WorldWideScience
 
 
1

Adenoid cystic carcinoma of the breast; Carcinome adenoide kystique du sein  

Energy Technology Data Exchange (ETDEWEB)

Adenoid cystic carcinoma of the breast is a rare neoplasm, accounting for only 0.1% of all malignant breast tumours. It is more common in women in the sixth decade of their lives and often in the sub areolar area. The clinical criteria is not specific and the radiographic examination showed a benign-appearing tumour. The preoperative diagnosis is possible with fine-needle aspiration cytology. The diagnosis is made by histological examination, presented a difficult differential diagnosis with cribriform carcinoma; so it is necessary to use histochemical or immunohistochemical techniques. The treatment is not well established. It consists of lumpectomy with radiation or mastectomy. Compared to other locations, adenoid cystic carcinoma of the breast has a favorable prognosis. Lymph node involvement or distant metastases seldom occur. The aim of our study is to describe the epidemiological, clinico pathological characteristics, the treatment and the prognosis of this rare type of breast tumour. (authors)

Kallel, R.; Bahri Zouari, I.; Gouiaa, N.; Charfi, S.; Ayadi, L.; Makni, S.; Sellami Boudawara, T. [CHU Habib-Bourguiba, Lab. d' Anatomie et de Cytologie Pathologiques, Sfax (Tunisia); Daoud, E. [CHU Habib Bourguiba, Service de Radiologie, Sfax (Tunisia); Daoud, J. [CHU Habib Bourguiba, Service de Radiotherapie, Sfax (Tunisia)

2009-07-15

2

Literature review on the role of radiotherapy in the treatment of nasopharyngeal cystic adenoid carcinomas about two cases; Revue de la litterature sur la place de la radiotherapie dans le traitement des carcinomes adenoides kystiques du nasopharynx a propos de deux cas  

Energy Technology Data Exchange (ETDEWEB)

The authors discuss the characteristics and the radiotherapy treatment procedures of cystic adenoid carcinomas, and more precisely the treatment of two of such cases of nasopharyngeal carcinomas. The first one had an incomplete resection surgery followed by curing radiotherapy: he has then been in local-regional control situation for 8 months. The second one had lung metastases, was treated chemotherapy and radiotherapy (decompressive treatment), and died six months after diagnosis. Radiotherapy is considered to be the treatment basis, whereas chemotherapy is a matter of controversy. Short communication

Hemmich, M.; Hassouni, K.; Elkacemi, H.; Errachdi, A.; Mouhajir, N.; Zaidi, H.; Benjaafar, N. [Institut national d' oncologie, Rabat (Morocco)

2011-10-15

3

Fibrose kystique atypique  

Science.gov (United States)

Résumé Objectif Passer en revue le diagnostic des patients atteints de fibrose kystique (FK) atypique. Sources des données On a procédé à une recension exhaustive dans MEDLINE (de 1950 à la troisième semaine de mai 2009), dans MEDLINE In-Process and Other Non-Indexed Citations and Cases (de 1950 à la troisième semaine de 2009) et dans EMBASE (de 1980 à la quatrième semaine de mars 2009). On a aussi passé en revue le site web de Fibrose kystique Canada et on a consulté son plus récent rapport des inscriptions de données sur les patients. Message principal La FK atypique est une forme moins intense du trouble de la FK, qui est associée à des mutations du gène régulateur de la conductance transmembranaire de la fibrose kystique. Au lieu d’avoir les symptômes classiques, les personnes atteintes d’une FK atypique pourraient avoir une légère dysfonction d’un seul système organique et avoir ou non des concentrations de chlorure élevées dans la sueur. La FK atypique est un trouble très diversifié affectant différents systèmes organiques à divers degrés. Les symptômes du patient peuvent aussi fluctuer avec le temps; par ailleurs, certains signes et symptômes cliniques touchant les systèmes respiratoire, gastro-intestinal, endocrinien et métabolique et génito-urinaire devraient signaler aux médecins la possibilité d’une FK. Les patients atteints d’une FK atypique ont moins d’hospitalisations durant l’enfance que ceux qui ont une FK classique et le diagnostic peut passer inaperçu pendant de nombreuses années, parfois même jusqu’à l’âge adulte. Conclusion Même si les patients atteints d’une FK atypique ont une espérance de vie plus longue que les personnes atteintes de la forme classique, les issues à long terme pour de nombreuses personnes qui ont la forme atypique sont inconnues. Il est important de conseiller les patients à propos de la possibilité d’une manifestation future de la maladie. Renseigner les patients à propos de la FK peut les aider à comprendre leurs symptômes, à modifier leur mode de vie pour optimiser leur santé, à réduire l’incidence des complications et à recevoir au besoin du counseling sur la planification familiale.

Schram, Carrie A.

2012-01-01

4

Pneumatose kystique iléale révélée par un volvulus du grêle  

Directory of Open Access Journals (Sweden)

Full Text Available La pneumatose kystique intestinale est une pathologie rare qui se caractérise par la présence de kystes gazeux dans la paroi intestinale. Elle est asymptomatique ou pauci symptomatique, et le plus souvent découverte lors d’un examen d’imagerie ou d’endoscopie. Nous rapportons un cas de pneumatose iléale compliquée d’un volvulus sur bride chez un patient jamais opéré auparavant.

Hicham El bouhaddouti; Abdelmalek Ousadden; El Bachir Benjelloun; Karim Ibn Majdoub; Khalid Mazaz; Khalid Aït Taleb

2010-01-01

5

Fibrose kystique atypique: Identification en milieu de soins primaires.  

UK PubMed Central (United Kingdom)

RésuméObjectifPasser en revue le diagnostic des patients atteints de fibrose kystique (FK) atypique.Sources des donnéesOn a procédé à une recension exhaustive dans MEDLINE (de 1950 à la troisième semaine de mai 2009), dans MEDLINE In-Process and Other Non-Indexed Citations and Cases (de 1950 à la troisième semaine de 2009) et dans EMBASE (de 1980 à la quatrième semaine de mars 2009). On a aussi passé en revue le site web de Fibrose kystique Canada et on a consulté son plus récent rapport des inscriptions de données sur les patients.Message principalLa FK atypique est une forme moins intense du trouble de la FK, qui est associée à des mutations du gène régulateur de la conductance transmembranaire de la fibrose kystique. Au lieu d’avoir les symptômes classiques, les personnes atteintes d’une FK atypique pourraient avoir une légère dysfonction d’un seul système organique et avoir ou non des concentrations de chlorure élevées dans la sueur. La FK atypique est un trouble très diversifié affectant différents systèmes organiques à divers degrés. Les symptômes du patient peuvent aussi fluctuer avec le temps; par ailleurs, certains signes et symptômes cliniques touchant les systèmes respiratoire, gastro-intestinal, endocrinien et métabolique et génito-urinaire devraient signaler aux médecins la possibilité d’une FK. Les patients atteints d’une FK atypique ont moins d’hospitalisations durant l’enfance que ceux qui ont une FK classique et le diagnostic peut passer inaperçu pendant de nombreuses années, parfois même jusqu’à l’âge adulte.ConclusionMême si les patients atteints d’une FK atypique ont une espérance de vie plus longue que les personnes atteintes de la forme classique, les issues à long terme pour de nombreuses personnes qui ont la forme atypique sont inconnues. Il est important de conseiller les patients à propos de la possibilité d’une manifestation future de la maladie. Renseigner les patients à propos de la FK peut les aider à comprendre leurs symptômes, à modifier leur mode de vie pour optimiser leur santé, à réduire l’incidence des complications et à recevoir au besoin du counseling sur la planification familiale.

Schram CA

2012-12-01

6

Adenoid cystic carcinoma of palate.  

UK PubMed Central (United Kingdom)

Adenoid cystic carcinoma is a rare tumor arising from the minor salivary glands;, the palate being the commonest site. Distant metastasis and perineural invasion areis common in adenoid cystic carcinoma. Diagnosis of adenoid cystic carcinoma is made usually with the help of clinical features, radiographic features and histologic features. We reported a case of adenoid cystic carcinoma of palate involving left maxillary sinus. The diagnosis of the case and brief review of literature of adenoid cystic carcinoma is discussed. The aim here is to highlight the importance of diagnosis, treatment and long-term follow-up of the patients with adenoid cystic carcinoma.

Mehta DN; Parikh SJ

2013-01-01

7

Grading adenoid utilizing flexible nasopharyngoscopy.  

UK PubMed Central (United Kingdom)

BACKGROUND AND OBJECTIVES: To assess the possibility of adenoid size asymmetry in both nasal sides by nasopharyngoscopy. DESIGN AND SETTINGS: This is a prospective study involving 100 children, with age ranging between 1 and 12 years, performed in Saudi Arabia between January 2010 and December 2011. METHODS: Adenoid was examined and graded I-IV in relation to posterior choana bilaterally by flexible nasopharyngoscopy. The adenoid grade was compared with the other side in each child. RESULTS: The findings from endoscopy were analyzed: there was a high degree of agreement in grading both sides, that was 92% with kappa=0.868. Moreover, there was grade asymmetry in 8% of the cases. CONCLUSION: Adenoid grading using flexible nasopharyngoscopy through one side of the nose may not represent the adenoid grade of the other side in all cases.

Al-Ammar AY; Shebib D; Bokhari M; Jomah M

2013-05-01

8

Presence of herpesviruses in adenoid tissues of children with adenoid hypertrophy and chronic adenoiditis.  

UK PubMed Central (United Kingdom)

OBJECTIVES: The aim of study was to determine the presence of some of the herpesviruses including herpes simplex virus (HSV), Epstein-Barr virus (EBV), and cytomegalovirus (CMV) in adenoid tissues of children with adenoid hypertrophy (AH) and chronic adenoiditis (CA) and to investigate the potential role of the herpesviruses in patogenesis of AH and CA. PATIENTS AND METHODS: A total of 72 patients (41 boys, 31 girls; mean age 4 years and 2 months; range 2 to 9 years) who underwent adenoidectomy or adenotonsillectomy (with or without placement of a ventilation tube) in our clinic between October 2007 and May 2008, were included. The patients were divided into two groups, as AH group (n=42) and the CA group (n=30). Adenoid tissues collected from patients in both groups were analyzed by polymerase chain reaction (PCR) for the presence of HSV, EBV and CMV-DNA. RESULTS: The results of the PCR indicated that 33.3% in the AH group and 36.6% in the CA group were herpesvirus DNA positive. Among the herpesviruses studied, HSV-DNA was detected at the highest level (14.2% and 16.6%, respectively) in both groups, although the difference between the groups was not significant. EBV-DNA positiveness was 11.9% and CMV-DNA was 4.7% in the AH group, whereas, EBV-DNA positiveness was 13.3% and CMV-DNA was 6.6% in the CA group. CONCLUSION: Herpesviruses were determined at a high rate in adenoid tissue of children with AH and CA, suggesting that there may be a potential relationship between the presence of herpesviruses and occurrence of AH and CA in children. However, more extensive studies are required to elucidate the role of herpesviruses in the pathogenesis of AH or CA.

Karl?da? T; Bulut Y; Kele? E; Alpay HC; Seyrek A; Orhan ?; Karl?da? GE; Kaygusuz ?

2012-01-01

9

ADENOIDS IN ADULT SIBLINGS : IS IT FAMILIAL ?  

Directory of Open Access Journals (Sweden)

Full Text Available Waldeyer’s ring is a collection of lymphoid tissue at the entrance to the aerodigestive tract.Adenoids are present in the nasopharyx.They begin to regress from the age of 8 to 10 years and nearly always disappear by adulthood.The persistent presence of adenoid tissue after puberty has been reported in literature.While investigating a case of nasal obstruction in adults,the possibility of persistence of adenoid tissue should be borne in mind.

Sulabha M Naik; Mahendra S Naik; Ginni Datta; Chandraprakash Sharma; Dalbir Singh

2012-01-01

10

Assessment of Adenoid Size in Children  

Directory of Open Access Journals (Sweden)

Full Text Available Adenoid hypertrophy is one of the most common diseases in the pediatric population, and can cause nasal obstruction, snoring, mouth breathing, and alteration in facial development in children. Flexible fiberoptic nasolaryngoscopey was the gold standard method for evaluation of adenoid and nasopharyngeal obstruction. The aim of this study was evaluation results and agreement of flexible flexible fiberoptic nasolaryngoscopey, Adenoid lateral x-ray and intraoperative observation diagnosis of adenoid hypertrophy and its intensity. In a cross-sectional and descriptive-analytical study, 50 pediatric patients who had suffered from nasal obstruction and mouth breathing were selected in this study to undergo adenoidectomy. The size of adenoid measured by flexible fiberoptic nasolaryngoscopey, lateral neck radiography and intraoperative observation of adenoid size. Results of three studied methods in diagnosis of adenoid hypertrophy and its severity were compared. Twenty two of patients were boy and 28 of them were girl. Mean age of patients was 6.26 ± 1.81 year in the range of 3-12 year. The agreement rate of Lateral Neck Radiography in determination of adenoid hypertrophy with intraoperative observation of adenoid size and flexible fiberoptic nasolaryngoscopey was 70 and 50%, respectively and between flexible fiberoptic nasolaryngoscopey and intraoperative observation of adenoid size was 72% and between three methods was 48%. The agreement rate of each three methods in diagnosis of adenoid hypertrophy was 100%. Significantly strong correlation was found between intraoperative observation of adenoid size with lateral neck radiography and flexible fiberoptic nasolaryngoscopey and poor correlation was found between Lateral Neck Radiography and flexible fiberoptic nasolaryngoscopey.

Shahin Abdollahi-Fakhim; Masood Naderpoor; Nikzad Shahid; Reza Javadrashid; Omid Mashrabi; Majid Ravaghi

2008-01-01

11

Adenoids in adult siblings : Is it familial ?  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Waldeyer’s ring is a collection of lymphoid tissue at the entrance to the aerodigestive tract.Adenoids are present in the nasopharyx.They begin to regress from the age of 8 to 10 years1 and nearly always disappear by adulthood.The persistent presence of adenoid tissue after puberty has been reported...

Naik, Sulabha M; Department of E.N.T.,M M Institute of Medical Sciences & Research, Mullana; Naik, Mahendra S; Department of E.N.T.,M M Institute of Medical Sciences & Research, Mullana

12

Bacteriology of symptomatic adenoids in children.  

UK PubMed Central (United Kingdom)

BACKGROUND: Children with adenoid hypertrophy have been shown to harbor pathogenic bacteria in the nasopharynx despite antibiotics. Removal of the adenoid is associated with a reduction in the bacterial count. AIMS: The study was done to determine the bacteriology of the adenoid tissue in chronic adenotonsillitis and adenoid hypertrophy, and determine the antibiotic sensitivity of potential pathogens. MATERIALS AND METHODS: This is a descriptive study conducted on 100 patients aged between three and twelve years who underwent adenotonsillectomy/adenoidectomy. After adenoidectomy, the specimen along with the swab taken from the surface of the adenoid was sent for microbiological examination. After 48 and 96 hours, the microbial growth was identified and the antibiotic-sensitivity pattern of the isolate was studied. RESULTS: Aerobic organisms grew in 93% of the specimens and anaerobic organisms in 68%, whereas 7% had no growth. The surface was predominated by commensals and the pathogens were mainly found in the core. The predominant pathogens were Staphylococcus aureus, Streptococcus pneumoniae, and Enterococcus species. The organisms were resistant to penicillin but showed sensitivity to co-amoxiclav and ciprofloxacin. Co-amoxiclav and ciprofloxacin should be considered as the first line of medical treatment for adenotonsillar diseases. CONCLUSIONS: Infection is the main cause of adenoid hypertrophy. Amoxicillin with potassium clavulanate and ciprofloxacin should be considered as the drugs of choice for all adenotonsillar diseases. Early and prompt treatment of adenoid hypertrophy with appropriate antibiotics will avoid unnecessary exposure to repeated antimicrobial therapy, thereby maintaining the beneficial effects of the normal adenoid flora.

Rajeshwary A; Rai S; Somayaji G; Pai V

2013-02-01

13

Pulmonary adenoid cystic carcinoma : An unusual presentation  

Directory of Open Access Journals (Sweden)

Full Text Available Adenoid cystic carcinoma is a rare but distinctive salivary gland type malignant neoplasm that arises infrequently in the respiratory tract, where it is largely seen in the trachea or large airways. A 29-year-old female who presented with a peripheral lung mass due to pulmonary adenoid cystic carcinoma is reported in view of its unusual location, early age of presentation and lack of such reports in the recent literature. Lung India 2007; 24 : 28-29

Dixit Ramakant; Nuval Paras

2007-01-01

14

Carcinome ?pidermo?de du sein: ? propos de 3cas et revue de la litt?rature  

Science.gov (United States)

Les carcinomes épidermoides du sein sont rares. Ils sont d'origine métaplasiques. Leur histogénèse est controversée. La présentation clinique et mammographique n'est pas spécifique, l'aspect kystisé des lésions et la présence de nécrose sont recherchés à l’échographie mammaire. Le diagnostic est histologique. Ce cancer est réputé être peu lymphophile et non hormonodépendant. Le traitement rejoint celui des carcinomes infiltrants canalaires et repose sur la chirurgie, la radiothérapie et la chimiothérapie. Le pronostic est péjoratif. Nous rapportons trois cas de carcinome épidermoide du sein colligés au service de Gynécologie obstétrique II au CHU Hassan II de Fès et une revue de la littérature.

Alaoui, Fatima Zohra Fdili; Benkirane, Saad; Chaara, Hekmat; Bouguern, Hakima; Melhouf, Moulay Abdilah

2012-01-01

15

Carcinome épidermoïde du sein: à propos de 3cas et revue de la littérature  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Les carcinomes épidermoides du sein sont rares. Ils sont d'origine métaplasiques. Leur histogénèse est controversée. La présentation clinique et mammographique n'est pas spécifique, l'aspect kystisé des lésions et la présence de nécrose sont recherchés à l’échographie mammaire. Le diagnostic est his...

Alaoui, Fatima Zohra Fdili; Benkirane, Saad; Chaara, Hekmat; Bouguern, Hakima; Melhouf, Moulay Abdilah

16

Adenoid cystic carcinoma of buccal mucosa.  

Science.gov (United States)

Adenoid cystic carcinoma is a malignant neoplasm most commonly originating in the salivary glands of head and neck region. The clinical and pathological findings typical of this tumour include slow growth, perineural invasion and potential local recurrence. Up to 50% of these tumours occur in the intraoral minor salivary glands usually in the hard palate. We present a case report of a 26-year-old woman who was diagnosed with adenoid cystic carcinoma of the right buccal mucosa. The peculiarity of the lesion and the approach we made is the key factor in the presentation. PMID:23761566

Kumar, Anoop N; Harish, M; Alavi, Yasin A; Mallikarjuna, Rachappa

2013-06-11

17

Adenoid cystic carcinoma of the parotid gland  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Adenoid cystic carcinoma (ACC) of salivary glands is a slow-growing malignant tumor, characterized by wide local infiltration, perineural spread, a propensity to local recurrence and late distant metastasis. Although ACC is the second most common malignant salivary gland neoplasm and constitutes app...

Godge, Pournima; Sharma, Shubhra; Yadav, Monica

18

Adenoid cystic carcinoma of base of tongue.  

Science.gov (United States)

Adenoid cystic carcinoma (ACC) is a rare malignant tumour arising from salivary glands. ACC of the head and neck shows a long natural course, high recurrence rates, late metastasis and a tendency for perineural invasion. The authors present a woman with ACC at base of tongue with good response to radiotherapy. PMID:22744242

Akhavan, Ali; Navabii, Hossein; Saeb, Mohsen

2012-06-28

19

M?tastase c?r?brale d'un carcinome du col ut?rin  

Science.gov (United States)

Les métastases cérébrales des cancers du col de l?utérus sont extrêmement rares. Elles sont généralement supra-tentorielles, survenant à un stade avancé de la maladie et dans un cadre de néoplasie polymétastatique. La tumeur primitive est le plus souvent un carcinome épidermoïde peu différencié. Leur pronostic reste sombre malgré toutes les options thérapeutiques. Vu la rareté de cet événement et le peu de cas publiés dans la littérature, nous rapportons l'observation clinique d'une jeune patiente de 44 ans, opérée pour un carcinome du col utérin et qui présente 14 mois plus tard des métastases cérébrales sus et sous tentorielles associées à des métastases ganglionnaires lombo-aortique, médiastinale et sus-claviculaire. Elle a bénéficié d'un traitement palliatif associant une chimiothérapie et une radiothérapie pan encéphalique. Devant l'altération rapide de l'état général, la patiente a été mise sous un traitement symptomatique et des soins de support.

Chekrine, Tarik; Hassouni, Abdesalam; Jouhadi, Hassan; Sahraoui, Souha; Bouchbika, Zineb; Taleb, Amina; Benchakroun, Nadia; Tawfiq, Nezha; Benider, Abdellatif

2013-01-01

20

Regrowth of the adenoids after coblation adenoidectomy: Cephalometric analysis.  

UK PubMed Central (United Kingdom)

OBJECTIVES/HYPOTHESIS: To analyze the prevalence of adenoid regrowth at 1 year after coblation adenoidectomy using cephalometric radiography. STUDY DESIGN: Retrospective analysis. METHODS: One hundred eighty-eight children who underwent adenoidectomy from June 2006 through September 2010 were included. Demographic data, preoperative size of palatine tonsils, presence of allergic rhinitis, concurrent operation of recurrent middle ear effusion, and preoperative and postoperative Korean version of Obstructive Sleep Apnea-18 (KOSA-18) scores were analyzed. The size of the adenoids was measured three times in all the children by lateral cephalometry; preoperatively, at 1 month after adenoidectomy to observe adenoid residual; and at 1 year after surgery to observe adenoid regrowth. RESULTS: The adenoid regrowth at 1 year after adenoidectomy was observed in 25 children (13.3%), and the adenoid residual at 1 month after surgery was observed in 11 children (5.9%) in the cephalometry. Seven of the 11 children with residual disease (63.6%) had adenoid regrowth at 1 year. The regrowth group was significantly younger than no regrowth group, and the preoperative adenoids were larger in regrowth group than in no regrowth group. The symptoms of sleep disordered breathing recurred in two patients and they had revision adenoidectomy. CONCLUSION: The regrowth rate of the adenoids at 1 year was not low. However, most of the patients were asymptomatic. The adenoid residual at 1 month contributed to regrowth at 1 year, and the risk factors of the adenoid regrowth were younger age and larger initial size of the adenoids. LEVEL OF EVIDENCE: 2b. Laryngoscope, 2013.

Kim SY; Lee WH; Rhee CS; Lee CH; Kim JW

2013-08-01

 
 
 
 
21

Primary adenoid cystic carcinoma of the orbital apex.  

UK PubMed Central (United Kingdom)

Adenoid cystic carcinoma is an uncommon malignant tumor of epithelial origin typically arising from salivary glands. Orbital involvement may occur via direct or perineural spread from a lacrimal gland or sinonasal source. Primary orbital adenoid cystic carcinoma without involvement of the lacrimal gland is rare. The authors report a 53-year-old woman who was examined for insidious monocular vision loss and was found to have a primary adenoid cystic carcinoma of the orbital apex and cavernous sinus. Systemic workup for a primary source, including ipsilateral lacrimal gland biopsy, was negative. One must maintain a high index of suspicion for adenoid cystic carcinoma when evaluating orbital tumors.

Walsh RD; Vagefi MR; McClelland CM; Alonso-Basanta M; Newman JG; Farkas T; Tamhankar MA

2013-01-01

22

Adenoid cystic carcinoma of the breast  

International Nuclear Information System (INIS)

Adenoid cystic carcinoma of the breast is a rare neoplasm, accounting for only 0.1% of all malignant breast tumours. It is more common in women in the sixth decade of their lives and often in the sub areolar area. The clinical criteria is not specific and the radiographic examination showed a benign-appearing tumour. The preoperative diagnosis is possible with fine-needle aspiration cytology. The diagnosis is made by histological examination, presented a difficult differential diagnosis with cribriform carcinoma; so it is necessary to use histochemical or immunohistochemical techniques. The treatment is not well established. It consists of lumpectomy with radiation or mastectomy. Compared to other locations, adenoid cystic carcinoma of the breast has a favorable prognosis. Lymph node involvement or distant metastases seldom occur. The aim of our study is to describe the epidemiological, clinico pathological characteristics, the treatment and the prognosis of this rare type of breast tumour. (authors)

2009-01-01

23

Adenoid cystic carcinoma of the parotid gland  

Science.gov (United States)

Adenoid cystic carcinoma (ACC) of salivary glands is a slow-growing malignant tumor, characterized by wide local infiltration, perineural spread, a propensity to local recurrence and late distant metastasis. Although ACC is the second most common malignant salivary gland neoplasm and constitutes approximately one-third of all salivary gland malignancies, it is relatively rare in parotid gland. Here, we present a case report of a cribriform type of ACC involving parotid salivary gland in a 66-year-old female.

Godge, Pournima; Sharma, Shubhra; Yadav, Monica

2012-01-01

24

[Primary adenoid cystic carcinoma in breast].  

Science.gov (United States)

Adenoid cystic carcinoma (ACC) of the breast is a rare neoplasm. We report two observations occurring in female patients, 54 and 65 years old, who consulted for a mastodynia. Clinical examination showed limited painful breast nodules. On ultrasound and mammography they are well-limited bulky mass without microcalcifications. Diagnosis was based on final histopathological exam completed by immunohistochemistry or after slides review. The two patients were treated by mammectomy plus adjuvant radiotherapy and remain alive in remission with a follow-up of 29 and 36 months. PMID:19097926

Sbitti, Y; Kadiri, H; Fetohi, M; Elghissassi, I; M'rabti, H; Boutayeb, S; Ichou, M; Boussen, H; Errihani, H

2008-12-18

25

[Primary adenoid cystic carcinoma in breast].  

UK PubMed Central (United Kingdom)

Adenoid cystic carcinoma (ACC) of the breast is a rare neoplasm. We report two observations occurring in female patients, 54 and 65 years old, who consulted for a mastodynia. Clinical examination showed limited painful breast nodules. On ultrasound and mammography they are well-limited bulky mass without microcalcifications. Diagnosis was based on final histopathological exam completed by immunohistochemistry or after slides review. The two patients were treated by mammectomy plus adjuvant radiotherapy and remain alive in remission with a follow-up of 29 and 36 months.

Sbitti Y; Kadiri H; Fetohi M; Elghissassi I; M'rabti H; Boutayeb S; Ichou M; Boussen H; Errihani H

2009-01-01

26

Cystic adenoid carcinoma of sphenoidal sinus  

Directory of Open Access Journals (Sweden)

Full Text Available Adenoid cystic carcinoma (ACC) is a malignant epithelial tumor of the salivary glands, which usually gives metastases late, but his persistent and aggressive because of its ability to infiltrate surrounding tissue and nerve fibers. ACC of paranasals sinus may spread following the path of the cranial nerves. The close relationship with vital structures prevents complete tumor resection leaving positive margins up to 80 % of patients, mainly at the base of the skull with a high rate of local recurrences and late metastases, aggressive due to its ability to infiltrate surrounding tissue and nerve fibers.

Fuente-Cañibano R; Muñoz-Herrera AM

2012-01-01

27

[Carcinoma adenoids cysticum--dispensary case  

UK PubMed Central (United Kingdom)

In the article the dispensary case of carcinoma adenoids cysticum, highly rare disease of the mandibula is discussed. Clinical and an X-ray examinations revealed many similarities of this disease with cystic radicularis. The correct diagnosis could not be set until histopathological findings of the tissue taken at marsupialization were known. 69 years old female patient was further radically treated in the clinical hospital, where the removed mandibula was replaced by the reconstruction plate. In the literature this disease is presented merely as a metastasis. In the conclusion the accurate and complex examination as well as the necessity of the pathohistological examination of each tissue taken at the oral surgery is stressed.

Camplin T

1990-01-01

28

[Neutron therapy for adenoid cystic carcinoma].  

Science.gov (United States)

In the treatment of adenoid cystic carcinomas, certain situations such as inoperable tumors, macroscopic tumor residues following surgery and recurrences occurring with the previous therapeutic strategies (surgery and/or photon radiotherapy) are afflicted with frequent local recurrences. In these situations the use of radiotherapy with fast neutrons (densely ionizing radiation with high energy transfer) results in absence of recurrences in approx. 70% of the cases, according to data in the literature. The advantage of using neutrons lies in their greater biological effect on slowly growing tumors. In the Hospital for Radiotherapy of the Münster University neutron therapy has been applied since 1986 for these indications using a DT neutron generator (14 MeV). Based on the results obtained in the treatment of 8 patients and a review of the literature, indications for, treatment planning and implementing of neutron therapy is illustrated. Particular consideration is given to CT and MRT. Neutron therapy offers an alternative to previously existing treatment methods for locally advanced adenoid cystic carcinomas or highly differentiated malignomas of the salivary glands. Its effectiveness should be verified by studies involving larger numbers of patients and longer observation periods. PMID:1966334

Pötter, R; Naszaly, A; Hemprich, A; Haverkamp, U; al-Dandashi, C; Höver, K H; Loncar, I

29

[Neutron therapy for adenoid cystic carcinoma  

UK PubMed Central (United Kingdom)

In the treatment of adenoid cystic carcinomas, certain situations such as inoperable tumors, macroscopic tumor residues following surgery and recurrences occurring with the previous therapeutic strategies (surgery and/or photon radiotherapy) are afflicted with frequent local recurrences. In these situations the use of radiotherapy with fast neutrons (densely ionizing radiation with high energy transfer) results in absence of recurrences in approx. 70% of the cases, according to data in the literature. The advantage of using neutrons lies in their greater biological effect on slowly growing tumors. In the Hospital for Radiotherapy of the Münster University neutron therapy has been applied since 1986 for these indications using a DT neutron generator (14 MeV). Based on the results obtained in the treatment of 8 patients and a review of the literature, indications for, treatment planning and implementing of neutron therapy is illustrated. Particular consideration is given to CT and MRT. Neutron therapy offers an alternative to previously existing treatment methods for locally advanced adenoid cystic carcinomas or highly differentiated malignomas of the salivary glands. Its effectiveness should be verified by studies involving larger numbers of patients and longer observation periods.

Pötter R; Naszaly A; Hemprich A; Haverkamp U; al-Dandashi C; Höver KH; Loncar I

1990-01-01

30

Clinical review--breast adenoid cystic carcinoma.  

UK PubMed Central (United Kingdom)

OBJECTIVES: To review the published literature on the diagnosis and management of adenoid cystic carcinoma (ACC) of the breast. MATERIALS AND METHODS: Papers were identified by searching PubMed using the terms « adenoid cystic carcinoma » and « breast ». Additional papers were identified by reviewing references of relevant articles. RESULTS: ACC of the breast is a rare tumour comprising less than 0.1% of breast malignancies. Its cellular origin in the breast remains unclear. The histological characteristics of ACC in the breast are similar to those of ACC of the salivary glands. However the prognosis of ACC of the breast is better than that of other localizations with prolonged survival. Breast-conserving treatment including postoperative radiotherapy seems to be equivalent to mastectomy alone with respect to survival. The value of adjuvant systemic therapies is not established. Late relapses can occur, so long-term follow-up is mandatory for these patients. CONCLUSIONS: ACC of the breast has a favourable prognosis. An accurate diagnosis and appropriate treatment are therefore important.

Boujelbene N; Khabir A; Boujelbene N; Jeanneret Sozzi W; Mirimanoff RO; Khanfir K

2012-04-01

31

[Risk factors to develop adenoid vegetations in children  

UK PubMed Central (United Kingdom)

To evaluate perinatal factors of risk to develop adenoid vegetations in childhood, 600 children were examined. Their perinatal period and health in the first year of life were investigated. 400 examinees aged 2-12 years had adenoids of the second-third degree. 200 children aged 13-14 had no history of the lymphadenoid pharyngeal ring. The degree of the studied factors impact on development of pharyngeal tonsil affection was estimated using the unifactor dispersion analysis. Correlation was found between some complications of pregnancy and labour, health problems at birth and first year of life and development of adenoid vegetations.

Borzov EV

2003-01-01

32

[Rare site of an adenoid cystic carcinoma in the nasopharynx  

UK PubMed Central (United Kingdom)

We report the case of a 63-year-old patient suffering from a nasopharyngeal adenoid cystic carcinoma. She presented with increased oral secretion and pharyngeal irritation, Horner's syndrome, and trigeminal neuralgia. Magnetic resonance imaging scans revealed a tumor of the nasopharyngeal space invading the right cranial base. Lymph node metastases were clinically excluded. The histological sample confirmed an adenoid cystic carcinoma, which was therapeutically treated with adequate radiotherapy. Based on the presented case report and a review of the literature, we discuss the diagnosis and treatment of adenoid cystic carcinomas of the nasopharynx.

Karapantzos I; Kehl R; Mpouras N; Markmann HU; Huber I

2002-08-01

33

Adenoid Cystic Carcinoma of External Auditory Canal  

Directory of Open Access Journals (Sweden)

Full Text Available Adenoid cystic carcinoma is extremely rare tumour that accounts for approximately 5% of primary malignancy of external auditory canal. These tumours are related with a high risk of recurrences and significant morbidities from surgical management and adjuvant radiotherapy. Despite the aggressive management for these tumours, many patients succumb to distant metastasis, making overall prognosis of these tumours poor. Although ACC of EAC has been reported in 5th decade, but its occurrence in young patient is very rare. We report a rare case of ACC in a young 22 years old female, who presented with ear canal mass and ear pain. Biopsy suggested mass to be ACC. Patient underwent wide local excision followed by adjuvant radiotherapy.

Sanjeev Bhagat; Saurabh Varshney; Sampan Singh Bist; Sarita Mishra; Vinish Aggarwal

2012-01-01

34

The mutational landscape of adenoid cystic carcinoma.  

Science.gov (United States)

Adenoid cystic carcinomas (ACCs) are among the most enigmatic of human malignancies. These aggressive salivary gland cancers frequently recur and metastasize despite definitive treatment, with no known effective chemotherapy regimen. Here we determined the ACC mutational landscape and report the exome or whole-genome sequences of 60 ACC tumor-normal pairs. These analyses identified a low exonic somatic mutation rate (0.31 non-silent events per megabase) and wide mutational diversity. Notably, we found mutations in genes encoding chromatin-state regulators, such as SMARCA2, CREBBP and KDM6A, suggesting that there is aberrant epigenetic regulation in ACC oncogenesis. Mutations in genes central to the DNA damage response and protein kinase A signaling also implicate these processes. We observed MYB-NFIB translocations and somatic mutations in MYB-associated genes, solidifying the role of these aberrations as critical events in ACC. Lastly, we identified recurrent mutations in the FGF-IGF-PI3K pathway (30% of tumors) that might represent new avenues for therapy. Collectively, our observations establish a molecular foundation for understanding and exploring new treatments for ACC. PMID:23685749

Ho, Allen S; Kannan, Kasthuri; Roy, David M; Morris, Luc G T; Ganly, Ian; Katabi, Nora; Ramaswami, Deepa; Walsh, Logan A; Eng, Stephanie; Huse, Jason T; Zhang, Jianan; Dolgalev, Igor; Huberman, Kety; Heguy, Adriana; Viale, Agnes; Drobnjak, Marija; Leversha, Margaret A; Rice, Christine E; Singh, Bhuvanesh; Iyer, N Gopalakrishna; Leemans, C Rene; Bloemena, Elisabeth; Ferris, Robert L; Seethala, Raja R; Gross, Benjamin E; Liang, Yupu; Sinha, Rileen; Peng, Luke; Raphael, Benjamin J; Turcan, Sevin; Gong, Yongxing; Schultz, Nikolaus; Kim, Seungwon; Chiosea, Simion; Shah, Jatin P; Sander, Chris; Lee, William; Chan, Timothy A

2013-05-19

35

Adenoid cystic carcinoma of the cervix.  

Directory of Open Access Journals (Sweden)

Full Text Available Adenoid cystic carcinoma constitute around 0.4 to 1.7% of all carcinomas of cervix. It generally presents in elderly age group, however few cases in younger age have also been reported. Majority of cases present in early stage. Though concluding statement regarding the results cannot be made from the cases accumulated from the various reported series, nonetheless this review shows that radiotherapy too is effective in early stage and even in stage I results with radiotherapy appear better than surgery. In advanced stage outcome is invariably poor. In early stage main pattern of failure is distant metastasis. Both local and distant failure are observed in stage III and IV. Though lung is the commonest site of metastases (51%), abdominal cavity and brain are also found to be involved in some cases. Limited experience shows effectiveness of high doses of cisplatin and multiagent chemotherapy. Cases of early stage disease having risk for metastases and local failure should be identified and managed with multimodality treatment using surgery for bulky disease with post-operative radiotherapy and chemotherapy. In advanced stages combination of chemotherapy and radiotherapy is required. Exenterative surgery for central failure has been used effectively. Overall no evidence of disease rate is found to be about 48%, with mean follow-up of 39 months.

Dixit S; Singhal S; Vyas R; Murthy A; Baboo H

1993-01-01

36

Adenoid cystic carcinoma of uterine cervix in a young patient  

Directory of Open Access Journals (Sweden)

Full Text Available Adenoid cystic carcinoma of uterine cervix is a rare tumor. Its origin is debatable. It has a high incidence in postmenopausal women but rarely can develop in patients under 40. An association with squamous cell carcinoma has been described. We report a case of adenoid cystic carcinoma of the endocervical canal with foci of squamous cell carcinoma in a 34-year-old suffering from menorrhagia associated with blood-stained vaginal discharge. Per vaginum and per speculum examination revealed a growth. Cervical biopsy showed bits of tissue, suggesting adenoid cystic carcinoma. Patient was operated upon and uterus with cervix sent for histopathological examination. We report this case because of its rarity, particularly in young patients, with description of illustrative pathology and discussion on the histological diagnosis.

Seth Ankit; Agarwal Asha

2009-01-01

37

Asynchronous adenoid cystic carcinoma of the urinary bladder  

International Nuclear Information System (INIS)

Histologic variants of prostatic carcinoma are readily reorganized. In this report, we describe a rare variant, adenoid cystic carcinoma in a 75-year-old man previously diagnosed to have transitional cell carcinoma of the urinary bladder. The diagnosis of adenoid cystic carcinoma was made by the characteristic microscopic features of the tumor morpholologically and immunohistochemically. Two months later he was found to have metastatic disease. The patient's treatment consisted of chemotherapy in combination with prednisone and hormonal therapy. Five and half months after diagnosis, he died with metastatic disease. Making this case unique is the asynchronous occurrence of this variant with transitional cell carcinoma of the urinary bladder, which has never be reported in the literature. We discussed the histopathologic and immunohistochemical features of adenoid cystic carcinoma of the prostate with review of literature. (author)

2006-01-01

38

Primary Adenoid Cystic Carcinoma Presenting as an Orbital Apex Tumor  

Science.gov (United States)

Primary adenoid cystic carcinoma occurring in the orbital apex is rare. We present the clinical features of a patient who initially presented with the clinical and radiologic features of an orbital pseudotumor. He developed features of orbital apex syndrome and repeat imaging showed a tumor of the orbital apex with intracranial invasion. He underwent radical skull base surgery and pathologic examination revealed adenoid cystic carcinoma in the orbital apex with a normal lacrimal apparatus. He received post operative radiation and the outcome in the light of a review of available literature is being discussed.

Venkitaraman, Ramachandran; Madhavan, Jayaprakash; Ramachandran, Krishnankuttynair; Abraham, Elizabeth; Rajan, Balakrishnan

2008-01-01

39

[Adenoid cystic carcinoma of a lacrimal gland with lung metastases  

UK PubMed Central (United Kingdom)

We encountered a patient with adenoid cystic carcinoma of a lacrimal gland and multiple pulmonary metastases. The patient underwent resection of a left orbital tumor, which was followed by 60 Gy of radiation therapy. The pathological diagnosis was adenoid cystic carcinoma with a cribriform pattern. About one year after diagnosis, metastases to the lung, liver, bone, and skin were found, but there was ro local recurrence. A chest CT image revealed findings characteristic of hematogenous metastases: multiple discrete tumor shadows distributed over the entire left and right lung fields. We collected 24 reports of similar cases. The cases with pulmonary metastases had poor outcomes.

Hironaka M; Kobayashi J; Kitamura S

1997-06-01

40

[Adenoid cystic carcinoma of a lacrimal gland with lung metastases].  

Science.gov (United States)

We encountered a patient with adenoid cystic carcinoma of a lacrimal gland and multiple pulmonary metastases. The patient underwent resection of a left orbital tumor, which was followed by 60 Gy of radiation therapy. The pathological diagnosis was adenoid cystic carcinoma with a cribriform pattern. About one year after diagnosis, metastases to the lung, liver, bone, and skin were found, but there was ro local recurrence. A chest CT image revealed findings characteristic of hematogenous metastases: multiple discrete tumor shadows distributed over the entire left and right lung fields. We collected 24 reports of similar cases. The cases with pulmonary metastases had poor outcomes. PMID:9294303

Hironaka, M; Kobayashi, J; Kitamura, S

1997-06-01

 
 
 
 
41

Adenoid cystic carcinoma of the cervix in a young patient.  

Directory of Open Access Journals (Sweden)

Full Text Available Adenoid cystic carcinoma of the cervix is a rare disease. It usually occurs in an elderly age group. A case who presented at a younger age (30 years) is being reported. The chief complaint was excessive vaginal bleeding for 2 months. Per vaginum examination revealed a growth. She was staged FIGO IIIb. She was treated with radical radiotherapy. Disease regressed slowly and complete local response appeared after six months of treatment. Presentation of adenoid cystic carcinoma in younger age group and effect of radiotherapy in advanced stage is reviewed.

Dixit S; Singhal S; Neema J; Soornarayan R; Baboo H

1994-01-01

42

Adenoid basal carcinoma of the cervix in a 20-year-old female: a case report  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background Adenoid basal carcinoma of the cervix is a rare condition mostly occurring among postmenopausal women. Although it can be confused with adenoid cystic carcinoma of the cervix, adenoid basal carcinoma has several clinicopathologic features that will allow distinction from adenoid cystic carcinoma. Case presentation This is the case of a twenty-year old African-American female who initially presented with a high-grade squamous intraepithelial lesion on Pap smear, with a subsequent cervical LEEP specimen revealing adenoid basal carcinoma. The lesion showed the characteristic histologic features of adenoid basal carcinoma and was positive for the immunohistochemical marker EMA and negative for collagen IV, further defining the tumor while helping to rule out the possibility of adenoid cystic carcinoma. As far as the authors are aware, this is the youngest reported case of adenoid basal carcinoma to date. Conclusion This case shows that adenoid basal carcinoma can deviate markedly from its typical postmenopausal demographics to affect women as young as 20 years of age. In addition, adenoid basal carcinoma has several identifiable features that will differentiate it from adenoid cystic carcinoma including histologic and cellular morphologies, as well as immunohistochemistry. Treatment for most patients involves hysterectomy, LEEP, or a conization procedure which provides a favorable prognosis because of this lesion's low potential for recurrence and metastasis.

DePond William; Flauta Victor; Lingamfelter Daniel; Schnee David; Menendez Kristyn

2006-01-01

43

Adenoid ciliostimulation in children with chronic otitis media.  

UK PubMed Central (United Kingdom)

OBJECTIVE: Adenoid hypertrophy and chronic adenoiditis are associated with an increased incidence of chronic otitis media. This study intends to determine the relationship between chronic otitis media and dynamic ciliary beat frequency in children undergoing adenoidectomy. STUDY DESIGN: Prospective, controlled study. SETTING: Pediatric tertiary care hospital. SUBJECTS AND METHODS: Children undergoing adenoidectomy were enrolled. Patients were stratified according to their indication for surgery, including adenotonsillar hypertrophy with obstructive sleep apnea, chronic otitis media with effusion, or recurrent episodes of acute otitis media. Adenoids were harvested using the curette. Tissue was sectioned and allowed to equilibrate in basal media for 24 hours. Cilia-bearing tissue was then stimulated using isoproterenol or methacholine. Ciliary beat frequency was serially reordered and analyzed using the Sisson-Ammons Video Analysis software program. RESULTS: Baseline ciliary beat frequency was similar in all groups (N = 47, total). Using isoproterenol, children with chronic otitis media with effusion demonstrated a blunted dynamic ciliary response at 2 and 3 hours relative to control (P = .0176 and P = .0282). Methacholine-stimulated ciliary beat frequency was not different between each group. CONCLUSION: At 2 and 3 hours following isoproterenol stimulation, there was a significant blunting of dynamic ciliary beat frequency in children with chronic otitis media with effusion. This ciliary dysfunction may provide a physiological explanation related to chronic adenoiditis in children with chronic otitis media.

Andreoli SM; Schlosser RJ; Wang LF; Mulligan RM; Discolo CM; White DR

2013-01-01

44

Adenoidal and tonsillar lymphocyte subsets in AIDS children.  

Science.gov (United States)

Tonsils and adenoids are secondary lymphoid organs exposed to the environment. The most important classifications of AIDS include the lymphocyte subsets of peripheral blood. We have studied the lymphocyte subsets in peripheral blood and secondary lymphoid organs in a control group of children suffering adenotonsillar pathology and in five children with AIDS and the same adenotonsillar pathology. The antigen surface markers were determined by flow cytometry in lymphocytes isolated from peripheral blood, and from tonsils and adenoids after tonsillectomy and adenoidectomy, in the control group and in children diagnosed with AIDS. The most important findings in tonsils and adenoids were a decrease of the total T lymphocytes, helper T lymphocytes and CD4/CD8 ratio; an increase of cytotoxic T lymphocytes and B lymphocytes, as well as a 200% increase in monocytes of AIDS-affected children. These observations show the value of analyzing the lymphocyte subsets of the tonsils and adenoids of AIDS-affected children, and establishing an earlier relation to clinical symptoms. PMID:9865438

Lopez-Gonzalez, M A; Lucas, M; Sanchez, B; Mata, F; Delgado, F

1998-10-15

45

Carcinoma adenoide quístico primario de bronquio lobar: Caso clínico/ Primary adenoid cystic carcinoma of the lobar bronehus: Case report  

Scientific Electronic Library Online (English)

Full Text Available Abstract in spanish El carcinoma adenoide quístico primario de la vía aérea es una neoplasia muy rara. Reportamos el caso de un paciente de 60 años de edad quien consultó por hemoptisis y disnea de esfuerzo. Una tomografía computarizada del tórax reveló una masa en el bronquio fuente y lobar superior del pulmón derecho. Se realizó una lobectomía superior derecha en manguito. El estudio histopatológico mostró un carcinoma adenoide quístico. Se administró radioterapia adyuvante. La cirugía y la radioterapia son las bases del manejo de este tipo de tumores. Abstract in english Primary airway adenoid cystic carcinoma is very uncommon. We report a 60 years old male consulting for hemoptysis and dyspnea. A chest CAT scan showed a mass in the right superior lobar bronehus. The patient was subjected to a right superior sleeve lobectomy and the pathological study of the surgical piece revealed an adenoid cystic carcinoma. The patient received adjuvant radiotherapy. Surgery and radiation therapy are the mainstay of treatment for this type of tumors.

TAPIAS-VARGAS, LEONIDAS; TAPIAS-VARGAS, LUIS FELIPE; TAPIAS, LEONIDAS; GARCÍA, MARÍA EMMA; MANTILLA, JULIO CÉSAR; GARCÍA, ERNESTO

2011-02-01

46

Reprodutibilidade dos métodos radiográficos para avaliação da adenoide Reliability of radiographic parameters in adenoid evaluation  

Directory of Open Access Journals (Sweden)

Full Text Available Embora a avaliação radiográfica da hipertrofia de tonsila faríngea tenha sido constantemente debatida, há ainda carência de estudos que testem a confiabilidade da maioria dos parâmetros radiográficos existentes. OBJETIVO: Verificar a reprodutibilidade intra e interexaminadores de vários métodos destinados à avaliação da tonsila faríngea. Forma de estudo: Estudo de série, metodológico e transversal. MATERIAL E MÉTODO: Quarenta crianças de ambos os sexos, de 4 a 14 anos, foram selecionadas mediante apresentação de queixas de obstrução nasal ou respiração oral, com suspeita de diagnóstico de hipertrofia de tonsila faríngea. Radiografias do cavum faríngeo e telerradiografias ortodônticas foram obtidas e, posteriormente, avaliadas por dois examinadores por meio de instrumentos de avaliação quantitativos e categóricos. RESULTADOS: Todos os parâmetros quantitativos de ambas as modalidades radiográficas apresentaram excelente reprodutibilidade intra e interexaminadores. Dentre os parâmetros categóricos de avaliação da radiografia de cavum, observou-se desempenho relativamente melhor de C-Kurien, C-Wang, C-Fujioka e C-Elwany sobre C-Cohen e C-Ysunza. Em relação aos sistemas destinados à classificação da telerradiografia, C-McNamara apresentou maior reprodutibilidade que C-Holmberg. CONCLUSÃO: A maioria dos instrumentos apresentou reprodutibilidade adequada. No entanto, novas investigações ainda devem ser realizadas com o intuito de determinar a capacidade de cada parâmetro em relação sua acurácia e viabilidade.The assessment of adenoids by x-ray imaging has been the topic of heated debate, but few studies have looked into the reliability of most existing radiographic parameters. OBJECTIVE: This study aims to verify the intra-examiner and inter-examiner reproducibility of the adenoid radiographic assessment methods. MATERIALS AND METHODS: This is a cross-sectional case series study. Forty children of both genders aged between 4 and 14 were enrolled. They were selected based on complaints of nasal obstruction or mouth breathing and suspicion of pharyngeal tonsil hypertrophy. Cavum x-rays and orthodontic teleradiographs were assessed by two examiners in quantitative and categorical terms. RESULTS: All quantitative parameters in both x-ray modes showed excellent intra and inter-examiner reproducibility. Relatively better performance was observed in categorical parameters used in cavum x-ray assessment by C-Kurien, C-Wang, C-Fujioka, and C-Elwany over C-Cohen and C-Ysunza. As for orthodontic teleradiograph grading systems, C-McNamara has been proven to be more reliable than C-Holmberg. CONCLUSION: Most instruments showed adequate reproducibility levels. However, more research is needed to properly determine the accuracy and viability of each method.

Murilo Fernando Neuppmann Feres; Helder Inocêncio Paulo de Sousa; Sheila Márcia Francisco; Shirley Shizue Nagata Pignatari

2012-01-01

47

Reprodutibilidade dos métodos radiográficos para avaliação da adenoide/ Reliability of radiographic parameters in adenoid evaluation  

Scientific Electronic Library Online (English)

Full Text Available Abstract in portuguese Embora a avaliação radiográfica da hipertrofia de tonsila faríngea tenha sido constantemente debatida, há ainda carência de estudos que testem a confiabilidade da maioria dos parâmetros radiográficos existentes. OBJETIVO: Verificar a reprodutibilidade intra e interexaminadores de vários métodos destinados à avaliação da tonsila faríngea. Forma de estudo: Estudo de série, metodológico e transversal. MATERIAL E MÉTODO: Quarenta crianças de ambos os sexos, (more) de 4 a 14 anos, foram selecionadas mediante apresentação de queixas de obstrução nasal ou respiração oral, com suspeita de diagnóstico de hipertrofia de tonsila faríngea. Radiografias do cavum faríngeo e telerradiografias ortodônticas foram obtidas e, posteriormente, avaliadas por dois examinadores por meio de instrumentos de avaliação quantitativos e categóricos. RESULTADOS: Todos os parâmetros quantitativos de ambas as modalidades radiográficas apresentaram excelente reprodutibilidade intra e interexaminadores. Dentre os parâmetros categóricos de avaliação da radiografia de cavum, observou-se desempenho relativamente melhor de C-Kurien, C-Wang, C-Fujioka e C-Elwany sobre C-Cohen e C-Ysunza. Em relação aos sistemas destinados à classificação da telerradiografia, C-McNamara apresentou maior reprodutibilidade que C-Holmberg. CONCLUSÃO: A maioria dos instrumentos apresentou reprodutibilidade adequada. No entanto, novas investigações ainda devem ser realizadas com o intuito de determinar a capacidade de cada parâmetro em relação sua acurácia e viabilidade. Abstract in english The assessment of adenoids by x-ray imaging has been the topic of heated debate, but few studies have looked into the reliability of most existing radiographic parameters. OBJECTIVE: This study aims to verify the intra-examiner and inter-examiner reproducibility of the adenoid radiographic assessment methods. MATERIALS AND METHODS: This is a cross-sectional case series study. Forty children of both genders aged between 4 and 14 were enrolled. They were selected based on c (more) omplaints of nasal obstruction or mouth breathing and suspicion of pharyngeal tonsil hypertrophy. Cavum x-rays and orthodontic teleradiographs were assessed by two examiners in quantitative and categorical terms. RESULTS: All quantitative parameters in both x-ray modes showed excellent intra and inter-examiner reproducibility. Relatively better performance was observed in categorical parameters used in cavum x-ray assessment by C-Kurien, C-Wang, C-Fujioka, and C-Elwany over C-Cohen and C-Ysunza. As for orthodontic teleradiograph grading systems, C-McNamara has been proven to be more reliable than C-Holmberg. CONCLUSION: Most instruments showed adequate reproducibility levels. However, more research is needed to properly determine the accuracy and viability of each method.

Feres, Murilo Fernando Neuppmann; Sousa, Helder Inocêncio Paulo de; Francisco, Sheila Márcia; Pignatari, Shirley Shizue Nagata

2012-08-01

48

Correlación microbiológica en cultivo de adenoides y glue en pacientes con OME Microbiological correlation between adenoid and glue ear cultures in patients with OME  

Directory of Open Access Journals (Sweden)

Full Text Available Introducción: La otitis media con efusión (OME) sigue siendo la patología otológica más prevalente en los preescolares de Chile; su etiología y factores predisponentes aún no están del todo claro; por ende su tratamiento es controversial. Objetivo: Demostrar una correlación microbiológica en cultivos de tejido adenoídeo y glue de ambos oídos en pacientes con OME. Material y método: Estudio prospectivo caso/control, donde se analizaron los cultivos bacterianos de tejido adenoideo y glue de ambos oídos en 40 pacientes con OME y cultivos bacterianos de tejido adenoídeo de 40 pacientes con hiperplasia adenoídea sin OME. Resultados: Casos: Cinco cultivos negativos de adenoides (12,5%), 28 positivos a comensales (70%) y 7 positivos a gérmenes no habituales (17,5%). El glue presentó cultivo negativo en 72,5% OD y 77,5% OI. Los cultivos de adenoides en los controles no difieren mayormente a los casos. Discusión: No se pudo establecer una correlación microbiológica entre glue y adenoides en pacientes con OME. Conclusiones: El número de cultivos de glue negativos se correlaciona con la literatura mundial. No existe un patrón que permita correlacionar los cultivos de adenoides de los casos con los cultivos de glue, ni con los cultivos de adenoides de los controles.Introduction: Otitis Media with Effusion is still the most prevalent otological pathology in preschool children in Chile. Its etiology and predisposing factors are not entirely clear yet. Hence, its treatment is controversial. Aim: To demonstrate a microbiological correlation in adenoid tissue and glue ear cultures in both ears in patients with OME. Material and method: Prospective case control study, which analyzed bacterial adenoid tissue cultures and glue ear cultures in both ears in 40 patients with OME, and a second control group of bacterial cultures in 40 patients with adenoid hyperplasia without ear effusion. Results: Cases: Five negatives in adenoid cultures (12.5%), 28 positive to guest bacteria (70%) and 7 positive at unusual germs (17.5%). The glue ear presented negative culture at 72.5% in the right ear and 77.5% in the left ear. Adenoid control cultures did not differ with OME studied cases. Discussion: A microbiological glue ear and adenoid correlation could not be established. Conclusions: The number of negative glue ear cultures is similar to published literature. There is not a pattern which allows a positive correlation between adenoid cases cultures and glue ear cultures or with control adenoid cultures.

Rodrigo Pinto C; Eduardo Carmine A; Maritza Rahal E

2012-01-01

49

Correlación microbiológica en cultivo de adenoides y glue en pacientes con OME/ Microbiological correlation between adenoid and glue ear cultures in patients with OME  

Scientific Electronic Library Online (English)

Full Text Available Abstract in spanish Introducción: La otitis media con efusión (OME) sigue siendo la patología otológica más prevalente en los preescolares de Chile; su etiología y factores predisponentes aún no están del todo claro; por ende su tratamiento es controversial. Objetivo: Demostrar una correlación microbiológica en cultivos de tejido adenoídeo y glue de ambos oídos en pacientes con OME. Material y método: Estudio prospectivo caso/control, donde se analizaron los cultivos bacterianos (more) de tejido adenoideo y glue de ambos oídos en 40 pacientes con OME y cultivos bacterianos de tejido adenoídeo de 40 pacientes con hiperplasia adenoídea sin OME. Resultados: Casos: Cinco cultivos negativos de adenoides (12,5%), 28 positivos a comensales (70%) y 7 positivos a gérmenes no habituales (17,5%). El glue presentó cultivo negativo en 72,5% OD y 77,5% OI. Los cultivos de adenoides en los controles no difieren mayormente a los casos. Discusión: No se pudo establecer una correlación microbiológica entre glue y adenoides en pacientes con OME. Conclusiones: El número de cultivos de glue negativos se correlaciona con la literatura mundial. No existe un patrón que permita correlacionar los cultivos de adenoides de los casos con los cultivos de glue, ni con los cultivos de adenoides de los controles. Abstract in english Introduction: Otitis Media with Effusion is still the most prevalent otological pathology in preschool children in Chile. Its etiology and predisposing factors are not entirely clear yet. Hence, its treatment is controversial. Aim: To demonstrate a microbiological correlation in adenoid tissue and glue ear cultures in both ears in patients with OME. Material and method: Prospective case control study, which analyzed bacterial adenoid tissue cultures and glue ear cultures (more) in both ears in 40 patients with OME, and a second control group of bacterial cultures in 40 patients with adenoid hyperplasia without ear effusion. Results: Cases: Five negatives in adenoid cultures (12.5%), 28 positive to guest bacteria (70%) and 7 positive at unusual germs (17.5%). The glue ear presented negative culture at 72.5% in the right ear and 77.5% in the left ear. Adenoid control cultures did not differ with OME studied cases. Discussion: A microbiological glue ear and adenoid correlation could not be established. Conclusions: The number of negative glue ear cultures is similar to published literature. There is not a pattern which allows a positive correlation between adenoid cases cultures and glue ear cultures or with control adenoid cultures.

Pinto C, Rodrigo; Carmine A, Eduardo; Rahal E, Maritza

2012-08-01

50

Sialoblastoma in adults: distinction from adenoid cystic carcinoma.  

UK PubMed Central (United Kingdom)

Essentially, sialoblastoma is a disease of infancy with the oldest case presenting at 4 years of age. About one third of pediatric sialoblastoma cases will have a cribriform growth pattern. No adult cases have been reported with a specific diagnosis of sialoblastoma. If even focal cribriforming were present, such cases have undoubtedly been diagnosed as adenoid cystic carcinoma. Such was the circumstance in the 3 adult tumors presented in this report. Each case, however, has the primitive histopathology with discrete nests of basaloid tumor cells, associated bilayered ductal structures and the fibromyxoid stroma characteristic for sialoblastoma with its resemblance to fetal salivary gland or salivary gland with arrested development. One key example has 28-year follow-up. Sialoblastoma, whether in a child or adult with or without a cribriform growth pattern, appears to have a more favorable prognosis than adenoid cystic carcinoma. Aspects of the histological differential diagnosis of these 2 tumors are discussed.

Dardick I; Daley TD; McComb RJ

2010-01-01

51

Adenoid cystic carcinoma on the dorsum of the tongue.  

UK PubMed Central (United Kingdom)

Adenoid cystic carcinoma is a relatively rare epithelial tumor of the salivary glands accounting for about 5-10% of all salivary gland neoplasms. Approximately, 31% of salivary gland neoplasms affect minor salivary glands particularly the palate. It involves tongue in only 19.8% of cases and even rarely the dorsum of the tongue. We report such a rare case that affected dorsum of the tongue in a 45-year-old-female patient.

Sengupta S; Roychowdhury A; Bhattacharya P; Bandyopadhyay A

2013-01-01

52

Adenoid cystic ovarian carcinoma compared with other adenoid cystic carcinomas of the female genital tract.  

UK PubMed Central (United Kingdom)

Adenoid cystic carcinoma (ACC) of the ovary is an extremely rare neoplasm referred to infrequently in the literature. A new case of a pure, primary, ovarian ACC is reported. The patient was a 45-year-old white woman who had a stage IA, well-circumscribed, unilateral, ovarian mass. Histologically, the tumor was composed of small, uniform, and basaloid cells exhibiting predominantly a tubular pattern, as well as demonstrating cribriform and focal solid areas. There was no necrosis and minimal nuclear pleomorphism; the mitotic rate was fewer than three cells per 10 high-power fields. Immunohistochemical examination showed that the tumor cells were strongly positive for cytokeratins CAM 5.2 and AE1/3 and carcinoembryonic antigen. The cells at the periphery of the epithelial aggregates in the cribriform and tubular areas were positive for muscle-specific actin and, occasionally, for S100 protein. Electron microscopic examination revealed that these cells had convoluted nuclei and filamentous structures associated with dense bodies. These findings support a myoepithelial component. A characteristic feature was the production of periodic acid-Schiff stain-positive basement membrane material, which appeared as reduplicated basal lamina by electron microscopic examination. The patient is currently alive, without evidence of recurrence or persistent tumor 7 years after surgical excision. The tumor demonstrated immunohistochemical and ultrastructural findings similar to those of ACCs of salivary gland origin and to other ACCs of the female genital tract. The histogenesis of most ovarian ACCs is through metaplasia of the celomic epithelium, but pure cases might also be of teratomatous origin.

Feczko JD; Jentz DL; Roth LM

1996-04-01

53

Cerebral gliosarcoma, pulmonary adenoid-cystic carcinoma, and pulmonary metastatic gliosarcoma: report of an untreated case.  

UK PubMed Central (United Kingdom)

An elderly woman had a cerebral gliosarcoma with a single pulmonary metastasis, together with a separate pulmonary adenoid-cystic carcinoma. Spontaneous extraneural metastases of primary intracranial neoplasms are exceedingly unusual; so far, only 8 proven cases are recorded in the English language medical literature. The association of cerebral gliosarcoma and a pulmonary adenoid-cystic carcinoma is presumably coincidental.

Ojeda VJ; Sterrett GF

1984-04-01

54

[MicroRNA-profiling in breast- and salivary gland-derived adenoid cystic carcinomas].  

UK PubMed Central (United Kingdom)

INTRODUCTION: Adenoid cystic carcinoma is a salivary gland-derived malignant tumor, but rarely it can originate from the breast, too. The salivary gland-derived form shows a very aggressive clinical outcome, while adenoid cystic carcinoma of the breast has mostly a very good prognosis. Aim: The aim of the authors was to compare the miRNA-expression profile of breast- and salivary gland-derived cases. METHOD: The miRNA-profiles of two salivary gland derived and two breast-derived adenoid cystic carcinoma tissues as well as one normal breast and one salivary gland tissues were analysed using the Affymetrix® Gene Chip. RESULTS: The expression of some miRNAs differed in the tumor tissues compared to their controls: the let-7b was overexpressed in salivary gland-derived adenoid cystic carcinoma, while decreased in breast-derived adenoid cystic carcinoma. In addition, the miR-24 was decreased in salivary gland-derived but overexpressed in breast-derived adenoid cystic carcinomas. The miR-181a-2* was only detected in salivary gland-derived adenoid cystic carcinomas. CONCLUSIONS: Through post-transcriptional regulation of the genes, the diverse expression of some miRNAs may partially explain the diverse clinical outcome of salivary gland-derived and breast-derived adenoid cystic carcinomas.

Kiss O; T?kés AM; Spisák S; Szilágyi A; Lippai N; Szász AM; Kulka J

2013-06-01

55

[Immunomodulators for topical application to prevent and manage chronic adenoiditis in children].  

UK PubMed Central (United Kingdom)

The authors report the results of a study on the efficacy of topical application of the immunomodulator IRS 19 in children presenting with chronic adenoiditis and grade I-III hypertrophy of adenoid vegetation. The use of this preparation is shown to faster and more efficaciously normalize the volume of the lymphoid tissue than irrigation of the nasopharynx with saline solutions. Moreover, the treatment of chronic adenoiditis with IRS 19 promoted normalization of biocenosis of the nasopharyngeal secretion and significantly decreased the abundance of pathogenic microflora. Specifically, the overall frequency of exacerbations and the frequency of exacerbations of adenoiditis decreased three- and two-fold respectively while the duration of the disease shortened. It is recommended that the topical immunomodulator IRS 19 should be included in the programs of planned seasonal treatment of children suffering chronic adenoiditis (to be applied at least 2-3 times annually).

Garashchenko TI; Zelenkova IV; Alferova MV

2011-01-01

56

[Immunomodulators for topical application to prevent and manage chronic adenoiditis in children].  

Science.gov (United States)

The authors report the results of a study on the efficacy of topical application of the immunomodulator IRS 19 in children presenting with chronic adenoiditis and grade I-III hypertrophy of adenoid vegetation. The use of this preparation is shown to faster and more efficaciously normalize the volume of the lymphoid tissue than irrigation of the nasopharynx with saline solutions. Moreover, the treatment of chronic adenoiditis with IRS 19 promoted normalization of biocenosis of the nasopharyngeal secretion and significantly decreased the abundance of pathogenic microflora. Specifically, the overall frequency of exacerbations and the frequency of exacerbations of adenoiditis decreased three- and two-fold respectively while the duration of the disease shortened. It is recommended that the topical immunomodulator IRS 19 should be included in the programs of planned seasonal treatment of children suffering chronic adenoiditis (to be applied at least 2-3 times annually). PMID:21512491

Garashchenko, T I; Zelenkova, I V; Alferova, M V

2011-01-01

57

Advanced adenoid cystic carcinoma of the cervix: a case report and review of the literature.  

UK PubMed Central (United Kingdom)

INTRODUCTION: Adenoid cystic carcinoma is a malignant epithelial neoplasm derived from the salivary glands. Primary adenoid cystic carcinoma of the cervix is extremely rare, accounting for less than 1% of all cervical carcinomas. In this paper we report a case of primary adenoid cystic carcinoma and a review of the related literature. CASE PRESENTATION: A 68 year-old woman was admitted with signs and symptoms suggestive of a cervical cancer. The radiological and pathological investigations confirmed the diagnostic of primary adenoid cystic carcinoma of the cervix at Stage IIIB according to the International Federation of Gynaecology and Obstetrics classification. The patient was managed successfully by concurrent chemo-radiotherapy. CONCLUSION: The optimal management of adenoid cystic carcinoma cannot be established for certain. From our case and from the literature, it appears that combined treatment (surgery, radiotherapy, and chemotherapy) is necessary for achieving a long-term remission. Concurrent chemo-radiotherapy appears to be a logical option for locally advanced disease.

Elhassani LK; Mrabti H; Ismaili N; Bensouda Y; Masbah O; Bekkouch I; Hassouni K; Kettani F; Errihani H

2009-01-01

58

Clinicopathological study of distant metastases of salivary adenoid cystic carcinoma.  

UK PubMed Central (United Kingdom)

Most studies of the clinicopathological characteristics and prognosis of patients with distant metastasis of salivary adenoid cystic carcinoma (SACC) have used small patient samples. To further explore this issue, a descriptive and prognostic study of 467 patients with SACC who were treated from 1963 to 2009 was conducted at a single institution. One hundred and forty-five patients (31.0%) had distant metastases. At least 20% of patients who presented with the early-stage disease and no recurrence developed distant metastasis. The overall 5-, 10-, and 20-year survival rates were 85.6%, 67.4%, and 50.4%, respectively, for patients without distant metastasis, and 69.1%, 45.7%, and 14.3%, respectively, for patients with distant metastasis. The median survival time after distant metastasis was 36 months (range 1-112 months). The prognosis was similar between patients who received treatment for metastasis and those who did not. Patients who were diagnosed with early-stage disease and without local recurrence of the primary tumours could also develop distant metastases. The biological characteristics of adenoid cystic carcinoma were different from those of squamous cell carcinoma. At present, the effectiveness of treatment for distant metastases is not ideal and further research is needed.

Gao M; Hao Y; Huang MX; Ma DQ; Luo HY; Gao Y; Peng X; Yu GY

2013-08-01

59

Clinicopathological study of distant metastases of salivary adenoid cystic carcinoma.  

Science.gov (United States)

Most studies of the clinicopathological characteristics and prognosis of patients with distant metastasis of salivary adenoid cystic carcinoma (SACC) have used small patient samples. To further explore this issue, a descriptive and prognostic study of 467 patients with SACC who were treated from 1963 to 2009 was conducted at a single institution. One hundred and forty-five patients (31.0%) had distant metastases. At least 20% of patients who presented with the early-stage disease and no recurrence developed distant metastasis. The overall 5-, 10-, and 20-year survival rates were 85.6%, 67.4%, and 50.4%, respectively, for patients without distant metastasis, and 69.1%, 45.7%, and 14.3%, respectively, for patients with distant metastasis. The median survival time after distant metastasis was 36 months (range 1-112 months). The prognosis was similar between patients who received treatment for metastasis and those who did not. Patients who were diagnosed with early-stage disease and without local recurrence of the primary tumours could also develop distant metastases. The biological characteristics of adenoid cystic carcinoma were different from those of squamous cell carcinoma. At present, the effectiveness of treatment for distant metastases is not ideal and further research is needed. PMID:23706387

Gao, M; Hao, Y; Huang, M X; Ma, D Q; Luo, H Y; Gao, Y; Peng, X; Yu, G Y

2013-05-23

60

Adenoid Cystic Carcinoma of the Lung with Bilateral Renal Metastases at Presentation in a Young Female  

Directory of Open Access Journals (Sweden)

Full Text Available Adenoid cystic carcinoma of the lung is a relatively rare, slow growing lung neoplasm. Metastases outside the lung are uncommon. Herein, we have reported the case of a patient who presented with a large mass in the right lower lobe of her lung. Bronchial biopsy revealed features suggestive of adenoid cystic carcinoma of thelung with a predominant cribriform architecture. CT abdomen showed features of bilateral renal and liver metastases, but no adrenal metastases.

Kaushik Saha; Debraj Jash; Ankan Bandyopadhyay; Arpita Banerjee

2011-01-01

 
 
 
 
61

Extracts from The Cochrane Library: intranasal corticosteroids for moderate to severe adenoidal hypertrophy.  

UK PubMed Central (United Kingdom)

The "Cochrane Corner" is a quarterly section in the Journal that highlights systematic reviews relevant to otolaryngology-head and neck surgery, with invited commentary to aid clinical decision making. This installment features a Cochrane Review entitled "Intranasal corticosteroids for nasal airway obstruction in children with moderate to severe adenoidal hypertrophy," which finds limited evidence of a short-term improvement in nasal symptoms with a reduction of adenoid size.

Burton MJ; Derkay CS; Rosenfeld RM

2009-04-01

62

Radiological features of adenoid cystic carcinoma of the uterine cervix  

Energy Technology Data Exchange (ETDEWEB)

Adenoid cystic carcinoma (ACC) of the uterine cervix is a rare primary neoplasm of the uterus that occurs in post-menopausal women; its radiological findings have not been described previously. We present the MR findings of a case of ACC. The mass exhibited homogeneous low-signal intensity on T1-weighted images. On T2-weighted images, the mass showed high-signal intensity with a lobulated contour and multiple septum-like internal architectures. It also contained spots of very high-signal intensity, which would represent the mucin in the glandular lumen. The multiple septum-like internal architectures probably represented interglandular fibrous stroma. These MRI findings may be helpful for future diagnoses of ACC of the uterine cervix. (orig.)

Kaku, Ayumi; Kiyosue, Hiro; Matsumoto, Shunro; Mori, Hiromu [Oita University Faculty of Medicine, Department of Academic Radiology, Oita (Japan); Kashima, Kenji [Oita University Faculty of Medicine, Department of Pathology, Oita (Japan); Miyakawa, Isao [Oita University Faculty of Medicine, Department of Gynecology, Oita (Japan)

2005-05-01

63

Primary tuberculosis of nasopharynx (adenoid)- a rare presentation.  

UK PubMed Central (United Kingdom)

Tuberculosis has global presence and no part of human body is immune to it, most frequent site beings lungs. Nasopharyngeal tuberculosis is a rare type of extrapulmonary tuberculosis comprising only less than 1% of tuberculosis found in the upper respiratory tract. The authors are presenting here a case of primary tuberculousis affecting the nasopharynx (adenoids) which is one of the rare differential diagnosis of nasopharyngeal mass. Isolated nasopharyngeal tuberculosis is a rare condition even in the endemic areas. In literature there are varied clinical presentations of nasopharyngeal tuberculosis. Tuberculosis should be one of the differential diagnosis of nasopharyngeal lesion. Biopsy and histologic study should be performed in every patient to avoid misdiagnosis. When treated properly, nasopharyngeal tuberculosis carries a excellent prognosis, and complete resolution of disease is the rule.

Patil C; Kharat Patil R; Deshmukh P; Biswas J; John B

2013-03-01

64

Adenoid cystic carcinoma of sublingual glands. Surgery and radiotherapy combination  

International Nuclear Information System (INIS)

The Adenoid Cystic Carcinoma (ACC) or Cilindroma is a strange entity classified by the WHO within the carcinomas of salivary glands. It represents only 1 % of all the wicked tumours of the oral and maxillofacial region although, when making reference to the salivary glands, it constitutes 5% of the parotid, submaxilar and sublingual carcinomas, and about 50% of the smallest ones. The most frequent location is in the palatine glands and its main characteristics are: slow but persistent growth, high rates of local relapse and metastasis at distance originating the death between the first 5 and 10 years in 50-70% of the cases approximately. A case of localization is presented in sublingual gland which was first treated surgically and later with radiotherapy, obtaining good results. (author)

2005-01-01

65

The TIMP-1 expression in germinal centers of hypertrophied adenoids in children.  

UK PubMed Central (United Kingdom)

OBJECTIVES: The main aim of this study was to evaluate TIMP-1 expression in germinal centers of hypertrophied adenoids in children on the assumption that it can be treated as a marker of adenoidal tissue function. PATIENTS AND METHODS: The study involved 54 children undergoing adenoidectomy; divided into three age groups: aged up to 5 years (8 children), 5-10 years (31 children) and over 10 years (15 children). The analyzed material was adenoids removed on the ground of hypertrophy, which caused obstructive symptoms and/or otitis media with effusion onset. Immunohistochemical analyses were carried out using monoclonal mouse antibody (Ab) (Novocastra) directed against human TIMP-1 protein. The presence of TIMP-1 positive lymphocytes within germinal centers and TIMP-1 immunostaining were scored. RESULTS: The immunohistochemical staining showed the TIMP-1 positive lymphocytes mainly within the mantle zone. There was no statistically significant difference between the mean age of children for TIMP-1 immunoreaction levels. We have not found statistical correlation between the TIMP-1 staining and the clinical status of patients. CONCLUSION: It is difficult to interpret our results. Our findings did not demonstrate changes in TIMP-1 expression according to age. This may indicate that the processes of hyperplasia, hypertrophy and atrophy of adenoid are not influenced by age and support our thesis that adenoid involution is rather the effect of changes in the number of lymphoid follicles that changes in them. However there is a need for further observational studies of TIMPs and MMPs in adenoid tissue.

Musiatowiwcz M; Koda M; Sulkowski S

2013-03-01

66

Radiographic evaluation of adenoidal size in children with allergic perennial rhinitis: still the current method  

International Nuclear Information System (INIS)

Adenoid hypertrophy is known to be the most common cause of nasal obstruction in children; thus, adenoidectomy is one of the most commonly performed surgical procedures in children. Clinical assessment of adenoidal size is difficult, and objective measurement is desirable. The study included 39 children (17 girls and 22 boys, 5-9 years of age, mean age: 6.7 years) with signs of perennial allergic rhinitis and suspicion of adenoidal hypertrophy. To establish the best radiological method to measure the adenoidal size, three different procedures (Johanneson, Fuijoka, and Cohen/Konak) were used. The methods were evaluated against the degree to which the adenoids obstructed the nasopharyngeal space on flexible endoscopy of the postnasal space. Clinical symptomatology was also evaluated against the degree of obstruction. To estimate the correspondence between the results, we used Spearman's correlation test.The radiological method that best correlated with the endoscopic findings was that of Cohen and Konak, but neither radiology nor endoscopic scores correlated well with clinical symptoms. Conclusion: The side-adenoid assessment in allergic children. (author)

2005-01-01

67

Isolation of mesenchymal stromal cells (MSCs) from human adenoid tissue.  

UK PubMed Central (United Kingdom)

BACKGROUND: Mesenchymal stromal cells (MSCs) are multipotent progenitor cells that originally derived from bone marrow. Clinical use of bone marrow-derived MSC is difficult due to morbidity and low MSC abundance and isolation efficiency. Recently, MSCs have been isolated from various adult tissues. Here we report the isolation of adenoid tissue-derived MSCs (A-MSCs) and their characteristics. METHODS: We compared the surface markers, morphologies, and differentiation and proliferation capacities of previously established tonsil-derived MSCs (T-MSCs) and bone marrow-derived MSCs (BM-MSCs) with cells isolated from adenoid tissue. The immunophenotype of A-MSCs was investigated upon interferon (IFN)-? stimulation. RESULTS: A-MSCs, T-MSCs, and BM-MSCs showed negative CD45, CD31 HLA-DR, CD34, CD14, CD19 and positive CD 90, CD44, CD73, CD105 expression. A-MSCs were fibroblast-like, spindle-shaped non-adherent cells, similar to T-MSCs and BM-MSCs. Adipogenesis was observed in A-MSCs by the formation of lipid droplets after Oil Red O staining. Osteogenesis was observed by the formation of the matrix mineralization in Alizarin Red staining. Chondrogenesis was observed by the accumulation of sulfated glycosaminoglycan-rich matrix in collagen type II staining. These data were similar to those of T-MSCs and BM-MSCs. Expression of marker genes (i.e., adipogenesis; lipoprotein lipase, proliferator-activator receptor-gamma, osteogenesis; osteocalcin, alkaline phasphatase, chondrogenesis; aggrecan, collagen type II ?1) in A-MSCs were not different from those in T-MSCs and BM-MSCs. CONCLUSIONS: A-MSCs possess the characteristics of MSCs in terms of morphology, multipotent differentiation capacity, cell surface markers, and immunogeneity. Therefore, A-MSCs fulfill the definition of MSCs and represent an alternate source of MSCs.

Lee YS; Lee JE; Park HY; Lim YS; Lee JC; Wang SG; Lee BJ

2013-01-01

68

Neutron radiotherapy for adenoid cystic carcinoma of minor salivary glands  

International Nuclear Information System (INIS)

[en] Purpose: To examine the efficacy of fast neutron radiotherapy for the treatment of patients with locally advanced, adenoid cystic carcinoma of minor salivary glands and to identify prognostic variables associated with local control, overall survival, and cause specific survival. Methods and Materials: Eighty-four patients having adenoid cystic carcinoma of minor salivary glands were treated with fast neutron radiotherapy during the years 1985-1994. All patients had either unresectable disease or gross disease remaining after attempted surgical extirpation. Seventeen patients had previously received conventional radiotherapy and their subsequent treatment fields and doses for neutron radiotherapy were modified for critical sites (brainstem, spinal cord, brain). Although the median doses (tumor maximum and tumor minimum) only varied by ?10%, treatment portals were substantially smaller in these patients because of normal tissue complication considerations. Twelve patients (13%) had distant metastases at the time of treatment and were only treated palliatively with smaller treatment portals and lower median tumor doses (?80% of the doses delivered to curatively treated patients). Seventy-two patients were treated with curative intent, with nine of these having recurrent tumors after prior full-dose radiotherapy. The median duration of follow-up at the time of analysis was 31.5 months (range 3-115). Sites of disease and number of patients treated per disease site were as follows: paranasal sinus--31; oral cavity--20; oropharynx--12; nasopharynx--11; trachea--6; and other sites in the head and neck--4. Results: The 5-year actuarial local-regional tumor control rate for all patients treated with curative intent was 47%. Patients without involvement of the cavernous sinus, base of skull, or nasopharynx (51 patients) had a 5-year actuarial local-regional control rate of 59%, whereas local-regional control was significantly lower (15%) for patients with tumors involving these sites (p

1996-08-01

69

Neutron radiotherapy for adenoid cystic carcinoma of the lacrimal gland.  

UK PubMed Central (United Kingdom)

PURPOSE: Lacrimal gland adenoid cystic carcinomas are rare, aggressive orbital tumors that share histopathologic similarities with salivary gland malignancies. Neutron radiotherapy may be useful for treatment due to its high biological effectiveness for salivary malignancies. METHODS: The authors retrospectively reviewed the outcomes for 11 lacrimal gland adenoid cystic carcinoma patients treated with neutrons from 1988 to 2011. Most had undergone surgery prior to radiation therapy. However, gross residual disease was present in 8 patients. The most common American Joint Committee on Cancer stage was T4cN0M0. Four patients with skull base involvement received a radiosurgery boost and 1 received a proton therapy boost. RESULTS: Median follow up was 6.2 years. Median overall survival was 11.1 years and median disease-free survival was 6.3 years. Five-year local control was estimated by the Kaplan-Meier method as 80%. Three patients had a local recurrence; 4 developed distant metastases. Six patients died. Seven patients had intact vision in the affected eye before neutron radiation. Two required enucleation for a painful dry eye. Of the 5 who avoided an enucleation, 3 had either severe visual impairment (20/400) or only light perception and 2 were without known vision compromise or complications at the time of their death. One patient developed asymptomatic frontal lobe radionecrosis after 2 courses of radiation therapy. CONCLUSIONS: Neutron radiation therapy achieved excellent 5-year local control in this series of high-risk patients, with most cases having gross residual disease. Late recurrences and distant metastases remain a challenge. Meaningful ipsilateral vision preservation was not possible in most cases in the long term, although only 2 patients required an enucleation for treatment effects.

Gensheimer MF; Rainey D; Douglas JG; Liao JJ; Laramore GE; Jian-Amadi A; Chow LQ; Koh WJ; Parvathaneni U

2013-07-01

70

Evaluation of the relation between adenoids hypertrophy and cranial base angles  

Directory of Open Access Journals (Sweden)

Full Text Available Background and Aim: Adenoids are normally large in children and their size starts to reduce during adolescence. Hypertrophic adenoids could be associated with allergic reactions. Enlarged adenoids result in nasal breathing difficulties and the child is forced to switch to mouth breathing. Airway obstruction causes postural alterations of jaw, tongue and head, and due to persistent obstruction, patient’s appearance changes to adenoid face. Evaluation of nasopharyngeal space in lateral cephalometic view is a simple and repeatable method for determination of the size and shape of adenoids and nasopharyngeal space which can provide a simple measurement of nasopharyngeal obstruction. The roof of nasopharyngeal space is covered by the sphenoid bone. Thus changes of nasorespiratory resistance by hypertrophic adenoids may affect the cranial base angles. In this study, the relationship between adenoid hypertrophy and cranial base angles was investigated. Materials and Methods: In this descriptive-analytic study, lateral cephalometric views of 7 to 14 y/o patients from the files of orthodontic centers in Rasht city were selected. The radiographs with proper resolution were separated for this research. Adenoid to nasorespiratory ratio (A/N Ratio) was determined by Fujioka method and categorized in three groups: A (A/N 0.8), B (0.5adenoid hypertrophy (A and B groups) was observed in 66% of cases whereas 34% were normal. The frequency of narrow, normal and wide cranial base angles in lateral ceph views was 28%, 30% and 42% respectively. There was significant difference among different cranial base angle regarding the presence or absence of adenoid hypertrophy (P<0.001). According to Pearson coefficient, there was significant relation between A/N ratio groups and different cranial base angles (R=0.2). Conclusion: Based on the results of this study, little correlation exists between A/N ratio and cranial base angle. Further studies are recommended to investigate the possible effects of other factors such as genetics and the environment.

Dalili Z; Rahro Taban S; Vahedi MA

2006-01-01

71

Neutron radiotherapy for adenoid cystic carcinoma of minor salivary glands.  

UK PubMed Central (United Kingdom)

PURPOSE: To examine the efficacy of fast neutron radiotherapy for the treatment of patients with locally advanced, adenoid cystic carcinoma of minor salivary glands and to identify prognostic variables associated with local control, overall survival, and cause specific survival. METHODS AND MATERIALS: Eighty-four patients having adenoid cystic carcinoma of minor salivary glands were treated with fast neutron radiotherapy during the years 1985-1994. All patients had either unresectable disease or gross disease remaining after attempted surgical extirpation. Seventeen patients had previously received conventional radiotherapy and their subsequent treatment fields and doses for neutron radiotherapy were modified for critical sites (brainstem, spinal cord, brain). Although the median doses (tumor maximum and tumor minimum) only varied by < or = 10%, treatment portals were substantially smaller in these patients because of normal tissue complication considerations. Twelve patients (13%) had distant metastases at the time of treatment and were only treated palliatively with smaller treatment portals and lower median tumor doses (< or = 80% of the doses delivered to curatively treated patients). Seventy-two patients were treated with curative intent, with nine of these having recurrent tumors after prior full-dose radiotherapy. The median duration of follow-up at the time of analysis was 31.5 months (range 3-115). Sites of disease and number of patients treated per disease site were as follows: paranasal sinus-31; oral cavity-20; oropharynx-12; nasopharynx-11; trachea-6; and other sites in the head and neck-4. RESULTS: The 5-year actuarial local-regional tumor control rate for all patients treated with curative intent was 47%. Patients without involvement of the cavernous sinus, base of skull, or nasopharynx (51 patients) had a 5-year actuarial local-regional control rate of 59%, whereas local-regional control was significantly lower (15%) for patients with tumors involving these sites (p < 0.005). In the latter cases, normal tissue injury considerations precluded delivery of the full dose to the entire tumor. Patients with no history of prior radiotherapy (63 patients) had an actuarial local control rate of 57% at 5 years compared to 18% for those (9 patients) who had been previously irradiated with conventional photons (p = 0.018). Eliminating the dose-limiting factors of prior radiation therapy and/or high risk sites of involvement, the 5-year actuarial local-regional control rate for these 46 patients was 63%, with an actuarial cause specific survival rate of 79%. Lymph node status was a predictor of distant metastasis: 57% of node positive patients developed distant metastases by 5 years compared to 15% of patients with negative nodes (p < 0.0005), and patients who had nodal involvement developed distant metastases sooner than node negative patients (p < 0.0001). The 5-year actuarial overall survival and cause specific survival for the 72 patients treated with curative intent were 59% and 64%, respectively. CONCLUSIONS: Fast neutron radiotherapy offers high local-regional control and survival rates for patients with locally advanced, unresectable adenoid cystic carcinomas of minor salivary glands. It should be considered as initial primary treatment for these patients, as well as for other patients in whom surgical extirpation would cause considerable morbidity.

Douglas JG; Laramore GE; Austin-Seymour M; Koh WJ; Lindsley KL; Cho P; Griffin TW

1996-08-01

72

Radiologic evaluation of adenoids and tonsils in children with obstructive sleep apnea: Plain films and fluoroscopy  

International Nuclear Information System (INIS)

[en] Twenty-six children with obstructive sleep apnea were evaluated by lateral neck radiographs during wakefulness, and by polygraphic monitoring and upper airway fluoreoscopy during natural sleep. Children with craniofacial abnormalities, palatal surgery, and central nervous system disease were excluded from the study. Moderate or marked enlargement of tonsils and adenoids was noted on lateral neck radiographs of 18 of 26 patients. An objective measure of adenoidal enlargement, the adenoidal-nasopharyngeal ratio, correlated well with subjective judgment of adenoidal size but was not generally more useful than subjective estimation. Upper airway fluroescopy demonstrated the site and mechanism of obstruction in all patients. Because all children with moderate to marked adenotonsillar enlargement demonstrated obstruction at the adenoidal or tonsillar level on fluoroscopy, we now screen children with suspected sleep apnea with lateral airway radiographs and polysomnography. Fluoroscopy is reserved for children with mild adenotosillar enlargement, craniofacial dysplasia, prior cleft palate repair, or neuromuscular disorders. These results suggest that the pathogenesis of obstuctive sleep apnea in children involve anatomic factors which narrow the upper airway, sleep-related hypotonia of pharyngeal dilator musculature, and compensatory mechanisms to prevent or alleviate asphyxia. (orig.)

1983-01-01

73

Diagnostic efficacy of different methods in the assessment of adenoid hypertrophy.  

UK PubMed Central (United Kingdom)

OBJECTIVE: This study was designed for better understanding of the role of different methods of nasal endoscopy in the assessment of adenoid hypertrophy and comparing them with lateral neck radiography and patients' symptoms. SUBJECTS AND METHOD: From August 2007 until January 2009, in the otolaryngology ward of a tertiary referral center, 89 patients who had symptoms related to chronic mouth breathing participated in this study. History of the symptoms related to adenoid hypertrophy was obtained from them. In addition, all patients underwent nasal endoscopy and lateral nasopharynx x-ray. The clinician who did nasal endoscopy was blinded to information about clinical data and x-ray and vice versa. Afterward, the relationship between symptoms and each diagnostic procedure was evaluated. RESULTS: Patients had a mean age of 9.47 ± 4.68 years. In the evaluation of the relationship between symptoms grading and grading in lateral neck radiography, this relationship was significant about snoring. Furthermore, there was a significant relationship between the endoscopic size of adenoid and number of the episodes of acute otitis media. The sum of symptoms grading had a significant relationship with the size of adenoid in lateral neck x-ray, but not in nasal endoscopy. CONCLUSION: The results of the present study indicated that both radiography and nasal endoscopy could define the relationship between adenoid hypertrophy and associated symptoms and therefore are complementary. Between them, despite the popularity of nasal endoscopy, radiography can serve as a better planning tool.

Saedi B; Sadeghi M; Mojtahed M; Mahboubi H

2011-03-01

74

Lapatinib in Treating Patients With Recurrent and/or Metastatic Adenoid Cystic Cancer or Other Salivary Gland Cancers  

Science.gov (United States)

High-grade Salivary Gland Carcinoma; High-grade Salivary Gland Mucoepidermoid Carcinoma; Low-grade Salivary Gland Carcinoma; Low-grade Salivary Gland Mucoepidermoid Carcinoma; Recurrent Adenoid Cystic Carcinoma of the Oral Cavity; Recurrent Salivary Gland Cancer; Salivary Gland Acinic Cell Tumor; Salivary Gland Adenocarcinoma; Salivary Gland Adenoid Cystic Carcinoma; Salivary Gland Malignant Mixed Cell Type Tumor

2013-05-07

75

Topographic distribution of biofilm-producing bacteria in adenoid subsites of children with chronic or recurrent middle ear infections.  

UK PubMed Central (United Kingdom)

OBJECTIVES: Bacterial biofilms have been found in the adenoids of children with recurrent acute otitis media (AOM) and persistent otitis media with effusion (OME). However, the possible difference in biofilm-producing bacteria (BPBs) between the adenoid surface at the nasopharyngeal dome (ND) and near the ostium of the eustachian tube (ET) has not been investigated. This study aimed to assess the difference in BPBs between adenoid biopsy specimens of the ND and those taken near the pharyngeal ostium of the ET in children with chronic adenoiditis with recurrent AOM and/or persistent OME. METHODS: We collected adenoid biopsy specimens from the ND and ET during transoral endoscopic adenoidectomy to assess BPB by means of spectrophotometric analysis. RESULTS: We collected 135 adenoid biopsy specimens from 45 children. BPBs were detected significantly (p = 0.04) more frequently in the ET samples than in the ND samples, mainly Staphylococcus aureus. Although the prevalence of S aureus was slightly greater in the ND samples, and that of Streptococcus pneumoniae and Moraxella catarrhalis was slightly greater in the ET samples, these differences were not statistically significant. CONCLUSIONS: The fact that BPBs were significantly more frequently located near the ostium of the ET suggests that the adenoids are a reservoir for bacteria and indicates that hypertrophic adenoids (particularly hypertrophy near the ostium of the ET) play a role in recurrent AOM and/or OME.

Torretta S; Drago L; Marchisio P; Gaffuri M; Clemente IA; Pignataro L

2013-02-01

76

Adenoid cystic carcinoma of the head and neck  

International Nuclear Information System (INIS)

Between 1976 and 1999, 10 patients with adenoid cystic carcinoma of the head and neck were treated in our department. The patients consisted of 20 females and 20 males. The overall 5-year and 10-year survival rates determined, by Kaplan-Meier analysis, were 74.8% and 47.4%, respectively. The 10-year survival rate of stage I-II was 75.0%, and that of stage III-IV was 33.6%. The prognosis of the patients with stage III-IV was relatively poor. The 10-year survival rates of the patients with nasal and paranasal tumors, and those with maxillary sinus tumors were 25.0% and 0%, respectively. The 10-year survival rate of 15 patients that received combined surgery and radiotherapy was 44.0%, while that of 21 patients that received surgery alone was 48.6%. There was no statistical significance between the two. It was effective, for the patients with lung metastases, to perform pulmonary surgery, for progmosis improvement. We concluded that obtaining clear margins at the initial surgery appeared to be associated with improved survival, combined radiation of less than 50 Gy was not effective, patients with pulmonary metastasis should be treated, if possible. (author)

2001-01-01

77

Adenoid cystic carcinoma of the external auditory canal.  

UK PubMed Central (United Kingdom)

Primary cancers of the external auditory canal (EAC) are rare and most are squamous cell carcinomas. We report the case of a 78-year-old man who visited our institution with a 5-month history of right-side intermittent otalgia and ear fullness. Otoscopic examination showed a bulging mass arising from the superior and posterior aspects of the right EAC, and incision biopsy confirmed the lesion as adenoid cystic carcinoma (ACC). Lateral temporal bone resection in conjunction with total parotidectomy and neck dissection was subsequently performed. Postoperative adjuvant radiotherapy was administered and no recurrence was noted at a 26-month follow-up. We review the medical literature on the topic and suggest that early diagnosis is still the best option for successful treatment of this neoplasm. ACC arising in the EAC must be removed using radical procedures to increase the chance of local control. Subsequent metastasis that tends to develop in the lungs and regional lymph nodes is best evaluated regularly using computed tomography examination.

Liu SC; Kang BH; Nieh S; Chang JL; Wang CH

2012-06-01

78

Adenoid cystic carcinoma of the external auditory canal.  

Science.gov (United States)

Primary cancers of the external auditory canal (EAC) are rare and most are squamous cell carcinomas. We report the case of a 78-year-old man who visited our institution with a 5-month history of right-side intermittent otalgia and ear fullness. Otoscopic examination showed a bulging mass arising from the superior and posterior aspects of the right EAC, and incision biopsy confirmed the lesion as adenoid cystic carcinoma (ACC). Lateral temporal bone resection in conjunction with total parotidectomy and neck dissection was subsequently performed. Postoperative adjuvant radiotherapy was administered and no recurrence was noted at a 26-month follow-up. We review the medical literature on the topic and suggest that early diagnosis is still the best option for successful treatment of this neoplasm. ACC arising in the EAC must be removed using radical procedures to increase the chance of local control. Subsequent metastasis that tends to develop in the lungs and regional lymph nodes is best evaluated regularly using computed tomography examination. PMID:22721626

Liu, Shao-Cheng; Kang, Bor-Hwang; Nieh, Shin; Chang, Junn-Liang; Wang, Chih-Hung

2012-05-31

79

Effect of amoxycillin with or without clavulanate on adenoid bacterial flora.  

Science.gov (United States)

The effect of antimicrobial therapy with amoxycillin (AMX) or co-amoxiclav (AMC) on the adenoid bacterial flora of 45 children with recurrent otitis media (ROM), scheduled for elective adenoidectomy, was studied. Patients were randomized before surgery into three groups of 15, having had either no antibiotic therapy (control), or 10 days of therapy with AMX or AMC. Core adenoid tissues were quantitatively cultured for aerobic and anaerobic bacteria. Polymicrobial aerobic-anaerobic flora was present in all instances. The predominant aerobes in all groups were alpha-haemolytic and non-haemolytic streptococci, Haemophilus influenzae, Staphylococcus aureus, group A beta-haemolytic streptococci and Moraxella catarrhalis. The prominent anaerobes were Peptostreptococcus spp., Prevotella spp. and Fusobacterium spp. The number of isolates was significantly reduced in those treated with AMX (110; P BLPB) was lower in those treated with AMC compared with those treated with AMX (P BLPB from the adenoids of children with ROM. PMID:11481299

Brook, I; Shah, K

2001-08-01

80

Neutron radiotherapy for adenoid cystic carcinoma of the head and neck.  

UK PubMed Central (United Kingdom)

Achieving local control in patients with advanced adenoid cystic carcinoma continues to be a therapeutic challenge. From 1984 to 1990, we treated 34 patients with advanced adenoid cystic carcinoma of the head and neck with fast neutron radiation. Patients treated for minimal microscopic disease following surgery were not included in this study. Neutron radiotherapy achieved 5-year actuarial local control and locoregional control rates of 76% and 63%, respectively. Five-year actuarial overall survival and disease-specific survival rates were 65% and 93%, respectively. Eighty-one percent (17/21) of patients treated with neutron therapy alone and 100% (13/13) of the patients treated with neutron therapy and surgery achieved local control. All seven patients with paranasal sinus malignant neoplasms achieved local control. The success achieved in this prognostically unfavorable population affirms the important role of neutron radiotherapy in the treatment of adenoid cystic carcinoma.

Buchholz TA; Shimotakahara SG; Weymuller EA Jr; Laramore GE; Griffin TW

1993-07-01

 
 
 
 
81

Neutron radiotherapy for adenoid cystic carcinoma of the head and neck.  

Science.gov (United States)

Achieving local control in patients with advanced adenoid cystic carcinoma continues to be a therapeutic challenge. From 1984 to 1990, we treated 34 patients with advanced adenoid cystic carcinoma of the head and neck with fast neutron radiation. Patients treated for minimal microscopic disease following surgery were not included in this study. Neutron radiotherapy achieved 5-year actuarial local control and locoregional control rates of 76% and 63%, respectively. Five-year actuarial overall survival and disease-specific survival rates were 65% and 93%, respectively. Eighty-one percent (17/21) of patients treated with neutron therapy alone and 100% (13/13) of the patients treated with neutron therapy and surgery achieved local control. All seven patients with paranasal sinus malignant neoplasms achieved local control. The success achieved in this prognostically unfavorable population affirms the important role of neutron radiotherapy in the treatment of adenoid cystic carcinoma. PMID:8391275

Buchholz, T A; Shimotakahara, S G; Weymuller, E A; Laramore, G E; Griffin, T W

1993-07-01

82

Avaliação da radiografia cefalométrica lateral como meio de diagnóstico da hipertrofia de adenoide Evaluation of lateral cephalometric radiography as a mean of diagnosing adenoids hypertrophy  

Directory of Open Access Journals (Sweden)

Full Text Available INTRODUÇÃO: a hipertrofia de adenoide é uma das principais causas da respiração bucal. Entre os métodos utilizados para o diagnóstico dessa condição, os mais precisos são a endoscopia nasal e a ressonância magnética. No entanto, o método mais utilizado, em Odontologia, é a radiografia cefalométrica lateral. OBJETIVO: determinar a eficácia dessa radiografia no diagnóstico da hipertrofia de adenoide, pela sua comparação com a endoscopia nasal. MÉTODOS: foram avaliados 30 indivíduos (7 a 12 anos). Todos fizeram exame de endoscopia nasal e radiografia cefalométrica lateral. Nas endoscopias, foi registrada a porcentagem de obstrução da nasofaringe e, nas radiografias, a menor dimensão anteroposterior livre da nasofaringe. RESULTADOS: os exames se mostraram fortemente correlacionados (r = - 0,793, p-valor INTRODUCTION: One of the most usual causes of mouth breathing is adenoids hypertrophy with reduction of the nasopharyngeal space. The most precise diagnostic methods are magnetic resonance and nasal endoscopy, because they make possible a three dimension image of the nasopharynx. However, in Dentistry, cephalometric radiography is the method used in the majority of cases. That is why it is so important the evaluation of the efficacy of this diagnostic method. AIM: The aim of this paper is to determine the efficacy of the lateral cephalometric radiography in diagnosing adenoids hypertrophy, comparing this method to the nasal endoscopy. METHODS: Thirty patients (7 to 12 years), with no history of otolaryngological surgery, were evaluated. All of them were submitted to a nasal endoscopy and a lateral cephalometric radiography. In the endoscopic exams it was registered the percentage of nasopharyngeal obstruction and in the radiographic exams it was registered the minor nasopharyngeal dimension. RESULTS: The results of the exams showed a strong correlation with each other (r = - 0.793, p-value < 0.01). After that, reliability tests to the radiographic diagnose were performed, assuming that 75% (endoscopic exams) and 5mm (radiographic exams) were the limit values to the determination of the diagnose of severe adenoids hypertrophy. The radiographic exam showed a sensibility of 75%, specificity of 86.3%, positive predictive value of 66.7%, negative predictive value of 90.4% and an exactness of 83.3%. Therefore, lateral cephalometric radiography is an efficient method of adenoids hypertrophy diagnose. It was proved by the strong correlation of its results with the results of the nasal endoscopy, that is considered a method of excellence for diagnosing this condition.

Marcelo de Castellucci e Barbosa; Luégya Amorim Henriques Knop; Marcus Miranda Lessa; Telma Martins de Araujo

2009-01-01

83

Carcinoma adenoide cístico do conduto auditivo externo com envolvimento de mastoide  

Directory of Open Access Journals (Sweden)

Full Text Available Introdução: O carcinoma adenoide cístico (CAC) no conduto auditivo externo é raro, tendo origem nas glândulas ceruminosas. Manifesta-se por otalgia em cerca de 90% dos pacientes. Relato do Caso: Neste artigo relatamos o caso de um paciente com Carcinoma Adenoide Cístico de conduto auditivo externo com envolvimento de mastoide que apresentava paralisia facial periférica. O tratamento é essencialmente cirúrgico, combinado ou não com radioterapia pós-operatória. Os fatores de mau prognóstico são a extensão do tumor, invasão do nervo facial e orelha média e acometimento linfonodal, diminuindo a sobrevida em cinco anos de 59% para 23%.

Tinoco, Paulo; Lourenço Filho, Rodolfo Caldas; Pais, Daniela Silva; Silva, Fabrício Boechat do Carmo; Pereira, José Carlos Oliveira; Pontes, Lorena Luquetti

2009-01-01

84

Avaliação da radiografia cefalométrica lateral como meio de diagnóstico da hipertrofia de adenoide/ Evaluation of lateral cephalometric radiography as a mean of diagnosing adenoids hypertrophy  

Scientific Electronic Library Online (English)

Full Text Available Abstract in portuguese INTRODUÇÃO: a hipertrofia de adenoide é uma das principais causas da respiração bucal. Entre os métodos utilizados para o diagnóstico dessa condição, os mais precisos são a endoscopia nasal e a ressonância magnética. No entanto, o método mais utilizado, em Odontologia, é a radiografia cefalométrica lateral. OBJETIVO: determinar a eficácia dessa radiografia no diagnóstico da hipertrofia de adenoide, pela sua comparação com a endoscopia nasal. MÉTODOS: f (more) oram avaliados 30 indivíduos (7 a 12 anos). Todos fizeram exame de endoscopia nasal e radiografia cefalométrica lateral. Nas endoscopias, foi registrada a porcentagem de obstrução da nasofaringe e, nas radiografias, a menor dimensão anteroposterior livre da nasofaringe. RESULTADOS: os exames se mostraram fortemente correlacionados (r = - 0,793, p-valor Abstract in english INTRODUCTION: One of the most usual causes of mouth breathing is adenoids hypertrophy with reduction of the nasopharyngeal space. The most precise diagnostic methods are magnetic resonance and nasal endoscopy, because they make possible a three dimension image of the nasopharynx. However, in Dentistry, cephalometric radiography is the method used in the majority of cases. That is why it is so important the evaluation of the efficacy of this diagnostic method. AIM: The aim (more) of this paper is to determine the efficacy of the lateral cephalometric radiography in diagnosing adenoids hypertrophy, comparing this method to the nasal endoscopy. METHODS: Thirty patients (7 to 12 years), with no history of otolaryngological surgery, were evaluated. All of them were submitted to a nasal endoscopy and a lateral cephalometric radiography. In the endoscopic exams it was registered the percentage of nasopharyngeal obstruction and in the radiographic exams it was registered the minor nasopharyngeal dimension. RESULTS: The results of the exams showed a strong correlation with each other (r = - 0.793, p-value

Barbosa, Marcelo de Castellucci e; Knop, Luégya Amorim Henriques; Lessa, Marcus Miranda; Araujo, Telma Martins de

2009-08-01

85

The aryepiglottic fold as a rare location of adenoid cystic carcinoma.  

UK PubMed Central (United Kingdom)

We report one case of a mass in the aryepiglottic fold seen on CT, which proved to be an adenoid cystic carcinoma. There was nothing specific about the imaging characteristics that would allow it to be confidentially differentiated from squamous cell carcinoma.

de Kerviler E; Bely N; Laccourreye O; Clément O; Halimi P; Frija G

1995-06-01

86

Adenoid cystic carcinoma of the external auditory canal with pulmonary, renal and liver metastases.  

Directory of Open Access Journals (Sweden)

Full Text Available We report a patient with adenoid cystic carcinoma of the external auditory canal with multiple pulmonary, liver and renal secondaries. She had a palpable left renal mass. The clinical course and treatment of this unusual neoplasm as reported in literature are briefly reviewed.

Matthew R; Subhashini J; Ponnaiya J; Sridhar G; Roul R

1997-01-01

87

Brain and lung metastasis of Bartholin's gland adenoid cystic carcinoma: a case report  

Science.gov (United States)

Introduction Adenoid cystic carcinoma of Bartholin’s gland is a very rare disease. Case presentation A 48-year-old premenopausal woman of Caucasian origin was delivered adjuvant pelvic and inguinal radiotherapy after prior complete left Bartholin’s gland tumor excision and inguinal lymph node dissection for adenoid cystic carcinoma of Bartholin’s gland with one metastatic inguinal lymph node. Two years after primary treatment, she presented to the Emergency Room with acute headache, hypoacousia, decrease in visual acuity, and a decrease in right leg muscle strength. A cranial magnetic resonance imaging scan demonstrated three cystic brain lesions with associated perifocal edema. Chest and abdomen computed tomography scans and a magnetic resonance imaging scan of the pelvis did not find any metastatic or residual disease elsewhere. A physical examination found no local recurrence. Stereotactic brain biopsies with pathology examination revealed the presence of adenoid cystic carcinoma metastasis. She thus received 30Gy of brain radiotherapy but, three months later, the brain lesions did not decrease in size and left mid lobular lung lesions appeared on her chest computed tomography scan. A mid left lobe lung excision was undertaken followed by chemotherapy consisting of six cycles of cyclophosphamide, adriamycin and cisplatin. Five months after beginning chemotherapy, the brain disease progressed and our patient died. Conclusion Our case report shows the difficulty in managing brain and lung metastasis of Bartholin’s gland adenoid cystic carcinoma as no consensus on the optimal treatment exists.

2013-01-01

88

[Clinical study on 88 cases of adenoid cystic carcinoma in nasal cavity and paranasal sinuses].  

UK PubMed Central (United Kingdom)

OBJECTIVE: To study the clinical characters, diagnosis, management and prognosis of patients with adenoid cystic carcinoma in nasal cavity and paranasal sinuses. METHODS: The data were analyzed retrospectively for 88 patients with adenoid cystic carcinoma in nasal cavity and paranasal sinuses, to evaluate the clinical characters, diagnostic and therapeutical aspects and the contribution of every factor influencing the survival. Survival analysis was performed by Kaplan-Meier method, comparison among/between groups was performed using Log-rank test, and multivariate analysis was carried out using Cox proportional hazard model. RESULTS: There were 56 patients in stage III and IV. Most of them received surgical operation combined with radiotherapy. The 5-year, 10-year and 15-year survival rates were 0.640, 0.341 and 0.190 respectively. While there were only 0.833, 0.221 and 0.323, 0.145 in stage III and stage IV lesions respectively. The 5-year and 10-year survival rates of 0.761, 0.415 were obtained in patients who received surgery combined with radiotherapy, 0.750, 0.367 and 0.286, 0.143 respectively in those treated by surgery and by radiotherapy alone. CONCLUSIONS: Advanced adenoid cystic carcinoma should be treated by combined surgical operation and radiotherapy. Stage and treatment approach are the independent factors affecting the prognoses of patients with adenoid cystic carcinoma in nasal cavity and paranasal sinuses.

Zhang Q; Yang L; Yang AK; Guo ZM

2009-04-01

89

[Clinical study of 36 cases with adenoid cystic carcinoma of the maxillary sinus].  

UK PubMed Central (United Kingdom)

OBJECTIVE: To study the clinical characters, management and the prognosis of patients with adenoid cystic carcinoma of the maxillary sinus. METHODS: The clinical data were analyzed retrospectively for 36 patients with adenoid cystic carcinoma of the maxillary sinus to evaluate the treatment results of different modalities. The contribution of every factors influencing on survival were also analyzed. Survival analysis was performed by life table method, comparison among/between groups was performed using log-rank test, and multivariate analysis was carried out using Cox proportional hazard model. RESULTS: The 5-year survival rate was 58.33% in all patients, while they were only 75.0% and 42.9% in stage III and stage IV lesions respectively. The 5-year survival rate of 66.7% was obtained in patients who received surgery combined with radiotherapy,71.4% and 12.5% respectively in those treated by surgery and by radiotherapy alone. Multivariate analysis indicated that stage, treatment modality, and the tumour residues in the primary treatment were the predict factors for the prognosis. CONCLUSIONS: Advanced adenoid cystic carcinoma should be treated by combined surgery and radiotherapy. Stage, treatment approach and short-term therapeutic response are the most important factors affecting the prognosis of the patients with adenoid cystic carcinoma of the maxillary sinus.

Liu TR; Chen FJ; Yang AK; Li QL; Guo ZM; Zhang Q; Zeng ZY

2008-01-01

90

THE PRESENCE OF ADENOID VEGETATIONS AND NASAL SPEECH, AND HEARING LOSS IN RELATION TO SECRETORY OTITIS MEDIA  

Directory of Open Access Journals (Sweden)

Full Text Available This study presents the treatment of 68 children with secretory otitis media. Children underwent adenoid vegetations, nasal speech, conductive hearing loss, ventilation disturbance in Eustachian tube. In all children adenoidectomy was indicated.38 boys and 30 girls at the age of 3-17 were divided in two main groups: * 29 children without hypertrophic (enlarged) adenoids, * 39 children with enlarged (hypertrophic) adenoids.The surgical treatment included insertion of ventilation tubes and adenoidectomy where there where hypertrophic adenoids.Clinical material was analyzed according to hearing threshold, hearing level, middle ear condition estimated by pure tone audiometry and tympanometry before and after treatment. Data concerning both groups were compared.The results indicated that adenoidectomy combined with the ventilation tubes facilitates secretory otitis media heeling as well as decrease of hearing impairments. That enables prompt restoration of the hearing function as an important precondition for development of the language, social, emotional and academic development of children.

Gabriela KOPACHEVA; Marina CHAKAR; Lidija DUBROVSKA

2004-01-01

91

Southwest Oncology Group study of mitoxantrone for treatment of patients with advanced adenoid cystic carcinoma of the head and neck.  

Science.gov (United States)

Eighteen patients are evaluable for response in a Phase II trial of Mitoxantrone for advanced adenoid cystic carcinoma of the head and neck. One patient had a complete response; there were no partial responses. Twelve patients had stable disease for 3 or more months. There was no significant anti-tumor activity of Mitoxantrone in the group of patients with adenoid cystic carcinoma, all of whom were previously heavily treated with surgery, chemotherapy and/or radiation therapy. PMID:2160919

Mattox, D E; Von Hoff, D D; Balcerzak, S P

1990-02-01

92

Partial remission of advanced adenoid cystic carcinoma obtained with adriamycin: a case report with a review of the literature.  

Science.gov (United States)

Adenoid cystic carcinoma is relatively uncommon and often originates from the salivary glands. Although distant metastases develop rather frequently no satisfactory form of therapy has been reported. We achieved a partial remission with adriamycin in a patient with advanced metastases of adenoid cystic carcinoma. This case is described, and a short review of the literature, including papers on the treatment of advanced disease, is also given. PMID:221094

Vermeer, R J; Pinedo, H M

1979-05-01

93

Southwest Oncology Group study of mitoxantrone for treatment of patients with advanced adenoid cystic carcinoma of the head and neck.  

UK PubMed Central (United Kingdom)

Eighteen patients are evaluable for response in a Phase II trial of Mitoxantrone for advanced adenoid cystic carcinoma of the head and neck. One patient had a complete response; there were no partial responses. Twelve patients had stable disease for 3 or more months. There was no significant anti-tumor activity of Mitoxantrone in the group of patients with adenoid cystic carcinoma, all of whom were previously heavily treated with surgery, chemotherapy and/or radiation therapy.

Mattox DE; Von Hoff DD; Balcerzak SP

1990-02-01

94

Partial remission of advanced adenoid cystic carcinoma obtained with adriamycin: a case report with a review of the literature.  

UK PubMed Central (United Kingdom)

Adenoid cystic carcinoma is relatively uncommon and often originates from the salivary glands. Although distant metastases develop rather frequently no satisfactory form of therapy has been reported. We achieved a partial remission with adriamycin in a patient with advanced metastases of adenoid cystic carcinoma. This case is described, and a short review of the literature, including papers on the treatment of advanced disease, is also given.

Vermeer RJ; Pinedo HM

1979-05-01

95

Adenoid cystic carcinoma of the tongue base treated with ultrasound-guided interstitial photodynamic therapy: a case study.  

Science.gov (United States)

Adenoid cystic carcinoma is a malignant neoplasm arising from the salivary glands. It accounts for 10-15% of all salivary gland neoplasms, representing 1-2% of malignant neoplasms of the head and neck. It is characterized by slow growth, diffuse invasion and potential to produce distant metastases, mainly to the lungs and bone. We present a case of adenoid cystic carcinoma of the base of tongue treated with ultrasound guided transcutaneous interstitial photodynamic therapy (PDT) as a salvage treatment. PMID:21333938

Osher, Jonas; Jerjes, Waseem; Upile, Tahwinder; Hamdoon, Zaid; Morley, Simon; Hopper, Colin

2010-09-15

96

Detection of atypical metastases in recurrent adenoid cystic carcinoma of parotid gland.  

UK PubMed Central (United Kingdom)

We report a known case of adenoid cystic carcinoma of right parotid gland in a 36-year-old Indian male, diagnosed 5 years ago for which he underwent surgery followed by radiotherapy. Now the patient has presented to the surgical oncologist with a mass near angle of right jaw. Computed tomography (CT) performed elsewhere was reported negative for local recurrence. Subsequently, 18 F Fluorodeoxyglucose positron emission tomography-CT (FDG PET-CT) demonstrated local recurrence in right parotid bed. Surprisingly, metabolically active metastatic skeletal deposits were also identified, thus the disease was upstaged and management was changed. Trucut biopsy from left iliac bone lesion confirmed metastases from adenoid cystic carcinoma. Thus a whole body PET-CT has a significant impact on management of patients with salivary gland malignancies in assessing both local recurrence as well as distant metastases, especially in atypical and unsuspected sites.

Tewari A; Padma S; Sundaram PS

2013-01-01

97

Multidisciplinary Management of Primary Adenoid Cystic Carcinoma of the Eyelid With Perineural Invasion.  

UK PubMed Central (United Kingdom)

Primary cutaneous adenoid cystic carcinoma of the eyelid is an extremely rare entity with the propensity to recur locally, spread to regional lymph nodes, and invade perineural spaces. Of the 8 cases previously reported in the literature, only 2 were noted to be associated with perineural invasion, and neither of these was treated with radiation therapy. The authors report the case of a 35-year-old woman who presented with a progressively enlarging left lower eyelid lesion. An excisional biopsy with wide margins revealed a diagnosis of primary adenoid cystic carcinoma of the eyelid with perineural invasion. Because of the high risk of recurrence associated with perineural invasion, the patient received postoperative adjuvant radiation in the form of 50 Gy relative biological effectiveness of proton beam therapy to the postoperative tumor bed and to the infraorbital nerve tracking back to the apex of the orbit, followed by a 10-Gy boost to the lower eyelid tumor bed with orthovoltage x-rays.

Bui M; Frank SJ; Nasser QJ; El Sawy T; McLemore MS; Morrison WH; Esmaeli B

2013-02-01

98

Carcinoma adenóide cístico de conduto auditivo externo Adenoid cystic carcinoma of the external auditory canal  

Directory of Open Access Journals (Sweden)

Full Text Available O carcinoma adenóide cístico é um raro tumor originado das glândulas salivares, principalmente quando se localiza no conduto auditivo externo. Apresenta alta taxa de invasão perineural e metástases, devendo ser tratado com combinação de cirurgia agressiva seguida de radioterapia. Relatamos um caso de carcinoma adenóide cístico de conduto auditivo externo em paciente de 77 anos com queixa de hipoacusia e otalgia. A mesma foi tratada com mastoidectomia radical e radioterapia.Adenoid cystic carcinoma is a rare tumor originating from the salivary glands, especially when arise the external auditory canal. This tumor has high rate of perineural invasion and metastasis, then must be treated with aggressive surgery combined with postoperative radiation. We report a case of an adenoid cystic carcinoma arising the external auditory canal of 77 years old female patient, who complained hypoacusis and pain. She was treated by radical mastoidectomy and radiotherapy.

Carolina Pimenta Carvalho; Alano Nunes Barcellos; Daniel Caldeira Teixeira; Juliano de Oliveira Sales; Rui da Silva Neto

2008-01-01

99

Carcinoma adenóide cístico de conduto auditivo externo/ Adenoid cystic carcinoma of the external auditory canal  

Scientific Electronic Library Online (English)

Full Text Available Abstract in portuguese O carcinoma adenóide cístico é um raro tumor originado das glândulas salivares, principalmente quando se localiza no conduto auditivo externo. Apresenta alta taxa de invasão perineural e metástases, devendo ser tratado com combinação de cirurgia agressiva seguida de radioterapia. Relatamos um caso de carcinoma adenóide cístico de conduto auditivo externo em paciente de 77 anos com queixa de hipoacusia e otalgia. A mesma foi tratada com mastoidectomia radical e radioterapia. Abstract in english Adenoid cystic carcinoma is a rare tumor originating from the salivary glands, especially when arise the external auditory canal. This tumor has high rate of perineural invasion and metastasis, then must be treated with aggressive surgery combined with postoperative radiation. We report a case of an adenoid cystic carcinoma arising the external auditory canal of 77 years old female patient, who complained hypoacusis and pain. She was treated by radical mastoidectomy and radiotherapy.

Carvalho, Carolina Pimenta; Barcellos, Alano Nunes; Teixeira, Daniel Caldeira; Sales, Juliano de Oliveira; Silva Neto, Rui da

2008-10-01

100

Prosthetic rehabilitation of a patient with adenoid cystic carcinoma with continuous orbital-maxillary defect.  

UK PubMed Central (United Kingdom)

Extensive head and neck surgical procedures severely affect vital functions, physical appearance and lead to huge psychological trauma in the patients. Well-constructed maxillofacial prosthesis will help them lead a normal social life for the remaining precious time. This case report explains the prosthetic rehabilitation of continuous orbital-maxillary surgical defect in a patient with adenoid cystic carcinoma with restricted mouth opening. Maxillofacial prosthesis needs individual modification to a treatment plan according to the defect and existing clinical conditions. In this case, magnetically retained three-piece prosthesis was designed because of high recurrence rate of the adenoid cystic carcinoma, lack of adequate bone for implants and limited mouth opening in the patient. The prosthesis restored the phonetics, aesthetics and deglutition of the patient by re-establishing the separation of oral-nasal-orbital cavities.

Haralur SB; Shah FK

2013-01-01

 
 
 
 
101

Twenty two year survival after incomplete resection of advanced adenoid cystic bronchogenic carcinoma.  

UK PubMed Central (United Kingdom)

In 1972, a 42 year old patient underwent thoracotomy for adenoid cystic carcinoma of the left main-stem bronchus. Pneumonectomy was performed, but the resection was not complete as the tumour had invaded the aortic and tracheal wall. The patient did not receive postoperative radiotherapy. In 1993, the patient was readmitted with severe respiratory insufficiency due to complete endobronchial tumour obstruction of the intermediate bronchus and extensive tumour growth in the mediastinum. Endobronchial laser treatment followed by stent implantation led to immediate symptomatic relief. The tumour then responded well to combined endobronchial and percutaneous radiotherapy. The patient died 7 months after readmission from ileus due to pancreatitis. We conclude that patients with advanced adenoid cystic carcinoma may profit from palliative surgery with respect not only to symptoms but also to duration of life.

Schoenfeld N; Rahn W; Loddenkemper R

1996-07-01

102

Twenty two year survival after incomplete resection of advanced adenoid cystic bronchogenic carcinoma.  

Science.gov (United States)

In 1972, a 42 year old patient underwent thoracotomy for adenoid cystic carcinoma of the left main-stem bronchus. Pneumonectomy was performed, but the resection was not complete as the tumour had invaded the aortic and tracheal wall. The patient did not receive postoperative radiotherapy. In 1993, the patient was readmitted with severe respiratory insufficiency due to complete endobronchial tumour obstruction of the intermediate bronchus and extensive tumour growth in the mediastinum. Endobronchial laser treatment followed by stent implantation led to immediate symptomatic relief. The tumour then responded well to combined endobronchial and percutaneous radiotherapy. The patient died 7 months after readmission from ileus due to pancreatitis. We conclude that patients with advanced adenoid cystic carcinoma may profit from palliative surgery with respect not only to symptoms but also to duration of life. PMID:8836673

Schoenfeld, N; Rahn, W; Loddenkemper, R

1996-07-01

103

[A clinical study on the adenoid cystic carcinoma in oral cavity  

UK PubMed Central (United Kingdom)

Two cases of adenoid cystic carcinoma occurred on the palate are reported. They were female and aged 65 and 69 year. They showed expansile growth in association with the bony destruction of maxillary sinus wall. Histologically the case 1 had cribriform pattern and the case 2 had cribriform and tubular pattern, and exhibited perineural invasion of tumor cells in both cases. The radical surgery were conducted, and there were no lymph node metastasis and recurrence.

Byung M 2nd

1990-03-01

104

[A clinical study on the adenoid cystic carcinoma in oral cavity].  

Science.gov (United States)

Two cases of adenoid cystic carcinoma occurred on the palate are reported. They were female and aged 65 and 69 year. They showed expansile growth in association with the bony destruction of maxillary sinus wall. Histologically the case 1 had cribriform pattern and the case 2 had cribriform and tubular pattern, and exhibited perineural invasion of tumor cells in both cases. The radical surgery were conducted, and there were no lymph node metastasis and recurrence. PMID:1966821

Byung, M

1990-03-01

105

Primary cutaneous adenoid cystic carcinoma with distant metastasis: a case report and brief literature review.  

UK PubMed Central (United Kingdom)

Primary adenoid cystic carcinoma (PCACC) of skin is a rare tumor, and those who show distant metastasis are even rarer. We report a case of PCACC on the face of a 55-year-old man who showed bilateral lung metastasis and on palliative chemotherapy showed significant regression of the primary tumor. The patient was alive at a 15-month follow-up. A brief literature review of the eight cases including ours is described.

Singh A; Ramesh V

2010-03-01

106

Primary cutaneous adenoid cystic carcinoma with distant metastasis: A case report and brief literature review  

Directory of Open Access Journals (Sweden)

Full Text Available Primary adenoid cystic carcinoma (PCACC) of skin is a rare tumor, and those who show distant metastasis are even rarer. We report a case of PCACC on the face of a 55-year-old man who showed bilateral lung metastasis and on palliative chemotherapy showed significant regression of the primary tumor. The patient was alive at a 15-month follow-up. A brief literature review of the eight cases including ours is described.

Singh Avninder; Ramesh V

2010-01-01

107

Tumor-to-tumor metastasis: maxillary sinus adenoid cystic carcinoma metastasizing to double primary lung adenocarcinoma.  

Science.gov (United States)

Tumor-to-tumor metastasis is a rare occurrence. The most frequent metastatic donor is lung cancer, and the most frequent recipient is renal cell carcinoma. Here we present a patient in whom lung cancer served as a metastatic recipient and maxillary sinus adenoid cystic carcinoma acted as a metastatic donor. This patient has double primary lung cancer, which increased the complexity of this case. PMID:20868783

Lin, Wei-Yang; Hsu, Wen-Hu

2010-10-01

108

Tumor-to-tumor metastasis: maxillary sinus adenoid cystic carcinoma metastasizing to double primary lung adenocarcinoma.  

UK PubMed Central (United Kingdom)

Tumor-to-tumor metastasis is a rare occurrence. The most frequent metastatic donor is lung cancer, and the most frequent recipient is renal cell carcinoma. Here we present a patient in whom lung cancer served as a metastatic recipient and maxillary sinus adenoid cystic carcinoma acted as a metastatic donor. This patient has double primary lung cancer, which increased the complexity of this case.

Lin WY; Hsu WH

2010-10-01

109

Effect of amoxycillin with or without clavulanate on adenoid bacterial flora.  

UK PubMed Central (United Kingdom)

The effect of antimicrobial therapy with amoxycillin (AMX) or co-amoxiclav (AMC) on the adenoid bacterial flora of 45 children with recurrent otitis media (ROM), scheduled for elective adenoidectomy, was studied. Patients were randomized before surgery into three groups of 15, having had either no antibiotic therapy (control), or 10 days of therapy with AMX or AMC. Core adenoid tissues were quantitatively cultured for aerobic and anaerobic bacteria. Polymicrobial aerobic-anaerobic flora was present in all instances. The predominant aerobes in all groups were alpha-haemolytic and non-haemolytic streptococci, Haemophilus influenzae, Staphylococcus aureus, group A beta-haemolytic streptococci and Moraxella catarrhalis. The prominent anaerobes were Peptostreptococcus spp., Prevotella spp. and Fusobacterium spp. The number of isolates was significantly reduced in those treated with AMX (110; P < 0.05) or AMC (54; P < 0.001) compared with control (148). The number of bacteria per gram of tissue was lower in those treated with both antibiotics. The number of potential pathogens was lower in those treated with AMC compared with the other two groups (P < 0.001 ). The number of beta-lactamase- producing bacteria (BLPB) was lower in those treated with AMC compared with those treated with AMX (P < 0.025) or no antibiotic (P < 0.001). These data illustrate the ability of AMX and AMC to reduce the bacterial load as well as potential pathogens and BLPB from the adenoids of children with ROM.

Brook I; Shah K

2001-08-01

110

Prevalence and quantitation of adenovirus DNA from human tonsil and adenoid tissues.  

Science.gov (United States)

In this study, real-time PCR was used to quantify adenovirus DNA in cell suspensions prepared from 106 right and left tonsils and 10 adenoids obtained from 57 patients who underwent routine tonsillectomies and/or adenoidectomies. Eighty-four (72.4%) tonsils and adenoids samples were positive for HAdV by real-time PCR. The viral load ranged from 2.8?×?10(2) to 2.6?×?10(6) ?copies/10(7) cells and varied up to sixfold between the right and left tonsils. In some cases, only one tonsil was positive and the viral load was lower in older children. Seventy-eight of 84 positive samples could be typed by sequencing of the hexon L1 region. Species C (types 1, 2, and 5) were detected in 84.1% of the patients followed by types 3 and 7 of species B (6.8%), HAdV-E4 (6.8%), and HAdV-F41 (2.3%). In one patient adenovirus C2 was found in the left tonsil and adenovirus C5 in the right tonsil. No DNA methylation was detected in either the E1A promoter or the major late promoter region of adenovirus DNA from six tonsils and adenoids samples and two clinical isolates. J Med. Virol. 85:1947-1954, 2013.. © 2013 Wiley Periodicals, Inc. PMID:23852770

Alkhalaf, Moustafa Alissa; Guiver, Malcolm; Cooper, Robert J

2013-07-12

111

Prevalence and quantitation of adenovirus DNA from human tonsil and adenoid tissues.  

UK PubMed Central (United Kingdom)

In this study, real-time PCR was used to quantify adenovirus DNA in cell suspensions prepared from 106 right and left tonsils and 10 adenoids obtained from 57 patients who underwent routine tonsillectomies and/or adenoidectomies. Eighty-four (72.4%) tonsils and adenoids samples were positive for HAdV by real-time PCR. The viral load ranged from 2.8 × 10(2) to 2.6 × 10(6) copies/10(7) cells and varied up to sixfold between the right and left tonsils. In some cases, only one tonsil was positive and the viral load was lower in older children. Seventy-eight of 84 positive samples could be typed by sequencing of the hexon L1 region. Species C (types 1, 2, and 5) were detected in 84.1% of the patients followed by types 3 and 7 of species B (6.8%), HAdV-E4 (6.8%), and HAdV-F41 (2.3%). In one patient adenovirus C2 was found in the left tonsil and adenovirus C5 in the right tonsil. No DNA methylation was detected in either the E1A promoter or the major late promoter region of adenovirus DNA from six tonsils and adenoids samples and two clinical isolates.

Alkhalaf MA; Guiver M; Cooper RJ

2013-11-01

112

Nasopharyngeal Adenoid Cystic Carcinoma: Report of Five Cases and Treatment Outcome  

Directory of Open Access Journals (Sweden)

Full Text Available Background: The present study aimed to report the characteristics and treatment outcomes of five patients with nasopharyngeal adenoid cystic carcinoma and a literature review. Methods: Between 2000 and 2009, five consecutive patients (4 men, 1 woman) were diagnosed with nasopharyngeal adenoid cystic carcinoma and treated at our institution. Three patients had stage IVa (T4N0M0) and two patients had stage III (T3N0M0) cancer. Primary treatment consisted of concurrent chemoradiation in three patients andradiotherapy alone in two patients. Surgery was limited to endoscopic biopsy for histological diagnosis. Results: Four patients achieved complete response during or after completion of treatment and remained free of disease for a median of 27 months. Four patients developed local recurrence 8-30 months after initial treatment. The fifth patient is alive and free of disease.Conclusion: The findings of the present study and literature review suggest that local failure is a major problem in adenoid cystic carcinoma of the nasopharynx.

Bijan Khademi; Hajar Bahranifard; Sayed Hamed Kabiri; Samiraz Razzaghi; Seyed Basir Hashemi; Mahmood Shishegar; Mohammad Mohammadianpanah

2011-01-01

113

Searching the H. pylori; serology & PCR in children with adenoid hypertrophy and rhino sinusitis: a cross sectional study, Tehran, Iran.  

UK PubMed Central (United Kingdom)

OBJECTIVE: Searching the H. pylori -DNAs in adenoid and IgA, IgG antibodies in serum of children. METHODS: A cross- sectional study had done upon 53 children (Mean age 8 ±1.9 years) with adenoid surgery in ENT and Pediatric Department of Rasul Akram Hospital (2008-2010). Of 53 cases with adenoid surgery, 40 cases had rhino sinusitis (in sinus CT scan). The resected adenoid tissues (n=40) centrifuged and homogenized and its DNAs extracted and searched for H. pylori- DNAs by qualitative PCR. Serum H. pylori antibodies (IgG &IgA ELISA) calculated quantitatively. Chi square values (p < 0.05) calculated for all categorical variables. The agreement between serologic test and PCR was assessed by the calculation of kappa statistic. RESULTS: Positive PCR for H. pylori detected in 15%of cases; regardless of sex and age of cases. Positive IgA: 17.5% (7/40) and IgG: 20% (8/40) respectively. All cases with positive H. pylori- IgG were female; p=0.003 and meaningful differences in mean age of cases observed for positive IgA (p=0.001) and IgG (p=0.01). Poor agreement observed between positive PCR and serum IgG&IgA (Fisher's Exact test=0.3; 0.5). CONCLUSION: Positive PCR in adenoid tissue (15%) was very close to positive serum IgA (15%) but without any agreement for each case. The H. pylori infection may have a relative role at least in 15% of children with adenoid surgery. Chronic sinusitis and ear infection might be added to infected adenoid tissue as a reservoir for bacteria. The search by specific culture may elucidate better the role of H. pylori infections in both gastric and adenoid tissues. The decision for use of antibiotics to eradicate the H. pylori infection in recurrent or chronic adenotonsillar infections (with rhinosinusitis) before adenoid surgery needs Randomized Control Trial (RCT) studies. Drug of choice for eradication of H. pylori dependent to antibiotic sensitivity test in each country.

Farhadi M; Noorbakhsh S; Tabatabaei A

2013-05-01

114

Effect of antimicrobial therapy with amoxicillin and cefprozil on bacterial interference and beta-lactamase production in the adenoids.  

UK PubMed Central (United Kingdom)

To compare the effects on the bacterial flora of the adenoids of antimicrobial therapy with amoxicillin or cefprozil, we enrolled in a prospective randomized study 60 children scheduled for elective adenoidectomy because of recurrent otitis media. They were randomized before surgery into 3 groups of 20 patients each: a no-therapy group, and groups with 10 days of either amoxicillin or cefprozil therapy. Core adenoid materials were quantitatively cultured for aerobic and facultative bacteria. The in vitro ability of alpha-hemolytic streptococci (AHS) to inhibit the growth of non-type B Haemophilus influenzae and Streptococcus pneumoniae was determined. The number of organisms in adenoids obtained from patients treated with either antibiotic was reduced as compared to that in adenoids from controls. However, in patients treated with amoxicillin, a significant decline in the number of AHS, and an increase (in Staphylococcus aureus) or no change in the number of other beta-lactamase-producing bacteria (BLPB) was noted. In contrast, in those treated with cefprozil, no change was noted in the frequency of recovery of AHS, and the number of BLPB decreased. Interfering AHS were more often recovered in patients treated with cefprozil. We conclude that the adenoids contain more interfering AHS after therapy with a second-generation oral cephalosporin (cefprozil) than after amoxicillin therapy. This study suggests a potential beneficial effect of using an antimicrobial that selectively spares interfering AHS while inhibiting BLPB.

Brook I; Foote PA Jr

2004-11-01

115

Effect of antimicrobial therapy with amoxicillin and cefprozil on bacterial interference and beta-lactamase production in the adenoids.  

Science.gov (United States)

To compare the effects on the bacterial flora of the adenoids of antimicrobial therapy with amoxicillin or cefprozil, we enrolled in a prospective randomized study 60 children scheduled for elective adenoidectomy because of recurrent otitis media. They were randomized before surgery into 3 groups of 20 patients each: a no-therapy group, and groups with 10 days of either amoxicillin or cefprozil therapy. Core adenoid materials were quantitatively cultured for aerobic and facultative bacteria. The in vitro ability of alpha-hemolytic streptococci (AHS) to inhibit the growth of non-type B Haemophilus influenzae and Streptococcus pneumoniae was determined. The number of organisms in adenoids obtained from patients treated with either antibiotic was reduced as compared to that in adenoids from controls. However, in patients treated with amoxicillin, a significant decline in the number of AHS, and an increase (in Staphylococcus aureus) or no change in the number of other beta-lactamase-producing bacteria (BLPB) was noted. In contrast, in those treated with cefprozil, no change was noted in the frequency of recovery of AHS, and the number of BLPB decreased. Interfering AHS were more often recovered in patients treated with cefprozil. We conclude that the adenoids contain more interfering AHS after therapy with a second-generation oral cephalosporin (cefprozil) than after amoxicillin therapy. This study suggests a potential beneficial effect of using an antimicrobial that selectively spares interfering AHS while inhibiting BLPB. PMID:15562900

Brook, Itzhak; Foote, Perry A

2004-11-01

116

Adenoid cystic carcinomas of the breast have low Topo II? expression but frequently overexpress EGFR protein without EGFR gene amplification.  

UK PubMed Central (United Kingdom)

Adenoid cystic carcinoma of the breast is a rare subtype of breast cancer with basal-like features. Published studies on breast adenoid cystic carcinoma are limited, resulting in relatively scarce information on the value of predictive tumor markers. We studied 20 primary cases of adenoid cystic carcinoma of the breast for expression of estrogen receptor, progesterone receptor, androgen receptor, epidermal growth factor receptor, HER-2/neu, and topoisomerase II? using immunohistochemistry and fluorescent in situ hybridization methods. Estrogen and progesterone receptor expression were detected in 1 case each. All tumors were uniformly negative for Her-2/neu expression. Androgen receptor and topoisomerase II? expression were weakly positive in three cases and 7 cases, respectively. Epidermal growth factor receptor overexpression was detected in 13 cases (65% of all cases). Amplification of TOP2A or HER-2/neu gene was not detected in any of the cases. Our study shows that the majority of adenoid cystic carcinomas of the breast do not overexpress Her-2/neu, topoisomerase II?, or estrogen receptor, and thus, they are unlikely to respond to therapies targeting these proteins. However, these tumors frequently over-express epidermal growth factor receptor, indicating a potential benefit from anti-epidermal growth factor receptor therapy for patients with advanced adenoid cystic carcinomas of the breast.

Vranic S; Frkovic-Grazio S; Lamovec J; Serdarevic F; Gurjeva O; Palazzo J; Bilalovic N; Lee LM; Gatalica Z

2010-11-01

117

Adenoid cystic carcinomas of the breast have low Topo II? expression but frequently overexpress EGFR protein without EGFR gene amplification.  

Science.gov (United States)

Adenoid cystic carcinoma of the breast is a rare subtype of breast cancer with basal-like features. Published studies on breast adenoid cystic carcinoma are limited, resulting in relatively scarce information on the value of predictive tumor markers. We studied 20 primary cases of adenoid cystic carcinoma of the breast for expression of estrogen receptor, progesterone receptor, androgen receptor, epidermal growth factor receptor, HER-2/neu, and topoisomerase II? using immunohistochemistry and fluorescent in situ hybridization methods. Estrogen and progesterone receptor expression were detected in 1 case each. All tumors were uniformly negative for Her-2/neu expression. Androgen receptor and topoisomerase II? expression were weakly positive in three cases and 7 cases, respectively. Epidermal growth factor receptor overexpression was detected in 13 cases (65% of all cases). Amplification of TOP2A or HER-2/neu gene was not detected in any of the cases. Our study shows that the majority of adenoid cystic carcinomas of the breast do not overexpress Her-2/neu, topoisomerase II?, or estrogen receptor, and thus, they are unlikely to respond to therapies targeting these proteins. However, these tumors frequently over-express epidermal growth factor receptor, indicating a potential benefit from anti-epidermal growth factor receptor therapy for patients with advanced adenoid cystic carcinomas of the breast. PMID:20688355

Vranic, Semir; Frkovic-Grazio, Snjezana; Lamovec, Janez; Serdarevic, Fadila; Gurjeva, Olga; Palazzo, Juan; Bilalovic, Nurija; Lee, Lisa M J; Gatalica, Zoran

2010-08-04

118

A phase II study of Imatinib for advanced adenoid cystic carcinoma of head and neck salivary glands.  

UK PubMed Central (United Kingdom)

Adenoid cystic carcinoma of the salivary glands is characterized by a poor response to chemotherapy. Most cases of adenoid cystic carcinoma express the c-kit protein. Imatinib mesylate (Gleevec) inhibits several protein-tyrosine kinases, including c-kit. We therefore hypothesized that Imatinib may be an effective drug in patients with locally advanced or metastatic adenoid cystic carcinoma and conducted a phase 2 trial in order to study this. Patients with locally advanced or metastatic adenoid cystic carcinoma and c-kit positive tumours were eligible. Fourteen patients were screened and 10 patients (71%) with c-kit positive tumours entered the study. Treatment was begun at a dose of Imatinib of 400mg/day. Dose escalation was allowed in the absence of toxicity. The dose was increased to 600mg/d in three patients and 800mg/d in one patient. Three patients required dose reduction to 300mg/d, due to grade 3 toxicity. No grade 4 toxicity was seen. No objective responses were seen. Two patients (20%) exhibited stable disease for 11 and 14 months, respectively. All other patients stopped treatment after 2-14 (median 6) months due to progressive disease. Imatinib has no major effect on advanced adenoid cystic carcinoma of the head and neck.

Pfeffer MR; Talmi Y; Catane R; Symon Z; Yosepovitch A; Levitt M

2007-01-01

119

A phase II study of Imatinib for advanced adenoid cystic carcinoma of head and neck salivary glands.  

Science.gov (United States)

Adenoid cystic carcinoma of the salivary glands is characterized by a poor response to chemotherapy. Most cases of adenoid cystic carcinoma express the c-kit protein. Imatinib mesylate (Gleevec) inhibits several protein-tyrosine kinases, including c-kit. We therefore hypothesized that Imatinib may be an effective drug in patients with locally advanced or metastatic adenoid cystic carcinoma and conducted a phase 2 trial in order to study this. Patients with locally advanced or metastatic adenoid cystic carcinoma and c-kit positive tumours were eligible. Fourteen patients were screened and 10 patients (71%) with c-kit positive tumours entered the study. Treatment was begun at a dose of Imatinib of 400mg/day. Dose escalation was allowed in the absence of toxicity. The dose was increased to 600mg/d in three patients and 800mg/d in one patient. Three patients required dose reduction to 300mg/d, due to grade 3 toxicity. No grade 4 toxicity was seen. No objective responses were seen. Two patients (20%) exhibited stable disease for 11 and 14 months, respectively. All other patients stopped treatment after 2-14 (median 6) months due to progressive disease. Imatinib has no major effect on advanced adenoid cystic carcinoma of the head and neck. PMID:16757202

Pfeffer, M Raphael; Talmi, Yoav; Catane, Raphael; Symon, Zvi; Yosepovitch, Ady; Levitt, Mark

2006-06-06

120

[Tracheal adenoid cystic carcinoma treated by complete carinal reconstruction with the help of an ECMO: about a case].  

Science.gov (United States)

Primitive tumors of the trachea are rare, accounting for 0.1% of the airway tumors. Cystic adenoid carcinoma (or cylindroma) represents the second most frequent type of tracheal cancers. Histologically speaking, this tumor type is divided in three patterns: cribriform, tubular and solid; it presents a slow growth, perineural invasion and potential local recurrence and metastasis. We presented herein the case of a 56-year-old female suffering from a cystic adenoid carcinoma of the low trachea. She has been treated by carinal resection with negative airway margin and complete reconstruction, with the help of an extra corporeal membrane oxygenation (ECMO). PMID:23597633

Rouzé, S; Flécher, E; de Latour, B; Meunier, C; Sellin, M; Lena, H; Verhoye, J-P

2013-04-15

 
 
 
 
121

Surgical management of locally advanced adenoid cystic carcinoma of the lacrimal gland.  

UK PubMed Central (United Kingdom)

PURPOSE: To review our experience with multidisciplinary surgical management of locally advanced adenoid cystic carcinoma of the lacrimal gland. METHODS: We present a case series of 7 patients with lacrimal gland adenoid cystic carcinoma treated at our institution between June 2001 and October 2003. Clinical records, histologic sections, and radiographic images were reviewed. RESULTS: The study included 3 men and 4 women (mean age at diagnosis, 44 years). All 7 patients underwent an orbital exenteration with bone removal. Five patients had an orbitectomy through a craniotomy approach and 2 patients had an exenteration through a fronto-orbito-zygomatic approach, all with removal of the bone of the superior and lateral wall. Six patients underwent reconstruction of the socket through the use of a vascularized flap. The surgical approach involved a neurosurgeon, an oculoplastic or head and neck surgeon, and a plastic surgeon. Six patients received postoperative radiation therapy. One patient with a recurrent tumor had already received radiation therapy, which precluded additional radiation therapy after surgical resection. The radiation field included the orbit and the skull base because all patients had evidence of perineural invasion. As of this writing, there have been no local recurrences. Five patients had development of distant metastases and died of disease, at follow-up times from 12 to 32 months after surgery. Two patients are alive without evidence of disease, both at 24 months' follow-up. CONCLUSIONS: Orbitectomy with bone removal may be indicated for achieving local and regional control in advanced cases of adenoid cystic carcinoma of the lacrimal gland. This surgery does not decrease the risk of distant metastasis. The cases in our series highlight the locally invasive and metastatic behavior of this cancer.

Esmaeli B; Golio D; Kies M; DeMonte F

2006-09-01

122

Two cases of severe tracheal stenosis due to advanced adenoid cystic carcinoma of the trachea  

Energy Technology Data Exchange (ETDEWEB)

Two cases of severe tracheal stenosis due to advanced nonresectable adenoid cystic carcinoma of the trachea were reported. Case 1 was a 38-year-old male who underwent emergency {sup 60}Co irradiation following endoscopic YAG laser irradiation. This approach was quite effective. Proton irradiation was effective against tumor recurrence. Case 2 was a 28-year-old female in whom emergency treatment for tracheal obstruction due to edema after laser therapy necessitated transient tracheal intubation. The tracheal stenosis due to recurrent tumor after {sup 60}Co irradiation was improved by insertion of an intraluminal permanent stent. (author).

Yuasa, Hiroshi; Akaogi, Eiichi; Morita, Riichiro; Onizuka, Masataka; Mitsui, Kiyofumi (Tsukuba Univ., Ibaraki (Japan). Inst. of Clinical Medicine); Tsuji, Hirohiko

1991-12-01

123

Two cases of severe tracheal stenosis due to advanced adenoid cystic carcinoma of the trachea  

International Nuclear Information System (INIS)

[en] Two cases of severe tracheal stenosis due to advanced nonresectable adenoid cystic carcinoma of the trachea were reported. Case 1 was a 38-year-old male who underwent emergency 60Co irradiation following endoscopic YAG laser irradiation. This approach was quite effective. Proton irradiation was effective against tumor recurrence. Case 2 was a 28-year-old female in whom emergency treatment for tracheal obstruction due to edema after laser therapy necessitated transient tracheal intubation. The tracheal stenosis due to recurrent tumor after 60Co irradiation was improved by insertion of an intraluminal permanent stent. (author)

1991-01-01

124

Cultivo primario de células ciliadas de adenoides humanos: Un modelo experimental para evaluar la actividad ciliar in vitro Primary culture of human adenoid ciliated cells: An experimental model to evaluate ciliar activity in vitro  

Directory of Open Access Journals (Sweden)

Full Text Available Introducción: El clearance mucociliar normal es el mecanismo de defensa básico de las vías respiratorias. Sin embargo, los mecanismos de control ciliar aún se desconocen. Con el fin de entenderlo mejor, se han desarrollado diferentes técnicas de cultivo de células ciliadas. Objetivos: Desarrollar un modelo experimental a partir de cultivos primarios de tejido adenoideo y cornete medio. Caracterizarla respuesta a adenosin trifosfato (ATP), agonista conocido de la frecuencia de batido ciliar (FBC). Material y método: Cultivos primarios a partir de explantes de epitelio adenoideo y cornete medio humano. Medición de FBC, con técnica de microfotodensitometría, en condición basal y en respuesta a ATP a diferentes concentraciones. Resultados: La FBC basal (promedio (X) ±desv estándar (DE)) para los cultivos de cornete medio fue 11,9 ±1,5 Hz y para tejido adenoideo fue 10,9 ±1,9 (p >0,05). Se observó un aumento en la FBC en respuesta a ATP, dosis dependiente. No hubo diferencia significativa en la FBC basal ni en la respuesta a ATP entre cultivos de cornete medio y adenoides. Conclusión: El cultivo primario de células ciliadas nasales a partir de explantes de adenoides, es un modelo experimental reproducible, en el que es posible observar actividad ciliary una respuesta funcional concordante con lo descrito en la literaturaIntroduction. Mucociliary clearance constitutes the main defense mechanism of the airway, but the mechanisms of ciliary control are still unknown. With the aim of a better understanding of this process, many ciliated cells culture techniques have been developed. Aims. 1. To develop an experimental model based on primary cultures from adenoid and middle turbinate tissue. 2. To characterize in this model the response to ATP, a known agonist of ciliary beat frequency (CBF). Material and Method. Primary cultures derived from human adenoid tissue and middle turbinate epithelial explants were obtained. CFB was measured by microphotodensitometry, both in basal conditions and in response to ATP at different concentrations. Results. Basal CFB (average (X) +- standard deviation (SD)) for middle turbinate cultures was 11.9 +-1.5 Hz, and for adenoid tissue was 10.9 +-1.9 Hz (p< 0.05). A CBF increase was observed in response to ATP, in a dose-dependent manner. No significant difference in basal CFB or in response to ATP was found between middle turbinate and adenoid cultures. Conclusion. Primary culture of nasal ciliated cells derived from adenoid explants is a reproducible experimental model, in which it is possible to observe both ciliary activity and a functional response in accordance to what has been reported in the literature

Claudia González; Trinidad Sánchez; Ximena Fonseca; Manuel Villalón

2007-01-01

125

Epithelial cell culture from human adenoids: a functional study model for ciliated and secretory cells.  

UK PubMed Central (United Kingdom)

BACKGROUND: Mucociliary transport (MCT) is a defense mechanism of the airway. To study the underlying mechanisms of MCT, we have both developed an experimental model of cultures, from human adenoid tissue of ciliated and secretory cells, and characterized the response to local chemical signals that control ciliary activity and the secretion of respiratory mucins in vitro. MaterIALS AND METHODS: In ciliated cell cultures, ciliary beat frequency (CBF) and intracellular Ca(2+) levels were measured in response to ATP, UTP, and adenosine. In secretory cultures, mucin synthesis and secretion were identified by using immunodetection. Mucin content was taken from conditioned medium and analyzed in the presence or absence of UTP. RESULTS: Enriched ciliated cell monolayers and secretory cells were obtained. Ciliated cells showed a basal CBF of 10.7 Hz that increased significantly after exposure to ATP, UTP, or adenosine. Mature secretory cells showed active secretion of granules containing different glycoproteins, including MUC5AC. CONCLUSION: Culture of ciliated and secretory cells grown from adenoid epithelium is a reproducible and feasible experimental model, in which it is possible to observe ciliary and secretory activities, with a potential use as a model to understand mucociliary transport control mechanisms.

González C; Espinosa M; Sánchez MT; Droguett K; Ríos M; Fonseca X; Villalón M

2013-01-01

126

Lacrimal gland adenoid cystic carcinoma: intracranial and extracranial en bloc resection.  

UK PubMed Central (United Kingdom)

Adenoid cystic carcinoma of the lacrimal gland is a rare tumor, although it is the malignancy most frequently arising in the gland. Treatment has been unsuccessful generally, with a 15-year survival of less than 20 percent. Our experience with this tumor in a 61-year-old woman has led to a proposal for therapeutic management based on awareness of the lesion's natural history, an understanding of regional anatomy, and familiarity with therapies reported in the literature. The feasibility of adequate tumor ablation is determined from preoperative evaluation, including CT scan, initial exploratory craniotomy, and frozen-section examination of the cranial nerves transversing the orbit. Once resectability is confirmed, "curative" intracranial and extracranial en bloc resection is performed, including the tumor, the lacrimal gland, and all contiguous structures. The defect is immediately resurfaced with and "ice cream cone" forehead flap in anticipation of adjuvant radiotherapy. An orbital prosthesis is fitted as soon as the radiation reaction subsides, and a postablative CT scan is obtained as the baseline for follow-up. It remains to be seen whether this application of the technology of CT scanning and the techniques of craniofacial surgery will improve the prognosis for adenoid cystic carcinoma arising in the lacrimal gland.

Marsh JL; Wise DM; Smith M; Schwartz H

1981-10-01

127

Lacrimal gland adenoid cystic carcinoma: intracranial and extracranial en bloc resection.  

Science.gov (United States)

Adenoid cystic carcinoma of the lacrimal gland is a rare tumor, although it is the malignancy most frequently arising in the gland. Treatment has been unsuccessful generally, with a 15-year survival of less than 20 percent. Our experience with this tumor in a 61-year-old woman has led to a proposal for therapeutic management based on awareness of the lesion's natural history, an understanding of regional anatomy, and familiarity with therapies reported in the literature. The feasibility of adequate tumor ablation is determined from preoperative evaluation, including CT scan, initial exploratory craniotomy, and frozen-section examination of the cranial nerves transversing the orbit. Once resectability is confirmed, "curative" intracranial and extracranial en bloc resection is performed, including the tumor, the lacrimal gland, and all contiguous structures. The defect is immediately resurfaced with and "ice cream cone" forehead flap in anticipation of adjuvant radiotherapy. An orbital prosthesis is fitted as soon as the radiation reaction subsides, and a postablative CT scan is obtained as the baseline for follow-up. It remains to be seen whether this application of the technology of CT scanning and the techniques of craniofacial surgery will improve the prognosis for adenoid cystic carcinoma arising in the lacrimal gland. PMID:6269133

Marsh, J L; Wise, D M; Smith, M; Schwartz, H

1981-10-01

128

Dysphagia due to adenoid cystic carcinoma of the base of the tongue.  

UK PubMed Central (United Kingdom)

OBJECTIVES: Although oropharyngeal neoplasia can often lead to dysphagia, salivary gland tumors rarely grow within the tongue base. We present the case of a 75-year-old man with adenoid cystic carcinoma of the base of the tongue causing profound dysphagia and weight loss, and provide a current literature review and update on the management of these rare tumors. METHODS: We present a case report and a literature review. RESULTS: Physical examination performed at the initial visit revealed a firm right base-of-tongue mass with no palpable lymphadenopathy. Flexible fiberoptic laryngoscopy confirmed a large submucosal mass at the right base of the tongue that obscured the right vallecula. Histopathologic analysis of the operative biopsy specimens revealed the classic features of adenoid cystic carcinoma. Treatment included radical pharyngotomy with wide local excision and primary closure, followed by postoperative radiation treatment. CONCLUSIONS: We demonstrate the clinical examination findings and histopathologic characteristics of this disease, and review the literature for clinical treatment recommendations for this rare cause of dysphagia.

Hoekzema CR; Massey BL; Blumin JH; Hunt BC; Bock JM

2012-06-01

129

Adenoid cystic carcinoma of the parotid gland: Anastamosis of the facial nerve with the great auricular nerve after radical parotidectomy  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Adenoid cystic carcinoma of the parotid gland is a rare and slowly growing, but highly malignant tumor. Surgical resection of a malignant parotid tumor should include resection of the facial nerve when the nerve is involved in the tumor. Facial nerve reconstruction is required after nerve resection....

Bahadir Osman; Livaoglu Murat; Ural Ahmet

130

Multiple Malignant Salivary Gland Neoplasms: Mucoepidermoid Carcinoma of Palate and Adenoid Cystic Carcinoma of Floor of Mouth  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Salivary gland tumors usually occur as single lesions. To have more than one tumor is unusual. We report a case of an adult male who presented with a mucoepidermoid carcinoma involving the minor salivary glands of the palate at age 57 years, followed by an adenoid cystic carcinoma of the floor of mo...

Whitt, Joseph C.; Schafer, Duane R.; Callihan, Michael D.

131

Increased numbers of P63-positive/CD117-positive cells in advanced adenoid cystic carcinoma give a poorer prognosis  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Abstract Objectives This study consisted of two parts. One part was to analyze the survival rates of adenoid cystic carcinoma (ACC) in Chinese and explain the difference between our data and the literature. The other was to analyze the relationship between the expression of CD117 an...

Zhou Quan; Chang Hong; Zhang Hongkai; Han Yiding; Liu Honggang

132

Synchronous metastatic adenoid cystic and squamous cell carcinoma of the cervical lymph nodes 31 years after ablation of the primary palatal tumour.  

Science.gov (United States)

The coexistence of different types of malignancy in cervical lymph nodes has been reported previously. We report the first case, to the best of our knowledge, of concurrent metastatic adenoid cystic carcinoma and squamous cell carcinoma (SCC) in cervical lymph nodes. A primary SCC developed three decades after treatment for adenoid cystic carcinoma of the palate, and the synchronous metastases became clinically apparent the following year. The aetiology of the SCC may have been related to radiotherapy or smoking. Whether the adenoid cystic carcinoma would have remained dormant, or was reactivated after perturbation of host defence mechanisms, is not known. PMID:22858404

Doumas, Stergios; Barrett, Andrew W; Carrillo, Mauricio; Tighe, John V

2012-08-02

133

Radiotherapy for advanced adenoid cystic carcinoma: neutrons, photons or mixed beam?  

UK PubMed Central (United Kingdom)

PURPOSE: To compare retrospectively radiotherapy with neutrons, photons, and a photon/neutron mixed beam in patients with advanced adenoid cystic carcinoma of the head and neck. Local control, survival, distant failure, and complications were analyzed. MATERIALS AND METHODS: Between 1983 and 1995, 75 patients with inoperable, recurrent, or incompletely resected adenoid cystic carcinoma of the head and neck received radiotherapy that consisted of either fast 14.1 MV DT neutrons (median dose 16 neutron Gy), linac-based photon irradiation (median dose 64 photon Gy), or both (median dose 8 neutron Gy and 32 photon Gy). Follow-up ranged from 1 to 160 months (median 51 months), and the surviving patients had a minimum follow-up of 3 years at the time of analysis. RESULTS: The actuarial 5-year local control was 75% for neutrons, and 32% for both mixed beam and photons (P = 0.015, log-rank). This advantage for neutrons in local control was not transferred to significant differences in survival (P > 0.1). The survival is dictated by the tumor diseases due to distant metastases occurring in 29 (39%) of the 75 patients. Positive lymph nodes were the only significant factor (P = 0.001) associated with the development of distant metastases although negative lymph nodes did not predict absence of distant metastases, but predicted a delay of occurrence. In multivariate analysis postoperative radiotherapy (P = 0.003) and small tumor size (P = 0.01) were associated with high local control, while primary therapy (P = 0.006) and negative lymph nodes (P = 0.01) were associated with longer survival. While acute toxicity was similar in all three radiotherapy groups, severe late grade 3 and 4 toxicity tended to be more prevalent (P > 0.1) with neutrons (19%) than with mixed beam (10%) and photons (4%). CONCLUSION: Fast neutron radiotherapy provides higher local control rates than a mixed beam and photons in advanced, recurrent or not completely resected adenoid cystic carcinoma of the major and minor salivary glands. Neutron radiotherapy can be recommended in patients with bad prognosis with gross residual disease (R2), with unresectable tumors, or inoperable tumors. The type of radiation does not impact survival, which is dominated by the high number of distant metastases.

Huber PE; Debus J; Latz D; Zierhut D; Bischof M; Wannenmacher M; Engenhart-Cabillic R

2001-05-01

134

Radiotherapy for advanced adenoid cystic carcinoma: neutrons, photons or mixed beam?  

International Nuclear Information System (INIS)

[en] Purpose: To compare retrospectively radiotherapy with neutrons, photons, and a photon/neutron mixed beam in patients with advanced adenoid cystic carcinoma of the head and neck. Local control, survival, distant failure, and complications were analyzed. Materials and methods: Between 1983 and 1995, 75 patients with inoperable, recurrent, or incompletely resected adenoid cystic carcinoma of the head and neck received radiotherapy that consisted of either fast 14.1 MV DT neutrons (median dose 16 neutron Gy), linac-based photon irradiation (median dose 64 photon Gy), or both (median dose 8 neutron Gy and 32 photon Gy). Follow-up ranged from 1 to 160 months (median 51 months), and the surviving patients had a minimum follow-up of 3 years at the time of analysis. Results: The actuarial 5-year local control was 75% for neutrons, and 32% for both mixed beam and photons (P=0.015, log-rank). This advantage for neutrons in local control was not transferred to significant differences in survival (P>0.1). The survival is dictated by the tumor diseases due to distant metastases occurring in 29 (39%) of the 75 patients. Positive lymph nodes were the only significant factor (P=0.001) associated with the development of distant metastases although negative lymph nodes did not predict absence of distant metastases, but predicted a delay of occurrence. In multivariate analysis postoperative radiotherapy (P=0.003) and small tumor size (P=0.01) were associated with high local control, while primary therapy (P=0.006) and negative lymph nodes (P=0.01) were associated with longer survival. While acute toxicity was similar in all three radiotherapy groups, severe late grade 3 and 4 toxicity tended to be more prevalent (P>0.1) with neutrons (19%) than with mixed beam (10%) and photons (4%). Conclusion: Fast neutron radiotherapy provides higher local control rates than a mixed beam and photons in advanced, recurrent or not completely resected adenoid cystic carcinoma of the major and minor salivary glands. Neutron radiotherapy can be recommended in patients with bad prognosis with gross residual disease (R2), with unresectable tumors, or inoperable tumors. The type of radiation does not impact survival, which is dominated by the high number of distant metastases

2001-05-01

135

PLAG1 and CYLD do not play a role in the tumorigenesis of adenoid cystic carcinoma.  

UK PubMed Central (United Kingdom)

The pleiomorphic adenoma gene 1 (PLAG1) gene is activated in a subset of pleomorphic adenomas of the salivary gland by gene fusion. Germ?line mutation in cylindromatosis (CYLD), a tumor suppressor gene, causes familial cylindromatosis and Brook?Spiegler syndrome. In the present study, aberrations in PLAG1 and CYLD were investigated in adenoid cystic carcinoma (ACC) of the salivary gland. Reverse?transcription PCR and PCR direct sequencing were performed to detect gene fusion of PLAG1 and mutation of CYLD in 34 ACC tissues. No PLAG1 fusion was detected in ACC. However, silent mutation of CYLD was detected in 2 cases of ACC, but no missense mutation was detected in ACC. These results suggest that PLAG1 and CYLD do not play a role in ACC tumorigenesis.

Daa T; Nakamura I; Yada N; Arakane S; Nishida H; Kashima K; Suzuki M; Yokoyama S

2013-04-01

136

Mutation signature of adenoid cystic carcinoma: evidence for transcriptional and epigenetic reprogramming.  

Science.gov (United States)

Adenoid cystic carcinoma (ACC), a relatively rare malignancy usually of salivary gland origin, has a signature v-myb avian myeloblastosis viral oncogene homolog-nuclear factor I/B (MYB-NFIB) gene fusion that activates MYB transcriptional regulatory activity. A new study in this issue by Stephens et al. is a comprehensive genomic mutation profiling analysis of this neoplasm and documents a common theme of alteration in chromatin regulatory genes. Also, mutations in SPEN (split ends, homolog of Drosophila), which encodes an RNA-binding coregulatory protein, suggest that other changes in transcriptional regulation may involve the NOTCH, FGFR, or other signaling pathways in which SPEN participates. Since there is a low prevalence of mutations in common oncogenes and tumor-suppressor genes, it is likely that alterations primarily in specific transcriptional regulatory genes, augmented by changes in chromatin structure, drive the neoplastic process in ACC. PMID:23778135

Frierson, Henry F; Moskaluk, Christopher A

2013-06-17

137

Mutation signature of adenoid cystic carcinoma: evidence for transcriptional and epigenetic reprogramming.  

UK PubMed Central (United Kingdom)

Adenoid cystic carcinoma (ACC), a relatively rare malignancy usually of salivary gland origin, has a signature v-myb avian myeloblastosis viral oncogene homolog-nuclear factor I/B (MYB-NFIB) gene fusion that activates MYB transcriptional regulatory activity. A new study in this issue by Stephens et al. is a comprehensive genomic mutation profiling analysis of this neoplasm and documents a common theme of alteration in chromatin regulatory genes. Also, mutations in SPEN (split ends, homolog of Drosophila), which encodes an RNA-binding coregulatory protein, suggest that other changes in transcriptional regulation may involve the NOTCH, FGFR, or other signaling pathways in which SPEN participates. Since there is a low prevalence of mutations in common oncogenes and tumor-suppressor genes, it is likely that alterations primarily in specific transcriptional regulatory genes, augmented by changes in chromatin structure, drive the neoplastic process in ACC.

Frierson HF Jr; Moskaluk CA

2013-07-01

138

Identification of acid-sensing ion channels in adenoid cystic carcinomas  

International Nuclear Information System (INIS)

Tissue acidosis is an important feature of tumor. The response of adenoid cystic carcinoma (ACC) cells to acidic solution was studied using whole-cell patch-clamp recording in the current study. An inward, amiloride-sensitive Na+ current was identified in cultured ACC-2 cells while not in normal human salivary gland epithelial cells. Electrophysiological and pharmacological properties of the currents suggest that heteromeric acid-sensing ion channels (ASICs) containing 2a and 3 may be responsible for the proton-induced currents in the majority of ACC-2 cells. Consistent with it, analyses of RT-PCR and Western blotting demonstrated the presences of ASIC2a and 3 in ACC-2 cells. Furthermore, we observed the enhanced expression of ASIC2a and 3 in the sample of ACC tissues. These results indicate that the functional expression of ASICs is characteristic feature of ACC cells.

2007-04-20

139

Adenoid cystic carcinoma of Bartholin's gland: what is the optimal approach?  

UK PubMed Central (United Kingdom)

AIMS AND METHODS: We report the case of a locally advanced adenoid cystic carcinoma of Bartholin's gland which required posterior pelvic exenteration, radical vulvectomy and ablation of the ischiorectal fossa in order to obtain tumour clearance with negative margins. Including this case, only three pelvectomies have been performed for this disease. This is the first reported case in which a controlateral unsuspected intravulvar metastasis was found on histology. RESULTS AND CONCLUSIONS: No consensus exists on the adequate surgical management of this particular disease. Nevertheless, a review of the literature and this reported case suggest that radical vulvectomy with negative margins should be preferred to wide local excision as the primary surgical procedure. It also suggests that inguinofemoral lymph-node dissection should only be performed when suspect lymph nodes are found at clinical examination.

Anaf V; Buxant F; Rodesch F; Simon P; van de Stadt J; Noel JC; van Geertruyden J

1999-08-01

140

Severe Ectopic Cushing Syndrome Caused by Adenoid Cystic Carcinoma of a Salivary Gland.  

UK PubMed Central (United Kingdom)

Objective: We present a rare case of Cushing syndrome due to ectopic ACTH secretion (EAS). To our knowledge only two similar cases have been previously reported.Methods: This is a case report of EAS by a Metastatic Lingual Adenoid Cystic Carcinoma (ACC).Results: The patient was diagnosed of a Cushing Syndrome caused by tumoral EAS, two years after initial cancer diagnosis. Clinical presentation included asthenia, insomnia, hypertension, acne and hyperpigmentation developing in a period of two months. Laboratory and imaging testing revealed hypokalemic metabolic alkalosis, hipercortisolemia, high ACTH, non-suppresion by 8 mg dexamethasone, and a normal pituitary magnetic resonance scan. With a high clinical suspicion of EAS, combined medical treatment was started but was unsuccessful and bilateral adrenalectomy could not be performed given the patient's rapid deterioration. Tissue from the original tumor showed positive immunostaining for synaptophysin.Conclusion: This rare case of EAS illustrates the challenge that this condition may confer regarding diagnosis and management.

Alcantara VA; Urgell E; Sancho JF; Chico A

2013-06-01

 
 
 
 
141

Severe Ectopic Cushing Syndrome Caused by Adenoid Cystic Carcinoma of a Salivary Gland.  

Science.gov (United States)

Objective: We present a rare case of Cushing syndrome due to ectopic ACTH secretion (EAS). To our knowledge only two similar cases have been previously reported.Methods: This is a case report of EAS by a Metastatic Lingual Adenoid Cystic Carcinoma (ACC).Results: The patient was diagnosed of a Cushing Syndrome caused by tumoral EAS, two years after initial cancer diagnosis. Clinical presentation included asthenia, insomnia, hypertension, acne and hyperpigmentation developing in a period of two months. Laboratory and imaging testing revealed hypokalemic metabolic alkalosis, hipercortisolemia, high ACTH, non-suppresion by 8 mg dexamethasone, and a normal pituitary magnetic resonance scan. With a high clinical suspicion of EAS, combined medical treatment was started but was unsuccessful and bilateral adrenalectomy could not be performed given the patient's rapid deterioration. Tissue from the original tumor showed positive immunostaining for synaptophysin.Conclusion: This rare case of EAS illustrates the challenge that this condition may confer regarding diagnosis and management. PMID:23757606

Alcantara, Valeria A; Urgell, Eulalia; Sancho, J Francesc; Chico, Ana

2013-06-11

142

Treatment of locally advanced adenoid cystic carcinoma of the head and neck with neutron radiotherapy  

International Nuclear Information System (INIS)

Purpose: To examine the efficacy of fast neutron radiotherapy for the treatment of locally advanced and/or recurrent adenoid cystic carcinoma of the head and neck and to identify prognostic variables associated with local-regional control and survival. Methods and Materials: One hundred fifty-nine patients with nonmetastatic, previously unirradiated, locally advanced, and/or recurrent adenoid cystic carcinoma (ACC) of the head and neck region were treated with fast neutron radiotherapy during the years 1985-1997. One hundred fifty-one patients had either unresectable disease, or gross residual disease (GRD) after an attempted surgical extirpation. Eight patients had microscopic residual disease and were analyzed separately. Sixty-two percent of patients had tumors arising in minor salivary glands, 29% in major salivary glands, and 9% in other sites such as the lacrimal glands, tracheal-bronchial tree, etc. Fifty-five percent of patients were treated for postsurgical recurrent disease and 13% of patients had lymph node involvement at the time of treatment. The median duration of follow-up was 32 months (range 3-142 months). Actuarial curves for survival, cause-specific survival, local-regional control, and the development of distant metastases are presented for times out to 11 years. Results: The 5-year actuarial local-regional tumor control rate for the 151 patients with GRD was 57%; the 5-year actuarial overall survival rate was 72%; and the 5-year actuarial cause-specific survival rate was 77%. Variables associated with decreased local-regional control in the patients with GRD as determined by multivariate analysis included base of skull involvement (p

2000-02-01

143

Treatment of Locally Advanced Adenoid Cystic Carcinoma of the Trachea With Neutron Radiotherapy  

International Nuclear Information System (INIS)

Purpose: To examine the efficacy of fast neutron radiotherapy in the treatment of locally advanced adenoid cystic carcinoma (ACC) of the trachea and to compare outcomes with and without high-dose-rate (HDR) endobronchial brachytherapy boost. Methods and Materials: Between 1989 and 2005, a total of 20 patients with ACC of the trachea were treated with fast neutron radiotherapy at University of Washington. Of these 20 patients, 19 were treated with curative intent. Neutron doses ranged from 10.7 to 19.95 Gy (median, 19.2 Gy). Six of these patients received an endobronchial brachytherapy boost using an HDR 192Ir source (3.5 Gy x 2 fractions). Median duration of follow-up was 46 months (range, 10-121 months). Results: The 5-year actuarial overall survival rate and median overall survival for the entire cohort were 89.4%, and 97 months, respectively. Overall survival was not statistically different among those patients receiving an endobronchial boost compared with those receiving neutron radiotherapy alone (100% vs. 68%, p = 0.36). The 5-year actuarial locoregional control rate for the entire cohort was 54.1%. The locoregional control rate was not statistically different among patients who received an endobronchial boost compared with those who received neutron radiotherapy alone (40% vs. 58%, p 0.94). There were no cases of Grade ?3 acute toxicity. There were 2 cases of Grade 3/4 chronic toxicity. Conclusions: Fast neutron radiotherapy is an effective treatment for locally advanced adenoid cystic carcinoma of the trachea, with acceptable treatment-related toxicity

2008-10-01

144

Comparação entre a radiografia de cavum e a cefalométrica de perfil na avaliação da nasofaringe e das adenoides por otorrinolaringologistas/ Comparison between cavum and lateral cephalometric radiographs for the evaluation of the nasopharynx and adenoids by otorhinolaryngologists  

Scientific Electronic Library Online (English)

Full Text Available Abstract in portuguese INTRODUÇÃO: tanto a radiografia cefalométrica de perfil quanto a de cavum permitem a avaliação do espaço aéreo nasofaríngeo (EAN). Não é rara a solicitação dos otorrinolaringologistas de radiografia de cavum, mesmo o paciente possuindo uma cefalométrica. OBJETIVOS: objetivou-se (a) conhecer quais exames os otorrinolaringologistas solicitam para avaliar o EAN; (b) verificar o conhecimento da cefalométrica por otorrinolaringologistas; (c) comparar a avaliaçã (more) o de otorrinolaringologistas nas duas técnicas radiográficas para a medição e a visualização do EAN e da adenoide; (d) correlacionar os resultados do método de inspeção visual com os da medição de Schulhof. MÉTODOS: foram obtidas, no mesmo dia, radiografias cefalométricas e de cavum de 15 pacientes respiradores bucais. Essas foram cobertas com papel cartão, deixando visível apenas o EAN e adenoides e foram avaliadas por 12 otorrinolaringologistas. Estes respondiam sobre sua familiaridade com a cefalométrica, quais exames solicitam para visualizar EAN e adenoides e se utilizam algum método de medição do grau de obstrução. Avaliavam qual das radiografias apresentava a melhor visualização da adenoide e do EAN, e classificavam o tamanho dos mesmos em pequeno, médio ou grande, através de método visual. RESULTADOS: os resultados demonstraram que todos os otorrinolaringologistas costumam solicitar a radiografia de cavum. Apenas um solicita a cefalométrica, dois estão familiarizados com essa técnica e um utiliza algum método de medição do EAN. A cefalométrica foi preferida por 49,4% dos otorrinolaringologistas, a de cavum por 22,8%, enquanto 27,8% não observaram diferença entre ambas. Foi encontrada baixa correlação entre o método de medição visual e o de Schulhof. Abstract in english INTRODUCTION: The lateral cephalometric as well as the cavum radiograph allow the evaluation of the nasopharyngeal airway (NAW). Otorhinolaryngologists routinely use the cavum radiograph, even when the patient already has a lateral cephalometric headfilm. OBJECTIVES: The aim of this study was to (a) acknowledge which exams otorhinolaryngologists use for the evaluation and measurement of the NAW; (b) evaluate if the otorhinolaryngologists are acquainted to the cephalometri (more) c; (c) compare both radiographs to see which one is preferred to visualize the NAW and adenoids and (d) correlate the visual analysis to the measuring method of Schulhof. METHODS: For this purpose, the cephalometric and the cavum radiographs of 15 mouth-breathing children were taken on the same day. These radiographs were masked leaving only the NAW and the adenoids visible, and were blindly presented to 12 otorhinolaryngologists. They received the radiographs together with a questionnaire asking on their familiarity with the lateral cephalometric, which exams are used for NAW and adenoid evaluation and if they use any method for measuring the NAW obstruction level. They were also asked to visually classify the NAW and the adenoids according to their sizes into small, medium and large. RESULTS: The results demonstrated that all otorhinolaryngologists in the sample use the cavum radiograph. Only one uses the cephalometric radiograph and two are familiar to this technique. The cephalometric was preferred by 49.4% of the otorhinolaryngologists, the cavum by 22.8% and 27.8% did not see any difference between both methods. There was low correlation between the visual method and the Schulhof measuring method.

Almeida, Rhita Cristina Cunha; Artese, Flavia; Carvalho, Felipe de Assis Ribeiro; Cunha, Rachel Dias; Almeida, Marco Antonio de Oliveira

2011-02-01

145

Comparação entre a radiografia de cavum e a cefalométrica de perfil na avaliação da nasofaringe e das adenoides por otorrinolaringologistas Comparison between cavum and lateral cephalometric radiographs for the evaluation of the nasopharynx and adenoids by otorhinolaryngologists  

Directory of Open Access Journals (Sweden)

Full Text Available INTRODUÇÃO: tanto a radiografia cefalométrica de perfil quanto a de cavum permitem a avaliação do espaço aéreo nasofaríngeo (EAN). Não é rara a solicitação dos otorrinolaringologistas de radiografia de cavum, mesmo o paciente possuindo uma cefalométrica. OBJETIVOS: objetivou-se (a) conhecer quais exames os otorrinolaringologistas solicitam para avaliar o EAN; (b) verificar o conhecimento da cefalométrica por otorrinolaringologistas; (c) comparar a avaliação de otorrinolaringologistas nas duas técnicas radiográficas para a medição e a visualização do EAN e da adenoide; (d) correlacionar os resultados do método de inspeção visual com os da medição de Schulhof. MÉTODOS: foram obtidas, no mesmo dia, radiografias cefalométricas e de cavum de 15 pacientes respiradores bucais. Essas foram cobertas com papel cartão, deixando visível apenas o EAN e adenoides e foram avaliadas por 12 otorrinolaringologistas. Estes respondiam sobre sua familiaridade com a cefalométrica, quais exames solicitam para visualizar EAN e adenoides e se utilizam algum método de medição do grau de obstrução. Avaliavam qual das radiografias apresentava a melhor visualização da adenoide e do EAN, e classificavam o tamanho dos mesmos em pequeno, médio ou grande, através de método visual. RESULTADOS: os resultados demonstraram que todos os otorrinolaringologistas costumam solicitar a radiografia de cavum. Apenas um solicita a cefalométrica, dois estão familiarizados com essa técnica e um utiliza algum método de medição do EAN. A cefalométrica foi preferida por 49,4% dos otorrinolaringologistas, a de cavum por 22,8%, enquanto 27,8% não observaram diferença entre ambas. Foi encontrada baixa correlação entre o método de medição visual e o de Schulhof.INTRODUCTION: The lateral cephalometric as well as the cavum radiograph allow the evaluation of the nasopharyngeal airway (NAW). Otorhinolaryngologists routinely use the cavum radiograph, even when the patient already has a lateral cephalometric headfilm. OBJECTIVES: The aim of this study was to (a) acknowledge which exams otorhinolaryngologists use for the evaluation and measurement of the NAW; (b) evaluate if the otorhinolaryngologists are acquainted to the cephalometric; (c) compare both radiographs to see which one is preferred to visualize the NAW and adenoids and (d) correlate the visual analysis to the measuring method of Schulhof. METHODS: For this purpose, the cephalometric and the cavum radiographs of 15 mouth-breathing children were taken on the same day. These radiographs were masked leaving only the NAW and the adenoids visible, and were blindly presented to 12 otorhinolaryngologists. They received the radiographs together with a questionnaire asking on their familiarity with the lateral cephalometric, which exams are used for NAW and adenoid evaluation and if they use any method for measuring the NAW obstruction level. They were also asked to visually classify the NAW and the adenoids according to their sizes into small, medium and large. RESULTS: The results demonstrated that all otorhinolaryngologists in the sample use the cavum radiograph. Only one uses the cephalometric radiograph and two are familiar to this technique. The cephalometric was preferred by 49.4% of the otorhinolaryngologists, the cavum by 22.8% and 27.8% did not see any difference between both methods. There was low correlation between the visual method and the Schulhof measuring method.

Rhita Cristina Cunha Almeida; Flavia Artese; Felipe de Assis Ribeiro Carvalho; Rachel Dias Cunha; Marco Antonio de Oliveira Almeida

2011-01-01

146

Adenoid cystic carcinoma of the sinonasal tract: outcome of endonasal endoscopic surgery at five-year follow up.  

UK PubMed Central (United Kingdom)

OBJECTIVE: To study the outcome of endonasal endoscopic surgery for adenoid cystic carcinoma of the sinonasal tract over a five-year follow-up period. DESIGN: Retrospective analysis. METHODS: Four consecutive patients with adenoid cystic carcinoma of the sinonasal tract, who had undergone endonasal endoscopic surgery, were reviewed regarding age at diagnosis, sex, primary site, tumour-node-metastasis staging, treatment modalities, histopathological findings, duration of follow up, distant metastases and treatment outcome. RESULTS: All patients were diagnosed at an advanced stage and had post-operative adjuvant radiotherapy. Three patients underwent endoscopic endonasal resection and one endoscopic assisted craniofacial resection. The most common primary site was the ethmoid sinus (three patients). Three patients had no evidence of recurrence. One patient who had undergone partial clearance via endoscopic endonasal resection developed cervical node metastases a year after treatment; this patient also developed distant metastases. CONCLUSION: Adenoid cystic carcinoma is difficult to treat. Sinonasal tract tumours can be resected via endoscopic endonasal resection or endoscopic assisted craniofacial resection, but prolonged follow up is advisable. Radiotherapy is an important adjuvant treatment.

Gendeh BS; Zahedi FD; Ahmad H; Kew TY

2013-05-01

147

[Effects of silencing inhibitor of DNA binding-1 gene on the growth and invasiveness of adenoid cystic carcinoma cells].  

UK PubMed Central (United Kingdom)

OBJECTIVE: To investigate the role of inhibitor of DNA binding-1 (Id-1) gene in adenoid cystic carcinoma cell growth and invasion behavior. METHODS: With salivary adenoid cystic carcinoma cell lines ACC-M and ACC-2, dedected Id-1 gene expression was screened with immunofluorescence assay. After Id-1 mRNA knocking-down using small interfering RNA, RT-PCR and Western blot were used to detect the different expressions before and after interference, and the growth of cells before and after interference was deceted using the MTT assay, and the cell invasion ability was checked with the use of Transwell chamber assay. RESULTS: Id-1 were both expressed in the ACC-M and ACC-2, and the expression in ACC-M was higher than that in ACC-2. After Id-1 RNA interference, the growth and invasiveness of ACC-M and ACC-2 were inhibited with the restrained degree in ACC-M much stronger than that in the ACC-2. CONCLUSION: In view of the important role of Id-1 in the behavior of growth and invasion in ACC cell, interfering the expression of Id-1 gene is expected to be a novel and effective means for the treatment of adenoid cystic carcinoma.

Liu P; Zhang XH; Hu ZS; Sun SZ; Liu SH; Wei FC

2011-02-01

148

Cultivo primario de células ciliadas de adenoides humanos: Un modelo experimental para evaluar la actividad ciliar in vitro/ Primary culture of human adenoid ciliated cells: An experimental model to evaluate ciliar activity in vitro  

Scientific Electronic Library Online (English)

Full Text Available Abstract in spanish Introducción: El clearance mucociliar normal es el mecanismo de defensa básico de las vías respiratorias. Sin embargo, los mecanismos de control ciliar aún se desconocen. Con el fin de entenderlo mejor, se han desarrollado diferentes técnicas de cultivo de células ciliadas. Objetivos: Desarrollar un modelo experimental a partir de cultivos primarios de tejido adenoideo y cornete medio. Caracterizarla respuesta a adenosin trifosfato (ATP), agonista conocido de la fre (more) cuencia de batido ciliar (FBC). Material y método: Cultivos primarios a partir de explantes de epitelio adenoideo y cornete medio humano. Medición de FBC, con técnica de microfotodensitometría, en condición basal y en respuesta a ATP a diferentes concentraciones. Resultados: La FBC basal (promedio (X) ±desv estándar (DE)) para los cultivos de cornete medio fue 11,9 ±1,5 Hz y para tejido adenoideo fue 10,9 ±1,9 (p >0,05). Se observó un aumento en la FBC en respuesta a ATP, dosis dependiente. No hubo diferencia significativa en la FBC basal ni en la respuesta a ATP entre cultivos de cornete medio y adenoides. Conclusión: El cultivo primario de células ciliadas nasales a partir de explantes de adenoides, es un modelo experimental reproducible, en el que es posible observar actividad ciliary una respuesta funcional concordante con lo descrito en la literatura Abstract in english Introduction. Mucociliary clearance constitutes the main defense mechanism of the airway, but the mechanisms of ciliary control are still unknown. With the aim of a better understanding of this process, many ciliated cells culture techniques have been developed. Aims. 1. To develop an experimental model based on primary cultures from adenoid and middle turbinate tissue. 2. To characterize in this model the response to ATP, a known agonist of ciliary beat frequency (CBF). (more) Material and Method. Primary cultures derived from human adenoid tissue and middle turbinate epithelial explants were obtained. CFB was measured by microphotodensitometry, both in basal conditions and in response to ATP at different concentrations. Results. Basal CFB (average (X) +- standard deviation (SD)) for middle turbinate cultures was 11.9 +-1.5 Hz, and for adenoid tissue was 10.9 +-1.9 Hz (p

González, Claudia; Sánchez, Trinidad; Fonseca, Ximena; Villalón, Manuel

2007-08-01

149

Expression and clinical significance of FAK, ILK, and PTEN in salivary adenoid cystic carcinoma.  

UK PubMed Central (United Kingdom)

CONCLUSION: Focal adhesion kinase (FAK) and integrin-linked kinase (ILK) are highly expressed in salivary adenoid cystic carcinoma (SACC), especially metastatic SACC, suggesting their potential role as prognostic markers for SACC. OBJECTIVES: This study aimed to investigate the expression of FAK, ILK, and phosphatase and tensin homolog deleted on chromosome ten (PTEN) in SACC tissues and the clinical significance. METHODS: PAK and ILK expression in samples from 50 cases of SACC and 12 subjects with normal salivary glands was detected by immunohistochemical analysis. PAK and ILK expression in SACC cell lines was detected by RT-PCR and Western blot analysis. RESULTS: The positive rate of PAK and ILK staining was 94% (47/50) and 48% (24/50) in SACC, respectively, significantly higher than in normal salivary gland tissues (p < 0.05). However, the positive rate of PTEN staining was 30% (15/50), significantly lower than in normal salivary gland tissues (p < 0.05). Pearson analysis showed that FAK expression was positively correlated with ILK expression but negatively correlated with PTEN expression in SACC tissues. FAK and ILK expression was positively associated with advanced stage, solid histological subtype, perineural invasion, and distant metastasis of SACC (p < 0.05). In addition, FAK and ILK expression at both mRNA and protein levels was significantly higher in highly metastatic SACC-LM cells than low-metastatic SACC-83 cells.

Chen D; Zhang B; Kang J; Ma X; Lu Y; Gong L

2013-02-01

150

Prognostic value of nuclear volume in adenoid cystic carcinoma of the head and neck.  

UK PubMed Central (United Kingdom)

Modem stereologic techniques enable unbiased, objective and reproducible assessment of histologic parameters. The purpose of this study was to investigate the prognostic impact of the volume-weighted mean volume of tumor nuclei (nuclear (V) over bar v) in 62 patients with adenoid cystic carcinoma (ACC) and to correlate nuclear (V) over bar v and some traditional prognostic parameters with treatment failures. The observation time of the patients ranged from 2 to 11 years. Disregarding the well known histopathological subtypes of ACC and using random sampling it was found that treatment failures, i.e. inability to eradicate the disease and recurrences, were more often seen in specimens with small nuclear (V) over bar v when-compared to non-failures. Using a cut-off point of 250 mu m(3) the prognostic significance of nuclear (V) over bar v was 0.0177 by log rank analysis. For tumor stage vs. treatment failures/nonfailures log rank analysis revealed p=0.0147. Cox regression analysis left only the nuclear (V) over bar v (p=0.0234) as a prognostic factor. Estimations of nuclear (V) over bar v appears to be a reliable indicator of short term treatment failures in ACC.

Xie X; Stenersen T; Larsen P; Clausen O; Boysen M

1994-03-01

151

Sinonasal adenoid cystic carcinoma: comprehensive analysis of incidence and survival from 1973 to 2009.  

UK PubMed Central (United Kingdom)

OBJECTIVES/HYPOTHESIS: Sinonasal adenoid cystic carcinoma (SNACC) is a rare malignancy that most commonly arises in the maxillary sinus. Characteristics of SNACC are slow growth, perineural invasion, and long clinical course. Because it is a rare tumor, population-based studies are limited. We analyzed the incidence and survival for SNACC using a national population-based database. STUDY DESIGN: Retrospective cohort study using national cancer database. METHODS: The United States National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) registry was utilized to calculate incidence and survival trends for SNACC between 1973 and 2009. Patient data were then analyzed according to age, sex, and race. Incidence trends were studied for the last 30 years, and survival outcomes were compared across the different demographic parameters. RESULTS: A total of 412 cases of SNACC were identified (57.52% female). Incidence trend analysis revealed a significant decrease in yearly rates from 1973 to 2009 for the overall population, females, whites, blacks, and "others." Overall 5-year survival for SNACC was 68.80%, 10-year survival was 48.03%, and 20-year survival was 22.39%. Significant differences in survival outcomes were noted between whites, blacks, and "others." "Others" had the best 20-year survival outcomes. CONCLUSIONS: The overall incidence of SNACC is declining. Sex and race seem to influence the overall survival for this rare tumor. Future studies need to be conducted to investigate these dynamic trends related to SNACC.

Sanghvi S; Patel NR; Patel CR; Kalyoussef E; Baredes S; Eloy JA

2013-07-01

152

The penetration of erythromycin into Waldeyer's ring--tonsil and adenoid tissue.  

Science.gov (United States)

Erythromycin ethylsuccinate was given orally (30-60 mg/kg/day) to 72 otherwise healthy children for different intervals before adenoidectomy. The concentration of erythromycin was assessed in homogenized tissue, in whole blood and in plasma, making it possible to calculate blood-free tissue levels. The tissue levels (1.5-2.0 mg/l) were the same as the plasma levels. Six patients with chronic tonsillitis were given 1000 mg erythromycin ethylsuccinate via a gastric tube, and tonsillectomy à froid was performed three to five hours later. This unusual mode of administration was chosen to avoid tonsil surface contamination, which might cause artificially high values. The concentration of erythromycin was assessed as described above. The levels of erythromycin in the tonsil tissue were the same as the concomitant plasma levels. Erythromycin has been shown to penetrate into adenoid and tonsil tissue and to attain levels similar to the simultaneous plasma levels. It may be inferred from this study that erythromycin penetrates into other lymphatic localities to the same degree. PMID:6980840

Sundberg, L; Edén, T; Ernstson, S

1982-01-01

153

The penetration of erythromycin into Waldeyer's ring--tonsil and adenoid tissue.  

UK PubMed Central (United Kingdom)

Erythromycin ethylsuccinate was given orally (30-60 mg/kg/day) to 72 otherwise healthy children for different intervals before adenoidectomy. The concentration of erythromycin was assessed in homogenized tissue, in whole blood and in plasma, making it possible to calculate blood-free tissue levels. The tissue levels (1.5-2.0 mg/l) were the same as the plasma levels. Six patients with chronic tonsillitis were given 1000 mg erythromycin ethylsuccinate via a gastric tube, and tonsillectomy à froid was performed three to five hours later. This unusual mode of administration was chosen to avoid tonsil surface contamination, which might cause artificially high values. The concentration of erythromycin was assessed as described above. The levels of erythromycin in the tonsil tissue were the same as the concomitant plasma levels. Erythromycin has been shown to penetrate into adenoid and tonsil tissue and to attain levels similar to the simultaneous plasma levels. It may be inferred from this study that erythromycin penetrates into other lymphatic localities to the same degree.

Sundberg L; Edén T; Ernstson S

1982-01-01

154

Adenoid cystic carcinoma of the oral cavity: immunohistochemical study of four cases  

Science.gov (United States)

Adenoid cystic carcinoma (ACC) in the oral cavity is rare, and no immunohistochemical studies of ACC in the oral cavity have been performed. This report describes the immunohistochemical study of four ACCs of the oral cavity. The male to female ratio was 1:3. The age was 43, 51, 59 and 64 years. The location was tongue (n=2), buccal mucosa (n=1), and gingiva (n=1). Histochemically, all ACCs were positive for neutral, carboxylated and sulfated mucins. Immunohistochemically, ACC was consistently positive for cytokeratin (CK) AE1/3, CK 34?E12, CK5/6, CK7, CK14, CK18, p63, CA19-9, c-KIT (CD117), PDGFRA, MUC1, and Ki-67 (labeling index: 5%, 15%, 20% and 40%). ACC was consistently negative for CK8, CK20, desmin, S100 protein, CD34, chromogranin, MUC2, MUC5AC and MUC6. Some ACCs were positive for CK CAM5.2 (3/4), CK19 (1/4), EMA (2/4), CEA (2/4), vimentin (3/4), ?-smooth muscle actin (2/4), p53 (2/4), CD10 (2/4), and synaptophysin (1/4). These results may provide basic knowledge of ACC of the oral cavity.

Terada, Tadashi

2013-01-01

155

Molecular and morphological analysis of adenoid cystic carcinoma of the breast with synchronous tubular adenosis.  

UK PubMed Central (United Kingdom)

Adenoid cystic carcinoma (ACC) of the breast is a rare tumour. Its recognition as a special type of breast carcinoma is very important because its prognosis is better than the not-otherwise-specified invasive ductal carcinoma and its treatment may not include axillary dissection. Tubular adenosis (TA) is a very rare condition of the breast that is histologically benign; however, it has been described in association with invasive ductal carcinoma. There are scant data regarding the molecular genomic alterations in ACC of the breast and no data has been presented on TA. Herein, we provide a morphological characterisation of TA arising synchronically with ACC in the breast. To characterise these lesions, we performed ultrastructural analysis, three-dimensional reconstruction and molecular analysis using immunohistochemistry and comparative genomic hybridisation. The copy number alterations found in ACC were restricted to small deletions on 16p and 17q only, whereas the TA harboured gains on 1q, 5p, 8q, 10q, 11p and 11q and losses on 1p, 10q, 11q, 12q, 14q, 15q and 16q. These molecular data highlight the genomic instability of TA, a benign florid proliferation intermingled with ACC, and do not provide evidence of molecular evolution from TA to ACC.

Da Silva L; Buck L; Simpson PT; Reid L; McCallum N; Madigan BJ; Lakhani SR

2009-01-01

156

Molecular and morphological analysis of adenoid cystic carcinoma of the breast with synchronous tubular adenosis.  

Science.gov (United States)

Adenoid cystic carcinoma (ACC) of the breast is a rare tumour. Its recognition as a special type of breast carcinoma is very important because its prognosis is better than the not-otherwise-specified invasive ductal carcinoma and its treatment may not include axillary dissection. Tubular adenosis (TA) is a very rare condition of the breast that is histologically benign; however, it has been described in association with invasive ductal carcinoma. There are scant data regarding the molecular genomic alterations in ACC of the breast and no data has been presented on TA. Herein, we provide a morphological characterisation of TA arising synchronically with ACC in the breast. To characterise these lesions, we performed ultrastructural analysis, three-dimensional reconstruction and molecular analysis using immunohistochemistry and comparative genomic hybridisation. The copy number alterations found in ACC were restricted to small deletions on 16p and 17q only, whereas the TA harboured gains on 1q, 5p, 8q, 10q, 11p and 11q and losses on 1p, 10q, 11q, 12q, 14q, 15q and 16q. These molecular data highlight the genomic instability of TA, a benign florid proliferation intermingled with ACC, and do not provide evidence of molecular evolution from TA to ACC. PMID:19031084

Da Silva, Leonard; Buck, Lyndall; Simpson, Peter T; Reid, Lynne; McCallum, Naomi; Madigan, Barry J; Lakhani, Sunil R

2008-11-25

157

HHV-6 is ubiquitously found using Western blot in tonsils and adenoid tissues of healthy people.  

UK PubMed Central (United Kingdom)

UNLABELLED: Few studies have examined the prevalence and cellular proclivity of latent human herpesvirus 6 (HHV-6) in healthy populations. Difficulties in detection of HHV-6 genome in different tissues using polymerase chain reaction (PCR) and immunohistochemistry (IHC) techniques have been reported by various researchers. We examined tonsils and adenoid tissues of 54 patients who had undergone tonsillectomy or adenoidectomy without any evidence of acute infection for the presence of latent HHV-6 infection. While we were investigating the prevalence of HHV-6, we tested the efficiency of PCR, IHC and Western Blot (WB) for detection of HHV-6 in tonsil tissues. We found that 100% of tonsil tissues were positive for HHV-6 with WB, 40% of tonsils were positive with PCR and no tonsil was positive with IHC. This result correlates well with most studies claiming HHV-6 is a ubiquitous organism in various populations and tissues. Western blot may be a good choice for detecting HHV-6 in tissues. Expression of the HHV-6 gp60/110 envelope protein disclosed by WB may indicate that HHV-6 does not have true latency. To our knowledge, this is the first report to use WB to test for HHV-6 in tissues. KEY WORDS: Human herpes virus 6, Polymerase chain reaction, Western blot.

Taspinar M; Cetin N; Gerceker D; Karasartova D; T Reg N B; Ozturk S; Sahin F

2013-07-01

158

[Application of Xstrain in the evaluation of heart function in children with tonsil adenoidal hypertrophy].  

UK PubMed Central (United Kingdom)

OBJECTIVE: To study the value of Xstrain technology in the evaluation of cardiac function in children with tonsil adenoidal hypertrophy (TAH). METHODS: Thirty-five children with TAH (TAH group) and 20 normal age-matched children (control group) were enrolled. The left ventricular wall movement in the vertical, radial and circumferential directions and the right ventricular tricuspid annulus movement were detected using Xstrain technology. RESULTS: The systolic and early diastolic velocities of tricuspid annulus in the TAH group were higher than those in the control group. The systolic and diastolic circumferential velocities of the middle lateral wall and back wall of left ventricular in the TAH group were lower than those in the control group. The systolic and early diastolic vertical velocities of the basement of left ventricular wall in the TAH group were higher than those in the control group. There was no significant difference in the radial velocity between the two groups. CONCLUSIONS: Early changes in the cardiac function can be found by Xstrain technology in children with TAH. Xstrain technology can provide a reliable basis for cardiovascular evaluation in children with TAH.

Mei L; Yang XY; Wang RL; Zhang J; Ge D

2009-05-01

159

Intracranial extension of adenoid cystic carcinoma of the palate: a case report  

International Nuclear Information System (INIS)

Intracranial involvement by adenoid cystic carcinoma (ACC) is very rare and there is no report of intracranial extension from the palate ACC in Korea. Intracranial involvement can occur in one of three ways: direct extension, perineural spread, and hematogenous spread. A case report of a 35-year-old woman with intracranial ACC is presented. Initially she had ACC of the right palate and was treated by surgery and postoperative radiation therapy. Three years and 10 months later, the paresthesia in the distribution of ophthalmic and maxillary branch of right trigeminal nerve developed without evidence of recurrence in CT scan. Ptosis and total ophthalmoplegia developed sequentially and the second operation was performed. It was suggested that the tumor was spread perineurally along the trigeminal nerve into the Gasserian ganglion and then cavernous sinus and orbit. Seven years and 6 months after the first operation, direct intracranial extension into the right temporal lobe developed via sphenoid bone, sphenoid sinus and temporal bone and the third operation was done. And then Jung metastasis was diagnosed. She is alive for 9 years 5 months after first operation.

1999-01-01

160

Adenoid cystic carcinoma of the oral cavity: immunohistochemical study of four cases.  

Science.gov (United States)

Adenoid cystic carcinoma (ACC) in the oral cavity is rare, and no immunohistochemical studies of ACC in the oral cavity have been performed. This report describes the immunohistochemical study of four ACCs of the oral cavity. The male to female ratio was 1:3. The age was 43, 51, 59 and 64 years. The location was tongue (n=2), buccal mucosa (n=1), and gingiva (n=1). Histochemically, all ACCs were positive for neutral, carboxylated and sulfated mucins. Immunohistochemically, ACC was consistently positive for cytokeratin (CK) AE1/3, CK 34?E12, CK5/6, CK7, CK14, CK18, p63, CA19-9, c-KIT (CD117), PDGFRA, MUC1, and Ki-67 (labeling index: 5%, 15%, 20% and 40%). ACC was consistently negative for CK8, CK20, desmin, S100 protein, CD34, chromogranin, MUC2, MUC5AC and MUC6. Some ACCs were positive for CK CAM5.2 (3/4), CK19 (1/4), EMA (2/4), CEA (2/4), vimentin (3/4), ?-smooth muscle actin (2/4), p53 (2/4), CD10 (2/4), and synaptophysin (1/4). These results may provide basic knowledge of ACC of the oral cavity. PMID:23638226

Terada, Tadashi

2013-04-15

 
 
 
 
161

Adenoid cystic carcinoma of the oral cavity: immunohistochemical study of four cases.  

UK PubMed Central (United Kingdom)

Adenoid cystic carcinoma (ACC) in the oral cavity is rare, and no immunohistochemical studies of ACC in the oral cavity have been performed. This report describes the immunohistochemical study of four ACCs of the oral cavity. The male to female ratio was 1:3. The age was 43, 51, 59 and 64 years. The location was tongue (n=2), buccal mucosa (n=1), and gingiva (n=1). Histochemically, all ACCs were positive for neutral, carboxylated and sulfated mucins. Immunohistochemically, ACC was consistently positive for cytokeratin (CK) AE1/3, CK 34?E12, CK5/6, CK7, CK14, CK18, p63, CA19-9, c-KIT (CD117), PDGFRA, MUC1, and Ki-67 (labeling index: 5%, 15%, 20% and 40%). ACC was consistently negative for CK8, CK20, desmin, S100 protein, CD34, chromogranin, MUC2, MUC5AC and MUC6. Some ACCs were positive for CK CAM5.2 (3/4), CK19 (1/4), EMA (2/4), CEA (2/4), vimentin (3/4), ?-smooth muscle actin (2/4), p53 (2/4), CD10 (2/4), and synaptophysin (1/4). These results may provide basic knowledge of ACC of the oral cavity.

Terada T

2013-01-01

162

PIK3CA and PTEN mutations in adenoid cystic carcinoma of the breast metastatic to kidney.  

UK PubMed Central (United Kingdom)

Adenoid cystic carcinoma (ACC) of the breast rarely metastasizes and has been associated with excellent prognosis. We describe a patient with renal metastasis of primary breast ACC 5 years after the mastectomy. A detailed molecular genetic analysis of the primary and metastatic tumors demonstrated somatic mutations in 2 well-known cancer genes associated with regulation of PI3K/AKT signaling pathway: (1) PIK3CA, which encodes the catalytic alpha subunit of the phosphoinositide-3-kinase, and (2) PTEN, which encodes phosphatase and tensin homolog. The mutation identified in PIK3CA (Ex1+169 A>C) predicts an amino acid change from isoleucine to methionine at codon 31 (I31M) and resides in the p85-binding domain of exon 1. The mutation identified in PTEN (IVS4-3 C>T) resides in intron 4 near the splice acceptor site of exon 5 and was associated with an aberrant PTEN transcript lacking exon 5, which is necessary for protein tyrosine phosphatase function and tumor suppressor properties of PTEN. Increased promoter methylation of PTEN was present in renal metastasis, coinciding with the decrease in the level of normal PTEN transcript. These coexistent mutations/epigenetic inactivations in PI3K/AKT pathway may be responsible for the unusually aggressive course of ACC.

Vrani? S; Bilalovi? N; Lee LM; Kruslin B; Lilleberg SL; Gatalica Z

2007-09-01

163

Feasibility and toxicity of combined photon and carbon ion radiotherapy for locally advanced adenoid cystic carcinomas.  

UK PubMed Central (United Kingdom)

PURPOSE: To investigate clinical feasibility and toxicity of combined photon and carbon ion radiotherapy in locally advanced adenoid cystic carcinomas (ACC) within a prospective Phase I/II trial. METHODS AND MATERIALS: Between September 1998 and April 2002, 16 patients with histopathologically proven ACC and residual macroscopic tumor were treated with combined photon RT and a carbon ion boost to the macroscopic tumor. Median total tumor dose within the gross tumor volume (GTV) was 72 GyE. Photon radiation therapy (RT) consisted of fractionated stereotactic RT in 7 patients; 9 patients received stereotactic intensity-modulated RT. Carbon ion boost was delivered by intensity-controlled raster scanning at the heavy ion synchrotron (SIS) at the Heavy Ion Research Center (GSI) in Darmstadt. RESULTS: Median follow-up was 12 months. Three patients developed locoregional recurrences 9, 11, and 24 months after RT, respectively. Actuarial local control rates were 80.8% and 64.6% at 1 and 3 years, respectively. Overall survival rates were 100% and 83.3% at 1 and 3 years, respectively. Acute side effects greater than Common Toxicity Criteria (CTC) Grade 2 were observed in 2 patients; no patient developed late effects > CTC Grade 2. CONCLUSIONS: Combined photon and carbon ion RT is feasible and effective in patients with locally advanced ACC. Acute and late toxicity is moderate with respect to the delivered tumor doses and in accordance with the radiobiologic modeling. A Phase III trial is designed.

Schulz-Ertner D; Nikoghosyan A; Jäkel O; Haberer T; Kraft G; Scholz M; Wannenmacher M; Debus J

2003-06-01

164

Developmental transcription factor EN1--a novel biomarker in human salivary gland adenoid cystic carcinoma.  

UK PubMed Central (United Kingdom)

Adenoid cystic carcinoma (ACC), a rare and progressive salivary malignancy, is characterized by histogenetic, morphologic, and clinical heterogeneity. Extensive efforts to characterize the molecular events associated with these tumors have included the identification of biomarkers for prognostication and post-therapy assessment. In a previous study of genome-wide methylation screening, the authors of the current report identified a limited number of differentially methylated gene regions in ACC, and significant hypermethylation was observed at the transcriptional start sites of genes that encode for the transcription factor engrailed homeobox 1 (EN1). Clinicopathologic correlation analyses indicated that EN1 methylation status is correlated with histologic tumor grade, tumor location, and final patient outcome. To ascertain definitively whether aberrant EN1 expression accompanies human salivary ACC, the authors used an immunohistochemical technique to directly evaluate EN1 protein expression in ACC of the salivary gland. The data revealed increased EN1 protein expression in solid type ACC, which was correlated with a significantly lower survival rate. The current results validated EN1 as a potential biomarker in a large cohort of patients with salivary ACC. Immunohistochemical analysis of EN1 in biopsy specimens obtained for diagnostic purposes and/or surgically resected material may reveal that EN1 is a biologic predictor of poor prognosis in patients with salivary ACC.

Bell D; Bell A; Roberts D; Weber RS; El-Naggar AK

2012-03-01

165

Developmental transcription factor EN1--a novel biomarker in human salivary gland adenoid cystic carcinoma.  

Science.gov (United States)

Adenoid cystic carcinoma (ACC), a rare and progressive salivary malignancy, is characterized by histogenetic, morphologic, and clinical heterogeneity. Extensive efforts to characterize the molecular events associated with these tumors have included the identification of biomarkers for prognostication and post-therapy assessment. In a previous study of genome-wide methylation screening, the authors of the current report identified a limited number of differentially methylated gene regions in ACC, and significant hypermethylation was observed at the transcriptional start sites of genes that encode for the transcription factor engrailed homeobox 1 (EN1). Clinicopathologic correlation analyses indicated that EN1 methylation status is correlated with histologic tumor grade, tumor location, and final patient outcome. To ascertain definitively whether aberrant EN1 expression accompanies human salivary ACC, the authors used an immunohistochemical technique to directly evaluate EN1 protein expression in ACC of the salivary gland. The data revealed increased EN1 protein expression in solid type ACC, which was correlated with a significantly lower survival rate. The current results validated EN1 as a potential biomarker in a large cohort of patients with salivary ACC. Immunohistochemical analysis of EN1 in biopsy specimens obtained for diagnostic purposes and/or surgically resected material may reveal that EN1 is a biologic predictor of poor prognosis in patients with salivary ACC. PMID:21800291

Bell, Diana; Bell, Achim; Roberts, Dianna; Weber, Randal S; El-Naggar, Adel K

2011-07-28

166

Literature review on the role of radiotherapy in the treatment of nasopharyngeal cystic adenoid carcinomas about two cases  

International Nuclear Information System (INIS)

The authors discuss the characteristics and the radiotherapy treatment procedures of cystic adenoid carcinomas, and more precisely the treatment of two of such cases of nasopharyngeal carcinomas. The first one had an incomplete resection surgery followed by curing radiotherapy: he has then been in local-regional control situation for 8 months. The second one had lung metastases, was treated chemotherapy and radiotherapy (decompressive treatment), and died six months after diagnosis. Radiotherapy is considered to be the treatment basis, whereas chemotherapy is a matter of controversy. Short communication

2011-01-01

167

Treatment of locally advanced adenoid cystic carcinoma of the head and neck with neutron radiotherapy.  

UK PubMed Central (United Kingdom)

PURPOSE: To examine the efficacy of fast neutron radiotherapy for the treatment of locally advanced and/or recurrent adenoid cystic carcinoma of the head and neck and to identify prognostic variables associated with local-regional control and survival. METHODS AND MATERIALS: One hundred fifty-nine patients with nonmetastatic, previously unirradiated, locally advanced, and/or recurrent adenoid cystic carcinoma (ACC) of the head and neck region were treated with fast neutron radiotherapy during the years 1985-1997. One hundred fifty-one patients had either unresectable disease, or gross residual disease (GRD) after an attempted surgical extirpation. Eight patients had microscopic residual disease and were analyzed separately. Sixty-two percent of patients had tumors arising in minor salivary glands, 29% in major salivary glands, and 9% in other sites such as the lacrimal glands, tracheal-bronchial tree, etc. Fifty-five percent of patients were treated for postsurgical recurrent disease and 13% of patients had lymph node involvement at the time of treatment. The median duration of follow-up was 32 months (range 3-142 months). Actuarial curves for survival, cause-specific survival, local-regional control, and the development of distant metastases are presented for times out to 11 years. RESULTS: The 5-year actuarial local-regional tumor control rate for the 151 patients with GRD was 57%; the 5-year actuarial overall survival rate was 72%; and the 5-year actuarial cause-specific survival rate was 77%. Variables associated with decreased local-regional control in the patients with GRD as determined by multivariate analysis included base of skull involvement (p < 0.01) and biopsy only versus an attempted surgical resection prior to treatment (p = 0.03). Patients without these negative factors had an actuarial local-regional control rate of 80% at 5 years. Patients with microscopic residual disease (n = 8) had a 5-year actuarial local-regional control rate of 100%. Base of skull involvement (p < 0.001), lymph node metastases at the time of treatment (p < 0.01), biopsy only prior to neutron radiotherapy (p = 0.03), and recurrent tumors (p = 0.04) were found to be associated with a diminished cause-specific survival as ascertained by multivariate analysis. Patients with base of skull involvement and positive lymph nodes at presentation had an increased rate of the development of distant metastases at 5 years, (p < 0.01 and p < 0.001, respectively). No statistical difference in outcome was observed between major and minor salivary gland sites. CONCLUSIONS: Fast neutron radiotherapy is an effective treatment for locally advanced ACC of the head and neck region with acceptable toxicity. Further improvements in local-regional control are not likely to impact survival until more effective systemic agents are developed to prevent and/or treat distant metastatic disease.

Douglas JG; Laramore GE; Austin-Seymour M; Koh W; Stelzer K; Griffin TW

2000-02-01

168

Management of Adenoid Cystic Carcinoma of the Breast: A Rare Cancer Network Study  

International Nuclear Information System (INIS)

[en] Background: Mammary adenoid cystic carcinoma (ACC) is a rare breast cancer. The aim of this retrospective study was to assess prognostic factors and patterns of failure, as well as the role of radiation therapy (RT), in ACC. Methods: Between January 1980 and December 2007, 61 women with breast ACC were treated at participating centers of the Rare Cancer Network. Surgery consisted of lumpectomy in 41 patients and mastectomy in 20 patients. There were 51(84%) stage pN0 and 10 stage cN0 (16%) patients. Postoperative RT was administered to 40 patients (35 after lumpectomy, 5 after mastectomy). Results: With a median follow-up of 79 months (range, 6–285), 5-year overall and disease-free survival rates were 94% (95% confidence interval [CI], 88%–100%) and 82% (95% CI, 71%–93%), respectively. The 5-year locoregional control (LRC) rate was 95% (95% CI, 89%–100%). Axillary lymph node dissection or sentinel node biopsy was performed in 84% of cases. All patients had stage pN0 disease. In univariate analysis, survival was not influenced by the type of surgery or the use of postoperative RT. The 5-year LRC rate was 100% in the mastectomy group versus 93% (95% CI, 83%–100%) in the breast-conserving surgery group, respectively (p = 0.16). For the breast-conserving surgery group, the use of RT significantly correlated with LRC (p = 0.03); the 5-year LRC rates were 95% (95% CI, 86%–100%) for the RT group versus 83% (95% CI, 54%–100%) for the group receiving no RT. No local failures occurred in patients with positive margins, all of whom received postoperative RT. Conclusion: Breast-conserving surgery is the treatment of choice for patients with ACC breast cancer. Axillary lymph node dissection or sentinel node biopsy might not be recommended. Postoperative RT should be proposed in the case of breast-conserving surgery.

2012-04-01

169

Cisplatin-based chemotherapy in advanced adenoid cystic carcinoma of the head and neck.  

UK PubMed Central (United Kingdom)

Nineteen patients, nine men and 10 women, with advanced adenoid cystic carcinoma (ACC), were treated with cisplatin either alone or in combination with doxorubicin and bleomycin. Median age was 51 years (range: 32-73 years). Two groups of patients were distinguished: Group 1 (N = 10) received single-agent cisplatin (50-120 mg/m2 IV every 4 weeks) for locoregional recurrence (N = 4), pulmonary metastases (N = 5), or as neoadjuvant therapy (N = 1). Five patients failed previous chemotherapy. No objective responses were observed, five patients showed stabilization of their disease for a median duration of 20 months (range: 3-50 months). Group 2 (N = 9) received a combination of cisplatin (20 mg/m2 IV on days 1-5), doxorubicin (50 mg/m2 IV on day 1), and bleomycin (30 mg IV on days 1-5), every 3 weeks. A complete remission (CR) was seen in one patient, lasting for 2 years, a partial remission (PR) in two patients (duration: 6 months and 6 years) (33%), and a stable disease (SD) in five patients (median duration: 15 months; range 3-24 months). One patient showed progression from the start. The observed toxicity was acceptable: dose reduction was required in five patients for myelosuppression or impairment of renal function; vomiting grade III (WHO) was seen in 10 patients. The median progression-free survival was 36 months (range: 7-77 months). Median overall survival was 81 months (range: 14-216 months). The role of cisplatin in this disease remains questionable.

de Haan LD; De Mulder PH; Vermorken JB; Schornagel JH; Vermey A; Verweij J

1992-07-01

170

Cisplatin-based chemotherapy in advanced adenoid cystic carcinoma of the head and neck.  

Science.gov (United States)

Nineteen patients, nine men and 10 women, with advanced adenoid cystic carcinoma (ACC), were treated with cisplatin either alone or in combination with doxorubicin and bleomycin. Median age was 51 years (range: 32-73 years). Two groups of patients were distinguished: Group 1 (N = 10) received single-agent cisplatin (50-120 mg/m2 IV every 4 weeks) for locoregional recurrence (N = 4), pulmonary metastases (N = 5), or as neoadjuvant therapy (N = 1). Five patients failed previous chemotherapy. No objective responses were observed, five patients showed stabilization of their disease for a median duration of 20 months (range: 3-50 months). Group 2 (N = 9) received a combination of cisplatin (20 mg/m2 IV on days 1-5), doxorubicin (50 mg/m2 IV on day 1), and bleomycin (30 mg IV on days 1-5), every 3 weeks. A complete remission (CR) was seen in one patient, lasting for 2 years, a partial remission (PR) in two patients (duration: 6 months and 6 years) (33%), and a stable disease (SD) in five patients (median duration: 15 months; range 3-24 months). One patient showed progression from the start. The observed toxicity was acceptable: dose reduction was required in five patients for myelosuppression or impairment of renal function; vomiting grade III (WHO) was seen in 10 patients. The median progression-free survival was 36 months (range: 7-77 months). Median overall survival was 81 months (range: 14-216 months). The role of cisplatin in this disease remains questionable. PMID:1381339

de Haan, L D; De Mulder, P H; Vermorken, J B; Schornagel, J H; Vermey, A; Verweij, J

171

Therapy strategies for locally advanced adenoid cystic carcinomas using modern radiation therapy techniques.  

UK PubMed Central (United Kingdom)

BACKGROUND: The authors evaluated whether modern photon techniques, such as stereotactic fractionated radiation therapy (FSRT) or intensity-modulated RT, outweighed the biologic advantages of high-linear-energy transfer RT in the treatment of patients with locally advanced adenoid cystic carcinomas (ACC) that infiltrated the skull base or the orbit. METHODS: Between June 1995 and December 2003, 63 patients with ACC were treated with modern RT techniques at the University of Heidelberg. The treatment results achieved with modern photon techniques alone were compared with the results achieved with combined photon RT and a carbon ion boost. Twenty-nine patients (Group A) were treated with a combination of photon RT and a carbon ion boost. Thirty-four patients (Group B) received photon RT alone. RESULTS: The median follow-up was 16 months for Group A and 24 months for Group B. Locoregional control rates at 2 years and 4 years were 77.5% and 77.5% for Group A and 72.2% and 24.6% for Group B, respectively (P = 0.08; log-rank test). Disease-free and overall survival rates at 2 years/4 years were 71.5%/53% and 86.6%/75.8% for Group A and 69.2%/23% and 77.9%/77.9% for Group B, respectively. Rates for severe late toxicity were < 5% for both groups. CONCLUSIONS: Modern RT techniques allowed the safe delivery of high target doses to patients with locally advanced ACC. Late toxicity rates were kept lower compared with the historic neutron therapy data. A combination of modern photon RT and carbon ion RT seemed to be advantageous, with a trend toward higher locoregional control rates compared with modern photon RT alone.

Schulz-Ertner D; Nikoghosyan A; Didinger B; Münter M; Jäkel O; Karger CP; Debus J

2005-07-01

172

Adenoid cystic carcinoma of the parotid gland: Anastamosis of the facial nerve with the great auricular nerve after radical parotidectomy  

Directory of Open Access Journals (Sweden)

Full Text Available Adenoid cystic carcinoma of the parotid gland is a rare and slowly growing, but highly malignant tumor. Surgical resection of a malignant parotid tumor should include resection of the facial nerve when the nerve is involved in the tumor. Facial nerve reconstruction is required after nerve resection. A 14 year-old female presented with complaints of painless enlargement of the right parotid gland and facial asymmetry. Physical examination revealed a firm mass in the region of the parotid gland as well as right facial paralysis. Biopsy obtained from the mass showed an adenoid cystic carcinoma of the parotid gland. A radical parotidectomy with a modified radical neck dissection was carried out. Grafting material for the facial reconstruction was harvested from the great auricular nerve. The proximal main trunk and each distal branch of the facial nerve were coapted with the greater auricular nerve. The patient received radiotherapy after surgery and was seen to achieve grade IV facial function one year after surgery. Thus, the great auricular nerve is appropriate grafting material for coaptation of each distal branch of the facial nerve.

Bahadir Osman; Livaoglu Murat; Ural Ahmet

2008-01-01

173

Expression of p-AKT characterizes adenoid cystic carcinomas of head and neck with a higher risk for tumor relapses.  

UK PubMed Central (United Kingdom)

BACKGROUND: Adenoid cystic carcinomas are rare tumors with an indolent clinical course, but frequent local relapses. The identification of tumors with a higher relapse risk seems to be interesting. Hence we investigated parameters of glucose metabolism, which were found associated with poor prognosis in other malignancies. METHODS: Specimen of 29 patients were investigated immunohistochemically with antibodies against p-AKT, TKTL-1 (transketolase-like 1), M2PK (M2 pyruvate kinase), and GLUT-1. Proliferation was investigated by staining with Ki67. The tumors were located at the major or minor salivary glands. Only the typical cribriform subtype was investigated. The initial tumor stage was pT1 or pT2. RESULTS: Expression of p-AKT was significantly (P = 0.036) associated with a higher relapse risk in multivariate analysis. Low expression of M2PK was non-significantly (P = 0.065) predictive for a higher risk. TKTL-1 and GLUT-1 were expressed in the majority of cases, albeit not associated with relapse risk. CONCLUSION: Adenoid cystic carcinomas positive for p-AKT show a higher relapse risk. However, other parameters of glucose metabolism investigated here or proliferation (Ki67) were not predictive in this entity. Our findings demonstrate a possible background for therapeutic approaches targeting the inhibition of PI3K/AKT pathway.

Völker HU; Scheich M; Berndt A; Haubitz I; Metzger A; Müller-Hermelink HK; Kämmerer U; Schmidt M

2009-01-01

174

Expression of p-AKT characterizes adenoid cystic carcinomas of head and neck with a higher risk for tumor relapses  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background Adenoid cystic carcinomas are rare tumors with an indolent clinical course, but frequent local relapses. The identification of tumors with a higher relapse risk seems to be interesting. Hence we investigated parameters of glucose metabolism, which were found associated with poor prognosis in other malignancies. Methods Specimen of 29 patients were investigated immunohistochemically with antibodies against p-AKT, TKTL-1 (transketolase-like 1), M2PK (M2 pyruvate kinase), and GLUT-1. Proliferation was investigated by staining with Ki67. The tumors were located at the major or minor salivary glands. Only the typical cribriform subtype was investigated. The initial tumor stage was pT1 or pT2. Results Expression of p-AKT was significantly (P = 0.036) associated with a higher relapse risk in multivariate analysis. Low expression of M2PK was non-significantly (P = 0.065) predictive for a higher risk. TKTL-1 and GLUT-1 were expressed in the majority of cases, albeit not associated with relapse risk. Conclusion Adenoid cystic carcinomas positive for p-AKT show a higher relapse risk. However, other parameters of glucose metabolism investigated here or proliferation (Ki67) were not predictive in this entity. Our findings demonstrate a possible background for therapeutic approaches targeting the inhibition of PI3K/AKT pathway.

Völker Hans-Ullrich; Scheich Matthias; Berndt Annette; Haubitz Imme; Metzger Alexandra; Müller-Hermelink Hans-Konrad; Kämmerer Ulrike; Schmidt Melanie

2009-01-01

175

A retrospective study of 18 cases of adenoid cystic cancer at a tertiary care centre in Delhi  

Directory of Open Access Journals (Sweden)

Full Text Available Context: Adenoid cystic carcinoma (ACC) is a rare neoplasm that usually arises from the salivary, lacrimal, or other exocrine glands. It is characteristically locally infiltrative in nature and has a tendency toward local recurrence, high propensity for perineural invasion, and prolonged clinical course. Aim: To analyze the presentation and natural history of cases of adenoid cystic tumors of salivary glands in our institution; and to compare with the existing literature. Design and Setting: Retrospective study at the Department of Radiotherapy. Materials and Methods: Data on 18 patients of ACC of the salivary glands treated between 2004 and 2008 were reviewed with respect to clinical presentation, stage, and histology. Results: There were 8 cases of major salivary gland tumors (47%), of which 2 were in the submandibular and 6 were involving the parotid. Ten patients (53%) had minor salivary gland involvement. Two patients had metastasis at the time of presentation. All patients underwent surgery. Radiotherapy was delivered to 16 patients and chemotherapy to 6 patients (concurrent, n = 3 and adjuvant, n = 3) and no adjuvant therapy was given to 2 patients. All patients were alive at a median follow-up of 3 years. No patient developed local or distant failure during the study duration. Conclusion: ACC has locally aggressive behavior. Radiotherapy adjuvant to surgery improves local control in locally advanced disease. Longer follow-up is mandatory in view of incidence of late metastasis.

Sharma K; Rathi A; Khurana N; Mukherji A; Kumar V; Singh K; Bahadur A

2010-01-01

176

High prevalence of Streptococcus pneumoniae in adenoids and nasopharynx in preschool children with recurrent upper respiratory tract infections in Poland--distribution of serotypes and drug resistance patterns.  

UK PubMed Central (United Kingdom)

BACKGROUND: Streptococcus pneumoniae is one of the major bacterial pathogens colonizing nasopharynx, and often causes upper respiratory tract infections in children. We investigated the prevalence of S. pneumoniae in nasopharynx and adenoid core in 57 children aged 2-5 years who underwent adenoidectomy for recurrent pharyngotonsillitis, and we determined serotypes and antibiotic resistance patterns of the isolated pneumococci. MATERIAL/METHODS: The nasopharyngeal specimens obtained before adenoidectomy and the adenoids after the surgery were cultured for pneumococci. All isolates were serotyped by means of Quellung reaction. Susceptibility to antibiotics was determined according to EUCAST recommendations. RESULTS: S. pneumoniae colonization was observed in 40 (70.2%) children. From 29 (50.9%) children S. pneumoniae was isolated both from nasopharynx and adenoid core; 2 or 3 different isolates were identified in 8 (14.0%) children. In 8 (14.0%) children pneumococci were obtained from adenoid core only and in 3 (5.3%) children from nasopharynx only. Among the isolates, 35.3% were susceptible to all tested antimicrobials and 45.1% had decreased susceptibility to penicillin. Multidrug resistance was present in 52.9% of the isolates. The most frequent was serotype 19F (25.5%). The prevalence of serotypes included in pneumococcal conjugate vaccines PCV10 and PCV13 was 51.0% and 62.7%, respectively. CONCLUSIONS: The adenoids, like the nasopharynx, can be regarded as a reservoir of pneumococci, including multidrug resistant strains, especially in children with indication for adenoidectomy due to recurrent respiratory tract infections refractory to antibiotic therapy. Good vaccine coverage among the isolated pneumococci confirmed the validity of the routine immunization by PCVs in young children.

Niedzielski A; Korona-Glowniak I; Malm A

2013-01-01

177

High prevalence of Streptococcus pneumoniae in adenoids and nasopharynx in preschool children with recurrent upper respiratory tract infections in Poland - distribution of serotypes and drug resistance patterns  

Science.gov (United States)

Background Streptococcus pneumoniae is one of the major bacterial pathogens colonizing nasopharynx, and often causes upper respiratory tract infections in children. We investigated the prevalence of S. pneumoniae in nasopharynx and adenoid core in 57 children aged 2–5 years who underwent adenoidectomy for recurrent pharyngotonsillitis, and we determined serotypes and antibiotic resistance patterns of the isolated pneumococci. Material/Methods The nasopharyngeal specimens obtained before adenoidectomy and the adenoids after the surgery were cultured for pneumococci. All isolates were serotyped by means of Quellung reaction. Susceptibility to antibiotics was determined according to EUCAST recommendations. Results S. pneumoniae colonization was observed in 40 (70.2%) children. From 29 (50.9%) children S. pneumoniae was isolated both from nasopharynx and adenoid core; 2 or 3 different isolates were identified in 8 (14.0%) children. In 8 (14.0%) children pneumococci were obtained from adenoid core only and in 3 (5.3%) children from nasopharynx only. Among the isolates, 35.3% were susceptible to all tested antimicrobials and 45.1% had decreased susceptibility to penicillin. Multidrug resistance was present in 52.9% of the isolates. The most frequent was serotype 19F (25.5%). The prevalence of serotypes included in pneumococcal conjugate vaccines PCV10 and PCV13 was 51.0% and 62.7%, respectively. Conclusions The adenoids, like the nasopharynx, can be regarded as a reservoir of pneumococci, including multidrug resistant strains, especially in children with indication for adenoidectomy due to recurrent respiratory tract infections refractory to antibiotic therapy. Good vaccine coverage among the isolated pneumococci confirmed the validity of the routine immunization by PCVs in young children.

Niedzielski, Artur; Korona-Glowniak, Izabela; Malm, Anna

2013-01-01

178

Sinonasal Tract and Nasopharyngeal Adenoid Cystic Carcinoma: A Clinicopathologic and Immunophenotypic Study of 86 Cases.  

UK PubMed Central (United Kingdom)

Primary sinonasal tract and nasopharyngeal adenoid cystic carcinomas (STACC) are uncommon tumors that are frequently misclassified, resulting in inappropriate clinical management. Eighty-six cases of STACC included 45 females and 41 males, aged 12-91 years (mean 54.4 years). Patients presented most frequently with obstructive symptoms (n = 54), followed by epistaxis (n = 23), auditory symptoms (n = 12), nerve symptoms (n = 11), nasal discharge (n = 11), and/or visual symptoms (n = 10), present for a mean of 18.2 months. The tumors involved the nasal cavity alone (n = 25), nasopharynx alone (n = 13), maxillary sinus alone (n = 4), or a combination of the nasal cavity and paranasal sinuses (n = 44), with a mean size of 3.7 cm. Patients presented equally between low and high stage disease: stage I and II (n = 42) or stage III and IV (n = 44) disease. Histologically, the tumors were invasive (bone: n = 66; neural: n = 47; lymphovascular: n = 33), composed of a variety of growth patterns, including cribriform (n = 33), tubular (n = 16), and solid (n = 9), although frequently a combination of these patterns was seen within a single tumor. Pleomorphism was mild with an intermediate N:C ratio in cells containing hyperchromatic nuclei. Reduplicated basement membrane and glycosaminoglycan material was commonly seen. Necrosis (n = 16) and atypical mitotic figures (n = 11) were infrequently present. Pleomorphic adenoma was present in 9 cases; de-differentiation was seen in two patients. Immunohistochemical studies showed positive reactions for pan-cytokeratin, CK7, CK5/6, CAM5.2, and EMA, with myoepithelial reactivity with SMA, p63, calponin, S100 protein and SMMHC. CD117, CEA, GFAP and p16 were variably present. CK20 and HR HPV were negative. STACC needs to be considered in the differential diagnosis of most sinonasal malignancies, particularly poorly differentiated carcinoma, olfactory neuroblastoma and pleomorphic adenoma. Surgery (n = 82), often accompanied by radiation therapy (n = 36), was generally employed. A majority of patients developed a recurrence (n = 52) 2-144 months after initial presentation. Overall mean follow-up was 19.4 years (range 0.4-37.5 years): 46 patients died with disease (mean 6.4 years); 5 were alive with disease (mean 5.4 years), and 35 patients were either alive or had died of unrelated causes (mean 16.3 years). ACC of the SNT is uncommon. Recurrences are common. The following parameters, when present, suggest an increased incidence of either recurrence or dying with disease: mixed site of involvement, high stage disease (stage IV), skull base involvement, tumor recurrence, a solid histology, perineural invasion, bone invasion, and lymphovascular invasion.

Thompson LD; Penner C; Ho NJ; Foss RD; Miettinen M; Wieneke JA; Moskaluk CA; Stelow EB

2013-09-01

179

Angiogenesis in triple-negative adenoid cystic carcinomas of the breast.  

UK PubMed Central (United Kingdom)

We compared microvascular density (MVD), lymph vessel density (LVD), and the expression of hypoxia pathway-associated proteins between primary triple-negative adenoid cystic carcinoma of the breast (TN-ACC) and grade-matched triple-negative breast carcinomas of no special type (TNBC). Twelve TN-ACC and 15 TNBC were investigated immunohistochemically for CD31, podoplanin (D2-40), von Hippel-Lindau protein (pVHL), and hypoxia-inducible factor-1alpha (HIF-1?) protein. All cases were lymph node negative (pN0). The study revealed a median MVD (CD31) of 34 vessels/mm(2) (mean ± SD, 41.33?±?6.5/mm(2)) in the TN-ACC subgroup and a median of 55 microvessels (mean ± SD, 54.9?±?6.3/mm(2)) in the TNBC subgroup. The median LVD (D2-40) was 10.5/mm(2) (mean ± SD, 11.9?±?1.5/mm(2)) in the TN-ACC subgroup and 15.0/mm(2) (mean ± SD, 16.9?±?2.5/mm(2)) lymph vessels in the TNBC subgroup. The differences were not statistically significant (P?=?0.93, P?=?0.67, respectively). pVHL was detectable in all TN-ACCs whereas two cases of TNBC had less than 5% of the positive cells. HIF-1? protein expression was significantly higher in the tumor cell population than in adjacent normal cells in both subgroups (P?=?0.009 for TNBC and P?=?0.028 for TN-ACC, respectively), but there was no significant difference between the two tumor groups. Up-regulation of the hypoxia-induced signaling is seen in both TN-ACC and grade-matched TNBC. Despite its perceived low malignant potential, TN-ACC of the breast does not differ in the number of blood and lymphatic vessels in comparison with the grade-matched TNBC. The reported biologic differences between TN-ACC and TNBC do not appear to result from neoangiogenesis.

Vranic S; Frkovic-Grazio S; Bilalovic N; Gatalica Z

2011-10-01

180

Diagnostic SOX10 gene signatures in salivary adenoid cystic and breast basal-like carcinomas.  

UK PubMed Central (United Kingdom)

BACKGROUND: Salivary adenoid cystic carcinoma (ACC) is an insidious slow-growing cancer with the propensity to recur and metastasise to distant sites. Basal-like breast carcinoma (BBC) is a molecular subtype that constitutes 15-20% of breast cancers, shares histological similarities and basal cell markers with ACC, lacks expression of ER (oestrogen receptor), PR (progesterone receptor), and HER2 (human epidermal growth factor receptor 2), and, similar to ACC, metastasises predominantly to the lung and brain. Both cancers lack targeted therapies owing to poor understanding of their molecular drivers. METHODS: Gene expression profiling, immunohistochemical staining, western blot, RT-PCR, and in silico analysis of massive cancer data sets were used to identify novel markers and potential therapeutic targets for ACC and BBC. For the detection and comparison of gene signatures, we performed co-expression analysis using a recently developed web-based multi-experiment matrix tool for visualisation and rank aggregation. RESULTS: In ACC and BBC we identified characteristic and overlapping SOX10 gene signatures that contained a large set of novel potential molecular markers. SOX10 was validated as a sensitive diagnostic marker for both cancers and its expression was linked to normal and malignant myoepithelial/basal cells. In ACC, BBC, and melanoma (MEL), SOX10 expression strongly co-segregated with the expression of ROPN1B, GPM6B, COL9A3, and MIA. In ACC and breast cancers, SOX10 expression negatively correlated with FOXA1, a cell identity marker and major regulator of the luminal breast subtype. Diagnostic significance of several conserved elements of the SOX10 signature (MIA, TRIM2, ROPN1, and ROPN1B) was validated on BBC cell lines. CONCLUSION: SOX10 expression in ACC and BBC appears to be a part of a highly coordinated transcriptional programme characteristic for cancers with basal/myoepithelial features. Comparison between ACC/BBC and other cancers, such as neuroblastomaand MEL, reveals potential molecular markers specific for these cancers that are likely linked to their cell identity. SOX10 as a novel diagnostic marker for ACC and BBC provides important molecular insight into their molecular aetiology and cell origin. Given that SOX10 was recently described as a principal driver of MEL, identification of conserved elements of the SOX10 signatures may help in better understanding of SOX10-related signalling and development of novel diagnostic and therapeutic tools.

Ivanov SV; Panaccione A; Nonaka D; Prasad ML; Boyd KL; Brown B; Guo Y; Sewell A; Yarbrough WG

2013-07-01

 
 
 
 
181

Experiences in combined treatment of cystic adenoid carcinomas by hyperthermia and radiotherapy in comparison with conventional treatment  

Energy Technology Data Exchange (ETDEWEB)

158 patients with advanced malignancies of the head and neck area were treated by a combined hyperthermia/radiotherapy since 1972. 16 were adenoid cystic carcinoma (ACC). Their treatment results are compared with 28 ACC after radiotherapy alone. All 16 patients with hyperthermia achieved a complete remission. CR in 28 ACC-patients with hyperthermia-treated squamous cell carcinomas had a comparatively low CR-rate of 49%. Five-year-survival on the other hand was 50% for ACC after hyperthermia, 57% after a planned postoperative radiation without hyperthermia and 37,5% after a radiotherapy alone in cases of inoperability. The combination of hyperthermia and radiotherapy is indicated in cases of advanced inoperable ACC and leads to a high percentage of local tumour control.

Weischedel, U.; Wieland, C.

1987-11-01

182

An unusual presentation of adenoid cystic carcinoma of the minor salivary glands with cranial nerve palsy: a case study  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background Adenoid Cystic Carcinoma (ACC) is a rare tumor entity and comprises about 1% of all malignant tumor of the oral and maxillofacial region. It is slow growing but a highly invasive cancer with a high recurrence rate. Intracranial ACC is even more infrequent and could be primary or secondary occurring either by direct invasion, hematogenous spread, or perineural spread. We report the first case of the 5th and 6th nerve palsy due to cavernous sinus invasion by adenoid cystic carcinoma. Case presentation A 49-year-old African American female presented to the emergency room complaining of severe right-sided headache, photophobia, dizziness and nausea, with diplopia. The patient had a 14 year history migraine headaches, hypertension, and mild intermittent asthma. Physical examination revealed right lateral rectus muscle palsy with esotropia. There was numbness in all three divisions of the right trigeminal nerve. Motor and sensory examination of extremities was normal. An MRI of the brain/brain stem was obtained which showed a large mass in the clivus extending to involve the nasopharynx, pterygoid plate, sphenoid and right cavernous sinuses. Biopsy showed an ACC tumor with a cribriform pattern of the minor salivary glands. The patient underwent total gross surgical resection and radiation therapy. Conclusion This is a case of ACC of the minor salivary glands with intracranial invasion. The patient had long history of headaches which changed in character during the past year, and symptoms of acute 5th and 6th cranial nerve involvement. Our unique case demonstrates direct invasion of cavernous sinus and could explain the 5th and 6th cranial nerve involvement as histopathology revealed no perineural invasion.

Abdul-Hussein Amal; Morris Pierre A; Markova Tsveti

2007-01-01

183

Diagnostic accuracy of nasopharyngeal swabs in detecting biofilm-producing bacteria in chronic adenoiditis: a preliminary study.  

UK PubMed Central (United Kingdom)

OBJECTIVES: Biofilms are organized bacterial communities that are playing an increasing role in otolaryngological diseases such as chronic or recurrent middle ear otitis and adenotonsillitis. Various cultural techniques are available to detect biofilm-producing bacteria (BPB), but microbiological analysis of bioptic staining is the reference diagnostic procedure. To our knowledge, the accuracy of nasopharyngeal swabs in diagnosing BPB has never been assessed. STUDY DESIGN: A prospective study of diagnostic accuracy. SETTING: Outpatient clinics of the Departments of Specialist Surgical Sciences and Maternal and Pediatric Sciences, University of Milan, Italy. SUBJECTS AND METHODS: Forty-two pediatric subjects with chronic adenoiditis (aged 4-18 years) underwent adenoidectomy, during which multiple transoral nasopharyngeal swabs and adenoidal biopsies were performed. BPB were detected by spectrophotometry, and the accuracy of detecting BPB in nasopharyngeal swabs was compared with that of biopsy. RESULTS: BPB were detected in 73.8% of the nasopharyngeal swabs and in 69.1% of the biopsies. The sensitivity and specificity of the nasopharyngeal swabs were, respectively, 75.9% (95% confidence interval [CI], 60.3%-91.4%) and 30.8% (95% CI, 5.7%-55.9%); positive and negative predictive values were, respectively, 71.0% (95% CI, 55.0%-86.9%) and 36.4% (95% CI, 7.9%-64.8%); and the area under the receiver-operating characteristic curve was 0.5 (95% CI, 0.4-0.7). CONCLUSIONS: In comparison with biopsy, nasopharyngeal swabs seem to be inaccurate in detecting BPB and should be cautiously used in clinical practice. As these preliminary findings may have been due to the well-known resistance of biofilm to mechanical injuries (such as swab rubbing) or the small study population, they need to be confirmed in larger patient series.

Torretta S; Drago L; Marchisio P; Mattina R; Clemente IA; Pignataro L

2011-05-01

184

Endoscopic-assisted microscopic decompression of adenoid cystic carcinoma of paranasal sinus extending to the sella: A case report and review of literature  

Directory of Open Access Journals (Sweden)

Full Text Available Technological development in neuroendoscopy has lead to an expansion of its applications. The dimensions of a microsurgical approach to the brain can greatly be enlarged with the use of endoscope, making it possible to look behind structures and around corners. We performed an endoscopic assisted microsurgical decompression of an adenoid cystic carcinoma of paranasal sinus with intracranial sellar extension with good results.

Tripathy Pradipta; Dewan Yashbir

2009-01-01

185

Adenoid cystic carcinoma of the head and neck treated by surgery with or without postoperative radiation therapy: Prognostic features of recurrence  

International Nuclear Information System (INIS)

Purpose: This study sought to review a single-institution experience with the management of adenoid cystic carcinoma of the head and neck. Methods and Materials: Between 1960 and 2004, 140 patients with adenoid cystic carcinoma of the head and neck were treated with definitive surgery. Ninety patients (64%) received postoperative radiation to a median dose of 64 Gy (range, 54-71 Gy). Distribution of T stage was: 26% T1, 28% T2, 20% T3, and 26% T4. Seventy-eight patients (56%) had microscopically positive margins. Median follow-up was 66 months (range, 7-267 months). Results: The 5- and 10-year rate estimates of local control were 88% and 77%, respectively. A Cox proportional hazards model identified T4 disease (p = 0.0001), perineural invasion (p = 0.008), omission of postoperative radiation (p = 0.007), and major nerve involvement (p = 0.02) as independent predictors of local recurrence. Radiation dose lower than 60 Gy (p = 0.0004), T4 disease (p 0.005), and major nerve involvement (p = 0.02) were predictors of local recurrence among those treated with surgery and postoperative radiation. The 10-year overall survival and distant metastasis-free survival were 64% and 66%, respectively. Conclusion: Combined-modality therapy with surgery followed by radiation to doses in excess of 60 Gy should be considered the standard of care for adenoid cystic carcinoma of the head and neck.

186

Increased numbers of P63-positive/CD117-positive cells in advanced adenoid cystic carcinoma give a poorer prognosis  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Objectives This study consisted of two parts. One part was to analyze the survival rates of adenoid cystic carcinoma (ACC) in Chinese and explain the difference between our data and the literature. The other was to analyze the relationship between the expression of CD117 and the histological grade and the prognosis. Methods A retrospective study of 80 ACC patients was performed. Clinical data were collected, and p63, CD117 were detected by immunohistochemical staining. Results Eighty patients received follow-ups 3 to 216?months after initial diagnosis. ACC occurred in the lacrimal gland (26.3%, n?=?21), nasal cavity and parasinus (33.8%, n?=?27) and other sites (40.0%, n?=?33). The 5-year and 10-year survival rates were 66.41% and 10.16%, respectively. Over expression of CD117 was detected in p63-negative cells in 94.3% of cases and in p63-positive cells in 45.8%. The expression of CD117 in p63-positive cells was significantly associated with the histological grade (P Conclusions ACC had a good 5-year survival but poor 10-year survival in Chinese, which differed from the occidental data. More p63+/CD117+ cells were associated with a higher histological grade and poorer outcome. Virtual slides The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1701457278762097

Zhou Quan; Chang Hong; Zhang Hongkai; Han Yiding; Liu Honggang

2012-01-01

187

Analysis of failure in patients with adenoid cystic carcinoma of the head and neck an international collaborative study.  

Science.gov (United States)

BACKGROUND Adenoid cystic carcinoma (ACC) is a locally aggressive tumor with a high prevalence of distant metastases. The current study aimed to identify independent predictors of outcome and to characterize the patterns of failure. METHODS: An international retrospective review of 489 ACC patients treated between 1985 and 2011 in 9 cancer centers worldwide. RESULTS: Five-year overall-survival (OS), disease-specific survival(DSS) and disease-free survival (DFS) were 76%, 80% and 68%, respectively. Independent predictors of OS and DSS were: age, site, N classification and presence of distant metastases(DM). N stage, age and bone invasion were associated with DFS on multivariate analysis. Age, tumor site, orbital invasion and N stage were independent predictors of DM. CONCLUSION: The clinical course of ACC is slow but persistent. Paranasal sinus origin is associated with the lowest distant metastasis rate but with the poorest outcome. These prognostic estimates should be considered when tailoring treatment for patients with ACC. Head Neck, 2013. PMID:23784851

Amit, Moran; Binenbaum, Yoav; Sharma, Kanika; Naomi D, Ramer; Ilana, Ramer; Abib, Agbetoba; Miles, Brett; Yang, Xinjie; Lei, Delin; Kristine, Bjoerndal; Christian, Godballe; Thomas, Mücke; Klaus-Dietrich, Wolff; Fliss, Dan; Eckardt, André M; Chiara, Copelli; Sesenna, Enrico; Frank, Palmer; Patel, Snehal; Gil, Ziv

2013-06-19

188

Expression and significance of Cyr61 in distant metastasis cells of human primary salivary adenoid cystic carcinoma.  

UK PubMed Central (United Kingdom)

OBJECTIVE: The objective of this study was to examine the expression of cysteine-rich protein 61 (Cyr61) in the distant metastatic tumor cells of human primary salivary adenoid cystic carcinoma (SACC) and its relationship with tumor angiogensis and metastasis. STUDY DESIGN: The experimental group comprised 35 paraffin-embedded tumor specimens of distant metastasis from primary SACC, with their corresponding primary tumor tissues and matched normal salivary gland tissues used as the control groups. Immunohistochemical staining was used to detect the expression of Cyr61 and vascular endothelial growth factor in the experimental and control groups. Vascular endothelial cells were highlighted by the anti-CD34 antibody, and the Weidner method was used to quantify microvessel density (MVD). RESULTS: Cyr61 was overexpressed in distant metastatic tumor cells of primary SACC. Positive expression of Cyr61 and vascular endothelial growth factor (VEGF) progressively increased in normal salivary gland tissues, primary tumor tissues, and tumor tissues of distant metastasis (P < .05). Compared with primary tumor tissues, Cyr61 expression and VEGF expression showed significant increase in tumor tissues of distant metastasis (P < .05). Cyr61 expression significantly correlated with VEGF expression and MVD (P < .05). CONCLUSIONS: Cyr61 appeared to have a significant association with tumor angiogenesis and metastasis in SACC and may be an important target in tumor antiangiogenesis therapy.

Tang QL; Chen WL; Tan XY; Li HG; Yuan XP; Fan S; Wen B; Song Y

2011-08-01

189

EXPRESSION OF MATRIX METALLOPROTEINASE MMP-2 AND ITS TISSUE INHIBITOR TIMP-2 IN INTRAORAL PLEOMORPHIC ADENOMA AND ADENOID CYSTIC CARCINOMA  

Directory of Open Access Journals (Sweden)

Full Text Available Matrix metalloproteinases (MMPs) are proteolytic enzymes that are capable of degrading different substrates within extracellular matrix (ECM), and are believed to be crucial for tumor invasion and metastasis. Tissue inhibitors of MMP (TIMPs) can inhibit the action of MMPs The aim of this study was to analyze protein expression of MMP-2 and TIMP-2 in intraoral pleomorphic adenoma (PLA) and adenoid cystic carcinoma (ACC). A total of 35 formalin-fixed paraffin-embedded specimens comprising 19 PLA and 16 ACC were utilized in this study. A standard immunohistochemical technique was used to determine the expression levels of MMP-2 and TIMP-2 proteins. Sections were assessed semi quantitatively .Staining was scored as 0 ( 50% positive tumor cells). For statistical analysis, tumors were divided into two groups, low expressors ( 0-1+) and high expressors (2-3+). PLA showed higher TIMP-2 expression than ACC (p<0.05). No significant difference was observed between PLA and ACC regarding MMP-2 expression. MMP-2 and TIMP-2 expressed mainly in the cytoplasm of epithelial/ myoepithelial components of PLA and neoplastic epithelial cells of ACC. Myoepithelial cells may be the primary source of gelatinases in PLA and the down regulation of TIMP-2 expression in ACC might be responsible for metastasis and recurrence. The ratio value of MMP-2/TIMP-2 is valuable parameter to demonstrate the ECM degradation/ deposition imbalance.

Natheer Hashim AL-Rawi; Muthanna Al-Samarai; Sausan Al-Kawas; Ahlam H. Majeed

2011-01-01

190

Signet-ring cell change in adenoid cystic carcinoma: a clinicopathological and immunohistochemical study of four cases.  

UK PubMed Central (United Kingdom)

AIMS: Signet-ring cell (SRC) change has not been reported in adenoid cystic carcinoma (ACC). The aim of this study was to describe the clinicopathological and immunohistochemical findings in four cases of ACC with SRCs (ACC-SRC), in which the relative proportion of the SRC component ranged from 25% to 50%. METHODS AND RESULTS: The median age was 58 years (range: 48-81 years), and all patients were women. The involved sites were sinonasal, lip, and submandibular. Two patients developed lung metastasis, and one died of disease 63 months after tumour resection. Neither mucinous nor lipid substances were detected in the SRCs. These showed positive staining for AE1/AE3, cytokeratin 14, and epithelial membrane antigen, which highlighted the intracytoplasmic vacuole borders. The SRC nests were surrounded by myoepithelial cells positive for ?-smooth muscle actin and p63. The SRCs showed similar p53 positivity but lower Ki67 and mitotic indices than the conventional component. SRCs were c-Myb-negative. Ultrastructural examination revealed that the intracytoplasmic vacuoles were lumina lined by microvilli. CONCLUSIONS: ACC-SRC is a non-mucin-producing and non-lipid-producing phenomenon, possibly related to disturbed differentiation of ductal/luminal cells. This cellular modification in ACC apparently does not change the biological behaviour of the tumour, but it may cause significant diagnostic problems, particularly in incisional biopsies.

Altemani A; Costa AF; Montalli VA; Mosqueda-Taylor A; Paes de Almeida O; León JE; Hermsen M

2013-03-01

191

RadioImmunotherapy for adenoid cystic carcinoma: a single-institution series of combined treatment with cetuximab  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background Local control in adjuvant/definitive RT of adenoid cystic carcinoma (ACC) is largely dose-dependent. However, some clinical situations do not allow application of tumouricidal doses (i.e. re-irradiation) hence radiation sensitization by exploitation of high endothelial growth factor receptor (EGFR)-expression in ACC seems beneficial. This is a single-institution experience of combined radioimmunotherapy (RIT) with the EGFR-inhibitor cetuximab. Methods Between 2006 and 2010, 9 pts received RIT for advanced/recurrent ACC, 5/9 pts as re-irradiation. Baseline characteristics as well as treatment parameters were retrieved to evaluate efficacy and toxicity of the combination regimen were evaluated. Control rates (local/distant) and overall survival were calculated using Kaplan-Meier estimation. Results Median dose was 65 Gy, pts received a median of 6 cycles cetuximab. RIT was tolerated well with only one °III mucositis/dysphagia. Overall response/remission rates were high (77,8%); 2-year estimate of local control was 80% hence reaching local control levels comparable to high-dose RT. Progression-free survival (PFS) at 2 years and median overall survival were only 62,5% and 22,2 mo respectively. Conclusion While local control and treatment response in RIT seems promising, PFS and overall survival are still hampered by distant failure. The potential benefit of RIT with cetuximab warrants exploration in a prospective controlled clinical trial.

Jensen Alexandra D; Krauss Jürgen; Weichert Wilko; Debus Jürgen; Münter Marc W

2010-01-01

192

Increased numbers of P63-positive/CD117-positive cells in advanced adenoid cystic carcinoma give a poorer prognosis.  

UK PubMed Central (United Kingdom)

OBJECTIVES: This study consisted of two parts. One part was to analyze the survival rates of adenoid cystic carcinoma (ACC) in Chinese and explain the difference between our data and the literature. The other was to analyze the relationship between the expression of CD117 and the histological grade and the prognosis. METHODS: A retrospective study of 80 ACC patients was performed. Clinical data were collected, and p63, CD117 were detected by immunohistochemical staining. RESULTS: Eighty patients received follow-ups 3 to 216?months after initial diagnosis. ACC occurred in the lacrimal gland (26.3%, n?=?21), nasal cavity and parasinus (33.8%, n?=?27) and other sites (40.0%, n?=?33). The 5-year and 10-year survival rates were 66.41% and 10.16%, respectively. Over expression of CD117 was detected in p63-negative cells in 94.3% of cases and in p63-positive cells in 45.8%. The expression of CD117 in p63-positive cells was significantly associated with the histological grade (P<0.001) and prognosis (P?=?0.037) in patients in the advanced stage. CONCLUSIONS: ACC had a good 5-year survival but poor 10-year survival in Chinese, which differed from the occidental data. More p63+/CD117+ cells were associated with a higher histological grade and poorer outcome. VIRTUAL SLIDES: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1701457278762097.

Zhou Q; Chang H; Zhang H; Han Y; Liu H

2012-01-01

193

125I brachytherapy alone for recurrent or locally advanced adenoid cystic carcinoma of the oral and maxillofacial region.  

UK PubMed Central (United Kingdom)

BACKGROUND AND PURPOSE: This retrospective study was to evaluate the local control and survival of (125)I brachytherapy for recurrent and/or locally advanced adenoid cystic carcinoma (ACC) of the oral and maxillofacial region. PATIENTS AND METHODS: A total of 38 patients with recurrent and/or locally advanced ACC of the oral and maxillofacial region received (125)I brachytherapy alone from 2001-2010. Twenty-nine were recurrent cases following previous surgery and radiation therapy. The other 9 cases involved primary tumors. Overall, 12 tumors were located in the major salivary glands, 12 in the minor salivary glands, and 14 in the paranasal region, the nasal cavity or the skull base. The prescribed dose was 100-160 Gy. RESULTS: Patients were followed for 12-122 months (median 51 months). The 2-, 5-, and 10-year local tumor control rates were 86.3, 59, and 31.5?%, respectively. The 2-, 5-, and 10-year overall survival rates were 92.1, 65 and 34.1?%, respectively. Tumors >?6 cm had significantly lower local control and survival rates. No severe complications were observed during follow-up. CONCLUSION: (125)I brachytherapy is a feasible and effective modality for the treatment of locally advanced unresectable or recurrent ACC.

Huang MW; Zheng L; Liu SM; Shi Y; Zhang J; Yu GY; Zhang JG

2013-06-01

194

{sup 125}I brachytherapy alone for recurrent or locally advanced adenoid cystic carcinoma of the oral and maxillofacial region  

Energy Technology Data Exchange (ETDEWEB)

Background and purpose: This retrospective study was to evaluate the local control and survival of {sup 125}I brachytherapy for recurrent and/or locally advanced adenoid cystic carcinoma (ACC) of the oral and maxillofacial region. Patients and methods: A total of 38 patients with recurrent and/or locally advanced ACC of the oral and maxillofacial region received {sup 125}I brachytherapy alone from 2001-2010. Twenty-nine were recurrent cases following previous surgery and radiation therapy. The other 9 cases involved primary tumors. Overall, 12 tumors were located in the major salivary glands, 12 in the minor salivary glands, and 14 in the paranasal region, the nasal cavity or the skull base. The prescribed dose was 100-160 Gy. Results: Patients were followed for 12-122 months (median 51 months). The 2-, 5-, and 10-year local tumor control rates were 86.3, 59, and 31.5 %, respectively. The 2-, 5-, and 10-year overall survival rates were 92.1, 65 and 34.1 %, respectively. Tumors > 6 cm had significantly lower local control and survival rates. No severe complications were observed during follow-up. Conclusion: {sup 125}I brachytherapy is a feasible and effective modality for the treatment of locally advanced unresectable or recurrent ACC. (orig.)

Huang, M.W.; Zheng, L.; Liu, S.M.; Shi, Y.; Zhang, J.; Yu, G.Y.; Zhang, J.G. [Peking Univ. School and Hospital of Stomatology, Beijing (China). Dept. of Oral and Maxillofacial Surgery

2013-06-15

195

125I brachytherapy alone for recurrent or locally advanced adenoid cystic carcinoma of the oral and maxillofacial region  

International Nuclear Information System (INIS)

[en] Background and purpose: This retrospective study was to evaluate the local control and survival of 125I brachytherapy for recurrent and/or locally advanced adenoid cystic carcinoma (ACC) of the oral and maxillofacial region. Patients and methods: A total of 38 patients with recurrent and/or locally advanced ACC of the oral and maxillofacial region received 125I brachytherapy alone from 2001-2010. Twenty-nine were recurrent cases following previous surgery and radiation therapy. The other 9 cases involved primary tumors. Overall, 12 tumors were located in the major salivary glands, 12 in the minor salivary glands, and 14 in the paranasal region, the nasal cavity or the skull base. The prescribed dose was 100-160 Gy. Results: Patients were followed for 12-122 months (median 51 months). The 2-, 5-, and 10-year local tumor control rates were 86.3, 59, and 31.5 %, respectively. The 2-, 5-, and 10-year overall survival rates were 92.1, 65 and 34.1 %, respectively. Tumors > 6 cm had significantly lower local control and survival rates. No severe complications were observed during follow-up. Conclusion: 125I brachytherapy is a feasible and effective modality for the treatment of locally advanced unresectable or recurrent ACC. (orig.)

2013-01-01

196

Antitumor effects of telomerase-specific replication-selective oncolytic viruses for adenoid cystic carcinoma cell lines.  

Science.gov (United States)

We evaluated the antitumor effect of a telomerase-specific replication-selective adenovirus (Telomelysin, OBP-301) for adenoid cystic carcinoma (ACC) in vitro and in vivo. Adenovirus E1 gene expression was controlled by human telomerase reverse transcription (hTERT). Infection of ACC cells by OBP-301 induced high E1A mRNA expression and subsequent oncolytic cell death in a dose-dependent manner. Using OBP-401 (TelomeScan), a genetically engineered adenovirus that carries the GFP gene under the control of the cytomegalovirus (CMV) promoter at the deleted E3 region of OBP-301, ACC cells expressed bright GFP fluorescence as early as 12 h after OBP-401 infection. The fluorescence intensity gradually increased in a time-dependent manner, followed by rapid cell death due to the cytopathic effect of OBP-401, as evidenced by the floating, highly light-refractive cells using phase-contrast microscopy. Effects of intratumorally injected OBP-401 against established Acc2 xenograft tumors were seen in BALB/c nu/nu mice. The levels of GFP expression following ex vivo infection of OBP-401 may be of value as a positive predictive marker for the outcome of telomerase-specific virotherapy. Our data clearly indicated that telomerase-specific oncolytic adenoviruses have significant therapeutic potential against human ACC in vitro and in vivo. These results suggest that treatment with OBP-301 and OBP-401 may improve the quality of life of oral cancer patients. PMID:24065118

Sato, Daisuke; Kurihara, Yuji; Kondo, Seiji; Shirota, Tatsuo; Urata, Yasuo; Fujiwara, Toshiyoshi; Shintani, Satoru

2013-09-19

197

Salivary adenoid cystic carcinoma with an early phase of high-grade transformation: case report with an immunohistochemical analysis  

Science.gov (United States)

Background The early phase of salivary gland carcinomas with high-grade transformation (HGT) is extremely rare. We reported one case of adenoid cystic carcinoma (AdCC) with early HGT, herein. Case presentation The patient was a 27-year-old Japanese woman who suffered from swelling of the left parotid region. Most of this tumor consisted of typical AdCC histology, whereas the central area of this tumor was composed of solid growth component by atypical cells with clear cytoplasm and marked nuclear atypia. Immunohistochemically, this area was strongly and diffusely positive for epithelial membrane antigen, p53, p16, Her-2, cyclin A and cyclin B1. The Ki-67 labeling index of this area was high, entirely different from that of AdCC area. Conclusion Overall, this area was an early phase of AdCC-HGT. This case is the second case of early AdCC-HGT. We discuss the development of salivary gland carcinoma with HGT. Virtual Slides http://www.diagnosticpatology.diagnomx.eu/vx/1598278104895730

2013-01-01

198

Analysis of failure in patients with adenoid cystic carcinoma of the head and neck an international collaborative study  

DEFF Research Database (Denmark)

BACKGROUND Adenoid cystic carcinoma (ACC) is a locally aggressive tumor with a high prevalence of distant metastases. The current study aimed to identify independent predictors of outcome and to characterize the patterns of failure. METHODS: An international retrospective review of 489 ACC patients treated between 1985 and 2011 in 9 cancer centers worldwide. RESULTS: Five-year overall-survival (OS), disease-specific survival(DSS) and disease-free survival (DFS) were 76%, 80% and 68%, respectively. Independent predictors of OS and DSS were: age, site, N classification and presence of distant metastases(DM). N stage, age and bone invasion were associated with DFS on multivariate analysis. Age, tumor site, orbital invasion and N stage were independent predictors of DM. CONCLUSION: The clinical course of ACC is slow but persistent. Paranasal sinus origin is associated with the lowest distant metastasis rate but with the poorest outcome. These prognostic estimates should be considered when tailoring treatment for patients with ACC. Head Neck, 2013.

Amit, Moran; Binenbaum, Yoav

2013-01-01

199

Nef from SIV(mac239) decreases proliferation and migration of adenoid-cystic carcinoma cells and inhibits angiogenesis.  

UK PubMed Central (United Kingdom)

The HIV/SIV accessory protein Nef is known to down-modulate cell surface receptors that are required for virus entry such as CD4, CCR5 and CXCR4 to block lethal viral superinfection of the infected cell. The chemokine receptor CXCR4 also plays an important role in promoting cell proliferation, metastasis and tumor angiogenesis. Therefore it was of interest to evaluate if Nef can down-regulate CXCR4 in tumor cells since this could affect these critical prognostic parameters. The CXCR4-expressing cell line ACC3 that was derived from a salivary gland adenoid cystic carcinoma (ACC) of the head and neck was transfected with Nef from SIV(mac239) and cell surface expression of the receptor was monitored by FACS analysis. Real time proliferation of cells was measured with the xCELLigence system (Roche, Mannheim, Germany). Cell migration was detected by an in vitro scratch assay. Similarly, COS-7 cells were co-transfected with CXCR4 and Nef and were treated as described for ACC3. In vitro tube formation was deployed to assess the effect of Nef on angiogenesis. siRNA was used for CXCR4 knockdown. Cell surface down-modulation of endogenous CXCR4 could be observed in ACC3 cells after Nef-transfection as well as in COS-7 cells after co-transfection of CXCR4 and Nef. Proliferation as well as migration of Nef-transfected ACC3 tumor cells appeared significantly reduced. In vitro tube formation was significantly lowered after Nef-transfection or CXCR4 knockdown with siRNA. SIV-Nef could serve as an interesting tool to study the biologic behavior of CXCR4-expressing tumors such as ACC. Deploying SIV-Nef thereby could help in the discovery of new therapeutic approaches for the treatment of ACC and other CXCR4-expressing tumors.

Cai C; Rodepeter FR; Rossmann A; Teymoortash A; Lee JS; Quint K; Di Fazio P; Ocker M; Werner JA; Mandic R

2011-09-01

200

Nef from SIV(mac239) decreases proliferation and migration of adenoid-cystic carcinoma cells and inhibits angiogenesis.  

Science.gov (United States)

The HIV/SIV accessory protein Nef is known to down-modulate cell surface receptors that are required for virus entry such as CD4, CCR5 and CXCR4 to block lethal viral superinfection of the infected cell. The chemokine receptor CXCR4 also plays an important role in promoting cell proliferation, metastasis and tumor angiogenesis. Therefore it was of interest to evaluate if Nef can down-regulate CXCR4 in tumor cells since this could affect these critical prognostic parameters. The CXCR4-expressing cell line ACC3 that was derived from a salivary gland adenoid cystic carcinoma (ACC) of the head and neck was transfected with Nef from SIV(mac239) and cell surface expression of the receptor was monitored by FACS analysis. Real time proliferation of cells was measured with the xCELLigence system (Roche, Mannheim, Germany). Cell migration was detected by an in vitro scratch assay. Similarly, COS-7 cells were co-transfected with CXCR4 and Nef and were treated as described for ACC3. In vitro tube formation was deployed to assess the effect of Nef on angiogenesis. siRNA was used for CXCR4 knockdown. Cell surface down-modulation of endogenous CXCR4 could be observed in ACC3 cells after Nef-transfection as well as in COS-7 cells after co-transfection of CXCR4 and Nef. Proliferation as well as migration of Nef-transfected ACC3 tumor cells appeared significantly reduced. In vitro tube formation was significantly lowered after Nef-transfection or CXCR4 knockdown with siRNA. SIV-Nef could serve as an interesting tool to study the biologic behavior of CXCR4-expressing tumors such as ACC. Deploying SIV-Nef thereby could help in the discovery of new therapeutic approaches for the treatment of ACC and other CXCR4-expressing tumors. PMID:21763177

Cai, Chengzhong; Rodepeter, Fiona R; Rossmann, Annette; Teymoortash, Afshin; Lee, Jin-Seok; Quint, Karl; Di Fazio, Pietro; Ocker, Matthias; Werner, Jochen A; Mandic, Robert

2011-07-16

 
 
 
 
201

The Role of Radiation Therapy in the Treatment of Adenoid Cystic Carcinoma of the Head and Neck  

International Nuclear Information System (INIS)

Forty eight patients with adenoid cystic carcinoma(ACC) in the head and beck treated between 1979 and 1990 were reviewed according to treatment modalities and clinical courses. The common site of origin was minor salivary gland (69%), mostly had palate and maxillary sinus. 11 patients received radiation therapy(RT) alone and 37 patients received combined surgery and radiation therapy. The follow-up period of the survivors ranged from 4 to 118 months (median 49.5 months). The 5 year local control rate was 69.3%, 67.3% and 83.9% in RT alone, conservative operation(OP)+RT and radical OP+RT group, respectively(p>0.05). The control of local disease was best achieved with radical OP+RT. In postoperative RT, high dose (?60 Gy) and generous field size (>64cm2) yielded a better local control rate. Actuarial overall survival rate was 79.0%, at 5 years and 19.2% at 10 years. Distant metastases (DM) developed in 40% of patients, mostly in the lung. Disease-free(NED) survival rate was 45.8%, at 5 years and significant differences did not exist according to primary sites and treatment options. Survival rate after the onset of DM was 19.5% at 5 years. Occurrence of DM tends to lower survival significantly. In an effort to find the role of RT in the treatment of ACC, our data suggest that a well-planned postoperative RT employing a high dose and generous field size can produce high local control rate and remaining urgent problem of distant metastasis demands more effective chemotherapy for the purpose of improving survival of ACC patients.

202

Primary adenoid cystic carcinoma of the tracheobronchial tree: A decade-long experience at a health centre in Mexico.  

UK PubMed Central (United Kingdom)

BACKGROUND: Mexico's National Institute of Respiratory Diseases (NIRD) is a third-level national reference center. Primary adenoid cystic carcinoma (PACC) is an uncommon neoplastic disorder; hence improvements in the description of this disease are needed. MATERIALS AND METHODS: This is a retrospective clinical study based on all consecutive patients with pathological diagnoses of PACC seen at the NIRD between January 1, 2000 and December 31, 2009. RESULTS: We identified 9 cases of PACC (67% female) out of a total of 2,634 patients with lung cancer seen during the period analyzed. The mean age of those 9 patients was 41 years (IQR 36-57), and the frequency of PACC at our center was 0.3%. It is important to note that 67% of those patients had a history of smoking and that 6 of the 9 had the antecedent of previous exposure to biomass fuel smoke. Baseline arterial blood gas analyses revealed a median of 61 mmHg for pO(2) and 28.5 mmHg for pCO(2). Median FVC was 78%, while FEV(1) was 77% with an FEV(1) /FVC ratio of 78. Death occurred in 56% of cases, and the median survival time was 17 months (IQR 6-26) after the initial diagnosis. CONCLUSIONS: The frequency of tracheobronchial PACC among patients with lung cancer was similar to that previously reported (0.3%). According to our results, lung function has no specific phenotype in this disease; however, some abnormalities could be related to potential risk factors such as tobacco use and exposure to biomass fuel smoke.

Cortés-Télles A; Mendoza-Posada D

2012-10-01

203

A 20-Year Retrospective Study of Salivary Gland Adenoid Cystic Carcinoma in a Sample of Iranian Patients  

Directory of Open Access Journals (Sweden)

Full Text Available Objective: The aim of the present study was to investigate the demographic and pathological aspects of adenoid cystic carcinomas (ACC) in an Iranian sample based on a 20-year archive review.Materials and Methods: In this descriptive study, tumors of the head and neck registered between 1980 and 2000 were evaluated and cases of ACC were selected. Patients’ medical records and pathology reports were reviewed. Variables such as age, sex, duration of disease,symptoms, site of tumor involvement and tumor diameter as well as pathologic features were recorded. Analysis was performed using chi-square and t-tests; P<0.05 was considered as the level of significance.Results: ACC was the most common malignant tumor followed by mucoepidermoid carcinoma and adenocarcinoma NOS. A total of 120 ACCs were found, of which 50.8% occurred in females and 49.2% in males. Patients’ ages ranged from 5 to 90 with a mean of 49.2 (SD=15.9) years. In 60.9% of cases, minor salivary glands were involved and the palate was the most common site. The greatest tumor diameter was between 2-15cm with a mean of 4.6 cm (SD=2.9). The most prevalent histologic appearance was cribriform, followed by tubular pattern. No significant relation was observed between lymph node metastasisand patients’ age, sex, disease duration, greatest tumor diameter and site of involvement.Conclusion: Our findings were relatively similar to other reports from different parts of the world. Further analytic and case-control studies are recommended to gain a better understanding of different aspects of ACC.

M. Khalili; F. Salamat

2009-01-01

204

Long-term outcomes of neoadjuvant intra-arterial cytoreductive chemotherapy for lacrimal gland adenoid cystic carcinoma.  

UK PubMed Central (United Kingdom)

PURPOSE: To compare the long-term outcomes after intra-arterial cytoreductive chemotherapy (IACC) with conventional treatment for lacrimal gland adenoid cystic carcinoma (ACC). DESIGN: Retrospective case series. PARTICIPANTS: Nineteen consecutive patients treated with IACC, followed by orbital exenteration, chemoradiotherapy, and intravenous chemotherapy. INTERVENTIONS: Analyses of the histologic characteristics of biopsy specimens, extent of disease at the time of diagnosis, diagnostic surgical procedures, incidence of locoregional recurrences or distant metastases, disease-free survival time, response to IACC, tumor margins at definitive surgery, and toxicity and complications. MAIN OUTCOME MEASURES: Disease relapse, disease-free survival, and chemotherapeutic complications. RESULTS: Eight patients with an intact lacrimal artery had significantly better outcomes for survival (100% vs. 28.6% at 10 years), cause-specific mortality, and recurrences (all P = 0.002, log-rank test) than conventionally treated patients from the University of Miami Miller School of Medicine. These 8 patients (group 1) had cumulative 10-year disease-free survival of 100% compared with 50% for 11 patients (group 2) who had an absence of the lacrimal artery or deviated from the treatment protocol (P = 0.035) and 14.3% for conventionally treated patients (P<0.001). Likewise, group 2 was associated with lower cause-specific mortality than the institutional comparator group (P = 0.038). Prior tumor resection with lateral wall osteotomy, delay in IACC implementation or exenteration, and failure to adhere to protocol are risk factors for suboptimal outcomes. CONCLUSIONS: Neoadjuvant IACC seems to improve overall survival and decrease disease recurrence. An intact lacrimal artery, no disruption of bone barrier or tumor manipulation other than incisional biopsy, and protocol compliance are factors responsible for favorable outcomes. The chemotoxicity complication rate is limited and manageable.

Tse DT; Kossler AL; Feuer WJ; Benedetto PW

2013-07-01

205

The Role of Radiation Therapy in the Treatment of Adenoid Cystic Carcinoma of the Head and Neck  

Energy Technology Data Exchange (ETDEWEB)

Forty eight patients with adenoid cystic carcinoma(ACC) in the head and beck treated between 1979 and 1990 were reviewed according to treatment modalities and clinical courses. The common site of origin was minor salivary gland (69%), mostly had palate and maxillary sinus. 11 patients received radiation therapy(RT) alone and 37 patients received combined surgery and radiation therapy. The follow-up period of the survivors ranged from 4 to 118 months (median 49.5 months). The 5 year local control rate was 69.3%, 67.3% and 83.9% in RT alone, conservative operation(OP)+RT and radical OP+RT group, respectively(p>0.05). The control of local disease was best achieved with radical OP+RT. In postoperative RT, high dose ({>=}60 Gy) and generous field size (>64cm{sup 2}) yielded a better local control rate. Actuarial overall survival rate was 79.0%, at 5 years and 19.2% at 10 years. Distant metastases (DM) developed in 40% of patients, mostly in the lung. Disease-free(NED) survival rate was 45.8%, at 5 years and significant differences did not exist according to primary sites and treatment options. Survival rate after the onset of DM was 19.5% at 5 years. Occurrence of DM tends to lower survival significantly. In an effort to find the role of RT in the treatment of ACC, our data suggest that a well-planned postoperative RT employing a high dose and generous field size can produce high local control rate and remaining urgent problem of distant metastasis demands more effective chemotherapy for the purpose of improving survival of ACC patients.

Kim, Won Dong; Park, Charn Il; Kim, Kwang Hyun [Seoul National University College of Medicine, Seoul (Korea, Republic of)

1992-06-15

206

Combined treatment of adenoid cystic carcinoma with cetuximab and IMRT plus C12 heavy ion boost: ACCEPT [ACC, Erbitux® and particle therapy  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background Local control in adjuvant/definitive RT of adenoid cystic carcinoma (ACC) is largely dose-dependent leading to the establishment of particle therapy in this indication. However, even modern techniques leave space for improvement of local control by intensification of local treatment. Radiation sensitization by exploitation of high EGFR-expression in ACC with the EGFR receptor antibody cetuximab seems promising. Methods/design The ACCEPT trial is a prospective, mono-centric, phase I/II trial evaluating toxicity (primary endpoint: acute and late effects) and efficacy (secondary endpoint: local control, distant control, disease-free survival, overall survival) of the combined treatment with IMRT/carbon ion boost and weekly cetuximab in 49 patients with histologically proven (?R1-resected, inoperable or Pn+) ACC. Patients receive 18 GyE carbon ions (6 fractions) and 54 Gy IMRT (2.0 Gy/fraction) in combination with weekly cetuximab throughout radiotherapy. Discussion The primary objective of ACCEPT is to evaluate toxicity and feasibility of cetuximab and particle therapy in adenoid cystic carcinoma. Trial Registration Clinical Trial Identifier: NCT 01192087 EudraCT number: 2010 - 022425 - 15

Jensen Alexandra D; Nikoghosyan Anna; Hinke Axel; Debus Jürgen; Münter Marc W

2011-01-01

207

Cervical adenoid basal carcinoma associated with invasive squamous cell carcinoma: A report of rare co-existence and review of literature  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Cervical adenoid basal carcinoma (ABC) rarely can harbor associated malignancies like adenoid cystic carcinoma or squamous cell carcinoma (SCC), which express markedly different prognosis from a pure ABC, making an appropriate biopsy essential to provide a clear diagnosis and therapeutic plan. We report a 64-year-old asymptomatic lady with an abnormal cervical cytology, who underwent a conization to reveal an ABC with overlying microinvasive SCC. Doubtful resection margins led us to perform radical hysterectomy with lymph node dissection. Subsequent pathological examination showed a true invasive SCC co-existing with ABC, with invasion of the parametrium. Unlike the indolent course of many pure ABC patients, the prognosis of 11 previously reported co-existing invasive SCC with ABC patients appears to depend on the SCC component. Our case reiterates the importance of adequate biopsy with careful interpretation to cover the possibility of a co-existent malignancy. Besides, it presents an argument in favor of radical surgery for the primary treatment of suspicious associated malignancy, and supports adjuvant treatment according to the unfavorable extent of the co-existent invasive carcinoma.

Viriyapak Boonlert; Park Sung Taek; Lee Ah Won; Park Jong Sup; Lee Chung Won; Song Min Jong; Hur Soo Young

2011-01-01

208

SIKVAV, a Laminin ?1-Derived Peptide, Interacts with Integrins and Increases Protease Activity of a Human Salivary Gland Adenoid Cystic Carcinoma Cell Line through the ERK 1/2 Signaling Pathway  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Adenoid cystic carcinoma is a frequently occurring malignant salivary gland neoplasm. We studied the induction of protease activity by the laminin-derived peptide, SIKVAV, in cells (CAC2) derived from this neoplasm. Laminin ?1 and matrix metalloproteinases (MMPs) 2 and 9 were immunolocalized in aden...

Freitas, Vanessa M.; Vilas-Boas, Vanessa F.; Pimenta, Daniel C.; Loureiro, Vania; Juliano, Maria A.; Carvalho, Márcia R.

209

Carcinoma adenoideo quístico de la próstata: Presentación de 2 casos/ Cystic adenoid carcinoma of the prostate: Report of two cases  

Scientific Electronic Library Online (English)

Full Text Available Abstract in spanish Objetivo: Presentamos dos casos con diagnóstico histológico de carcinoma adenoideo quístico de la próstata, tumor de presentación extremadamente raro. Métodos: Evaluamos a dos pacientes con edad de presentación, manifestación clínica, diagnóstico, tratamiento y evolución distintos. Resultados: La edad varia de 41 y 59 años, con dolor perineal y sintomatología urinaria baja, tacto rectal masa tumoral redondeada y dura o normal respectivamente. El antígeno pro (more) stático específico y la fosfatasa ácida prostática son normales, el ultrasonido transrectal puede ser normal o aportar con el hallazgo de nódulo hipoecoico, se realizó tratamiento quirúrgico con prostatectomía radical e inmunoterapia adyuvante en el primero que a los 6 años evoluciona a metastasis pulmonar y muere, el otro cistoprostatectomía radical con derivación urinaria ortotópica con buena evolución a los dos años. Conclusiones: La clínica es inespecífica, generalmente el diagnóstico es mediante resección transuretral o biopsia transrectal ante la sospecha por tacto rectal o ultrasonido, es inmunoreactivo para p53 y citoqueratinas 7 y 34 beta E12 y el tratamiento de elección es la cistoprostatectomía radical debido a que es una neoplasia potencialmente agresiva y puede añadirse tratamiento adyuvante. Abstract in english Objective: We report two cases with the pathologic diagnosis of cystic adenoid carcinoma of the prostate, an extremely rare tumor. Methods: We evaluate two patients with different age, clinical presentation, diagnosis, treatment and outcome. Results: The ages were 41 and 59, the symptoms perineal pain and lower urinary tract symptoms, on digital rectal examination a round hard tumor mass and normal exam, respectively. PSA and prostatic acid phosphatase were normal; Transr (more) ectal ultrasound may be normal or find a hypoechoic node. The first patient underwent radical prostatectomy and adjuvant immunotherapy; six years after surgery he developed lung metastasis and died. The second patient underwent radical cystoprostatectomy with orthotopic urinary diversion with good outcome after two years of follow-up. Conclusions: The clinical presentation is non specific, with the diagnosis generally obtained by transurethral resection or transrectal biopsy after the suspicion of an abnormal digital rectal examination or ultrasound. The tumor is immunoreactive to p53 and citokeratins 7 and 34 Beta E12, and the treatment of choice is radical cystoprostatectomy because it is a potentially aggressive neoplasia; adjuvant treatment may be added.

Pedro Silva, Isis E.; Osorio Acosta, Vicente; Farfán Chávez, F. Albaro

2006-10-01

210

The effect of proteoglycans inhibited by RNA interference on metastatic characters of human salivary adenoid cystic carcinoma  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background Salivary adenoid cystic carcinoma (SACC) is one of the most common malignancies of salivary gland. Recurrence or/and early metastasis is its biological properties. In SACC, neoplastic myoepithelial cells secrete proteoglycans unconventionally full of the cribriform or tubular and glandular structures of SACC. Literatures have demonstrated that extracellular matrix provided an essential microenvironment for the biological behavior of SACC. However, there is rare study of the effect of proteoglycans on the potential metastasis of SACC. In this study, human xylosyltransferase-I (XTLY-I) gene, which catalyzes the rate-limited step of proteoglycans biosynthesis, was knocked down by RNA interference (RNAi) to inhibit the proteoglycans biosynthesis in SACC cell line with high tendency of lung metastasis (SACC-M). The impact of down-regulated proteoglycans on the metastasis characters of SACC-M cells was analyzed and discussed. This research could provide a new idea for the clinical treatment of SACC. Methods The eukaryotic expression vector of short hairpin RNA (shRNA) targeting XTLY-I gene was constructed and transfected into SACC-M cells. A stably transfectant cell line named SACC-M-WJ4 was isolated. The XTLY-I expression was measured by real-time PCR and Western blot; the reduction of proteoglycans was measured. The invasion and metastasis of SACC-M-WJ4 cells were detected; the effect of down-regulated proteoglycans on the potential lung metastasis of nude mice was observed, respectively. Results The shRNA plasmid targeting XTLY-I gene showed powerful efficiency of RNAi. The mRNA level of target gene decreased by 86.81%, the protein level was decreased by 80.10%, respectively. The silence of XTLY-I gene resulted in the reduction of proteoglycans significantly in SACC-M-WJ4 cells. The inhibitory rate of proteoglycans was 58.17% (24 h), 66.06% (48 h), 57.91% (72 h), 59.36% (96 h), and 55.65% (120 h), respectively. The reduction of proteoglycans suppressed the adhesion, invasion and metastasis properties of SACC-M cells, and decreased the lung metastasis of SACC-M cells markedly either. Conclusion The data suggested that the silence of XTLY-I gene in SACC-M cells could suppress proteoglycans biosynthesis and secretion significantly. The reduction of proteoglycans inhibited cell adhesion, invasion and metastasis of SACC-M cells. There is a close relationship between proteoglycans and the biological behavior of SACC.

Shi Hong; Wang Jie; Dong Fusheng; Wang Xu; Li Hexiang; Hou Yali

2009-01-01

211

Estudo clínico, randomizado, duplo-cego, em crianças com adenóide obstrutiva, submetidas a tratamento homeopático/ Prospective, randomized, double-blind clinical trial about efficacy of homeopathic treatment in children with obstructive adenoid  

Scientific Electronic Library Online (English)

Full Text Available Abstract in portuguese OBJETIVO: Avaliar a eficácia e segurança do tratamento homeopático em crianças com adenóide obstrutiva, com indicação cirúrgica. FORMA DE ESTUDO: Clínico prospectivo. Material e método: Estudo prospectivo, duplo-cego, randomizado, em que foram incluídas 40 crianças com idade variando de 3 a 7 anos, 20 crianças foram tratadas com medicação homeopática individualizada (Simillimum), baseada no princípio da similitude e 20 crianças receberam placebo. Todas a (more) s crianças do grupo medicação homeopática foram medicadas diariamente com Agraphis nutans 6 CH, Thuya 6 CH e Adenóide 21CH; e as do grupo placebo receberam diariamente medicamentos sem o princípio ativo. A duração do estudo de cada paciente foi de 4 meses. A avaliação dos resultados foi clínica, por meio de questionário padrão, de exame otorrinolaringológico e nasofaringoscopia direta com fibroscópio flexível, no primeiro e no último dia de tratamento. Utilizou-se como critério de inclusão a adenóide que ocupou mais do que 70% da luz coanal. RESULTADOS: Das 20 crianças tratadas com medicamento homeopático, 13 não apresentaram alteração no tamanho da adenóide nos exames nasofaringoscópicos e 7 tiveram diminuição da adenóide; das 20 crianças que receberam placebo por 4 meses, 11 não apresentaram alterações no tamanho da adenóide, 4 tiveram diminuição da adenóide e 5 crianças tiveram aumento. Não houve diferença estatística significante entre os grupos (P= 0,069). Na avaliação clínica da evolução dos pacientes, dos 20 pacientes tratados com medicamento homeopático, 17 se mantiveram inalterados, com respiração oral e ronco, um paciente melhorou, ficando sem ronco e dois foram curados, isto é, a respiração alterou-se de oral para nasal e sem ronco. Dos 20 pacientes tratados com placebo, 17 pacientes se mantiveram inalterados, um paciente melhorou do ronco e dois foram curados, não tendo havido diferença estatística significante entre os grupos (P>0,999). CONCLUSÕES: O tratamento homeopático não foi eficaz nas crianças com adenóide obstrutiva, mantendo-se a indicação cirúrgica em 85% dos pacientes. O medicamento homeopático não provocou eventos adversos nas crianças. Abstract in english AIM: the efficacy and security of homeopathic treatment was investigated on children with obstructive adenoid justifying an operation. STUDY DESIGN: Clinical prospective. MATERIAL AND METHOD: In a prospective, randomized, double-blind clinical trial included 40 children between the ages of 3 to 7 years old, 20 children were treated with homeopathic medication, based in the principle of similarity (Simillimum), and 20 children with placebo. All the children of the homeopat (more) hic group/ adenoid, were treated daily with Agraphis nutans 6 CH, Thuya 6 CH and Adenoid 21CH, and the patients of the placebo group received daily placebo medication. The duration of the study of each children was 4 months. The evaluation of the results was clinical, and it was made by questionnaire standard, clinical examination and direct flexible fiberoptic nasopharyngoscopy, in the first and last day of treatment. The criterion of selection was the adenoid that occuped more than 70% of the coanal space. RESULTS: From the group of 20 children treated with homeopathic treatment, 13 did not show any change on the size of adenoid after nasopharyngoscopy, and 7 children had their adenoid decreased; from another group of 20 children that have treated with placebo for 4 months, 11 did not show any change on the size of their adenoid, 4 had their adenoid decreased and 5 had their adenoid increased. The statistical analysis showed a not significant difference (P= 0,069). The clinical evaluation of the patients showed that from the group of 20 patients treated with homeopathy, 17 kept unchanging, with oral breathing and snoring, one patient got better, eliminating the snoring and two were cured, which mean that their oral breathing turned to nasal breathing without snoring. From the group of

Furuta, Sergio E.; Weckx, Luc L.M.; Figueiredo, Claudia R.

2003-06-01

212

[Recurrent secretory otitis media and adenoidism. A retrospective study of the results observed with the medical and surgical therapy of 1250 children  

UK PubMed Central (United Kingdom)

A retrospective study, between 1982 and 1993, on 1250 children with otitis media with effusion and hypertrophic adenoids was carried out. 1150 children were selected from those who had been administered S-carboxymethylcysteine-lysine for three months period, and antihistaminics, decongestants and anti-inflammatory drugs as concomitant treatment and 100 children from those who had undergone adenoidectomy. ORL-examination, audiometry and tympanometry, before and after the period of the therapy, were performed. No significant differences were found between the two groups with a percentage of successful outcome of 77-79%. On the basis of the data obtained, the tendency of avoiding surgical management by using the appropriate pharmacological therapy is underlined, particularly taking into consideration the safety profile of the medical treatment.

Vivian R

1994-10-01

213

In vitro angiogenesis and expression of nuclear factor ?B and VEGF in high and low metastasis cell lines of salivary gland Adenoid Cystic Carcinoma  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background Adenoid cystic carcinoma is a high malignant carcinoma characterized by intensive local invasion and high incidence of distant metastasis. Although many reports have demonstrated that angiogenesis has played an important role in tumor metastasis, the relationship between metastasis characters and angiogenesis ability in high and low metastasis cell lines of Adenoid cystic carcinoma has rarely been reported. The present study aimed to compare the angiogenesis ability of ACC-M (high metastasis) and ACC-2 (low metastasis) cell lines in vitro. Furthermore, the activity of nuclear factor ?appa B and the expression of vascular endothelial growth factor (VEGF) in ACC-2 and ACC-M were also detected. Methods Electrophoretic mobility shift assay was used to detect nuclear factor ?appa B activity. Semi-quantitative RT-PCR was used to quantify the mRNA level of VEGF. Immuofluorescence double staining and semi-quantitative confocal laser scanning analysis was carried out to detect nuclear factor ?appa B nuclear localization and staining intensity of VEGF. The angiogenesis ability of ACC-M and ACC-2 was compared by an in vitro three-dimensional angiogenic model assay. The vector transfection assay was performed to transfect the PCMV-I?B?M vector into ACCs cell lines expressing the phosphorylation defective I?B?M. Results Nuclear factor ?appa B activity and the rate of nuclear factor ?appa B nuclear localization in ACC-M was significantly higher than that in ACC-2. Moreover, ACC-M exhibited higher mRNA and protein levels of vascular endothelial growth factor than ACC-2. VEGF mRNA expression was effectively decreased by inhibition of nuclear factor ?appa B activity. Furthermore, ACC-M could remarkably stimulate the migration and tube formation of endothelial cells and induce The umbilical vein endothelial cells sprouting into the gel matrix. Conclusion These results implicated that ACCs cells with higher metastasis feature might present greater angiogenesis ability.

Zhang Jiali; Peng Bin

2007-01-01

214

[Adenoid cystic cribriform trichoblastoma  

UK PubMed Central (United Kingdom)

In hair germ tumors, hair follicle development is partially or completely recapitulated. The trichoblastoma represents a purely epithelial tumour within this group of tumours. We identified a trichoblastoma showing exclusively adenocystic features in a 32 years old woman. This variant has been very rarely described in the literature. We review the history of hair germ tumors and discuss the problems of their classification.

Betti R; Cerri A; Moneghini L; Inselvini E; Crosti C

1997-06-01

215

Therapy of metastasized differentiated thyroid carcinoms  

International Nuclear Information System (INIS)

Therapy with radioiodine is the only curative option in differentiated metastasized thyroid carcinoma (subsequent to surgical intervention). Therapy in case of metastases is of particular relevance in patients with thyroid carcinoma of stage pT4, i.e. in case of expansive growth, as this stage is characterized by frequent hematogenous dissemination of tumor cells. As to histology there are prognostic differences: Follicular thyroid carcinomas are more frequently associated with osseous metastases than papillary carcinomas, and osseous metastases can only be successfully treated in a relatively small percentage. In cases of initial osseous metastases, however, the results of radioiodine therapy are more promising. Compared with delayed development of osseous metastases, initial metastases show significantly radioiodine uptake on average. To date, it has been clarified that there are good chances to cure patients with initial bone metastases by consequent high-dose radioiodine therapy, contrary to wide-spread opinion. Apart from radioiodine uptake, tumor stage, histology, and location of metastases, the patient's age at manifestation of disease is a further prognostic factor when treating metastases of the differentiated thyroid carcinoma. The potential of therapy is limited by hematoxicity when the dose administered exceeds 50-100 GBq. Alternative modalities of therapy like external radiation or chemotherapy by itself or combined with radiation are not sufficiently effective until now. Recently developed therapeutic concepts are still in an experimental stage. After a period of stagnation in methodological development of radioiodine therapy, modifications of treatment modalities (e.g., by combining external radiation with chemotherapy, by applying retinoids or rhTSH etc.) are being evaluated. (orig./MG)

2000-01-01

216

Estudo comparativo radiológico e nasofibroscópico do volume adenoideano em crianças respiradoras orais/ Comparison between radiological and nasopharyngolaryngoscopic assessment of adenoid tissue volume in mouth breathing children  

Scientific Electronic Library Online (English)

Full Text Available Abstract in portuguese A tonsila faríngea ou adenóides é a extensão superior do anel linfático de Waldeyer e está localizada na porção alta da cavidade nasofaríngea, próxima à tuba auditiva e à coana. Ela desempenha um papel relevante nas otites médias recorrentes e freqüentemente sua hipertrofia é responsável pela obstrução das vias aéreas superiores. A tonsilectomia é um tratamento comumente realizado para doenças crônicas das tonsilas e ainda é o procedimento cirúrgic (more) o mais freqüente e mais antigo realizado em crianças e adultos jovens. Os critérios para a realização da tonsilectomia, o efeito da mesma na integridade imunológica do paciente e seus riscos inerentes à cirurgia são muito discutíveis e controversos em todo o mundo. Estudos de imagem utilizando-se o raio-X do cavo é um método simples, fácil e confortável para avaliar o tamanho das adenóides e o grau de obstrução das vias aéreas superiores. Um estudo nasofibroscópico da nasofaringe pode fornecer uma informação melhor sobre essa região, tendo em vista que ele mostra todas as estruturas presentes na nasofaringe e o grau de obstrução das vias aéreas superiores de forma dinâmica. FORMA DE ESTUDO: Clínico não randomizado. MATERIAL E MÉTODO: Este estudo comparou o grau de hipertrofia e de obstrução das vias aéreas superiores, usando os dois métodos acima, em crianças de 3 a 10 anos de idade, constatando que a nasofibroscopia flexível é um método diagnóstico excepcionalmente mais fidedigno do que o raio-x do cavo, na avaliação volumétrica da adenóide. Abstract in english The pharyngeal tonsil (adenoid) constitutes the upper portion of the Waldeyer's ring and is located at the top of the nasopharynx, next to the auditory tube and choana. It plays an important role in recurrent otitis of the middle ear and many times its enlargement is responsible for upper airway obstruction. Tonsillectomy is often the treatment of choice for tonsillar diseases. So far, it is the most frequent and one of the oldest surgical procedures performed in children (more) and young adults. The criteria for tonsillectomy, its effect on patient's immunological integrity and the surgical risks are widely controversial. Image study using paranasal sinuses x-ray is a very simple, easy and comfortable method to evaluate the sizes of adenoids and the grade of upper airway obstruction. Cohen et al. supported that paranasal sinuses x-ray is the best way to determine pharyngeal tonsil hypertrophy. On the other hand, nasopharyngolaryngoscopy can provide more accurate data on the nasopharynx, as it can dynamically reveal its structures and the obstruction status of the upper airway. This study compared the grade of adenoid hypertrophy, as well as upper airway obstruction, using the above-mentioned approaches in children ranging from 3 to 10 years old. The study came to the conclusion that nasopharyngolaryngoscopy is a much more accurate diagnostic procedure than radiological evaluation of the nasopharynx.

Lourenço, Edmir Américo; Lopes, Karen de Carvalho; Pontes Jr., Álvaro; Oliveira, Marcelo Henrique de; Umemura, Adriana; Vargas, Ana Laura

2005-02-01

217

Estudo comparativo radiológico e nasofibroscópico do volume adenoideano em crianças respiradoras orais Comparison between radiological and nasopharyngolaryngoscopic assessment of adenoid tissue volume in mouth breathing children  

Directory of Open Access Journals (Sweden)

Full Text Available A tonsila faríngea ou adenóides é a extensão superior do anel linfático de Waldeyer e está localizada na porção alta da cavidade nasofaríngea, próxima à tuba auditiva e à coana. Ela desempenha um papel relevante nas otites médias recorrentes e freqüentemente sua hipertrofia é responsável pela obstrução das vias aéreas superiores. A tonsilectomia é um tratamento comumente realizado para doenças crônicas das tonsilas e ainda é o procedimento cirúrgico mais freqüente e mais antigo realizado em crianças e adultos jovens. Os critérios para a realização da tonsilectomia, o efeito da mesma na integridade imunológica do paciente e seus riscos inerentes à cirurgia são muito discutíveis e controversos em todo o mundo. Estudos de imagem utilizando-se o raio-X do cavo é um método simples, fácil e confortável para avaliar o tamanho das adenóides e o grau de obstrução das vias aéreas superiores. Um estudo nasofibroscópico da nasofaringe pode fornecer uma informação melhor sobre essa região, tendo em vista que ele mostra todas as estruturas presentes na nasofaringe e o grau de obstrução das vias aéreas superiores de forma dinâmica. FORMA DE ESTUDO: Clínico não randomizado. MATERIAL E MÉTODO: Este estudo comparou o grau de hipertrofia e de obstrução das vias aéreas superiores, usando os dois métodos acima, em crianças de 3 a 10 anos de idade, constatando que a nasofibroscopia flexível é um método diagnóstico excepcionalmente mais fidedigno do que o raio-x do cavo, na avaliação volumétrica da adenóide.The pharyngeal tonsil (adenoid) constitutes the upper portion of the Waldeyer's ring and is located at the top of the nasopharynx, next to the auditory tube and choana. It plays an important role in recurrent otitis of the middle ear and many times its enlargement is responsible for upper airway obstruction. Tonsillectomy is often the treatment of choice for tonsillar diseases. So far, it is the most frequent and one of the oldest surgical procedures performed in children and young adults. The criteria for tonsillectomy, its effect on patient's immunological integrity and the surgical risks are widely controversial. Image study using paranasal sinuses x-ray is a very simple, easy and comfortable method to evaluate the sizes of adenoids and the grade of upper airway obstruction. Cohen et al. supported that paranasal sinuses x-ray is the best way to determine pharyngeal tonsil hypertrophy. On the other hand, nasopharyngolaryngoscopy can provide more accurate data on the nasopharynx, as it can dynamically reveal its structures and the obstruction status of the upper airway. This study compared the grade of adenoid hypertrophy, as well as upper airway obstruction, using the above-mentioned approaches in children ranging from 3 to 10 years old. The study came to the conclusion that nasopharyngolaryngoscopy is a much more accurate diagnostic procedure than radiological evaluation of the nasopharynx.

Edmir Américo Lourenço; Karen de Carvalho Lopes; Álvaro Pontes Jr.; Marcelo Henrique de Oliveira; Adriana Umemura; Ana Laura Vargas

2005-01-01

218

Cetuximab and platinum-based chemoradio- or chemotherapy of patients with epidermal growth factor receptor expressing adenoid cystic carcinoma: a phase II trial.  

Science.gov (United States)

Background:Epidermal growth factor receptor (EGFR) is highly expressed in adenoid cystic carcinoma (ACC). The efficacy and toxicity of cetuximab with concomitant platinum-based chemoradio- or chemotherapy in patients with locally advanced or metastatic ACC, respectively, was evaluated.Methods:Eligible patients (9 with locally advanced tumour and 12 with metastases) had positive tumour EGFR expression. The cetuximab loading dose (400?mg?m(-2)) was followed by 250?mg?m(-2) per week. Locally advanced tumours were irradiated (mean dose 65?Gy) and treated with concomitant cisplatin (75?mg?m(-2), intravenously). Patients with metastases received concomitant cisplatin and 5-fluorouracil (4 × 1000?mg?m(-2)).Results:For patients with locally advanced disease (median follow-up: 52 months), the median progression-free survival (PFS) was 64 months and the 2-year overall survival (OS) rate was 100%. For patients with metastases (median follow-up: 72 months), the median PFS and OS were 13 and 24 months, respectively. In both groups the objective response rate was >40%. Skin rash, in-field dermatitis, mucositis and vomiting were the most frequent grade 3/4 adverse events.Conclusion:In this single-arm study, the efficacy of cetuximab plus chemoradio- or chemotherapy appeared favourable as compared with historical controls. All side effects were manageable and did not hamper the treatment. PMID:23942070

Hitre, E; Budai, B; Takácsi-Nagy, Z; Rubovszky, G; Tóth, E; Remenár, E; Polgár, C; Láng, I

2013-08-13

219

Downregulation of runt-related transcription factor 3 associated with poor prognosis of adenoid cystic and mucoepidermoid carcinomas of the salivary gland.  

UK PubMed Central (United Kingdom)

Runt-related transcription factor 3 (RUNX3) is a transcription factor of the transforming growth factor (TGF)-? superfamily and acts as a tumor suppressor gene, which is silenced by hypermethylation of the promoter region in various cancers. In this study, we examined the expression and methylation status of RUNX3 in the salivary gland cancers pleomorphic adenoma (PA), adenoid cystic carcinoma (ACC) and mucoepidermoid carcinoma (MEC). The cytoplasmic expression rates of RUNX3 in PA, ACC and MEC were 65% (13/20), 22.2% (8/36) and 20.6% (7/34), respectively. Low expression or deletion of RUNX3 in ACC and MEC was significantly associated with tumor progression and poor prognosis. Using microdissected cDNA, we found that RUNX3 mRNA expression was lower in ACC and MEC than in PA and noncancerous salivary glands; furthermore, hypermethylation of RUNX3 was detected more frequently in PA (2/8, 25%), ACC (6/8, 75%) and MEC (7/8, 87.5%) than in noncancerous salivary glands (0/8, 0%). Our results suggest that low expression or deletion of RUNX3 in salivary gland tumors might play a pivotal role in tumorigenesis and tumor progression and poor prognosis in the case of salivary gland ACC and MEC. Recovery of the tumor suppressive function of RUNX3 might inhibit tumorigenesis and cancer progression in the human salivary gland.

Sasahira T; Kurihara M; Yamamoto K; Bhawal UK; Kirita T; Kuniyasu H

2011-02-01

220

Management of salivary gland adenoid cystic carcinoma: institutional experience of a case series/ Conduta no carcinoma adenóide cístico de glândula salivar: série de casos em experiência institucional  

Scientific Electronic Library Online (English)

Full Text Available Abstract in portuguese CONTEXTO E OBJETIVO: Tumores de glândulas salivares exigem acompanhamento clínico por longos períodos devido à evolução indolente dessas neoplasias e à possibilidade tardia de recidivas locais e metástases a distância. O carcinoma adenóide cístico (CAC) compreende 10% a 15% dos tumores de glândulas salivares. O objetivo deste trabalho é analisar a conduta terapêutica, o estadiamento e o acompanhamento de pacientes com CAC em cabeça e pescoço em instituiç? (more) ?o de ensino. TIPO DE ESTUDO E LOCAL: Estudo retrospectivo realizado no Serviço de Cirurgia de Cabeça e Pescoço, Universidade Estadual de Campinas. MÉTODOS: Revemos o tratamento do CAC de 21 pacientes tratados entre 1993 e 2003. Os pacientes foram estadiados conforme os critérios clínicos da União Internacional Contra o Câncer (UICC) de 1998 e o tratamento foi baseado na avaliação clínica e imagenológica. RESULTADOS: 11 tumores estavam localizados nas glândulas salivares maiores (52,3%), sendo sete em glândula submandibular e quatro em parótida. Em 10 pacientes (47,7%), os tumores estavam em glândulas salivares menores (todos em palato). Quando ocorreram em glândula salivar maior, a submandibular foi a mais acometida. O diagnóstico foi realizado quase sempre por punção aspirativa por agulha fina (PAAF) ou biópsia. Biópsia por congelação no intraoperatório foi realizada em seis pacientes. Obtivemos boa correlação entre o ultra-som e a PAAF. Em 16 pacientes (76%), a radioterapia pós-operatória foi realizada. Um dos pacientes (4,7%) foi a óbito pelo CAC e cinco tiveram recidivas da doença, sendo três locoregionais (14,2%) e dois (9,5%) por metástases a distância. CONCLUSÃO: Carcinoma adenóide cístico apresenta comportamento agressivo localizado. Em 21 casos, o nervo facial foi preservado, exceto nos raros pacientes com invasão grosseira pelo tumor. O tratamento baseou-se no exame físico, exames de imagem, estágio do tumor e diferenciação histológica. Abstract in english CONTEXT AND OBJECTIVE: Salivary gland tumor management requires long-term follow-up because of tumor indolence and possible late recurrence and distant metastasis. Adenoid cystic carcinoma (ACC) accounts for 10-15% of such tumors. The aim here was to evaluate surgical and clinical management, staging and follow-up of ACC patients in one academic institution. DESIGN AND SETTING: Retrospective study at Head and Neck Service, Universidade Estadual de Campinas. METHODS: Data (more) on 21 patients treated between 1993 and 2003 were reviewed. Management utilized clinical staging, histology and imaging. Major salivary gland tumor extent was routinely assessed by preoperative ultrasonography. Diagnosis, surgery type, margin type (negative/positive), postoperative radiotherapy and recurrence (presence/absence) were evaluated. RESULTS: There were eleven major salivary gland tumors (52.3%), seven submandibular and four parotid. Ten patients (47.7%) had minor salivary gland ACC (all in palate), while the submandibular was the most frequently affected major one. Diagnoses were mostly via fine-needle aspiration (FNA) and incision biopsy. Frozen sections were used for six patients. There was good ultrasound/FNA correlation. Sixteen (76%) had postoperative radiotherapy. One (4.7%) died from ACC and five now have recurrent disease: three (14.2%) locoregional and two (9.5%) distant metastases. CONCLUSION: Adenoid cystic carcinoma has locally aggressive behavior. In 21 cases, of ACC, the facial nerve was preserved in all except in the few with gross tumor involvement. Treatment was defined from physical examination, imaging, staging and histology.

Tincani, Alfio José; Del Negro, André; Araújo, Priscila Pereira Costa; Akashi, Hugo Kenzo; Martins, Antonio Santos; Altemani, Albina Milani; Barreto, Gilson

2006-02-01

 
 
 
 
221

18F-FDG PET/CT in Patients with Initially Diagnosed Adenoid Cystic Carcinoma of the Head and Neck: Clinicoplathologic Correlation  

International Nuclear Information System (INIS)

We evaluated 18F-FDG PET/CT findings in initially diagnosed adenoid cystic carcinoma (ACC) of the head and neck in association with pathological subtype, staging, uptake comparison with squamous cell carcinoma (SqCC) and prognosis. The subjects were 16 patients with initially diagnosed ACC of head and neck who underwent pretreatment 18F-FDG PET/CT. Histological subtype (solid pattern vs. tubular/cribriform pattern), SUVmax of size-matched SqCC of the head and neck as control group, disease-free survival (DFS) were compared with the SUVmax of ACC of the head and neck. Of total 16 patients, 6 had solid pattern and the remaining 10 had tubular/cribriform pattern. The SUVmax were significantly higher in solid pattern group than in tubular/cribriform pattern group (6.7±3.2 vs. 4.2±0.9, p=0.03). PET/CT found unexpected distant metastasis in 18.7% of patients (3/16) and changed the therapeutic plan in those patients. The SUVmax of ACC was significantly lower than that of size-matched SqCC (5.1±2.4 vs. 13.6±6.0, p18F-FDG uptake (SUVmax ?6.0) had significantly shorter DFS than those with low 18F-FDG uptake (SUVmax 18F-FDG uptake of ACC of the head and neck is significantly associated with histological subtype and DFS. 18F-FDG PET/CT may be useful for detecting unexpected metastasis. Since 18F-FDG uptake of tubular/cribriform ACC compared with SqCC is relatively low, it is necessary to interpret PET images carefully in patients without alleged ACC

2009-01-01

222

The T-box transcription factor Brachyury regulates epithelial–mesenchymal transition in association with cancer stem-like cells in adenoid cystic carcinoma cells  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background The high frequencies of recurrence and distant metastasis of adenoid cystic carcinoma (AdCC) emphasize the need to better understand the biological factors associated with these outcomes. To analyze the mechanisms of AdCC metastasis, we established the green fluorescence protein (GFP)-transfected subline ACCS-GFP from the AdCC parental cell line and the metastatic ACCS-M GFP line from an in vivo metastasis model. Methods Using these cell lines, we investigated the involvement of the epithelial–mesenchymal transition (EMT) and cancer stem cell (CSCs) in AdCC metastasis by real-time RT-PCR for EMT related genes and stem cell markers. Characteristics of CSCs were also analyzed by sphere-forming ability and tumorigenicity. Short hairpin RNA (shRNA) silencing of target gene was also performed. Results ACCS-M GFP demonstrated characteristics of EMT and additionally displayed sphere-forming ability and high expression of EMT-related genes (Snail, Twist1, Twist2, Slug, zinc finger E-box binding homeobox 1 and 2 [Zeb1 and Zeb2], glycogen synthase kinase 3 beta [Gsk3? and transforming growth factor beta 2 [Tgf-?2]), stem cell markers (Nodal, Lefty, Oct-4, Pax6, Rex1, and Nanog), and differentiation markers (sex determining region Y [Sox2], Brachyury, and alpha fetoprotein [Afp]). These observations suggest that ACCS-M GFP shows the characteristics of CSCs and CSCs may be involved in the EMT of AdCC. Surprisingly, shRNA silencing of the T-box transcription factor Brachyury (also a differentiation marker) resulted in downregulation of the EMT and stem cell markers. In addition, sphere-forming ability, EMT characteristics, and tumorigenicity were simultaneously lost. Brachyury expression in clinical samples of AdCC was extremely high and closely related to EMT. This finding suggests that regulation of EMT by Brachyury in clinical AdCC may parallel that observed in vitro in this study. Conclusions The use of a single cell line is a limitation of this study. However, parallel data from in vitro and clinical samples suggest the possibility that EMT is directly linked to CSCs and that Brachyury is a regulator of EMT and CSCs.

Shimoda Miyuki; Sugiura Tsuyoshi; Imajyo Ikumi; Ishii Kotaro; Chigita Satomi; Seki Katsuhiro; Kobayashi Yousuke; Shirasuna Kanemitsu

2012-01-01

223

Carcinoma adenoescamoso do colo uterino mimetizando carcinoma adenóide basal: relato de um caso e revisão da literatura/ Adenosquamous carcinoma of the cervix mimicking adenoid basal carcinoma: case report and review of the literature  

Scientific Electronic Library Online (English)

Full Text Available Abstract in portuguese O carcinoma adenoescamoso do colo uterino é definido como um tumor que contém uma mistura de células malignas com diferenciação escamosa e glandular. A literatura salienta a importância de se fazer esse diagnóstico, uma vez que, quando os componentes não são bem diferenciados ou não se encontram evidentes na amostra analisada, esse tumor pode ser erroneamente interpretado como carcinoma escamoso ou adenocarcinoma. O presente trabalho descreve a apresentação po (more) uco comum de um carcinoma adenoescamoso. Após sucessivos diagnósticos citológicos não concordantes e complicados por uma história de sangramento uterino anormal ocasionado por endometriose cervical, a paciente de 47 anos foi submetida a histerectomia total, obtendo diagnóstico definitivo. Esse particular tumor aqui relatado foi diagnosticado como carcinoma adenoescamoso, mas em muitos aspectos apresentou-se semelhante ao carcinoma adenóide basal. Elementos característicos do carcinoma adenóide basal, como presença de lesão intra-epitelial escamosa na superfície, diferenciação escamosa e glandular no centro dos blocos neoplásicos e células basalóides na profundidade da lesão, foram observados em nosso caso. Em contrapartida, os seguintes elementos normalmente não observados no carcinoma adenóide basal estavam presentes: atipias e figuras de mitose nas células indiferenciadas da profundidade do tumor e lesão intra-epitelial escamomucinosa (SMILE) na superfície. Fatores epidemiológicos e clínicos, como idade (47), raça (branca) e forma de apresentação clínica (massa visível na inspeção cervical), também colaboraram para afastar esse diagnóstico diferencial. Outros diagnósticos diferenciais do carcinoma adenoescamoso do colo uterino incluem o carcinoma puramente escamoso ou glandular, o tumor de colisão e o adenocarcinoma de endométrio com diferenciação escamosa invadindo o colo uterino. Abstract in english Adenosquamous carcinoma of the uterine cervix is defined as a tumor that contains a mixture of malignant cells with squamous and glandular differentiation. The literature points to the importance of making this diagnosis when the cellular components are still well differentiated in the sample, otherwise the tumor may be erroneously interpreted as squamous carcinoma or adenocarcinoma. This study describes an unusual presentation of a adenosquamous carcinoma in a 47 year ol (more) d patient. After conflicting cytological diagnoses and a history of abnormal uterine bleeding caused by cervical endometriosis, the patient was subjected to radical hysterectomy and a final diagnosis was obtained. The tumor was diagnosed as adenosquamous carcinoma. In many aspects, however, it was similar to the adenoid basal carcinoma. Characteristic features of the adenoid basal carcinoma such as the presence of high-grade squamous intraepithelial lesion in the surface epithelium, squamous and glandular differentiation in the center of the neoplastic mass, and basaloid cells in deep areas of the tumor were observed. Therefore, the following elements usually absent from adenoid basal carcinoma were present in this case: atypia and mitotic figures in undifferentiated cells, squamous-mucinous intraepithelial lesion (SMILE) in the superficial areas. Epidemiological and clinical data, such as patient age (47), race (white) and presentation (a cervical mass), concurred to exclude the diagnosis of adenoid basal carcinoma. Other differential diagnoses include pure squamous carcinoma or adenocarcinoma, collision tumor, and endometrial adenocarcinoma with squamous differentiation invading the uterine cervix.

Pinto, Álvaro Piazzeta; Maia, Luiz Roberto

2007-02-01

224

Carcinoma adenóide cístico de traquéia: tratamento pela laringotráqueo-esofagectomia e traqueostomia mediastinal Adenoid cystic carcinoma of the trachea: treatment by removing the larynx, trachea, and esophagus, and mediastinal tracheostomy  

Directory of Open Access Journals (Sweden)

Full Text Available Os autores descrevem o caso de uma paciente de 54 anos de idade com carcinoma adenóide cístico de traquéia ao nível da cricóide, na qual foi realizada ressecção extensa, incluindo a laringe, parte da traquéia e esôfago. A reconstrução do trato digestivo foi através do tubo gástrico e a via aérea pela construção de uma traqueostomia mediastinal. Cinco anos mais tarde foi removida uma recorrência tumoral cutânea no pescoço. Sete anos depois do procedimento original, foi notada nova recorrência no mediastino, que respondeu à irradiação. A paciente encontra-se muito bem atualmente, oito anos e cinco meses após o procedimento.The authors describe the case of a 54 year-old female with adenoid cystic carcinoma of the trachea at the cricoid level upon whom extensive surgical resection was performed, including the larynx, part of the trachea and esophagus. Reconstruction of the digestive tract was done by means of a gastric tube and the airway with a mediastinal tracheostomy. Five years after the original procedure there was a local cutaneous recurrence which was removed. Seven years later the disease recurred in the mediastinum, which responded to irradiation. The patient is alive and well eight years and five months after the operation.

Manoel Ximenes Netto; Gutemberg F. Rego; André L.A. Carvalho; Hélcio L. Miziara

1999-01-01

225

P53 gene snp investigation in squamous cell oesophageal carcinom  

Directory of Open Access Journals (Sweden)

Full Text Available Squamous cell cancer (ESCC) and adenocarcinoma (EADC) are the two main subtypes of oesophageal cancer. Genetic alterations associated with the development of oesophageal cancer are often observed. The aim of this study was to identify p53 gene polymorphisms in several patients with oesophageal squamous cell carcinoma. Genomic DNA was isolated from normal-, tumor- and blood-samples from patients with ESCC. PCR amplification of two p53 gene fragments was performed using two sets of primers DNA samples were sequenced and then analyzed with BLAST program Exons 5, 7 and 8 did not present mutations for the studied patients, but exon 6 featured one modification in two different patients. The mutations of p53 gene can determine the modification of its proteine function and the loss of its antioncogene role, which reflects the abnormal proliferation of the cells implicated in this type of cancer.

Catalina Luca; Laura Buburuzan; Dragos Romanescu; Codrut Stanescu; Simona Dima; Irinel Popescu; Vladimir Botnarius; Marieta Costache

2010-01-01

226

Modalidad quirúrgica como alternativa en la otitis media serosa por hipertrofia adenoidea: Pinar del Río, 2008 An alternative surgical method in the serous otitis media due to adenoid hypertrophia: Pinar del Rio, 2008  

Directory of Open Access Journals (Sweden)

Full Text Available La hipoacusia tiene repercusión negativa en el aprendizaje y comportamiento social de los niños, por lo que se hace necesaria la aplicación de técnicas quirúrgicas cada día más eficientes que reduzcan esta problemática. Con el objetivo de demostrar la eficacia de una nueva modalidad quirúrgica consistente en realizar adenoidectomía y doble miringotomía con aspiración del contenido seromucoso y de proponer una estrategia para solución quirúrgica definitiva en el nivel secundario y preventiva en el nivel primario, se realizó una investigación de innovación _ tecnológica, descriptiva, longitudinal prospectiva en niños con hipoacusia conductiva por otitis media serosa secundaria a hipertrofia adenoidea, que asistieron a las consultas de audiología del Hospital Pediátrico Provincial Docente" Pepe Portilla" y del Policlínico Universitario Dr." Ernesto Guevara" de Sandino. El universo estuvo constituido por todos los niños con hipoacusia conductiva registrados en consulta de audiología. La muestra resultó de 109 pacientes con hipoacusia por Otitis Media Serosa secundaria a Hipertrofia Adenoidea, provenientes de 10 municipios de nuestra provincia, entre los 4 y 12 años de edad; mediante muestreo intencional. A todos los pacientes se les realizó examen otorrinolaringológico y audiometría tonal. Se utilizaron métodos de encuesta, análisis documental y de la Estadística Descriptiva utilizando medidas de frecuencias absolutas y relativas porcentuales. Se calcularon intervalos de confianza para algunas de las frecuencias relativas buscadas y previo consentimiento informado se trataron quirúrgicamente, reevaluados en consulta, donde se comprobó que 108 pacientes evolucionaron satisfactoriamente, concluyendo que es una técnica eficaz.Hypoakusia has a negative repercussion in learning and social behaviour in children so it is mandatory the implementation of surgical techniques in order to minimize this condition.. A new descriptive longitudinal and prospective technique was performed in children suffering from conductive hypoakusia due to serous otitis media secondary to adenoid hypertrophia attending to the hearing care office at "Pepe Portilla"Pediatric Hospital and "Dr.Ernesto Guevara "Policlinic in Sandino in order to show the efficacy of a new definitive surgical technique (adenotomy and double miringotomy with aspiration of the seromucus content ) and to propose an strategy for a definitive surgical solution in the secondary level being preventive at primary level. Universe was comprised of all the children suffering from conductive hypoakusia who were recorded in the auditory care office, the sample had 109 patients coming from 10 municipalities of our province and suffering from hipoakusia due to serous otitis media secondary to adenoid hypertrophia, they were 4 and 12 year old. All the patients were given otolaringologic examinations and tonal audiometry. Survey methods, documental analisis and descriptive statistic method were applied using relative and absolute percentage frequency measurements.Confidence intervals for some relative frequencies and previous informed consent were estimated; patients were surgically treated and reevaluated at the office showing that 108 patients had a satisfactory natural history and concluding that it is an efficient technique.

Fidel Castro Pérez; Amaelis Arada Rodríguez; José G Sanabria Negrín; Antonio Paz Cordobés

2008-01-01

227

Modalidad quirúrgica como alternativa en la otitis media serosa por hipertrofia adenoidea: Pinar del Río, 2008/ An alternative surgical method in the serous otitis media due to adenoid hypertrophia: Pinar del Rio, 2008  

Scientific Electronic Library Online (English)

Full Text Available Abstract in spanish La hipoacusia tiene repercusión negativa en el aprendizaje y comportamiento social de los niños, por lo que se hace necesaria la aplicación de técnicas quirúrgicas cada día más eficientes que reduzcan esta problemática. Con el objetivo de demostrar la eficacia de una nueva modalidad quirúrgica consistente en realizar adenoidectomía y doble miringotomía con aspiración del contenido seromucoso y de proponer una estrategia para solución quirúrgica definitiva en (more) el nivel secundario y preventiva en el nivel primario, se realizó una investigación de innovación _ tecnológica, descriptiva, longitudinal prospectiva en niños con hipoacusia conductiva por otitis media serosa secundaria a hipertrofia adenoidea, que asistieron a las consultas de audiología del Hospital Pediátrico Provincial Docente" Pepe Portilla" y del Policlínico Universitario Dr." Ernesto Guevara" de Sandino. El universo estuvo constituido por todos los niños con hipoacusia conductiva registrados en consulta de audiología. La muestra resultó de 109 pacientes con hipoacusia por Otitis Media Serosa secundaria a Hipertrofia Adenoidea, provenientes de 10 municipios de nuestra provincia, entre los 4 y 12 años de edad; mediante muestreo intencional. A todos los pacientes se les realizó examen otorrinolaringológico y audiometría tonal. Se utilizaron métodos de encuesta, análisis documental y de la Estadística Descriptiva utilizando medidas de frecuencias absolutas y relativas porcentuales. Se calcularon intervalos de confianza para algunas de las frecuencias relativas buscadas y previo consentimiento informado se trataron quirúrgicamente, reevaluados en consulta, donde se comprobó que 108 pacientes evolucionaron satisfactoriamente, concluyendo que es una técnica eficaz. Abstract in english Hypoakusia has a negative repercussion in learning and social behaviour in children so it is mandatory the implementation of surgical techniques in order to minimize this condition.. A new descriptive longitudinal and prospective technique was performed in children suffering from conductive hypoakusia due to serous otitis media secondary to adenoid hypertrophia attending to the hearing care office at "Pepe Portilla"Pediatric Hospital and "Dr.Ernesto Guevara "Policlinic in (more) Sandino in order to show the efficacy of a new definitive surgical technique (adenotomy and double miringotomy with aspiration of the seromucus content ) and to propose an strategy for a definitive surgical solution in the secondary level being preventive at primary level. Universe was comprised of all the children suffering from conductive hypoakusia who were recorded in the auditory care office, the sample had 109 patients coming from 10 municipalities of our province and suffering from hipoakusia due to serous otitis media secondary to adenoid hypertrophia, they were 4 and 12 year old. All the patients were given otolaringologic examinations and tonal audiometry. Survey methods, documental analisis and descriptive statistic method were applied using relative and absolute percentage frequency measurements.Confidence intervals for some relative frequencies and previous informed consent were estimated; patients were surgically treated and reevaluated at the office showing that 108 patients had a satisfactory natural history and concluding that it is an efficient technique.

Castro Pérez, Fidel; Arada Rodríguez, Amaelis; Sanabria Negrín, José G; Paz Cordobés, Antonio

2008-12-01

228

Optimization of radiation therapy for locally advanced adenoid cystic carcinomas with infiltration of the skull base using photon intensity-modulated radiation therapy (IMRT) and a carbon ion boost  

International Nuclear Information System (INIS)

Background: Tumor doses > 70 Gy are needed for local control in adenoid cystic carcinomas. These tumor doses cannot be delivered if the tolerance doses to neighboring organs at risk (OAR) are respected. This treatment planning study investigates the physical advantage of combined photon intensity-modulated radiation therapy (IMRT) plus carbon ion boost compared to photon IMRT alone. Patients and Methods: For nine patients, treatment plans were generated using a) photon IMRT alone (integrated boost concept), and b) sum plans consisting of a photon IMRT plan and a carbon ion boost plan. 54 Gy were prescribed to the planning target volume 1 (PTV1), the boost volume (PTV2) received 72 Gy. The tolerance doses of the delineated OAR were strictly adhered to. Plan quality of IMRT plans and sum plans was compared using adequate physical parameters. Results: Both therapy techniques lead to highly conformal dose distributions that allow the prescription of the desired target doses. Target conformality and heterogeneity as well as target coverage for PTV1 are comparable for both techniques. The target coverage for PTV2 can be significantly improved using carbon ion beams (median 95% coverage 93.7% vs 87%; p = 0.039). Furthermore, the mean doses to the OAR can be reduced by 8.3% (median % reduction of mean doses to OAR; p = 0.00001) using carbon ions. Conclusions: The combination of photon IMRT with carbon ions improves the target coverage for the boost volume and offers better sparing of OAR close to the PTV2 (gross tumor volume) in comparison with photon IMRT alone. A clinical study has been initiated to evaluate whether these potential advantages translate into clinical benefit. (orig.)

2003-01-01

229

Inverse planned stereotactic intensity modulated radiotherapy (IMRT) in the treatment of incompletely and completely resected adenoid cystic carcinomas of the head and neck: initial clinical results and toxicity of treatment  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background Presenting the initial clinical results in the treatment of complex shaped adenoid cystic carcinomas (ACC) of the head and neck region by inverse planned stereotactic IMRT. Materials 25 patients with huge ACC in different areas of the head and neck were treated. At the time of radiotherapy two patients already suffered from distant metastases. A complete resection of the tumor was possible in only 4 patients. The remaining patients were incompletely resected (R2: 20; R1: 1). 21 patients received an integrated boost IMRT (IBRT), which allow the use of different single doses for different target volumes in one fraction. All patients were treated after inverse treatment planning and stereotactic target point localization. Results The mean folllow-up was 22.8 months (91 – 1490 days). According to Kaplan Meier the three year overall survival rate was 72%. 4 patients died caused by a systemic progression of the disease. The three-year recurrence free survival was according to Kaplan Meier in this group of patients 38%. 3 patients developed an in-field recurrence and 3 patient showed a metastasis in an adjacent lymph node of the head and neck region. One patient with an in-field recurrence and a patient with the lymph node recurrence could be re-treated by radiotherapy. Both patients are now controlled. Acute side effects >Grade II did only appear so far in a small number of patients. Conclusion The inverse planned stereotactic IMRT is feasible in the treatment of ACC. By using IMRT, high control rates and low side effects could by achieved. Further evaluation concerning the long term follow-up is needed. Due to the technical advantage of IMRT this treatment modality should be used if a particle therapy is not available.

Münter MW; Schulz-Ertner D; Hof H; Nikoghosyan A; Jensen A; Nill S; Huber P; Debus J

2006-01-01

230

Optimization of radiation therapy for locally advanced adenoid cystic carcinomas with infiltration of the skull base using photon intensity-modulated radiation therapy (IMRT) and a carbon ion boost.  

UK PubMed Central (United Kingdom)

BACKGROUND: Tumor doses > 70 Gy are needed for local control in adenoid cystic carcinomas. These tumor doses cannot be delivered if the tolerance doses to neighboring organs at risk (OAR) are respected. This treatment planning study investigates the physical advantage of combined photon intensity-modulated radiation therapy (IMRT) plus carbon ion boost compared to photon IMRT alone. PATIENTS AND METHODS: For nine patients, treatment plans were generated using a) photon IMRT alone (integrated boost concept), and b) sum plans consisting of a photon IMRT plan and a carbon ion boost plan. 54 Gy were prescribed to the planning target volume 1 (PTV1), the boost volume (PTV2) received 72 Gy. The tolerance doses of the delineated OAR were strictly adhered to. Plan quality of IMRT plans and sum plans was compared using adequate physical parameters. RESULTS: Both therapy techniques lead to highly conformal dose distributions that allow the prescription of the desired target doses. Target conformality and heterogeneity as well as target coverage for PTV1 are comparable for both techniques. The target coverage for PTV2 can be significantly improved using carbon ion beams (median 95% coverage 93.7% vs 87%; p = 0.039). Furthermore, the mean doses to the OAR can be reduced by 8.3% (median % reduction of mean doses to OAR; p = 0.00001) using carbon ions. CONCLUSIONS: The combination of photon IMRT with carbon ions improves the target coverage for the boost volume and offers better sparing of OAR close to the PTV2 (gross tumor volume) in comparison with photon IMRT alone. A clinical study has been initiated to evaluate whether these potential advantages translate into clinical benefit.

Schulz-Ertner D; Didinger B; Nikoghosyan A; Jäkel O; Zuna I; Wannenmacher M; Debus J

2003-05-01

231

Optimization of radiation therapy for locally advanced adenoid cystic carcinomas with infiltration of the skull base using photon intensity-modulated radiation therapy (IMRT) and a carbon ion boost  

Energy Technology Data Exchange (ETDEWEB)

Background: Tumor doses > 70 Gy are needed for local control in adenoid cystic carcinomas. These tumor doses cannot be delivered if the tolerance doses to neighboring organs at risk (OAR) are respected. This treatment planning study investigates the physical advantage of combined photon intensity-modulated radiation therapy (IMRT) plus carbon ion boost compared to photon IMRT alone. Patients and Methods: For nine patients, treatment plans were generated using a) photon IMRT alone (integrated boost concept), and b) sum plans consisting of a photon IMRT plan and a carbon ion boost plan. 54 Gy were prescribed to the planning target volume 1 (PTV1), the boost volume (PTV2) received 72 Gy. The tolerance doses of the delineated OAR were strictly adhered to. Plan quality of IMRT plans and sum plans was compared using adequate physical parameters. Results: Both therapy techniques lead to highly conformal dose distributions that allow the prescription of the desired target doses. Target conformality and heterogeneity as well as target coverage for PTV1 are comparable for both techniques. The target coverage for PTV2 can be significantly improved using carbon ion beams (median 95% coverage 93.7% vs 87%; p = 0.039). Furthermore, the mean doses to the OAR can be reduced by 8.3% (median % reduction of mean doses to OAR; p = 0.00001) using carbon ions. Conclusions: The combination of photon IMRT with carbon ions improves the target coverage for the boost volume and offers better sparing of OAR close to the PTV2 (gross tumor volume) in comparison with photon IMRT alone. A clinical study has been initiated to evaluate whether these potential advantages translate into clinical benefit. (orig.)

Schulz-Ertner, D.; Wannenmacher, M. [Dept. of Radiation Oncology, Univ. of Heidelberg (Germany); Didinger, B.; Nikoghosyan, A.; Zuna, I. [Div. of Radiation Oncology, German Cancer Research Center (DKFZ) Heidelberg (Germany); Jaekel, O. [Div. of Medical Physics, German Cancer Research Center (DKFZ) Heidelberg (Germany); Debus, J. [Dept. of Radiation Oncology, Univ. of Heidelberg (Germany); Div. of Radiation Oncology, German Cancer Research Center (DKFZ) Heidelberg (Germany)

2003-05-01

232

Análise quantitativa das AgNORs no carcinoma adenóide cístico intra-oral através da técnica de dupla marcação PCNA/AgNOR PCNA/AgNOR double staining technique in adenoid cystic carcinoma  

Directory of Open Access Journals (Sweden)

Full Text Available A análise quantitativa das AgNORs e a imunomarcação para o PCNA têm sido empregadas de forma independente na avaliação da proliferação celular de vários tumores, e, em muitos casos, têm mostrado correlação positiva. Entretanto poucos trabalhos têm avaliado, em um mesmo corte histológico, a relação entre PCNA e AgNOR. O objetivo deste trabalho foi otimizar a técnica de dupla marcação com a finalidade de se estudar simultaneamente a correlação entre PCNA e AgNOR no carcinoma adenóide cístico (CAC) de glândulas salivares menores. Foram selecionados 16 casos de CAC classificados de acordo com o subtipo histológico. A análise quantitativa das AgNORs foi feita por meio de análise de imagens. As AgNORs foram contadas em cem núcleos PCNA positivos e em cem núcleos PCNA negativos. O número médio de AgNOR nos núcleos PCNA positivos foi 2,14 ± 0,77, e, nos núcleos PCNA negativos, 1,97 ± 0,79, entretanto esta diferença não se mostrou estatisticamente significante (p = 0,2537). Nosso trabalho não mostrou correlação entre o número de AgNOR e a imunomarcação para o PCNA em CAC quando estes marcadores foram demonstrados simultaneamente através da dupla marcação. Quanto à técnica, o uso do microondas melhorou a coloração da AgNOR, permitindo uma redução no tempo de incubação com a solução de prata e uma melhor individualização das AgNORs, o que facilitou os procedimentos de contagem.No previous studies have simultaneously assessed the relationship between AgNORs and PCNA expression in salivary gland tumors. We describe a method to demonstrate both PCNA and AgNORs in the same slice of routinely processed tissue. We also evaluated the effect of microwaving on the AgNORs reaction. Sixteen cases of adenoid cystic carcinoma (ACC) were selected and the double staining technique was performed in order to quantify the number of AgNORs in PCNA-positive and negative cells. The best results were obtained when AgNOR was performed after the immunostaining. The microwave oven heating improved the AgNORs staining. Our results did not show a statistical difference between the mean number of AgNORs in PCNA-negative and positive cells. There is no association between PCNA and AGNOR in ACC when they are assessed by double-staining.

Elena Riet-Correa Rivero; Maria Cássia Ferreira de Aguiar

2002-01-01

233

Análise quantitativa das AgNORs no carcinoma adenóide cístico intra-oral através da técnica de dupla marcação PCNA/AgNOR/ PCNA/AgNOR double staining technique in adenoid cystic carcinoma  

Scientific Electronic Library Online (English)

Full Text Available Abstract in portuguese A análise quantitativa das AgNORs e a imunomarcação para o PCNA têm sido empregadas de forma independente na avaliação da proliferação celular de vários tumores, e, em muitos casos, têm mostrado correlação positiva. Entretanto poucos trabalhos têm avaliado, em um mesmo corte histológico, a relação entre PCNA e AgNOR. O objetivo deste trabalho foi otimizar a técnica de dupla marcação com a finalidade de se estudar simultaneamente a correlação entre PCN (more) A e AgNOR no carcinoma adenóide cístico (CAC) de glândulas salivares menores. Foram selecionados 16 casos de CAC classificados de acordo com o subtipo histológico. A análise quantitativa das AgNORs foi feita por meio de análise de imagens. As AgNORs foram contadas em cem núcleos PCNA positivos e em cem núcleos PCNA negativos. O número médio de AgNOR nos núcleos PCNA positivos foi 2,14 ± 0,77, e, nos núcleos PCNA negativos, 1,97 ± 0,79, entretanto esta diferença não se mostrou estatisticamente significante (p = 0,2537). Nosso trabalho não mostrou correlação entre o número de AgNOR e a imunomarcação para o PCNA em CAC quando estes marcadores foram demonstrados simultaneamente através da dupla marcação. Quanto à técnica, o uso do microondas melhorou a coloração da AgNOR, permitindo uma redução no tempo de incubação com a solução de prata e uma melhor individualização das AgNORs, o que facilitou os procedimentos de contagem. Abstract in english No previous studies have simultaneously assessed the relationship between AgNORs and PCNA expression in salivary gland tumors. We describe a method to demonstrate both PCNA and AgNORs in the same slice of routinely processed tissue. We also evaluated the effect of microwaving on the AgNORs reaction. Sixteen cases of adenoid cystic carcinoma (ACC) were selected and the double staining technique was performed in order to quantify the number of AgNORs in PCNA-positive and ne (more) gative cells. The best results were obtained when AgNOR was performed after the immunostaining. The microwave oven heating improved the AgNORs staining. Our results did not show a statistical difference between the mean number of AgNORs in PCNA-negative and positive cells. There is no association between PCNA and AGNOR in ACC when they are assessed by double-staining.

Rivero, Elena Riet-Correa; Aguiar, Maria Cássia Ferreira de

2002-01-01

234

Effect of a nitric oxide synthase inhibitor and a CXC chemokine receptor-4 antagonist on tumor growth and metastasis in a xenotransplanted mouse model of adenoid cystic carcinoma of the oral floor.  

Science.gov (United States)

Nitric oxide (NO) is related to angiogenesis and tumor progression and chemokine receptor-4 (CXCR4) plays a central role in cell migration in metastasis and dissemination of cancer. The present study evaluated the effectiveness of a NOS inhibitor and a CXCR4 antagonist, given as single agents or in combination, in a xenotransplanted mouse model of adenoid cystic carcinoma (ACC) of the oral floor. A metastatic tumor (ACCIM) derived from a cervical metastatic lesion of human ACC that was transplantable in nude mice was used. ACCIM showed a high frequency of spontaneous metastasis to the lung when transplanted subcutaneously in nude mice. Mice with subcutaneous transplants of ACCIM were subdivided into six groups and intraperitoneally received one of the following treatments daily for 5 weeks: a) PBS (control), b) AMD3100 (CXCR4 antagonist), c) L-NAME (NOS inhibitor), d) 1400W (iNOS inhibitor), e) both AMD3100 and L-NAME (AMD3100+L-NAME) and f) both AMD3100 and 1400W (AMD3100+1400W). Tumor growth was evaluated during treatment and metastasis was assessed at 28 weeks. Single-agent treatment with AMD3100, L-NAME or 1400W inhibited tumor growth by 20.8, 26.5 and 54.5%, respectively. Combined treatment with AMD3100+L-NAME and AMD3100+1400W inhibited tumor growth remarkably by 48.0 and 50.2%, respectively. Immunohistochemical analysis revealed lower expression of CXCR4, iNOS and eNOS in tumor cells treated with AMD3100+L-NAME or AMD3100+1400W compared to control tumor cells and increased numbers of apoptotic tumor cells were demonstrated using the TUNEL method. CXCR4 expression decreased in 1400W-treated tumors using western blot analysis. When the effect of each agent on tumor-induced angiogenesis in tumor stroma was examined histologically, microvessel density was significantly lower in the groups treated with 1400W, AMD3100+L-NAME or AMD3100+1400W compared to the control, AMD3100 and L-NAME groups. Moreover, treatment with AMD3100 or 1400W markedly inhibited lung metastasis. Our results indicated that single-agent treatment with 1400W and combined treatment with AMD3100+L-NAME or AMD3100+1400W induced apoptosis and significantly inhibited tumor-induced angiogenesis and proliferation of ACCIM in vivo. Blockade of CXCR4 and iNOS was suggested to inhibit lung metastases from ACCIM. CXCR4 and iNOS may, thus, be important prognostic factors for long-term survival in ACC. PMID:23835861

Takaoka, Kazuki; Hidaka, Sayaka; Hashitani, Susumu; Segawa, Emi; Yamamura, Michiyo; Tanaka, Noriaki; Zushi, Yusuke; Noguchi, Kazuma; Kishimoto, Hiromitsu; Urade, Masahiro

2013-07-08

235

Effect of a nitric oxide synthase inhibitor and a CXC chemokine receptor-4 antagonist on tumor growth and metastasis in a xenotransplanted mouse model of adenoid cystic carcinoma of the oral floor.  

UK PubMed Central (United Kingdom)

Nitric oxide (NO) is related to angiogenesis and tumor progression and chemokine receptor-4 (CXCR4) plays a central role in cell migration in metastasis and dissemination of cancer. The present study evaluated the effectiveness of a NOS inhibitor and a CXCR4 antagonist, given as single agents or in combination, in a xenotransplanted mouse model of adenoid cystic carcinoma (ACC) of the oral floor. A metastatic tumor (ACCIM) derived from a cervical metastatic lesion of human ACC that was transplantable in nude mice was used. ACCIM showed a high frequency of spontaneous metastasis to the lung when transplanted subcutaneously in nude mice. Mice with subcutaneous transplants of ACCIM were subdivided into six groups and intraperitoneally received one of the following treatments daily for 5 weeks: a) PBS (control), b) AMD3100 (CXCR4 antagonist), c) L-NAME (NOS inhibitor), d) 1400W (iNOS inhibitor), e) both AMD3100 and L-NAME (AMD3100+L-NAME) and f) both AMD3100 and 1400W (AMD3100+1400W). Tumor growth was evaluated during treatment and metastasis was assessed at 28 weeks. Single-agent treatment with AMD3100, L-NAME or 1400W inhibited tumor growth by 20.8, 26.5 and 54.5%, respectively. Combined treatment with AMD3100+L-NAME and AMD3100+1400W inhibited tumor growth remarkably by 48.0 and 50.2%, respectively. Immunohistochemical analysis revealed lower expression of CXCR4, iNOS and eNOS in tumor cells treated with AMD3100+L-NAME or AMD3100+1400W compared to control tumor cells and increased numbers of apoptotic tumor cells were demonstrated using the TUNEL method. CXCR4 expression decreased in 1400W-treated tumors using western blot analysis. When the effect of each agent on tumor-induced angiogenesis in tumor stroma was examined histologically, microvessel density was significantly lower in the groups treated with 1400W, AMD3100+L-NAME or AMD3100+1400W compared to the control, AMD3100 and L-NAME groups. Moreover, treatment with AMD3100 or 1400W markedly inhibited lung metastasis. Our results indicated that single-agent treatment with 1400W and combined treatment with AMD3100+L-NAME or AMD3100+1400W induced apoptosis and significantly inhibited tumor-induced angiogenesis and proliferation of ACCIM in vivo. Blockade of CXCR4 and iNOS was suggested to inhibit lung metastases from ACCIM. CXCR4 and iNOS may, thus, be important prognostic factors for long-term survival in ACC.

Takaoka K; Hidaka S; Hashitani S; Segawa E; Yamamura M; Tanaka N; Zushi Y; Noguchi K; Kishimoto H; Urade M

2013-09-01

236

Nasopharyngeal carcinomas: from biology to clinic; Les carcinomes du nasopharynx: de la biologie a la clinique  

Energy Technology Data Exchange (ETDEWEB)

Nasopharyngeal carcinomas (NPC) are very different from other head and neck cancers because of their specific multi-factorial etiology and their geographic distribution. Epstein-Barr Virus (EBV) is implicated in onco-genesis of NPC in association with genetic alterations such as inactivation of the p16/Ink4, p19/ARF, RASSFI or Blu genes. Tumoral tissues include a very abundant characteristic lymphoid infiltrate. Inflammatory cytokines are produced by both malignant and infiltrating cells. There is no efficient immune response against the tumor. On the opposite, infiltrating lymphocytes might play a role in tumor development. Serological methods and detection of circulating viral DNA are expected to become useful for early detection of relapse and on a longer term for primary screening. NPC are often diagnosed at a late stage because patients may remain asymptomatic for a long time. Computed tomography (CT scan) and magnetic resonance imaging (MRI) are complementary for the initial evaluation. Positron emission tomography (PET) is efficient for the evaluation of treatment efficiency and detection of relapses. Treatment is based on radiotherapy and chemotherapy. Their optimal use needs to be evaluated by phase III trials but positive results have been obtained by concomitant association of radiotherapy and chemotherapy. Targeted therapies are being studied with strategies based on disruption of viral latency, use of replicative adeno-viruses or anti-tumor vaccination. (author)

Rivera, S.; Maingon, P. [Centre Georges-Francois-Leclerc, Dept. de Radiotherapie, 21 - Dijon (France); Keryer, C.; Busson, P. [Institut Gustave-Roussy, CNRS/UMR 8126, 94 - Villejuif (France)

2005-02-15

237

Late neurotoxicity after nasopharyngeal carcinoma treatment;Toxicite neurologique tardive apres traitement des carcinomes nasopharynges  

Energy Technology Data Exchange (ETDEWEB)

Purpose A retrospective analysis of risk factors for late neurological toxicity after nasopharyngeal carcinoma radiotherapy. Patients and methods Between 1993 and 2004, 239 patients with non metastatic nasopharyngeal carcinoma were treated by radiotherapy associated or not to chemotherapy. Radiotherapy was delivered with two modalities: hyperfractionated for 82 patients and conventional fractionation for 157 patients. We evaluated the impact of tumour stage, age, gender, radiotherapy schedule and chemotherapy on neurological toxicity. Results After a mean follow-up of 107 months (35-176 months), 21 patients (8.8%) developed neurological complications, such as temporal necrosis in nine cases, brain stem necrosis in five cases, optics nerve atrophy in two cases and myelitis in one case. Five- and ten-year free of toxicity survival was 95 and 84% respectively. Young patients had greater risk of temporal necrosis, and hyperfractionated radiotherapy was associated with a significantly higher risk of neurological complications (14.6% vs 5.7%, p = 0.02). On multivariate analysis, hyperfractionation and age were insignificant. Conclusion Late neurological toxicity after radiotherapy for nasopharyngeal carcinoma was rare. Younger age and hyperfractionation were considered as risk factors of neurological toxicity in our study

Siala, W.; Mnejja, W.; Daoud, J. [Hopital Habib-Bourguiba, Service de Radiotherapie Carcinologique, Sfax (Tunisia); Khabir, A.; Boudawara, T. [Hopital Habib-Bourguiba, Service d' Anatomopathologie, Sfax (Tunisia); Ben Mahfoudh, K. [Hopital Habib-Bourguiba, Service de Radiologie, Sfax (Tunisia); Ghorbel, A. [Hopital Habib-Bourguiba, Service d' ORL, Sfax (Tunisia); Frikha, M. [Hopital Habib-Bourguiba, Service de Carcinologie Medicale, Sfax (Tunisia)

2009-12-15

238

Therapy of metastasized differentiated thyroid carcinoms; Therapie des metastasierten differenzierten Schilddruesenkarzinoms  

Energy Technology Data Exchange (ETDEWEB)

Therapy with radioiodine is the only curative option in differentiated metastasized thyroid carcinoma (subsequent to surgical intervention). Therapy in case of metatases is of particular relevance in patients with thyroid carcinoma of stage pT4, i.e. in case of expansive growth, as this stage is characterized by frequent hematogenous dissemination of tumor cells. As to histology there are prognostic differences: Follicular thyroid carcinomas are more frequently associated with osseous metastases than papillary carcinomas, and osseous metastases can only be successfully treated in a relatively small percentage. In cases of initial osseous metastases, however, the results of radioiodine therapy are more promising. Compared with delayed development of osseous metastases, initial metastases show significantly radioiodine uptake on average. To date, it has been clarified that there are good chances to cure patients with initial bone metastases by consequent high-dose radioiodine therapy, contrary to wide-spread opinion. Apart from radioiodine uptake, tumor stage, histology, and location of metastases, the patient's age at manifestation of disease is a further prognostic factor when treating metastases of the differentiated thyroid carcinoma. The potential of therapy is limited by hematoxicity when the dose administered exceeds 50-100 GBq. Alternative modalities of therapy like external radiation or chemotherapy by itself or combined with radiation are not sufficiently effective until now. Recently developed therapeutic concepts are still in an experimental stage. After a period of stagnation in methodological development of radioiodine therapy, modifications of treatment modalities (e.g., by combining external radiation with chemotherapy, by applying retinoids or rhTSH etc.) are being evaluated. (orig./MG) [German] Die Radiojodtherapie (RJT) ist derzeit die einzige Behandlungsform mit kurativem Ansatz beim differenzierten metastasierten SD-Karzinom (nach vorangegangener chirurgischer Intervention). Diese therapeutische Option kommt vor allem Patienten mit organueberschreitendem Wachstum des Primaertumors zugute, da im pT4-Stadium eine haematogene Metastasierung besonders haeufig ist. Hinsichtlich der Histologie bestehen prognostische Unterschiede insofern, als follikulaere SD-Karzinome haeufiger ossaer metastasieren als papillaere Karzinome, und ossaere Metastasen durch RJT seltener kurativ behandelt werden koennen. Guenstiger sind die Ergebnisse der RJT bei der Behandlung initialer ossaerer Metastasen, die im Vergleich zu spaeter auftretenden ossaeren Metastasen eine signifikant hoehere RJ-Aufnahme und -Speicherung aufweisen. Es ist inzwischen eindeutig belegt, dass durch eine konsequente hochdosierte RJT insbesondere bei Patienten mit initialen Knochenmetastasen (entgegen weitverbreiteter Meinung) gute Heilungschancen bestehen. Neben der RJ-Speicherung, dem Tumorstadium, der Histologie und der Lokalisation der Metastasen ist das Alter des Patienten bei Erstdiagnose ein weiterer prognostischer Faktor bei der Behandlung von Metastasen des differenzierten SD-Karzinoms. Limitiert wird die RJT durch die Haematotoxizitaet, die vor allem ab einer Aktivitaet von 50-100 GBq besonders zum Ausdruck kommt. Andere Therapieformen, wie z.B. Radiatio, Chemotherapie allein oder als Kombinationsbehandlung, sind bislang nicht zufriedenstellend wirksam. Neuere Behandlungskonzepte sind noch im experimentellen Stadium. Nach einer laengeren Phase des methodischen Entwicklungsstillstandes der RJT zeichnen sich nun Veraenderungen der Behandlungsmodalitaeten (z.B. durch Kombination mit externer Radiatio und Chemotherapie, durch Einsatz von Retinioden und rhTSH etc.) ab, die zu einer weiteren Verbesserung der Ergebnisse fuehren bzw. das Spektrum der behandelbaren Patienten erweitern koennten. (orig./MG)

Petrich, T.; Knapp, W.H. [Medizinische Hochschule Hannover (Germany). Klinik fuer Nuklearmedizin

2000-03-01

239

Sorafenib and radiotherapy association for hepatocellular carcinoma; Sorafenib et radiotherapie dans le carcinome hepatocellulaire  

Energy Technology Data Exchange (ETDEWEB)

Conformal radiotherapy is a promising therapeutic strategy for hepatocellular carcinoma (HCC), producing local control rates above 90% within the radiation beam. However, survival after radiotherapy remains limited by the high frequency of intra- and extra-hepatic recurrences, which occurs in 40-50 and 20-30% of cases, respectively. Sorafenib (BAY43-9006, Nexavar; Bayer, West Haven, CT) is a small molecule inhibitor that demonstrated potent activity to target v-raf murine sarcoma oncogene homologue B1 (BRAF) and VEGFR tyrosine kinases. Sorafenib is the only drug that demonstrated effectiveness to increase overall survival in advanced or metastatic hepatocellular carcinoma. The rationale to combine radiotherapy with sorafenib is the following: (1) targeting RAS-RAF-MAPK and VEGFR signaling pathways, which are specifically activated after exposure to radiation, and responsible for radio-resistance phenomenon; (2) enhancing the oxygen effect through normalization of the surviving tumor vasculature; and (3) synchronization of the cell cycle. Sorafenib and radiotherapy represent complementary strategies, as radiotherapy may be useful to prolong the effect of sorafenib through control of the macroscopic disease, when sorafenib may target latent microscopic disease. Sorafenib and radiotherapy associations are thus based on a relevant biological and clinical rationale and are being evaluated in ongoing phase I-II trials. (authors)

Girard, N. [Service de pneumologie, hopital Louis-Pradel, hospices Civils de Lyon, 28, avenue du Doyen-Jean-Lepine, 69500 Bron (France); UMR 754, universite Claude-Bernard Lyon 1, 43, boulevard du 11-novembre-1918, 69622 Villeurbanne cedex (France); Mornex, F. [UMR 754, universite Claude-Bernard Lyon 1, 43, boulevard du 11-novembre-1918, 69622 Villeurbanne cedex (France); Departement de radiotherapie-oncologie, centre hospitalier Lyon Sud, 165, chemin du Grand-Revoyet, 69495 Pierre-Benite cedex (France)

2011-02-15

240

Irradiation of low rectal cancers; Radiotherapie des carcinomes du bas rectum  

Energy Technology Data Exchange (ETDEWEB)

The low rectal cancers are treated by anorectal amputation and pose the problem of the sphincter conservation. Some authors extend the clinical definition to developed injuries until 12 cm from the anal margin. The rectal cancer is a frequent tumour which remains serious. When the tumour is low, the treatment consists in an anorectal amputation with a permanent colostomy. The radical non preserving surgery is the usual treatment of these injuries. Until 1960 the rectal adenocarcinoma was considered as a radioresistant tumour because of the impossibility to deliver an enough dose to the tumour by external radiotherapy. But other studies showed that those lesions were radiosensitive and often radiocurable. The medical treatments haven`t yet demonstrated their efficiency in the treatment of the rectal cancer. We`ll study the radiotherapy in the treatment of the low rectal cancer, solely radiotherapy, radiosurgical associations. 32 refs., 5 tabs.

Ardiet, J.M.; Coquard, R.; Romestaing, P.; Fric, D.; Baron, M.H.; Rocher, F.P.; Sentenac, I.; Gerard, J.P. [Centre Hospitalier Lyon-Sud, 69 -Pierre-Benite (France)

1994-12-31

 
 
 
 
241

The evolving role of radiation therapy in hepatocellular carcinoma; Place de la radiotherapie dans le carcinome hepatocellulaire  

Energy Technology Data Exchange (ETDEWEB)

Technical advancements in imaging, in radiation therapy (R.T.) planning and R.T. delivery, have facilitated the safe delivery of conformal radiation therapy to patients with unresectable hepatocellular carcinoma (H.C.C.). Although experience in liver cancer R.T. is limited, the R.T. technologies and tools to deliver R.T. safely are being disseminated rapidly. A variety of doses and R.T. fractionations have been used to treat H.C.C., and R.T. has been used in combination with other therapies including trans arterial hepatic chemo embolization (T.A.C.E.). Outcomes following R.T. alone or R.T. and T.A.C.E. appear better than outcomes following similar historical controls of T.A.C.E. alone, however, randomized trials of R.T. are needed. The first site of recurrence following R.T. is most often within the liver, away from the high dose volume, providing rationale for combining R.T. with regional or systemic therapies. Given the vascular properties of H.C.C., the combination of R.T. with anti-V.E.G.F. targeted agents may improve outcomes further. (author)

Dawson, L.A. [Toronto Univ., Dept. of Radiation Oncology, Princess Margaret Hospital, Ontario (Canada)

2008-03-15

242

Traitement des carcinomes hépatocellulaires à un stade avancé Treatment of unresectable hepatocellular carcinoma at an intermediate or advanced stage  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Hepatocellular carcinoma is the main primitive tumor of the liver. It occurs in the setting of liver cirrhosis in more than 90% of the cases in developping countries. The prognosis depends on the size, number and extension of the tumor as well as on the severity of the underlying liver disease. The ...

Van Daele, Daniel; Belaiche, Jacques; Delwaide, Jean; Piront, Patricia; De Roover, Arnaud; Detry, Olivier; Honore, Pierre

243

Squamous cell carcinoma complicating an hereditary epidermo-lysis bullosa; Carcinome spinocellulaire compliquant une epidermolyse bulleuse hereditaire  

Energy Technology Data Exchange (ETDEWEB)

The dystrophic form of hereditary epidermo-lysis bullosa is associated with an increased frequency of squamous cell carcinoma. We report a new case. An 18-year-old patient, carrying a Hallopeau Siemens hereditary epidermo-lysis bullosa, presented a subcutaneous nodular lesion, for 1 year that ulcerated and budded with inguinal lymphadenopathy. The histological study ted to the conclusion of a well differentiated squamous cell carcinoma. The patient was treated surgically. Tumor and metastatic lymph nodes were excised. A radiotherapy was decided but the postoperative course was fatal due to an infection and to a deterioration of her general condition. Squamous cell carcinoma frequently occurs on the cicatricial lesion of hereditary epidermo-lysis bullosa and usually affects males with recessive hereditary epidermo-lysis bullosa. Metastases are frequent, precocious and multiple. The treatment may be surgical. The particularities of our observation are the young age of patient and the localization. (author)

Mseddi, M.; Turki, H.; Marrekchi, S.; Abdelmaksoud, W.; Masmoudi, A.; Bouassida, S.; Zahaf, A. [Centre Hospitalier Universitaire Hedi Chaker, Service de Dermatologie, Sfax (Tunisia)

2004-08-01

244

Place of radiotherapy in tonsil carcinomas; Place de la radiotherapie dans les carcinomes de l`amygdale  

Energy Technology Data Exchange (ETDEWEB)

Oropharynx carcinomas are generally located at the level of palatine tonsil and are characterized by a great frequency of locally advanced steps. The radiotherapy keeps an important place in therapy. This has been demonstrated for a long time because the only surgery, maiming, could not be used in wide localizations. In fact, after the experience of 110 cases, exposed here, and with the comparison of others authors, it is concluded that radiotherapy must be used in first intention, surgery coming after it, only in compensation. (N.C.). 13 refs., 1 fig., 1 tab.

Sahraoui, S.; Acharki, A.; Samlali, R.; Benider, A.; Kahlain, A.

1995-12-31

245

Supra-scapular nerve entrapment by ganglion cyst. Value of imaging modalities; Compression kystique du nerf sus-scapulaire. Interet de l`imagerie. A propos de 6 cas et revue de la litterature  

Energy Technology Data Exchange (ETDEWEB)

Six cases of supra-scapular nerve entrapment by a ganglion cyst within the spino-glenoid notch or developed from the glenoid labrum are reported. Causes of injury or entrapment of the supra-scapular nerve are described including traction or kinking of the nerve, trauma, repetitive exercise, or compression by ganglion cyst. The patients had non specific pain, weakness, and atrophy of the spinatus musculature. Electromyography showed evidence of denervation atrophy. Patients had plain radiographs, arthrography, CT-arthrography, magnetic resonance imaging (MRI) and MR-arthrography. Masses that caused supra-scapular nerve entrapment were well localized and characterized with magnetic resonance imaging, reflecting the superior soft-tissue contrast of this modality. In addition, MRI may demonstrate atrophy of the spinatus muscles. MR-arthrography allows to visualize lesions of the glenoid labrum and in some cases, demonstrates cysts filling. (authors). 35 refs.

Levy, Ph.; Roger, B.; Tardieu, M.; Ghebontni, L.; Thelen, Ph.; Richard, O.; Grenier, Ph. [Hopital Pitie-Salpetriere, 75 - Paris (France)

1997-09-01

246

[Experimental study on co-culture of salivary adenoid cystic carcinoma cells and ganglia].  

UK PubMed Central (United Kingdom)

OBJECTIVE: To construct the co-culture models of salivarya denoid cystic carcinoma (SACC) cells and dorsal root ganglia (DRG) of chickens and investigate the promotive effects of SACC on neural tissue. METHODS: Glass-base culture dish was adopted to construct co-culture model of SACC-83 cells and DRG. SACC-83 cells were seeded in the medium pore with DRG around them. Outgrowth of neuronal processes was observed. Then DRG was cultured in the conditioned medium of SACC-83, with the groups of conditioned medium of MC3T3-E1 and HGF, the group of cell lysis buffer, the groups of serum-free medium and serum-plus medium as the controls. Outgrowth of neuronal processes was also recorded and compared with control groups. RESULTS: In the co-culture model of tumor and neuronal tissue, SACC-83 cells produced a suitable microenvironment in which neuronal processes remarkably grow. Neuronal processes of most DRG displayed growth tendency toward SACC. The group of conditioned medium from SACC-83 manifested obvious promotive effects on DRG. CONCLUSIONS: Co-culture model of tumor and neuronal tissue was successfully constructed, with which the promotive effects of tumor on outgrowth of neuronal processes could be observed. So hypothesized that SACC could secrete some neurotrophic factors to guide peripheral nerves gemmating and to trigger the cascade of the neural invasion in succession.

Gu L; Bu RF; Wang DS; E LL; Zhu GX

2012-01-01

247

Results of fast neutron therapy of adenoid cystic carcinoma of the salivary glands  

International Nuclear Information System (INIS)

72 consecutive patients with ACC were treated with fast neutrons, 66 after surgery, 6 for primarily unresectable disease, 43/66 for macroscopic residual disease, 23/66 for unresectable recurrent disease. 45/72 tumors were localized in the minor, 27 in the major salivary glands. T-stage was in 13 pts T2, in 33 T3, in 26 T4; positive nodes were in 10 pts. M+ in 15 pts. Mean tumor volume was 89 cm3. Neutron therapy was 15.03 Gy in 3 weeks with 1.67 Gy per fraction three times per week. Individual computer assisted treatment planning was performed based on CT and/or MRI, using bolus material if necessary. Target volume was the macroscopic tumor volume with a generous safety margin. Results: Complete response was achieved in 28 pts, partial response in 35 pts. Local control was observed in 73.4% after a mean observation period of 36 months. Overall and recurrence free survival was 85%/81% at two years, and 58%/53% at 5 years (Kaplan-Meier). In univariate analysis tumor volume (> 100 cm3), distant metastases, histologic subtype (solid) and neutron dose (

1999-01-01

248

Age influence on naso-pharynx carcinomas prognosis after chemoradiotherapy; Influence de l'age sur le pronostic des carcinomes nasopharynges apres chimioradiotherapie  

Energy Technology Data Exchange (ETDEWEB)

The recurrence modes were not different before and after seventy years. The conformal radiotherapy in classical fractionation can be realised for subjects over 70. The triplets are not easily used in chemotherapy of induction after 70 years, as the concomitant chemotherapy by cisplatin. The optimization perspectives include targeted therapies, and the lympho-therapy anti-Epstein-barr virus, especially in the aged subpopulations. (N.C.)

Thariat, J.; Peyrade, F.; Marcy, P.Y.; Guevara, N.; Dassonville, O.; Doglio, A.; Benezery, K.; Ortholan, C.; Bensadoun, R.J.; Santini, J. [Centre Antoine-Lacassagne, 06 - Nice (France)

2009-10-15

249

Von Hippel-Lindau and myotonic dystrophy of Steinert along with pancreatic neuroendocrine tumor and renal clear cell carcinomal neoplasm: Case report and review of the literature.  

UK PubMed Central (United Kingdom)

INTRODUCTION: Myotonic dystrophy of Steinert, DM1, is the most common adult muscular dystrophy and generally is not associated to development on multiple site neoplasm. Von Hippel-Lindau (VHL) disease is a dominantly inherited familial cancer syndrome that is associated to tumors such as hemangioblastoma of the retina or central nervous system, clear-cell renal carcinoma (RCC) and endocrine tumors, most commonly pheochromocytoma and non-secretory pancreatic islet cell cancers. No data exist in literature describing the coexistence of both DM1 and VHL. PRESENTATION OF CASE: Herein we report a case of renal and pancreatic neoplasm in a young adult female affected by DM1 and VHL simultaneously. DISCUSSION: DM1 is due to an unstable trinucleotide (CTG) expansion in the 30 antranslated region of the dystrophia myotonica-protein kinase (DMPK) gene, located on chromosome 19q13.3. Several molecular mechanisms thought to be determining the classical DM phenotype have been shown. VHL disease is characterized by marked phenotypic variability and the most common tumors are hemangioblastomas of the retina or central nervous system, clear-cell renal carcinoma (RCC) and endocrine tumors, most commonly pheochromocytoma and non-secretory pancreatic islet cell cancers. The pancreatic manifestations seen in patients with VHL disease are divided into 2 categories: pancreatic neuroendocrine tumor (PNET) as solid tumors, and cystic lesions, including a simple cyst and serous cystadenoma. The surgical approach for these cistic lesions is to consider as golden standard. Blansfield has proposed 3 criteria to predict metastatic disease of PNET in patients with VHL disease: (1) tumor size greater than or equal to 3cm; (2) presence of a mutation in exon 3; and (3) tumor doubling time less than 500d. If the patient has none of these criteria the patient could be followed with physical examination and radiological surveillance on a 2/3 years base.(4) If the patient has 1 criterion, the patient should be followed more closely every 6 months to 1 year. If the patient has 2 or 3 criteria, the patient should be considered for surgery given the high risk of future malignancy. Our patient owned only one criterion but in presence of a second malignant tumor. Our hypothesis for this rare findings is that both DM and VHL might be derived from genetic aberration and these might be linked to a major cancer susceptibility. As far as we know this is the first confirmed case of RCC and neuroendocrine pancreatic cancer occurring concurrently with VHL and, at the same time, DM1. According to this case report and the literature data a VHL should be ruled out in the presence of RCC presenting along with pancreatic cysts/tumor. CONCLUSION: As far as we know this is the first confirmed case of RCC and neuroendocrine pancreatic cancer occurring concurrently with VHL and, at the same time, DM1. Our hypothesis for the unusual findings is that both DM and VHL derived from genetic aberration and these are linked to a major cancer susceptibility.

Addeo A; Bini R; Viora T; Bonaccorsi L; Leli R

2013-01-01

250

Von Hippel-Lindau and myotonic dystrophy of Steinert along with pancreatic neuroendocrine tumor and renal clear cell carcinomal neoplasm: Case report and review of the literature  

Science.gov (United States)

INTRODUCTION Myotonic dystrophy of Steinert, DM1, is the most common adult muscular dystrophy and generally is not associated to development on multiple site neoplasm. Von Hippel-Lindau (VHL) disease is a dominantly inherited familial cancer syndrome that is associated to tumors such as hemangioblastoma of the retina or central nervous system, clear-cell renal carcinoma (RCC) and endocrine tumors, most commonly pheochromocytoma and non-secretory pancreatic islet cell cancers. No data exist in literature describing the coexistence of both DM1 and VHL. PRESENTATION OF CASE Herein we report a case of renal and pancreatic neoplasm in a young adult female affected by DM1 and VHL simultaneously. DISCUSSION DM1 is due to an unstable trinucleotide (CTG) expansion in the 30 antranslated region of the dystrophia myotonica-protein kinase (DMPK) gene, located on chromosome 19q13.3. Several molecular mechanisms thought to be determining the classical DM phenotype have been shown. VHL disease is characterized by marked phenotypic variability and the most common tumors are hemangioblastomas of the retina or central nervous system, clear-cell renal carcinoma (RCC) and endocrine tumors, most commonly pheochromocytoma and non-secretory pancreatic islet cell cancers. The pancreatic manifestations seen in patients with VHL disease are divided into 2 categories: pancreatic neuroendocrine tumor (PNET) as solid tumors, and cystic lesions, including a simple cyst and serous cystadenoma. The surgical approach for these cistic lesions is to consider as golden standard. Blansfield has proposed 3 criteria to predict metastatic disease of PNET in patients with VHL disease: (1) tumor size greater than or equal to 3 cm; (2) presence of a mutation in exon 3; and (3) tumor doubling time less than 500 d. If the patient has none of these criteria the patient could be followed with physical examination and radiological surveillance on a 2/3 years base.4 If the patient has 1 criterion, the patient should be followed more closely every 6 months to 1 year. If the patient has 2 or 3 criteria, the patient should be considered for surgery given the high risk of future malignancy. Our patient owned only one criterion but in presence of a second malignant tumor. Our hypothesis for this rare findings is that both DM and VHL might be derived from genetic aberration and these might be linked to a major cancer susceptibility. As far as we know this is the first confirmed case of RCC and neuroendocrine pancreatic cancer occurring concurrently with VHL and, at the same time, DM1. According to this case report and the literature data a VHL should be ruled out in the presence of RCC presenting along with pancreatic cysts/tumor. CONCLUSION As far as we know this is the first confirmed case of RCC and neuroendocrine pancreatic cancer occurring concurrently with VHL and, at the same time, DM1. Our hypothesis for the unusual findings is that both DM and VHL derived from genetic aberration and these are linked to a major cancer susceptibility.

Addeo, A.; Bini, R.; Viora, T.; Bonaccorsi, L.; Leli, R.

2013-01-01

251

COMPARISON AND EVALUATION OF VALUE OF THYROGLOBULIN LEVEL IN SERUM AND 1-131 WHOLE BODY SCAN (1-131 WBS) IN PATIENTS WITH DIFFERENTIATED THYROID CARCINOM  

Digital Repository Infrastructure Vision for European Research (DRIVER)

This study was done in research institute of nuclear medicine from 1988-1992 for evaluation of the value of serum thyroglobulin level in comparison with 1-131 whole body scan (1-131 WBS) in patients with differentiated thyroid carcinoma. 204 patients who had total or near total thyroidectomy treated...

A. Vakili; A.Fard . H. Mohadesi M. Eftekhari; M. Saghari

252

COMPARISON AND EVALUATION OF VALUE OF THYROGLOBULIN LEVEL IN SERUM AND 1-131 WHOLE BODY SCAN (1-131 WBS) IN PATIENTS WITH DIFFERENTIATED THYROID CARCINOM  

Directory of Open Access Journals (Sweden)

Full Text Available This study was done in research institute of nuclear medicine from 1988-1992 for evaluation of the value of serum thyroglobulin level in comparison with 1-131 whole body scan (1-131 WBS) in patients with differentiated thyroid carcinoma. 204 patients who had total or near total thyroidectomy treated with 1-131 were evaluated in this study. Out of 204 patients 136 did not have regional or distant metastases. 68 patients had recurrence and metastases in which 42 cases showed good correlation between hTG and 1-131 WBS. In 14 cases with recurrence and metastases only 1-131 WBS was diagnostic and in 12 cases hTG was diagnostic while 1-131 WBS was negative. With the help of other diagnostic modolities such as Tl-201, chest X-ray biopsy and repeated 1-131 WBS during 5 years of follow-up regional recurrence and metastases were diagnosed. Serum hTG level for diagnosis of recurrence and metastases hud a sensitivity of 79.4%, specificity 90.4% and accuracy of 86.8% while 1-131 WBS had sensitivity of 82.3%, accuracy of 94.1% and specificity of 100%.  

A. Vakili; A.Fard . H. Mohadesi M. Eftekhari; M. Saghari

1998-01-01

253

Amputación interescapulotorácica por cromomicosis y carcinoma epidermoide/ Interscapulothoracic amputation by chromomycosis and epidermoid carcinoma/ Amputation interscapulothracique pourchr4omomycose et6 carcinome épidermoide  

Scientific Electronic Library Online (English)

Full Text Available Abstract in spanish Paciente del sexo masculino y blanco de 74 años de edad, con lesión dermatológica hiperpigmentada y verrucosa de más de 25 años de evolución en codo y antebrazo izquierdo; asimismo posee otra de piel en forma de coliflor y cuya evolución es reciente. Ambas presentaron diagnóstico histopatológico de cromomicosis. El tratamiento inicial fue la exéresis con margen oncológico de la lesión en forma de coliflor y la electrofulguración, curetaje del resto de la lesi (more) ón y tratamiento antimicótico. En un período de 5 meses el enfermo presenta evolución tórpida con toma del estado general y elefantiasis del miembro superior izquierdo hasta región supraclavicular que obliga a realizarle amputación interescapulotorácica por la técnica de Berger para mejorar la calidad de vida. El diagnóstico histopatológico de los paquetes ganglionares resecados mostró metástasis de un carcinoma epidermoide. Abstract in english The case of a 74-year-old white male patient with a hyperpigmented and verrucose dermatological injury of more than 25 years of evolution in his left elbow and forearm is reported. He also has another cauliflower-like skin injury of recent evolution. Both presented histopathological diagnosis of chromomycosis. The initial treatment was exeresis with oncological margin of the cauliflower-like injury and electrofulguration, curettage of the rest of the injury and antimycoti (more) c treatment. In 5 months, the patient had a torpid evolution with taking of the general state and elephantiasis of the upper left extremity to the supraclavicular region that led to the interscapulothoracic amputation by Berger’s technique to improve his quality of life. The histopathological diagnosis of the resected ganglionar packages showed metastasis of an epidermoid carcinoma.

Collazo Álvarez, Hiralio; González Velázquez, Eridán; Pardillo Morales, Andrés G; Collazo Marín, Stephen Yecc

2001-12-01

254

Surgery and chemo radiation in stage 3A non-small cell lung cancer; Chirurgie et chimioradiotherapie dans les carcinomes bronchiques de stade  

Energy Technology Data Exchange (ETDEWEB)

Combination of surgery and radiotherapy has become a standard regimen in multiple cancers. Because of its toxicity and the higher metastatic potential of lung cancer, leading to underestimate the impact of loco-regional treatments, this strategy is currently used only in a clinical trial setting. Recent results from phase III studies comparing surgery and radiotherapy in stage IIIA-N2 locally advanced non-small cell lung cancer after induction treatment showed that surgery should only be performed in patients presenting with a major mediastinal down-staging and possible curative resection within a lobectomy. In all other cases, exclusive chemo-radiation remains the therapeutic standard at the time. In this way, all patients with stage III non-small cell lung cancer may receive induction treatment, consisting either in chemotherapy or in sequential or concurrent chemo-radiation, which has shown its feasibility and its efficacy regarding tumor response, resectability and local control rates. These two induction regimens are currently compared in randomized trials including stage III resectable and unresectable tumors at time of diagnosis. These developments make treatment of locally advanced non-small cell lung cancer a model for multimodal strategies in oncology, combining chemotherapy, radiotherapy and surgery. (author)

Hennequin, C. [Hopital Saint-Louis, Service de Cancerologie-Radiotherapie, 75 - Paris (France); Girard, N.; Mornex, F. [Hopital Lyon-Sud, Service de Radiotherapie-Oncologie, 69 - Lyon (France)

2006-11-15

255

Post irradiation eardrum: a rare complication of the radiotherapy of naso-pharynx carcinomas; Necrose tympanique postradique: une complication rare de la radiotherapie des carcinomes nasopharynges  

Energy Technology Data Exchange (ETDEWEB)

The eardrum necrosis is a serious and dreadful complication but rarely described after irradiation of cavum cancers. We report in this work five cases of eardrum necrosis after radiotherapy of nasopharynx carcinomas. Patients and methods: between february 1993 and december 2004 239 patients suffering of anon metastatic nasopharynx cancer have been treated by classical irradiation associated or not to a chemotherapy. The radiotherapy was delivered at the dose of 70 to 75 Gy in the cavum and the ganglions initially reached according a classical modality of hyperfractionated one. We analysed retrospectively the delayed complications occurred six months or more after the radiotherapy beginning. Results: Five cases of eardrum necrosis were reported sixty five months after the end of radiotherapy. these patients suffered of hypoacusia and buzzing. The clinical examination allowed to bring out the eardrum perforation that did not exist before radiotherapy. The total dose of irradiation was 75 Gy for a patient and 71.5 Gy according a hyperfractionated modality for four patients. Three patients had an hearing prosthesis in order to improve their quality of life. Conclusion: the eardrum necrosis after radiotherapy for nasopharynx cancer is a rare and unusual complication, very few reported in the literature. The total dose of irradiation is considered as the principal factor of occurrence risk in such complication. (N.C.)

Siala, W.; Mnejja, W.; Daoud, J. [CHU Habib-Bourguiba, Service de Radiotherapie Oncologique, Sfax (Tunisia); Khabir, A. [CHU Habib-Bourguiba, Service d' Anatomopathologie, Sfax (Tunisia); Ghorbel, A. [CHU Habib-Bourguiba, Service d' ORL, Sfax (Tunisia); Frikha, M. [CHU Habib-Bourguiba, Service d' Oncologie Medicale, Sfax (Tunisia)

2009-10-15

256

Contribution of radiotherapy in the treatment of cavum carcinomas at Yaounde; Apport de la radiotherapie dans le traitement des carcinomes du cavum a Yaounde  

Energy Technology Data Exchange (ETDEWEB)

A lot of works show that cavum carcinomas make of Cameroon an area at intermediary risks non negligible. The radiotherapy seems to be the only efficient technique but it is still non well known in our hospitals. This works wants to plaid in favor of its acknowledge and its optimal use by showing its contribution and its application difficulties. 5 refs., 1 tab.

Yomi, J.; Fouda, A.; Maloum, E.; Bengono, G.

1995-12-31

257

Salivary duct carcinoma: report of two cases and literature review; Carcinome canalaire de la glande parotide. A propos de deux cas et analyse de la litterature  

Energy Technology Data Exchange (ETDEWEB)

Salivary duct carcinomas are scarce tumour developed mainly in the male in the 6. or 7. decades of their life. Authors report two new cases developed 43 and 60 years-old in females. Because this tumour was localised, a radical treatment associating surgery and radiotherapy was performed. Follow-up were 115 and 137 months, and the two patients remain free of disease. These two cases were opportunity to discuss literature data. (author)

Benjelloun, H.; Maazouzi, A.; Benchakroun, N.; Acharki, A.; Tawfiq, N.; Saharoui, S.; Benider, A. [Centre Hospitalier Universitaire Ibn-Rochd, Centre d' Oncologie-Radiotherapie, Casablanca (Morocco)

2004-12-01

258

Retrospective analysis of 108 ductal carcinomas in situ of the breast treated by radiosurgery association; Analyse retrospective de 108 carcinomes canalaires in situ mammaires traites par association radiochirurgicale  

Energy Technology Data Exchange (ETDEWEB)

Purpose. - To evaluate survival and prognostic factors of 108 patients with clinically or mammo-graphically detected ductal carcinoma in situ (DCIS), treated from 1980 to 1996 by complete local excision followed by external irradiation. Patients and methods. - The median age was 51 (range 37-80). All the patients underwent surgery consisting of a wide resection of the mammary gland harboring the tumour. The surgical specimens were sent to the pathologists to get information on histology and margin clearance; all the slides were reviewed by one of us to assess the tumoral diameter. External beam therapy was delivered within 8 weeks after surgery. The prescribed irradiation dose was 50 Gy in 25 fractions to be given in 5 weeks. The median duration of follow-up was 93 months (range 40-173). Results. - There were nine patients with local recurrence (8.3%); three patients had local recurrence of DCIS and six patients developed invasive breast cancer. The treatment of local recurrence consisted of mastectomy with or without axillary dissection (eight cases) and quadrant-ectomy (one case). The 5-year and 10-year ipsilateral recurrence-free rate was respectively 92 and 89%. The 10-year cause specific survival was 100%. In univariate analysis, size {>=} 10 mm, age < 45 years old and margin status were significant P = 0,02. P 0,03, P = 0,005; margin status was significant in multivariate analysis (P < 0,02). Conclusion. - These results are in keeping with those of the literature. They could be improved by the mass screening campaign, which is going on since January 1990 among women aged 50 - 74 years. (authors)

Fourneret, P.; Artignan, X.; Cornulier, J. de; Kolodie, H.; Vincent, F.; Colona, M.; Bolla, M. [CHU de Grenoble, Service de cancerologie-radiotherapie, 38 - Grenoble (France); Pasquier, D. [CHU de Grenoble, Service d' anatomopathologie, 38 - Grenoble (France); Bernard, P. [CHU de Grenoble, Service de gynecologie, 38 - Grenoble (France); Payan, R. [Clinique Belledone, 38 - Saint-Martin-D' Heres (France); Frice, D. [Clinique du Mail, 38 - Grenoble (France); Colona, M.; Bolla, M. [Office Dept. de lutte contre le cancer, 38 - Meylan (France); Panh, M.H. [Registre du cancer de l' Isere, 38 - Meylan (France)

2006-12-15

259

Ductal in situ carcinoma: is it ethical to consider the breast conserving?; Carcinome canalaire in situ: est-il ethique de considerer le traitement conservateur comme un standard?  

Energy Technology Data Exchange (ETDEWEB)

The increasing incidence of DCIS during the past 20 years needs a continuous evaluation of the treatment strategies and a multidisciplinary decision process. The management of the DCIS remains a challenging issue in 2003. Mastectomy should still be considered as the reference treatment which is able to guarantee cure in almost all cases, whereas breast conserving surgery followed by radiation therapy is associated with 7-10% of local recurrence. However, the increasing knowledge of the predictive factors of the local recurrence allows to propose a conservative treatment strategy to a large amount of patients, without negative impact on their prognosis. This review presents the arguments that permit to justify, the reasoned choice of the different therapeutic options according to the clinico-pathological situations. (author)

Barillot, I. [Centre de Lutte Contre le Cancer Georges-Francois-Leclerc, Dept. de Radiotherapie, 21 - Dijon (France); Cutuli, B. [Polyclinique de Courlancy, Service de Radiotherapie-Cancerologie, 51 - Reims (France); Arnould, L. [Centre de Lutte Contre le Cancer Georges-Francois-Leclerc, Service d' Anatomie Pathologique, 21 - Dijon (France)

2004-02-01

260

Nasopharynx carcinomas. about 1342 cases treated at Oran, Algeria; Carcinomes du nasopharynx. A propos de 1342 cas traites a Oran, Algerie  

Energy Technology Data Exchange (ETDEWEB)

The purpose was to describe the epidemiology, clinical and therapy characteristics of the cavum cancer and the different post therapy results. The cavum cancer is frequent in west Algeria. It is the first cancer of superior aero digestive tracts, the fifth one fro man and the seventh for woman. It represents 8% of the whole of cancers treated at the radiotherapy service in Oran. It is chemosensitive and can be cured by radiotherapy but the frequency of locoregional recurrences and metastases remains high, despite all therapeutic methods used. (N.C.)

Khaldi, H.; Aid, M.; Lahmer, K.; Dali-Youcef, A.F. [Radiotherapie, Oran (Algeria)

2009-10-15

 
 
 
 
261

Trans-arterial chemo-embolization and conformal radiotherapy for hepatocellular carcinoma; Chimioembolisation et radiotherapie de conformation dans le traitement du carcinome hepatocellulaire  

Energy Technology Data Exchange (ETDEWEB)

Hepatocellular carcinoma is a poor prognosis tumour. The potential curative therapeutic options are ortho-topic liver transplantation, surgical resection and radiofrequency ablation. Unfortunately, only a minority of patients (around 20%) are eligible for these techniques. Thus, patients can benefit from palliative options, such as trans-arterial chemo-embolization (TACE) or sorafenib that bring only modest benefit on survival. Conformal radiotherapy allows delivering high dose radiation within a precise tumour volume while sparing the surrounding liver parenchyma. As employed in mono-therapy, conformal radiotherapy is highly efficient for small size hepatocellular carcinoma (< 5 cm). Above 5 cm, its efficacy is more limited but its association with TACE gives spectacular rates of complete responses. Controlled phase 2 or 3 trials are urgently warranted to define its indications in the therapeutic algorithm of hepatocellular carcinoma. (authors)

Merle, P. [Service d' hepatogastroenterologie, hopital de l' Hotel-dieu, 1, place de l' Hopital, 69002 Lyon (France); Inserm U871, equipe ' Oncogenese hepatique et hepatites virales' , 151, cours Albert-Thomas, 69003 Lyon (France); Universite Claude-Bernard Lyon 1, IFR62 Lyon-Est, 8, avenue Rockefeller, 69008 Lyon (France); Mornex, F. [Departement de radiotherapie-oncologie, centre hospitalier Lyon-Sud, chemin du Grand-Revoyet, 69310 Pierre-Benite (France); equipe ' Ciblage therapeutique par les agents physiques' , EA 37-38, universite Claude-Bernard Lyon 1, 43, boulevard du 11-Novembre-1918, 69622 Villeurbanne cedex (France)

2011-02-15

262

Non at small cells bronchi carcinomas. Analysis of the survival according to the treatment; Carcinome bronchique non a petites cellules. Analyse de la survie selon le traitement  

Energy Technology Data Exchange (ETDEWEB)

Most of the patients reached by lungs cancer are not operable at the time of diagnosis. The radio chemotherapy has not been superior to the radical radiotherapy. The bad results could be explained by the following causes: provinces population that consults too late, delays in the treatment start-up, inadequate support during the treatment for lack of economic means. The results of oncological treatments turned out to be superior to the symptomatic treatments. (N.C.)

Aguiar, S.; Dalla Rosa, M.; Luongo, A. [Faculte de Medecine, Hopital des Cliniques, Service d' Oncologie Radiotherapeutique, Montevideo (Uruguay); Barrios, E. [Faculte de Medecine, Hopital des Cliniques, Service d' Oncologie Medicale, Montevideo (Uruguay); Buccino, A.; Rodriguez, R. [Faculte de Medecine, Hopital des Cliniques, Dept. de Biophysique, Montevideo (Uruguay)

2001-06-01

263

Choanal stenosis: a rare complication of radiotherapy for nasopharyngeal carcinoma; Stenose choanale post-radique: une complication rare de la radiotherapie des carcinomes nasopharynges  

Energy Technology Data Exchange (ETDEWEB)

Choanal stenosis is usually a congenital anomaly in children. Acquired choanal stenosis after radiotherapy for nasopharyngeal carcinoma is a very rare pathology; only two publications report seven cases in the literature. We describe the clinical history, preoperative evaluation, surgical treatment and outcome of a case of acquired choanal stenosis after radiotherapy. The patient, a 56-year-old woman, presented with a history of nasopharyngeal carcinoma (T2- NO-MO) one year before that had been successful treated with radiotherapy (68 Gy). At the end of radiotherapy, she complained of complete nasal obstruction, anosmia and hearing loss due to a bilateral serous otitis media. Bilateral complete choanal stenosis was confirmed by endoscopy and CT scan. Functional endoscopic surgery was performed, and nasal stents were left in place for 3 weeks. One year after, the patient have good airflow, and a patent nasopharynx without choanal stenosis. In conclusion, choanal stenosis is an unusual complication of radiotherapy that can be successfully treated with trans-nasal endoscopic resection. (authors)

Bonfils, P.; Preobrajenski, N. de [Universite Rene-Descartes, Hopital Europeen Georges-Pompidou, Service d' ORL et de Chirurgie Cervicofaciale, Faculte de Medecine Paris-Descartes, 75 - Paris (France); Florent, A. [Cabinet d' ORL, 75 - Paris (France); Bensimon, J.L. [Cabinet de radiologie, 75 - Paris (France)

2007-05-15

264

Basaloid squamous carcinoma of the anal canal with an adenoid cystic pattern: histologic and immunohistochemical reappraisal of an unusual variant.  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Two cases of a distinctive variety of basaloid squamous carcinoma (BSC) of the anal canal are described. Both occurred in female patients who presented with bleeding per rectum. Histologic evaluation of the tumors showed lobules and aggregates of medium-sized basaloid cells with distinctive peripher...

Chetty, R; Serra, S; Hsieh, E

265

Systemic Amyloidosis Complicating Dermatoses.  

Science.gov (United States)

Certain dermatoses may be complicated by systemic amyloidosis. The underlying disorders in eight of 100 patients with secondary systemic amyloidosis studied at autopsy were: hidradenitis suppurativa, stasis ulcers, psoriatic arthritis, basal cell carcinom...

M. H. Brownstein E. B. Helwig

1970-01-01

266

Combined chemo-radiation for locally advanced non-small cell lung cancer: preliminary results; Essai d`association radio-chimiotherapique des carcinomes bronchiques non a petites cellules: resultats preliminaires  

Energy Technology Data Exchange (ETDEWEB)

Analysis of the preliminary results of a phase I study investigating the feasibility of concomitant chemotherapy with daily doses of carboplatin (20 to 25 mg/m{sup 2}/d over 45 or 10 min) and accelerated chest irradiation (60 to 64 Gy over 4 weeks, 2 Gy per fraction, using the concomitant boost technique). Materials and methods: This combination was given alone or following three cycles of induction chemotherapy (cisplatin, 25 mg/m{sup 2} per day from d1 to d5; 5-fluorouracil, 600 mg/m{sup 2} per day from d1 to d5 and vinorelbine, 25 mg/m{sup 2} per day at d1 and d5 with a 4-week interval) in 15 patients with locally advanced unresectable non-small cell lung cancer. All patients received the planned sequence. Results: The dose-limiting toxicity was oesophagitis (5 out of 15 grade 4). No toxic deaths were observed. The tumor response rate was high: six out of 15 complete responses and 14 out of 15 tumor regressions greater than 50%. The median survival was not reached after a mean follow-up of 14 months (range, 6-28 months). Conclusion: We are now planning a multicenter phase II study carboplatin over 10 min and a 60-Gy irradiation dose over 4 weeks. (authors). 14 refs.

Livartowski, A.; Dierick, A.; Beuzeboc, P.; Pouillart, P.; Dubray, B.; Cosset, J.M. [Institut Curie, 75 - Paris (France)

1997-09-01

267

Results of conservative treatment with surgery and radiation therapy of 132 non-palpable ductal carcinomas in situ of the breast; Resultats du traitement par chirurgie conservatrice et irradiation de 132 carcinomes canalaires in situ non palpables du sein  

Energy Technology Data Exchange (ETDEWEB)

Retrospective analysis of results of treatment of 132 subclinical ductal carcinomas in situ, non-palpable. Patients were treated with limited surgery and 70 Gy radiation therapy (70 Gy). With a median follow-up of 7 years, the total recurrence rate was 6 % and the actuarial rate at 5 years 4 % and at 10 years 13 % at. These have no influence on recurrence on the specific actuarial survival rate which was 100 % at 10 years. In spite of five infiltrating recurrences of seven, no metastasis appeared 48 months after the salvage surgery. The global rate of breast. The global rate of breast preservation was 92 % at 7 years. Therapeutic indications were developed taking into account the present analysis and a literature review (2,338 in situ ductal carcinomas, palpable or not, treated with conservative surgery, with or without adjuvant radio-therapy). (author)

Amalric, R.; Brandone, H.; Dubau, A.; Hans, D.; Brandone, J.M.; Robert, F.; Pollet, J.F.; Amalric, F.; Rouah, Y.; Thomassin, L.; Giraud, D.; Henric, A.; Martin, P.M.; Romain, S. [Academie mediterraneenne d`oncologie clinique, Polyclinique Clairval, 13 - Marseille (France)

1998-01-01

268

Radio-induced glioblastoma and myxoma after treatment of undifferentiated carcinoma of the nasopharynx; Glioblastome et myxome radio-induits apres traitement d'un carcinome indiffencie du nasopharynx  

Energy Technology Data Exchange (ETDEWEB)

Radio-induced tumor have been known for a long time to occur after treatment of cancer during childhood. This entity is exceptional following radiotherapy of the cavum. Skull and facial osteosarcoma were described after treatment of UCNT. We report two observations of radio-induced tumors arising respectively three and seven years after treatment of UCNT. The first one is a temporo-parietal glioblastoma and the second is a rhino- and pharyngeal myxoma. The two patients are alive after treatment of the second tumor. The delay of appearance of these tumors, their situation in the field's irradiated and dose received suggests their radioinduced nature. However, the cytogenetic study is necessary to confirm the implication of radiotherapy in the genesis of these cancers. (authors)

Daoud, J.; Ben Salah, H. [Centre Hospitalier Universitaire Habib-Bourguiba, Service de Carcinologie-Radiotherapie, Sfax (Tunisia); Kammoun, W.; Ghorbel, A.; Drira, M.M. [Centre Hospitalier Universitaire Habib-Bourguiba, Service ORL, Sfax (Tunisia); Frikha, M. [Centre Hospitalier Universitaire Habib-Bourguiba, Service de Carcinologie Medicale, Sfax (Tunisia); Jlidi, R. [Centre Hospitalier Universitaire Habib-Bourguiba, Lab. d' Anatomo-Pathologie, Sfax (Tunisia); Besbes, M.; Maalej, M. [Institut Salah-Azaiz, Service de Carcinologie-Radiotherapie, Tunis (Tunisia)

2000-12-01

269

What extension evaluation before therapy have we to do in the nasopharynx cancers?; Quel bilan d'extension pretherapeutique faut-il faire dans les carcinomes du nasopharynx?  

Energy Technology Data Exchange (ETDEWEB)

NMR imaging has proved its superiority on scanography in the study of limits and tumor extension and should be the first examination. The practice of of a scanography or cervical NMR should be the best mean of ganglions evaluation. As regards the extension evaluation at distance, it is recommended to require systematically a thorax radiograph and a bone scintigraphy for any patient. The liver echography is rather indicated among male patients, aged between 40 and 45 and having a stage 3 lymph node (according to the U.I.C.C. 1997 classification). (N.C.)

Elloumi, F.; Mnejja, W.; Siala, W.; Daoud, J. [Centre Hospitallie Universitaire Habib-Bourguiba, Service de Radiotherapie Carcinologique, Sfax (Tunisia); Hammami, B.; Ghorbel, M. [Centre Hospitallie Universitaire Habib-Bourguiba, Service ORL, Sfax (Tunisia); Frikhan, M. [Centre Hospitallie Universitaire Habib-Bourguiba, Service de Carcinologie Medicale, Sfax (Tunisia)

2007-11-15

270

Significado clínico-patológico das expressões citofotométricas do Ki-67 e Caspase-3 no carcinoma de células escamosas do esôfago/ Clinicopathologic significance of the Ki-67 and Caspase-3 cytophotometric expressions in the esophageal squamous cell carcinomal  

Scientific Electronic Library Online (English)

Full Text Available Abstract in portuguese RACIONAL: A escolha da forma de tratamento do carcinoma de células escamosa de esôfago ainda hoje é orientada pelo estadiamento tumoral, onde as características histopatológicas do tumor são o maior determinante. Parale-lamente, desenvolvem-se estudos para entender o comportamento da biologia tumoral por método imunoistoquímico de quantificação manual, avaliando a ati-vidade proliferativa ou apoptótica do tecido em análise. As desvantagens conti-das no modo ma (more) nual fizeram surgir e desenvolver método computadorizado de análise de imagem. OBJETIVOS: Verificar as expressões dos marcadores KI-67 e Caspase-3 e correlacioná-las com as características clínico-patológicas do tumor. MÉTODOS: Foram estudados 29 blocos parafinados provenientes de pa-cientes portadores de carcinoma de células escamosas de esôfago submetidos à esofagectomia e pertencentes a acervos de laboratórios de patologia. Proce-deu-se preparo das lâminas por técnica imunoistoquímica convencional. A quantificação da imunorreatividade às proteínas Ki-67 e Caspase-3 foi realizada pelo software de análise de imagem computadorizada SAMBA (Systeme d'Analyse Microphotometrique a Balayage Automatique) através do índice de marcagem encontrado. RESULTADOS: Predominaram na amostra o sexo mascu-lino (82,7%); maiores de 50 anos; tumores moderadamente diferenciados (68,98%); estágio III (72,42%); lesões >3cm e localizadas no ? inferior do ór-gão. Os índices médios de marcagem identificados foram de 62,05% para o Ki-67 e 86,06% para a Caspase-3, e não mostraram correlação com as caracterís-ticas clínico-patológicas como sexo, idade, estadiamento tumoral, grau de pro-fundidade da lesão e comprometimento linfonodal. Houve significante diferença de expressão do Ki-67 entre os graus histológicos (P=0,047) e correlação entre os índices dos marcadores estudados (r=0,41 e P =0,032). CONCLUSÃO: Na presente investigação as atividades das proteínas estudadas se mostraram in-tensas sendo que a da Caspase-3 foi superior ao Ki-67 mas sem correlação com as características clínico-patológicas. Abstract in english BACKGROUND: The esophageal squamous cell carcinoma treatment strategy is still based on the tumor staging, where tumor histopathologic charac-teristics are the major determinants. In parallel, studies have been developed in order to better understand the tumor biology using immunohistochemical meth-ods with manual quantification evaluating the proliferative and apoptotic activi-ties of the cells. The disadvantages related to the manual method rose the de-velopment of comp (more) uterized ways to do the image analysis. OBJETIVES: To verify the expressions of the markers Ki-67 (proliferative) and Caspase-3 (apoptotic) and to correlate them with the clinic and pathologic characteristics of the tumor. METHODS: Twenty-nine paraffin embedded blocks were studied, each one con-taining tissue samples from patients with esophageal squamous cell carcinoma submitted to esophagectomies. The clinic and pathological data were obtained from histopathologic informations and from medical records. The slides were prepared following the routine immunohistochemical method until the point to utilize the specific antibodies (MIB-1 and CPP32). Positive quantification of the immunoreactivity to the proteins Ki-67 and Caspase-3 was performed by the software for computerized image analysis SAMBA (Systeme d' Analyse Micro-photometrique a Balayage Automatique). Statistical analysis was done having P

Silva, Gilmar Pereira; Malafaia, Osvaldo; Cuenca, Ronaldo Máfia; Ribas-Filho, Jurandir Marcondes; Nassif, Paulo Afonso Nunes; Ribas, Carmen Australia Paredes Marcondes; Zeve, Jorge Luiz de Matos

2008-06-01

271

Significado clínico-patológico das expressões citofotométricas do Ki-67 e Caspase-3 no carcinoma de células escamosas do esôfago Clinicopathologic significance of the Ki-67 and Caspase-3 cytophotometric expressions in the esophageal squamous cell carcinomal  

Directory of Open Access Journals (Sweden)

Full Text Available RACIONAL: A escolha da forma de tratamento do carcinoma de células escamosa de esôfago ainda hoje é orientada pelo estadiamento tumoral, onde as características histopatológicas do tumor são o maior determinante. Parale-lamente, desenvolvem-se estudos para entender o comportamento da biologia tumoral por método imunoistoquímico de quantificação manual, avaliando a ati-vidade proliferativa ou apoptótica do tecido em análise. As desvantagens conti-das no modo manual fizeram surgir e desenvolver método computadorizado de análise de imagem. OBJETIVOS: Verificar as expressões dos marcadores KI-67 e Caspase-3 e correlacioná-las com as características clínico-patológicas do tumor. MÉTODOS: Foram estudados 29 blocos parafinados provenientes de pa-cientes portadores de carcinoma de células escamosas de esôfago submetidos à esofagectomia e pertencentes a acervos de laboratórios de patologia. Proce-deu-se preparo das lâminas por técnica imunoistoquímica convencional. A quantificação da imunorreatividade às proteínas Ki-67 e Caspase-3 foi realizada pelo software de análise de imagem computadorizada SAMBA (Systeme d'Analyse Microphotometrique a Balayage Automatique) através do índice de marcagem encontrado. RESULTADOS: Predominaram na amostra o sexo mascu-lino (82,7%); maiores de 50 anos; tumores moderadamente diferenciados (68,98%); estágio III (72,42%); lesões >3cm e localizadas no ? inferior do ór-gão. Os índices médios de marcagem identificados foram de 62,05% para o Ki-67 e 86,06% para a Caspase-3, e não mostraram correlação com as caracterís-ticas clínico-patológicas como sexo, idade, estadiamento tumoral, grau de pro-fundidade da lesão e comprometimento linfonodal. Houve significante diferença de expressão do Ki-67 entre os graus histológicos (P=0,047) e correlação entre os índices dos marcadores estudados (r=0,41 e P =0,032). CONCLUSÃO: Na presente investigação as atividades das proteínas estudadas se mostraram in-tensas sendo que a da Caspase-3 foi superior ao Ki-67 mas sem correlação com as características clínico-patológicas.BACKGROUND: The esophageal squamous cell carcinoma treatment strategy is still based on the tumor staging, where tumor histopathologic charac-teristics are the major determinants. In parallel, studies have been developed in order to better understand the tumor biology using immunohistochemical meth-ods with manual quantification evaluating the proliferative and apoptotic activi-ties of the cells. The disadvantages related to the manual method rose the de-velopment of computerized ways to do the image analysis. OBJETIVES: To verify the expressions of the markers Ki-67 (proliferative) and Caspase-3 (apoptotic) and to correlate them with the clinic and pathologic characteristics of the tumor. METHODS: Twenty-nine paraffin embedded blocks were studied, each one con-taining tissue samples from patients with esophageal squamous cell carcinoma submitted to esophagectomies. The clinic and pathological data were obtained from histopathologic informations and from medical records. The slides were prepared following the routine immunohistochemical method until the point to utilize the specific antibodies (MIB-1 and CPP32). Positive quantification of the immunoreactivity to the proteins Ki-67 and Caspase-3 was performed by the software for computerized image analysis SAMBA (Systeme d' Analyse Micro-photometrique a Balayage Automatique). Statistical analysis was done having P3cm; and lesions located in the lower third of the organ. The mean score indexes found were 62.05% for Ki-67 and 86.06% for Caspase-3 and there was no correlation with the clinic or pathologi-cal characteristics as gender, age and tumor staging. There was significant dif-ference of Ki-67 expression among the histological grades (P=0.047) and corre-lation between the evaluated indexes (r=0.41 and P=0.032). CONCLUSION: The protein expressions were high and the Caspase-3 protein activity was higher than the Ki-67, without correlation with clinic or pathological

Gilmar Pereira Silva; Osvaldo Malafaia; Ronaldo Máfia Cuenca; Jurandir Marcondes Ribas-Filho; Paulo Afonso Nunes Nassif; Carmen Australia Paredes Marcondes Ribas; Jorge Luiz de Matos Zeve

2008-01-01

272

Interest of the SPECT-CT hybrid imaging in the management of thyroid differentiated carcinomas; Interets de l'imagerie hybride TEMP-TDM dans la prise en charge des carcinomes differencies de la thyroide  

Energy Technology Data Exchange (ETDEWEB)

Purpose: Images merging, associating SPECT and CT, integers functional and anatomical data. The purpose of our study was to evaluate the SPECT contribution coupled to CT in our daily practice of the management thyroid differentiated carcinomas. Conclusions: SPECT/CT merging got by a hybrid system allows a better anatomical location and improves the diagnostic value of examination in the extension assessment of thyroid differentiated carcinomas. (N.C.)

Menemani, A.; Mebarki, M.; Slama, A.; Meghelli, S.; Lachachi, B.; Krim, M.; Berber, N. [CHU Tlemcen, Service de medecine nucleaire (Algeria)

2010-07-01

273

Clear cell carcinoma of the larynx: one case report and review of the literature; Carcinome a cellules claires du larynx: revue de la litterature, a propos d'un cas  

Energy Technology Data Exchange (ETDEWEB)

Clear cell carcinoma of the larynx is exceptional. Only six cases are described in the literature. We report a new case occurring in a 58-year-old man. The treatment consisted of a total laryngectomy with lymph node dissection followed by adjuvant irradiation. Local and regional recurrence occurred after 5 months. The patient died from the tumor's evolution 12 months after the diagnosis. The prognosis of clear cell carcinoma of the larynx is similar to the clear cell carcinoma of the lung and is unfavorable. (authors)

Sahraoui, S.; Acharki, A.; Kahlain, A.; Belaabidia, B.; Sqali, S. [Centre Hospitalier Universitaire Ibn Rochd, Casablanca (Morocco)

2001-04-01

274

Secondary mandibular fibrosarcoma after chemoradiotherapy for undifferentiated nasopharyngeal carcinoma. Report of a case and literature review; Fibrosarcome secondaire de la mandibule apres chimioradiotherapie pour carcinome indifferencie du nasopharynx. A propos d'une observation et revue de la litterature  

Energy Technology Data Exchange (ETDEWEB)

Secondary mandibular fibrosarcoma after chemoradiotherapy for undifferentiated nasopharyngeal carcinoma. Report of a case and literature review. Secondary tumours to radio- and/or chemotherapy have rarely been reported after treatment for head and neck cancers. We report a case of mandibular fibrosarcoma observed 7 years after chemoradiotherapy for undifferentiated nasopharyngeal carcinoma in a patient treated when 20 years old. (authors)

Kochbati, L.; Besbes, M.; Benna, F.; Maalej, M. [Institut Salah Azaiz, Service de Radiotherapie, Tunis (Tunisia); Boussen, H.; Ben Ayed, F. [Institut Salah Azaiz, Service de Medecine, Tunis (Tunisia); Gritli, S.; Ladgham, A. [Institut Salah Azaiz, Service de Chirurgie ORL, Tunis (Tunisia); Saadi, A. [Institut Salah Azaiz, Service de Radiodiagnostic, Tunis (Tunisia); El May, A. [Institut Salah Azaiz, Service d' Anatomopathologie, Tunis (Tunisia)

2001-06-01

275

Oesophageal squamous cell carcinoma Stade 3. State of surgery after radio chemotherapy (R.C.T.); Carcinomes malpighiens de l'oesophage de stade 3, place de la chirurgie apres chimioradiotherapie  

Energy Technology Data Exchange (ETDEWEB)

Neo-adjuvant chemoradiotherapy is the gold standard of the treatment of advanced oesophageal squamous cell carcinoma. The role of surgery L. chemoradiotherapy is still debated. Feasibility of curative resection depends on dose of radiotherapy, morbi-mortality rates, and nutrition status at the end of the protocol especially for non-responders patients. Adding surgery to radio-chemotherapy improves local tumour control but does not increase overall survival of patients with advanced oesophageal squamous cell carcinoma. According to the two randomized trials published on the subject, surgery is not recommended after chemoradiotherapy for responders. Recommendations of French National Thesaurus are: exclusive chemoradiotherapy as reference, oesophagectomy for residual tumour as alternative for operable patients. Surgery may be proposed for selected non-responders patients and some complete pathology response in expert center. (author)

Triboulet, J.P.; Mariette, C. [Hopital Claude-Huriez, Service de Chirurgie Digestive et Generale, 59 - Lille (France)

2006-11-15

276

Prospective study of accelerated postoperative radiation therapy in patients with squamous-cell carcinoma of the head and neck; Radiotherapie externe acceleree postoperatoire des carcinomes epidermoides localement evolues de la sphere ORL: etude prospective de phase 2  

Energy Technology Data Exchange (ETDEWEB)

Purpose. - To assess the feasibility and efficacy of accelerated postoperative radiation therapy (RT) in patients with squamous-cell carcinoma of the head and neck (SCCHN). Patients and methods. - Between December 1997 and July 2001, 68 patients (male to female ratio: 52/16; median age: 60-years (range: 43-81)) with pT1-pT4 and/or pN0-pN3 SCCHN (24 oropharynx, 19 oral cavity, 13 hypopharynx, 5 larynx, 3 unknown primary, 2 maxillary sinus, and 2 salivary gland) were included in this prospective study. Postoperative RT was indicated because extra-capsular infiltration (ECT) was observed in 20 (29%), positive surgical margins (PSM) in 20 (29%) or both in 23 patients (34%). Treatment consisted of external beam R 66 Gy in 5 weeks and 3 days. Median follow-up was 15 months. Results. -According to CTC 2.0, acute morbidity was acceptable: grade 3 mucositis was observed in 15 (22%) patients, grade 3 dysphagia in 19 (28%) patients, grade 3 skin erythema in 21 (31%) patients with a median weight loss of 3.1 kg (range: 0-16). No grade 4 toxicity wa observed. Median time to relapse was 13 months; we observed only three (4%) local and four (6%) regional relapses, whereas eight (12%) patients developed distant metastases without any evidence of locoregional recurrence. The 2 years overall-, disease-free survival, an actuarial locoregional control rates were 85, 73 and 83% respectively. Conclusion.- The reduction of the overall treatment time using postoperative accelerated RT with weekly concomitant boost (six fraction per week) is feasible with local control rates comparable to that of published data. Acute RT related morbidity is acceptable. (author)

Zouhair, A.; Coucke, P.A.; Azria, D.; Moeckli, R.; Mirimanoff, R.O.; Ozsahin, M. [Centre Hospitalier Universitaire Vaudois CHUV, Service de Radio-Oncologie, Lausanne (Switzerland); Azria, D. [Centre Regional de Lutte Contre le Cancer Val-d' Aurelle-Paul-Lamarque, Dept. d' Oncologie- Radiotherapie, 34 - Montpellier (France); Pache, P. [Centre Hospitalier Universitaire Vaudois CHUV, Service d' ORL, Lausanne (Switzerland); Stupp, R. [Centre hospitalier Universitaire Vaudois CHUV, Centre Pluridisciplinaire d' Oncologie Medicale, Lausanne (Switzerland)

2003-08-01

277

Epidermoid carcinomas of the anal canal treated with definitive radiation therapy in a series of 305 patients; Carcinomes epidermoides du canal anal traites par irradiation a visee curative: a propos de 305 patients  

Energy Technology Data Exchange (ETDEWEB)

Purpose. - To identify prognostic factors and treatment toxicity in a series of epidermoid cancers of the anal canal without evident metastasis. Patients and methods. - Between June 1972 and January 1997, 305 patients (pts) were treated with curative-intent radiation therapy (RT). The T-stages according to the 1987 UICC classification were: 26 T1, 141 T2, 104 T3, and 34 T4. There were 49 pts with nodal involvement at presentation. Pretreatment anal function scoring according to our in-house system was: 22 scored 0, 182 scored 1, 74 scored 2, 7 scored 3. 11 scored 4, and 9 not available pts. The treatment started with external beam RT (EBRT) in 303 pts (median dose: 45 Gy). After a rest period of 4 to 6 weeks, a boost of 20 Gy was delivered by EBRT in 279 pts and by interstitial {sup 192}Ir brachytherapy (Bcy) in 17 pts. Seven pts received only one course of EBRT (mean dose: 49.5 Gy) and 2 pts were treated with interstitial {sup 192}Ir Bcy alone (55 and 60 Gy, respectively). concomitant chemotherapy (5-fluoro-uracil and either mitomycin C or cisplatin) was delivered to 19 pts. Mean follow-up was 103 months. Results. - At the end of RT local tumor clinical complete response (cCR) rate was 80%. Out of 61 non responders or local progressive tumors 27 (44%) were salvaged with abdomino-perineal resection (APR). The rate of local tumor relapse (LR) was 12%. Out of 37 LTR, 20 (54%) were salvaged with APR and one with interstitial {sup 192}Ir Bcy. The overall local tumor control (LC) rate with or without salvage local treatment was 84%. LC rate with a good anal function scoring (score 0 and 1) was 56.5%0. Among 181/186 available pts who preserved their anus, 94% had a good anal function scoring. For a subgroup of 15 pts with length tumor <2 cm-N0, the LC rate after the end of RT was 100% the LC rate with or without local salvage treatment was 100%, and among 13 available pts who preserved their anus, the anal function scoring was good in 12 pts (92%). The 10-years disease-free survival was 74%. After multivariate analysis, 3 independent predicting factors significantly influenced the disease-free survival: gap duration between 2 courses of RT (>38 days vs {<=}38 days, P=0.0025), pretreatment anal function scoring (0 vs 1 vs 2 vs 3 vs 4, P =4.4 10{sup -6}), and cCR after the end of RT (no complete response vs complete response, P =2.5 10{sup -14}). Conclusion. - We confirm excellent results with RT in T1 and T2 lesions. However, chemoradiotherapy should be preferred to improves survival free. of colostomy with a good anal sphincter function for tumors more than or equal to 2 cm in length and locally advanced tumors. (author)

Deniaud-Alexandre, E.; Touboul, E.; Huang, R.; Qu, S.H.; Pene, F.; Schlienger, M. [Hopital Tenon, Service d' Oncologie-Radiotherapie, 75 - Paris (France); Tiret, E.; Parc, R. [Hopital Saint-Antoine, Service de Chirurgie Digestive, 75 - Paris (France); Sezeur, A. [Hopital des Diaconesses, Service de Chirurgie Generale, 75 - Paris (France); Houry, S. [Hopital Tenon AP-HP, Service de Chirurgie Digestive, 75 - Paris (France); Gallot, D. [Groupe Hospitalier Bichat-Claude-Bernard, Service de Chirurgie Generale et Digestive B, 75 - Paris (France)

2003-08-01

278

The place of radiotherapy in muco-epidermoid carcinomas of salivary glands in child; Place de la radiotherapie dans les carcinomes mucoepidermoides des glandes salivaires de l'enfant  

Energy Technology Data Exchange (ETDEWEB)

As muco-epidermoid carcinomas are the most frequent tumours of salivary glands for child, the authors report the study of the role of radiotherapy. This study is based on a survey performed in 34 paediatric departments. The authors analyse the age and gender, the use of irradiation, the tumour location, the tumour grade and size, the use of surgery and of radiotherapy, and survival. Radiotherapy is beneficial for high grade tumours, but cannot be recommended for low and intermediate grades. Short communication

Thariat, J. [Centre Antoine-Lacassagne, Nice (France); Temam, S. [Institut Gustave-Roussy, Villejuif (France); Orbach, D. [Institut Curie, Paris (France); Nicollas, R.; Penicaud, M. [Hopital La Timone, Marseille (France); Toussaint, B. [CHU, Nancy (France); Makeieff, M. [CHU, Montpellier (France); Laprie, A. [Institut Claudius-Regaud, Toulouse (France); Castillo, L. [CHU, Nice (France); Vedrin, P. [CHC de Cannes, Cannes (France)

2011-10-15

279

Interest of the serous dosage of HER-2/neu, EGFr, VEGF, IL6 and Ac anti-P53 among patients damaged by an esophagus epidermoid carcinoma, type epidermoid carcinoma whom treatment was an exclusive chemoradiotherapy; Interet du dosage serique de HER-2/neu, EGFr, VEGF, IL6 et Ac anti-P53 chez des patients atteints d'un carcinome epidermoide de l'oesophage de type carcinome epidermoide dont le traitement etait une chimioradiotherapie exclusive  

Energy Technology Data Exchange (ETDEWEB)

The serous concentrations of EGFr and HER2/neu seem to have a potential interest in the framework of the assumption of esophagus epidermoid carcinomas. A next step consists in comparing the serous value of these markers with their tissue expression on biopsies. A prospective study in parallel of a therapeutic trial is starting up to validate these results on a bigger number of patients. (N.C.)

Metges, J.P.; Le Tallec-Jestin, V.; Mahlaire, J.P.; Pradier, O. [Departement de Cancerologie, 29 - Brest (France); Guenet, D.; Volant, A. [Service d' anatomopathologie, 29 - Brest (France); Codet, J.P. [Service de Medecine Nucleaire, 29 - Brest (France)

2006-11-15

280

[Anesthetic management with remifentanil during thoracic surgery in a pediatric patient--case report of a patient with congenital cyst adenoid malformation].  

UK PubMed Central (United Kingdom)

We gave general anesthesia for the lower right lobe resection in an infant with congenital cystic adenomatoid malformation (CCAM). Anesthesia was performed with sevoflurane inhalation, intravenous infusion of remifentanil and intermittent injection of fentanyl. Intraoperative anesthetic course was uneventful except for failure of one lung ventilation. After all surgical procedures, intercostal nerve block under direct vision by surgeon and intravenous infusion of fentanyl were performed for postoperative analgesia. Emergence from anesthesia was prompt, and the tracheal tube could be removed without any troubles. Remifentanil is an effective and safe opioid to use for thoracic surgery even in infants.

Nishi H; Tokeshi S; Iha H; Nakahara I; Kakinohana M; Sugahara K

2011-10-01

 
 
 
 
281

Oral Cancer Removal and Palate Reconstruction  

Medline Plus

Full Text Available ... Browne is going to remove an adenoid cystic carcinoma from the hard palate… [clears throat]…of a ... the defect. 00:06:37 Often, adenoid cystic carcinoma, the type of cancer that we’re working ...

282

Tonsillectomy and Adenoidectomy  

Medline Plus

Full Text Available ... the mouth. The tonsils are part of the immune system and help fight infections. Eustachian tube The adenoids ... mouth. The adenoids are also part of the immune system and help fight infections. The uvula is also ...

283

Sinus Tumors  

Science.gov (United States)

... include squamous cell carcinoma, adenocarcinoma, adenoid cystic carcinoma, mucoepidermoid carcinoma, melanoma, olfactory neuroblastoma (esthesioneuroblastoma), sarcoma, and lymphoma. Malignant ...

284

M?tastase pancr?atique m?tachrone du cancer du rein : ? propos d'un cas  

Science.gov (United States)

Résumé Les métastases pancréatiques du cancer du rein sont rares et surviennent le plus souvent plusieurs années après la néphrectomie. Le traitement chirurgical est souvent possible, permettant une bonne survie à distance. Nous rapportons le cas d’une métastase pancréatique métachrone d’un carcinome rénal à cellules claires 16 ans après la néphrectomie.

Mqirage, Mohammed; Egurrola, Jose Antonio Zabala; Rodriguez, Jorge Garcia-Olaverri; Pena, Carlos Pertusa

2013-01-01

285

?1 Integrin/FAK/cortactin signaling is essential for human head and neck cancer resistance to radiotherapy  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Integrin signaling critically contributes to the progression, growth, and therapy resistance of malignant tumors. Here, we show that targeting of ?1 integrins with inhibitory antibodies enhances the sensitivity to ionizing radiation and delays the growth of human head and neck squamous cell carcinom...

Eke, Iris; Deuse, Yvonne; Hehlgans, Stephanie; Gurtner, Kristin; Krause, Mechthild; Baumann, Michael; Shevchenko, Anna

286

Primary small cell carcinoma of the breast with TTF-1 and neuroendocrine marker expressing carcinoma in situ  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Primary small cell carcinoma (SmCC) of the breast is very rare and may be difficult to distinguish from me-tastatic small cell carcinoma. Confident histopathological diagnosis of a primary breast SmCC requires the demonstration of an in situ component. We report a case of primary small cell carcinom...

Christie, Michael; Chin-Lenn, Laura; Watts, Monique M; Tsui, Alpha E; Buchanan, Malcolm R

287

Allografts of tumor nuclear transplantation embryos: differentiation competence.  

Digital Repository Infrastructure Vision for European Research (DRIVER)

The developmental potential of nuclei can be studied by nuclear transplantation. Although amphibian blastula nuclei and other early embryonic nuclei are totipotent, to our knowledge no nucleus from an adult cell has ever been shown to be totipotent by this procedure. Transfer of Lucké renal carcinom...

Lust, J M; Carlson, D L; Kowles, R; Rollins-Smith, L; Williams, J W; McKinnell, R G

288

Rôle de SR-BI et CD81 dans l'entrée et l'échappement du virus de l'hépatite C  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Le virus de l'hépatite C (VHC) est l'une des causes majeures de cirrhose du foie et de carcinome hépatocellulaire. Au courant de la première partie de ma thèse, nous nous sommes intéressés à caractériser plus en détail le rôle de SR-BI dans l'infection par le VHC. Bien que les mécanismes impliquant ...

Zahid, Muhammad Nauman

289

Radio response of the lung after treatment of the mammary carcinoma with telecaesium - correlation with the dose-time relationship  

International Nuclear Information System (INIS)

51 mamma carcinom patients underwent postoperative telecaesium irradiation (50 Gy). Chest radiograms were taken preceding the treatment and following it by eight to ten weeks. By reason of the results it can be supposed, that the unavoidable lung reaction due to radiotherapy can be decreased and partly avoided by adequate fractionation. (orig.).

1990-01-01

290

Cutaneous sporotrichosis: Unusual clinical presentations  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Three unusual clinical forms of sporotrichosis described in this paper will be a primer for the clinicians for an early diagnosis and treatment, especially in its unusual presentations. Case 1, a 52-year-old man, developed sporotrichosis over pre-existing facial nodulo-ulcerative basal cell carcinom...

Mahajan Vikram; Sharma Nand; Shanker Vinay; Gupta Poonam; Mardi Kavita

291

Methanol extraction residue of BCG in the treatment of transplanted rat tumours.  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Subcutaneous growth of immunogenic chemically induced rat sarcomata and a hepatoma was restricted when cells were injected into syngeneic animals in admixture with MER. Rats rejecting mixed inocula were immune to further challenge with the same tumour. Growth of a chemically induced mammary carcinom...

Hopper, D. G.; Pimm, M. V.; Baldwin, R. W.

292

Priapism secondary to penile metastasis of rectal cancer  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Metastatic penile carcinoma is rare and usually originates from genitourinary tumors. The presenting symptoms or signs have been described as nonspecific except for priapism. Rectal adenocarcinoma is a very unusual source of metastatic penile carcinoma. We report a case of metastatic penile carcinom...

Park, Ji Chan; Lee, Wook Hyun; Kang, Min Kyu; Park, Suk Young

293

Fine-needle aspiration biopsy: pancreatic and biliary tumors.  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Fine-needle aspiration biopsy was performed in 240 patients with suspected pancreatic or biliary tumors between 1978 and 1984. Between 1978 and 1982, using only sonographic guidance, the sensitivity of the technique was 66.7% for pancreatic and 40% for biliary tumors compared with 79.4% for carcinom...

Hall-Craggs, MA; Lees, WR

294

Impact of {sup 18}F-fluoro-deoxy-glucose positron emission tomography (F.D.G.-PET) in recurrent colorectal cancer; Evaluation de la TEP au {sup 18}F-F.D.G. dans l'exploration de la recidive des carcinomes colorectaux  

Energy Technology Data Exchange (ETDEWEB)

Purpose The aim of the study was to evaluate the diagnostic performance, the prognosis factors and the therapeutic impact of {sup 18}F-F.D.G. positron emission tomography (F.D.G.-PET) in the detection of recurrent colorectal cancers. Methods Sixty PET/CT with {sup 18}F-F.D.G. and CT were performed in 52 patients, at the Paul Papin cancer center between 2003 and 2005, following suspicion of colorectal cancer relapse. The F.D.G.-PET impact on the clinical management was studied by examination of multidisciplinary consultations results. Survival analysis were realized with a mean follow up of 2.2 years. Results Recurrence was confirmed for 50 explorations by histologic (n = 32), radiologic (n = 14) or clinical (n = 4) findings. Twenty patients died during the time of the study. On a patient based analysis, F.D.G.-PET sensitivity, specificity and overall accuracy were 90, 90, 90% respectively compared with 74, 50 and 70% for CT. F.D.G.-PET changed the clinical management in 18 cases (30%). A positive F.D.G.-PET signal, more than one hepatic lesion, more than two lymph node lesions detected on F.D.G.-PET and more than two hepatic lesions on CT were characterized as bad prognostic factors for survival. Multivariate analysis showed that the only independent bad prognostic factor was the F.D.G.-PET detection of more than two liver lesions. Conclusion These results confirmed the important impact of F.D.G.-PET in the clinical management of patients with a suspected recurrence of colorectal cancer. (authors)

Metrard, G.; Morel, O.; Girault, S.; Soulie, P.; Guerin-Meyer, V.; Lorimier, G.; Gamelin, E. [Centre Paul-Papin, 49 - Angers (France); Metrard, G.; Jeanguillaume, C.; Berthelot, C.; Le Jeune, J.J. [Centre Hospitalier Universitaire, Service de Medecine Nucleaire, 49 - Angers (France); Parot-Schinkel, E. [Centre Hospitalier Universitaire, Service de Recherche Clinique, 49 - Angers (France)

2009-09-15

295

Impact of additional cervical dedicated {sup 18}FDG-PET-CT on the management of head and neck squamous cell carcinoma; Impact therapeutique de l'acquisition cervicale dediee en [{sup 18}F]-FDG-TEP-TDM sur la prise en charge des carcinomes epidermoides de la tete et du cou  

Energy Technology Data Exchange (ETDEWEB)

Aim of the study: To investigate the therapeutic impact of additional cervical dedicated {sup 18}F.D.G.-PET-CT on the management of head and neck squamous cell carcinoma (H.N.S.C.C.). Materials and methods: Thirty patients with H.N.S.C.C. underwent a [{sup 18}F]-F.D.G.-PET-CT standard, whole-body scan completed by a cervical dedicated protocol. Two physicians blindly reviewed the exams and the results were discussed with surgeons to determine the therapeutic impact of the dedicated protocol. Result: Among 30 patients, only four (13%) discordant results were registered by the both observers, and two more by only one observer (k = 0.75, S.D. = 0.08). As to the four patients: 1) a N0 staged patient on whole body (W.B.) exam was upstaged to N2b in cervical PET (obese patient, whole-body exam with poor quality), 2) for a second patient, no node was described on whole-body scan, but one lymph node in each cervical chain was observed in focused PET, with low standardized uptake value (S.U.V. value), 3) in the other two cases, cervical PET scan upstaged from N2a to N2b and from N2a to N2c (S.U.V. < 3), without any influence on treatment management. Conclusion: Our results show that additional cervical dedicated PET-CT does not modify the management of patients with H.N.S.C.C. when compared to whole-body PET-CT, except for particular obese or N0 patients, allowing to reduce patient CT radiation dose and time-consuming PET acquisition. (authors)

Queneau, M.; Tourdias, T.; Guyot, M.; Allard, M.; Fernandez, P. [CHU Pellegrin-Tripode, Service de Medecine Nucleaire, 33 - Bordeaux (France); Houliat, H. [CHU Pellegrin-Tripode, Service d' Oto-Rhino-Laryngologie et de Chirurgie Cervico-Faciale du Pr Bebear, 33 - Bordeaux (France)

2008-09-15

296

Check-up and follow-up of papillary and follicular thyroid carcinoma in the department of nuclear medicine at Ibn Sina hospital Rabat; Bilan et surveillance des carcinomes papillaire et vesiculaire de la thyroide dans le service de medecine nucleaire de l'hopital Ibn Sina de Rabat  

Energy Technology Data Exchange (ETDEWEB)

In the department of nuclear medicine at Ibn Sina university hospital. Thyroid carcinoma follow-up strategy has been modified and includes cervical ultrasonography and thyroglobulin measurement. The role of radio-iodine scanning in the management of differentiated thyroid carcinoma is decreasing. Papillary and follicular carcinoma have good prognosis but late metastases exist and can lead to death. A lifelong follow-up is therefore mandatory. The main goal of follow-up is to detect earlier persistent or recurrent disease. (authors)

Ben Rais Aouad, N.; Ghfir, I.; Guerrouj, H.; Fellah, S.; Rahali, J.; Ksyar, R.; Missoum, F.; Bssis, A.; Azrak, S. [CHU Ibn Sina, Service de Medecine Nucleaire, Rabat (Morocco)

2009-10-15

297

Survival over ten years after chemotherapy by paclitaxel and carboplatin, followed by a concomitant chemo-radiotherapy in nasopharyngeal undifferentiated carcinomas; Survie a dix ans apres chimiotherapie par paclitaxel et carboplatine, suivie d'une chimioradiotherapie concomitante dans les carcinomes indifferencies du nasopharynx  

Energy Technology Data Exchange (ETDEWEB)

Based on 28 patients suffering from a cavum carcinoma and having been treated by neo-adjuvant chemotherapy (with paclitaxel and carboplatin) followed by a concomitant chemo-radiotherapy and an adjuvant chemotherapy, the authors analyse the response over time and identify the main causes of death. They also conclude that randomized studies are necessary to better asses the treatment efficiency. Short communication

Djekkoun, R.; Ferdi, N.; Bouzid, K. [CHU de Constantine, Constantine (Algeria)

2011-10-15

298

Total encephalic radiotherapy and concomitant administering of trastuzumab for brain metastases of a mammary carcinoma with HER2 overexpression: experience of the Curie Institute; Radiotherapie encephalique totale et administration concomitante de trastuzumab pour des metastases cerebrales d'un carcinome mammaire surexprimant HER2: experience de l'institut Curie  

Energy Technology Data Exchange (ETDEWEB)

The authors report a retrospective study of assessment of the tolerance to and of the activity of the trastuzumab in association with a total encephalic irradiation. The study is based on 31 patients suffering from brain metastases in relationship with a mammary cancer with HER2 expression, and who have been submitted to a total encephalic radiotherapy with a trastuzumab treatment. This medicine appears to be efficient and harmless. A clinic trial should confirm these results. Short communication

Chargari, C.; Idrissi, H.R.; Pierga, J.Y.; Bollet, M.; Dieras, V.; Campana, F.; Cottu, P.; Fourquet, A.; Kirova, Y. [Institut Curie, 75 - Paris (France)

2010-10-15

299

Concurrent split-course chemotherapy and radiotherapy for unresectable stage 3 non-small cell lung cancer: results of a preliminary phase 2 study; Chimioradiotherapie en split course dans les carcinomes bronchiques non a petites cellules de stade 3: resultats preliminaires d'une etude de phase 2  

Energy Technology Data Exchange (ETDEWEB)

Purpose: we initiated at Hospital de Mulhouse a prospective phase II study to assess a split-course concurrent radio-chemotherapy in locally advanced non-small cell lung cancer. Materials and methods: from March 1996 to December 1997, 28 patients were included in our study. All patients had a stage III cancer. The chemotherapy scheduled included vinorelbine (20 mg/m{sup 2}/d, d1 and d5), cisplatin (20 mg/m{sup 2}/d, from d1 to d5), and 5-Fluorouracil (350 mg/m{sup 2}/d, from d1 to d5 by continuous infusion). The planned irradiation dose was 12.5 Gy per week with one daily fraction of 2.5 Gy from d1 to d5. Cycles were repeated every four weeks, for four cycles (50 Gy). Patients with a partial or complete response were proposed a fifth cycle. Results: of the 28 patients of the study, only 27 were analysed; one patient had a metastatic disease at diagnosis. Major hematologic toxicity occurred in 26% of the patients. One to five cycles of chemoradiotherapy were administrated per patient (median: four). Four patients had received fewer than three cycles and their responses were not assessable. Of the 23 patients assessed, 12 responses (52%) were observed, three CR (13%) and nine PR (39%). Median follow-up was 14 months, and median survival 13.5 months. One- and two-year survival rates were respectively 63%, and 14%. Local control rates was 11%, and 44% of the patients had a metastatic evolution. Conclusion: very preliminary results of this phase II study are disappointing, and quite inferior to the published results using chemoradiotherapy with conventional or hyperfractionated radiotherapy. Hematologic toxicity is restrictive. This type of chemoradiotherapy cannot be recommended. (author)

Benchalal, M.; Elgard Maitre, A.M.; Pignol, J.P.; Noirclerc, M.; Prevot, G. [Service d' oncoradiotherapie de Mulhouse, 68 (France); Bourderont, D. [Hopital du Hasenrain, 68 - Mulhouse (France); Salze, P. [Hopital Pasteur, 68 - Colmar (France); Bombaron, P.; Neidhardt, A.C.; Sizaret, O.; Newinger, G.; Zipper, J.M. [Centre Hospitalier de Mulhouse, 68 (France); Lambert, J.; Baumann, J.; Sabountchi, M. [Centre Medical Lalance, 68 - Lutterbach (France)

1999-12-01

300

Fluoro choline({sup 18}F) has a clinical usefulness in prostate cancer and in hepatocellular carcinoma sometimes in the same patient;La fluorocholine({sup 18}F) a une utilite clinique dans le cancer de la prostate et le carcinome hepatocellulaire parfois chez le meme malade  

Energy Technology Data Exchange (ETDEWEB)

Case report: In order to stage hepatocellular carcinoma (H.C.C.), a patient was referred to PET/CT using fluorodeoxyglucose({sup 18}F) (F.D.G.) and, if necessary, fluoro choline({sup 18}F) (F.C.H.). H.C.C. was proven by biopsy of a hepatic mass discovered on CT performed for a biological recurrence of prostate cancer. Result: F.D.G. PET/CT did not show any anomaly. F.C.H. PET/CT was thus performed and showed various foci: the hepatic mass, a large abdominal adenopathy and an unexpected sub centimeter lung nodule. The diagnostic uncertainty mostly concerned this lung nodule which was biopsied and consisted of a metastasis of the prostate cancer. Due to the presence of two metastatic cancers, the patient's management was altered, with chemotherapy for the H.C.C. and hormone therapy for the prostate cancer. Conclusion: Several types of cancer take-up fluoro choline({sup 18}F), which is a powerful tool to detect metastases, in particular in case of rising levels of marker with a negative F.D.G. PET/CT. Even when F.D.G. PET/CT is positive, F.C.H. may reveal unexpected foci with other metabolic characteristics, although it is not specific of a given primary cancer, as well as F.D.G.. For staging of H.C.C., we thus recommend to perform PET/CT with both tracers. (authors)

Balogova, S.; Kerrou, K.; Huchet, V.; Gutman, F.; Montravers, F.; Talbot, J.N. [Universite Pierre-et-Marie-Curie, Service de medecine nucleaire, hopital Tenon, AP-HP, 75 - Paris (France); Balogova, S. [Universite Comenius, Bratislava (Slovakia); Bumsel, F. [Universite Pierre-et-Marie-Curie, Service d' hepato-gastro-enterologie, hopital Saint-Antoine, AP-HP, 75 - Paris (France); Nataf, V. [Hopital Tenon, AP-HP, Radiopharmacie, 75 - Paris (France); Mal, F. [Institut mutualiste Montsouris, Departement de pathologie digestive, 75 - Paris (France)

2010-07-15

 
 
 
 
301

Interest of the SPECT-CT to D.M.S.A.-V images merging in the management of thyroid medullary carcinomas; Interets de la fusion d'image TEMP-TDM au DMSA-V dans la prise en charge des carcinomes medullaires de la thyroide  

Energy Technology Data Exchange (ETDEWEB)

Purpose: hybrid imaging associating SPECT and CT, integers functional and anatomical data. The aim of this communication is to present the contribution of the SPECT coupled to CT with D.M.S.A. V. in our daily practice of the medullary thyroid carcinomas management. Conclusions: the SPECT/CT got by a system of images merging allows a better anatomical location and improves the management of thyroid medullary carcinomas. (N.C.)

Menemani, A.; Mebarki, M.; Slama, A.; Khellil, N.; Meghelli, S.; Lachachi, B.; Krim, M.; Merad, S.; Berber, N. [CHU Tlemcen, Service de medecine nucleaire (Algeria)

2010-07-01

302

Conservative treatment of epidermoid carcinomas of the anal duct by external irradiation followed by low dose rate brachytherapy by iridium 192; Traitement conservateur des carcinomes epidermoides du canal anal par irradiation externe suivie de curietherapie de bas debit de dose par Iridium 192  

Energy Technology Data Exchange (ETDEWEB)

The association of external radiotherapy and brachytherapy is an efficient loco regional treatment of epidermoid carcinomas of the anal duct with an acceptable delayed toxicity rate and a high rate of the sphincter function conservation. (N.C.)

Minsat, M.; Moureau-Zabotto, L.; Giovannini, M.; Lelong, B.; Viret, F.; Bories, E.; Tallet, A.; Salem, N. [Institut Paoli-Calmettes, 13 - Marseille (France)

2007-11-15

303

Definitive treatment of anal canal carcinoma with radiotherapy: Adverse impact of a pre-radiation resection. A retrospective study of 57 patients treated with curative intent;Radiotherapie a visee curative du carcinome du canal anal: impact defavorable d'une resection prealable. Etude retrospective de 57 patients traites en intention curative  

Energy Technology Data Exchange (ETDEWEB)

Purpose To describe retrospectively the overall survival, the cancer specific survival and the tumor control in an homogeneous series of patients with epidermoid carcinoma of the anal canal treated with definitive radiotherapy; to assess the impact of brachytherapy, chemotherapy and pre-radiotherapy resection on the risk of recurrence. Patients and methods From 1997 to 2007, 57 patients (pts) presenting with an epidermoid carcinoma of the anal canal (T1: 14, T2: 33, T3-4: 10, N0: 31, N1: 19, N2: 3, N3: 4, M0: 57) were treated with definitive radiotherapy by the same radiation oncologist. The treatment included an external beam irradiation (E.B.R.T.) given to the posterior pelvis (45 Gy/25 fractions) and, six weeks later, a boost delivered with interstitial brachytherapy (37/57) or external beam irradiation (20/57). Twelve pts had undergone a surgical resection of the tumour before radiotherapy. A belly board was used for E.B.R.T. in 13 pts. A concurrent platinum based chemotherapy was done in 42 pts. The mean follow-up was 57 months. Results The overall survival rate at 5 years was 89% with a cause specific survival of 96%. Five patients recurred (5-year rate: 12%: four had local relapse (5-year rate: 8%), four had groin recurrence, and distant metastases were seen in two. In univariate analysis, the risk of relapse was higher in patients who had undergone a pre-radiation excision (p = 0.018), in those who did not receive chemotherapy (p = 0.076) and in those who were irradiated on a belly board (p = 0.049). In multivariate analysis, a pre-radiotherapy resection (p = 0.084) had an inverse impact on the tumour control reaching the level of statistical significance and the use of a belly board was of marginal influence (p = 0.13). Conclusion Radiotherapy and chemo radiation with cisplatin-based chemotherapy cure a vast majority of patients with epidermoid carcinoma of the anal canal. Therapeutic factors that may interfere with the definition of the target volume and the patients repositioning may decrease the efficacy of radiotherapy. Pre-radiotherapy surgical resection should be avoided

Coquard, R. [Centre de Radiotherapie Bayard, 69 - Villeurbanne (France); Cenni, J.C. [Clinique du Tonkin, 69 - Villeurbanne (France); Artru, P.; Lledo, G. [Hopital prive Jean-Mermoz, 69 - Lyon (France); Chalabreysse, P. [Centre de pathologie CY-PATH (Fondation Marcel-Merieux), 69 - Lyon (France); Queneau, P.E. [Hopital prive de l' Est Lyonnais, 69 -Saint-Priest (France); Taieb, S. [Centre hospitalier mutualiste des Portes-du-Sud, 69 - Feyzin (France); Alessio, A. [Clinique Trenel, 69 -Sainte-Colombe (France)

2009-12-15

304

Target volumes in radiotherapy - head and neck tumors intensity - Modulated radiation therapy (IMRT) of nasopharyngeal carcinoma: practical aspects in the delineation of target volumes and organs at risk; Radiotherapie conformationnelle avec modulation d'intensite (RCMI) des carcinomes du cavum: aspects pratiques de la delineation des volumes cibles et des organes critiques  

Energy Technology Data Exchange (ETDEWEB)

The objective of this paper is to give some practical landmarks for the delineation of target volumes and organs at risk in Intensity Modulated Radiation Therapy for Nasopharyngeal Carcinoma. This delineation, drawn from anatomo-clinical data, natural history of the disease and radiological pre-treatment evaluation, seems to be easier to define than the delineation of other head and neck cancer localizations (oropharynx and oral cavity for example). Experience inside national and international cooperative groups should tend to standardize this initial and fundamental step of Nasopharyngeal Conformal Radiotherapy. (authors)

Marcy, P.Y.; Bensadoun, R.J. [Centre Antoine-Lacassagne, 06 - Nice (France); Zhu, Y. [Centre du cancer, Huangzhou (China)

2005-06-15

305

Surgery for Sleep Apnea?  

Medline Plus

Full Text Available ... Apnea? HealthDay May 22, 2013 Related MedlinePlus Pages Children's Health Sleep Apnea Tonsils and Adenoids Transcript Obstructive ... their adenoids and tonsils removed right away. 464 children between the ages of 5 and 9 took ...

306

Laryngeal adenoidcystic carcinoma  

Directory of Open Access Journals (Sweden)

Full Text Available A 72 year old male patient was admitted with complaints of dyspnoeaa of two months? duration. On local examination of ?he larynx, a polypoidal growth was seen in the sub glottis. Biopsy report was adenoid cystic carcinoma. Total laryngectomy was carried out. Post-operative course was uneventful. Occurrence of adenoid cystic carcinoma in the region of sub glottis is rare.

Mankodi R; Shah R

1979-01-01

307

Immunohistochemical Features of Lacrimal Gland Epithelial Tumors.  

UK PubMed Central (United Kingdom)

PURPOSE: To investigate the immunohistochemical features of ocular adnexal pleomorphic adenoma and adenoid cystic carcinoma. DESIGN: Retrospective clinicopathologic study. METHODS: Clinical records and microscopic slides of 7 cases of each tumor type were reviewed. Immunohistochemical probes for Ki-67 and p53, and newer nuclear markers MYB for adenoid cystic carcinoma and PLAG1 for pleomorphic adenoma, were employed. RESULTS: Pleomorphic adenomas were asymptomatic, whereas adenoid cystic carcinomas were painful. No pleomorphic adenomas recurred; 4 adenoid cystic carcinomas recurred, resulting in 3 deaths. Unusual histopathologic variants for which immunohistochemistry proved useful included a myoepithelioma, an atypical pleomorphic adenoma, tubular and solid/basaloid variants of adenoid cystic carcinoma, and a morphologically heterogeneous adenoid cystic carcinoma of a Wolfring gland. For the pleomorphic adenomas, the average Ki-67 proliferation index was 3.8%; p53 was weakly staining, with an average positivity of 18.5%; PLAG1 was strongly positive in all cases; MYB was negative in 5 cases and weakly focally positive in 2 cases. For the adenoid cystic carcinomas, the average Ki-67 proliferation index was 29.1%; p53 stained positively and strongly with an average of 39%; none stained positively for PLAG1; and 6 out of 7 were MYB positive. CONCLUSIONS: Between pleomorphic adenoma and adenoid cystic carcinoma, there was no overlap in Ki-67 positivity. Positivity for p53 showed overlap in only one lesion of each type. PLAG1 and MYB positivity were highly discriminating between pleomorphic adenoma and adenoid cystic carcinoma. Immunohistochemical analysis should be investigated further for its role in the evaluation of pleomorphic adenoma and adenoid cystic carcinoma.

Mendoza PR; Jakobiec FA; Krane JF

2013-08-01

308

[Tumor cell separation by cell saver and membrane filter passage  

UK PubMed Central (United Kingdom)

Definite suspensions of malignant cells from three human tumor cells lines (bladder, prostate and renal cell carcinom) were passed through a cell saver (Althin Mediplast) and a leucozyte removal filter (PALL RC 100) under standard conditions. The examination of the solutions did not detect any malignant cells at all. If investigations with malignant cells in the blood will confirm these results, the use of intraoperative autotransfusion in urological tumor surgery would be possible.

Wiesel M; Güdemann C; Staehler G

1991-06-01

309

[Tumor cell separation by cell saver and membrane filter passage].  

Science.gov (United States)

Definite suspensions of malignant cells from three human tumor cells lines (bladder, prostate and renal cell carcinom) were passed through a cell saver (Althin Mediplast) and a leucozyte removal filter (PALL RC 100) under standard conditions. The examination of the solutions did not detect any malignant cells at all. If investigations with malignant cells in the blood will confirm these results, the use of intraoperative autotransfusion in urological tumor surgery would be possible. PMID:1917056

Wiesel, M; Güdemann, C; Staehler, G

1991-06-01

310

Long term follow-up in patients with a naso-pharynx carcinoma after induction chemotherapy by cisplatin, 5-fluoro-uracil and bleomycin (pbf) followed by a bi-fractionated radiotherapy and a consolidation chemotherapy; Survie a long terme chez des patients atteints d'un carcinome du nasopharynx apres chimiotherapie d'induction par cisplatine, 5-fluoro-uracile et bleomycine (pbf) suivie d'une radiotherapie bifractionnee et une chimiotherapie de consolidation  

Energy Technology Data Exchange (ETDEWEB)

The purpose of this study was to evaluate the efficiency and the long term survival after neoadjuvant chemotherapy by cisplatin, 5-fluoro-uracil and bleomycin, followed by a bi fractionated radiotherapy and an adjuvant chemotherapy. The protocol associating a P.B.F. type chemotherapy in the locally evolved disease is justified by its efficiency in terms of objective response rate and local control rate, that expressed by an improvement of the global survival rate and survival without disease at five and ten years. The adjuvant chemotherapy is very toxic and did not show any benefit. (N.C.)

Djekkoun, R.; Boudaoud, K.; Ferdi, N.; Filali, T. [CAC CHU, Constantine (Algeria)

2009-10-15

311

Usefulness of [{sup 18}F]-FDOPA PET as an adjunct to [{sup 18}F]-FDG PET in the imaging of small cell lung carcinoma. Preliminary results; La TEP a la [{sup 18}F]-FDOPA dans l'imagerie des carcinomes bronchiques a petites cellules: comparaison avec l'imagerie conventionnelle et la TEP au [{sup 18}F]-FDG. Resultats preliminaires  

Energy Technology Data Exchange (ETDEWEB)

Small Cell Lung carcinomas (SCLC) are tumours which express neuroendocrine markers. Dihydroxy-phenylalanine (DOPA) is known to accumulate in neuroendocrine tumours. It looked interesting to assess the ({sup 18}F)-FDOPA uptake by SCLC and to assess the role of ({sup 18}F)-FDOPA PET in SCLC imaging. A ({sup 18}F)-FDG PET was performed in 7 patients affected with SCLC. An additional ({sup 18}F)-FDOPA PET was performed in 4 of these patients and compared with standard staging procedures. Among the 7 patients, 4 were referred for initial staging, 2 for a suspicion of recurrence and 1 for a suspicion of persistent disease. In the 4 patients with an additional ({sup 18}F)-FDOPA PET, there was an agreement between ({sup 18}F)-FDG PET and standard imaging procedures in 9 tumours sites out of 9. On the other hand there was no agreement between ({sup 18}F)-FDOPA PET and ({sup 18}F)-FDG PET in 6 tumour locations out of 9. In 3 of the 4 patients, a relationship was found between ({sup 18}F)-FDOPA PET and the expression of neuroendocrine tumour markers in immunohistochemistry (IHC) (Chromogranin A, Synaptophysine and NCAM). ({sup 18}F)-FDOPA PET appeared less sensitive than FDG PET and standard imaging procedures in the staging of small cell lung carcinoma. However, a relationship seemed to exist between positivity in IHC and ({sup 18}F)-FDOPA uptake, but this has to be assessed in larger series of patients. This relationship could have further applications in the search for a subgroup of SCLC patients with a better tumour differentiation and perhaps a better prognosis. (authors)

Jacob, T.; Grahek, D.; Kerrou, K.; Aide, N.; Montravers, F.; Younsi, N.; Balogova, S.; Beco, V. de; Colombet, C.; Talbot, J.N. [Hopital Tenon, Service de Medecine Nucleaire, et Centre TEP AP-HP, 75 - Paris (France)

2003-07-01

312

Analysis of the role of the gene coding the Amyloid-Precursor Protein Binding Protein 1 (APP-BP1) in the radio-sensitivity of epidermoid carcinomas of the upper aero-digestive tract infected by the human papillomavirus; Analyse du role du gene codant l'Amyloid-Precursor Protein Binding Protein 1 (APP-BP1) dans la radiosensibilite des carcinomes epidermoides des voies aero-digestives superieures infectees par le papillomavirus humain  

Energy Technology Data Exchange (ETDEWEB)

As the human papillomavirus (HPV) is at the origin of 25% of upper aero-digestive tract cancers, and as these tumours present an increased radio-sensitivity compared to other tumours, probably due to a greater transcriptional activity of p53, the authors report the study on the influence of a decrease of the expression of the APP-BP1 in these tumours which could favour a radio-induced apoptosis. By using a reverse transcriptase polymerase chain reaction (RT-PCR), they assessed the APP-BP1 expression levels as well as expression levels of transcriptions coding onco-proteins known to be over-expressed in HPV+ tumours. They compared the radio-sensitivities of HPV+ and HPV- cells, the first one appearing to be greater than the second one. Short communication

Guihard, S.; Altmeyer, A.; Ramolu, L.; Macabre, C.; Abecassis, J.; Noel, G.; Jung, A.C. [Centre de lutte contre le cancer Paul-Strauss, 67 - Strasbourg (France)

2010-10-15

313

Genetic determinants of Pseudomonas aeruginosa colonization in cystic fibrosis patients in Canada.  

Science.gov (United States)

The present study was aimed at analyzing whether the rate of colonization and the age at colonization with Pseudomonas aeruginosa was genetically determined in cystic fibrosis (CF) patients. These two variables were calculated among 127 CF patients whose genotypes were known and who were monitored at the Clinique de Fibrose Kystique in Saguenay Lac-Saint-Jean. No statistically significant differences were found in the rate or the age at colonization when the patients were grouped by genotype; however, this result could be due to the small number of patients in each genotype group. The rate of colonization was significantly lower among CF patients carrying the A455E mutation, a "mild" allele with respect to exocrine pancreatic function, than among those carrying either the deltaF508 or the 621 + IG- > T mutation, both of which are "severe" alleles. The results confirm previous reports that the rate of colonization with Pseudomonas aeruginosa is, at least in part, genetically determined. PMID:9707310

De Braekeleer, M; Allard, C; Leblanc, J P; Aubin, G; Simard, F

1998-04-01

314

Tonsillectomy and Adenoidectomy  

Medline Plus

Full Text Available ... Enlarged tonsils or adenoids can lead to difficulty breathing while sleeping. This condition is known as obstructive ... on the basis of: • A history of difficulty breathing while sleeping and • A physical exam that shows ...

315

Tonsillectomy and Adenoidectomy  

Medline Plus

Full Text Available ... for adults as well. Tonsillectomy and adenoidectomy, or T&A, can help to prevent frequent sore throats ... the adenoids. The combined operation is called a T&A. The surgeon may decide to do one ...

316

Management of difficult airway by retrograde tracheal intubation  

International Nuclear Information System (INIS)

A case of difficult intubation is presented in a patient of adenoid carcinoma with a large right-sided facial defect. She was managed with radiotherapy and a myocutaneous flap reconstruction was done with retrograde tracheal intubation. (author)

2003-01-01

317

Oral Cancer Removal and Palate Reconstruction  

Medline Plus

Full Text Available ... of the trigeminal nerve toward the brain. 00:13:55 Adenoid cystic carcinoma is particularly difficult to ... a donor site morbidity and recovery. 00:45:13 J. DALE BROWNE, M.D.: Chris, I could---- ...

318

Surgery for Sleep Apnea?  

Medline Plus

Full Text Available ... upper airway. Causes include enlarged tonsils and adenoids, obesity or other medical problems. Kids with sleep apnea ... surgery. Nearly half the children were overweight or obese. Those who had the surgery showed improvements in ...

319

Immunohistochemical study of androgen, estrogen and progesterone receptors in salivary gland tumors  

Scientific Electronic Library Online (English)

Full Text Available Abstract in english The aim of this work was to study the immunohistochemical expression of androgen receptor, estrogen receptor and progesterone receptor in pleomorphic adenomas, Warthin's tumors, mucoepidermoid carcinomas and adenoid cystic carcinomas of salivary glands. A total of 41 pleomorphic adenomas, 30 Warthin's tumors, 30 mucoepidermoid carcinomas and 30 adenoid cystic carcinomas were analyzed, and the immunohistochemical expression of these hormone receptors were assessed. It was (more) observed that all cases were negative for estrogen and progesterone receptors. Androgen receptor was positive in 2 cases each of pleomorphic adenoma, mucoepidermoid carcinoma and adenoid cystic carcinoma. In conclusion, the results do not support a role of estrogen and progesterone in the tumorigenesis of pleomorphic adenomas, Warthin's tumors, mucoepidermoid carcinomas and adenoid cystic carcinomas. However, androgen receptors can play a role in a small set of salivary gland tumors, and this would deserve further studies.

Ito, Fabio Augusto; Ito, Kazuhiro; Coletta, Ricardo Della; Vargas, Pablo Agustín; Lopes, Márcio Ajudarte

2009-12-01

320

Immunohistochemical characterisation of extracellular matrix components of salivary gland tumours.  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Proteoglycans (PGs) were localised immunohistochemically in 52 salivary gland tumours including pleomorphic adenoma, adenoid cystic carcinoma, acinic cell carcinoma, oncocytoma, mucoepidermoid carcinoma, clear cell tumour and Warthin tumour, using antibodies raised against large PG, small PG, chondr...

Nara, Y.; Takeuchi, J.; Yoshida, K.; Fukatsu, T.; Nagasaka, T.; Kawaguchi, T.; Meng, N.; Kikuchi, H.; Nakashima, N.

 
 
 
 
321

Tonsillectomy and Adenoidectomy  

Medline Plus

Full Text Available ... infections or inflammation. This can sometimes lead to hearing loss. Symptoms & Causes The most common reason that ... adenoids and clogged Eustachian tubes, can lead to hearing loss. Sometimes hearing loss can cause speech problems. ...

322

Tonsillectomy and Adenoidectomy  

Medline Plus

Full Text Available ... middle ear infections or inflammation. This can sometimes lead to hearing loss. Symptoms & Causes The most common ... to swollen adenoids and clogged Eustachian tubes, can lead to hearing loss. Sometimes hearing loss can cause ...

323

Tonsillectomy and Adenoidectomy  

Medline Plus

Full Text Available ... the immune system and help fight infections. Eustachian tube The adenoids are located behind the soft palate. ... connects the nose to the mouth. The Eustachian tubes connect the middle ear to the back of ...

324

Your Tongue  

Science.gov (United States)

... your lingual tonsil that's infected. Tonsillitis affects the palatine (say: pah -luh-tyne) tonsils , which are two ... side of the tongue. The lingual tonsil, the palatine tonsils, and the adenoids are part of a ...

325

Prospective study of factors of prognosis of survival without disease and of global five year and ten-year survival in a series of 90 patients suffering from a stage IIB or III cervical epidermoid carcinoma which had been treated by concomitant chemo-radiotherapy; etude prospective des facteurs pronostiques de survie sans maladie et de survie globale a cinq et dix dans une serie de 90 patientes atteintes d'un carcinome epidermoide du col uterin de stade IIB ou III dont le traitement etait une chimioradiotherapie concomitante  

Energy Technology Data Exchange (ETDEWEB)

The authors report the study of some factors (TNM stage, tumour size, histological sub-type and haemoglobin concentration) of survival without disease and of global survival by analyzing the files of 90 patients who had chemotherapy concomitantly with external radiotherapy (five 1,8 Gy sessions a week for four to five weeks) followed by utero-vaginal curietherapy. It appears that chemo-radiotherapy is well tolerated and that some factors very significantly affect global survival and survival without disease. Concomitant chemo-radiotherapy significantly delays the occurrence of recurrence and metastases, notably for locally advanced tumours. Short communication

Ferdi, N.; Djekkoun, R.; Aouati, E.; Chirouf, A.; Aouati, S.; Afiane, M. [CHU de Constantine (Algeria)

2011-10-15

326

Cell cycle break and apoptosis induction for the HPV-18 positive human head and neck carcinomas lines, after exposure to 5-fluorouracils and ionizing radiations:NF-kB implication in the radiosensitivity and spontaneous apoptosis; Arrets du cycle cellulaire et induction d'apoptose pour les lignees de carcinome humain de la tete et du cou HPV-18 positives, apres exposition au 5-fluorouracile et aux radiations ionisantes: implication de NF-kB dans la radiosensibilite et l'apoptose spontanee  

Energy Technology Data Exchange (ETDEWEB)

The P-53 protein holds an important contribution in the control of the cell cycle as well as the apoptosis control. But in numerous cancers the P-53 protein functionality is blocked by mutations or by its gene obliteration. The distribution of cells in the cell cycle as well as the apoptosis induction have been studied after exposure to 5-Fluorouracils (5-F.U.) or ionizing radiations. The two types of stress can induce dependent P-53 apoptosis after 5-F.U. exposure and independent P-53 apoptosis after ionizing radiation exposure. The P-53 protein is not the only one to have an important part in the cell cycle and apoptosis control, the transcription factor is important as well as the cells sensitivity to a stress such ionizing radiation. This could open new approaches of increasing the biological effects of ionizing radiations. (N.C.)

Didelot, C

2002-04-15

327

Use of narrow-band imaging in detection of nasopharyngeal carcinoma.  

UK PubMed Central (United Kingdom)

Aim: To compare narrow-band images of nasopharyngeal carcinoma with those of normal adenoidal tissue. Method: Patients with a nasopharyngeal mass were evaluated using both conventional white light and narrow-band light. Biopsies were performed and Epstein-Barr viral serology was tested for all patients. Results: Thirty consecutive patients were recruited. Twenty-one patients had normal adenoidal tissue and seven had nasopharyngeal carcinoma. One patient with papillary adenocarcinoma was excluded. The features of narrow-band imaging in normal adenoidal tissue were: (1) a regularly arranged follicular pattern, and (2) each 'follicle' comprising a pale centre with surrounding dark periphery. The features of narrow-band imaging in nasopharyngeal carcinoma were: (1) absence of surface patterns (n = 7), and/or (2) 'reverse', haphazard follicular pattern comprising a dark brown centre and pale periphery (n = 3). Conclusion: Narrow-band imaging of the surface of adenoidal tissue and nasopharyngeal carcinoma appears to identify distinct, characteristic features as described. Narrow-band imaging may be a useful adjunct in differentiating normal adenoidal tissue from malignancy. Further studies are needed to evaluate its diagnostic accuracy.

Thong JF; Loke D; Karumathil Sivasankarannair R; Mok P

2013-01-01

328

HYPERTROPHICALUM ADENOIDIS IN RE-LATIUM CUM SECRETUM OTTITIS IN MEDIAM  

Directory of Open Access Journals (Sweden)

Full Text Available In this study we presented the treatment of 20 children with secretory otitis media (SOM). The treatment was surgical and it considened-ventilaton tube insertion and adenoidectomy in case of enlarged adenoid. In this clinical investigation was enroll 15 boys and 5 girls in age 5 to 10 were divided in two main groups:1. 9 children without enlarged adenoid2. 11 children with confirmed enlarged adenoidClinical material was analyzed according to hearing level, middle ear condition estimated by pure toneaudiiometry and tympanometry before and after the treatment. The result showed that adenoidectomy in combination with ventilation tube insertion facilitate secretory otitis media. That’s enable timely improving of hearing function us a important on development of speech, social, emotional and academic development in the early childhood.

Lidija DUBROVSKA-MILETIC; Marina DAVCEVA-CAKAR

1999-01-01

329

JCV/BKV and SV40 viral load in lymphoid tissues of young immunocompetent children from an area of north-east Italy.  

UK PubMed Central (United Kingdom)

Polyomavirus infection occurring during childhood is followed by a lifelong latency in immunocompetent subjects. The major site of polyomavirus persistence are the uroepithelial cells which leads to oral transmission. It has recently been hypothesized that tonsils could be a possible reservoir. The role of tonsil, adenoid, and peripheral blood mononuclear cells (PBMCs) as possible sites of JCV, BKV, and SV40 latency in young healthy children was assessed. Two hundred fifteen fresh specimens, including 57 tonsil, 80 adenoid, and 78 PBMC samples from 80 immunocompetent children (mean age 4.8 years) were analyzed to determine the viral load by quantitative real-time PCR. The human herpes virus 6 (HHV-6) was tested as a lymphotropic reference virus. Polyomavirus was detected in 5/80 (6.2%) children while HHV-6 infection affected 27/80 children (33.7%) (P < 0.001). SV40 was detected in one adenoid sample, while footprints of BKV were found in one adenoid and three tonsil samples. JCV was never found in all samples. Polyomavirus sequences were not detected in the 78 blood samples. One adenoid and two tonsils from three children (1.4%) were positive for both polyomavirus and HHV-6. Infections were characterized by low replication rates ranging typically from 1 x 10e(2)/5.5 x 10e(4) to 6.8 x 10e(3)/8.5 x 10e(4) viral copies/number of cells. In conclusion, tonsils and adenoids of children could effectively harbor BKV and SV40, although only very few cells proved to be infected. Nevertheless, the low prevalence of polyomavirus, in comparison with the lymphotropic HHV-6, suggests that these tissues are unlikely to be the preferred site of polyomavirus latency, at least in younger children.

Comar M; Zanotta N; Bovenzi M; Campello C

2010-07-01

330

Salivary gland-like tumors of the breast express basal-type immunohistochemical markers.  

UK PubMed Central (United Kingdom)

BACKGROUND: Salivary gland-like tumors represent approximately 2% of primary breast carcinomas. These special histologic subtypes are characteristically negative for ER, PR, and HER2 (triple negative), and include adenoid cystic carcinoma, mucoepidermoid carcinoma, acinic cell carcinoma, and polymorphous low-grade adenocarcinoma. Approximately 75% of triple-negative breast carcinomas belong to the basal-like subtype by gene expression profiling. Immunohistochemical panels that include basal-like markers such as EGFR, CK5/6, p-cadherin, p63, and c-kit provide useful surrogates to gene expression arrays for classification of triple-negative breast cancers into the basal-like subtype. The purpose of this study was to explore the expression of these markers in salivary gland-like tumors of the breast. DESIGN: Excisional specimens from 10 untreated invasive triple-negative mammary carcinomas with salivary gland-like morphologies were evaluated for the immunohistochemical expression of EGFR, CK5/6, p-cadherin, p63, and c-kit using formalin-fixed, paraffin-embedded tissue and the L-SAB detection method. RESULTS: On the basis of morphology, 5 carcinomas were classified as adenoid cystic, 3 as mucoepidermoid, and 2 as polymorphous low grade. All of the adenoid cystic carcinomas, mucoepidermoid carcinomas, and polymorphous low-grade adenocarcinomas showed strong and diffuse expression of CK5/6, p-cadherin, and p63. EGFR was expressed weakly in adenoid cystic carcinomas and polymorphous low grade, whereas mucoepidermoid carcinomas had a stronger expression. C-kit was expressed in adenoid cystic carcinomas and low-grade polymorphous, but only weakly positive in mucoepidermoid carcinomas. CONCLUSIONS: Adenoid cystic, mucoepidermoid, and polymorphous low-grade carcinomas of the breast express immunohistochemical markers that characterize the intrinsic basal-like subtype of breast cancer.

Reyes C; Jorda M; Gomez-Fernández C

2013-07-01

331

A solitary tonsil can cause severe obstructive sleep apnea.  

UK PubMed Central (United Kingdom)

Hypertrophy of the tonsils and adenoids is the most common cause of pediatric obstructive sleep apnea. Bilateral tonsillectomy, most commonly performed with adenoidectomy, is the accepted treatment for obstructive sleep apnea. We report the unusual case of a child who underwent unilateral tonsillectomy and adenoidectomy at another institution and subsequently presented to us with persistent severe obstructive sleep apnea and a diagnosis of attention deficit hyperactivity disorder. The adenoids were not obstructing the choanae. The remaining tonsil was removed and the patient's sleep apnea resolved. This is the first objectively documented report of a solitary tonsil causing severe obstructive sleep apnea (using polysomnography) that resolved after removal of the remaining tonsil.

Sklar MC; Narang I; Ngan BY; Propst EJ

2013-07-01

332

Posterior plica synechia: rare complication of adenotonsillectomy.  

UK PubMed Central (United Kingdom)

Tonsillectomy is one of the most common operations performed by otolaryngologists. Fever, otalgia, dehydration, sore throat, and hemorrhage are common complications. In this clinical report, a 7-year-old boy was presented with a synechia between the posterior plicae together with recurrence of adenoid hypertrophy after adenotonsillectomy 1 year previously. The synechia and adenoid were resected, and the patient was discharged from the hospital after 2 days. The complication in this case was most likely caused by traumatic injury of the posterior plicae during the previous tonsillectomy. This complication is, however, very rare.

Çiçek MT; Croo A; Kizilay A

2012-07-01

333

Posterior plica synechia: rare complication of adenotonsillectomy.  

Science.gov (United States)

Tonsillectomy is one of the most common operations performed by otolaryngologists. Fever, otalgia, dehydration, sore throat, and hemorrhage are common complications. In this clinical report, a 7-year-old boy was presented with a synechia between the posterior plicae together with recurrence of adenoid hypertrophy after adenotonsillectomy 1 year previously. The synechia and adenoid were resected, and the patient was discharged from the hospital after 2 days. The complication in this case was most likely caused by traumatic injury of the posterior plicae during the previous tonsillectomy. This complication is, however, very rare. PMID:22801132

Çiçek, Mehmet T; Croo, Alexander; Kizilay, Ahmet

2012-07-01

334

Genotype-phenotype correlation in cystic fibrosis patients compound heterozygous for the A455E mutation.  

Science.gov (United States)

Cystic fibrosis (CF) has a high incidence in the French-Canadian population of Saguenay Lac-Saint-Jean (Quebec). The A455E mutation accounts for 8.3% of the CF chromosomes. This mutation was shown to be associated with a milder lung disease in the Dutch population. Twenty two CF patients distributed in 17 families and compound heterozygotes for the A455E mutation have been followed at the Clinique de Fibrose Kystique de Chicoutimi. Fourteen patients also carried the delta F508 mutation while the remaining eight patients had the 621 + 1G-->T mutation. Each patient was matched by sex and age to a patient homozygous for the delta F508 mutation. The pairs were analyzed for several clinical and laboratory variables. The A455E compound heterozygotes were diagnosed at a later age (P = 0.003) and had chloride concentrations at the sweat test lower than those homozygous for the delta F508 mutation (P = 0.007). More patients were pancreatic sufficient (P = 0.004). They had a higher Shwachman score (P = 0.001) and better pulmonary function tests (P < 0.02). CF patients compound heterozygous for the A455E mutation have a milder pancreatic and lung disease than the delta F508 homozygotes. Therefore, the A455E should be associated with a better prognosis. PMID:9402971

De Braekeleer, M; Allard, C; Leblanc, J P; Simard, F; Aubin, G

1997-12-01

335

Oral Cancer Removal and Palate Reconstruction  

Medline Plus

Full Text Available ... an adenoid cystic carcinoma from the hard palate… [clears throat]…of a patient here in the…at ... molar. And typically, after resection, we go ahead…[clears throat]…and we’re left with a large ...

336

Dasatinib in Treating Patients With Recurrent or Metastatic Malignant Salivary Gland Tumors  

Science.gov (United States)

High-grade Salivary Gland Mucoepidermoid Carcinoma; Low-grade Salivary Gland Mucoepidermoid Carcinoma; Recurrent Salivary Gland Cancer; Salivary Gland Acinic Cell Tumor; Salivary Gland Adenocarcinoma; Salivary Gland Adenoid Cystic Carcinoma; Salivary Gland Anaplastic Carcinoma; Salivary Gland Malignant Mixed Cell Type Tumor; Salivary Gland Poorly Differentiated Carcinoma; Salivary Gland Squamous Cell Carcinoma; Stage IV Salivary Gland Cancer

2013-09-04

337

C-type lectin receptors mRNA expression in patients with otitis media with effusion.  

UK PubMed Central (United Kingdom)

OBJECTIVE: The role of C-type lectin receptor, a type of pattern recognition receptor, in otitis media with effusion (OME) is unclear. We assayed the levels of expression of C-type lectin receptor mRNA in children with OME and evaluated its relationship to the presence of bacteria, accompanying diseases, and characteristics of exudates. SUBJECTS AND METHODS: The study population consisted of 73 children with OME who had undergone ventilating tube insertion. The levels of expression of Dectin-1, MR1, MR2, DC-SIGN, Syk, Card-9, Bcl-10, Malt-1, Src, Dec-205, Galectin-1, Tim-3, Trem-1, and DAP-12 mRNA in middle ear effusion were determined by real-time PCR. The level of expression of each mRNA was correlated with the presence of bacteria, accompanying diseases, and exudates characteristics. RESULTS: The levels of expression of C-type lectin receptor mRNAs were not associated with bacterial presence or exudates characteristics (p>0.05 each). Levels of expression, however, were significantly higher in patients with sinusitis, adenoid vegetation or adenoiditis, and allergic rhinitis (p<0.05 each). CONCLUSIONS: Levels of expression of C-type lectin receptor mRNA may be associated with the pathogenesis of OME, being significantly higher in patients with than without accompanying sinusitis, adenoid vegetation or adenoiditis, and allergic rhinitis.

Lee JH; Park DC; Oh IW; Kim YI; Kim JB; Yeo SG

2013-09-01

338

[Beta-hemolytic streptococci in tonsil hypertrophy and recurrent tonsillitis  

UK PubMed Central (United Kingdom)

BACKGROUND: The recurrence of streptococci acute tonsillitis is a complication that often motivates the tonsillectomy. We studied the colonisation of tonsils and adenoids by S. pyogenes and other beta haemolytic streptococci in both surgical indications, recurrent tonsillitis and tonsillar hypertrophy. METHODS: We made for aerobic culture the following specimens, throat swabs, tonsils and adenoids tissue corresponding to 47 children referred for tonsillectomy. RESULTS: S. pyogenes was isolated in 11 cases (23.4%) of tonsils and other beta haemolytic non A streptococci was isolated in 11 cases, of them, group C streptococci was the most frequent with six cases. However in the recurrent tonsillitis group, S. pyogenes was isolated more significantly (47%) that other beta haemolytic streptococci (5.8%). Otherwise in the tonsilar hypertrophy group, S. pyogenes was isolated in the 10% while that other streptococci was isolated in the 33.3%. The culture of 38 adenoids yielded S. pyogenes and beta haemolytic group C streptococci in 6 cases each one (15.7%). CONCLUSIONS: S. pyogenes was isolated more frequently in recurrent tonsillitis that other micro-organisms while that in the tonsilar hypertrophy group predominated streptococci beta haemolytic non A, S. aureus and H. influenzae. Is of interest that the adenoids in our study showed an important reservoir of beta haemolytic streptococci. The throats swabs yielded less of the half of all beta haemolytic streptococci isolated in tonsilar tissue cultured.

Ramírez A; Peidrola D; López A; Martínez MD; Ros MJ; Corral JL; Arteaga E

1997-06-01

339

Esophagoscopy in Evaluating Treatment in Patients With Stage I-IV Head and Neck Cancer Who Are Undergoing Radiation Therapy and/or Chemotherapy  

Science.gov (United States)

Stage I Adenoid Cystic Carcinoma of the Oral Cavity; Stage I Mucoepidermoid Carcinoma of the Oral Cavity; Stage I Squamous Cell Carcinoma of the Hypopharynx; Stage I Squamous Cell Carcinoma of the Larynx; Stage I Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage I Verrucous Carcinoma of the Larynx; Stage I Verrucous Carcinoma of the Oral Cavity; Stage II Adenoid Cystic Carcinoma of the Oral Cavity; Stage II Mucoepidermoid Carcinoma of the Oral Cavity; Stage II Squamous Cell Carcinoma of the Hypopharynx; Stage II Squamous Cell Carcinoma of the Larynx; Stage II Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage II Verrucous Carcinoma of the Larynx; Stage II Verrucous Carcinoma of the Oral Cavity; Stage III Adenoid Cystic Carcinoma of the Oral Cavity; Stage III Mucoepidermoid Carcinoma of the Oral Cavity; Stage III Squamous Cell Carcinoma of the Hypopharynx; Stage III Squamous Cell Carcinoma of the Larynx; Stage III Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage III Verrucous Carcinoma of the Larynx; Stage III Verrucous Carcinoma of the Oral Cavity; Stage IV Adenoid Cystic Carcinoma of the Oral Cavity; Stage IV Mucoepidermoid Carcinoma of the Oral Cavity; Stage IV Squamous Cell Carcinoma of the Hypopharynx; Stage IV Squamous Cell Carcinoma of the Larynx; Stage IV Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage IV Verrucous Carcinoma of the Larynx; Stage IV Verrucous Carcinoma of the Oral Cavity

2012-04-09

340

Mucoepidermoid carcinoma of the lung: a case report  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Abstract Mucoepidermoid carcinoma of the lung (MEC) is a tumor of low malignant potential of bronchial gland origin. MEC and adenoid cystic carcinoma are both considered to be salivary gland-type neoplasms. MECs are comparatively rare with an incidence of all lung cancers. We recently enco...

Kitada Masahiro; Matsuda Yoshinari; Sato Kazuhiro; Hayashi Satoshi; Ishibashi Kei; Miyokawa Naoyuki; Sasajima Tadahiro

 
 
 
 
341

Mucoepidermoid carcinoma of the lung: a case report  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Mucoepidermoid carcinoma of the lung (MEC) is a tumor of low malignant potential of bronchial gland origin. MEC and adenoid cystic carcinoma are both considered to be salivary gland-type neoplasms. MECs are comparatively rare with an incidence of all lung cancers. We recently encountered a case of t...

Kitada, Masahiro; Matsuda, Yoshinari; Sato, Kazuhiro; Hayashi, Satoshi; Ishibashi, Kei; Miyokawa, Naoyuki; Sasajima, Tadahiro

342

An Evaluation on the Importance of Phosphotungstic Acid Haematoxyiin (PTAH) Staining in Differential Diagnosis of Salivary Gland Neoplasms  

Digital Repository Infrastructure Vision for European Research (DRIVER)

The differential diagnosis between pleomorphic adenoma, the most common salivary gland neoplasm, microscopically, and two other common salivary gland neoplasms, meaning adenoid cystic carcinoma and mucoepidermoid carcinoma, is difficut.The purpose of this study was to determine the differences betwe...

F Baghaie Naeini; E Yazdi; M Seyed Majidi

343

The galea fascia flap in orbital reconstruction: Innovative harvest technique  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Aim: To report the treatment of a recurrent adenoid-cystic carcinoma of the lacrimal gland required orbital exenteration with an en bloc resection of the lateral orbital rim and wall and an anterior portion of the temporal muscle. Reconstruction was planned with both the objectives of a shortened he...

Zwahlen, RA; Grätz, KW; Obwegeser, JA

344

Upper airway obstruction and the pharyngeal lymphoid tissue.  

Science.gov (United States)

Enlarged tonsils and adenoids can cause chronic upper airway obstruction that may result in a spectrum of clinical findings ranging from sleep apnea to cor pulmonale and right heart failure. The clinical findings associated with this entity are reversible if the condition is identified early and removal of the obstructing tissue is performed before life-threatening changes occur. PMID:3299207

Yonkers, A J; Spaur, R C

1987-05-01

345

Upper airway obstruction and the pharyngeal lymphoid tissue.  

UK PubMed Central (United Kingdom)

Enlarged tonsils and adenoids can cause chronic upper airway obstruction that may result in a spectrum of clinical findings ranging from sleep apnea to cor pulmonale and right heart failure. The clinical findings associated with this entity are reversible if the condition is identified early and removal of the obstructing tissue is performed before life-threatening changes occur.

Yonkers AJ; Spaur RC

1987-05-01

346

Effect of etiology of mouth breathing on craniofacial morphology  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Introduction: Nasal septal deviation and hypertrophy of the adenoids and palatine tonsils are two common causes of nasopharyngeal obstruction and consequently mouth breathing in children. It is accepted that chronic mouth breathing influences craniofacial growth and development. The aim of this stud...

Mohammadreza Majidi; Nadia Hasanzadeh; Navid Noorizadeh; Mohammad taghi Shakeri

347

Subglottic carcinoma treated with surgery and adjuvant photodynamic therapy.  

Science.gov (United States)

Subglottic cancers are extremely rare as a primary malignancy representing <8% of all laryngeal cancers. Typical age at presentation is in the 5th decade. There are three main types of subglottic carcinoma: adenocarcinoma, mucoepidermoid and adenoid cystic carcinoma. We present a rare case of subglottic cancer treated with surgery and adjuvant photodynamic therapy. PMID:21112552

Nhembe, Farai; Jerjes, Waseem; Upile, Tahwinder; Hamdoon, Zaid; Vaz, Francis; Hopper, Colin

2010-09-09

348

Compound for cancer imaging and therapy  

Energy Technology Data Exchange (ETDEWEB)

The present invention relates to compounds having affinity for certain cancer cells, e.g. lung carcinomas, colon carcinoms, malignant melanomas, neuroblastomas and pheochromocytomas. The compounds also bind with high specificity to cell surface receptors and can therefore be used for diagnostic imaging of any tissue having an abundance of cells with sigma receptors. The compounds are of a general formula wherein X is a radionuclide, R{sub 2} is -N(R{sub 3}){sub 2} or a 5 to 6 member nitrogen containing heterocyclic ring, optionally substituted with at least one alkyl group. Methods are provided for diagnostic imaging and for the detection and treatment of tumors containing the cancer cells described above. (author).

John, C.S.; Baumgold, J.; McAfee, J.G.; Moody, T.W.

1993-05-06

349

Compound for cancer imaging and therapy  

International Nuclear Information System (INIS)

The present invention relates to compounds having affinity for certain cancer cells, e.g. lung carcinomas, colon carcinoms, malignant melanomas, neuroblastomas and pheochromocytomas. The compounds also bind with high specificity to cell surface receptors and can therefore be used for diagnostic imaging of any tissue having an abundance of cells with sigma receptors. The compounds are of a general formula wherein X is a radionuclide, R2 is -N(R3)2 or a 5 to 6 member nitrogen containing heterocyclic ring, optionally substituted with at least one alkyl group. Methods are provided for diagnostic imaging and for the detection and treatment of tumors containing the cancer cells described above. (author).

1994-11-24

350

Highly pathogenic avian influenza A virus H5N1 NS1 protein induces caspase-dependent apoptosis in human alveolar basal epithelial cells  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background It is widely considered that the multifunctional NS1 protein of influenza A viruses contributes significantly disease pathogenesis by modulating a number of virus and host-cell processes, but it is highly controversial whether this non-structural protein is a proapoptotic or antiapoptotic factor in infected cells. Results NS1 protein of influenza A/chicken/Jilin/2003 virus, a highly pathogenic H5N1 strain, could induce apoptosis in the carcinomic human alveolar basal epithelial cells (A549) by electron microscopic and flow cytometric analyses. NS1 protein-triggered apoptosis in A549 cells is via caspase-dependent pathway. Conclusions Influenza A virus NS1 protein serves as a strong inducer of apoptosis in infected human respiratory epithelial cells and plays a critical role in disease pathogenesis.

Zhang Chuanfu; Yang Yutao; Zhou Xiaowei; Liu Xuelin; Song Hongbin; He Yuxian; Huang Peitang

2010-01-01

351

Effects of adenoidectomy and immediate orthodonthic treatment on jaw relations and naso-respiratory rehabilitation  

Directory of Open Access Journals (Sweden)

Full Text Available Aim. To determine if adenoidectomy itself could provide spontaneous relation of the transverse growth of jaws as well as an adequate mode of breathing or if there is a need for an additional orthodontic treatment to solve the problem. Methods. The study included one hundred and one patients aged 6-17 yrs., divided into three groups: group K - patients with oral respiration caused by adenoidal enlargement; group 1 - patients with adenoidectomy done 5 or more years before; group 2 - patients with orthodontic treatment done immediately after adenoidectomy. Transverse occlusion relation, the frequency of crossbite, and the intensity of nasal respiration were measured in all three groups of patients. Results. The obtained results have shown that in the patients with adenoidal enlargement and oral respiration, there was an evidence of maxillary width reduction as opposed to mandibular width. Of the patients, 14% were with unilateral or bilateral crossbite. In the patients with adenoidectomy done 5 or more years before, transverse maxillary growth compared to mandibular one in the region of the front width, showed statistically significant increase (p < 0.05) as opposed to the patients with adenoidal enlargement. The effect of adenoidectomy on transverse maxillary growth was not satisfactory anyway, which was also indicated by the increase of frequency of crossbite in 24% of the patients with adenoidectomy done 5 or more years before. In operated on and in the patients one month after orthodontic treatment, transverse maxillary growth compared to mandibular growth in all the regions of both front and back width, there was statistically highly significant increase (p < 0.01) as opposed to the patients with adenoidal enlargement and adenoidectomy done many years before. Significant maxillary and mandibular transverse relation was obtained without the presence of crossbite. Nasal respiration prevailed. Conclusion. Orthodontic therapy one month after adenoidectomy was necessary for solving the orthodontic problems caused by adenoidal enlargement and significantly contributed to the rehabilitation of nasal respiration.

Mili? Jasmina ?.; Nikoli? Predrag V.; Novakovi? Svetlana

2005-01-01

352

Inflammatory cytokine detection in adenotonsill and peripheral blood mononuclear cells- culture in adenotonsillectomy patients: a comparative study  

Directory of Open Access Journals (Sweden)

Full Text Available Background: Tonsils and adenoid hypertrophy is a major respiratory symptom in children which is partly due to recruitment of inflammatory cells in upper airway lymph nodes as a result of the effects of synthesis and release of different inflammatory cytokines. It seems that infections play role in concert with these cytokines leading to tonsilar hypertrophy and other pathologic consequences. It is proposed that cellular infiltrate of tonsils and adenoids may secrete different quantities of these cytokines compared with peripheral blood mononuclear cells (PBMC) cultures.Methods: Among patients who were admitted for adenotonsillectomy to the ENT ward, 37 patients, under 1-12 years old patients with fulfill criteria selected to include the study. Excised adenoid and tonsils cultured and inflammatory cytokines Interferon-? (INF-?), Interlukine-1 (IL-1), IL-6, IL-8 and tumor necrosis factor-? (TNF-?) measured in cellular culture supernatant. The same cytokines measured in PBMC cultures.Results: The data shows that there is a significant difference between IFN-? and IL-8 amounts in adenoid tissue culture supernatant and PBMC culture of our patients. Furth-ermore, the amounts of IFN-?, IL-1 and IL-8 showed considerable difference between tonsilar tissue culture supernatant and PBMC culture of these patients. Although there is a significant correlation between IL-6 amounts in tissue culture supernatant and PBMC culture (P=0.02), the respective data for TNF is only almost significant.Conclusion: Inflammatory cytokines may have significant role in the early provoke of inflammation occurred in hypertrophied tonsils and adenoid. The majority of these cyt-okines increase the expression of adhesion molecules on epithelial cells and influence the recruitment of leucocytes and inflamed tonsils. On the other hand lack of sufficient cytokine release may lead to persistent infections and may cause chronic inflammation and hypertrophied tissue.

Farhadi M; Tabatabaei A; Shekarabi M; Noorbakhsh S; Shokrollahi MR; Javadi Nia Sh; Faramarzi M

2013-01-01

353

CT and MRI features of perineural tumor spreading along the trigeminal nerve in malignant head and neck tumors  

International Nuclear Information System (INIS)

Objective: To study the imaging features regarding perineural spread of tumor along the trigeminal nerve in malignant head and neck tumors, investigate its usefulness in improving diagnostic accuracy and palnning for clinical treatment. Methods: Images in 9 patients with clinical or radiological findings suggestive of perineural spread along trigeminal nerve were retrospectively studied. Results: Among the 9 patients, 6 were adenoid cystic carcinoma of the hard palate (n=3), maxillary sinus (n=1), parotid gland (n=1) and buccal space (n=1), respectively. Two were nasopharyngeal carcinoma and 1 was squamous carcinoma of the maxillary sinus. Enlargement and fat effacement of greater palatine foramen and pterygopalatine fossa distant from primary diseases were seen in all the 3 patients with adenoid cystic carcinoma of the hard palate and 1 with squamous carcinoma of maxillary sinus, furthermore, enlargement of foramen ovale and invasion of meckal cave was seen in 1 case. Erosion of infraorbital foramen and enlargement of the pterygopalatine fossa was seen in 1 patient with adenoid cystic carcinoma of maxillary sinus. Enlargement of pterygopalsatine fossa and foramen rotundum and invasion of the Meckal cave were seen in 1 patient with adenoid cystic carcinoma of buccal space. Perineural spread along auriculotemporal nerve and intracranial invasion through foramen ovale were seen in 1 patient with adenoid cystic carcinoma of parotid gland. Enhancement of mandibular nerve was seen in 2 patients with nasopharyngeal carcinoma. Conclusion: Perineural tumor spread along trigeminal nerve can be seen in malignant head and neck tumors, and knowledge of the anatomy of trigeminal nerve and its surrounding structures is important for correct diagnosis. (authors)

2005-01-01

354

Recurrent acute otitis media in infants: Analysis of risk factors.  

UK PubMed Central (United Kingdom)

OBJECTIVE: Recurrence acute otitis media (RAOM) may cause a considerable morbidity and a great parental concern. The aim of this study was to analyze the risk factors that are likely to be responsible for RAOM in infants, and their impact on treatment failure. METHODS: A retrospective study on 340 infants with RAOM was conducted. Data were collected from hospital charts. A 10 days course of amoxicillin/clavulanate was used for treatment of recurrence, while surgical management in the form of adenoidectomy and/or myringotomy was reserved for patients with persistent disease. We analyzed various risk factors that may affect the prognosis of RAOM, including: age, prematurity, upper respiratory tract infections (URTI), duration of breastfeeding, use of pacifiers, parental smoking, seasonality, the presence of siblings (family size), gender, adenoid hypertrophy, allergy, and craniofacial abnormalities. RESULTS: Use of pacifiers, short duration of breastfeeding, older infantile age, winter season, URTI and presence of adenoid hypertrophy were identified as risk factors for RAOM. Treatment failure may be due to adenoid hypertrophy, short duration of breastfeeding and it is more common in older age infants. We did not find a significant association between RAOM and gender, prematurity, exposure to passive smoking, the presence of siblings, allergy, craniofacial abnormalities. CONCLUSIONS: Factors that may cause recurrence of the disease in infant population are use of pacifiers, short duration of breastfeeding, older infantile age, winter season, upper respiratory tract infections and adenoid hypertrophy. Also, treatment failure may be caused by adenoid hypertrophy and short duration of breastfeeding. Good understanding of these factors may help to decrease the recurrence rate and to improve the treatment of the disease.

Salah M; Abdel-Aziz M; Al-Farok A; Jebrini A

2013-10-01

355

Autoradiographic studies and experiments on partical synchronization of human tumors, especially mammary carcinomas, in vitro and in vivo following xenotransplantation to NU/NU mice  

International Nuclear Information System (INIS)

[en] Human mammary carcinomes were evaluated radiographically in vitro in the native state. Penetration dephts up to 552 ?m into the tissue were reached by the incubating medium. The labelling indices for the 3H-thymidine autoradiography lay between 1.5 and 19.3 percent. A correlation of the autoradiographic labelling indices with the findings of a simultaneously performed in vitro sensitivity test against cytostalics could not be proved. There seems to be a relation between the histomorphological tumour image and the proliferation behaviour expressed by the autoradiographic labelling index. Human mammary carcinomes were cultivated as xeno-transplant on thymus-aplastic NU/NU mice in parallel to this investigation. These heterotransplants show a remarkable correlation to the proliferation behaviour of the directly examined human tumours, after an autoradiographic in-vivo-labelling, with index values between 1.5 and 23.8 percent. This parallelism in the biological behaviour represents a further proof for the usefulness of the oncological test model of the NU/NU mouse as a carrier for human cacinomes. The application of this pre-therapeutical test model followed by determination of the synchronization behaviour of three human malignomas after xeno-transplantation onto NU/NU mice. For all three tumous an individual synchronization behaviour could be determined. Therapy attempts followed with cyclophosphonide or ionizing radiation by using the optimal cell-cycle therapy. Therefore an improvement of the therapeutical success by means of pre-therapeutical synchronization of human tumours can be reached in particular cases. (orig./MG)

1980-01-01

356

Tumor adenomatoide del aparato genital. Estudio clinico-patológico e inmunohistoquímico de 9 casos/ Adenomatoid tumor of the genital tract. Clinical, pathological and immunohistochemical study in 9 cases  

Scientific Electronic Library Online (English)

Full Text Available Abstract in spanish Objetivo: Estudio clinico-patológico e inmunohistoquímico de tumores adenomatoides del aparato genital. Material y métodos: Se describen las características histológicas e inmunohistoquímicas de nueve tumores adenomatoides del Centro Médico ABC diagnosticados entre enero del 2000 a mayo del 2004. Resultados: Ocho mujeres y un hombre. Las edades variaron entre 28 y 54 años de edad. Los tumores se localizaron en útero (siete), salpinge (uno) y epidídimo (uno). El (more) tamaño de los tumores varió entre 0.4 y 5.8cm. Se encontraron tres patrones histológicos: adenoide, angiomatoide y sólido. Características histológicas peculiares fueron la disposición de los túbulos neoplásicos alrededor de los fascículos de músculo liso y la localización periférica del patrón angiomatoide y central de los patrones sólido y adenoide en el tumor. Inmunohistoquímicamente todos los tumores mostraron positividad intensa y difusa para calretinina y AE1/AE3. La trombomodulina fue positiva en todos los tumores (focal y débil en el patrón angiomatoide y difusa e intensa en los patrones adenoide y sólido). La CK5/6 fue positiva en siete tumores (difusa en tres y focal en cuatro). Dos tumores fueron negativos para este marcador. Todos los tumores fueron negativos para CD31. Conclusiones: El inmunofenotipo expresado en nuestros casos confirma el origen mesotelial de los tumores adenomatoides. Abstract in english Objetive: Describe the histological and immunohistochemical features of nine genital tract adenomatoid tumors . Material and methods: Nine cases of adenomatoid tumors were collected from the files of the Pathology department at a private hospital (ABC Hospital). Tumors were studied from a histological and inmunohistochemical perspective. Results: Eight women and one man were studied. Age range was 28-54 yrs. Tumors were located in the uterus (seven), fallopian tube (one) (more) and epididymis (one). Tumor size ranged from 0.4 to 5.8 cm. We observed three histological patterns: adenoid, angiomatoid and solid. Arrangement of the neoplastic tubules around fascicles of smooth muscle; angiomatoid pattern with a peripheral location, and solid and adenoid patterns with a central location in the tumor were some of the observed histological features. Immunohistochemically all tumors exhibited strong and diffuse positivity for calretinin and AE1/AE3. Thrombomodulin was positive in all tumors (focal and weak in angiomatoid pattern and diffuse and strong in adenoid and solid patterns). The CK5/6 antibody was positive in seven tumors (diffuse in three and focal in four). Two tumors were negative for this marker. All tumors were negative for CD31. Conclusions: The immunophenotype of the adenomatoid tumors in our series confirms their mesothelial origin.

Canedo-Patzi, Ana Marcela; de León-Bojorge, Beatriz; Ortíz-Hidalgo, Carlos

2006-02-01

357

Life threatening medullary injury following adenoidectomy and local anesthetic infiltration of the operative bed.  

UK PubMed Central (United Kingdom)

OBJECTIVE: To draw attention to a rare, life threatening complication of a rather common procedure, namely medullary injury following adenoidectomy and local anesthetic infiltration of the operative bed. DESIGN: Case report. SETTING: A tertiary pediatric critical care unit. PATIENT: A healthy 7-year-old girl underwent adenoidectomy and local anesthetic infiltration of the adenoid bed with lidocaine and adrenaline. In the recovery room, nystagmus, dysarthria, dyspnea, inability to cough and right hemiparesis were noticed. Because of her inability to remove secretions tracheal intubation was performed, followed by severe, life threatening respiratory failure. INTERVENTIONS: Tracheal intubation, hemodynamic support, prolonged mechanical ventilation, nitric oxide, and tracheostomy. CONCLUSION: In children, local anesthetic infiltration of the adenoid bed may cause life-threatening medullary injury and its routine use should be re-considered.

Hershman E; Halberthal M; Goldsher D; Golz A; Bar-Joseph G

2009-02-01

358

Beta-lactamase-producing bacteria in head and neck infection.  

UK PubMed Central (United Kingdom)

We have summarized our experience in recovery of beta-lactamase-producing bacteria (BLPB) in head and neck infection (HNI). These HNI include conjunctivitis, serous and chronic otitis media, cholesteatoma, chronic mastoiditis, chronic sinusitis, adenoiditis, recurrent tonsillitis in children and adults, peritonsillar abscess, and retropharyngeal abscess. Beta-lactamase-producing bacteria were found in 262 (51%) of 513 patients with HNI; 72% had aerobic BLPB and 57% had anaerobic BLPB. The infections, where these organisms were most frequently recovered, were adenoiditis (85% of patients), tonsillitis in adults (82%) and children (74%), retropharyngeal abscess (71%), and chronic otitis media (57%). The predominant BLPB were Staphylococcus aureus (49% of patients with BLPB), the Bacteroides-melaninogenicus group (28%), the Bacteroides fragilis group (20%), Pseudomonas aeruginosa (13%), Hemophilus influenzae (5%), and Branhamella catarrhalis (3%). The high incidence of recovery of BLPB in head and neck infections may have important implications on the antimicrobial management of these infections.

Brook I

1988-04-01

359

Beta-lactamase-producing bacteria in head and neck infection.  

Science.gov (United States)

We have summarized our experience in recovery of beta-lactamase-producing bacteria (BLPB) in head and neck infection (HNI). These HNI include conjunctivitis, serous and chronic otitis media, cholesteatoma, chronic mastoiditis, chronic sinusitis, adenoiditis, recurrent tonsillitis in children and adults, peritonsillar abscess, and retropharyngeal abscess. Beta-lactamase-producing bacteria were found in 262 (51%) of 513 patients with HNI; 72% had aerobic BLPB and 57% had anaerobic BLPB. The infections, where these organisms were most frequently recovered, were adenoiditis (85% of patients), tonsillitis in adults (82%) and children (74%), retropharyngeal abscess (71%), and chronic otitis media (57%). The predominant BLPB were Staphylococcus aureus (49% of patients with BLPB), the Bacteroides-melaninogenicus group (28%), the Bacteroides fragilis group (20%), Pseudomonas aeruginosa (13%), Hemophilus influenzae (5%), and Branhamella catarrhalis (3%). The high incidence of recovery of BLPB in head and neck infections may have important implications on the antimicrobial management of these infections. PMID:3258396

Brook, I

1988-04-01

360

JCV/BKV and SV40 viral load in lymphoid tissues of young immunocompetent children from an area of north-east Italy.  

Science.gov (United States)

Polyomavirus infection occurring during childhood is followed by a lifelong latency in immunocompetent subjects. The major site of polyomavirus persistence are the uroepithelial cells which leads to oral transmission. It has recently been hypothesized that tonsils could be a possible reservoir. The role of tonsil, adenoid, and peripheral blood mononuclear cells (PBMCs) as possible sites of JCV, BKV, and SV40 latency in young healthy children was assessed. Two hundred fifteen fresh specimens, including 57 tonsil, 80 adenoid, and 78 PBMC samples from 80 immunocompetent children (mean age 4.8 years) were analyzed to determine the viral load by quantitative real-time PCR. The human herpes virus 6 (HHV-6) was tested as a lymphotropic reference virus. Polyomavirus was detected in 5/80 (6.2%) children while HHV-6 infection affected 27/80 children (33.7%) (P preferred site of polyomavirus latency, at least in younger children. PMID:20513090

Comar, Manola; Zanotta, Nunzia; Bovenzi, Massimo; Campello, Cesare

2010-07-01

 
 
 
 
361

Fine-needle aspiration cytology of basaloid squamous cell carcinoma and small cell carcinoma-a comparison study.  

UK PubMed Central (United Kingdom)

The cytopathologic diagnosis of basaloid squamous cell carcinoma can be problematic as there are several components of the differential diagnosis that share common cytomorphologic features. In this study, we report the fine-needle aspiration (FNA) findings of 16 basaloid squamous cell carcinoma cases and compare those cases to 16 cases of small cell carcinoma. To our knowledge, this is the largest series of basaloid squamous cell carcinoma FNA cases ever reported. The following cytomorphologic features were compared for both tumors: cohesive tissue fragments, single cells, adenoid cystic-like features (cribriform pseudoglandular lumina with hyaline materials), necrosis, nuclear size, nuclear molding, nucleoli, cytoplasm, and the presence of single keratinized cells. Adenoid cystic-like features and the presence of single keratinized cells were specific for basaloid squamous cell carcinoma (P < 0.05).

Marks RA; Cramer HM; Wu HH

2013-01-01

362

Otitis media con efusión: estudio de casos y controles Otitis media with effusion: study of cases and controls  

Directory of Open Access Journals (Sweden)

Full Text Available Se realizó un estudio en 66 niños y 34 niñas de 2 a 12 años. Cincuenta fueron casos de otitis media con efusión (OME) y 50 controles. El grupo etario más numeroso fue el de dos años. Los síntomas y signos más frecuentes fueron otalgia y fiebre (70%) e hipoacusia (40%). Veintinueve casos (58%) y sólo 12 controles (24%) presentaron adenoides hipertróficas (p Between July 1988 and May 1989 we studied 100 children aged2-14 years; there were fifty cases of otitis media with effusion (OME) and fifty controls. Each group Included 33 boys and 17 girls. The predominant age group was 2 years. The most frequent clinical manifestations of OME were earache and fever (70% each) and reduced hearing (40%). In 29 cases (58%) and in only 12 controls (24%) enlarged adenoids were found (p

Eduardo Henao; Fernando Montoya; Sonia Grisales; Teresa Restrepo

1992-01-01

363

Specific medical and surgical treatment for chronic inflammatory diseases in children.  

UK PubMed Central (United Kingdom)

Treatment for chronic inflammatory conditions in children should take into account the specific pathophysiological and clinical processes underlying these disorders. These guidelines provide a framework for both the medical and surgical treatment of chronic inflammatory diseases such as otitis media, allergic rhinitis and chronic rhinosinusitis, chronic inflammation of tonsils and adenoids, and laryngitis. In addition, the role of vaccinations and immunomodulatory therapies is discussed. Whenever possible, the evidence levels for specific treatments comply with the Oxford Levels of Evidence.

Boudewyns A; Antunes J; Bernheim N; Claes J; De Dooy J; De Leenheer E; De Roeck K; Hellings P; de Varebeke SJ; Jorissen M; Ketelslagers K; Lemkens N; Lemkens P; Leupe P; Malfroot A; Maris M; Michiels E; Van Crombrugge L; Vandenplas Y; Verhulst S; Eloy P; Watelet JB

2012-01-01

364

Specific medical and surgical treatment for chronic inflammatory diseases in children.  

Science.gov (United States)

Treatment for chronic inflammatory conditions in children should take into account the specific pathophysiological and clinical processes underlying these disorders. These guidelines provide a framework for both the medical and surgical treatment of chronic inflammatory diseases such as otitis media, allergic rhinitis and chronic rhinosinusitis, chronic inflammation of tonsils and adenoids, and laryngitis. In addition, the role of vaccinations and immunomodulatory therapies is discussed. Whenever possible, the evidence levels for specific treatments comply with the Oxford Levels of Evidence. PMID:23431617

Boudewyns, A; Antunes, J; Bernheim, N; Claes, J; De Dooy, J; De Leenheer, E; De Roeck, K; Hellings, P; de Varebeke, S Janssens; Jorissen, M; Ketelslagers, K; Lemkens, N; Lemkens, P; Leupe, P; Malfroot, A; Maris, M; Michiels, E; Van Crombrugge, L; Vandenplas, Y; Verhulst, S; Eloy, P; Watelet, J B

2012-01-01

365

A Survey on Dentofacia! Cephalometric Measurements in Mouth Breathing Patients with Nasopharyngeal Obstruction  

Directory of Open Access Journals (Sweden)

Full Text Available Statement of Problem: The significance of adenoid tissue in Orthodontia appeared in 1954. At that time,even as today, orthodontists had an enduring interest in the relationship between excessive amounts of adenoid tissue, the developing occlusion, and facial morphology.Purpose: The aim of this study was to evaluate effect of mouth breathing with adenoid enlargement ondentofacia! cephalometric measurements.Material and Methods: A sample of 92 subjects between the ages of 6 and 15 years old were studied in twostudy and control groups. In study group, 46 mouth breathers (32 girls and 14 boys) with mean of 1 1.26 yearsold were examined by orthodontist and ENT specialist in order to confirmation of nasopharyngeal obstruction.Control group contained 46 nasal breathers (35 girls and 11 boys) with mean of 11.33 years old. For eachpatient in centric occlusion, a lateral cephalogram was taken and traced. 12 dentofacial variables weremeasured and statistical t-test was conducted by calculating the mean, standard deviation and p-value ofparameters. Statistical t-test for mean oi~ dentofacial variables for the two groups revealed that some ofvariables were significantly different.Results: In study group Z Go.Me-SN, Z Y-A.xis, Z Go, Z SN-PL variables were significantly higher than control group and Z HoFIl, Z SNB were significantly lower. The other dentofacial variables (ZS, IMPA,Z SNA, Z ANB. Z Ar and LH) didn't show any significant difference.Conclusion: Adenoid enlargement and nasopharyngeal obstruction can affect dentofacial morphology and cause facial vertical growth pattern and upper centrals retrusion.

MM.Toodeh-Zaeim; H.Ravanmehr

2005-01-01

366

Histopathological study of lung cancer and other pulmonary malignant tumors in people exposed to the atomic bomb and non-exposed people in Hiroshima Pref  

Energy Technology Data Exchange (ETDEWEB)

During cancer is likely to be more prevalent among A-bomb survivors based on epidemiological statistics. The histopathological classification of lung cancer was studied in 238 cases (57 exposed and 181 non-exposed) with onset in a period 1973-1977. None of the exposed patients had carcinoid, adenoid cystic carcinoma or mucoepidermoid carcinoma probably originating in the bronchial gland. Most of the exposed patients were slightly older than the non-exposed. Adenocarcinoma was more frequent among the exposed.

Yamada, Akira (Hiroshima Prefecture (Japan))

1983-04-01

367

A histopathological study of lung cancer and other pulmonary malignant tumors in people exposed to the atomic bomb and non-exposed people in Hiroshima Pref  

International Nuclear Information System (INIS)

During cancer is likely to be more prevalent among A-bomb survivors based on epidemiological statistics. The histopathological classification of lung cancer was studied in 238 cases (57 exposed and 181 non-exposed) with onset in a period 1973 - 1977. None of the exposed patients had carcinoid, adenoid cystic carcinoma or mucoepidermoid carcinoma probably originating in the bronchial gland. Most of the exposed patients were slightly older than the non-exposed. Adenocarcinoma was more frequent among the exposed. (Chiba, N.)

1983-01-01

368

Carinal resection requiring cardiopulmonary bypass in a pregnant patient.  

UK PubMed Central (United Kingdom)

A 35-year-old woman at 13 weeks gestation presented with adenoid cystic carcinoma of the distal left mainstem bronchus with chronic collapse of the left lung requiring carinal pneumonectomy. The extent of the tumor and need for significant retraction during dissection and pneumonectomy resulted in the need for cardiopulmonary bypass. The patient underwent successful left carinal pneumonectomy and subsequently delivered a healthy baby.

Fitzsimons MG; Ng J; Wright C; Mathisen D; Vlahakes G; Albrecht M

2013-09-01

369

Carinal resection requiring cardiopulmonary bypass in a pregnant patient.  

Science.gov (United States)

A 35-year-old woman at 13 weeks gestation presented with adenoid cystic carcinoma of the distal left mainstem bronchus with chronic collapse of the left lung requiring carinal pneumonectomy. The extent of the tumor and need for significant retraction during dissection and pneumonectomy resulted in the need for cardiopulmonary bypass. The patient underwent successful left carinal pneumonectomy and subsequently delivered a healthy baby. PMID:23992710

Fitzsimons, Michael G; Ng, Joshua; Wright, Cameron; Mathisen, Douglas; Vlahakes, Gus; Albrecht, Meredith

2013-09-01

370

Intra-thoracic Parathyroid Adenomatosis: A Case Report.  

UK PubMed Central (United Kingdom)

Ectopic mediastinal parathyroid adenomas are rare, but can be life-threatening. Resection is indicated in those cases accompanied by hypercalcemia, especially in young patients. Although most mediastinal parathyroid adenomas can be removed by a cervical approach, a transthoracic approach is needed when the adenoid tissues are located deep within the thoracic cavity. We describe the case of a 37-year-old female who underwent excision of an intrathoracic ectopic parathyroid adenoma after parathyroidectomy four months earlier.

Kim WK; Kim DK; Choi SH; Kim HR; Kim YH; Park SI

2013-08-01

371

Intra-thoracic Parathyroid Adenomatosis: A Case Report.  

Science.gov (United States)

Ectopic mediastinal parathyroid adenomas are rare, but can be life-threatening. Resection is indicated in those cases accompanied by hypercalcemia, especially in young patients. Although most mediastinal parathyroid adenomas can be removed by a cervical approach, a transthoracic approach is needed when the adenoid tissues are located deep within the thoracic cavity. We describe the case of a 37-year-old female who underwent excision of an intrathoracic ectopic parathyroid adenoma after parathyroidectomy four months earlier. PMID:24003415

Kim, Wan Kee; Kim, Dong Kwan; Choi, Se Hoon; Kim, Hyeong Ryul; Kim, Yong Hee; Park, Seung-Il

2013-08-06

372

Effect of allergic rhinitis on the expression of human ?-defensin 2 in tonsils.  

UK PubMed Central (United Kingdom)

BACKGROUND: Human ?-defensins (HBDs) are a newly identified family of antimicrobial peptides that are expressed by epithelia on mucosal surfaces. Exposure of airway epithelial cells to TH2-type cytokines results in a significant decrease in the antimicrobial activity of the cells. OBJECTIVE: To investigate the effect of allergic rhinitis on the expression of HBD-2 in tonsils and adenoids. METHODS: Palatine tonsils and adenoids were obtained from 30 patients with no history of recurrent tonsillitis. The patients were divided into 2 groups: allergic rhinitis and nonallergic rhinitis groups. Real-time polymerase chain reaction analysis was used to measure messenger RNA (mRNA) levels of HBD-2 mRNA in tonsil and adenoid tissue samples from the 2 patient groups. Immunofluorescent staining and enzyme-linked immunosorbent assay (ELISA) were used to evaluate the expression of HBD-2 protein in tonsil and adenoid tissues. The concentration of the cytokines interleukin (IL) 4, IL-5, and interferon ? (IFN-?) in tissue homogenates was measured by ELISA. RESULTS: Immunofluorescent staining data demonstrated the expression of HBD-2 protein in the surface epithelia of tonsils, and a marked difference in the staining intensity was observed the between 2 groups. HBD-2 mRNA and protein levels in the tonsils were significantly lower in the allergic rhinitis group than that in the nonallergic rhinitis group (P = .03 and P = .04, respectively). IL-5 and IFN-? were not detected, and no significant difference was found in IL-4 concentrations in tonsil homogenates between the 2 groups. CONCLUSION: Allergic rhinitis suppresses HBD-2, an epithelial antimicrobial peptide, in the tonsils.

Choi IJ; Rhee CS; Lee CH; Kim DY

2013-03-01

373

Epithelial keratin and filaggrin expression in seborrheic keratosis: evaluation based on histopathological classification.  

UK PubMed Central (United Kingdom)

OBJECTIVES: Seborrheic keratosis (SK) is classified into six types: hyperkeratotic; acanthotic; irritated; clonal; reticulated; and adenoid. However, the origins of the respective types of SK remain unclear. METHODS: To clarify the histogenetic origins of SK, we performed immunohistochemical studies of keratin (K) and filaggrin expression, taking into account the histopathological classifications of SK. RESULTS: Hyperkeratotic SK mainly expressed K1, K10, and filaggrin. Acanthotic SK mainly expressed K14 with some K15. Irritated SK mainly expressed K14 and K17 in squamous eddies. Clonal SK, reticulated SK, and adenoid SK mainly expressed K14. The results show that hyperkeratotic SK differentiated towards squamoid terminal keratinization, whereas acanthotic, irritated, clonal, reticulated, and adenoid SK mainly differentiated towards basaloid undifferentiated cells. In addition, acanthotic SK differentiated towards the hair bulge, and irritated SK differentiated towards the follicular infrainfundibulum. CONCLUSIONS: Based on the patterns of keratin and filaggrin expression demonstrated by the histopathological types, SK demonstrated diverse differentiation towards epidermal keratinization, basaloid cells, the infrainfundibulum and hair follicle bulges, which suggests that SK is in an undifferentiated and hyperproliferative state with heterogeneous differentiation. The immunohistochemical method of investigating patterns of keratin expression is useful in the differential diagnosis of cutaneous epithelial tumors.

Yoshimi N; Imai Y; Kakuno A; Tsubura A; Yamanishi K; Kurokawa I

2013-06-01

374

Maspin and MCM2 immunoprofiling in salivary gland carcinomas  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background The pathogenesis of salivary gland carcinomas is very complex and prognostic markers are difficult to find in these carcinomas of which the different subtypes have varying malignant potential. The study was conducted to examine the cellular distribution of maspin and MCM2 in salivary gland carcinomas and their value to predict lymph node metastasis. Materials and methods Fifty three paraffin blocks of different lesions (15 muco-epidermoid carcinoma, 14 adenoid cystic carcinoma, 3 epi-myoepithelial carcinoma, 5 salivary duct carcinoma, 5 malignant pleomorphic adenoma, 6 polymorphous low grade adenocarcinoma and 5 acinic cell carcinoma) were prepared for immunohistochemical staining with maspin and MCM2 antibodies. ANOVA and Pearson correlation tests were used for the statistical analysis of the results. Results All salivary gland carcinomas express maspin and MCM2 with variable cellular localization. There was a significant difference in the expression of each antibody between mucoepidermoid carcinoma, adenoid cystic carcinoma and polymorphous low grade adenocarcinoma. No association was found between examined markers and lymph node metastasis. Conclusions Salivary gland carcinomas express maspin and MCM2 with variable levels and cellular localization, consisting important markers of biological behavior in these tumors. The level of MCM2 expression can be used in the differential diagnosis of adenoid cystic carcinoma and polymorphous low grade adenocarcinoma. Further study with large sample size is recommended to assess their value in prediction of lymph node metastasis.

Ghazy Shaimaa E; Helmy Iman M; Baghdadi Houry M

2011-01-01

375

Maspin and MCM2 immunoprofiling in salivary gland carcinomas.  

UK PubMed Central (United Kingdom)

BACKGROUND: The pathogenesis of salivary gland carcinomas is very complex and prognostic markers are difficult to find in these carcinomas of which the different subtypes have varying malignant potential. The study was conducted to examine the cellular distribution of maspin and MCM2 in salivary gland carcinomas and their value to predict lymph node metastasis. MATERIALS AND METHODS: Fifty three paraffin blocks of different lesions (15 muco-epidermoid carcinoma, 14 adenoid cystic carcinoma, 3 epi-myoepithelial carcinoma, 5 salivary duct carcinoma, 5 malignant pleomorphic adenoma, 6 polymorphous low grade adenocarcinoma and 5 acinic cell carcinoma) were prepared for immunohistochemical staining with maspin and MCM2 antibodies. ANOVA and Pearson correlation tests were used for the statistical analysis of the results. RESULTS: All salivary gland carcinomas express maspin and MCM2 with variable cellular localization. There was a significant difference in the expression of each antibody between mucoepidermoid carcinoma, adenoid cystic carcinoma and polymorphous low grade adenocarcinoma. No association was found between examined markers and lymph node metastasis. CONCLUSIONS: Salivary gland carcinomas express maspin and MCM2 with variable levels and cellular localization, consisting important markers of biological behavior in these tumors. The level of MCM2 expression can be used in the differential diagnosis of adenoid cystic carcinoma and polymorphous low grade adenocarcinoma. Further study with large sample size is recommended to assess their value in prediction of lymph node metastasis.

Ghazy SE; Helmy IM; Baghdadi HM

2011-01-01

376

Evaluation of hyperactivity, attention deficit, and impulsivity before and after adenoidectomy/adenotonsillectomy surgery.  

UK PubMed Central (United Kingdom)

OBJECTIVE: The objective of this study was to determine the severity of attention deficit, hyperactivity, and impulsivity symptoms in patients with obstructive airway problems scheduled to undergo adenoidectomy or adenotonsillectomy operation. The effects of the surgical treatment on these symptoms will also be investigated in a case-control design. METHODS: This prospective study included 63 patients (29 girls, 34 boys) who were operated on at the Department of Otorhinolaryngology, Dicle University Medical School, between January 2010 and May 2011 because of obstructive symptoms caused by adenoid or adenotonsillar hypertrophy. The age range of the patients was between 4 and 13 years. The control group consisted of 33 (17 girls, 16 boys) healthy children. RESULTS: Among the patients, 15 children underwent adenoidectomy because of adenoid hypertrophy; 13 patients had adenotonsillectomy because of adenotonsillar hypertrophy, and the remaining patients underwent adenotonsillectomy related with chronic or recurrent tonsillitis with adenoid hypertrophy. Based on the preoperative data, statistically significant difference was observed between the patient and control groups. The patients' attention deficit, hyperactivity, and impulsivity symptoms preoperatively and postoperatively have shown statistically significant differences. CONCLUSIONS: Attention deficit, hyperactivity, and impulsivity symptoms were common among the children who show signs of airway obstruction due to adenotonsillar hypertrophy. Adenoidectomy or adenotonsillectomy operations were both observed to be associated with improvement in these symptoms.

Ayral M; Baylan MY; Kinis V; Bez Y; Bakir S; Ozbay M; Yorgancilar E; Gun R; Topcu I

2013-05-01

377

[Bacterial biofilm identification in the rhinopharingeal mucosa of children with recurrent infection of the upper respiratory tract and otitis media  

UK PubMed Central (United Kingdom)

OBJECTIVE: The objective of the present study was to identify bacterial biofilms in tissue samples obtained from paediatric patients undergoing surgical treatment, for recurrent upper airway infections, frequently associated to effusive otitis media, unresponsive to repeated cycles of selective medical antibiotic and anti-inflammatory therapy and assay the ability of Haemophilus influenzae strains, most frequently identified in our cultural examinations, to grow as biofilm in vitro. METHODS: We examined 18 surgical specimens (18 adenoids) from the upper respiratory tract, obtained from 18 paediatric patients. Tissues were cultured using conventional methods and subjected to scanning electron microscopy for detection of biofilm. Haemophilus influenzae strains, were cultured on 96-sterile well polystyrene microtiter plates (CELLSTAR-greiner bio-one) and stained with 1% crystal violet to quantify biofilm production. RESULTS: Bacterial cocci attached to the tissue surface and organized in colonies, with a morphology consistent with bacterial coccoid biofilms, were observed in all adenoid (18/18) samples. Haemophilus influenzae isolates from 11/18 (61.1%) of our tissue samples scored a percentual transmittance (%Tbloc) > 50, identifying a high capacity to form biofilms (level 4). CONCLUSIONS: Bacterial biofilms identified in adenoid tissue of paediatric patients with recurrent upper airway inflammatory processes, associated to chronic effusive otitis media, may represent a bacterial "reservoir" responsible of the maintenance of chronic inflammatory mucosal reactions, resistant to selective antibiotic therapy and requiring surgical treatment.

Galli J; Calò L; Ardito F; Imperiali M; Passali GC; Carnevale N; Fadda G; Paludetti G

2008-01-01

378

Radiation therapy for carcinoma of the major salivary glands  

International Nuclear Information System (INIS)

From January 1967 through November 1991, a total of 135 patients with carcinoma of the major salivary glands (parotid: 95; submandibular: 39, sublingual: 1) were treated at our department. 40 patients had adenocarcinoma, 29 adenoid cystic carcinoma, 24 mucoepidermoid carcinoma and 16 squamous cell carcinoma. 100 patients were irradiated postoperatively and the remaining 35 were treated with radiation alone. Total radiation doses delivered were 50 Gy for the postoperative group and 50 to 66 Gy for the group receiving only radiation using a 60Co single portal with or without wedged paired or single electron portal boost. Actuarial five-year survivals after radiation therapy were 55% for the postoperative group and 26% for radiation only group (p=0.0004). The local control rates for the postoperative group were 83% for adenocarcinoma, 81% for adenoid cystic carcinoma, 83% for mucoepidermoid carcinoma and 62% for squamous cell carcinoma. Corresponding figures for the radiation only group were 40% for adenocarcinoma, 38% for adenoid cystic carcinoma and 33% for mucoepidermoid carcinoma. Conventional irradiation techniques continue to play an important role because they offer superior local control for postoperative patients with carcinoma of the major salivary glands. However, the local control rates for the radiation only group were only 30 to 40%, so that new irradiation modalities such as provided by a high LET machine are needed for these patients. (orig.)

1993-01-01

379

Radiation therapy for carcinoma of the major salivary glands  

Energy Technology Data Exchange (ETDEWEB)

From January 1967 through November 1991, a total of 135 patients with carcinoma of the major salivary glands (parotid: 95; submandibular: 39, sublingual: 1) were treated at our department. 40 patients had adenocarcinoma, 29 adenoid cystic carcinoma, 24 mucoepidermoid carcinoma and 16 squamous cell carcinoma. 100 patients were irradiated postoperatively and the remaining 35 were treated with radiation alone. Total radiation doses delivered were 50 Gy for the postoperative group and 50 to 66 Gy for the group receiving only radiation using a [sup 60]Co single portal with or without wedged paired or single electron portal boost. Actuarial five-year survivals after radiation therapy were 55% for the postoperative group and 26% for radiation only group (p=0.0004). The local control rates for the postoperative group were 83% for adenocarcinoma, 81% for adenoid cystic carcinoma, 83% for mucoepidermoid carcinoma and 62% for squamous cell carcinoma. Corresponding figures for the radiation only group were 40% for adenocarcinoma, 38% for adenoid cystic carcinoma and 33% for mucoepidermoid carcinoma. Conventional irradiation techniques continue to play an important role because they offer superior local control for postoperative patients with carcinoma of the major salivary glands. However, the local control rates for the radiation only group were only 30 to 40%, so that new irradiation modalities such as provided by a high LET machine are needed for these patients. (orig.)

Teshima, T. (Dept. of Radiology, Osaka Univ. Medical School (Japan)); Inoue, Ta. (Dept. of Radiology, Osaka Univ. Medical School (Japan)); Inoue, To. (Dept. of Radiation Oncology, Osaka Univ. Medical School (Japan)); Ikeda, H. (Dept. of Radiation Oncology, Osaka Univ. Medical School (Japan)); Yamazaki, H. (Dept. of Radiation Oncology, Osaka Univ. Medical School (Japan)); Ohtani, M. (Dept. of Radiology, Osaka Univ. Medical School (Japan)); Shimizutani, K. (Dept. of Radiology, Osaka Univ. Medical School (Japan)); Furukawa, S. (Dept. of Radiology, Osaka Univ. Medical School (Japan)); Kozuka, T. (Dept. of Radiology, Osaka Univ. Medical School (Japan)); Murayama, S. (National Inst. of Radiological Science, Chiba (Japan))

1993-08-01

380

Otolaryngologic findings in prepubertal obese children with sleep-disordered breathing.  

UK PubMed Central (United Kingdom)

OBJECTIVE: To evaluate otolaryngologic findings in obese prepubertal children with sleep-disordered breathing. METHODS: We prospectively evaluated 29 obese children referred by pediatric endocrinologist, complainin