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Adenoid cystic carcinoma of the breast; Carcinome adenoide kystique du sein  

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Adenoid cystic carcinoma of the breast is a rare neoplasm, accounting for only 0.1% of all malignant breast tumours. It is more common in women in the sixth decade of their lives and often in the sub areolar area. The clinical criteria is not specific and the radiographic examination showed a benign-appearing tumour. The preoperative diagnosis is possible with fine-needle aspiration cytology. The diagnosis is made by histological examination, presented a difficult differential diagnosis with cribriform carcinoma; so it is necessary to use histochemical or immunohistochemical techniques. The treatment is not well established. It consists of lumpectomy with radiation or mastectomy. Compared to other locations, adenoid cystic carcinoma of the breast has a favorable prognosis. Lymph node involvement or distant metastases seldom occur. The aim of our study is to describe the epidemiological, clinico pathological characteristics, the treatment and the prognosis of this rare type of breast tumour. (authors)

Kallel, R.; Bahri Zouari, I.; Gouiaa, N.; Charfi, S.; Ayadi, L.; Makni, S.; Sellami Boudawara, T. [CHU Habib-Bourguiba, Lab. d' Anatomie et de Cytologie Pathologiques, Sfax (Tunisia); Daoud, E. [CHU Habib Bourguiba, Service de Radiologie, Sfax (Tunisia); Daoud, J. [CHU Habib Bourguiba, Service de Radiotherapie, Sfax (Tunisia)

2009-07-15

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Literature review on the role of radiotherapy in the treatment of nasopharyngeal cystic adenoid carcinomas about two cases; Revue de la litterature sur la place de la radiotherapie dans le traitement des carcinomes adenoides kystiques du nasopharynx a propos de deux cas  

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The authors discuss the characteristics and the radiotherapy treatment procedures of cystic adenoid carcinomas, and more precisely the treatment of two of such cases of nasopharyngeal carcinomas. The first one had an incomplete resection surgery followed by curing radiotherapy: he has then been in local-regional control situation for 8 months. The second one had lung metastases, was treated chemotherapy and radiotherapy (decompressive treatment), and died six months after diagnosis. Radiotherapy is considered to be the treatment basis, whereas chemotherapy is a matter of controversy. Short communication

Hemmich, M.; Hassouni, K.; Elkacemi, H.; Errachdi, A.; Mouhajir, N.; Zaidi, H.; Benjaafar, N. [Institut national d' oncologie, Rabat (Morocco)

2011-10-15

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Adenoid removal  

Science.gov (United States)

... may also be recommended if your child has tonsillitis that keeps coming back. The adenoids normally shrink ... Wetmore RF. Tonsils and adenoids. In: Kliegman RM, Behrman RE, Jenson HB, Stanton BF, eds. Nelson Textbook of Pediatrics. 19th ed. Philadelphia, Pa: ...

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Enlarged Adenoids  

Science.gov (United States)

Often, tonsils and adenoids are surgically removed at the same time. Although you can see your tonsils by taking a mirror ... Parents MORE ON THIS TOPIC Tonsils and Tonsillectomies Tonsillitis What's It Like to Have Surgery? Strep Throat ...

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Tonsils and Adenoids  

Science.gov (United States)

Your tonsils and adenoids are part of your lymphatic system. Your tonsils are in the back of your throat. Your adenoids ... in through your mouth and nose. Sometimes your tonsils and adenoids become infected. Tonsillitis makes your tonsils sore and ...

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Pneumatose kystique iléale révélée par un volvulus du grêle  

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Full Text Available La pneumatose kystique intestinale est une pathologie rare qui se caractérise par la présence de kystes gazeux dans la paroi intestinale. Elle est asymptomatique ou pauci symptomatique, et le plus souvent découverte lors d’un examen d’imagerie ou d’endoscopie. Nous rapportons un cas de pneumatose iléale compliquée d’un volvulus sur bride chez un patient jamais opéré auparavant.

Khalid Aït Taleb

2010-08-01

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Enlarged Adenoids (For Parents)  

Science.gov (United States)

Enlarged Adenoids Often, tonsils and adenoids are surgically removed at the same time. Although you can see the tonsils at the back of the throat, ... Your Child for Anesthesia Apnea Tonsils and Tonsillectomies Tonsillitis All About Adenoids Having Your Tonsils Taken Out ...

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All about Adenoids  

Science.gov (United States)

... going into the hospital and having surgery. Sometimes, tonsils and adenoids are removed at the same time when a ... For Kids For Parents MORE ON THIS TOPIC Tonsillitis Having Your Tonsils Taken Out Snoring When Sinuses ...

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Adenoid ameloblastoma with dentinoid  

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Ameloblastomas seldom cause diagnostic difficulties due to classic histopathological presentations. Adenoid ameloblastoma is a rare variant in this category which can cause problem in diagnosis due to the presence of areas resembling adenomatoid odontogenic tumor (AOT) and occurrence of varying degrees of dentinoid formation. In this article, we report a case of adenoid ameloblastoma with dentinoid, which was diagnosed accurately after the third recurrence. To the best of our knowledge, so fa...

Saxena, Kartikay; Jose, Maji; Chatra, Lakshmi K.; Sequiera, Joyce

2012-01-01

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Correlation between morbid adenoid and atelectatic ear.  

Science.gov (United States)

We observed the nasopharynx of 30 patients with atelectatic ears (AE), and 10 with healthy ear drums and mouth breathing by CT scan, to examine the relation between adenoid and otitis media. The adenoids of those with healthy ear drums were of the large posterior type with free space in the pharyngeal fossa, while those with AE were of the large anterior type in 18 patients and of the pendulous projection type over the choana in the other 12. The anatomical location of the adenoids should be considered when one discusses the relation between the adenoid and otitis media. The "Toynbee phenomenon", in the pendulous projection type and in the large anterior type of adenoid, was considered to be one of the etiological factors in AE. To understand the etiology of otitis media, it seems important to investigate the reason why the anterior projection of the adenoids occurs. PMID:3478943

Kowata, I; Awataguchi, T

1987-01-01

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ADENOIDS IN ADULT SIBLINGS : IS IT FAMILIAL ?  

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Full Text Available Waldeyer’s ring is a collection of lymphoid tissue at the entrance to the aerodigestive tract.Adenoids are present in the nasopharyx.They begin to regress from the age of 8 to 10 years and nearly always disappear by adulthood.The persistent presence of adenoid tissue after puberty has been reported in literature.While investigating a case of nasal obstruction in adults,the possibility of persistence of adenoid tissue should be borne in mind.

Sulabha M Naik

2012-10-01

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Primary Esophageal Adenoid Cystic Carcinoma  

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Adenoid cystic carcinoma (ACC) is common in the salivary glands but rare in the esophagus. Routine esophagogastroscopy performed in a 54-year-old woman as part of a medical check-up revealed a submucosal tumor (1.5×1.0 cm) at the mid-esophagus. Endoscopic ultrasonography revealed a lesion with mixed echogenicity in the submucosal layer. The submucosal mass was removed by incisional endoscopic enucleation, and pathological analysis revealed epithelial cells with small hyperchromatic angular n...

Na, Youn Ju; Shim, Ki-nam; Kang, Min-jung; Jung, Ji Min; Ha, Chang Yun; Jung, Hae Sun; Baik, Su Jung; Kim, Seong-eun; Jung, Sung-ae; Yoo, Kwon; Moon, Il Hwan; Cho, Min Sun

2007-01-01

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Métastase cérébrale d'un carcinome du col utérin  

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Les métastases cérébrales des cancers du col de l?utérus sont extrêmement rares. Elles sont généralement supra-tentorielles, survenant à un stade avancé de la maladie et dans un cadre de néoplasie polymétastatique. La tumeur primitive est le plus souvent un carcinome épidermoïde peu différencié. Leur pronostic reste sombre malgré toutes les options thérapeutiques. Vu la rareté de cet événement et le peu de cas publiés dans la littérature, nous rapportons l'observation ...

2013-01-01

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[Multifocus or recurrent carcinoma adenoides cysticum].  

Science.gov (United States)

Authors present the case of carcinoma adenoides cysticum, which was located in small salivary glands of palatum. After surgical treatment and radiotherapy during 3 years observation of the patient two new ca adenoides cysticum focus were noticed. It can give evidence of cancer multifocus of cancer recurrents. PMID:9454210

Wójtowicz, P; Sujkowska, U; Kukwa, A; Sobczyk, G; Misztela, T

1995-01-01

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Adenoid cystic carcinoma of buccal mucosa.  

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Adenoid cystic carcinoma is a malignant neoplasm most commonly originating in salivary glands of head and neck region. Here we present a case report of a 50 year old male who was diagnosed with adenoid cystic carcinoma of the right buccal mucosa. The peculiarity of the lesion and the approach we made is the key factor in the presentation. PMID:22190804

Singh, Sanjay; Gokkulakrishnan; Jain, Jinendra; Pathak, Sachin; Singh, Kumar Tathagat

2010-09-01

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Adenoid Cystic Carcinoma of Buccal Mucosa  

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Adenoid cystic carcinoma is a malignant neoplasm most commonly originating in salivary glands of head and neck region. Here we present a case report of a 50 year old male who was diagnosed with adenoid cystic carcinoma of the right buccal mucosa. The peculiarity of the lesion and the approach we made is the key factor in the presentation.

Singh, Sanjay; Gokkulakrishnan; Jain, Jinendra; Pathak, Sachin; Singh, Kumar Tathagat

2010-01-01

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Carcinome neuroendocrine du sein: à propos d'un cas et revue de la littérature  

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Le carcinome neuroendocrine primitif du sein est une tumeur rare qui a été reconnue par la dernière édition de la classification OMS du cancer du sein publiée en 2003. Le diagnostic est évoqué sur des critères morphologiques et confirmé par l'expression des marqueurs neuroendocrines (chromogranine et synaptophysine) par plus de 50% des cellules tumorales. Nous rapportons un nouveau cas de carcinome neuroendocrine primitif du sein, et à travers une revue de la littérature, nous dét...

El Fatemi, Hinde; Hammas, Nawal; Moumna, Kaoutar; Bedahou, Mouhcine; Mellas, Nawfel; Mesbahi, Omar

2012-01-01

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Carcinome épidermoïde du sein: à propos de 3cas et revue de la littérature  

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Les carcinomes épidermoides du sein sont rares. Ils sont d'origine métaplasiques. Leur histogénèse est controversée. La présentation clinique et mammographique n'est pas spécifique, l'aspect kystisé des lésions et la présence de nécrose sont recherchés à l’échographie mammaire. Le diagnostic est histologique. Ce cancer est réputé être peu lymphophile et non hormonodépendant. Le traitement rejoint celui des carcinomes infiltrants canalaires et repose sur la chirurgie, la ra...

Alaoui, Fatima Zohra Fdili; Benkirane, Saad; Chaara, Hekmat; Bouguern, Hakima; Melhouf, Moulay Abdilah

2012-01-01

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Pulmonary adenoid cystic carcinoma : An unusual presentation  

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Full Text Available Adenoid cystic carcinoma is a rare but distinctive salivary gland type malignant neoplasm that arises infrequently in the respiratory tract, where it is largely seen in the trachea or large airways. A 29-year-old female who presented with a peripheral lung mass due to pulmonary adenoid cystic carcinoma is reported in view of its unusual location, early age of presentation and lack of such reports in the recent literature. Lung India 2007; 24 : 28-29

Dixit Ramakant

2007-01-01

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Subglottic adenoid cystic carcinoma mistaken for asthma  

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Adenoid cystic carcinoma rarely occurs within the subglottic larynx. In this study, a case of subglottic adenoid cystic carcinoma was reported. A 54 year-old Chinese woman developed a sudden onset of chest distress and cough worsening after physical exertion, and was diagnosed with, and treated as, bronchial asthma. Regular anti-asthmatic therapy did not improve the symptoms. Until a sudden dyspnea, a cervicothoracic computerized tomography (CT) revealed that her upper airway was obstructed b...

Wang, Hua-lin; Xu, Lin; Li, Fu-jun

2009-01-01

 
 
 
 
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Pneumatose kystique intestinale r?v?l?e par une st?nose d'une anastomose gastro-j?junale: ? propos d'un cas  

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La pneumatose kystique intestinale est la présence de bulles gazeuses dans la paroi et les séreuses du tube digestif. Il s'agit d'une pathologie bénigne, rare, de diagnostic radiologique et de traitement médical. Nous rapportons le cas d'un homme âgé de 42ans, opéré il y a 6ans pour une sténose du bulbe duodénal d'origine ulcéreuse, il avait bénéficié d'une gastro-entéro-anastomose avec bivagotomie tronculaire. Il a été hospitalisé pour des vomissements associés à des épigastralgies. le patient a bénéficié d'une fibroscopie oeso-gastro-duodénale qui a trouvé une stase gastrique gênant toute exploration, ce qui a conduit à la réalisation d'une tomodensitométrie abdominale qui a objectivé un énorme estomac de stase en amont d'une sténose de l'anastomose gastro jéjunale, une pneumatose kystique intestinale et un pneumopéritoine. Le patient a été opéré et l'exploration a trouvé une ascite, un volumineux estomac de stase et des adhérences entre le grêle et le colon droit, sièges de la pneumatose, provoquant un tour de spire (volvulus) de l'ancienne anastomose gastro-jéjunale. L'estomac était atone. Une gastrectomie des 2/3 emportant l'ancienne anastomose suivie d'une anastomose type Finsterer manuelle a été réalisée. Les suites post opératoires étaient simples. La pneumatose kystique intestinale est une affection bénigne, de diagnostic radiologique. Le scanner permet d’étudier la diffusion des gaz dans les séreuses digestives. Son traitement est habituellement médical alors que ses complications peuvent relever d'un traitement chirurgical comme pour notre patient.

El Matiallah, Mohammed Amine; El Bouhaddouti, Hicham; Mouaqit, Ouadii; Benjelloun, El Bachir; Ousadden, Abdelmalek; Taleb, Khalid Ait

2013-01-01

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Perineural spread in adenoid cystic carcinoma  

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This is a report of adenoid cystic carcinoma occurred in the palate in 30-year-old patient with a complaint of exophytic mass.The authors diagnosed it as adenoid cystic carcinoma by the clinical examination, radiographic findings and histopathological findings. The obtained results are as follows: 1. In the clinical examination, asymptomatic exophytic mass of palate was observed. 2. In radiographic findings, soft tissue mass infiltrated the left maxillary sinus, nasal cavity, infraorbital fossa, hard palate, pterygopalatine fossa and pterygoid plate, and enhanced soft tissue mass was also observed in CT. 3. In histopathological findings, tubular and solid patterns of glandular structures were observed and the infiltration of tumor cells into the nerve fibers was also observed. 4. Two years after radical surgery, radiation therapy and chemotherapy, the perineural spread to orbital area was observed. 5. Much longer follow-up than 5 years is needed for early diagnosis of recurrence and distant metastasis.

Lim, Sug Young; Choi, Eun Suk; Kim, Mi Sook; Koh, Kwang Joon [Dept. of Oral Radiology, College of Dentistry, Chonbuk National University, Chonju (Korea, Republic of)

1992-08-15

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Perineural spread in adenoid cystic carcinoma  

International Nuclear Information System (INIS)

This is a report of adenoid cystic carcinoma occurred in the palate in 30-year-old patient with a complaint of exophytic mass.The authors diagnosed it as adenoid cystic carcinoma by the clinical examination, radiographic findings and histopathological findings. The obtained results are as follows: 1. In the clinical examination, asymptomatic exophytic mass of palate was observed. 2. In radiographic findings, soft tissue mass infiltrated the left maxillary sinus, nasal cavity, infraorbital fossa, hard palate, pterygopalatine fossa and pterygoid plate, and enhanced soft tissue mass was also observed in CT. 3. In histopathological findings, tubular and solid patterns of glandular structures were observed and the infiltration of tumor cells into the nerve fibers was also observed. 4. Two years after radical surgery, radiation therapy and chemotherapy, the perineural spread to orbital area was observed. 5. Much longer follow-up than 5 years is needed for early diagnosis of recurrence and distant metastasis.

1992-08-01

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Adenoid cystic carcinoma of uterine cervix.  

Science.gov (United States)

A 68-year-old postmenopausal patient with adenoid cystic carcinoma of the cervic is described. Thirty-two other cases were collected from the literature, and a clinicopathologic analysis for the whole group is presented. The study indicates that a) adenoid cystic carcinoma usually occurs in postmenopausal patients in the commonest presenting problems; c) vaginal cytology was abnormal in most cases in which it was reported; d) the lesion usually forms a mass and infiltrates parametrial and paracervical tissues; e) the tumor is frequently associated with squamous cell carcinoma (in situ or invasive) or other types of cancer; f) local recurrence after radical surgery and /or irradiation, as well as pelvic and widespread metastases, can occur; and g) the histogenesis of this type of tumor is unclear. The various possibilities are discussed. PMID:1143730

Ramzy, I; Yuzpe, A A; Hendelman, J

1975-06-01

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Paediatric refractory rhinosinusitis secondary to hypertrophied adenoids: management and review of literature.  

Directory of Open Access Journals (Sweden)

Full Text Available Background /Objectives: Hypertrophied adenoids are the most common cause of refractory sinusitis in paediatric age. We study 42 cases of patients of chronic adenoiditis with adenoid facies and refractory chronic rhinosinusitis managed by endoscopic assisted adenoidectomy (EAA and conventional adenoidectomy (CA. Materials and method: 42 cases of chronic refractory sinusitis with adenoid facies secondary to hypertrophied adenoids were randomized into 2 groups during the study period of 12 months from August 2012 to July 2013. Group A (n=21 underwent endoscope assisted adenoidectomy and Group B(n=21 underwent conventional adenoidectomy. Result: Endoscopic assisted adenoidectomy proves to be more effective in managing adenoid facies and chronic refractory rhinosinusitis with adenoid hyperplasia. Conclusion: Visualization of the adenoid mass using endoscope helps complete removal of the diseased adenoids. Endoscopic assisted adenoidectomy is treatment of choice in adenoid facies and chronic refractory rhinosinusitis with adenoid hyperplasia and more effective than conventional adenoidectomy.

Gautham MK

2014-06-01

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Adenoid Cystic Carcinoma of the Skull Base  

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Adenoid cystic carcinoma (ACC) is a slowly growing tumor with a particular tendency to infiltrate the surrounding tissue by perineural spread. The clinical diagnosis may prove difficult due to the submucons extension of the tumor, especially at the skull base. This article outlines the clinical characteristics, diagnostics, and treatment modalities in a series of 56 patients with an ACC in the head and neck diagnosed between 1970 and 1998 in 32 females and 24 males. The youngest patient was a...

Issing, Peter R.; Hemmanouil, Ilias; Sto?ver, Timo; Kempf, Hans-georg; Wilkens, L.; Heermann, R.; Lenarz, Thomas

1999-01-01

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Adenoid Cystic Carcinoma of the Larynx  

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Full Text Available This is case where a middle aged gentleman presented with history of progressively worseninghoarseness for 1 year. On further history taking and examination including imaging noted patient had supraglottic mass arising from left ventricle, measuring 2x2cm with smooth surface mimicking a benign lesion. Histopatological examination revealed as adenoid cystic carcinoma of left ventricle with perineural invasion . [Cukurova Med J 2014; 39(3.000: 611-615

Roopesh Sankaran

2014-06-01

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Whole exome sequencing of adenoid cystic carcinoma  

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Adenoid cystic carcinoma (ACC) is a rare malignancy that can occur in multiple organ sites and is primarily found in the salivary gland. While the identification of recurrent fusions of the MYB-NFIB genes have begun to shed light on the molecular underpinnings, little else is known about the molecular genetics of this frequently fatal cancer. We have undertaken exome sequencing in a series of 24 ACC to further delineate the genetics of the disease. We identified multiple mutated genes that, c...

Stephens, Philip J.; Davies, Helen R.; Mitani, Yoshitsugu; Loo, Peter; Shlien, Adam; Tarpey, Patrick S.; Papaemmanuil, Elli; Cheverton, Angela; Bignell, Graham R.; Butler, Adam R.; Gamble, John; Gamble, Stephen; Hardy, Claire; Hinton, Jonathan; Jia, Mingming

2013-01-01

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Radiation therapy in adenoid-cystic carcinoma  

International Nuclear Information System (INIS)

Between 1949-1977, 74 patients with adenoid-cystic carcinoma of various head and neck sites were treated by radiation therapy at Memorial Sloan-Kettering Cancer Center. Radiation therapy alone was employed in 49 patients for recurrent, unresectable disease, and in 25 patients it was given as an adjunct to surgical resection. Among the 49 patients treated with radiation therapy alone, tumor regression was seen in 47 (96%). However, 44 of the 47 (93.5%) subsequently relapsed locally. Relapse occurred within 18 months in one-half of the patients and within 5 years in all of them. Of the 25 patients who received adjunctive radiation therapy about one-half relapsed locally within five years. There were 9 patients in this group, however, whose field size exceeded 8x8 cm and the dose of radiation also exceeded 4500 rad: 88% of these patients remained relapse-free at 5 years, compared with only 22% of the other 16 whose dose, or field size, or both, were inadequate by comparison. These data suggest that when irradiation is employed for advanced, inoperable adenoid-cystic carcinoma, it offers useful palliation but is rarely, if ever, curative. Postoperative irradiation, on the other hand, might improve the local control and the survival in patients with operable adenoid-cystic carcinoma who are at high risk for relapse, but only if the field size and the dose are adequate

1984-01-01

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Adenoid cystic carcinoma of the head and neck  

International Nuclear Information System (INIS)

The adenoid cystic carcinoma or cylindroma develop principally from salivary glands. It is the most frequently at the level of head and neck. The aim of this work is to analyse the therapy data and to determine the prognostic factors of adenoid cystic carcinomas through a retrospective study. (N.C.)

2007-11-01

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Plain radiographic evaluation of children with obstructive adenoids  

International Nuclear Information System (INIS)

Background: There are several methods of evaluating adenoidal size pre-operatively. Plain nasopharyngeal radiography is a common investigative modality: it has been advocated, and also condemned. Aim: This study was intended to assess nasopharyngeal airway obstruction by the adenoids using plain X-rays; and also to find correlation if any, with the symptomatology. Methods: This is a retrospective study carried out between January and December 2008. The case notes and plain X-rays of the nasopharynx of 34 paediatric patients with clinical features of obstructive adenoids were analyzed. Results: A total of 34 children were studied, 22 (64.7%) were males and 12 (35.3%) were females. Their ages ranged between 7 months and 10 years: mean age was 3.55 years, standard deviation 2.723. Majority (67.6%) of the children were in the age group 0-4 years. The lowest symptomatology assessment score was 0 and the highest was 3. Children 4 years and below had the highest symptomatology scores. The minimum adenoidal-nasopharyngeal ratio was 0.35 and the maximum was 0.94. There was no significant difference in the mean adenoidal-nasopharyngeal ratio of males and females (t = 0.407; p = 0.692). Many (75.0%) of the children with moderate to severe nasopharyngeal airway obstruction by the adenoids were in the age bracket 0-4 years. The lowest adenoidal-nasopharyngeal ratio score was 0 and the highest was 3. Children 4 years and below had the highest adenoidal-nasopharyngeal ratio scores. There was a very weak nonsignificant correlation between the symptomatology assessment score and the radiological assessment score (r = 0.168; p = 0.375). Conclusion: The adenoidal-nasopharyngeal ratio is reliable in assessing the nasopharyngeal airway in children with obstructive adenoids.

2011-08-01

32

Pulmonar collision tumor: metastatic adenoid cystic carcinoma and lung adenocarcinoma.  

Science.gov (United States)

We report an extraordinary case of collision tumor consisting of a lung adenocarcinoma and a metastatic adenoid cystic carcinoma in a 56 year-old man. He was diagnosed with a pulmonary nodule 11 years after treatment of an adenoid cystic carcinoma of the right maxillary sinus. A non-small cell carcinoma was observed when a transbronchial biopsy was performed. The other component of the nodule was only diagnosed with pathological examination of the resection specimen. PMID:21802893

Blanco, M; García-Fontán, E; Ríos, J; Rivo, J E; Fernández-Martín, R; Cañizares, M A

2012-01-01

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Sweat gland differentiation in mammary adenoid cystic carcinoma.  

Science.gov (United States)

A breast tumor is described which presented as an exophytic mass, and which by both light and electron microscopic examination had a biphasic histologic composition. In the superficial area adjacent to the epidermis, it showed tubular differentiation similar to a cutaneous tubular apocrine adenoma and salivary basal cell adenoma, and, in the deeper portion, it had the characteristic features of adenoid cystic carcinoma. Their possible interrelationships are discussed, and mammary adenoid cystic carcinoma is briefly reviewed. PMID:221096

Prioleau, P G; Santa Cruz, D J; Buettner, J B; Bauer, W C

1979-05-01

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Characterisation of adenoid cystic carcinoma of the breast by immunohistology.  

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An adenoid cystic carcinoma of the breast in a 78 year old woman was analysed immunohistologically for the production of type IV collagen, the expression of vimentin, epithelial membrane antigen (EMA) and steroid receptors, and the proliferative activity of the tumour cells. The data were compared with those obtained in eight adenoid cystic carcinomas of salivary glands and in ductal carcinomas of the breast with a cribriform growth pattern. The patients' ages were as follows: 45-80 years (me...

Du?e, W.; Herbst, W. D.; Loy, V.; Stein, H.

1989-01-01

35

Carcinome épidermoïde de la vulve sur une grossesse gémellaire: à propos d’un cas aux cliniques universitaires de Lubumbashi  

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Nous rapportons un cas de carcinome épidermoïde de la vulve chez gestante porteuse d’une grosse gémellaire qui a consulté dans le service de gynéco-obstetrique des Cliniques Universitaires de Lubumbashi à un stade avancé de la pathologie et après avoir essayé un traitement insuffisant ailleurs.

Idi, Yves Isango; Muteya, Michel Manika; Ngama, Christian Kakisingi; Mwazaz, Roger Munan; Makinko, Paul Ilunga; Kaj, Fanny Malonga; Tambwe, Albert Mwembo; Mukalenge, Faustin Chenge

2013-01-01

36

Adenoid cystic carcinoma of the cervix.  

Directory of Open Access Journals (Sweden)

Full Text Available Adenoid cystic carcinoma constitute around 0.4 to 1.7% of all carcinomas of cervix. It generally presents in elderly age group, however few cases in younger age have also been reported. Majority of cases present in early stage. Though concluding statement regarding the results cannot be made from the cases accumulated from the various reported series, nonetheless this review shows that radiotherapy too is effective in early stage and even in stage I results with radiotherapy appear better than surgery. In advanced stage outcome is invariably poor. In early stage main pattern of failure is distant metastasis. Both local and distant failure are observed in stage III and IV. Though lung is the commonest site of metastases (51%, abdominal cavity and brain are also found to be involved in some cases. Limited experience shows effectiveness of high doses of cisplatin and multiagent chemotherapy. Cases of early stage disease having risk for metastases and local failure should be identified and managed with multimodality treatment using surgery for bulky disease with post-operative radiotherapy and chemotherapy. In advanced stages combination of chemotherapy and radiotherapy is required. Exenterative surgery for central failure has been used effectively. Overall no evidence of disease rate is found to be about 48%, with mean follow-up of 39 months.

Dixit S

1993-10-01

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Adenoid cystic carcinoma of the peripheral lung: a case report  

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Full Text Available Abstract Adenoid cystic carcinoma of the peripheral lung is a rare entity. We recently encountered a patient with adenoid cystic carcinoma. A 75-year-old woman showed a nodular lesion with 10 mm in diameter in the right upper lung field on chest radiography. The diagnosis was unclear, but lung cancer could not be ruled out. Thoracoscopic biopsy was performed, and intraoperative pathological diagnosis revealed the carcinoma of the lung. We enforced upper lobectomy and mediastinal lymph node dissection to the patient. Histopathological examination revealed adenoid cystic carcinoma with a characteristic cribriform structure. Immunohistochemical examination revealed that the tumor cells were positive for thyroid transcription factor 1 (TTF-1, this tumor was diagnosed primary ACC of the lung.

Kitada Masahiro

2010-08-01

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Radiographic adenoid evaluation - suggestion of referral parameters / Avaliação radiográfica da adenoide - sugestão de parâmetros de referência  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in portuguese OBJETIVO: o objetivo deste estudo foi de investigar a utilidade de medidas radiográficas destinadas à avaliação da tonsila faríngea a serem utilizadas como potenciais parâmetros de encaminhamento. MÉTODOS: crianças de quatro a 14 anos, de ambos os gêneros, que apresentavam queixas referentes à [...] obstrução nasal foram submetidas à radiografia do cavum. Os registros radiográficos (n = 120) foram avaliados de acordo com parâmetros categóricos e quantitativos, e dados resultantes foram comparados ao exame padrão-ouro de videonasofaringoscopia, em relação às suas taxas de acurácia (sensibilidade, valor preditivo negativo, especificidade e valor preditivo positivo). RESULTADOS: os parâmetros radiográficos categóricos apresentaram baixa sensibilidade para a identificação de pacientes portadores de 2/3 de obstrução do espaço coanal. No entanto, alguns destes parâmetros apresentaram especificidades relativamente altas quando 3/4 de obstrução coanal era o ponto de corte de interesse. Dentre as variáveis quantitativas, um modelo matemático se mostrou mais adequado para identificar pacientes com mais de 2/3 de obstrução coanal. CONCLUSÃO: este modelo demonstrou, assim, ser potencialmente útil como método de rastreamento para identificação de pacientes com pelo menos 2/3 de obstrução adenoidiana. Além disso, um dos parâmetros categóricos analisados demonstrou ser relativamente mais útil e potencialmente seguro para eliminar pacientes queixosos com menos de 3/4 de obstrução a serem indicados à adenoidectomia. Abstract in english OBJECTIVE: this study aimed to evaluate the usefulness of current radiographic measurements, which were originally conceived to evaluate adenoid hypertrophy, as potential referral parameters. METHODS: children aged from 4 to 14 years, of both genders, who presented nasal obstruction complaints [...] , were subjected to cavum radiography. Radiographic examinations (n = 120) were evaluated according to categorical and quantitative parameters, and data were compared to gold-standard videonasopharyngoscopic examination, regarding accuracy (sensitivity, negative predictive value, specificity, and positive predictive value). RESULTS: radiographic grading systems presented low sensitivity for the identification of patients with two-thirds choanal space obstruction. However, some of these parameters presented relatively high specificity rates when three-quarters adenoid obstruction was the threshold of interest. Amongst the quantitative variables, a mathematical model was found to be more suitable for identifying patients with more than two-thirds obstruction. CONCLUSION: this model was shown to be potentially useful as a screening tool to include patients with, at least, two-thirds adenoid obstruction. Moreover, one of the categorical parameters was demonstrated to be relatively more useful, as well as a potentially safer assessment tool to exclude patients with less than three-quarters obstruction, to be indicated for adenoidectomy.

Murilo F.N., Feres; Juliana S., Hermann; Ana C., Sallum; Shirley S.N., Pignatari.

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Clinical analysis on nasopharyngeal adenoid cystic carcinoma  

International Nuclear Information System (INIS)

Objective: To investigate the clinical features, treatment outcome and prognosis of patients with nasopharyngeal adenoid cystic carcinoma(ACC). Methods: From March 1963 to August 2002, 33 patients with ACC were retrospectively reviewed. Among them, 13 received multimodality therapy (S + R in 9 and R + S in 4) and the remaining 20 received radiotherapy alone. The interval between the first visit and clinical diagnosis was 12 months (1.0-36.4 months). The misdiagnosis rate was 55% (18/33 ), with the most common error of otitis media. The clinical symptoms of ACC were similar to those of squamous carcinoma in nasopharynx, though the cervical lymph node metastasis was rare (12%) and cranial nerve invasion was common (58%). Results: After a median follow-up of 60.8 months (5.0-245.2 months), the 5- and 10-year overall survival rates, free-disease survival rates, local regional control rates and metastasis-free survival rates were 66% and 29%, 41% and 27%, 61% and 40%, 62% and 62%, respectively. Among the 20 patients (61%) with recurrence, 15 had local regional failure (13 in situ and 2 in cervical lymph node), and 9 had distant metastasis (5 in the lung, 2 in the lung and bone, 1 in the liver and 1 in the bone). Univariate analysis showed that clinical stage was a prognostic factor (I + II vs III + IV, P=0.009), while treatment modality(radiotherapy alone vs multimodality therapy) was not. Conclusions: Nasopharyngeal ACC is a locally aggressive disease with a long course. Either radiotherapy alone or multimodality therapy( S + R/R + S) is effective in the treatment. (authors)

2009-01-01

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Diagnosis and Treatment of Tracheal or Bronchuotracheal Adenoid Cystic Carcinoma  

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Full Text Available Background and objective Adenoid cystic carcinoma is primary bronchopulmonary carcinoma with low malignancy, and 43 patients treated in the past 50 years in our hospital were retrospectively studied. The aim of this study is to discuss the clinical symptoms, pathologic characteristic and therapeutic method of primary tracheal or bronchuotracheal adenoid cystic carcinoma. Methods This study summarized total 43 patients of primary tracheal or bronchus adenoid cystic carcinoma treated in our hospital from Jan. 1958 to Dec. 2007. Among them, 40 patients were treated by surgical resection, and 3 patients were treated by fiberoptic bronchoscope’s interventional treatment. Results The 1-yr, 3-yr, 5-yr survival rates of the 43 patients above were 100% (41/41, 89.5% (34/38, 87.1% (27/31, respectively. Conclusion Primary tracheal or bronchus adenoid cystic carcinoma are rare and low malignancy carcinoma. The clinical symptoms of them are not typical. The best treatment is early detection and taking measures of operation plus radiotherapy. The other palliative treatment is fiberoptic bronchoscope’s interventional treatment.

Ming QIN

2010-06-01

 
 
 
 
41

Adenoid cystic carcinoma in head and neck  

International Nuclear Information System (INIS)

Objective: To analyze adenoid cystic carcinoma (ACC) in head and neck region with respect to age, sex, site of origin, histological type, role of Fine Needle Aspiration Cytology (FNAC) in diagnosis, metastasis, various treatment modalities and their effectiveness in local control of disease. Design: A descriptive study. Place and Duration of Study: Department of Otolaryngology and Head and Neck Surgery, Pakistan Institute of Medical Sciences, Islamabad from January, 1988 to December 1998. Patients and Methods: Case histories of 26 patients with histologically proven ACC in the head and neck region were selected from the departmental record. Clinical data included age and sex of patient, tumor location, presenting symptoms FNAC reports, predominant histological pattern of tumor, tumor stage, treatment modality, tumor recurrences and metastasis and final clinical status. Results: Among 26 cases, there were 16 males and 10 females. The mean age was 52 years (Range 30-75 years). In 57.7% patients, tumor was located in minor salivary glands whereas in 42.3% , major salivary glands were the site of origin. Plate was the commonest site of origin. FNAC reports showed ACC in 76.9% patients. In 80.8% patients, histopathological reports clearly mentioned the predominant histological type of ACC. Histological pattern was 66.6% cribriform, 23.8% tubular and 9.5% were of solid pattern, Regional lymph node metastasis was found in only 7.6%. Distant metastasis developed in 11.5%, whereas 69.2% patients were treated by surgery followed by postoperative radiotherapy, only 11.1% develop recurrence at the primary site. Radiotherapy was given to only one patient (3.8%), who was alive with disease at the time of last follow up. Conclusion: The peak age incidence of ACC in head and neck region was in 5th decade with slight male preponderance. Tumor was more common in minor salivary glands and palate was the commonest site of origin. FNAC was helpful in diagnosis of ACC in majority of cases. Cribriform subtype was the commonest histological pattern. ACC had very low regional lymph node metastasis. Lung was the commonest site of distant metastasis. surgical excision followed by radiotherapy was the best treatment modality for achieving local control on disease. (author)

2002-09-01

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Carcinoma adenoide quístico primario de bronquio lobar: Caso clínico / Primary adenoid cystic carcinoma of the lobar bronehus: Case report  

Scientific Electronic Library Online (English)

Full Text Available SciELO Chile | Language: Spanish Abstract in spanish El carcinoma adenoide quístico primario de la vía aérea es una neoplasia muy rara. Reportamos el caso de un paciente de 60 años de edad quien consultó por hemoptisis y disnea de esfuerzo. Una tomografía computarizada del tórax reveló una masa en el bronquio fuente y lobar superior del pulmón derecho [...] . Se realizó una lobectomía superior derecha en manguito. El estudio histopatológico mostró un carcinoma adenoide quístico. Se administró radioterapia adyuvante. La cirugía y la radioterapia son las bases del manejo de este tipo de tumores. Abstract in english Primary airway adenoid cystic carcinoma is very uncommon. We report a 60 years old male consulting for hemoptysis and dyspnea. A chest CAT scan showed a mass in the right superior lobar bronehus. The patient was subjected to a right superior sleeve lobectomy and the pathological study of the surgica [...] l piece revealed an adenoid cystic carcinoma. The patient received adjuvant radiotherapy. Surgery and radiation therapy are the mainstay of treatment for this type of tumors.

LEONIDAS, TAPIAS-VARGAS; LUIS FELIPE, TAPIAS-VARGAS; LEONIDAS, TAPIAS; MARÍA EMMA, GARCÍA; JULIO CÉSAR, MANTILLA; ERNESTO, GARCÍA.

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Primary Pulmonary Adenoid Cystic Carcinoma Located at the end of the Terminal Bronchiolus: Case Repo  

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Full Text Available Pulmonary adenoid cystic carcinoma is a rare salivary glandtype malignant neoplasm of respiratory tract that is usually located in the central airways such as trachea and main bronchus. Adenoid cystic carcinoma arising from the peripheral lung is quite rare. Here, we report adenoid cystic carcinoma that developed at the end of the terminal bronchiol of the right lung lower lobe of a 52-year-old woman.

Tülin Durgun Yetim

2012-07-01

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Adenoid Cystic Carcinoma of the Buccal Mucosa: A Case Report with Review of Literature  

Science.gov (United States)

Minor salivary gland neoplasms of the buccal mucosa are relatively uncommon. Adenoid cystic carcinoma (ACC), a well-defined entity, occurs most of the times in the parotid, submandibular glands and palate, as far as the intraoral site is concerned. Adenoid cystic carcinoma tends to have an indolent, extended clinical course with wide local infiltration and late distant metastases. We are presenting a case of an adenoid cystic carcinoma of the buccal mucosa in a 48-year-old female patient.

S, Vidyalakshmi; R, Aravindhan

2014-01-01

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Correlación microbiológica en cultivo de adenoides y glue en pacientes con OME / Microbiological correlation between adenoid and glue ear cultures in patients with OME  

Scientific Electronic Library Online (English)

Full Text Available SciELO Chile | Language: Spanish Abstract in spanish Introducción: La otitis media con efusión (OME) sigue siendo la patología otológica más prevalente en los preescolares de Chile; su etiología y factores predisponentes aún no están del todo claro; por ende su tratamiento es controversial. Objetivo: Demostrar una correlación microbiológica en cultivo [...] s de tejido adenoídeo y glue de ambos oídos en pacientes con OME. Material y método: Estudio prospectivo caso/control, donde se analizaron los cultivos bacterianos de tejido adenoideo y glue de ambos oídos en 40 pacientes con OME y cultivos bacterianos de tejido adenoídeo de 40 pacientes con hiperplasia adenoídea sin OME. Resultados: Casos: Cinco cultivos negativos de adenoides (12,5%), 28 positivos a comensales (70%) y 7 positivos a gérmenes no habituales (17,5%). El glue presentó cultivo negativo en 72,5% OD y 77,5% OI. Los cultivos de adenoides en los controles no difieren mayormente a los casos. Discusión: No se pudo establecer una correlación microbiológica entre glue y adenoides en pacientes con OME. Conclusiones: El número de cultivos de glue negativos se correlaciona con la literatura mundial. No existe un patrón que permita correlacionar los cultivos de adenoides de los casos con los cultivos de glue, ni con los cultivos de adenoides de los controles. Abstract in english Introduction: Otitis Media with Effusion is still the most prevalent otological pathology in preschool children in Chile. Its etiology and predisposing factors are not entirely clear yet. Hence, its treatment is controversial. Aim: To demonstrate a microbiological correlation in adenoid tissue and g [...] lue ear cultures in both ears in patients with OME. Material and method: Prospective case control study, which analyzed bacterial adenoid tissue cultures and glue ear cultures in both ears in 40 patients with OME, and a second control group of bacterial cultures in 40 patients with adenoid hyperplasia without ear effusion. Results: Cases: Five negatives in adenoid cultures (12.5%), 28 positive to guest bacteria (70%) and 7 positive at unusual germs (17.5%). The glue ear presented negative culture at 72.5% in the right ear and 77.5% in the left ear. Adenoid control cultures did not differ with OME studied cases. Discussion: A microbiological glue ear and adenoid correlation could not be established. Conclusions: The number of negative glue ear cultures is similar to published literature. There is not a pattern which allows a positive correlation between adenoid cases cultures and glue ear cultures or with control adenoid cultures.

Pinto C, Rodrigo; Carmine A, Eduardo; Rahal E, Maritza.

46

Primary tuberculosis of the adenoids in an 11-year-old male presenting with hearing loss: a case report.  

Science.gov (United States)

Hypertrophy of adenoids is usually caused by repeated throat infections, especially viral and bacterial infections, that in microscopic examination reveal reactive lymphoid follicular hyperplasia. Herein, we present an 11-year-old boy who developed hearing loss in his left ear three months before admission, and in direct examination the adenoids were hypertrophied. Histopathological study of the resected adenoid revealed caseating granulomatous inflammation. Based on histopathological and clinical findings, primary tuberculosis of adenoids was suggested which was confirmed by PCR. PMID:23946986

Taghipour-Zahir, S; Baradaranfar, M H; Zolfaghari, A A

2013-04-01

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Bortezomib Followed by the Addition of Doxorubicin at Disease Progression in Treating Patients With Locally Advanced, Recurrent, or Metastatic Adenoid Cystic Carcinoma (Cancer) of the Head and Neck  

Science.gov (United States)

Recurrent Adenoid Cystic Carcinoma of the Oral Cavity; Recurrent Salivary Gland Cancer; Salivary Gland Adenoid Cystic Carcinoma; Stage III Adenoid Cystic Carcinoma of the Oral Cavity; Stage III Salivary Gland Cancer; Stage IV Adenoid Cystic Carcinoma of the Oral Cavity; Stage IV Salivary Gland Cancer

2013-01-23

48

Carcinome ?pidermo?de de la vulve sur une grossesse g?mellaire: ? propos d'un cas aux cliniques universitaires de Lubumbashi  

Science.gov (United States)

Nous rapportons un cas de carcinome épidermoïde de la vulve chez gestante porteuse d’une grosse gémellaire qui a consulté dans le service de gynéco-obstetrique des Cliniques Universitaires de Lubumbashi à un stade avancé de la pathologie et après avoir essayé un traitement insuffisant ailleurs.

Idi, Yves Isango; Muteya, Michel Manika; Ngama, Christian Kakisingi; Mwazaz, Roger Munan; Makinko, Paul Ilunga; Kaj, Fanny Malonga; Tambwe, Albert Mwembo; Mukalenge, Faustin Chenge

2013-01-01

49

Serum immunoglobulin E levels in relation to adenoid surgery.  

Science.gov (United States)

The adenoid tissue is an immunecompetent lymphoid organ, which has the capacity of reacting against numerous antigens. We have studied the influence that the elimination of the said tissue would have on the total IgE serum levels in 33 patients of an average age of 5 and criteria of adenoidectomy and in whom these levels were measured before and after surgery. We have not noticed any statistically significant differences in the IgE values after adenoidectomy with respect to those prior to surgery, which were normal. Adenoidectomy, like other authors have observed after tonsillectomy, does not alter the IgE serum values. PMID:9645261

Prados, M; Sánchez, F; Olivencia, M; Paulino, A; Aragón, R

1998-01-01

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Pulmonary adenoid cystic carcinoma with calcification manifesting high CT-number mass report of a case  

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The presence of calcification in a pulmonary nodule is usually a sign of benignity. However, infrequently calcification can occur in a malignant lesion. Adenoid cystic carcinoma of the lung is a type of bronchial adenoma, and a rare disease. We recently experienced a case of adenoid cystic carcinoma with diffuse and homogenous calcification involving the right middle lobe associated with regional lymph node metastasis. CT examination revealed the mass to have high Hounsfield unit of 193, which is unusual for a malignant tumor which usually has a Hounsfield unit lower than 165. From this case, it is learned that adenoid cystic carcinoma has high Hounsfield unit when it is calcified.

Ro, Hee Jeong; Choi, Ihl Bohng; Park, Seog Hee; Kim, Choon Yul; Eahk, Yong Whee; Kang, Chang Suck [Catholic University Medical College, Seoul (Korea, Republic of)

1987-06-15

51

Pulmonary adenoid cystic carcinoma with calcification manifesting high CT-number mass report of a case  

International Nuclear Information System (INIS)

The presence of calcification in a pulmonary nodule is usually a sign of benignity. However, infrequently calcification can occur in a malignant lesion. Adenoid cystic carcinoma of the lung is a type of bronchial adenoma, and a rare disease. We recently experienced a case of adenoid cystic carcinoma with diffuse and homogenous calcification involving the right middle lobe associated with regional lymph node metastasis. CT examination revealed the mass to have high Hounsfield unit of 193, which is unusual for a malignant tumor which usually has a Hounsfield unit lower than 165. From this case, it is learned that adenoid cystic carcinoma has high Hounsfield unit when it is calcified

1987-06-01

52

Differentiation of Nevoid Basal Cell Carcinoma from Epithelioma Adenoides Systicum; a Clinicopathologic and Histochemical Study.  

Science.gov (United States)

The lesions from patients with nevoid basal cell carcinoma are histologically and histochemically indistinguishable from the various patterns and types of basal cell carcinoma. Overlapping features are present in lesions of epithelioma adenoides cysticum ...

J. H. Graham J. K. Mason H. R. Gray E. B. Helwig

1964-01-01

53

Cell-type dependent biomarkers expression in adenoid cystic carcinoma (ACC): biological and therapeutic implications  

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Adenoid cystic carcinoma (ACC), a rare and progressive salivary malignancy, is characterized by cellular, morphologic and clinical heterogeneity. We hypothesize that its dual cellular composition plays an important role in biomarker evaluation, tumor biological behavior and therapy response.

Bell, Diana; Roberts, Dianna; Kies, Merrill; Rao, Pulivarthi; Weber, Randal S.; El-naggar, Adel K.

2010-01-01

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Adenoid cystic carcinoma of the lacrimal gland : MYB gene activation, genomic imbalances, and clinical characteristics  

DEFF Research Database (Denmark)

To investigate genetic alterations in lacrimal gland adenoid cystic carcinomas (ACCs) with emphasis on the MYB-NFIB fusion oncogene and its downstream targets, MYB rearrangements, and copy number alterations in relation to clinical data and survival.

von Holstein, Sarah L; Fehr, André

2013-01-01

55

Laryngeal adenoid cystic carcinoma: case report Carcinoma adenóide cístico de laringe: relato de caso  

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CONTEXT: Adenoid cystic carcinomas are malignant tumors that occur in both the major and the minor salivary glands. A laryngeal location is rare because of the paucity of accessory salivary glands in this area. Adenoid cystic carcinomas account for less than 1% of all malignant tumors in the larynx, and only about 120 cases have been reported in the literature. These tumors have a slight female predisposition, and their peak incidence is in the fifth and sixth decades of life. In this article...

André Del Negro; Edson Ichihara; Alfio José Tincani; Albina Altemani; Antônio Santos Martins

2007-01-01

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Adenoid Cystic Carcinoma Mimicking an Oroantral Fistula: A Case Report  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in english Introduction Adenoid cystic carcinoma (ACC) is one of the most frequent malignant salivary gland tumors, which commonly affects the minor salivary glands of the mouth and is rare in the nose and paranasal sinuses. In the maxillary sinus, ACC can mimic inflammatory diseases and has a poor prognosis [...] . Objective To report a case of a 50-year-old man with ACC of the maxillary sinus whose clinical findings in the alveolar ridge mimicked an oroantral fistula. Case Report An excisional biopsy was performed and histopathologic analysis revealed ACC. Lung metastases and residual tumor in the maxillary sinus were detected by imaging methods. In view of the poor general health of the patient, no new surgical intervention was performed and he was only treated by radiotherapy and follow-up. Conclusion Although rare in the maxillary sinus, ACC should be included in the differential diagnosis of lesions affecting this site.

Bárbara Vanessa de Brito, Monteiro; Rafael Grotta, Grempel; Daliana Queiroga de Castro, Gomes; Gustavo Pina, Godoy; Márcia Cristina da Costa, Miguel.

57

Adenoid carcinoma cystic of trachea. A case report  

International Nuclear Information System (INIS)

The tumours of trachea are not frequent. Within them, the adenoid carcinoma cystic is a rare malign tumour and it has been demonstrated that it does not relate to each other significant whit tobacco addiction. In this work we present the case of female patient of 45 years old who went to the urgency room with out of breath accompanied of humid cough with greenish abundant expectoration, fever to 39C and loss of 6 heavy kg in 6 months. The X-ray of thorax sold off in service of urgencies was normal and the doctors imposed treatment no obtaining answer to him. Computerized tomography scanner was made showing the presence of a tracheal lesion

2011-01-01

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Adenoid cystic carcinoma of sublingual glands. Surgery and radiotherapy combination  

International Nuclear Information System (INIS)

The Adenoid Cystic Carcinoma (ACC) or Cilindroma is a strange entity classified by the WHO within the carcinomas of salivary glands. It represents only 1 % of all the wicked tumours of the oral and maxillofacial region although, when making reference to the salivary glands, it constitutes 5% of the parotid, submaxilar and sublingual carcinomas, and about 50% of the smallest ones. The most frequent location is in the palatine glands and its main characteristics are: slow but persistent growth, high rates of local relapse and metastasis at distance originating the death between the first 5 and 10 years in 50-70% of the cases approximately. A case of localization is presented in sublingual gland which was first treated surgically and later with radiotherapy, obtaining good results. (author)

2005-01-01

59

Clinical study on adenoid cystic carcinoma in the nasal cavity  

International Nuclear Information System (INIS)

Objective: To identify pertinent prognostic variables related to adenoid cystic carcinoma (ACC) in the nasal cavity. Methods: A statistic analysis of the clinical results and prognosticators was performed on 38 cases with primary ACC in the nasal cavity. Kaplan-Meier method was used for survival analysis and Log-rank test in comparison, Cox proportional hazard model in multivariate analysis. Results: The 5-, 10- year survival rates were 100% and 88.9% in patients whose lesions disappeared completely after their treatment, whereas 48.0% and 0% in patients with lesion which remained (P0.05). Multivariate analysis revealed that the therapeutic response and clinical stage were independent factors of prognosis. Conclusions: The authors recommend combined therapy for ACC in the nasal cavity. And clinical stage, treatment approach and short-term therapeutic response are identified as ACC predictors

2003-06-01

60

Adenoid cystic salivary gland carcinoma: treatment with irradiation and surgery  

International Nuclear Information System (INIS)

The recrods of 71 patients with adenoid cystic carcinoma of the salivary glands were reviewed to determine the dose response relationships for this aggressive tumor. Local control after treament was determined for all patients and analyzed with respect to extent of surgery and dose of radiation. Of 70 patients who were available for evaluation of local control, 28 (40%) had a local recurrence and 42 (60%) did not. The highest control rates were found in patients who underwent both radiation therapy and surgery. Patients who received a dose equal to or greater than 6,000 rad (60 Gy) in addition to surgery had significantly higher local control rates than those who received less than 6,000 rad (60 Gy). Distant metastases developed in 50% of patients regardless of local control, with the following distribution: 39% lung, 19% bone, and 10% disseminated soft-tissue metastases

1984-05-01

 
 
 
 
61

Cutaneous Adenoid Cystic Carcinoma with Perineural Invasion Treated by Mohs Micrographic Surgery—A Case Report with Literature Review  

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We report a 58-year-old woman with cutaneous adenoid cystic carcinoma arising on the chest treated with Mohs micrographic surgery. The patient remained tumor-free at 24-month follow-up. To date, only six other cases of cutaneous adenoid cystic carcinoma were reportedly managed by Mohs surgery. Cutaneous adenoid cystic carcinoma has low potential for distant metastasis but is notorious for its aggressive infiltrative growth pattern, frequent perineural invasion, and high risk of local recurren...

Xu, Yaohui G.; Hinshaw, Molly; Longley, B. Jack; Ilyas, Humza; Snow, Stephen N.

2010-01-01

62

Evaluation of the relation between adenoids hypertrophy and cranial base angles  

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Full Text Available Background and Aim: Adenoids are normally large in children and their size starts to reduce during adolescence. Hypertrophic adenoids could be associated with allergic reactions. Enlarged adenoids result in nasal breathing difficulties and the child is forced to switch to mouth breathing. Airway obstruction causes postural alterations of jaw, tongue and head, and due to persistent obstruction, patient’s appearance changes to adenoid face. Evaluation of nasopharyngeal space in lateral cephalometic view is a simple and repeatable method for determination of the size and shape of adenoids and nasopharyngeal space which can provide a simple measurement of nasopharyngeal obstruction. The roof of nasopharyngeal space is covered by the sphenoid bone. Thus changes of nasorespiratory resistance by hypertrophic adenoids may affect the cranial base angles. In this study, the relationship between adenoid hypertrophy and cranial base angles was investigated. Materials and Methods: In this descriptive-analytic study, lateral cephalometric views of 7 to 14 y/o patients from the files of orthodontic centers in Rasht city were selected. The radiographs with proper resolution were separated for this research. Adenoid to nasorespiratory ratio (A/N Ratio was determined by Fujioka method and categorized in three groups: A (A/N 0.8, B (0.5adenoid hypertrophy (A and B groups was observed in 66% of cases whereas 34% were normal. The frequency of narrow, normal and wide cranial base angles in lateral ceph views was 28%, 30% and 42% respectively. There was significant difference among different cranial base angle regarding the presence or absence of adenoid hypertrophy (P<0.001. According to Pearson coefficient, there was significant relation between A/N ratio groups and different cranial base angles (R=0.2. Conclusion: Based on the results of this study, little correlation exists between A/N ratio and cranial base angle. Further studies are recommended to investigate the possible effects of other factors such as genetics and the environment.

Dalili Z

2006-07-01

63

Neutron radiotherapy for adenoid cystic carcinoma of minor salivary glands  

International Nuclear Information System (INIS)

Purpose: To examine the efficacy of fast neutron radiotherapy for the treatment of patients with locally advanced, adenoid cystic carcinoma of minor salivary glands and to identify prognostic variables associated with local control, overall survival, and cause specific survival. Methods and Materials: Eighty-four patients having adenoid cystic carcinoma of minor salivary glands were treated with fast neutron radiotherapy during the years 1985-1994. All patients had either unresectable disease or gross disease remaining after attempted surgical extirpation. Seventeen patients had previously received conventional radiotherapy and their subsequent treatment fields and doses for neutron radiotherapy were modified for critical sites (brainstem, spinal cord, brain). Although the median doses (tumor maximum and tumor minimum) only varied by ?10%, treatment portals were substantially smaller in these patients because of normal tissue complication considerations. Twelve patients (13%) had distant metastases at the time of treatment and were only treated palliatively with smaller treatment portals and lower median tumor doses (?80% of the doses delivered to curatively treated patients). Seventy-two patients were treated with curative intent, with nine of these having recurrent tumors after prior full-dose radiotherapy. The median duration of follow-up at the time of analysis was 31.5 months (range 3-115). Sites of disease and number of patients treated per disease site were as follows: paranasal sinus--31; oral cavity--20; oropharynx--12; nasopharynx--11; trachea--6; and other sites in the head and neck--4. Results: The 5-year actuarial local-regional tumor control rate for all patients treated with curative intent was 47%. Patients without involvement of the cavernous sinus, base of skull, or nasopharynx (51 patients) had a 5-year actuarial local-regional control rate of 59%, whereas local-regional control was significantly lower (15%) for patients with tumors involving these sites (p < 0.005). In the latter cases, normal tissue injury considerations precluded delivery of the full dose to the entire tumor. Patients with no history of prior radiotherapy (63 patients) had an actuarial local control rate of 57% at 5 years compared to 18% for those (9 patients) who had been previously irradiated with conventional photons (p = 0.018). Eliminating the dose-limiting factors of prior radiation therapy and/or high risk sites of involvement, the 5-year actuarial local-regional control rate for these 46 patients was 63%, with an actuarial cause specific survival rate of 79%. Lymph node status was a predictor of distant metastasis: 57% of node positive patients developed distant metastases by 5 years compared to 15% of patients with negative nodes (p < 0.0005), and patients who had nodal involvement developed distant metastases sooner than node negative patients (p < 0.0001). The 5-year actuarial overall survival and cause specific survival for the 72 patients treated with curative intent were 59% and 64%, respectively. Conclusions: Fast neutron radiotherapy offers high local-regional control and survival rates for patients with locally advanced, unresectable adenoid cystic carcinomas of minor salivary glands. It should be considered as initial primary treatment for these patients, as well as for other patients in whom surgical extirpation would cause considerable morbidity

1996-08-01

64

Adenoid cystic carcinoma of the esophagus. Complete response to combination chemotherapy.  

Science.gov (United States)

A 55-year-old man had adenoid cystic carcinoma of the esophagus metastatic to the lungs and right supraclavicular fossa. He was treated with local radiation therapy to the esophagus and supraclavicular fossa, followed by combination chemotherapy with doxorubicin, mitomycin C, and 5-fluorouracil (5-FU). After a modest initial response, disease progression was noted in the pulmonary nodules. He was then treated with cisplatin, cyclophosphamide, vincristine, and doxorubicin. After two cycles of this regimen, there was complete regression of his pulmonary nodules, which was sustained for 5 months. A review of 44 literature cases of esophageal adenoid cystic carcinoma contrasted with adenoid cystic carcinoma of salivary gland origin indicated that the esophageal adenoid cystic carcinomas have a high tendency to metastasize (76% of cases) and a much poorer prognosis, with only 23% 1-year survival rate. It was concluded that esophageal adenoid carcinoma is clinopathologically distinct from the salivary gland variant, and that combination chemotherapy may be an effective treatment modality for this cancer. PMID:3004692

Petursson, S R

1986-04-15

65

Does helicobacter pylori have a role in the etiology of adenoid hypertrophy?  

Science.gov (United States)

To investigate whether there is any association between nasopharyngeal reflux and adenoid hypertrophy in children by using 24-h pH monitoring with dual probe and to determine whether Helicobacter pylori simply colonises in adenoid tissue or it is present there temporarily due to extraesophageal reflux. A prospective study at a tertiary referral center. Thirty-two patients who underwent adenoidectomy, aged ranged between 4 and 13 were included. All children with adenoid hypertrophy underwent 24-h pH monitoring with a dual probe. Proximal probe was placed in the nasopharynx. The presence of nasopharyngeal reflux and gastroesophageal reflux were investigated by 24-h pH monitoring. The presence of H. pylori was investigated in adenoidectomy samples by HP-fast test. Of the 32 patients who underwent adenoidectomy, 5 had nasopharyngeal reflux positivity while 27 patients did not show nasopharyngeal reflux positivity with pH monitorisation. Helicobacter pylori could not be detected in 5 nasopharyngeal reflux positive children while 3 of 27 nasopharyngeal reflux negative children showed H. pylori positivity, one of them in the mucosa and others in the core. This study demonstrated the high incidence of nasopharyngeal reflux and gastroesophageal reflux in adenoid hypertrophy and the possible colonisation of H. pylori in the adenoid tissue. This may change the assesment of children with adenotonsillar hypertrophy in near future. However, more placebo controlled and double blind studies and larger series are still needed to support this hypothesis. PMID:24533361

Ayd?n, Emine; Aydo?an, Filiz; Ta?tan, Eren; Arslan, Necmi; Karaca, Gökhan

2014-01-01

66

Clinical study of adenoid cystic carcinoma of the parotid gland  

International Nuclear Information System (INIS)

We report results of a retrospective study of 12 cases of adenoid cystic carcinoma (ACC) in the parotid gland. Local pain was often observed in ACC among other malignant parotid tumors. Although fine-needle aspiration cytology (FNA) was not effective for preoperative diagnosis, frozen section diagnosis (FS) during surgery showed excellent results. Cases with T3 or T4 underwent total or enlarged parotidectomy, but, often showed positive surgical margins. Postoperative radiation therapy seemed useful in these cases and the 5- and 10- year disease-specific survivals in these 12 cases were 90.0% and 80.8%. These compare favorably with other reports in the literature. All 12 cases showed N0 and no cervical relapse with or without neck dissection, indicating little effectiveness in prophylactic neck dissection. Tumor size, positive surgical margins, and perineural invasion are risk factors for this tumor as mention previously. Patients with perineural invasion, especially preoperative facial nerve palsy (T4a), are more likely to fail than those with two other factors, so, it seems conceivable for cases of T4a to undergo more positive treatment with surgery and postoperative radiation. (author)

2007-05-01

67

Adenoid cystic carcinoma of the head and neck  

International Nuclear Information System (INIS)

Between 1976 and 1999, 10 patients with adenoid cystic carcinoma of the head and neck were treated in our department. The patients consisted of 20 females and 20 males. The overall 5-year and 10-year survival rates determined, by Kaplan-Meier analysis, were 74.8% and 47.4%, respectively. The 10-year survival rate of stage I-II was 75.0%, and that of stage III-IV was 33.6%. The prognosis of the patients with stage III-IV was relatively poor. The 10-year survival rates of the patients with nasal and paranasal tumors, and those with maxillary sinus tumors were 25.0% and 0%, respectively. The 10-year survival rate of 15 patients that received combined surgery and radiotherapy was 44.0%, while that of 21 patients that received surgery alone was 48.6%. There was no statistical significance between the two. It was effective, for the patients with lung metastases, to perform pulmonary surgery, for progmosis improvement. We concluded that obtaining clear margins at the initial surgery appeared to be associated with improved survival, combined radiation of less than 50 Gy was not effective, patients with pulmonary metastasis should be treated, if possible. (author)

2001-03-01

68

Pitfalls in magnetic resonance imaging of adenoid cystic carcinoma of the airways  

International Nuclear Information System (INIS)

Involvement of the airways by adenoid cystic carcinoma is best evaluated with multiple sequences of MRI in various planes, as long as the interpreting physician is aware of the potential pitfalls. Adenoid cystic carcinoma (cylindroma) of the airways is an uncommon malignancy which can be treated with positive results by surgery and radiation therapy. Pre-therapeutic assessment is important in determining the extent of local tumor invasion and the involvement of mediastinal structures, especially if surgery is proposed as part of the therapy. A case of adenoid cystic carcinoma of the airways with multi-planar MRI in multiple sequences is presented, together with a discussion of the pitfalls of chemical shift artifact in the distal trachea. (orig.)

1992-04-01

69

Carcinoma adenoide cístico do conduto auditivo externo com envolvimento de mastoide  

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Full Text Available Introdução: O carcinoma adenoide cístico (CAC no conduto auditivo externo é raro, tendo origem nas glândulas ceruminosas. Manifesta-se por otalgia em cerca de 90% dos pacientes. Relato do Caso: Neste artigo relatamos o caso de um paciente com Carcinoma Adenoide Cístico de conduto auditivo externo com envolvimento de mastoide que apresentava paralisia facial periférica. O tratamento é essencialmente cirúrgico, combinado ou não com radioterapia pós-operatória. Os fatores de mau prognóstico são a extensão do tumor, invasão do nervo facial e orelha média e acometimento linfonodal, diminuindo a sobrevida em cinco anos de 59% para 23%.

Tinoco, Paulo

2009-06-01

70

Primary adenoid cystic carcinoma of lung: a case report and review of the literature.  

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Primary adenoid cystic carcinoma of lung is an unusual thoracic neoplasm, which is considered as a slow-growing low-grade malignancy. The primary treatment for this tumor is surgery. The role of radiotherapy, chemotherapy, and targeted agents is less well defined. Here we report a case of inoperable adenoid cystic carcinoma of the lung in a 42-year-old male, presenting with an unusual aggressive behavior. The patient received radiotherapy and oral tyrosine kinase inhibitor imatinib with effective palliation. PMID:23771382

Bhattacharyya, Tapesh; Bahl, Amit; Kapoor, Rakesh; Bal, Amanjit; Das, Ashim; Sharma, S C

2013-01-01

71

Palatal Adenoid Cystic Carcinoma Presenting as Perineural Spread to the Cavernous Sinus  

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Adenoid cystic carcinoma of the hard or soft palate is a slow-growing, insidious disease with a tendency to spread via a perineural mechanism along the palatine branches of the maxillary division of the trigeminal nerve. Such spread may present first as a tumor in the pterygopalatine fossa or cavernous sinus. The purpose of this manuscript is to report three cases of palatal adenoid cystic carcinoma which presented as a mass in the cavernous sinus prior to discovery of the palate primary tumo...

1998-01-01

72

Adenoid cystic carcinoma of hard palate with coincidental metastases to lung and liver.  

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Adenoid cystic carcinoma is the most frequent pathology occurring in the minor salivary glands .It is usually slow growing; however, it can spread via perineural invasion, haematogenous and lymphatogenous metastasis. Most common sites of metastasis are lung and bone. Involvement of the other sites is not common. In this article, we present a woman with coincident lung and liver metastases. PMID:23446045

Akhavan, Ali; Binesh, Fariba; Navabii, Hossein

2013-01-01

73

Adenoid cystic carcinoma of breast and the importance of differentiation from collagenous spherulosis by FNAC  

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Full Text Available We are presenting a case of adenoid cystic carcinoma (ACC of breast in a 66-year-old woman having lump in left breast, admitted to surgical ward of our institute. A diagnosis of ACC of breast was made and subsequently confirmed histopathologically and on immunohistochemistry.

Pandya Amrish

2010-01-01

74

Adenoid cystic carcinoma of the external auditory canal with pulmonary, renal and liver metastases.  

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We report a patient with adenoid cystic carcinoma of the external auditory canal with multiple pulmonary, liver and renal secondaries. She had a palpable left renal mass. The clinical course and treatment of this unusual neoplasm as reported in literature are briefly reviewed.

Matthew R; Subhashini J; Ponnaiya J; Sridhar G; Roul R

1997-01-01

75

Expression of ERBB3 binding protein 1 (EBP1) in salivary adenoid cystic carcinoma and its clinicopathological relevance  

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Abstract Background ERBB3 binding protein 1 (EBP1) gene transfer into human salivary adenoid cystic carcinoma cells has been shown to significantly inhibit cell proliferation and reduce tumor metastasis in mouse models. In the current study, to evaluate if EBP1 is a novel biomarker capable of identifying patients at higher risk of disease progression and recurrence, we examined the EBP1 expression profile in adenoid cystic carcinoma (ACC) patients and analyzed...

Sun Jian; Luo Yixi; Tian Zhen; Gu Liang; Xia Shu; Yu Youcheng

2012-01-01

76

A retrospective study of 18 cases of adenoid cystic cancer at a tertiary care centre in Delhi  

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Context: Adenoid cystic carcinoma (ACC) is a rare neoplasm that usually arises from the salivary, lacrimal, or other exocrine glands. It is characteristically locally infiltrative in nature and has a tendency toward local recurrence, high propensity for perineural invasion, and prolonged clinical course. Aim: To analyze the presentation and natural history of cases of adenoid cystic tumors of salivary glands in our institution; and to compare with the existing literature. Des...

Sharma K; Rathi A; Khurana N; Mukherji A; Kumar V; Singh K; Bahadur A

2010-01-01

77

Growth of the nasopharynx and adenoidal development in Brazilian subjects Crescimento da nasofaringe e desenvolvimento da adenóide em brasileiros  

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The purpose of this research was to study the growth of the nasopharynx and adenoid development. Lateral cephalometric radiographs obtained from 320 white Brazilian subjects between 4 and 16 years of age were used. All the participants were nose breathers and none of them had previously undergone adenoidectomy. Tracings were made from the radiographs and cephalometric measurements were performed. The results showed that adenoid sagital thickness is larger in the age group 4 - 5 years and decr...

Beatriz de Souza Vilella; Oswaldo de Vasconcelos Vilella; Hilton Augusto Koch

2006-01-01

78

Adenoid cystic carcinoma of the head and neck: A retrospective series of 169 cases  

International Nuclear Information System (INIS)

Purpose. - Adenoid cystic carcinoma represents 1% of head and neck cancers. Adenoid cystic carcinomas are slow growing tumours with high potential for local recurrence. Treatment usually associates radiotherapy and surgery, but the role of radiotherapy remains unclear. We report a retrospective multicentric study of the management and prognostic factors of 169 adenoid cystic carcinomas of head and neck. Patients and methods. - Between 1982 and 2010, 169 patients with adenoid cystic carcinoma of the head and neck were referred to the Cercle des oncologues radiotherapeutes du Sud departments of radiotherapy either for primary untreated tumour (n = 135) or for a recurrence of previously treated tumour (n = 34). The site of adenoid cystic carcinoma was: parotid gland (n = 48, 28.4%), minor salivary gland (n = 35, 20.7%), submandibular gland (n = 22, 13%), sinus cavities (n = 22, 13%), other (n = 42, 24.9%). Tumour stages were: T1 (12.4%); T2 (14.2%); T3 (12.4%); T4 (41.4%) and Tx (19.5%). Lymph node involvement was 13% and distant metastasis 8.9%. For adenoid cystic carcinomas of the parotid gland, major nerve involvement was evaluated. Preferential site of metastasis was the lung (87.5%). Treatments were: surgery alone (n = 27), surgery and adjuvant radiotherapy (n = 89), surgery and adjuvant chemoradiotherapy (n 12), exclusive chemoradiotherapy (n = 13), exclusive radiotherapy (n = 14), other associations (n = 5) and no treatment (n = 7). Radiotherapy was delivered through photons (n = 119), neutrons (n = 6), both (n = 4). Two patients had a brachytherapy boost. Median prescribed doses to T and N were respectively 65 Gy and 50 Gy for the 119 photons treated patients. Results. - Mean follow-up was 58 months (range 1-250 months). As of December 1, 2010, 83 patients were alive with no evolutive disease (49%), 35 alive and had recurred, 18 had uncontrolled evolutive disease, 28 had died of adenoid cystic carcinoma and 5 of intercurrent disease. Overall survival and disease free survival were respectively 72% and 72% at 5 years, 53% and 32% at 10 years; 5 and 10-year freedom from local recurrence were 81% and 52% respectively. Nerve involvement was found in 17/48 parotid gland adenoid cystic carcinomas. The Cox model including all patients, showed that surgery (P < 0.001), surgical margins (P = 0.015), nerve involvement (P = 0.0079), length of radiotherapy (P = 0.018), and tumour location (P = 0.041) were associated with disease free survival. Conclusion. - In this large series of adenoid cystic carcinoma of head and neck with a majority of T3-T4 tumours, 10-year survivals were achieved for 50% of patients. Radiotherapy did not impact survival. (authors)

2012-01-01

79

Late-developing tongue adenoid cystic carcinoma after pulmonary metastasectomy: a case report.  

Science.gov (United States)

Adenoid cystic carcinoma (ACC) is a relatively rare epithelial tumor of the salivary glands that accounts for approximately 5 to 10% of all salivary gland neoplasms. The typical clinical and pathological findings of this tumor include slow indolent growth, common local recurrence, and late distant metastasis to lung, brain, bone, liver, thyroid, and spleen. We report a 52-year-old female patient who presented a tongue ACC, 27 months after successful pulmonary ACC resection. PMID:24750665

Sa, Young Jo; Sim, Sung Bo; Kim, Tae-Jung; Moon, Seok Whan; Park, Chan Beom

2014-01-01

80

Adenoid cystic carcinoma of the base of the tongue: Late metastasis to the pancreas.  

Science.gov (United States)

Adenoid cystic carcinoma (ACC) is a relatively rare epithelial tumor of the salivary glands. We present a 64-year-old gentleman with ACC of the tongue who following resection and radiotherapy, presented 10 years later with a lung metastasis and underwent operative intervention and further radiotherapy. Five years later he presented with obstructive jaundice found to be metastatic ACC. We believe this to be the first report of an ACC metastasizing to the pancreas. PMID:22096672

Falk, Gavin A; El-Hayek, Kevin; Morris-Stiff, Gareth; Tuthill, Ralph J; Winans, Charles G

2011-01-01

 
 
 
 
81

Primary pulmonary adenoid cystic carcinoma diagnosed by transthoracic fine needle aspiration cytology  

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Full Text Available Adenoid cystic carcinoma (ACC is an uncommon tumor that very rarely affects the lower respiratory tract and lung parenchyma. Fine needle aspiration cytology (FNAC of primary pulmonary ACC has been rarely described. We report here a 32 year-old female with peripheral ACC, diagnosed by percutaneous transthoracic FNAC. The cytological diagnosis was further confirmed by histological examination of the biopsy specimen.

Nuwal Paras

2008-01-01

82

Adenoid-tonsillectomy to treat visual dysfunction in a child with craniosynostosis.  

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We report a child with isolated saggital synostosis where a gradual deterioration of the P100 component of the pattern reversal visual evoked potential recorded during the day was associated with episodes of upper airway obstruction during sleep that correlated with periods of ICP spiking. Adenoid-tonsillectomy reversed this deterioration with coincident increase in SaO2 and decreased sleep apnoea. PMID:16088255

Liasis, A; Nischal, K K; Leighton, S; Yap, S; Hayward, R; Dunaway, D

2005-01-01

83

Adenoid cystic carcinoma of the esophagus: report of two cases and review of the Chinese literature  

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Full Text Available Abstract Squamous cell carcinoma is the major pathology type of esophageal cancer in China, where adenocarcinoma is rare and adenoid cystic carcinoma (ACC is more rare comparing to the western countries. We report the surgical and pathologic findings of two cases of primary ACC of the esophagus, and review of the Chinese literature of this tumor. Virtual slides The virtual slide(s for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1507582238843246

Guo Xu-feng

2012-12-01

84

Laryngeal adenoid cystic carcinoma: case report / Carcinoma adenóide cístico de laringe: relato de caso  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in portuguese CONTEXTO: Carcinoma adenóide cístico (CAC) é um tumor maligno que ocorre tanto nas glândulas salivares maiores quanto nas menores. Localização laríngea é rara devido à paucidade de glândulas salivares acessórias nesta região. O carcinoma adenóide cístico representa menos de 1% das lesões malignas da [...] laringe e apenas 120 casos foram relatados na literatura. O CAC tem freqüência discretamente superior no sexo feminino e seu pico de incidência ocorre entre a quinta e sexta décadas de vida. Neste artigo, descrevemos um caso de CAC laríngeo e discutimos suas características clínicas e seu tratamento. RELATO DE CASO: Relatamos o caso de CAC numa paciente de 55 anos que apresentava disfonia e dispnéia. Características diagnósticas e avaliação terapêutica são descritas e a conduta clínica definida. Evolução clínica, estratégia terapêutica e procedimento cirúrgico são discutidos, bem como o tratamento adjuvante com radioterapia. O tumor, apesar de radiossensível, não é radiocurável. Abstract in english CONTEXT: Adenoid cystic carcinomas are malignant tumors that occur in both the major and the minor salivary glands. A laryngeal location is rare because of the paucity of accessory salivary glands in this area. Adenoid cystic carcinomas account for less than 1% of all malignant tumors in the larynx, [...] and only about 120 cases have been reported in the literature. These tumors have a slight female predisposition, and their peak incidence is in the fifth and sixth decades of life. In this article, we describe a case of laryngeal adenoid cystic carcinoma and discuss its clinical characteristics and treatment. CASE REPORT: We report on a case of laryngeal adenoid cystic carcinoma in a 55 year-old female patient who presented with dyspnea and hoarseness. Features of the diagnostic and therapeutic evaluation are described and the clinical management of such cases is outlined. The clinical course, definitive treatment strategy and surgical procedure, and also adjuvant treatment with irradiation are discussed. Although the tumor is radiosensitive, it is not radiocurable.

André, Del Negro; Edson, Ichihara; Alfio José, Tincani; Albina, Altemani; Antônio Santos, Martins.

85

Life-Threatening Obstructive Sleep Apnea Caused by Adenoid Hypertrophy in an Infant with Noonan Syndrome  

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Adenoidectomy is a commonly performed surgery in children, even though its effectiveness is still under investigation. However, in children with risk factors such as age under 3 years old, associated comorbidities, or severe obstructive sleep apneas, a high postoperative respiratory morbidity is possible. We report the case of a 15-month-old boy with Noonan syndrome and a complex clinical history, who presented with a life-threatening obstructive sleep apnea due to hypertrophy of the adenoids...

Khirani, Sonia; Leboulanger, Nicolas; Ramirez, Adriana; Fauroux, Brigitte

2012-01-01

86

[A clinical study on the adenoid cystic carcinoma in oral cavity].  

Science.gov (United States)

Two cases of adenoid cystic carcinoma occurred on the palate are reported. They were female and aged 65 and 69 year. They showed expansile growth in association with the bony destruction of maxillary sinus wall. Histologically the case 1 had cribriform pattern and the case 2 had cribriform and tubular pattern, and exhibited perineural invasion of tumor cells in both cases. The radical surgery were conducted, and there were no lymph node metastasis and recurrence. PMID:1966821

Byung, M

1990-03-01

87

Exploring the characteristics of children with obstructive adenoid responding to mometasone fuorate monohydrate: preliminary results.  

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This study aimed at observing the efficacy of mometasone fuorate monohydrate nasal spray on obstructive adenoids in children and identifying the characteristics of responders using a pilot study including children aged 2-11 years, with evidence of more than 50 % obstruction. Allergic rhinitis and nasal obstruction were evaluated on baseline (V0), 6- (V1), and 12-week (V2) visits. Degree of obstruction was evaluated by nasopharyngoscopy at V0 and V2. Subjects received 100 ?g mometasone fuorate daily. Results were compared with those of a matching control group. Nineteen children (8 females, 11 males; 2.25-8.50 years old, mean 4.24 years, median 4.00 years) completed treatment and follow-up adequately. There was 58 % reduction in a clinical score assessing the severity of adenoidal obstruction (P Mometasone furoate monohydrate nasal spray appears to be effective in treating children with obstructive adenoids. The effect seems to be independent of the presence of mild intermittent allergic rhinitis, the age of patient, or the severity of symptoms. PMID:23010795

Bitar, Mohamed A; Mahfoud, Lorice; Nassar, Jihad; Dana, Rouwayda

2013-03-01

88

Nasopharyngeal Adenoid Cystic Carcinoma: Report of Five Cases and Treatment Outcome  

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Full Text Available Background: The present study aimed to report the characteristics and treatment outcomes of five patients with nasopharyngeal adenoid cystic carcinoma and a literature review. Methods: Between 2000 and 2009, five consecutive patients (4 men, 1 woman were diagnosed with nasopharyngeal adenoid cystic carcinoma and treated at our institution. Three patients had stage IVa (T4N0M0 and two patients had stage III (T3N0M0 cancer. Primary treatment consisted of concurrent chemoradiation in three patients andradiotherapy alone in two patients. Surgery was limited to endoscopic biopsy for histological diagnosis. Results: Four patients achieved complete response during or after completion of treatment and remained free of disease for a median of 27 months. Four patients developed local recurrence 8-30 months after initial treatment. The fifth patient is alive and free of disease.Conclusion: The findings of the present study and literature review suggest that local failure is a major problem in adenoid cystic carcinoma of the nasopharynx.

Mahmood Shishegar

2011-04-01

89

Influence of ribosomal protein l39-L in the drug resistance mechanisms of lacrimal gland adenoid cystic carcinoma cells.  

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Background: Cancer constitutes a key pressure on public health regardless of the economy state in different countries. As a kind of highly malignant epithelial tumor, lacrimal gland adenoid cystic carcinoma can occur in any part of the body, such as salivary gland, submandibular gland, trachea, lung, breast, skin and lacrimal gland. Chemotherapy is one of the key treatment techniques, but drug resistance, especially MDR, seriously blunts its effects. As an element of the 60S large ribosomal subunit, the ribosomal protein L39-L gene appears to be documented specifically in the human testis and many human cancer samples of different origins. Materials and Methods: Total RNA of cultured drug-resistant and susceptible lacrimal gland adenoid cystic carcinoma cells was seperated, and real time quantitative RT-PCR were used to reveal transcription differences between amycin resistant and susceptible strains of lacrimal gland adenoid cystic carcinoma cells. Viability assays were used to present the amycin resistance difference in a RPL39-L transfected lacrimal gland adenoid cystic carcinoma cell line as compared to control vector and null-transfected lacrimal gland adenoid cystic carcinoma cell lines. Results: The ribosomal protein L39-L transcription level was 6.5-fold higher in the drug-resistant human lacrimal gland adenoid cystic carcinoma cell line than in the susceptible cell line by quantitative RT-PCR analysis. The ribosomal protein L39-L transfected cells revealed enhanced drug resistance compared to plasmid vector-transfected or null-transfected cells as determined by methyl tritiated thymidine (3H-TdR) incorporation. Conclusions: The ribosomal protein L39-L gene could possibly have influence on the drug resistance mechanism of lacrimal gland adenoid cystic carcinoma cells. PMID:24998577

Ye, Qing; Ding, Shao-Feng; Wang, Zhi-An; Feng, Jie; Tan, Wen-Bin

2014-01-01

90

Sinonasal Adenoid Cystic Carcinoma: Clinical Case Report and Literature Review / Carcinoma Adenoide Quístico Nasosinusal: Caso Clínico y Revisión de la Literatura  

Scientific Electronic Library Online (English)

Full Text Available SciELO Chile | Language: English Abstract in spanish Se presenta el caso de un paciente de sexo masculino de 59 años con carcinoma adenoide quístico nasosinusal. El examen de resonancia magnética reveló la invasión de la órbita derecha y el cerebro a nivel del suelo de la fosa craneal anterior. Debido al gran volumen, se decidió realizar el tratamient [...] o de radio-quimioterapia para disminuir el tamaño de la lesión. Al término de la primera etapa del tratamiento, la reducción del tamaño del tumor fue confirmada por el examen de tomografía computarizada y se decidió realizar una resección quirúrgica con preservación del globo ocular derecho. En la actualidad el paciente se encuentra bajo el control periódico y sin mayores complicaciones. Abstract in english We present the case of a patient, a 59 year-old man, with Sinonasal Adenoid Cystic Carcinoma. Magnetic resonance exam revealed invasion of the right orbit and brain at the level of the anterior cranial fossa floor. Due to the large volume, we decided to perform radio-chemotherapy treatment to dimini [...] sh the size of the lesion. On conclusion of the first stage of treatment, reduction in tumor size was confirmed by computerized tomography exam and we decided to perform surgical resection with right ocular globe preservation. At present the patient is under periodic control and without major complications.

Ilson, Sepúlveda; Carolina, Delgado; Paulo, Flores; Ornella, Salvatori.

91

A rare case of adenoid cystic carcinoma of the nasopharynx manifesting as Horner's syndrome: discussion and review of the literature.  

Science.gov (United States)

Adenoid cystic carcinoma is a malignant tumour involving the salivary glands, rarely developing in the nasopharynx. The biological behaviour of adenoid cystic carcinoma is characterized by slow growth rate, high tendency to local recurrence and metastatic spread. Its histological features are particularly important for prognostic prediction: solid pattern has the worst outcome. Initial presentation of nasopharyngeal adenoid cystic carcinoma with paresis of cranial nerves and Horner's syndrome is infrequent. The Authors present a case of a rare adenoid cystic carcinoma of the nasopharynx, at admission with Horner's syndrome, in a 66-year-old male. Magnetic resonance imaging showed an expansive submucosal lesion of the nasopharynx involving the para-pharyngeal space, tensor and levator veli palati muscles and the apex of petrous bone. Positron emission tomography excluded distant metastasis. Definitive histopathological examination revealed an adenoid cystic carcinoma with mixed cribriform and solid pattern. The patient was treated exclusively with radiotherapy (70 Gy) in 35 fractions with partial reduction of the neoplastic mass. PMID:17957854

Soprani, F; Armaroli, V; Venturini, A; Emiliani, E; Casolino, D

2007-08-01

92

How we do it: laser reduction of peri-tubal adenoids in selected patients with otitis media with effusion.  

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. The literature supports the benefit of adenoidectomy in patients with otitis media with effusion (OME). . It is difficult to clear adenoid tissue from around the Eustachian tubes using curettes and this conventional method of adenoidectomy is contra-indicated in patients with cleft palates. . Laser reduction of peri-Eustachian adenoid tissue without myringotomies or grommet insertion was performed in three patients with OME. Two patients had previous adenoidectomies performed with curettes and one patient had a cleft palate. . In all three patients, the OME resolved and all had closure of the air-bone gap that was maintained during long-term follow-up (14 months-4 years). . This technique resolved OME without the need for myringotomies or grommet insertion and should be considered particularly in patients who have peri-tubal recurrence of adenoidal tissue following conventional adenoidectomy or in patients with cleft palate where there is concern with regards to palatal incompetence. PMID:16441808

Smith, W; Yung, M

2006-02-01

93

Two cases of severe tracheal stenosis due to advanced adenoid cystic carcinoma of the trachea  

International Nuclear Information System (INIS)

Two cases of severe tracheal stenosis due to advanced nonresectable adenoid cystic carcinoma of the trachea were reported. Case 1 was a 38-year-old male who underwent emergency 60Co irradiation following endoscopic YAG laser irradiation. This approach was quite effective. Proton irradiation was effective against tumor recurrence. Case 2 was a 28-year-old female in whom emergency treatment for tracheal obstruction due to edema after laser therapy necessitated transient tracheal intubation. The tracheal stenosis due to recurrent tumor after 60Co irradiation was improved by insertion of an intraluminal permanent stent. (author)

1991-01-01

94

A case report of a primary adenoid cystic carcinoma of the trachea given multidisciplinary treatment  

International Nuclear Information System (INIS)

A case of a 56 year-old man with adenoid cystic carcinoma in the middle and the lower trachea which was successful treated by multidisciplinary treatment is reported. The trachea stenosis was improved from 90 % to 60 % by endoscopic Nd-YAG laser irradiation (total: 20,000 joules). Then bronchial arterial infusion therapy with 15 million units of interferon ?, intratumor injection therapy with 2 million units of interferon ? through a bronchofiberscope, and 660 cGy. of fast neutron irradiation were performed. The tumor disappeared entirely macroscopically, following these multidisciplinary modalities and the patient has been well for four years since treatment started. (author)

1987-01-01

95

Cultivo primario de células ciliadas de adenoides humanos: Un modelo experimental para evaluar la actividad ciliar in vitro Primary culture of human adenoid ciliated cells: An experimental model to evaluate ciliar activity in vitro  

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Full Text Available Introducción: El clearance mucociliar normal es el mecanismo de defensa básico de las vías respiratorias. Sin embargo, los mecanismos de control ciliar aún se desconocen. Con el fin de entenderlo mejor, se han desarrollado diferentes técnicas de cultivo de células ciliadas. Objetivos: Desarrollar un modelo experimental a partir de cultivos primarios de tejido adenoideo y cornete medio. Caracterizarla respuesta a adenosin trifosfato (ATP, agonista conocido de la frecuencia de batido ciliar (FBC. Material y método: Cultivos primarios a partir de explantes de epitelio adenoideo y cornete medio humano. Medición de FBC, con técnica de microfotodensitometría, en condición basal y en respuesta a ATP a diferentes concentraciones. Resultados: La FBC basal (promedio (X ±desv estándar (DE para los cultivos de cornete medio fue 11,9 ±1,5 Hz y para tejido adenoideo fue 10,9 ±1,9 (p >0,05. Se observó un aumento en la FBC en respuesta a ATP, dosis dependiente. No hubo diferencia significativa en la FBC basal ni en la respuesta a ATP entre cultivos de cornete medio y adenoides. Conclusión: El cultivo primario de células ciliadas nasales a partir de explantes de adenoides, es un modelo experimental reproducible, en el que es posible observar actividad ciliary una respuesta funcional concordante con lo descrito en la literaturaIntroduction. Mucociliary clearance constitutes the main defense mechanism of the airway, but the mechanisms of ciliary control are still unknown. With the aim of a better understanding of this process, many ciliated cells culture techniques have been developed. Aims. 1. To develop an experimental model based on primary cultures from adenoid and middle turbinate tissue. 2. To characterize in this model the response to ATP, a known agonist of ciliary beat frequency (CBF. Material and Method. Primary cultures derived from human adenoid tissue and middle turbinate epithelial explants were obtained. CFB was measured by microphotodensitometry, both in basal conditions and in response to ATP at different concentrations. Results. Basal CFB (average (X +- standard deviation (SD for middle turbinate cultures was 11.9 +-1.5 Hz, and for adenoid tissue was 10.9 +-1.9 Hz (p< 0.05. A CBF increase was observed in response to ATP, in a dose-dependent manner. No significant difference in basal CFB or in response to ATP was found between middle turbinate and adenoid cultures. Conclusion. Primary culture of nasal ciliated cells derived from adenoid explants is a reproducible experimental model, in which it is possible to observe both ciliary activity and a functional response in accordance to what has been reported in the literature

Claudia González

2007-08-01

96

Biological behavior and Treatment of Adenoid Cystic Carcinoma in the Head and Neck  

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Biological Behavior and treatment results of 33 patients with Adenoid Cystic Carcinoma (ACC) in the Head and Neck at Yonsei Cancer Center for 10 years between 1971 and 1980 were retrospectively analyzed. Most common, primary site was minor salivary glands such as maxillary sinus, nasal cavity and base of tongue. The typical biological behavior of these tumors was very slowly in growth with long rime of duration (mean 19 months) from I month to 10 years and more frequent of nerve invasion but rare invasion of neck nodes. Local control and failure pattern in the results of treatment, 16 of 17 patients with irradiation alone were seen complete or partial response but 5 cases of loco regional recurrence, 2 cases of failure of neck node and 4 cases of distant metastasis as lung and brain. On the other hand, among 10 cases of surgery and postoperative irradiation, 2 cases of locoreginal failure and 3 cases of distant metastasis as lung and bone. 2 of 4 cases with surgery alone were recurred within primary site. Actuarial overall NED survival at 5 and 10 years were 52.6% and 42.8%, respectively. Survival rate of 10 patients with surgery and postoperative irradiation was more high than 17 patients of radiation alone. Therefore, we have known that surgery with postoperative adjunctive irradiation is most effective treatment modality of adenoid cystic carcinoma in the head and neck. Primary site, treatment modality and with or without nerve and bone invasion have influenced on prognosis

1984-12-01

97

Clinicopathological study of 54 cases of adenoid cystic carcinoma in the head and neck  

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A retrospective analysis was performed on 54 patients with adenoid cystic carcinoma in the head and neck, treated from January 1971 to July l997 in the Kurume University Hospital. The patients consisted of 35 females and 19 males, with a mean age of 59 years. The site of the lesion was the oral cavity in 13, nasal cavity in 11, submandibular gland in 8, parotid gland in 5, paranasal sinus in 3, nasopharynx in 3, oropharynx in 3, external auditory canal in 3, orbita in 2, lip in 1, lacrimal gland in 1 and trachea in 1. The over all 5-year, 10-year and 15-year survival rates as determined by the Kaplan-Meier method were 72%, 53%, and 46%, respectively. There was no relationship between survival rate and the site of the original lesion. According to the histologic criteria reported by Szanto et al., when more than 30% of the neoplasma showed a solid pattern, its treatment outcome appeared poor. In this study, the same tendency was seen. Fifteen patients died of the tumor. Ten died of distant metastasis and 5 died of local recurrence invading the cranium. No patient died of neck metastasis. Adenoid cystic carcinoma was thought to be radioresistant, but recently some authors have reported this tumor as radiosensitive. This study also showed that postoperative radiotherapy was effective, producing an increase in the survival rate. (author)

1997-12-01

98

Adenoid Squamous-Cell Carcinoma (Adenoacanthoma) of the Oral Labial Mucosa. A Clinicopathologic Study of Fifteen Cases.  

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Adenoid squamous-cell carcinoma is a rare variant of squamous-cell carcinoma. It is unreported in the dental literature. Fifteen cases are analyzed. The results suggest that this entity occurs in an older age group (mean age, 56.1 years) and in persons of...

J. F. Nelson J. R. Jacoway R. C. Boyers

1971-01-01

99

Utility of antimicrobial susceptibility testing of multiple Haemophilus influenzae isolates from throat swabs of children with adenoid hypertrophy.  

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Eleven out of 40 children with adenoiditis were colonized with multiple genotypes of Haemophilus influenzae. Heterogeneous antibiotic susceptibility to ampicillin and cotrimoxazole was observed in 6 children. A multiple-colony methodology may potentially help to find the resistant strains of H. influenzae in patients who do not respond to the antibiotic treatment. PMID:24815933

Antos-Bielska, Ma?gorzata; Lau-Dworak, Magdalena; Olszewska-Sosi?ska, Olga; Zielnik-Jurkiewicz, Beata; Trafny, El?bieta A

2014-07-01

100

Evaluación adenoídea mediante nasofaringolaringoscopía: Validación del método Adenoids assessment using nasopharyngolaryngoscopy: A method validation  

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Full Text Available Introducción: La hiperplasia adenoidea es una patología frecuente en la edad pediátrica que determina un elevado porcentaje de los procedimientos quirúrgicos realizados en otorrinolaringología. Sin embargo, losimétodos con los que se cuentan en la actualidad para evaluar el tejido adenoideo y la indicación quirúrgica de su hiperplasia son subjetivos y tienen gran variación entre examinadores. Recientemente se ha propuesto una nueva clasificación que ha sido parcialmente validada en el extranjero, pero no en nuestroimedio. Objetivo: Validar un sistema de clasificación de la hiperplasia adenoidea con estudio endoscópico flexible transnasal. Material yimétodo: Se presentó la grabación de la nasofaringolaringoscopía de 50 pacientes a un grupo de 10 examinadores (5 residentes en formación y 5 otorrinolaringólogos quienes clasificaron las imágenes según laimetodología propuesta. Se analizó el nivel de acuerdo entre los evaluadores utilizando el instrumento estadístico de la correlación intraclase. Resultados: Laimetodología propuesta sería completamente válida al ser implementada por otorrinolaringólogos con alimenos 5 años de experiencia (Intervalo del Coeficiente de Correlación Intraclase entre 0,61 y 0,80 para una confianza de 95%, representando un acuerdo significativamente sustancial entre evaluadores. Al ser utilizada por residentes en su período de formación, su validez sería sóloimoderada, no recomendándose el resultado del examen como parámetro único al decidir una conducta quirúrgica. Conclusiones: La escala de hiperplasia adenoidea propuesta sería válida y objetiva enimanos de operadores experimentados. Resta aún correlacionar sus resultados con clínica respiratoria alta e indicación quirúrgica y con la utilidad de implementar un entrenamiento dirigido en su uso paraimejorar su rendimiento como examen.Introduction. Adenoid hyperplasia is a frequent pediatric pathology that accounts for a large percentage of surgical ORL procedures. However, theimethods for adenoid evaluation and surgical indication in cases of adenoid hyperplasia available today are subjective and greatly variable across examiners. Recently, a new, partially validated classification has been proposed abroad, but a local evaluation is lacking. Aim. To valídate a classification system for adenoid hyperplasia by a trans-nasal flexible endoscopio study Material andimethod. Nasopharyngolaryngoscopy recordings of 50 patients were analyzed by a group of 10 examinéis (5 training residents and 5 otorhinolaryngologists, who classified the images according to the proposedimethodology. The degree of agreement among examinéis was analyzed by intra-class correlation. Resulte. The proposedimethod would be completely reliable and val id if implemented by otorhinolaryngologists with at least 5 years of experience (intra-class correlation coefficient interval between 0.61 and 0.80; 95% confidence level, representing a significant agreement among examiners. It has onlyimodérate validity when implemented by training residents, and the results ofsuch an evaluation are not recommended as the solé parameter when deciding a surgical treatment. Conclusión. The proposed adenoid hyperplasia scale seems to be valid and objective only in the hands of experimented operators. Its results areyet to be correlated with upper airway respiratory pathology and surgical indication, and with the usefulness of implementing a directed training program in order to improve its results as a diagnostic tool.

Carolina Castillo T

2008-08-01

 
 
 
 
101

Evaluación adenoídea mediante nasofaringolaringoscopía: Validación del método / Adenoids assessment using nasopharyngolaryngoscopy: A method validation  

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Full Text Available SciELO Chile | Language: Spanish Abstract in spanish Introducción: La hiperplasia adenoidea es una patología frecuente en la edad pediátrica que determina un elevado porcentaje de los procedimientos quirúrgicos realizados en otorrinolaringología. Sin embargo, losimétodos con los que se cuentan en la actualidad para evaluar el tejido adenoideo y la ind [...] icación quirúrgica de su hiperplasia son subjetivos y tienen gran variación entre examinadores. Recientemente se ha propuesto una nueva clasificación que ha sido parcialmente validada en el extranjero, pero no en nuestroimedio. Objetivo: Validar un sistema de clasificación de la hiperplasia adenoidea con estudio endoscópico flexible transnasal. Material yimétodo: Se presentó la grabación de la nasofaringolaringoscopía de 50 pacientes a un grupo de 10 examinadores (5 residentes en formación y 5 otorrinolaringólogos) quienes clasificaron las imágenes según laimetodología propuesta. Se analizó el nivel de acuerdo entre los evaluadores utilizando el instrumento estadístico de la correlación intraclase. Resultados: Laimetodología propuesta sería completamente válida al ser implementada por otorrinolaringólogos con alimenos 5 años de experiencia (Intervalo del Coeficiente de Correlación Intraclase entre 0,61 y 0,80 para una confianza de 95%, representando un acuerdo significativamente sustancial entre evaluadores). Al ser utilizada por residentes en su período de formación, su validez sería sóloimoderada, no recomendándose el resultado del examen como parámetro único al decidir una conducta quirúrgica. Conclusiones: La escala de hiperplasia adenoidea propuesta sería válida y objetiva enimanos de operadores experimentados. Resta aún correlacionar sus resultados con clínica respiratoria alta e indicación quirúrgica y con la utilidad de implementar un entrenamiento dirigido en su uso paraimejorar su rendimiento como examen. Abstract in english Introduction. Adenoid hyperplasia is a frequent pediatric pathology that accounts for a large percentage of surgical ORL procedures. However, theimethods for adenoid evaluation and surgical indication in cases of adenoid hyperplasia available today are subjective and greatly variable across examiner [...] s. Recently, a new, partially validated classification has been proposed abroad, but a local evaluation is lacking. Aim. To valídate a classification system for adenoid hyperplasia by a trans-nasal flexible endoscopio study Material andimethod. Nasopharyngolaryngoscopy recordings of 50 patients were analyzed by a group of 10 examinéis (5 training residents and 5 otorhinolaryngologists), who classified the images according to the proposedimethodology. The degree of agreement among examinéis was analyzed by intra-class correlation. Resulte. The proposedimethod would be completely reliable and val id if implemented by otorhinolaryngologists with at least 5 years of experience (intra-class correlation coefficient interval between 0.61 and 0.80; 95% confidence level, representing a significant agreement among examiners). It has onlyimodérate validity when implemented by training residents, and the results ofsuch an evaluation are not recommended as the solé parameter when deciding a surgical treatment. Conclusión. The proposed adenoid hyperplasia scale seems to be valid and objective only in the hands of experimented operators. Its results areyet to be correlated with upper airway respiratory pathology and surgical indication, and with the usefulness of implementing a directed training program in order to improve its results as a diagnostic tool.

Castillo T, Carolina; Corssen J, Claudia; Breinbauer K, Hayo; Namoncura P, Carlos.

102

Radiotherapy for advanced adenoid cystic carcinoma: neutrons, photons or mixed beam?  

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Purpose: To compare retrospectively radiotherapy with neutrons, photons, and a photon/neutron mixed beam in patients with advanced adenoid cystic carcinoma of the head and neck. Local control, survival, distant failure, and complications were analyzed. Materials and methods: Between 1983 and 1995, 75 patients with inoperable, recurrent, or incompletely resected adenoid cystic carcinoma of the head and neck received radiotherapy that consisted of either fast 14.1 MV DT neutrons (median dose 16 neutron Gy), linac-based photon irradiation (median dose 64 photon Gy), or both (median dose 8 neutron Gy and 32 photon Gy). Follow-up ranged from 1 to 160 months (median 51 months), and the surviving patients had a minimum follow-up of 3 years at the time of analysis. Results: The actuarial 5-year local control was 75% for neutrons, and 32% for both mixed beam and photons (P=0.015, log-rank). This advantage for neutrons in local control was not transferred to significant differences in survival (P>0.1). The survival is dictated by the tumor diseases due to distant metastases occurring in 29 (39%) of the 75 patients. Positive lymph nodes were the only significant factor (P=0.001) associated with the development of distant metastases although negative lymph nodes did not predict absence of distant metastases, but predicted a delay of occurrence. In multivariate analysis postoperative radiotherapy (P=0.003) and small tumor size (P=0.01) were associated with high local control, while primary therapy (P=0.006) and negative lymph nodes (P=0.01) were associated with longer survival. While acute toxicity was similar in all three radiotherapy groups, severe late grade 3 and 4 toxicity tended to be more prevalent (P>0.1) with neutrons (19%) than with mixed beam (10%) and photons (4%). Conclusion: Fast neutron radiotherapy provides higher local control rates than a mixed beam and photons in advanced, recurrent or not completely resected adenoid cystic carcinoma of the major and minor salivary glands. Neutron radiotherapy can be recommended in patients with bad prognosis with gross residual disease (R2), with unresectable tumors, or inoperable tumors. The type of radiation does not impact survival, which is dominated by the high number of distant metastases

2001-05-01

103

In vitro angiogenesis and expression of nuclear factor ?B and VEGF in high and low metastasis cell lines of salivary gland Adenoid Cystic Carcinoma  

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Abstract Background Adenoid cystic carcinoma is a high malignant carcinoma characterized by intensive local invasion and high incidence of distant metastasis. Although many reports have demonstrated that angiogenesis has played an important role in tumor metastasis, the relationship between metastasis characters and angiogenesis ability in high and low metastasis cell lines of Adenoid cystic carcinoma has rarely been reported. The present study aimed to compare the angiogenes...

Zhang Jiali; Peng Bin

2007-01-01

104

The role of mometasone furoate nasal spray in the treatment of adenoidal hypertrophy in the adolescents: a prospective, randomized, cross-over study.  

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Aim of this work is to find out whether the symptoms attributable to adenoid hypertrophy in adolescents may be treated with intranasal mometasone furoate (MF) application. To learn if adenoid hypertrophy in adolescents may decrease in size with intranasal MF. A prospective, double blind, randomized, cross-over study was conducted in 28 subjects (12-18 years) with adenoidal hypertrophy. Subjects used intranasal MF or placebo for a duration of 6 weeks with a wash out period of 3 weeks. Subjective symptoms and adenoid size were evaluated. At the initiation of the study, there was no significant difference between the mean symptom scores for any of the sinonasal symptoms between the two treatment groups. There was significant improvement in total subjective symptoms (nasal blockage, rhinorrhea, cough, snoring and disruption of quality of life scores) with MF compared with placebo. Analysis of the symptoms separately showed a significant positive effect of MF on all symptoms except for rhinorrhea. Nasal endoscopic evaluation failed to demonstrate any difference in the reduction of the adenoid size between the two groups. MF has significant advantage over placebo for the symptoms attributable to adenoid hypertrophy in adolescents. PMID:23381494

Yilmaz, Huseyin Baki; Celebi, Saban; Sahin-Yilmaz, Asli; Oysu, Cagatay

2013-09-01

105

Adenoid cystic carcinoma of the breast with cerebral metastisation: a clinical novelty.  

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Adenoid cystic carcinoma (ACC) is a rare variant of adenocarcinoma of the breast. It affects mainly minor and major salivary glands, but may also occur in many others locations such as: breast (lung, trachea, cervix and Bartholin's gland. Its prognosis is excellent, contrary to the extra-mammary form. In fact, metastisation is rare (there are only seven clinical cases with metastisation described in literature and the lung is the most affected organ) and when it occurs, generally, there is no axillary node involvement. The authors present the case of a 37-year-old patient, Caucasian, premenopausal, referred to our Cancer Institute with the diagnosis of ACC of the right breast. This case was peculiar because of its multiple and fatal metastisation pattern-nodal, pulmonary, hepatic, osseous and late multifocal cerebral involvement (brain stem and cerebellum). This is the first case-report of ACC with cerebral metastisation. PMID:22679170

Silva, Ines; Tome, Vera; Oliveira, Joao

2011-01-01

106

Adenoid cystic carcinoma of the Bartholin's gland: case report and systematic review of the literature.  

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Adenoid cystic carcinoma (ACC) of the Bartholin's gland is a rare malignancy of the female genital tract. Seventy-nine cases have been reported in the literature. A 40-year-old women presented to our clinic with twice locally recurrent ACC of Bartholin's gland of the left vulva despite hemivulvectomy. Adjuvant radiotherapy was delivered after the third resection. There was no local recurrence after three years follow-up, although she developed lung metastases that remain under control with oral cyclophosphamide. Our case confirms the literature review, which indicates a slow growing tumor with frequent local recurrences (30%) and distant metastases (31%). Adjuvant radiotherapy and/or chemotherapy should be considered in the management of ACC of Bartholin's gland. PMID:22053678

Alsan, Cetin I; Vinh-Hung, V; Eren, F; Abacio?lu, U

2011-01-01

107

Chemotherapy and targeted therapy in adenoid cystic carcinoma of the head and neck: a review.  

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Adenoid cystic carcinoma (ACC) is an uncommon tumor usually arising in the head and neck region, mainly in the salivary glands. It demonstrates an indolent prolonged course and is characterized by perineural invasion. Primary treatment of local and locoregional disease consists mainly of surgery and/or irradiation. During follow-up these patients frequently develop local recurrences and distant metastases, especially in the lung, although long-term survival is possible. The role of chemotherapy in ACC is limited, and studies with only a limited number of patients are performed. In this article we review the literature on chemotherapy regimens, including monotherapy and combination chemotherapy schedules, as well as the new targeted therapies. PMID:20652885

Papaspyrou, Giorgos; Hoch, Stephan; Rinaldo, Alessandra; Rodrigo, Juan P; Takes, Robert P; van Herpen, Carla; Werner, Jochen A; Ferlito, Alfio

2011-06-01

108

[Multiple lung metastases from cutaneous adenoid cystic carcinoma resected 21 years before].  

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A 79-year-old woman whose cutaneous tumor had been resected 21 years and 12 years (local recurrence)before pathologically confirmed as primary cutaneous adenoid cystic carcinoma (ACC), was referred to our hospital for the abnormal shadow on chest X-ray. Chest computed tomography (CT)revealed 3 nodules in the peripheral field of both lungs, which were diagnosed by echo-guided needle biopsy as metastasis from the cutaneous ACC, and were completely resected at 5 months intervals. Any recurrences have not been detected for 2 years after the lung resection. In primary cutaneous ACC, not only complete resection with adequate margin but long-term follow up is recommended. PMID:24322357

Terada, Yoshitaka; Yutaka, Yojiro; Kaneda, Syohei; Noguchi, Susumu; Fukao, Akari; Takahashi, Kenichi; Katakura, Hiromichi; Sakai, Naoki; Yamanaka, Akira; Shirase, Tomoyuki; Saiga, Tatsuyoshi

2013-12-01

109

Primary peripheral pulmonary adenoid cystic carcinoma: report of a case diagnosed by fine needle aspiration cytology.  

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Adenoid cystic carcinoma (ACC) arising from anatomic sites other than the salivary gland is rare and those occurring in the lung are extremely rare. When arising from the lung, the tumor generally arises from extrapulmonary bronchi, originating from bronchial glands. Primary ACC of the lung located peripherally within lung parenchyma is an even rarer event. To the best of our knowledge, this is the first case of primary peripheral pulmonary ACC preoperatively diagnosed by fine needle aspiration cytology (FNAC). We report a case of primary peripheral ACC of the anterior segment of the right upper lobe in a 46-year-old woman diagnosed by FNAC and a brief review of the literature. PMID:20607807

Chon, Soon-Ho; Park, Yong Wook; Oh, Young-Ha; Shinn, Sung Ho

2011-04-01

110

[Homeopathic treatment of adenoid vegetations. Results of a prospective, randomized double-blind study].  

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In a monocenter prospective randomized double-blind clinical trial the efficacy of homeopathic treatment was investigated on children with adenoid vegetations justifying an operation. Patients were treated with either homeopathic remedies such as Nux vomica D200, Okoubaka D3, Tuberculinum D200, Barium jodatum D4 and Barium jodatum D6 or with placebo. The duration of the study for each patient was 3 months. Examination of the ears using a microscope, rhinoscopy, stomatoscopy and pharyngoscopy, as well as tympanometry and audiometry were performed after 4, 8 and 12 weeks. Out of a total of 97 children studied between the ages of 4 to 10 years 82 could be analyzed. At the end of the study no operation was required in 70.7% of the placebo-treated children and in 78.1% of the children treated with homeopathic preparations. These results show no statistical significance. PMID:9378668

Friese, K H; Feuchter, U; Moeller, H

1997-08-01

111

Aggressive adenoid cystic carcinoma with asymptomatic spinal cord compression revealed by a "curtain sign".  

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The authors present a case of unusually aggressive adenoid cystic carcinoma of the head and neck. The patient presented with sciatica one year after initial diagnosis. She was otherwise asymptomatic. Complete work-up for bone involvement, included bone scan and MRI. The patient had painful osteolytic sacral metastasis and asymptomatic thoracic (T5) vertebral metastasis revealed by a typical curtain sign on MRI. The curtain sign, originally described by Trolard, is due to the displacement of the Trolard's membrane with the median ligament attaching the dura to the bone while there is a dorsal displacement and loosening of the posterior longitudinal ligament. The patient benefited from radiotherapy and did not develop respiratory distress, paraplegia or pain but died of liver metastases. PMID:22470582

J, Thariat; Fournier, Ls; C, Badoual; Marcy, Py; M, Housset

2008-01-01

112

Treatment of Locally Advanced Adenoid Cystic Carcinoma of the Trachea With Neutron Radiotherapy  

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Purpose: To examine the efficacy of fast neutron radiotherapy in the treatment of locally advanced adenoid cystic carcinoma (ACC) of the trachea and to compare outcomes with and without high-dose-rate (HDR) endobronchial brachytherapy boost. Methods and Materials: Between 1989 and 2005, a total of 20 patients with ACC of the trachea were treated with fast neutron radiotherapy at University of Washington. Of these 20 patients, 19 were treated with curative intent. Neutron doses ranged from 10.7 to 19.95 Gy (median, 19.2 Gy). Six of these patients received an endobronchial brachytherapy boost using an HDR 192Ir source (3.5 Gy x 2 fractions). Median duration of follow-up was 46 months (range, 10-121 months). Results: The 5-year actuarial overall survival rate and median overall survival for the entire cohort were 89.4%, and 97 months, respectively. Overall survival was not statistically different among those patients receiving an endobronchial boost compared with those receiving neutron radiotherapy alone (100% vs. 68%, p = 0.36). The 5-year actuarial locoregional control rate for the entire cohort was 54.1%. The locoregional control rate was not statistically different among patients who received an endobronchial boost compared with those who received neutron radiotherapy alone (40% vs. 58%, p 0.94). There were no cases of Grade ?3 acute toxicity. There were 2 cases of Grade 3/4 chronic toxicity. Conclusions: Fast neutron radiotherapy is an effective treatment for locally advanced adenoid cystic carcinoma of the trachea, with acceptable treatment-related toxicity

2008-10-01

113

Outcomes and Prognostic Variables in Adenoid Cystic Carcinoma of the Head and Neck: A Recent Experience  

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Purpose: To analyze the recent experience of patients with adenoid cystic carcinoma treated with radiation therapy at Memorial Sloan-Kettering Cancer Center. Methods and Materials: From 1990 to 2004, a total of 59 patients with a diagnosis of primary adenoid cystic carcinoma of the head and neck received radiation therapy at our institution. The subsite distribution was oral cavity, 28% (n = 17); paranasal sinuses, 22% (n = 13); parotid, 14% (n = 8); submandibular, 14% (n = 8); oropharynx, 10% (n = 6); sublingual, 3% (n = 2); nasopharynx, 3% (n = 2); and other, 5% (n = 3). T Stage distribution was T1, 34% (n = 20); T2, 19% (n = 11); T3, 14% (n = 8); and T4, 34% (n = 20). Twenty-nine percent of patients (n = 17) were treated with intensity-modulated radiation therapy; 25% (n =15), with three-dimensional conformal therapy, and the remainder, with conventional techniques. Ninety percent (n = 53) of patients received treatment including the base of skull. Results: Median follow-up for surviving patients was 5.9 years. Five-year and 10-year rates of local control and distant metastases-free survival were 91%/81% and 81%/49%, respectively. Five-year and 10-year rates of disease-free and overall survival were 76%/40% and 87%/65%, respectively. On univariate analysis, stage T4 (p = 0.004) and gross/clinical nerve involvement (p = 0.002) were associated with decreased progression free survival, whereas stage T4 and lymph node involvement were associated with decreased overall survival (p = 0.046 and p < 0.001, respectively). Conclusions: Radiation therapy in combination with surgery produces excellent rates of local control, although distant metastases account for a high proportion of failures. Routine treatment to the base of skull reduces the significance of histologic perineural invasion, but major nerve involvement remains an adverse prognostic factor

2008-04-01

114

Expression of ERBB3 binding protein 1 (EBP1 in salivary adenoid cystic carcinoma and its clinicopathological relevance  

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Full Text Available Abstract Background ERBB3 binding protein 1 (EBP1 gene transfer into human salivary adenoid cystic carcinoma cells has been shown to significantly inhibit cell proliferation and reduce tumor metastasis in mouse models. In the current study, to evaluate if EBP1 is a novel biomarker capable of identifying patients at higher risk of disease progression and recurrence, we examined the EBP1 expression profile in adenoid cystic carcinoma (ACC patients and analyzed its clinicopathological relevance. To understand the underlying anti-metastatic mechanism, we investigated if EBP1 regulates invasion-related molecules. Methods We performed immunohistochemical analysis on 132 primary adenoid cystic carcinoma and adjacent non-cancerous tissues using commercial EBP1, MMP9, E-cadherin and ICAM-1 antibodies. Results were correlated to clinicopathological parameters, long-term survival and invasion-related molecules by statistical analysis. Cell motility and invasiveness of vector or wild-type EBP1-transfected ACC-M cell lines were evaluated using wound healing and Boyden chamber assays. MMP9, E-cadherin and ICAM-1 proteins in these cell lines were detected using western blot assay. Results The expression of EBP1 was significantly higher in non-cancerous adjacent tissues compared with corresponding cancer tissues. The intensity and percentage of cells that reacted with EBP1 antibodies were significantly higher in cases with tubular pattern than those with solid pattern (PPPPPP=0.0002. Conclusions EBP1 expression is reduced in adenoid cystic carcinoma, indicating unfavorable prognosis of ACC patients. Its regulation of MMP9 and E-cadherin protein levels suggests a critical therapeutic potential.

Sun Jian

2012-10-01

115

An unusual presentation of adenoid cystic carcinoma of the minor salivary glands with cranial nerve palsy: a case study  

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Abstract Background Adenoid Cystic Carcinoma (ACC) is a rare tumor entity and comprises about 1% of all malignant tumor of the oral and maxillofacial region. It is slow growing but a highly invasive cancer with a high recurrence rate. Intracranial ACC is even more infrequent and could be primary or secondary occurring either by direct invasion, hematogenous spread, or perineural spread. We report the first case of the 5th and 6th nerve palsy due to caver...

2007-01-01

116

Simultaneous diagnosis of ipsilateral adenoid cystic carcinoma of the lacrimal gland and orbital cavernous hemangioma: case report.  

Science.gov (United States)

ABSTRACT To describe a patient with coexistence of ipsilateral adenoid cystic carcinoma of the lacrimal gland and orbital cavernous hemangioma. The patient presented a 2-month history of painful swelling of left upper eyelid, which did not resolve on a course of oral steroid. On clinical examination, she had moderate medial and inferior dislocation of the eye globe, edema of the temporal superior eyelid and moderate restriction upgaze. Magnetic resonance imaging identified two left orbital tumors: one was a lesion that arose from the lacrimal gland, and the second was a well-defined, ovoid, intraconal mass. The patient underwent lateral orbitotomy and excision of both lesions. Postoperative histological features demonstrated two different lesions: an adenoid cystic carcinoma of the lacrimal gland and a cavernous hemangioma. The clinical presentation of the present case was strongly suggestive of a lacrimal gland malignancy, although the imaging features did not show typical invasive aspects. This is the first report of coexistence of lacrimal gland adenoid cystic carcinoma and cavernous hemangioma in the ipsilateral orbit. PMID:24786224

Strianese, Diego; Ferrara, Mariantonia; Iuliano, Adriana; Bonavolontà, Giulio

2014-08-01

117

Detection of Respiratory Viruses in Nasopharyngeal Swab and Adenoid Tissue from Children Submitted to Adenoidectomy: Pre- and Postoperative Analysis  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in english Introduction The presence of respiratory viruses in lymphoid tissues of the nasopharynx and oropharynx and its impact on recurrent infections and hypertrophy of these tissues are not yet fully understood. Objective To identify and determine the prevalence of major respiratory viruses in nasopha [...] ryngeal secretions and adenoid tissue pre- and postoperatively of children undergoing adenoidectomy. Methods A prospective observational study was conducted in 36 patients under 12 years of age with upper airway lymphoid hypertrophy who were undergoing adenoidectomy, in which various respiratory viruses were investigated using real-time polymerase chain reaction in adenoid tissue and nasopharyngeal secretions collected preoperatively and 30 days postoperatively. Results At least 1 viral agent was isolated in any of the samples collected in 58.3% of children and 25.9% of total samples. Respiratory viruses were identified in 33.8% of preoperative nasopharyngeal specimens and in 19.8% of postoperative secretion. Of the 21 patients with positive results for any respiratory virus, 6 (28.6%) had more than 1 virus. Considering all 36 respiratory viruses found, the main agent isolated was rhinovirus (27.8%), followed by bocavirus (22.2%). Conclusion The virus found more frequently in all samples was rhinovirus. After removal of adenoid tissue, there was a decrease in the prevalence of the virus contained in nasopharyngeal secretion 30 days after surgery.

Osvaldo Vinícius, Biill Primo; Edmir Américo, Lourenço; Saulo Duarte, Passos.

118

Cultivo primario de células ciliadas de adenoides humanos: Un modelo experimental para evaluar la actividad ciliar in vitro / Primary culture of human adenoid ciliated cells: An experimental model to evaluate ciliar activity in vitro  

Scientific Electronic Library Online (English)

Full Text Available SciELO Chile | Language: Spanish Abstract in spanish Introducción: El clearance mucociliar normal es el mecanismo de defensa básico de las vías respiratorias. Sin embargo, los mecanismos de control ciliar aún se desconocen. Con el fin de entenderlo mejor, se han desarrollado diferentes técnicas de cultivo de células ciliadas. Objetivos: Desarrollar un [...] modelo experimental a partir de cultivos primarios de tejido adenoideo y cornete medio. Caracterizarla respuesta a adenosin trifosfato (ATP), agonista conocido de la frecuencia de batido ciliar (FBC). Material y método: Cultivos primarios a partir de explantes de epitelio adenoideo y cornete medio humano. Medición de FBC, con técnica de microfotodensitometría, en condición basal y en respuesta a ATP a diferentes concentraciones. Resultados: La FBC basal (promedio (X) ±desv estándar (DE)) para los cultivos de cornete medio fue 11,9 ±1,5 Hz y para tejido adenoideo fue 10,9 ±1,9 (p >0,05). Se observó un aumento en la FBC en respuesta a ATP, dosis dependiente. No hubo diferencia significativa en la FBC basal ni en la respuesta a ATP entre cultivos de cornete medio y adenoides. Conclusión: El cultivo primario de células ciliadas nasales a partir de explantes de adenoides, es un modelo experimental reproducible, en el que es posible observar actividad ciliary una respuesta funcional concordante con lo descrito en la literatura Abstract in english Introduction. Mucociliary clearance constitutes the main defense mechanism of the airway, but the mechanisms of ciliary control are still unknown. With the aim of a better understanding of this process, many ciliated cells culture techniques have been developed. Aims. 1. To develop an experimental m [...] odel based on primary cultures from adenoid and middle turbinate tissue. 2. To characterize in this model the response to ATP, a known agonist of ciliary beat frequency (CBF). Material and Method. Primary cultures derived from human adenoid tissue and middle turbinate epithelial explants were obtained. CFB was measured by microphotodensitometry, both in basal conditions and in response to ATP at different concentrations. Results. Basal CFB (average (X) +- standard deviation (SD)) for middle turbinate cultures was 11.9 +-1.5 Hz, and for adenoid tissue was 10.9 +-1.9 Hz (p

González, Claudia; Sánchez, Trinidad; Fonseca, Ximena; Villalón, Manuel.

119

Results of fast neutron therapy of adenoid cystic carcinoma of the salivary glands  

International Nuclear Information System (INIS)

Purpose: The slowly growing adenoid cystic carcinomas show a poor response after conventional photon therapy. An alternative could be the irradiation with fast neutrons. In this study we want to evaluate the advantage of neutron therapy in comparison to photon therapy. Material and methods: Between 1986 and 1995, 72 patients with adenoid cystic carcinomas of the salivary glands were treated in Muenster with fast neutrons by a d, T-14 MeV neutron generator. Median age of the patients was 54 years. 91,6 % of the patients were surgically pretreated. All of them had either recurrences or macroscopic tumor rests prior to neutron therapy. The total neutron dose applied was between 10.02 Gy and 15,03 Gy with single doses of 1,67 Gy given in a hypofractionated fashion three times a week. Median follow-up was 50 months. Results: 52,7 % of the patients achieved a complete remission after neutron therapy and 47,3 % a partial remission. The survival probability, calculated by the Kaplan-Meier method, was 86 % after one year, 73 % after two years and 53 % after five years. The recurrence-free survival was 83 % after one year, 71 % after two years and 45% after five years. The univariate Kaplan - Meier analysis showed a significant correlation (p<0,05) between different prognostic factors (tumorvolume, dosage and histologic grading) and survival. The early side effects observed were skin reactions I deg. -II deg. (57 %) (EORTC/RTOG) and mucositis I deg. -II deg. (32 %). Two patients suffered from radiation induced mucosal ulcers III deg. -IV deg. . Late effects seen included teleangiectasia I deg. -II deg. in 67 %, subcutaneous fibrosis in 36 % and xerostomia in I deg. -II deg. (32 %). Conclusion: Neutron beam therapy seems to be an effective treatment in these selected patients. The observed control rate was 73,4%, compared to an average local control rate of 28% of patients treated with photons. The appeared side effects were mild to moderate

1997-01-01

120

Multiple cutaneous metastases: a rare and late sequelae of lacrimal gland adenoid cystic carcinoma.  

Science.gov (United States)

Primary cutaneous adenoid cystic carcinoma (ACC) is an uncommon malignancy with approximately 60 cases reported in the literature. Metastatic ACC to the skin is even less frequent with eight previously published cases, including only one arising from the lacrimal gland. We report a case of a 61-year-old male, who developed multiple cutaneous metastases to the scalp and back from a lacrimal gland ACC 21 years after the initial diagnosis. Initially, in the absence of the past clinical history, the cutaneous lesions were interpreted as primary ACC of the skin. Histopathologically, the metastatic lesions were poorly circumscribed dermal and subcutaneous nodules that were composed of islands of basaloid epithelial cells with ducts and cribriform pattern, mucinous stroma and prominent perineural invasion. Histomorphologically, the cutaneous tumors were similar to the primary ACC. The cutaneous metastases were preceded by tumor dissemination to the lung and other visceral organs, and ultimately led to patient's demise. This report illustrates the importance of juditious clinico-pathologic correlation and raises awareness regarding prolonged latency of cutaneous metastases in patients with visceral ACC. PMID:23899266

Jedrych, Jaroslaw; Galan, Anjela

2013-03-01

 
 
 
 
121

Adenoid cystic carcinoma of the nasal cavity and paranasal sinuses: a meta-analysis.  

Science.gov (United States)

Objectives To identify independent predictors of outcome in patients with adenoid cystic carcinoma (ACC) of the paranasal sinuses and skull base. Design Meta-analysis of the literature and data from the International ACC Study Group. Setting University-affiliated medical center. Participants The study group consisted of 520 patients, 99 of them from the international cohort. The median follow-up period was 60 months (range, 32 to 100 months). Main Outcome Measures Overall survival (OS) and disease-specific survival (DSS). Results The 5-year OS and DSS of the entire cohort were 62% and 67%, respectively. The local recurrence rate was 36.6%, and the regional recurrence rate was 7%. Distant metastasis, most commonly present in the lung, was recorded in 106 patients (29.1%). In the international cohort, positive margins and ACC of the sphenoid or ethmoidal sinuses were significant predictors of outcome (p < 0.001). Perineural invasion and adjuvant treatment (radiotherapy or chemoradiation) were not associated with prognosis. Conclusion Tumor margin status and tumor site are associated with prognosis in ACC of the paranasal sinuses, whereas perineural invasion is not. Adjuvant treatment apparently has no impact on outcome. PMID:24436900

Amit, Moran; Binenbaum, Yoav; Sharma, Kanika; Naomi, Ramer; Ilana, Ramer; Abib, Agbetoba; Miles, Brett; Yang, Xinjie; Lei, Delin; Kristine, Bjoerndal; Christian, Godballe; Thomas, Mücke; Klaus-Dietrich, Wolff; Fliss, Dan; Eckardt, André M; Chiara, Copelli; Sesenna, Enrico; Frank, Palmer; Patel, Snehal; Gil, Ziv

2013-06-01

122

Recurrent adenoid cystic carcinoma in the liver: a repeated laparoscopic surgical approach.  

Science.gov (United States)

Adenoid cystic carcinoma (ACC) is characterized by a particularly aggressive behavior even many years after resection of primary tumor. The evolution of metastasis dramatically affects the final outcome but resection should always be evaluated. Herein is described a case of aggressive ACC of the parotid gland in a 30-year-old female. She developed local recurrence and lung metastases; then, she also developed two liver metastasis 112 and 132 months after the resection of the primitive cancer of the parotid gland. Both lesions were successfully managed by a laparoscopic approach. Intra-abdominal adhesions after the first surgery were mild, allowing an easier access for the second laparoscopic liver resection. At 1 year follow-up, the patient is liver disease free with a stable lung disease. To our knowledge, this is the first report of a double laparoscopic liver resection for parotid gland's ACC metachronous metastases. Patients with resected ACC need a strict and lifelong follow-up after the resection of the primitive cancer. Also for ACC, a laparoscopic approach to liver metastasis should always be considered as a viable alternative to open surgery. In our experience of over 90 cases, laparoscopic surgery causes less adhesions, allowing an easier approach for repeated resections. PMID:21647796

Scuderi, Vincenzo; Ceriello, Antonio; Romano, Marina; Migliaccio, Carla; Marino Marsilia, Giuseppina; Calise, Fulvio

2011-12-01

123

Molecular characteristics of homologous salivary adenoid cystic carcinoma cell lines with different lung metastasis ability.  

Science.gov (United States)

Although the homologous salivary adenoid cystic carcinoma (SACC) cell lines SACC-83 and SACC-LM have already been used as SACC models to investigate the underlying mechanisms of metastasis, the molecular features of these SACC cell lines remain unclear. We screened 136 genes related to metastasis in order to investigate the biological and molecular properties of these two cell lines by short tandem repeat (STR) profiling, immunostaining, transwell invasion assay, real-time PCR and western blotting. STR and immunostaining results showed that SACC-83 and SACC-LM are homologous cancer cell lines, derived from adenoepithelial cells and, to date, are not contaminated by each other or other cancer cell lines. Transwell invasion assay results showed that SACC-LM had increased invasion ability compared to SACC-83. 29 of the 136 differentially expressed genes including EREG, S100P, cyclooxygenase (COX)-2, phospho-Akt (p-Akt), matrix metalloproteinase (MMP)-1, MMP-2, MMP-3, MMP-9, MMP-13 and MMP-14 were found following gene screening in SACC-83 and SACC-LM cells. Compared with SACC-83, SACC-LM presents higher expression of COX-2, S100P and lower expression of MMP-2, p-Akt, which could be candidates for identifying the homologous pair cell lines. PMID:23673996

Wang, Lin; Wang, Yixiang; Bian, Huan; Pu, Yinfei; Guo, Chuanbin

2013-07-01

124

Adenoid cystic carcinoma of the breast: A case report and literature review  

Science.gov (United States)

Adenoid cystic carcinoma (ACC) is a rare malignant tumor of the breast that occurs in <0.1% of all patients diagnosed with breast cancer. The mean patient age at the time of diagnosis is 50–60 years. Typically, the tumor presents as a subareolar mass or as pain in the breast. While the radiological appearances of ACC are generally non-specific, the diagnosis can be made on fine-needle aspiration cytology. In the present study, a 58-year-old female patient was admitted to the Department of Radiation Oncology (Karadeniz Technical University, Faculty of Medicine, Trabzon, Turkey) with complaints of pain in the upper outer quadrant of the right breast. An excision biopsy of a lump in the upper outer quadrant revealed ACC, and perineural invasion was present. Subsequently, the patient underwent breast conservation surgery and sentinel lymph node dissection. Pathology from the second surgery depicted ACC in the form of microscopic foci around the initial surgical cavity, with two reactive sentinel lymph nodes and the closest negative margin at 2 mm. The patient was treated with radiotherapy following the surgery. No recurrence and metastasis were found after 20 months of follow-up. In conclusion, mammary ACC is a rare malignant neoplasm of the breast. Although surgery is the main treatment, the optimal adjuvant treatment of ACC of the breast has not yet been determined due to its low incidence.

CANYILMAZ, EMINE; USLU, GONCA HANEDAN; MEMIS, YAHYAHAN; BAHAT, ZUMRUT; YILDIZ, KADRIYE; YONEY, ADNAN

2014-01-01

125

Adenoid Cystic Carcinoma of the Nasal Cavity and Paranasal Sinuses: A Meta-Analysis  

DEFF Research Database (Denmark)

Objectives To identify independent predictors of outcome in patients with adenoid cystic carcinoma (ACC) of the paranasal sinuses and skull base. Design Meta-analysis of the literature and data from the International ACC Study Group. Setting University-affiliated medical center. Participants The study group consisted of 520 patients, 99 of them from the international cohort. The median follow-up period was 60 months (range, 32 to 100 months). Main Outcome Measures Overall survival (OS) and disease-specific survival (DSS). Results The 5-year OS and DSS of the entire cohort were 62% and 67%, respectively. The local recurrence rate was 36.6%, and the regional recurrence rate was 7%. Distant metastasis, most commonly present in the lung, was recorded in 106 patients (29.1%). In the international cohort, positive margins and ACC of the sphenoid or ethmoidal sinuses were significant predictors of outcome (p <0.001). Perineural invasion and adjuvant treatment (radiotherapy or chemoradiation) were not associated withprognosis. Conclusion Tumor margin status and tumor site are associated with prognosis in ACC of the paranasal sinuses, whereas perineural invasion is not. Adjuvant treatment apparently has no impact on outcome.

Bjørndal, Kristine; Londero, Stefano Christian

2013-01-01

126

Pattern of failure and role of radiotherapy in adenoid cystic carcinoma of the head and neck  

International Nuclear Information System (INIS)

This retrospective study reviewed 55 patients with adenoid cystic carcinoma of the head and neck who were treated with radiotherapy for primary sites between 1980 and 1998. The treatment modality consisted of radiotherapy combined with surgery in 44 patients and radiotherapy without surgery in 11. Chemotherapy was also administered to 9 operated and 6 unoperated patients. The range of prescribed doses was 25-65 Gy (median 50 Gy) for patients who underwent surgery, and 60-70 Gy (median 65 Gy) for those who did not. Local failure occurred in 16 patients (29%), and 20 (36%) developed distant metastasis, which were common types of failure. Although not statistically significant different, local relapse free rates of early stage tumors were better than those of advanced stage tumors (p=0.08). The local relapse free rates were influenced by the primary sites (major vs. minor salivary glands) (p=0.04). These factors, however, had no impact on survival. Three patients developed recurrences in the skull base probably thorough perineural spread. Neck failure was also uncommon type of recurrence, occurring in only two patients. We also discuss elective irradiation to the neck nodes and the skull base. (author)

2001-12-01

127

Intracranial extension of adenoid cystic carcinoma of the palate: a case report  

International Nuclear Information System (INIS)

Intracranial involvement by adenoid cystic carcinoma (ACC) is very rare and there is no report of intracranial extension from the palate ACC in Korea. Intracranial involvement can occur in one of three ways: direct extension, perineural spread, and hematogenous spread. A case report of a 35-year-old woman with intracranial ACC is presented. Initially she had ACC of the right palate and was treated by surgery and postoperative radiation therapy. Three years and 10 months later, the paresthesia in the distribution of ophthalmic and maxillary branch of right trigeminal nerve developed without evidence of recurrence in CT scan. Ptosis and total ophthalmoplegia developed sequentially and the second operation was performed. It was suggested that the tumor was spread perineurally along the trigeminal nerve into the Gasserian ganglion and then cavernous sinus and orbit. Seven years and 6 months after the first operation, direct intracranial extension into the right temporal lobe developed via sphenoid bone, sphenoid sinus and temporal bone and the third operation was done. And then Jung metastasis was diagnosed. She is alive for 9 years 5 months after first operation

1999-12-01

128

Microglandular adenosis with transition into adenoid cystic carcinoma of the breast.  

Science.gov (United States)

Microglandular adenosis (MGA) is a well-recognized, if rare and incompletely characterized, entity in which carcinoma is rarely thought to develop. We report 17 cases in which patterns of adenoid cystic carcinoma (ACC) coexisted with MGA. Immunocharacterization with beta-catenin, E-cadherin, cytokeratins (AE1/AE3), epithelial membrane antigen, S-100 protein, smooth muscle actin, and vimentin was also performed. Most cases had areas of invasive ACC characterized by its defining dual-lumen types. Some cases of ACC appeared to have expanded glands intermingled within the MGA, whereas in other cases ACC formed a transition with the characteristic small, gland-like spaces of MGA. MGA and "atypical MGA" stained irregularly and similarly to that seen in myoepithelium with the three markers of myoepithelial cells in breast: S-100 protein, smooth muscle actin, and vimentin. These markers were also positive in the more solid elements of the ACC. Our study suggests that ACC may develop in a background of and in continuity with MGA. Altered myoepithelial cells appear to be the major neoplastic element in both ACC and "atypical MGA." "Atypical MGA" with transition to ACC may show histologic patterns and an immunohistochemical profile similar to that of ACC. These lesions might be best interpreted as ACC in situ. Both MGA and ACC of the breast grow in an expansile and diffusely infiltrative pattern without having significant metastatic capacity. Their unusual interaction with the surrounding stroma may play a role in this benign biologic behavior. PMID:12883237

Acs, Geza; Simpson, Jean F; Bleiweiss, Ira J; Hugh, Judith; Reynolds, Carol; Olson, Sandy; Page, David L

2003-08-01

129

Inhibition of autophagy augments chemotherapy in human salivary adenoid cystic carcinoma.  

Science.gov (United States)

Although cisplatin (DDP)-based adjuvant chemotherapy is widely used in the treatment of salivary adenoid cystic carcinoma (SACC), SACCs have developed resistance to cisplatin, resulting in chemotherapy failure. Autophagy serves as a critical adaptive response, which was increased in tumor cells in chemotherapy. However, the function of autophagy is not clear in SACC. In this study, apoptosis induced by DDP in SACC high metastatic cell line (ACC-M) was revealed using MTT assay, flow cytometry, and caspase-3 immunoblotting. The autophagy activation induced by DDP treatment was measured by transmission electron microscopy, green fluorescent protein-light chain 3 plasmid transfection LC3 immunoblotting and p62 immunoblotting. 3-methyladenine (3-MA) or small interference RNA targeting beclin 1 (beclin 1 siRNA) inhibited autophagy and significantly enhanced DDP-induced apoptosis. ACC-M xenografts in nude mice further verified the synergistic effect of DDP and 3-MA. In conclusion, autophagy activation was caused to protect cancer cells from DDP-induced apoptosis and autophagy inhibition could be a promising strategy for adjuvant chemotherapy in SACC. PMID:24118359

Jiang, Licheng; Huang, Shengyun; Zhang, Dongsheng; Zhang, Bin; Li, Keyi; Li, Wengang; Zhang, Shizhou; Zhang, Weidong; Zheng, Peihui

2014-04-01

130

Recurrent prognostic factors and expression of GLUT-1, PI3K and p-Akt in adenoid cystic carcinomas of the head and neck: Clinicopathological features and biomarkers of adenoid cystic carcinoma  

Digital Repository Infrastructure Vision for European Research (DRIVER)

The purpose of this study was to explore the factors associated with the recurrence of adenoid cystic carcinomas (ACCs). We examined the recurrence values of clinicopathological variables and GLUT-1, p-Akt and PI3K expression in 42 patients with ACC. Of the 42 patients, 17 developed recurrence following initial surgery. The positive rates of GLUT-1, PI3K and p-Akt protein expression in ACC were 38.1, 38.1 and 50.0%, respectively. The expression of GLUT-1, p-Akt or PI3K protein in ACC was high...

Fang, Jin; Bao, Yang-yang; Zhou, Shui-hong; Luo, Xing-mei; Yao, Hong-tian; He, Jian-feng; Wang, Qin-ying

2012-01-01

131

Results of fast neutron therapy of adenoid-cystic carcinomas of the head and neck at the neutron therapy facility Hamburg-Eppendorf  

Energy Technology Data Exchange (ETDEWEB)

Between 1977 and 1987, 30 patients with adenoid-cystic carcinomas of the head and neck region were treated, at the Hamburg-Eppendorf neutron therapy facility, with a 14 MeV-DT-generator. The present review deals with 15 patients treated before October 1986 e.g. with follow up longer than one year. These results, although preliminary, tend to confirm that fast neutrons is the best irradiation modality of adenoid-cystic carcinomas of the head and neck-region, especially when surgery is not possible, or cannot be radical.

Schwarz, R.; Brockmann, W.P.; Junker, A.

1989-04-01

132

Results of fast neutron therapy of adenoid-cystic carcinomas of the head and neck at the neutron therapy facility Hamburg-Eppendorf  

International Nuclear Information System (INIS)

Between 1977 and 1987, 30 patients with adenoid-cystic carcinomas of the head and neck region were treated, at the Hamburg-Eppendorf neutron therapy facility, with a 14 MeV-DT-generator. The present review deals with 15 patients treated before October 1986 e.g. with follow up longer than one year. These results, although preliminary, tend to confirm that fast neutrons is the best irradiation modality of adenoid-cystic carcinomas of the head and neck-region, especially when surgery is not possible, or cannot be radical. (orig.)

1989-04-01

133

Identification of intracellular bacteria in adenoid and tonsil tissue specimens: the efficiency of culture versus fluorescent in situ hybridization (FISH).  

Science.gov (United States)

Monocyte/macrophage cells from human nasopharyngeal lymphoid tissue can be a source of bacteria responsible for human chronic and recurrent upper respiratory tract infection. Detection and characterization of pathogens surviving intracellularly could be a key element in bacteriological diagnosis of the infections as well as in the study on interactions between bacteria and their host. The present study was undertaken to assess the possibility of isolation of viable bacteria from the cells expressing monocyte/macrophage marker CD14 in nasopharyngeal lymphoid tissue. Overall, 74 adenotonsillectomy specimens (adenoids and tonsils) from 37 children with adenoid hypertrophy and recurrent infections as well as 15 specimens from nine children with adenoid hypertrophy, which do not suffer from upper respiratory tract infections (the control group), were studied. The suitability of immunomagnetic separation for extraction of CD14(+) cells from lymphoid tissue and for further isolation of the intracellular pathogens has been shown. The coexistence of living pathogens including Haemophilus influenzae, Staphylococcus aureus, and Streptococcus pyogenes with the bacteria representing normal nasopharyngeal microbiota inside CD14(+) cells was demonstrated. Twenty-four strains of these pathogens from 32.4 % of the lysates of CD14(+) cells were isolated. Concurrently, the fluorescent in situ hybridization (FISH) with a universal EUB388, and the species-specific probes demonstrated twice more often the persistence of these bacterial species in the lysates of CD14(+) cells than conventional culture. Although the FISH technique appears to be more sensitive than traditional culture in the intracellular bacteria identification, the doubts on whether the bacteria are alive, and therefore, pathogenic would still exist without the strain cultivation. PMID:23934353

St?pi?ska, M; Olszewska-Sosi?ska, O; Lau-Dworak, M; Zielnik-Jurkiewicz, B; Trafny, E A

2014-01-01

134

Literature review on the role of radiotherapy in the treatment of nasopharyngeal cystic adenoid carcinomas about two cases  

International Nuclear Information System (INIS)

The authors discuss the characteristics and the radiotherapy treatment procedures of cystic adenoid carcinomas, and more precisely the treatment of two of such cases of nasopharyngeal carcinomas. The first one had an incomplete resection surgery followed by curing radiotherapy: he has then been in local-regional control situation for 8 months. The second one had lung metastases, was treated chemotherapy and radiotherapy (decompressive treatment), and died six months after diagnosis. Radiotherapy is considered to be the treatment basis, whereas chemotherapy is a matter of controversy. Short communication

2011-10-01

135

Management of Adenoid Cystic Carcinoma of the Breast: A Rare Cancer Network Study  

Energy Technology Data Exchange (ETDEWEB)

Background: Mammary adenoid cystic carcinoma (ACC) is a rare breast cancer. The aim of this retrospective study was to assess prognostic factors and patterns of failure, as well as the role of radiation therapy (RT), in ACC. Methods: Between January 1980 and December 2007, 61 women with breast ACC were treated at participating centers of the Rare Cancer Network. Surgery consisted of lumpectomy in 41 patients and mastectomy in 20 patients. There were 51(84%) stage pN0 and 10 stage cN0 (16%) patients. Postoperative RT was administered to 40 patients (35 after lumpectomy, 5 after mastectomy). Results: With a median follow-up of 79 months (range, 6-285), 5-year overall and disease-free survival rates were 94% (95% confidence interval [CI], 88%-100%) and 82% (95% CI, 71%-93%), respectively. The 5-year locoregional control (LRC) rate was 95% (95% CI, 89%-100%). Axillary lymph node dissection or sentinel node biopsy was performed in 84% of cases. All patients had stage pN0 disease. In univariate analysis, survival was not influenced by the type of surgery or the use of postoperative RT. The 5-year LRC rate was 100% in the mastectomy group versus 93% (95% CI, 83%-100%) in the breast-conserving surgery group, respectively (p = 0.16). For the breast-conserving surgery group, the use of RT significantly correlated with LRC (p = 0.03); the 5-year LRC rates were 95% (95% CI, 86%-100%) for the RT group versus 83% (95% CI, 54%-100%) for the group receiving no RT. No local failures occurred in patients with positive margins, all of whom received postoperative RT. Conclusion: Breast-conserving surgery is the treatment of choice for patients with ACC breast cancer. Axillary lymph node dissection or sentinel node biopsy might not be recommended. Postoperative RT should be proposed in the case of breast-conserving surgery.

Khanfir, Kaouthar, E-mail: kaouthar.khanfir@rsv-gnw.ch [Hopital de Sion, CHCVs, Sion (Switzerland); Kallel, Adel [Institut Gustave Roussy, Villejuif (France); Villette, Sylviane [Centre Rene Huguenin, Paris (France); Belkacemi, Yazid [CHU Henri Mondor, Centre Oscar Lambret, Lille (France); Vautravers, Claire [Centre George Francois Leclerc, Dijon (France); Nguyen, TanDat [Institut Jean Gaudinot, Reims (France); Miller, Robert [Mayo Clinic, Rochester, Minnesota (United States); Li Yexiong [Peking Union Medical College, Beijing (China); Taghian, Alphonse G. [Massachusetts General Hospital, Boston, Massachusetts (United States); Boersma, Liesbeth [Maastricht University Medical Center (MAASTRO clinic), Maastricht (Netherlands); Poortmans, Philip [Dr. Bernard Verbeeten Institute, Tilburg (Netherlands); Goldberg, Hadassah [Western Galilee Hospital-Nahariya, Nahariya (Israel); Vees, Hansjorg [Hopitaux Universitaires de Geneve, Geneva (Switzerland); Senkus, Elzbieta [Medical University of Gdansk, Gdansk (Poland); Igdem, Sefik; Ozsahin, Mahmut [Istanbul Bilim University, Istanbul (Turkey); Jeanneret Sozzi, Wendy [Centre Hospitalier Universitaire Vaudois, Lausanne (Switzerland)

2012-04-01

136

CT diagnosis of adenoid cystic carcinoma of the nasal cavity and paranasal sinus  

International Nuclear Information System (INIS)

Purpose: To assess CT findings and their clinical value in the diagnosis of adenoid cystic carcinoma (ACC) of the nasal cavity and paranasal sinus. Materials and methods: Pre-treatment CT findings in 17 histologically proven cases of ACC of the nasal and paranasal sinus were reviewed. 3 cases had plain CT, 2 cases both pre- and post-contrast enhanced CT, and 12 cases contrast enhanced CT. There were 18 axial and 16 coronal scans. Results: Tumors originated from and localized in the nasal cavity in 2 cases. In 15 cases, tumors were located in maxillary sinus and invaded adjacent organs or/and structures, including ipsilateral ethmoid sinus, sphenoid sinus and nasal cavity, contralateral maxillary sinus, orbit, palate, infratemporal fossa, pterygopalatine fossa, parapharyngeal space, inferior orbital fissure and foramen oval. In 7 cases, lesions invaded intracranial structures as well as the cavernous sinus. Altogether there were 2 cases of stage I, 3 cases stage III, and 12 cases stage IV. Adjacent bony changes were found in 16 cases, with bony remodeling (4 cases) and bony erosion combined with expansion (12) (71%). The diameter of the mass was larger than 5 cm in 71% of the cases. In 41% of the cases, tumors were irregular in shape, mottled pattern of lucencies within the tumor was shown in 82% of cases. Scattered calcification could be identified in 3 cases. Conclusion: Most of ACC of the nasal cavity and paranasal sinus had mottle pattern of lucencies within the tumor, irregular in shape, adjacent bony remodeling and/or erosive destruction. These findings indicate the histologic and biologic characteristics of the tumor with slow growing and perineural invasion. Apart from axial scan, coronal scan and contrast administration are mandated for the diagnosis and staging ACC

1998-03-01

137

Prognostic factors affecting the clinical outcome of adenoid cystic carcinoma of the head and neck  

International Nuclear Information System (INIS)

Adenoid cystic carcinoma (ACC) is an uncommon tumor, constituting approximately 10% of all head and neck tumors. Classically, ACC has been described as a tumor with indolent, but persistent and recurrent, growth and late onset of metastases, leading eventually to death. This study assessed the prognostic factors affecting the clinical outcome in patients with ACC in the head and neck region. We performed a retrospective study of 42 patients who underwent primary tumor resection or radiotherapy with curative intent and evaluated the clinical parameters, treatment and clinical outcomes. Forty-two patients (18 males and 24 females with a median age of 65 years) received curative treatment. The overall 3- and 5-year survival was 87.4% and 55.3%, respectively, whereas the 3- and 5-year disease-free survival was 64.3% and 36.1%, respectively. Of the 32 patients in whom recurrence could be evaluated, 18 (56.3%) developed distant metastases, with the lung (72.2%) being the most common site. Perivascular invasion influenced metastasis to the lung with borderline significance (P=0.053). The recurrence rate was higher (P=0.045) in patients with high-grade tumor. The status of lymph node metastasis was significantly associated with overall survival (P=0.030). High tumor grade and lymph node involvement were predictive of recurrence and overall survival, respectively. Despite aggressive treatment, it seems to be impossible to prevent the development of distant metastasis. Therefore, more research is needed to identify molecular biomarkers that predict the clinical outcome and to develop effective treatment for patients with ACC. (author)

2007-11-01

138

Management of Adenoid Cystic Carcinoma of the Breast: A Rare Cancer Network Study  

International Nuclear Information System (INIS)

Background: Mammary adenoid cystic carcinoma (ACC) is a rare breast cancer. The aim of this retrospective study was to assess prognostic factors and patterns of failure, as well as the role of radiation therapy (RT), in ACC. Methods: Between January 1980 and December 2007, 61 women with breast ACC were treated at participating centers of the Rare Cancer Network. Surgery consisted of lumpectomy in 41 patients and mastectomy in 20 patients. There were 51(84%) stage pN0 and 10 stage cN0 (16%) patients. Postoperative RT was administered to 40 patients (35 after lumpectomy, 5 after mastectomy). Results: With a median follow-up of 79 months (range, 6–285), 5-year overall and disease-free survival rates were 94% (95% confidence interval [CI], 88%–100%) and 82% (95% CI, 71%–93%), respectively. The 5-year locoregional control (LRC) rate was 95% (95% CI, 89%–100%). Axillary lymph node dissection or sentinel node biopsy was performed in 84% of cases. All patients had stage pN0 disease. In univariate analysis, survival was not influenced by the type of surgery or the use of postoperative RT. The 5-year LRC rate was 100% in the mastectomy group versus 93% (95% CI, 83%–100%) in the breast-conserving surgery group, respectively (p = 0.16). For the breast-conserving surgery group, the use of RT significantly correlated with LRC (p = 0.03); the 5-year LRC rates were 95% (95% CI, 86%–100%) for the RT group versus 83% (95% CI, 54%–100%) for the group receiving no RT. No local failures occurred in patients with positive margins, all of whom received postoperative RT. Conclusion: Breast-conserving surgery is the treatment of choice for patients with ACC breast cancer. Axillary lymph node dissection or sentinel node biopsy might not be recommended. Postoperative RT should be proposed in the case of breast-conserving surgery.

2012-04-01

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Synergistic effect of nanosecond pulsed electric field combined with low-dose of pingyangmycin on salivary adenoid cystic carcinoma.  

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Adenoid cystic carcinoma (ACC) is one of the most common malignant neoplasms in salivary glands. To evaluate the therapeutic effects of nanosecond pulsed electric field (nsPEF) combined with pingyangmycin (PYM) on salivary gland adenoid cystic carcinoma (SACC), ACC high metastatic cell line (SACC-LM) and low metastatic cell line (SACC?83) were tested by CCK-8 assay, cell clonogenic assay, flow cytometry and Transwell assay. Extracellular matrix metalloproteinase inducer (EMMPRIN) expression was tested by western blotting to verify the synergistic mechanism of nsPEF and PYM. The results showed that nsPEF inhibited the cell proliferation of both cell lines, and the inhibitory effect was strongly associated with time and electrical field strength. Moreover, PYM combined with nsPEF may enhance the suppression effect significantly, even at a very low dose (0.01 µg/ml). The synergistic effects may contribute to the downregulation of EMMPRIN expression resulting from the application of nsPEF. For SACC, nsPEF combined with chemotherapy agents may be a valuable strategy not only to improve the treatment effect and prognosis, but also to reduce the side-effects of chemotherapy. PMID:24604118

Qi, Wei; Guo, Jinsong; Wu, Shan; Su, Bo; Zhang, Lei; Pan, Jie; Zhang, Jue

2014-05-01

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A retrospective study of 18 cases of adenoid cystic cancer at a tertiary care centre in Delhi  

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Full Text Available Context: Adenoid cystic carcinoma (ACC is a rare neoplasm that usually arises from the salivary, lacrimal, or other exocrine glands. It is characteristically locally infiltrative in nature and has a tendency toward local recurrence, high propensity for perineural invasion, and prolonged clinical course. Aim: To analyze the presentation and natural history of cases of adenoid cystic tumors of salivary glands in our institution; and to compare with the existing literature. Design and Setting: Retrospective study at the Department of Radiotherapy. Materials and Methods: Data on 18 patients of ACC of the salivary glands treated between 2004 and 2008 were reviewed with respect to clinical presentation, stage, and histology. Results: There were 8 cases of major salivary gland tumors (47%, of which 2 were in the submandibular and 6 were involving the parotid. Ten patients (53% had minor salivary gland involvement. Two patients had metastasis at the time of presentation. All patients underwent surgery. Radiotherapy was delivered to 16 patients and chemotherapy to 6 patients (concurrent, n = 3 and adjuvant, n = 3 and no adjuvant therapy was given to 2 patients. All patients were alive at a median follow-up of 3 years. No patient developed local or distant failure during the study duration. Conclusion: ACC has locally aggressive behavior. Radiotherapy adjuvant to surgery improves local control in locally advanced disease. Longer follow-up is mandatory in view of incidence of late metastasis.

Sharma K

2010-01-01

 
 
 
 
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Adenoid cystic carcinoma of the parotid gland: Anastamosis of the facial nerve with the great auricular nerve after radical parotidectomy  

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Full Text Available Adenoid cystic carcinoma of the parotid gland is a rare and slowly growing, but highly malignant tumor. Surgical resection of a malignant parotid tumor should include resection of the facial nerve when the nerve is involved in the tumor. Facial nerve reconstruction is required after nerve resection. A 14 year-old female presented with complaints of painless enlargement of the right parotid gland and facial asymmetry. Physical examination revealed a firm mass in the region of the parotid gland as well as right facial paralysis. Biopsy obtained from the mass showed an adenoid cystic carcinoma of the parotid gland. A radical parotidectomy with a modified radical neck dissection was carried out. Grafting material for the facial reconstruction was harvested from the great auricular nerve. The proximal main trunk and each distal branch of the facial nerve were coapted with the greater auricular nerve. The patient received radiotherapy after surgery and was seen to achieve grade IV facial function one year after surgery. Thus, the great auricular nerve is appropriate grafting material for coaptation of each distal branch of the facial nerve.

Bahadir Osman

2008-01-01

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Reactive Oxygen Species and Autophagy Associated Apoptosis and Limitation of Clonogenic Survival Induced by Zoledronic Acid in Salivary Adenoid Cystic Carcinoma Cell Line SACC-83.  

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Salivary adenoid cystic carcinoma is an epithelial tumor in the head and neck region. Despite its slow growth, patients with salivary adenoid cystic carcinoma exhibit poor long term survival because of a high rate of distant metastasis. Lung and bone are common distant metastasis sites. Zoledronic acid, a third generation bisphosphonate, has been used for tumor-induced osteolysis due to bone metastasis and has direct antitumor activity in several human neoplasms. Here, we observed that zoledronic acid inhibited salivary adenoid cystic carcinoma cell line SACC-83 xenograft tumor growth in nude mice. In vitro, zoledronic acid induced apoptosis and reduced clonogenic survival in SACC-83. Flow cytometry and western blotting indicated that the cell cycle was arrested at G0/G1. Zoledronic acid treatment upregulated reactive oxygen species as well as the autophagy marker protein LC-3B. Reactive oxygen species scavenger N-acetylcysteine and autophagy antagonist 3-methyladenine decreased zoledronic acid-induced apoptosis and increased clonogenic survival. Silencing of the autophagy related gene Beclin-1 also decreased zoledronic acid-induced apoptosis and inhibition of clonogenic formation. In addition, isobolographic analysis revealed synergistic effects on apoptosis when zoledronic acid and paclitaxel/cisplatin were combined. Taken together, our results suggest that zoledronic acid induced apoptosis and reduced clonogenic survival via upregulation of reactive oxygen species and autophagy in the SACC-83 cell line. Thus, zoledronic acid should be considered a promising drug for the treatment of salivary adenoid cystic carcinoma. PMID:24963720

Ge, Xi-Yuan; Yang, Lin-Qian; Jiang, Yang; Yang, Wen-Wen; Fu, Jia; Li, Sheng-Lin

2014-01-01

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Radiographic adenoid evaluation: proposal of an objective parameter / Avaliação radiográfica da tonsila faríngea: proposição de um método de medição objetivo  

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Full Text Available SciELO Brazil | Language: English Abstract in portuguese Objetivo O objetivo deste estudo foi avaliar parâmetros radiográficos atuais destinados à verificação da adenoide e obstrução nasofaríngea e apresentar um método de avaliação alternativo. Materiais e Métodos Crianças (4 a 14 anos) que apresentavam queixas de obstrução nasal e/ou respiração oral f [...] oram submetidas ao exame radiográfico de cavum faríngeo. Cento e vinte registros foram avaliados por parâmetros radiográficos quantitativos, e estes dados foram correlacionados ao exame de videonasofaringoscopia, aqui considerado como padrão ouro, em relação à porcentagem de obstrução coanal. Posteriormente, uma análise de regressão foi realizada com os mesmos parâmetros quantitativos, de modo que um modelo original fosse criado com o objetivo de predição do percentual de obstrução coanal. Resultados Os parâmetros quantitativos atuais demonstraram correlações moderadas, quando não fracas, ao percentual de obstrução. O modelo de regressão desenvolvido (110.119*A/N) demonstrou capacidade satisfatória de “prever” o real percentual de obstrução adenóidea. Conclusão Uma vez que os parâmetros radiográficos atuais apresentam limitações, o modelo original aqui apresentado deve ser considerado como um método de avaliação adenóidea alternativo, a ser utilizado quando a videonasofaringoscopia estiver indisponível. Abstract in english Objective The objective of the present study was to evaluate current radiographic parameters designed to investigate adenoid hypertrophy and nasopharyngeal obstruction, and to present an alternative radiographic assessment method. Materials and Methods In order to do so, children (4 to14 years ol [...] d) who presented with nasal obstruction or oral breathing complaints were submitted to cavum radiographic examination. One hundred and twenty records were evaluated according to quantitative radiographic parameters, and data were correlated with a gold-standard videonasopharyngoscopic study, in relation to the percentage of choanal obstruction. Subsequently, a regression analysis was performed in order to create an original model so the percentage of the choanal obstruction could be predicted. Results The quantitative parameters demonstrated moderate, if not weak correlation with the real percentage of choanal obstruction. The regression model (110.119*A/N) demonstrated a satisfactory ability to “predict” the actual percentage of choanal obstruction. Conclusion Since current adenoid quantitative radiographic parameters present limitations, the model presented by the present study might be considered as an alternative assessment method in cases where videonasopharyngoscopic evaluation is unavailable.

Murilo Fernando Neuppmann, Feres; Juliana Sato, Hermann; Ana Carolina, Sallum; Shirley Shizue Nagata, Pignatari.

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Systemic therapy in the management of metastatic or locally recurrent adenoid cystic carcinoma of the salivary glands: a systematic review.  

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Adenoid cystic carcinomas (ACC) are rare cancers usually arising in the salivary glands. Once metastatic, the natural history can vary; some patients with indolent cancer remain asymptomatic for long periods, whereas others have rapidly progressive disease. Chemotherapy is generally reserved for the palliative treatment of symptomatic locally recurrent or metastatic disease that is not amenable to further surgery or radiation. Prospective trials of chemotherapy in advanced ACC are limited, and the optimum regimen is unclear. The aim of this systematic review is to summarise and rate the quality of trials assessing chemotherapy for treatment of ACC, by use of the European Lung Cancer Working Party scoring system. Endpoints evaluated include tumour response and rates of symptomatic improvement. 34 trials involving 441 patients are included. We give evidence-based recommendations for management of ACC with chemotherapy, along with considerations for the design of future clinical trials in this disease. PMID:21147032

Laurie, Scott A; Ho, Alan L; Fury, Matthew G; Sherman, Eric; Pfister, David G

2011-08-01

145

The effect of 125I seed in comprehensive therapy of the head and neck adenoid cystic carcinoma  

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Adenoid cystic carcinoma (ACC) often occurs in head and neck, many patients are treated with surgical operation combined radiation treatment method in clinic. Surgery combined radiation therapy can achieve good local control, especially for those late-stage cancer undlgo patients who cannot undergo surgical resection. Radiation therapy can alleviate local symptoms, retards the growth of tumor. 125I seed interstitial brachytherapy is an effective treatment method which has the characteristics of minimal damage in normal tissue, accurate positioning in target area and simple operation, and it can be one-time completed. 125I seed can be implanted in tumors through the CT. B ultrasonic and image navigation equipment. Application of 125I seed interstitial brachytherapy treatment in head and neck ACC has achieved good short-term curative effect. Preoperative establishing treatment plan and intraoperative or postoperative quality verification can guarantee the quality of treatment and make 125I seed interstitial brachytherapy work better. (authors)

2011-01-01

146

An unusual presentation of adenoid cystic carcinoma of the minor salivary glands with cranial nerve palsy: a case study  

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Full Text Available Abstract Background Adenoid Cystic Carcinoma (ACC is a rare tumor entity and comprises about 1% of all malignant tumor of the oral and maxillofacial region. It is slow growing but a highly invasive cancer with a high recurrence rate. Intracranial ACC is even more infrequent and could be primary or secondary occurring either by direct invasion, hematogenous spread, or perineural spread. We report the first case of the 5th and 6th nerve palsy due to cavernous sinus invasion by adenoid cystic carcinoma. Case presentation A 49-year-old African American female presented to the emergency room complaining of severe right-sided headache, photophobia, dizziness and nausea, with diplopia. The patient had a 14 year history migraine headaches, hypertension, and mild intermittent asthma. Physical examination revealed right lateral rectus muscle palsy with esotropia. There was numbness in all three divisions of the right trigeminal nerve. Motor and sensory examination of extremities was normal. An MRI of the brain/brain stem was obtained which showed a large mass in the clivus extending to involve the nasopharynx, pterygoid plate, sphenoid and right cavernous sinuses. Biopsy showed an ACC tumor with a cribriform pattern of the minor salivary glands. The patient underwent total gross surgical resection and radiation therapy. Conclusion This is a case of ACC of the minor salivary glands with intracranial invasion. The patient had long history of headaches which changed in character during the past year, and symptoms of acute 5th and 6th cranial nerve involvement. Our unique case demonstrates direct invasion of cavernous sinus and could explain the 5th and 6th cranial nerve involvement as histopathology revealed no perineural invasion.

Morris Pierre A

2007-08-01

147

Adenoid cystic carcinoma of the head and neck treated by surgery with or without postoperative radiation therapy: Prognostic features of recurrence  

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Purpose: This study sought to review a single-institution experience with the management of adenoid cystic carcinoma of the head and neck. Methods and Materials: Between 1960 and 2004, 140 patients with adenoid cystic carcinoma of the head and neck were treated with definitive surgery. Ninety patients (64%) received postoperative radiation to a median dose of 64 Gy (range, 54-71 Gy). Distribution of T stage was: 26% T1, 28% T2, 20% T3, and 26% T4. Seventy-eight patients (56%) had microscopically positive margins. Median follow-up was 66 months (range, 7-267 months). Results: The 5- and 10-year rate estimates of local control were 88% and 77%, respectively. A Cox proportional hazards model identified T4 disease (p = 0.0001), perineural invasion (p = 0.008), omission of postoperative radiation (p = 0.007), and major nerve involvement (p = 0.02) as independent predictors of local recurrence. Radiation dose lower than 60 Gy (p = 0.0004), T4 disease (p 0.005), and major nerve involvement (p = 0.02) were predictors of local recurrence among those treated with surgery and postoperative radiation. The 10-year overall survival and distant metastasis-free survival were 64% and 66%, respectively. Conclusion: Combined-modality therapy with surgery followed by radiation to doses in excess of 60 Gy should be considered the standard of care for adenoid cystic carcinoma of the head and neck

2006-09-01

148

Adenoidal tissue expression of CD23 (Fc?RII: An evaluation with reference to recurrent upper respiratory tract complaints and allergy in children  

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Full Text Available Objective: In this study, CD23, low affinity immunoglobulinE receptor, expression in the adenoid tissue was investigatedimmunohistochemically and evaluated with regardto upper respiratory tract infection complaints and allergy.Methods: This retrospective study was performed by theselection of 100 patients aged 2-13 years who underwentadenoidectomy/adenotonsillectomy and in whom the adenoidtissue pathological studies were reported as “lymphoidhyperplasia and chronic infection” were evaluated.Immunohistochemical evaluation of CD23 expressionwas scored semiquantitatively between 0-3 in the tissuesamples.Results: The mean age in the study group was 70.7months; 46% were female; 30% of patients had adenoidectomyonly. Following the operation, the infection frequencydecreased in 91% of patients, whereas allergysymptoms were unchanged in 84%. CD23 expressionwas found significantly lower in patients who had allergicmanifestations, namely urticaria (p=0.041, drug sensitivity(p=0.035 and pollen allergy (p=0.037.Conclusion: A significantly reduced CD23 expressionwas found in adenoidal tissue in patients with allergicsymptoms. These results can be assessed as an underlyingmechanism for the recurrence of respiratory tractcomplaints in these children, despite adenoidectomy. JClin Exp Invest 2013; 4 (1: 1-7Key words: CD23 expression, adenoid tissue, atopy

Demet Alaygut

2013-03-01

149

Antitumor effects of telomerase-specific replication-selective oncolytic viruses for adenoid cystic carcinoma cell lines.  

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We evaluated the antitumor effect of a telomerase-specific replication-selective adenovirus (Telomelysin, OBP-301) for adenoid cystic carcinoma (ACC) in vitro and in vivo. Adenovirus E1 gene expression was controlled by human telomerase reverse transcription (hTERT). Infection of ACC cells by OBP-301 induced high E1A mRNA expression and subsequent oncolytic cell death in a dose-dependent manner. Using OBP-401 (TelomeScan), a genetically engineered adenovirus that carries the GFP gene under the control of the cytomegalovirus (CMV) promoter at the deleted E3 region of OBP-301, ACC cells expressed bright GFP fluorescence as early as 12 h after OBP-401 infection. The fluorescence intensity gradually increased in a time-dependent manner, followed by rapid cell death due to the cytopathic effect of OBP-401, as evidenced by the floating, highly light-refractive cells using phase-contrast microscopy. Effects of intratumorally injected OBP-401 against established Acc2 xenograft tumors were seen in BALB/c nu/nu mice. The levels of GFP expression following ex vivo infection of OBP-401 may be of value as a positive predictive marker for the outcome of telomerase-specific virotherapy. Our data clearly indicated that telomerase-specific oncolytic adenoviruses have significant therapeutic potential against human ACC in vitro and in vivo. These results suggest that treatment with OBP-301 and OBP-401 may improve the quality of life of oral cancer patients. PMID:24065118

Sato, Daisuke; Kurihara, Yuji; Kondo, Seiji; Shirota, Tatsuo; Urata, Yasuo; Fujiwara, Toshiyoshi; Shintani, Satoru

2013-12-01

150

High Expression of SOX2 Is Associated with Poor Prognosis in Patients with Salivary Gland Adenoid Cystic Carcinoma  

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Full Text Available Sex determining region Y-BOX2 (SOX2, one of the key members of the SOX family, is a transcription factor that is involved in the maintenance of embryonic stem cell pluripotency and in multiple developmental processes. Recent studies have shown that SOX2 is aberrantly expressed in several types of tumors. The present study aimed to investigate the clinicopathological and prognostic significance of SOX2 in adenoid cystic carcinoma (ACC of salivary gland. In this study, the expression of SOX2 in ACC tissues and matched adjacent non-cancerous tissues was measured by immunohistochemistry, western blot, and quantitative polymerase chain reaction. High SOX2 expression occurred in approximately 62.6% of primary ACC. In addition, high expression of SOX2 was significantly associated with T classification (p = 0.003 and distant metastasis (p = 0.002. The 5-year overall survival (OS and disease-free survival (DFS in patients with high SOX2 expression is poorer than those with low SOX2 expression. When adjusted by multivariate analysis, high SOX2 expression, together with distant metastasis, was an independent prognostic factor. The findings of the present study provide evidence that SOX2 represents a potential novel prognostic biomarker for ACC patients.

Wei Dai

2014-05-01

151

EXPRESSION OF MATRIX METALLOPROTEINASE MMP-2 AND ITS TISSUE INHIBITOR TIMP-2 IN INTRAORAL PLEOMORPHIC ADENOMA AND ADENOID CYSTIC CARCINOMA  

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Full Text Available Matrix metalloproteinases (MMPs are proteolytic enzymes that are capable of degrading different substrates within extracellular matrix (ECM, and are believed to be crucial for tumor invasion and metastasis. Tissue inhibitors of MMP (TIMPs can inhibit the action of MMPs The aim of this study was to analyze protein expression of MMP-2 and TIMP-2 in intraoral pleomorphic adenoma (PLA and adenoid cystic carcinoma (ACC. A total of 35 formalin-fixed paraffin-embedded specimens comprising 19 PLA and 16 ACC were utilized in this study. A standard immunohistochemical technique was used to determine the expression levels of MMP-2 and TIMP-2 proteins. Sections were assessed semi quantitatively .Staining was scored as 0 ( 50% positive tumor cells. For statistical analysis, tumors were divided into two groups, low expressors ( 0-1+ and high expressors (2-3+. PLA showed higher TIMP-2 expression than ACC (p<0.05. No significant difference was observed between PLA and ACC regarding MMP-2 expression. MMP-2 and TIMP-2 expressed mainly in the cytoplasm of epithelial/ myoepithelial components of PLA and neoplastic epithelial cells of ACC. Myoepithelial cells may be the primary source of gelatinases in PLA and the down regulation of TIMP-2 expression in ACC might be responsible for metastasis and recurrence. The ratio value of MMP-2/TIMP-2 is valuable parameter to demonstrate the ECM degradation/ deposition imbalance.

Natheer Hashim AL-Rawi

2011-04-01

152

Immunohistochemical clue for the histological overlap of salivary adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma.  

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It remains difficult to distinguish adenoid cystic carcinoma (ACC) from polymorphous low-grade adenocarcinoma (PLGA). Although these neoplasms exhibit nearly similar histologic patterns, their biologic behavior is significantly different. This study was carried out in an attempt to overcome the histological overlap between these tumors using immunohistochemical method for c-kit and galectin-3 proteins on twenty cases of salivary gland tumors including twelve ACC and eight PLGA. Results revealed positive cytoplasmic reactivity for c-kit in 100% of ACC cases and only in 25% of PLGA. On the other hand, galectin-3 expression was observed in 100% of both ACC and PLGA cases. Moreover, solid variant of ACC showed overexpression of both proteins than cribriform and tubular subtypes. Significant positive correlation between the two studied proteins in ACC and PLGA was also observed (p < 0.05). Upon these results, over expression of c-kit and galectin-3 in ACC cases supports the concept of solid variant as a high-grade tumor. Moreover, c-kit may be used as a helpful marker to distinguish ACC from PLGA in cases where the diagnosis can be challenging. PMID:24265903

El-Nagdy, Sherif; Salama, Naglaa M; Mourad, Mohamed I

2013-09-01

153

Three-dimensional collagen scaffold enhances the human adenoid cystic carcinoma cancer stem cell and epithelial-mesenchymal transition properties.  

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Three-dimensional (3D) cell culture may provide the architectures similar to the in vivo natural extracellular matrix condition for in vitro cultured cells. In this work, a 3D collagen scaffold was used to culture the adenoid cystic carcinoma (ACC) cells. The results showed that the 3D scaffold not only induced the diversification of cell morphologies but also increased the cell proliferation. The transcription of matrix metalloproteinase and epithelial-mesenchymal transition were significantly increased in the cells cultured in 3D collagen scaffolds. In addition, the expression of cancer stem cell (CSC) markers of Sox2 and Oct4 were higher than that in 2D cultured cells. The 3D cultured ACC-83 cells showed more resistance to chemotherapeutic drugs. Thus, the 3D collagen scaffold could provide a useful model for CSCs study and anticancer therapeutics research in vitro. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 102B: 772-780, 2014. PMID:24142425

Liu, Li-Jun; Zhang, Jing; Xiao, Zhi-Feng; Dai, Bin; Sun, Mo-Yi; Chen, Lei; Chen, Bing

2014-05-01

154

125I brachytherapy alone for recurrent or locally advanced adenoid cystic carcinoma of the oral and maxillofacial region  

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Background and purpose: This retrospective study was to evaluate the local control and survival of 125I brachytherapy for recurrent and/or locally advanced adenoid cystic carcinoma (ACC) of the oral and maxillofacial region. Patients and methods: A total of 38 patients with recurrent and/or locally advanced ACC of the oral and maxillofacial region received 125I brachytherapy alone from 2001-2010. Twenty-nine were recurrent cases following previous surgery and radiation therapy. The other 9 cases involved primary tumors. Overall, 12 tumors were located in the major salivary glands, 12 in the minor salivary glands, and 14 in the paranasal region, the nasal cavity or the skull base. The prescribed dose was 100-160 Gy. Results: Patients were followed for 12-122 months (median 51 months). The 2-, 5-, and 10-year local tumor control rates were 86.3, 59, and 31.5 %, respectively. The 2-, 5-, and 10-year overall survival rates were 92.1, 65 and 34.1 %, respectively. Tumors > 6 cm had significantly lower local control and survival rates. No severe complications were observed during follow-up. Conclusion: 125I brachytherapy is a feasible and effective modality for the treatment of locally advanced unresectable or recurrent ACC. (orig.)

2013-06-01

155

{sup 125}I brachytherapy alone for recurrent or locally advanced adenoid cystic carcinoma of the oral and maxillofacial region  

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Background and purpose: This retrospective study was to evaluate the local control and survival of {sup 125}I brachytherapy for recurrent and/or locally advanced adenoid cystic carcinoma (ACC) of the oral and maxillofacial region. Patients and methods: A total of 38 patients with recurrent and/or locally advanced ACC of the oral and maxillofacial region received {sup 125}I brachytherapy alone from 2001-2010. Twenty-nine were recurrent cases following previous surgery and radiation therapy. The other 9 cases involved primary tumors. Overall, 12 tumors were located in the major salivary glands, 12 in the minor salivary glands, and 14 in the paranasal region, the nasal cavity or the skull base. The prescribed dose was 100-160 Gy. Results: Patients were followed for 12-122 months (median 51 months). The 2-, 5-, and 10-year local tumor control rates were 86.3, 59, and 31.5 %, respectively. The 2-, 5-, and 10-year overall survival rates were 92.1, 65 and 34.1 %, respectively. Tumors > 6 cm had significantly lower local control and survival rates. No severe complications were observed during follow-up. Conclusion: {sup 125}I brachytherapy is a feasible and effective modality for the treatment of locally advanced unresectable or recurrent ACC. (orig.)

Huang, M.W.; Zheng, L.; Liu, S.M.; Shi, Y.; Zhang, J.; Yu, G.Y.; Zhang, J.G. [Peking Univ. School and Hospital of Stomatology, Beijing (China). Dept. of Oral and Maxillofacial Surgery

2013-06-15

156

Carcinoma adenóide quístico recorrente: Revisão a propósito de um caso clínico / Recurrent adenoid cystic carcinoma: Review based on a case report  

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Full Text Available SciELO Portugal | Language: Portuguese Abstract in portuguese O carcinoma adenóide quístico é uma neoplasia epitelial maligna de origem glandular, ocorrendo nas glândulas mamárias, salivares e raramente no pulmão, onde é responsável por 0,2% dos tumores. Embora raro, é o tumor de “tipo glândula salivar” mais comum ao nível do tracto respiratório. Estes tumores [...] apresentam um crescimento lento e curso clínico prolongado, caracterizando-se pela natureza infiltrativa, com tendência para a recorrência local tardia. Os autores apresentam o caso de uma mulher com carcinoma adenóide quístico do pulmão diagnosticado na sequência de investigação de nódulo do pulmão submetida a ressecção cirúrgica com intuito curativo, cujo follow-up documentou recidiva local tardia 9 anos após a ressecção. O presente caso vem realçar a necessidade de vigilância prolongada, dado o potencial de recidiva local tardia deste tipo de tumor. O artigo revê aspectos clínicos e patológicos do carcinoma adenóide quístico do pulmão e discute opções terapêuticas, nomeadamente de prevenção da recidiva, à luz dos conhecimentos actuais. Abstract in english The adenoid cystic carcinoma is a malignant epithelial glandular type neoplasia, occurring frequently in the salivary and mammary glands, and rarely in the lung, and is responsible for 0.2% of lung tumours. These tumours present a slow growth and prolonged clinical course, and are characterised by t [...] heir infiltrative nature and tendency towards late local recurrence. The authors present a case of a woman with adenoid cystic lung carcinoma diagnosed after investigation of a lung nodule, submitted to surgical resection with curative intention, whose follow -up identified late recurrence, 9 years after surgery. The present case emphasises the need for a prolonged surveillance, due to the potential late recurrence of this kind of tumour. The article reviews clinical and pathological features of lung adenoid cystic carcinoma, as well as therapeutic options, namely for prevention of recurrence.

Nicole, Murinello; M Emília, Vitorino; Cristina, Matos; José Manuel, Correia; Manuela, Lima; Pedro, Baptista; José Sena, Lino; Fernando, Nogueira.

157

Efficacy of sorafenib, a multi-tyrosine kinase inhibitor, in an adenoid cystic carcinoma metastatic to the lung: case report and review of literature  

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Full Text Available Abstract Introduction Treatment for squamous cell carcinoma of the head and neck has significantly improved with the addition of cetuximab, a monoclonal antibody against the epidermal growth factor receptor, to conventional cytotoxic agents. The most significant aspect of this treatment approach is the proof that head and neck cancers are suitable for targeted therapies as has been shown in other malignancies. Unfortunately, there are other rare histologic types of head and neck cancer such as adenocarcinoma and adenoid cystic carcinoma. The latter has traditionally been considered to be chemotherapy resistant and surgical resection with or without adjuvant radiation therapy has been the rule as far as treatment is concerned. The course of adenoid cystic carcinoma ranges from indolent to aggressive; however, most patients succumb to the disease as a result of distant metastases. This clinical scenario poses a challenge to oncologists. Several conventional chemotherapy regimens and novel targeted agents have been tried in this rare histologic subtype without success. Case presentation In this case report, we present a 59-year-old Caucasian female with refractory adenoid cystic carcinoma of the maxilla metastatic to the lung that responded to sorafenib, a novel multi-tyrosine kinase inhibitor, which targets angiogenesis, Raf kinase pathway, platelet-derived growth factor Ret, and c-Kit. Conclusion This case illustrates the possibility that this chemoresistant tumor may need the inhibition or blocking of several oncogenic pathways. Certainly, it is imperative that more studies are done in this special population trying to identify tumorigenesis mechanisms that may be upregulated in this malignancy and could be potential targets for therapeutic development.

Santos Edgardo S

2011-09-01

158

The Role of Radiation Therapy in the Treatment of Adenoid Cystic Carcinoma of the Head and Neck  

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Forty eight patients with adenoid cystic carcinoma(ACC) in the head and beck treated between 1979 and 1990 were reviewed according to treatment modalities and clinical courses. The common site of origin was minor salivary gland (69%), mostly had palate and maxillary sinus. 11 patients received radiation therapy(RT) alone and 37 patients received combined surgery and radiation therapy. The follow-up period of the survivors ranged from 4 to 118 months (median 49.5 months). The 5 year local control rate was 69.3%, 67.3% and 83.9% in RT alone, conservative operation(OP)+RT and radical OP+RT group, respectively(p>0.05). The control of local disease was best achieved with radical OP+RT. In postoperative RT, high dose ({>=}60 Gy) and generous field size (>64cm{sup 2}) yielded a better local control rate. Actuarial overall survival rate was 79.0%, at 5 years and 19.2% at 10 years. Distant metastases (DM) developed in 40% of patients, mostly in the lung. Disease-free(NED) survival rate was 45.8%, at 5 years and significant differences did not exist according to primary sites and treatment options. Survival rate after the onset of DM was 19.5% at 5 years. Occurrence of DM tends to lower survival significantly. In an effort to find the role of RT in the treatment of ACC, our data suggest that a well-planned postoperative RT employing a high dose and generous field size can produce high local control rate and remaining urgent problem of distant metastasis demands more effective chemotherapy for the purpose of improving survival of ACC patients.

Kim, Won Dong; Park, Charn Il; Kim, Kwang Hyun [Seoul National University College of Medicine, Seoul (Korea, Republic of)

1992-06-15

159

The Role of Radiation Therapy in the Treatment of Adenoid Cystic Carcinoma of the Head and Neck  

International Nuclear Information System (INIS)

Forty eight patients with adenoid cystic carcinoma(ACC) in the head and beck treated between 1979 and 1990 were reviewed according to treatment modalities and clinical courses. The common site of origin was minor salivary gland (69%), mostly had palate and maxillary sinus. 11 patients received radiation therapy(RT) alone and 37 patients received combined surgery and radiation therapy. The follow-up period of the survivors ranged from 4 to 118 months (median 49.5 months). The 5 year local control rate was 69.3%, 67.3% and 83.9% in RT alone, conservative operation(OP)+RT and radical OP+RT group, respectively(p>0.05). The control of local disease was best achieved with radical OP+RT. In postoperative RT, high dose (?60 Gy) and generous field size (>64cm2) yielded a better local control rate. Actuarial overall survival rate was 79.0%, at 5 years and 19.2% at 10 years. Distant metastases (DM) developed in 40% of patients, mostly in the lung. Disease-free(NED) survival rate was 45.8%, at 5 years and significant differences did not exist according to primary sites and treatment options. Survival rate after the onset of DM was 19.5% at 5 years. Occurrence of DM tends to lower survival significantly. In an effort to find the role of RT in the treatment of ACC, our data suggest that a well-planned postoperative RT employing a high dose and generous field size can produce high local control rate and remaining urgent problem of distant metastasis demands more effective chemotherapy for the purpose of improving survival of ACC patients

1992-06-01

160

Treatment results and prognostic analysis of 54 patients with adenoid cystic carcinoma originated from the major salivary glands  

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Objective: Adenoid cystic carcinoma (ACC), a rare malignancy in head and neck region, is predominately found in the salivary glands. Our study is to retrospectively analyze the treatment outcomes and prognostic factors of ACC originated from the major salivary glands. Methods: A total of 54 patients diagnosed as ACC were treated in our institution, including 24 cases originated from the parotid gland and 30 from the submandibular or sublingual gland. According to the records, 26 patients received surgery alone and 28 were treated with surgery followed by radiotherapy with a median dose of 58 Gy (range, 50 -65 Gy). Results: The Follow-up rate was 94%, and 15 patients from postoperative radiotherapy group and 20 from surgery alone group were followed up more then 5 years. The 5-year overall survival rate, local-regional control rate, distant metastasis rate, and disease-free survival rate were 97%, 71%, 13% and 69%, respectively. Lung metastasis, occurred in 7 patients, was the most common distant failure. Fifteen recurrences were observed, including 13 in surgery alone group and 2 in postoperative radiotherapy group. The 5-year local-regional control and disease-free survival rates were 90% and 85% for patients treated with postoperative radiotherapy, 54% and 55% for those treated with surgery alone. Univariate and multivariate analyses showed that postoperative radiotherapy was the only prognostic factor of local-regional control and survival rates. Other parameters such as nerve involvement did not significantly influence the treatment results. Conclusions: Postoperative radiotherapy can improve the prognosis of ACC originate from the major salivary glands compared with surgery alone. Distant metastasis is an obstacle in curing the disease, which indicates the value of systemic treatment. (authors)

2010-03-01

 
 
 
 
161

Therapeutic strategies for adenoid cystic carcinoma of the nasal and paranasal sinus from the long-term treatment results  

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This article presents long-term treatment results by analyzing 24 cases with adenoid cystic carcinoma (ACC) of the nasal and paranasal sinus treated from 1975 to 1995 at Akita University Hospital and Chiba University Hospital. The basic strategies for treatment for ACC of the nasal and paranasal sinuses are en bloc tumor resection, followed by primary reconstruction of the maxilla. Preoperative and postoperative radiation were combined. Cumulative 5-year and 10-year survival rates were 70.6% and 47.1% for maxillary sinus tumors, respectively. Cumulative 5-year and 10-year survival rates for nasal tumors were 100% and 75.0%, and those for sphenoid sinus tumors were 50.0% and 0%, respectively. The patient with ethomoid sinus who needed skull base surgery is alive at 8.1 years after therapy. Treatment results closely correlated with tumor extension. Cumulative 5-year survival rates for T2, T3 and, T4 patients with maxillary sinus tumors were 85.7%, 71.4%, and 33.3%, respectively. And cumulative 10-year survival rates for T2, T3, and T4 were 71.4%, 42.9%, and 0%, respectively. The histopathological effects of preoperative radiation were Shimosato II a in 6 out of 10 patients, II b in 2, and III in 2, respectively. Only fast neutron therapy reached Shimosato III. Two of the patients with Shimosato II a died of distant metastasis. The above data suggests that, although radiation therapy alone cannot cure tumors, preoperative full-dose radiation may prevent the development of distant metastasis if it can achieve histopathological effects of a higher classification than Shimosato II b. Because chemotherapy and radiation is not very effective on ACC, the role of skull base surgeries for nasal-paranasal sinus malignancies that invade the skull base is valuable, particularly in cases having a relatively small mass in the ethmoid sinus. (author)

Terada, Nobuhisa; Numata, Tsutomu; Mutoh, Hiroyuki; Ueki, Yuji; Gorai, Shigeki; Konno, Akiyoshi [Chiba Univ. (Japan). School of Medicine

2001-03-01

162

Carcinoma adenoideo quístico de la próstata: Presentación de 2 casos / Cystic adenoid carcinoma of the prostate: Report of two cases  

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Full Text Available SciELO Spain | Language: Spanish Abstract in spanish Objetivo: Presentamos dos casos con diagnóstico histológico de carcinoma adenoideo quístico de la próstata, tumor de presentación extremadamente raro. Métodos: Evaluamos a dos pacientes con edad de presentación, manifestación clínica, diagnóstico, tratamiento y evolución distintos. Resultados: La ed [...] ad varia de 41 y 59 años, con dolor perineal y sintomatología urinaria baja, tacto rectal masa tumoral redondeada y dura o normal respectivamente. El antígeno prostático específico y la fosfatasa ácida prostática son normales, el ultrasonido transrectal puede ser normal o aportar con el hallazgo de nódulo hipoecoico, se realizó tratamiento quirúrgico con prostatectomía radical e inmunoterapia adyuvante en el primero que a los 6 años evoluciona a metastasis pulmonar y muere, el otro cistoprostatectomía radical con derivación urinaria ortotópica con buena evolución a los dos años. Conclusiones: La clínica es inespecífica, generalmente el diagnóstico es mediante resección transuretral o biopsia transrectal ante la sospecha por tacto rectal o ultrasonido, es inmunoreactivo para p53 y citoqueratinas 7 y 34 beta E12 y el tratamiento de elección es la cistoprostatectomía radical debido a que es una neoplasia potencialmente agresiva y puede añadirse tratamiento adyuvante. Abstract in english Objective: We report two cases with the pathologic diagnosis of cystic adenoid carcinoma of the prostate, an extremely rare tumor. Methods: We evaluate two patients with different age, clinical presentation, diagnosis, treatment and outcome. Results: The ages were 41 and 59, the symptoms perineal pa [...] in and lower urinary tract symptoms, on digital rectal examination a round hard tumor mass and normal exam, respectively. PSA and prostatic acid phosphatase were normal; Transrectal ultrasound may be normal or find a hypoechoic node. The first patient underwent radical prostatectomy and adjuvant immunotherapy; six years after surgery he developed lung metastasis and died. The second patient underwent radical cystoprostatectomy with orthotopic urinary diversion with good outcome after two years of follow-up. Conclusions: The clinical presentation is non specific, with the diagnosis generally obtained by transurethral resection or transrectal biopsy after the suspicion of an abnormal digital rectal examination or ultrasound. The tumor is immunoreactive to p53 and citokeratins 7 and 34 Beta E12, and the treatment of choice is radical cystoprostatectomy because it is a potentially aggressive neoplasia; adjuvant treatment may be added.

Isis E., Pedro Silva; Vicente, Osorio Acosta; F. Albaro, Farfán Chávez.

163

The effect of proteoglycans inhibited by RNA interference on metastatic characters of human salivary adenoid cystic carcinoma  

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Full Text Available Abstract Background Salivary adenoid cystic carcinoma (SACC is one of the most common malignancies of salivary gland. Recurrence or/and early metastasis is its biological properties. In SACC, neoplastic myoepithelial cells secrete proteoglycans unconventionally full of the cribriform or tubular and glandular structures of SACC. Literatures have demonstrated that extracellular matrix provided an essential microenvironment for the biological behavior of SACC. However, there is rare study of the effect of proteoglycans on the potential metastasis of SACC. In this study, human xylosyltransferase-I (XTLY-I gene, which catalyzes the rate-limited step of proteoglycans biosynthesis, was knocked down by RNA interference (RNAi to inhibit the proteoglycans biosynthesis in SACC cell line with high tendency of lung metastasis (SACC-M. The impact of down-regulated proteoglycans on the metastasis characters of SACC-M cells was analyzed and discussed. This research could provide a new idea for the clinical treatment of SACC. Methods The eukaryotic expression vector of short hairpin RNA (shRNA targeting XTLY-I gene was constructed and transfected into SACC-M cells. A stably transfectant cell line named SACC-M-WJ4 was isolated. The XTLY-I expression was measured by real-time PCR and Western blot; the reduction of proteoglycans was measured. The invasion and metastasis of SACC-M-WJ4 cells were detected; the effect of down-regulated proteoglycans on the potential lung metastasis of nude mice was observed, respectively. Results The shRNA plasmid targeting XTLY-I gene showed powerful efficiency of RNAi. The mRNA level of target gene decreased by 86.81%, the protein level was decreased by 80.10%, respectively. The silence of XTLY-I gene resulted in the reduction of proteoglycans significantly in SACC-M-WJ4 cells. The inhibitory rate of proteoglycans was 58.17% (24 h, 66.06% (48 h, 57.91% (72 h, 59.36% (96 h, and 55.65% (120 h, respectively. The reduction of proteoglycans suppressed the adhesion, invasion and metastasis properties of SACC-M cells, and decreased the lung metastasis of SACC-M cells markedly either. Conclusion The data suggested that the silence of XTLY-I gene in SACC-M cells could suppress proteoglycans biosynthesis and secretion significantly. The reduction of proteoglycans inhibited cell adhesion, invasion and metastasis of SACC-M cells. There is a close relationship between proteoglycans and the biological behavior of SACC.

Li Hexiang

2009-12-01

164

Mechanisms of apple polyphenols-induced proliferation inhibiting and apoptosis in a metastatic oral adenoid cystic carcinoma cell line.  

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Adenoid cystic carcinoma (ACC) is characterized by intensive local invasion and high incidence of distant metastases. Conventional chemotherapy for ACC produces a poor result. We aimed to evaluate the effect of apple polyphenols (APs), a novel nutraceutical agent, on the proliferation and apoptosis levels in a metastatic oral ACC cell line. A metastatic ACC (ACC-M) cell line and control cells (MRC-5 cells derived from normal lung tissue) were treated with APs at different concentrations. MTT assay was used to determine the in vitro cytotoxicity. The cell cycle distribution and apoptosis levels were measured by flow cytometry. To evaluate the mechanism of APs, vascular endothelial growth factor receptor-2 (VEGFR-2) and caspase-3 messenger ribonucleic acid (mRNA) and protein levels were evaluated by reverse transcription-polymerase chain reaction and Western blots, respectively. After cells were cultured for 24 hours or 48 hours, the critical concentration of cytotoxicity of APs in MRC-5 cells was found to be 250 ?g/mL. In contrast, in the concentration range of 100-250 ?g/mL, the cytotoxicity of APs in ACC-M cells was time- and dose-dependent: ACC-M cell proliferation declined at 100 ?g/mL when cultured for 48 hours, whereas growth was not inhibited at the concentrations of APs below 200 ?g/mL when cultured for 24 hours. In selected time and dose patterns (ACC-M cells cultured at the concentrations of 150 and 250 ?g/mL for 48 hours), the flow cytometry performance showed that apoptosis and necrosis occurred in APs-treated ACC-M cells. Also, in these patterns, VEGFR-2 mRNA and protein levels decreased whereas the levels of caspase-3 increased. In summary, APs could inhibit proliferation and induce apoptosis in ACC-M cells in vitro. These effects may be related to the downregulation of VEGFR-2 expression and the activation of caspase-3 expression. PMID:23639509

Zheng, Chao-Qun; Qiao, Bin; Wang, Miao; Tao, Qian

2013-05-01

165

Carcinoma adenoideo quístico del dorso de la lengua: Presentación de un caso clínico / Adenoid cystic carcinoma of the dorsum of the tongue: Presentation of a case  

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Full Text Available SciELO Spain | Language: Spanish Abstract in spanish El carcinoma adenoideo quístico es la neoplasia maligna de glándulas salivales menores más frecuente (76.5%), se caracteriza clínicamente por ser de crecimiento lento, la localización más frecuente es el paladar duro. Histopatológicamente presenta tres patrones, cribiforme, tubular y sólido; el tipo [...] sólido esta relacionado con un pobre pronóstico a diferencia del tipo cribiforme que tiene un mejor pronóstico. El tratamiento de elección es la excisión quirúrgica con márgenes amplios y cuando existe metástasis a nódulos linfáticos está indicada la radioterapia posquirúrgica. Se presenta el caso clínico de un hombre de 19 años de edad con recidiva de lesión en dorso de lengua y diagnóstico previo de adenoma monomorfo. En la segunda biopsia se diagnostica como carcinoma adenoideo quístico, por lo que probablemente hubo un error en el diagnóstico original, se decide usar inmunohistoquímica: CALP, CEA, Antígeno Epitelial de Membrana, Proteína Ácido Fibrilar Glial, Ki67, las cuales se observaron positivas en diferentes intensidades, lo que corroboró el diagnóstico de carcinoma adenoideo quístico. El paciente presentó recidiva después de 2 años. Abstract in english Adenoid cystic carcinoma is the most frequent malignant neoplasm of minor salivary glands (76.5%); it is clinically characterized by slow growth, and its most frequent localization is the hard palate. Histopathologically it presents three patterns, cribriform, tubular and solid; the solid type is re [...] lated to a poor prognostic contrary to the cribriform type, which has a better prognosis. Surgical excision with wide margins is the treatment of choice, if it metastasizes to lymph nodules, post surgical radiotherapy is recommended. A 19 year-old man presented a recurrent lesion on the dorsum of the tongue previously diagnosed as monomorphic adenoma. In a second biopsy it was diagnosed as adenoid cystic carcinoma. The following immunohistochemical studies were ordered: CALP, CEA, Epithelial Membrane Antigen, Glial Fibrilar Acid Protein, Ki67; all of these studies were positive and with different intensities, corroborating the diagnosis of adenoid cystic carcinoma. The patient had a recurrence after 2 years.

Carrasco Ortiz, Dolores; Aldape Barrios, Beatriz.

166

Estudo clínico, randomizado, duplo-cego, em crianças com adenóide obstrutiva, submetidas a tratamento homeopático / Prospective, randomized, double-blind clinical trial about efficacy of homeopathic treatment in children with obstructive adenoid  

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Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese OBJETIVO: Avaliar a eficácia e segurança do tratamento homeopático em crianças com adenóide obstrutiva, com indicação cirúrgica. FORMA DE ESTUDO: Clínico prospectivo. Material e método: Estudo prospectivo, duplo-cego, randomizado, em que foram incluídas 40 crianças com idade variando de 3 a 7 anos, [...] 20 crianças foram tratadas com medicação homeopática individualizada (Simillimum), baseada no princípio da similitude e 20 crianças receberam placebo. Todas as crianças do grupo medicação homeopática foram medicadas diariamente com Agraphis nutans 6 CH, Thuya 6 CH e Adenóide 21CH; e as do grupo placebo receberam diariamente medicamentos sem o princípio ativo. A duração do estudo de cada paciente foi de 4 meses. A avaliação dos resultados foi clínica, por meio de questionário padrão, de exame otorrinolaringológico e nasofaringoscopia direta com fibroscópio flexível, no primeiro e no último dia de tratamento. Utilizou-se como critério de inclusão a adenóide que ocupou mais do que 70% da luz coanal. RESULTADOS: Das 20 crianças tratadas com medicamento homeopático, 13 não apresentaram alteração no tamanho da adenóide nos exames nasofaringoscópicos e 7 tiveram diminuição da adenóide; das 20 crianças que receberam placebo por 4 meses, 11 não apresentaram alterações no tamanho da adenóide, 4 tiveram diminuição da adenóide e 5 crianças tiveram aumento. Não houve diferença estatística significante entre os grupos (P= 0,069). Na avaliação clínica da evolução dos pacientes, dos 20 pacientes tratados com medicamento homeopático, 17 se mantiveram inalterados, com respiração oral e ronco, um paciente melhorou, ficando sem ronco e dois foram curados, isto é, a respiração alterou-se de oral para nasal e sem ronco. Dos 20 pacientes tratados com placebo, 17 pacientes se mantiveram inalterados, um paciente melhorou do ronco e dois foram curados, não tendo havido diferença estatística significante entre os grupos (P>0,999). CONCLUSÕES: O tratamento homeopático não foi eficaz nas crianças com adenóide obstrutiva, mantendo-se a indicação cirúrgica em 85% dos pacientes. O medicamento homeopático não provocou eventos adversos nas crianças. Abstract in english AIM: the efficacy and security of homeopathic treatment was investigated on children with obstructive adenoid justifying an operation. STUDY DESIGN: Clinical prospective. MATERIAL AND METHOD: In a prospective, randomized, double-blind clinical trial included 40 children between the ages of 3 to 7 ye [...] ars old, 20 children were treated with homeopathic medication, based in the principle of similarity (Simillimum), and 20 children with placebo. All the children of the homeopathic group/ adenoid, were treated daily with Agraphis nutans 6 CH, Thuya 6 CH and Adenoid 21CH, and the patients of the placebo group received daily placebo medication. The duration of the study of each children was 4 months. The evaluation of the results was clinical, and it was made by questionnaire standard, clinical examination and direct flexible fiberoptic nasopharyngoscopy, in the first and last day of treatment. The criterion of selection was the adenoid that occuped more than 70% of the coanal space. RESULTS: From the group of 20 children treated with homeopathic treatment, 13 did not show any change on the size of adenoid after nasopharyngoscopy, and 7 children had their adenoid decreased; from another group of 20 children that have treated with placebo for 4 months, 11 did not show any change on the size of their adenoid, 4 had their adenoid decreased and 5 had their adenoid increased. The statistical analysis showed a not significant difference (P= 0,069). The clinical evaluation of the patients showed that from the group of 20 patients treated with homeopathy, 17 kept unchanging, with oral breathing and snoring, one patient got better, eliminating the snoring and two were cured, which mean that their oral breathing turned to nasal breathing w

Furuta, Sergio E.; Weckx, Luc L.M.; Figueiredo, Claudia R..

167

Estudo clínico, randomizado, duplo-cego, em crianças com adenóide obstrutiva, submetidas a tratamento homeopático Prospective, randomized, double-blind clinical trial about efficacy of homeopathic treatment in children with obstructive adenoid  

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Full Text Available OBJETIVO: Avaliar a eficácia e segurança do tratamento homeopático em crianças com adenóide obstrutiva, com indicação cirúrgica. FORMA DE ESTUDO: Clínico prospectivo. Material e método: Estudo prospectivo, duplo-cego, randomizado, em que foram incluídas 40 crianças com idade variando de 3 a 7 anos, 20 crianças foram tratadas com medicação homeopática individualizada (Simillimum, baseada no princípio da similitude e 20 crianças receberam placebo. Todas as crianças do grupo medicação homeopática foram medicadas diariamente com Agraphis nutans 6 CH, Thuya 6 CH e Adenóide 21CH; e as do grupo placebo receberam diariamente medicamentos sem o princípio ativo. A duração do estudo de cada paciente foi de 4 meses. A avaliação dos resultados foi clínica, por meio de questionário padrão, de exame otorrinolaringológico e nasofaringoscopia direta com fibroscópio flexível, no primeiro e no último dia de tratamento. Utilizou-se como critério de inclusão a adenóide que ocupou mais do que 70% da luz coanal. RESULTADOS: Das 20 crianças tratadas com medicamento homeopático, 13 não apresentaram alteração no tamanho da adenóide nos exames nasofaringoscópicos e 7 tiveram diminuição da adenóide; das 20 crianças que receberam placebo por 4 meses, 11 não apresentaram alterações no tamanho da adenóide, 4 tiveram diminuição da adenóide e 5 crianças tiveram aumento. Não houve diferença estatística significante entre os grupos (P= 0,069. Na avaliação clínica da evolução dos pacientes, dos 20 pacientes tratados com medicamento homeopático, 17 se mantiveram inalterados, com respiração oral e ronco, um paciente melhorou, ficando sem ronco e dois foram curados, isto é, a respiração alterou-se de oral para nasal e sem ronco. Dos 20 pacientes tratados com placebo, 17 pacientes se mantiveram inalterados, um paciente melhorou do ronco e dois foram curados, não tendo havido diferença estatística significante entre os grupos (P>0,999. CONCLUSÕES: O tratamento homeopático não foi eficaz nas crianças com adenóide obstrutiva, mantendo-se a indicação cirúrgica em 85% dos pacientes. O medicamento homeopático não provocou eventos adversos nas crianças.AIM: the efficacy and security of homeopathic treatment was investigated on children with obstructive adenoid justifying an operation. STUDY DESIGN: Clinical prospective. MATERIAL AND METHOD: In a prospective, randomized, double-blind clinical trial included 40 children between the ages of 3 to 7 years old, 20 children were treated with homeopathic medication, based in the principle of similarity (Simillimum, and 20 children with placebo. All the children of the homeopathic group/ adenoid, were treated daily with Agraphis nutans 6 CH, Thuya 6 CH and Adenoid 21CH, and the patients of the placebo group received daily placebo medication. The duration of the study of each children was 4 months. The evaluation of the results was clinical, and it was made by questionnaire standard, clinical examination and direct flexible fiberoptic nasopharyngoscopy, in the first and last day of treatment. The criterion of selection was the adenoid that occuped more than 70% of the coanal space. RESULTS: From the group of 20 children treated with homeopathic treatment, 13 did not show any change on the size of adenoid after nasopharyngoscopy, and 7 children had their adenoid decreased; from another group of 20 children that have treated with placebo for 4 months, 11 did not show any change on the size of their adenoid, 4 had their adenoid decreased and 5 had their adenoid increased. The statistical analysis showed a not significant difference (P= 0,069. The clinical evaluation of the patients showed that from the group of 20 patients treated with homeopathy, 17 kept unchanging, with oral breathing and snoring, one patient got better, eliminating the snoring and two were cured, which mean that their oral breathing turned to nasal breathing without snoring. From the group of 20 patients treated with placebo, 17 kept unchanging, one elimina

Sergio E. Furuta

2003-06-01

168

An unusual case of exclusive liver metastases from adenoid cystic carcinoma of the submandibular gland: a role for surgery? Report of a case.  

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Adenoid cystic carcinoma (ACC) is a relatively rare tumor of the salivary glands, accounting for approximately 5%-10% of all salivary gland tumors. An important feature of ACCs is the long clinical course with a high rate of distant metastases, with an incidence of more than 40% for ACC of submandibular glands. The preferential sites of metastases are the lung and bone, followed by the brain and liver. Most liver metastases are derived from nonparotid ACCs, and the presentation is often related to local recurrence or metastases to other organs. We herein report the case of a patient with liver metastases treated by a hepatectomy, which occurred 18 months after the primary resection of an ACC of the submandibular gland. We furthermore review the literature concerning the management of these tumors. PMID:21431502

Balducci, Genoveffa; Sagnotta, Andrea; Muroni, Mirko; Cacchi, Claudio; D'Amato, Alberto

2011-04-01

169

Primary adenoid cystic carcinoma of trachea presenting as midline neck swelling and mimicking thyroid tumor: A case report and review of literature  

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Full Text Available We report an extremely rare case of primary adenoid cystic carcinoma (ACC trachea presenting as midline swelling neck and mimicking thyroid tumor. A 44-year-old female presented with painless midline swelling neck without any respiratory complaints, hoarseness of voice or dysphagia etc. Fine needle aspiration cytology (FNAC from swelling reveal features of papillary carcinoma thyroid. Subsequently the operative findings, bronchoscopy and histological diagnosis of excised mass, along with review of FNAC, revealed features of ACC of trachea with exra tracheal extension anteriorly into the soft tissue neck, without actual invasion of the thyroid gland. The world literature on extension of an ACC arising in the laryngotracheal complex to thyroid or soft tissue neck and clinical manifestation as a thyroid nodule or mass is reviewed. The cytological differential diagnosis of ACC and CT findings are also briefly discussed.

Nuwal Paras

2010-01-01

170

Concurrent occurrence of adenoid cystic carcinoma of the salivary glands with small cell carcinoma of the liver: A rare case report.  

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Adenoid cystic carcinoma (ACC) is a clinically deceptive and histologically specific malignancy of salivary gland origin. It is the most common minor salivary gland malignancy. Small cell carcinoma (SCC) is a type of undifferentiated malignant neuroendocrine tumor reported rarely in the liver. Though there are many reported cases of SCC involving liver and ACC of minor salivary glands, the review of literature does not show any reports of concomitant occurrence of these two tumors. We describe a rare case of ACC of the oral cavity and its coexistence with a SCC involving liver, identified and confirmed by histological, and immunohistochemical observations. To our knowledge, this is the first reported case of an ACC of the oral cavity and SCC of liver occurring concomitantly in the same patient. PMID:24250095

Premkumar, Jeyanthi; Karthik, S; Sathyakumar, M; Martin, Yakob

2013-05-01

171

In vitro angiogenesis and expression of nuclear factor ?B and VEGF in high and low metastasis cell lines of salivary gland Adenoid Cystic Carcinoma  

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Full Text Available Abstract Background Adenoid cystic carcinoma is a high malignant carcinoma characterized by intensive local invasion and high incidence of distant metastasis. Although many reports have demonstrated that angiogenesis has played an important role in tumor metastasis, the relationship between metastasis characters and angiogenesis ability in high and low metastasis cell lines of Adenoid cystic carcinoma has rarely been reported. The present study aimed to compare the angiogenesis ability of ACC-M (high metastasis and ACC-2 (low metastasis cell lines in vitro. Furthermore, the activity of nuclear factor ?appa B and the expression of vascular endothelial growth factor (VEGF in ACC-2 and ACC-M were also detected. Methods Electrophoretic mobility shift assay was used to detect nuclear factor ?appa B activity. Semi-quantitative RT-PCR was used to quantify the mRNA level of VEGF. Immuofluorescence double staining and semi-quantitative confocal laser scanning analysis was carried out to detect nuclear factor ?appa B nuclear localization and staining intensity of VEGF. The angiogenesis ability of ACC-M and ACC-2 was compared by an in vitro three-dimensional angiogenic model assay. The vector transfection assay was performed to transfect the PCMV-I?B?M vector into ACCs cell lines expressing the phosphorylation defective I?B?M. Results Nuclear factor ?appa B activity and the rate of nuclear factor ?appa B nuclear localization in ACC-M was significantly higher than that in ACC-2. Moreover, ACC-M exhibited higher mRNA and protein levels of vascular endothelial growth factor than ACC-2. VEGF mRNA expression was effectively decreased by inhibition of nuclear factor ?appa B activity. Furthermore, ACC-M could remarkably stimulate the migration and tube formation of endothelial cells and induce The umbilical vein endothelial cells sprouting into the gel matrix. Conclusion These results implicated that ACCs cells with higher metastasis feature might present greater angiogenesis ability.

Peng Bin

2007-06-01

172

Tonsils and Adenoids  

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... preoperative and postoperative care and answer your questions. After surgery There are several postoperative problems that may arise. ... bleeding from the mouth or nose may occur after surgery. If the patient has any bleeding, your surgeon ...

173

Estudo comparativo radiológico e nasofibroscópico do volume adenoideano em crianças respiradoras orais Comparison between radiological and nasopharyngolaryngoscopic assessment of adenoid tissue volume in mouth breathing children  

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Full Text Available A tonsila faríngea ou adenóides é a extensão superior do anel linfático de Waldeyer e está localizada na porção alta da cavidade nasofaríngea, próxima à tuba auditiva e à coana. Ela desempenha um papel relevante nas otites médias recorrentes e freqüentemente sua hipertrofia é responsável pela obstrução das vias aéreas superiores. A tonsilectomia é um tratamento comumente realizado para doenças crônicas das tonsilas e ainda é o procedimento cirúrgico mais freqüente e mais antigo realizado em crianças e adultos jovens. Os critérios para a realização da tonsilectomia, o efeito da mesma na integridade imunológica do paciente e seus riscos inerentes à cirurgia são muito discutíveis e controversos em todo o mundo. Estudos de imagem utilizando-se o raio-X do cavo é um método simples, fácil e confortável para avaliar o tamanho das adenóides e o grau de obstrução das vias aéreas superiores. Um estudo nasofibroscópico da nasofaringe pode fornecer uma informação melhor sobre essa região, tendo em vista que ele mostra todas as estruturas presentes na nasofaringe e o grau de obstrução das vias aéreas superiores de forma dinâmica. FORMA DE ESTUDO: Clínico não randomizado. MATERIAL E MÉTODO: Este estudo comparou o grau de hipertrofia e de obstrução das vias aéreas superiores, usando os dois métodos acima, em crianças de 3 a 10 anos de idade, constatando que a nasofibroscopia flexível é um método diagnóstico excepcionalmente mais fidedigno do que o raio-x do cavo, na avaliação volumétrica da adenóide.The pharyngeal tonsil (adenoid constitutes the upper portion of the Waldeyer's ring and is located at the top of the nasopharynx, next to the auditory tube and choana. It plays an important role in recurrent otitis of the middle ear and many times its enlargement is responsible for upper airway obstruction. Tonsillectomy is often the treatment of choice for tonsillar diseases. So far, it is the most frequent and one of the oldest surgical procedures performed in children and young adults. The criteria for tonsillectomy, its effect on patient's immunological integrity and the surgical risks are widely controversial. Image study using paranasal sinuses x-ray is a very simple, easy and comfortable method to evaluate the sizes of adenoids and the grade of upper airway obstruction. Cohen et al. supported that paranasal sinuses x-ray is the best way to determine pharyngeal tonsil hypertrophy. On the other hand, nasopharyngolaryngoscopy can provide more accurate data on the nasopharynx, as it can dynamically reveal its structures and the obstruction status of the upper airway. This study compared the grade of adenoid hypertrophy, as well as upper airway obstruction, using the above-mentioned approaches in children ranging from 3 to 10 years old. The study came to the conclusion that nasopharyngolaryngoscopy is a much more accurate diagnostic procedure than radiological evaluation of the nasopharynx.

Edmir Américo Lourenço

2005-02-01

174

Estudo comparativo radiológico e nasofibroscópico do volume adenoideano em crianças respiradoras orais / Comparison between radiological and nasopharyngolaryngoscopic assessment of adenoid tissue volume in mouth breathing children  

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Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese A tonsila faríngea ou adenóides é a extensão superior do anel linfático de Waldeyer e está localizada na porção alta da cavidade nasofaríngea, próxima à tuba auditiva e à coana. Ela desempenha um papel relevante nas otites médias recorrentes e freqüentemente sua hipertrofia é responsável pela obstru [...] ção das vias aéreas superiores. A tonsilectomia é um tratamento comumente realizado para doenças crônicas das tonsilas e ainda é o procedimento cirúrgico mais freqüente e mais antigo realizado em crianças e adultos jovens. Os critérios para a realização da tonsilectomia, o efeito da mesma na integridade imunológica do paciente e seus riscos inerentes à cirurgia são muito discutíveis e controversos em todo o mundo. Estudos de imagem utilizando-se o raio-X do cavo é um método simples, fácil e confortável para avaliar o tamanho das adenóides e o grau de obstrução das vias aéreas superiores. Um estudo nasofibroscópico da nasofaringe pode fornecer uma informação melhor sobre essa região, tendo em vista que ele mostra todas as estruturas presentes na nasofaringe e o grau de obstrução das vias aéreas superiores de forma dinâmica. FORMA DE ESTUDO: Clínico não randomizado. MATERIAL E MÉTODO: Este estudo comparou o grau de hipertrofia e de obstrução das vias aéreas superiores, usando os dois métodos acima, em crianças de 3 a 10 anos de idade, constatando que a nasofibroscopia flexível é um método diagnóstico excepcionalmente mais fidedigno do que o raio-x do cavo, na avaliação volumétrica da adenóide. Abstract in english The pharyngeal tonsil (adenoid) constitutes the upper portion of the Waldeyer's ring and is located at the top of the nasopharynx, next to the auditory tube and choana. It plays an important role in recurrent otitis of the middle ear and many times its enlargement is responsible for upper airway obs [...] truction. Tonsillectomy is often the treatment of choice for tonsillar diseases. So far, it is the most frequent and one of the oldest surgical procedures performed in children and young adults. The criteria for tonsillectomy, its effect on patient's immunological integrity and the surgical risks are widely controversial. Image study using paranasal sinuses x-ray is a very simple, easy and comfortable method to evaluate the sizes of adenoids and the grade of upper airway obstruction. Cohen et al. supported that paranasal sinuses x-ray is the best way to determine pharyngeal tonsil hypertrophy. On the other hand, nasopharyngolaryngoscopy can provide more accurate data on the nasopharynx, as it can dynamically reveal its structures and the obstruction status of the upper airway. This study compared the grade of adenoid hypertrophy, as well as upper airway obstruction, using the above-mentioned approaches in children ranging from 3 to 10 years old. The study came to the conclusion that nasopharyngolaryngoscopy is a much more accurate diagnostic procedure than radiological evaluation of the nasopharynx.

Lourenço, Edmir Américo; Lopes, Karen de Carvalho; Pontes Jr., Álvaro; Oliveira, Marcelo Henrique de; Umemura, Adriana; Vargas, Ana Laura.

175

The influence of positive margins and nerve invasion in adenoid cystic carcinoma of the head and neck treated with surgery and radiation  

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Purpose: Surgery is the primary treatment for adenoid cystic carcinomas arising from major and minor salivary glands of the head and neck. However, local recurrence is frequent because of the infiltrative growth pattern and perineural spread associated with these tumors. At UTMDACC, we have had a long-standing policy of using postoperative radiotherapy to reduce the risk of local recurrence and to avoid the need for radical surgery; this 30-year retrospective study analyzes the results of this combined modality approach. Methods and Materials: Between 1962 and 1991, 198 patients ages 13-82 years, with adenoid cystic carcinomas of the head and neck, received postoperative radiotherapy for known or suspected microscopic residual disease following surgery. Distribution of primary sites was: parotid: 30 patients; submandibular/sublingual: 41 patients; lacrimal: 5 patients; and minor salivary glands: 122 patients. Eighty-three patients (42%) had microscopic positive margins and an additional 55 (28%) had close (?5 mm) or uncertain margins. One hundred thirty-six patients (69%) had perineural spread with invasion of a major (named) nerve in 55 patients (28%). Using radiation techniques appropriate to the primary site, a median dose of 60 Gy (range 50-69 Gy) was delivered to the tumor bed. Follow-up ranged from 5-341 months (median, 93 months). All surviving patients had a minimum of 2 years follow-up. Results: Twenty-three patients (12%) had local recurrences with 5-, 10-, and 15-year actuarial local control rates of 95%, 86%, and 79%, respectively. Fifteen of the 83 patients (18%) with positive margins developed local recurrences, compared to 5 of 55 patients (9%) with close or uncertain margins, and 3 of 60 patients (5%) with negative margins (p 0.02). Patients with and without a major (named) nerve involved had crude failure rates of 18% (10 out of 55) and 9% (13 out of 143), respectively (p 0.02). There was a trend toward better local control with increasing dose. This was significant in patients with positive margins, in whom crude control rates were 40 and 88% for doses of <56 Gy and ?56 Gy, respectively (p 0.006). Actuarial 5-, 10-, and 15-year freedom from relapse rates were 68%, 52%, and 45%, respectively. Base of skull and neck failures were uncommon with or without elective treatment, developing in 2 and 3% of patients, respectively. Distant metastases were the most common type of disease recurrence, developing in 74 patients (37%) of whom 62 (31%) were disease-free at the primary site. Conclusions: Excellent local control rates were obtained in this population using surgery and postoperative radiotherapy and we recommend this combined approach for most patients with adenoid cystic carcinomas of the head and neck. Perineural invasion was an adverse prognostic factor only when a major (named) nerve was involved. Microscopic positive margins was also an adverse prognostic factor, but even when present, local control was achieved in over 80% of our patients. We recommend a dose of 60 Gy to the tumor bed, supplemented to 66 Gy for patients with positive margins. Despite effective local therapy, one-third of patients fail systemically, and good treatment to address this problem is lacking

1995-06-15

176

Genetic profiling reveals cross-contamination and misidentification of 6 adenoid cystic carcinoma cell lines: ACC2, ACC3, ACCM, ACCNS, ACCS and CAC2.  

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Adenoid cystic carcinoma (ACC) is the second most common malignant neoplasm of the salivary glands. Most patients survive more than 5 years after surgery and postoperative radiation therapy. The 10 year survival rate, however, drops to 40%, due to locoregional recurrences and distant metastases. Improving long-term survival in ACC requires the development of more effective systemic therapies based on a better understanding of the biologic behavior of ACC. Much preclinical research in this field involves the use of cultured cells and, to date, several ACC cell lines have been established. Authentication of these cell lines, however, has not been reported. We performed DNA fingerprint analysis on six ACC cell lines using short tandem repeat (STR) examinations and found that all six cell lines had been contaminated with other cells. ACC2, ACC3, and ACCM were determined to be cervical cancer cells (HeLa cells), whereas the ACCS cell line was composed of T24 urinary bladder cancer cells. ACCNS and CAC2 cells were contaminated with cells derived from non-human mammalian species: the cells labeled ACCNS were mouse cells and the CAC2 cells were rat cells. These observations suggest that future studies using ACC cell lines should include cell line authentication to avoid the use of contaminated or non-human cells. PMID:19557180

Phuchareon, Janyaporn; Ohta, Yoshihito; Woo, Jonathan M; Eisele, David W; Tetsu, Osamu

2009-01-01

177

18F-FDG PET/CT in Patients with Initially Diagnosed Adenoid Cystic Carcinoma of the Head and Neck: Clinicoplathologic Correlation  

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We evaluated 18F-FDG PET/CT findings in initially diagnosed adenoid cystic carcinoma (ACC) of the head and neck in association with pathological subtype, staging, uptake comparison with squamous cell carcinoma (SqCC) and prognosis. The subjects were 16 patients with initially diagnosed ACC of head and neck who underwent pretreatment 18F-FDG PET/CT. Histological subtype (solid pattern vs. tubular/cribriform pattern), SUVmax of size-matched SqCC of the head and neck as control group, disease-free survival (DFS) were compared with the SUVmax of ACC of the head and neck. Of total 16 patients, 6 had solid pattern and the remaining 10 had tubular/cribriform pattern. The SUVmax were significantly higher in solid pattern group than in tubular/cribriform pattern group (6.7±3.2 vs. 4.2±0.9, p=0.03). PET/CT found unexpected distant metastasis in 18.7% of patients (3/16) and changed the therapeutic plan in those patients. The SUVmax of ACC was significantly lower than that of size-matched SqCC (5.1±2.4 vs. 13.6±6.0, p18F-FDG uptake (SUVmax ?6.0) had significantly shorter DFS than those with low 18F-FDG uptake (SUVmax 18F-FDG uptake of ACC of the head and neck is significantly associated with histological subtype and DFS. 18F-FDG PET/CT may be useful for detecting unexpected metastasis. Since 18F-FDG uptake of tubular/cribriform ACC compared with SqCC is relatively low, it is necessary to interpret PET images carefully in patients without alleged ACC

2009-10-01

178

Comprehensive genomic profiling of relapsed and metastatic adenoid cystic carcinomas by next-generation sequencing reveals potential new routes to targeted therapies.  

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We hypothesized that next-generation sequencing could reveal actionable genomic alterations (GAs) and potentially expand treatment options for patients with advanced adenoid cystic carcinoma (ACC). Genomic profiling using next-generation sequencing was performed on hybridization-captured, adapter ligation libraries derived from 28 relapsed and metastatic formalin-fixed paraffin-embedded ACC. The 3230 exons of 182 cancer-related genes and 37 introns of 14 genes frequently rearranged in cancer were fully sequenced using the Illumina HiSeq 2000. All classes of GAs were evaluated. Actionable GAs were defined as those impacting targeted anticancer therapies on the market or in registered clinical trials. A total of 44 GAs were identified in the 28 ACC tumors, with 12 of 28 (42.9%) of tumors harboring at least 1 potentially actionable GA. The most common nonactionable GAs were identified in KD6MA (5 cases; 18%), ARID1A (4 cases; 14%), RUNX1 (2 cases; 7%), and MYC (2 cases; 7%). Actionable GAs included NOTCH1 (3 cases; 11%), MDM2 (2 cases; 7%), PDGFRA (2 cases; 7%), and CDKN2A/B (p16) (2 cases; 7%). Other potentially actionable GAs identified in a single case included: mutations in AKT1, BAP1, EGFR, and PIK3CA, homozygous deletion of FBXW7, and amplifications of CDK4, FGFR1, IGF1R, KDR, KIT, and MCL1. The frequency of GA in ACC is lower than that seen in the more common solid tumors. Comprehensive genomic profiling of ACC can identify actionable GAs in a subset of patients that could influence therapy for these difficult-to-treat progressive neoplasms. PMID:24418857

Ross, Jeffrey S; Wang, Kai; Rand, Janna V; Sheehan, Christine E; Jennings, Timothy A; Al-Rohil, Rami N; Otto, Geoff A; Curran, John C; Palmer, Gary; Downing, Sean R; Yelensky, Roman; Lipson, Doron; Balasubramanian, Sohail; Garcia, Lazaro; Mahoney, Kristen; Ali, Siraj M; Miller, Vincent A; Stephens, Philip J

2014-02-01

179

{sup 18}F-FDG PET/CT in Patients with Initially Diagnosed Adenoid Cystic Carcinoma of the Head and Neck: Clinicoplathologic Correlation  

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We evaluated {sup 18}F-FDG PET/CT findings in initially diagnosed adenoid cystic carcinoma (ACC) of the head and neck in association with pathological subtype, staging, uptake comparison with squamous cell carcinoma (SqCC) and prognosis. The subjects were 16 patients with initially diagnosed ACC of head and neck who underwent pretreatment {sup 18}F-FDG PET/CT. Histological subtype (solid pattern vs. tubular/cribriform pattern), SUV{sub max} of size-matched SqCC of the head and neck as control group, disease-free survival (DFS) were compared with the SUV{sub max} of ACC of the head and neck. Of total 16 patients, 6 had solid pattern and the remaining 10 had tubular/cribriform pattern. The SUV{sub max} were significantly higher in solid pattern group than in tubular/cribriform pattern group (6.7{+-}3.2 vs. 4.2{+-}0.9, p=0.03). PET/CT found unexpected distant metastasis in 18.7% of patients (3/16) and changed the therapeutic plan in those patients. The SUV{sub max} of ACC was significantly lower than that of size-matched SqCC (5.1{+-}2.4 vs. 13.6{+-}6.0, p<0.001). DFS was not significantly different according to the histological subtype. In contrast, patients with high {sup 18}F-FDG uptake (SUV{sub max} {>=}6.0) had significantly shorter DFS than those with low {sup 18}F-FDG uptake (SUV{sub max} <6.0). {sup 18}F-FDG uptake of ACC of the head and neck is significantly associated with histological subtype and DFS. {sup 18}F-FDG PET/CT may be useful for detecting unexpected metastasis. Since {sup 18}F-FDG uptake of tubular/cribriform ACC compared with SqCC is relatively low, it is necessary to interpret PET images carefully in patients without alleged ACC.

Lee, Ji Young; Choi, Joon Young; Ko, Young Hyeh; Baek, Chung Hwan; Son, Young Ik; Cho, Suk Kyong; Cheon, Mi Ju; Lee, Kyung Han; Kim, Byung Tae [Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul (Korea, Republic of)

2009-10-15

180

Carcinoma adenoescamoso do colo uterino mimetizando carcinoma adenóide basal: relato de um caso e revisão da literatura / Adenosquamous carcinoma of the cervix mimicking adenoid basal carcinoma: case report and review of the literature  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese O carcinoma adenoescamoso do colo uterino é definido como um tumor que contém uma mistura de células malignas com diferenciação escamosa e glandular. A literatura salienta a importância de se fazer esse diagnóstico, uma vez que, quando os componentes não são bem diferenciados ou não se encontram evi [...] dentes na amostra analisada, esse tumor pode ser erroneamente interpretado como carcinoma escamoso ou adenocarcinoma. O presente trabalho descreve a apresentação pouco comum de um carcinoma adenoescamoso. Após sucessivos diagnósticos citológicos não concordantes e complicados por uma história de sangramento uterino anormal ocasionado por endometriose cervical, a paciente de 47 anos foi submetida a histerectomia total, obtendo diagnóstico definitivo. Esse particular tumor aqui relatado foi diagnosticado como carcinoma adenoescamoso, mas em muitos aspectos apresentou-se semelhante ao carcinoma adenóide basal. Elementos característicos do carcinoma adenóide basal, como presença de lesão intra-epitelial escamosa na superfície, diferenciação escamosa e glandular no centro dos blocos neoplásicos e células basalóides na profundidade da lesão, foram observados em nosso caso. Em contrapartida, os seguintes elementos normalmente não observados no carcinoma adenóide basal estavam presentes: atipias e figuras de mitose nas células indiferenciadas da profundidade do tumor e lesão intra-epitelial escamomucinosa (SMILE) na superfície. Fatores epidemiológicos e clínicos, como idade (47), raça (branca) e forma de apresentação clínica (massa visível na inspeção cervical), também colaboraram para afastar esse diagnóstico diferencial. Outros diagnósticos diferenciais do carcinoma adenoescamoso do colo uterino incluem o carcinoma puramente escamoso ou glandular, o tumor de colisão e o adenocarcinoma de endométrio com diferenciação escamosa invadindo o colo uterino. Abstract in english Adenosquamous carcinoma of the uterine cervix is defined as a tumor that contains a mixture of malignant cells with squamous and glandular differentiation. The literature points to the importance of making this diagnosis when the cellular components are still well differentiated in the sample, other [...] wise the tumor may be erroneously interpreted as squamous carcinoma or adenocarcinoma. This study describes an unusual presentation of a adenosquamous carcinoma in a 47 year old patient. After conflicting cytological diagnoses and a history of abnormal uterine bleeding caused by cervical endometriosis, the patient was subjected to radical hysterectomy and a final diagnosis was obtained. The tumor was diagnosed as adenosquamous carcinoma. In many aspects, however, it was similar to the adenoid basal carcinoma. Characteristic features of the adenoid basal carcinoma such as the presence of high-grade squamous intraepithelial lesion in the surface epithelium, squamous and glandular differentiation in the center of the neoplastic mass, and basaloid cells in deep areas of the tumor were observed. Therefore, the following elements usually absent from adenoid basal carcinoma were present in this case: atypia and mitotic figures in undifferentiated cells, squamous-mucinous intraepithelial lesion (SMILE) in the superficial areas. Epidemiological and clinical data, such as patient age (47), race (white) and presentation (a cervical mass), concurred to exclude the diagnosis of adenoid basal carcinoma. Other differential diagnoses include pure squamous carcinoma or adenocarcinoma, collision tumor, and endometrial adenocarcinoma with squamous differentiation invading the uterine cervix.

Pinto, Álvaro Piazzeta; Maia, Luiz Roberto.

 
 
 
 
181

MRI of cystic collection of the three joint; Les collections kystiques du genou en IRM  

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We present the main MR features of cystic lesions around the knee joint. Popliteal cysts are the most frequently seen. The usually result from extrusion of joint fluid into the gastrocnemio-semimembranosus bursa but they can have an atypical location or extension. They are most often due to a meniscal, ligamentous, degenerative or inflammatory joint disease responsible for a chronic joint effusion. Meniscal cysts are always associated with a horizontal tear. Medial meniscal cysts are larger and can extend far from the joint. Bursitis occur as a result of inflammation or infection of a bursa. Their location is stereotyped and they do not communicate with the knee joint. Ganglion cysts or ganglia are benign cystic lesions which can affect peri-articular tissues as well as subchondral bone or cruciate ligaments. MRI is now a simple and noninvasive way of obtaining etiologic diagnosis and guiding therapy. (authors). 46 refs.

Boutry, N.; Cotten, A.; Dewatre, F.; Chastanet, P.; Gougeon, F. [Hopital R. Salengro, C.H.U., 59 - Lille (France)

1997-09-01

182

Preliminary results of radiation therapy for locally advanced or recurrent adenoid cystic carcinomas of the head and neck using combined conventional radiation therapy and hypofractionated inverse planned stereotactic radiation therapy  

International Nuclear Information System (INIS)

The purpose of this study was to investigate the clinical outcomes and feasibility of combined conventional radiation therapy (RT) and hypofractionated inverse planned stereotactic radiation therapy (SRT) for locally advanced or recurrent adenoid cystic carcinomas (ACCs) of the head and neck. Five patients with ACCs of the head and neck were treated with combined conventional RT and inverse planned SRT. Radiation doses of 40 to 50 Gy were delivered with 20 to 25 fractions using conventional RT, and then an additional 20 to 25 Gy was delivered by 4 to 5 fractions of SRT. Median follow-up was 12 months. Local control was obtained in all 5 patients, partial response (PR) in 2 patients and stable disease (SD) in 3 patients. According to the Radiation Therapy Oncology Group (RTOG) late-radiation morbidity scoring criteria, adverse effects included Grade 2 xerostomia in 1 patient, Grade 2 trismus in 1 patient, and Grade 4 mucosal ulceration in 1 patient. Combined treatment with conventional RT and hypofractionated inverse planned SRT may be effective for short-term local control in patients with locally advanced or recurrent ACCs. Further evaluation is needed for long-term follow-up. (author)

2009-02-01

183

Inverse planned stereotactic intensity modulated radiotherapy (IMRT in the treatment of incompletely and completely resected adenoid cystic carcinomas of the head and neck: initial clinical results and toxicity of treatment  

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Full Text Available Abstract Background Presenting the initial clinical results in the treatment of complex shaped adenoid cystic carcinomas (ACC of the head and neck region by inverse planned stereotactic IMRT. Materials 25 patients with huge ACC in different areas of the head and neck were treated. At the time of radiotherapy two patients already suffered from distant metastases. A complete resection of the tumor was possible in only 4 patients. The remaining patients were incompletely resected (R2: 20; R1: 1. 21 patients received an integrated boost IMRT (IBRT, which allow the use of different single doses for different target volumes in one fraction. All patients were treated after inverse treatment planning and stereotactic target point localization. Results The mean folllow-up was 22.8 months (91 – 1490 days. According to Kaplan Meier the three year overall survival rate was 72%. 4 patients died caused by a systemic progression of the disease. The three-year recurrence free survival was according to Kaplan Meier in this group of patients 38%. 3 patients developed an in-field recurrence and 3 patient showed a metastasis in an adjacent lymph node of the head and neck region. One patient with an in-field recurrence and a patient with the lymph node recurrence could be re-treated by radiotherapy. Both patients are now controlled. Acute side effects >Grade II did only appear so far in a small number of patients. Conclusion The inverse planned stereotactic IMRT is feasible in the treatment of ACC. By using IMRT, high control rates and low side effects could by achieved. Further evaluation concerning the long term follow-up is needed. Due to the technical advantage of IMRT this treatment modality should be used if a particle therapy is not available.

Jensen A

2006-06-01

184

Optimization of radiation therapy for locally advanced adenoid cystic carcinomas with infiltration of the skull base using photon intensity-modulated radiation therapy (IMRT) and a carbon ion boost  

International Nuclear Information System (INIS)

Background: Tumor doses > 70 Gy are needed for local control in adenoid cystic carcinomas. These tumor doses cannot be delivered if the tolerance doses to neighboring organs at risk (OAR) are respected. This treatment planning study investigates the physical advantage of combined photon intensity-modulated radiation therapy (IMRT) plus carbon ion boost compared to photon IMRT alone. Patients and Methods: For nine patients, treatment plans were generated using a) photon IMRT alone (integrated boost concept), and b) sum plans consisting of a photon IMRT plan and a carbon ion boost plan. 54 Gy were prescribed to the planning target volume 1 (PTV1), the boost volume (PTV2) received 72 Gy. The tolerance doses of the delineated OAR were strictly adhered to. Plan quality of IMRT plans and sum plans was compared using adequate physical parameters. Results: Both therapy techniques lead to highly conformal dose distributions that allow the prescription of the desired target doses. Target conformality and heterogeneity as well as target coverage for PTV1 are comparable for both techniques. The target coverage for PTV2 can be significantly improved using carbon ion beams (median 95% coverage 93.7% vs 87%; p = 0.039). Furthermore, the mean doses to the OAR can be reduced by 8.3% (median % reduction of mean doses to OAR; p = 0.00001) using carbon ions. Conclusions: The combination of photon IMRT with carbon ions improves the target coverage for the boost volume and offers better sparing of OAR close to the PTV2 (gross tumor volume) in comparison with photon IMRT alone. A clinical study has been initiated to evaluate whether these potential advantages translate into clinical benefit. (orig.)

2003-05-01

185

Análise quantitativa das AgNORs no carcinoma adenóide cístico intra-oral através da técnica de dupla marcação PCNA/AgNOR PCNA/AgNOR double staining technique in adenoid cystic carcinoma  

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Full Text Available A análise quantitativa das AgNORs e a imunomarcação para o PCNA têm sido empregadas de forma independente na avaliação da proliferação celular de vários tumores, e, em muitos casos, têm mostrado correlação positiva. Entretanto poucos trabalhos têm avaliado, em um mesmo corte histológico, a relação entre PCNA e AgNOR. O objetivo deste trabalho foi otimizar a técnica de dupla marcação com a finalidade de se estudar simultaneamente a correlação entre PCNA e AgNOR no carcinoma adenóide cístico (CAC de glândulas salivares menores. Foram selecionados 16 casos de CAC classificados de acordo com o subtipo histológico. A análise quantitativa das AgNORs foi feita por meio de análise de imagens. As AgNORs foram contadas em cem núcleos PCNA positivos e em cem núcleos PCNA negativos. O número médio de AgNOR nos núcleos PCNA positivos foi 2,14 ± 0,77, e, nos núcleos PCNA negativos, 1,97 ± 0,79, entretanto esta diferença não se mostrou estatisticamente significante (p = 0,2537. Nosso trabalho não mostrou correlação entre o número de AgNOR e a imunomarcação para o PCNA em CAC quando estes marcadores foram demonstrados simultaneamente através da dupla marcação. Quanto à técnica, o uso do microondas melhorou a coloração da AgNOR, permitindo uma redução no tempo de incubação com a solução de prata e uma melhor individualização das AgNORs, o que facilitou os procedimentos de contagem.No previous studies have simultaneously assessed the relationship between AgNORs and PCNA expression in salivary gland tumors. We describe a method to demonstrate both PCNA and AgNORs in the same slice of routinely processed tissue. We also evaluated the effect of microwaving on the AgNORs reaction. Sixteen cases of adenoid cystic carcinoma (ACC were selected and the double staining technique was performed in order to quantify the number of AgNORs in PCNA-positive and negative cells. The best results were obtained when AgNOR was performed after the immunostaining. The microwave oven heating improved the AgNORs staining. Our results did not show a statistical difference between the mean number of AgNORs in PCNA-negative and positive cells. There is no association between PCNA and AGNOR in ACC when they are assessed by double-staining.

Elena Riet-Correa Rivero

2002-01-01

186

Análise quantitativa das AgNORs no carcinoma adenóide cístico intra-oral através da técnica de dupla marcação PCNA/AgNOR / PCNA/AgNOR double staining technique in adenoid cystic carcinoma  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese A análise quantitativa das AgNORs e a imunomarcação para o PCNA têm sido empregadas de forma independente na avaliação da proliferação celular de vários tumores, e, em muitos casos, têm mostrado correlação positiva. Entretanto poucos trabalhos têm avaliado, em um mesmo corte histológico, a relação e [...] ntre PCNA e AgNOR. O objetivo deste trabalho foi otimizar a técnica de dupla marcação com a finalidade de se estudar simultaneamente a correlação entre PCNA e AgNOR no carcinoma adenóide cístico (CAC) de glândulas salivares menores. Foram selecionados 16 casos de CAC classificados de acordo com o subtipo histológico. A análise quantitativa das AgNORs foi feita por meio de análise de imagens. As AgNORs foram contadas em cem núcleos PCNA positivos e em cem núcleos PCNA negativos. O número médio de AgNOR nos núcleos PCNA positivos foi 2,14 ± 0,77, e, nos núcleos PCNA negativos, 1,97 ± 0,79, entretanto esta diferença não se mostrou estatisticamente significante (p = 0,2537). Nosso trabalho não mostrou correlação entre o número de AgNOR e a imunomarcação para o PCNA em CAC quando estes marcadores foram demonstrados simultaneamente através da dupla marcação. Quanto à técnica, o uso do microondas melhorou a coloração da AgNOR, permitindo uma redução no tempo de incubação com a solução de prata e uma melhor individualização das AgNORs, o que facilitou os procedimentos de contagem. Abstract in english No previous studies have simultaneously assessed the relationship between AgNORs and PCNA expression in salivary gland tumors. We describe a method to demonstrate both PCNA and AgNORs in the same slice of routinely processed tissue. We also evaluated the effect of microwaving on the AgNORs reaction. [...] Sixteen cases of adenoid cystic carcinoma (ACC) were selected and the double staining technique was performed in order to quantify the number of AgNORs in PCNA-positive and negative cells. The best results were obtained when AgNOR was performed after the immunostaining. The microwave oven heating improved the AgNORs staining. Our results did not show a statistical difference between the mean number of AgNORs in PCNA-negative and positive cells. There is no association between PCNA and AGNOR in ACC when they are assessed by double-staining.

Elena Riet-Correa, Rivero; Maria Cássia Ferreira de, Aguiar.

187

Traitement des carcinomes hépatocellulaires à un stade avancé  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Hepatocellular carcinoma is the main primitive tumor of the liver. It occurs in the setting of liver cirrhosis in more than 90% of the cases in developping countries. The prognosis depends on the size, number and extension of the tumor as well as on the severity of the underlying liver disease. The Barcelona Clinic Classification takes into account these different parameters and helps the clinician in the therapeutic decision. Some patients (around 25%) are amenable to therapy with a curative...

Daele, Daniel; Belaiche, Jacques; Delwaide, Jean; Piront, Patricia; Roover, Arnaud; Detry, Olivier; Honore, Pierre; Polus, Marc

2009-01-01

188

P53 gene snp investigation in squamous cell oesophageal carcinom  

Directory of Open Access Journals (Sweden)

Full Text Available Squamous cell cancer (ESCC and adenocarcinoma (EADC are the two main subtypes of oesophageal cancer. Genetic alterations associated with the development of oesophageal cancer are often observed. The aim of this study was to identify p53 gene polymorphisms in several patients with oesophageal squamous cell carcinoma. Genomic DNA was isolated from normal-, tumor- and blood-samples from patients with ESCC. PCR amplification of two p53 gene fragments was performed using two sets of primers DNA samples were sequenced and then analyzed with BLAST program Exons 5, 7 and 8 did not present mutations for the studied patients, but exon 6 featured one modification in two different patients. The mutations of p53 gene can determine the modification of its proteine function and the loss of its antioncogene role, which reflects the abnormal proliferation of the cells implicated in this type of cancer.

Marieta Costache

2010-06-01

189

External radiotherapy for hepatocellular carcinoma; Radiotherapie externe des carcinomes hepatocellulaires  

Energy Technology Data Exchange (ETDEWEB)

For a long time radiotherapy has been excluded from the therapeutic strategy for hepatocellular carcinoma, given its significant toxicity on the non-tumoral liver parenchyma. Conformal radiation is a recent advance in the field of radiotherapy, allowing dose escalation and combination with other therapeutic options for hepatocellular carcinoma, including trans-arterial chemo-embolization. Conformal radiotherapy is associated with interesting features, especially in cirrhotic patients: wide availability, non-invasiveness, possibility to target multiple localizations anywhere within the liver parenchyma, and favorable tolerance profile even in patients with cirrhosis and/or in a poor medical condition. Recently, radiation delivery has been optimized through several technical developments: respiratory gating and intensity-modulated radiotherapy, which allow a better focalization of the ballistics, stereotactic techniques and proton-beam radiotherapy, whose availability is currently limited in Europe. Given the high response rates of hepatocellular carcinoma to radiation, conformal radiotherapy may be regarded as a curative-intent treatment for hepatocellular carcinoma, similar to surgery and per-cutaneous techniques. Yet the impact of radiotherapy has to be evaluated in randomized trials to better integrate in the complex therapeutic algorithm of hepatocellular carcinoma. (authors)

Girard, N. [Service de pneumologie, hopital Louis-Pradel, hospices civils de Lyon, 28, avenue du Doyen-Jean-Lepine, 69500 Bron (France); UMR 754, universite Claude-Bernard Lyon-1, 43, boulevard du 11-Novembre-1918, 69622 Villeurbanne cedex (France); Mornex, F. [Departement de radiotherapie-oncologie, centre hospitalier Lyon-Sud, 165, chemin du Grand-Revoyet, 69495 Pierre-Benite cedex (France); EA 37-38, universite Claude-Bernard Lyon-1, 43, boulevard du 11-Novembre-1918, 69622 Villeurbanne cedex (France)

2011-02-15

190

Bacteremia during adenoidectomy: a comparison of suction diathermy adenoid ablation and adenoid curettage.  

LENUS (Irish Health Repository)

Transient bacteremia is induced by adenoidectomy when the integrity of the nasopharyngeal membrane is broken. The aim of this study was to determine the incidence of bacteremia in patients undergoing adenoidectomy, to identify the causative organisms, and to compare the incidences of bacteremia between the two techniques suction diathermy and curettage.

Casserly, Paula

2010-08-01

191

A diagnosis pitfall: the cystic bilateral pheochromocytoma. Discussion of a case; Un piege diagnostique: le pheocromocytome bilateral kystique. A propos d`un cas  

Energy Technology Data Exchange (ETDEWEB)

We report here the clinical history of Mrs A. (37 years old). On November 1995 Mrs A. presents stereotypical paroxysmal (2 to 3 / month) strokes of type of sensation of fast palpitations followed by very intense cephalies and sweats. The hypothesis of a pheochromocytoma has been retained, confirmed by a very important increase in the urinary metanephrines and normetanephrines and of noradrenaline. The abdominal scanner evidenced a left supra-renal tumoral lesion and also a voluminous right-renal cyst overflowing the right supra-renal. In May 1996 Mrs A. benefited by a left supra-renal-ectomy which confirmed histologically a benign pheochromocytoma. Long after the intervention the patient is totally asymptomatic but the metanephrines remains high (3000 {mu} g/24 h). The scanner applied in December 1996 finds only the voluminous right-renal cyst formation which perturbs the supra-renal exploration and rises questions about relic thymus. A scintigraphy by MIBG-{sup 131}I evidenced on the images after 24 h a hyper-fixation with hepatic projections seeming to circumscribe a voluminous right-supra-renal lacuna, confirmed by injection of 20 mCi of pertechnetate, while at 48 h this image reinforces. The diagnosis of a cystized left pheochromocytoma was established while the thymus region was normal. A scintigraphy with somatostatin labelled by indium 111 finds the anomalies superimposed on those obtained by MIBG. The patient was operated in May 1997 and a diagnosis was histologically confirmed. In conclusion, the scintigraphy by MIBG {sup 131}I must be part in the examination for suspicion of pheochromocytoma and must be interpreted together with the TDM morphological data

Devillers, A.; Bedig, G.; Garin, E.; Bouyaux, M.; Lecloirec, J. [CHG St Brieuc CRLCC Eugene Marquis Rennes (France)

1997-12-31

192

Irradiation of low rectal cancers; Radiotherapie des carcinomes du bas rectum  

Energy Technology Data Exchange (ETDEWEB)

The low rectal cancers are treated by anorectal amputation and pose the problem of the sphincter conservation. Some authors extend the clinical definition to developed injuries until 12 cm from the anal margin. The rectal cancer is a frequent tumour which remains serious. When the tumour is low, the treatment consists in an anorectal amputation with a permanent colostomy. The radical non preserving surgery is the usual treatment of these injuries. Until 1960 the rectal adenocarcinoma was considered as a radioresistant tumour because of the impossibility to deliver an enough dose to the tumour by external radiotherapy. But other studies showed that those lesions were radiosensitive and often radiocurable. The medical treatments haven`t yet demonstrated their efficiency in the treatment of the rectal cancer. We`ll study the radiotherapy in the treatment of the low rectal cancer, solely radiotherapy, radiosurgical associations. 32 refs., 5 tabs.

Ardiet, J.M.; Coquard, R.; Romestaing, P.; Fric, D.; Baron, M.H.; Rocher, F.P.; Sentenac, I.; Gerard, J.P. [Centre Hospitalier Lyon-Sud, 69 -Pierre-Benite (France)

1994-12-31

193

Non-surgical management of hepatocellular carcinoma; Prise en charge non chirurgicale du carcinome hepatocellulaire  

Energy Technology Data Exchange (ETDEWEB)

Most of patients with hepatocellular carcinoma (HCC) cannot benefit from surgical therapies. Among non-surgical options, only radiofrequency can challenge surgery for small size tumours. Conformal radiotherapy is likely highly efficient on solitary tumours, but controlled studies are warranted to conclude. Other options are purely palliative. Trans-arterial hepatic chemo-embolization is the goal-standard for multifocal hepatocellular carcinoma and Sorafenib for hepatocellular carcinoma with portal vein invasion, leading to modest but significant benefit on survival rates. Yttrium-90 radio-embolization is under evaluation through controlled studies, and could be of major interest for multifocal hepatocellular carcinoma with or without portal venous invasion. (authors)

Merle, P. [Service d' hepato-gastroenterologie, hopital de l' Hotel-Dieu, 69 - Lyon (France); Inserm U871 -Oncogenese hepatique et hepatites virales-, 69 - Lyon (France); IFR62 Lyon-Est, universite Lyon 1, 69 - Lyon (France); Mornex, F. [Departement de radiotherapie-oncologie, centre hospitalier Lyon-Sud, 69 - Pierre-Benite (France)

2010-10-15

194

Skeleton scintigraphy and radiologic data at 403 patients with prostata carcinom  

International Nuclear Information System (INIS)

In a retrospective study 403 patients with prostatic carcinoma (PC) were examined to shed light on the relation between the rate of metastases and the stage of local tumor spread as well as the histomorphologic tumor type; to establish the rate of metastases detected by bone scanning versus radiology; and to compare the contributions of bone scanning versus radiology in monitoring the response of bone metastases to treatment. Results: (1) The rate of metastases was found to increase as a function of primary tumor size and increasing dedifferentiation; however, bone metastases were also seen in highly differentiated stage O and A PC. (2) Solitary metastases were confined to the pelvic bones and lumbar vertebrae. (3) About one third of all bone metastases were radiologically silent; in sporadic cases receiving contrasexual therapy they remained silent for more than 5 years. (4) Bone scnaning showed 73.3% of patients to respond to contrasexual therapy and 26.7% to be non- responders. (6) There were some differences or even discrepancies between bone scans and radiology in documenting the results of treatment. Conclusions: Repeated bone scans are required for monitoring the course of the disease even if the primary tumor is extremely small and histologically well differentiated. Bone scans are superior to radiology in detecting metastases. While repeat X-rays during the course of a disease furnish important information, they are unsuited for monitoring the response to treatment. (Author)

1982-01-01

195

Sorafenib and radiotherapy association for hepatocellular carcinoma; Sorafenib et radiotherapie dans le carcinome hepatocellulaire  

Energy Technology Data Exchange (ETDEWEB)

Conformal radiotherapy is a promising therapeutic strategy for hepatocellular carcinoma (HCC), producing local control rates above 90% within the radiation beam. However, survival after radiotherapy remains limited by the high frequency of intra- and extra-hepatic recurrences, which occurs in 40-50 and 20-30% of cases, respectively. Sorafenib (BAY43-9006, Nexavar; Bayer, West Haven, CT) is a small molecule inhibitor that demonstrated potent activity to target v-raf murine sarcoma oncogene homologue B1 (BRAF) and VEGFR tyrosine kinases. Sorafenib is the only drug that demonstrated effectiveness to increase overall survival in advanced or metastatic hepatocellular carcinoma. The rationale to combine radiotherapy with sorafenib is the following: (1) targeting RAS-RAF-MAPK and VEGFR signaling pathways, which are specifically activated after exposure to radiation, and responsible for radio-resistance phenomenon; (2) enhancing the oxygen effect through normalization of the surviving tumor vasculature; and (3) synchronization of the cell cycle. Sorafenib and radiotherapy represent complementary strategies, as radiotherapy may be useful to prolong the effect of sorafenib through control of the macroscopic disease, when sorafenib may target latent microscopic disease. Sorafenib and radiotherapy associations are thus based on a relevant biological and clinical rationale and are being evaluated in ongoing phase I-II trials. (authors)

Girard, N. [Service de pneumologie, hopital Louis-Pradel, hospices Civils de Lyon, 28, avenue du Doyen-Jean-Lepine, 69500 Bron (France); UMR 754, universite Claude-Bernard Lyon 1, 43, boulevard du 11-novembre-1918, 69622 Villeurbanne cedex (France); Mornex, F. [UMR 754, universite Claude-Bernard Lyon 1, 43, boulevard du 11-novembre-1918, 69622 Villeurbanne cedex (France); Departement de radiotherapie-oncologie, centre hospitalier Lyon Sud, 165, chemin du Grand-Revoyet, 69495 Pierre-Benite cedex (France)

2011-02-15

196

Thyroid carcinoma, hyperthyroidism and iodine intake; Carcinome thyroidien, hyperthyroidie et apport iode  

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The absolute iodine intake, slowly ameliorated, in a population influences the epidemiology of thyroid carcinoma (TC) and of hyperthyroidism (HT). We have retrospectively evaluated the frequencies of associated TC and HT in a pre-Alpine region over a period amounting up to more than 30 years. The iodide salt (5 - 10 - 20 mg KI/kg since 1922 - 1962 - 1980) have progressively corrected the severe iodine deficit, prevailing at the beginning of century. The patients treated for TC by surgery and/or {sup *}I in our hospital have been grouped in 3 periods: A (before 1971), B (1971 - 1983) and C (1984 - 1996), according to the diagnosis of malignity. Recorded were the number/type of associated TC (histology/or cytology) and HT (blood/clinic/scintigraphy by {sup *}I dosages). (GB = disease of Graves-Basedow, UFA/MFA = HT by uni- or multifocal functional autonomy, FC = follicular C, PC = papillary C, AC anaplas.C). On 925 TC, the FC has fallen from 64% down to 32%, the TC increased from 25% up to 60%, while the AC and other different C were of stable frequencies. The low frequency of AC has remained stable and it was not associated to HT. The associated HT (n = 97) were UFA in 60% to 13%, MFA (around {+-} 30%) and GB in 10% to 40% of cases. In conclusion, at 70 years since its introduction, the effect of iodide salt remains beneficent. Actually, the epidemiologic evolution described in 1963 by Walthard maintains. Due to the continues slope down of FC and up of PC in Berne during the period 1945 -1996 the general prognostication of TC continues to improve 16 years after the last augmentation of iodine in salt in Switzerland. The general decrease of UFA following the major correction of iodine deficit explains its less frequent association with the TC

Als, C.; Netzer, P.; Gedeon, P.; Glaser, C.; Seiler, C.; Markwalder, R.; Laissue, J.; Roesler, H. [Universite de Berne, Berne (Switzerland)

1997-12-31

197

Prophylactic cranial irradiation in small-cell lung cancer; Irradiation prophylactique cerebrale dans les carcinomes bronchiques a petites cellules  

Energy Technology Data Exchange (ETDEWEB)

In small-cell lung cancer, there is a high risk of cranial relapse, which may reach nearly 50% at 2 years in patients in complete remission following appropriate induction treatment. Several randomized studies have shown that prophylactic cranial irradiation reduces the risk of tumour dissemination by 2- to 3-fold. However, prophylactic cranial irradiation remains a controversial issue due to its potential neurotoxicity, which has been reported in a number of small-scale retrospective studies, and also because of the absence of a significant effect on overall survival observed in the various randomized trials, which were not carried out on a sufficientlylarge scale. In contradiction with these findings, a recently published meta-analysis evaluating the role of prophylactic cranial irradiation in complete responders not only confirmed its positive effect on the incidence of brain metastases at 3 years, but also showed an absolute increase in overall survival of 5%. It is concluded that prophylactic cranial irradiation should therefore be considered as part of the standard treatment in small-cell lung cancer complete responders. However, several questions still remain unanswered, such as the optimal radiation dose to be prescribed, the optimal time interval between induction treatment and cranial irradiation, and the long-term evaluation of possible late sequelae. These issues should be examined in further prospective studies. (author)

Bardet, E. [Centre Regional de Lutte contre le cancer Nantes-Atlantique Rene-Gauducheau, 44 - Saint-Herblain (France); Le Pechoux, C. [Institut Gustave Roussy, 94 - Villejuif (France)

1999-11-01

198

Primitive epidermoid breast carcinoma. About 13 cases; Carcinome epidermoide primitif du sein. A propos de 13 cas  

Energy Technology Data Exchange (ETDEWEB)

Purpose: to enhance the epidemiological, clinical, histologic, therapeutic, prognostic and progressive characteristics of primitive squamous cell carcinomas of the breast. Conclusion: The primitive pure squamous cell carcinomas of the breast are rare. The clinic and radiological aspects are not specific. The treatment stands on the surgery with axillary lymph node dissection. The adjuvant treatment associates radiotherapy and chemotherapy, which type is still to precise, hormones therapy is recommended in the rare cases where the hormone receptors are expressed. Their prognosis is in general unfavourable. (N.C.)

Masbah, O.; Kebdani, T.; Bouhafa, O.; Bekkouch, I.; Mellas, N.; Kanouni, L.; Hassouni, K.; Benjaafar, N.; El Gueddari, B.K. [Service de Radiotherapie, Rabat (Morocco)

2009-10-15

199

Place of radiotherapy in tonsil carcinomas; Place de la radiotherapie dans les carcinomes de l`amygdale  

Energy Technology Data Exchange (ETDEWEB)

Oropharynx carcinomas are generally located at the level of palatine tonsil and are characterized by a great frequency of locally advanced steps. The radiotherapy keeps an important place in therapy. This has been demonstrated for a long time because the only surgery, maiming, could not be used in wide localizations. In fact, after the experience of 110 cases, exposed here, and with the comparison of others authors, it is concluded that radiotherapy must be used in first intention, surgery coming after it, only in compensation. (N.C.). 13 refs., 1 fig., 1 tab.

Sahraoui, S.; Acharki, A.; Samlali, R.; Benider, A.; Kahlain, A.

1995-12-31

200

Radio-embolization for hepatocellular carcinoma; Traitement des carcinomes hepatocellulaires par injection intra-arterielle de radio-isotopes  

Energy Technology Data Exchange (ETDEWEB)

Hepatocellular carcinoma is now a major public health concern. In intermediate stages (one third of hepatocellular carcinoma patients), chemo-embolization is the standard of care despite a poor tolerance and a moderate efficacy. Moreover, despite recent improvements, this technique seems in a dead end. Radio-embolization could be an excellent tool for such patients. Currently {sup 131}I-Lipiodol, {sup 188}Re-Lipiodol, {sup 90}Y-glass or resin microspheres are available. More recent and promising data come from microspheres, but phase II and III studies are needed before drawing any conclusion. In the future, the combination of radio-embolization with systemic chemotherapy or targeted agents (particularly anti-angiogenic drugs) seems very promising. (authors)

Raoul, J.L. [Departement d' oncologie medicale, centre Eugene-Marquis, rue de la bataille Flandres-Dunkerque, CS 44229, 35042 Rennes cedex (France); Inserm U911, centre Eugene-Marquis, CS 44229, 35042 Rennes cedex (France); Edeline, J.; Pracht, M.; Boucher, E. [Departement d' oncologie medicale, centre Eugene-Marquis, rue de la bataille Flandres-Dunkerque, CS 44229, 35042 Rennes cedex (France); Rolland, Y. [Departement d' imagerie medicale, centre Eugene-Marquis, CS 44229, 35042 Rennes cedex (France); Garin, E. [Inserm U911, centre Eugene-Marquis, CS 44229, 35042 Rennes cedex (France); Departement d' imagerie medicale, centre Eugene-Marquis, CS 44229, 35042 Rennes cedex (France)

2011-02-15

 
 
 
 
201

Reirradiation by Cyberknife of head and neck carcinomas; Reirradiation par Cyberknife de carcinomes de la tete et du cou  

Energy Technology Data Exchange (ETDEWEB)

In spite of local treatment the local defeat is a problem in O.R.L. cancerology. It has been demonstrated that some recurrences or second cancers in beforehand irradiated area could be sterilized by a new irradiation of high dose after perfect definition of the volume to treat and the certainty that recurrence will be localized.Numerous works have allowed to underline that a part of patients, with an O.R.L. recurrence can be treated again with curative aim with survival rate about 20 to 20 % at three years. The objective of this study was to test with a phase two study, the validation of a stereotaxic type reirradiation by Cyberknife associated to Cetuximab. (N.C.)

Balajouza Kanoun, S.; Lacornirie, T.; Coche Dequeant, B.; Mirabel, X.; Lefebvre, J.L.; Lartigau, E. [Centre Oscar-Lambret, Univ. de Lille-2, Dept. Universitaire de Radiotherapie, 59 - Lille (France)

2007-11-15

202

Analysis of the economic impact of cystic echinococcosis in Spain / Analyse de l'impact économique de l'échinococcose kystique en Espagne / Análisis del impacto económico de la hidatidosis en España  

Scientific Electronic Library Online (English)

Full Text Available SciELO Public Health | Language: English Abstract in spanish OBJETIVO: Estimar las pérdidas económicas totales ocasionadas por la hidatidosis humana y animal en España en 2005. MÉTODOS: Los datos sobre la incidencia anual de la hidatidosis se obtuvieron a partir de los registros de vigilancia epidemiológica y de los mataderos. Los datos sobre el tratamiento y [...] la pérdida de productividad (humana y animal) relacionada con la enfermedad se obtuvieron a partir de la literatura científica. Los costes directos fueron los asociados al diagnóstico, el tratamiento quirúrgico o farmacológico, la atención médica y la hospitalización en humanos, y los decomisos de vísceras infectadas en animales de abasto (ganado ovino, caprino, bovino y porcino). Los costes indirectos comprendieron la pérdida de productividad en humanos y la reducción de las tasas de crecimiento, fecundidad y producción de leche en el ganado. Para representar la incertidumbre asociada a los parámetros analizados se utilizó el método del hipercubo latino. RESULTADOS: Las pérdidas económicas totales atribuibles a la hidatidosis humana y animal fueron estimadas en 148 964 534 euros (€) (intervalo de credibilidad del 95%, IC95%: 21 980 446-394 012 706). Las pérdidas estimadas de origen humano fueron de € 133 416 601 (IC95%: 6 658 738-379 273 434), y de € 15 532 242 (IC95%: 13 447 378-17 789 491) las de origen animal. CONCLUSIÓN: La hidatidosis es una zoonosis desatendida que en España sigue constituyendo un problema de salud humana y animal. Son necesarios datos más exactos sobre la prevalencia de la hidatidosis en humanos (sobre todo en los casos no diagnosticados o asintomáticos) y mejores métodos para calcular la pérdida de productividad en animales. La hidatidosis sigue afectando a ciertas zonas de España pese a las varias campañas de control emprendidas desde 1986. Dada la gran carga económica de la hidatidosis, es necesaria una mayor financiación para reducir las tasas de infección humana y animal mediante mejoras en la vigilancia de la enfermedad, el tratamiento periódico de los perros y la cooperación entre organismos oficiales. Abstract in english OBJECTIVE: To estimate the overall economic losses due to human and animal cystic echinococcosis (CE) in Spain in 2005. METHODS: We obtained data on annual CE incidence from surveillance and abattoir records, and on CE-related treatment and productivity losses (human and animal) from the scientific [...] literature. Direct costs were those associated with diagnosis, surgical or chemotherapeutic treatment, medical care and hospitalization in humans, and condemnation of offal in livestock (sheep, goats, cattle and pigs). Indirect costs comprised human productivity losses and the reduction in growth, fecundity and milk production in livestock. The Latin hypercube method was used to represent the uncertainty surrounding the input parameters. FINDINGS: The overall economic loss attributable to CE in humans and animals in 2005 was estimated at 148 964 534 euros (€) (95% credible interval, CI: 21 980 446-394 012 706). Human-associated losses were estimated at €133 416 601 (95% CI: 6 658 738-379 273 434) and animal-associated losses at €15 532 242 (95% CI: 13 447 378-17 789 491). CONCLUSION: CE is a neglected zoonosis that remains a human and animal health concern for Spain. More accurate data on CE prevalence in humans (particularly undiagnosed or asymptomatic cases) and better methods to estimate productivity losses in animals are needed. CE continues to affect certain areas of Spain, despite several control initiatives since 1986. Given the high economic burden of CE, additional funding is needed to reduce human and animal infection rates through improved disease surveillance, regular treatment of dogs and greater cooperation between agencies.

Christine, Benner; Hélène, Carabin; Luisa P, Sánchez-Serrano; Christine M, Budke; David, Carmena.

203

Supra-scapular nerve entrapment by ganglion cyst. Value of imaging modalities; Compression kystique du nerf sus-scapulaire. Interet de l`imagerie. A propos de 6 cas et revue de la litterature  

Energy Technology Data Exchange (ETDEWEB)

Six cases of supra-scapular nerve entrapment by a ganglion cyst within the spino-glenoid notch or developed from the glenoid labrum are reported. Causes of injury or entrapment of the supra-scapular nerve are described including traction or kinking of the nerve, trauma, repetitive exercise, or compression by ganglion cyst. The patients had non specific pain, weakness, and atrophy of the spinatus musculature. Electromyography showed evidence of denervation atrophy. Patients had plain radiographs, arthrography, CT-arthrography, magnetic resonance imaging (MRI) and MR-arthrography. Masses that caused supra-scapular nerve entrapment were well localized and characterized with magnetic resonance imaging, reflecting the superior soft-tissue contrast of this modality. In addition, MRI may demonstrate atrophy of the spinatus muscles. MR-arthrography allows to visualize lesions of the glenoid labrum and in some cases, demonstrates cysts filling. (authors). 35 refs.

Levy, Ph.; Roger, B.; Tardieu, M.; Ghebontni, L.; Thelen, Ph.; Richard, O.; Grenier, Ph. [Hopital Pitie-Salpetriere, 75 - Paris (France)

1997-09-01

204

Carcinoma adenóide cístico: relato de caso = Adenoid cystic carcinoma: case report  

Directory of Open Access Journals (Sweden)

Full Text Available O carcinoma adenóide cístico é uma neoplasia maligna rara de crescimento lento, caracterizado prognóstico reservado, devido a sua agressividade e grande potencial recidivante. A lesão é mais prevalente em pacientes na faixa etária entre 50 e 70 anos, sendo incomum em jovens. O artigo relata um caso de carcinoma adenóide cístico de glândulas salivares menores localizado no palato duro em pacientes com 26 ano, do sexo masculino que foi encaminhado para tratamento no Serviço de Cirurgia de Cabeça e Pescoço.

Palmeiro, Mariana Reuter et al.

2005-01-01

205

Results of fast neutron therapy of adenoid cystic carcinoma of the salivary glands  

International Nuclear Information System (INIS)

72 consecutive patients with ACC were treated with fast neutrons, 66 after surgery, 6 for primarily unresectable disease, 43/66 for macroscopic residual disease, 23/66 for unresectable recurrent disease. 45/72 tumors were localized in the minor, 27 in the major salivary glands. T-stage was in 13 pts T2, in 33 T3, in 26 T4; positive nodes were in 10 pts. M+ in 15 pts. Mean tumor volume was 89 cm3. Neutron therapy was 15.03 Gy in 3 weeks with 1.67 Gy per fraction three times per week. Individual computer assisted treatment planning was performed based on CT and/or MRI, using bolus material if necessary. Target volume was the macroscopic tumor volume with a generous safety margin. Results: Complete response was achieved in 28 pts, partial response in 35 pts. Local control was observed in 73.4% after a mean observation period of 36 months. Overall and recurrence free survival was 85%/81% at two years, and 58%/53% at 5 years (Kaplan-Meier). In univariate analysis tumor volume (> 100 cm3), distant metastases, histologic subtype (solid) and neutron dose (<15 Gy) turned out to be significant parameters for predicting outcome, in multivariate analysis tumor volume and histologic subtype remained the only significant parameters. Acute morbidity was grade III/IV (EORTC/RTOG) in 6% for skin (desquamation), in 4% for mucosa (ulceration), late morbidity (grade III/IV) in one patient with local temporal brain necrosis. (orig.)

1999-06-01

206

Epidermoid carcinomas of the anal margin treated by curative goal irradiation; Carcinomes epidermoides de la marge anale traites par irradiation a visee curative  

Energy Technology Data Exchange (ETDEWEB)

Purpose: to evaluate the toxicity, the local control rate and the survival of patients suffering of an epidermoid carcinoma of the anal margin treated by curative and conservative irradiation. Conclusion: the excision should be reserved for small tumors away from the anal canal. The curative radiotherapy is recommended for the tumors with incomplete resection and for that ones of big volume or localised near the anal canal. (N.C.00.

Huguet, F.; Touboul, E.; Schlienger, M. [Hopital Tenon, 75 - Paris (France); Tiret, E.; Godeberge, P.; Contou, J.F. [Hopital Saint-Antoine, 75 - Paris (France); Soudan, D. [Institut Mutualiste Montsouris, 75 - Paris (France); Roseau, G. [Hopital Leopold-Bellan, 75 - Paris (France)

2009-10-15

207

COMPARISON AND EVALUATION OF VALUE OF THYROGLOBULIN LEVEL IN SERUM AND 1-131 WHOLE BODY SCAN (1-131 WBS IN PATIENTS WITH DIFFERENTIATED THYROID CARCINOM  

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Full Text Available This study was done in research institute of nuclear medicine from 1988-1992 for evaluation of the value of serum thyroglobulin level in comparison with 1-131 whole body scan (1-131 WBS in patients with differentiated thyroid carcinoma. 204 patients who had total or near total thyroidectomy treated with 1-131 were evaluated in this study. Out of 204 patients 136 did not have regional or distant metastases. 68 patients had recurrence and metastases in which 42 cases showed good correlation between hTG and 1-131 WBS. In 14 cases with recurrence and metastases only 1-131 WBS was diagnostic and in 12 cases hTG was diagnostic while 1-131 WBS was negative. With the help of other diagnostic modolities such as Tl-201, chest X-ray biopsy and repeated 1-131 WBS during 5 years of follow-up regional recurrence and metastases were diagnosed. Serum hTG level for diagnosis of recurrence and metastases hud a sensitivity of 79.4%, specificity 90.4% and accuracy of 86.8% while 1-131 WBS had sensitivity of 82.3%, accuracy of 94.1% and specificity of 100%.  

A. Vakili

1998-06-01

208

Re-irradiation of local relapses of patients treated for a nasopharyngeal undifferentiated carcinoma; Reirradiation des recidives locales des patients traites pour carcinome indifferencie du nasopharynx  

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The authors report a retrospective a study based on eight men and five women who have been treated for a local relapse of a nasopharyngeal carcinoma, and who have been re-irradiated between 2003 and 2008. The relapse was either local or local and ganglionary. The relapse stage was either I, II or III. The authors aimed at assessing the re-irradiation toxicity. Results are encouraging, but a combination of external radiotherapy and curie-therapy could improve the local control rate. Short communication

Zenati, S.; Hamzi, L.; Afiane, M. [Centre Pierre-et-Marie-Curie, Alger (Algeria); Zenati, S.; Afiane, M. [Faculte de medecine, Alger (Algeria)

2010-10-15

209

Post irradiation eardrum: a rare complication of the radiotherapy of naso-pharynx carcinomas; Necrose tympanique postradique: une complication rare de la radiotherapie des carcinomes nasopharynges  

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The eardrum necrosis is a serious and dreadful complication but rarely described after irradiation of cavum cancers. We report in this work five cases of eardrum necrosis after radiotherapy of nasopharynx carcinomas. Patients and methods: between february 1993 and december 2004 239 patients suffering of anon metastatic nasopharynx cancer have been treated by classical irradiation associated or not to a chemotherapy. The radiotherapy was delivered at the dose of 70 to 75 Gy in the cavum and the ganglions initially reached according a classical modality of hyperfractionated one. We analysed retrospectively the delayed complications occurred six months or more after the radiotherapy beginning. Results: Five cases of eardrum necrosis were reported sixty five months after the end of radiotherapy. these patients suffered of hypoacusia and buzzing. The clinical examination allowed to bring out the eardrum perforation that did not exist before radiotherapy. The total dose of irradiation was 75 Gy for a patient and 71.5 Gy according a hyperfractionated modality for four patients. Three patients had an hearing prosthesis in order to improve their quality of life. Conclusion: the eardrum necrosis after radiotherapy for nasopharynx cancer is a rare and unusual complication, very few reported in the literature. The total dose of irradiation is considered as the principal factor of occurrence risk in such complication. (N.C.)

Siala, W.; Mnejja, W.; Daoud, J. [CHU Habib-Bourguiba, Service de Radiotherapie Oncologique, Sfax (Tunisia); Khabir, A. [CHU Habib-Bourguiba, Service d' Anatomopathologie, Sfax (Tunisia); Ghorbel, A. [CHU Habib-Bourguiba, Service d' ORL, Sfax (Tunisia); Frikha, M. [CHU Habib-Bourguiba, Service d' Oncologie Medicale, Sfax (Tunisia)

2009-10-15

210

Apport de la pathologie intégrative dans l'identification de biomarqueurs dans les carcinomes pulmonaires non à petites cellules : pathologie intégrative et cancer du poumon  

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Le cancer pulmonaire non à petites cellules (CNPC) est la première cause de décès par cancer dans le monde. Ce cancer est souvent découvert tardivement, il est agressif, et il est chimio-résistant. La découverte de biomarqueurs pourraient représenter une percée majeure pour la prise en charge de ces patients, en facilitant le diagnostic, le pronostic et orienter vers le choix du traitement le plus approprié. Nous avons exploré plusieurs aspects liés à la progression tumorale dans...

Ilie, Marius Ionut

2013-01-01

211

Hypopharyngeal squamous cell carcinoma: retrospective study of 149 treatments in curative aimed; Carcinome epidermoide de l'hypopharynx: etude retrospective de 149 traitements a visee curative  

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Purpose. - Hypopharyngeal squamous cell carcinoma is associated to one of the most unfavorable prognosis among the cancers of the head and neck. The purpose of this study is to analyze its therapeutic modalities in the Salah-Azaiz Institute (Tunis) and to compare their results. Patients and method. - This retrospective study concerns 271 hypopharyngeal squamous cell carcinomas, compiled in the Carcinologic Surgery Department of Head and Neck of the Salah-Azaiz Institute over a period of 25 years (from 1977 to 2002). The average age of the patients was of 56 years; sex-ratio was on average of 1.2 (man/woman). The indication of a curative treatment was initially retained for 149 (55%) patients, who were the only ones retained for the analysis of results. Results. - We retained the indication of a protocol including surgery and post-operating radiotherapy for 26.2% of the patients. Post-operation mortality rate was 5.1%; the operating rate of morbidity was 46.2%. For 13.5% of the patients, post-operating radiotherapy was permanently interrupted because of a gradual deterioration of the patients' health in the course of treatment. We retained the indication of exclusive radiotherapy for 59.7% of the patients. The average age was of 56 years and the sex-ratio of 1.2. The external radiotherapy was conventional. Radiotherapy had to be permanently interrupted in progress in 32.6% of cases on account of an deterioration of the patients' health; the rate of morbidity of the radiotherapy was 33.3%. We indicated a protocol of conservation of organ with induction chemotherapy for 21 patients (14.1%). The average age was of 53 years (28-65 years) and sex-ratio (man/woman) of 0.5. The global survival was 25.5% at one year, 18.1% at two years, 11.4% at three years and 7.4% at five years. All the patients selected for chemotherapy died in the course of treatment. The rates of survival in two and five years according to protocols surgery-radiotherapy and exclusive radiotherapy were respectively: 21.5 and 12%, and 18.3 and 10%. The difference between the rates of survival of this two protocols is not significant (P =0.08). Conclusion. - Although the induction chemotherapy entails a particularly high death rate in our series, the association surgery-radiotherapy and the exclusive radiotherapy seem to be similarly efficient for the treatment of the hypopharyngeal carcinoma. (author)

Oueslati, Z.; Zeglaoui, I.; Touati, S.; Gritli, S.; Ladgham, A. [Institut Salah-Azaiz, Service de Chirurgie Carcinologique et ORL, Tunis (Tunisia); Nasr, C.; Benna, F. [Institut Salah-Azaiz, Service de Radiotherapie, Tunis (Tunisia); Boussen, H. [Institut Salah-Azaiz, Service de Chimiotherapie, Tunis (Tunisia); Mokni, N.; Gamoudi, A.; El-May, A. [Institut Salah-Azaiz, Service de d' Immunohistochimie, Tunis (Tunisia)

2004-12-01

212

Chemoradiotherapy in head and neck squamous cell carcinoma: focus on targeted therapies; La chimioradiotherapie des carcinomes epidermoides des voies aerodigestives superieures: point sur les therapeutiques ciblees  

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Radiotherapy is an essential treatment for many patients with head and neck squamous cell carcinoma. Its association with molecular targeted therapies represents a real progress. Among the recent advances in the molecular targeted therapy of cancer, the applications centred on E.G.F.R. are currently the most promising and the most advanced at clinical level. Considering the set of therapeutic tools targeting E.G.F.R., there are at present two well-identified emerging categories of drugs with monoclonal antibodies, on the one hand, and tyrosine kinase inhibitors, on the other. In many preclinical studies, the combination of anti-E.G.F.R. drugs with irradiation has led to additive or supra-additive cytotoxic effects. Furthermore, anti-angiogenic agents have shown promising results in association with anti-E.G.F.R. drugs and radiotherapy. This research effort has recently produced encouraging clinical results in advanced head and neck cancer with combination of cetuximab (an anti-E.G.F.R. monoclonal antibody) with irradiation with a significant impact on patient survival. Active and efficient clinical research is currently ongoing to determine the place of molecular targeted therapies in the treatment of head and neck cancer, particularly in association with radiotherapy. (authors)

Bozec, A. [Centre Antoine-Lacassagne, Dept. de Chirurgie, Institut Universitaire de la Face et du Cou, 06 - Nice (France); Thariat, J.; Bensadoun, R.J. [Centre Antoine-Lacassagne, Dept. de Radiotherapie, Institut Universitaire de la Face et du Cou, 06 - Nice (France); Milano, G. [Centre Antoine-Lacassagne, Unite d' Oncopharmacologie, Institut Universitaire de la Face et du Cou, 06 - Nice (France)

2008-01-15

213

About a bilateral radio-induced mammary carcinoma; A propos d'un cas de carcinome mammaire bilateral radio-induit  

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The authors report the case of a woman who developed two mammary cancers, in a metachronous and bilateral way, 18 and 23 years after a pulmonary bilateral irradiation which occurred when taking into care an osteo-carcinoma of the lower limb at the age of 13. After the first and second mammary carcinoma diagnosis, she was submitted to chemotherapy and to radiotherapy. The authors precisely describe the observed carcinomas. Short communication

Belajouza, S.; Sayed, N.B.; Bouaouina, N. [Service de cancerologie-radiotherapie, CHU Farhat-Hached, Sousse (Tunisia)

2010-10-15

214

Contribution of radiotherapy in the treatment of cavum carcinomas at Yaounde; Apport de la radiotherapie dans le traitement des carcinomes du cavum a Yaounde  

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A lot of works show that cavum carcinomas make of Cameroon an area at intermediary risks non negligible. The radiotherapy seems to be the only efficient technique but it is still non well known in our hospitals. This works wants to plaid in favor of its acknowledge and its optimal use by showing its contribution and its application difficulties. 5 refs., 1 tab.

Yomi, J.; Fouda, A.; Maloum, E.; Bengono, G.

1995-12-31

215

Retrospective analysis of 108 ductal carcinomas in situ of the breast treated by radiosurgery association; Analyse retrospective de 108 carcinomes canalaires in situ mammaires traites par association radiochirurgicale  

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Purpose. - To evaluate survival and prognostic factors of 108 patients with clinically or mammo-graphically detected ductal carcinoma in situ (DCIS), treated from 1980 to 1996 by complete local excision followed by external irradiation. Patients and methods. - The median age was 51 (range 37-80). All the patients underwent surgery consisting of a wide resection of the mammary gland harboring the tumour. The surgical specimens were sent to the pathologists to get information on histology and margin clearance; all the slides were reviewed by one of us to assess the tumoral diameter. External beam therapy was delivered within 8 weeks after surgery. The prescribed irradiation dose was 50 Gy in 25 fractions to be given in 5 weeks. The median duration of follow-up was 93 months (range 40-173). Results. - There were nine patients with local recurrence (8.3%); three patients had local recurrence of DCIS and six patients developed invasive breast cancer. The treatment of local recurrence consisted of mastectomy with or without axillary dissection (eight cases) and quadrant-ectomy (one case). The 5-year and 10-year ipsilateral recurrence-free rate was respectively 92 and 89%. The 10-year cause specific survival was 100%. In univariate analysis, size {>=} 10 mm, age < 45 years old and margin status were significant P = 0,02. P 0,03, P = 0,005; margin status was significant in multivariate analysis (P < 0,02). Conclusion. - These results are in keeping with those of the literature. They could be improved by the mass screening campaign, which is going on since January 1990 among women aged 50 - 74 years. (authors)

Fourneret, P.; Artignan, X.; Cornulier, J. de; Kolodie, H.; Vincent, F.; Colona, M.; Bolla, M. [CHU de Grenoble, Service de cancerologie-radiotherapie, 38 - Grenoble (France); Pasquier, D. [CHU de Grenoble, Service d' anatomopathologie, 38 - Grenoble (France); Bernard, P. [CHU de Grenoble, Service de gynecologie, 38 - Grenoble (France); Payan, R. [Clinique Belledone, 38 - Saint-Martin-D' Heres (France); Frice, D. [Clinique du Mail, 38 - Grenoble (France); Colona, M.; Bolla, M. [Office Dept. de lutte contre le cancer, 38 - Meylan (France); Panh, M.H. [Registre du cancer de l' Isere, 38 - Meylan (France)

2006-12-15

216

Age influence on naso-pharynx carcinomas prognosis after chemoradiotherapy; Influence de l'age sur le pronostic des carcinomes nasopharynges apres chimioradiotherapie  

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The recurrence modes were not different before and after seventy years. The conformal radiotherapy in classical fractionation can be realised for subjects over 70. The triplets are not easily used in chemotherapy of induction after 70 years, as the concomitant chemotherapy by cisplatin. The optimization perspectives include targeted therapies, and the lympho-therapy anti-Epstein-barr virus, especially in the aged subpopulations. (N.C.)

Thariat, J.; Peyrade, F.; Marcy, P.Y.; Guevara, N.; Dassonville, O.; Doglio, A.; Benezery, K.; Ortholan, C.; Bensadoun, R.J.; Santini, J. [Centre Antoine-Lacassagne, 06 - Nice (France)

2009-10-15

217

Trans-arterial chemo-embolization and conformal radiotherapy for hepatocellular carcinoma; Chimioembolisation et radiotherapie de conformation dans le traitement du carcinome hepatocellulaire  

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Hepatocellular carcinoma is a poor prognosis tumour. The potential curative therapeutic options are ortho-topic liver transplantation, surgical resection and radiofrequency ablation. Unfortunately, only a minority of patients (around 20%) are eligible for these techniques. Thus, patients can benefit from palliative options, such as trans-arterial chemo-embolization (TACE) or sorafenib that bring only modest benefit on survival. Conformal radiotherapy allows delivering high dose radiation within a precise tumour volume while sparing the surrounding liver parenchyma. As employed in mono-therapy, conformal radiotherapy is highly efficient for small size hepatocellular carcinoma (< 5 cm). Above 5 cm, its efficacy is more limited but its association with TACE gives spectacular rates of complete responses. Controlled phase 2 or 3 trials are urgently warranted to define its indications in the therapeutic algorithm of hepatocellular carcinoma. (authors)

Merle, P. [Service d' hepatogastroenterologie, hopital de l' Hotel-dieu, 1, place de l' Hopital, 69002 Lyon (France); Inserm U871, equipe ' Oncogenese hepatique et hepatites virales' , 151, cours Albert-Thomas, 69003 Lyon (France); Universite Claude-Bernard Lyon 1, IFR62 Lyon-Est, 8, avenue Rockefeller, 69008 Lyon (France); Mornex, F. [Departement de radiotherapie-oncologie, centre hospitalier Lyon-Sud, chemin du Grand-Revoyet, 69310 Pierre-Benite (France); equipe ' Ciblage therapeutique par les agents physiques' , EA 37-38, universite Claude-Bernard Lyon 1, 43, boulevard du 11-Novembre-1918, 69622 Villeurbanne cedex (France)

2011-02-15

218

Von Hippel-Lindau and myotonic dystrophy of Steinert along with pancreatic neuroendocrine tumor and renal clear cell carcinomal neoplasm: Case report and review of the literature  

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INTRODUCTION Myotonic dystrophy of Steinert, DM1, is the most common adult muscular dystrophy and generally is not associated to development on multiple site neoplasm. Von Hippel-Lindau (VHL) disease is a dominantly inherited familial cancer syndrome that is associated to tumors such as hemangioblastoma of the retina or central nervous system, clear-cell renal carcinoma (RCC) and endocrine tumors, most commonly pheochromocytoma and non-secretory pancreatic islet cell cancers. No data exist in literature describing the coexistence of both DM1 and VHL. PRESENTATION OF CASE Herein we report a case of renal and pancreatic neoplasm in a young adult female affected by DM1 and VHL simultaneously. DISCUSSION DM1 is due to an unstable trinucleotide (CTG) expansion in the 30 antranslated region of the dystrophia myotonica-protein kinase (DMPK) gene, located on chromosome 19q13.3. Several molecular mechanisms thought to be determining the classical DM phenotype have been shown. VHL disease is characterized by marked phenotypic variability and the most common tumors are hemangioblastomas of the retina or central nervous system, clear-cell renal carcinoma (RCC) and endocrine tumors, most commonly pheochromocytoma and non-secretory pancreatic islet cell cancers. The pancreatic manifestations seen in patients with VHL disease are divided into 2 categories: pancreatic neuroendocrine tumor (PNET) as solid tumors, and cystic lesions, including a simple cyst and serous cystadenoma. The surgical approach for these cistic lesions is to consider as golden standard. Blansfield has proposed 3 criteria to predict metastatic disease of PNET in patients with VHL disease: (1) tumor size greater than or equal to 3 cm; (2) presence of a mutation in exon 3; and (3) tumor doubling time less than 500 d. If the patient has none of these criteria the patient could be followed with physical examination and radiological surveillance on a 2/3 years base.4 If the patient has 1 criterion, the patient should be followed more closely every 6 months to 1 year. If the patient has 2 or 3 criteria, the patient should be considered for surgery given the high risk of future malignancy. Our patient owned only one criterion but in presence of a second malignant tumor. Our hypothesis for this rare findings is that both DM and VHL might be derived from genetic aberration and these might be linked to a major cancer susceptibility. As far as we know this is the first confirmed case of RCC and neuroendocrine pancreatic cancer occurring concurrently with VHL and, at the same time, DM1. According to this case report and the literature data a VHL should be ruled out in the presence of RCC presenting along with pancreatic cysts/tumor. CONCLUSION As far as we know this is the first confirmed case of RCC and neuroendocrine pancreatic cancer occurring concurrently with VHL and, at the same time, DM1. Our hypothesis for the unusual findings is that both DM and VHL derived from genetic aberration and these are linked to a major cancer susceptibility.

Addeo, A.; Bini, R.; Viora, T.; Bonaccorsi, L.; Leli, R.

2013-01-01

219

Postoperative Adjuvant Radiotherapy for Adenoid Cystic Carcinoma of the Head and Neck: Treatment Results and Prognostic Factors.  

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Full Text Available Background: To analyze the treatment results and prognostic factors of patients with adenoidcystic carcinoma (ACC arising from the major and minor salivaryglands of the head and neck, and who received postoperative radiotherapyafter radical tumor resection.Methods: Between October 1987 and December 1999, 25 patients with ACC of thehead and neck were treated with radical surgical resection and postoperativeadjuvant irradiation without chemotherapy. Using appropriate radiation techniquesto the tumor bed, total doses ranged from 44 to 68.4 Gy. All patientshad a minimum of 2 years of follow-up.Results: The 5-year overall survival rate, local control rate, and distant metastasis-freerate were 75%, 83%, and 66%, respectively. To the present, 2 patients hadexperienced recurrence at the primary sites, and 1 had regional lymph nodemetastasis. Distant metastases developed in 7 patients (28%, of whom 6(86% were disease-free at the primary site. The lung was the most commondistant metastatic site. In multivariate analysis, the only statistically significantprognostic factor for a distant metastasis-free rate was the stage at presentation( p = 0.009.Conclusion: Patients with an advanced stage of disease had higher distant metastasis rateseven when receiving postoperative radiotherapy. Distant metastasis is stillthe main problem in the management of ACC of the head and neck.However, more-effective treatment for this problem is still lacking.

Hsuan-Chih Hsu

2003-09-01

220

Systemic Amyloidosis Complicating Dermatoses.  

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Certain dermatoses may be complicated by systemic amyloidosis. The underlying disorders in eight of 100 patients with secondary systemic amyloidosis studied at autopsy were: hidradenitis suppurativa, stasis ulcers, psoriatic arthritis, basal cell carcinom...

M. H. Brownstein E. B. Helwig

1970-01-01

 
 
 
 
221

Influence of MRI abnormality in skull base bone on prognosis of nasopharyngeal carcinoma; Influence de l'atteinte asseuse de la base du crane par IRM sur le pronostic des carcinomes nasopharynges  

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Purpose. To evaluate the influence of skull base bone (SBB) abnormality showed by MRI on prognosis of nasopharyngeal carcinoma (NPC). Patients and methods. From March 1993 to December 1998, 122 NPC patients received prime radiotherapy treatment. All of them were proved pathologically and checked by magnetic resonance imaging (MRI). Every patient received radiation through conjoint facio-cervical field and conventional dose-fractionation schedules. The total dose to the primary tumor was 60 5 Gy (median, 70 Gy). The Kaplan Meier method, the Log-rank test and the Cox regression model were used to evaluate the significance of prognostic factors on NPC patient survival. Results. The overall median survival period was 50 (6 2) months, and the 1, 3 and 5 year-survival rates were, respectively, 99.2%, 87.9%, and 73.3%. The 1, 3, and 5 year-survival rates of abnormality and normality of the SBB on MRI were 98.9%, 87.2%, 71.9%, and 100.0%, 89.8%, 77.0%, respectively (P 0.4233). Gender, age, head pain, SBB abnormality, cranial nerve palsy, cervical lymphadenopathy and primary tumor extent were analyzed with the Cox regression model and SBB abnormality on MRI did not prove to have statistical significance (P = 0.6934). According to the analysis of regrouping, patients with SBB abnormalities {>=} sites have a worse prognosis (P = 0.0427). Then. the above seven factors are analyzed by Cox regression model and the result had statistical significance (P = 0.0385). Conclusion. The SBB abnormality on MRI is of no obvious influence on prognosis of NPC. However, when SBB abnormality sites were {>=} 2, there is obvious statistical significance on the prognosis. (author)

Jin-Cheng, Lu; Qing, Wei; Yi-Qin, Zhang; Feng, Li [Jiangsu Cancer Hospital, Dept. of Radiotherapy, Nanjing (China)

2004-08-01

222

Retrospective study of the local control and the cosmetic result of 147 face carcinomas after interstitial brachytherapy; Etude retrospective du controle local et du resultat cosmetique de 147 carcinomes de la face apres curietherapie interstitielle  

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The purpose was to evaluate retrospectively the local control rate and the cosmetic results for patients that received an interstitial brachytherapy for a base or spino-cellular carcinoma of face orifices areas. The interstitial brachytherapy by iridium 192 is an excellent alternative to surgery in the skin carcinomas of the face, as well at the level of local control as the cosmetic and functional results. (N.C.)

Ducassou, A.; David, I.; Bonnet, J.; Delannes, M. [Institut Claudius-Regaud, Service de Radiotherapie, 31 - Toulouse (France)

2009-10-15

223

Class T4 (Stage 3B) epidermoid carcinomas of the anal channel; Carcinomes epidermoides du canal anal classes T4 (stade 3B): traitement conservateur par irradiation ou irradiation preoperatoire  

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The local control rate with a correct anal function is low after radiotherapy with curative aim with or without concomitant chemotherapy. For the patients whom the tumoral response is under 50% after the first irradiation fractions and/or that have a bad anal function even before therapy (scores 3-4), the sphincter preservation is compromised and the conservative treatment is questionable. (N.C.)

Deniaud-Alexandre, E.; Touboul, E.; Huguet, F.; Pene, F.; Schlienger, M. [Hopital Tenon APHP, Service d' Oncologie-Radiotherapie, 75 - Paris (France); Tiret, E.; Parc, R. [Hopital Saint-Antoine, APHP, Service de Chirurgie Digestive, 75 - Paris (France); Sezeur, A. [Groupe Hospitalier des Diaconesses-Croix Saint-Simon, Service de Chirurgie Digestive, 75 - Paris (France); Hannoun, L. [Groupe Hospitalier Pitie-Salpetriere APHP, Service de Chirurgie Digestive, 75 - Paris (France); Houry, S. [Hopital Tenon APHP, Service de Chirurgie Digestive, 75 - Paris (France)

2006-11-15

224

Nasopharyngeal carcinoma. Clinical diagnosis, external radiotherapy and brachytherapy. Status of the art in 2001; Carcinomes du nasopharynx. Aspects cliniques, indications et resultats de la radiotherapie transcutanee et de la curietherapie. Etat de la question en 2001  

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Nasopharynx carcinomas (NPC) are a very special head and neck cancer, in term of epidemiology, clinic and pathology. Endemic disease in South East Asia, undifferentiated nasopharynx carcinoma are very frequent CT scan and NMR allow a better knowledge of the modalities of the clinical presentation. Prognostic factors include local and regional extension. NPC is a well known radiosensitive disease with a dose-response curve well established. Modern imaging modalities and modification of the ballistic explain the amelioration of the local control and the diminution of therapeutic sequelae. Brachytherapy is an interesting modalities for the boost and the treatment of recurrent disease. The exact place of 3 D CRT and IMRT is not yet known as modifications of fractionation. Local control for T1 T2 tumor is excellent but is related to clinical extension (cranial and neurologic involvement) and nodal extension (supra clavicular N3) and show the interest of combined chemo-radiotherapy protocols. (authors)

Eschwege, F.; Bourkhis, J. [Institut Gustave Roussy, Dept. de Radiotherapie, 94 - Villejuif (France); El Gueddari, B. [Institut National d' Oncologie, Rabat (Morocco)

2001-11-01

225

Nasopharynx carcinoma treatment: from the conventional radiotherapy to the conformal radiotherapy with intensity modulation; Traitement du carcinome du nasopharynx: de la radiotherapie conventionnelle a la radiotherapie conformationnelle avec modulation d'intensite  

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The objective of this study was to evaluate retrospectively the impact of factors linked to the radiotherapy realisation on the local and locoregional control, the global survival, the survival without disease of patients suffering of naso-pharynx carcinoma. Conclusion: the patients suffering of a nasopharynx carcinoma treated by irradiation associated to chemotherapy have an improved global survival and an improved survival without disease. The conformal radiotherapy with or without modulated intensity reduce the risk of serous otitis, trismus and xerostomia at long term. It seems necessary to realize multi centric studies with a longer period of follow up before asserting the advantages of the I.M.R.T. in comparison to the classical and conformal technique in the treatment of naso-pharynx carcinomas. (N.C.)

Mokaouim, K.; Grehange, G.; Truc, G.; Peingnaux, K.; Martin, E.; Zanetta, S.; Bruchon, Y.; Bonnetain, F.; Maingon, P. [Centre Georges-Francois Leclerc, 21 - Dijon (France)

2009-10-15

226

What extension evaluation before therapy have we to do in the nasopharynx cancers?; Quel bilan d'extension pretherapeutique faut-il faire dans les carcinomes du nasopharynx?  

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NMR imaging has proved its superiority on scanography in the study of limits and tumor extension and should be the first examination. The practice of of a scanography or cervical NMR should be the best mean of ganglions evaluation. As regards the extension evaluation at distance, it is recommended to require systematically a thorax radiograph and a bone scintigraphy for any patient. The liver echography is rather indicated among male patients, aged between 40 and 45 and having a stage 3 lymph node (according to the U.I.C.C. 1997 classification). (N.C.)

Elloumi, F.; Mnejja, W.; Siala, W.; Daoud, J. [Centre Hospitallie Universitaire Habib-Bourguiba, Service de Radiotherapie Carcinologique, Sfax (Tunisia); Hammami, B.; Ghorbel, M. [Centre Hospitallie Universitaire Habib-Bourguiba, Service ORL, Sfax (Tunisia); Frikhan, M. [Centre Hospitallie Universitaire Habib-Bourguiba, Service de Carcinologie Medicale, Sfax (Tunisia)

2007-11-15

227

Preoperative scintigraphic detection of lung metastases of a follicular thyroid carcinoma associated with hyperthyroidism; Detection scintigraphique preoperatoire de metastases pulmonaires d'un carcinome vesiculaire de la thyroide associe a une hyperthyroidie  

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Preoperative accumulation of radioiodine in metastases of thyroid carcinoma and its association with hyperthyroidism are uncommon. We report a case of 58-year-old woman with follicular thyroid carcinoma revealed by thyrotoxicosis caused by a hot nodule, and bilateral pulmonary uptake of I-131 before total thyroidectomy. Despite four ablative doses of I-131, bone metastases were identified and the patient died 42 month after the initial diagnosis. (authors)

Biyi, A.; Oufroukhi, Y.; Doudouh, A. [Hopital Militaire d' Instruction Mohammed V, Rabat Instituts, Service de Medecine Nucleaire, Rabat (Morocco); Baizri, H.; El Quatni, M. [Hopital Militaire d' Instruction Mohammed V, Service d' Endocrinologie, Rabat (Morocco); Al Bouzidi, A. [Hopital Militaire d' Instruction Mohammed V, Service d' Anatomie Pathologique, Rabat (Morocco)

2009-10-15

228

Clear cell carcinoma of the larynx: one case report and review of the literature; Carcinome a cellules claires du larynx: revue de la litterature, a propos d'un cas  

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Clear cell carcinoma of the larynx is exceptional. Only six cases are described in the literature. We report a new case occurring in a 58-year-old man. The treatment consisted of a total laryngectomy with lymph node dissection followed by adjuvant irradiation. Local and regional recurrence occurred after 5 months. The patient died from the tumor's evolution 12 months after the diagnosis. The prognosis of clear cell carcinoma of the larynx is similar to the clear cell carcinoma of the lung and is unfavorable. (authors)

Sahraoui, S.; Acharki, A.; Kahlain, A.; Belaabidia, B.; Sqali, S. [Centre Hospitalier Universitaire Ibn Rochd, Casablanca (Morocco)

2001-04-01

229

Prospective study of accelerated postoperative radiation therapy in patients with squamous-cell carcinoma of the head and neck; Radiotherapie externe acceleree postoperatoire des carcinomes epidermoides localement evolues de la sphere ORL: etude prospective de phase 2  

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Purpose. - To assess the feasibility and efficacy of accelerated postoperative radiation therapy (RT) in patients with squamous-cell carcinoma of the head and neck (SCCHN). Patients and methods. - Between December 1997 and July 2001, 68 patients (male to female ratio: 52/16; median age: 60-years (range: 43-81)) with pT1-pT4 and/or pN0-pN3 SCCHN (24 oropharynx, 19 oral cavity, 13 hypopharynx, 5 larynx, 3 unknown primary, 2 maxillary sinus, and 2 salivary gland) were included in this prospective study. Postoperative RT was indicated because extra-capsular infiltration (ECT) was observed in 20 (29%), positive surgical margins (PSM) in 20 (29%) or both in 23 patients (34%). Treatment consisted of external beam R 66 Gy in 5 weeks and 3 days. Median follow-up was 15 months. Results. -According to CTC 2.0, acute morbidity was acceptable: grade 3 mucositis was observed in 15 (22%) patients, grade 3 dysphagia in 19 (28%) patients, grade 3 skin erythema in 21 (31%) patients with a median weight loss of 3.1 kg (range: 0-16). No grade 4 toxicity wa observed. Median time to relapse was 13 months; we observed only three (4%) local and four (6%) regional relapses, whereas eight (12%) patients developed distant metastases without any evidence of locoregional recurrence. The 2 years overall-, disease-free survival, an actuarial locoregional control rates were 85, 73 and 83% respectively. Conclusion.- The reduction of the overall treatment time using postoperative accelerated RT with weekly concomitant boost (six fraction per week) is feasible with local control rates comparable to that of published data. Acute RT related morbidity is acceptable. (author)

Zouhair, A.; Coucke, P.A.; Azria, D.; Moeckli, R.; Mirimanoff, R.O.; Ozsahin, M. [Centre Hospitalier Universitaire Vaudois CHUV, Service de Radio-Oncologie, Lausanne (Switzerland); Azria, D. [Centre Regional de Lutte Contre le Cancer Val-d' Aurelle-Paul-Lamarque, Dept. d' Oncologie- Radiotherapie, 34 - Montpellier (France); Pache, P. [Centre Hospitalier Universitaire Vaudois CHUV, Service d' ORL, Lausanne (Switzerland); Stupp, R. [Centre hospitalier Universitaire Vaudois CHUV, Centre Pluridisciplinaire d' Oncologie Medicale, Lausanne (Switzerland)

2003-08-01

230

The place of radiotherapy in muco-epidermoid carcinomas of salivary glands in child; Place de la radiotherapie dans les carcinomes mucoepidermoides des glandes salivaires de l'enfant  

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As muco-epidermoid carcinomas are the most frequent tumours of salivary glands for child, the authors report the study of the role of radiotherapy. This study is based on a survey performed in 34 paediatric departments. The authors analyse the age and gender, the use of irradiation, the tumour location, the tumour grade and size, the use of surgery and of radiotherapy, and survival. Radiotherapy is beneficial for high grade tumours, but cannot be recommended for low and intermediate grades. Short communication

Thariat, J. [Centre Antoine-Lacassagne, Nice (France); Temam, S. [Institut Gustave-Roussy, Villejuif (France); Orbach, D. [Institut Curie, Paris (France); Nicollas, R.; Penicaud, M. [Hopital La Timone, Marseille (France); Toussaint, B. [CHU, Nancy (France); Makeieff, M. [CHU, Montpellier (France); Laprie, A. [Institut Claudius-Regaud, Toulouse (France); Castillo, L. [CHU, Nice (France); Vedrin, P. [CHC de Cannes, Cannes (France)

2011-10-15

231

Neck dissection following chemo radiation for node positive head and neck carcinomas;Place du curage ganglionnaire apres chimioradiotherapie dans les carcinomes epidermoides des voies aerodigestives superieures avec atteinte ganglionnaire initiale (nasopharynx exclu)  

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The optimal timing and extent of neck dissection in the context of chemo radiation for head and neck cancer remains controversial. For some institutions, it is uncertain whether neck dissection should still be performed up front especially for cystic nodes. For others, neck dissection can be performed after chemo radiation and can be omitted for N1 disease as long as a complete response to chemo radiation is obtained. The question is debated for N2 and N3 disease even after a complete response as the correlation between radiological and clinical assessment and pathology may not be reliable. Response rates are greater than or equal to 60% and isolated neck failures are less than or equal to 10% with current chemo radiation protocols. Some therefore consider that systematic up front or planned neck dissection would lead to greater than or equal to 50% unnecessary neck dissections for N2-N3 disease. Positron-emission tomography (PET) scanning to assess treatment response and have shown a very high negative predictive value of greater than or equal to 95% when using a standard uptake value of 3 for patients with a negative PET at four months after the completion of therapy. These data may support the practice of observing PET-negative necks. More evidence-based data are awaited to assess the need for neck dissection on PET. Selective neck dissection based on radiological assessment and preoperative findings and not exclusively on initial nodal stage may help to limit morbidity and to improve the quality of life without increasing the risk of neck failure. Adjuvant regional radiation boosts might be discussed on an individual basis for aggressive residual nodal disease with extra-capsular spread and uncertain margins but evidence is missing. Medical treatments aiming at reducing the metastatic risk especially for N3 disease are to be evaluated

Thariat, J. [Centre de lutte contre le cancer Antoine-Lacassagne, Dept. de Radiotherapie, Oncologie, 06 - Nice (France); IBDC CNRS UMR 6543, 06 - Nice (France); Thariat, J.; Marcy, P.Y.; Bozec, A.; Peyrade, F.; Hofman, P. [Universite de Nice-Sophia-Antipolis, 06 - Nice (France); Hamoir, M. [Cliniques universitaires Saint-Luc, UCL, Dept. de chirurgie ORL, Bruxelles (Belgium); Janot, F. [Institut Gustave-Roussy, Dept. de chirurgie ORL, 94 -Villejuif (France); De Mones, E. [CHU de Bordeaux, Dept. de chirurgie ORL, 33 - Bordeaux (France); Marcy, P.Y. [Centre de lutte contre le cancer Antoine-Lacassagne, Dept. de Radiologie, 06 - Nice (France); Carrier, P. [CHU de Nice, Dept. de Medecine Nucleaire, 06 - Nice (France); Bozec, I. [Centre de lutte contre le cancer Antoine-Lacassagne, Dept. chirurgie ORL, 06 - Nice (France); Guevara, J.; Santini, J. [CHU Pasteur, Dept. de chirurgie ORL, 06 - Nice (France); Albert, S. [CHU Bichat, Dept. de chirurgie ORL, 75 - Paris (France); Vedrine, P.O. [CHG Cannes, 06 (France); Graff, P. [Centre de Lutte Contre le Cancer Alexis-Vautrin, Dept. de chirurgie ORL, 54 - Nancy (France); Peyrade, F. [Centre de lutte contre le cancer Antoine-Lacassagne, Dept. d' Oncologie Medicale, 06 - Nice (France); Hofman, P. [CHU de Nice, Dept. de Pathologie clinique et experimentale, 06 - (France); Centre de lutte contre le cancer Antoine-Lacassagne, CHU et tumorotheque CHU-CLCC, 06 - Nice (France); Bourhis, J. [Institut Gustave-Roussy, Dept. de Radiotherapie-oncologie, 94 - Villejuif (France); Lapeyre, M. [Centre de lutte contre le cancer Jean-Perrin, Dept. de Radiotherapie-oncologie, 63 - Clermont-Ferrand (France)

2009-12-15

232

Re-irradiation in stereotactic conditions and cetuximab for local relapses of epidermoid carcinoma of head and neck; Reirradiation en conditions stereotaxiques et cetuximab pour des recidives locales de carcinome epidermoide de la tete et du cou  

Energy Technology Data Exchange (ETDEWEB)

The authors report a work aimed at assessing the feasibility and toxicity of a re-irradiation treatment in stereotactic conditions using CyberKnife and cetuximab in the case of local relapses of epidermoid cancers of the ORL sphere. Thirty three patients have been submitted to this treatment between June 2007 and April 2009. Although six patients died by six months, this treatment seems to be a good alternative, and presents an acceptable short-term toxicity. Further studies are needed to compare this technique to other therapeutic techniques, and to assess the risk of long term complications. Short communication

Vasseur, F.; Comet, B.; Faivre-Pierret, M.; Coche-Dequeant, B.; Degardin, M.; Lefebvre, J.L.; Lacornerie, T.; Lartigau, E. [Departement universitaire de radiotherapie, centre Oscar Lambret, 59 - Lille (France); Universite Lille-2, 59 (France)

2010-10-15

233

Optimisation of combination radiotherapy and chemotherapy in non-small cell lung cancer; Optimisation de l`association radiotherapie et chimiotherapie dans les carcinomes bronchiques non a petites cellules  

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To report the results of CEBI 1 40 and 1 42 trials. These trials were aimed at improving the local control in stage III non-small cell carcinoma with concomitant chemotherapy and radiotherapy in the CEBI 140 trial, and with concomitant chemotherapy and radiotherapy followed by local excision in the CEBI 142 trial. In the CEBI 140 trial, all the patients received a complete course of radiotherapy, but the dose of cisplatin was decreased in 27 % of the cases, and the dose of vindesin in 88 %. There were two toxicity-related deaths. Three months after completion of the protocol, there were 50 % of complete responders. The overall survival rates at 1,2 and 3 years were 53, 33, and 11 % respectively, and disease-free survival rates 21, 11, and 11 %, respectively. In the CEBI 142 trial the immediate tolerance was good. Twenty-one patients (75 %) underwent surgical resection. Four tumors could not be resected. Resection was histologically incomplete in one case, and complete in the 16 remaining cases. With a median follow-up of 14 months, ten patients were alive and disease-free. Preliminary results of the CEBI 142 trial are encouraging. More patients and longer follow-up are needed for definitive conclusion. It would be of interest to implement a randomized trial comparing the CEBI 142 scheme and classical radiation therapy. (author). 11 refs.

Bretel, J.J.; Arriagada, R.; Le Chevalier, T.; Baldeyrou, P.; Grunenwald, D.; Le Pechoux, C.; Pellae-Cosset, B.; Ruffie, P. [Institut Gustave Roussy, 94 - Villejuif (France)

1997-09-01

234

Dealing with initial chemotherapy doses: a new basis for treatment optimization in limited small-cell lung cancer; Importance de la dose initiale de chimiotherapie dans le traitement des carcinomes bronchiques a petites cellules: perspectives therapeutiques  

Energy Technology Data Exchange (ETDEWEB)

Treatment of patients with small-cell lung cancer (SCLC) remains disappointing despite high initial complete response rates. The dramatic initial chemosensitivity of tumor cells is frustrated by the early emergence of chemoresistant clonogenic cells, regardless of front line treatments. Although the dose relationship is fairly well established regarding the response rate, its effect on survival is inconclusive. From 1980 to 1988, 202 patients with limited SCLC were included in four consecutive protocols using an alternating schedule of thoracic radiotherapy and chemotherapy. Despite an increase of chemotherapy and/or total radiation doses, no significant difference was observed between the four protocols in terms of response rate, disease free and overall survival. However, a retrospective analysis performed on a total of 131 consecutive patients led us to propose the hypothesis that a moderate increase in the initial dose, ie first course, of cisplatin and cyclophosphamide could improve overall survival. From 1988 to 1991, 105 patients were subsequently included in a large randomized trial raising this question. The treatment difference only concerned the initial doses of cisplatin (80 vs 100 mg/m{sup 2}) and cyclophosphamide (900 vs 1200 mg/m{sup 2}). The trial was closed after inclusion of 105 patients, 32 months after the start of the study because at that time overall survival was significantly better in the higher-dose group (p = 0.001). The emergence of this debatable concept opens new directions in the therapeutic strategy of SCLC and the contribution of hematopoietic growth factors may be a great interest in the management of this disease. (authors). 27 refs., 1 tab.

Le Chevalier, T.; Le Cesne, A.; Arriagada, R. [Centre de Lutte Contre le Cancer Gustave-Roussy, 94 - Villejuif (France)

1995-12-31

235

Tonsillectomy and Adenoidectomy  

Medline Plus

Full Text Available ... mouth. The tonsils are part of the immune system and help fight infections. Eustachian tube The adenoids ... The adenoids are also part of the immune system and help fight infections. The uvula is also ...

236

olea40d13  

Full Text Available olea40d13 Clone name olea40d13 Library olea 5' end seq. ID olea40d13 [NBRP] Acc. of 5' end DK058 ecapentaplegic homolog 4 (SMAD 4) (Mothers against DPP homolog 4) (Deletion target in pancreatic carcinom

237

Childhood Allergic Diseases of the Upper Respiratory Tracts.  

Science.gov (United States)

The report discusses the most frequent childhood allergic diseases: allergic rhinosinusopathies, allergic adenoiditis, acute subligamentous laryngitis, allergic laryngotracheitis, asthmatic bronchitis, and bronchial asthma.

A. G. Likhachev

1974-01-01

238

21 CFR 874.4420 - Ear, nose, and throat manual surgical instrument.  

Science.gov (United States)

...knife); tracheal dilator; tracheal hook; laryngeal injection set; laryngeal knife; laryngeal saw; laryngeal trocar; laryngectomy tube; adenoid curette; adenotome; metal tongue depressor; mouth gag; oral screw; salpingeal curette;...

2010-04-01

239

Check-up and follow-up of papillary and follicular thyroid carcinoma in the department of nuclear medicine at Ibn Sina hospital Rabat; Bilan et surveillance des carcinomes papillaire et vesiculaire de la thyroide dans le service de medecine nucleaire de l'hopital Ibn Sina de Rabat  

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In the department of nuclear medicine at Ibn Sina university hospital. Thyroid carcinoma follow-up strategy has been modified and includes cervical ultrasonography and thyroglobulin measurement. The role of radio-iodine scanning in the management of differentiated thyroid carcinoma is decreasing. Papillary and follicular carcinoma have good prognosis but late metastases exist and can lead to death. A lifelong follow-up is therefore mandatory. The main goal of follow-up is to detect earlier persistent or recurrent disease. (authors)

Ben Rais Aouad, N.; Ghfir, I.; Guerrouj, H.; Fellah, S.; Rahali, J.; Ksyar, R.; Missoum, F.; Bssis, A.; Azrak, S. [CHU Ibn Sina, Service de Medecine Nucleaire, Rabat (Morocco)

2009-10-15

240

Study of the correlation between immunohistochemistry of the initial tumor and PET/CT after recombining TSH (RHTSH) in case of tumor recurrence in differentiated thyroid carcinomas; Etude de la correlation entre l'immunohistochimie de la tumeur initiale et la TEP-FDG/TDM apres TSH recombinante (RHTSH) en cas de recidive tumorale dans les carcinomes thyroidiens differencies  

Energy Technology Data Exchange (ETDEWEB)

Purpose: In patients with differentiated thyroid carcinoma, the correlation between the value of thyroglobulin and the positivity of F.D.G.-PET remains controversial. We looked at whether the immunohistochemical criteria of the original tumor could be predictive of a positive PET in cases of tumor recurrence. Conclusions: on a larger series, we have not confirmed the results of Hooft (JCEM 2005). This study did not reveal immunohistochemical marker, present in the original tumor, which would be predictive of a positive PET-F.D.G. in the search for a recurrence. The study of NIS and GLUT1 expression is underway. (N.C.)

Lansoy-Kuhn, C.; Mechken, F.; Edet-Sanson, A.; Vera, P. [Centre Becquerel and QuantIF LITIS EA4108, Service de medecine nucleaire, 76 - Rouen (France); D' anjou, J.; Cornic, M. [Centre Henri-Becquerel, service anatomopathologie, 76 - Rouen (France)

2010-07-01

 
 
 
 
241

Statistical study of a series of 672 carcinomas of the cervix: results and complications according to age and modalities of treatment; Etude statistique d`une serie de 672 carcinomes du col uterin. Resultats et complications selon l`age et les modalites de traitement  

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The study on 672 infiltrating carcinomas of the cervix treated from 1977 until the end of 1991, by a radiosurgical combination or by exclusive irradiation. The radiosurgical series includes stages 1 B and II and patients under 50 years because of the therapeutic protocol. Most of the patients over 50 years and all stages III were treated by exclusive irradiation. External beam irradiation was most often performed in 4 fields by linear accelerator of 12 and 25 MeV. Utero vaginal brachytherapy used the technique of molds. In 55 cases, a complementary interstitial brachytherapy was applied on residual node. A computer dosimetry was made for each patient with calculation of the doses delivered to organs at risk and to node areas . The results at 5 years are as follows for the total series: locoregional control (LRC) 79%, specific survival (SS) 73%, overall survival 70%. For stage I, the LRC of the radiosurgical series is 92%, that of the series of exclusive irradiation 87%. For stage II, the LRC is 70% in the radiosurgical series and 79% in the series of exclusive irradiation. Conversely, for distal stage II, the difference is very significant in favour of exclusive irradiation (LRC 31%/77%, SS 26%/70%). If we consider the results according to age, the difference for distal stage II comes mostly from patients under 50 years and especially those aged 40 years or under. For stage III, the LRC is 61% for patients over 50 years and 34% for those aged 50 years or under. As the nodes, the results of surgical pieces and lymphadenectomy are studied. The patients under 40 years in stages II and III present more metastases than others. Among the therapeutic factors, the dose rate and the treatment duration were particularly studied. A detailed study of the complications is made for the radiosurgical series as for the series of exclusive irradiation according to the French Italian glossary of complications as well as a study of the factors inducing them.

Pernot, M.; Hoffstetter, S.; Peiffert, D.; Carolus, J.M.; Guillemin, F.; Verhaeghe, J.L.; Marchal, C.; Luporsi, E.; Beckendorf, V.; Stines, J.; Aletti, P.; Dartois, D.; Lesur, A.; Bey, P. [Centre de Lutte Contre le Cancer, 54 - Nancy (France)

1995-12-31

242

Conservative treatment of epidermoid carcinomas of the anal duct by external irradiation followed by low dose rate brachytherapy by iridium 192; Traitement conservateur des carcinomes epidermoides du canal anal par irradiation externe suivie de curietherapie de bas debit de dose par Iridium 192  

Energy Technology Data Exchange (ETDEWEB)

The association of external radiotherapy and brachytherapy is an efficient loco regional treatment of epidermoid carcinomas of the anal duct with an acceptable delayed toxicity rate and a high rate of the sphincter function conservation. (N.C.)

Minsat, M.; Moureau-Zabotto, L.; Giovannini, M.; Lelong, B.; Viret, F.; Bories, E.; Tallet, A.; Salem, N. [Institut Paoli-Calmettes, 13 - Marseille (France)

2007-11-15

243

{sup 18}FDG and external radiotherapy. The point of view of the radiotherapist.; application of the techniques of fusion imaging to radiotherapy of non-small-cell lung carcinoma; {sup 18}FDG et radiotherapie externe, le point de vue du radiotherapeute.: application des techniques de fusion d'images a la radiotherapie des carcinomes bronchiques  

Energy Technology Data Exchange (ETDEWEB)

The prognosis of patients with localized non-small-cell lung carcinoma and treated with radiation therapy remains poor. The three-dimensional conformational radiotherapy aims to increase the dose of radiation at the tumor volume to increase the local control, while sparing the healthy tissue neighborhood. The reduction of the safety margins and the irradiated volumes obliges to determine with most acute precision the exact tumor volume. However, the scanner alone is insufficient, particularly at the mediastinal level and at a distance. The positron emission tomography allows distinguishing a biological tumor volume. It helps to define the lung tumor volume, especially when the tumor is accompanied by atelectasis, and to recover the lymph node staging at the mediastinal level and at a distance. Even if the sensibility and the specificity are not 100 %, positron emission tomography now becomes essential before considering an escalation of thoracic radiation dose.

Deniaud-Alexandre, E. [Centre Hospitalier de la Cote-Basque, Service d' Oncologie, 64 - Bayonne (France)

2008-10-15

244

Naso pharyngeal carcinoma. Modalities of radiation therapy and combinations of radiotherapy and chemotherapy: state of art and perspectives; Les carcinomes du nasopharynx. Les modalites de la radiotherapie et les associations de la radiotherapie et de la chimiotherapie: etat actuel et perspectives  

Energy Technology Data Exchange (ETDEWEB)

Nasopharyngeal carcinoma (NPC) is a highly radiosensitive and chemo-sensitive. In the patient with locally advanced tumours, the results of conventional radiotherapy are unsatisfactory with significant rates of both local recurrences and distant metastases. The aim of this review is to report the innovative strategies for treatment of the nasopharyngeal carcinoma. Altered fractionation techniques can improve local control. The impact of the innovative techniques, including conformal radiation, stereotactic radiation and IMRT, on survival, must be evaluated in randomized trials. The encouraging early results obtained with concurrent (more than sequential) chemotherapy and radiotherapy must be confirmed in prospective randomized trial in endemic areas. (authors)

Daoud, J.; Frikha, M. [Centre Hospitalier Universitaire Habib Bourguiba, Sfax (Tunisia)

2001-11-01

245

Should the pulmonary scintigraphy of pre-surgery examination of bronchial carcinomas be made at rest or under effort?; La scintigraphie pulmonaire du bilan pre-operatoire des carcinomes bronchiques doit elle etre realisee au repos ou a l`effort?  

Energy Technology Data Exchange (ETDEWEB)

One of the key elements in deciding whether a patient, bearing a bronchial carcinoma, should be subject to a surgery is the predicted value of the post-surgery maximal exhaled volume per second (MEVS), usually determined by means of an at-rest pulmonary perfusion scintigraphy. At the same time, this parameter remains rather badly correlated to mortality and peri-surgical morbidity. The goal of this study was to determine whether under-effort pulmonary perfusion scintigraphy, i.e. in peri-surgical conditions gives different results in this case. Twenty patients bearing bronchial carcinoma have benefited by a pulmonary scintigraphy, successively, in the end of an exercise on ergo-metric bicycle and at rest. Two mCi of Tc-labelled macro-aggregate albumin were injected after effort, then 10 mCi one hour later, at rest. The homo-lateral lung perfusion to tumor, expresses in % of total pulmonary perfusion (% TP), was reduced at rest (-8 {+-} 6%) and at effort (-10 {+-} 8%), in comparison with the normal values. On the analysis of ensemble of population (43 {+-} 7% vs 41 {+-} 9%, NS) the % TP did not changed significantly between the at-rest and under-effort acquisitions. At the same time, 4 patients presented important variation, amounting up to 20% of total pulmonary perfusion: the % TP increased in 2 cases and decreased in the other 2 cases. In conclusion, in the patients bearing bronchial carcinoma, the relative perfusion of tumoral lung varies under effort in a non-negligible number of cases (4/20). Additional studies are necessary to establish the value of under-effort pulmonary scintigraphy, in the evaluation of the post-surgery respiratory functional capacity

David, N.; Olivier, P.; Arsena, T.; Quiri, N.; Hassan, N.; Haouzi, P.; Borelly, J.; Marie, P.Y.; Karcher, G.; Bertrand, A. [Service de Medecine Nucleaire, CHU - Nancy (France)

1997-12-31

246

Fluoro choline({sup 18}F) has a clinical usefulness in prostate cancer and in hepatocellular carcinoma sometimes in the same patient;La fluorocholine({sup 18}F) a une utilite clinique dans le cancer de la prostate et le carcinome hepatocellulaire parfois chez le meme malade  

Energy Technology Data Exchange (ETDEWEB)

Case report: In order to stage hepatocellular carcinoma (H.C.C.), a patient was referred to PET/CT using fluorodeoxyglucose({sup 18}F) (F.D.G.) and, if necessary, fluoro choline({sup 18}F) (F.C.H.). H.C.C. was proven by biopsy of a hepatic mass discovered on CT performed for a biological recurrence of prostate cancer. Result: F.D.G. PET/CT did not show any anomaly. F.C.H. PET/CT was thus performed and showed various foci: the hepatic mass, a large abdominal adenopathy and an unexpected sub centimeter lung nodule. The diagnostic uncertainty mostly concerned this lung nodule which was biopsied and consisted of a metastasis of the prostate cancer. Due to the presence of two metastatic cancers, the patient's management was altered, with chemotherapy for the H.C.C. and hormone therapy for the prostate cancer. Conclusion: Several types of cancer take-up fluoro choline({sup 18}F), which is a powerful tool to detect metastases, in particular in case of rising levels of marker with a negative F.D.G. PET/CT. Even when F.D.G. PET/CT is positive, F.C.H. may reveal unexpected foci with other metabolic characteristics, although it is not specific of a given primary cancer, as well as F.D.G.. For staging of H.C.C., we thus recommend to perform PET/CT with both tracers. (authors)

Balogova, S.; Kerrou, K.; Huchet, V.; Gutman, F.; Montravers, F.; Talbot, J.N. [Universite Pierre-et-Marie-Curie, Service de medecine nucleaire, hopital Tenon, AP-HP, 75 - Paris (France); Balogova, S. [Universite Comenius, Bratislava (Slovakia); Bumsel, F. [Universite Pierre-et-Marie-Curie, Service d' hepato-gastro-enterologie, hopital Saint-Antoine, AP-HP, 75 - Paris (France); Nataf, V. [Hopital Tenon, AP-HP, Radiopharmacie, 75 - Paris (France); Mal, F. [Institut mutualiste Montsouris, Departement de pathologie digestive, 75 - Paris (France)

2010-07-15

247

Combination of radiotherapy and cetuximab for patients suffering from of an advanced and non operable epidermoid carcinoma of the ORL sphere: results and side effects; Association de radiotherapie et de cetuximab chez des patients atteints d'un carcinome epidermoide de la sphere ORL evolue non operable: resultats et effets secondaires  

Energy Technology Data Exchange (ETDEWEB)

The authors report a retrospective survey of a set of locally advanced epidermoid carcinomas treated by irradiation and cetuximab. They assessed the response to the treatment, the specific survival, and the global survival as well as the tolerance. The survey is based on 31 men and 5 women suffering from different stage 4 non-metastatic advanced epidermoid carcinomas of the ORL sphere. Short communication

Acevedo, C.; Valette, G.; Bouchekoua, M.; Marianowski, R.; Pradier, O. [CHU Morvan, 29 - Brest (France)

2010-10-15

248

Total encephalic radiotherapy and concomitant administering of trastuzumab for brain metastases of a mammary carcinoma with HER2 overexpression: experience of the Curie Institute; Radiotherapie encephalique totale et administration concomitante de trastuzumab pour des metastases cerebrales d'un carcinome mammaire surexprimant HER2: experience de l'institut Curie  

Energy Technology Data Exchange (ETDEWEB)

The authors report a retrospective study of assessment of the tolerance to and of the activity of the trastuzumab in association with a total encephalic irradiation. The study is based on 31 patients suffering from brain metastases in relationship with a mammary cancer with HER2 expression, and who have been submitted to a total encephalic radiotherapy with a trastuzumab treatment. This medicine appears to be efficient and harmless. A clinic trial should confirm these results. Short communication

Chargari, C.; Idrissi, H.R.; Pierga, J.Y.; Bollet, M.; Dieras, V.; Campana, F.; Cottu, P.; Fourquet, A.; Kirova, Y. [Institut Curie, 75 - Paris (France)

2010-10-15

249

Thyroid medullary carcinoma and PET/CT with {sup 18}F-DOPA in the post surgery follow up: preliminary results; Carcinome medullaire de la thyroide et TEP/TDM a la {sup 18}F-DOPA dans le suivi post-chirurgical: resultats preliminaires  

Energy Technology Data Exchange (ETDEWEB)

Purpose: to study the contribution of the PET/CT with {sup 18}F DOPA in the therapy follow-up of patients with a history of medullary thyroid carcinoma and biological suspicion of residual disease or recurrence. Conclusions: The preliminary results show the interest of the PET/CT with {sup 18}F DOPA in the therapy follow-up and the management of patients suffering of medullary thyroid carcinoma in biological relapse. (N.C.)

Keomany, J.; Rust, E.; Constantinesco, A.; Imperiale, A. [CHU de Strasbourg, Service de biophysique et medecine nucleaire, 67 (France); Detour, J. [CHU de Strasbourg, Service de radiopharmacie, 67 (France); Chabrier, G.; Goichot, B. [CHU de Strasbourg, Service de medecine interne, endocrinologie et nutrition, 67 (France); Schneegans, O. [FNCLCC Paul-Strauss, 67 - Strasbourg (France)

2010-07-01

250

Thyroid medullar carcinoma and therapy follow up with the help of PET/T.D.M. with {sup 18}F-DOPA: about four cases; Carcinome medullaire de la thyroide et suivi therapeutique a l'aide de la TEP-TDM a la 18F-DOPA: a propos de quatre cas  

Energy Technology Data Exchange (ETDEWEB)

The objective was to study the contribution of the PET-T.D.M. to the dihydro phenylalanine labelled with {sup 18}F ({sup 18}F-DOPA) in the therapy follow up of patients with antecedents of thyroid medullar carcinomas and suspicion of biological recurrence. In spite of the very preliminary character of these results, these first cases show the interest of the PET-T.D.M. with {sup 18}F-DOPA in the therapy follow up and the coverage of patients reached by thyroid medullar carcinoma in biological recurrence. (N.C.)

Imperiale, A.; Ben-sellem, D.; Keomany, J.; Constantinesco, A. [Biophysique et medecine nucleaire, CHU de Strasbourg, (France); Detour, J.; Beretz, L. [radiopharmacie, CHU de Strasbourg, (France); Chabrier, G.; Goichot, B. [medecine interne et nutrition, CHU de Strasbourg, (France)

2009-05-15

251

Interest of the PET with F.D.G. in the evaluation of patients candidates to hepatic transplantation for hepatocellular carcinoma; Interet de la TEP au FDG dans l'evaluation des malades candidats a la transplantation hepatique pour carcinome hepatocellulaire  

Energy Technology Data Exchange (ETDEWEB)

Purpose: the objective of this study was to evaluate the interest of PET with F.D.G. as predictive factor of progression and output of liver transplant list for hepatocellular carcinoma. Conclusions: These preliminary data show that the positivity of PET with F.D.G. is strongly associated to a output of liver transplant list for tumor progression. (N.C.)

El Bez, I.; Hamza, F.; Yeddes, I.; Evangelista, E.; Meignan, M.; Itti, E. [CHU Henri-Mondor, Service de medecine nucleaire, 94 - Creteil (France); Decaens, T.; Duvoux, C. [CHU Henri-Mondor, Service d' hepato-gastroenterologie medecine nucleaire, 94 - Creteil (France); Luciani, A. [CHU Henri-Mondor, Service de radiologie, 94 - Creteil (France); Laurent, A. [CHU Henri-Mondor, Service de chirurgie digestive, 94 - Creteil (France)

2010-07-01

252

Feasibility of an early dynamic acquisition in PET-F.D.G. to evaluate the prognosis of epidermoid carcinomas of superior aero digestive pathways; Faisabilite d'une acquisition dynamique precoce en TEP-FDG pour l'evaluation pronostique des carcinomes epidermoides des VADS  

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purpose: evaluate the feasibility of an early dynamic acquisition in PET-F.D.G. in the staging of squamous cell carcinomas of upper aero digestive tract. Extract kinetics parameters of F.D.G. tumor uptake and compare them to SUV{sub max} at 60 minutes (prognosis value recognized but without established cut-off) and to {Delta}SUV{sub max} (1-2 h). Conclusions: The results of our study demonstrates the realisation feasibility of a early 60 minutes dynamic acquisition in PET-F.D.G. at the cervical level, allowing to get a kinetic parameter (initial slope) independent of the SUV{sub max} simple measure at 1 h and to envisage to compare their respective prognosis value in the initial evaluation of epidermoid carcinomas of superior aero digestive pathways. (N.C.)

Abgral, R.; Le Roux, P.Y.; Querellou, S.; Turzo, A.; Salaun, P.Y. [CHU de Brest, Service de medecine nucleaire, 29 (France); Valette, G.; Potard, G.; Marianowski, R. [CHU de Brest, Service d' oto-rhinolaryngologie, 29 (France); Conan-Charlet, V. [CHU de Brest, Service d' anatomopathologie, 29 (France); Moser, E. [Centre hospitalier de Quimper, service de radiotherapie, 29 (France)

2010-07-01

253

Impact of {sup 18}F-fluoro-deoxy-glucose positron emission tomography (F.D.G.-PET) in recurrent colorectal cancer; Evaluation de la TEP au {sup 18}F-F.D.G. dans l'exploration de la recidive des carcinomes colorectaux  

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Purpose The aim of the study was to evaluate the diagnostic performance, the prognosis factors and the therapeutic impact of {sup 18}F-F.D.G. positron emission tomography (F.D.G.-PET) in the detection of recurrent colorectal cancers. Methods Sixty PET/CT with {sup 18}F-F.D.G. and CT were performed in 52 patients, at the Paul Papin cancer center between 2003 and 2005, following suspicion of colorectal cancer relapse. The F.D.G.-PET impact on the clinical management was studied by examination of multidisciplinary consultations results. Survival analysis were realized with a mean follow up of 2.2 years. Results Recurrence was confirmed for 50 explorations by histologic (n = 32), radiologic (n = 14) or clinical (n = 4) findings. Twenty patients died during the time of the study. On a patient based analysis, F.D.G.-PET sensitivity, specificity and overall accuracy were 90, 90, 90% respectively compared with 74, 50 and 70% for CT. F.D.G.-PET changed the clinical management in 18 cases (30%). A positive F.D.G.-PET signal, more than one hepatic lesion, more than two lymph node lesions detected on F.D.G.-PET and more than two hepatic lesions on CT were characterized as bad prognostic factors for survival. Multivariate analysis showed that the only independent bad prognostic factor was the F.D.G.-PET detection of more than two liver lesions. Conclusion These results confirmed the important impact of F.D.G.-PET in the clinical management of patients with a suspected recurrence of colorectal cancer. (authors)

Metrard, G.; Morel, O.; Girault, S.; Soulie, P.; Guerin-Meyer, V.; Lorimier, G.; Gamelin, E. [Centre Paul-Papin, 49 - Angers (France); Metrard, G.; Jeanguillaume, C.; Berthelot, C.; Le Jeune, J.J. [Centre Hospitalier Universitaire, Service de Medecine Nucleaire, 49 - Angers (France); Parot-Schinkel, E. [Centre Hospitalier Universitaire, Service de Recherche Clinique, 49 - Angers (France)

2009-09-15

254

Diagnostic performances of the S.R.S. (scintigraphy of somatostatin receptors) and of the PET-F.D.G. in the extension situation of the well differentiated endocrine carcinomas at high Ki67; Performances diagnostiques de la SRS et de la TEP-FDG dans le bilan d'extension des carcinomes endocrines bien differencies a Ki67 eleve ({>=} 10%)  

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The results suggest that among 90% of patients with well differentiated endocrine carcinomas at high Ki, the PET-F.D.G. is more noticeable or equivalent to the scintigraphy of somatostatin receptors (S.R.S.). (N.C.)

Abgrala, R.; Leboulleux, S.; Deandreis, D.; Lumbroso, J.; Schlumberger, M.; Baudin, E. [Medecine nucleaire, institut Gustave-Roussy, Villejuif, (France); Auperin, A. [Biostatistiques, Institut Gustave-Roussy, Villejuif, (France); Dromain, C. [radiologie, institut Gustave-Roussy, Villejuif, (France); Guigay, J. [pneumologie, institut Gustave-Roussy, Villejuif, (France); Ducreux, M. [hepato-gastroenterologie, Institut Gustave-Roussy, Villejuif, (France)

2009-05-15

255

Synthèse et Evaluations Biologiques des Glyconanoparticules d'Or: Ligands pour Etudier l'Effet de Multivalence  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Les interactions des glucides sont impliquées dans plusieurs processus biologiques normaux ou bien pathologiques (la communication cellulaire, l'adhésion et l'entrée de pathogènes dans la cellule ou encore de carcinomes métastatiques). Souvent, ces interactions ont une forte spécificité mais une affinité faible. In vivo, cette faible affinité est résolue par la présentation de copies multiples des ligands glucidiques à des multiméres de récepteurs protéiques (lectines). Globale...

Reynolds, Michael

2009-01-01

256

Apport de la microscopie electronique dans la compréhension des mécanismes d'interactions entre nanoparticules et cellules biologiques  

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Parmi les nanoparticules aptes à accompagner la radiothérapie en clinique, les nanoparticules à base d'oxyde de gadolinium paraissent pertinentes, de part leur multimodalité en imagerie et leur effet radiosensibilisant prouvé in vitro et in vivo. Cet effet de radiosensibilisation est exceptionnel notamment sur des cellules cancéreuses radiorésistantes de la lignée SQ20B (carcinome squameux tête et cou) et uniquement pour des doses modérées de nanoparticules (aux alentours de 0.6 mM...

Rima, Wael

2012-01-01

257

Analyse de la méthylation de l'ADN des cellules CD133+ dans le cancer du foie et son interaction avec la voie de signalisation TGF-b  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Au sein des tumeurs, y compris pour le carcinome hépatocellulaire (CHC), des sous-populations de cellules néoplasiques ont révélé une grande capacité à initier de nouvelles tumeurs et à induire des métastases. Les premières études sur ces cellules ont rapidement montré que la présence de ces cellules était déterminante dans le développement tumoral et elles ont donc été renommées " cellules souches cancéreuses " (CSCs). Malheureusement les mécanismes impliqués dans la ma...

Martin, Marion

2013-01-01

258

Systemic amyloidosis and ovarian carcinoma.  

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A case of ovarian carcinoma and systemic amyloidosis in a 64 year old woman with nephrotic syndrome is reported. Immunohistochemical study of renal and rectal biopsy specimens revealed the presence of amyloidosis AA antigens, consistent with secondary amyloidosis. The absence of chronic inflammatory or infectious disease suggested the presence of a neoplasm. The gynaecological sonogram showed a solid mass located behind the uterus. Laparotomy confirmed a poorly differentiated ovarian carcinom...

Fernandez-miranda, C.; Mateo, S.; Gonzalez-gomez, C.; Ballestin, C.

1994-01-01

259

Stabilization of mismatch repair gene PMS2 by glycogen synthase kinase 3? is implicated in the treatment of cervical carcinoma  

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Abstract Background PMS2 expression loss was reported in a variety of human. However, its importance has not been fully understood in cervical carcinoma. The aim of this study was to determine the expression of PMS2 in cervical carcinoma and evaluate the significance of mismatch repair gene PMS2 regulated by glycogen synthase kinase 3? (GSK-3?) in chemosensitivity. Methods We examined PMS2 and phosphorylated GSK-3?(s9) expression in cervical carcinom...

2010-01-01

260

Reactive oxygen species, hepatitis and carcinogenesis initiation : an integrative approach combining transcriptomic and metabonomic profilings  

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Le stress oxydant et l’inflammation jouent un rôle important dans le développement du cancer. Les modèles animaux, comme le rat LEC, qui est muté sur un gène en relation avec l’excrétion hépatique du cuivre et qui développe spontanément une hépatite puis un carcinome hépatocellulaire, sont des outils intéressants pour comprendre la relation existant entre inflammation, stress oxydant et initiation du cancer. L’expression des gènes et les profils métaboliques des rats LEC ?...

Marquez-quinones, Adriana

2007-01-01

 
 
 
 
261

CA72-4 antigen levels in serum and peritoneal washing in gastric cancer: correlation with morphological aspects of neoplasia Níveis sérico e no lavado peritonial do antígeno CA 72-4 no câncer gástrico: correlação com aspectos morfológicos da neoplasia  

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BACKGROUND: Determining levels of tumor markers in peritoneal washing enables likelihood of peritoneal recurrence to be ascertained in patients with high marker levels, thereby allowing provision of more accurate adjuvant treatment and postoperative follow up. AIM: To analyze the relationship between levels of tumor marker CA72-4 in serum and peritoneal washing, and morphological aspects of gastric carcinoma. METHOD: This study analyzed 32 consecutively-operated patients with gastric carcinom...

2007-01-01

262

Use of in vitro assays to assess the potential antiproliferative and cytotoxic effects of saffron (Crocus sativus L.) in human lung cancer cell line  

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Background: Saffron is harvested from the dried, dark red stigmas of Crocus sativus flowers. It is used as a spice for flavoring and coloring food as a perfume. It is often used for treating several diseases. We investigated the potential of the ethanolic extract of saffron to induce antiproliferative and cytotoxic effects in cultured carcinomic human alveolar basal epithelial cells in comparison with non-malignant (L929) cells. Materials and Methods: Both cells were cult...

Samarghandian Saeed; Boskabady Mohammad; Davoodi Saideh

2010-01-01

263

Perturbation de la voie de signalisation du TGF-? par les protéines du virus de l'hépatite C , impact sur la carcinogenèse  

Digital Repository Infrastructure Vision for European Research (DRIVER)

L'infection chronique par le virus de l'hépatite C (VHC) conduit au développement de pathologies hépatiques, telles que la fibrose dont le terme évolutif est la cirrhose sur laquelle peut se développer un carcinome hépatocellulaire. Les observations cliniques indiquent que le VHC interfère avec la voie de signalisation du Transforming Growth Factor ? (TGF?). Entre autres fonctions, cette cytokine induit la transition épithélio-mésenchymateuse (EMT), ce qui favorise la migration ce...

2012-01-01

264

Potentialisation de la virothérapie anti-tumorale basée sur des adénovirus oncolytiques dans le traitement des cancers côliques et rénaux  

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Nous avons mis en place au cours de ce travail de thèse différentes stratégies permettant d'améliorer l'efficacité thérapeutique des adénovirus (Ad) oncolytiques contre différents types de tumeurs. Une première stratégie a été de combiner un inhibiteur d'histone-désacétylase, l'acide valproique (VPA) avec un Ad oncolytique à capside sauvage E1?24 (CRAd) dans le traitement de carcinomes côliques. Nous avons dans un premier temps démontré que la combinaison du CRAd et du VPA ...

2013-01-01

265

C16-Ceramide Analog Combined with Pc 4 Photodynamic Therapy Evokes Enhanced Total Ceramide Accumulation, Promotion of DEVDase Activation in the Absence of Apoptosis, and Augmented Overall Cell Killing  

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Because of the failure of single modality approaches, combination therapy for cancer treatment is a promising alternative. Sphingolipid analogs, with or without anticancer drugs, can improve tumor response. C16-pyridinium ceramide analog LCL30, was used in combination with photodynamic therapy (PDT), an anticancer treatment modality, to test the hypothesis that the combined treatment will trigger changes in the sphingolipid profile and promote cell death. Using SCCVII mouse squamous carcinom...

Separovic, Duska; Saad, Ziad H.; Edwin, Ethan A.; Bielawski, Jacek; Pierce, Jason S.; Buren, Eric; Bielawska, Alicja

2011-01-01

266

Usefulness of [{sup 18}F]-FDOPA PET as an adjunct to [{sup 18}F]-FDG PET in the imaging of small cell lung carcinoma. Preliminary results; La TEP a la [{sup 18}F]-FDOPA dans l'imagerie des carcinomes bronchiques a petites cellules: comparaison avec l'imagerie conventionnelle et la TEP au [{sup 18}F]-FDG. Resultats preliminaires  

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Small Cell Lung carcinomas (SCLC) are tumours which express neuroendocrine markers. Dihydroxy-phenylalanine (DOPA) is known to accumulate in neuroendocrine tumours. It looked interesting to assess the ({sup 18}F)-FDOPA uptake by SCLC and to assess the role of ({sup 18}F)-FDOPA PET in SCLC imaging. A ({sup 18}F)-FDG PET was performed in 7 patients affected with SCLC. An additional ({sup 18}F)-FDOPA PET was performed in 4 of these patients and compared with standard staging procedures. Among the 7 patients, 4 were referred for initial staging, 2 for a suspicion of recurrence and 1 for a suspicion of persistent disease. In the 4 patients with an additional ({sup 18}F)-FDOPA PET, there was an agreement between ({sup 18}F)-FDG PET and standard imaging procedures in 9 tumours sites out of 9. On the other hand there was no agreement between ({sup 18}F)-FDOPA PET and ({sup 18}F)-FDG PET in 6 tumour locations out of 9. In 3 of the 4 patients, a relationship was found between ({sup 18}F)-FDOPA PET and the expression of neuroendocrine tumour markers in immunohistochemistry (IHC) (Chromogranin A, Synaptophysine and NCAM). ({sup 18}F)-FDOPA PET appeared less sensitive than FDG PET and standard imaging procedures in the staging of small cell lung carcinoma. However, a relationship seemed to exist between positivity in IHC and ({sup 18}F)-FDOPA uptake, but this has to be assessed in larger series of patients. This relationship could have further applications in the search for a subgroup of SCLC patients with a better tumour differentiation and perhaps a better prognosis. (authors)

Jacob, T.; Grahek, D.; Kerrou, K.; Aide, N.; Montravers, F.; Younsi, N.; Balogova, S.; Beco, V. de; Colombet, C.; Talbot, J.N. [Hopital Tenon, Service de Medecine Nucleaire, et Centre TEP AP-HP, 75 - Paris (France)

2003-07-01

267

Tonsillectomy and Adenoidectomy  

Medline Plus

Full Text Available ... Eustachian tube The adenoids are located behind the soft palate. The soft palate is the back, muscular part of the ... It dangles down from the middle of the soft palate. Behind the uvula, there is a passageway ...

268

Snoring  

Medline Plus

Full Text Available ... caused by a variety of things. It's the soft tissues in the back of the mouth and ... it and they vibrate. It's the uvula, the soft palate, the tonsils, the adenoids and it is ...

269

Tonsillectomy and Adenoidectomy  

Medline Plus

Full Text Available ... infections or inflammation. This can sometimes lead to hearing loss. Symptoms & Causes The most common reason that a ... adenoids and clogged Eustachian tubes, can lead to hearing loss. Sometimes hearing loss can cause speech problems. An ...

270

Otitis Media  

Medline Plus

Full Text Available ... 3 years of life. There are three main reasons why children are more likely to suffer from ... the tonsils and adenoids may be appropriate for reasons other than clearing the middle ear fluid. Hearing ...

271

Oral Cancer Removal and Palate Reconstruction  

Medline Plus

Full Text Available ... Browne, professor of otolaryngology Head and neck surgery. Today, Dr. Browne is going to remove an adenoid ... type of cancer that we’re working on today, this cancer travels along nerves and has a ...

272

Otitis Media  

Medline Plus

Full Text Available ... to collect in the middle ear. Adenoids are special glands that help fight infections. They are located ... doctors recommend that a child with tubes wear special earplugs while swimming or bathing so that water ...

273

Oral Cancer Removal and Palate Reconstruction  

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Full Text Available ... zygomatic arch to fill the defect. 00:06:37 Often, adenoid cystic carcinoma, the type of cancer ... ll be sewing this in now. And… 00:37:36 Page 9 of 15 CHRISTOPHER A. SULLIVAN, ...

274

Sinus Tumors  

Science.gov (United States)

... scan of a patient with a sinus cancer (esthesioneuroblastoma) on the right side. Benign and malignant tumor ... adenoid cystic carcinoma, mucoepidermoid carcinoma, melanoma, olfactory neuroblastoma (esthesioneuroblastoma), sarcoma, and lymphoma. Malignant lesions from other body ...

275

Coblation Assisted Tonsillectomy  

Medline Plus

Full Text Available ... from tonsillectomy, these include inferior turbinate reduction, soft palate reduction, and uvulopalatoplasty. Let’s take a look at ... red tubes that we use to retract the palate to expose the adenoid tissue. At this point, ...

276

Tonsillectomy and Adenoidectomy  

Medline Plus

Full Text Available ... tube The adenoids are located behind the soft palate. The soft palate is the back, muscular part of the roof ... dangles down from the middle of the soft palate. Behind the uvula, there is a passageway that ...

277

Tonsillectomy and Adenoidectomy  

Medline Plus

Full Text Available ... middle ear infections or inflammation. This can sometimes lead to hearing loss. Symptoms & Causes The most common ... to swollen adenoids and clogged Eustachian tubes, can lead to hearing loss. Sometimes hearing loss can cause ...

278

Tonsillectomy and Adenoidectomy  

Medline Plus

Full Text Available ... Enlarged tonsils or adenoids can lead to difficulty breathing while sleeping. This condition is known as obstructive ... on the basis of: • A history of difficulty breathing while sleeping and • A physical exam that shows ...

279

What Are the Risk Factors for Thyroid Cancer?  

Science.gov (United States)

... fungus infections of the scalp (ringworm), or enlarged tonsils or adenoids. Years later, the people who had these treatments were found to have a higher risk of thyroid cancer. Radiation therapy in childhood for some cancers such ...

280

Types of Cancer Teens Get  

Science.gov (United States)

... cancer can be cured. Lymphoma Lymphoma refers to cancer that develops in the lymphatic system , which includes the lymph nodes, thymus, spleen, adenoids, tonsils, and bone marrow. The lymph system functions in ...

 
 
 
 
281

 

Medline Plus

Full Text Available ... Health South Florida, Miami, FL, 2/01/2012) Tonsils and Adenoids Coblation Assisted Tonsillectomy (Georgetown University Hospital, Washington, DC, 2/23/2004) Endocrine System Adrenal Gland Cancer Laparoscopic Adrenalectomy (Shawnee Mission Medical Center, Shawnee Mission, ...

282

Tonsillectomy and Adenoidectomy  

Medline Plus

Full Text Available ... sleeping. This condition is known as obstructive sleep apnea or OSA. Taking the tonsils and adenoids help ... bleeding too much. In cases of obstructive sleep apnea or OSA, the doctor is able to diagnose ...

283

Otitis Media  

Medline Plus

Full Text Available ... germs in the body. Eustachian tube Adenoids • A child's Eustachian tube is shorter and straighter than an ... the brain, and cause more severe complications. A child who has frequent ear infections could suffer from ...

284

Otitis Media  

Medline Plus

Full Text Available ... tube remains plugged, the fluid cannot drain and begins to collect in the middle ear. Adenoids are ... can also affect adults. Middle ear inflammation often begins when infections that cause sore throats, colds, or ...

285

Coblation Assisted Tonsillectomy  

Medline Plus

Full Text Available ... used for tamponading and a variety of tonsillar clamps are used, a curved tonsillar tenaculum or straight. ... I use to visualize the adenoids. These are clamps and red tubes that we use to retract ...

286

Otitis Media  

Medline Plus

Full Text Available ... for your specific condition. ©1995-2011, The Patient Education Institute, Inc. www.X-Plain.com ol190105 Last reviewed: 03/12/2011 3 • Adenoids in children are larger than they are in adults. Enlarged ...

287

Tonsillectomy and Adenoidectomy  

Science.gov (United States)

... condition is known as obstructive sleep apnea or OSA. Taking the tonsils and adenoids help relieve the obstruction and cure OSA. Diagnosis & Treatment Treatment of tonsillitis and ear infections ...

288

Tonsillectomy and Adenoidectomy  

Medline Plus

Full Text Available ... condition is known as obstructive sleep apnea or OSA. Taking the tonsils and adenoids help relieve the obstruction and cure OSA. Diagnosis & Treatment Treatment of tonsillitis and ear infections ...

289

Coblation Assisted Tonsillectomy  

Medline Plus

Full Text Available ... D. When you say obstruction, what is the relationship between obstruction and other childhood diseases? EARL HARLEY, ... adenoids. NORMAN SANDERS, M.D. Are your postoperative results similar for chronic tonsillitis versus hypertrophy? EARL HARLEY, ...

290

Asthma & Pregnancy  

Directory of Open Access Journals (Sweden)

Full Text Available Adenoid cystic carcinoma is a rare but distinctive salivary gland type malignant neoplasm that arises infrequently in the respiratory tract, where it is largely seen in the trachea or large airways. A 29-year-old female who presented with a peripheral lung mass due to pulmonary adenoid cystic carcinoma is reported in view of its unusual location, early age of presentation and lack of such reports in the recent literature.

Baruwa Pranab

2007-01-01

291

Lateral cephalometry: A simple and economical clinical guide for assessment of nasopharyngeal free airway space in mouth breathers  

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Nasopharyngeal obstruction by adenoid enlargement is one of the main causes of mouth breathing. Cephalometric radiographs and rhinomanometric tests to evaluate nasal obstruction have been available for several decades. Various lines and areas have been interpreted by number of investigators to implicate the enlarged adenoid in a casual relationship with mouth breathing and the subsequent effect on vertical facial growth. The aim of this paper is to review lateral cephalometric tracing methods...

Grewal, Navneet; Godhane, Alkesh V.

2010-01-01

292

[Verapamil enhancement of antitumor activity of mitoxantrone on ACC-22 cells in citro  

Science.gov (United States)

The combined effect of verapamil and DHAD on the growth of human adenoid cystic carcinoma cell line(ACC-2) in vitro was investigated.In combination, VP and DHAD had synergistic inhibitory effect.VP enhanced the cytotoxicity of DHAD in ACC-2 cells and significantly inhibited the cell proliferation.VP also potentiated the inhibitory effect of DHAD on colongenic ability of ACC-2 cell,suggesting it enhance the cytocidal effect of DHAD on human adenoid cystic carcinoma. PMID:15159875

Chen, J W; Qiu, W L; He, R G; Lin, G C

1993-03-01

293

Les kystes hydatiques du foie rompus dans les voies biliaires: ? propos de 120 cas  

Science.gov (United States)

Etude rétrospective rapportant une série de kystes hydatiques rompus dans les voies biliaires colligés dans le service de chirurgie de l'hôpital militaire Avicenne à Marrakech. Entre 1990 à 2008, sur 536 kystes hydatiques du foie opérés dans le service, 120 étaient compliqués de rupture dans les voies biliaires soit 22,38%. Il y avait 82hommes et 38 femmes. L’âge moyen était de 35 ans avec des extrêmes allant de 10 à 60 ans. La clinique était dominée par la crise d'angiocholite ou une douleur du flanc droit. L'ictère était isolé dans huit cas. La fistule biliokystique était latente dans plus de 50% des cas. Le traitement a consisté en une résection du dôme saillant dans103cas (85,84%), une périkystectomie chez 11 malades (9,16%) et une lobectomie gauche dans six cas (5%). Le traitement de la fistule bilio kystique a consisté en une suture chez 36malades et un drainage bipolaire dans 25 cas, La déconnexion kysto-biliaire ou cholédocotomie trans hépatico kystique selon Perdomo était pratiquée dans 49cas et une anastomose bilio-digestive cholédoco-duodénale dans 10 cas. La durée moyenne d'hospitalisation était de 20jours. Nous déplorons deux décès par choc septique et un troisième par encéphalopathie secondaire à une cirrhose biliaire. La morbidité était représentée par huit abcès sous phrénique, douze fistules biliaires prolongées et deux occlusions intestinales. Les kystes hydatiques rompus dans les voies biliaires représentent la complication la plus grave de cette pathologie bénigne. Le traitement repose sur des méthodes radicales qui sont d'une efficacité reconnue, mais de réalisation dangereuse et les méthodes conservatrices, en particulier la déconnexion kysto-biliaire qui est une méthode simple et qui donne de bons résultats à court et à long terme.

Moujahid, Mountassir; Tajdine, Mohamed Tarik

2011-01-01

294

Métastase splénique d'un adénocarcinome colique - à propos d'un cas et revue de la littérature  

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L'atteinte métastatique de la rate est rare et exceptionnellement isolée. En effet, elle survient généralement dans le cadre d'une atteinte multi viscérale. Les cancers les plus pourvoyeurs de métastase splénique sont les mélanomes, les carcinomes de l'ovaire, du sein et du poumon. Dans le cancer colique, l'atteinte métastatique isolée de la rate est rare, dix cas seulement ont été décrits dans la littérature jusque-là. À travers cette revue, nous décrivons un nouveau cas pr?...

El M Rabet, Fatima Zahra; Brahmi, Sami Aziz; Rachidi, Siham; Tizniti, Siham; Amaarti, Afaf; Ait Taleb, Khalid; El Mesbahi, Omar

2011-01-01

295

The association between atypical adenomatous hyperplasia and primary lung cancer  

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Atypical adenomatous hyperplasia (AAH) has been suggested as the adenoma in an adenoma–carcinoma sequence in the lung periphery. From 1989–1998, we undertook a systematic, prospective search for AAH in lungs resected for cancer. AAH was found in 67 of 554 patients (12.1%) with primary lung carcinoma (9.2% in male patients and 19.0% in females). AAH was found in lungs bearing adenocarcinoma (23.2%) more frequently than with large cell undifferentiated carcinoma (12.5%) or squamous carcinom...

Chapman, A. D.; Kerr, K. M.

2000-01-01

296

Parvovirus B19 outbreak on an adult ward.  

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In November and December 1992, an outbreak of parvovirus B19 infection occurred among patients and staff on an adult mixed surgical ward at a large hospital in London. Three patients and 15 staff members were serologically confirmed as acute cases. The attack rate among susceptible members of staff was 47%. In those infected, arthralgia (80%) and rash (67%) were the most common symptoms. Of six susceptible in-patients on the ward, three became infected. One of the in-patients who had carcinom...

1994-01-01

297

Osteolytic metastasis detected by F18-FDG PET in a patient with lung carcinoma  

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We present a 53-year-old man with a vocal cord paralysis observed as a primary manifestation of lung carcinoma. Tc-99m MDP whole body bone scan were performed and resulted a normal scintiscan. The bone scan does not revealed suspicious foci of uptake. The possibility of bone metastasis was taken into consideration. A whole body F18-FDG-PET scan showed intense uptake in the left upper lung corresponding to the primary tumor. A bronchial biopsy confirmed infiltration by small cell lung carcinom...

Gonza?lez Sistal, A?ngel; Baltasar Sa?nchez, Alicia; Sa?nchez Salmo?n, Aida; Ruibal Morell, A?lvaro

2013-01-01

298

Une tumeur rare et distincte du cancer du sein: le carcinosarcome, à propos de huit cas et revue de la littérature  

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Le carcinosarcome du sein souvent appelé carcinome métaplasique du sein, est une tumeur maligne rare composée de deux lignées cellulaires distinctes, il est décrit comme un cancer du sein de type canalaire avec un composant de type sarcome. Il représente 0,08-0.2% de toutes les tumeurs malignes du sein. Il s'agit d'une étude rétrospective étalée sur un an, huit cas des carcinosarcomes mammaires ont été colligés à l'Institut national d'oncologie au Maroc durant l'année 2007. La ...

Ghanem, Samia; Khoyaali, Siham; Naciri, Sara; Glaoui, Meriem; Mesmoudi, Mohamed; Errihani, Hassan

2013-01-01

299

Développements statistiques et algorithmiques pour l'analyse des cancers du sein de type triple négatif  

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Dans le monde, le cancer du sein est le cancer le plus fréquent de la femme. Plusieurs types de cancer du sein ont été mis en évidence. Les carcinomes infiltrants triple négatif (TNBC) sont l'un de ces types. Les TNBC sont parmi les plus agressifs cancers du sein et sont associés à un mauvais pronostique. Il n'y a pas encore de traitement dédié pour ces cancers. Cette thèse avait pour but d'identifier des gènes et des voies de signalisation dérégulés dans les cancers de types TN...

Rigaill, Guillem

2010-01-01

300

[Metastatic renal tumor from oral floor cancer: a case report].  

Science.gov (United States)

A 61-year-old man with oral floor cancer (adenoid cystic carcinoma, T2N0M1) was treated with systemicc hemotherapy and radiation therapy at the department of dentistry and oral surgery in our hospital. He had three lung metastases and renal tumors detected by screening computed tomography. The oral floor cancer responded to the treatment to achieve partial response. However, lung and renal metastases did not respond to chemotherapy. Then, the patient was referred to our clinic to rule out the possibility of lung metastasis from renal cell carcinoma. Laparoscopic left nephrectomy was performed and pathological examination on the renal lesions revealed adenoid cystic carcinoma, which had identical histopathological features to the oral floor cancer. To our knowledge, this is the first report of metastatic renal tumor from oral floor cancer (adenoid cystic carcinoma). PMID:23254785

Ishibashi, Yusuke; Hatakeyama, Shingo; Okamoto, Teppei; Suzuki, Yuichiro; Kudo, Shigemasa; Yoneyama, Takahiro; Koie, Takuya; Kamimura, Noritaka; Sakaki, Hirotaka; Kobayashi, Wataru; Kimura, Hiroto; Ohyama, Chikara

2012-11-01

 
 
 
 
301

The assessment of hypertrophy of nasopharyngeal tonsil by acoustical methods.  

Science.gov (United States)

The possibilities for using acoustical analysis as a noninvasive measure of the degree of obstruction created by an enlarged pharyngeal tonsil (adenoid) are discussed. The method capitalizes on the relationship which exists between a specific obstruction of the respiratory tract and the resulting respiratory sound. Results indicate that as the adenoid increases in size relative to the size of the nasopharynx, the dominant components of the respiratory sound spectrum shift towards a higher frequency range. Furthermore, the correlation found between the assessments of the obstruction due to various sizes of the adenoid by radiological methods and acoustical analyses supports the theoretical prediction that information on the size of the constriction is carried by the respiratory sound. Therefore, careful analyses of the acoustic patterns in the respiratory sound can assist in identifying constrictions and monitoring the constriction changes in the upper respiratory tract. PMID:8270362

Slawinski, E B; Dubanowicz-Kossowska, E

1993-10-01

302

Management of difficult airway in intratracheal tumor surgery  

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Abstract Background Tracheal malignancies are usual victim of delay in diagnosis by virtue of their symptoms resembling asthma. Sometimes delayed diagnosis may lead to almost total airway obstruction. For difficult airways, not leaving any possibility of manipulation into neck region or endoscopic intervention, femorofemoral cardiopulmonary bypass can be a promising approach. Case Presentation We are presenting a case of tracheal adenoid cystic carcinoma (cylind...

2005-01-01

303

Ultrastructural and immunocytochemical study of a case of invasive cribriform breast carcinoma.  

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A case of recurrent invasive cribriform carcinoma of the breast mimicked the histological and mucin staining characteristics of adenoid cystic carcinoma. The diagnosis was based on negative immunocytochemical staining for laminin and ultrastructural evidence of luminal differentiation by cells lining the cystic spaces. Accurate characterisation of this type of breast tumour can be facilitated by retrospective immunocytochemical or ultrastructural examination, or both.

Wells, C. A.; Ferguson, D. J.

1988-01-01

304

The diagnostic difficulties in tracheal neoplasms; Trudnosci diagnostyczne w nowotworach tchawicy  

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Since 1990-1992 in the Dept. of ENT Kalisz 5 patients with tracheal neoplasms were treated. On the base of this cases the diagnostic difficulties has been presented. A rare case of tracheal carcinoma adenoides treated by telecobaltotherapy was described. 6 years survival rate was observed. (author)

Bartnik, W.; Szewczyk, M.; Lomikowska, E.; Meler, M.; Rosolowska, J. [Wojewodzki Szpital Zespolony, Kalisz (Poland)

1994-12-31

305

Correlation Between Upper Airways Obstructive Indexes in Adenotonsilar Hypertrophy with Mean Pulmonary Arterial Pressure  

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Full Text Available Introduction: Hypertrophied tonsils and adenoids may cause upper airway obstruction and cardio-pulmonary complications due to pulmonary arterial hypertension. The aim of this study was to determine the correlation between mean pulmonary arterial pressure (mPAP and selected adenotonsilar hypertrophy indexes. Materials and Methods: Thirty two patients with upper-airway obstruction resulting from hypertrophied tonsils and adenoids were included in our study. Mean pulmonary arterial pressure was measured by a non-invasive method using color doppler echocardiography. Upper airway obstruction was evaluated by clinical OSA (obstructive sleep apnea scoring and also adenoidal-nasopharyngeal (A/N ratio in the lateral neck radiography. Results: Fifty percent of the patients with a normal OSA score, 20% of those with a suspected OSA score and also 50% of cases with OSA had pulmonary hypertension (mPAP>20mmHg which was not statistically significant  (P=0.198.  Mean Adenoidal-nasopharyngeal ratio in patients with a normal mPAP (mPAP?20mmHg was 0.61±0.048 and it was 0.75±0.09 in those with pulmonary hypertension; the difference was statistically significant (P=0.016. Conclusion: It seems that A/N ratio could be used as a predicting factor for increased mPAP in children with upper airway obstruction and a pediatric cardiologist consultation may be necessary before some surgical interventions.

Ehsan Khadivi

2010-07-01

306

Nephrin in human lymphoid tissues.  

Science.gov (United States)

When nephrin, the protein product of NPHS1, was cloned, it was proposed to be specific for the kidney glomerular podocytes. Recently, however, new reports have emerged verifying additional nephrin expression sites, particularly the insulin-producing beta cells of the pancreas, as well as the central nervous system. In this study, we demonstrate nephrin expression in lymphoid tissues, specifically the tonsil, adenoid and lymph node. Nephrin mRNA expression levels were 4-fold higher in tonsils and adenoids than in thymus or B lymphocytes, and 20-fold higher than in T lymphocytes or monocytes, as shown by quantitative RT-PCR analysis. Anti-nephrin antibodies recognised a specific 165-kDa band in lysates of tonsil and adenoid. In immunofluorescence and immunohistochemichal stainings of adenoid and lymph node sections, nephrin-positive cells were detected in the germinal centres of the lymphoid follicles in a staining pattern typical for interdigitating cells. These results indicate a definite and additional presence of nephrin in lymphoid tissue. PMID:16456616

Aström, E; Rinta-Valkama, J; Gylling, M; Ahola, H; Miettinen, A; Timonen, T; Holthöfer, H

2006-02-01

307

Lesiones benignas de mama que pueden simular un carcinoma en estudios imagenológicos / Benign breast lesions that mimic carcinoma in diagnostic imaging  

Scientific Electronic Library Online (English)

Full Text Available SciELO Argentina | Language: Spanish Abstract in spanish La mayoría de las lesiones que se encuentran al realizar estudios mamarios son benignas. Muchas de ellas tienen un aspecto típico y definido, ya sea en mamografía o ecografía y no requieren de evaluaciones adicionales. Existe un grupo de entidades benignas que, sin embargo, puede simular un carcinom [...] a en las imágenes. Los radiólogos debemos conocer las características de las mismas y tenerlas en cuenta como posibles diagnósticos diferenciales de una imagen de alta sospecha. Abstract in english Most of the lesions found during breast imaging exams are benign. Many of them have a typical and definite appearance on mammography and ultrasound, and require no further evaluation. However, some benign lesions cannot be differentiated from carcinomas, given their suspicious and less specific radi [...] ological features. Radiologists should be aware of the imaging characteristics of these lesions and include them in the differential diagnosis of a malignant-appearing finding.

Mariana, Castro Barba; María Paz, Cobos Bombardiere; Flavia, Sarquis; Griselda, Luna; Bárbara, Miller.

308

Compound for cancer imaging and therapy  

Energy Technology Data Exchange (ETDEWEB)

The present invention relates to compounds having affinity for certain cancer cells, e.g. lung carcinomas, colon carcinoms, malignant melanomas, neuroblastomas and pheochromocytomas. The compounds also bind with high specificity to cell surface receptors and can therefore be used for diagnostic imaging of any tissue having an abundance of cells with sigma receptors. The compounds are of a general formula wherein X is a radionuclide, R{sub 2} is -N(R{sub 3}){sub 2} or a 5 to 6 member nitrogen containing heterocyclic ring, optionally substituted with at least one alkyl group. Methods are provided for diagnostic imaging and for the detection and treatment of tumors containing the cancer cells described above. (author).

John, C.S.; Baumgold, J.; McAfee, J.G.; Moody, T.W.

1993-05-06

309

In vitro NMR spectroscopy of healthy, mastopathically modified and carcinomatous breast tissue samples correlated with histological findings  

International Nuclear Information System (INIS)

Of 57 patients with clinically suspected mamma carcinoma 121 samples were analysed by in vitro 1H-NMR spectroscopy at 300 MHz and correlated with histological data. Within the relevant spectral region between 2.7 and 4.1 ppm strong signals were observed from fat, (phosphoryl-) choline, (phospho-) creatine, and carnitine. Furthermore, with high regularity, 8 weak, partly overlapping signals were resolved and attributed to glucose, glycine, threonine, serine, inositol, and sucrose. Their intensities were determined by an iterative fitness program. From the intensity ratios, different kinds of tissue could be distinguished based on spectroscopic criteria. Healthy or mastopathically modified tissue could be discriminated from more than 50% carcinomally affected tissue with a specificity of better than 99.5%. This fact is explained by the lower content of fatty acids in the malignant tissue. Differences between spectra of healthy of mastopathically affected tissue were only small. (orig.)

1994-08-01

310

Fast neutron radiotherapy for advanced malignant tumors of the paranasal sinuses  

International Nuclear Information System (INIS)

The radiotherapy of advanced and low grade tumors of the internal nose and paranasal sinuses is still a problem. The results of neutron therapy of 20 patients with advanced and low grade tumors are presented. These patients were treated between July 1977 and October 1988. The mean age of patients is 53 years. Ten patients had adenoid cystic carcinomas, three patients squamous cell carcinomas, one patient a mucinous cell carcinoma, two patients a low grade adenocarcinoma and four patients low grade sarcomas. Mean follow-up is 16 months. Local control could be achieved in eleven cases. The results show that adenoid cystic carcinomas, low grade adenocarcinomas and sarcomas benefit from neutron therapy. (orig.)

1990-01-01

311

Coblation adenoidectomy our experience  

Directory of Open Access Journals (Sweden)

Full Text Available Aim of our study is to compare the efficacy and safety of coblation adenoidectomy versus conventional cold steel adenoidectomy. The study design included 40 children between age groups 4 – 8. Twenty of these children underwent coblation adenoidectomy while the other group of 20 underwent conventional cold steel adenoidectomy. The parameters taken into consideration for comparison included Post operative pain, operating time, intraoperative bleeding and presence of residual adenoid tissue 6 weeks after surgery. In this study the coblation group demonstrated less post operative pain, less intraoperative bleeding and more complete removal of adenoid tissue. Operative time was found to be significantly higher in coblation group when compared to conventional cold steel adenoidectomy group.

Balasubramanian Thiagarajan

2014-03-01

312

Oral epithelial cells are susceptible to cell-free and cell-associated HIV-1 infection in vitro  

International Nuclear Information System (INIS)

Epithelial cells lining the oral cavity are exposed to HIV-1 through breast-feeding and oral-genital contact. Genital secretions and breast milk of HIV-1-infected subjects contain both cell-free and cell-associated virus. To determine if oral epithelial cells can be infected with HIV-1 we exposed gingival keratinocytes and adenoid epithelial cells to cell-free virus and HIV-1-infected peripheral blood mononuclear cells and monocytes. Using primary isolates we determined that gingival keratinocytes are susceptible to HIV-1 infection via cell-free CD4-independent infection only. R5 but not X4 viral strains were capable of infecting the keratinocytes. Further, infected cells were able to release infectious virus. In addition, primary epithelial cells isolated from adenoids were also susceptible to infection; both cell-free and cell-associated virus infected these cells. These data have potential implications in the transmission of HIV-1 in the oral cavity

2003-09-01

313

Carinal resection requiring cardiopulmonary bypass in a pregnant patient.  

Science.gov (United States)

A 35-year-old woman at 13 weeks gestation presented with adenoid cystic carcinoma of the distal left mainstem bronchus with chronic collapse of the left lung requiring carinal pneumonectomy. The extent of the tumor and need for significant retraction during dissection and pneumonectomy resulted in the need for cardiopulmonary bypass. The patient underwent successful left carinal pneumonectomy and subsequently delivered a healthy baby. PMID:23992710

Fitzsimons, Michael G; Ng, Joshua; Wright, Cameron; Mathisen, Douglas; Vlahakes, Gus; Albrecht, Meredith

2013-09-01

314

A histopathological study of lung cancer and other pulmonary malignant tumors in people exposed to the atomic bomb and non-exposed people in Hiroshima Pref  

International Nuclear Information System (INIS)

During cancer is likely to be more prevalent among A-bomb survivors based on epidemiological statistics. The histopathological classification of lung cancer was studied in 238 cases (57 exposed and 181 non-exposed) with onset in a period 1973 - 1977. None of the exposed patients had carcinoid, adenoid cystic carcinoma or mucoepidermoid carcinoma probably originating in the bronchial gland. Most of the exposed patients were slightly older than the non-exposed. Adenocarcinoma was more frequent among the exposed. (Chiba, N.)

1983-01-01

315

Cholesteatoma in a child with congenital ichthyosiform erythroderma.  

Science.gov (United States)

A 7-year-old girl had non-bullous congenital ichthyosiform erythroderma (NBCIE) in treatment with retinoids. She also suffered continuous desquamation of the external ears, recurrent external otitis, chronic adenoiditis, tubaric dysfunction and intermittent episodes of otitis media and developed a cholesteatoma in her left ear. Chronic scaling disorders, such as NBCIE and other ichthyosis, can be entities at risk for the development of cholesteatoma in childhood. PMID:10428408

Bartolomé, M; Torrelo, A; Molina, E; Zambrano, A

1999-06-15

316

Regulation of Production of Mucosal Antibody to Pneumococcal Protein Antigens by T-Cell-Derived Gamma Interferon and Interleukin-10 in Children  

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Nasopharyngeal tonsils (adenoids) are part of human nasopharynx-associated lymphoid tissue, which may play an important role in local defense against pneumococci. Recent studies with animals have suggested that several pneumococcal proteins, including CbpA and pneumolysin (Ply), may be vaccine candidates. Our recent data obtained with children suggest that antibodies to these proteins may protect against carriage. This study was performed to investigate the regulation of the T-cell-dependent ...

Zhang, Q.; Bernatoniene, J.; Bagrade, L.; Paton, J. C.; Mitchell, T. J.; Hammerschmidt, S.; Nunez, D. A.; Finn, A.

2006-01-01

317

Pleomorphic Adenoma in the Infra-temporal Space: The First Case Report  

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The infratemporal fossa is a deep retromaxillary space corresponding to the inferior aspect of the middle cranial fossa. Tumours in the infratemporal fossa are very rare; therefore experience in their diagnosis and therapeutic management is very limited. Tumors that are reported commonly in the infratemporal region are nasopharyngeal carcinomas, juvenile angiofibromas and adenoid cystic carcinomas. To the best of our knowledge, this is the first report in the English language literature of a ...

2007-01-01

318

PCR-Based Detection, Restriction Endonuclease Analysis, and Transcription of tonB in Haemophilus influenzae and Haemophilus parainfluenzae Isolates Obtained from Children Undergoing Tonsillectomy and Adenoidectomy  

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We developed and evaluated a PCR-based-restriction endonuclease analysis method to detect and analyze the tonB gene of Haemophilus influenzae and Haemophilus parainfluenzae from pediatric patients undergoing tonsillectomy and adenoidectomy. Multiple sites from the same patient, including the surface of adenoids and tonsils, as well as the core of tonsils, were cultured on chocolate agar and identified using standard procedures and the API NH Kit. A total of 55 H. influenzae isolates were reco...

Matar, Ghassan M.; Chahwan, Richard; Fuleihan, Nabil; Uwaydah, Marwan; Hadi, Usamah

2001-01-01

319

What Is the Role of Chlamydia pneumonia in Rhinosinusiits of Children?  

Directory of Open Access Journals (Sweden)

Full Text Available Chlamydia pneumoniae is a common respiratory pathogen which is often found in our paediatric populations. Many patients with community-acquired pneumonia caused by C. pneumoniae have symptoms suggestive of sinusitis.the role of C. pneumonia in rhinosinusiits children (Meanage =4.3 ±2.5year. This case control study was done in the pediatric and ENT clinics of Hazrat Rasul Hospital in Tehran (2004-2005. This study based on diagnostic parametersfor rhinosinusitis cases and controls .Serum Specific antibodies (IgG & IgM against Chlamydia. Pneumonia detected in 51 cases and 31 controls. Nasopharyngeal swabsfor detection the Chlamydia.p -DNA by PCR used in all cases and controls. Acute infection (IgM obtained in 11%(6/51; previous immunity (IgG in none(0/51 of rhinosinusitis cases.Acute infection (IgM detected in 6.5% (2/31;previous immunity (IgG in 13.3%(4/31 of controls and dependent to age (P=000. Acute infection(IgMhad not significant difference (P= 0.7 between cases and controls but previous infection(IgG was significantly higher in controls (0.007.Active infection(DNA- PCR not obatained in cases . Acute infection (IgMin cases was twice higher than controls.None of cases had previous immunity to chlamydial infection (IgG. It was significantly lower thanhealthy controls (P =0.01. These serological results had different results in compare with its role in pneumonia study but it was closer to adenoid study (16%. Adenoid may act as a reservoir for bacteria causing sinusitis, lung and chronic ear infection.We recommend specific antibiotics for C. pneumonia in resistant sinusitis to usual drugs especially in cases accordance with adenoiditis and adenoid hypertrophy before surgery.

2009-10-01

320

Epithelial-myoepithelial tumour of the lung: a case report referring to its molecular histogenesis  

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Abstract Tracheobronchial submucous glands can be considered the pulmonary equivalent of minor salivary glands and therefore they can develop most of the tumours originated in these. Nevertheless, in spite of the wide distribution of this kind of glands along the tracheobronchial tree, pulmonary salivary gland-like neoplasms are not very frequent. Among them, the most frequent are mucoepidermoid and adenoid cystic carcinomas. On the contrary, pulmonary neoplasms showing a mixture of...

Muñoz Guillermo; Felipo Francesc; Marquina Isabel; Agua Celia

2011-01-01

 
 
 
 
321

Epithelial-myoepithelial tumour of the lung: a case report referring to its molecular histogenesis  

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Tracheobronchial submucous glands can be considered the pulmonary equivalent of minor salivary glands and therefore they can develop most of the tumours originated in these. Nevertheless, in spite of the wide distribution of this kind of glands along the tracheobronchial tree, pulmonary salivary gland-like neoplasms are not very frequent. Among them, the most frequent are mucoepidermoid and adenoid cystic carcinomas. On the contrary, pulmonary neoplasms showing a mixture of epithelial and myo...

Mun?oz, Guillermo; Felipo, Francesc; Marquina, Isabel; Agua, Celia Del

2011-01-01

322

Structural and Immunological Characteristics of Chronically Inflamed Adenotonsillar Tissue in Childhood  

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Recurrent or chronic adenotonsillar infections mainly affect children and frequently involve otherwise healthy subjects. Therefore, having excluded systemic immunological deficiencies, this disease may be due to a local dysfunction of the epithelial structures at either the rhino or oropharyngeal level. The aim of the present investigation was to analyze structural and immunological aspects of tonsils and adenoids in subjects who underwent adenotonsillectomy because of recurrent inflammatory ...

Passa?li, Desiderio; Damiani, Valerio; Passa?li, Giulio Cesare; Passa?li, Francesco Maria; Boccazzi, Antonio; Bellussi, Luisa

2004-01-01

323

Leukotriene Modifier Therapy for Mild Sleep-disordered Breathing in Children  

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Background: Children with mild sleep-disordered breathing (SDB), who may not be recommended for adenotonsillectomy, frequently exhibit neurocognitive and behavioral morbidity, and may benefit from alternative therapeutic interventions, such as leukotriene modifier therapy. Methods: Twenty-four children with SDB completed an open-label intervention study for 16 weeks with daily montelukast therapy. Sleep studies and adenoid size estimates from lateral X-ray films of the neck were obtained befo...

Goldbart, Aviv D.; Goldman, Julie L.; Veling, Maria C.; Gozal, David

2005-01-01

324

Imaging of nasopharyngeal cysts and bursae  

International Nuclear Information System (INIS)

Cysts and bursae of the nasopharynx are uncommon and seldom symptomatic when compared with malignant tumors of this region. However, it is noteworthy that in the presence of symptoms, a good knowledge of their radiological appearance is useful to establish the correct diagnosis. Cysts of Rathke's pouch, pharyngeal bursa of Luschka, Tornwaldt's cysts, retentional cysts of the seromucinous glands, oncocytic cysts, intra-adenoid cysts, branchial cysts, prevertebral or retropharyngeal abscess and pseudocysts of the nasopharynx will be discussed in this paper. (orig.)

2006-10-01

325

Paediatric adenoidectomy: endoscopic coblation technique compared to cold curettage  

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The aim of our study was to assess the efficacy and safety of endoscopic coblator adenoidectomy compared to cold curettage in paediatric patients. Forty homogeneous children (4-16 years of age) with adenoid hypertrophy were divided in 2 groups to receive adenoidectomy using cold curettage (A) or coblator (B). After surgery the following outcomes were evaluated: pain score on first day, days reporting pain, analgesic days, liquid diet days, absent from school days, pain score, days with nausea...

Di Rienzo Businco, L.; Angelone, A. M.; Mattei, A.; Ventura, L.; Lauriello, M.

2012-01-01

326

Ten years of fast neutron therapy in Munster  

International Nuclear Information System (INIS)

The indication for neutron therapy in the treatment of malignant tumors is often uncertain. We therefore would like to present our experience of neutron therapy for different tumors in different localizations and discuss the indications for radiotherapy with neutrons. In Muenster, 269 patients were treated with neutrons between 1985 and 1995, via a deuterium-tritium generator with an energy of 14 Me V. The tumors, treated mainly with neutrons, were 64 adenoid cystic carcinomas of the salivary glands, 42 soft tissue sarcomas, 37 rectal cancer recurrences and 20 recurrences in the head and neck region. Furthermore, patients with non adenoid cystic carcinomas of the salivary glands as well as ten other tumor sites also received this treatment, mainly with palliative intent. The 64 patients with adenoid cystic salivary gland tumors had either an unresectable primary tumor, an unresectable recurrence of residual tumor (R1, R2) after surgery. These patients showed complete remission in 78 % and partial remission in 22 %. The 2-year survival rate was 76 %. Forty-two patients with soft tissue sarcomas after resection (R1, R2) and different grading had an overall survival rate after 5 years of 53 %. The 37 patients with rectal recurrence experienced rapid pain relief in nearly 90 % of cases. In agreement with the results in the literature, there seems to be an indication for neutron therapy in cases of unresectable primaries, unresectable recurrences or residual tumor after surgery in adenoid cystic carcinomas. Results regarding soft tissue sarcoma treatment with neutrons seem to show superiority in comparison with photon therapy. The treatment with neutrons of rectal recurrences has a very palliative effect. The radiotherapy treatment with neutrons in all the other tumors did not demonstrate any proven superiority in comparison with photon radiation. (author)

1995-05-04

327

Immunohistochemical characterisation of extracellular matrix components of salivary gland tumours.  

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Proteoglycans (PGs) were localised immunohistochemically in 52 salivary gland tumours including pleomorphic adenoma, adenoid cystic carcinoma, acinic cell carcinoma, oncocytoma, mucoepidermoid carcinoma, clear cell tumour and Warthin tumour, using antibodies raised against large PG, small PG, chondroitin 4-sulphate PG, chondroitin 6-sulphate PG, heparan sulphate PG and keratan sulphate PG. Large PGs were mainly observed in mucinous materials of extracellular matrix (ECM) and interstitial fibr...

Nara, Y.; Takeuchi, J.; Yoshida, K.; Fukatsu, T.; Nagasaka, T.; Kawaguchi, T.; Meng, N.; Kikuchi, H.; Nakashima, N.

1991-01-01

328

Sleep Endoscopy in the Evaluation of Pediatric Obstructive Sleep Apnea  

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Pediatric obstructive sleep apnea (OSA) is not always resolved or improved with adenotonsillectomy. Persistent or complex cases of pediatric OSA may be due to sites of obstruction in the airway other than the tonsils and adenoids. Identifying these areas in the past has been problematic, and therefore, therapy for OSA in children who have failed adenotonsillectomy has often been unsatisfactory. Sleep endoscopy is a technique that can enable the surgeon to determine the level of obstruction in...

Lin, Aaron C.; Koltai, Peter J.

2012-01-01

329

Characteristic karyotypic features in lacrimal and salivary gland carcinomas.  

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Short-term cultures from 12 non-squamous cell carcinomas (NSCCs) of the head and neck were cytogenetically investigated. Three tumours were acinic cell carcinomas, two adenoid cystic carcinomas, three mucoepidermoid carcinomas, two carcinomas in pleomorphic adenoma, and two adenocarcinomas. Clonal chromosome aberrations were detected in all but one adenocarcinoma. Including our data, a total of 40 head and neck NSCCs with clonal aberrations have been described. Deletions of the long arm of ch...

Jin, Y.; Mertens, F.; Limon, J.; Mandahl, N.; Wennerberg, J.; Dictor, M.; Heim, S.; Mitelman, F.

1994-01-01

330

Resection and reconstruction of the carina  

International Nuclear Information System (INIS)

We report the case of a 45 year old woman who presented with dyspnoea and cough since two years ago, the bronchoscopy showed a neoplastic lesion in the distal trachea affecting the carina, the histopathologic study confirmed an adenoid cystic carcinoma, we describe the preoperatory evaluation, the anesthetic procedures, and the surgical techniques used to resects and reconstruct the carina, this is the first case published in the national literature about the resection and reconstruction of the carina

1997-12-01

331

Mucocèle appendiculaire : à propos d’un cas observé à Lubumbashi  

Directory of Open Access Journals (Sweden)

Full Text Available RESUMELa mucocèle appendiculaire est une entité pathologique rare, mais potentiellement dangereuse ; elle se présente sous différentes formes cliniques. Nous rapportons ici un cas d'une patiente âgée de 49 ans sans antécédents chirurgicaux chez qui nous avons découvert d’une façon fortuite cette affection. La clinique était celle d’un syndrome appendiculaire aigu patent et elle révélait une masse dans la fosse iliaque droite. Les examens de laboratoire ont montré une hyperleucocytose et une vitesse de sédimentation augmentée. L'échographie a démontré une masse kystique péricaecal. La patiente a subi une appendicectomie avec cæcectomie partielle et la pièce opératoire appendiculaire mesurait 153 mm de longueur et 64 mm de diamètre. L’analyse anatomopathologique de celle-ci a confirmé le diagnostic de mucocèle appendiculaire sans cellules de malignité. Les suites opératoires ont été simples et la patiente est sortie au cinquième jour postopératoire. Mots-clés : Mucocèle appendiculaire Tumeur muco-sécrétant appendiculaire ; Appendicite ; LubumbashiSummary The appendiceal mucocele is a rare, but potentially dangerous pathological entity which presents in various clinical forms. We report here a case of a 49-year-old female patient without surgical history to whom we fortuitously discovered this affection. She came with clinical signs of an acute appendicitis and revealed a mass in the right iliac fossa. The examinations of laboratory showed an increase of white cells and of erythrocytes sedimentation rate. The ultrasound revealed a fluid pericaecal mass. The patient underwent an appendectomy with partial cæcectomy. The removed appendix measured 153 mm in length over 64 mm. The pathology confirmed the diagnosis and ruled out a malignant process. The postoperative went well and the patient was discharged on the fifth post-operative day.

KIPILI A

2013-01-01

332

Maspin and MCM2 immunoprofiling in salivary gland carcinomas  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background The pathogenesis of salivary gland carcinomas is very complex and prognostic markers are difficult to find in these carcinomas of which the different subtypes have varying malignant potential. The study was conducted to examine the cellular distribution of maspin and MCM2 in salivary gland carcinomas and their value to predict lymph node metastasis. Materials and methods Fifty three paraffin blocks of different lesions (15 muco-epidermoid carcinoma, 14 adenoid cystic carcinoma, 3 epi-myoepithelial carcinoma, 5 salivary duct carcinoma, 5 malignant pleomorphic adenoma, 6 polymorphous low grade adenocarcinoma and 5 acinic cell carcinoma were prepared for immunohistochemical staining with maspin and MCM2 antibodies. ANOVA and Pearson correlation tests were used for the statistical analysis of the results. Results All salivary gland carcinomas express maspin and MCM2 with variable cellular localization. There was a significant difference in the expression of each antibody between mucoepidermoid carcinoma, adenoid cystic carcinoma and polymorphous low grade adenocarcinoma. No association was found between examined markers and lymph node metastasis. Conclusions Salivary gland carcinomas express maspin and MCM2 with variable levels and cellular localization, consisting important markers of biological behavior in these tumors. The level of MCM2 expression can be used in the differential diagnosis of adenoid cystic carcinoma and polymorphous low grade adenocarcinoma. Further study with large sample size is recommended to assess their value in prediction of lymph node metastasis.

Helmy Iman M

2011-09-01

333

Radiation therapy for carcinoma of the major salivary glands  

International Nuclear Information System (INIS)

From January 1967 through November 1991, a total of 135 patients with carcinoma of the major salivary glands (parotid: 95; submandibular: 39, sublingual: 1) were treated at our department. 40 patients had adenocarcinoma, 29 adenoid cystic carcinoma, 24 mucoepidermoid carcinoma and 16 squamous cell carcinoma. 100 patients were irradiated postoperatively and the remaining 35 were treated with radiation alone. Total radiation doses delivered were 50 Gy for the postoperative group and 50 to 66 Gy for the group receiving only radiation using a 60Co single portal with or without wedged paired or single electron portal boost. Actuarial five-year survivals after radiation therapy were 55% for the postoperative group and 26% for radiation only group (p=0.0004). The local control rates for the postoperative group were 83% for adenocarcinoma, 81% for adenoid cystic carcinoma, 83% for mucoepidermoid carcinoma and 62% for squamous cell carcinoma. Corresponding figures for the radiation only group were 40% for adenocarcinoma, 38% for adenoid cystic carcinoma and 33% for mucoepidermoid carcinoma. Conventional irradiation techniques continue to play an important role because they offer superior local control for postoperative patients with carcinoma of the major salivary glands. However, the local control rates for the radiation only group were only 30 to 40%, so that new irradiation modalities such as provided by a high LET machine are needed for these patients. (orig.)

1993-08-01

334

Evaluation of Ga-67 scintigraphy for salivary gland tumors  

Energy Technology Data Exchange (ETDEWEB)

It is often difficult to exactly grasp the malignancy of salivary gland tumor because of inadaptability of percutaneous biopsy. The purpose of this study is to discuss whether Ga-67 scintigraphy on patient with salivary gland tumor can provide useful information for differential diagnosis. We studied retrospectivelly the case records of twenty patients with parotid or submandibular gland tumors admitted to the Nippon Dental University, School of Dentistry at Niigata, between January 1984 and December 1991. The final diagnoses of these twenty patients were pleomorphic adenoma in 11, adenocarcinoma in 3, adenoid cystic carcinoma in 3, Warthin's tumor in 1, oncocytoma in 1, and carcinoma in pleomorphic adenoma in 1. The scintigraphic patterns of the twenty patients were classified as negative (-), weakly positive (+), moderate positive (++), strongly positive (+++). Malignant tumors showed increased activity in Ga-67 images except those in three patients with adenoid cystic carcinomas. We concluded that Ga-67 scintigraphy may be useful to distinguish benign salivary gland tumors from adenocarcinoma or carcinoma in pleomorphic adenoma, but not be useful in detection of adenoid cystic carcinoma. (author).

Takase, Hiroshi; Toyama, Michio; Eguchi, Tooru; Maeda, Kadzuo (Nippon Dental Univ., Niigata (Japan))

1993-09-01

335

Evaluation of Ga-67 scintigraphy for salivary gland tumors  

International Nuclear Information System (INIS)

It is often difficult to exactly grasp the malignancy of salivary gland tumor because of inadaptability of percutaneous biopsy. The purpose of this study is to discuss whether Ga-67 scintigraphy on patient with salivary gland tumor can provide useful information for differential diagnosis. We studied retrospectivelly the case records of twenty patients with parotid or submandibular gland tumors admitted to the Nippon Dental University, School of Dentistry at Niigata, between January 1984 and December 1991. The final diagnoses of these twenty patients were pleomorphic adenoma in 11, adenocarcinoma in 3, adenoid cystic carcinoma in 3, Warthin's tumor in 1, oncocytoma in 1, and carcinoma in pleomorphic adenoma in 1. The scintigraphic patterns of the twenty patients were classified as negative (-), weakly positive (+), moderate positive (++), strongly positive (+++). Malignant tumors showed increased activity in Ga-67 images except those in three patients with adenoid cystic carcinomas. We concluded that Ga-67 scintigraphy may be useful to distinguish benign salivary gland tumors from adenocarcinoma or carcinoma in pleomorphic adenoma, but not be useful in detection of adenoid cystic carcinoma. (author)

1993-09-01

336

Transoral Robotic Surgery in Treating Patients With Benign or Stage I-IV Head and Neck Cancer  

Science.gov (United States)

Recurrent Adenoid Cystic Carcinoma of the Oral Cavity; Recurrent Lymphoepithelioma of the Nasopharynx; Recurrent Lymphoepithelioma of the Oropharynx; Recurrent Mucoepidermoid Carcinoma of the Oral Cavity; Recurrent Squamous Cell Carcinoma of the Hypopharynx; Recurrent Squamous Cell Carcinoma of the Larynx; Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity; Recurrent Squamous Cell Carcinoma of the Nasopharynx; Recurrent Squamous Cell Carcinoma of the Oropharynx; Recurrent Verrucous Carcinoma of the Larynx; Recurrent Verrucous Carcinoma of the Oral Cavity; Stage I Adenoid Cystic Carcinoma of the Oral Cavity; Stage I Lymphoepithelioma of the Nasopharynx; Stage I Lymphoepithelioma of the Oropharynx; Stage I Mucoepidermoid Carcinoma of the Oral Cavity; Stage I Squamous Cell Carcinoma of the Hypopharynx; Stage I Squamous Cell Carcinoma of the Larynx; Stage I Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage I Squamous Cell Carcinoma of the Nasopharynx; Stage I Squamous Cell Carcinoma of the Oropharynx; Stage I Verrucous Carcinoma of the Larynx; Stage I Verrucous Carcinoma of the Oral Cavity; Stage II Adenoid Cystic Carcinoma of the Oral Cavity; Stage II Lymphoepithelioma of the Nasopharynx; Stage II Lymphoepithelioma of the Oropharynx; Stage II Mucoepidermoid Carcinoma of the Oral Cavity; Stage II Squamous Cell Carcinoma of the Hypopharynx; Stage II Squamous Cell Carcinoma of the Larynx; Stage II Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage II Squamous Cell Carcinoma of the Nasopharynx; Stage II Squamous Cell Carcinoma of the Oropharynx; Stage II Verrucous Carcinoma of the Larynx; Stage II Verrucous Carcinoma of the Oral Cavity; Stage III Adenoid Cystic Carcinoma of the Oral Cavity; Stage III Lymphoepithelioma of the Nasopharynx; Stage III Lymphoepithelioma of the Oropharynx; Stage III Mucoepidermoid Carcinoma of the Oral Cavity; Stage III Squamous Cell Carcinoma of the Hypopharynx; Stage III Squamous Cell Carcinoma of the Larynx; Stage III Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage III Squamous Cell Carcinoma of the Nasopharynx; Stage III Squamous Cell Carcinoma of the Oropharynx; Stage III Verrucous Carcinoma of the Larynx; Stage III Verrucous Carcinoma of the Oral Cavity; Stage IV Adenoid Cystic Carcinoma of the Oral Cavity; Stage IV Lymphoepithelioma of the Nasopharynx; Stage IV Lymphoepithelioma of the Oropharynx; Stage IV Mucoepidermoid Carcinoma of the Oral Cavity; Stage IV Squamous Cell Carcinoma of the Hypopharynx; Stage IV Squamous Cell Carcinoma of the Larynx; Stage IV Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage IV Squamous Cell Carcinoma of the Nasopharynx; Stage IV Squamous Cell Carcinoma of the Oropharynx; Stage IV Verrucous Carcinoma of the Larynx; Stage IV Verrucous Carcinoma of the Oral Cavity

2014-05-19

337

Acetylcysteine Rinse in Reducing Saliva Thickness and Mucositis in Patients With Head and Neck Cancer Undergoing Radiation Therapy  

Science.gov (United States)

Mucositis; Oral Complications; Recurrent Adenoid Cystic Carcinoma of the Oral Cavity; Recurrent Basal Cell Carcinoma of the Lip; Recurrent Lymphoepithelioma of the Nasopharynx; Recurrent Lymphoepithelioma of the Oropharynx; Recurrent Mucoepidermoid Carcinoma of the Oral Cavity; Recurrent Salivary Gland Cancer; Recurrent Squamous Cell Carcinoma of the Larynx; Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity; Recurrent Squamous Cell Carcinoma of the Nasopharynx; Recurrent Squamous Cell Carcinoma of the Oropharynx; Recurrent Verrucous Carcinoma of the Larynx; Recurrent Verrucous Carcinoma of the Oral Cavity; Stage I Adenoid Cystic Carcinoma of the Oral Cavity; Stage I Basal Cell Carcinoma of the Lip; Stage I Lymphoepithelioma of the Nasopharynx; Stage I Lymphoepithelioma of the Oropharynx; Stage I Mucoepidermoid Carcinoma of the Oral Cavity; Stage I Salivary Gland Cancer; Stage I Squamous Cell Carcinoma of the Larynx; Stage I Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage I Squamous Cell Carcinoma of the Nasopharynx; Stage I Squamous Cell Carcinoma of the Oropharynx; Stage I Verrucous Carcinoma of the Larynx; Stage I Verrucous Carcinoma of the Oral Cavity; Stage II Adenoid Cystic Carcinoma of the Oral Cavity; Stage II Basal Cell Carcinoma of the Lip; Stage II Lymphoepithelioma of the Nasopharynx; Stage II Lymphoepithelioma of the Oropharynx; Stage II Mucoepidermoid Carcinoma of the Oral Cavity; Stage II Salivary Gland Cancer; Stage II Squamous Cell Carcinoma of the Larynx; Stage II Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage II Squamous Cell Carcinoma of the Nasopharynx; Stage II Squamous Cell Carcinoma of the Oropharynx; Stage II Verrucous Carcinoma of the Larynx; Stage II Verrucous Carcinoma of the Oral Cavity; Stage III Adenoid Cystic Carcinoma of the Oral Cavity; Stage III Basal Cell Carcinoma of the Lip; Stage III Lymphoepithelioma of the Nasopharynx; Stage III Lymphoepithelioma of the Oropharynx; Stage III Mucoepidermoid Carcinoma of the Oral Cavity; Stage III Salivary Gland Cancer; Stage III Squamous Cell Carcinoma of the Larynx; Stage III Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage III Squamous Cell Carcinoma of the Nasopharynx; Stage III Squamous Cell Carcinoma of the Oropharynx; Stage III Verrucous Carcinoma of the Larynx; Stage III Verrucous Carcinoma of the Oral Cavity; Stage IV Lymphoepithelioma of the Nasopharynx; Stage IV Squamous Cell Carcinoma of the Nasopharynx; Stage IVA Adenoid Cystic Carcinoma of the Oral Cavity; Stage IVA Basal Cell Carcinoma of the Lip; Stage IVA Lymphoepithelioma of the Oropharynx; Stage IVA Mucoepidermoid Carcinoma of the Oral Cavity; Stage IVA Salivary Gland Cancer; Stage IVA Squamous Cell Carcinoma of the Larynx; Stage IVA Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage IVA Squamous Cell Carcinoma of the Oropharynx; Stage IVA Verrucous Carcinoma of the Larynx; Stage IVA Verrucous Carcinoma of the Oral Cavity; Stage IVB Adenoid Cystic Carcinoma of the Oral Cavity; Stage IVB Basal Cell Carcinoma of the Lip; Stage IVB Lymphoepithelioma of the Oropharynx; Stage IVB Mucoepidermoid Carcinoma of the Oral Cavity; Stage IVB Salivary Gland Cancer; Stage IVB Squamous Cell Carcinoma of the Larynx; Stage IVB Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage IVB Squamous Cell Carcinoma of the Oropharynx; Stage IVB Verrucous Carcinoma of the Larynx; Stage IVB Verrucous Carcinoma of the Oral Cavity; Stage IVC Adenoid Cystic Carcinoma of the Oral Cavity; Stage IVC Basal Cell Carcinoma of the Lip; Stage IVC Lymphoepithelioma of the Oropharynx; Stage IVC Mucoepidermoid Carcinoma of the Oral Cavity; Stage IVC Salivary Gland Cancer; Stage IVC Squamous Cell Carcinoma of the Larynx; Stage IVC Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage IVC Squamous Cell Carcinoma of the Oropharynx; Stage IVC Verrucous Carcinoma of the Larynx; Stage IVC Verrucous Carcinoma of the Oral Cavity; Tongue Cancer

2014-05-01

338

Reproductibilit? des classifications OMS 1973 et OMS 2004 des tumeurs uroth?liales papillaires de la vessie  

Science.gov (United States)

Résumé Objectif : Déterminer les taux d’accord et la reproductibilité intra et inter-observateurs des classifications OMS 1973 et OMS 2004 des tumeurs urothéliales papillaires de la vessie. Matériel et méthodes : Cent deux cas de tumeurs urothéliales papillaires de stade pTa/pT1 ont été étudiés. Deux pathologistes ont revu les lames et ont établi le grade tumoral selon les deux classifications OMS 1973 et OMS 2004. En cas de désaccord, les deux évaluateurs ont procédé à une lecture commune au microscope en double tête afin d’aboutir à un grade consensuel selon les deux classifications. La variabilité intra-observateur a été étudiée chez l’un des deux évaluateurs qui a procédé à la relecture des lames un mois après sa première lecture. Les taux d’accord entre les deux pathologistes pour chaque catégorie de grade ont été déterminés et la reproductibilité des deux classifications a été évaluée à l’aide du coefficient kappa. Une valeur de 0 à 0,2 était interprétée comme un désaccord absolu, de 0,21 à 0,4, un accord faible, de 0,41 à 0,6, un accord modéré, de 0,61 à 0,8, un accord considérable, et de 0,8 à 1, un accord absolu. Résultats : Selon la classification OMS 1973, les proportions des grades G1, G2 et G3 étaient respectivement de 40,2 %, 50 % et 9,8 %. Selon la classification OMS 2004, les proportions respectives des tumeurs de faible potentiel de malignité, des carcinomes de bas grade et des carcinomes de haut grade de malignité étaient de 23,5 %, 60,8 % et 15,7 %. La reproductibilité intra-observateur était excellente pour les deux classifications (accord absolu). Les taux d’accord entre les deux pathologistes étaient meilleurs pour la classification OMS 2004 (kappa = 0,7) que pour la classification OMS 1973 (kappa = 0,51). Conclusions : La reproductibilité entre observateurs de la classification OMS 2004 est supérieure à celle de 1973. La reproductibilité intra-observateur est excellente pour les deux classifications.

Ben Abdelkrim, Soumaya; Rammeh, Soumaya; Trabelsi, Amel; Ben Yacoub-Abid, Lilia; Ben Sorba, Nabil; Jaidane, Lilia; Mokni, Moncef

2012-01-01

339

Is routine pathological examination required in South African children undergoing adenotonsillectomy?  

Scientific Electronic Library Online (English)

Full Text Available SciELO South Africa | Language: English Abstract in english OBJECTIVE: We aimed to determine the incidence of abnormal pathological findings in the tonsils and/or adenoids of children undergoing tonsillectomy and/or adenoidectomy, and the incidence of tuberculosis of the tonsils and adenoids; suggest criteria to identify children at risk for adenotonsillar t [...] uberculosis; and investigate the association between HIV and adenotonsillar abnormality, the cost-effectiveness of routine pathological examination of adenotonsillectomy specimens, and criteria to decide which specimens to send for histological examination. METHODS: We undertook an 8-month prospective study on all children (>12 years) undergoing consecutive tonsillectomy or adenotonsillectomy (T&A) at Red Cross War Memorial Children's Hospital. Patients were assessed pre-operatively and tonsil sizes graded pre- and intra-operatively. Blood was taken for HIV testing, and all tonsils and adenoids were examined histologically. A cost-benefit analysis was done to determine the cost-effectiveness of adenotonsillectomy routine pathology. RESULTS: A total of 344 tonsils were analysed from 172 children (102 boys, 70 girls); 1 patient had nasopharyngeal tuberculosis, and 1 lymphoma of the tonsils; 13 (7.6%) patients had clinically asymmetrically enlarged tonsils but no significant abnormal pathological finding. The average cost of detecting a clinically significant abnormality was R22 744 (R45 488 ÷ 2 abnormalities). CONCLUSIONS: The following criteria could improve cost-effectiveness of pathological examination of adenotonsillectomy specimens: positive tuberculosis contact at home, systemic symptoms of fever and weight loss, cervical lymphadenopathy >3 cm, suspicious nasopharyngeal appearance, HIV-positive patient, rapid tonsillar enlargement or significant tonsillar asymmetry. On our evidence, routine pathological investigation for South African children does not seem to be justified.

Anton C, van Lierop; C A J, Prescott.

340

CT and MRI diagnosis of tumor originating in the pterygopalatine fossa  

International Nuclear Information System (INIS)

Objective: To investigate the CT and MRI findings of tumors originating in the pterygopalatine fossa so as to promote the diagnostic accuracy. Methods: All 11 patients with tumors arising from the pterygopalatine fossa were confirmed by pathology and surgery. CT and MRI appearances were analyzed retrospectively. Results: The tumors included 3 neurilemmomas, 2 neurofibromas, 3 angiofibromas, 2 adenoid cystic carcinomas, and 1 melanoma, and they all extended through communicating pathways of the pterygopalatine fossa. On HRCT, neurogenic tumors caused enlargement of the pterygopalatine fossa with thinning of their bony walls, while MRI demonstrated isointense signal to brain on T1WI and hyperintense signal on T2WI. Two neurofibromas showed homogeneous enhancement after administration of contrast medium while 3 neurilemmomas showed heterogeneous enhancement. On HRCT scans, angiofibroma caused enlargement of the pterygopalatine fossa, eroding their bony walls. On MR imaging, the lesions were isointense compared to muscle on T1WI, hyperintense on T2WI with marked postcontrast enhancement. One case of angiofibroma showed scattered stippling or stria-shaped signal voids and inhomogeneous postcontrast enhancement. On CT scans, adenoid cystic carcinoma revealed moth-eaten bony wall of the pterygopalatine fossa with poorly defined margins and irregular shapes. Adenoid cystic carcinoma showed hypointense signal compared to muscle on T1WI, inhomogeneous hyperintense signal on T2WI and heterogeneous postcontrast enhancement. One case of melanoma showed enlargement of pterygopalatine fossa and destruction of the bony walls except for the anterior wall by invading adjacent structures with well-defined border and irregular shape. On MR imaging, the lesion showed isointense signal compared to muscle on T1WI and hyperintense signal on T2WI with discrete mottled or linear signal voids and inhomogeneous postcontrast enhancement. Conclusion: HRCT can depict bony changes clearly and MRI can demonstrate optimally the extent of the lesion in pterygopalatine fossa. Both imaging modalities can contribute to the diagnosis of neurogenic tumor and angiofibroma and can provide information for therapeutic procedure and surgical planning

2003-10-01

 
 
 
 
341

Bronchial adenoma: review of 18-year experience at the Brompton Hospital.  

Science.gov (United States)

Continued uncertainty about the prognosis for patients with bronchial adenomata led to a review of the experience of this condition in the Brompton Hospital. Of 72 patients seen between January 1955 and December 1972, 39 were women and 33 men, mean age 45 years, range 9-73 years. The commonest presenting symptoms were haemoptysis, cough, sputum, and repeated chest infections. Positive bronchoscopic biopsy occurred in 35 of 43 cases; five of these were originally reported as carcinomata, of oat-cell type in four. Plain chest film abnormality occurred in 69 patients. Seventy-three operative procedures comprised two endoscopic removals, two wedge resections, six bronchotomies, five pneumonectomies, and 58 lobectomies (seven with sleeve resection). Recurrence in three of six bronchotomies--two with adenoid cystic carcinomata (cylindromata)--necessitated further surgery. Lobectomy and lymph node dissection is usually the operation of choice. Histology confirmed 67 carcinoids (eight with atypical histology or lymph node metastases), two adenoid cystic carcinomata, one muco-epidermoid, and two mucous gland adenomata. Prolonged follow-up is especially indicated in patients with adenoid cyst carcinoma and in those with atypical or metastatic carcinoid histology. Although such pathology is not incompatible with long survival, of 10 patients in these categories, all five late deaths were probably related to the tumour. However, of 57 patients considered to have had typical carcinoid histology and adequate removal of the tumour, there has to date been no tumour-related death, but one patient developed radiosensitive atypical carcinoid tracheal tumours nine years later. The actuarially assessed survival of 71 patients undergoing surgery for bronchial adenomata was 75% at 15 years. Specific tumour types should replace the term bronchial adenoma. PMID:181862

Lawson, R M; Ramanathan, L; Hurley, G; Hinson, K W; Lennox, S C

1976-06-01

342

Evaluación del adenoidismo en los niños: imagen endoscópica  

Directory of Open Access Journals (Sweden)

Full Text Available El adenoidismo es un síndrome complejo cuya causa principal se identifica generalmente con la hiperplasia de las amígdalas y la nasofaringe, pero abarca también diversos aparatos y estructuras que aún cuando se encuentran lejos de la nasofaringe, se relacionan funcionalmente con ella. Las afecciones locales caracterizadas por obstrucción nasal y rinorrea a menudo purulentas, se asocian con enfermedades de los senos (sinusitis, con afecciones del oído (otalgia, otorrea serosa o serosa-purulenta o ambas cosas, así como hipoacusia, con enfermedades de la laringe (disfonía y afonía, con afecciones de las vías respiratorias inferiores (tos, bronquitis recurrente, con enfermedades de los huesos de la cara (paladar ojival, deficiencia de la oclusión dental, así como con afecciones sistémicas (apnea del sueño, OSAS. La endoscopia de fibra óptica es la prueba de selección para valorar la calidad y la extensión de la hipertrofia de las adenoidesAdenoidism is a complex syndrome whose main cause is generally identified with hyperplasia of the tonsils and nasopharynx, but it also involves diverse systems and structures that even when they are not close to the nasopharynx are functionally related to it. The local affections characterized by usually purulent nasal obstruction and rhinorrea are associated with diseases of the sinuses (sinusitis, with affections of the ear (otalgia, serous or serouspurulent otorrhoea or both, as well as hypoacusia, with larynx diseases (dysphonia and aphonia, with affections of the lower airways (cough, recurrent bronchitis, with face bone diseases (ogival palate, deficiency of dental oclussion, as well as systemic affections (sleep apnea, OSAS. The optic fibre endoscopy is the selection test to asses the quality and extension of adenoids hypertrophy

Calogero Grillo

2000-12-01

343

Radiation doses and neutron irridation effects on human cells based on calculations  

Science.gov (United States)

In general, main aim of our paper is to follow influence of neutron's radiation on materials, but one of possible applications of fast neutrons in therapeutical reasons i.e. their influence on carcinom cells of difficuilt geometries in human bodies too. Interactions between neutrons and human cells of tissue are analysed here. We know that the light nuclei of hydrogen, nitrogen, carbon, and oxygen are main constituents of human cells, and that different nuclear models are usually used to present interactions of nuclear particles with mentioned elements. Some of most widely used pre-equilibrium nuclear models are: intranuclear cascade model (ICN), Harp-Miller-Berne (HMB), geometry-dependent hybrid (GDH) and exciton models (EM). In this paper is studied and calculated the primary energetic spectra of the secundary particles (neutrons, protons, and gamas) emitted from this interactions, and followed by corresponding integral cross sections, based on exciton model (EM). The total emission cross-section is the sum of emissions in all stages of energies. Obtained spectra for interactions type of (n, n'), (n, p), and (n, ?), for various incident neutron energies in the interval from 3 MeV up to 30 MeV are analysed too. Some results of calculations are presented here.

Radojevic, B. B.; Cukavac, M.; Jovanovic, D.

344

Breast cancer: Early detection - increasing mortality rates; Mammacarcinom: Erfolgreiche Fruehdiagnose, steigende Mortalitaet  

Energy Technology Data Exchange (ETDEWEB)

Mammography, sonography and nmr imaging are the tools that will in all probability detect breast cancer at an early stage. NMR imaging is the most recently developed and most sophisticated high-tech method for the diagnosis of disorders of the mammary parenchyma. To ensure a better differentiation between benign and malignant changes, nmr imaging of the breast is carried out following paramagnetic opacification using intravenous gadolinium DTPA. Owing to their angiogenic potential and increased vascular permeability carcinomas are characterized by a significant contrast medium accumulation. The signal intensities of malignant tumours are therefore higher than those of the adjacent supporting and fatty tissues or the intact mammary parenchyma. (orig./VHE) [Deutsch] Die Diagnostik des fruehen Mammacarcinoms gelingt mit Hilfe der Mammographie, Sonographie und Kernspintomographie. Die Kernspintomographie stellt gegenwaertig das neueste und apparatetechnisch aufwendigste Verfahren zur Diagnostik der Mammaparenchymerkrankungen dar. Zur besseren Differenzierung von malignen und benignen Veraenderungen wird die Kernspintomographie der Brust nach intravenoeser Applikation des paramagnetischen Kontrastmittels Gadolinium-DTPA durchgefuehrt. Carcinome zeigen aufgrund ihrer angiogenetischen Potenz und ihrer erhoehten Gefaesswandpermeabilitaet eine signifikante Kontrastmittelanreicherung. Maligne Tumoren stellen sich deshalb signalreicher dar als das umliegende Stuetz-, Fettgewebe und gesundes Mammaparenchym. (orig./VHE)

Paterok, E.M. [Universitaets-Frauenklinik, Erlangen (Germany); Siebzehnruebl, E. [Universitaets-Frauenklinik, Erlangen (Germany); Schulz-Wendtland, R. [Universitaets-Frauenklinik, Erlangen (Germany); Koch, T. [Universitaets-Frauenklinik, Erlangen (Germany)

1995-05-01

345

M?tastase spl?nique d'un ad?nocarcinome colique - ? propos d'un cas et revue de la litt?rature  

Science.gov (United States)

L'atteinte métastatique de la rate est rare et exceptionnellement isolée. En effet, elle survient généralement dans le cadre d'une atteinte multi viscérale. Les cancers les plus pourvoyeurs de métastase splénique sont les mélanomes, les carcinomes de l'ovaire, du sein et du poumon. Dans le cancer colique, l'atteinte métastatique isolée de la rate est rare, dix cas seulement ont été décrits dans la littérature jusque-là. À travers cette revue, nous décrivons un nouveau cas présentant un adénocarcinome colique avec métastase splénique métachrone, tout en discutant les aspects cliniques et les différentes approches thérapeutiques décrites dans la littérature. Nous rapportons un nouveau cas d'un patient âgé de 46ans ayant un adénocarcinome colique traité, et qui a présenté 5 ans plus tard une métastase splénique de découverte fortuite lors d'un bilan radiologique de surveillance, pour laquelle le patient a bénéficié d'une splénectomie suivie d'une chimiothérapie systémique avec une bonne évolution. Les métastases spléniques isolées des tumeurs solides sont rares, et leur diagnostic est souvent de découverte fortuite. La splénectomie totale est un moyen efficace de faire le diagnostic définitif de ces métastases et de les traiter afin de prévenir les complications et d'améliorer la survie.

El M'rabet, Fatima Zahra; Brahmi, Sami Aziz; Rachidi, Siham; Tizniti, Siham; Amaarti, Afaf; Ait Taleb, Khalid; El Mesbahi, Omar

2011-01-01

346

La forme pseudo tumorale de la tuberculose primitive du nasopharynx: ? propos de deux nouvelles observations et revue de la litt?rature  

Science.gov (United States)

La tuberculose primitive du nasopharynx est rare, nous présentons deux observations révélées par un aspect pseudo tumoral et à travers lesquelles nous soulevons le problème de diagnostic différentiel avec les lésions malignes du nasopharynx. La première observation concerne un jeune patient de 22 ans hospitalisé pour obstruction nasale bilatérale évoluant dans un contexte d'apyrexie et de conservation de l’état général. La nasofibrosopie et le scanner ont monté un processus tumoral évoquant une hypertrophie des végétations adénoïdes. Le deuxième cas est celui d'un homme de 45 ans tabagique chronique qui a présenté une adénopathie latérocervicale droite, une obstruction nasale et une otite séromuqueuse homolatérale. La nasophibroscopie et le scanner on montré un bourgeon tumoral postéro latéral droit du nasopharynx évoquant un carcinome nasopharyngé. Les biopsies du nasopharynx et les études histologiques, chez les deux patients, ont confirmé le diagnostic de tuberculose. La recherche d'autres localisations était négative. Le pronostic était favorable après 6 mois de traitement antibacillaire. La tuberculose primitive du cavum est rare, elle revêt le plus souvent des formes pseudotumorales et pose des problèmes de diagnostic différentiel avec les tumeurs nasopharyngées, son pronostic sous traitement antibacillaire est.

Touati, Mohammed; Aljalil, Abdelfettah; Chihani, Mehdi; Bouchentouf, Rachid; Bouaity, Brahim; Ammar, Haddou

2013-01-01

347

Charges in haemostasis during radiotherapy of uterine carcinoma  

International Nuclear Information System (INIS)

Clinical chemical parameters for coagulation and fibrinolysis were determined in 20 patients suffering from uterine cancer both during radium implantation with low dose anticoagulation and during the time period of percutaneous post-irradiation. In spite of strong immobilization the partial anticoagulation stabilised haemostasis. A large increase in fibrinogen concentration within the normal range of values, caused by increased production and release from the outer areas of the tumour, cannot be prevented. In addition, in the majority of cases there is a drop in AT III concentration in the pathological range. Percutaneous post-irradiation treatment for further tumour regression leads to a stabilization of the overall tests for clotting. The activated fibrinolysis and elevated levels of fibrin clearage products noted at commencement of the tests showed a normalizing tendency with progressing tumour regression and this was accompanied by a decrease in fibrinogen concentration. A low-dose anticoagulation with 3 x 5000 USP E. Heparin subcutaneous can be recommended as clinical consequences for treating frequently adipose carcinomal patients. Optimal commencement of anticoagulation is 3 hr. pre-operative. (orig./MG)

1981-01-01

348

Suppression of pulmonary tumor promotion and induction of apoptosis by Crocus sativus L. extraction.  

Science.gov (United States)

Crocus sativus L., commonly known as saffron, is the raw material for one of the most expensive spice in the world, and it has been used in folk medicine for centuries. We investigated the potential of the ethanolic extract of saffron to induce cytotoxic and apoptosis effects in carcinomic human alveolar basal epithelial cells (A549), a commonly used cell culture system for in vitro studies on lung cancer. The cells were cultured in Dulbecco's modified Eagle's medium with 10% fetal bovine serum treated with different concentrations of the ethanolic extract of saffron for two consecutive days. Cell viability was quantitated by the 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide assay. Apoptotic cells were determined using annexin V-fluorescein isothiocyanate by flow cytometry. Saffron could decrease the cell viability in the malignant cells as a concentration- and time-dependent manner. The IC?? values against the A549 cell lines were determined as 1,200 and 650 ?g/ml after 24 and 48 h, respectively. Saffron-induced apoptosis of the A549 cells in a concentration-dependent manner, as determined by flow cytometry histogram of treated cells that induced apoptotic cell death, is involved in the toxicity of saffron. It might be concluded that saffron could cause cell death in the A549 cells, in which apoptosis plays an important role. Saffron could also be considered as a promising chemotherapeutic agent in lung cancer treatment in future. PMID:21153568

Samarghandian, Saeed; Tavakkol Afshari, Jalil; Davoodi, Saeideh

2011-05-01

349

Use of in vitro assays to assess the potential antiproliferative and cytotoxic effects of saffron (Crocus sativus L.) in human lung cancer cell line  

Science.gov (United States)

Background: Saffron is harvested from the dried, dark red stigmas of Crocus sativus flowers. It is used as a spice for flavoring and coloring food as a perfume. It is often used for treating several diseases. We investigated the potential of the ethanolic extract of saffron to induce antiproliferative and cytotoxic effects in cultured carcinomic human alveolar basal epithelial cells in comparison with non-malignant (L929) cells. Materials and Methods: Both cells were cultured in Dulbecco’s modified Eagle’s medium and treated with the ethanolic extract of saffron at various concentrations for two consecutive days. Our study resulted in sequences of events marked by apoptosis, such as loss of cell viability, morphology changes that were evaluated by MTT assay and invert-microscope, respectively. Results: The results showed that the ethanolic extract of saffron decreased cell viability in malignant cells as a concentration and time-dependent manner. The IC 50 values against the lung cancer cell line were determined as 1500 and 565 ?g/ml after 24 and 48 h, respectively. However, the extract at different concentrations could not significantly decrease the cell viability in L929 cells. Morphology of MCF7 cells treated with the ethanolic extract confirmed the MTT results. Conclusion: We also showed that even higher concentrations of saffron is safe for L929, but the extract exerts pro-apoptotic effects in a lung cancer-derived cell line and could be considered as a potential chemotherapeutic agent in lung cancer.

Samarghandian, Saeed; Boskabady, Mohammad Hossein; Davoodi, Saideh

2010-01-01

350

Cell uptake and oral absorption of titanium dioxide nanoparticles.  

Science.gov (United States)

Large efforts are invested on the development of in vitro tests to evaluate nanomaterial (NM) toxicity. In order to assess the relevance of the adverse effects identified in in vitro toxicity tests a thorough understanding of the biokinetics of NMs is critical. We used different in vitro and in vivo test methods to evaluate cell uptake and oral absorption of titanium dioxide nanoparticles (TiO2 NPs). These NPs were readily uptaken by A549 cells (carcinomic human alveolar basal epithelial cells) in vitro. Such rapid uptake contrasted with a very low oral absorption in a differentiated Caco-2 monolayer system (human epithelial colorectal adenocarcinoma cells) and after oral gavage administration to rats. In this oral study, no significant increase in the levels of titanium was recorded by ICP-MS in any of the tissues evaluated (including among other: small intestine, Peyer's patches, mesenteric lymph nodes, liver, and spleen). No NPs were observed by TEM in sections of the small intestine, except for several particles in the cytoplasm of a cell from a Peyer's Patch area. The observation of NPs in Peyer's Patch suggests that the Caco-2 monolayer system is likely to underestimate the potential for oral absorption of NPs and that the model could be improved by including M-cells in co-culture. PMID:24793716

Janer, G; Mas Del Molino, E; Fernández-Rosas, E; Fernández, A; Vázquez-Campos, S

2014-07-15

351

Cancer du sein de l'homme: ? propos de 6 cas  

Science.gov (United States)

Le but de ce travail était d'analyser les caractéristiques cliniques, histologiques, thérapeutiques et pronostiques du cancer du sein chez l'homme. Il s'agissait d'une étude rétrospective portant sur six patients colligés au service de gynécologie obstétrique II, CHU Hassan II durant la période 2009-2012. L’âge moyen de nos patients est de 65.3 ans. Il s'agit dans 83.3% des cas, d'une tumeur rétroaréolaire dont la taille moyenne est de 44.16 mm. Nous avons retrouvé 4 (66.7%) T4, 1 (16.7%) T3 et dans un cas, une tumeur inclassable. Le type histologique le plus représenté est le carcinome canalaire infiltrant (66.7%). Le taux d'envahissement ganglionnaire axillaire est de 66.7%. L'hormonodépendance de ces tumeurs est prouvée dans 100% des cas. La survie à cinq ans est en cours d’évaluation. L'envahissement ganglionnaire, l'invasion du derme, le stade clinique TNM sont des facteurs qui influencent significativement la survenue de métastases. Aucun de ces facteurs de risque n'est apparu significatif en termes de survie globale. Le cancer du sein chez l'homme est une maladie rare (environ 1% des cancers du sein) au pronostic sombre. Le diagnostic est le plus souvent tardif et les lésions sont traitées à des stades avancés.

Laabadi, Kamilia; Jayi, Sofia; Alaoui, Fatimazohra Fdili; Bouguern, Hakima; Chaara, Hikmat; Melhouf, My Abdelilah; Hassani, Karim Ibn Majdoub; Laalim, Said Ait; Anoun, Hicham; Toughrai, Imane; Mazaz, Khalid

2013-01-01

352

Clinical application of a new 0.63- to 0.65-um pulse diode laser in treating ear, throat, and nose diseases in adults and children  

Science.gov (United States)

An investigation was made of applying a pulsed diode laser emitting at the wavelengths of 0.63 to 0.65 micrometers to treat various otolaryngological diseases, such as rhinosinusitis, acute rhinitis, vasomotor rhinitis, allergic rhinitis, the illness of the lymphoid ring, adenoiditis, chronic tonsillitis, pharyngitis, and catarrhal and suppurative otitis. The therapeutic effect produced by the pulsed diode laser was compared with that of conventional therapeutic lasers. It was found that the pulsed low-intensity laser radiation in the red spectrum region offered a number of advantages over conventional laser therapeutic techniques.

Nasedkin, Alexy N.; Pletnev, A. S.

2001-04-01

353

DF3 (CA15-3) antibody as a marker of cutaneous adnexal tumors.  

Science.gov (United States)

DF3(CA15-3) monoclonal antibody detects the 20 amino acid sequence of epithelial mucin. In normal cutaneous tissue DF3 antibody exhibits strong and constant positive reactivity with sebaceous and secretory segments of eccrine and apocrine sweat glands. All epidermal tumors are DF3 negative but poorly differentiated squamous cell carcinoma. Various adnexal tumors such as eccrine hidrocystoma, tubular apocrine adenoma, syringocystadenoma papilliferum, eccrine poroma, eccrine spiradenoma, clear cell hidradenoma, mixed cell tumor, eccrine porocarcinoma, extramammary Paget's disease and adenoid cystic carcinoma are DF3 positive, which indicates epithelial mucin production by these tumors. PMID:7911637

Yasui, S; Ando, I; Kukita, A; Hino, H; Ohara, K

1994-03-01

354

The double contrast examination of the colon  

International Nuclear Information System (INIS)

The double contrast method has been modified in order to get a more detailed picture of the mucous membrane of the colon. The method has been employed at Malmoe hospital since 1953. The method and its diagnostic application in cases of adenoids, villiferous tumours, diverticula, Crohn's disease, ulcerating colitis, and deformation of the rectum/sigma junction due to external endometriosis and peritoneal carcinosis are described. The diagnostic values of the double contrast method and colposcopy/biopsy of the colon are compared. The two methods are found to be complementary. (MG)

355

Submaxilectomía: causas y complicaciones. Revisión de 160 casos / Submandibular gland excisions: causes and complications. A review of 160 cases  

Scientific Electronic Library Online (English)

Full Text Available SciELO Spain | Language: Spanish Abstract in spanish Objetivo: Presentamos una revisión de 160 submaxilectomías realizadas en el Hospital La Paz de Madrid durante 10 años. Material y métodos: Se revisan retrospectivamente todas las historias clínicas de los pacientes intervenidos de submaxilectomía desde enero de 2001 hasta julio de 2011. En los datos [...] se incluyen sexo, edad, anatomía patológica, pruebas diagnósticas, procedimientos quirúrgicos y seguimiento. Comparamos nuestro estudio con otros similares publicados en otros países. Resultados: En nuestra serie la sialoadenitis crónica y la sialolitiasis de la glándula submaxilar representan 114 casos (71,25%). Hay 36 casos de neoplasias (78,88% benignas y 22,22% malignas). El tumor benigno más frecuente es el adenoma pleomorfo (26 casos) y el tumor maligno más frecuente es el carcinoma adenoide quístico (7 casos). Conclusiones: En nuestro centro la causa más frecuente de submaxilectomía la constituyen la sialoadenitis crónica y la sialolitiasis. Las neoplasias más frecuentes son el adenoma pleomorfo y el carcinoma adenoide quístico, en consonancia con diferentes estudios de otros países. Los tumores benignos son más frecuentes, en contraste con otros estudios previos. Abstract in english Objective: A review is presented of 160 sub-mandibular gland excisions performed at third level hospital over a ten year period. Patients and methods: The medical records and case notes of all patients with submandibular gland excision were reviewed retrospectively from January 2001 to July 2011. Th [...] is data included gender, age, histopathology of the submandibular gland, diagnostic procedures, surgical reports, and follow-up. This study was also compared with similar studies published in other countries. Results: Chronic sialadenitis and sialolithiasis of the submandibular gland was found in 114 cases (71.25%) of the series. Thirty-six neoplasms (78.88% benign and 22.22% malignant) were found. The most frequent benign and malignant neoplasms found were pleomorphic adenoma (26 cases) and adenoid cystic carcinoma (7 cases), respectively. Conclusions: The present study showed that the main cause of sub-mandibular gland excision in our reference population was sialadenitis and sialolithiasis. The most frequent neoplasms were pleomorphic adenoma and adenoid cystic carcinoma, similar to other published reports. In this study, there was a higher incidence of benign neoplasms than in previous reports. The most common complication was facial nerve neuropraxia.

Daniel, García Molina; Rocío, Sánchez Burgos; José Luis del, Castillo Pardo de Vera; María José, Morán Soto; Natàlia, Gisbert Alemany; Miguel, Burgueño García.

356

Computer tomographic volume measurements of pneumatisation of the ear  

International Nuclear Information System (INIS)

The volume of the pneumatised portion of the ear was determined by computed tomography in 235 patients. Amongst the 470 ears examined, 320 had no disease in the ear, nose or throat. Normal pneumatisation of the ear can be quantified by CT and strict correlation has been demonstrated between the air content and age from ten to 17 years. Chronic inflammatory processes of the middle ear occurring during childhood interfere with pneumatisation on one or both sides. The most severe failure of pneumatisation occurs with congenital abnormalities of the ear, most cases never showing significant pneumatisation. Chronic infection of the tonsils or adenoids causes much less interference with pneumatisation. (orig.)

1984-02-01

357

Basal cell carcinoma arising on the skin with chronic radiation dermatitis  

International Nuclear Information System (INIS)

In a 86-year-old woman, basal cell carcinoma (BCC) arose on the skin with chronic radiation dermatitis. She, at the age of 46, received irradiation to the abdomen for cancer of the uterine cervix. Radiation source and dose were unknown. A verrucous eruption appeared on the irradiated field of the right abdomen, and gradually expanded. Histological examination showed that proliferation of tumor cells with adenoid and cystose structure extended to the epidermis. Electron microscopic study showed both clear and dark tumor cells, although dark cells were few in number. A review of the literature showed that BCC arising on the skin with chronic radiation dermatitis is uncommon in Japan. (Namekawa, K.)

1986-01-01

358

Facial and trigeminal neural dysfunction by a primary cutaneous squamous cell carcinoma: MRI and clinicopathologic correlates.  

Science.gov (United States)

Carcinomatous neural infiltration and subsequent neural dysfunction are phenomena associated with the facial nerve and parotid gland tumors, particularly adenoid cystic carcinoma. The association of primary cutaneous squamous cell carcinoma (PCSCC) with these phenomena is not as well recognized, especially with respect to the involvement of the trigeminal nerve. By presenting the case history of a man who successively developed facial and trigeminal neural dysfunction after Mohs chemosurgery of a PCSCC, this paper documents histologically the occurrence of such neural invasion, and illustrates the utility of gadolinium-enhanced magnetic resonance scanning in patient management. PMID:1449189

Gulya, A J; Scher, R; Schwartz, A; Wilson, W R

1992-11-01

359

Incidence of Helicobacter pylori infection and their clarithromycin-resistant strains in otitis media with effusion regarding phenotypic and genotypic studies.  

Science.gov (United States)

Helicobacter pylori (H. pylori) are pathogenic bacteria that infect a half of the human population, colonize gastric mucosa and can be found in gastric juice. Reflux of gastric juice has been suggested to be associated with glue ear in children. It has been suggested that tonsil and adenoid tissues are potential reservoirs of H. pylori infection. These observations raise the question as to whether H. pylori infection might have a role in otitis media with effusion (OME) in children. The objectives of this research were to evaluate the incidence and possible role of H. pylori in the pathogenesis of OME in children and to evaluate the clarithromycin-resistant strains. Molecular assessment was done to evaluate the culture results vs. molecular study. A total of 60 children, who were prone to ventilation tube insertion, adenoidectomy and/or tonsillectomy were included in the study. The control group consisted of 40 children who underwent adenoidectomy and/or tonsillectomy without the history of OME. Samples of the middle ear fluid and mucosa, adenoid tissue, tonsillar tissue and gastric lavage were cultured and underwent polymerase chain reaction (PCR) analysis then were assembled by using QIAxcel System as capillary electrophoresis for H. pylori detection. There was significant difference between the results of cultures and PCR (P < 0.05). Middle ear fluid culture was positive for H. pylori in 40% of the patients vs. 56.7% PCR results while middle ear mucosa culture was positive in 20% vs. 26.7% PCR results. Gastric lavage culture was positive in 46.6% of the patients and PCR was positive in 63.3% of the patients. Adenoid culture and PCR were positive in 56.3% for each, while tonsil culture was positive in 70% and PCR was positive in 90%. H. pylori presence in the gastric lavage, the tonsillar and adenoid tissues by culture and PCR was significantly more frequent in the study group compared to the control group. The minimum inhibitory concentration (MIC) values of clarithromycin-resistant isolates ranged from 1.5 to 8 ?g/ml. This study showed the presence of H. pylori in around 50% of the patients with OME. PCR revealed its sensitivity than culture techniques. The incidence of clarithromycin resistance was found to be high among the isolates (39.6%). PMID:23960809

Melake, Nahla A; Shaker, Ghada H; Salama, Magdy A

2012-10-01

360

Treatment results of combined hyperthermia/radiotherapy  

International Nuclear Information System (INIS)

The authors present their own treatment results and those published in literature and give a critical overview over the present treatment modalities in combined hyperthermia/radiotherapy. Advanced superficially and half deep seated tumors are best suited. The authors treated 124 squamous-cell and 16 adenoid-cystic carcinomas of the head and neck area. Remission rates after combined treatment were superior to those obtained by radiotherapy alone. Apart from this superior palliative effect an improvement of survival rates could not be observed until now. (orig.)

1989-01-01

 
 
 
 
361

Status report of fast neutron therapy in the Department of Radiotherapy at the University Hospital Hamburg-Eppendorf  

International Nuclear Information System (INIS)

Since 1976 710 patients were treated with fast neutrons at the University Hospital Hamburg-Eppendorf. Since January 1984 154 patients with soft tissue sarcomas (250 patients with soft tissue sarcomas since 1976), 20 patients with advanced and low grade tumors of the paranasal sinuses and 43 patients with adenoid cystic carcinomas were treated with fast neutrons. Our results and reports from several centers indicate a gain from fast neutron therapy for low grade soft tissue sarcomas, osteosarcomas (G1 and G2), for highly differentiated salivary gland tumors and some other rare low grade tumors as malignant chordomas, chrondrosarcomas, pencil gliomas or desmoid tumors. (orig.)

1990-01-01

362

Uncommon breast lesions. Radiologic and pathologic findings  

International Nuclear Information System (INIS)

To illustrate the radiologic findings in several uncommon breast and infrequent diseases that present with unusual mammographic images. We reviewed the mammograms performed in our department between 1998 and 1995, selecting 16 patients (12 women and 4 men). Nine patients had benign breast lesions (adenomyoepithelioma, epidermal cyst, adenoid cystic carcinoma, myofibroblastoma, multiple hamartomas, intra cystic papillomas, lipoma, idiopathic granulomatous mastitis and fat necrosis) and 7 patients presented malignant breast diseases (malignant fibrous histiocytoma, intra cystic carcinoma, primary lymphoma of the breast, liposarcoma and metastasis). We present a review of the radiologic and pathologic findings in several uncommon breast diseases. (Author) 14 refs

1998-01-01

363

Identificación de Colágeno I y III con Picrosirius Red/ Polarización en el Estroma de Tumores Salivales / Identification of Type I and III Collagen by Picrosirius Red/Polarization of Tumoral Salivary Stroma  

Scientific Electronic Library Online (English)

Full Text Available SciELO Chile | Language: Spanish Abstract in spanish El estroma juega un rol importante en los procesos tumorales de invasión y metástasis. Las fibras de colágeno tipo I son el principal componente estructural del estroma en distintos tumores. Sin embargo, hay muy pocos estudios en los tumores de glándulas salivales. Basándonos en estos antecedentes e [...] l objetivo de la presente comunicación fue estudiar las características del colágeno con Picrosirius red/polarización en tumores benignos y malignos de glándulas salivales para evaluar su posible rol en los mecanismos de progresión tumoral. Cortes histológicos de adenoma pleomórfico, carcinoma adenoide quístico y carcinoma epitelial mioepitelial se colorearon con H/E y Picrosirius red y se examinaron con microscopio de polarización. La birrefringencia del colágeno con Picrosirius/polarización resultó diferente en el estroma de los tumores malignos (carcinoma adenoide quístico y carcinoma epitelial mioepitelial), con predominio de colágeno I, en comparación con el tumor benigno (adenoma pleomórfico), con predominio de colágeno III. El diferente perfil de coloración en las fibras colágenas producidas en el estroma de los tumores analizados podría relacionarse con diferentes mecanismos de expansión tumoral, los que fueron poco estudiados en los tumores de glándulas salivales. Más estudios son necesarios para obtener resultados más concluyentes que contribuyan al diagnóstico, pronóstico y tratamiento. Abstract in english The stroma plays an important rol in tumoral invasion and metastasis. Type I collagen is the main structural component of the stroma in several tumors. However, there are few studies on salivary gland tumors. Based on this background the objective of the present communication was to study collagen c [...] haracteristics with picrosirius red/polarization on malignant and benign tumors of salivary glands to evaluate its posible rol in the tumoral progression mechanism. Histological sections of pleomorphic adenoma, adenoid cystic carcinoma and epithelial/myoepithelial carcinoma were stained with H/E and picrosirius red and were studied with polarization microscope. Collagen birefringence with Picrosirius/polarization was different in the malignant tumor stroma (adenoid cystic carcinoma and epithelialmyoepithelial carcinoma), with predominance of type I collagen, compared with a benign tumor (pleomorphic adenoma), with predominance of type III collagen. The different staining profile in collagen fibers produced in the benign and malignant stroma tumors analized could be related with different tumoral expansion mechanism, which were scarce studied on the salivary glands tumors. More studies are needed to obtain more conclusive results to contribute to diagnosis, prognosis and treatment.

Samar, Maria Elena; Ávila, Rodolfo Esteban; Asis, Onell Gabriela; Fonseca, Ismael; Corball, Alberto.

364

Incidence of Helicobacter pylori infection and their clarithromycin-resistant strains in otitis media with effusion regarding phenotypic and genotypic studies  

Science.gov (United States)

Helicobacter pylori (H. pylori) are pathogenic bacteria that infect a half of the human population, colonize gastric mucosa and can be found in gastric juice. Reflux of gastric juice has been suggested to be associated with glue ear in children. It has been suggested that tonsil and adenoid tissues are potential reservoirs of H. pylori infection. These observations raise the question as to whether H. pylori infection might have a role in otitis media with effusion (OME) in children. The objectives of this research were to evaluate the incidence and possible role of H. pylori in the pathogenesis of OME in children and to evaluate the clarithromycin-resistant strains. Molecular assessment was done to evaluate the culture results vs. molecular study. A total of 60 children, who were prone to ventilation tube insertion, adenoidectomy and/or tonsillectomy were included in the study. The control group consisted of 40 children who underwent adenoidectomy and/or tonsillectomy without the history of OME. Samples of the middle ear fluid and mucosa, adenoid tissue, tonsillar tissue and gastric lavage were cultured and underwent polymerase chain reaction (PCR) analysis then were assembled by using QIAxcel System as capillary electrophoresis for H. pylori detection. There was significant difference between the results of cultures and PCR (P < 0.05). Middle ear fluid culture was positive for H. pylori in 40% of the patients vs. 56.7% PCR results while middle ear mucosa culture was positive in 20% vs. 26.7% PCR results. Gastric lavage culture was positive in 46.6% of the patients and PCR was positive in 63.3% of the patients. Adenoid culture and PCR were positive in 56.3% for each, while tonsil culture was positive in 70% and PCR was positive in 90%. H. pylori presence in the gastric lavage, the tonsillar and adenoid tissues by culture and PCR was significantly more frequent in the study group compared to the control group. The minimum inhibitory concentration (MIC) values of clarithromycin-resistant isolates ranged from 1.5 to 8 ?g/ml. This study showed the presence of H. pylori in around 50% of the patients with OME. PCR revealed its sensitivity than culture techniques. The incidence of clarithromycin resistance was found to be high among the isolates (39.6%).

Melake, Nahla A.; Shaker, Ghada H.; Salama, Magdy A.

2012-01-01

365

Primary tumors of the trachea. Results of radiation therapy  

Energy Technology Data Exchange (ETDEWEB)

From 1959 to 1986, 24 patients with primary malignant tumors of the trachea received radiotherapy as all or part of treatment. Common presentations included respiratory symptoms in 20 patients and hemoptysis in 15. Thirteen patients had squamous carcinomas with undifferentiated and adenoid cystic cancers in five and four patients, respectively. Overall actuarial survival was 45% at 1 year, 25% at 5 years, and 13% at 10 years. Survival was significantly correlated to histologic type (adenoid cystic versus squamous, P less than 0.03), but not to tumor extent or to patient age or sex. Local control was attained in 10 of 24 patients overall and was more frequent for patients with tumors localized to the trachea and for patients who were treated with combined surgery and radiotherapy. For the 18 patients treated with radiotherapy alone, complete response (CR) was seen to be significantly (P less than 0.001) related to dose: six of seven (86%) patients receiving greater than or equal to 6000 cGy attained CR versus one of 11 (9%) receiving less than 6000 cGy. Three patients developed complications related to radiotherapy. Radiotherapy can provide durable local control of localized tracheal tumors and should be considered for medically inoperable patients with localized tumors and for patients with high risk of recurrence after resection.

Fields, J.N.; Rigaud, G.; Emami, B.N.

1989-06-15

366

CT findings of malignant nasal cavity tumors  

International Nuclear Information System (INIS)

To evaluate the CT findings of malignant nasal cavity tumors. Retrospective analysis was performed on 20 patients with pathologically-proven malignant nasal cavity tumors. Using CT, we analysed their location, extent of bone destruction and of involvement of adjacent structures, and enhancing pattern. A total of 20 cases included nine squamous cell carcinomas, three olfactory neuroblastomas, three lymphomas, two polymorphic reticulosis, one adenoid cystic carcinoma, one undifferentiated carcinoma and one metastasis from renal cell carcinoma. All cases except one adenoid cystic carcinoma and one squamous cell carcinoma revealed bone destruction or erosion. Aggressive bone destruction and irregular enhancement were seen in eight cases of squamous cell carcinoma, seven cases of which showed involvement of the adjacent paranasal sinuses, nasopharynx, and orbit. Olfactory neuroblastomas were centered in the superior nasal cavity and the adjacent ethmoid sinus, and erosion or destruction of the cribriform plate had occurred. Lymphomas showed bilateral involvement, with uniform contrast enhancement. Polymorphic reticuloses showed perforation or erosion of the nasal septum, with bilateral involvement of the nasal cavity. The location, presence of bone destruction, involvement of adjacent structures, and enhancement pattern of tumor on CT can be helpful for the differential diagnosis of malignant nasal cavity tumors

1997-02-01

367

Skull invaders: when surgical pathology and neuropathology worlds collide.  

Science.gov (United States)

Skull and dura serve as effective barriers to penetration by most tumors, often preventing masses originating intracranially from extending into the contiguous bone and soft tissues, or those arising in head and neck regions from extending into the dura and brain tissue. We review our 15-year experience with extracranial tumors that had sufficiently invaded adjacent skull, dura, or brain from the "outside-in" to require a neurosurgeon to participate in the surgical resection and discuss our 40 cases in context with the literature. Sinonasal-origin tumors (n = 17) and cutaneous tumors (n = 10) were the most frequent skull-invaders. Most of the cutaneous tumor types were squamous cellcarcinomas (n = 9); diverse sinonasal-origin types included 4 squamous cell carcinomas, 4 adenoid cystic carcinomas, 2 sinonasal undifferentiated carcinomas, 2 sinonasal adenocarcinomas, and single examples each of sinonasal-origin hemangiopericytoma, solitary fibrous tumor, melanoma, mucocele, and teratocarcinoma. There were 9olfactory neuroblastomas, and middle ear-origin basal cell carcinoma,recurrent glomus jugulare, and orbital malignant hidradenoma were also seen. Unique tumors included a cutaneous cylindroma invasive of skull convexity occurring in familial cylindromatosis and a ganglioneuroma of the middle ear with massive bilateral skull base extension. Convexity dural spread, a seldom-reported pattern of dissemination, was seen in 1 olfactory neuroblastoma and 1 adenoid cystic carcinoma. The ability to show skull/dural invasion did not correlate with specific histopathologic features; even benign tumor types can show skull/dural penetration. PMID:23771219

Serracino, Hilary S; Kleinschmidt-Demasters, B K

2013-07-01

368

CT findings of malignant nasal cavity tumors  

Energy Technology Data Exchange (ETDEWEB)

To evaluate the CT findings of malignant nasal cavity tumors. Retrospective analysis was performed on 20 patients with pathologically-proven malignant nasal cavity tumors. Using CT, we analysed their location, extent of bone destruction and of involvement of adjacent structures, and enhancing pattern. A total of 20 cases included nine squamous cell carcinomas, three olfactory neuroblastomas, three lymphomas, two polymorphic reticulosis, one adenoid cystic carcinoma, one undifferentiated carcinoma and one metastasis from renal cell carcinoma. All cases except one adenoid cystic carcinoma and one squamous cell carcinoma revealed bone destruction or erosion. Aggressive bone destruction and irregular enhancement were seen in eight cases of squamous cell carcinoma, seven cases of which showed involvement of the adjacent paranasal sinuses, nasopharynx, and orbit. Olfactory neuroblastomas were centered in the superior nasal cavity and the adjacent ethmoid sinus, and erosion or destruction of the cribriform plate had occurred. Lymphomas showed bilateral involvement, with uniform contrast enhancement. Polymorphic reticuloses showed perforation or erosion of the nasal septum, with bilateral involvement of the nasal cavity. The location, presence of bone destruction, involvement of adjacent structures, and enhancement pattern of tumor on CT can be helpful for the differential diagnosis of malignant nasal cavity tumors.

Ku, Young Mi; Chun, Kyung Ah; Choi, Kyu Ho; Yu, Won Jong; Kim, Young Joo; Kim, Sung Hoon; Park, Seog Hee; Shinn, Kyung Sub [Catholic Univ. College of Medicine, Seoul (Korea, Republic of)

1997-02-01

369

Clinical investigation of malignant parotid tumors  

International Nuclear Information System (INIS)

We reviewed 55 cases of previously untreated malignant tumors arising in the parotid gland treated between Jan 1989 and May 2008. Histopathologically, we observed 13 tumor types, the most frequent histological type being mucoepidermoid carcinoma (12), followed by adenoid cystic carcinoma (11). According to clinical stage, 5 subjects were classified as T1, 18 as T2, 10 as T3, and 22 as T4. N+ cases numbered 7, and were staged as N2. Six had distant metastasis (5 lung and 1 axillary). Nineteen exhibited facial nerve palsy before treatment. Among major therapies, surgery was conducted in 50 subjects, radiation therapy in 3, and chemotherapy, and percutaneous ethanol injection therapy in each. Overall five-year survival determined using the Kaplan-Meier method was 73%. Among major histopathological types, five-year survival was 33% for undifferentiated carcinoma, 40% for adenocarcinoma, 62% for mucoepidermoid carcinoma, 67% for carcinoma in pleomorphic adenoma, and 100% for adenoid cystic carcinoma and acinic cell carcinoma. By T classification, five-year survival was 100% for T1, 88% for T2, 90% for T3, and 44% for T4. Five-year survival was 36% for those exhibiting facial nerve palsy and 94% for non palsy. Factors influencing poor outcome were T4 (p=0.001) and facial nerve palsy (p=0.001). (author)

2009-06-01

370

Primary tumors of the trachea. Results of radiation therapy  

International Nuclear Information System (INIS)

From 1959 to 1986, 24 patients with primary malignant tumors of the trachea received radiotherapy as all or part of treatment. Common presentations included respiratory symptoms in 20 patients and hemoptysis in 15. Thirteen patients had squamous carcinomas with undifferentiated and adenoid cystic cancers in five and four patients, respectively. Overall actuarial survival was 45% at 1 year, 25% at 5 years, and 13% at 10 years. Survival was significantly correlated to histologic type (adenoid cystic versus squamous, P less than 0.03), but not to tumor extent or to patient age or sex. Local control was attained in 10 of 24 patients overall and was more frequent for patients with tumors localized to the trachea and for patients who were treated with combined surgery and radiotherapy. For the 18 patients treated with radiotherapy alone, complete response (CR) was seen to be significantly (P less than 0.001) related to dose: six of seven (86%) patients receiving greater than or equal to 6000 cGy attained CR versus one of 11 (9%) receiving less than 6000 cGy. Three patients developed complications related to radiotherapy. Radiotherapy can provide durable local control of localized tracheal tumors and should be considered for medically inoperable patients with localized tumors and for patients with high risk of recurrence after resection

1989-06-15

371

Patterns of nodal relapse after surgery and postoperative radiation therapy for carcinomas of the major and minor salivary glands: What is the role of elective neck irradiation?  

International Nuclear Information System (INIS)

Purpose: To evaluate the incidence of nodal relapses from carcinomas of the salivary glands among patients with clinically negative necks in an attempt to determine the potential utility of elective neck irradiation (ENI). Methods and Materials: Between 1960 and 2004, 251 patients with clinically N0 carcinomas of the salivary glands were treated with surgery and postoperative radiation therapy. None of the patients had undergone previous neck dissection. Histology was: adenoid cystic (84 patients), mucoepidermoid (60 patients), adenocarcinoma (58 patients), acinic cell (21 patients), undifferentiated (11 patients), carcinoma ex pleomorphic adenoma (7 patients), squamous cell (7 patients), and salivary duct carcinoma (3 patients); 131 patients (52%) had ENI. Median follow-up was 62 months (range, 3-267 months). Results: The 5- and 10-year actuarial estimates of nodal relapse were 11% and 13%, respectively. The 10-year actuarial rates of nodal failure were 7%, 5%, 12%, and 16%, for patients with T1, T2, T3, and T4 disease, respectively (p = 0.11). The use of ENI reduced the 10-year nodal failure rate from 26% to 0% (p = 0.0001). The highest crude rates of nodal relapse among those treated without ENI were found in patients with squamous cell carcinoma (67%), undifferentiated carcinoma (50%), adenocarcinoma (34%), and mucoepidermoid carcinoma (29%). There were no nodal failures observed among patients with adenoid cystic or acinic cell histology. Conclusion: ENI effectively prevents nodal relapses and should be used for select patients at high risk for regional failure

2007-03-15

372

Salivary gland carcinoma in Denmark 1990-2005: a national study of incidence, site and histology. Results of the Danish Head and Neck Cancer Group (DAHANCA)  

DEFF Research Database (Denmark)

To describe the incidence, site and histology (WHO 2005) of salivary gland carcinomas in Denmark. Nine hundred and eighty-three patients diagnosed from 1990 to 2005 were identified from three nation-wide registries. The associated clinical data were retrospectively retrieved from patient medical records. Histological revision was performed in 886 cases (90%). Based on histological revision, 31 patients (3%) were excluded from the study leaving 952 for epidemiological analysis. The mean crude incidence in Denmark was 1.1/100,000/year. The male vs. female ratio was 0.97 and the median age was 62 years. The parotid gland was the most common site (52.5%) followed by the minor salivary glands of the oral cavity (26.3%). The most frequent histological subtypes were adenoid cystic carcinoma (25.2%), mucoepidermoid carcinoma (16.9%), adenocarcinoma NOS (12.2%) and acinic cell carcinoma (10.2%). The revision process changed the histological diagnosis in 121 out of 886 cases (14%). The incidence of salivary gland carcinoma in Denmark is higher than previously reported. More than half of salivary gland carcinomas are located in the parotid gland with adenoid cystic carcinoma being the most frequent subtype. Histological classification of salivary gland carcinomas is difficult and evaluation by dedicated pathology specialists might be essential for optimal diagnosis and treatment.

Bjørndal, Kristine; Krogdahl, Annelise

2011-01-01

373

Molar incisor hypomineralization, prevalence, and etiology.  

Science.gov (United States)

Aim. To evaluate the prevalence and possible etiological factors associated with molar incisor hypomineralization (MIH) among a group of children in Jeddah, Saudi Arabia. Methods. A group of 8-12-year-old children were recruited (n = 267) from the Pediatric Dental Clinics at the Faculty of Dentistry, King Abdulaziz University. Children had at least one first permanent molar (FPM), erupted or partially erupted. Demographic information, children's medical history, and pregnancy-related data were obtained. The crowns of the FPM and permanent incisors were examined for demarcated opacities, posteruptive breakdown (PEB), atypical restorations, and extracted FPMs. Children were considered to have MIH if one or more FPM with or without involvement of incisors met the diagnostic criteria. Results. MIH showed a prevalence of 8.6%. Demarcated opacities were the most common form. Maxillary central incisors were more affected than mandibular (P = 0.01). The condition was more prevalent in children with history of illnesses during the first four years of life including tonsillitis (P = 0.001), adenoiditis (P = 0.001), asthma (P = 0.001), fever (P = 0.014), and antibiotics intake (P = 0.001). Conclusions. The prevalence of MIH is significantly associated with childhood illnesses during the first four years of life including asthma, adenoid infections, tonsillitis, fever, and antibiotics intake. PMID:24949012

Allazzam, Sulaiman Mohammed; Alaki, Sumer Madani; El Meligy, Omar Abdel Sadek

2014-01-01

374

L-lysine in Treating Oral Mucositis in Patients Undergoing Radiation Therapy With or Without Chemotherapy For Head and Neck Cancer  

Science.gov (United States)

Mucositis; Oral Complications of Chemotherapy; Oral Complications of Radiation Therapy; Recurrent Adenoid Cystic Carcinoma of the Oral Cavity; Recurrent Basal Cell Carcinoma of the Lip; Recurrent Lymphoepithelioma of the Nasopharynx; Recurrent Lymphoepithelioma of the Oropharynx; Recurrent Mucoepidermoid Carcinoma of the Oral Cavity; Recurrent Salivary Gland Cancer; Recurrent Squamous Cell Carcinoma of the Hypopharynx; Recurrent Squamous Cell Carcinoma of the Larynx; Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity; Recurrent Squamous Cell Carcinoma of the Nasopharynx; Recurrent Squamous Cell Carcinoma of the Oropharynx; Recurrent Verrucous Carcinoma of the Larynx; Recurrent Verrucous Carcinoma of the Oral Cavity; Stage I Adenoid Cystic Carcinoma of the Oral Cavity; Stage I Basal Cell Carcinoma of the Lip; Stage I Lymphoepithelioma of the Nasopharynx; Stage I Lymphoepithelioma of the Oropharynx; Stage I Mucoepidermoid Carcinoma of the Oral Cavity; Stage I Salivary Gland Cancer; Stage I Squamous Cell Carcinoma of the Hypopharynx; Stage I Squamous Cell Carcinoma of the Larynx; Stage I Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage I Squamous Cell Carcinoma of the Nasopharynx; Stage I Squamous Cell Carcinoma of the Oropharynx; Stage I Verrucous Carcinoma of the Larynx; Stage I Verrucous Carcinoma of the Oral Cavity; Stage II Adenoid Cystic Carcinoma of the Oral Cavity; Stage II Basal Cell Carcinoma of the Lip; Stage II Lymphoepithelioma of the Nasopharynx; Stage II Lymphoepithelioma of the Oropharynx; Stage II Mucoepidermoid Carcinoma of the Oral Cavity; Stage II Salivary Gland Cancer; Stage II Squamous Cell Carcinoma of the Hypopharynx; Stage II Squamous Cell Carcinoma of the Larynx; Stage II Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage II Squamous Cell Carcinoma of the Nasopharynx; Stage II Squamous Cell Carcinoma of the Oropharynx; Stage II Verrucous Carcinoma of the Larynx; Stage II Verrucous Carcinoma of the Oral Cavity; Stage III Adenoid Cystic Carcinoma of the Oral Cavity; Stage III Basal Cell Carcinoma of the Lip; Stage III Lymphoepithelioma of the Nasopharynx; Stage III Lymphoepithelioma of the Oropharynx; Stage III Mucoepidermoid Carcinoma of the Oral Cavity; Stage III Salivary Gland Cancer; Stage III Squamous Cell Carcinoma of the Hypopharynx; Stage III Squamous Cell Carcinoma of the Larynx; Stage III Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage III Squamous Cell Carcinoma of the Nasopharynx; Stage III Squamous Cell Carcinoma of the Oropharynx; Stage III Verrucous Carcinoma of the Larynx; Stage III Verrucous Carcinoma of the Oral Cavity; Stage IV Adenoid Cystic Carcinoma of the Oral Cavity; Stage IV Basal Cell Carcinoma of the Lip; Stage IV Lymphoepithelioma of the Nasopharynx; Stage IV Lymphoepithelioma of the Oropharynx; Stage IV Mucoepidermoid Carcinoma of the Oral Cavity; Stage IV Salivary Gland Cancer; Stage IV Squamous Cell Carcinoma of the Hypopharynx; Stage IV Squamous Cell Carcinoma of the Larynx; Stage IV Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage IV Squamous Cell Carcinoma of the Nasopharynx; Stage IV Squamous Cell Carcinoma of the Oropharynx; Stage IV Verrucous Carcinoma of the Larynx; Stage IV Verrucous Carcinoma of the Oral Cavity

2013-05-15

375

Erlotinib Hydrochloride in Treating Patients With Previously Treated Non-Small Cell Lung Cancer, Head and Neck Cancer, or Esophageal Cancer and Precancerous Lesions of the Lung  

Science.gov (United States)

High-grade Salivary Gland Mucoepidermoid Carcinoma; Low-grade Salivary Gland Mucoepidermoid Carcinoma; Occult Non-small Cell Lung Cancer; Salivary Gland Acinic Cell Tumor; Salivary Gland Adenocarcinoma; Salivary Gland Adenoid Cystic Carcinoma; Salivary Gland Anaplastic Carcinoma; Salivary Gland Malignant Mixed Cell Type Tumor; Salivary Gland Poorly Differentiated Carcinoma; Salivary Gland Squamous Cell Carcinoma; Squamous Lung Dysplasia; Stage 0 Esophageal Cancer; Stage 0 Non-small Cell Lung Cancer; Stage I Adenoid Cystic Carcinoma of the Oral Cavity; Stage I Basal Cell Carcinoma of the Lip; Stage I Esthesioneuroblastoma of the Paranasal Sinus and Nasal Cavity; Stage I Inverted Papilloma of the Paranasal Sinus and Nasal Cavity; Stage I Lymphoepithelioma of the Nasopharynx; Stage I Lymphoepithelioma of the Oropharynx; Stage I Midline Lethal Granuloma of the Paranasal Sinus and Nasal Cavity; Stage I Mucoepidermoid Carcinoma of the Oral Cavity; Stage I Non-small Cell Lung Cancer; Stage I Salivary Gland Cancer; Stage I Squamous Cell Carcinoma of the Hypopharynx; Stage I Squamous Cell Carcinoma of the Larynx; Stage I Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage I Squamous Cell Carcinoma of the Nasopharynx; Stage I Squamous Cell Carcinoma of the Oropharynx; Stage I Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity; Stage I Verrucous Carcinoma of the Larynx; Stage I Verrucous Carcinoma of the Oral Cavity; Stage IA Esophageal Cancer; Stage IB Esophageal Cancer; Stage II Adenoid Cystic Carcinoma of the Oral Cavity; Stage II Basal Cell Carcinoma of the Lip; Stage II Esthesioneuroblastoma of the Paranasal Sinus and Nasal Cavity; Stage II Inverted Papilloma of the Paranasal Sinus and Nasal Cavity; Stage II Lymphoepithelioma of the Nasopharynx; Stage II Lymphoepithelioma of the Oropharynx; Stage II Midline Lethal Granuloma of the Paranasal Sinus and Nasal Cavity; Stage II Mucoepidermoid Carcinoma of the Oral Cavity; Stage II Non-small Cell Lung Cancer; Stage II Salivary Gland Cancer; Stage II Squamous Cell Carcinoma of the Hypopharynx; Stage II Squamous Cell Carcinoma of the Larynx; Stage II Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage II Squamous Cell Carcinoma of the Nasopharynx; Stage II Squamous Cell Carcinoma of the Oropharynx; Stage II Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity; Stage II Verrucous Carcinoma of the Larynx; Stage II Verrucous Carcinoma of the Oral Cavity; Stage IIA Esophageal Cancer; Stage IIB Esophageal Cancer; Stage III Adenoid Cystic Carcinoma of the Oral Cavity; Stage III Basal Cell Carcinoma of the Lip; Stage III Esthesioneuroblastoma of the Paranasal Sinus and Nasal Cavity; Stage III Inverted Papilloma of the Paranasal Sinus and Nasal Cavity; Stage III Lymphoepithelioma of the Nasopharynx; Stage III Lymphoepithelioma of the Oropharynx; Stage III Midline Lethal Granuloma of the Paranasal Sinus and Nasal Cavity; Stage III Mucoepidermoid Carcinoma of the Oral Cavity; Stage III Salivary Gland Cancer; Stage III Squamous Cell Carcinoma of the Hypopharynx; Stage III Squamous Cell Carcinoma of the Larynx; Stage III Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage III Squamous Cell Carcinoma of the Nasopharynx; Stage III Squamous Cell Carcinoma of the Oropharynx; Stage III Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity; Stage III Verrucous Carcinoma of the Larynx; Stage III Verrucous Carcinoma of the Oral Cavity; Stage IIIA Esophageal Cancer; Stage IIIA Non-small Cell Lung Cancer; Stage IIIB Esophageal Cancer; Stage IIIB Non-small Cell Lung Cancer; Stage IIIC Esophageal Cancer; Stage IV Adenoid Cystic Carcinoma of the Oral Cavity; Stage IV Basal Cell Carcinoma of the Lip; Stage IV Esophageal Cancer; Stage IV Esthesioneuroblastoma of the Paranasal Sinus and Nasal Cavity; Stage IV Inverted Papilloma of the Paranasal Sinus and Nasal Cavity; Stage IV Lymphoepithelioma of the Nasopharynx; Stage IV Lymphoepithelioma of the Oropharynx; Stage IV Midline Lethal Granuloma of the Paranasal Sinus and Nasal Cavity; Stage IV Mucoepidermoid Carc

2014-04-09

376

Carcinoma não medular familiar da tiróide / Familial nommedullary thyroid cancer  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese O carcinoma diferenciado da tiróide, papilífero ou folicular, origina-se da célula folicular tiroideana, sendo a neoplasia maligna mais freqüente desta glândula. Desde 1955 têm sido relatados casos de agrupamento familiar deste carcinoma, e atualmente estima-se que 4,2% de todos os carcinomas difere [...] nciados da tiróide tenham origem familiar. Esses casos costumam ser mais agressivos, incidem em idade mais precoce, são multifocais e apresentam maior taxa de recorrência. Parecem ser transmitidos por herança autossômica dominante com penetrância variável, mas os genes exatos responsáveis pela doença ainda não foram totalmente identificados. Os pacientes devem ser tratados com tiroidectomia total e freqüentemente também com esvaziamento linfonodal cervical, seguidos de ablação com iodo radioativo e terapia supressiva do TSH com levotiroxina. Alguns autores recomendam rastreamento de familiares de primeiro grau dos pacientes afetados através da ultrassonografia cervical, com objetivo de realizar diagnóstico precoce, possibilitando melhores resultados terapêuticos. Abstract in english Nonmedullary thyroid carcinoma, originating from thyroid epithelial cells, is the most frequent thyroid malignant neoplasia. Since 1955, there has been increasing evidence that this cancer may have a familial predisposition. It is now established that around 4.2% of all nonmedullary thyroid carcinom [...] as occurs on the background of familial predisposition. These cases are often more aggressive, due to early onset, multifocality and a higher percentual of recurrences. An autossomal dominant inheritance pattern appears likely in most families, although the exact genes responsible for this syndrome have not yet been identified. Patients affected by this cancer should be treated with total thyroidectomy routinely and, in most cases, lymph node dissection, followed by iodine ablation and TSH suppressive therapy with levothyroxine. Some authors also recommend that first-degree relatives of patients with nonmedullary thyroid cancer (especially women) should be submitted to neck ultrasound for thyroid cancer screening, aiming early diagnosis for better treatment results.

Roberto Bernardo, Santos; Thaís Gomes de, Melo; Lígia V. Montali, Assumpção.

377

Rationale for the real-time and dynamic cell death assays using propidium iodide.  

Science.gov (United States)

We have recently reported an innovative approach to use charged fluorochromes such as propidium iodide (PI) in the real-time, dynamic cell viability assays. This study was designed to provide a mechanistic rationale for the kinetic assays using cell permeability markers. Uptake of PI by live cells, effect on the cell cycle, long-term proliferation capacity, DNA damage response, and pharmacologic interactions with anticancer drugs were studied using both laser scanning microscopy and laser scanning cytometry. Exposure of human carcinomic alveolar basal epithelial A549 cells in cultures to 1.5 or 7.5 microM of PI for 24 h had minimal effect on cell cycle progression including DNA replication as measured by incorporation of 5'-ethynyl-2-deoxyuridine (EdU) detected by the "click chemistry" approach and measured by laser scanning cytometry. A modest reduction, from 44 to 40% or 33%, in frequency of DNA replicating cells was seen after 48 h at 1.5 or 7.5 microM concentration of PI. There was no evidence of increased phosphorylation of histone gammaH2AX in cells growing in the presence of 1.5 or 7.5 microM of PI for up to 48 h. Confocal image analysis of HeLa and NIH 3T3 mouse embryonic fibroblasts growing in the presence of PI showed granular distribution in cell cytoplasm suggesting PI accumulation in endosomes and progressive increase in fluorescence of nucleoli reflecting PI binding to nucleolar RNA. The overall responses of cells to cytotoxic agents were also not affected by the growth in the presence PI. Our data lend further support to the notion that PI can be effectively used in real-time, kinetic viability assays. PMID:20131407

Zhao, Hong; Oczos, Jadwiga; Janowski, Pawel; Trembecka, Dominika; Dobrucki, Jurek; Darzynkiewicz, Zbigniew; Wlodkowic, Donald

2010-04-01

378

Impact of thawing on reference gene expression stability in renal cell carcinoma samples.  

Science.gov (United States)

More and more samples are obtained from biobanks for biomedical research; however, some of these samples may undergo thawing before processing. We aim to evaluate the reference gene expression stability in thawed renal cell carcinoma samples. Sixteen matched malignant and nonmalignant renal tissue samples were obtained and each sample was divided into 4 aliquots before being snap frozen and stored at -80°C. By quantitative real-time polymerase chain reaction, a time-course study was conducted on the thawed tissue to evaluate the expression stability of a panel of the 10 most frequently used reference genes in renal cell carcinom samples: ACTB, ALAS1, B2M, GAPDH, HMBS, HPRT, PPIA, RPLP0,TBP, and TUBB. As shown by geNorm M values, PPIA was the most stable gene at the 0-, 15-, and 30-minute time points (M=0.82, 0.85, and 0.76, respectively), whereas GAPDH was ranked last at the 5-, 15-, and 30-minute time points (M=1.38, 1.44, and 1.39, respectively). A positive correlation was found by linear regression between the thawing time and 2 to the power of crossing point values of all candidate reference genes (Pcoefficient of variance of all reference genes increased significantly at time points 5, 15, and 30 minutes compared with 0 minutes (P<0.01). In conclusion, using the geNorm algorithm, PPIA was identified as the most stably expressed gene between malignant and nonmalignant renal tissue samples that were thawed for similar time periods. All the reference genes showed high variations along with the thawing time; it should be recommended to use a combination of several candidate reference genes when comparing samples thawed for different time periods. PMID:22847160

Ma, Yi; Dai, HuiLi; Kong, XianMing; Wang, LiMin

2012-09-01

379

Las 47 preguntas sobre el virus del papiloma humano, VPH  

Scientific Electronic Library Online (English)

Full Text Available SciELO Spain | Language: Spanish Abstract in spanish La prevención del cáncer de cuello uterino ha evolucionado rápidamente a consecuencia de la identificación de su causa, el Virus del Papiloma Humano (VPH). La asociación VPH/Cáncer de Cuello Uterino, es aplicable tanto al carcinoma escamocelular como al adenocarcinoma. Dos de los tipos oncogénicos, [...] los VPHs 16 y 18, son responsables del 70% de los casos de cáncer de cuello uterino a nivel mundial. El VPH es muy prevalente entre personas sexualmente activas, y se puede identificar fácilmente mediante el uso de tecnologías capaces de detectar ADN y otros biomarcadores del VPH. El ADN y los biomarcadores se pueden detectar en todas las fases de la historia natural de la infección y del proceso neoplásico. Dicha trazabilidad unida a la validación clínica de las tecnologías de identificación, han permitido mejorar los protocolos de cribado del cáncer cervical. La proteína principal del virión, ya expresada, produce inmunógenos capaces de inducir fuertes respuestas inmunitarias cuando se administran vía intramuscular, y ésta es la base de la Vacuna frente a VPH. Abstract in english The UCC (Uterine Cervical Cancer) prevention has suffered a great evolution because of the knowing of its cause, wich is the HPV (Human Papillomavirus). The association HPV / UCC is available also to Scamocellular Carcinome to Adenocarcinome. Mundially, the oncogenic types, 16 and 18, are responssib [...] le of 70% of cases of UCC. HPV is very prevalent in sexually active people, and it’s easy identify by using DNA amplyfiyng technologies and other biomarkers. These ones can be detected in hole virus natural life, including the neoplasic process. The tazability and the clinic validation of this technologies, have improved to get a better screening of the UCC. The main HPV protein, is able to produce a strong inmunitary response, when it’s given by intramuscular punctury; and this is the explanation of the HPC vaccine.

Elena de la, Fuente Díez; Luz María, Mira Ferrer.

380

Las 47 preguntas sobre el virus del papiloma humano, VPH  

Directory of Open Access Journals (Sweden)

Full Text Available La prevención del cáncer de cuello uterino ha evolucionado rápidamente a consecuencia de la identificación de su causa, el Virus del Papiloma Humano (VPH. La asociación VPH/Cáncer de Cuello Uterino, es aplicable tanto al carcinoma escamocelular como al adenocarcinoma. Dos de los tipos oncogénicos, los VPHs 16 y 18, son responsables del 70% de los casos de cáncer de cuello uterino a nivel mundial. El VPH es muy prevalente entre personas sexualmente activas, y se puede identificar fácilmente mediante el uso de tecnologías capaces de detectar ADN y otros biomarcadores del VPH. El ADN y los biomarcadores se pueden detectar en todas las fases de la historia natural de la infección y del proceso neoplásico. Dicha trazabilidad unida a la validación clínica de las tecnologías de identificación, han permitido mejorar los protocolos de cribado del cáncer cervical. La proteína principal del virión, ya expresada, produce inmunógenos capaces de inducir fuertes respuestas inmunitarias cuando se administran vía intramuscular, y ésta es la base de la Vacuna frente a VPH.The UCC (Uterine Cervical Cancer prevention has suffered a great evolution because of the knowing of its cause, wich is the HPV (Human Papillomavirus. The association HPV / UCC is available also to Scamocellular Carcinome to Adenocarcinome. Mundially, the oncogenic types, 16 and 18, are responssible of 70% of cases of UCC. HPV is very prevalent in sexually active people, and it’s easy identify by using DNA amplyfiyng technologies and other biomarkers. These ones can be detected in hole virus natural life, including the neoplasic process. The tazability and the clinic validation of this technologies, have improved to get a better screening of the UCC. The main HPV protein, is able to produce a strong inmunitary response, when it’s given by intramuscular punctury; and this is the explanation of the HPC vaccine.

Elena de la Fuente Díez

2008-09-01

 
 
 
 
381

Les tumeurs malignes primitives de l’intestin grèle: Aspects cliniques et thérapeutiques de 27 patients  

Directory of Open Access Journals (Sweden)

Full Text Available Les tumeurs malignes de l'intestin grèle (TMPIG sont des tumeurs rares. Elles représentent 1 à 5% de toutes les tumeurs du tube digestif. Elles sont caractérisées par une hétérogénéité anatomopathologique et une symptomatologie pauvre et non spécifique entrainant ainsi un retard diagnostic, des difficultés Thérapeutiques et donc un mauvais pronostic. Nous rapportant les caractéristiques épidémiologiques, diagnostiques et thérapeutiques ainsi que la survie des patients atteints des TMIG au sein de l’institut national d’oncologie de Rabat. Il s’agit d’une analyse rétrospective des dossiers cliniques des 27 patients ayant le diagnostic de tumeurs malignes de l’intestin grèle admis dans notre institut entre 1998 et 2002. L’âge médian était de 46 ans (15-70 ans. Le délai médian de diagnostic était de 6 mois (0-96 mois. La douleur abdominale était le symptôme le plus fréquent (77.8%. L’étude anatomopathologique a montré 63% de lymphome non Hodgkinie, 14.8% d’adénocarcinome, 7.4% de tumeur stromale, 7.4% de carcinome neuroendocrine et 7.4% de sarcome intestinal. Vingt patients (76. 9% ont eu une résection chirurgicale et 14 patients (53. 8% ont eu une chimiothérapie en fonction du stade de la maladie et du type histologique. Après un recul médian de 11.6 mois, la survie globale après 12 mois était de 44.4% et la médiane de survie était de 11.6 mois. Les tumeurs malignes de l’intestin grèle sont rares. Leur diagnostic est tardif limitant ainsi la prise en charge thérapeutique curative. Les cliniciens doivent ètre avertis des symptômes gastro-intestinaux non spécifiques

Abahssain Halima

2011-03-01

382

R?le de la cystoscopie de fluorescence en lumi?re bleue induite par Hexvix dans la prise en charge des tumeurs uroth?liales v?sicales  

Science.gov (United States)

Résumé Objectifs : Évaluer la faisabilité, la fiabilité, le rôle actuel et l’intérêt de la cystoscopie de fluorescence en lumière bleue induite par l’hexaminolévulinate (Hexvix, Photocure ASA) pour la détection des tumeurs urothéliales. Préciser le profil des tumeurs plus particulièrement concernées par cette technique. Patients et méthodes : De janvier 2009 à janvier 2010, une lésion vésicale papillaire typique ou une lésion suspecte a été décelée en cystoscopie chez un total de 30 patients (64 prélèvements). Une résection endoscopique a été réalisée après la détection des lésions vésicales en lumière blanche et en lumière bleue (Hexvix). Une limite de l’étude est l’utilisation répétée d’Hexvix aux fins du suivi de patients porteurs d’un cancer de la vessie n’a pas été étudiée. Résultats : L’âge moyen des patients était de 70 ans (56–84 ans ; 27 hommes et 3 femmes). La cytologie préopératoire s’est révélée positive chez 17 patients, et négative chez 13 patients. Notre étude de 30 patients a permis d’analyser 64 prélèvements. Trente-cinq tumeurs papillaires et 10 lésions non papillaires, mais suspectes, ont été repérées en lumière blanche. Cinquante-six prélèvements présentaient une fluorescence positive en lumière bleue, dont 19 lésions étaient seulement décelables sous cette source de lumière. Conclusion : Notre étude nous a permis de conclure que la cystoscopie de fluorescence à l’hexaminolévulinate améliore sensiblement la détection des tumeurs superficielles de la vessie, particulièrement des carcinomes in situ (CIS). De plus, elle permet une résection plus complète qu’en cystoscopie standard à la lumière blanche et diminue le taux de tumeurs résiduelles après résection transurétrale de la vessie (RTUV).

Sakel, Adil Ait; Mazdar, Adil; N'guibou, Faustin

2014-01-01

383

Selective anticancer effects of a synthetic flavagline on human Oct4-expressing cancer stem-like cells via a p38 MAPK-dependent caspase-3-dependent pathway.  

Science.gov (United States)

Cancer stem cells (CSCs) are considered as the initiators of the carcinogenic process and are therefore emerging targets for innovative anticancer therapies. In order to evaluate the anticancer chemopreventive activity of flavagline derivatives, we used the pluripotent teratocarcinomal cell as a model of Oct4-expressing cancer stem-like cell and determined the underlying cellular and molecular mechanisms induced by a synthetic flavagline. We precisely investigated the effects of the flavagline derivative FL3 on the human embryonal carcinoma (EC) cell line NT2/D1 and compared the responses to those of a normal more restrictive pluripotent stem cell line (i.e. BJ fibroblast cell line). FL3 selectively inhibited the proliferation of NT2/D1 cells by inducing G1 phase cell cycle arrest in a dose-dependent manner. Moreover, FL3 treatment specifically triggered apoptosis in association with an induction of the phosphorylation of p38 mitogen-activated protein kinase (MAPK) and caspase-3 activation followed by a drastic downregulation of the master regulator of stemness Oct4. Forced inhibition of p38 MAPK activity by the specific pharmacological inhibitor SB203580 or by p38 MAPK gene knockdown using small-interfering RNA (siRNA) counteracted the effects of FL3, demonstrating that its chemopreventive action is related to growth inhibition and a p38-dependent caspase-3-dependent induction of apoptosis in Oct4-expressing CSCs. This study also shows that FL3 selectively kills poorly differentiated and highly aggressive carcinomal cells, but has little effect on normal stem-like cells. Thus FL3 offers great promise for cancer treatment since it is able to target the carcinogenic process without affecting normal cells. PMID:24607276

Emhemmed, Fathi; Ali Azouaou, Sarah; Thuaud, Frédéric; Schini-Kerth, Valérie; Désaubry, Laurent; Muller, Christian D; Fuhrmann, Guy

2014-05-15

384

Value and indication of radiotherapy in the endometrical carcinoma. Wert und Indikation der Strahlentherapie beim Endometriumkarzinom  

Energy Technology Data Exchange (ETDEWEB)

Today the endometrial carcinoma is the most frequent malignant tumor found in female genital tract. Endometrial carcinoma ought to be operated in all cases, if possible. Traditionally some form of adjuvant radiotherapy has been given. Despite the large number of patients treated by combined therapy over the last 30 years, surprisingly there is a lack of hard data on which to establish a theory for an improved outcome. It is generally accepted that the risk of local relapses in the vagina is lowered when postoperative vaginal irradiation is applied. The question of the value of additional external irradiation in stage I endometrial cancer still is unsetteled. Only two prospective studies led to the conclusion that only patients with poorly differentiated tumors and with deep infiltration of the myometrium might benefit from additional external radiotherapy. Therefore a simple score for these risk factors is proposed enabling assignment into patient groups of similar risk on the base of a point system due to individual prognostic factors. With a score of one to two points prognosis is very good and adjuvant irradiation seems not to be necessary. With three to four points local vaginal irradiation is recommended, with five and more points additionally external beam irradiation to the pelvis should be given. This is necessary in more than the half of the operated cases of endometrial carcinoma. The indication for such a treatment has become more individual and 'high risk' cases are treated more intensively, but 'low risk' cases have to be excepted from unnecessary adjuvant therapy. In order to judge an individual case of endometrial cancer histopathologic prognosticators have to be considered. Typical adenocarcinomas have a five-year survival of more than 80%, but unfavourable subtypes (adenosquamous, clearcell, serous-papillary carcinoms) of only 40%, respectively. Tumorgrading and depth of myometrial invasion are of high importance for individual prognosis.

Kucera, H. (Vienna Univ. (Austria). Strahlenabteilung der 1. und 2. Frauenklinik)

1991-07-01

385

Value and indication of radiotherapy in the endometrical carcinoma  

International Nuclear Information System (INIS)

Today the endometrial carcinoma is the most frequent malignant tumor found in female genital tract. Endometrial carcinoma ought to be operated in all cases, if possible. Traditionally some form of adjuvant radiotherapy has been given. Despite the large number of patients treated by combined therapy over the last 30 years, surprisingly there is a lack of hard data on which to establish a theory for an improved outcome. It is generally accepted that the risk of local relapses in the vagina is lowered when postoperative vaginal irradiation is applied. The question of the value of additional external irradiation in stage I endometrial cancer still is unsetteled. Only two prospective studies led to the conclusion that only patients with poorly differentiated tumors and with deep infiltration of the myometrium might benefit from additional external radiotherapy. Therefore a simple score for these risk factors is proposed enabling assignment into patient groups of similar risk on the base of a point system due to individual prognostic factors. With a score of one to two points prognosis is very good and adjuvant irradiation seems not to be necessary. With three to four points local vaginal irradiation is recommended, with five and more points additionally external beam irradiation to the pelvis should be given. This is necessary in more than the half of the operated cases of endometrial carcinoma. The indication for such a treatment has become more individual and 'high risk' cases are treated more intensively, but 'low risk' cases have to be excepted from unnecessary adjuvant therapy. In order to judge an individual case of endometrial cancer histopathologic prognosticators have to be considered. Typical adenocarcinomas have a five-year survival of more than 80%, but unfavourable subtypes (adenosquamous, clearcell, serous-papillary carcinoms) of only 40%, respectively. Tumorgrading and depth of myometrial invasion are of high importance for individual prognosis. (orig./MG)

1991-01-01

386

Photodynamic Therapy Using HPPH in Treating Patients Undergoing Surgery for Primary or Recurrent Head and Neck Cancer  

Science.gov (United States)

Recurrent Adenoid Cystic Carcinoma of the Oral Cavity; Recurrent Basal Cell Carcinoma of the Lip; Recurrent Esthesioneuroblastoma of the Paranasal Sinus and Nasal Cavity; Recurrent Inverted Papilloma of the Paranasal Sinus and Nasal Cavity; Recurrent Lymphoepithelioma of the Nasopharynx; Recurrent Lymphoepithelioma of the Oropharynx; Recurrent Metastatic Squamous Neck Cancer With Occult Primary; Recurrent Midline Lethal Granuloma of the Paranasal Sinus and Nasal Cavity; Recurrent Mucoepidermoid Carcinoma of the Oral Cavity; Recurrent Salivary Gland Cancer; Recurrent Squamous Cell Carcinoma of the Hypopharynx; Recurrent Squamous Cell Carcinoma of the Larynx; Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity; Recurrent Squamous Cell Carcinoma of the Nasopharynx; Recurrent Squamous Cell Carcinoma of the Oropharynx; Recurrent Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity; Recurrent Thyroid Cancer; Recurrent Verrucous Carcinoma of the Larynx; Recurrent Verrucous Carcinoma of the Oral Cavity; Stage I Adenoid Cystic Carcinoma of the Oral Cavity; Stage I Basal Cell Carcinoma of the Lip; Stage I Esthesioneuroblastoma of the Paranasal Sinus and Nasal Cavity; Stage I Follicular Thyroid Cancer; Stage I Inverted Papilloma of the Paranasal Sinus and Nasal Cavity; Stage I Lymphoepithelioma of the Nasopharynx; Stage I Lymphoepithelioma of the Oropharynx; Stage I Midline Lethal Granuloma of the Paranasal Sinus and Nasal Cavity; Stage I Mucoepidermoid Carcinoma of the Oral Cavity; Stage I Papillary Thyroid Cancer; Stage I Salivary Gland Cancer; Stage I Squamous Cell Carcinoma of the Hypopharynx; Stage I Squamous Cell Carcinoma of the Larynx; Stage I Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage I Squamous Cell Carcinoma of the Oropharynx; Stage I Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity; Stage I Verrucous Carcinoma of the Larynx; Stage I Verrucous Carcinoma of the Oral Cavity; Stage II Adenoid Cystic Carcinoma of the Oral Cavity; Stage II Basal Cell Carcinoma of the Lip; Stage II Esthesioneuroblastoma of the Paranasal Sinus and Nasal Cavity; Stage II Follicular Thyroid Cancer; Stage II Inverted Papilloma of the Paranasal Sinus and Nasal Cavity; Stage II Lymphoepithelioma of the Nasopharynx; Stage II Lymphoepithelioma of the Oropharynx; Stage II Midline Lethal Granuloma of the Paranasal Sinus and Nasal Cavity; Stage II Mucoepidermoid Carcinoma of the Oral Cavity; Stage II Papillary Thyroid Cancer; Stage II Salivary Gland Cancer; Stage II Squamous Cell Carcinoma of the Hypopharynx; Stage II Squamous Cell Carcinoma of the Larynx; Stage II Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage II Squamous Cell Carcinoma of the Oropharynx; Stage II Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity; Stage II Verrucous Carcinoma of the Larynx; Stage II Verrucous Carcinoma of the Oral Cavity

2014-01-14

387

Bevacizumab, Fluorouracil, and Hydroxyurea Plus Radiation Therapy in Treating Patients With Advanced Head and Neck Cancer  

Science.gov (United States)

Metastatic Squamous Neck Cancer With Occult Primary Squamous Cell Carcinoma; Recurrent Adenoid Cystic Carcinoma of the Oral Cavity; Recurrent Basal Cell Carcinoma of the Lip; Recurrent Esthesioneuroblastoma of the Paranasal Sinus and Nasal Cavity; Recurrent Inverted Papilloma of the Paranasal Sinus and Nasal Cavity; Recurrent Lymphoepithelioma of the Nasopharynx; Recurrent Lymphoepithelioma of the Oropharynx; Recurrent Metastatic Squamous Neck Cancer With Occult Primary; Recurrent Midline Lethal Granuloma of the Paranasal Sinus and Nasal Cavity; Recurrent Mucoepidermoid Carcinoma of the Oral Cavity; Recurrent Salivary Gland Cancer; Recurrent Squamous Cell Carcinoma of the Hypopharynx; Recurrent Squamous Cell Carcinoma of the Larynx; Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity; Recurrent Squamous Cell Carcinoma of the Nasopharynx; Recurrent Squamous Cell Carcinoma of the Oropharynx; Recurrent Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity; Recurrent Verrucous Carcinoma of the Larynx; Recurrent Verrucous Carcinoma of the Oral Cavity; Stage III Adenoid Cystic Carcinoma of the Oral Cavity; Stage III Basal Cell Carcinoma of the Lip; Stage III Esthesioneuroblastoma of the Paranasal Sinus and Nasal Cavity; Stage III Inverted Papilloma of the Paranasal Sinus and Nasal Cavity; Stage III Lymphoepithelioma of the Nasopharynx; Stage III Lymphoepithelioma of the Oropharynx; Stage III Midline Lethal Granuloma of the Paranasal Sinus and Nasal Cavity; Stage III Mucoepidermoid Carcinoma of the Oral Cavity; Stage III Salivary Gland Cancer; Stage III Squamous Cell Carcinoma of the Hypopharynx; Stage III Squamous Cell Carcinoma of the Larynx; Stage III Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage III Squamous Cell Carcinoma of the Nasopharynx; Stage III Squamous Cell Carcinoma of the Oropharynx; Stage III Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity; Stage III Verrucous Carcinoma of the Larynx; Stage III Verrucous Carcinoma of the Oral Cavity; Stage IV Adenoid Cystic Carcinoma of the Oral Cavity; Stage IV Basal Cell Carcinoma of the Lip; Stage IV Esthesioneuroblastoma of the Paranasal Sinus and Nasal Cavity; Stage IV Inverted Papilloma of the Paranasal Sinus and Nasal Cavity; Stage IV Lymphoepithelioma of the Nasopharynx; Stage IV Lymphoepithelioma of the Oropharynx; Stage IV Midline Lethal Granuloma of the Paranasal Sinus and Nasal Cavity; Stage IV Mucoepidermoid Carcinoma of the Oral Cavity; Stage IV Salivary Gland Cancer; Stage IV Squamous Cell Carcinoma of the Hypopharynx; Stage IV Squamous Cell Carcinoma of the Larynx; Stage IV Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage IV Squamous Cell Carcinoma of the Nasopharynx; Stage IV Squamous Cell Carcinoma of the Oropharynx; Stage IV Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity; Stage IV Verrucous Carcinoma of the Larynx; Stage IV Verrucous Carcinoma of the Oral Cavity; Untreated Metastatic Squamous Neck Cancer With Occult Primary

2013-02-06

388