WorldWideScience

Sample records for carcinome adenoide kystique

  1. Adenoid cystic carcinoma of the head and neck; Les carcinomes adenoides kystiques de la tete et du cou

    Haddad, H.; Riahi, H.; Chekrine, T.; Benchakroun, N.; Jouhadi, H.; Tawfiq, N.; Sahraoui, S.; Benider, A. [Centre d' oncologie Ibn-Rochd, Casablanca, (Morocco)

    2007-11-15

    The adenoid cystic carcinoma or cylindroma develop principally from salivary glands. It is the most frequently at the level of head and neck. The aim of this work is to analyse the therapy data and to determine the prognostic factors of adenoid cystic carcinomas through a retrospective study. (N.C.)

  2. Exclusive irradiation of cyst adenoid carcinomas: contribution of a dose complement in stereotactic mode; Irradiation exclusive des carcinomes adenoides kystiques: role d'un complement de dose en mode stereotaxique

    Coche-Dequeant, B.; Lefebvre, J.L.; Lacornerie, T.; Lartigau, E. [Centre Oscar-Lambret, 59 - Lille (France); Attar, M. [King Abdulaziz University Hospital, Jeddah, Arabie saoudite (Saudi Arabia)

    2009-10-15

    The cyst adenoid carcinoma is a rare malignant tumor that reaches principally the salivary glands; It is characterized by a clinical aggressiveness, the presence of peri neural invasions, frequent local recurrences and a high rate of metastases dissemination at delayed distance. The treatment is surgery with a postoperative adjuvant radiotherapy. for the patients suffering of inoperable tumors, the exclusive radiotherapy gives bad results with tests of use of heavy particles. The place of a hypo fractionated treatment on a stereotactic mode has not been evaluated, especially in dose complement after three dimensional irradiation. The purpose was to answer the following question if the Cyberknife was useful to deliver a complement of hypo fractionated stereotactic dose for the inoperable head and neck tumors. The limited number of patients does not allow a definitive conclusion. however, this therapy option seems interesting for the inoperable tumors subject to the management of the toxicity induced by the treatment. The evaluation of the irradiation volumes remains the critical element for the feasibility of this kind of protocol. (N.C.)

  3. Carcinome papillaire intra-kystique du sein: à propos de trois cas

    El Mazghi, Abderrahman; Bouhafa, Touria; Loukili, Kaoutar; El Kacemi, Hanan; Lalya, Issam; Kebdani, Taieb; Hassouni, Khalid

    2014-01-01

    Le Carcinome papillaire intra-kystique du sein est une entité très rare et représente 0,5 à 1% de l'ensemble des carcinomes mammaires. Il se caractérise généralement par une croissance lente avec un bon pronostic. Nous rapportons 03 nouveaux cas prouvés histologiquement, chez des patientes traitées par chirurgie radicale ou conservatrice, suivie d'une radiothérapie sur le sein en place et une hormonothérapie à base de tamoxifen chez les deux patientes avec des récepteurs hormonaux positifs. L...

  4. Literature review on the role of radiotherapy in the treatment of nasopharyngeal cystic adenoid carcinomas about two cases; Revue de la litterature sur la place de la radiotherapie dans le traitement des carcinomes adenoides kystiques du nasopharynx a propos de deux cas

    Hemmich, M.; Hassouni, K.; Elkacemi, H.; Errachdi, A.; Mouhajir, N.; Zaidi, H.; Benjaafar, N. [Institut national d' oncologie, Rabat (Morocco)

    2011-10-15

    The authors discuss the characteristics and the radiotherapy treatment procedures of cystic adenoid carcinomas, and more precisely the treatment of two of such cases of nasopharyngeal carcinomas. The first one had an incomplete resection surgery followed by curing radiotherapy: he has then been in local-regional control situation for 8 months. The second one had lung metastases, was treated chemotherapy and radiotherapy (decompressive treatment), and died six months after diagnosis. Radiotherapy is considered to be the treatment basis, whereas chemotherapy is a matter of controversy. Short communication

  5. Tonsils and Adenoids

    ... Blood tests - helpful in diagnosing infections such as mononucleosis Sleep study, or polysomnogram-helpful in determining whether ... adenoids. In some patients, especially those with infectious mononucleosis, severe enlargement may obstruct the airway. For those ...

  6. Carcinome hpatocellulaire non fibrolamellaire sur foie sain

    Bouomrani, Salem; Kilani, Ichrak; Nouma, Hanne; Slama, Alaeddine; Beji, Maher

    2014-01-01

    Le carcinome hpatocellulaire (CHC) survient le plus souvent sur foie de cirrhose. Sa survenue sur un foie sain est exceptionnelle et pose un vritable dfit diagnostique pour le clinicien. Nous rapportons l'observation d'un patient de 53 ans, sans antcdents pathologiques notables qui ft admis pour exploration d'une douleur de l'hypochondre droit voluant depuis quelques mois avec une exacerbation rcente, associe un amaigrissement important et une altration de ltat gnral. L'examen...

  7. Adenoid cystic carcinoma of larynx

    This case report presents the clinical picture, diagnostic methodology, and surgical treatment of a 30 years old female patient, who presented with hoarseness of voice and difficulty in breathing. Direct laryngoscopy showed mass in right side of subglottic region, and biopsy-proven adenoid cystic carcinoma. Total laryngectomy was performed and patient was discharged three weeks postoperatively and doing well. (author)

  8. ADENOIDS IN ADULT SIBLINGS : IS IT FAMILIAL ?

    Naik, Sulabha M.; Naik, Mahendra S.; Ginni Datta; Chandraprakash Sharma; Dalbir Singh

    2012-01-01

    Waldeyer’s ring is a collection of lymphoid tissue at the entrance to the aerodigestive tract.Adenoids are present in the nasopharyx.They begin to regress from the age of 8 to 10 years and nearly always disappear by adulthood.The persistent presence of adenoid tissue after puberty has been reported in literature.While investigating a case of nasal obstruction in adults,the possibility of persistence of adenoid tissue should be borne in mind.

  9. Adenoid Hypertrophy in Adults: A case Series

    Rout, Manas Ranjan; Mohanty, Diganta; Y Vijaylaxmi; Bobba, Kamlesh; Metta, Chakradhar

    2012-01-01

    Adenoid hypertrophy is common in children. Size of the adenoid increases up to the age of 6 years, then slowly atrophies and completely disappears at the age of 16 years. Adenoid hypertrophy in adults is rare. Present study shows that adenoid hypertrophy is now increasing in adults because of various causes. Study has been conducted in the Department of ENT and Head & Neck Surgery, Alluri Sitarama Raju Academy of Medical science, Eluru, Andhra Pradesh, India. Study shows that incidence of ade...

  10. Adenoidal size in lateral roentgenogram of skull

    Adenoid is a kind of tonsil located in the posterior wall of the nasopharynx. Enlargement of the adenoid can produce obstruction of the nasopharynx and eustachian tube. Disturbance in discharge of nasal and paranasal secretions can be a cause of chronic rhinitis, sinusitis and otitis media. The diagnosis of enlarged adenoid by inspection is difficult due to its location. In the lateral roentgenogram of the skull the anterior wall of the adenoid is sharply delineated by air in the nasopharynx. The authors measured the sizes of adenoid and nasopharynx and calculated the adenoid-nasopharyngeal ratio (AN ratio) from 1,000 simple skull lateral roentgenograms of the children between the age of 0 to 16 years. Adenoid size is gradually increasing in the children up to 9 years of age but almost uncharged in the older age group. The AN ratio is highest in the age group of 8-9 years. In the age groups above 9 years of age the AN ratio is gradually decreased due to atrophic changes of the adenoid

  11. Adenoid cystic carcinoma of the nasopharynx after previous adenoid irradiation

    Sofferman, R.A.; Heisse, J.W. Jr.

    1985-04-01

    In 1978, Pratt challenged the otolaryngology community to identify an incidence of malignancy in individuals who have previously received radium therapy to the nasopharyngeal lymphoid tissues. This case report is a direct response to that quest and presents a well documented adenoid cystic carcinoma evolving 23 years after radium applicator treatment to the fossa of Rosenmuller. Although a cause-and-effect relationship cannot be scientifically proven, the case history raises several important questions concerning the stimulating effects of radiation on the later onset of frank malignancy.

  12. Adenoid cystic carcinoma of the nasopharynx after previous adenoid irradiation

    In 1978, Pratt challenged the otolaryngology community to identify an incidence of malignancy in individuals who have previously received radium therapy to the nasopharyngeal lymphoid tissues. This case report is a direct response to that quest and presents a well documented adenoid cystic carcinoma evolving 23 years after radium applicator treatment to the fossa of Rosenmuller. Although a cause-and-effect relationship cannot be scientifically proven, the case history raises several important questions concerning the stimulating effects of radiation on the later onset of frank malignancy

  13. Adenoid cystic carcinoma of the lacrimal gland

    von Holstein, Sarah L; Fehr, André; Persson, Marta; Therkildsen, Marianne H; Prause, Jan Ulrik; Heegaard, Steffen; Stenman, Göran

    2013-01-01

    To investigate genetic alterations in lacrimal gland adenoid cystic carcinomas (ACCs) with emphasis on the MYB-NFIB fusion oncogene and its downstream targets, MYB rearrangements, and copy number alterations in relation to clinical data and survival.......To investigate genetic alterations in lacrimal gland adenoid cystic carcinomas (ACCs) with emphasis on the MYB-NFIB fusion oncogene and its downstream targets, MYB rearrangements, and copy number alterations in relation to clinical data and survival....

  14. Phototherapy of adenoid disease in children

    Naumov, Sergey A.; Chankov, Ivan I.; Volovodenko, Alexey V.; Khlusov, Igor A.; Vovk, Sergey M.; Tuchin, Valery V.

    2004-08-01

    The results presented testify to the high clinical effectiveness of therapy of adenoid disease based on photodynamic effects caused by combined action of physical (red light) and chemical factors (methylene blue) on pathogenic microorganisms. Original physiotherapy device and autonomous photostimulator of "Duny" Inc. were used. Clinical results have a good correlation with results of bacteriological and cell research conducted in vivo and in vitro.

  15. Assessment of nasopharyngeal airway and adenoid by MRI

    Adenoid is a kind of tonsil located in the posterior wall of nasopharynx. Enlargement of the adenoid can produce obstruction of the nasopharynx and Eustachian tube. Disturbance in discharge of nasal and paranasal secretions can be a cause of chronic rhinitis, sinusitis, and otitis media. Diagnosis of enlarged adenoid simply by inspection is different due to its location. Measurement of nasopharyngeal airway and adenoid using lateral radiographs of nasopharynx may be inaccurate for magnification and rotation. It was some limitations in demonstrating the actual state of nasopharyngeal airway and adenoid because it gives only two dimensional information. The authors measured the size and areas of nasopharyngeal airway and adenoid using MRI with sagittal and oblique coronal pilot views of T1 weighted spin echo. We categorized the patients into 4 groups according to the scoring system by symptoms such as apnea, mouth breathing, and snoring. The results of several measurment and their ratios were evaluated in these 4 categorized patients. The ratios of area of adenoid and nasopharyngeal airway (AA/Na) in each patient group were 6.52, 7.76, 10.53, 15.93, respectively. And the ratios of adenoid and nasopharyngeal airway (A/N) by Fujioka's method were 0.6, 0.65, 0.69, 0.71, respectively. We found that AA/Na might be the most effective index as an objective indicator in the evaluation of nasopharyngeal obstruction by the enlarged adenoid

  16. Carcinome collode du sein: propos d'un cas

    Laabadi, Kamilia; Jayi, Sofia; Alaoui, Fatimazohra Fdili; Bouguern, Hakima; Chaara, Hikmat; Melhouf, My Abdelilah

    2013-01-01

    Nous rapportons le cas d'une tumeur collode du sein chez un homme. Cette situation rare interpelle par son mode de dcouverte. Nous avons pris en charge un homme de 60 ans atteint d'une lsion rtro-arolaire droite classe cliniquement T4b N1 M0 et suspecte radiologiquement. L'analyse histologique (microbiopsie) a conclu un carcinome collode muqueux associ une petite composante canalaire classique de grade I de SBR du sein. Les traitements complmentaires associent mastectomie, curage, chimiothrapie, radiothrapie et hormonothrapie. Le cancer du sein est rare chez l'homme. Le carcinome collode est exceptionnel puisqu'il reprsente seulement 1 6% de l'ensemble des cancers du sein. Il est encore plus rare chez l'homme. Ces tumeurs touchent une population spcifique et ont un meilleur pronostic que les autres types prpondrant dans les cancers du sein chez l'homme. A travers cette observation et une revue de la littrature, nous essaierons de discuter les principales caractristiques anatomo-cliniques et volutives de cette forme rare du cancer du sein. PMID:24772222

  17. Adenoid hypertrophy presenting with systemic hypertension

    Subashini, P.; A. Ravikumar; Ranjit, M S; Sairam, V. K.; Vatsanath, R. P.; Jayasree, S.

    2007-01-01

    A two and half year old male child was seen with systemic hypertension, left ventricular dysfunction, mitral regurgitation and congestive cardiac failure. Examination revealed adenoid hypertrophy. He was also suffering from obstructive sleep apnea. He was being treated with anti-hypertensive and anti-failure drugs. Adenoidectomy was performed following which obstructive sleep apnea symptoms disappeared and his cardiac status improved markedly. Subsequently he was weaned off anti-hypertensive ...

  18. Paediatric refractory rhinosinusitis secondary to hypertrophied adenoids: management and review of literature.

    Gautham MK

    2014-06-01

    Full Text Available Background /Objectives: Hypertrophied adenoids are the most common cause of refractory sinusitis in paediatric age. We study 42 cases of patients of chronic adenoiditis with adenoid facies and refractory chronic rhinosinusitis managed by endoscopic assisted adenoidectomy (EAA and conventional adenoidectomy (CA. Materials and method: 42 cases of chronic refractory sinusitis with adenoid facies secondary to hypertrophied adenoids were randomized into 2 groups during the study period of 12 months from August 2012 to July 2013. Group A (n=21 underwent endoscope assisted adenoidectomy and Group B(n=21 underwent conventional adenoidectomy. Result: Endoscopic assisted adenoidectomy proves to be more effective in managing adenoid facies and chronic refractory rhinosinusitis with adenoid hyperplasia. Conclusion: Visualization of the adenoid mass using endoscope helps complete removal of the diseased adenoids. Endoscopic assisted adenoidectomy is treatment of choice in adenoid facies and chronic refractory rhinosinusitis with adenoid hyperplasia and more effective than conventional adenoidectomy.

  19. Salivary adenoid cystic carcinoma in Denmark 1990-2005

    Bjørndal, Kristine; Krogdahl, Annelise; Therkildsen, Marianne H; Charabi, Birgitte; Kristensen, Claus A; Andersen, Elo; Schytte, Sten; Primdahl, Hanne; Johansen, Jørgen; Pedersen, Henrik B; Andersen, Lisbeth J; Godballe, Christian

    2015-01-01

    AIM: To describe outcome and prognostic factors, including the effect of radiotherapy, in a consecutive national series of salivary gland adenoid cystic carcinomas. METHODS: From the national Danish salivary gland carcinoma database in the structure of DAHANCA, 201 patients diagnosed with adenoid...

  20. Adenoid facies and chronic refractory rhinosinusitis managed by endoscopic-assisted adenoidectomy

    Sudhir M Naik

    2015-12-01

    Full Text Available Background /Objectives: To study 30 cases of patients of chronic adenoiditis with adenoid facies and refractory chronic rhinosinusitis managed by endoscopic assisted adenoidectomy. Materials and method: 7 cases of adenoid facies and 23 cases of chronic refractory rhinosinusitis with adenoiditis were managed by endoscopic assisted adenoidectomy during the study period of 12 months from August 2012 to July 2013. Result: endoscopic assisted adenoidectomy proves to be more effective in managing adenoid facies and chronic refractory rhinosinusitis with adenoid hyperplasia. Conclusion: visualization of the adenoid mass using endoscope helps complete removal of the diseased adenoids. Endoscopic assisted adenoidectomy is treatment of choice in adenoid facies and chronic refractory rhinosinusitis with adenoid hyperplasia and more effective than conventional adenoidectomy.

  1. Paediatric refractory rhinosinusitis secondary to hypertrophied adenoids: management and review of literature.

    MK Gautham; Ravishankara S; Naik, Sudhir M.; Sathya P; Mohan Appaji; Shankarnarayan Bhat; Ravi Karumbiah

    2014-01-01

    Background /Objectives: Hypertrophied adenoids are the most common cause of refractory sinusitis in paediatric age. We study 42 cases of patients of chronic adenoiditis with adenoid facies and refractory chronic rhinosinusitis managed by endoscopic assisted adenoidectomy (EAA) and conventional adenoidectomy (CA). Materials and method: 42 cases of chronic refractory sinusitis with adenoid facies secondary to hypertrophied adenoids were randomized into 2 groups during the study p...

  2. The adenoid-nasopharynx ratio. Its clinical value in children

    To evaluate the clinical usefulness of adenoid-nasopharynx ratio (A/N ratio) measured on nasopharyngeal lateral plain film, 106 clinical cases of secretory otitis media were selected to measure the A/N ratio before treatment. For patients with A/N ratio of 0.50-0.70, the symptoms improved distinctly after conservative treatment, but one half of patients with A/N ratio ? 0.71 required adenoidectomy. A/N ratio is a practical and convenient method for evaluation of the adenoid. A/N ratio ? 0.71 indicates pathological enlarged adenoid

  3. [Risk factors to develop adenoid vegetations in children].

    Borzov, E V

    2003-01-01

    To evaluate perinatal factors of risk to develop adenoid vegetations in childhood, 600 children were examined. Their perinatal period and health in the first year of life were investigated. 400 examinees aged 2-12 years had adenoids of the second-third degree. 200 children aged 13-14 had no history of the lymphadenoid pharyngeal ring. The degree of the studied factors impact on development of pharyngeal tonsil affection was estimated using the unifactor dispersion analysis. Correlation was found between some complications of pregnancy and labour, health problems at birth and first year of life and development of adenoid vegetations. PMID:12958856

  4. Carcinome basocellulaire de la face: à propos de quatre cas rapportés à Madagascar

    Razafindrakoto, Rex Mario; Razafindranaivo, Mananjara Nandrianina; Schammirah, Mahamad Rojovolaarivony; Randriamboavonjy, Rado

    2015-01-01

    Les carcinomes basocellulaires, fréquemment rencontrés dans la race blanche, sont plus rares chez les sujets de race noire. Les zones exposées de la tête sont des sites préférentiels, et une intense exposition aux rayons solaires ultraviolets a été évoquée dans leur étiopathogénie. Les métastases sont exceptionnelles. Les objectifs ont été de démontrer l'existence de carcinomes basocellulaires à Madagascar et d'en évaluer la prise en charge. Les auteurs ont rapporté quatre cas de carcinomes b...

  5. Les carcinomes de la thyrode: profils pidmiologique, clinique et thrapeutique, propos de 102 cas

    Touati, Mohamed Mliha; Aljalil, Abdelfettah; Darouassi, Youssef; Chihani, Mehdi; Lahkim, Mohammed; Fihri, Jawad Al Fassi; Bouaity, Brahim; Ammar, Haddou

    2015-01-01

    Les carcinomes thyrodiens sont des tumeurs malignes assez rares, reprsentant 1% des cancers. Ils sont gnralement de bon pronostic, et prsentent des aspects cliniques et volutifs varis selon leur origine histologique. Notre travail est une tude rtrospective portant sur 102 cas de carcinomes de la thyrode, colligs sur un nombre total de 811 gestes chirurgicaux thyrodiens, au service d'oto-rhino-laryngologie et de chirurgie cervico-faciale de l'hpital militaire Avicenne de Marrakech, sur une priode de 8 ans, allant de janvier 2006 dcembre 2013. Les carcinomes thyrodiens atteignent le sujet jeune avant lge de 50 ans, en particulier le sexe fminin. La tendance dans les pays en voie de dveloppement, comme dans le monde entier est en croissance continue, ceci peut tre expliqu par l'amlioration des outils d'imagerie et des moyens diagnostiques cytologiques et anatomo-pathologiques. PMID:26405495

  6. Mitochondrial Mutations in Adenoid Cystic Carcinoma of the Salivary Glands

    Mithani, Suhail K.; Shao, Chunbo; Tan, Marietta; Smith, Ian M.; Califano, Joseph A.; El-Naggar, Adel K; Patrick K. Ha

    2009-01-01

    Background The MitoChip v2.0 resequencing array is an array-based technique allowing for accurate and complete sequencing of the mitochondrial genome. No studies have investigated mitochondrial mutation in salivary gland adenoid cystic carcinomas. Methodology The entire mitochondrial genome of 22 salivary gland adenoid cystic carcinomas (ACC) of salivary glands and matched leukocyte DNA was sequenced to determine the frequency and distribution of mitochondrial mutations in ACC tumors. Princip...

  7. Postoperative radiation therapy for adenoid cystic carcinoma

    The authors retrospectively assessed the usefulness of postoperative radiation therapy after local resection of adenoid cystic carcinoma, with emphasis on organ-conserving treatment and the cosmetic results. Between 1985 and 1995, 32 patients underwent local resection followed by postoperative radiation therapy with curative and organ-conserving intent. None of patients received any form of chemotherapy as part of their initial treatment. Radiation therapy was carried out by techniques that were appropriate for the site and extension of each tumor. The 5-year local control, disease-free, and overall survival rates of all patients were 76%, 68%, and 86%, respectively. The 5-year local control rate and disease-free survival rate of patients with microscopically positive margins were 89% and 75%, respectively, and higher than in patients with macroscopically residual disease, but no significant difference in 5-year overall survival rate was observed. The postoperative cosmetic results in 29 patients with head and neck lesions were evaluated. No difference was documented between the cosmetic results postoperatively setting and after postoperative radiotherapy, and no significant differences in cosmetic results were observed according to radiation dose. The combination of local resection with organ-conserving intent and postoperative radiation therapy provided good cosmetic results in patients with T1 or T2 lesions. Postoperative radiation therapy with smaller fractions is useful, because good local control can be achieved in patients with adenoid cystic carcinoma having microscopically positive margins without inducing any late adverse reactions. However, the number of patients was too small and the follow-up period was too short to draw any definite conclusion in regard to fraction size. A much longer follow-up study with a larger number patients will be required to accurately determine the optimal treatment intensity and duration of treatment. (K.H.)

  8. Carcinome basocellulaire de la face: à propos de quatre cas rapportés à Madagascar

    Razafindrakoto, Rex Mario; Razafindranaivo, Mananjara Nandrianina; Schammirah, Mahamad Rojovolaarivony; Randriamboavonjy, Rado

    2015-01-01

    Les carcinomes basocellulaires, fréquemment rencontrés dans la race blanche, sont plus rares chez les sujets de race noire. Les zones exposées de la tête sont des sites préférentiels, et une intense exposition aux rayons solaires ultraviolets a été évoquée dans leur étiopathogénie. Les métastases sont exceptionnelles. Les objectifs ont été de démontrer l'existence de carcinomes basocellulaires à Madagascar et d'en évaluer la prise en charge. Les auteurs ont rapporté quatre cas de carcinomes basocellulaires faciaux vus au service d'Oto-rhino-laryngologie du Centre Hospitalier Universitaire d'Antananarivo, avec deux hommes et deux femmes, âgés entre 46 et 70 ans (âge moyen= 53,5 ans). Une exérèse chirurgicale a été pratiquée chez trois patients tandis qu'un patient albinos a été traité par radiothérapie. L’épidémiologie, l’étiologie, l'anatomie pathologique et le traitement des carcinomes basocellulaires de la face ont été discutées à travers une revue de la littérature. PMID:26848344

  9. Asynchronous adenoid cystic carcinoma of the urinary bladder

    Histologic variants of prostatic carcinoma are readily reorganized. In this report, we describe a rare variant, adenoid cystic carcinoma in a 75-year-old man previously diagnosed to have transitional cell carcinoma of the urinary bladder. The diagnosis of adenoid cystic carcinoma was made by the characteristic microscopic features of the tumor morpholologically and immunohistochemically. Two months later he was found to have metastatic disease. The patient's treatment consisted of chemotherapy in combination with prednisone and hormonal therapy. Five and half months after diagnosis, he died with metastatic disease. Making this case unique is the asynchronous occurrence of this variant with transitional cell carcinoma of the urinary bladder, which has never be reported in the literature. We discussed the histopathologic and immunohistochemical features of adenoid cystic carcinoma of the prostate with review of literature. (author)

  10. A RARE CASE OF ADENOID CYSTIC CARCINOMA OF ETHMOID SINUS

    Bharath

    2013-02-01

    Full Text Available ABSTRACT: Adenoid cystic carcinoma is more common in minor sa livary glands, uncommon in parotid gland and rare in paranasal sinuses. These ar e more aggressive and fatal. Such tumors of the accessory nasal sinuses causing proptosis have be en reported so rarely in ophthalmic literature. An adult aged 31 years presented with pro ptosis of right eye, nasal obstruction and bleeding from right nose. CT scan showed soft tissu e attenuation mass with destruction of bony structures and extension to right orbit. Biopsy was done through trans nasal route. A histological diagnosis of Adenoid cystic carcinoma of ethmoid sinus was made

  11. Mandibular ameloblastoma and maxillary adenoid cystic carcinoma: case report.

    Tamme, Tiia; Leibur, Edvitar; Kulla, Andres

    2003-12-01

    We report the case of a 74-year-old woman who developed a follicular ameloblastoma of the right mandible and 22 months later developed a cribriform adenoid cystic carcinoma of the soft palate on the right maxilla. The ameloblastoma was treated by hemimandibulectomy, and the adenoid cystic carcinoma was managed by resection of the soft palate and the surrounding tissue and bone followed by a 6-week course of radiotherapy. Our review of the literature indicates that only one similar case has been previously reported where an odontogenic tumor and a salivary gland tumor involved two different anatomic locations in the same patient at nearly the same time. PMID:14702876

  12. Radiographic evaluation of adenoidal size in children: methods of measurement and parameters of normality; Avaliacao radiografica da adenoide em criancas: metodos de mensuracao e parametros da normalidade

    Araujo Neto, Severino Aires de [Centro de Assistencia Integral a Saude da Mulher (CAISM), Campinas, SP (Brazil)]. E-mail: severinoaires@hotmail.com; Queiroz, Suelio Marinho de [Tomovale, Sao Jose dos Campos, SP (Brazil); Baracat, Emilio Carlos Elias [Universidade Estadual de Campinas, SP (Brazil). Faculdade de Ciencias Medicas. Dept. de Pediatria; Pereira, Ines Minniti Rodrigues [Universidade Estadual de Campinas, SP (Brazil). Faculdade de Ciencias Medicas. Dept. de Radiologia

    2004-12-01

    Radiograph of the nasopharynx is still the most commonly used imaging method to investigate the adenoidal tissue. Due to the variety and complexity of proposed methods to measure the adenoid size, some radiologists prefer subjective evaluation, which can, however, be imprecise and inaccurate. We review and describe several methods to determine the adenoid size, taking into account the practicity, accuracy and precision with the aim of pointing out the best methods to be applied in daily routine practice. (author)

  13. Clinical analysis on nasopharyngeal adenoid cystic carcinoma

    Objective: To investigate the clinical features, treatment outcome and prognosis of patients with nasopharyngeal adenoid cystic carcinoma(ACC). Methods: From March 1963 to August 2002, 33 patients with ACC were retrospectively reviewed. Among them, 13 received multimodality therapy (S + R in 9 and R + S in 4) and the remaining 20 received radiotherapy alone. The interval between the first visit and clinical diagnosis was 12 months (1.0-36.4 months). The misdiagnosis rate was 55% (18/33 ), with the most common error of otitis media. The clinical symptoms of ACC were similar to those of squamous carcinoma in nasopharynx, though the cervical lymph node metastasis was rare (12%) and cranial nerve invasion was common (58%). Results: After a median follow-up of 60.8 months (5.0-245.2 months), the 5- and 10-year overall survival rates, free-disease survival rates, local regional control rates and metastasis-free survival rates were 66% and 29%, 41% and 27%, 61% and 40%, 62% and 62%, respectively. Among the 20 patients (61%) with recurrence, 15 had local regional failure (13 in situ and 2 in cervical lymph node), and 9 had distant metastasis (5 in the lung, 2 in the lung and bone, 1 in the liver and 1 in the bone). Univariate analysis showed that clinical stage was a prognostic factor (I + II vs III + IV, P=0.009), while treatment modality(radiotherapy alone vs multimodality therapy) was not. Conclusions: Nasopharyngeal ACC is a locally aggressive disease with a long course. Either radiotherapy alone or multimodality therapy( S + R/R + S) is effective in the treatment. (authors)

  14. Diagnosis and Treatment of Tracheal or Bronchuotracheal Adenoid Cystic Carcinoma

    Ming QIN

    2010-06-01

    Full Text Available Background and objective Adenoid cystic carcinoma is primary bronchopulmonary carcinoma with low malignancy, and 43 patients treated in the past 50 years in our hospital were retrospectively studied. The aim of this study is to discuss the clinical symptoms, pathologic characteristic and therapeutic method of primary tracheal or bronchuotracheal adenoid cystic carcinoma. Methods This study summarized total 43 patients of primary tracheal or bronchus adenoid cystic carcinoma treated in our hospital from Jan. 1958 to Dec. 2007. Among them, 40 patients were treated by surgical resection, and 3 patients were treated by fiberoptic bronchoscopes interventional treatment. Results The 1-yr, 3-yr, 5-yr survival rates of the 43 patients above were 100% (41/41, 89.5% (34/38, 87.1% (27/31, respectively. Conclusion Primary tracheal or bronchus adenoid cystic carcinoma are rare and low malignancy carcinoma. The clinical symptoms of them are not typical. The best treatment is early detection and taking measures of operation plus radiotherapy. The other palliative treatment is fiberoptic bronchoscopes interventional treatment.

  15. Adenoid Cystic Carcinoma of the Nasal Cavity and Paranasal Sinuses

    Amit, Moran; Binenbaum, Yoav; Sharma, Kanika; Ramer, Naomi; Naomi, Ramer; Ramer, Ilana; Ilana, Ramer; Agbetoba, Abib; Abib, Agbetoba; Miles, Brett; Yang, Xinjie; Lei, Delin; Bjoerndal, Kristine; Godballe, Christian; Mücke, Thomas; Thomas, Mücke; Wolff, Klaus-Dietrich; Klaus-Dietrich, Wolff; Fliss, Dan; Eckardt, André M; Copelli, Chiara; Chiara, Copelli; Sesenna, Enrico; Palmer, Frank; Frank, Palmer; Patel, Snehal; Gil, Ziv

    2013-01-01

    Objectives To identify independent predictors of outcome in patients with adenoid cystic carcinoma (ACC) of the paranasal sinuses and skull base. Design Meta-analysis of the literature and data from the International ACC Study Group. Setting University-affiliated medical center. Participants The...

  16. Comprehensive Cytomorphologic Analysis of Pulmonary Adenoid Cystic Carcinoma: Comparison to Small Cell Carcinoma and Non-pulmonary Adenoid Cystic Carcinoma

    Kim, Seokhwi; Chu, Jinah; Kim, HoJoong; Han, Joungho

    2015-01-01

    Background: Cytologic diagnosis of pulmonary adenoid cystic carcinoma (AdCC) is frequently challenging and differential diagnosis with small cell carcinoma is often difficult. Methods: Eleven cytologically diagnosed cases of pulmonary AdCC were collected and reviewed according to fifteen cytomorphologic characteristics: small cell size, cellular uniformity, coarse chromatin, hyperchromasia, distinct nucleolus, frequent nuclear molding, granular cytoplasm, organoid cluster, sheet formation, ir...

  17. Microbiological Profile of Adenoid Hypertrophy Correlates to Clinical Diagnosis in Children

    Szalmás, Anita; Papp, Zoltán; Csomor, Péter; Kónya, József; Sziklai, István; Szekanecz, Zoltán; Karosi, Tamás

    2013-01-01

    Objective. Adenoid hypertrophy is a common condition in childhood, which may be associated with recurring acute otitis media (RAOM), otitis media with effusion (OME), and obstructive sleep apnea syndrome (OSAS). These different clinical characteristics have some clinical overlap; however, they might be explained by distinct immunologic and infectious profiles and result in various histopathologic findings of adenoid specimens. Methods. A total of 59 children with adenoid hypertrophy undergoin...

  18. Radiographic evaluation of adenoidal size in children: methods of measurement and parameters of normality

    Radiograph of the nasopharynx is still the most commonly used imaging method to investigate the adenoidal tissue. Due to the variety and complexity of proposed methods to measure the adenoid size, some radiologists prefer subjective evaluation, which can, however, be imprecise and inaccurate. We review and describe several methods to determine the adenoid size, taking into account the practicity, accuracy and precision with the aim of pointing out the best methods to be applied in daily routine practice. (author)

  19. Carcinome cellule vitreuse du col de l'utrus: propos d'un cas et revue de littrature

    Hakimi, Ihssane; Zazi, Abdelghani; Chahdi, Hafsa; Guelzim, Khalid; Kouach, Jaouad; Babahabib, Myabdellah; Elhassani, Myehdi; Rahali, Driss Moussaoui; Dehayni, Mohammed

    2015-01-01

    Le carcinome cellule vitreuse du col de l'utrus est un type de histologique rare de cancer du col de l'utrus qui survient un ge plus jeune, et s'associe au risque lev dchec thrapeutique et le pronostic est plus mauvais en comparaison au type cellulaire squameux. La radiothrapie est associe au risque diminu de rcidive. Le but de cette tude est de rcapituler travers d'une observation et une revue de littrature les donnes sur l'incidence, le comportement clinique et la survie globale de patients avec le carcinome cellule vitreuse du col de l'utrus. PMID:26664556

  20. Adenoid Cystic Carcinoma of Accessory Parotid Gland: A Case Report.

    Das, Somdipto; Nayak, Umanath K; Buggavetti, Rahul; Sekhar, Shobana

    2016-05-01

    The accessory parotid gland is salivary gland tissue separated from the main gland at a variable distance. This gland is histologically similar to the main gland, but has a higher incidence of malignant neoplasms than the main gland. Regarding the various malignant neoplasms, studies have shown higher incidences of mucoepidermoid carcinoma, with less than 2% being adenoid cystic carcinoma. We present a case of swelling in the midcheek region that, after clinical examination, was diagnosed as a case of neoplasm of the accessory parotid gland. On the basis of auxiliary investigations including intraoperative frozen section, it was concluded that it was adenoid cystic carcinoma, grade I, and after wide surgical resection, the tumor was removed without undergoing superficial parotidectomy. The patient received postoperative radiotherapy (RT) and was followed for 14 months without any recurrence or substantial facial asymmetry. PMID:26851989

  1. Discovery of Invasion Routes for Nasopharyngeal Adenoid Cystic Carcinoma

    DONG, JUN; Zhang, Liang; Mo, Yunxian; Tian, Li; Liu, Lizhi; Wu, Peihong

    2015-01-01

    The aim of this study is to discover regional invasion routes for nasopharyngeal adenoid cystic carcinoma (NACC) through analyses of the magnetic resonance (MR) images and comparison with keratinizing squamous cell carcinoma (KSCC). Both MR results and clinical records were retrospectively reviewed for 18 patients with NACC and 182 patients with KSCC. The metastasis routes of NACC were identified by analysis of MR images of patients who underwent magnetic resonance imaging (MRI). There were s...

  2. Le carcinome verruqueux de la vulve: à propos de quatre cas

    Boujoual, Majdouline; Hachi, Hafid; Rimani, Mouna; El Khannoussi, Basma; Bougtab, Abdesslam

    2014-01-01

    Le cancer verruqueux de la vulve est une variante rare et bien différenciéedu carcinome épidermoïdedont les particularités diagnostiques, thérapeutiques et pronostiques méritent d’être distinguées. Il se caractérise par son importante croissance exophytique sans infiltration de la membrane basale. Son évolution est surtout locale rarement métastatique. Il est l'indication d'un traitement chirurgical exclusif avec exérèse large sans curage ganglionnaire de principe. La radiothérapie n'apporte ...

  3. ROLE OF ADENOID AND NASOPHARYNGEAL FLORA IN THE ETIOLOGY OF SEROUS OTITIS MEDIA

    Akshay

    2015-09-01

    Full Text Available OBJECTIVES: To identify the common bacteria found in the nasopharynx of patients of serous otitis media, to study the prevalence of adenoiditis in patient of serous otitis media and to study the bacteria isolated from operated adenoid tissue of patients of serous otitis media. METHOD AND MATERIA LS : Study was carried out on clinically diagnosed 40 cases of serous otitis media. Patients were operated under general anaesthesia. At the commencement of the surgery, a sterile swab was taken with an applicator from the surface of the adenoid. Prior to surgery, the adenoid tissue was palpated and confirmed. Adenoidectomy was done by curettage method using adenoid curette and the specimen was immediately transported in normal saline to the microbiology lab in a sterile bottle along with the surface swab. RESULT: 95% culture shows bacterial growth , males are more common in serous otitis media and most bacteria isolated from nasopharyngeal swab and adenoid are Gram positive bacteria includes Streptococcus pneumoniae, Staphylococcus aureus, Enterococcus species, Streptococcus viridians, Streptococcus pyogenes and Gram negative bacteria includes Moraxella catarrhalis, Klebsiella pneumonia. CONCLUSION: T he nasopharyngeal and adenoid bacterial flora is polymicrobial in nature and there is no difference in the pathogens isolated from nasopharynx swab or adenoid culture in patients of serous otitis media.

  4. Carcinome pidermode de la vulve sur une grossesse gmellaire: propos dun cas aux cliniques universitaires de Lubumbashi

    Idi, Yves Isango; Muteya, Michel Manika; Ngama, Christian Kakisingi; Mwazaz, Roger Munan; Makinko, Paul Ilunga; Kaj, Fanny Malonga; Tambwe, Albert Mwembo; Mukalenge, Faustin Chenge

    2013-01-01

    Nous rapportons un cas de carcinome pidermode de la vulve chez gestante porteuse dune grosse gmellaire qui a consult dans le service de gynco-obstetrique des Cliniques Universitaires de Lubumbashi un stade avanc de la pathologie et aprs avoir essay un traitement insuffisant ailleurs.

  5. Montelukast in Adenoid Hypertrophy: Its Effect on Size and Symptoms

    Shokouhi, Farshid; Meymaneh Jahromi, Ahmad; Majidi, Mohamad Reza; Salehi, Maryam

    2015-01-01

    Introduction: Adenotonsillar hypertrophy (AH) is considered the most common cause of upper respiratory tract obstruction among children. It results in a spectrum of symptoms from mouth breathing, nasal obstruction, hyponasal speech, snoring, and obstructive sleep apnea (OSA) to growth failure and cardiovascular morbidity. Adenotonsillectomy is a typical strategy for patients with AH, but may lead to serious complications such as bleeding (45%) and postoperative respiratory compromise (27%), especially among young children, as well as recurrence of adenoid tissue (1020%). Thus, non-surgical therapies have attracted considerable attention as an alternative strategy. The inflammatory mechanism proposed for AH has lead to the use of anti-inflammatory drugs to manage this condition. The present study aimed to evaluate the effect of chewable tablets of montelukast, a cysteinyl- leukotriene receptor antagonist, in children with AH. Materials and Methods: Sixty children between the ages of 412 years with >75% choanal obstruction on primary nasal endoscopy were recruited in this randomized, placebo-controlled trial and randomly divided into two groups. The study group was treated with montelukast 5 mg daily for 12 weeks while the control group received matching placebo for the same period of time. A questionnaire was completed by each childs parent/guardian to assess the severity of sleep discomfort, snoring, and mouth breathing before and after the intervention. Results: Adenoid size decreased in 76% of the study group compared with 3% of the placebo group after 12 weeks. A statically significant improvement was observed in the study group compared with the placebo group in terms of sleep discomfort, snoring, and mouth breathing. The symptoms average total score dropped from 7.7 to 3.3 in the study group, while in the placebo group the total score changed from 7.4 to 6.7. Conclusion: Montelukast chewable tablets achieved a significant reduction in adenoid size and improved the related clinical symptoms of AH and can therefore be considered an effective alternative to surgical treatment in children with adenoid hypertrophy. PMID:26788489

  6. Prevalence of the Helicobacter pylori in the tonsils and adenoids

    Tuba Bayindir

    2015-06-01

    Full Text Available INTRODUCTION: There is an ongoing debate about the existence and effects of Helicobacter pylori (Hp in adenotonsillar tissue. OBJECTIVE: A clinical study was conducted to assess the existence of Hp in the adenoid and/or adenotonsillar tissues, which were surgically excised due to chronic adenotonsillitis. METHODS: Phosphoglucosamine mutase gene for the detection of Hp and cytotoxin-associated gene as virulence gene were examined in 84 adenotonsillar tissues obtained from 64 patients and patients' serum by using polymerase chain reaction. RESULTS: Hp IgG was detected in 57 (89% patients' serum. A total of seven tissue samples from 64 patients (10.9% were found positive for Hp DNA, of which five were adenoids and two were tonsil tissues. All polymerase chain reaction positive samples were also positive for the cytotoxin-associated gene, which is a virulence determinant for the organism. CONCLUSION: This study suggests that children are exposed to Hp at an early age of their life in this province. Hp may have a role in the pathogenesis of chronic adenotonsillitis, especially in endemic areas.

  7. Carcinoma adenoide qustico parotdeo: soluciones estticas y funcionales / Adenoid Cystic Carcinoma of the Parotid: an Aesthetic and Functional Solutions

    Raquel, Villar; Manuel, Acosta; Benito, Ramos; Juan Jos, Haro; Antonio, Gmez; Toms, Esteban; Ramss, Caraballo.

    2014-09-01

    Full Text Available El carcinoma adenoide qustico supone el 10-30% de las neoplasias malignas parotdeas, su tratamiento se basa en una parotidectoma que incluya el tumor con un adecuado margen de seguridad y la radioterapia postoperatoria dado que permite mejorar el control locorregional de la enfermedad. Revisamos [...] un caso que permite exponer el manejo de las secuelas funcionales y estticas derivadas de su tratamiento. Consideramos adecuada la reconstruccin inmediata del nervio facial cuando se encuentra clnicamente afecto o englobado por el tumor; as como suplir el defecto de volumen posparotidectoma con un colgajo local. Proponemos la anastomosis nerviosa con injerto de nervio sural de las ramas del nervio facial afectas y el relleno del defecto volumen posparotidectoma con un colgajo de fascia temporo-parietal. Abstract in english Adenoid cystic carcinoma represents 10-30% of all malignant neoplasms in the parotid gland. Treatment is a formal parotidectomy, which includes removing the tumour with an adequate margin and postoperative radiotherapy to improve the locoregional control of the disease. We report a case in order to [...] present the management of the functional and aesthetic consequences obtained from its treatment. When the facial nerve is clinical affected or involved by the tumour, it requires resection and an immediate reconstruction. We suggest the sural nerve graft for the reconstruction of the affected facial branches and the temporo-parietal fascia flap to fill the volume left by the parotidectomy.

  8. Carcinome neuroendocrine du sein: à propos d'un cas et revue de la littérature

    El Fatemi, Hinde; Hammas, Nawal; Moumna, Kaoutar; Bedahou, Mouhcine; Mellas, Nawfel; Mesbahi, Omar

    2012-01-01

    Le carcinome neuroendocrine primitif du sein est une tumeur rare qui a été reconnue par la dernière édition de la classification OMS du cancer du sein publiée en 2003. Le diagnostic est évoqué sur des critères morphologiques et confirmé par l'expression des marqueurs neuroendocrines (chromogranine et synaptophysine) par plus de 50% des cellules tumorales. Nous rapportons un nouveau cas de carcinome neuroendocrine primitif du sein, et à travers une revue de la littérature, nous détaillons les aspects épidémiologiques, morphologiques et immuno-histochimiques de cette tumeur rare. PMID:23330031

  9. Carcinome mucineux primitif cutané: à propos de deux cas et d'une revue de la literature

    Souaf, Ihsane; Ameurtesse, Hassania; Debbagh, Fatema Zehra; Idrissi, Karima; Znati, Kawter; Amarti, Affaf

    2014-01-01

    Le carcinome mucineux primitif cutané est une tumeur annexielle rare, développée à partir des glandes sudoripares. Il se localise en générale à l'extrémité céphalique, surtout la région périorbitaire. Nous rapportons deux observations d'un carcinome mucineux primitif de la face et de la région axillaire, chez deux patients âgés de 60 ans. L’étude histologique montrait une prolifération tumorale dermohypodermique, faite de cellules organisées en cordons, en amas et en massif cribriformes, au sein d'une substance mucoïde. En immunohistochimie les cellules tumorales exprimaient la cytokératine 7, l'EMA et les récepteurs hormonaux. L'actine musculaire lisse a bien marqué les cellules myoépithéliales au niveau de la composante in situ dans un seul cas. Le carcinome mucineux primitif cutané est difficile à différencier d'une métastase mammaire ou digestive. La mise en évidence de carcinome in situ ou de cellules myoépithéliale est en faveur de l'origine cutanée primitive. C'est une tumeur à croissance lente, avec des métastases exceptionnelles. Le traitement est chirurgical et le taux de récidive est très élevé. Et à travers ces deux observations, les auteurs mettent en relief les principaux aspects cliniques, histologiques, thérapeutiques de cette entité avec une revue de la littérature. PMID:25574316

  10. Adenoid cystic carcinoma of the mobile tongue: A rare case

    Pavitra Baskaran

    2012-01-01

    Full Text Available Adenoid cystic carcinoma (ACC occurs more commonly in the minor salivary glands of the palate on than the tongue. ACC is a malignant neoplasm that accounts for 1-2% of all head and neck malignancies and 10-15% of all salivary gland malignancies. ACC affects the exocrine glands at any site, but the parotid gland is the most common site in the head and neck region. Many factors should be taken into account in the prognosis of ACC, including the histological and clinical stages of the disease. The most striking feature of ACC is that it is locally aggressive, with a high recurrence level, perineural invasion and distant metastases, especially to the lungs and bones. The most common presentation histologically is the presence of cribriform appearance (Swiss cheese pattern. The present case is a rare one present on the tongue.

  11. Intraosseous adenoid cystic carcinoma of maxilla: A rare case report

    Prasannasrinivas Suresh Deshpande

    2013-01-01

    Full Text Available Adenoid cystic carcinoma (ACC accounts for approximately 6-10% of all salivary gland tumors. Palatal minor salivary glands, parotid, and sub-mandibular glands are usually affected. Rarely, these lesions arising intraosseously have been reported. Mandible is commonly involved than maxilla. The present case is a giant ACC involving the right maxilla. A thorough clinical and radiographic evaluation was performed to assess the involvement of surrounding vital structures along with a meticulous metastatic work-up. Computed tomography showed a giant lesion in maxilla encroaching the left nasal fossa, antrum, buccal space, and oral cavity. No metastasis was noted. Histological evaluation from multiple sites showed both cribriform and solid patterns. Radiotherapy was given as patient did not comply for surgery. Though central ACC is extremely rare, especially in maxilla, it should be included in the differentials for lesions in maxilla. A prompt diagnosis with treatment and long-term follow-up is advised in such cases.

  12. Adenoid Cystic Carcinoma of the Nasal Cavity and Paranasal Sinuses

    Amit, M.; Binenbaum, Y.; Sharma, K.; Naomi, R.; Ilana, R.; Abib, A.; Miles, B.; Yang, X. J.; Lei, D.; Bjrndal, Kristine; Godballe, Christian; Thomas, M.; Klaus-Dietrich, W.; Fliss, D.; Eckardt, A. M.; Chiara, C.; Sesenna, E.; Frank, P.; Patel, S.; Gil, Z.

    2013-01-01

    Objectives To identify independent predictors of outcome in patients with adenoid cystic carcinoma (ACC) of the paranasal sinuses and skull base. Design Meta-analysis of the literature and data from the International ACC Study Group. Setting University-affiliated medical center. Participants The......%, respectively. The local recurrence rate was 36.6%, and the regional recurrence rate was 7%. Distant metastasis, most commonly present in the lung, was recorded in 106 patients (29.1%). In the international cohort, positive margins and ACC of the sphenoid or ethmoidal sinuses were significant predictors of...... outcome (p <0.001). Perineural invasion and adjuvant treatment (radiotherapy or chemoradiation) were not associated with prognosis. Conclusion Tumor margin status and tumor site are associated with prognosis in ACC of the paranasal sinuses, whereas perineural invasion is not. Adjuvant treatment apparently...

  13. Adenoid cystic carcinoma of sublingual glands. Surgery and radiotherapy combination

    The Adenoid Cystic Carcinoma (ACC) or Cilindroma is a strange entity classified by the WHO within the carcinomas of salivary glands. It represents only 1 % of all the wicked tumours of the oral and maxillofacial region although, when making reference to the salivary glands, it constitutes 5% of the parotid, submaxilar and sublingual carcinomas, and about 50% of the smallest ones. The most frequent location is in the palatine glands and its main characteristics are: slow but persistent growth, high rates of local relapse and metastasis at distance originating the death between the first 5 and 10 years in 50-70% of the cases approximately. A case of localization is presented in sublingual gland which was first treated surgically and later with radiotherapy, obtaining good results. (author)

  14. Adenoid carcinoma cystic of trachea. A case report

    The tumours of trachea are not frequent. Within them, the adenoid carcinoma cystic is a rare malign tumour and it has been demonstrated that it does not relate to each other significant whit tobacco addiction. In this work we present the case of female patient of 45 years old who went to the urgency room with out of breath accompanied of humid cough with greenish abundant expectoration, fever to 39C and loss of 6 heavy kg in 6 months. The X-ray of thorax sold off in service of urgencies was normal and the doctors imposed treatment no obtaining answer to him. Computerized tomography scanner was made showing the presence of a tracheal lesion

  15. Macroglossia caused by adenoid cystic carcinoma. Case report.

    Luna Ortiz, Kuauhyama; Carmona Luna, Tania; Herrera Gmez, Angel; Cano Valdez, Ana Maria

    2008-06-01

    A 33-year-old woman sought medical care at our institution for macroglossia. She had been treated before with tracheostomy and gastrostomy due to an adenoid cystic carcinoma (ACC) of the mobile tongue, in clinical stage IVC. She was subjected to total glossectomy with larynx preservation, modified radical dissection of the right neck and of the left supraomohyoid muscle, as well as reconstruction using a free flap from the rectus abdominus. The histological report described a 15x11 cm solid type ACC of the mobile tongue (grade III), with infiltration to adjacent soft tissues, vascular and lymphatic vessels, as well as two metastatic lymph nodes in the right neck dissection. One month after surgery, bone and bilateral pulmonary tumor activity became evident. In advanced-stage tumors, treatment must be individualized, and when accompanied by severe deterioration of the quality of life, surgery is recommended independently from the extension, provided that a good reconstruction is accomplished. PMID:18521061

  16. Radiographic evaluation of adenoidal size in children with allergic perennial rhinitis: still the current method

    Adenoid hypertrophy is known to be the most common cause of nasal obstruction in children; thus, adenoidectomy is one of the most commonly performed surgical procedures in children. Clinical assessment of adenoidal size is difficult, and objective measurement is desirable. The study included 39 children (17 girls and 22 boys, 5-9 years of age, mean age: 6.7 years) with signs of perennial allergic rhinitis and suspicion of adenoidal hypertrophy. To establish the best radiological method to measure the adenoidal size, three different procedures (Johanneson, Fuijoka, and Cohen/Konak) were used. The methods were evaluated against the degree to which the adenoids obstructed the nasopharyngeal space on flexible endoscopy of the postnasal space. Clinical symptomatology was also evaluated against the degree of obstruction. To estimate the correspondence between the results, we used Spearman's correlation test.The radiological method that best correlated with the endoscopic findings was that of Cohen and Konak, but neither radiology nor endoscopic scores correlated well with clinical symptoms. Conclusion: The side-adenoid assessment in allergic children. (author)

  17. Evaluation of the relation between adenoids hypertrophy and cranial base angles

    Dalili Z

    2006-07-01

    Full Text Available Background and Aim: Adenoids are normally large in children and their size starts to reduce during adolescence. Hypertrophic adenoids could be associated with allergic reactions. Enlarged adenoids result in nasal breathing difficulties and the child is forced to switch to mouth breathing. Airway obstruction causes postural alterations of jaw, tongue and head, and due to persistent obstruction, patient’s appearance changes to adenoid face. Evaluation of nasopharyngeal space in lateral cephalometic view is a simple and repeatable method for determination of the size and shape of adenoids and nasopharyngeal space which can provide a simple measurement of nasopharyngeal obstruction. The roof of nasopharyngeal space is covered by the sphenoid bone. Thus changes of nasorespiratory resistance by hypertrophic adenoids may affect the cranial base angles. In this study, the relationship between adenoid hypertrophy and cranial base angles was investigated. Materials and Methods: In this descriptive-analytic study, lateral cephalometric views of 7 to 14 y/o patients from the files of orthodontic centers in Rasht city were selected. The radiographs with proper resolution were separated for this research. Adenoid to nasorespiratory ratio (A/N Ratio was determined by Fujioka method and categorized in three groups: A (A/N 0.8, B (0.5adenoid hypertrophy (A and B groups was observed in 66% of cases whereas 34% were normal. The frequency of narrow, normal and wide cranial base angles in lateral ceph views was 28%, 30% and 42% respectively. There was significant difference among different cranial base angle regarding the presence or absence of adenoid hypertrophy (P<0.001. According to Pearson coefficient, there was significant relation between A/N ratio groups and different cranial base angles (R=0.2. Conclusion: Based on the results of this study, little correlation exists between A/N ratio and cranial base angle. Further studies are recommended to investigate the possible effects of other factors such as genetics and the environment.

  18. Neutron radiotherapy for adenoid cystic carcinoma of minor salivary glands

    Purpose: To examine the efficacy of fast neutron radiotherapy for the treatment of patients with locally advanced, adenoid cystic carcinoma of minor salivary glands and to identify prognostic variables associated with local control, overall survival, and cause specific survival. Methods and Materials: Eighty-four patients having adenoid cystic carcinoma of minor salivary glands were treated with fast neutron radiotherapy during the years 1985-1994. All patients had either unresectable disease or gross disease remaining after attempted surgical extirpation. Seventeen patients had previously received conventional radiotherapy and their subsequent treatment fields and doses for neutron radiotherapy were modified for critical sites (brainstem, spinal cord, brain). Although the median doses (tumor maximum and tumor minimum) only varied by ≤10%, treatment portals were substantially smaller in these patients because of normal tissue complication considerations. Twelve patients (13%) had distant metastases at the time of treatment and were only treated palliatively with smaller treatment portals and lower median tumor doses (≤80% of the doses delivered to curatively treated patients). Seventy-two patients were treated with curative intent, with nine of these having recurrent tumors after prior full-dose radiotherapy. The median duration of follow-up at the time of analysis was 31.5 months (range 3-115). Sites of disease and number of patients treated per disease site were as follows: paranasal sinus--31; oral cavity--20; oropharynx--12; nasopharynx--11; trachea--6; and other sites in the head and neck--4. Results: The 5-year actuarial local-regional tumor control rate for all patients treated with curative intent was 47%. Patients without involvement of the cavernous sinus, base of skull, or nasopharynx (51 patients) had a 5-year actuarial local-regional control rate of 59%, whereas local-regional control was significantly lower (15%) for patients with tumors involving these sites (p < 0.005). In the latter cases, normal tissue injury considerations precluded delivery of the full dose to the entire tumor. Patients with no history of prior radiotherapy (63 patients) had an actuarial local control rate of 57% at 5 years compared to 18% for those (9 patients) who had been previously irradiated with conventional photons (p = 0.018). Eliminating the dose-limiting factors of prior radiation therapy and/or high risk sites of involvement, the 5-year actuarial local-regional control rate for these 46 patients was 63%, with an actuarial cause specific survival rate of 79%. Lymph node status was a predictor of distant metastasis: 57% of node positive patients developed distant metastases by 5 years compared to 15% of patients with negative nodes (p < 0.0005), and patients who had nodal involvement developed distant metastases sooner than node negative patients (p < 0.0001). The 5-year actuarial overall survival and cause specific survival for the 72 patients treated with curative intent were 59% and 64%, respectively. Conclusions: Fast neutron radiotherapy offers high local-regional control and survival rates for patients with locally advanced, unresectable adenoid cystic carcinomas of minor salivary glands. It should be considered as initial primary treatment for these patients, as well as for other patients in whom surgical extirpation would cause considerable morbidity

  19. Radiologic evaluation of adenoids and tonsils in children with obstructive sleep apnea: Plain films and fluoroscopy

    Twenty-six children with obstructive sleep apnea were evaluated by lateral neck radiographs during wakefulness, and by polygraphic monitoring and upper airway fluoreoscopy during natural sleep. Children with craniofacial abnormalities, palatal surgery, and central nervous system disease were excluded from the study. Moderate or marked enlargement of tonsils and adenoids was noted on lateral neck radiographs of 18 of 26 patients. An objective measure of adenoidal enlargement, the adenoidal-nasopharyngeal ratio, correlated well with subjective judgment of adenoidal size but was not generally more useful than subjective estimation. Upper airway fluroescopy demonstrated the site and mechanism of obstruction in all patients. Because all children with moderate to marked adenotonsillar enlargement demonstrated obstruction at the adenoidal or tonsillar level on fluoroscopy, we now screen children with suspected sleep apnea with lateral airway radiographs and polysomnography. Fluoroscopy is reserved for children with mild adenotosillar enlargement, craniofacial dysplasia, prior cleft palate repair, or neuromuscular disorders. These results suggest that the pathogenesis of obstuctive sleep apnea in children involve anatomic factors which narrow the upper airway, sleep-related hypotonia of pharyngeal dilator musculature, and compensatory mechanisms to prevent or alleviate asphyxia. (orig.)

  20. The value of radiological examination in the management of adenoidal hypertrophy in a pediatric population

    The objective of this study is to evaluate the role of radiological examination in the management of adenoidal hypertrophy. A retrospective study was carried out in the North West Armed Forces Hospital, Tabuk, Kingdom of Saudi Arabia on pediatric patients who had x-ray of lateral nasopharynx to exclude adenoidal hypertrophy, January 2001 to December 2001. The study included ; the age of patient, sex and reason for radiology examination and management rendered. A total of two hundred and ninety- seven pediatric patients were involved. Two hundred and thirteen males (71.7%) and 84(28.3%) females, age ranged between 2 months and 12 years. The reason given for radiological examination was one or more of following symptoms snoring,mouth breathing recurrent tonsillitis, runny nose, deafness and obstructive sleep apnea.Small adenoids reported in 63 patients (21.2%)and were treated for their complaints by primary physician. Two hundred and thirty four patients (78.8%) with large adenoids were referred to the otolaryngology department of these 33 patients lost follow up. One hundred and nineteen referred(40.1%) patients were treated conservatively, while 82 patients (27.6%) who showed resistance to medical treatment under went adeniodectomy with or without other related surgical procedures. It was concluded that radiological examination in the management of adenoidal hypertrophy had a limited role, increased Radiological Department workload wastage of resources in addition to unnecessary radiation exposure. (author)

  1. Lapatinib in Treating Patients With Recurrent and/or Metastatic Adenoid Cystic Cancer or Other Salivary Gland Cancers

    2013-10-10

    High-grade Salivary Gland Carcinoma; High-grade Salivary Gland Mucoepidermoid Carcinoma; Low-grade Salivary Gland Carcinoma; Low-grade Salivary Gland Mucoepidermoid Carcinoma; Recurrent Adenoid Cystic Carcinoma of the Oral Cavity; Recurrent Salivary Gland Cancer; Salivary Gland Acinic Cell Tumor; Salivary Gland Adenocarcinoma; Salivary Gland Adenoid Cystic Carcinoma; Salivary Gland Malignant Mixed Cell Type Tumor

  2. Clinical study of adenoid cystic carcinoma of the parotid gland

    We report results of a retrospective study of 12 cases of adenoid cystic carcinoma (ACC) in the parotid gland. Local pain was often observed in ACC among other malignant parotid tumors. Although fine-needle aspiration cytology (FNA) was not effective for preoperative diagnosis, frozen section diagnosis (FS) during surgery showed excellent results. Cases with T3 or T4 underwent total or enlarged parotidectomy, but, often showed positive surgical margins. Postoperative radiation therapy seemed useful in these cases and the 5- and 10- year disease-specific survivals in these 12 cases were 90.0% and 80.8%. These compare favorably with other reports in the literature. All 12 cases showed N0 and no cervical relapse with or without neck dissection, indicating little effectiveness in prophylactic neck dissection. Tumor size, positive surgical margins, and perineural invasion are risk factors for this tumor as mention previously. Patients with perineural invasion, especially preoperative facial nerve palsy (T4a), are more likely to fail than those with two other factors, so, it seems conceivable for cases of T4a to undergo more positive treatment with surgery and postoperative radiation. (author)

  3. Pulmonary artery stent for bronchial adenoid cystic carcinoma causing pulmonary artery stenosis

    Smith, Corey Allister; Kotlyar, Eugene; Mellemkjaer, Soren; Muller, David; Stone, Emily

    2014-01-01

    A 46-year-old woman presented with a 6-month history of dyspnea and weight loss on a background of previous pneumonectomy for bronchial adenoid cystic carcinoma 14 years beforehand. Several years prior to this presentation, she had developed left vocal cord palsy and a metastatic lesion to the...... improved both pulmonary artery pressures and the patient's symptoms. The diagnosis of pulmonary artery stenosis due to mediastinal infiltration by metastatic bronchial adenoid cystic carcinoma was based on these findings as well as the presence of the pulmonary nodules and the previous mediastinal...

  4. Cystic adenoid carcinoma of the external auditory meatus with mastoid involvement

    Tinoco, Paulo

    2009-06-01

    Full Text Available Introduction: The cystic adenoid carcinoma (CAC in the external auditory meatus is rare and was originated in the ceruminous glands. It is manifested by otalgia in about 90% of the patients. Case Report: In this article we report the case of a patient with Cystic Adenoid Carcinoma of the external auditory meatus with mastoid involvement that presented peripheral facial paralysis. The treatment is essentially surgical, combined or not with postoperative radiotherapy. The factors of bad prognosis are the tumor expansion, facial nerve and middle ear invasion and lymph node affection, which diminish the survival in five years from 59% to 23%.

  5. Application of p16 Immunohistochemistry and RNA In Situ Hybridization in the Classification of Adenoid Basal Tumors of the Cervix.

    Goyal, Abha; Wang, Zhen; Przybycin, Christopher G; Yang, Bin

    2016-01-01

    Our understanding of adenoid basal tumors of the cervix has evolved over time. Most of the proliferations referred to as adenoid basal carcinoma have a clinically benign course-leading some to suggest the term "adenoid basal epithelioma." However, rarely, these may be associated with invasive carcinomas. These tumors have been etiologically linked with high-risk human papillomavirus (HR-HPV) infection. Here, we investigate the use of p16 immunohistochemistry and HR-HPV RNA in situ hybridization (ISH) in the classification of adenoid basal tumors of the cervix. Seventeen cases of adenoid basal tumors of the cervix were included. The patients' age ranged from 19 to 79 yr (average, 59 yr). p16 immunostain was performed on all cases and RNA ISH was performed in 4 cases with available formalin-fixed paraffin-embedded tissue. There were 11 low-grade tumors, 5 frankly invasive carcinomas, and 1 with histologic features that were intermediate between the former 2 categories. p16 immunostain was negative or showed patchy cytoplasmic staining in the low-grade tumors and was strongly and diffusely positive in the invasive carcinomas. HR-HPV RNA ISH was negative in the 3 low-grade tumors and was positive in 1 case of invasive carcinoma including the adenoid basal component. Distinct p16 immunostaining and HR-HPV RNA ISH patterns exist between low-grade adenoid basal tumors and invasive adenoid basal carcinomas. Our study indicates that p16 immunostaining and HR-HPV RNA ISH can be employed as useful ancillary tools in differentiating between noninvasive and invasive adenoid basal tumors along with careful histopathologic evaluation. PMID:26352551

  6. Detection of Respiratory Viruses and Atypical Bacteria in Children's Tonsils and Adenoids?

    Drago, Lorenzo; Esposito, Susanna; Vecchi, Elena De; Marchisio, Paola; Blasi, Francesco; Baggi, Elena; Capaccio, Pasquale; Pignataro, Lorenzo

    2007-01-01

    The tonsils and adenoids of 44 children were analyzed for the detection of respiratory syncytial virus, influenza virus, parainfluenza virus, adenovirus, Chlamydophila pneumoniae, and Mycoplasma pneumoniae. Viruses were detected in 47.7% of the children and 37.3% of the specimens, with adenovirus and parainfluenza viruses being the most frequently detected microorganisms.

  7. Elective Neck Dissection in Patients With Head and Neck Adenoid Cystic Carcinoma

    Amit, Moran; Na'ara, Shorook; Sharma, Kanika; Ramer, Naomi; Ramer, Ilana; Agbetoba, Abib; Glick, Joelle; Yang, Xinjie; Lei, Delin; Bjoerndal, Kristine; Godballe, Christian; Mücke, Thomas; Klaus-Dietrich, Wolff; Eckardt, André M; Copelli, Chiara; Sesenna, Enrico; Palmer, Frank; Ganly, Ian; Gil, Ziv

    2015-01-01

    BACKGROUND: Adenoid cystic carcinoma (ACC) accounts for 3-5 % of all head and neck malignancies. Investigations of outcomes from elective neck dissection (END) for patients with ACC are sparse. This study aimed to assess the impact of END on the survival of patients with ACC. METHODS: This...

  8. Nomograms for predicting survival and recurrence in patients with adenoid cystic carcinoma. An international collaborative study

    Ganly, Ian; Amit, Moran; Kou, Lei; Palmer, Frank L; Migliacci, Jocelyn; Katabi, Nora; Yu, Changhong; Kattan, Michael W; Binenbaum, Yoav; Sharma, Kanika; Naomi, Ramer; Abib, Agbetoba; Miles, Brett; Yang, Xinjie; Lei, Delin; Bjoerndal, Kristine; Godballe, Christian; Mücke, Thomas; Wolff, Klaus-Dietrich; Fliss, Dan; Eckardt, André M; Chiara, Copelli; Sesenna, Enrico; Ali, Safina; Czerwonka, Lukas; Goldstein, David P; Gil, Ziv; Patel, Snehal G

    2015-01-01

    BACKGROUND: Due to the rarity of adenoid cystic carcinoma (ACC), information on outcome is based upon small retrospective case series. The aim of our study was to create a large multiinstitutional international dataset of patients with ACC in order to design predictive nomograms for outcome...

  9. An Interesting Pathological Diagnosis – Adenoid Cystic Carcinoma in an Adolescent Girl

    Sachin B. Ingle; Jamadar, Nawab P; Adgaonkar, Baban D; Chitra R. Hinge (Ingle); Saleha Siddiqui

    2015-01-01

    Adenoid cystic carcinomas (ACCs) constitute 0.1–1 % of all malignant breast tumors. They have better prognosis than other breast malignancies. To date, there have been about 933 cases reported as per English literature. To the best of our knowledge, this case may be the second well-documented case of ACC of breast at younger age.

  10. International collaborative validation of intraneural invasion as a prognostic marker in adenoid cystic carcinoma of the head and neck

    Amit, Moran; Binenbaum, Yoav; Trejo-Leider, Leonor; Sharma, Kanika; Ramer, Naomi; Ramer, Ilana; Agbetoba, Abib; Miles, Brett; Yang, Xinjie; Lei, Delin; Bjørndal, Kristine; Godballe, Christian; Mücke, Thomas; Wolff, Klaus-Dietrich; Eckardt, André M; Copelli, Chiara; Sesenna, Enrico; Palmer, Frank; Ganly, Ian; Patel, Snehal; Gil, Ziv

    2015-01-01

    BACKGROUND: The purpose of this study was to characterize the incidence, pattern of spread, and prognostic correlation of nerve invasion in patients with adenoid cystic carcinoma (ACC). METHODS: Using 3 different pathological categories of perineural invasion, intraneural invasion, and perineural...

  11. THE PRESENCE OF ADENOID VEGETATIONS AND NASAL SPEECH, AND HEARING LOSS IN RELATION TO SECRETORY OTITIS MEDIA

    Gabriela KOPACHEVA

    2004-12-01

    Full Text Available This study presents the treatment of 68 children with secretory otitis media. Children underwent adenoid vegetations, nasal speech, conductive hearing loss, ventilation disturbance in Eustachian tube. In all children adenoidectomy was indicated.38 boys and 30 girls at the age of 3-17 were divided in two main groups: * 29 children without hypertrophic (enlarged adenoids, * 39 children with enlarged (hypertrophic adenoids.The surgical treatment included insertion of ventilation tubes and adenoidectomy where there where hypertrophic adenoids.Clinical material was analyzed according to hearing threshold, hearing level, middle ear condition estimated by pure tone audiometry and tympanometry before and after treatment. Data concerning both groups were compared.The results indicated that adenoidectomy combined with the ventilation tubes facilitates secretory otitis media heeling as well as decrease of hearing impairments. That enables prompt restoration of the hearing function as an important precondition for development of the language, social, emotional and academic development of children.

  12. Growth of the nasopharynx and adenoidal development in Brazilian subjects Crescimento da nasofaringe e desenvolvimento da adenide em brasileiros

    Beatriz de Souza Vilella; Oswaldo de Vasconcelos Vilella; Hilton Augusto Koch

    2006-01-01

    The purpose of this research was to study the growth of the nasopharynx and adenoid development. Lateral cephalometric radiographs obtained from 320 white Brazilian subjects between 4 and 16 years of age were used. All the participants were nose breathers and none of them had previously undergone adenoidectomy. Tracings were made from the radiographs and cephalometric measurements were performed. The results showed that adenoid sagital thickness is larger in the age group 4 - 5 years and decr...

  13. Nasopharyngeal vs. adenoid cultures in children undergoing adenoidectomy: prevalence of bacterial pathogens, their interactions and risk factors.

    Korona-Glowniak, I; Niedzielski, A; Kosikowska, U; Grzegorczyk, A; Malm, A

    2015-03-01

    Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis and Staphylococcus aureus colonization of the adenoids and nasopharynx in 103 preschool children who underwent adenoidectomy for recurrent upper respiratory tract infections was examined. Bacterial interactions and risk factors for bacterial colonization of the nasopharynx and adenoids, separately, were analysed statistically. The prevalence of simultaneous isolation from both anatomical sites was 45·6% for S. pneumoniae, 29·1% for H. influenzae, 15·5% for M. catarrhalis and 18·4% for S. aureus. Three pathogens were significantly more frequent together from adenoid samples; nasopharyngeal swabs more often yielded a single organism, but without statistical significance. M. catarrhalis and S. aureus significantly more frequently co-existed with S. pneumoniae and H. influenzae than with each other and a positive association of S. pneumoniae and H. influenzae in adenoid samples was evident. Several differences between risk factors for nasopharyngeal and adenoid colonization by the individual pathogens were observed. We conclude that the adenoids and nasopharynx appear to differ substantially in colonization by pathogenic microbes but occurrence of H. influenzae and S. pneumoniae in the nasopharynx could be predictive of upper respiratory tract infections. PMID:25703401

  14. Carcinome épidermoïde du sein: à propos de 3cas et revue de la littérature

    Alaoui, Fatima Zohra Fdili; Benkirane, Saad; Chaara, Hekmat; Bouguern, Hakima; Melhouf, Moulay Abdilah

    2012-01-01

    Les carcinomes épidermoides du sein sont rares. Ils sont d'origine métaplasiques. Leur histogénèse est controversée. La présentation clinique et mammographique n'est pas spécifique, l'aspect kystisé des lésions et la présence de nécrose sont recherchés à l’échographie mammaire. Le diagnostic est histologique. Ce cancer est réputé être peu lymphophile et non hormonodépendant. Le traitement rejoint celui des carcinomes infiltrants canalaires et repose sur la chirurgie, la radiothérapie et la ch...

  15. Carcinoma adenoide cístico do conduto auditivo externo com envolvimento de mastoide

    Tinoco, Paulo

    2009-06-01

    Full Text Available Introdução: O carcinoma adenoide cístico (CAC no conduto auditivo externo é raro, tendo origem nas glândulas ceruminosas. Manifesta-se por otalgia em cerca de 90% dos pacientes. Relato do Caso: Neste artigo relatamos o caso de um paciente com Carcinoma Adenoide Cístico de conduto auditivo externo com envolvimento de mastoide que apresentava paralisia facial periférica. O tratamento é essencialmente cirúrgico, combinado ou não com radioterapia pós-operatória. Os fatores de mau prognóstico são a extensão do tumor, invasão do nervo facial e orelha média e acometimento linfonodal, diminuindo a sobrevida em cinco anos de 59% para 23%.

  16. [The comparative effectiveness of framycetin included in combined therapy of adenoiditis in the children].

    Soldatskiĭ, Iu L; Denisova, O A; Ivanenko, A M

    2014-01-01

    The objective of the present study was to evaluate the effectiveness of framycetin included in combined therapy of adenoiditis in the children. The study involved 67 children at the mean age of 6.9±2.7 years. Group 1 was comprised of 35 children given framycetin as topical therapy, the patients of group 2 were treated by the endonasal administration of a 2% silver proteinate solution. It was shown that the use of framycetin as a component of combined therapy of adenoiditis enhances the effectiveness of the treatment and compliance to therapy in comparison with the same parameters in the case of the application of traditional topical antibacterial preparations. PMID:25588492

  17. Cervical Lymph Node Metastasis: Unusual Presentation of Adenoid Cystic Carcinoma - Diagnosed By FNAC

    Archana Buch

    2015-01-01

    Full Text Available Adenoid cystic carcinoma (ACC is a rare neoplasm that usually arises from minor salivary glands. It is characteristically locally infiltrative, exhibiting perineural invasion, has a tendency for local recurrence and prolonged clinical course. A 60 year old male, chronic smoker presented with swelling of the left cervical lymph node since two months. Examination revealed a solitary firm, non tender, non mobile left cervical swelling measuring 2 x 1 cm. Fine Needle Aspiration Cytology (FNAC was done from the cervical lymph node. The diagnosis of metastatic deposits of ACC was given. Detail examination of the oral cavity revealed a small swelling at the floor of the mouth. Biopsy of the swelling confirmed ACC on histopathological examination. An unusual feature of adenoid cystic carcinoma is the low incidence of metastases to regional lymph nodes. The case is presented to highlight its unusual presentation and utility of FNAC in rapid diagnosis.

  18. Extradural Spinal Metastasis of Adenoid Cystic Carcinoma (ACC): A Case Report

    Vinod KUMAR; Nair, Rajesh; Upadhyaya, Sunil; Nayal, Bhavna; Shetty, Arjun

    2015-01-01

    Adenoid cystic carcinoma (ACC) is a rare malignant tumour of the major salivary glands. It accounts for 10-15% of all salivary gland tumours and 1% of all head and neck tumours. Surgical resection followed by radiation is the choice of treatment for ACC. However, late loco-regional recurrence and metastasis is often seen emphasizing the importance of long-term follow-up.

  19. Sinonasal adenoid cystic carcinoma following formaldehyde exposure in the operating theatre

    Sandvik, Anniken; Klingen, Tor Audun; Langrd, Sverre

    2014-01-01

    We present a case report of an auxiliary nurse who developed an adenoid cystic carcinoma in her left maxillary sinus following occupational exposure to formaldehyde in the operating theatre. Currently, the epidemiological evidence that formaldehyde can cause cancer in humans is considered to be limited. Previous case-control-studies of formaldehyde and sinonasal cancer have mainly investigated subjects who were concomitantly exposed to wood dust, a known risk factor to the development of sino...

  20. Primary adenoid cystic carcinoma of axillary ectopic breast tissue: Case report of a rare entity

    Anuj Sharma

    2016-01-01

    Full Text Available Ectopic breast tissue, a developmental anomaly, is a rare occurrence. Isolated pathologies in ectopic breast tissue with normal breast architecture are even rarer. Cases with primary invasive ductal carcinoma, invasive lobular carcinoma, secretory carcinoma, and mucinous carcinoma have been reported in ectopic breast tissue. We report a case of primary adenoid cystic carcinoma of axillary ectopic breast tissue, which to our belief has never been reported earlier.

  1. Primary cutaneous adenoid cystic carcinoma of the upper lid: a case report and literature review.

    Cavazza, Stefano; Laffi, Gian Luca; Lodi, Laura; Collina, Guido

    2012-02-01

    To report on the diagnostic challenge of an adenoid cystic carcinoma arising from the eyelid. A 77-year-old male was referred to our center with a clinical diagnosis of upper eyelid chalazion for a lesion that had appeared 2 years before. A loss of cilia was observed over the cutaneous area of induration, but there was no reddening or ulceration. Incisional biopsy was performed and the specimen was submitted in formalin for histopathological examination. On light microscopy, the lesion was composed of basaloid epithelial and myoepithelial cells that were arranged in strands or nests and associated with cystic spaces that contained a deeply eosinophilic secretory substance and an Alcian blue-positive material, characteristic of adenoid cystic carcinoma. After histological diagnosis, tumor re-excision was performed to ensure adequacy of resection margins, as well as a sentinel lymph node procedure, resulting in complete excision of the malignant tumor. No recurrence was observed during the first 18 months after surgery. Adenoid cystic carcinoma is a rare and aggressive epithelial malignancy, which tends to grow slowly and should be considered in the differential diagnosis of eyelid tumors simulating chalazion. PMID:22228272

  2. [Histopathological and immunological analysis of hyperplastic palatine tonsils and adenoids in children with coexisting atopic dermatitis].

    Modrzyński, Marek; Grochowski, Paweł; Zawisza, Edward; Lipiec, Agnieszka

    2003-01-01

    Allergic sensitisation of the airways occurs in the mucosa of the shock organ, or in the lymphatic stations draining these structures. The lymphatic structure closest to the nasal mucosa in humans is the adenoid and tonsils. Research done in respect to Waldeyer's ring on people dealing at the same time with allergy, is seldom the subject of dissertation in polish as well as world wide medical literature. In the enclosed dissertation, writers present the results of histopathological and immunohistochemical analysis of hyperplastic tonsils and adenoid, taken from children with coexisting atopy. The authors describe an immunohistochemical analyses of the hyperplastic human palatine tonsil. They present the expression of antigen CD3, CD20, CD45, CD68, EMA, SMA, Vimentin, Desmin, S-100, von Willebrand Factor, p35, Bcl-2, melanin, cytokeratin, estrogen receptor, progesteron receptor, kolagen IV and NSE in every region of pallatine tonsil. It is worthwhile to remark, that many of these cases, the presence of eosinophilia and subepithelial oedema was observed. Our immunohistochemical findings support the hypothesis that allergic sensitization takes place in the adenoid and tonsils. Furthermore, this study confirms that dendritic cells ad macrophages are involved and important in allergic disease. PMID:14593670

  3. Lower Female Genital Tract Tumors With Adenoid Cystic Differentiation: P16 Expression and High-risk HPV Detection.

    Xing, Deyin; Schoolmeester, J Kenneth; Ren, Zhiyong; Isacson, Christina; Ronnett, Brigitte M

    2016-04-01

    Lower female genital tract tumors with adenoid cystic differentiation are rare, and data on their relationship with high-risk human papillomavirus (HPV) are limited. Here we report the clinicopathologic features from a case series. Tumors with adenoid cystic differentiation, either pure or as part of a carcinoma with mixed differentiation, arising in the lower female genital tract were evaluated by means of immunohistochemical analysis for p16 expression and in situ hybridization using 1 or more probes for high-risk HPV (a high-risk probe covering multiple types, a wide-spectrum probe, and separate type-specific probes for HPV16 and HPV18) and when possible by polymerase chain reaction for high-risk HPV. Six cervical carcinomas with adenoid cystic differentiation admixed with various combinations of at least 1 other pattern of differentiation, including adenoid basal tumor (epithelioma and/or carcinoma), squamous cell carcinoma (basaloid or keratinizing), and small cell carcinoma were identified in patients ranging in age from 50 to 86 years (mean, 73 y; median, 76 y). All of these tumors were characterized by diffuse p16 expression. High-risk HPV was detected in 5 of 6 tested cases: 4 cases by in situ hybridization (all positive for HPV-wide-spectrum and HPV16) and 1 by polymerase chain reaction (HPV45). Seven pure adenoid cystic carcinomas (6 vulvar and 1 cervical) were identified in patients ranging in age from 27 to 74 years (mean, 48 y; median, 48 y). All of these tumors were characterized by variable p16 expression ranging from very limited to more extensive but never diffuse. No high-risk HPV was detected in any of these pure tumors. Lower female genital tract carcinomas with adenoid cystic differentiation appear to comprise 2 pathogenetically distinct groups. Cervical carcinomas with mixed differentiation, including adenoid cystic, adenoid basal, squamous, and small cell components, are etiologically related to high-risk HPV and can be identified by diffuse p16 expression. Pure vulvar and cervical adenoid cystic carcinomas appear to be unrelated to high-risk HPV and are distinguished from the mixed carcinomas by nondiffuse p16 expression. PMID:26645728

  4. Adenoid cystic carcinoma presenting as an ulcer on the floor of the mouth: a rare case report

    Agwani, Khalid; Bhargava, Puneet; Kumar, Sreeja P.

    2014-01-01

    Adenoid cystic carcinoma is a rare epithelial tumour, and comprises about 1% of all malignant tumours of the oral and maxillofacial region. It is a malignant tumour which may develop in the trachea, bronchus, lungs or mammary glands, in addition to the head and neck region. Occurrences in the head and neck are mostly detected in the major salivary gland, oral cavity, pharynx and paranasal sinus where it presents as a slow growing firm nodular swelling. The aim of the article is to highlight the unique presentation of adenoid cystic carcinoma as a solitary ulcer on the floor of the mouth. PMID:25368840

  5. Primary cutaneous adenoid cystic carcinoma of the eyelid and literature review

    Deniz Turgut Coban; Muhammet Kazim Erol; Dinc Suren; Birsel Tutus

    2015-01-01

    ABSTRACTPrimary cutaneous adenoid cystic carcinoma (PCACC) is a rare malignant epithelial tumor most commonly observed in the scalp and skin of the chest and originating from the palpebral portion of the lacrimal gland in the orbit. Here we describe the diagnosis and treatment of a rare case of PCACC in an eye of a 52-year-old male. The patient presented with a mass lesion of the right lower eyelid. During incisional biopsy, lack of encapsulation and a secretion pattern different to that of c...

  6. Inhibition of STAT3 reduces proliferation and invasion in salivary gland adenoid cystic carcinoma

    Bu, Lin-Lin; Deng, Wei-Wei; Huang, Cong-Fa; Liu, Bing; Zhang, Wen-Feng; SUN, ZHI-JUN

    2015-01-01

    In this study, we accessed the expression and correlation of p-STAT3 with Survivin, Cyclin D1, CD147, Slug and Ki67 by immunohistochemical staining of human tissue microarray which contains 72 adenoid cystic carcinoma (AdCC), 12 pleomorphic adenoma (PMA) and 18 normal salivary gland (NSG) using digital pathological scanner and scoring system. We found that the expression of p-STAT3, Survivin, Slug, Cyclin D1 and CD147 was significantly increased in AdCC as compared with PMA and (or) NSG (p0.0...

  7. Le carcinome urothélial plasmocytoïde de la vessie : une entité histologique rare au pronostic sombre

    Benazzouz, Mohamed Hicham; Essatara, Younes; Elsayegh, Hachem; Iken, Ali; Benslimane, Lounis; Znati, Kaoutar; Nouini, Yassine

    2014-01-01

    Résumé Introduction : Le carcinome urothélial plasmocytoïde est une variante histologique rare du carcinome urothélial. Seule une centaine de cas ont été décrits dans la littérature. Dans cette étude, nous faisons état de deux nouvelles observations. En combinant nos résultats à ceux des différentes séries décrites dans la littérature, nous tentons de définir les caractéristiques cliniques et pathologiques ainsi que l’approche thérapeutique de cette pathologie. Observations : Deux nouveaux cas de carcinome urothélial plasmocytoïde ont été diagnostiqués et pris en charge dans notre établissement. Les 2 patients étaient des hommes de 76 ans en moyenne. L’hématurie était le principal symptôme. Les deux patients ont subi une résection transurétrale de la vessie. Le stade tumoral au moment du diagnostic était avancé dans les deux cas (respectivement T3N0M0 et T3N1M0). Les deux patients ont été traités par cystoprostatectomie. L’analyse histologique de la pièce opératoire, complétée par une étude immunohistochimique, a confirmé le diagnostic de carcinome urothélial plasmocytoïde. Le premier patient est décédé un mois plus tard des suites d’une embolie pulmonaire. Le deuxième patient est décédé au bout de deux mois après avoir reçu deux cycles de chimiothérapie adjuvante. Les données recueillies sur les différentes séries décrites dans la littérature vont dans le même sens que nos données, à savoir un stade avancé au moment du diagnostic et un pronostic sombre. Conclusion : Le carcinome urothélial plasmocytoïde est une variante histologique rare et agressive du carcinome urothélial. Le diagnostic se fait souvent à un stade avancé, et le pronostic est peu encourageant. Le traitement repose le plus souvent sur une cystectomie, suivie d’une chimiothérapie adjuvante à base de cisplatine. L’intérêt d’une chimiothérapie néo-adjuvante n’a pas encore été établi. PMID:25408815

  8. Adjuvant Radiotherapy with Three-Dimensional Conformal Radiotherapy of Lacrimal Gland Adenoid Cystic Carcinoma

    Roshan, Vikas; Mallick, Supriya; Chander, Subhash; Sen, Seema; Chawla, Bhavna

    2015-01-01

    Background & Aim Adenoid cystic carcinoma (ACC) of lacrimal gland is a rare tumour with aggressive behaviour. There is sparse data to address optimum therapy for such tumours. So, the present study was aimed at evaluating the role of adjuvant three dimensional conformal radiotherapy (3D-CRT) in cases of incomplete (R1) resection along with review of literature pertaining to management of lacrimal adenoid cystic carcinoma Materials and Methods We retrospectively reviewed the demographic and treatment data of 10 biopsy proven ACC of lacrimal gland patients, treated from December 2006 to June 2013. They were treated with radiotherapy following surgical resection. Eight patients underwent gross total excision of the tumour mass (enbloc excision) followed by conformal radiotherapy to a dose of 60 Gray/30fractions/ 6 weeks. Two patients with advanced disease were treated with palliative radiotherapy after biopsy. Results The median age was 32 years. There were equal numbers of male and female patients. The median duration of symptoms was 7 months. At a median follow up of 21 months, eight patients had no evidence of disease and had complete tumour response, two patients worsened, and one of the two had systemic failure with bone metastasis. Conclusion Despite a small sample size and short follow, enbloc surgical excision with adjuvant radiotherapy is well tolerated and shows good control in ACC of lacrimal gland. PMID:26557600

  9. Cervico-facial adenoid cystic carcinoma: study of 102 cases. Influence of radiation therapy.

    Miglianico, L; Eschwege, F; Marandas, P; Wibault, P

    1987-05-01

    One hundred two patients with cervico-facial adenoid cystic carcinoma were treated with surgery alone, radiotherapy alone or both from 1951 to 1980. All the cases have a 5-year minimum follow-up. The local control rate is 55.5% at 5 years and 37.7% at 10 years. The 5-year local control rate is 44% with surgery alone, 65.8% with radiotherapy alone and 77.8% with post-operative radiotherapy. The difference between surgery alone and radiosurgical association is significant (p less than 0.01). The bone involvement diminished local control rate (32.2%/k 68.8%). The 5-year survival rate of the patients who recurred and have been retreated is 70.5%. The 5-year survival rate of the patients after the appearance of a metastasis is 38.1% and 2 patients have survived more than 10 years. The NED 5-year survival rate is 48.8%. There is no significant difference in the NED 5-year survival rate according to sites or treatments. The crude 5-year survival rate is 70%, 51.4% at 10 years and 32.2% at 15 years. Our study shows that adenoid cystic carcinoma have a peculiar and slow evolution. Surgery with post-operative radiotherapy obtains the best local control. These results and the radiosensibility of these lesions allow us to propose an aggressive treatment for the recurrence and the primary tumor of the directly metastatic patients. PMID:3032876

  10. Biological behavior and Treatment of Adenoid Cystic Carcinoma in the Head and Neck

    Biological Behavior and treatment results of 33 patients with Adenoid Cystic Carcinoma (ACC) in the Head and Neck at Yonsei Cancer Center for 10 years between 1971 and 1980 were retrospectively analyzed. Most common, primary site was minor salivary glands such as maxillary sinus, nasal cavity and base of tongue. The typical biological behavior of these tumors was very slowly in growth with long rime of duration (mean 19 months) from I month to 10 years and more frequent of nerve invasion but rare invasion of neck nodes. Local control and failure pattern in the results of treatment, 16 of 17 patients with irradiation alone were seen complete or partial response but 5 cases of loco regional recurrence, 2 cases of failure of neck node and 4 cases of distant metastasis as lung and brain. On the other hand, among 10 cases of surgery and postoperative irradiation, 2 cases of locoreginal failure and 3 cases of distant metastasis as lung and bone. 2 of 4 cases with surgery alone were recurred within primary site. Actuarial overall NED survival at 5 and 10 years were 52.6% and 42.8%, respectively. Survival rate of 10 patients with surgery and postoperative irradiation was more high than 17 patients of radiation alone. Therefore, we have known that surgery with postoperative adjunctive irradiation is most effective treatment modality of adenoid cystic carcinoma in the head and neck. Primary site, treatment modality and with or without nerve and bone invasion have influenced on prognosis

  11. Clinicopathological study of 54 cases of adenoid cystic carcinoma in the head and neck

    A retrospective analysis was performed on 54 patients with adenoid cystic carcinoma in the head and neck, treated from January 1971 to July l997 in the Kurume University Hospital. The patients consisted of 35 females and 19 males, with a mean age of 59 years. The site of the lesion was the oral cavity in 13, nasal cavity in 11, submandibular gland in 8, parotid gland in 5, paranasal sinus in 3, nasopharynx in 3, oropharynx in 3, external auditory canal in 3, orbita in 2, lip in 1, lacrimal gland in 1 and trachea in 1. The over all 5-year, 10-year and 15-year survival rates as determined by the Kaplan-Meier method were 72%, 53%, and 46%, respectively. There was no relationship between survival rate and the site of the original lesion. According to the histologic criteria reported by Szanto et al., when more than 30% of the neoplasma showed a solid pattern, its treatment outcome appeared poor. In this study, the same tendency was seen. Fifteen patients died of the tumor. Ten died of distant metastasis and 5 died of local recurrence invading the cranium. No patient died of neck metastasis. Adenoid cystic carcinoma was thought to be radioresistant, but recently some authors have reported this tumor as radiosensitive. This study also showed that postoperative radiotherapy was effective, producing an increase in the survival rate. (author)

  12. Intra-Adenoid Cyst: A Case Report with an Immunohistochemical Study and Review of Literature.

    Matsumoto, Yuma; Yokoi, Hidenori; Ikeda, Tetsuya; Fujiwara, Masachika; Kamma, Hiroshi; Kohno, Naoyuki

    2015-01-01

    A woman in her 50s was referred to our department with the chief complaint of nasal congestion and pharyngeal discomfort. The patient had been diagnosed with sleep apnea at the Department of Internal Medicine, and had undergone nasal continuous positive airway pressure (nCPAP) therapy, but her response to the treatment was poor. A cystic lesion occupying the nasopharynx, which was detected by nasopharyngeal fiberscopy, computed tomography, and magnetic resonance imaging, was thought to be the cause of the nasal congestion, pharyngeal discomfort, and obstructive sleep apnea syndrome (OSAS). Consequently, the patient underwent extirpation of the lesion under general anesthesia for the purpose of obtaining a definitive diagnosis as well as for treatment of the nasopharyngeal tumor. The diagnosis of intra-adenoid cyst was eventually made based on the pathological findings, which revealed lymphoid tissue accompanied by expansion of the crypt, as well as inflammatory cell infiltration with follicular hyperplasia. After the operation, the patient reported subjective improvement of her symptoms, and began to respond to the nCPAP therapy for her sleep apnea syndrome. Nasopharyngeal cysts, in particular adult intra-adenoid cyst, are relatively rare. The outcomes of the current case indicated that the presence of a nasopharyngeal cystic disease was hampering the nCPAP treatment of refractory OSAS. PMID:26056506

  13. Incidence of cervical lymph node metastasis and its association with outcomes in patients with adenoid cystic carcinoma

    Amit, Moran; Binenbaum, Yoav; Sharma, Kanika; Ramer, Naomi; Ramer, Ilana; Agbetoba, Abib; Glick, Joelle; Yang, Xinjie; Lei, Delin; Bjørndal, Kristine; Godballe, Christian; Mücke, Thomas; Wolff, Klaus-Dietrich; Fliss, Dan; Eckardt, André M; Copelli, Chiara; Sesenna, Enrico; Palmer, Frank; Ganly, Ian; Patel, Snehal; Gil, Ziv

    2015-01-01

    BACKGROUND: The patterns of regional metastasis in adenoid cystic carcinoma (ACC) of the head and neck and its association with outcome is not established. METHODS: We conducted a retrospective multicentered multivariate analysis of 270 patients who underwent neck dissection. RESULTS: The incidence...

  14. Analysis of failure in patients with adenoid cystic carcinoma of the head and neck an international collaborative study

    Amit, Moran; Binenbaum, Yoav; Sharma, Kanika; Naomi D, Ramer; Ilana, Ramer; Abib, Agbetoba; Miles, Brett; Yang, Xinjie; Lei, Delin; Bjørndal, Kristine; Godballe, Christian; Thomas, Mücke; Klaus-Dietrich, Wolff; Fliss, Dan; Eckardt, André M; Chiara, Copelli; Sesenna, Enrico; Frank, Palmer; Patel, Snehal; Gil, Ziv

    2014-01-01

    BACKGROUND Adenoid cystic carcinoma (ACC) is a locally aggressive tumor with a high prevalence of distant metastases. The current study aimed to identify independent predictors of outcome and to characterize the patterns of failure. METHODS: An international retrospective review of 489 ACC patients...

  15. Incidence du carcinome hpatocellulaire lors de l'infection chronique par le virus de l'hpatite B

    Ntagirabiri, Rnovat; Munezero, Blyse; Kaze, Hippolyte; Ndirahisha, Eugne; Manirakiza, Sbastien

    2015-01-01

    Introduction Le virus de l'hpatite B (VHB) est incrimin comme cause de cancer primitif du foie. Le stade de fibrose et d'autres facteurs environnementaux et gntiques seraient intriqus. Le but de notre travail tait de dterminer l'incidence du carcinome hpatocellulaire (CHC) lors d'une infection chronique par le VHB et estimer le risque relatif (RR) de CHC li au stade de la fibrose hpatique. Mthodes tude prospective de suivi d'une cohorte de patients porteurs chroniques du VHB sur une priode de 5 ans (2009 2014). Etaient inclus les patients conscutifs qui ont subi un dosage de la charge virale B, une valuation de la fibrose hpatique et un suivi rgulier de tous les 6 12 mois par une chographie hpatique. Rsultats Au total 194 patients ont t retenus. Lge moyen tait de 39,1 ans. Parmi eux 112 taient des hommes. L'incidence cumule de CHC a t de 8,8% dans la population dtude soit une incidence annuelle de 1,8%. Selon le stade de fibrose, 31 patients avaient une fibrose svre ou une cirrhose (score Fibrotest >0,73). Parmi eux, l'incidence cumule de CHC tait de 35,5% soit une incidence annuelle estime 7,10%. Parmi 163 patients ayant une fibrose mineure, l'incidence cumule de CHC tait de 3,7% soit une incidence annuelle de 0,7%. Le RR li la cirrhose tait de 9,7; IC 95%: (3,8-24,1%). Conclusion Le VHB expose au CHC jusqu 10 fois. La fibrose svre et la cirrhose constituent des facteurs prdictifs de CHC chez le porteur chronique du VHB. Evaluer systmatiquement la fibrose pour traiter prcocement les malades pourra prvenir lvolution vers la cirrhose et par l rduire la survenue du CHC. PMID:26113910

  16. Radiotherapy for advanced adenoid cystic carcinoma: neutrons, photons or mixed beam?

    Purpose: To compare retrospectively radiotherapy with neutrons, photons, and a photon/neutron mixed beam in patients with advanced adenoid cystic carcinoma of the head and neck. Local control, survival, distant failure, and complications were analyzed. Materials and methods: Between 1983 and 1995, 75 patients with inoperable, recurrent, or incompletely resected adenoid cystic carcinoma of the head and neck received radiotherapy that consisted of either fast 14.1 MV DT neutrons (median dose 16 neutron Gy), linac-based photon irradiation (median dose 64 photon Gy), or both (median dose 8 neutron Gy and 32 photon Gy). Follow-up ranged from 1 to 160 months (median 51 months), and the surviving patients had a minimum follow-up of 3 years at the time of analysis. Results: The actuarial 5-year local control was 75% for neutrons, and 32% for both mixed beam and photons (P=0.015, log-rank). This advantage for neutrons in local control was not transferred to significant differences in survival (P>0.1). The survival is dictated by the tumor diseases due to distant metastases occurring in 29 (39%) of the 75 patients. Positive lymph nodes were the only significant factor (P=0.001) associated with the development of distant metastases although negative lymph nodes did not predict absence of distant metastases, but predicted a delay of occurrence. In multivariate analysis postoperative radiotherapy (P=0.003) and small tumor size (P=0.01) were associated with high local control, while primary therapy (P=0.006) and negative lymph nodes (P=0.01) were associated with longer survival. While acute toxicity was similar in all three radiotherapy groups, severe late grade 3 and 4 toxicity tended to be more prevalent (P>0.1) with neutrons (19%) than with mixed beam (10%) and photons (4%). Conclusion: Fast neutron radiotherapy provides higher local control rates than a mixed beam and photons in advanced, recurrent or not completely resected adenoid cystic carcinoma of the major and minor salivary glands. Neutron radiotherapy can be recommended in patients with bad prognosis with gross residual disease (R2), with unresectable tumors, or inoperable tumors. The type of radiation does not impact survival, which is dominated by the high number of distant metastases

  17. Primary cutaneous adenoid cystic carcinoma of the eyelid and literature review.

    Coban, Deniz Turgut; Erol, Muhammet Kazim; Suren, Dinc; Tutus, Birsel

    2015-01-01

    Primary cutaneous adenoid cystic carcinoma (PCACC) is a rare malignant epithelial tumor most commonly observed in the scalp and skin of the chest and originating from the palpebral portion of the lacrimal gland in the orbit. Here we describe the diagnosis and treatment of a rare case of PCACC in an eye of a 52-year-old male. The patient presented with a mass lesion of the right lower eyelid. During incisional biopsy, lack of encapsulation and a secretion pattern different to that of chalazion was observed, which differentiated the lesion from chalazion. Pathological analysis revealed the diagnosis of PCACC. This case highlights the importance of careful inspection for macroscopic differentiation of PCACC from chalazion after initial surgery and pathological evaluation of all surgically removed mass lesions for accurate diagnosis and treatment. PMID:26466235

  18. Primary cutaneous adenoid cystic carcinoma of the eyelid and literature review

    Deniz Turgut Coban

    2015-10-01

    Full Text Available ABSTRACTPrimary cutaneous adenoid cystic carcinoma (PCACC is a rare malignant epithelial tumor most commonly observed in the scalp and skin of the chest and originating from the palpebral portion of the lacrimal gland in the orbit. Here we describe the diagnosis and treatment of a rare case of PCACC in an eye of a 52-year-old male. The patient presented with a mass lesion of the right lower eyelid. During incisional biopsy, lack of encapsulation and a secretion pattern different to that of chalazion was observed, which differentiated the lesion from chalazion. Pathological analysis revealed the diagnosis of PCACC. This case highlights the importance of careful inspection for macroscopic differentiation of PCACC from chalazion after initial surgery and pathological evaluation of all surgically removed mass lesions for accurate diagnosis and treatment.

  19. Extradural Spinal Metastasis of Adenoid Cystic Carcinoma (ACC): A Case Report

    Nair, Rajesh; Upadhyaya, Sunil; Nayal, Bhavna; Shetty, Arjun

    2015-01-01

    Adenoid cystic carcinoma (ACC) is a rare malignant tumour of the major salivary glands. It accounts for 10-15% of all salivary gland tumours and 1% of all head and neck tumours. Surgical resection followed by radiation is the choice of treatment for ACC. However, late loco-regional recurrence and metastasis is often seen emphasizing the importance of long-term follow-up. We report an unusual case of extradural metastasis of ACC in the dorsal spine. The primary submandibular gland tumour was resected 11 y back. A recurrence had been detected two years prior to the occurrence of spinal metastasis. Surgical decompression was done which was followed by palliative radiotherapy. Patient is symptomatically better, ambulant and on regular follow-up. PMID:25738073

  20. Bilateral Testicular Metastases of Adenoid Cystic Variant of Carcinoma of Prostate

    Anita AM,

    2014-07-01

    Full Text Available Prostate cancer is the second most frequently diagnosed cancer in men (13.6% and the fifth most common cancer globally. Common sites of prostate carcinoma metastasis other than lymph nodes, include bones, lungs, urinary bladder, liver and adrenal glands. Rarely, a testicular mass, whether painful or painless, represents a metastasis. Metastasis in testes accounts for 0.06-2.5%. Bilateral testicular metastasis is less common and occurs in about 15% of cases. We report a case of prostatic adenocarcinoma in a 65 year male with metastasis to both testes identified upon histopathological examination of therapeutic orchidectomy specimen. Unusual adenoid cystic pattern seen in the metastatic deposits is highlighted. Bilateral metastasis is extremely rare and few are reported in literature

  1. Adenoid cystic carcinoma: A rare late presentation of the mobile tongue

    Kumar, Sanjay; Agarwal, Padmanidhi; Nimmi, V.

    2016-01-01

    Adenoid cystic carcinoma (ACC) is an infrequent malignant neoplasm of the salivary glands. We present a case of a 70-year-old male patient with a swelling over the dorsal and ventral surface of anterior two third of the tongue which was causing him difficulty in mastication since 10 months. Ultrasound and magnetic resonance imaging were done following which the surgical excision of the lesion was performed and histopathological diagnosis of ACC was achieved. It was rare to find ACC in such an old man with such a large lesion presenting so late in the rare site of the mobile tongue. ACC is a slowly growing, highly invasive cancer with a high recurrence rate and chances of metastases, so surgery is the choice of treatment with mandatory long-term follow-up. PMID:27195216

  2. Identification of acid-sensing ion channels in adenoid cystic carcinomas

    Tissue acidosis is an important feature of tumor. The response of adenoid cystic carcinoma (ACC) cells to acidic solution was studied using whole-cell patch-clamp recording in the current study. An inward, amiloride-sensitive Na+ current was identified in cultured ACC-2 cells while not in normal human salivary gland epithelial cells. Electrophysiological and pharmacological properties of the currents suggest that heteromeric acid-sensing ion channels (ASICs) containing 2a and 3 may be responsible for the proton-induced currents in the majority of ACC-2 cells. Consistent with it, analyses of RT-PCR and Western blotting demonstrated the presences of ASIC2a and 3 in ACC-2 cells. Furthermore, we observed the enhanced expression of ASIC2a and 3 in the sample of ACC tissues. These results indicate that the functional expression of ASICs is characteristic feature of ACC cells

  3. Nasal Mucociliary Clearance in Adenoid Hypertrophy and Otitis Media with Effusion.

    Yazıcı, Hasmet

    2015-12-01

    Mucociliary clearance (MCC), which exists in many systems, is the first defensive mechanism of the human body. Nasal MCC has an important role in transporting the secretions of the nasal cavity and paranasal sinuses along with the trapped inhaled pathogens to the nasopharynx. Physiologic or pathologic situations that effect nasal MCC, such as temperature, humidity, nasal obstruction, allergic rhinitis, chronic infections, etc., lead to impaired MCC and related local or circumjacent system disorders. With this perspective, when a unified airway with a multiple disease principle is considered, investigating the relationship between adenoid hypertrophy (AH), otitis media with effusion (OME) and nasal MCC is logical. In this review, histological and physiologic properties of nasal MCC and its possible role involving pathologic situations such as AH and OME is discussed together with recent literature findings. PMID:26496764

  4. Radiologic and pathological correlation of adenoid cystic carcinoma of the breast; A case report

    Kim, Jung Gyu; Kim, Shin Young; Jung, Hae Yoen; Kim, Sung Yong; Lee, Deuk Young; Park, Sang Hyun [Soonchunhyang University College of Medicine, Cheonan Hospital, Cheonan (Korea, Republic of); Park, Sang Hyun [Dept. of Radiology, Plus Internal Medicine Clinic, Suncheon (Korea, Republic of)

    2015-06-15

    Adenoid cystic carcinoma (ACC) is a subtype of adenocarcinoma that is usually seen in the salivary glands. It has also been reported in other organs including the breast, skin, tracheobronchial tree, cervix, larynx, and Bartholin gland. ACC in the breast is rare, accounting for less than 0.1% of all breast cancers. Furthermore, the imaging characteristics of ACC of the breast have not been well described in the literature, especially regarding the findings with magnetic resonance imaging (MRI). Here, we report radiologic findings of a rare case of ACC in the breast by mammography, sonography, computed tomography (CT), positron emission tomography/CT, and MRI with pathologic correlation and a review of the literature.

  5. Adenoid cystic carcinoma in the maxillary gingiva: a case report and immunohistochemical study

    Chi Zhao

    2013-03-01

    Full Text Available Gingival adenoid cystic carcinoma (ACC is a rare malignancy. We describe the diagnosis and treatment of a 43 year-old woman who presented with a persistent oral ulcer for approximately 1 year, and subsequent pain in the left posterior maxillary region. Clinical examination revealed an ulcer in the left upper molar gingiva, with swelling in the region from the second premolar to the third molar. X-ray images demonstrated the involvement of the maxillary alveolar bone. The histopathological and immunohistochemical features were diagnostic of ACC. ACC is often presented as a gingival lesion; thus, it may easily be neglected by patients. The identification of this tumor using specific pathological analyses prevents misdiagnosis and enables clinicians to determine the appropriate treatment. In this case, no recurrence or distant metastasis was observed after 2 years of follow-up.

  6. A subset of prostatic basal cell carcinomas harbor the MYB rearrangement of adenoid cystic carcinoma.

    Bishop, Justin A; Yonescu, Raluca; Epstein, Jonathan I; Westra, William H

    2015-08-01

    Adenoid cystic carcinoma (ACC) is a basaloid tumor consisting of myoepithelial and ductal cells typically arranged in a cribriform pattern. Adenoid cystic carcinoma is generally regarded as a form of salivary gland carcinoma, but it can arise from sites unassociated with salivary tissue. A rare form of prostate carcinoma exhibits ACC-like features; it is no longer regarded as a true ACC but rather as prostatic basal cell carcinoma (PBCC) and within the spectrum of basaloid prostatic proliferations. True ACCs often harbor MYB translocations resulting in the MYB-NFIB fusion protein. MYB analysis could clarify the true nature of prostatic carcinomas that exhibit ACC features and thus help refine the classification of prostatic basaloid proliferations. Twelve PBCCs were identified from the pathology consultation files of Johns Hopkins Hospital. The histopathologic features were reviewed, and break-apart fluorescence in situ hybridization for MYB was performed. All 12 cases exhibited prominent basaloid histology. Four were purely solid, 7 exhibited a cribriform pattern reminiscent of salivary ACC, and 1 had a mixed pattern. The MYB rearrangement was detected in 2 (29%) of 7 ACC-like carcinomas but in none (0%) of the 5 PBCCs with a prominent solid pattern. True ACCs can arise in the prostate as is evidenced by the presence of the characteristic MYB rearrangement. When dealing with malignant basaloid proliferations in the prostate, recommendations to consolidate ACCs with other tumor types may need to be reassessed, particularly in light of the rapidly advancing field of biologic therapy where the identification of tumor-specific genetic alterations presents novel therapeutic targets. PMID:26089205

  7. Expression of ERBB3 binding protein 1 (EBP1) in salivary adenoid cystic carcinoma and its clinicopathological relevance

    ERBB3 binding protein 1 (EBP1) gene transfer into human salivary adenoid cystic carcinoma cells has been shown to significantly inhibit cell proliferation and reduce tumor metastasis in mouse models. In the current study, to evaluate if EBP1 is a novel biomarker capable of identifying patients at higher risk of disease progression and recurrence, we examined the EBP1 expression profile in adenoid cystic carcinoma (ACC) patients and analyzed its clinicopathological relevance. To understand the underlying anti-metastatic mechanism, we investigated if EBP1 regulates invasion-related molecules. We performed immunohistochemical analysis on 132 primary adenoid cystic carcinoma and adjacent non-cancerous tissues using commercial EBP1, MMP9, E-cadherin and ICAM-1 antibodies. Results were correlated to clinicopathological parameters, long-term survival and invasion-related molecules by statistical analysis. Cell motility and invasiveness of vector or wild-type EBP1-transfected ACC-M cell lines were evaluated using wound healing and Boyden chamber assays. MMP9, E-cadherin and ICAM-1 proteins in these cell lines were detected using western blot assay. The expression of EBP1 was significantly higher in non-cancerous adjacent tissues compared with corresponding cancer tissues. The intensity and percentage of cells that reacted with EBP1 antibodies were significantly higher in cases with tubular pattern than those with solid pattern (P<0.0001). We also found adenoid cystic carcinoma with local lymphatic metastasis had significantly lower EBP1 expression than ACC with no local lymphatic node metastasis (P<0.0001). Similar findings were observed in ACC with lung metastasis compared with cases with no lung metastasis (P<0.0001), in particular, in cases with perineural invasion compared with cases with no perineural invasion (P<0.0001). Furthermore, a decrease in EBP1 expression was positively associated with a reduction in overall survival of ACC patients. Of note, EBP1 inhibits migration and invasiveness of ACC cells by upregulating E-cadherin but downregulating MMP9. In clinical adenoid cystic carcinoma patients, higher EBP1 expression was positively correlated with E-cadherin levels (P<0.001) but negatively correlated with MMP9 expression (P=0.0002). EBP1 expression is reduced in adenoid cystic carcinoma, indicating unfavorable prognosis of ACC patients. Its regulation of MMP9 and E-cadherin protein levels suggests a critical therapeutic potential

  8. Reprodutibilidade dos métodos radiográficos para avaliação da adenoide Reliability of radiographic parameters in adenoid evaluation

    Murilo Fernando Neuppmann Feres

    2012-08-01

    Full Text Available Embora a avaliação radiográfica da hipertrofia de tonsila faríngea tenha sido constantemente debatida, há ainda carência de estudos que testem a confiabilidade da maioria dos parâmetros radiográficos existentes. OBJETIVO: Verificar a reprodutibilidade intra e interexaminadores de vários métodos destinados à avaliação da tonsila faríngea. Forma de estudo: Estudo de série, metodológico e transversal. MATERIAL E MÉTODO: Quarenta crianças de ambos os sexos, de 4 a 14 anos, foram selecionadas mediante apresentação de queixas de obstrução nasal ou respiração oral, com suspeita de diagnóstico de hipertrofia de tonsila faríngea. Radiografias do cavum faríngeo e telerradiografias ortodônticas foram obtidas e, posteriormente, avaliadas por dois examinadores por meio de instrumentos de avaliação quantitativos e categóricos. RESULTADOS: Todos os parâmetros quantitativos de ambas as modalidades radiográficas apresentaram excelente reprodutibilidade intra e interexaminadores. Dentre os parâmetros categóricos de avaliação da radiografia de cavum, observou-se desempenho relativamente melhor de C-Kurien, C-Wang, C-Fujioka e C-Elwany sobre C-Cohen e C-Ysunza. Em relação aos sistemas destinados à classificação da telerradiografia, C-McNamara apresentou maior reprodutibilidade que C-Holmberg. CONCLUSÃO: A maioria dos instrumentos apresentou reprodutibilidade adequada. No entanto, novas investigações ainda devem ser realizadas com o intuito de determinar a capacidade de cada parâmetro em relação sua acurácia e viabilidade.The assessment of adenoids by x-ray imaging has been the topic of heated debate, but few studies have looked into the reliability of most existing radiographic parameters. OBJECTIVE: This study aims to verify the intra-examiner and inter-examiner reproducibility of the adenoid radiographic assessment methods. MATERIALS AND METHODS: This is a cross-sectional case series study. Forty children of both genders aged between 4 and 14 were enrolled. They were selected based on complaints of nasal obstruction or mouth breathing and suspicion of pharyngeal tonsil hypertrophy. Cavum x-rays and orthodontic teleradiographs were assessed by two examiners in quantitative and categorical terms. RESULTS: All quantitative parameters in both x-ray modes showed excellent intra and inter-examiner reproducibility. Relatively better performance was observed in categorical parameters used in cavum x-ray assessment by C-Kurien, C-Wang, C-Fujioka, and C-Elwany over C-Cohen and C-Ysunza. As for orthodontic teleradiograph grading systems, C-McNamara has been proven to be more reliable than C-Holmberg. CONCLUSION: Most instruments showed adequate reproducibility levels. However, more research is needed to properly determine the accuracy and viability of each method.

  9. Expression of ERBB3 binding protein 1 (EBP1 in salivary adenoid cystic carcinoma and its clinicopathological relevance

    Sun Jian

    2012-10-01

    Full Text Available Abstract Background ERBB3 binding protein 1 (EBP1 gene transfer into human salivary adenoid cystic carcinoma cells has been shown to significantly inhibit cell proliferation and reduce tumor metastasis in mouse models. In the current study, to evaluate if EBP1 is a novel biomarker capable of identifying patients at higher risk of disease progression and recurrence, we examined the EBP1 expression profile in adenoid cystic carcinoma (ACC patients and analyzed its clinicopathological relevance. To understand the underlying anti-metastatic mechanism, we investigated if EBP1 regulates invasion-related molecules. Methods We performed immunohistochemical analysis on 132 primary adenoid cystic carcinoma and adjacent non-cancerous tissues using commercial EBP1, MMP9, E-cadherin and ICAM-1 antibodies. Results were correlated to clinicopathological parameters, long-term survival and invasion-related molecules by statistical analysis. Cell motility and invasiveness of vector or wild-type EBP1-transfected ACC-M cell lines were evaluated using wound healing and Boyden chamber assays. MMP9, E-cadherin and ICAM-1 proteins in these cell lines were detected using western blot assay. Results The expression of EBP1 was significantly higher in non-cancerous adjacent tissues compared with corresponding cancer tissues. The intensity and percentage of cells that reacted with EBP1 antibodies were significantly higher in cases with tubular pattern than those with solid pattern (PPPPPP=0.0002. Conclusions EBP1 expression is reduced in adenoid cystic carcinoma, indicating unfavorable prognosis of ACC patients. Its regulation of MMP9 and E-cadherin protein levels suggests a critical therapeutic potential.

  10. Imaging appearance of a singular metastatic adenoid cystic carcinoma of the right kidney: A case report and literature review

    QIU, DA-SHENG; XU, LI-YING; HU, XIAO-YAN

    2014-01-01

    Renal metastasis of a submandibular gland adenoid cystic carcinoma is clinically rare when it presents with an atypical imaging appearance of singular renal metastases. Whole-body positron emission tomography (PET)/computed tomography (CT) can determine whether the singular renal mass is benign or malignant and identify metastases in other parts of the body, particularly in uncommon sites. In the present case, the patient developed a rare partial metastasis to the right kidney three years aft...

  11. A case of transient cortical blindness associated with hypercapnia as a result of extremely enlarged adenoid tissue.

    Malbora, Baris; Malbora, Nihan; Avci, Zekai; Olgac, Asburce; Erkan, Alper Nabi

    2015-01-01

    Adenotonsillar hypertrophy is common among children, but it can lead to serious complications if left untreated. Among the well-known complications are obstructive sleep apnea syndrome, growth failure, cor pulmonale, and hypertension. One complication of adenotonsillar hypertrophy that has not been previously reported in the English-language literature is transient cortical blindness. We describe such a case, which occurred in a 6-year-old boy who presented with a sudden loss of vision and subsequent unconsciousness. He had experienced hypercapnia and was resuscitated via endotracheal tube ventilation. Laboratory and radiologic assessments found no pathology except for extremely enlarged adenoid tissue. Once the patient was stabilized, an urgent adenotonsillectomy was performed. The patient recovered well, and his vision and respiratory symptoms resolved. Severe hypertrophy of the adenoid tissue can cause hypercapnia and acidosis secondary to upper airway obstruction. The possibility of adenoid hypertrophy and hypercapnia should be kept in mind in cases of transient cortical blindness. Aggressive treatment, including early intubation and adenoidectomy, may lead to a rapid resolution of symptoms. PMID:25606839

  12. Le carcinome neuro-endocrine cutané primitif: à propos d'un nouveau cas et revue de la littérature

    Boukind, Samira; Elatiqi, Oumkeltoum; Dlimi, Meriem; Elamrani, Driss; Benchamkha, Yassine; Ettalbi, Saloua

    2015-01-01

    Le carcinome neuro- endocrine cutané primitif (CNEC) est une tumeur cutanée rare et agressive du sujet âgé, favorisée par le soleil et l'immunodépression. Elle est caractérisée par une évolution agressive avec un fort taux de récidive, une évolution ganglionnaire régionale et un risque de métastases à distance. Nous rapportons un cas de cette tumeur chez un patient âgé de 67 ans sous forme d'un placard nodulaire hémorragique mesurant 16 /14 cm. Le patient a bénéficié d'une exérèse chirurgical...

  13. Increased percentage of T cells with the expression of CD127 and CD132 in hypertrophic adenoid in children with otitis media with effusion.

    Żelazowska-Rutkowska, Beata; Wysocka, Jolanta; Ratomski, Karol; Kasprzycka, Edwina; Skotnicka, Bożena

    2012-07-01

    The hypertrophic adenoid may promote chronic suppurative otitis media in children as it fulfills its immune function. The number of lymphocytes in the adenoid and their cooperation in the immune response depend of on their proliferation and migration to the effector sites. Interleukin 7 (IL-7) is essential for the normal development and function lymphocytes. IL-7 plays pivotal role for activation and proliferation of T and B cells. The heterodimeric interleukin-7 receptor (IL-7R) is composed of the IL-7Rα (127) and the common cytokine receptor γc (CD132). The aim of this study was to evaluate the percentage of lymphocytes T (CD4(+) and CD8(+)) with IL-7R (CD127 and CD132) expression in hypertrophic adenoid in children suffering with otitis media with effusion for a duration of 3 months. Adenoid excised due to hypertrophy with or without chronic otitis media with effusion was used as study material. CD4(+) CD127(+), CD4(+)132(+), CD8(+)CD127(+) and CD8(+)CD132(+) cell subpopulations were identified using monoclonal antibodies and flow cytometry. The percentage of CD4(+) and CD8(+) T cells with CD127 receptor expression in hypertrophic adenoid of children with otitis media with effusion was statistically significantly higher than in hypertrophic adenoid group. The percentage of CD4(+) T cells with CD132 expression in the study group was statistically significantly higher than in the reference group. The percentage of CD8(+) T cells with CD132(+) expression was not statistically different in both groups. The increased percentage of T lymphocytes with IL-7R expression (CD127 and CD132) in hypertrophic adenoid seems to influence the quantity of lymphocytes and upset the immunological function of tonsils which can influence the course of otitis media with effusion. PMID:22382400

  14. Adenoid and tonsil surgeries in children: How relevant is pre-operative blood grouping and cross-matching?

    Lucky Onotai

    2013-01-01

    Full Text Available Background: As a part of pre-operative evaluation, several otolaryngologists group and cross-match blood routinely for children undergoing adenoid and tonsil surgeries. This practice has generated several debates either in support or against this practice. The aim of this study is to critically evaluate the incidence of post-tonsillectomy (with or without adenoidectomy bleeding and blood transfusions in otherwise healthy children with adenoid/tonsil pathologies conducted in the University of Port Harcourt Teaching Hospital (UPTH. Patients and Methods: A descriptive retrospective study of children who underwent adenoid and tonsil surgeries in the Department of Ear, Nose and Throat (ENT surgery of UPTH from January 2003 to December 2012. Children with family history of bleeding disorders and derangement of clotting profile as well as different co-morbidity like sickle cell disease were excluded from this study. The patients′ data were retrieved from the registers of ENT out-patient clinics, theatre registers and patients case notes. Demographic data, indications for surgery, preoperative investigations, complications and management outcomes were recorded and analyzed. Results: Out of 145 children that had adenoid and tonsil surgeries; only 100 met the criteria for this study. The study subjects included 65 males and 35 females (male: female ratio 1.9:1 belonging to 0-16 years age group (mean age: 3.46 ± 2.82 years. The age group of 3-5 years had the highest (n = 40, 40% number of surgeries. Adenotonsillectomy was the commonest (n = 85, 85% surgery performed on patients who had obstructive sleep apnea (OSA. The commonest (n = 6, 6% complication was haemorrhage, and only few (n = 3, 3% patients had blood transfusion. However, mortality was recorded in some (n = 3, 3% patients. Conclusion: This study confirms that the incidence of post adenoidectomy/tonsillectomy bleeding in otherwise healthy children is low and rarely requires blood transfusion. We can conclude that routine preoperative blood grouping and cross-matching of blood for all children undergoing elective adenoid and tonsil surgeries seemed irrelevant and not cost effective. However, it could be carried out in only special circumstances.

  15. Apigenin inhibits the proliferation of adenoid cystic carcinoma via suppression of glucose transporter-1.

    Fang, Jin; Bao, Yang-Yang; Zhou, Shui-Hong; Fan, Jun

    2015-11-01

    Apigenin is a natural phyto-oestrogen flavonoid, which exerts various biological effects, including anti‑oxidative, anti‑inflammatory and anticancer activities. In addition, apigenin has recently been reported to target hypoxic markers; however, there are currently no studies regarding the association between apigenin and glucose transporter‑1 (GLUT‑1) in adenoid cystic carcinoma (ACC). The present study investigated whether apigenin inhibits the proliferation of ACC cells or suppresses the expression of GLUT‑1 in ACC cells. The results of the present study demonstrated that apigenin inhibits ACC‑2 cell growth in a dose‑ and time‑dependent manner. Treatment with apigenin also induced apoptosis and G2/M‑phase arrest in a dose‑ and time‑dependent manner. Corresponding with the above results, the expression levels of GLUT‑1 were significantly decreased following treatment in a dose- and time-dependent manner. These results suggest that the inhibition of ACC-2 cell growth by apigenin may be due to the decreased expression of GLUT-1. PMID:26300442

  16. Comparison of immunohistochemical markers between adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma.

    Saghravanian, Nasrollah; Mohtasham, Nooshin; Jafarzadeh, Hamid

    2009-12-01

    Adenoid cystic carcinoma (AdCC) and polymorphous low-grade adenocarcinoma (PLGA) have several common histological and clinicopathological features that may create diagnostic difficulties. In this study, 10 AdCCs, 8 PLGAs, and 5 normal minor salivary glands as a control group were selected. Sections prepared from each tumor were stained using the streptavidin-biotin system for seven marker antigens: carcinoembryonic antigen (CEA), epithelial membrane antigen (EMA), muscle-specific actin (MSA), vimentin, S100, p53, and Ki-67. Data analysis showed high expression of CEA, MSA and Ki-67 in AdCCs compared with PLGAs, although CEA expression was limited to luminal cells. Ki-67 was expressed in both luminal and non-luminal cells and MSA only in non-luminal cells. Vimentin and S100 showed stronger expression in PLGAs, the expression of vimentin was more noticeable, being focal and widespread. The immunoreactivities of EMA and P53 were not helpful for distinguishing between the two tumors, although the EMA expression pattern in AdCCs was limited to luminal cells, whereas it was present in both luminal and non-luminal cells in PLGAs. Thus, immunohistochemistry can be helpful for differential diagnosis of AdCC and PLGA, particularly that for CEA, vimentin, and Ki-67. PMID:20032601

  17. Pediatric adenoid cystic carcinoma of the lacrimal gland treated with intra-arterial cytoreductive chemotherapy.

    Eneh, Amaka; Parsa, Kami; Wright, Kenneth W; Strube, Yi Ning J

    2015-06-01

    Adenoid cystic carcinoma (ACC) of the lacrimal gland is the most common primary malignant tumor of the lacrimal gland. It typically affects patients in the fifth decade of life and presents with rapid progression of pain, ptosis, motility disturbances, and sensory deficits of less than 1 year's duration. ACC is rare in children. Due to early, aggressive perineural and bony spread, there is a high risk of intracranial extension. Additionally, due to frequent hematogenous and lymphatic spread, there is a high rate of distant metastases even after treatment, which can occur late up to a decade or more. The currently accepted treatment for ACC is radical exenteration with orbitotomy and adjuvant chemotherapy and/or radiation therapy. Recently, intra-arterial cytoreductive chemotherapy (IACC) has been investigated as a neoadjuvant treatment modality. It has the advantage of increasing local concentration at the target tissue and decreasing systemic distribution. We report the first known pediatric case of ACC treated with IACC, followed by exenteration, radiation, and adjuvant intravenous chemotherapy. The patient was followed for 4 years, with no recurrence and no known complications. PMID:25890838

  18. Nasopharyngeal and Adenoid Colonization by Haemophilus influenzae and Haemophilus parainfluenzae in Children Undergoing Adenoidectomy and the Ability of Bacterial Isolates to Biofilm Production.

    Kosikowska, Urszula; Korona-Głowniak, Izabela; Niedzielski, Artur; Malm, Anna

    2015-05-01

    Haemophili are pathogenic or opportunistic bacteria often colonizing the upper respiratory tract mucosa. The prevalence of Haemophilus influenzae (with serotypes distribution), and H. parainfluenzae in the nasopharynx and/or the adenoid core in children with recurrent pharyngotonsillitis undergoing adenoidectomy was assessed. Haemophili isolates were investigated for their ability to biofilm production.Nasopharyngeal swabs and the adenoid core were collected from 164 children who underwent adenoidectomy (2-5 years old). Bacteria were identified by the standard methods. Serotyping of H. influenzae was performed using polyclonal and monoclonal antisera. Biofilm formation was detected spectrophotometrically using 96-well microplates and 0.1% crystal violet.Ninety seven percent (159/164) children who underwent adenoidectomy were colonized by Haemophilus spp. The adenoid core was colonized in 99.4% (158/159) children, whereas the nasopharynx in 47.2% (75/159) children (P parainfluenzae and 14 isolates of other Haemophilus spp. were selected. In 20.1% (32/159) children 2 or 3 phenotypically different isolates of the same species (H. influenzae or H. parainfluenzae) or serotypes (H. influenzae) were identified in 1 child. 67.2% (129/192) isolates of H. influenzae, 56.3% (54/96) isolates of H. parainfluenzae and 85.7% (12/14) isolates of other Haemophilus spp. were positive for biofilm production. Statistically significant differences (P = 0.0029) among H. parainfluenzae biofilm producers and nonproducers in the adenoid core and the nasopharynx were detected.H. influenzae and H. parainfluenzae carriage rate was comparatively higher in the adenoid core than that in the nasopharynx in children undergoing adenoidectomy, suggesting that their involvement in chronic adenoiditis. The growth in the biofilm seems to be an important feature of haemophili colonizing the upper respiratory tract responsible for their persistence. PMID:25950686

  19. CT diagnosis of adenoid cystic carcinoma of the nasal cavity and paranasal sinus

    Purpose: To assess CT findings and their clinical value in the diagnosis of adenoid cystic carcinoma (ACC) of the nasal cavity and paranasal sinus. Materials and methods: Pre-treatment CT findings in 17 histologically proven cases of ACC of the nasal and paranasal sinus were reviewed. 3 cases had plain CT, 2 cases both pre- and post-contrast enhanced CT, and 12 cases contrast enhanced CT. There were 18 axial and 16 coronal scans. Results: Tumors originated from and localized in the nasal cavity in 2 cases. In 15 cases, tumors were located in maxillary sinus and invaded adjacent organs or/and structures, including ipsilateral ethmoid sinus, sphenoid sinus and nasal cavity, contralateral maxillary sinus, orbit, palate, infratemporal fossa, pterygopalatine fossa, parapharyngeal space, inferior orbital fissure and foramen oval. In 7 cases, lesions invaded intracranial structures as well as the cavernous sinus. Altogether there were 2 cases of stage I, 3 cases stage III, and 12 cases stage IV. Adjacent bony changes were found in 16 cases, with bony remodeling (4 cases) and bony erosion combined with expansion (12) (71%). The diameter of the mass was larger than 5 cm in 71% of the cases. In 41% of the cases, tumors were irregular in shape, mottled pattern of lucencies within the tumor was shown in 82% of cases. Scattered calcification could be identified in 3 cases. Conclusion: Most of ACC of the nasal cavity and paranasal sinus had mottle pattern of lucencies within the tumor, irregular in shape, adjacent bony remodeling and/or erosive destruction. These findings indicate the histologic and biologic characteristics of the tumor with slow growing and perineural invasion. Apart from axial scan, coronal scan and contrast administration are mandated for the diagnosis and staging ACC

  20. Management of Adenoid Cystic Carcinoma of the Breast: A Rare Cancer Network Study

    Khanfir, Kaouthar, E-mail: kaouthar.khanfir@rsv-gnw.ch [Hopital de Sion, CHCVs, Sion (Switzerland); Kallel, Adel [Institut Gustave Roussy, Villejuif (France); Villette, Sylviane [Centre Rene Huguenin, Paris (France); Belkacemi, Yazid [CHU Henri Mondor, Centre Oscar Lambret, Lille (France); Vautravers, Claire [Centre George Francois Leclerc, Dijon (France); Nguyen, TanDat [Institut Jean Gaudinot, Reims (France); Miller, Robert [Mayo Clinic, Rochester, Minnesota (United States); Li Yexiong [Peking Union Medical College, Beijing (China); Taghian, Alphonse G. [Massachusetts General Hospital, Boston, Massachusetts (United States); Boersma, Liesbeth [Maastricht University Medical Center (MAASTRO clinic), Maastricht (Netherlands); Poortmans, Philip [Dr. Bernard Verbeeten Institute, Tilburg (Netherlands); Goldberg, Hadassah [Western Galilee Hospital-Nahariya, Nahariya (Israel); Vees, Hansjorg [Hopitaux Universitaires de Geneve, Geneva (Switzerland); Senkus, Elzbieta [Medical University of Gdansk, Gdansk (Poland); Igdem, Sefik; Ozsahin, Mahmut [Istanbul Bilim University, Istanbul (Turkey); Jeanneret Sozzi, Wendy [Centre Hospitalier Universitaire Vaudois, Lausanne (Switzerland)

    2012-04-01

    Background: Mammary adenoid cystic carcinoma (ACC) is a rare breast cancer. The aim of this retrospective study was to assess prognostic factors and patterns of failure, as well as the role of radiation therapy (RT), in ACC. Methods: Between January 1980 and December 2007, 61 women with breast ACC were treated at participating centers of the Rare Cancer Network. Surgery consisted of lumpectomy in 41 patients and mastectomy in 20 patients. There were 51(84%) stage pN0 and 10 stage cN0 (16%) patients. Postoperative RT was administered to 40 patients (35 after lumpectomy, 5 after mastectomy). Results: With a median follow-up of 79 months (range, 6-285), 5-year overall and disease-free survival rates were 94% (95% confidence interval [CI], 88%-100%) and 82% (95% CI, 71%-93%), respectively. The 5-year locoregional control (LRC) rate was 95% (95% CI, 89%-100%). Axillary lymph node dissection or sentinel node biopsy was performed in 84% of cases. All patients had stage pN0 disease. In univariate analysis, survival was not influenced by the type of surgery or the use of postoperative RT. The 5-year LRC rate was 100% in the mastectomy group versus 93% (95% CI, 83%-100%) in the breast-conserving surgery group, respectively (p = 0.16). For the breast-conserving surgery group, the use of RT significantly correlated with LRC (p = 0.03); the 5-year LRC rates were 95% (95% CI, 86%-100%) for the RT group versus 83% (95% CI, 54%-100%) for the group receiving no RT. No local failures occurred in patients with positive margins, all of whom received postoperative RT. Conclusion: Breast-conserving surgery is the treatment of choice for patients with ACC breast cancer. Axillary lymph node dissection or sentinel node biopsy might not be recommended. Postoperative RT should be proposed in the case of breast-conserving surgery.

  1. A retrospective study of 18 cases of adenoid cystic cancer at a tertiary care centre in Delhi

    K Sharma

    2010-01-01

    Full Text Available Context: Adenoid cystic carcinoma (ACC is a rare neoplasm that usually arises from the salivary, lacrimal, or other exocrine glands. It is characteristically locally infiltrative in nature and has a tendency toward local recurrence, high propensity for perineural invasion, and prolonged clinical course. Aim: To analyze the presentation and natural history of cases of adenoid cystic tumors of salivary glands in our institution; and to compare with the existing literature. Design and Setting: Retrospective study at the Department of Radiotherapy. Materials and Methods: Data on 18 patients of ACC of the salivary glands treated between 2004 and 2008 were reviewed with respect to clinical presentation, stage, and histology. Results: There were 8 cases of major salivary gland tumors (47%, of which 2 were in the submandibular and 6 were involving the parotid. Ten patients (53% had minor salivary gland involvement. Two patients had metastasis at the time of presentation. All patients underwent surgery. Radiotherapy was delivered to 16 patients and chemotherapy to 6 patients (concurrent, n = 3 and adjuvant, n = 3 and no adjuvant therapy was given to 2 patients. All patients were alive at a median follow-up of 3 years. No patient developed local or distant failure during the study duration. Conclusion: ACC has locally aggressive behavior. Radiotherapy adjuvant to surgery improves local control in locally advanced disease. Longer follow-up is mandatory in view of incidence of late metastasis.

  2. Adenoid cystic carcinoma of the skull base: results with an aggressive multidisciplinary approach.

    Ramakrishna, Rohan; Raza, Shaan M; Kupferman, Michael; Hanna, Ehab; DeMonte, Franco

    2016-01-01

    OBJECT Adenoid cystic carcinoma (ACC) is a locally aggressive tumor of salivary gland origin. Little data exist to guide treatment when this tumor extends to involve the structures of the skull base. METHODS Fifty-one patients with a diagnosis of ACC affecting the skull base were identified from a prospective database at MD Anderson Cancer Center (from 1992 to 2010). RESULTS Median follow-up for study patients was 6.75 years. The 5- and 10-year overall survival (OS) rates were 78% and 50%, respectively. Sixty-six percent of patients had progression of their disease. The 5- and 10-year progression-free survival (PFS) rates were 46.7% and 21.0%, respectively. Gross-total resection was achieved in 75% of patients, with 49% having microscopically negative margins at the time of first operation. On univariate analysis, resections with microscopically negative margins were associated with a significant OS advantage (20.1 ± 3.3 years) compared with resections that left residual disease, even if microscopic (10.3 ± 1.6 years, p = 0.035). In patients who underwent reoperation, the effect persisted, with improved OS in those with negative margins (21.4 ± 0.0 vs 16.7 ± 4.0 years, p = 0.06). The use of adjuvant radiotherapy was associated with an OS advantage (16.2 ± 2.5 vs 5.5 ± 2.2 years, p = 0.03) at initial diagnosis and improved PFS (7.8 ± 1.0 vs 2.1 ± 0.62 years, p = 0.005), whereas repeat irradiation provided no benefit. The use of adjuvant chemotherapy at diagnosis or at recurrence was not associated with any significant advantage. Multivariate analysis revealed margin-negative resection at initial operation and at recurrence retained OS significance, even after controlling for age, radiation therapy, and T stage. CONCLUSIONS ACC of the skull base is best treated with a multidisciplinary approach aimed at maximal, safe resection. Adjuvant radiotherapy should be offered, whereas chemotherapy does not confer benefit. PMID:26252456

  3. Prevalence of Panton-Valentine leucocidin and phenotypic and genotypic characterization of biofilm formation among Staphylococcus aureus strains isolated from children with adenoid hypertrophy.

    Emaneini, Mohammad; Khoramrooz, Seyed Sajjad; Shahsavan, Shadi; Dabiri, Hossein; Jabalameli, Fereshteh

    2015-12-01

    Adenoids as a first line of host defense against respiratory microbes play an important role in majority of upper airway infectious and noninfectious illnesses. Bacterial pathogen can colonize on the adenoid tissue and probably act as a reservoir for them. To determine phenotypic and genotypic characterization of biofilm forming capacity of Staphylococcus aureus isolates from children with adenoid hypertrophy and prevalence of Panton-Valentine leukocidin (PVL) gene we collected 17 consecutive, clinically significant S. aureus isolates from children with adenoid hypertrophy undergoing adenoidectomy with one or more of the upper airway obstruction symptoms, nasal obstruction, mouth breathing, snoring, or sleep apnea. Biofilm formation was evaluated by colorimetric microtiter plate's assay. Gene encoding PVL and adhesion- or biofilm formation-encoding genes were targeted by polymerase chain reaction (PCR) assay. According to the results, all strains produced biofilm. Seven (41.2%) isolates produced strong biofilm whereas 7 (41.2%) isolates produced week and 3 (17.6%) isolates produced medium biofilm. Regarding the adhesion- or biofilm formation-encoding genes, 16 (94.1%) isolates were positive for the gene eno, 13(76.4%) for icaA, 13 (76.4%) for icaD, 10 (58.8%) for fib, 10 (58.8%) for fnbB, 4(23.5%) for can, and 1(5.8%) for fnbA. The high prevalence of genes encoding biofilms and adhesins and phenotypic ability to form a biofilm by S. aureus strains emphasizes the pathogenic character of strains isolated from children with adenoid hypertrophy. PMID:26476288

  4. Reliability of adenoid hypertrophy diagnosis by cephalometric radiography / Confiabilidade do diagnstico da hipertrofia das adenides por meio da cefalometria

    Alexandre Jose, RETCHESKI; Nelson Padilha da, SILVA; Fernanda, LEITE; Paulo Roberto Aranha, NOUER.

    2014-09-01

    Full Text Available OBJETIVO: Verificar a confiabilidade do diagnstico da hipertrofia das adenides por meio da cefalometria. MTODOS: Trinta indivduos do gnero masculino, com idades entre 12 e 15 anos, [...] respiradores bucais ou no, foram selecionados e neles realizados exames de diagnstico de hipertrofia da adenide por cefalometria radiolgica, a partir da telerradiografia em norma lateral e exames rinoscpicos, a partir da nasofibroscopia (padro ouro). A cefalometria utilizada foi a computadorizada e para isto se utilizou o programa CefX verso 2000 e a rinoscopia foi realizada com um nasofibroscpio flexvel. Foi tomado como ponto de corte 47% e 75% de bloqueio da nasofaringe para a telerradiografia e nasofibroscopia, respectivamente. RESULTADOS: A correlao encontrada entre os dois exames foi considerada moderadamente positiva (0,5) e os testes de validade e confiabilidade registraram uma sensibilidade de 100%, especificidade de 65,5%, valor preditivo positivo de 9,1%, valor preditivo negativo de 100% e exatido de 66,60%. CONCLUSO: A telerradiografia lateral foi considerada um meio prtico, confortvel para o paciente e relativamente eficiente na deteco da hiperplasia da adenide e na obteno do diagnstico de obstruo nasofaringeana. Abstract in english OBJECTIVE: To verify the reliability of adenoid hypertrophy diagnosis by cephalometric radiography. METHOD: Thirty male subjects, aged between 12 and 15 years, either mouth-breathers, or [...] not, were selected. Diagnostic tests for adenoid hypertrophy were performed by radiological cephalometry based on lateral cephalometric radiographs and nasal endoscopy (gold standard). The CefX Cephalometric software program, version 2000 was used and the rhinoscopy was performed with a flexible endoscope. Blockage of 47% and 75% of the nasopharynx were taken as the cutoff points for cephalometric radiography and endoscopy, respectively. RESULTS: The correlation between the two examinations was considered moderately positive (0.5). Tests of validity and reliability reported a sensitivity of 100%; specificity 65.5%; positive predictive value of 9.1%; negative predictive value 100%, and exactness of 66.60%. CONCLUSION: Lateral cephalometric radiography was considered practical and comfortable for the patient; relatively efficient for detecting adenoid hypertrophy and obtaining the diagnosis of nasopharyngeal airway obstruction.

  5. WIP1 stimulates migration and invasion of salivary adenoid cystic carcinoma by inducing MMP-9 and VEGF-C.

    Tang, Ya-ling; Liu, Xin; Gao, Shi-yu; Feng, Hao; Jiang, Ya-ping; Wang, Sha-sha; Yang, Jing; Jiang, Jian; Ma, Xiang-rui; Tang, Ya-jie; Chen, Yu; Liang, Xin-hua

    2015-04-20

    The wild-type p53 induced phosphatase 1 (WIP1) is an oncogene overexpressed in a variety of human cancers. Here, we demonstrated that WIP1 silencing reduced MMP-9 and VEGF-C expression as well as migration and invasion of salivary adenoid cystic carcinoma (ACC) cells. Overexpression of MMP-9 or VEGF-C restored migration and invasion in WIP1 knockdown cells, indicating that MMP-9 and VEGF-C are downstream targets of WIP1 signaling. Levels of cyclin D1 and c-Myc, targets of Wnt/?-catenin pathway, were significantly decreased by WIP1 silencing. In addition, WIP1 expression was positively associated with metastasis and prognosis of ACC patients as well as with MMP-9 or VEGF-C in ACC tissues. PMID:25797250

  6. An unusual presentation of adenoid cystic carcinoma of the minor salivary glands with cranial nerve palsy: a case study

    Morris Pierre A

    2007-08-01

    Full Text Available Abstract Background Adenoid Cystic Carcinoma (ACC is a rare tumor entity and comprises about 1% of all malignant tumor of the oral and maxillofacial region. It is slow growing but a highly invasive cancer with a high recurrence rate. Intracranial ACC is even more infrequent and could be primary or secondary occurring either by direct invasion, hematogenous spread, or perineural spread. We report the first case of the 5th and 6th nerve palsy due to cavernous sinus invasion by adenoid cystic carcinoma. Case presentation A 49-year-old African American female presented to the emergency room complaining of severe right-sided headache, photophobia, dizziness and nausea, with diplopia. The patient had a 14 year history migraine headaches, hypertension, and mild intermittent asthma. Physical examination revealed right lateral rectus muscle palsy with esotropia. There was numbness in all three divisions of the right trigeminal nerve. Motor and sensory examination of extremities was normal. An MRI of the brain/brain stem was obtained which showed a large mass in the clivus extending to involve the nasopharynx, pterygoid plate, sphenoid and right cavernous sinuses. Biopsy showed an ACC tumor with a cribriform pattern of the minor salivary glands. The patient underwent total gross surgical resection and radiation therapy. Conclusion This is a case of ACC of the minor salivary glands with intracranial invasion. The patient had long history of headaches which changed in character during the past year, and symptoms of acute 5th and 6th cranial nerve involvement. Our unique case demonstrates direct invasion of cavernous sinus and could explain the 5th and 6th cranial nerve involvement as histopathology revealed no perineural invasion.

  7. An unusual presentation of adenoid cystic carcinoma of the minor salivary glands with cranial nerve palsy: a case study

    Adenoid Cystic Carcinoma (ACC) is a rare tumor entity and comprises about 1% of all malignant tumor of the oral and maxillofacial region. It is slow growing but a highly invasive cancer with a high recurrence rate. Intracranial ACC is even more infrequent and could be primary or secondary occurring either by direct invasion, hematogenous spread, or perineural spread. We report the first case of the 5th and 6th nerve palsy due to cavernous sinus invasion by adenoid cystic carcinoma. A 49-year-old African American female presented to the emergency room complaining of severe right-sided headache, photophobia, dizziness and nausea, with diplopia. The patient had a 14 year history migraine headaches, hypertension, and mild intermittent asthma. Physical examination revealed right lateral rectus muscle palsy with esotropia. There was numbness in all three divisions of the right trigeminal nerve. Motor and sensory examination of extremities was normal. An MRI of the brain/brain stem was obtained which showed a large mass in the clivus extending to involve the nasopharynx, pterygoid plate, sphenoid and right cavernous sinuses. Biopsy showed an ACC tumor with a cribriform pattern of the minor salivary glands. The patient underwent total gross surgical resection and radiation therapy. This is a case of ACC of the minor salivary glands with intracranial invasion. The patient had long history of headaches which changed in character during the past year, and symptoms of acute 5th and 6th cranial nerve involvement. Our unique case demonstrates direct invasion of cavernous sinus and could explain the 5th and 6th cranial nerve involvement as histopathology revealed no perineural invasion

  8. Effects of 5-aza-2′deoxycytidine on RECK gene expression and tumor invasion in salivary adenoid cystic carcinoma

    Zhou, X.Q. [Department of Oral and Maxillofacial Surgery, School of Stomatology, Shandong University, Jinan (China); Department of Oral and Maxillofacial Surgery, The First People' s Hospital of Jining, Shandong (China); Department of Oral and Maxillofacial Surgery, Shandong Provincial Hospital, Affiliated to Shandong University, Jinan (China); Huang, S.Y. [Department of Oral and Maxillofacial Surgery, Shandong Provincial Hospital, Affiliated to Shandong University, Jinan (China); Zhang, D.S. [Department of Oral and Maxillofacial Surgery, School of Stomatology, Shandong University, Jinan (China); Department of Oral and Maxillofacial Surgery, Shandong Provincial Hospital, Affiliated to Shandong University, Jinan (China); Zhang, S.Z.; Li, W.G.; Chen, Z.W.; Wu, H.W. [Department of Oral and Maxillofacial Surgery, Shandong Provincial Hospital, Affiliated to Shandong University, Jinan (China)

    2014-12-12

    Reversion-inducing cysteine-rich protein with kazal motifs (RECK), a novel tumor suppressor gene that negatively regulates matrix metalloproteinases (MMPs), is expressed in various normal human tissues but downregulated in several types of human tumors. The molecular mechanism for this downregulation and its biological significance in salivary adenoid cystic carcinoma (SACC) are unclear. In the present study, we investigated the effects of a DNA methyltransferase (DNMT) inhibitor, 5-aza-2′deoxycytidine (5-aza-dC), on the methylation status of the RECK gene and tumor invasion in SACC cell lines. Methylation-specific PCR (MSP), Western blot analysis, and quantitative real-time PCR were used to investigate the methylation status of the RECK gene and expression of RECK mRNA and protein in SACC cell lines. The invasive ability of SACC cells was examined by the Transwell migration assay. Promoter methylation was only found in the ACC-M cell line. Treatment of ACC-M cells with 5-aza-dC partially reversed the hypermethylation status of the RECK gene and significantly enhanced the expression of mRNA and protein, and 5-aza-dC significantly suppressed ACC-M cell invasive ability. Our findings showed that 5-aza-dC inhibited cancer cell invasion through the reversal of RECK gene hypermethylation, which might be a promising chemotherapy approach in SACC treatment.

  9. Effects of 5-aza-2?deoxycytidine on RECK gene expression and tumor invasion in salivary adenoid cystic carcinoma

    X.Q., Zhou; S.Y., Huang; D.S., Zhang; S.Z., Zhang; W.G., Li; Z.W., Chen; H.W., Wu.

    Full Text Available Reversion-inducing cysteine-rich protein with kazal motifs (RECK), a novel tumor suppressor gene that negatively regulates matrix metalloproteinases (MMPs), is expressed in various normal human tissues but downregulated in several types of human tumors. The molecular mechanism for this downregulatio [...] n and its biological significance in salivary adenoid cystic carcinoma (SACC) are unclear. In the present study, we investigated the effects of a DNA methyltransferase (DNMT) inhibitor, 5-aza-2?deoxycytidine (5-aza-dC), on the methylation status of the RECK gene and tumor invasion in SACC cell lines. Methylation-specific PCR (MSP), Western blot analysis, and quantitative real-time PCR were used to investigate the methylation status of the RECK gene and expression of RECK mRNA and protein in SACC cell lines. The invasive ability of SACC cells was examined by the Transwell migration assay. Promoter methylation was only found in the ACC-M cell line. Treatment of ACC-M cells with 5-aza-dC partially reversed the hypermethylation status of the RECK gene and significantly enhanced the expression of mRNA and protein, and 5-aza-dC significantly suppressed ACC-M cell invasive ability. Our findings showed that 5-aza-dC inhibited cancer cell invasion through the reversal of RECK gene hypermethylation, which might be a promising chemotherapy approach in SACC treatment.

  10. {sup 125}I brachytherapy alone for recurrent or locally advanced adenoid cystic carcinoma of the oral and maxillofacial region

    Huang, M.W.; Zheng, L.; Liu, S.M.; Shi, Y.; Zhang, J.; Yu, G.Y.; Zhang, J.G. [Peking Univ. School and Hospital of Stomatology, Beijing (China). Dept. of Oral and Maxillofacial Surgery

    2013-06-15

    Background and purpose: This retrospective study was to evaluate the local control and survival of {sup 125}I brachytherapy for recurrent and/or locally advanced adenoid cystic carcinoma (ACC) of the oral and maxillofacial region. Patients and methods: A total of 38 patients with recurrent and/or locally advanced ACC of the oral and maxillofacial region received {sup 125}I brachytherapy alone from 2001-2010. Twenty-nine were recurrent cases following previous surgery and radiation therapy. The other 9 cases involved primary tumors. Overall, 12 tumors were located in the major salivary glands, 12 in the minor salivary glands, and 14 in the paranasal region, the nasal cavity or the skull base. The prescribed dose was 100-160 Gy. Results: Patients were followed for 12-122 months (median 51 months). The 2-, 5-, and 10-year local tumor control rates were 86.3, 59, and 31.5 %, respectively. The 2-, 5-, and 10-year overall survival rates were 92.1, 65 and 34.1 %, respectively. Tumors > 6 cm had significantly lower local control and survival rates. No severe complications were observed during follow-up. Conclusion: {sup 125}I brachytherapy is a feasible and effective modality for the treatment of locally advanced unresectable or recurrent ACC. (orig.)

  11. 125I brachytherapy alone for recurrent or locally advanced adenoid cystic carcinoma of the oral and maxillofacial region

    Background and purpose: This retrospective study was to evaluate the local control and survival of 125I brachytherapy for recurrent and/or locally advanced adenoid cystic carcinoma (ACC) of the oral and maxillofacial region. Patients and methods: A total of 38 patients with recurrent and/or locally advanced ACC of the oral and maxillofacial region received 125I brachytherapy alone from 2001-2010. Twenty-nine were recurrent cases following previous surgery and radiation therapy. The other 9 cases involved primary tumors. Overall, 12 tumors were located in the major salivary glands, 12 in the minor salivary glands, and 14 in the paranasal region, the nasal cavity or the skull base. The prescribed dose was 100-160 Gy. Results: Patients were followed for 12-122 months (median 51 months). The 2-, 5-, and 10-year local tumor control rates were 86.3, 59, and 31.5 %, respectively. The 2-, 5-, and 10-year overall survival rates were 92.1, 65 and 34.1 %, respectively. Tumors > 6 cm had significantly lower local control and survival rates. No severe complications were observed during follow-up. Conclusion: 125I brachytherapy is a feasible and effective modality for the treatment of locally advanced unresectable or recurrent ACC. (orig.)

  12. Increased numbers of P63-positive/CD117-positive cells in advanced adenoid cystic carcinoma give a poorer prognosis

    Zhou Quan

    2012-09-01

    Full Text Available Abstract Objectives This study consisted of two parts. One part was to analyze the survival rates of adenoid cystic carcinoma (ACC in Chinese and explain the difference between our data and the literature. The other was to analyze the relationship between the expression of CD117 and the histological grade and the prognosis. Methods A retrospective study of 80 ACC patients was performed. Clinical data were collected, and p63, CD117 were detected by immunohistochemical staining. Results Eighty patients received follow-ups 3 to 216 months after initial diagnosis. ACC occurred in the lacrimal gland (26.3%, n = 21, nasal cavity and parasinus (33.8%, n = 27 and other sites (40.0%, n = 33. The 5-year and 10-year survival rates were 66.41% and 10.16%, respectively. Over expression of CD117 was detected in p63-negative cells in 94.3% of cases and in p63-positive cells in 45.8%. The expression of CD117 in p63-positive cells was significantly associated with the histological grade (P Conclusions ACC had a good 5-year survival but poor 10-year survival in Chinese, which differed from the occidental data. More p63+/CD117+ cells were associated with a higher histological grade and poorer outcome. Virtual slides The virtual slide(s for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1701457278762097

  13. Effects of 5-aza-2?deoxycytidine on RECK gene expression and tumor invasion in salivary adenoid cystic carcinoma

    X.Q., Zhou; S.Y., Huang; D.S., Zhang; S.Z., Zhang; W.G., Li; Z.W., Chen; H.W., Wu.

    2015-03-01

    Full Text Available Reversion-inducing cysteine-rich protein with kazal motifs (RECK), a novel tumor suppressor gene that negatively regulates matrix metalloproteinases (MMPs), is expressed in various normal human tissues but downregulated in several types of human tumors. The molecular mechanism for this downregulatio [...] n and its biological significance in salivary adenoid cystic carcinoma (SACC) are unclear. In the present study, we investigated the effects of a DNA methyltransferase (DNMT) inhibitor, 5-aza-2?deoxycytidine (5-aza-dC), on the methylation status of the RECK gene and tumor invasion in SACC cell lines. Methylation-specific PCR (MSP), Western blot analysis, and quantitative real-time PCR were used to investigate the methylation status of the RECK gene and expression of RECK mRNA and protein in SACC cell lines. The invasive ability of SACC cells was examined by the Transwell migration assay. Promoter methylation was only found in the ACC-M cell line. Treatment of ACC-M cells with 5-aza-dC partially reversed the hypermethylation status of the RECK gene and significantly enhanced the expression of mRNA and protein, and 5-aza-dC significantly suppressed ACC-M cell invasive ability. Our findings showed that 5-aza-dC inhibited cancer cell invasion through the reversal of RECK gene hypermethylation, which might be a promising chemotherapy approach in SACC treatment.

  14. Effects of small interfering RNA targeting thymidylate synthase on survival of ACC3 cells from salivary adenoid cystic carcinoma

    Thymidylate synthase (TS) is an important target for chemotherapeutic treatment of cancer and high expression of TS has been associated with poor prognosis or refractory disease in several cancers including colorectal and head and neck cancer. Although TS is known to regulate cell cycles and transcription factors, its potency as a therapeutic target has not been fully explored in adenoid cystic carcinoma (ACC). An ACC cell line (ACC3) was transfected with siRNA targeting the TS gene and inhibition of cell growth and induction of apoptosis-associated molecules were evaluated in vitro. In addition, the in vivo effect of TS siRNA on tumor progression was assessed using a xenograft model. Our results demonstrated that ACC3 cells showed significantly higher TS expression than non-cancer cell lines and the induction of TS siRNA led to inhibition of cell proliferation. The effect was associated with an increase in p53, p21, and active caspase-3 and S-phase accumulation. We also found up-regulation of spermidine/spermine N1-acetyltransferase (SSAT), a polyamine metabolic enzyme. Furthermore, treatment with TS siRNA delivered by atelocollagen showed a significant cytostatic effect through the induction of apoptosis in a xenograft model. TS may be an important therapeutic target and siRNA targeting TS may be of potential therapeutic value in ACC

  15. Adenoid cystic carcinoma of head and neck: A single institutional analysis of 66 patients treated with multi-modality approach

    Ajeet Kumar Gandhi

    2015-01-01

    Full Text Available Background: Adenoid cystic carcinoma (ACC accounts for 1% of all head and neck (HN cancers. Materials and Methods: Demographic, clinical, treatment, and survival details of 66 patients were collected (1995-2011 and analyzed. Disease-free survival (DFS was estimated by Kaplan-Meier method. Results: Primary disease sites were sinonasal (n = 27, salivary gland (n = 30, and others (n = 9. Median follow-up was 23 months (range: 12-211 months. Estimated DFS at 2- and 5-year were 75% and 67.2%, respectively. On univariate analysis, intra-cranial extension (ICE (hazard ratio [HR]: 3.59, P = 0.0071, lymph node involvement (HR: 4.05, P = 0.0065, treatment modality (others vs. surgery plus adjuvant radiotherapy, HR: 2.39, P = 0.0286 and T stage (T3/4 vs. T1/2, HR: 3.27, P = 0.007 had significant impact on DFS. Lymph node involvement (P = 0.038 and ICE (P = 0.038 continued to have significant impact on DFS on multivariate analysis. Conclusion: Surgery followed by adjuvant radiotherapy remains the treatment of choice for HN ACC. Lymph node involvement and ICE confer poor prognosis.

  16. Effects of 5-aza-2′deoxycytidine on RECK gene expression and tumor invasion in salivary adenoid cystic carcinoma

    Reversion-inducing cysteine-rich protein with kazal motifs (RECK), a novel tumor suppressor gene that negatively regulates matrix metalloproteinases (MMPs), is expressed in various normal human tissues but downregulated in several types of human tumors. The molecular mechanism for this downregulation and its biological significance in salivary adenoid cystic carcinoma (SACC) are unclear. In the present study, we investigated the effects of a DNA methyltransferase (DNMT) inhibitor, 5-aza-2′deoxycytidine (5-aza-dC), on the methylation status of the RECK gene and tumor invasion in SACC cell lines. Methylation-specific PCR (MSP), Western blot analysis, and quantitative real-time PCR were used to investigate the methylation status of the RECK gene and expression of RECK mRNA and protein in SACC cell lines. The invasive ability of SACC cells was examined by the Transwell migration assay. Promoter methylation was only found in the ACC-M cell line. Treatment of ACC-M cells with 5-aza-dC partially reversed the hypermethylation status of the RECK gene and significantly enhanced the expression of mRNA and protein, and 5-aza-dC significantly suppressed ACC-M cell invasive ability. Our findings showed that 5-aza-dC inhibited cancer cell invasion through the reversal of RECK gene hypermethylation, which might be a promising chemotherapy approach in SACC treatment

  17. Multinucleated stromal giant cells in adenoid cystic carcinoma of the breast: A case report and literature review

    Jovičić-Milentijević Maja

    2011-01-01

    Full Text Available Background. We presented an unusual case of adenoid cystic carcinoma (ACC of the breast with multinucleated stromal giant cells (MSGCs. To the best of our knowledge, the occurrence of ACC with MSGCs has not been reported previously. MSGCs should be distinguished from other multinucleated giant cells in breast tumors. The histogenesis of MSGCs still remains obscure. In hope to elucidate the histogenesis of MSGCs, we used a broad range of antibodies. Case report. A 40-year-old woman presented with a palpable lump in the subareolar location of her right breast. Excision of the tumor was performed. At gross pathologic examination the tumor was 20 × 15 × 15 mm in size, redbrown and well circumscribed. The surgical margins were positive for carcinoma and skin-sparing mastectomy with axillary dissection was complited. Eighteen lymph nodes examined were uninvolved. Patohistological examination showed ACC with numerous MSGCs scattered within tumor stroma. Immunohistochemical studies indicated that MSGCs are probably derived from stromal fibroblasts. These cells showed strong reactivity only for vimentin. Staining for histiocytic marker (CD68, as well as for epithelial marker (cytokeratin, myoepithelial markers (S-100, α- smooth muscle actin, vascular marker (CD34, hormonal receptors (ER, PR and HER2 in MSGCs were negative. Conclusion. The presence of MSGCs should not alter the prognosis of an otherwise typical breast ACC.

  18. RadioImmunotherapy for adenoid cystic carcinoma: a single-institution series of combined treatment with cetuximab

    Weichert Wilko

    2010-11-01

    Full Text Available Abstract Background Local control in adjuvant/definitive RT of adenoid cystic carcinoma (ACC is largely dose-dependent. However, some clinical situations do not allow application of tumouricidal doses (i.e. re-irradiation hence radiation sensitization by exploitation of high endothelial growth factor receptor (EGFR-expression in ACC seems beneficial. This is a single-institution experience of combined radioimmunotherapy (RIT with the EGFR-inhibitor cetuximab. Methods Between 2006 and 2010, 9 pts received RIT for advanced/recurrent ACC, 5/9 pts as re-irradiation. Baseline characteristics as well as treatment parameters were retrieved to evaluate efficacy and toxicity of the combination regimen were evaluated. Control rates (local/distant and overall survival were calculated using Kaplan-Meier estimation. Results Median dose was 65 Gy, pts received a median of 6 cycles cetuximab. RIT was tolerated well with only one °III mucositis/dysphagia. Overall response/remission rates were high (77,8%; 2-year estimate of local control was 80% hence reaching local control levels comparable to high-dose RT. Progression-free survival (PFS at 2 years and median overall survival were only 62,5% and 22,2 mo respectively. Conclusion While local control and treatment response in RIT seems promising, PFS and overall survival are still hampered by distant failure. The potential benefit of RIT with cetuximab warrants exploration in a prospective controlled clinical trial.

  19. Thomsen-Friedenreich (T) antigen as marker of myoepithelial and basal cells in the parotid gland, pleomorphic adenomas and adenoid cystic carcinomas. An immunohistological comparison between T and sialosyl-T antigens, alpha-smooth muscle actin and cytokeratin 14

    Therkildsen, M H; Mandel, U; Christensen, M; Dabelsteen, Erik

    -known markers of normal MEC/basal cells (i.e. alpha-smooth muscle actin and cytokeratin 14) with T (Thomsen-Friedenreich) antigen and its sialylated derivative: sialosyl-T antigen,) in 17 normal parotid glands and in two tumour types with MEC participation (i.e pleomorphic adenomas (PA) and adenoid cystic...... the only marker of cells in solid undifferentiated areas of adenoid cystic carcinomas. Our study supports the view, that modified "myoepithelial" cells in the tumours consist of a mixture of basal cells and myoepithelial cells. None of the investigated structures was in itself an ideal marker in the...

  20. Efficacy of sorafenib, a multi-tyrosine kinase inhibitor, in an adenoid cystic carcinoma metastatic to the lung: case report and review of literature

    Santos Edgardo S

    2011-09-01

    Full Text Available Abstract Introduction Treatment for squamous cell carcinoma of the head and neck has significantly improved with the addition of cetuximab, a monoclonal antibody against the epidermal growth factor receptor, to conventional cytotoxic agents. The most significant aspect of this treatment approach is the proof that head and neck cancers are suitable for targeted therapies as has been shown in other malignancies. Unfortunately, there are other rare histologic types of head and neck cancer such as adenocarcinoma and adenoid cystic carcinoma. The latter has traditionally been considered to be chemotherapy resistant and surgical resection with or without adjuvant radiation therapy has been the rule as far as treatment is concerned. The course of adenoid cystic carcinoma ranges from indolent to aggressive; however, most patients succumb to the disease as a result of distant metastases. This clinical scenario poses a challenge to oncologists. Several conventional chemotherapy regimens and novel targeted agents have been tried in this rare histologic subtype without success. Case presentation In this case report, we present a 59-year-old Caucasian female with refractory adenoid cystic carcinoma of the maxilla metastatic to the lung that responded to sorafenib, a novel multi-tyrosine kinase inhibitor, which targets angiogenesis, Raf kinase pathway, platelet-derived growth factor Ret, and c-Kit. Conclusion This case illustrates the possibility that this chemoresistant tumor may need the inhibition or blocking of several oncogenic pathways. Certainly, it is imperative that more studies are done in this special population trying to identify tumorigenesis mechanisms that may be upregulated in this malignancy and could be potential targets for therapeutic development.

  1. Aggressive Adenoid Cystic Carcinoma With Asymptomatic Spinal Cord Compression Revealed By A “Curtain Sign”

    Martin Housset

    2008-08-01

    Full Text Available The author presents a case with an unusually aggressive evolution of an adenoid cystic carcinoma of the head and neck. The patient presented with sciatica one year after initial diagnosis. She was otherwise asymptomatic. Complete work-up for bone involvement, included bone scan and MRI. The patient had asymptomatic thoracic (T5 vertebral metastasis revealed by a typical curtain sign on MRI. She benefited from radiotherapy and did not develop respiratory distress, paraplegia or pain but died of other metastases.

  2. A 20-Year Retrospective Study of Salivary Gland Adenoid Cystic Carcinoma in a Sample of Iranian Patients

    M. Khalili

    2009-03-01

    Full Text Available Objective: The aim of the present study was to investigate the demographic and pathological aspects of adenoid cystic carcinomas (ACC in an Iranian sample based on a 20-year archive review.Materials and Methods: In this descriptive study, tumors of the head and neck registered between 1980 and 2000 were evaluated and cases of ACC were selected. Patients’ medical records and pathology reports were reviewed. Variables such as age, sex, duration of disease,symptoms, site of tumor involvement and tumor diameter as well as pathologic features were recorded. Analysis was performed using chi-square and t-tests; P<0.05 was considered as the level of significance.Results: ACC was the most common malignant tumor followed by mucoepidermoid carcinoma and adenocarcinoma NOS. A total of 120 ACCs were found, of which 50.8% occurred in females and 49.2% in males. Patients’ ages ranged from 5 to 90 with a mean of 49.2 (SD=15.9 years. In 60.9% of cases, minor salivary glands were involved and the palate was the most common site. The greatest tumor diameter was between 2-15cm with a mean of 4.6 cm (SD=2.9. The most prevalent histologic appearance was cribriform, followed by tubular pattern. No significant relation was observed between lymph node metastasisand patients’ age, sex, disease duration, greatest tumor diameter and site of involvement.Conclusion: Our findings were relatively similar to other reports from different parts of the world. Further analytic and case-control studies are recommended to gain a better understanding of different aspects of ACC.

  3. Immunohistochemical pattern of pleomorphic adenoma, polymorphous low grade adenocarcinoma and adenoid cystic carcinoma in minor salivary glands.

    Nadia Zaib

    2014-02-01

    Full Text Available To study the immunohistochemical pattern of CD 117, glial fibrillary acidic protein (GFAP, smooth muscle actin (SMA and CD 43 in pleomorphic adenoma (PA, adenoid cystic carcinoma (AdCC and polymorphous low grade adenocarcinoma (PLGA of minor salivary glands.Twenty cases of PA, 20 cases of AdCC and 10 cases of PLGA were retrieved from record files along with their paraffin blocks at Armed Forces Institute of Pathology, Pakistan. New histological diagnosis was made on freshly prepared H&E sections followed by application and analysis of immunostains.The mean age of the patients was 44 15 (mean SD (range; 17-86 years. There were 26 male and 24 female patients with a male to female ratio of 1.08:1. Fourteen cases of PA, 14 cases of AdCC and 6 cases of PLGA were positive for CD117. In case of GFAP, only 9 cases of AdCC and 3 cases of PLGA were positive; however, 16 cases of PA were also positive. Twelve cases of AdCC and 7 cases of PA were positive for SMA and half of the PLGA cases were also reactive. Nonetheless, the least expression was seen in case of CD 43, where only five cases of AdCC were positive. Six cases of PA and three cases of PLGA were also positive.Our results suggest that the use of GFAP, SMA, CD 117 and CD 43 as an adjunct to histological examination is not helpful in differentiating PA, AdCC and PLGA from one another.

  4. Bmi-1 expression predicts prognosis in salivary adenoid cystic carcinoma and correlates with epithelial-mesenchymal transition-related factors.

    Yi, Chun; Li, Bin-Bin; Zhou, Chuan-Xiang

    2016-06-01

    Salivary adenoid cystic carcinoma (AdCC) is known for its high propensity to invade and metastasize. Bmi-1 acts as an oncogene by controlling cell cycle and self-renewal of adult stem cells, and its overexpression correlates with metastasis and poor prognosis in several cancers. Epithelial-mesenchymal transition (EMT) plays a central role in cancer metastasis. A key step in EMT is the down-regulation of E-cadherin that can be repressed by the transcriptional factors, such as Snail and Slug. In the present study, we investigated Bmi-1, Snail, Slug, and E-cadherin expression by immunohistochemistry in 102 patients with AdCC and analyzed statistically whether their expression correlated with clinicopathologic factors and prognosis. Reverse transcription-polymerase chain reaction was also performed in 22 tumor tissues and the adjacent noncancerous tissues to confirm Bmi-1 status in AdCCs. Our data demonstrated significant associations between the tumor metastasis and the expression of Bmi-1, Snail, Slug, and E-cadherin. Furthermore, a high level of Bmi-1 was not only correlated with the overexpression of Snail and Slug but also indicated an unfavorable metastasis-free survival and served as a high-risk marker for AdCC. In addition, Bmi-1 messenger RNA level was found much higher in AdCC tissues than in the adjacent noncancerous salivary gland tissues. Our results suggest that Bmi-1 may play a crucial role in AdCC progression by interaction with EMT-related markers and predict poor survival. PMID:27180058

  5. Therapeutic strategies for adenoid cystic carcinoma of the nasal and paranasal sinus from the long-term treatment results

    This article presents long-term treatment results by analyzing 24 cases with adenoid cystic carcinoma (ACC) of the nasal and paranasal sinus treated from 1975 to 1995 at Akita University Hospital and Chiba University Hospital. The basic strategies for treatment for ACC of the nasal and paranasal sinuses are en bloc tumor resection, followed by primary reconstruction of the maxilla. Preoperative and postoperative radiation were combined. Cumulative 5-year and 10-year survival rates were 70.6% and 47.1% for maxillary sinus tumors, respectively. Cumulative 5-year and 10-year survival rates for nasal tumors were 100% and 75.0%, and those for sphenoid sinus tumors were 50.0% and 0%, respectively. The patient with ethomoid sinus who needed skull base surgery is alive at 8.1 years after therapy. Treatment results closely correlated with tumor extension. Cumulative 5-year survival rates for T2, T3 and, T4 patients with maxillary sinus tumors were 85.7%, 71.4%, and 33.3%, respectively. And cumulative 10-year survival rates for T2, T3, and T4 were 71.4%, 42.9%, and 0%, respectively. The histopathological effects of preoperative radiation were Shimosato II a in 6 out of 10 patients, II b in 2, and III in 2, respectively. Only fast neutron therapy reached Shimosato III. Two of the patients with Shimosato II a died of distant metastasis. The above data suggests that, although radiation therapy alone cannot cure tumors, preoperative full-dose radiation may prevent the development of distant metastasis if it can achieve histopathological effects of a higher classification than Shimosato II b. Because chemotherapy and radiation is not very effective on ACC, the role of skull base surgeries for nasal-paranasal sinus malignancies that invade the skull base is valuable, particularly in cases having a relatively small mass in the ethmoid sinus. (author)

  6. Primary adenoid cystic carcinoma of the tracheobronchial tree: A decade-long experience at a health centre in Mexico

    Arturo Cortés-Télles

    2012-01-01

    Full Text Available Background : Mexico′s National Institute of Respiratory Diseases (NIRD is a third-level national reference center. Primary adenoid cystic carcinoma (PACC is an uncommon neoplastic disorder; hence improvements in the description of this disease are needed. Materials and Methods: This is a retrospective clinical study based on all consecutive patients with pathological diagnoses of PACC seen at the NIRD between January 1, 2000 and December 31, 2009. Results: We identified 9 cases of PACC (67% female out of a total of 2,634 patients with lung cancer seen during the period analyzed. The mean age of those 9 patients was 41 years (IQR 36-57, and the frequency of PACC at our center was 0.3%. It is important to note that 67% of those patients had a history of smoking and that 6 of the 9 had the antecedent of previous exposure to biomass fuel smoke. Baseline arterial blood gas analyses revealed a median of 61 mmHg for pO 2 and 28.5 mmHg for pCO 2 . Median FVC was 78%, while FEV 1 was 77% with an FEV 1 /FVC ratio of 78. Death occurred in 56% of cases, and the median survival time was 17 months (IQR 6-26 after the initial diagnosis. Conclusions: The frequency of tracheobronchial PACC among patients with lung cancer was similar to that previously reported (0.3%. According to our results, lung function has no specific phenotype in this disease; however, some abnormalities could be related to potential risk factors such as tobacco use and exposure to biomass fuel smoke.

  7. Primary adenoid cystic carcinoma of the tracheobronchial tree: A decade-long experience at a health centre in Mexico

    Arturo Corts-Tlles

    2012-01-01

    Full Text Available Background : Mexico?s National Institute of Respiratory Diseases (NIRD is a third-level national reference center. Primary adenoid cystic carcinoma (PACC is an uncommon neoplastic disorder; hence improvements in the description of this disease are needed. Materials and Methods: This is a retrospective clinical study based on all consecutive patients with pathological diagnoses of PACC seen at the NIRD between January 1, 2000 and December 31, 2009. Results: We identified 9 cases of PACC (67% female out of a total of 2,634 patients with lung cancer seen during the period analyzed. The mean age of those 9 patients was 41 years (IQR 36-57, and the frequency of PACC at our center was 0.3%. It is important to note that 67% of those patients had a history of smoking and that 6 of the 9 had the antecedent of previous exposure to biomass fuel smoke. Baseline arterial blood gas analyses revealed a median of 61 mmHg for pO 2 and 28.5 mmHg for pCO 2 . Median FVC was 78%, while FEV 1 was 77% with an FEV 1 /FVC ratio of 78. Death occurred in 56% of cases, and the median survival time was 17 months (IQR 6-26 after the initial diagnosis. Conclusions: The frequency of tracheobronchial PACC among patients with lung cancer was similar to that previously reported (0.3%. According to our results, lung function has no specific phenotype in this disease; however, some abnormalities could be related to potential risk factors such as tobacco use and exposure to biomass fuel smoke.

  8. Combined treatment of adenoid cystic carcinoma with cetuximab and IMRT plus C12 heavy ion boost: ACCEPT [ACC, Erbitux® and particle therapy

    Local control in adjuvant/definitive RT of adenoid cystic carcinoma (ACC) is largely dose-dependent leading to the establishment of particle therapy in this indication. However, even modern techniques leave space for improvement of local control by intensification of local treatment. Radiation sensitization by exploitation of high EGFR-expression in ACC with the EGFR receptor antibody cetuximab seems promising. The ACCEPT trial is a prospective, mono-centric, phase I/II trial evaluating toxicity (primary endpoint: acute and late effects) and efficacy (secondary endpoint: local control, distant control, disease-free survival, overall survival) of the combined treatment with IMRT/carbon ion boost and weekly cetuximab in 49 patients with histologically proven (≥R1-resected, inoperable or Pn+) ACC. Patients receive 18 GyE carbon ions (6 fractions) and 54 Gy IMRT (2.0 Gy/fraction) in combination with weekly cetuximab throughout radiotherapy. The primary objective of ACCEPT is to evaluate toxicity and feasibility of cetuximab and particle therapy in adenoid cystic carcinoma. Clinical Trial Identifier: http://www.clinicaltrials.gov/ct2/show/NCT01192087 EudraCT number: 2010 - 022425 - 15

  9. Cervical adenoid basal carcinoma associated with invasive squamous cell carcinoma: A report of rare co-existence and review of literature

    Lee Chung Won

    2011-10-01

    Full Text Available Abstract Cervical adenoid basal carcinoma (ABC rarely can harbor associated malignancies like adenoid cystic carcinoma or squamous cell carcinoma (SCC, which express markedly different prognosis from a pure ABC, making an appropriate biopsy essential to provide a clear diagnosis and therapeutic plan. We report a 64-year-old asymptomatic lady with an abnormal cervical cytology, who underwent a conization to reveal an ABC with overlying microinvasive SCC. Doubtful resection margins led us to perform radical hysterectomy with lymph node dissection. Subsequent pathological examination showed a true invasive SCC co-existing with ABC, with invasion of the parametrium. Unlike the indolent course of many pure ABC patients, the prognosis of 11 previously reported co-existing invasive SCC with ABC patients appears to depend on the SCC component. Our case reiterates the importance of adequate biopsy with careful interpretation to cover the possibility of a co-existent malignancy. Besides, it presents an argument in favor of radical surgery for the primary treatment of suspicious associated malignancy, and supports adjuvant treatment according to the unfavorable extent of the co-existent invasive carcinoma.

  10. Interdisciplinary treatment of the patient with adenoid cystic carcinoma of the Bartholin’s gland resulting in 15 years’ survival: a case report and review of literature

    Marek Nowak

    2014-11-01

    Full Text Available Carcinoma of the Bartholin’s gland is very rare, comprises below 2% of Bartholin’s gland lesions and adenoid cystic carcinoma (ADC is one of the most uncommon variants and accounts for 10-15% of Bartholin’s gland malignancies. There is no consensus on treatment of ADC of the Bartholin’s gland: reported cases were treated with local excision or vulvectomy with or without lymphadenectomy followed or not by radiotherapy. The survival of patients varies significantly, so we present a case of interdisciplinary treatment of ADC resulting in 15 years’ survival. The patient was initially treated with local excision, but the margins were not clear. Then vulvectomy, inguinal lymphadenectomy and adjuvant brachytherapy were performed resulting in 7 years free of the disease. Relapses were excised by abdominoperineal amputation of the rectum and distal part of the vagina with sigmoideostomy, excisions of local recurrences in vagina and metastasectomy of isolated lung metastases. The patient died manifesting multiple lung metastases 15 years after the initial diagnosis. Based on our experience and world literature, in cases of adenoid cystic carcinoma of the Bartholin’s gland, vulvectomy with or without lymphadenectomy should be considered as a treatment of choice and in patients with positive margin, surgery should be extended by adjuvant radiotherapy.

  11. Combined treatment of adenoid cystic carcinoma with cetuximab and IMRT plus C12 heavy ion boost: ACCEPT [ACC, Erbitux® and particle therapy

    Hinke Axel

    2011-02-01

    Full Text Available Abstract Background Local control in adjuvant/definitive RT of adenoid cystic carcinoma (ACC is largely dose-dependent leading to the establishment of particle therapy in this indication. However, even modern techniques leave space for improvement of local control by intensification of local treatment. Radiation sensitization by exploitation of high EGFR-expression in ACC with the EGFR receptor antibody cetuximab seems promising. Methods/design The ACCEPT trial is a prospective, mono-centric, phase I/II trial evaluating toxicity (primary endpoint: acute and late effects and efficacy (secondary endpoint: local control, distant control, disease-free survival, overall survival of the combined treatment with IMRT/carbon ion boost and weekly cetuximab in 49 patients with histologically proven (≥R1-resected, inoperable or Pn+ ACC. Patients receive 18 GyE carbon ions (6 fractions and 54 Gy IMRT (2.0 Gy/fraction in combination with weekly cetuximab throughout radiotherapy. Discussion The primary objective of ACCEPT is to evaluate toxicity and feasibility of cetuximab and particle therapy in adenoid cystic carcinoma. Trial Registration Clinical Trial Identifier: NCT 01192087 EudraCT number: 2010 - 022425 - 15

  12. Growth of the nasopharynx and adenoidal development in Brazilian subjects Crescimento da nasofaringe e desenvolvimento da adenóide em brasileiros

    Beatriz de Souza Vilella

    2006-03-01

    Full Text Available The purpose of this research was to study the growth of the nasopharynx and adenoid development. Lateral cephalometric radiographs obtained from 320 white Brazilian subjects between 4 and 16 years of age were used. All the participants were nose breathers and none of them had previously undergone adenoidectomy. Tracings were made from the radiographs and cephalometric measurements were performed. The results showed that adenoid sagital thickness is larger in the age group 4 - 5 years and decreases progressively. There is a slight increase in the age group 10 - 11 years, but afterwards the decrease continues. However, the nasopharyngeal free airway space does not decrease in the age group 10 - 11 years, despite the increasing thickness of the adenoid. This is attributable to the downward displacement of the hard palate, resulting in an increase of the free airway space due to growth. Although the nasopharynx follows a growth pattern similar to that of the rest of the body, adenoid tissue does not. Adenoidal development seems to differ from that of other lymphatic tissues, showing a peculiar pattern that can be revealed when hypertrophy due to infections and allergies is eliminated.O objetivo da pesquisa foi estudar o crescimento da nasofaringe e o desenvolvimento da adenóide. Foram utilizadas as radiografias cefalométricas de perfil obtidas de 320 indivíduos brasileiros brancos, cujas idades variavam entre 4 e 16 anos. Todos os participantes apresentavam respiração predominantemente nasal e não haviam sido submetidos previamente à adenoidectomia. A partir das radiografias foram feitos traçados cefalométricos, sobre os quais foram realizadas medições. Os resultados revelaram que a espessura sagital da adenóide é maior na faixa etária de 4 a 5 anos, regredindo, então, progressivamente, até a faixa etária de 10 a 11 anos, quando ocorre um leve aumento, voltando a diminuir em seguida. O espaço aéreo livre nasofaríngeo, entretanto, não diminui na faixa etária de 10 a 11 anos, mesmo diante do aumento da espessura da adenóide. Esse fato se deve ao deslocamento do palato duro para baixo, o que determina a ampliação do espaço aéreo livre em razão do crescimento. Apesar de a nasofaringe seguir um padrão de crescimento similar ao do resto do corpo, a adenóide não o segue. O desenvolvimento da adenóide parece ser diferente do dos demais tecidos de origem linfóide, apresentando um padrão peculiar que pode ser percebido quando se elimina a hipertrofia causada por infecções e alergias.

  13. The effect of proteoglycans inhibited by RNA interference on metastatic characters of human salivary adenoid cystic carcinoma

    Salivary adenoid cystic carcinoma (SACC) is one of the most common malignancies of salivary gland. Recurrence or/and early metastasis is its biological properties. In SACC, neoplastic myoepithelial cells secrete proteoglycans unconventionally full of the cribriform or tubular and glandular structures of SACC. Literatures have demonstrated that extracellular matrix provided an essential microenvironment for the biological behavior of SACC. However, there is rare study of the effect of proteoglycans on the potential metastasis of SACC. In this study, human xylosyltransferase-I (XTLY-I) gene, which catalyzes the rate-limited step of proteoglycans biosynthesis, was knocked down by RNA interference (RNAi) to inhibit the proteoglycans biosynthesis in SACC cell line with high tendency of lung metastasis (SACC-M). The impact of down-regulated proteoglycans on the metastasis characters of SACC-M cells was analyzed and discussed. This research could provide a new idea for the clinical treatment of SACC. The eukaryotic expression vector of short hairpin RNA (shRNA) targeting XTLY-I gene was constructed and transfected into SACC-M cells. A stably transfectant cell line named SACC-M-WJ4 was isolated. The XTLY-I expression was measured by real-time PCR and Western blot; the reduction of proteoglycans was measured. The invasion and metastasis of SACC-M-WJ4 cells were detected; the effect of down-regulated proteoglycans on the potential lung metastasis of nude mice was observed, respectively. The shRNA plasmid targeting XTLY-I gene showed powerful efficiency of RNAi. The mRNA level of target gene decreased by 86.81%, the protein level was decreased by 80.10%, respectively. The silence of XTLY-I gene resulted in the reduction of proteoglycans significantly in SACC-M-WJ4 cells. The inhibitory rate of proteoglycans was 58.17% (24 h), 66.06% (48 h), 57.91% (72 h), 59.36% (96 h), and 55.65% (120 h), respectively. The reduction of proteoglycans suppressed the adhesion, invasion and metastasis properties of SACC-M cells, and decreased the lung metastasis of SACC-M cells markedly either. The data suggested that the silence of XTLY-I gene in SACC-M cells could suppress proteoglycans biosynthesis and secretion significantly. The reduction of proteoglycans inhibited cell adhesion, invasion and metastasis of SACC-M cells. There is a close relationship between proteoglycans and the biological behavior of SACC

  14. Adenoid cystic carcinoma of the lower trachea treated by resection of 11 of 18 rings of the total length: report of a case.

    Nomori, Hiroaki; Abe, Masaru; Sugimura, Hiroshi; Takeshi, Akihiko

    2016-04-01

    We report the case of a 63-year-old woman with adenoid cystic carcinoma of the lower trachea treated by resection of 11 of the 18 cartilaginous rings (61 %) of the total length. The little remaining membranous portion of the carina was sewn up to create a margin for anastomosis. The anastomotic sites could be approximated by the mobilization of the cervical trachea and the left main bronchus, pulling across the traction sutures, and anteflexion of the neck. The patient's postoperative course was uneventful without any complications associated with anastomosis. Because both the proximal and distal margins showed microscopic tumors, radiation therapy was performed with 50 Gy 2 months after surgery. The patient has a good social life without recurrence 20 months after surgery. PMID:25261213

  15. In vitro angiogenesis and expression of nuclear factor κB and VEGF in high and low metastasis cell lines of salivary gland Adenoid Cystic Carcinoma

    Adenoid cystic carcinoma is a high malignant carcinoma characterized by intensive local invasion and high incidence of distant metastasis. Although many reports have demonstrated that angiogenesis has played an important role in tumor metastasis, the relationship between metastasis characters and angiogenesis ability in high and low metastasis cell lines of Adenoid cystic carcinoma has rarely been reported. The present study aimed to compare the angiogenesis ability of ACC-M (high metastasis) and ACC-2 (low metastasis) cell lines in vitro. Furthermore, the activity of nuclear factor κappa B and the expression of vascular endothelial growth factor (VEGF) in ACC-2 and ACC-M were also detected. Electrophoretic mobility shift assay was used to detect nuclear factor κappa B activity. Semi-quantitative RT-PCR was used to quantify the mRNA level of VEGF. Immuofluorescence double staining and semi-quantitative confocal laser scanning analysis was carried out to detect nuclear factor κappa B nuclear localization and staining intensity of VEGF. The angiogenesis ability of ACC-M and ACC-2 was compared by an in vitro three-dimensional angiogenic model assay. The vector transfection assay was performed to transfect the PCMV-IκBαM vector into ACCs cell lines expressing the phosphorylation defective IκBαM. Nuclear factor κappa B activity and the rate of nuclear factor κappa B nuclear localization in ACC-M was significantly higher than that in ACC-2. Moreover, ACC-M exhibited higher mRNA and protein levels of vascular endothelial growth factor than ACC-2. VEGF mRNA expression was effectively decreased by inhibition of nuclear factor κappa B activity. Furthermore, ACC-M could remarkably stimulate the migration and tube formation of endothelial cells and induce The umbilical vein endothelial cells sprouting into the gel matrix. These results implicated that ACCs cells with higher metastasis feature might present greater angiogenesis ability

  16. Adenoid removal - series (image)

    ... child has chronic ear infections that: interfere with child's education persist despite antibiotic treatment recur 5 or more times in a year recur 3 or more times a year during a 2-year ... if the child has chronic or repeated bouts of tonsillitis. The ...

  17. Adenoid Cystic Carcinoma

    Jump to navigation ASCO Conquer Cancer Foundation Journal of Clinical Oncology Journal of Oncology Practice ASCO University Donate eNEWS SIGNUP f t y g m Menu H Types of Cancer Navigating Cancer Care Coping ...

  18. Comparação entre a radiografia de cavum e a cefalométrica de perfil na avaliação da nasofaringe e das adenoides por otorrinolaringologistas Comparison between cavum and lateral cephalometric radiographs for the evaluation of the nasopharynx and adenoids by otorhinolaryngologists

    Rhita Cristina Cunha Almeida

    2011-02-01

    Full Text Available INTRODUÇÃO: tanto a radiografia cefalométrica de perfil quanto a de cavum permitem a avaliação do espaço aéreo nasofaríngeo (EAN. Não é rara a solicitação dos otorrinolaringologistas de radiografia de cavum, mesmo o paciente possuindo uma cefalométrica. OBJETIVOS: objetivou-se (a conhecer quais exames os otorrinolaringologistas solicitam para avaliar o EAN; (b verificar o conhecimento da cefalométrica por otorrinolaringologistas; (c comparar a avaliação de otorrinolaringologistas nas duas técnicas radiográficas para a medição e a visualização do EAN e da adenoide; (d correlacionar os resultados do método de inspeção visual com os da medição de Schulhof. MÉTODOS: foram obtidas, no mesmo dia, radiografias cefalométricas e de cavum de 15 pacientes respiradores bucais. Essas foram cobertas com papel cartão, deixando visível apenas o EAN e adenoides e foram avaliadas por 12 otorrinolaringologistas. Estes respondiam sobre sua familiaridade com a cefalométrica, quais exames solicitam para visualizar EAN e adenoides e se utilizam algum método de medição do grau de obstrução. Avaliavam qual das radiografias apresentava a melhor visualização da adenoide e do EAN, e classificavam o tamanho dos mesmos em pequeno, médio ou grande, através de método visual. RESULTADOS: os resultados demonstraram que todos os otorrinolaringologistas costumam solicitar a radiografia de cavum. Apenas um solicita a cefalométrica, dois estão familiarizados com essa técnica e um utiliza algum método de medição do EAN. A cefalométrica foi preferida por 49,4% dos otorrinolaringologistas, a de cavum por 22,8%, enquanto 27,8% não observaram diferença entre ambas. Foi encontrada baixa correlação entre o método de medição visual e o de Schulhof.INTRODUCTION: The lateral cephalometric as well as the cavum radiograph allow the evaluation of the nasopharyngeal airway (NAW. Otorhinolaryngologists routinely use the cavum radiograph, even when the patient already has a lateral cephalometric headfilm. OBJECTIVES: The aim of this study was to (a acknowledge which exams otorhinolaryngologists use for the evaluation and measurement of the NAW; (b evaluate if the otorhinolaryngologists are acquainted to the cephalometric; (c compare both radiographs to see which one is preferred to visualize the NAW and adenoids and (d correlate the visual analysis to the measuring method of Schulhof. METHODS: For this purpose, the cephalometric and the cavum radiographs of 15 mouth-breathing children were taken on the same day. These radiographs were masked leaving only the NAW and the adenoids visible, and were blindly presented to 12 otorhinolaryngologists. They received the radiographs together with a questionnaire asking on their familiarity with the lateral cephalometric, which exams are used for NAW and adenoid evaluation and if they use any method for measuring the NAW obstruction level. They were also asked to visually classify the NAW and the adenoids according to their sizes into small, medium and large. RESULTS: The results demonstrated that all otorhinolaryngologists in the sample use the cavum radiograph. Only one uses the cephalometric radiograph and two are familiar to this technique. The cephalometric was preferred by 49.4% of the otorhinolaryngologists, the cavum by 22.8% and 27.8% did not see any difference between both methods. There was low correlation between the visual method and the Schulhof measuring method.

  19. The influence of positive margins and nerve invasion in adenoid cystic carcinoma of the head and neck treated with surgery and radiation

    Purpose: Surgery is the primary treatment for adenoid cystic carcinomas arising from major and minor salivary glands of the head and neck. However, local recurrence is frequent because of the infiltrative growth pattern and perineural spread associated with these tumors. At UTMDACC, we have had a long-standing policy of using postoperative radiotherapy to reduce the risk of local recurrence and to avoid the need for radical surgery; this 30-year retrospective study analyzes the results of this combined modality approach. Methods and Materials: Between 1962 and 1991, 198 patients ages 13-82 years, with adenoid cystic carcinomas of the head and neck, received postoperative radiotherapy for known or suspected microscopic residual disease following surgery. Distribution of primary sites was: parotid: 30 patients; submandibular/sublingual: 41 patients; lacrimal: 5 patients; and minor salivary glands: 122 patients. Eighty-three patients (42%) had microscopic positive margins and an additional 55 (28%) had close (≤5 mm) or uncertain margins. One hundred thirty-six patients (69%) had perineural spread with invasion of a major (named) nerve in 55 patients (28%). Using radiation techniques appropriate to the primary site, a median dose of 60 Gy (range 50-69 Gy) was delivered to the tumor bed. Follow-up ranged from 5-341 months (median, 93 months). All surviving patients had a minimum of 2 years follow-up. Results: Twenty-three patients (12%) had local recurrences with 5-, 10-, and 15-year actuarial local control rates of 95%, 86%, and 79%, respectively. Fifteen of the 83 patients (18%) with positive margins developed local recurrences, compared to 5 of 55 patients (9%) with close or uncertain margins, and 3 of 60 patients (5%) with negative margins (p 0.02). Patients with and without a major (named) nerve involved had crude failure rates of 18% (10 out of 55) and 9% (13 out of 143), respectively (p 0.02). There was a trend toward better local control with increasing dose. This was significant in patients with positive margins, in whom crude control rates were 40 and 88% for doses of <56 Gy and ≥56 Gy, respectively (p 0.006). Actuarial 5-, 10-, and 15-year freedom from relapse rates were 68%, 52%, and 45%, respectively. Base of skull and neck failures were uncommon with or without elective treatment, developing in 2 and 3% of patients, respectively. Distant metastases were the most common type of disease recurrence, developing in 74 patients (37%) of whom 62 (31%) were disease-free at the primary site. Conclusions: Excellent local control rates were obtained in this population using surgery and postoperative radiotherapy and we recommend this combined approach for most patients with adenoid cystic carcinomas of the head and neck. Perineural invasion was an adverse prognostic factor only when a major (named) nerve was involved. Microscopic positive margins was also an adverse prognostic factor, but even when present, local control was achieved in over 80% of our patients. We recommend a dose of 60 Gy to the tumor bed, supplemented to 66 Gy for patients with positive margins. Despite effective local therapy, one-third of patients fail systemically, and good treatment to address this problem is lacking

  20. Accuracy of methionine-PET in predicting the efficacy of heavy-particle therapy on primary adenoid cystic carcinomas of the head and neck

    We evaluated whether or not PET or PET/CT using L-methyl-[11C]-methionine (MET) can allow for the early prediction of local recurrence and metastasis, as well as the prognosis (disease-specific survival), in patients with adenoid cystic carcinoma of the head and neck treated by carbon ion beam radiotherapy. This was a retrospective cohort study of sixty-seven patients who underwent a MET-PET or PET/CT study prior to and one month after the completion of carbon ion radiotherapy (CIRT). The minimum follow-up period for survivors was 12 months. The MET accumulation of the tumor was evaluated using the semiquantitative tumor to normal tissue ratio (TNR). A univariate analysis was conducted using the log-rank method, and the Cox model was used in a multivariate survival regression analysis. The average TNR prior to and following treatment was 4.8 (±1.5) and 3.0 (±1.3), respectively, showing a significant decrease following treatment. In the univariate analysis, a high TNR prior to treatment (TNRpre) was a significant factor for predicting the occurrence of metastasis and the disease-specific survival. A high TNR following treatment (TNRpost) was a significant factor for predicting the development of local recurrence. The residual ratio of TNR changes (TNRratio) seemed to be less useful than the TNRpre. In the multivariate analysis, the TNRpost and tumor size were the factors found to significantly influence the risk of local recurrence. The TNRpre, TNRratio and tumor size were all significant factors influencing the occurrence of metastasis. Regarding the disease-specific survival, the TNRpre and age were the only factors with a significant influence on the outcome. The TNRpre was a factor that was significantly related to the occurrence of metastasis and the disease-specific survival after CIRT for adenoid cystic carcinoma of the head and neck. The TNRpost was a factor that was significantly related to the development of local recurrence. Thus, MET-PET or PET/CT can be useful for predicting or determining the therapeutic efficacy of CIRT

  1. Expression of beclin 1 in primary salivary adenoid cystic carcinoma and its relation to Bcl-2 and p53 and prognosis

    Beclin 1 plays a critical role in autophagy and functions as a haploinsufficient tumor suppressor. The expression and prognostic significance of beclin 1 in head and neck adenoid cystic carcinoma (ACC) are largely unexplored. Therefore, we investigated the expression of beclin 1, Bcl-2, and p53 in head and neck ACC tissue. Tissue samples from 35 cases (15 females, 20 males) of head and neck ACC were utilized for immunohistochemistry. Beclin 1 expression was observed in 32 cases (91.4%) and considered to be high in 15 cases (42.9%) and low in 20 cases (57.1%). Beclin 1 expression was significantly correlated with a histological growth pattern (P=0.046) and histological grade (P=0.037). Beclin 1 expression was inversely correlated with Bcl-2 expression (P=0.013) and significantly associated with overall survival (P=0.006). Bcl-2 and p53 expression were observed in 21 cases (60.0%) and 16 cases (45.7%). Bcl-2 expression was significantly correlated with perineural invasion (P=0.041) and not associated with overall survival (P=0.053). p53 expression was directly correlated with beclin 1 expression (P=0.044). Our results indicated that beclin 1 may be a novel, promising prognostic factor for clinical outcome in head and neck ACC patients and may play a part in the development of head and neck ACC by interacting with Bcl-2 and p53

  2. Type III TGF-? receptor inhibits cell proliferation and migration in salivary glands adenoid cystic carcinoma by suppressing NF-?B signaling.

    Xu, Dongyang; Li, Duo; Lu, Zhiyong; Dong, Xingli; Wang, Xiaofeng

    2016-01-01

    It is known that the TGF-? superfamily receptors act as master regulators of cancer progression. However, alteration and role of typeIII TGF-? receptor (T?RIII, or betaglycan) as the most abundant of the TGF-? receptor has not been explored in salivary gland adenoid cystic carcinoma (ACC). Here, we reported that tumor biopsies and matched normal human salivary glands from patients with ACC were examined for the expression of T?RIII. The expression of T?RIII protein is significantly decreased in ACC patients based on immunohistochemistry and western blot analysis. Invitro, a transient overexpression of T?RIII markedly induced apoptosis and cell cycle arrest in the G2/Mphase, thereby inhibited cell viability and migration of ACC-M cells. Co-immunoprecipitation revealed that T?RIII, scaffolding protein-arrestin2 (?-arrestin2) and I?B? formed a complex. Transient overexpression of T?RIII decreased p-p65 expression and increased I?B? expression, which was abolished by knockdown of ?-arrestin2. The present study defines T?RIII as a biomarker exerting antitumor action on ACC progression.Gene therapy of T?RIII may be a powerful new approach for ACC disease. PMID:26531330

  3. Expression of beclin 1 in primary salivary adenoid cystic carcinoma and its relation to Bcl-2 and p53 and prognosis

    Jiang, L.C.; Huang, S.Y.; Zhang, D.S.; Zhang, S.H.; Li, W.G.; Zheng, P.H.; Chen, Z.W. [Shandong Provincial Hospital Affiliated to Shandong University, Department of Oral and Maxillofacial Surgery, Jinan, China, Department of Oral and Maxillofacial Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan (China)

    2014-03-03

    Beclin 1 plays a critical role in autophagy and functions as a haploinsufficient tumor suppressor. The expression and prognostic significance of beclin 1 in head and neck adenoid cystic carcinoma (ACC) are largely unexplored. Therefore, we investigated the expression of beclin 1, Bcl-2, and p53 in head and neck ACC tissue. Tissue samples from 35 cases (15 females, 20 males) of head and neck ACC were utilized for immunohistochemistry. Beclin 1 expression was observed in 32 cases (91.4%) and considered to be high in 15 cases (42.9%) and low in 20 cases (57.1%). Beclin 1 expression was significantly correlated with a histological growth pattern (P=0.046) and histological grade (P=0.037). Beclin 1 expression was inversely correlated with Bcl-2 expression (P=0.013) and significantly associated with overall survival (P=0.006). Bcl-2 and p53 expression were observed in 21 cases (60.0%) and 16 cases (45.7%). Bcl-2 expression was significantly correlated with perineural invasion (P=0.041) and not associated with overall survival (P=0.053). p53 expression was directly correlated with beclin 1 expression (P=0.044). Our results indicated that beclin 1 may be a novel, promising prognostic factor for clinical outcome in head and neck ACC patients and may play a part in the development of head and neck ACC by interacting with Bcl-2 and p53.

  4. Treatment outcomes of particle radiotherapy using protons or carbon ions as a single-modality therapy for adenoid cystic carcinoma of the head and neck

    Background and purpose: The aim of this study was to retrospectively analyse the outcomes of cases of adenoid cystic carcinomas (ACCs) of the head and neck that were treated at a single institution with particle therapy consisting of either protons or carbon ions. Methods and materials: Between February 2002 and March 2012, 80 patients were treated with proton therapy (PT) or carbon ion therapy (CIT) alone. PT and CIT were employed in 40 (50%) patients each, and more than half of the patients received 65.0 GyE in 26 fractions (n = 47, 59%). Results: The median duration of follow-up was 38 months (range, 6–115 months). For all patients, the 5-year for overall survival (OS) rate, progression-free survival (PFS) rate, and local control (LC) rate were 63%, 39%, and 75%, respectively. No significant differences between PT and CIT were observed. The 5-year LC rates for T4 and inoperable cases were 66% and 68%, respectively. Twenty-one patients (26%) experienced grade 3 or greater late toxicities, including three patients who developed grade 5 bleeding from nasopharyngeal ulcers. Conclusions: Particle radiotherapy for ACC achieves favourable LC, and its efficacy in inoperable or T4 cases is promising. There were no significant differences between PT and CIT in terms of OS, PFS and LC

  5. c-Kit Expression is Rate-Limiting for Stem Cell Factor-Mediated Disease Progression in Adenoid Cystic Carcinoma of the Salivary Glands

    Janyaporn Phuchareon

    2014-10-01

    Full Text Available Adenoid cystic carcinoma (ACC is an aggressive malignant neoplasm of the salivary glands in which c-Kit is overexpressed and activated, although the mechanism for this is as yet unclear. We analyzed 27 sporadic ACC tumor specimens to examine the biologic and clinical significance of c-Kit activation. Mutational analysis revealed expression of wild-type c-Kit in all, eliminating gene mutation as a cause of activation. Because stem cell factor (SCF is c-Kit's sole ligand, we analyzed its expression in the tumor cells and their environment. Immunohistochemistry revealed its presence in c-Kitpositive tumor cells, suggesting an activation of autocrine signaling. We observed a significant induction of ERK1/2 in the cells. SCF staining was also found in other types of non-cancerous cells adjacent to tumors within salivary glands, including stromal fibroblasts, neutrophils, peripheral nerve, skeletal muscle, vascular endothelial cells, mucous acinar cells, and intercalated ducts. Quantitative PCR showed that the top quartile of c-Kit mRNA expression distinguished ACCs from normal salivary tissues and was cross-correlated with short-term poor prognosis. Expression levels of SCF and c-Kit were highly correlated in the cases with perineural invasion. These observations suggest that c-Kit is potentially activated by receptor dimerization upon stimulation by SCF in ACC, and that the highest quartile of c-Kit mRNA expression could be a predictor of poor prognosis. Our findings may support an avenue for c-Kit-targeted therapy to improve disease control in ACC patients harboring the top quartile of c-Kit mRNA expression.

  6. Mutations in the c-Kit Gene Disrupt Mitogen-Activated Protein Kinase Signaling during Tumor Development in Adenoid Cystic Carcinoma of the Salivary Glands

    Osamu Tetsu

    2010-09-01

    Full Text Available The Ras/mitogen-activated protein kinase (MAPK pathway is considered to be a positive regulator of tumor initiation, progression, and maintenance. This study reports an opposite finding: we have found strong evidence that the MAPK pathway is inhibited in a subset of adenoid cystic carcinomas (ACCs of the salivary glands. ACC tumors consistently overexpress the receptor tyrosine kinase (RTK c-Kit, which has been considered a therapeutic target. We performed mutational analysis of the c-Kit gene (KIT in 17 cases of ACC and found that 2 cases of ACC had distinct missense mutations in KIT at both the genomic DNA and messenger RNA levels. These mutations caused G664R and R796G amino acid substitutions in the kinase domains. Surprisingly, the mutations were functionally inactive in cultured cells. We observed a significant reduction of MAPK (ERK1/2 activity in tumor cells, as assessed by immunohistochemistry. We performed further mutational analysis of the downstream effectors in the c-Kit pathway in the genes HRAS, KRAS, NRAS, BRAF, PIK3CA, and PTEN. This analysis revealed that two ACC tumors without KIT mutations had missense mutations in either KRAS or BRAF, causing S17N K-Ras and V590I B-Raf mutants, respectively. Our functional analysis showed that proteins with these mutations were also inactive in cultured cells. This is the first time that MAPK activity from the RTK signaling has been shown to be inhibited by gene mutations during tumor development. Because ACC seems to proliferate despite inactivation of the c-Kit signaling pathway, we suggest that selective inhibition of c-Kit is probably not a suitable treatment strategy for ACC.

  7. MYB-NFIB gene fusion in adenoid cystic carcinoma of the breast with special focus paid to the solid variant with basaloid features.

    D'Alfonso, Timothy M; Mosquera, Juan Miguel; MacDonald, Theresa Y; Padilla, Jessica; Liu, Yi-Fang; Rubin, Mark A; Shin, Sandra J

    2014-11-01

    Adenoid cystic carcinomas (ACCs) from various anatomical sites harbor a translocation t(6;9)(q22-23;p23-24), resulting in MYB-NFIB gene fusion. This gene fusion is not well studied in mammary ACCs, and there are no studies examining this abnormality in solid variant of ACC with basaloid features (SBACC), a high-grade variant thought to behave more aggressively than ACCs with conventional histologic growth. Our aim was to investigate the frequency of MYB-NFIB gene fusion in mammary ACCs with a focus paid to SBACC. MYB rearrangement and MYB-NFIB fusion were assessed by fluorescence in situ hybridization and reverse-transcription polymerase chain reaction, respectively. Histologic features and the presence of MYB rearrangement were correlated with clinical outcome. MYB rearrangement was present in 7 (22.6%) of 31 mammary ACCs (5/15 [33.3%] ACCs with conventional growth; 2/16 [12.5%] SBACCs). One patient with conventional ACC developed distant metastasis, and no patients had axillary lymph node involvement by ACC (mean follow-up, 34 months; range, 12-84 months). Two patients with SBACC had axillary lymph node involvement at initial surgery, and 2 additional patients experienced disease recurrence (1 local, 1 distant; mean follow-up, 50 months; range, 9-192 months). MYB-NFIB fusion status did not correlate with clinical outcome in studied patients. We confirm that MYB-NFIB gene fusion is observed in mammary ACCs and that a subset lacks this abnormality. This study is the first to confirm the presence of MYB rearrangement in SBACC. Additional validation with long-term follow-up is needed to determine the relationship, if any, between MYB-NFIB gene fusion and clinical outcome. PMID:25217885

  8. 18F-FDG PET/CT in Patients with Initially Diagnosed Adenoid Cystic Carcinoma of the Head and Neck: Clinicoplathologic Correlation

    We evaluated 18F-FDG PET/CT findings in initially diagnosed adenoid cystic carcinoma (ACC) of the head and neck in association with pathological subtype, staging, uptake comparison with squamous cell carcinoma (SqCC) and prognosis. The subjects were 16 patients with initially diagnosed ACC of head and neck who underwent pretreatment 18F-FDG PET/CT. Histological subtype (solid pattern vs. tubular/cribriform pattern), SUVmax of size-matched SqCC of the head and neck as control group, disease-free survival (DFS) were compared with the SUVmax of ACC of the head and neck. Of total 16 patients, 6 had solid pattern and the remaining 10 had tubular/cribriform pattern. The SUVmax were significantly higher in solid pattern group than in tubular/cribriform pattern group (6.73.2 vs. 4.20.9, p=0.03). PET/CT found unexpected distant metastasis in 18.7% of patients (3/16) and changed the therapeutic plan in those patients. The SUVmax of ACC was significantly lower than that of size-matched SqCC (5.12.4 vs. 13.66.0, p18F-FDG uptake (SUVmax ?6.0) had significantly shorter DFS than those with low 18F-FDG uptake (SUVmax 18F-FDG uptake of ACC of the head and neck is significantly associated with histological subtype and DFS. 18F-FDG PET/CT may be useful for detecting unexpected metastasis. Since 18F-FDG uptake of tubular/cribriform ACC compared with SqCC is relatively low, it is necessary to interpret PET images carefully in patients without alleged ACC

  9. The T-box transcription factor Brachyury regulates epithelial–mesenchymal transition in association with cancer stem-like cells in adenoid cystic carcinoma cells

    The high frequencies of recurrence and distant metastasis of adenoid cystic carcinoma (AdCC) emphasize the need to better understand the biological factors associated with these outcomes. To analyze the mechanisms of AdCC metastasis, we established the green fluorescence protein (GFP)-transfected subline ACCS-GFP from the AdCC parental cell line and the metastatic ACCS-M GFP line from an in vivo metastasis model. Using these cell lines, we investigated the involvement of the epithelial–mesenchymal transition (EMT) and cancer stem cell (CSCs) in AdCC metastasis by real-time RT-PCR for EMT related genes and stem cell markers. Characteristics of CSCs were also analyzed by sphere-forming ability and tumorigenicity. Short hairpin RNA (shRNA) silencing of target gene was also performed. ACCS-M GFP demonstrated characteristics of EMT and additionally displayed sphere-forming ability and high expression of EMT-related genes (Snail, Twist1, Twist2, Slug, zinc finger E-box binding homeobox 1 and 2 [Zeb1 and Zeb2], glycogen synthase kinase 3 beta [Gsk3β and transforming growth factor beta 2 [Tgf-β2]), stem cell markers (Nodal, Lefty, Oct-4, Pax6, Rex1, and Nanog), and differentiation markers (sex determining region Y [Sox2], Brachyury, and alpha fetoprotein [Afp]). These observations suggest that ACCS-M GFP shows the characteristics of CSCs and CSCs may be involved in the EMT of AdCC. Surprisingly, shRNA silencing of the T-box transcription factor Brachyury (also a differentiation marker) resulted in downregulation of the EMT and stem cell markers. In addition, sphere-forming ability, EMT characteristics, and tumorigenicity were simultaneously lost. Brachyury expression in clinical samples of AdCC was extremely high and closely related to EMT. This finding suggests that regulation of EMT by Brachyury in clinical AdCC may parallel that observed in vitro in this study. The use of a single cell line is a limitation of this study. However, parallel data from in vitro and clinical samples suggest the possibility that EMT is directly linked to CSCs and that Brachyury is a regulator of EMT and CSCs

  10. The T-box transcription factor Brachyury regulates epithelial–mesenchymal transition in association with cancer stem-like cells in adenoid cystic carcinoma cells

    Shimoda Miyuki

    2012-08-01

    Full Text Available Abstract Background The high frequencies of recurrence and distant metastasis of adenoid cystic carcinoma (AdCC emphasize the need to better understand the biological factors associated with these outcomes. To analyze the mechanisms of AdCC metastasis, we established the green fluorescence protein (GFP-transfected subline ACCS-GFP from the AdCC parental cell line and the metastatic ACCS-M GFP line from an in vivo metastasis model. Methods Using these cell lines, we investigated the involvement of the epithelial–mesenchymal transition (EMT and cancer stem cell (CSCs in AdCC metastasis by real-time RT-PCR for EMT related genes and stem cell markers. Characteristics of CSCs were also analyzed by sphere-forming ability and tumorigenicity. Short hairpin RNA (shRNA silencing of target gene was also performed. Results ACCS-M GFP demonstrated characteristics of EMT and additionally displayed sphere-forming ability and high expression of EMT-related genes (Snail, Twist1, Twist2, Slug, zinc finger E-box binding homeobox 1 and 2 [Zeb1 and Zeb2], glycogen synthase kinase 3 beta [Gsk3β and transforming growth factor beta 2 [Tgf-β2], stem cell markers (Nodal, Lefty, Oct-4, Pax6, Rex1, and Nanog, and differentiation markers (sex determining region Y [Sox2], Brachyury, and alpha fetoprotein [Afp]. These observations suggest that ACCS-M GFP shows the characteristics of CSCs and CSCs may be involved in the EMT of AdCC. Surprisingly, shRNA silencing of the T-box transcription factor Brachyury (also a differentiation marker resulted in downregulation of the EMT and stem cell markers. In addition, sphere-forming ability, EMT characteristics, and tumorigenicity were simultaneously lost. Brachyury expression in clinical samples of AdCC was extremely high and closely related to EMT. This finding suggests that regulation of EMT by Brachyury in clinical AdCC may parallel that observed in vitro in this study. Conclusions The use of a single cell line is a limitation of this study. However, parallel data from in vitro and clinical samples suggest the possibility that EMT is directly linked to CSCs and that Brachyury is a regulator of EMT and CSCs.

  11. [Postoperative radiation therapy in lung carcinom].

    Bouchaab, H; Peters, S; Ozsahin, M; Peguret, N; Gonzales, M; Lovis, A

    2014-05-21

    Locally advanced non-small-cell lung carcinoma (NSCLC) is a very heterogeous disease, the role of postoperative radiation therapy (PORT) in pN2 patients with completly resected NSCLC remains controversial. Although an improvment in local control has been described in several studies, the effect on survival has been contradictory or inconclusive. Retrospective evaluation suggest a positive effect of PORT in high risk patients with pN2 disease: RI-resected NSCLC, bulky and multilevel N2. However further evaluation of PORT in prospectively randomized studies in completely resected pN2 NSCLC is needed. PMID:24941680

  12. [Signet ring cell colorectal carcinom - case report].

    Matkovčík, Z; Hlad, J

    2015-08-01

    Signet ring cell colorectal carcinoma is a rare aggressive tumor. The incidence of this desease is very low in young patients and accounts up to 1% of all surgical patients with colorectal cancer. The infrequency of the disease among young patients makes the diagnosis more difficult and the prognosis less favourable. Biopsy results are crucial for verification of signet ring cell carcinoma. Treatment is similar as in other types of colorectal cancer. We report a case of signet ring cell colon cancer in a 22 years old female patient.The aim of this paper is to point out this rare case of infrequent colorectal cancer in a young female patient. PMID:26395957

  13. Carcinoma adenoescamoso do colo uterino mimetizando carcinoma adenóide basal: relato de um caso e revisão da literatura Adenosquamous carcinoma of the cervix mimicking adenoid basal carcinoma: case report and review of the literature

    Álvaro Piazzeta Pinto

    2007-02-01

    Full Text Available O carcinoma adenoescamoso do colo uterino é definido como um tumor que contém uma mistura de células malignas com diferenciação escamosa e glandular. A literatura salienta a importância de se fazer esse diagnóstico, uma vez que, quando os componentes não são bem diferenciados ou não se encontram evidentes na amostra analisada, esse tumor pode ser erroneamente interpretado como carcinoma escamoso ou adenocarcinoma. O presente trabalho descreve a apresentação pouco comum de um carcinoma adenoescamoso. Após sucessivos diagnósticos citológicos não concordantes e complicados por uma história de sangramento uterino anormal ocasionado por endometriose cervical, a paciente de 47 anos foi submetida a histerectomia total, obtendo diagnóstico definitivo. Esse particular tumor aqui relatado foi diagnosticado como carcinoma adenoescamoso, mas em muitos aspectos apresentou-se semelhante ao carcinoma adenóide basal. Elementos característicos do carcinoma adenóide basal, como presença de lesão intra-epitelial escamosa na superfície, diferenciação escamosa e glandular no centro dos blocos neoplásicos e células basalóides na profundidade da lesão, foram observados em nosso caso. Em contrapartida, os seguintes elementos normalmente não observados no carcinoma adenóide basal estavam presentes: atipias e figuras de mitose nas células indiferenciadas da profundidade do tumor e lesão intra-epitelial escamomucinosa (SMILE na superfície. Fatores epidemiológicos e clínicos, como idade (47, raça (branca e forma de apresentação clínica (massa visível na inspeção cervical, também colaboraram para afastar esse diagnóstico diferencial. Outros diagnósticos diferenciais do carcinoma adenoescamoso do colo uterino incluem o carcinoma puramente escamoso ou glandular, o tumor de colisão e o adenocarcinoma de endométrio com diferenciação escamosa invadindo o colo uterino.Adenosquamous carcinoma of the uterine cervix is defined as a tumor that contains a mixture of malignant cells with squamous and glandular differentiation. The literature points to the importance of making this diagnosis when the cellular components are still well differentiated in the sample, otherwise the tumor may be erroneously interpreted as squamous carcinoma or adenocarcinoma. This study describes an unusual presentation of a adenosquamous carcinoma in a 47 year old patient. After conflicting cytological diagnoses and a history of abnormal uterine bleeding caused by cervical endometriosis, the patient was subjected to radical hysterectomy and a final diagnosis was obtained. The tumor was diagnosed as adenosquamous carcinoma. In many aspects, however, it was similar to the adenoid basal carcinoma. Characteristic features of the adenoid basal carcinoma such as the presence of high-grade squamous intraepithelial lesion in the surface epithelium, squamous and glandular differentiation in the center of the neoplastic mass, and basaloid cells in deep areas of the tumor were observed. Therefore, the following elements usually absent from adenoid basal carcinoma were present in this case: atypia and mitotic figures in undifferentiated cells, squamous-mucinous intraepithelial lesion (SMILE in the superficial areas. Epidemiological and clinical data, such as patient age (47, race (white and presentation (a cervical mass, concurred to exclude the diagnosis of adenoid basal carcinoma. Other differential diagnoses include pure squamous carcinoma or adenocarcinoma, collision tumor, and endometrial adenocarcinoma with squamous differentiation invading the uterine cervix.

  14. Avaliação da pressão inspiratória em crianças com aumento do volume de tonsilas Evaluation of inspiratory pressure in children with enlarged tonsils and adenoids

    Melissa Guerato Pires

    2005-10-01

    Full Text Available Crianças com aumento do volume de tonsilas palatina e faríngea freqüentemente apresentam anormalidades respiratórias tais como ronco, respiração oral e apnéia do sono. Sabe-se que a obstrução de vias aéreas superiores e conseqüentemente a respiração oral podem resultar em problemas pulmonares. OBJETIVO: Avaliar a pressão inspiratória em crianças com obstrução de vias aéreas superiores devido ao aumento do volume de tonsilas. FORMA DE ESTUDO: clínico com coorte transversal. MATERIAL E MÉTODO: Nós avaliamos 37 crianças (4-13 anos, ambos os sexos com aumento do volume de tonsilas que seriam submetidas à cirurgia de Adenoamigdalectomia na Divisão de Otorrinolaringologia da Universidade de São Paulo no mesmo período. O grupo controle foi composto de 28 crianças sem aumento de volume tonsilar que foram submetidas aos mesmos testes. A pressão Inspiratória foi obtida pelo uso do manovacuômetro. RESULTADOS: Observamos uma menor pressão inspiratória no grupo com aumento do volume de tonsilas. A média do grupo com aumento do volume das tonsilas foi 14,607 cm/H2O e do grupo normal foi de 27,580 cm/H2O (PChildren with enlarged tonsils and adenoids usually present breathing abnormalities such as snoring, mouth breathing and sleep apnea. It is known that upper airway obstruction and consequent mouth breathing may result in pulmonary diseases. AIM: The goal of this preliminary study was to evaluate the inspiratory pressure in children with upper airway obstruction due to enlarged tonsils. STUDY DESIGN: clinical with transversal cohort. MATERIAL AND METHOD: We evaluated 37 children (4 -13 years old, female/male with enlarged tonsils who would be submitted to a T&A surgery in the Department of Otolaryngology, Medical School, University of Sao Paulo, from October 2002 to March 2003. The control group comprised 28 children without tonsillar disease submitted to the same tests. Inspiratory pressure was obtained using a manometer and vacuum meter. RESULTS: We could observe lower inspiratory pressures in children with upper airway obstruction. The mean of inspiratory pressure in the upper airway obstruction group was 14.607cm/H2O and in the control group was of 27.580cm/H2O. CONCLUSIONS: Enlarged tonsils and adenoids were associated with poor inspiratory pressure, resulting in increased breathing effort and work of the involved muscles.

  15. Modalidad quirúrgica como alternativa en la otitis media serosa por hipertrofia adenoidea: Pinar del Río, 2008 An alternative surgical method in the serous otitis media due to adenoid hypertrophia: Pinar del Rio, 2008

    Fidel Castro Pérez

    2008-12-01

    Full Text Available La hipoacusia tiene repercusión negativa en el aprendizaje y comportamiento social de los niños, por lo que se hace necesaria la aplicación de técnicas quirúrgicas cada día más eficientes que reduzcan esta problemática. Con el objetivo de demostrar la eficacia de una nueva modalidad quirúrgica consistente en realizar adenoidectomía y doble miringotomía con aspiración del contenido seromucoso y de proponer una estrategia para solución quirúrgica definitiva en el nivel secundario y preventiva en el nivel primario, se realizó una investigación de innovación _ tecnológica, descriptiva, longitudinal prospectiva en niños con hipoacusia conductiva por otitis media serosa secundaria a hipertrofia adenoidea, que asistieron a las consultas de audiología del Hospital Pediátrico Provincial Docente" Pepe Portilla" y del Policlínico Universitario Dr." Ernesto Guevara" de Sandino. El universo estuvo constituido por todos los niños con hipoacusia conductiva registrados en consulta de audiología. La muestra resultó de 109 pacientes con hipoacusia por Otitis Media Serosa secundaria a Hipertrofia Adenoidea, provenientes de 10 municipios de nuestra provincia, entre los 4 y 12 años de edad; mediante muestreo intencional. A todos los pacientes se les realizó examen otorrinolaringológico y audiometría tonal. Se utilizaron métodos de encuesta, análisis documental y de la Estadística Descriptiva utilizando medidas de frecuencias absolutas y relativas porcentuales. Se calcularon intervalos de confianza para algunas de las frecuencias relativas buscadas y previo consentimiento informado se trataron quirúrgicamente, reevaluados en consulta, donde se comprobó que 108 pacientes evolucionaron satisfactoriamente, concluyendo que es una técnica eficaz.Hypoakusia has a negative repercussion in learning and social behaviour in children so it is mandatory the implementation of surgical techniques in order to minimize this condition.. A new descriptive longitudinal and prospective technique was performed in children suffering from conductive hypoakusia due to serous otitis media secondary to adenoid hypertrophia attending to the hearing care office at "Pepe Portilla"Pediatric Hospital and "Dr.Ernesto Guevara "Policlinic in Sandino in order to show the efficacy of a new definitive surgical technique (adenotomy and double miringotomy with aspiration of the seromucus content and to propose an strategy for a definitive surgical solution in the secondary level being preventive at primary level. Universe was comprised of all the children suffering from conductive hypoakusia who were recorded in the auditory care office, the sample had 109 patients coming from 10 municipalities of our province and suffering from hipoakusia due to serous otitis media secondary to adenoid hypertrophia, they were 4 and 12 year old. All the patients were given otolaringologic examinations and tonal audiometry. Survey methods, documental analisis and descriptive statistic method were applied using relative and absolute percentage frequency measurements.Confidence intervals for some relative frequencies and previous informed consent were estimated; patients were surgically treated and reevaluated at the office showing that 108 patients had a satisfactory natural history and concluding that it is an efficient technique.

  16. Inverse planned stereotactic intensity modulated radiotherapy (IMRT) in the treatment of incompletely and completely resected adenoid cystic carcinomas of the head and neck: initial clinical results and toxicity of treatment

    Presenting the initial clinical results in the treatment of complex shaped adenoid cystic carcinomas (ACC) of the head and neck region by inverse planned stereotactic IMRT. 25 patients with huge ACC in different areas of the head and neck were treated. At the time of radiotherapy two patients already suffered from distant metastases. A complete resection of the tumor was possible in only 4 patients. The remaining patients were incompletely resected (R2: 20; R1: 1). 21 patients received an integrated boost IMRT (IBRT), which allow the use of different single doses for different target volumes in one fraction. All patients were treated after inverse treatment planning and stereotactic target point localization. The mean folllow-up was 22.8 months (91 – 1490 days). According to Kaplan Meier the three year overall survival rate was 72%. 4 patients died caused by a systemic progression of the disease. The three-year recurrence free survival was according to Kaplan Meier in this group of patients 38%. 3 patients developed an in-field recurrence and 3 patient showed a metastasis in an adjacent lymph node of the head and neck region. One patient with an in-field recurrence and a patient with the lymph node recurrence could be re-treated by radiotherapy. Both patients are now controlled. Acute side effects >Grade II did only appear so far in a small number of patients. The inverse planned stereotactic IMRT is feasible in the treatment of ACC. By using IMRT, high control rates and low side effects could by achieved. Further evaluation concerning the long term follow-up is needed. Due to the technical advantage of IMRT this treatment modality should be used if a particle therapy is not available

  17. MRI of cystic collection of the three joint; Les collections kystiques du genou en IRM

    Boutry, N.; Cotten, A.; Dewatre, F.; Chastanet, P.; Gougeon, F. [Hopital R. Salengro, C.H.U., 59 - Lille (France)

    1997-09-01

    We present the main MR features of cystic lesions around the knee joint. Popliteal cysts are the most frequently seen. The usually result from extrusion of joint fluid into the gastrocnemio-semimembranosus bursa but they can have an atypical location or extension. They are most often due to a meniscal, ligamentous, degenerative or inflammatory joint disease responsible for a chronic joint effusion. Meniscal cysts are always associated with a horizontal tear. Medial meniscal cysts are larger and can extend far from the joint. Bursitis occur as a result of inflammation or infection of a bursa. Their location is stereotyped and they do not communicate with the knee joint. Ganglion cysts or ganglia are benign cystic lesions which can affect peri-articular tissues as well as subchondral bone or cruciate ligaments. MRI is now a simple and noninvasive way of obtaining etiologic diagnosis and guiding therapy. (authors). 46 refs.

  18. Tonsillectomy and Adenoids PostOp

    ... may be reluctant to eat because of throat pain; consequently, some weight loss may occur, which is gained back after a normal diet is resumed. Fever : A low-grade fever may be observed the night of the surgery and for a day or ...

  19. Tonsils and Adenoids PostOp

    ... may be reluctant to eat because of throat pain; consequently, some weight loss may occur, which is gained back after a normal diet is resumed. Fever : A low-grade fever may be observed the night of the surgery and for a day or ...

  20. P53 gene snp investigation in squamous cell oesophageal carcinom

    Catalina Luca; Laura Buburuzan; Dragos Romanescu; Codrut Stanescu; Simona Dima; Irinel Popescu; Vladimir Botnarius; Marieta Costache

    2010-01-01

    Squamous cell cancer (ESCC) and adenocarcinoma (EADC) are the two main subtypes of oesophageal cancer. Genetic alterations associated with the development of oesophageal cancer are often observed. The aim of this study was to identify p53 gene polymorphisms in several patients with oesophageal squamous cell carcinoma. Genomic DNA was isolated from normal-, tumor- and blood-samples from patients with ESCC. PCR amplification of two p53 gene fragments was performed using two sets of ...

  1. Moving irradiation in associated radiotherapy for uterine cervix carcinom;

    A technique and results of treatment of 399 patients with uterine cervix carcinoma by moving irradiation are described. Application of moving telegammatherapy permits to improve considerably spatial dose distribution and to increase a dose for parametrii. Radiation responses of neighbouring organs are described as well. Moving telegammatherapy is recommended as a component of combined radiotherapy of uterine cervix carcinoma

  2. Carcinome épidermoide du pénis

    Naim, Asmaa; Zakouri, Fatim-Zahra

    2016-01-01

    Penile tumors are the rarest male urogenital tract tumors (1%). Squamous cell carcinoma is the most common histologic type (95%). Radical surgical excision, though often mutilating, remains the best treatment for localized stages, in terms of local control (6% local recurrence). There are other therapeutic weapons and their possible indications should be adapted to the locoregional extension and at a distance from the primary tumor. We report the case of Mr AS aged 61, without particular pathological antecedents, who consulted, 6 years before, for an ulcerated burgeoning in the anterior surface of the penile bleeding on contact, which extended along the penis, without involving the glans penis. Evolution was marked by tumor progression with extension to the anterior pelvic wall. The patient went into a critical state of hemorrhagic shock. After stabilizing the hemodynamic status, a biopsy of the penis lesion confirmed the diagnosis of well-differentiated squamous cell carcinoma. An evaluation of the extent of loco-regional recurrence and distant metastasis showed pulmonary micronodules in the right lung. The case was discussed at the Multidisciplinary Consultative Meeting and patient was deemed inoperable and offered palliative chemotherapy. The prognosis of advanced stages of penis cancer is reserved; their frequency in our context is related to the modesty of patients, which explains the causes of delay in medical examination. Only socio-cultural awareness allows early diagnosis and, therefore, a better prognosis.

  3. Bacteremia during adenoidectomy: a comparison of suction diathermy adenoid ablation and adenoid curettage.

    Casserly, Paula

    2010-08-01

    Transient bacteremia is induced by adenoidectomy when the integrity of the nasopharyngeal membrane is broken. The aim of this study was to determine the incidence of bacteremia in patients undergoing adenoidectomy, to identify the causative organisms, and to compare the incidences of bacteremia between the two techniques suction diathermy and curettage.

  4. Montelukast in Adenoid Hypertrophy: Its Effect on Size and Symptoms

    Shokouhi, Farshid; Meymaneh Jahromi, Ahmad; Majidi, Mohamad Reza; Salehi, Maryam

    2015-01-01

    Introduction: Adenotonsillar hypertrophy (AH) is considered the most common cause of upper respiratory tract obstruction among children. It results in a spectrum of symptoms from mouth breathing, nasal obstruction, hyponasal speech, snoring, and obstructive sleep apnea (OSA) to growth failure and cardiovascular morbidity. Adenotonsillectomy is a typical strategy for patients with AH, but may lead to serious complications such as bleeding (4–5%) and postoperative respiratory compromise (27%), ...

  5. A diagnosis pitfall: the cystic bilateral pheochromocytoma. Discussion of a case; Un piege diagnostique: le pheocromocytome bilateral kystique. A propos d`un cas

    Devillers, A.; Bedig, G.; Garin, E.; Bouyaux, M.; Lecloirec, J. [CHG St Brieuc CRLCC Eugene Marquis Rennes (France)

    1997-12-31

    We report here the clinical history of Mrs A. (37 years old). On November 1995 Mrs A. presents stereotypical paroxysmal (2 to 3 / month) strokes of type of sensation of fast palpitations followed by very intense cephalies and sweats. The hypothesis of a pheochromocytoma has been retained, confirmed by a very important increase in the urinary metanephrines and normetanephrines and of noradrenaline. The abdominal scanner evidenced a left supra-renal tumoral lesion and also a voluminous right-renal cyst overflowing the right supra-renal. In May 1996 Mrs A. benefited by a left supra-renal-ectomy which confirmed histologically a benign pheochromocytoma. Long after the intervention the patient is totally asymptomatic but the metanephrines remains high (3000 {mu} g/24 h). The scanner applied in December 1996 finds only the voluminous right-renal cyst formation which perturbs the supra-renal exploration and rises questions about relic thymus. A scintigraphy by MIBG-{sup 131}I evidenced on the images after 24 h a hyper-fixation with hepatic projections seeming to circumscribe a voluminous right-supra-renal lacuna, confirmed by injection of 20 mCi of pertechnetate, while at 48 h this image reinforces. The diagnosis of a cystized left pheochromocytoma was established while the thymus region was normal. A scintigraphy with somatostatin labelled by indium 111 finds the anomalies superimposed on those obtained by MIBG. The patient was operated in May 1997 and a diagnosis was histologically confirmed. In conclusion, the scintigraphy by MIBG {sup 131}I must be part in the examination for suspicion of pheochromocytoma and must be interpreted together with the TDM morphological data

  6. Image Processing for Morphological Investigation of the Carcinome Thyroid Gland: Modern Facilities

    Nedzved, A.; Fridman, M.; Belotserkovsky, A.

    2009-01-01

    This paper describes automation methods for diagnostics of the thyroids gland carcinoma. It based on image processing technology and calculation of characteristics from image. Methods are used for investigation of histological samples.

  7. Sorafenib and radiotherapy association for hepatocellular carcinoma; Sorafenib et radiotherapie dans le carcinome hepatocellulaire

    Girard, N. [Service de pneumologie, hopital Louis-Pradel, hospices Civils de Lyon, 28, avenue du Doyen-Jean-Lepine, 69500 Bron (France); UMR 754, universite Claude-Bernard Lyon 1, 43, boulevard du 11-novembre-1918, 69622 Villeurbanne cedex (France); Mornex, F. [UMR 754, universite Claude-Bernard Lyon 1, 43, boulevard du 11-novembre-1918, 69622 Villeurbanne cedex (France); Departement de radiotherapie-oncologie, centre hospitalier Lyon Sud, 165, chemin du Grand-Revoyet, 69495 Pierre-Benite cedex (France)

    2011-02-15

    Conformal radiotherapy is a promising therapeutic strategy for hepatocellular carcinoma (HCC), producing local control rates above 90% within the radiation beam. However, survival after radiotherapy remains limited by the high frequency of intra- and extra-hepatic recurrences, which occurs in 40-50 and 20-30% of cases, respectively. Sorafenib (BAY43-9006, Nexavar; Bayer, West Haven, CT) is a small molecule inhibitor that demonstrated potent activity to target v-raf murine sarcoma oncogene homologue B1 (BRAF) and VEGFR tyrosine kinases. Sorafenib is the only drug that demonstrated effectiveness to increase overall survival in advanced or metastatic hepatocellular carcinoma. The rationale to combine radiotherapy with sorafenib is the following: (1) targeting RAS-RAF-MAPK and VEGFR signaling pathways, which are specifically activated after exposure to radiation, and responsible for radio-resistance phenomenon; (2) enhancing the oxygen effect through normalization of the surviving tumor vasculature; and (3) synchronization of the cell cycle. Sorafenib and radiotherapy represent complementary strategies, as radiotherapy may be useful to prolong the effect of sorafenib through control of the macroscopic disease, when sorafenib may target latent microscopic disease. Sorafenib and radiotherapy associations are thus based on a relevant biological and clinical rationale and are being evaluated in ongoing phase I-II trials. (authors)

  8. Non-surgical management of hepatocellular carcinoma; Prise en charge non chirurgicale du carcinome hepatocellulaire

    Merle, P. [Service d' hepato-gastroenterologie, hopital de l' Hotel-Dieu, 69 - Lyon (France); Inserm U871 -Oncogenese hepatique et hepatites virales-, 69 - Lyon (France); IFR62 Lyon-Est, universite Lyon 1, 69 - Lyon (France); Mornex, F. [Departement de radiotherapie-oncologie, centre hospitalier Lyon-Sud, 69 - Pierre-Benite (France)

    2010-10-15

    Most of patients with hepatocellular carcinoma (HCC) cannot benefit from surgical therapies. Among non-surgical options, only radiofrequency can challenge surgery for small size tumours. Conformal radiotherapy is likely highly efficient on solitary tumours, but controlled studies are warranted to conclude. Other options are purely palliative. Trans-arterial hepatic chemo-embolization is the goal-standard for multifocal hepatocellular carcinoma and Sorafenib for hepatocellular carcinoma with portal vein invasion, leading to modest but significant benefit on survival rates. Yttrium-90 radio-embolization is under evaluation through controlled studies, and could be of major interest for multifocal hepatocellular carcinoma with or without portal venous invasion. (authors)

  9. Pemphigoïde bulleuse révélant un carcinome bronchique

    Janah, Hicham; Mahhou, Meryem; Souhi, Hicham; Zegmout, Adil; Naji-Amrani, Hicham; Raoufi, Mohamed; Elouazzani, Hanane; Rhorfi, Ismail Abderrahmani; Abid, Ahmed

    2014-01-01

    La pemphigoïde bulleuse (PB) est la plus fréquente des dermatoses bulleuses auto-immunes, touchants préférentiellement le sujet âgé de plus de 70 ans. L'origine paranéoplasique de La PB est rarement rapportée. Cette lésion peut apparaitre de manière synchrone ou parfois être une manifestation révélatrice de la tumeur. Nous rapportons l'observation d'un jeune patient présentant un cancer bronchique métastatique révélé par une PB. Chez le sujet jeune fumeur, toute pemphigoïde bulleuse justifie ...

  10. Carcinom of the paranasal sinuses--a review of 158 cases.

    Bridger, M W; Beale, F A; Bryce, D P

    1978-10-01

    One hundred and fifty-eight cases of paranasal sinus cancer have been reviewed retrospectively. The actuarial survival at five years for the whole group was 33%. The American Joint Committee (AJC) classification for maxillary cancer was used. T1 and T2 cases, with an actuarial survival of 44% at five years, had a significantly better prognosis than T3 cases (31%) and T4 cases (10%). Anemia of presentation and the presence of persistent disease when surgery followed pre-operative irradiation were poor prognostic indicators. The policy of combined pre-operative irradiation followed by surgery is advocated; patients with anemia should have this corrected before and during treatment. PMID:105151

  11. Skeleton scintigraphy and radiologic data at 403 patients with prostata carcinom

    In a retrospective study 403 patients with prostatic carcinoma (PC) were examined to shed light on the relation between the rate of metastases and the stage of local tumor spread as well as the histomorphologic tumor type; to establish the rate of metastases detected by bone scanning versus radiology; and to compare the contributions of bone scanning versus radiology in monitoring the response of bone metastases to treatment. Results: (1) The rate of metastases was found to increase as a function of primary tumor size and increasing dedifferentiation; however, bone metastases were also seen in highly differentiated stage O and A PC. (2) Solitary metastases were confined to the pelvic bones and lumbar vertebrae. (3) About one third of all bone metastases were radiologically silent; in sporadic cases receiving contrasexual therapy they remained silent for more than 5 years. (4) Bone scnaning showed 73.3% of patients to respond to contrasexual therapy and 26.7% to be non- responders. (6) There were some differences or even discrepancies between bone scans and radiology in documenting the results of treatment. Conclusions: Repeated bone scans are required for monitoring the course of the disease even if the primary tumor is extremely small and histologically well differentiated. Bone scans are superior to radiology in detecting metastases. While repeat X-rays during the course of a disease furnish important information, they are unsuited for monitoring the response to treatment. (Author)

  12. Thyroid carcinoma, hyperthyroidism and iodine intake; Carcinome thyroidien, hyperthyroidie et apport iode

    Als, C.; Netzer, P.; Gedeon, P.; Glaser, C.; Seiler, C.; Markwalder, R.; Laissue, J.; Roesler, H. [Universite de Berne, Berne (Switzerland)

    1997-12-31

    The absolute iodine intake, slowly ameliorated, in a population influences the epidemiology of thyroid carcinoma (TC) and of hyperthyroidism (HT). We have retrospectively evaluated the frequencies of associated TC and HT in a pre-Alpine region over a period amounting up to more than 30 years. The iodide salt (5 - 10 - 20 mg KI/kg since 1922 - 1962 - 1980) have progressively corrected the severe iodine deficit, prevailing at the beginning of century. The patients treated for TC by surgery and/or {sup *}I in our hospital have been grouped in 3 periods: A (before 1971), B (1971 - 1983) and C (1984 - 1996), according to the diagnosis of malignity. Recorded were the number/type of associated TC (histology/or cytology) and HT (blood/clinic/scintigraphy by {sup *}I dosages). (GB = disease of Graves-Basedow, UFA/MFA = HT by uni- or multifocal functional autonomy, FC = follicular C, PC = papillary C, AC anaplas.C). On 925 TC, the FC has fallen from 64% down to 32%, the TC increased from 25% up to 60%, while the AC and other different C were of stable frequencies. The low frequency of AC has remained stable and it was not associated to HT. The associated HT (n = 97) were UFA in 60% to 13%, MFA (around {+-} 30%) and GB in 10% to 40% of cases. In conclusion, at 70 years since its introduction, the effect of iodide salt remains beneficent. Actually, the epidemiologic evolution described in 1963 by Walthard maintains. Due to the continues slope down of FC and up of PC in Berne during the period 1945 -1996 the general prognostication of TC continues to improve 16 years after the last augmentation of iodine in salt in Switzerland. The general decrease of UFA following the major correction of iodine deficit explains its less frequent association with the TC

  13. Small bowel obstruction caused by peritoneal immunoglobulin G4-related disease mimicking carcinomators: Case report

    We hereby report a case of diffuse pelvic peritoneal involvement by immunoglobulin G4-related disease (IgG4-RD). Numerous pelvic masses and nodules showing delayed enhancement on enhanced abdominal CT were found to congregate in the pelvic organs of a 57-year-old female presenting with intestinal subocclusion. The differentiation between peritoneal IgG4-RD and pelvic peritoneal carcinomatosis was only made by histopathology and immunohistochemistry performed after surgical resection. Autoimmune pancreatitis represents the historical prototype of IgG4-RD, but the spectrum of manifestations involving various organs has expanded during the last decade. In this report, we shortly review this clinical entity.

  14. Irradiation of low rectal cancers; Radiotherapie des carcinomes du bas rectum

    Ardiet, J.M.; Coquard, R.; Romestaing, P.; Fric, D.; Baron, M.H.; Rocher, F.P.; Sentenac, I.; Gerard, J.P. [Centre Hospitalier Lyon-Sud, 69 -Pierre-Benite (France)

    1994-12-31

    The low rectal cancers are treated by anorectal amputation and pose the problem of the sphincter conservation. Some authors extend the clinical definition to developed injuries until 12 cm from the anal margin. The rectal cancer is a frequent tumour which remains serious. When the tumour is low, the treatment consists in an anorectal amputation with a permanent colostomy. The radical non preserving surgery is the usual treatment of these injuries. Until 1960 the rectal adenocarcinoma was considered as a radioresistant tumour because of the impossibility to deliver an enough dose to the tumour by external radiotherapy. But other studies showed that those lesions were radiosensitive and often radiocurable. The medical treatments haven`t yet demonstrated their efficiency in the treatment of the rectal cancer. We`ll study the radiotherapy in the treatment of the low rectal cancer, solely radiotherapy, radiosurgical associations. 32 refs., 5 tabs.

  15. Late neurotoxicity after nasopharyngeal carcinoma treatment;Toxicite neurologique tardive apres traitement des carcinomes nasopharynges

    Siala, W.; Mnejja, W.; Daoud, J. [Hopital Habib-Bourguiba, Service de Radiotherapie Carcinologique, Sfax (Tunisia); Khabir, A.; Boudawara, T. [Hopital Habib-Bourguiba, Service d' Anatomopathologie, Sfax (Tunisia); Ben Mahfoudh, K. [Hopital Habib-Bourguiba, Service de Radiologie, Sfax (Tunisia); Ghorbel, A. [Hopital Habib-Bourguiba, Service d' ORL, Sfax (Tunisia); Frikha, M. [Hopital Habib-Bourguiba, Service de Carcinologie Medicale, Sfax (Tunisia)

    2009-12-15

    Purpose A retrospective analysis of risk factors for late neurological toxicity after nasopharyngeal carcinoma radiotherapy. Patients and methods Between 1993 and 2004, 239 patients with non metastatic nasopharyngeal carcinoma were treated by radiotherapy associated or not to chemotherapy. Radiotherapy was delivered with two modalities: hyperfractionated for 82 patients and conventional fractionation for 157 patients. We evaluated the impact of tumour stage, age, gender, radiotherapy schedule and chemotherapy on neurological toxicity. Results After a mean follow-up of 107 months (35-176 months), 21 patients (8.8%) developed neurological complications, such as temporal necrosis in nine cases, brain stem necrosis in five cases, optics nerve atrophy in two cases and myelitis in one case. Five- and ten-year free of toxicity survival was 95 and 84% respectively. Young patients had greater risk of temporal necrosis, and hyperfractionated radiotherapy was associated with a significantly higher risk of neurological complications (14.6% vs 5.7%, p = 0.02). On multivariate analysis, hyperfractionation and age were insignificant. Conclusion Late neurological toxicity after radiotherapy for nasopharyngeal carcinoma was rare. Younger age and hyperfractionation were considered as risk factors of neurological toxicity in our study

  16. Small bowel obstruction caused by peritoneal immunoglobulin G4-related disease mimicking carcinomators: Case report

    Coulier, Bruno; Montfort, Luc; Pierard, Frederic [Clinique St. Luc, Bouge (Belgium); Beniuga, Gabrique; Gielen, Lsabelle [Institute of Pathology and Genetics, Gosselies (Belgium)

    2014-02-15

    We hereby report a case of diffuse pelvic peritoneal involvement by immunoglobulin G4-related disease (IgG4-RD). Numerous pelvic masses and nodules showing delayed enhancement on enhanced abdominal CT were found to congregate in the pelvic organs of a 57-year-old female presenting with intestinal subocclusion. The differentiation between peritoneal IgG4-RD and pelvic peritoneal carcinomatosis was only made by histopathology and immunohistochemistry performed after surgical resection. Autoimmune pancreatitis represents the historical prototype of IgG4-RD, but the spectrum of manifestations involving various organs has expanded during the last decade. In this report, we shortly review this clinical entity.

  17. The expression of aquaporin 1 in renal cell carcinomal before and after interventional treatment and its significance

    Objective: To evaluate the effect of interventional treatment on the expression level and distribution of aquaporin 1 (AQP1) in renal cell carcinoma and its significance. Methods: Fifteen cases of renal cell carcinoma tissues which received chemotherapy embolism before nephrectomy and 12 cases of renal cell carcinoma tissues which only had nephrectomy were studied as test group. Twelve cases of normal kidney tissues were studied as control groups. RT-PCR, western blot analysis and immunohistochemical method were performed to detect the expression of AQP1 on different tissues. Results: In normal kidney tissues, AQP1 expressed in the capillary endothelia cells of glomerulus, epithelial cell of proximal tubules. In renal cell carcinoma tissues, AQP1 expressed in tumor cells and epithelial cells of capillary vessel. Expression of AQP1 remarkably decreased in renal cell carcinoma tissues compared with normal kidney tissues (Pixel intensity rate of AQP1 and ?-actin by RT-PCR methods were 0.935 and 0.855 respectively; AQP1 positive pixel intensity by western blot methods were 125.8 and 147.4 respectively; positive index of AQP1 pixel intensity by immunohistochemical method were 1.31 and 1.08, P<0.01). Expression of AQP1 remarkably decreased in renal cell carcinoma tissues which received chemotherapy embolism compared with renal cell carcinoma which only had nephrectomy (Pixel intensity rate of AQP1 and ?-actin by RT-PCR methods was 0.810; AQP1 positive pixel intensity by western blot methods was 159.7; positive index of AQP1 pixel intensity by immunohistochemical method was 0.82, P<0.05). Conclusion: Interventional treatment can depress the expression of AQP1 in renal cell carcinoma and suppress the growth and metastasis of renal cell carcinoma. (authors)

  18. Reirradiation by Cyberknife of head and neck carcinomas; Reirradiation par Cyberknife de carcinomes de la tete et du cou

    Balajouza Kanoun, S.; Lacornirie, T.; Coche Dequeant, B.; Mirabel, X.; Lefebvre, J.L.; Lartigau, E. [Centre Oscar-Lambret, Univ. de Lille-2, Dept. Universitaire de Radiotherapie, 59 - Lille (France)

    2007-11-15

    In spite of local treatment the local defeat is a problem in O.R.L. cancerology. It has been demonstrated that some recurrences or second cancers in beforehand irradiated area could be sterilized by a new irradiation of high dose after perfect definition of the volume to treat and the certainty that recurrence will be localized.Numerous works have allowed to underline that a part of patients, with an O.R.L. recurrence can be treated again with curative aim with survival rate about 20 to 20 % at three years. The objective of this study was to test with a phase two study, the validation of a stereotaxic type reirradiation by Cyberknife associated to Cetuximab. (N.C.)

  19. Un faux kyste pancréatique mimant une tumeur kystique et doublement compliqué de compression digestive et d'hémorragie: la pancréatite aiguë, la saga continue

    Ameuraoui, Taoufiq; Alami, Baderedine; Boubbou, Meryem; Maaroufi, Mustapha; Kamaoui, Imane; Tizniti, Siham

    2014-01-01

    L'histoire naturelle des pancréatites aigues nécrotico-hémorragiques est parfois caractérisée par la survenue imprévisible de plusieurs complications. La formation de pseudos kystes constitue un tournant évolutif important lors de sa survenue. Son évolution est imprévisible pouvant aller de la simple résorption spontanée à la survenue de complications gravissimes. Les principales complications observées sont l'obstruction, la surinfection et l'hémorragie. Nous rapportons le cas d'une pancréat...

  20. Inoperable metastatic giant basal cell trunk carcinoma: radiotherapy can be useful; Carcinome basocellulaire geant du tronc metastatique inoperable: la radiotherapie peut etre utile

    Mania, A.; Durando, X.; Lapeyre, M. [Centre Jean-Perrin, Clermont-Ferrand (France); Barthelemy, I. [CHU Estaing, Clermont-Ferrand (France)

    2011-10-15

    The authors evoke some characteristics of the basal cell carcinoma (slow evolution, local morbidity) and report and discuss the case of a giant basal cell trunk carcinoma, associated with several symptoms (pain, bleeding, anaemia), already metastatic at the moment of diagnosis, and locally treated by irradiation. Due to its size and expansion, this carcinoma was considered as inoperable. An external radiotherapy has been performed and resulted in a significant clinical tumour reduction. But the metastatic risk is high in such cases. Radiotherapy is then a therapeutic option for a local treatment with a durable efficiency. Short communication

  1. Nasopharynx carcinomas. about 1342 cases treated at Oran, Algeria; Carcinomes du nasopharynx. A propos de 1342 cas traites a Oran, Algerie

    Khaldi, H.; Aid, M.; Lahmer, K.; Dali-Youcef, A.F. [Radiotherapie, Oran (Algeria)

    2009-10-15

    The purpose was to describe the epidemiology, clinical and therapy characteristics of the cavum cancer and the different post therapy results. The cavum cancer is frequent in west Algeria. It is the first cancer of superior aero digestive tracts, the fifth one fro man and the seventh for woman. It represents 8% of the whole of cancers treated at the radiotherapy service in Oran. It is chemosensitive and can be cured by radiotherapy but the frequency of locoregional recurrences and metastases remains high, despite all therapeutic methods used. (N.C.)

  2. Trans-arterial chemo-embolization and conformal radiotherapy for hepatocellular carcinoma; Chimioembolisation et radiotherapie de conformation dans le traitement du carcinome hepatocellulaire

    Merle, P. [Service d' hepatogastroenterologie, hopital de l' Hotel-dieu, 1, place de l' Hopital, 69002 Lyon (France); Inserm U871, equipe ' Oncogenese hepatique et hepatites virales' , 151, cours Albert-Thomas, 69003 Lyon (France); Universite Claude-Bernard Lyon 1, IFR62 Lyon-Est, 8, avenue Rockefeller, 69008 Lyon (France); Mornex, F. [Departement de radiotherapie-oncologie, centre hospitalier Lyon-Sud, chemin du Grand-Revoyet, 69310 Pierre-Benite (France); equipe ' Ciblage therapeutique par les agents physiques' , EA 37-38, universite Claude-Bernard Lyon 1, 43, boulevard du 11-Novembre-1918, 69622 Villeurbanne cedex (France)

    2011-02-15

    Hepatocellular carcinoma is a poor prognosis tumour. The potential curative therapeutic options are ortho-topic liver transplantation, surgical resection and radiofrequency ablation. Unfortunately, only a minority of patients (around 20%) are eligible for these techniques. Thus, patients can benefit from palliative options, such as trans-arterial chemo-embolization (TACE) or sorafenib that bring only modest benefit on survival. Conformal radiotherapy allows delivering high dose radiation within a precise tumour volume while sparing the surrounding liver parenchyma. As employed in mono-therapy, conformal radiotherapy is highly efficient for small size hepatocellular carcinoma (< 5 cm). Above 5 cm, its efficacy is more limited but its association with TACE gives spectacular rates of complete responses. Controlled phase 2 or 3 trials are urgently warranted to define its indications in the therapeutic algorithm of hepatocellular carcinoma. (authors)

  3. COMPARISON AND EVALUATION OF VALUE OF THYROGLOBULIN LEVEL IN SERUM AND 1-131 WHOLE BODY SCAN (1-131 WBS) IN PATIENTS WITH DIFFERENTIATED THYROID CARCINOM

    Vakili, A.; A.Fard . H. Mohadesi M. Eftekhari; M. SAGHARI

    1998-01-01

    This study was done in research institute of nuclear medicine from 1988-1992 for evaluation of the value of serum thyroglobulin level in comparison with 1-131 whole body scan (1-131 WBS) in patients with differentiated thyroid carcinoma. 204 patients who had total or near total thyroidectomy treated with 1-131 were evaluated in this study. Out of 204 patients 136 did not have regional or distant metastases. 68 patients had recurrence and metastases in which 42 cases showed good correlation be...

  4. Pseudo-angiomatous liver metastasis of thyroid medullary carcinoma: multimodality diagnostic approach; Metastase hepatique pseudoangiomateuse d'un carcinome medullaire de la thyroide: approche diagnostique multimodalite

    Imperiale, A.; Keomany, J.; Rust, E.; Constantinesco, A. [CHU de Strasbourg, Service de biophysique et medecine nucleaire, 67 (France); Greget, M. [CHU de Strasbourg, Service de radiologie 1, 67 (France); Chabrier, G.; Goichot, B. [CHU de Strasbourg, Service de medecine interne, endocrinologie et nutrition, 67 (France); Detour, J. [CHU de Strasbourg, Service de radiopharmacie, 67 (France); Pessaux, P. [CHU de Strasbourg, Service de chirurgie generale, hepatique et endocrinienne, 67 (France)

    2010-07-01

    Purpose: Illustrate the result of the diagnosis by multimodality imaging (MRI, scintigraphy {sup 123}I-Mibg, PET/CT{sup 18}F-F.D.G. and {sup 18}F-F DOPA) with liver metastasis looking like a single angioma in a patient with atypical medullary thyroid carcinoma. Conclusions: Angiomas must be taken into account in the differential diagnosis of liver metastasis of endocrine tumors, particularly in the case of small injuries where it may be difficult to differentiate a peripheral nodular contrast enhancement of a globular enhancement characteristics of angiomas. (N.C.)

  5. Radiotherapy of maxillary sinuses carcinoma: state of art; Radiotherapie des carcinomes des sinus maxillaires: l'etat de l'art

    Chargari, C.; Bauduceau, O.; Vedrine, L.; Fayolle, M.; Ceccaldi, B. [Hopital d' Instruction des Armees Val-de-Grace, Service d' Oncologie Radiotherapie, 75 - Paris (France); Chargari, C.; Magne, N. [Institut Gustave-Roussy, Dept. de Radiotherapie, 94 - Villejuif (France); Haen, P. [Hopital d' Instruction des Armees Begin, Service de Chirurgie Maxillofaciale et Plastique de la Face, 94 - Vincennes (France); Conessa, C. [Hopital d' Instruction des Armees Val-de-Grace, Clinique d' Otorhinolaryngologie et de Chirurgie Cervicofaciale, 75 - Paris (France)

    2009-06-15

    Maxillary sinus carcinomas are rare malignancies of the face, characterized by high local relapsing rate. Modalities of treatment are without consensus and respective roles of radiation therapy and surgery remain controversial. As those malignancies are often diagnosed at locally advanced stage, radiation therapy may frequently be used for patients having unresectable advanced disease. Nevertheless, surgery remains treatment of choice for more localized malignancies, in association with systematic postoperative radiotherapy. For those patients whose prognosis remains pejorative, it is necessary to precise the role of radiotherapy in first intention for inoperable tumors, to define necessity for nodal treatment performing and evaluate the place of neo-adjuvant or concomitant chemotherapy in a multimodal strategy. (authors)

  6. Choanal stenosis: a rare complication of radiotherapy for nasopharyngeal carcinoma; Stenose choanale post-radique: une complication rare de la radiotherapie des carcinomes nasopharynges

    Bonfils, P.; Preobrajenski, N. de [Universite Rene-Descartes, Hopital Europeen Georges-Pompidou, Service d' ORL et de Chirurgie Cervicofaciale, Faculte de Medecine Paris-Descartes, 75 - Paris (France); Florent, A. [Cabinet d' ORL, 75 - Paris (France); Bensimon, J.L. [Cabinet de radiologie, 75 - Paris (France)

    2007-05-15

    Choanal stenosis is usually a congenital anomaly in children. Acquired choanal stenosis after radiotherapy for nasopharyngeal carcinoma is a very rare pathology; only two publications report seven cases in the literature. We describe the clinical history, preoperative evaluation, surgical treatment and outcome of a case of acquired choanal stenosis after radiotherapy. The patient, a 56-year-old woman, presented with a history of nasopharyngeal carcinoma (T2- NO-MO) one year before that had been successful treated with radiotherapy (68 Gy). At the end of radiotherapy, she complained of complete nasal obstruction, anosmia and hearing loss due to a bilateral serous otitis media. Bilateral complete choanal stenosis was confirmed by endoscopy and CT scan. Functional endoscopic surgery was performed, and nasal stents were left in place for 3 weeks. One year after, the patient have good airflow, and a patent nasopharynx without choanal stenosis. In conclusion, choanal stenosis is an unusual complication of radiotherapy that can be successfully treated with trans-nasal endoscopic resection. (authors)

  7. Chemoradiotherapy in head and neck squamous cell carcinoma: focus on targeted therapies; La chimioradiotherapie des carcinomes epidermoides des voies aerodigestives superieures: point sur les therapeutiques ciblees

    Bozec, A. [Centre Antoine-Lacassagne, Dept. de Chirurgie, Institut Universitaire de la Face et du Cou, 06 - Nice (France); Thariat, J.; Bensadoun, R.J. [Centre Antoine-Lacassagne, Dept. de Radiotherapie, Institut Universitaire de la Face et du Cou, 06 - Nice (France); Milano, G. [Centre Antoine-Lacassagne, Unite d' Oncopharmacologie, Institut Universitaire de la Face et du Cou, 06 - Nice (France)

    2008-01-15

    Radiotherapy is an essential treatment for many patients with head and neck squamous cell carcinoma. Its association with molecular targeted therapies represents a real progress. Among the recent advances in the molecular targeted therapy of cancer, the applications centred on E.G.F.R. are currently the most promising and the most advanced at clinical level. Considering the set of therapeutic tools targeting E.G.F.R., there are at present two well-identified emerging categories of drugs with monoclonal antibodies, on the one hand, and tyrosine kinase inhibitors, on the other. In many preclinical studies, the combination of anti-E.G.F.R. drugs with irradiation has led to additive or supra-additive cytotoxic effects. Furthermore, anti-angiogenic agents have shown promising results in association with anti-E.G.F.R. drugs and radiotherapy. This research effort has recently produced encouraging clinical results in advanced head and neck cancer with combination of cetuximab (an anti-E.G.F.R. monoclonal antibody) with irradiation with a significant impact on patient survival. Active and efficient clinical research is currently ongoing to determine the place of molecular targeted therapies in the treatment of head and neck cancer, particularly in association with radiotherapy. (authors)

  8. Carcinoma adenóide cístico: relato de caso = Adenoid cystic carcinoma: case report

    Palmeiro, Mariana Reuter et al.

    2005-01-01

    Full Text Available O carcinoma adenóide cístico é uma neoplasia maligna rara de crescimento lento, caracterizado prognóstico reservado, devido a sua agressividade e grande potencial recidivante. A lesão é mais prevalente em pacientes na faixa etária entre 50 e 70 anos, sendo incomum em jovens. O artigo relata um caso de carcinoma adenóide cístico de glândulas salivares menores localizado no palato duro em pacientes com 26 ano, do sexo masculino que foi encaminhado para tratamento no Serviço de Cirurgia de Cabeça e Pescoço.

  9. Postoperative Adjuvant Radiotherapy for Adenoid Cystic Carcinoma of the Head and Neck: Treatment Results and Prognostic Factors.

    Hsuan-Chih Hsu

    2003-09-01

    Full Text Available Background: To analyze the treatment results and prognostic factors of patients with adenoidcystic carcinoma (ACC arising from the major and minor salivaryglands of the head and neck, and who received postoperative radiotherapyafter radical tumor resection.Methods: Between October 1987 and December 1999, 25 patients with ACC of thehead and neck were treated with radical surgical resection and postoperativeadjuvant irradiation without chemotherapy. Using appropriate radiation techniquesto the tumor bed, total doses ranged from 44 to 68.4 Gy. All patientshad a minimum of 2 years of follow-up.Results: The 5-year overall survival rate, local control rate, and distant metastasis-freerate were 75%, 83%, and 66%, respectively. To the present, 2 patients hadexperienced recurrence at the primary sites, and 1 had regional lymph nodemetastasis. Distant metastases developed in 7 patients (28%, of whom 6(86% were disease-free at the primary site. The lung was the most commondistant metastatic site. In multivariate analysis, the only statistically significantprognostic factor for a distant metastasis-free rate was the stage at presentation( p = 0.009.Conclusion: Patients with an advanced stage of disease had higher distant metastasis rateseven when receiving postoperative radiotherapy. Distant metastasis is stillthe main problem in the management of ACC of the head and neck.However, more-effective treatment for this problem is still lacking.

  10. Tumores de tráquea: un caso de carcinoma adenoideo quístico Tracheal tumors: a case of adenoidal cystic carcinoma

    Glenis Madrigal Batista

    2006-03-01

    Full Text Available Los tumores de la tráquea son poco frecuentes y entre ellos el carcinoma adenoideo quístico es una neoplasia muy rara. La incidencia no difiere según el sexo y es más frecuente entre la tercera y quinta décadas de la vida. El tratamiento de elección es el quirúrgico, siempre que se trate de tumores resecables. Con este trabajo presentamos un caso intervenido por un tumor traqueal infrecuente, en una mujer con un carcinoma adenoideo quístico del tercio superior de la tráquea, con bordes de sección libres de tumor, que no recibió tratamiento oncológico

  11. Retrospective study of the local control and the cosmetic result of 147 face carcinomas after interstitial brachytherapy; Etude retrospective du controle local et du resultat cosmetique de 147 carcinomes de la face apres curietherapie interstitielle

    Ducassou, A.; David, I.; Bonnet, J.; Delannes, M. [Institut Claudius-Regaud, Service de Radiotherapie, 31 - Toulouse (France)

    2009-10-15

    The purpose was to evaluate retrospectively the local control rate and the cosmetic results for patients that received an interstitial brachytherapy for a base or spino-cellular carcinoma of face orifices areas. The interstitial brachytherapy by iridium 192 is an excellent alternative to surgery in the skin carcinomas of the face, as well at the level of local control as the cosmetic and functional results. (N.C.)

  12. Sentinel lymph node detection in oropharynx and oral cavity; Interet de la detection du ganglion sentinelle dans les carcinomes epidermoides de la cavite buccale et de l'oropharynx

    Chesnay, E.; Bouvard, G. [Centre Hospitalier Universitaire, Service de Medecine Nucleaire, 14 - Caen (France); Benateau, H.; Halley, A.; Compere, J.F. [Centre Hospitalier Universitaire, Service de Chirurgie Maxillo-Faciale et Stomatologie, 14 - Caen (France); Babin, E.; Bequignon, A. [Centre Hospitalier Universitaire, Service de d' Oto-Rhino-Laryngologie et Chirurgie Cervico-Faciale, 14 - Caen (France); Comoz, F. [Centre Hospitalier Universitaire, Service d' Anatomo-Pathologie, 14 - Caen (France)

    2004-03-01

    The sentinel lymph node (SLN) is the first lymph node draining the tumour. Aim of the study: To determine the negative predictive value of the SLN in the NO or NI squamous cell carcinomas (SCC) of the oral cavity or the oropharynx. Materials and method: SLN localization firstly requires a lymphoscintigraphy which is realised after four injections of radiolabelled colloids around the tumour. This scintigraphy allows a cutaneous marking of the SLN. Per operative detection of the SLN is performed with a detection probe. Results: One or more SLN have been localized in 20 of the 21 patients. No SLN was found in one patient whose tumour was a recurrence. (T2 NO MO) of a SCC of the oropharynx irradiated 3 years before. The failure rate of the method is 4,8% (1 false negative in 21 patients) and the false negative rate is 12,5% (1 false negative in 8 positive patients). This false negative patient had a T3 NO MO SCC of the oropharynx with a SLN found in level III, deep lateral cervical group. The neck dissection revealed one positive node in level lb, submandibular group, and 27 other nodes, all negative. The probability for the whole neck dissection to be negative when the SLN is negative (negative predictive value), is 92,3% (12/13) in our study. Conclusion: Our patient population is too small to obtain statistically significant conclusions. A maximum of 2 % of false negative patients is necessary to apply this method and avoid complete neck dissection in NO and NI tumours of the the oral cavity and the oropharynx with a negative SLN. (author)

  13. Radio-induced glioblastoma and myxoma after treatment of undifferentiated carcinoma of the nasopharynx; Glioblastome et myxome radio-induits apres traitement d'un carcinome indiffencie du nasopharynx

    Daoud, J.; Ben Salah, H. [Centre Hospitalier Universitaire Habib-Bourguiba, Service de Carcinologie-Radiotherapie, Sfax (Tunisia); Kammoun, W.; Ghorbel, A.; Drira, M.M. [Centre Hospitalier Universitaire Habib-Bourguiba, Service ORL, Sfax (Tunisia); Frikha, M. [Centre Hospitalier Universitaire Habib-Bourguiba, Service de Carcinologie Medicale, Sfax (Tunisia); Jlidi, R. [Centre Hospitalier Universitaire Habib-Bourguiba, Lab. d' Anatomo-Pathologie, Sfax (Tunisia); Besbes, M.; Maalej, M. [Institut Salah-Azaiz, Service de Carcinologie-Radiotherapie, Tunis (Tunisia)

    2000-12-01

    Radio-induced tumor have been known for a long time to occur after treatment of cancer during childhood. This entity is exceptional following radiotherapy of the cavum. Skull and facial osteosarcoma were described after treatment of UCNT. We report two observations of radio-induced tumors arising respectively three and seven years after treatment of UCNT. The first one is a temporo-parietal glioblastoma and the second is a rhino- and pharyngeal myxoma. The two patients are alive after treatment of the second tumor. The delay of appearance of these tumors, their situation in the field's irradiated and dose received suggests their radioinduced nature. However, the cytogenetic study is necessary to confirm the implication of radiotherapy in the genesis of these cancers. (authors)

  14. Prospective study of accelerated postoperative radiation therapy in patients with squamous-cell carcinoma of the head and neck; Radiotherapie externe acceleree postoperatoire des carcinomes epidermoides localement evolues de la sphere ORL: etude prospective de phase 2

    Zouhair, A.; Coucke, P.A.; Azria, D.; Moeckli, R.; Mirimanoff, R.O.; Ozsahin, M. [Centre Hospitalier Universitaire Vaudois CHUV, Service de Radio-Oncologie, Lausanne (Switzerland); Azria, D. [Centre Regional de Lutte Contre le Cancer Val-d' Aurelle-Paul-Lamarque, Dept. d' Oncologie- Radiotherapie, 34 - Montpellier (France); Pache, P. [Centre Hospitalier Universitaire Vaudois CHUV, Service d' ORL, Lausanne (Switzerland); Stupp, R. [Centre hospitalier Universitaire Vaudois CHUV, Centre Pluridisciplinaire d' Oncologie Medicale, Lausanne (Switzerland)

    2003-08-01

    Purpose. - To assess the feasibility and efficacy of accelerated postoperative radiation therapy (RT) in patients with squamous-cell carcinoma of the head and neck (SCCHN). Patients and methods. - Between December 1997 and July 2001, 68 patients (male to female ratio: 52/16; median age: 60-years (range: 43-81)) with pT1-pT4 and/or pN0-pN3 SCCHN (24 oropharynx, 19 oral cavity, 13 hypopharynx, 5 larynx, 3 unknown primary, 2 maxillary sinus, and 2 salivary gland) were included in this prospective study. Postoperative RT was indicated because extra-capsular infiltration (ECT) was observed in 20 (29%), positive surgical margins (PSM) in 20 (29%) or both in 23 patients (34%). Treatment consisted of external beam R 66 Gy in 5 weeks and 3 days. Median follow-up was 15 months. Results. -According to CTC 2.0, acute morbidity was acceptable: grade 3 mucositis was observed in 15 (22%) patients, grade 3 dysphagia in 19 (28%) patients, grade 3 skin erythema in 21 (31%) patients with a median weight loss of 3.1 kg (range: 0-16). No grade 4 toxicity wa observed. Median time to relapse was 13 months; we observed only three (4%) local and four (6%) regional relapses, whereas eight (12%) patients developed distant metastases without any evidence of locoregional recurrence. The 2 years overall-, disease-free survival, an actuarial locoregional control rates were 85, 73 and 83% respectively. Conclusion.- The reduction of the overall treatment time using postoperative accelerated RT with weekly concomitant boost (six fraction per week) is feasible with local control rates comparable to that of published data. Acute RT related morbidity is acceptable. (author)

  15. Effets des nanoparticules de siRNA-Squalne sur les oncognes de jonction RET/PTCs dans le carcinome papillaire de la thyrode : tudes molculaires, cellulaires et investigations prcliniques

    Ali, Hafiz Muhammad

    2014-01-01

    Le cancer papillaire de la thyrode (PTC) est celui le plus frquent de la thyrode. Il est caractris par des rarrangements chromosomique affectant le gne RET, dont les plus frquemment observs sont RET/PTC1 et RET/PTC3. Les oncogne de jonction sont spcifiques la tumeur et reprsentent une cible privilgie pour une thrapie cible par des petits ARN interfrents (siRNA). Notre but est dintroduire une nouvelle approche pharmacologique par siRNA pour les PTC. Pour raliser nos expri...

  16. Preoperative scintigraphic detection of lung metastases of a follicular thyroid carcinoma associated with hyperthyroidism; Detection scintigraphique preoperatoire de metastases pulmonaires d'un carcinome vesiculaire de la thyroide associe a une hyperthyroidie

    Biyi, A.; Oufroukhi, Y.; Doudouh, A. [Hopital Militaire d' Instruction Mohammed V, Rabat Instituts, Service de Medecine Nucleaire, Rabat (Morocco); Baizri, H.; El Quatni, M. [Hopital Militaire d' Instruction Mohammed V, Service d' Endocrinologie, Rabat (Morocco); Al Bouzidi, A. [Hopital Militaire d' Instruction Mohammed V, Service d' Anatomie Pathologique, Rabat (Morocco)

    2009-10-15

    Preoperative accumulation of radioiodine in metastases of thyroid carcinoma and its association with hyperthyroidism are uncommon. We report a case of 58-year-old woman with follicular thyroid carcinoma revealed by thyrotoxicosis caused by a hot nodule, and bilateral pulmonary uptake of I-131 before total thyroidectomy. Despite four ablative doses of I-131, bone metastases were identified and the patient died 42 month after the initial diagnosis. (authors)

  17. Epidermoid carcinomas of the anal canal treated with definitive radiation therapy in a series of 305 patients; Carcinomes epidermoides du canal anal traites par irradiation a visee curative: a propos de 305 patients

    Deniaud-Alexandre, E.; Touboul, E.; Huang, R.; Qu, S.H.; Pene, F.; Schlienger, M. [Hopital Tenon, Service d' Oncologie-Radiotherapie, 75 - Paris (France); Tiret, E.; Parc, R. [Hopital Saint-Antoine, Service de Chirurgie Digestive, 75 - Paris (France); Sezeur, A. [Hopital des Diaconesses, Service de Chirurgie Generale, 75 - Paris (France); Houry, S. [Hopital Tenon AP-HP, Service de Chirurgie Digestive, 75 - Paris (France); Gallot, D. [Groupe Hospitalier Bichat-Claude-Bernard, Service de Chirurgie Generale et Digestive B, 75 - Paris (France)

    2003-08-01

    Purpose. - To identify prognostic factors and treatment toxicity in a series of epidermoid cancers of the anal canal without evident metastasis. Patients and methods. - Between June 1972 and January 1997, 305 patients (pts) were treated with curative-intent radiation therapy (RT). The T-stages according to the 1987 UICC classification were: 26 T1, 141 T2, 104 T3, and 34 T4. There were 49 pts with nodal involvement at presentation. Pretreatment anal function scoring according to our in-house system was: 22 scored 0, 182 scored 1, 74 scored 2, 7 scored 3. 11 scored 4, and 9 not available pts. The treatment started with external beam RT (EBRT) in 303 pts (median dose: 45 Gy). After a rest period of 4 to 6 weeks, a boost of 20 Gy was delivered by EBRT in 279 pts and by interstitial {sup 192}Ir brachytherapy (Bcy) in 17 pts. Seven pts received only one course of EBRT (mean dose: 49.5 Gy) and 2 pts were treated with interstitial {sup 192}Ir Bcy alone (55 and 60 Gy, respectively). concomitant chemotherapy (5-fluoro-uracil and either mitomycin C or cisplatin) was delivered to 19 pts. Mean follow-up was 103 months. Results. - At the end of RT local tumor clinical complete response (cCR) rate was 80%. Out of 61 non responders or local progressive tumors 27 (44%) were salvaged with abdomino-perineal resection (APR). The rate of local tumor relapse (LR) was 12%. Out of 37 LTR, 20 (54%) were salvaged with APR and one with interstitial {sup 192}Ir Bcy. The overall local tumor control (LC) rate with or without salvage local treatment was 84%. LC rate with a good anal function scoring (score 0 and 1) was 56.5%0. Among 181/186 available pts who preserved their anus, 94% had a good anal function scoring. For a subgroup of 15 pts with length tumor <2 cm-N0, the LC rate after the end of RT was 100% the LC rate with or without local salvage treatment was 100%, and among 13 available pts who preserved their anus, the anal function scoring was good in 12 pts (92%). The 10-years disease-free survival was 74%. After multivariate analysis, 3 independent predicting factors significantly influenced the disease-free survival: gap duration between 2 courses of RT (>38 days vs {<=}38 days, P=0.0025), pretreatment anal function scoring (0 vs 1 vs 2 vs 3 vs 4, P =4.4 10{sup -6}), and cCR after the end of RT (no complete response vs complete response, P =2.5 10{sup -14}). Conclusion. - We confirm excellent results with RT in T1 and T2 lesions. However, chemoradiotherapy should be preferred to improves survival free. of colostomy with a good anal sphincter function for tumors more than or equal to 2 cm in length and locally advanced tumors. (author)

  18. Long-term results and prognostic factors of squamous cell carcinoma of the anal canal treated by irradiation; Resultats a long terme et facteurs pronostiques des carcinomes epidermoides du canal anal traites par irradiation

    Tournier-Rangeard, L.; Peiffert, D.; Lafond, C.; Mege, A. [Centre Alexis-Vautrin, Dept. de Radiotherapie et Curietherapie, 54 - Vandoeuvre-les-Nancy (France); Metayer, Y.; Marchesi, V.; Buchheit, I. [Centre Alexis-Vautrin, Dept. de Radiophysique, 54 - Vandoeuvre-les-Nancy (France); Uwer, L.; Conroy, T.; Kaminsky, M.C. [Centre Alexis-Vautrin, Dept. d' Oncologie Medicale, 54 - Vandoeuvre-les-Nancy (France)

    2007-06-15

    Purpose To analyze the prognostic factors of loco regional control (L.R.C.), specific survival (S.S.) and sphincter conservation (S.C.) of patients treated by curative and conservative irradiation for an epidermoid cancer of anal canal in our institution. Patients and methods From 1976 to 2005, 286 patients (pts) were treated by exclusive radiotherapy (180 pts) or chemo-radiotherapy (106 pts) followed by a brachytherapy boost (233 pts) or external beam radiotherapy boost (24 pts). Forty-three pts were stage I, 154 stage II, 31 stage IIIA and 53 stage IIIB. Results The mean follow-up was 65 months (range: 1.3-250 months). The 5-years-overall survival and S.S. rates were 66.4% and 78.1% respectively. In multivariate analysis, tumor size (? 40 mm) [R.R. = 2.1], node involvement (R.R. = 2.4), and poor response (< 75%) to first course irradiation [R.R. = 1.9], local relapse (R.R. = 4.5) and distant metastases were factors of poor prognosis for S.S.. Five-years-L.R.C. were 71.5% (88% for stage I, 69% for stage II, 77%, for stage IIIA and 60% for stage IIIB). Prognosis factors of L.C.R. were tumor size (R.R. = 2.5), response to first course of irradiation (R.R. = 2.9). S.C. was 71% at 5 years. Prognosis factors of S.C. were tumor size (R.R. = 1.9) and response to first course of irradiation (R.R. = 2.4). Conclusion The results of this series are similar to those of the literature. As well as initial tumor extension, response to first course of irradiation was found as prognostic factor on L..R., S.S., S.C.. Our results are similar to other series and brachytherapy seems not to be deleterious. Its impact to local control remains to be evaluated. (authors)

  19. {sup 99m}Tc-HMDP uptake mechanism in calcified transitional cell carcinoma; Mecanisme de fixation du {sup 99m}Tc-HMDP sur les carcinomes urotheliaux calcifies de vessie

    Biyi, A.; Doudouh, A.; Oufroukhi, Y. [Hopital Militaire d' Instruction Mohammed-V, Service de Medecine Nucleaire, Rabat (Morocco); El Abbar, M. [Hopital Militaire d' Instruction Mohammed-V, Service d' Urologie, Rabat (Morocco); Al Bouzidi, A. [Hopital Militaire d' Instruction Mohammed-V, Service d' Anatomie Pathologique, Rabat (Morocco)

    2009-02-15

    We report a case of transitional cell carcinoma of the bladder visualized on a {sup 99m}Tc-HMDP bone scintigraphy. CT demonstrated irregular tumor of the bladder with curvilinear calcifications on the surface areas and multiple bilateral pulmonary metastases. Bone scintigraphy showed intense uptake corresponding to the bladder tumor and two bone metastases on the left femur. A few days later, the patient underwent retrograde injection of {sup 99m}Tc-HMDP into the bladder. Imaging made after voiding showed a tumour uptake of the skeletal labelled agent. Through this case report, we debate {sup 99m}Tc-bi-phosphonate uptake mechanisms in transitional cell carcinoma. (authors)

  20. Apport de la pathologie intégrative dans l'identification de biomarqueurs dans les carcinomes pulmonaires non à petites cellules : pathologie intégrative et cancer du poumon

    Ilie, Marius Ionut

    2013-01-01

    Le cancer pulmonaire non à petites cellules (CNPC) est la première cause de décès par cancer dans le monde. Ce cancer est souvent découvert tardivement, il est agressif, et il est chimio-résistant. La découverte de biomarqueurs pourraient représenter une percée majeure pour la prise en charge de ces patients, en facilitant le diagnostic, le pronostic et orienter vers le choix du traitement le plus approprié. Nous avons exploré plusieurs aspects liés à la progression tumorale dans le but d’ide...

  1. Re-irradiation in stereotactic conditions and cetuximab for local relapses of epidermoid carcinoma of head and neck; Reirradiation en conditions stereotaxiques et cetuximab pour des recidives locales de carcinome epidermoide de la tete et du cou

    Vasseur, F.; Comet, B.; Faivre-Pierret, M.; Coche-Dequeant, B.; Degardin, M.; Lefebvre, J.L.; Lacornerie, T.; Lartigau, E. [Departement universitaire de radiotherapie, centre Oscar Lambret, 59 - Lille (France); Universite Lille-2, 59 (France)

    2010-10-15

    The authors report a work aimed at assessing the feasibility and toxicity of a re-irradiation treatment in stereotactic conditions using CyberKnife and cetuximab in the case of local relapses of epidermoid cancers of the ORL sphere. Thirty three patients have been submitted to this treatment between June 2007 and April 2009. Although six patients died by six months, this treatment seems to be a good alternative, and presents an acceptable short-term toxicity. Further studies are needed to compare this technique to other therapeutic techniques, and to assess the risk of long term complications. Short communication

  2. Intensity-Modulated or Proton Radiation Therapy for Sinonasal Malignancy

    2016-02-10

    Adenoid Cystic Carcinoma; Squamous Cell Carcinoma; Sinonasal Carcinoma; Sinonasal Undifferentiated Carcinoma; Mucoepidermoid Carcinoma; Schneiderian Carcinoma; Myoepithelial Carcinoma; Esthesioneuroblastoma; Melanoma

  3. Orthodontic treatment after adenoidectomy patients: effect on jaw relations in saggital plane

    Gupta, Nitin; Gupta, Seema Diwan; Varshney, Saurabh; Singh, Rakesh; Bist, S. S.; Barthwala, Jhooma

    2009-01-01

    Adenoid hypertrophy is a normal phenomenon seen in young children. Adenoids may however be of large size or may not reduce in size in adulthood. Large adenoids may cause mouth breathing, overcrowding of teeth or otological symptoms. When adenoids are large and producing these effects, adenoidectomy is necessary. Adenoidectomy immensely benefits such patients but they may still continue to be habitual mouth breathers. This can lead to formation of long narrow face, labially protruded maxillary...

  4. Gene expression profiles of papillary and annaplastic thyroid carcinomas

    Delys, Laurent

    2007-01-01

    Les tumeurs thyroïdiennes constituent les tumeurs endocrines les plus fréquentes. Parmi celles-ci, on distingue les adénomes, tumeurs bénignes et encapsulées, et les carcinomes, tumeurs malignes. Ceux-ci sont eux-mêmes subdivisés, principalement sur base histologique, en carcinomes papillaires ou folliculaires, qui conservent certaines caractéristiques de différenciation des cellules thyroïdiennes initiales dont ils dérivent, et qui peuvent évoluer en carcinomes anaplasiques, totalement dédif...

  5. [Variations in the biological behavior of neoplasms of the oral mucosa].

    Müller, A; Braun, L

    1976-01-01

    Up to now the biological potencies of a carcinom of the oral mucous membrane cannot be determined metrically in individual cases. Based upon investigations of the frequency of metastase formation of oral carcinoms within regional lymphatic nodes one cannot draw reliable conclusions as to the dependence of regional metastase formation upon the T-stage. Therefore surgical treatment of regional lymphatic nodes is considered necessary also in early stages. PMID:137627

  6. Torsion d'annexe aprs hystrectomie abdominale: une premire observation

    Elhjouji, Abderrahman; Zahdi, Othman; Baba, Hicham; Belhamidi, Said; Bounaim, Ahmed; Aitali, Abdelmounaim; Sair, Khalid

    2015-01-01

    La torsion d'annexes survient classiquement sur ovaires kystiques ou tumoraux. De rares cas de torsion ont t rapports dans la littrature aprs hystrectomie laparoscopique. Nous rapportons la premire observation de torsion d'annexe survenant sur annexe normale aprs hystrectomie abdominale et dcrivons les particularits de cette forme clinique. PMID:26759694

  7. HYPERTROPHICALUM ADENOIDIS IN RE-LATIUM CUM SECRETUM OTTITIS IN MEDIAM

    Lidija DUBROVSKA-MILETIC; Marina DAVCEVA-CAKAR

    1999-01-01

    In this study we presented the treatment of 20 children with secretory otitis media (SOM). The treatment was surgical and it considened-ventilaton tube insertion and adenoidectomy in case of enlarged adenoid. In this clinical investigation was enroll 15 boys and 5 girls in age 5 to 10 were divided in two main groups:1. 9 children without enlarged adenoid2. 11 children with confirmed enlarged adenoidClinical material was analyzed according to hearing level, middle ear condition estimated by pu...

  8. Carcinoma adenoescamoso do colo uterino mimetizando carcinoma adenóide basal: relato de um caso e revisão da literatura Adenosquamous carcinoma of the cervix mimicking adenoid basal carcinoma: case report and review of the literature

    Álvaro Piazzeta Pinto; Luiz Roberto Maia

    2007-01-01

    O carcinoma adenoescamoso do colo uterino é definido como um tumor que contém uma mistura de células malignas com diferenciação escamosa e glandular. A literatura salienta a importância de se fazer esse diagnóstico, uma vez que, quando os componentes não são bem diferenciados ou não se encontram evidentes na amostra analisada, esse tumor pode ser erroneamente interpretado como carcinoma escamoso ou adenocarcinoma. O presente trabalho descreve a apresentação pouco comum de um carcinoma adenoes...

  9. Thyroid cancer arising after iodine 131 treatment of thyreotoxicosis

    A case report is presented of thyroid carcinom developing after 131I treatment for thyreotoxicosis. The patient, a female, had received a total 131I activity of 31 mCi administered in 12 fractions, namely, 2 x 1.5 mCi, 1 x 2 mCi, 2 x 2.5 mCi and 7 x 3 mCi. Therteen years later she developed thyroid cancer with metastatic disseminations in cervical and mediastinal nodes. The carcinom was of undifferentiated type, displaying abortive follicles in some areas. In spite of separate reports on appearance of thyroid carcinoms following radioactive iodine therapy and the existence of consistent experimental data on 131I carcinogenicity, the authors adhere to the view that there is no relationship between therapeutic administration of radioactive iodine and development of thyroid tumors. (A.B.)

  10. Cancer mtaplasique du sein: propos d'un cas

    Babahabib, Moulay Abdellah; Chennana, Adil; Hachi, Aymen; Kouach, Jaoud; Moussaoui, Driss; Dhayni, Mohammed

    2014-01-01

    Les carcinomes mtaplasiques du sein sont des tumeurs rares. Ils constituent un groupe htrogne de tumeurs dfinis selon l'organisation mondiale de la sant comme tant un carcinome canalaire infiltrant mais comportant des zones de remaniements mtaplasiques (de type pidermode, cellules fusiformes, chondrode et osseux ou mixte), qui varient de quelques foyers microscopiques un remplacement glandulaire complet. Les aspects cliniques et radiologiques ne sont pas spcifiques. Le traitement associe la chirurgie, la radiothrapie et la chimiothrapie. L'hormonothrapie n'a pas de place. Le pronostic est sombre. L'histopathologie combine l'immunohistochimie permet de poser un diagnostic sure. Etant donn que la prise en charge thrapeutique est limite, une nouvelle approche molculaire pourrait modifier cette contribution faible et mal cerne des traitements systmiques classiques. Les patientes atteintes de carcinome mtaplasique mammaire pourraient bnficier de traitements cibls, ce qui reste confirmer par des essais cliniques. PMID:25870723

  11. Late complications and sequelae of radiotherapy of adult's nasopharyngeal carcinomas. A study of 79 patients in Gustave-Roussy Institute. Complications tardives et sequelles de la radiotherapie des carcinomes du nasopharynx chez l'adulte. A propos de 79 patients traites a l'institut Gustave-Roussy entre 1970 et 1978

    Bensadoun, R.J. (Centre Antoine-Lacassagne, 06 - Nice (FR)); Eschwege, F.; Schwaab, G.; Wibault, P. (Centre de Lutte contre le Cancer Gustave Roussy, 94 - Villejuif (FR))

    1991-01-01

    179 patients with nasopharyngeal carcinoma, all older than 16 years, were treated by radiotherapy at the Gustave-Roussy Institute. Seventy-nine of these patients, in complete remission two months after irradiation at curative doses, were followed up for at least one year after completion of therapy. All sequelae and complications attributable to treatment which occurred from one to 16 years after irradiation were recorded with the aid of grading systems, and the circumstances of their occurrence and their evolution were compared to similar information in the literature. Analysis of this follow-up data revealed a non-negligible frequency of crippling late complications comparable to the rates reported in major studies on exclusive radiotherapy of nasopharyngeal carcinomas. In terms of quality of survival for example, this study revealed that the percentage of disease-free patients who present a highly disturbed life rose significantly between 4 and 10 years of follow-up: 1.9% 4 years after irradiation, 19% at ten years (P U 0.01). However, more than 3/4 disease-free patients lead a normal or hardly disturbed life at 10 years. The accumulation of complications in certain patients has to be emphasized: at 7 years, 30% of the patients accounted for 70% of recorded complications. Therefore, this study under scores the need for optimization of therapeutic protocols (through technical and ballistic improvement of irradiation, and association with chemotherapy for example) to prevent as much as possible late radiation-induced disease.

  12. First chemotherapy by docetaxel, cisplatin and 5-fluoro-uracil (T.P.F.) followed by concomitant chemoradiotherapy in the treatment of cavum locally evolved undifferentiated carcinomas without metastases; Chimiotherapie premiere par docetaxel, cisplatine et 5-fluoro-uracile (TPF) suivie de chimioradiotherapie concomitante dans le traitement des carcinomes indifferencies localement evolues non metastatiques du cavum

    Sahli, B.; Bali, M.S.; Miles, I.; Djemaa, A. [CHU Benbadis, Constantine (Algeria)

    2009-10-15

    It is a prospective study in order to evaluate the feasibility and the toxicity of a chemotherapy by docetaxel, cisplatin and 5-fluoro-uracil followed by a concomitant chemoradiotherapy in the treatment of non metastatic locally evolved undifferentiated carcinomas of the cavum. The conclusion was despite the low number of patients in our series, the observed results show that this neoadjuvant chemotherapy followed by a concomitant chemoradiotherapy in the locally evolved undifferentiated carcinomas of the cavum is feasible. however, the high acute toxicity needs the use of conformal irradiation techniques. Besides, a longer follow up is necessary to evaluate the therapy efficiency and the delayed toxicity of this protocol. (N.C.)

  13. Does {sup 18}FDG PET-CT improve the detection of posttreatment recurrence of head and neck squamous cell carcinoma in patients negative for disease on clinical follow-up?; Interet de la tomographie par emission de positons (TEP) au {sup 18}FDG dans le suivi des patients traites pour carcinome epidermoide des voies aerodigestives superieures (VADS) en remission clinique

    Abgral, R.; Querellou, S.; Le Roux, P.Y.; Le Duc-Pennec, A.; Bizais, Y.; Salaun, P.Y. [CHU de Morvan, Service de Medecine Nucleaire, 29 - Brest (France); Potard, G.; Marianowski, R. [CHU de Morvan Cavale-Blanche, Service d' ORL, 29 - Brest (France); Pradier, O. [CHU de Morvan, Service d' Oncologie-Radiotherapie, 29 - Brest (France); Kraeber-Bodere, F. [CHU Hotel-Dieu, Service de Medicine Nucleaire, 44- Nantes (France)

    2009-02-15

    Introduction: post-treatment follow-up of head and neck squamous cell carcinoma (H.N.S.C.C.) recurrence is a diagnostic challenge. Tissue distortions from radiation and surgery can obscure early detection of recurrence by conventional follow-up approaches such as physical examination (P.E.), computed tomography, and magnetic resonance imaging. A number of studies have shown that {sup 18}Fluoro-fluorodeoxyglucose ({sup 18}F.D.G.) Positron emission tomography (PET) may be an effective technique for the detection of persistent, recurrent, and distant metastatic HNSCC after treatment. The aim of this prospective study was to determine the benefits (sensitivity, specificity, predictive values, and accuracy) of {sup 18}F.D.G. PET using hybrid PET 'Computed tomography system (PET/CT) in the detection of HNSCC subclinical locoregional recurrence and distant metastases, in patients 12 months after curative treatment with a negative conventional follow up. Materials and Method Ninety-one patients cured from head and neck squamous cell carcinoma (HNSCC) without any clinical element for recurrence were included. Whole-body {sup 18}F.D.G. PET/CT examination was performed 11.6 {+-} 4.4 months after the end of the treatment. The gold standard was histopathology or 6 months imaging follow-up. Result The whole-body {sup 18}F.D.G. PET/CT of the 91 patients in this study consisted of 52 negative and 39 positive results. Nine of these patients who exhibited abnormal {sup 18}F.D.G. uptake in head and neck area did not have subsequently proven recurrent HNSCC (false positive). Thirty had proven recurrence (true positive). All 52 patients with negative readings of {sup 18}F.D.G. PET/CT remained free of disease at 6 months (true negative). The sensitivity and specificity of {sup 18}F.D.G. PET/CT in this study for the diagnosis of HNSCC recurrence were 100% (30/30) and 85% (52/61) respectively. The positive predictive value was 77% (30/39). The negative predictive value was 100% (52/52). The overall accuracy was 90% (82/91). Conclusion: the results of our study confirm the high effectiveness of {sup 18}F.D.G. PET/CT in assessment of HNSCC recurrence. It suggests that this modality is more accurate than conventional follow-up PE alone in the assessment of patient recurrence after previous curative treatment for HNSCC. Therefore, a PET study could be systematically proposed at 12 months after the end of the treatment. (authors)

  14. Impact of additional cervical dedicated {sup 18}FDG-PET-CT on the management of head and neck squamous cell carcinoma; Impact therapeutique de l'acquisition cervicale dediee en [{sup 18}F]-FDG-TEP-TDM sur la prise en charge des carcinomes epidermoides de la tete et du cou

    Queneau, M.; Tourdias, T.; Guyot, M.; Allard, M.; Fernandez, P. [CHU Pellegrin-Tripode, Service de Medecine Nucleaire, 33 - Bordeaux (France); Houliat, H. [CHU Pellegrin-Tripode, Service d' Oto-Rhino-Laryngologie et de Chirurgie Cervico-Faciale du Pr Bebear, 33 - Bordeaux (France)

    2008-09-15

    Aim of the study: To investigate the therapeutic impact of additional cervical dedicated {sup 18}F.D.G.-PET-CT on the management of head and neck squamous cell carcinoma (H.N.S.C.C.). Materials and methods: Thirty patients with H.N.S.C.C. underwent a [{sup 18}F]-F.D.G.-PET-CT standard, whole-body scan completed by a cervical dedicated protocol. Two physicians blindly reviewed the exams and the results were discussed with surgeons to determine the therapeutic impact of the dedicated protocol. Result: Among 30 patients, only four (13%) discordant results were registered by the both observers, and two more by only one observer (k = 0.75, S.D. = 0.08). As to the four patients: 1) a N0 staged patient on whole body (W.B.) exam was upstaged to N2b in cervical PET (obese patient, whole-body exam with poor quality), 2) for a second patient, no node was described on whole-body scan, but one lymph node in each cervical chain was observed in focused PET, with low standardized uptake value (S.U.V. value), 3) in the other two cases, cervical PET scan upstaged from N2a to N2b and from N2a to N2c (S.U.V. < 3), without any influence on treatment management. Conclusion: Our results show that additional cervical dedicated PET-CT does not modify the management of patients with H.N.S.C.C. when compared to whole-body PET-CT, except for particular obese or N0 patients, allowing to reduce patient CT radiation dose and time-consuming PET acquisition. (authors)

  15. Metastatic calcifications of hyperparathyroidism detected by M.D.P.- Tc 99 m bone scintigraphy in patients with parathyroid carcinoma: A case report; Les calcifications metastatiques de l'hyperparathyroidie identifiees par scintigraphie osseuse au M.D.P.-Tc 99 m dans le cadre du carcinome parathyroidien: a propos d'un cas

    Doudouh, A.; Biyi, A.; Oufroukhi, Y.; Zekri, A. [Hopital Militaire Mohammed-5, Service de Medecine Nucleaire, Rabat (Morocco); Sekkach, Y. [Hopital Militaire Mohammed-5, Service de Medecine B, Rabat (Morocco)

    2008-02-15

    The authors report a case of gastric, renal, pulmonary, and myocardial uptake of M.D.P.-Tc 99 m in a patient with parathyroid carcinoma. Parathyroid carcinoma is a rare cause of primary hyperparathyroidism which becomes complicated during its evolution by metastatic calcifications. Metastatic calcifications are frequently located in lungs and heart. If an adequate treatment is not undertaken, these calcifications progress and evolve into severe respiratory and cardiac complications. In our patient, quasi-complete disappearance of metastatic calcifications on the follow-up bone scintigraphy, performed four weeks after surgical cure of parathyroid tumour, indicates the great interest of this examination in early identification of metastatic calcifications and monitoring of their disappearance after treatment. (authors)

  16. Fluoro choline({sup 18}F) has a clinical usefulness in prostate cancer and in hepatocellular carcinoma sometimes in the same patient;La fluorocholine({sup 18}F) a une utilite clinique dans le cancer de la prostate et le carcinome hepatocellulaire parfois chez le meme malade

    Balogova, S.; Kerrou, K.; Huchet, V.; Gutman, F.; Montravers, F.; Talbot, J.N. [Universite Pierre-et-Marie-Curie, Service de medecine nucleaire, hopital Tenon, AP-HP, 75 - Paris (France); Balogova, S. [Universite Comenius, Bratislava (Slovakia); Bumsel, F. [Universite Pierre-et-Marie-Curie, Service d' hepato-gastro-enterologie, hopital Saint-Antoine, AP-HP, 75 - Paris (France); Nataf, V. [Hopital Tenon, AP-HP, Radiopharmacie, 75 - Paris (France); Mal, F. [Institut mutualiste Montsouris, Departement de pathologie digestive, 75 - Paris (France)

    2010-07-15

    Case report: In order to stage hepatocellular carcinoma (H.C.C.), a patient was referred to PET/CT using fluorodeoxyglucose({sup 18}F) (F.D.G.) and, if necessary, fluoro choline({sup 18}F) (F.C.H.). H.C.C. was proven by biopsy of a hepatic mass discovered on CT performed for a biological recurrence of prostate cancer. Result: F.D.G. PET/CT did not show any anomaly. F.C.H. PET/CT was thus performed and showed various foci: the hepatic mass, a large abdominal adenopathy and an unexpected sub centimeter lung nodule. The diagnostic uncertainty mostly concerned this lung nodule which was biopsied and consisted of a metastasis of the prostate cancer. Due to the presence of two metastatic cancers, the patient's management was altered, with chemotherapy for the H.C.C. and hormone therapy for the prostate cancer. Conclusion: Several types of cancer take-up fluoro choline({sup 18}F), which is a powerful tool to detect metastases, in particular in case of rising levels of marker with a negative F.D.G. PET/CT. Even when F.D.G. PET/CT is positive, F.C.H. may reveal unexpected foci with other metabolic characteristics, although it is not specific of a given primary cancer, as well as F.D.G.. For staging of H.C.C., we thus recommend to perform PET/CT with both tracers. (authors)

  17. Radiothérapie externe accélérée postopératoire des carcinomes épidermoïdes localement évolués de la sphère ORL : étude prospective de phase II

    Zouhair, A; COUCKE, Philippe; Azria, D; Pache, P.; Stupp, R.; Moeckli, R.; Mirimanoff, R O; Ozsahin, M

    2003-01-01

    Abstract Purpose. – To assess the feasibility and efficacy of accelerated postoperative radiation therapy (RT) in patients with squamous-cell carcinoma of the head and neck (SCCHN). Patients and methods. – Between December 1997 and July 2001, 68 patients (male to female ratio: 52/16; median age: 60-years (range: 43–81) with pT1-pT4 and/or pN0-pN3 SCCHN (24 oropharynx, 19 oral cavity, 13 hypopharynx, 5 larynx, 3 unknown primary, 2 maxillary sinus, and 2 salivary gland) were incl...

  18. Diagnostic performances of the S.R.S. (scintigraphy of somatostatin receptors) and of the PET-F.D.G. in the extension situation of the well differentiated endocrine carcinomas at high Ki67; Performances diagnostiques de la SRS et de la TEP-FDG dans le bilan d'extension des carcinomes endocrines bien differencies a Ki67 eleve ({>=} 10%)

    Abgrala, R.; Leboulleux, S.; Deandreis, D.; Lumbroso, J.; Schlumberger, M.; Baudin, E. [Medecine nucleaire, institut Gustave-Roussy, Villejuif, (France); Auperin, A. [Biostatistiques, Institut Gustave-Roussy, Villejuif, (France); Dromain, C. [radiologie, institut Gustave-Roussy, Villejuif, (France); Guigay, J. [pneumologie, institut Gustave-Roussy, Villejuif, (France); Ducreux, M. [hepato-gastroenterologie, Institut Gustave-Roussy, Villejuif, (France)

    2009-05-15

    The results suggest that among 90% of patients with well differentiated endocrine carcinomas at high Ki, the PET-F.D.G. is more noticeable or equivalent to the scintigraphy of somatostatin receptors (S.R.S.). (N.C.)

  19. Whole brain radiation with supplementary boost for patients for unique brain metastasis from a primitive lung cancer; Experience de l'irradiation encephalique totale avec escalade de dose focalisee pour le traitement des metastases cerebrales uniques d'un carcinome bronchopulmonaire

    Levy, A.; Lamproglou, I. [Service de radiotherapie, groupe hospitalier Pitie-Salpetriere, 47-83, boulevard de l' Hopital, 75013 Paris (France); Chargari, C. [Service de radiotherapie, groupe hospitalier Pitie-Salpetriere, 47-83, boulevard de l' Hopital, 75013 Paris (France); Service de radiotherapie, hopital d' instruction des armees Val-de-Grace, 75005 Paris (France); Mazeron, J.J. [Service de radiotherapie, groupe hospitalier Pitie-Salpetriere, 47-83, boulevard de l' Hopital, 75013 Paris (France); Universite Pierre-et-Marie-Curie Paris 6, 4, place Jussieu, 75005 Paris (France); Krzisch, C. [Service de radiotherapie, CHU d' Amiens-Picardie, place Victor-Pauchet, 80054 Amiens cedex (France); Assouline, A. [Service de radiotherapie, groupe hospitalier Pitie-Salpetriere, 47-83, boulevard de l' Hopital, 75013 Paris (France); Universite Pierre-et-Marie-Curie Paris 6, 4, place Jussieu, 75005 Paris (France); Service de radiotherapie, CHU d' Amiens-Picardie, place Victor-Pauchet, 80054 Amiens cedex (France)

    2011-08-15

    Purpose. - To assess the potential benefit of a boost in patients treated with whole brain irradiation by a conventional linear accelerator for lung cancer solitary brain metastasis. Patients and methods. - From 2002 to 2006, a retrospective analysis was carried out from 64 unselected consecutive patients with secondary brain metastasis from lung cancer, treated with whole brain irradiation without surgical resection. Thirty patients (47%) received a boost in their brain metastases. Three potential prognostic factors were studied: sex, RPA score and improvement of neurological symptoms after radiotherapy. An analysis was conducted to determine whether an additional dose may improve survival in the absence of surgical resection. Results. - The mean follow-up was 4.9 months. The median overall survival was 8.5 months (6.4 to 10.7 months). The total dose of radiotherapy was the only significant prognostic factor for overall survival. The median overall survival was 6.2 months for patients without additional radiation versus 11.2 months for patients receiving a boost dose (p = 0.011). Sex, RPA score and improvement of neurological symptoms after radiotherapy were not found as prognostic factors for overall survival. Conclusions. - Boost delivered after whole brain radiation therapy by a conventional particle accelerator may provide a benefit in selected patients, especially for centres that do not have radiotherapy techniques in stereotactic conditions. This warrants further prospective assessment. (authors)

  20. Should the pulmonary scintigraphy of pre-surgery examination of bronchial carcinomas be made at rest or under effort?; La scintigraphie pulmonaire du bilan pre-operatoire des carcinomes bronchiques doit elle etre realisee au repos ou a l`effort?

    David, N.; Olivier, P.; Arsena, T.; Quiri, N.; Hassan, N.; Haouzi, P.; Borelly, J.; Marie, P.Y.; Karcher, G.; Bertrand, A. [Service de Medecine Nucleaire, CHU - Nancy (France)

    1997-12-31

    One of the key elements in deciding whether a patient, bearing a bronchial carcinoma, should be subject to a surgery is the predicted value of the post-surgery maximal exhaled volume per second (MEVS), usually determined by means of an at-rest pulmonary perfusion scintigraphy. At the same time, this parameter remains rather badly correlated to mortality and peri-surgical morbidity. The goal of this study was to determine whether under-effort pulmonary perfusion scintigraphy, i.e. in peri-surgical conditions gives different results in this case. Twenty patients bearing bronchial carcinoma have benefited by a pulmonary scintigraphy, successively, in the end of an exercise on ergo-metric bicycle and at rest. Two mCi of Tc-labelled macro-aggregate albumin were injected after effort, then 10 mCi one hour later, at rest. The homo-lateral lung perfusion to tumor, expresses in % of total pulmonary perfusion (% TP), was reduced at rest (-8 {+-} 6%) and at effort (-10 {+-} 8%), in comparison with the normal values. On the analysis of ensemble of population (43 {+-} 7% vs 41 {+-} 9%, NS) the % TP did not changed significantly between the at-rest and under-effort acquisitions. At the same time, 4 patients presented important variation, amounting up to 20% of total pulmonary perfusion: the % TP increased in 2 cases and decreased in the other 2 cases. In conclusion, in the patients bearing bronchial carcinoma, the relative perfusion of tumoral lung varies under effort in a non-negligible number of cases (4/20). Additional studies are necessary to establish the value of under-effort pulmonary scintigraphy, in the evaluation of the post-surgery respiratory functional capacity

  1. Thyroid medullary carcinoma and PET/CT with {sup 18}F-DOPA in the post surgery follow up: preliminary results; Carcinome medullaire de la thyroide et TEP/TDM a la {sup 18}F-DOPA dans le suivi post-chirurgical: resultats preliminaires

    Keomany, J.; Rust, E.; Constantinesco, A.; Imperiale, A. [CHU de Strasbourg, Service de biophysique et medecine nucleaire, 67 (France); Detour, J. [CHU de Strasbourg, Service de radiopharmacie, 67 (France); Chabrier, G.; Goichot, B. [CHU de Strasbourg, Service de medecine interne, endocrinologie et nutrition, 67 (France); Schneegans, O. [FNCLCC Paul-Strauss, 67 - Strasbourg (France)

    2010-07-01

    Purpose: to study the contribution of the PET/CT with {sup 18}F DOPA in the therapy follow-up of patients with a history of medullary thyroid carcinoma and biological suspicion of residual disease or recurrence. Conclusions: The preliminary results show the interest of the PET/CT with {sup 18}F DOPA in the therapy follow-up and the management of patients suffering of medullary thyroid carcinoma in biological relapse. (N.C.)

  2. Rôle de la tomographie par émission de positrons avec le 18-fluoro-deoxyglucose (PET-FDG) dans la détection précoce d'une non-stérilisation tumorale des carcinomes bucco-pharyngo-laryngés

    Haenggeli, C. A.; Dulguerov, Pavel; Slosman, Daniel; Becker, Minerva; Bang, Pascal Ilhyun; Allal, Abdelkarim Said; Guyot, J. P.; Lehmann, Willy

    2000-01-01

    To evaluate and compare the performances of FDG-PET imaging, MRI and clinical examination in the detection of residual tumour 3 months after treatment of patients with head and neck squamous cell carcinoma.

  3. Impact of {sup 18}F-fluoro-deoxy-glucose positron emission tomography (F.D.G.-PET) in recurrent colorectal cancer; Evaluation de la TEP au {sup 18}F-F.D.G. dans l'exploration de la recidive des carcinomes colorectaux

    Metrard, G.; Morel, O.; Girault, S.; Soulie, P.; Guerin-Meyer, V.; Lorimier, G.; Gamelin, E. [Centre Paul-Papin, 49 - Angers (France); Metrard, G.; Jeanguillaume, C.; Berthelot, C.; Le Jeune, J.J. [Centre Hospitalier Universitaire, Service de Medecine Nucleaire, 49 - Angers (France); Parot-Schinkel, E. [Centre Hospitalier Universitaire, Service de Recherche Clinique, 49 - Angers (France)

    2009-09-15

    Purpose The aim of the study was to evaluate the diagnostic performance, the prognosis factors and the therapeutic impact of {sup 18}F-F.D.G. positron emission tomography (F.D.G.-PET) in the detection of recurrent colorectal cancers. Methods Sixty PET/CT with {sup 18}F-F.D.G. and CT were performed in 52 patients, at the Paul Papin cancer center between 2003 and 2005, following suspicion of colorectal cancer relapse. The F.D.G.-PET impact on the clinical management was studied by examination of multidisciplinary consultations results. Survival analysis were realized with a mean follow up of 2.2 years. Results Recurrence was confirmed for 50 explorations by histologic (n = 32), radiologic (n = 14) or clinical (n = 4) findings. Twenty patients died during the time of the study. On a patient based analysis, F.D.G.-PET sensitivity, specificity and overall accuracy were 90, 90, 90% respectively compared with 74, 50 and 70% for CT. F.D.G.-PET changed the clinical management in 18 cases (30%). A positive F.D.G.-PET signal, more than one hepatic lesion, more than two lymph node lesions detected on F.D.G.-PET and more than two hepatic lesions on CT were characterized as bad prognostic factors for survival. Multivariate analysis showed that the only independent bad prognostic factor was the F.D.G.-PET detection of more than two liver lesions. Conclusion These results confirmed the important impact of F.D.G.-PET in the clinical management of patients with a suspected recurrence of colorectal cancer. (authors)

  4. Evaluation of scintigraphy with {sup 111}In-labelled somatostatin in patients suspected of recurrence of thyroid differentiated carcinoma having negative {sup 131}I scintigraphy; Evaluation de la scintigraphie a la somatostatine marquee a l`indium 111 chez les patients suspects de recidive d`un carcinome differencie de la thyroide et dont la scintigraphie a l`iode 131 est negative

    Valli, N.; Leccia, F.; Fernandez, Ph.; Guyot, M.; Ducassou, D

    1997-12-31

    Thirty percents of the patients operated of thyroid carcinoma presented in their subsequent evolution a significant increase in the thyroglobulin (Tg) level without a metastatic focus detectable by {sup 131}I whole-body scintigraphy. Indeed, making evident these focuses is necessary in order to tackle their treatment. In this clinical context we have carried out retrospectively the evaluation of somatostatin scintigraphy. Seventeen patients (12F and 5M) of average age 48 years (from 26 to 76 years) presented a Tg significantly increased after treatment cessation, were subject to a scintigraphy associated to a cervico-thoracic tomography at 24 h after the injection of somatostatin (SS). All of them were subject to a osseous scintigraphy, a cervical echography by a scanner and/or to a cervical-thoracic MRI. The SS was positive in 5 patients, to a perfect concordance with the other conventional imaging techniques (CIT) in 3 cases. For the other two positive SS, in one case the SS has shown a cerebral focus which escaped to the other CIT, but was not able to evidence known osseous lesions, while in the other case a cervical localization was not find out by SS. As a matter of fact, in two patients the SS was negative while the CIT was positive. Finally, in 10 patients all the examinations remained negative. Hence, according to our experience the SS appear to be less contributive then the CIT

  5. Significado clínico-patológico das expressões citofotométricas do Ki-67 e Caspase-3 no carcinoma de células escamosas do esôfago Clinicopathologic significance of the Ki-67 and Caspase-3 cytophotometric expressions in the esophageal squamous cell carcinomal

    Gilmar Pereira Silva

    2008-06-01

    Full Text Available RACIONAL: A escolha da forma de tratamento do carcinoma de células escamosa de esôfago ainda hoje é orientada pelo estadiamento tumoral, onde as características histopatológicas do tumor são o maior determinante. Parale-lamente, desenvolvem-se estudos para entender o comportamento da biologia tumoral por método imunoistoquímico de quantificação manual, avaliando a ati-vidade proliferativa ou apoptótica do tecido em análise. As desvantagens conti-das no modo manual fizeram surgir e desenvolver método computadorizado de análise de imagem. OBJETIVOS: Verificar as expressões dos marcadores KI-67 e Caspase-3 e correlacioná-las com as características clínico-patológicas do tumor. MÉTODOS: Foram estudados 29 blocos parafinados provenientes de pa-cientes portadores de carcinoma de células escamosas de esôfago submetidos à esofagectomia e pertencentes a acervos de laboratórios de patologia. Proce-deu-se preparo das lâminas por técnica imunoistoquímica convencional. A quantificação da imunorreatividade às proteínas Ki-67 e Caspase-3 foi realizada pelo software de análise de imagem computadorizada SAMBA (Systeme d'Analyse Microphotometrique a Balayage Automatique através do índice de marcagem encontrado. RESULTADOS: Predominaram na amostra o sexo mascu-lino (82,7%; maiores de 50 anos; tumores moderadamente diferenciados (68,98%; estágio III (72,42%; lesões >3cm e localizadas no ⅓ inferior do ór-gão. Os índices médios de marcagem identificados foram de 62,05% para o Ki-67 e 86,06% para a Caspase-3, e não mostraram correlação com as caracterís-ticas clínico-patológicas como sexo, idade, estadiamento tumoral, grau de pro-fundidade da lesão e comprometimento linfonodal. Houve significante diferença de expressão do Ki-67 entre os graus histológicos (P=0,047 e correlação entre os índices dos marcadores estudados (r=0,41 e P =0,032. CONCLUSÃO: Na presente investigação as atividades das proteínas estudadas se mostraram in-tensas sendo que a da Caspase-3 foi superior ao Ki-67 mas sem correlação com as características clínico-patológicas.BACKGROUND: The esophageal squamous cell carcinoma treatment strategy is still based on the tumor staging, where tumor histopathologic charac-teristics are the major determinants. In parallel, studies have been developed in order to better understand the tumor biology using immunohistochemical meth-ods with manual quantification evaluating the proliferative and apoptotic activi-ties of the cells. The disadvantages related to the manual method rose the de-velopment of computerized ways to do the image analysis. OBJETIVES: To verify the expressions of the markers Ki-67 (proliferative and Caspase-3 (apoptotic and to correlate them with the clinic and pathologic characteristics of the tumor. METHODS: Twenty-nine paraffin embedded blocks were studied, each one con-taining tissue samples from patients with esophageal squamous cell carcinoma submitted to esophagectomies. The clinic and pathological data were obtained from histopathologic informations and from medical records. The slides were prepared following the routine immunohistochemical method until the point to utilize the specific antibodies (MIB-1 and CPP32. Positive quantification of the immunoreactivity to the proteins Ki-67 and Caspase-3 was performed by the software for computerized image analysis SAMBA (Systeme d' Analyse Micro-photometrique a Balayage Automatique. Statistical analysis was done having P3cm; and lesions located in the lower third of the organ. The mean score indexes found were 62.05% for Ki-67 and 86.06% for Caspase-3 and there was no correlation with the clinic or pathologi-cal characteristics as gender, age and tumor staging. There was significant dif-ference of Ki-67 expression among the histological grades (P=0.047 and corre-lation between the evaluated indexes (r=0.41 and P=0.032. CONCLUSION: The protein expressions were high and the Caspase-3 protein activity was higher than the Ki-67, without correlation with clinic or pathological characteristics as gender, age, tumor staging, grade of lesion depth and lymph node invasion.

  6. Survival over ten years after chemotherapy by paclitaxel and carboplatin, followed by a concomitant chemo-radiotherapy in nasopharyngeal undifferentiated carcinomas; Survie a dix ans apres chimiotherapie par paclitaxel et carboplatine, suivie d'une chimioradiotherapie concomitante dans les carcinomes indifferencies du nasopharynx

    Djekkoun, R.; Ferdi, N.; Bouzid, K. [CHU de Constantine, Constantine (Algeria)

    2011-10-15

    Based on 28 patients suffering from a cavum carcinoma and having been treated by neo-adjuvant chemotherapy (with paclitaxel and carboplatin) followed by a concomitant chemo-radiotherapy and an adjuvant chemotherapy, the authors analyse the response over time and identify the main causes of death. They also conclude that randomized studies are necessary to better asses the treatment efficiency. Short communication

  7. Irradiation of hepatocellular carcinoma: Impact of breathing on motions and variations of volume of the tumor, liver and upper abdominal organs; L'irradiation des carcinomes hepatocellulaires: impact de la respiration sur les mouvements et variations de volume de la tumeur, du foie et des organes intra-abdominaux

    Kubas, A.; Mornex, F.; D' Hombres, A.; Lorchel, F.; Chapet, O. [Centre hospitalier Lyon-Sud, Service de Radiotherapie-oncologie Rhone-Alpes, 69 - Pierre-Benite (France); Merle, P. [Hopital de l' Hotel-Dieu, Service d' Hepatogastroenterologie, 69 - Lyon (France)

    2008-12-15

    Purpose: To evaluate the amplitude of motion and the variations of volume of the tumor, the liver and upper abdominal organs induced by breathing during the irradiation of hepatocellular carcinoma (H.C.C.). Material and methods: Two scanners were performed in inhale and in exhale not forced in 20 patients with a H.C.C.. The liver (left/right lobes), the tumor, the duodenum, the two kidneys and the pancreas were delineated on each acquisition. The superposition of the two spirals made it possible to measure the displacements and variations of volume of these structures in the cranio caudal (C.C.), lateral (Lat), and anteroposterior (A.P.) directions. Results:The mean displacement of the tumour in C.C., Lat and A.P. was of 19.7 {+-} 8.3 mm, 4.5 {+-} 2.3 mm, and 8.9 {+-} 6.5 mm. The greatest amplitude of movement was obtained in C.C. for the right and left hepatic lobes (19 {+-} 6.5 mm, 10 {+-} 5.6 mm), the duodenum(12.6 {+-} 6.4 mm), the kidneys right and left (15.5 {+-} 6.1 mm, 16.2 {+-} 10 mm) and the pancreas (13.2 {+-} 6 mm). No significant variation of volume was observed for these organs. Conclusion: The movements of the tumour, the liver and the abdominal organs, induced by breathing are significant. The respiratory gating appears essential in particular with the development of new techniques of irradiation such as the intensity-modulated radiotherapy (I.M.R.T.) or the stereotactic body radiation therapy (S.B.R.T.). (authors)

  8. Concomitant chemoradiotherapy with folfox-cetuximab in stage III oesophagus and cardia carcinomas: final results of the phase-II Erafox study of the Gercor group; Chimioradiotherapie concomitante par folfox-cetuximab dans les carcinomes du cardia et de l'oesophage de stade III: resultats definitifs de l'etude de phase II Erafox du groupe Gercor

    Lledo, G.; Mammar, V.; Michel, P. [Hopital Jean-Mermoz, Lyon (France); Dahan, L. [CHU Rouen, Rouen (France); Mineur, L.; Dupuis, O. [Institut Sainte-Catherine, 84000 Avignon (France); Galais, M.P. [CHU Timone, Marseille (France); Chibaudel, B. [InstitutJean-Godinot, Reims (France); Jovenin, N. [Gercor, Paris (France); Gramont, A. de [Hopital Saint-Antoine, Paris (France)

    2011-10-15

    The authors report and discuss the results of a French national multicentre study which aimed at assessing the efficiency and tolerance of a folfox- and cetuximab-based chemotherapy concomitant with a radiotherapy for the treatment of stage-III cardia and oesophagus cancers. Patients (60 men and 19 women) have been selected according to the carcinoma type, performance index, age, weight loss over the last six months. Results are discussed in terms of response, steadiness, advancement, grade 3 and 4 toxicity, and side effects. The therapeutic efficiency corresponds to an objective response rate of 77 per cent, and tolerance profile seems to be acceptable for patients suffering from locally advanced cardia and oesophagus cancer. Short communication

  9. Combination of radiotherapy and cetuximab for patients suffering from of an advanced and non operable epidermoid carcinoma of the ORL sphere: results and side effects; Association de radiotherapie et de cetuximab chez des patients atteints d'un carcinome epidermoide de la sphere ORL evolue non operable: resultats et effets secondaires

    Acevedo, C.; Valette, G.; Bouchekoua, M.; Marianowski, R.; Pradier, O. [CHU Morvan, 29 - Brest (France)

    2010-10-15

    The authors report a retrospective survey of a set of locally advanced epidermoid carcinomas treated by irradiation and cetuximab. They assessed the response to the treatment, the specific survival, and the global survival as well as the tolerance. The survey is based on 31 men and 5 women suffering from different stage 4 non-metastatic advanced epidermoid carcinomas of the ORL sphere. Short communication

  10. Mediastinal radiotherapy after multidrug chemotherapy and prophylactic cranial irradiation in patients with SCLC - treatment results after long-term follow-up and literature overview; Radiotherapie mediastinale apres chimiotherapie et irradiation prophylactique de l'encephale chez des patients atteints d'un carcinome bronchique a petites cellules - Resultats et revue de la litterature

    Herrmann, M.K.A.; Bloch, E.; Overbeck, T.; Wolff, H.A.; Hille, A.; Hess, C.F.; Christiansen, H. [Department of Radiotherapy, University Hospital Goettingen, Robert-Koch-Str. 40, 37075 Goettingen (Germany); Koerber, W. [Department of Pneumology, Weende Hospital, Section Lenglern, Pappelweg 5, 37120 Bovenden-Lenglern (Germany); Vorwerk, H. [Department of Hematology and Oncology, University Hospital Goettingen, Robert-Koch-Str. 40, 37075 Goettingen (Germany); Muller, M.; Pradier, O. [Department de cancerologie, CHU Morvan, 5, avenue Foch, 29200 Brest cedex (France)

    2011-04-15

    Introduction. - Curative therapy for patients with small-cell lung cancer (SCLC) is based on multidrug chemotherapy combinations and radiotherapy. After a long time follow-up, the aim of the study was to evaluate the efficacy and toxicity of sequential chemo-radiotherapy and the effect of prophylactic cranial irradiation (PCI). Methods. - From 1995-2005, 96 patients with SCLC (64 limited-disease [LD], 32 extensive-disease [ED]; median age 61 years [range 39-79]) were treated at our department with varying chemotherapy regimens and sequential mediastinal radiotherapy (50 Gy + 10 Gy boost in case of residual disease after chemotherapy). Afterwards, 15 patients with LD, good general condition and at least partial response after local treatment received PCI (30 Gy). Results. - After a median follow-up of 78.6 months, 20 patients remained alive (20.8%, median survival time 18.2 months). The 2-/5-year overall survival rates were 33.8% and 12.6%, the 2-/5-year loco-regional control rates were 30.3% and 24.5%, respectively. Distant metastases occurred in 43 patients (24 cerebral). Cerebral metastasis occurred in 6.7% and 27.2% of the patients with PCI and without PCI respectively. Only tumor stage showed a statistically significant impact on overall survival and loco-regional control in multivariate analysis. Radiotherapy was well tolerated. Grade 3/4 toxicity occurred in seven patients. Prognosis of patients with SCLC remains poor. Administration of PCI in selected patients bears a decrease in the incidence of cerebral metastases. Alternative chemotherapy schemes as well as irradiation schemes and techniques should be the substance of future randomized trials. (authors)

  11. Tumors in the parotid are not relatively more often malignant in children than in adults

    Stevens, E; Andreasen, S; Bjørndal, K; Homøe, P

    2015-01-01

    carcinoma (n=4) followed by the mucoepidermoid carcinoma (n=3) and adenoid cystic carcinoma (n=2). The overall female-to-male ratio was 1.18, with a ratio of 1.08 and 2.0 in the benign and malignant groups, respectively. At the end of follow-up (August 1st, 2014) two patients had died, one with adenoid...

  12. Carninome intracanalaire (in situ) du sein : pouvons-nous raisonnablement viter la radiothrapie pour certaines patientes opres ?

    COUCKE, Philippe; BARTHELEMY, Nicole; JANSEN, Nicolas; Trivire, N.; JERUSALEM, Guy

    2008-01-01

    Dans le cadre de la prise en charge multidisciplinaire du carcinome intracanalaire du sein (carcinome intra-canalaire in situ = DCIS = Ductal Carcinoma In Situ), on voque souvent la possibilit de renoncer la radiothrapie complmentaire aprs un geste de chirurgie conservatrice. Sil est vrai que la radiothrapie, dans ce contexte, napporte pas de bnfice en survie, il nen reste pas moins quon observe long terme un effet bnfique en contrle local. Il existe un effet significativem...

  13. Elevated hepatocyte paraffin 1 and neprilysin expression in hepatocellular carcinoma are correlated with longer survival

    Mondada D.

    2006-01-01

    Rsum de l'article Le carcinome hpatocellulaire reste une tumeur maligne de mauvais pronostic. Le but de cette tude rtrospective est d'tudier l'expression immunohistochimique semi-quantitative d'Hep Par 1 (hepatocyte paraffin 1) et de CD 10 (CALLA ou neprilysin) et leur valeur pronostique sur un collectif de 97 patients avec un carcinome hpatocellulaire trait vise curative. Hep Par 1 ragit avec un pitope spcifique de l'hpatocyte au niveau de la membrane mitochondriale et se prs...

  14. Mammographic appearance of posttraumatic and postoperative leasons in the female breast simulating a tumor

    There are posttraumatic and postoperative leasons of the female breast which caused different pictures. You see sometimes typically pictures like lipid-filled thin-walled cysts with or without calcification of the walls. On the other side, there are mammographic pictures simulating a carcinoma - a differentiation between carcinoms and fat necrosis is in these cases not possible. (orig.)

  15. Lung-MAP Launches: First Precision Medicine Trial From National Clinical Trials Network

    A unique public-private collaboration today announced the initiation of the Lung Cancer Master Protocol (Lung-MAP) trial, a multi-drug, multi-arm, biomarker-driven clinical trial for patients with advanced squamous cell lung cancer. Squamous cell carcinom

  16. The use of the CELLection kit in the isolation of carcinoma cells from mononuclear cell suspensions

    Werther, K; Normark, M; Hansen, B F; Brünner, N; Nielsen, Hans Jørgen

    A study was performed to evaluate in vitro the sensitivity, specificity and variability of a new immunomagnetic microbead isolation technique which provides subsequent immunological staining of captured carcinoma cells. In a mixture of peripheral blood mononuclear cells (PBMCs) and human carcinom...

  17. Dicty_cDB: VSC863 [Dicty_cDB

    Full Text Available VS (Link to library) VSC863 (Link to dictyBase) - - - Contig-U16208-1 VSC863Z (Link to Original ... 4_1( BC076544 |pid:none) Danio rerio squamous cell carcinom ... 44 0.002 FN357917_9( FN357917 |pid:none) Schist ...

  18. SQUAMOUS CELL CARCINOMA OF NASAL VESTIBULE : A CASE REPORT

    Gayattre

    2015-04-01

    Full Text Available Various types of diseases can involve the nasal vestibule. Diagnosis and treatment of a nasal vestibular mass is often challenging due to the anatomical features of the nasal vestibule. Here, we report a histologically proven case of squamous cell carcinom a of nasal vestibule in a female patient.

  19. Dicty_cDB: FC-AE05 [Dicty_cDB

    Full Text Available FC (Link to library) FC-AE05 (Link to dictyBase) - - - Contig-U16208-1 FC-AE05E (Link to Origina ... 4_1( BC076544 |pid:none) Danio rerio squamous cell carcinom ... 74 4e-12 AF299060_1( AF299060 |pid:none) Tetrao ...

  20. SQUAMOUS CELL CARCINOMA OF NASAL VESTIBULE : A CASE REPORT

    Gayattre; Muniraju; Vidya

    2015-01-01

    Various types of diseases can involve the nasal vestibule. Diagnosis and treatment of a nasal vestibular mass is often challenging due to the anatomical features of the nasal vestibule. Here, we report a histologically proven case of squamous cell carcinom a of nasal vestibule in a female patient.

  1. Radio response of the lung after treatment of the mammary carcinoma with telecaesium - correlation with the dose-time relationship

    51 mamma carcinom patients underwent postoperative telecaesium irradiation (50 Gy). Chest radiograms were taken preceding the treatment and following it by eight to ten weeks. By reason of the results it can be supposed, that the unavoidable lung reaction due to radiotherapy can be decreased and partly avoided by adequate fractionation. (orig.)

  2. Dicty_cDB: VHH281 [Dicty_cDB

    Full Text Available VH (Link to library) VHH281 (Link to dictyBase) - G00540 DDB0216406 Contig-U16208-1 VHH281P (Lin ... 4_1( BC076544 |pid:none) Danio rerio squamous cell carcinom ... 69 2e-10 AK223016_1( AK223016 |pid:none) Homo s ...

  3. Dicty_cDB: VSB834 [Dicty_cDB

    Full Text Available VS (Link to library) VSB834 (Link to dictyBase) - - - Contig-U16208-1 VSB834Z (Link to Original ... 4_1( BC076544 |pid:none) Danio rerio squamous cell carcinom ... 54 2e-06 AY814260_1( AY814260 |pid:none) Schist ...

  4. CGP74514A Enhances TRAIL-induced Apoptosis in Breast Cancer Cells by Reducing X-linked Inhibitor of Apoptosis Protein

    Park, S.; Shim, S.M.; Nam, S.H.; Anděra, Ladislav; Suh, N.; Kim, I.

    2014-01-01

    Roč. 34, č. 7 (2014), s. 3557-3562. ISSN 0250-7005 R&D Projects: GA MŠk LH12202 Institutional support: RVO:68378050 Keywords : TRAIL * Apoptosis * Breast carcinom Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 1.826, year: 2014

  5. Pleursie massive aprs chirurgie du cancer de sein et arrt prcoce du Tamoxifne: propos dune observation

    Ngombe, Lon Kabamba; Kangulu, Ignace Bwana; Nday, Chantal Mwenze; Tshanda, Migrette Ngalula; Ngoy Lumbule, John; Matanga, Pierre Mbayo; Sampatwa, Olivier Ngoy; Nzaji, Michel Kabamba

    2014-01-01

    Nous rapportons un cas de pleursie massive droite probablement mtastasique accompagne d'un lymphdme du membre suprieur droit ayant fait suite une mastectomie et curage ganglionnaire indiqus pour un carcinome lobulaire du sein droit, associe un arrt prcoce de la prise de Tamoxifne, vcu Lubumbashi. PMID:25374634

  6. Analysis of the role of the gene coding the Amyloid-Precursor Protein Binding Protein 1 (APP-BP1) in the radio-sensitivity of epidermoid carcinomas of the upper aero-digestive tract infected by the human papillomavirus; Analyse du role du gene codant l'Amyloid-Precursor Protein Binding Protein 1 (APP-BP1) dans la radiosensibilite des carcinomes epidermoides des voies aero-digestives superieures infectees par le papillomavirus humain

    Guihard, S.; Altmeyer, A.; Ramolu, L.; Macabre, C.; Abecassis, J.; Noel, G.; Jung, A.C. [Centre de lutte contre le cancer Paul-Strauss, 67 - Strasbourg (France)

    2010-10-15

    As the human papillomavirus (HPV) is at the origin of 25% of upper aero-digestive tract cancers, and as these tumours present an increased radio-sensitivity compared to other tumours, probably due to a greater transcriptional activity of p53, the authors report the study on the influence of a decrease of the expression of the APP-BP1 in these tumours which could favour a radio-induced apoptosis. By using a reverse transcriptase polymerase chain reaction (RT-PCR), they assessed the APP-BP1 expression levels as well as expression levels of transcriptions coding onco-proteins known to be over-expressed in HPV+ tumours. They compared the radio-sensitivities of HPV+ and HPV- cells, the first one appearing to be greater than the second one. Short communication

  7. Drug: D06938 [KEGG MEDICUS

    Full Text Available D06938 Formula, Drug Keigairengyoto Scutellaria root [DR:D06688], Phellodendron bark [DR:D06689] ... ]) Empyema; Chronic rhinitis; Chronic adenoiditis; Acne ... Therapeutic category: 5200 Therapeutic category of ...

  8. Immunohistochemical study of androgen, estrogen and progesterone receptors in salivary gland tumors

    Fabio Augusto Ito

    2009-12-01

    Full Text Available The aim of this work was to study the immunohistochemical expression of androgen receptor, estrogen receptor and progesterone receptor in pleomorphic adenomas, Warthin's tumors, mucoepidermoid carcinomas and adenoid cystic carcinomas of salivary glands. A total of 41 pleomorphic adenomas, 30 Warthin's tumors, 30 mucoepidermoid carcinomas and 30 adenoid cystic carcinomas were analyzed, and the immunohistochemical expression of these hormone receptors were assessed. It was observed that all cases were negative for estrogen and progesterone receptors. Androgen receptor was positive in 2 cases each of pleomorphic adenoma, mucoepidermoid carcinoma and adenoid cystic carcinoma. In conclusion, the results do not support a role of estrogen and progesterone in the tumorigenesis of pleomorphic adenomas, Warthin's tumors, mucoepidermoid carcinomas and adenoid cystic carcinomas. However, androgen receptors can play a role in a small set of salivary gland tumors, and this would deserve further studies.

  9. Parotid carcinoma

    Sørensen, Kristine Bjørndal; Godballe, Christian; de Stricker, Karin; Krogdahl, Annelise

    2006-01-01

    OBJECTIVES: Our aim is to investigate the expression of kit protein (KIT) and epidermal growth factor receptor (EGFR) in parotid carcinomas in order to correlate the expression to histology and prognosis. Further we want to perform mutation analysis of KIT-positive adenoid cystic carcinomas....... PATIENTS AND METHODS: Formalin-fixed paraffin-embedded sections from 73 patients with parotid gland carcinomas were used for the study. The sections were stained with both KIT and EGFR polyclonal antibodies. Twelve KIT-positive adenoid cystic carcinomas were examined for c-kit mutation in codon 816....... RESULTS: Of all carcinomas 25% were KIT-positive and 79% were EGFR-positive. Ninety-two percentage of the adenoid cystic carcinomas were KIT-positive. None of the adenoid cystic carcinomas had mutations in codon 816 of the c-kit gene. CONCLUSION: Neither KIT- nor EGFR-expression seem to harbour...

  10. Undifferentiated salivary gland carcinomas

    Herbst, H.; Hamilton-Dutoit, S.; Jakel, K.T.; Niedobitek, G.

    2004-01-01

    , comprising malignant lymphomas, amelanotic melanomas, Merkel cell carcinomas, and adenoid cystic carcinomas, in particular in small biopsy materials. Because of the rarity of undifferentiated salivary gland carcinomas, the differential diagnosis should always include metastases of undifferentiated carcinomas...

  11. Hypertrophy, Tonsillar (Enlarged Tonsils) (For Parents)

    ... For Kids For Parents MORE ON THIS TOPIC Mononucleosis Tonsils and Tonsillectomies Peritonsillar Abscess Strep Throat Tonsillitis ... on Strep Throat Enlarged Adenoids Tonsils and Tonsillectomies Mononucleosis Peritonsillar Abscess Strep Throat Tonsillitis Contact Us Print ...

  12. X-Ray Exam: Neck (For Parents)

    ... swelling in the tissues around the vocal cords (croup). It can also help in diagnosing an infection ... ON THIS TOPIC CAT Scan: Neck Enlarged Adenoids Croup Sinusitis Getting an X-ray (Video) X-Ray ( ...

  13. Full Text Available ... on the lights and see where the snoring is coming from. Snoring occurs when the airway become ... and enlarged tonsils and adenoids Snoring by itself is not necessarily dangerous, but some snorers have such ...

  14. The role of adenotonsillar tissues as a reservoir for Helicobacter pylori and Helicobacter hepaticus

    Aliakbari, Iraj; Noohi, Saeidollah; Safavi, Seyed Abbas; Tabrizi, Ali Goljanian; Bolfion, Mehdi; Razaghi, Maryam; Goudarzi, Hossein; Dabiri, Hossein

    2011-01-01

    Aim The aim of current study is to investigate whether tonsillar and/or adenoid tissue of patients with chronic adenotonsillitis plays a reservoir role for Helicobacter pylori (H. pylori) or Helicobacter hepaticus (H. hepaticus). Background Recently, there have been arguments ragarding Helicobacter pylori (H. pylori) being reserved in adenotonsillar tissue. Patients and methods This study was performed with 90 patients with the diagnosis of chronic tonsillitis and adenoid hypertrophy, mean ag...

  15. Lateral cephalometry: A simple and economical clinical guide for assessment of nasopharyngeal free airway space in mouth breathers

    Navneet Grewal; Alkesh V Godhane

    2010-01-01

    Nasopharyngeal obstruction by adenoid enlargement is one of the main causes of mouth breathing. Cephalometric radiographs and rhinomanometric tests to evaluate nasal obstruction have been available for several decades. Various lines and areas have been interpreted by number of investigators to implicate the enlarged adenoid in a casual relationship with mouth breathing and the subsequent effect on vertical facial growth. The aim of this paper is to review lateral cephalometric tracing methods...

  16. Kyste hydatique du foie rompu dans la veine cave inférieure

    laalim, Said Ait; Ibn majdoub Hassani, Karim; Toughai, Imane; Oussaden, Abdelmalek; Kamaoui, Imane; Mazaz, Khalid; Taleb, Khalid Ait

    2011-01-01

    La rupture du kyste hydatique dans la veine cave inférieure est une complication rare et grave des kystes hydatiques hépatique. La manifestation la plus fréquente est l'embolie pulmonaire. L'hémorragie aigue intra-kystique survienne surtout en per-opératoire et elle est d’évolution dramatique. Le diagnostic est basé sur le scanner. Le traitement est chirurgical. Nous rapportons un cas clinique rare chez un patient de 38 ans, opéré en urgence pour un sepsis sur un kyste hydatique du foie compr...

  17. Lymphangioléiomyomatose pulmonaire de révélation inhabituelle au cours d'une sclérose en plaque

    Jaafoura, Neirouz Ghannouchi; Guigua, Ahmed; Zaghouani, Houneida; Atig, Amira; Bakir, Dajla; Khalifa, Mabrouk; Bahri, Fethi

    2015-01-01

    La lymphangioléiomyomatose pulmonaire est une pathologie rare de la femme jeune, caractérisée par une prolifération de cellules musculaires lisses immatures, aboutissant à la destruction kystique des poumons avec possibilité d’évolution vers l'insuffisance respiratoire chronique. La découverte est souvent fortuite lors de la prise en charge d'une autre pathologie pulmonaire. Son association à une sclérose en plaque n'a jamais été rapportée, de même que l'embolie pulmonaire in situ comme manif...

  18. Une étiologie rare de kyste médiastinal

    Hicham FENANE; Bouchikh, Mohamed; Maidi, El mehdi; Lamboni, Damsane; Achir, Abdellah; Ouchen, Fahd; Oyali, Mbola; Caidi, Mohamed; Aziz, Said Al; Benosman, Abdellatif

    2014-01-01

    Le goitre ectopique endothoracique est une maladie rare, il représente moins de 1% de l'ensemble des goitres endothoracique, son diagnostic positif est parfois difficile et repose sur les données de l'imagerie. Le traitement est chirurgical en raison des risques de compression et de dégénérescence maligne. Nous rapportant un cas particulier d'un goitre ectopique endothoracique prenant la forme d'une masse kystique du médiastin avec des signes de compression du nerf phrénique.

  19. Localisation humrale d'une tumeur cellules gantes rcidivantes ( propos d'un cas)

    Nader, Youssef; Serghini, Issam; Koulali, Idrissi Khalid; Salahi, Hicham; Galwia, Farid

    2015-01-01

    Les auteurs rapportent un cas de localisation rare d'une tumeur cellules gantes au niveau de la palette humrale du coude droit chez un militaire de 36 ans de sexe masculin, la radio standard montrait une image kystique ne soufflant pas la corticale. L'examen anatomo-pathologique a permis d tablir le diagnostic et le traitement a fait appel: au dbut a une Exrse chirurgicale totale et une greffe osseuse par un greffon iliaque de la totalit de la palette humral qui s'est complique 6 mois de recule d une rcidive locale. PMID:25995809

  20. Ulcere de Marjolin: complication redoutable des sequelles de brlures

    Ouahbi, S.; Droussi, H.; Boukind, S.; Dlimi, M.; Elatiqi, O.K.; Elamrani, M.D.; Benchamkha, Y.; Ettalbi, S.

    2013-01-01

    Summary Lulcre de Marjolin dsigne la transformation maligne dune cicatrice de brlure ou de toute autre plaie ou ulcration chronique. Le type histologique prdominant reste le carcinome pidermode, et il est caractris par son agressivit locale, des mtastases plus frquentes, un risque de rcurrence et une mortalit plus importante que les carcinomes pidermodes classiques. Notre travail est une tude rtrospective portant sur 21 cas dulcre de Marjolin, colligs au service de chirurgie plastique du CHU Mohammed VI de Marrakech, avec pour but de relever les aspects pidmiologiques, thrapeutiques et volutifs de cette pathologie. Lamlioration du pronostic ncessite non seulement un diagnostic et un traitement prcoce, mais surtout une attitude prventive qui consiste en des greffes cutanes prcoces et des soins rguliers de toute cicatrice de brlure. PMID:24799850

  1. Tumeur neuroendocrine mammaire primitive: propos d'un cas rare

    Laabadi, Kamilia; Jayi, Sofia; El Houari, Aziza; Tawfic, Harmouch; Bouguern, Hakima; Chaara, Hikmat; Melhouf, Abdilah; Amarti, Afaf

    2013-01-01

    Les carcinomes neuroendocrine primitifs du sein sont des tumeurs rares et reprsentent 2 5% des cancers mammaires. Nous rapportons le cas de localisation mammaire chez une patiente de 50 ans. Il s'agit d'une tumeur classe T4d N1 M0. La tumeur est suspecte radiologiquement. Une microbiopsie est ralise. Ltude anatomopathologique et immunohistochimique est en faveur d'une tumeur neuroendocrine primitive du sein grande cellules exprimant les rcepteurs progestroniques seulement. Vu le caractre inflammatoire de la tumeur une chimiothrapie est dmarre avec bonne volution clinique. A la fin de la chimiothrapie on prvoit de raliser une mastectomie avec curage axillaire et en fonction des rsultats dfinitifs, une radiothrapie. Une hormonothrapie sera envisage une 2me tude immunohistochimique sur la pice de mastectomie. Vu la raret des carcinomes neuroendocrines mammaires primitifs, il n'existe pas de standard thrapeutique et le pronostic demeure difficile dterminer. PMID:24772221

  2. The binding of plakoglobin to desmosomal cadherins: patterns of binding sites and topogenic potential

    1996-01-01

    Plakoglobin is the only protein that occurs in the cytoplasmic plaques of all known adhering junctions and has been shown to be crucially involved in the formation and maintenance of desmosomes anchoring intermediate-sized filaments (IFs) by its interaction with the desmosomal cadherins, desmoglein (Dsg), and desmocollin (Dsc). This topogenic importance of plakoglobin is now directly shown in living cells as well as in binding assays in vitro. We show that, in transfected human A-431 carcinom...

  3. Immunohistochemical expression of basement membrane laminin in histological grades of oral squamous cell carcinoma: A semiquantitative analysis

    R Shruthy; Sharada, P; Uma Swaminathan; B R Nagamalini

    2013-01-01

    Background and Objectives: To determine the immunohistochemical (IHC) localization of basement membrane component laminin in histological grades of oral squamous cell carcinoma (OSCC). The purpose of this study was to demonstrate the loss of continuity of the basement membrane in OSCC using an antibody directed against laminin using advanced polymer staining system. Materials and Methods: A total of 30 cases of OSCC: 10 cases of well differentiated squamous cell carcinom (WDSCC), 10 cases of ...

  4. [Tumor cell separation by cell saver and membrane filter passage].

    Wiesel, M; Güdemann, C; Staehler, G

    1991-06-01

    Definite suspensions of malignant cells from three human tumor cells lines (bladder, prostate and renal cell carcinom) were passed through a cell saver (Althin Mediplast) and a leucozyte removal filter (PALL RC 100) under standard conditions. The examination of the solutions did not detect any malignant cells at all. If investigations with malignant cells in the blood will confirm these results, the use of intraoperative autotransfusion in urological tumor surgery would be possible. PMID:1917056

  5. [Therapy of primary oat-cell carcinoma of the larynx (author's transl)].

    Dietz, R; Wilhelm, H J

    1978-12-01

    The case of primary oat-cell carcinom of the larynx with metastases in the thyreoid gland and paratracheal lymphnodes is reported on. The different methods of treatment are examined, used examples of the much more common oat-cell carcinoma of the lung. The applicability of the methods to oat-cell carcinoma of the larynx is discussed. Our treatment scheme of surgery and extended radiation is used if the tumor is known to be locally restricted. PMID:215859

  6. Morfologické změny při rozvoji kolorektálního karcinomu u myšího modelu indukovaného kombinovaným podáním azoxymethanu a dextransulfátu sodného

    Klimešová, Klára; Rossmann, Pavel; Kverka, Miloslav; Frolová, Lenka; Tlaskalová, Helena

    Hradec Králové : Bibliographia medica Čechoslovaca, 2006, s. 42-42. [Kongres českých a slovenských imunologů /11./. Hradec Králové (CZ), 25.10.2006-28.10.2006] R&D Projects: GA ČR GD310/03/H147 Institutional research plan: CEZ:AV0Z50200510 Keywords : colorectal carcinom * mouse model * azoxymethan Subject RIV: EE - Microbiology, Virology

  7. Synchronous Renal Cell Carcinoma and Gastrointestinal Malignancies

    Dafashy, Tamer J.; Cameron K. Ghaffary; Keyes, Kyle T.; Joseph Sonstein

    2016-01-01

    While renal cell carcinoma is the most commonly diagnosed neoplasm of the kidney, its simultaneous diagnosis with a gastrointestinal malignancy is a rare, but well reported phenomenon. This discussion focuses on three independent cases in which each patient was diagnosed with renal cell carcinoma and a unique synchronous gastrointestinal malignancy. Case 1 explores the diagnosis and surgical intervention of a 66-year-old male patient synchronously diagnosed with clear cell renal cell carcinom...

  8. Porocarcinome sudoral eccrine de la face: tumeur annexielle rare

    Lakouichmi, Mohammed; El Bouihi, Mohamed; Zrara, Ibtissam; Lahmiti, Saad; Hattab, Nadia Mansouri

    2013-01-01

    Le porocarcinome sudoral eccrine est une tumeur cutane maligne point de dpart glande sudorale. Un homme de 48 ans s'est prsent la consultation avec une lsion simulant un carcinome basocellulaire de la tempe droite. La biopsie de cette lsion a rvl un porocarcinome eccrine. Le sige facial de cette tumeur est trs rare. Elle pose un problme diagnostique et thrapeutique. Nous discutons les diffrents aspects de cette tumeur avec revue de la littrature. PMID:23734280

  9. Gene deletion of inositol hexakisphosphate kinase 2 predisposes to aerodigestive tract carcinoma

    Morrison, BH; Haney, R; Lamarre, E; Drazba, J; Prestwich, GD; Lindner, DJ

    2009-01-01

    Inositol hexakisphosphate kinase 2 (IP6K2), a member of the inositol hexakisphosphate kinase family, functions as a growth suppressive and apoptosis-enhancing kinase during cell stress. We created mice with a targeted deletion of IP6K2; these mice display normal embryogenesis, development, growth and fertility. Chronic exposure to the carcinogen 4-nitroquinoline 1-oxide (4-NQO, a UV-mimetic compound) in drinking water resulted in fourfold increased incidence of invasive squamous cell carcinom...

  10. Analyse de la mthylation de l'ADN des cellules CD133+ dans le cancer du foie et son interaction avec la voie de signalisation TGF-b

    Martin, Marion

    2013-01-01

    Au sein des tumeurs, y compris pour le carcinome hpatocellulaire (CHC), des sous-populations de cellules noplasiques ont rvl une grande capacit initier de nouvelles tumeurs et induire des mtastases. Les premires tudes sur ces cellules ont rapidement montr que la prsence de ces cellules tait dterminante dans le dveloppement tumoral et elles ont donc t renommes " cellules souches cancreuses " (CSCs). Malheureusement les mcanismes impliqus dans la maintenance de ces CSCs ...

  11. Cell cycle break and apoptosis induction for the HPV-18 positive human head and neck carcinomas lines, after exposure to 5-fluorouracils and ionizing radiations:NF-kB implication in the radiosensitivity and spontaneous apoptosis; Arrets du cycle cellulaire et induction d'apoptose pour les lignees de carcinome humain de la tete et du cou HPV-18 positives, apres exposition au 5-fluorouracile et aux radiations ionisantes: implication de NF-kB dans la radiosensibilite et l'apoptose spontanee

    Didelot, C

    2002-04-15

    The P-53 protein holds an important contribution in the control of the cell cycle as well as the apoptosis control. But in numerous cancers the P-53 protein functionality is blocked by mutations or by its gene obliteration. The distribution of cells in the cell cycle as well as the apoptosis induction have been studied after exposure to 5-Fluorouracils (5-F.U.) or ionizing radiations. The two types of stress can induce dependent P-53 apoptosis after 5-F.U. exposure and independent P-53 apoptosis after ionizing radiation exposure. The P-53 protein is not the only one to have an important part in the cell cycle and apoptosis control, the transcription factor is important as well as the cells sensitivity to a stress such ionizing radiation. This could open new approaches of increasing the biological effects of ionizing radiations. (N.C.)

  12. Prospective study of factors of prognosis of survival without disease and of global five year and ten-year survival in a series of 90 patients suffering from a stage IIB or III cervical epidermoid carcinoma which had been treated by concomitant chemo-radiotherapy; etude prospective des facteurs pronostiques de survie sans maladie et de survie globale a cinq et dix dans une serie de 90 patientes atteintes d'un carcinome epidermoide du col uterin de stade IIB ou III dont le traitement etait une chimioradiotherapie concomitante

    Ferdi, N.; Djekkoun, R.; Aouati, E.; Chirouf, A.; Aouati, S.; Afiane, M. [CHU de Constantine (Algeria)

    2011-10-15

    The authors report the study of some factors (TNM stage, tumour size, histological sub-type and haemoglobin concentration) of survival without disease and of global survival by analyzing the files of 90 patients who had chemotherapy concomitantly with external radiotherapy (five 1,8 Gy sessions a week for four to five weeks) followed by utero-vaginal curietherapy. It appears that chemo-radiotherapy is well tolerated and that some factors very significantly affect global survival and survival without disease. Concomitant chemo-radiotherapy significantly delays the occurrence of recurrence and metastases, notably for locally advanced tumours. Short communication

  13. Salivary gland carcinomas of the larynx

    Nielsen, Troels Krogh; Bjørndal, Kristine; Krogdahl, Annelise; Primdahl, Hanne; Kristensen, Claus Andrup; Andersen, Elo Verner; Godballe, Christian

    2012-01-01

    a review of literature from 1991 to 2010 was performed. RESULTS: Six Danish patients with a malignant salivary gland tumor in the larynx were identified resulting in an incidence of 0.001/100,000 inhabitants/year. Four had adenoid cystic carcinoma and two a mucoepidermoid carcinoma. All patients....... The male vs. female ratio was 2:1, the most common location was the supraglottic region (52%) and the most predominant histological subtypes were adenoid cystic carcinoma (46%), mucoepidermoid carcinoma (35%) and adenocarcinoma NOS (12%). CONCLUSION: Laryngeal salivary gland carcinoma is a rare...

  14. Salivary gland carcinoma in Denmark 1990-2005: a national study of incidence, site and histology. Results of the Danish Head and Neck Cancer Group (DAHANCA)

    Bjørndal, Kristine; Krogdahl, Annelise; Therkildsen, Marianne Hamilton; Overgaard, Jens; Johansen, Jørgen; Kristensen, Claus Andrup; Homøe, Preben; Sørensen, Christian Hjort; Andersen, Elo Verner; Bundgaard, Troels; Primdahl, Hanne; Lambertsen, Karin; Andersen, Lisbeth Juhler; Godballe, Christian

    2011-01-01

    years. The parotid gland was the most common site (52.5%) followed by the minor salivary glands of the oral cavity (26.3%). The most frequent histological subtypes were adenoid cystic carcinoma (25.2%), mucoepidermoid carcinoma (16.9%), adenocarcinoma NOS (12.2%) and acinic cell carcinoma (10.2%). The...... revision process changed the histological diagnosis in 121 out of 886 cases (14%). The incidence of salivary gland carcinoma in Denmark is higher than previously reported. More than half of salivary gland carcinomas are located in the parotid gland with adenoid cystic carcinoma being the most frequent...

  15. Kyste hydatique pancratique: propos d'un cas

    Eljai, Rifki Saad; Boufettal, Rachid; Farah, Robleh Hassan; Chehab, Farid

    2015-01-01

    La localisation pancratique du kyste hydatique est rare, mme dans les pays ou la maladie hydatique svit ltat endmique. Il ne reprsentant que moins de 1% de l'ensemble des localisations.La symptomatologie souvent insidieuse aprs une longue volution, dpend du sige du kyste hydatique, ce qui peut expliquer les difficults du diagnostic, prtant confusion avec les autres lsions kystiques du pancras. Elle touche exceptionnellement l'enfant. Nous rapportons une observation survenue chez une patiente de 20 ans, victime il y'a 3 ans d'un traumatisme ferm de l'abdomen, qui prsentait depuis 2 mois des pigastralgies isoles, avec ictre. A travers cette observation et une revue de la littrature, nous discutons les difficults diagnostiques et les modalits du traitement chirurgical de cette localisation inhabituelle de la maladie hydatique. PMID:26587123

  16. Kyste hydatique du pancréas révélé par une pancréatite aigüe: à propos d'un cas

    Mohamed, Hedfi; Azza, Sridi; Chrif, Abdelhedi; Karim, Sassi; Adnen, Chouchen

    2015-01-01

    La localisation pancréatique du kyste hydatique est exceptionnelle, même dans les pays où la maladie hydatique sévit à l’état endémique. Nous rapportons une observation de kyste hydatique du pancréas révélée par une pancréatite aigue. Le diagnostic était porté sur les données du scanner abdominal qui objectivait une masse kystique de la queue du pancréas adhérente au hile splénique. Le traitement chirurgical avait consisté en une splénopancréatectomie gauche. A travers cette observation et un...

  17. Neurocysticercose révélée par une épilepsie réfractaire: à propos d'une observation

    Bugeme, Marcellin; Mukuku, Olivier

    2015-01-01

    Nous rapportons une observation de neurocysticercose parenchymateuse chez un homme de 38 ans, consommant régulièrement la viande de porc, qui a présenté une épilepsie réfractaire. Le diagnostic de NCC était basé sur la présence de lésions kystiques montrant le scolex sur les images du scanner cérébrale, la présence de signes cliniques évocateurs de NCC (épilepsie faite des crises convulsives focales évoluant vers des crises bilatérales), la réponse clinique au traitement à l'albendazole et le...

  18. Mucocle appendiculaire: propos d'un cas observ Lubumbashi

    Wakunga, Eric; Mukuku, Olivier; Bugeme, Marcellin; Tshiband, Mose; Kipili, Audifax; Mobambo, Pitchou; Arung, Willy; Wakunga, Warach

    2014-01-01

    La mucocle appendiculaire est une entit pathologique rare, mais potentiellement dangereuse, elle se prsente sous diffrentes formes cliniques. Nous rapportons ici un cas d'une patiente ge de 49 ans sans antcdents chirurgicaux chez qui nous avons dcouvert d'une faon fortuite cette affection. La clinique tait celle d'un syndrome appendiculaire aigu patent et elle rvlait une masse dans la fosse iliaque droite. Les examens de laboratoire ont montr une hyperleucocytose et une vitesse de sdimentation augmente. Lchographie a dmontr une masse kystique pricaecal. La patiente a subi une appendicectomie avec ccectomie partielle et la pice opratoire appendiculaire mesurait 153 mm de longueur et 64 mm de diamtre. L'analyse anatomopathologique de celle-ci a confirm le diagnostic de mucocle appendiculaire sans cellules de malignit. Les suites opratoires ont t simples et la patiente est sortie au cinquime jour postopratoire. PMID:25368725

  19. Les kystes hydatiques du foie rompus dans les voies biliaires: propos de 120 cas

    Moujahid, Mountassir; Tajdine, Mohamed Tarik

    2011-01-01

    Etude rtrospective rapportant une srie de kystes hydatiques rompus dans les voies biliaires colligs dans le service de chirurgie de l'hpital militaire Avicenne Marrakech. Entre 1990 2008, sur 536 kystes hydatiques du foie oprs dans le service, 120 taient compliqus de rupture dans les voies biliaires soit 22,38%. Il y avait 82hommes et 38 femmes. Lge moyen tait de 35 ans avec des extrmes allant de 10 60 ans. La clinique tait domine par la crise d'angiocholite ou une douleur du flanc droit. L'ictre tait isol dans huit cas. La fistule biliokystique tait latente dans plus de 50% des cas. Le traitement a consist en une rsection du dme saillant dans103cas (85,84%), une prikystectomie chez 11 malades (9,16%) et une lobectomie gauche dans six cas (5%). Le traitement de la fistule bilio kystique a consist en une suture chez 36malades et un drainage bipolaire dans 25 cas, La dconnexion kysto-biliaire ou choldocotomie trans hpatico kystique selon Perdomo tait pratique dans 49cas et une anastomose bilio-digestive choldoco-duodnale dans 10 cas. La dure moyenne d'hospitalisation tait de 20jours. Nous dplorons deux dcs par choc septique et un troisime par encphalopathie secondaire une cirrhose biliaire. La morbidit tait reprsente par huit abcs sous phrnique, douze fistules biliaires prolonges et deux occlusions intestinales. Les kystes hydatiques rompus dans les voies biliaires reprsentent la complication la plus grave de cette pathologie bnigne. Le traitement repose sur des mthodes radicales qui sont d'une efficacit reconnue, mais de ralisation dangereuse et les mthodes conservatrices, en particulier la dconnexion kysto-biliaire qui est une mthode simple et qui donne de bons rsultats court et long terme. PMID:22384289

  20. Esophagoscopy in Evaluating Treatment in Patients With Stage I-IV Head and Neck Cancer Who Are Undergoing Radiation Therapy and/or Chemotherapy

    2012-04-09

    Stage I Adenoid Cystic Carcinoma of the Oral Cavity; Stage I Mucoepidermoid Carcinoma of the Oral Cavity; Stage I Squamous Cell Carcinoma of the Hypopharynx; Stage I Squamous Cell Carcinoma of the Larynx; Stage I Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage I Verrucous Carcinoma of the Larynx; Stage I Verrucous Carcinoma of the Oral Cavity; Stage II Adenoid Cystic Carcinoma of the Oral Cavity; Stage II Mucoepidermoid Carcinoma of the Oral Cavity; Stage II Squamous Cell Carcinoma of the Hypopharynx; Stage II Squamous Cell Carcinoma of the Larynx; Stage II Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage II Verrucous Carcinoma of the Larynx; Stage II Verrucous Carcinoma of the Oral Cavity; Stage III Adenoid Cystic Carcinoma of the Oral Cavity; Stage III Mucoepidermoid Carcinoma of the Oral Cavity; Stage III Squamous Cell Carcinoma of the Hypopharynx; Stage III Squamous Cell Carcinoma of the Larynx; Stage III Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage III Verrucous Carcinoma of the Larynx; Stage III Verrucous Carcinoma of the Oral Cavity; Stage IV Adenoid Cystic Carcinoma of the Oral Cavity; Stage IV Mucoepidermoid Carcinoma of the Oral Cavity; Stage IV Squamous Cell Carcinoma of the Hypopharynx; Stage IV Squamous Cell Carcinoma of the Larynx; Stage IV Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage IV Verrucous Carcinoma of the Larynx; Stage IV Verrucous Carcinoma of the Oral Cavity

  1. Dasatinib in Treating Patients With Recurrent or Metastatic Malignant Salivary Gland Tumors

    2015-04-02

    High-grade Salivary Gland Mucoepidermoid Carcinoma; Low-grade Salivary Gland Mucoepidermoid Carcinoma; Recurrent Salivary Gland Cancer; Salivary Gland Acinic Cell Tumor; Salivary Gland Adenocarcinoma; Salivary Gland Adenoid Cystic Carcinoma; Salivary Gland Anaplastic Carcinoma; Salivary Gland Malignant Mixed Cell Type Tumor; Salivary Gland Poorly Differentiated Carcinoma; Salivary Gland Squamous Cell Carcinoma; Stage IV Salivary Gland Cancer

  2. Tumors of the lacrimal gland

    von Holstein, Sarah Linea; Rasmussen, Peter Kristian; Heegaard, Steffen

    2016-01-01

    , such as adenoid cystic carcinoma, the outlook is grave. Optimal treatment for several lacrimal gland tumors is also a matter of controversy. However, recent progress has been made in the molecular and genetic understanding of tumorigenesis for such lesions. This article presents an overview of the...

  3. Cancer of the external auditory canal

    Nyrop, Mette; Grøntved, Aksel

    2002-01-01

    adenoid cystic carcinoma. No patients with stage III or IV cancer were cured. All recurrences developed in patients with incompletely resected tumors. CONCLUSIONS: The outcome was related to the stage of disease, suggesting that the Pittsburgh staging system is useful also in patients with non...

  4. Osteopontin expression in salivary gland carcinomas

    Bjørndal, Kristine; Larsen, Stine R; Godballe, Christian; Krogdahl, Annelise

    2011-01-01

    :  Osteopontin was expressed in all salivary gland carcinomas. Adenoid cystic carcinomas had the highest mean sum score (7.3) and a significantly higher proportion of carcinomas with high OPN sum score than both mucoepidermoid carcinoma and acinic cell carcinoma. Correlation of OPN expression with known...

  5. The diagnostic difficulties in tracheal neoplasms; Trudnosci diagnostyczne w nowotworach tchawicy

    Bartnik, W.; Szewczyk, M.; Lomikowska, E.; Meler, M.; Rosolowska, J. [Wojewodzki Szpital Zespolony, Kalisz (Poland)

    1994-12-31

    Since 1990-1992 in the Dept. of ENT Kalisz 5 patients with tracheal neoplasms were treated. On the base of this cases the diagnostic difficulties has been presented. A rare case of tracheal carcinoma adenoides treated by telecobaltotherapy was described. 6 years survival rate was observed. (author)

  6. Simple mucin-type Tn and sialosyl-Tn carbohydrate antigens in salivary gland carcinomas

    Therkildsen, M H; Mandel, U; Christensen, M; Dabelsteen, E

    1993-01-01

    pleomorphic adenoma, when the malignant component was an adenocarcinoma. In contrast, acinic cell carcinomas and adenoid cystic carcinomas expressed only minimal amounts of Tn and sialosyl-Tn, and the staining was seen only in relation to the luminal membrane and mucin of a few glandular structures...

  7. K5/K14-positive cells contribute to salivary gland-like breast tumors with myoepithelial differentiation

    Boecker, Werner; Stenman, Goeran; Loening, Thomas; Andersson, Mattias K; Bankfalvi, Agnes; von Holstein, Sarah; Heegaard, Steffen; Lange, Alina; Berg, Tobias; Samoilova, Vera; Tiemann, Katharina; Buchwalow, Igor

    2013-01-01

    different cell lineages and define their cellular hierarchy in tumors with myoepithelial differentiation. isTILT analysis of a series of 28 breast, salivary, and lacrimal gland tumors, including pleomorphic adenomas (n=8), epithelial-myoepithelial tumors (n=9), and adenoid cystic carcinomas (n=11) revealed...

  8. Paediatric rhinitis

    Roberts, G; Xatzipsalti, M; Borrego, L M; Custovic, A; Halken, S; Hellings, P W; Papadopoulos, N G; Rotiroti, G; Scadding, G; Timmermans, F; Valovirta, E

    2013-01-01

    conditions such as adenoidal hypertrophy, septal deviation and nasal polyps. Examination by anterior rhinoscopy and allergy tests may help to substantiate a diagnosis of allergic rhinitis. Avoidance of relevant allergens may be helpful for allergic rhinitis (AR). Oral and intranasal antihistamines and nasal...

  9. Prevention of Communication Problems Associated with Cleft Palate.

    Pannbacker, Mary

    1988-01-01

    The paper reviews principles of preventative intervention and their application to communication problems associated with cleft palate. Ten specific suggestions (such as continuing professional education, identification of adenoidal atrophy, and prompt referral for secondary management) and activities are described. (Author/DB)

  10. Value of F-18-FDG PET/CT for determining malignant pleural effusion in patients with cancer

    Letovanec I.

    2012-01-01

    Objectif : Les épanchements pleuraux sont fréquents chez les patients porteurs de cancer et déterminer s'ils sont de nature tumorale ou non relève d'une grande importance clinique, particulièrement pour le groupe des carcinomes pulmonaires NON à petites cellules (NSCLC). Le PET/CT s'est montré d'une grande utilité et est actuellement indiscutablement reconnu comme outils nécessaire dans la prise en charge et notamment la stadification et le suivi des cancers, et particulièrement des cancers p...

  11. Disease: H00947 [KEGG MEDICUS

    Full Text Available cutaneous tumor of follicular structures. It occurs either in isolation or in conjunction with other symptoms such as myoto...018296 OMIM: 132600 PMID:11708952 (description) Tsao H. Genetics of nonmelanoma skin cancer. Arch Dermatol 1...cterized by cells resembling those of the hair follicle matrix and sometimes show differentiation to...) PMID:15606674 (description, gene) Lazar AJ, Calonje E, Grayson W, Dei Tos AP, Mihm MC Jr, Redston M, McKee PH Pilomatrix carcinom...H00947 Pilomatricoma; Epithelioma calcificans of Malherbe Pilomatricoma is a benign

  12. Adénocarcinome pulmonaire primitif: expérience d'un centre hospitalier tunisien

    Joobeur, Samah; Mribah, Hadhami; Saad, Ahmed Ben; Mhamed, Saoussen Cheikh; Mahou, Houda; Rouatbi, Naceur; EL KAMEL Ali

    2015-01-01

    La fréquence de l'adénocarcinome pulmonaire primitif est en nette augmentation au dépend des autres types histologiques de cancer bronchique primitif. En effet, il représente environ 40% des cas des carcinomes bronchiques non à petites cellules (CNPC). Il se distingue par certaines particularités. Décrire les aspects épidémiologiques, cliniques, thérapeutiques et évolutifs de l'adénocarcinome pulmonaire primitif. Etude rétrospective incluant 322 patients porteurs d'adénocarcinome pulmonaire p...

  13. Clear-cell carcinoma of the lung metastatic to the hamate: a case report.

    Nissenbaum, M; Kutz, J E; Lister, G D

    1978-01-01

    Metastatic lesions of the hand are uncommon. A report of a solitary metastasis to the hamate seems not to have appeared previously in the literature. A 46-year-old factory worker presented a rare tumor, clear-cell carcinom of the lung, metastasizing to an unusual location, the hamate. The symptoms simulated sympathetic dystrophy and diagnosis was delayed because of the late appearance of radiographic changes over 6 months after symptoms first appeared. Early bone scanning in patients with chronic pain may provide useful information prior to the appearance of X-ray changes. PMID:729257

  14. Mucoepidermoid Carcinoma Misdiagnosed as Palatal Odontogenic Infection: An Overview on the Differential Diagnosis of Palatal Lesions

    Brajdić, Davor; Virag, Mihajlo; Manojlović, Spomenka; Lukšić, Ivica; Franćeski, Dalibor; Biočić, Josip; Bošan-Kilibarda, Ingrid; Zajc, Ivan; Macan, Darko

    2010-01-01

    MUKOEPIDERMOIDNI KARCINOM POGREŠNO DIJAGNOSTICIRAN KAO ODONTOGENA UPALA. PREGLED DIFERENCIJALNE DIJAGNOZE NEPČANIH LEZIJA ----- Mucoepidermoidni carcinom (MEC) čini oko 30% malignih tumora žlijezda slinovnica i otprilike isto toliko ih nastaje u malim žlijezdama slinovnicama. Nepce je najčešća lokalizacija onih koji nastaju u malim žlijezdama slinovnicama. Bolesnik star 33 godine s nepčanim MEC-om neuspješno je liječen kao akutna odontogena upala, koja nije reagirala na endodontsko liječenje ...

  15. Lymphome malin non hodgkinien du cavum: protocoles thérapeutiques et facteurs pronostiques

    Ouraini, Saloua; Nakkabi, Ismail; Benariba, Fouad

    2015-01-01

    Le lymphome malin non hodgkinien est une entité histologique rare parmi les cancers du cavum, la plupart des tumeurs du nasopharynx étant des carcinomes indifférenciés ou Undifferencied Carcinoma of Nasopharyngeal Type (UCNT); Il pose souvent un problème de diagnostic positif clinique et histologique. La symptomatologie est généralement peu spécifique et la démarche étiologique repose sur la biopsie du cavum faite à l'examen endoscopique avec examen immuno-histochimique. Nous rapportons le ca...

  16. Apport de la microscopie electronique dans la compréhension des mécanismes d'interactions entre nanoparticules et cellules biologiques

    Rima, Wael

    2012-01-01

    Parmi les nanoparticules aptes à accompagner la radiothérapie en clinique, les nanoparticules à base d'oxyde de gadolinium paraissent pertinentes, de part leur multimodalité en imagerie et leur effet radiosensibilisant prouvé in vitro et in vivo. Cet effet de radiosensibilisation est exceptionnel notamment sur des cellules cancéreuses radiorésistantes de la lignée SQ20B (carcinome squameux tête et cou) et uniquement pour des doses modérées de nanoparticules (aux alentours de 0.6 mM en Gd). Le...

  17. Implication des micrRNAs-30 dans la dissémination métastatique des cellules tumorales de cancer du sein au site osseux

    Frackowiak, Agnieszka

    2015-01-01

    Les métastases osseuses sont des complications fréquentes du cancer du sein, responsables sur le plan clinique d'hypercalcémie, fractures osseuses et douleurs, pour lesquelles, il n'existe que des traitements palliatifs. Les cellules tumorales de carcinomes mammaires qui métastasent au site osseux expriment des gènes qui favorisent le tropisme osseux de ces cellules ainsi que leur ancrage et développement dans la moelle osseuse. Les mécanismes moléculaires sous-jacents à ces processus sont co...

  18. Disease: H00026 [KEGG MEDICUS

    Full Text Available malignancy and the fourth most common malignancy in women in the developed world after breast, colorectal and lung cancer. Two... types of endometrial carcinoma are distinguished with respect to biology and clinical course. Type-I carcinom...a is related to hyperestrogenism by association with endomet...a is unrelated to estrogen, associated with atrophic endometrium, frequent lack of estrogen and pr...tion. Cancer hsa05213 Endometrial cancer K-ras (mutational activation) [HSA:3845] [KO:K07827] beta-Caten

  19. Snail1 - the architect behind the matrix . Novel roles in desmoplastic microenvironments

    Stanisavljevi??, Jelena, 1981-

    2014-01-01

    Els carcinomes inicien la seva invasi?? segrestant la plasticitat innata de les c??l??lules afectades, tant les epitelials del tumor com les mesenquimals de l'estroma tumoral. El di??leg qu??mic i mec??nic rec??proc entre els fibroblasts de l'estroma i les c??l??lules de carcinoma promou d'una banda la transdiferenciaci?? de fibroblasts a miofibroblasts, i de l'altra, la transici?? epiteli-mesenquima (EMT). La primera part d'aquesta tesi aborda la descripci?? d???un complex de prote??nes, que...

  20. Transoral Robotic Surgery in Treating Patients With Benign or Malignant Tumors of the Head and Neck

    2015-03-26

    Recurrent Adenoid Cystic Carcinoma of the Oral Cavity; Recurrent Mucoepidermoid Carcinoma of the Oral Cavity; Recurrent Squamous Cell Carcinoma of the Hypopharynx; Recurrent Squamous Cell Carcinoma of the Larynx; Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity; Recurrent Verrucous Carcinoma of the Larynx; Recurrent Verrucous Carcinoma of the Oral Cavity; Stage 0 Hypopharyngeal Cancer; Stage 0 Laryngeal Cancer; Stage 0 Lip and Oral Cavity Cancer; Stage I Adenoid Cystic Carcinoma of the Oral Cavity; Stage I Mucoepidermoid Carcinoma of the Oral Cavity; Stage I Squamous Cell Carcinoma of the Hypopharynx; Stage I Squamous Cell Carcinoma of the Larynx; Stage I Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage I Verrucous Carcinoma of the Larynx; Stage I Verrucous Carcinoma of the Oral Cavity; Stage II Adenoid Cystic Carcinoma of the Oral Cavity; Stage II Mucoepidermoid Carcinoma of the Oral Cavity; Stage II Squamous Cell Carcinoma of the Hypopharynx; Stage II Squamous Cell Carcinoma of the Larynx; Stage II Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage II Verrucous Carcinoma of the Larynx; Stage II Verrucous Carcinoma of the Oral Cavity; Stage III Adenoid Cystic Carcinoma of the Oral Cavity; Stage III Mucoepidermoid Carcinoma of the Oral Cavity; Stage III Squamous Cell Carcinoma of the Hypopharynx; Stage III Squamous Cell Carcinoma of the Larynx; Stage III Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage III Verrucous Carcinoma of the Larynx; Stage III Verrucous Carcinoma of the Oral Cavity; Stage IV Squamous Cell Carcinoma of the Hypopharynx; Stage IVA Adenoid Cystic Carcinoma of the Oral Cavity; Stage IVA Mucoepidermoid Carcinoma of the Oral Cavity; Stage IVA Squamous Cell Carcinoma of the Larynx; Stage IVA Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage IVA Verrucous Carcinoma of the Larynx; Stage IVA Verrucous Carcinoma of the Oral Cavity; Stage IVB Adenoid Cystic Carcinoma of the Oral Cavity; Stage IVB Mucoepidermoid Carcinoma of the Oral Cavity; Stage IVB Squamous Cell Carcinoma of the Larynx; Stage IVB Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage IVB Verrucous Carcinoma of the Larynx; Stage IVB Verrucous Carcinoma of the Oral Cavity; Stage IVC Adenoid Cystic Carcinoma of the Oral Cavity; Stage IVC Mucoepidermoid Carcinoma of the Oral Cavity; Stage IVC Squamous Cell Carcinoma of the Larynx; Stage IVC Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage IVC Verrucous Carcinoma of the Larynx; Stage IVC Verrucous Carcinoma of the Oral Cavity; Tongue Cancer

  1. Inflammatory cytokine detection in adenotonsill and peripheral blood mononuclear cells- culture in adenotonsillectomy patients: a comparative study

    Farhadi M

    2013-04-01

    Full Text Available Background: Tonsils and adenoid hypertrophy is a major respiratory symptom in children which is partly due to recruitment of inflammatory cells in upper airway lymph nodes as a result of the effects of synthesis and release of different inflammatory cytokines. It seems that infections play role in concert with these cytokines leading to tonsilar hypertrophy and other pathologic consequences. It is proposed that cellular infiltrate of tonsils and adenoids may secrete different quantities of these cytokines compared with peripheral blood mononuclear cells (PBMC cultures.Methods: Among patients who were admitted for adenotonsillectomy to the ENT ward, 37 patients, under 1-12 years old patients with fulfill criteria selected to include the study. Excised adenoid and tonsils cultured and inflammatory cytokines Interferon-γ (INF-γ, Interlukine-1 (IL-1, IL-6, IL-8 and tumor necrosis factor-α (TNF-α measured in cellular culture supernatant. The same cytokines measured in PBMC cultures.Results: The data shows that there is a significant difference between IFN-γ and IL-8 amounts in adenoid tissue culture supernatant and PBMC culture of our patients. Furth-ermore, the amounts of IFN-γ, IL-1 and IL-8 showed considerable difference between tonsilar tissue culture supernatant and PBMC culture of these patients. Although there is a significant correlation between IL-6 amounts in tissue culture supernatant and PBMC culture (P=0.02, the respective data for TNF is only almost significant.Conclusion: Inflammatory cytokines may have significant role in the early provoke of inflammation occurred in hypertrophied tonsils and adenoid. The majority of these cyt-okines increase the expression of adhesion molecules on epithelial cells and influence the recruitment of leucocytes and inflamed tonsils. On the other hand lack of sufficient cytokine release may lead to persistent infections and may cause chronic inflammation and hypertrophied tissue.

  2. CT and MRI features of perineural tumor spreading along the trigeminal nerve in malignant head and neck tumors

    Objective: To study the imaging features regarding perineural spread of tumor along the trigeminal nerve in malignant head and neck tumors, investigate its usefulness in improving diagnostic accuracy and palnning for clinical treatment. Methods: Images in 9 patients with clinical or radiological findings suggestive of perineural spread along trigeminal nerve were retrospectively studied. Results: Among the 9 patients, 6 were adenoid cystic carcinoma of the hard palate (n=3), maxillary sinus (n=1), parotid gland (n=1) and buccal space (n=1), respectively. Two were nasopharyngeal carcinoma and 1 was squamous carcinoma of the maxillary sinus. Enlargement and fat effacement of greater palatine foramen and pterygopalatine fossa distant from primary diseases were seen in all the 3 patients with adenoid cystic carcinoma of the hard palate and 1 with squamous carcinoma of maxillary sinus, furthermore, enlargement of foramen ovale and invasion of meckal cave was seen in 1 case. Erosion of infraorbital foramen and enlargement of the pterygopalatine fossa was seen in 1 patient with adenoid cystic carcinoma of maxillary sinus. Enlargement of pterygopalsatine fossa and foramen rotundum and invasion of the Meckal cave were seen in 1 patient with adenoid cystic carcinoma of buccal space. Perineural spread along auriculotemporal nerve and intracranial invasion through foramen ovale were seen in 1 patient with adenoid cystic carcinoma of parotid gland. Enhancement of mandibular nerve was seen in 2 patients with nasopharyngeal carcinoma. Conclusion: Perineural tumor spread along trigeminal nerve can be seen in malignant head and neck tumors, and knowledge of the anatomy of trigeminal nerve and its surrounding structures is important for correct diagnosis. (authors)

  3. Male breast cancer: 22 case reports at the National Hospital of Niamey- Niger (West Africa Le cancer du sein chez l'homme: propos de 22 cas a l'Hpital National de Niamey- Niger (Afrique de l'Ouest

    Nouhou Hassane

    2009-11-01

    Full Text Available BACKGROUND: Male breast cancer (MBC is rare. The objective of the study is to report clinicopathological characteristics, treatment patterns, and outcomes of MBC. METHODS: This study, which includes two parts (retrospective and prospective, focused on all hospitalized male patients with breast cancer during 17 years (19922008 with histological confirmation. RESULTS: The series included 22 patients. The mean age was 52.8 years (range: 2880 years. MBC represented 5.7% of all breast cancers. Most patients had an advanced disease with skin ulceration and inflammation T3 (31.9% and T4 (59.1%. The majority of patients came from rural areas (63.6%. The duration of signs ranged from 1 to 7 years. Histology found infiltrating ductal carcinoma in 14 cases (63.6%, sarcoma in 3 cases (13.6%, papillary carcinoma in 2 cases (9%, and lobular carcinoma, medullar carcinoma, and mucinous carcinoma in 4.6% each of the others cases. The treatment had consisted of a radical mastectomy (Halsted or Patey in 19 cases (86.4% with axillary clearance and incomplete resection in 3 cases (13.6%. In the retrospective study follow-up of 14 patients, we lost sight of 13 patients 6 months after surgery. In the prospective study of 8 patients 10 to 36 months after mastectomy, 4 patients were deceased (50%, 4 were alive with 1 case having a local recurrence and pulmonary metastasis. CONCLUSION: The advanced clinical forms of MBC are most frequent with skin ulceration and nodal enlargement. The absence of radiotherapy and the low access of chemotherapy limited the treatment to radical mastectomy (Halsted in the majority of cases. OBJECTIF : Le cancer du sein chez lhomme (CSH est une affection rare .Le but de cette tude est de dterminer les caractristiques clinicopathologiques, les rsultats du traitement et lvolution du CSH. Mthodologie : Il sagit dtude comportant 2 volets (rtrospectif et prospectif. Etaient inclus tous les patients de sexe masculin prsentant un cancer de sein pendant 17 ans de 1992 2006 avec preuve histologique. RESULTATS : La srie comportait 22 cas. Lage moyen tait de 52,8 ans (Extrmes : 28 et 80 ans. Le CSH reprsentait 5,7% des cancers du sein. Les tumeurs taient cliniquement avances avec des formes ulcro-hmorragiques et inflammatoires T3 (31.9% and T4 (59.1%. La majorit des patients provenaient des zones rurales (63.6%. Les signes voluaient de 1 7 ans. Lexamen histologique a retrouv un carcinome canalaire infiltrant dans 14 cas (63,6%, le fibrosarcome dans 3 cas (13,6%, le carcinome papillaire dans 2 cas (9% et les autres types dans 1 cas chacun (4,6% : le carcinome lobulaire, carcinome mdullaire, le carcinome pidermode .La mastectomie radicale (Patey ou Halsted avec curage ganglionnaire axillaire t ralise dans 19 cas (86,4%, et dans 3 cas (13,6% une exrse incomplte. Lvolution : dans ltude rtrospective 13 patients perdus de vue 6 mois aprs la mastectomie. Dans ltude prospective aprs un recul de 10 36 mois il a t enregistr 4 dcs (50% et 4 patients sont vivant et un cas avec de rcidive locale et mtastases hpatiques. CONCLUSION : Le CSH est rare mais non exceptionnel. Le stade est volu au moment diagnostic et le pronostic est grave. Dans notre environnement la mastectomie radicale constitue dans la plupart des cas le seul moyen thrapeutique li au faible accs de la radio chimiothrapie.

  4. [Middle ear effusion and allergy in childhood].

    Bachert, C; Keilmann, A; Ganzer, U

    1989-04-01

    Besides mechanical or infectious factors in the genesis of secretory otitis media IgE-mediated hypersensitivity has often been discussed. In order to estimate the importance of an allergic reaction in the development of middle ear disease, we examined 27 children having adenoids and a secretory otitis media. We documented the patients' history of allergy and determined the IgE-levels in the serum, the middle ear effusions and the adenoid tissue. 5 out of 27 children suffered from an allergy of the upper respiratory tract, but only in one child we found an elevated level of IgE in middle ear effusion. On the basis of our investigations and recent literature, we suggest that an allergic rhinitis might cause an Eustachian tube dysfunction in a few patients. There is no evidence of a local allergic reaction of the middle ear mucosa. PMID:2742640

  5. Salivary gland carcinoma in Denmark 1990-2005: a national study of incidence, site and histology. Results of the Danish Head and Neck Cancer Group (DAHANCA)

    Bjørndal, Kristine; Krogdahl, Annelise; Therkildsen, Marianne Hamilton; Overgaard, Jens; Johansen, Jørgen Bjerregaard; Kristensen, Claus A; Homøe, Preben; Sørensen, Christian Hjort; Andersen, Elo; Bundgaard, Troels; Primdahl, Hanne; Lambertsen, Karin; Andersen, Lisbeth Juhler; Godballe, Christian

    2011-01-01

    years. The parotid gland was the most common site (52.5%) followed by the minor salivary glands of the oral cavity (26.3%). The most frequent histological subtypes were adenoid cystic carcinoma (25.2%), mucoepidermoid carcinoma (16.9%), adenocarcinoma NOS (12.2%) and acinic cell carcinoma (10.2%). The......To describe the incidence, site and histology (WHO 2005) of salivary gland carcinomas in Denmark. Nine hundred and eighty-three patients diagnosed from 1990 to 2005 were identified from three nation-wide registries. The associated clinical data were retrospectively retrieved from patient medical...... revision process changed the histological diagnosis in 121 out of 886 cases (14%). The incidence of salivary gland carcinoma in Denmark is higher than previously reported. More than half of salivary gland carcinomas are located in the parotid gland with adenoid cystic carcinoma being the most frequent...

  6. Fast neutron radiotherapy for advanced malignant tumors of the paranasal sinuses

    The radiotherapy of advanced and low grade tumors of the internal nose and paranasal sinuses is still a problem. The results of neutron therapy of 20 patients with advanced and low grade tumors are presented. These patients were treated between July 1977 and October 1988. The mean age of patients is 53 years. Ten patients had adenoid cystic carcinomas, three patients squamous cell carcinomas, one patient a mucinous cell carcinoma, two patients a low grade adenocarcinoma and four patients low grade sarcomas. Mean follow-up is 16 months. Local control could be achieved in eleven cases. The results show that adenoid cystic carcinomas, low grade adenocarcinomas and sarcomas benefit from neutron therapy. (orig.)

  7. Long-term prognosis of maxillary sinus malignant tumor patients treated by fast neutron radiation therapy

    From 1976 through 1990, 19 patients with maxillary sinus malignant tumor were treated with combination therapy consisting of maxillectomy and radiation of fast neutron. Fast neutron radiotherapy was performed at National Institute of Radiological Sciences. Eight patients had adenoid cystic carcinomas, three patients squamous cell carcinomas, one patient a carcinoma in pleomorphic adenoma, four patients fibrosarcomas, one patient osteosarcoma, one patient chondrosarcoma and one patient rhabdomyosarcoma. Fast neutron therapy after/before surgery was effective in fresh cases with T2-3N0M0 adenoid cystic carcinomas and sarcomas (except for fibrosarcoma). Nine patients were alive more than three years after treatment. And serious complications of fast neutron radiation therapy appeared in six of these nine patients. Visual impairment of opposite side occurred in four patients. Bone necrosis occured in one patient and brain dysfunction in one patient. (author)

  8. Radiotherapy in epithelial tumors of the parotid gland: Case presentation and literature review

    Ravasz, L.A.; Terhaard, C.H.; Hordijk, G.J. (University Hospital Utrecht (Netherlands))

    1990-07-01

    A group of 113 patients irradiated for parotid tumor was studied retrospectively. Sixty-two patients were irradiated after superficial parotidectomy or enucleation of a pleomorphic adenoma. None of them had a recurrence after 5-15 years. Sixteen patients were irradiated postoperatively after surgery for a recurrence of pleomorphic adenoma. Only one of them had developed a recurrent tumor. Thirty-five patients with a malignant parotid tumor were treated by irradiation, 22 after surgery and 13 after biopsy only. Patients with a low malignancy tumor (10/11) and adenoid cystic carcinoma (6/12) responded better than patients with a high malignancy carcinoma (2/12). A tumor larger than 4 cm, facial nerve palsy, lymph node metastasis, and inoperability indicate a poor prognosis. With high dose radiotherapy it is possible to treat inoperable tumors successfully. Adenoid cystic carcinomas can respond well to irradiation alone.43 references.

  9. Oral epithelial cells are susceptible to cell-free and cell-associated HIV-1 infection in vitro

    Epithelial cells lining the oral cavity are exposed to HIV-1 through breast-feeding and oral-genital contact. Genital secretions and breast milk of HIV-1-infected subjects contain both cell-free and cell-associated virus. To determine if oral epithelial cells can be infected with HIV-1 we exposed gingival keratinocytes and adenoid epithelial cells to cell-free virus and HIV-1-infected peripheral blood mononuclear cells and monocytes. Using primary isolates we determined that gingival keratinocytes are susceptible to HIV-1 infection via cell-free CD4-independent infection only. R5 but not X4 viral strains were capable of infecting the keratinocytes. Further, infected cells were able to release infectious virus. In addition, primary epithelial cells isolated from adenoids were also susceptible to infection; both cell-free and cell-associated virus infected these cells. These data have potential implications in the transmission of HIV-1 in the oral cavity

  10. Assessment of nasal obstruction with flexible nasal endoscopy

    Objective was to report the value of nasal endoscopy as an outpatient procedure in the diagnosis of posterior nasal obstruction. Over one year period, from March 2002 to March 2003, we evaluated 130 adult patients that attended the Ear, Nose and Throat Department of Sohag University Hospital in Egypt with persistent nasal obstruction via anterior rhinoscopy and flexible nasopharyngoscopy. We reported the cause and site of obstruction in relation to the choanae. We confirmed the diagnosis by CT scanning, rigid endoscopic examination under general anesthesia, and histopathological analysis of biopsies taken. Forty-six percent of our cases had posterior nasal obstruction, 43.5% due to post-choanal lesions (mainly adenoid), 33% due to pre-choanal lesions (mainly choanal polyps), and 23.5% due to choanal lesions (mainly choanal adenoid). We conclude that flexible nasal endoscopy is superior to visual examination in the evaluation of nasal obstruction; hence, we recommend its routine use. (author)

  11. Coblation adenoidectomy our experience

    Balasubramanian Thiagarajan

    2014-03-01

    Full Text Available Aim of our study is to compare the efficacy and safety of coblation adenoidectomy versus conventional cold steel adenoidectomy. The study design included 40 children between age groups 4 – 8. Twenty of these children underwent coblation adenoidectomy while the other group of 20 underwent conventional cold steel adenoidectomy. The parameters taken into consideration for comparison included Post operative pain, operating time, intraoperative bleeding and presence of residual adenoid tissue 6 weeks after surgery. In this study the coblation group demonstrated less post operative pain, less intraoperative bleeding and more complete removal of adenoid tissue. Operative time was found to be significantly higher in coblation group when compared to conventional cold steel adenoidectomy group.

  12. A histopathological study of lung cancer and other pulmonary malignant tumors in people exposed to the atomic bomb and non-exposed people in Hiroshima Pref

    During cancer is likely to be more prevalent among A-bomb survivors based on epidemiological statistics. The histopathological classification of lung cancer was studied in 238 cases (57 exposed and 181 non-exposed) with onset in a period 1973 - 1977. None of the exposed patients had carcinoid, adenoid cystic carcinoma or mucoepidermoid carcinoma probably originating in the bronchial gland. Most of the exposed patients were slightly older than the non-exposed. Adenocarcinoma was more frequent among the exposed. (Chiba, N.)

  13. Histopathological study of lung cancer and other pulmonary malignant tumors in people exposed to the atomic bomb and non-exposed people in Hiroshima Pref

    Yamada, Akira (Hiroshima Prefecture (Japan))

    1983-04-01

    During cancer is likely to be more prevalent among A-bomb survivors based on epidemiological statistics. The histopathological classification of lung cancer was studied in 238 cases (57 exposed and 181 non-exposed) with onset in a period 1973-1977. None of the exposed patients had carcinoid, adenoid cystic carcinoma or mucoepidermoid carcinoma probably originating in the bronchial gland. Most of the exposed patients were slightly older than the non-exposed. Adenocarcinoma was more frequent among the exposed.

  14. The correlation between tonsil size and academic performance is not a direct one, but the results of various factors

    Kargoshaie, AA; Najafi, M; Akhlaghi, M; Khazraie, HR; Hekmatdoost, A

    2009-01-01

    Chronic upper airway obstruction most often occurs when both tonsils and adenoid are enlarged but may occur when either is enlarged. Obstructive sleep syndrome in young children has been reported to be associated with an adverse effect on learning and academic performance. The aim of this study was to evaluate the effect of relative size of the tonsil on academic performance in 4th grade school children. In 320 children, physical examination to determine the size of tonsils was performed by t...

  15. The bacterial interactions in the nasopharynx of children receiving adenoidectomy

    Chen, Hao-Xiang; Lai, Chih-Ho; Hsu, Hui-Ying; Huang, Ju-Chun; Wu, Hua-Shan; Ho, Mao-Wang; Tsai, Ming-Hsui; Lin, Chia-Der

    2015-01-01

    Staphylococcus aureus, Streptococcus pneumoniae, and Haemophilus influenzae are the common pathogens that colonize in the nasopharynx of children. Polymicrobial interactions are thought to play an important role in different sites throughout the human body. However, there are currently very few studies that investigate the interactions between S. aureus, S. pneumoniae, and H. influenzae in the nasopharynx. We retrospectively analyzed the adenoid tissue culture from 269 children who received a...

  16. Otitis media con efusión: estudio de casos y controles Otitis media with effusion: study of cases and controls

    Sonia Grisales

    1992-01-01

    Full Text Available Se realizó un estudio en 66 niños y 34 niñas de 2 a 12 años. Cincuenta fueron casos de otitis media con efusión (OME y 50 controles. El grupo etario más numeroso fue el de dos años. Los síntomas y signos más frecuentes fueron otalgia y fiebre (70% e hipoacusia (40%. Veintinueve casos (58% y sólo 12 controles (24% presentaron adenoides hipertróficas (p < 0.01 . La pérdida auditiva fue significativamente mayor en el grupo de casos y las curvas timpanométricas se relacionaron directamente con ella. No se demostró que la alergia fuera un elemento importante en la génesis de la OME, a diferencia de la hipertrofia de adenoides que constituyó nuestro hallazgo más importante.

    Between July 1988 and May 1989 we studied 100 children aged2-14 years; there were fifty cases of otitis media with effusion (OME and fifty controls. Each group Included 33 boys and 17 girls. The predominant age group was 2 years. The most frequent clinical manifestations of OME were earache and fever (70% each and reduced hearing (40%. In 29 cases (58% and in only 12 controls (24% enlarged adenoids were found (p < 0.01 . impaired hearing was significantly most frequent In the cases and the tympanometric curves had direct relationship with reduced hearing. Despite Its high prevalence allergy was not found to be of importance In the etiology of OME; by contrast, enlarged adenoids were the most relevant determinant of this disease In our series.

  17. Influence of Mouth Breathing on the Dentofacial Growth of Children: A Cephalometric Study

    Basheer, Bahija; Hegde, K Sundeep; Bhat, Sham S.; Umar, Dilshad; Baroudi, Kusai

    2014-01-01

    Background: The involvement of mouth breathing, facial, and structural growth alterations, especially during childhood has been discussed in medical and dental literature. The relevance of airway obstruction and its assumed effect on facial growth continues to be debated. Materials and Methods: This study was aimed at assessing the dental and soft tissue abnormalities in mouth breathing children with and without adenoid hypertrophy. Fifty children aged between 6 and 12 years following otolary...

  18. Effect of etiology of mouth breathing on craniofacial morphology

    Mohammadreza Majidi; Nadia Hasanzadeh; Navid Noorizadeh; Mohammad taghi Shakeri

    2008-01-01

    Introduction: Nasal septal deviation and hypertrophy of the adenoids and palatine tonsils are two common causes of nasopharyngeal obstruction and consequently mouth breathing in children. It is accepted that chronic mouth breathing influences craniofacial growth and development. The aim of this study was to evaluate the differences of craniofacial morphology in children with two different etiological factors of mouth breathing. Materials and Methods: Study design: cross sectional. The researc...

  19. Replacement of Missing Anterior Teeth in a Patient with Chronic Mouth Breathing and Tongue Thrusting

    Haralur, Satheesh B.; Ali Saad Al-Qahtani

    2013-01-01

    The loss of anterior teeth has serious functional, esthetic disabilities, in addition to compromising the patients' quality of life. Various etiologies can be attributed to the anterior tooth loss, including trauma, caries, and periodontal diseases. The chronic mouth breathing due to nasal adenoids is known to enhance the gingival and periodontal diseases. The dental literature proves the association of nasal breathing, tongue thrusting, and anterior open bite. Arch shape and tooth position a...

  20. Imaging of nasopharyngeal cysts and bursae

    Cysts and bursae of the nasopharynx are uncommon and seldom symptomatic when compared with malignant tumors of this region. However, it is noteworthy that in the presence of symptoms, a good knowledge of their radiological appearance is useful to establish the correct diagnosis. Cysts of Rathke's pouch, pharyngeal bursa of Luschka, Tornwaldt's cysts, retentional cysts of the seromucinous glands, oncocytic cysts, intra-adenoid cysts, branchial cysts, prevertebral or retropharyngeal abscess and pseudocysts of the nasopharynx will be discussed in this paper. (orig.)

  1. Resection and reconstruction of the carina

    We report the case of a 45 year old woman who presented with dyspnoea and cough since two years ago, the bronchoscopy showed a neoplastic lesion in the distal trachea affecting the carina, the histopathologic study confirmed an adenoid cystic carcinoma, we describe the preoperatory evaluation, the anesthetic procedures, and the surgical techniques used to resects and reconstruct the carina, this is the first case published in the national literature about the resection and reconstruction of the carina

  2. Minimally Invasive Tracheal Resection: Cervical Approach Plus Video-Assisted Thoracoscopic Surgery.

    Lonie, Sarah J; Ch'ng, Stephanie; Alam, Naveed Z; Wright, Gavin M

    2015-12-01

    Tracheal resection for adenoid cystic carcinoma (ACC) is a well-documented procedure. Surgical resection of these lesions offers patients the greatest potential chance of survival. Midtracheal tumors are usually resected through a maximally invasive sternotomy or thoracotomy. We report a midtracheal resection of a symptomatic ACC in a 25-year-old man by video-assisted thoracoscopic hilar release and suprasternal anastomotic approaches. The patient's recovery was complicated by chylothorax and pneumonia. PMID:26652526

  3. Management of difficult airway in intratracheal tumor surgery

    Agarwal Surendra K; Tewari Prabhat; Tyagi Isha; Goyal Amit; Syal Rajan

    2005-01-01

    Abstract Background Tracheal malignancies are usual victim of delay in diagnosis by virtue of their symptoms resembling asthma. Sometimes delayed diagnosis may lead to almost total airway obstruction. For difficult airways, not leaving any possibility of manipulation into neck region or endoscopic intervention, femorofemoral cardiopulmonary bypass can be a promising approach. Case Presentation We are presenting a case of tracheal adenoid cystic carcinoma (cylindroma) occupying about 90% of th...

  4. [Adenotonsillectomy in children only under exceptional circumstances].

    van den Bosch, W J H M; van de Lisdonk, E H

    2005-09-10

    More and more evidence is becoming available that throws doubt on the value of adenotonsillectomy in children with frequent throat infections or hypertrophic tonsils and adenoids. Tonsillectomy and adenoidectomy have a limited range of indications. Objective symptoms such as the size of the tonsils and subjective symptoms of obstruction and sore throat are not always related to each other. Children with only moderate symptoms should not be operated on. PMID:16184943

  5. Intravoxel incoherent motion MRI: emerging applications for nasopharyngeal carcinoma at the primary site

    Zhang, Shui-xing; Jia, Qian-jun; Liang, Chang-hong; Chen, Wen-bo; Qiu, Qian-hui; Li, He [Guangdong Academy of Medical Sciences/Guangdong General Hospital, Department of Radiology, Guangzhou, Guangdong Prov. (China); Zhang, Zhong-ping [Applied Science Lab, Guangzhou, Guangdong Prov. (China)

    2014-08-15

    We compared pure molecular diffusion (D), perfusion-related diffusion (D*), perfusion fraction (f) and apparent diffusion coefficient (ADC) based on intravoxel incoherent motion (IVIM) theory in patients with nasopharyngeal carcinoma (NPC). Sixty-five consecutive patients (48 men) with suspected NPC were examined using a 3.0-T MR system. Diffusion-weighted imaging (DWI) was performed with 13 b values (range, 0-800 s/mm{sup 2}). We regarded the result of endoscopy and biopsy as the gold standard for detection. D, D* and f were compared between patients with primary NPC and enlarged adenoids. IVIM DWI was successful in 37 of 40 NPC and 23 of 25 enlarged adenoids cases. D (P = 0.001) and f (P < 0.0001) were significantly lower in patients with NPC than in patients with enlarged adenoids, whereas D* was significantly higher (P < 0.0001). However, the ADC was not significantly different between the two groups (P > 0.05). The area under the ROC curve (AUC) for D was 0.849 and was significantly larger than that for ADC (P < 0.05). IVIM DWI is a feasible technique for investigating primary NPC. D was significantly decreased in primary NPC, and increased D* reflected increased blood vessel generation and parenchymal perfusion in primary NPC. (orig.)

  6. Radiation therapy for carcinoma of the major salivary glands

    From January 1967 through November 1991, a total of 135 patients with carcinoma of the major salivary glands (parotid: 95; submandibular: 39, sublingual: 1) were treated at our department. 40 patients had adenocarcinoma, 29 adenoid cystic carcinoma, 24 mucoepidermoid carcinoma and 16 squamous cell carcinoma. 100 patients were irradiated postoperatively and the remaining 35 were treated with radiation alone. Total radiation doses delivered were 50 Gy for the postoperative group and 50 to 66 Gy for the group receiving only radiation using a 60Co single portal with or without wedged paired or single electron portal boost. Actuarial five-year survivals after radiation therapy were 55% for the postoperative group and 26% for radiation only group (p=0.0004). The local control rates for the postoperative group were 83% for adenocarcinoma, 81% for adenoid cystic carcinoma, 83% for mucoepidermoid carcinoma and 62% for squamous cell carcinoma. Corresponding figures for the radiation only group were 40% for adenocarcinoma, 38% for adenoid cystic carcinoma and 33% for mucoepidermoid carcinoma. Conventional irradiation techniques continue to play an important role because they offer superior local control for postoperative patients with carcinoma of the major salivary glands. However, the local control rates for the radiation only group were only 30 to 40%, so that new irradiation modalities such as provided by a high LET machine are needed for these patients. (orig.)

  7. Radiation therapy for carcinoma of the major salivary glands

    Teshima, T. (Dept. of Radiology, Osaka Univ. Medical School (Japan)); Inoue, Ta. (Dept. of Radiology, Osaka Univ. Medical School (Japan)); Inoue, To. (Dept. of Radiation Oncology, Osaka Univ. Medical School (Japan)); Ikeda, H. (Dept. of Radiation Oncology, Osaka Univ. Medical School (Japan)); Yamazaki, H. (Dept. of Radiation Oncology, Osaka Univ. Medical School (Japan)); Ohtani, M. (Dept. of Radiology, Osaka Univ. Medical School (Japan)); Shimizutani, K. (Dept. of Radiology, Osaka Univ. Medical School (Japan)); Furukawa, S. (Dept. of Radiology, Osaka Univ. Medical School (Japan)); Kozuka, T. (Dept. of Radiology, Osaka Univ. Medical School (Japan)); Murayama, S. (National Inst. of Radiological Science, Chiba (Japan))

    1993-08-01

    From January 1967 through November 1991, a total of 135 patients with carcinoma of the major salivary glands (parotid: 95; submandibular: 39, sublingual: 1) were treated at our department. 40 patients had adenocarcinoma, 29 adenoid cystic carcinoma, 24 mucoepidermoid carcinoma and 16 squamous cell carcinoma. 100 patients were irradiated postoperatively and the remaining 35 were treated with radiation alone. Total radiation doses delivered were 50 Gy for the postoperative group and 50 to 66 Gy for the group receiving only radiation using a [sup 60]Co single portal with or without wedged paired or single electron portal boost. Actuarial five-year survivals after radiation therapy were 55% for the postoperative group and 26% for radiation only group (p=0.0004). The local control rates for the postoperative group were 83% for adenocarcinoma, 81% for adenoid cystic carcinoma, 83% for mucoepidermoid carcinoma and 62% for squamous cell carcinoma. Corresponding figures for the radiation only group were 40% for adenocarcinoma, 38% for adenoid cystic carcinoma and 33% for mucoepidermoid carcinoma. Conventional irradiation techniques continue to play an important role because they offer superior local control for postoperative patients with carcinoma of the major salivary glands. However, the local control rates for the radiation only group were only 30 to 40%, so that new irradiation modalities such as provided by a high LET machine are needed for these patients. (orig.)

  8. Maspin and MCM2 immunoprofiling in salivary gland carcinomas

    Helmy Iman M

    2011-09-01

    Full Text Available Abstract Background The pathogenesis of salivary gland carcinomas is very complex and prognostic markers are difficult to find in these carcinomas of which the different subtypes have varying malignant potential. The study was conducted to examine the cellular distribution of maspin and MCM2 in salivary gland carcinomas and their value to predict lymph node metastasis. Materials and methods Fifty three paraffin blocks of different lesions (15 muco-epidermoid carcinoma, 14 adenoid cystic carcinoma, 3 epi-myoepithelial carcinoma, 5 salivary duct carcinoma, 5 malignant pleomorphic adenoma, 6 polymorphous low grade adenocarcinoma and 5 acinic cell carcinoma were prepared for immunohistochemical staining with maspin and MCM2 antibodies. ANOVA and Pearson correlation tests were used for the statistical analysis of the results. Results All salivary gland carcinomas express maspin and MCM2 with variable cellular localization. There was a significant difference in the expression of each antibody between mucoepidermoid carcinoma, adenoid cystic carcinoma and polymorphous low grade adenocarcinoma. No association was found between examined markers and lymph node metastasis. Conclusions Salivary gland carcinomas express maspin and MCM2 with variable levels and cellular localization, consisting important markers of biological behavior in these tumors. The level of MCM2 expression can be used in the differential diagnosis of adenoid cystic carcinoma and polymorphous low grade adenocarcinoma. Further study with large sample size is recommended to assess their value in prediction of lymph node metastasis.

  9. The prognostic significance of β-catenin, cyclin D1 and PIN1 in minor salivary gland carcinoma: β-catenin predicts overall survival.

    Schneider, Sven; Thurnher, Dietmar; Seemann, Rudolf; Brunner, Markus; Kadletz, Lorenz; Ghanim, Bahil; Aumayr, Klaus; Heiduschka, Gregor; Lill, Claudia

    2016-05-01

    Minor salivary gland carcinoma is a rare and heterogeneous type of cancer. Molecular prognostic and predictive markers are sparse. The aim of this study was to identify new prognostic and predictive markers in minor salivary gland carcinoma. 50 tissue samples of carcinomas of the minor salivary glands (adenoid cystic carcinoma n = 23, mucoepidermoid carcinoma n = 12, adenocarcinoma n = 10, carcinoma ex pleomorphic adenoma n = 2, salivary duct carcinoma n = 1, clear cell carcinoma n = 1, basal cell carcinoma n = 1) were immunohistochemically stained for β-catenin, cyclin D1 and PIN1. Expression patterns were analyzed and correlated to clinical outcome of 37 patients with complete clinical data. High expression of membranous β-catenin was linked to significantly better overall survival in patients with adenoid cystic carcinoma (log rank test, χ (2) = 13.3, p = .00397, Bonferroni corrected p = .024). PIN1 and cyclin D1 did not show any significant correlation to patients' clinical outcome. Expression of β-catenin in adenoid cystic carcinoma of the minor salivary glands significantly correlates with better overall survival. Hence, evaluation of β-catenin might serve as a clinical prognostic marker. PMID:25801951

  10. Continuing occurrence of thyroid carcinoma after irradiation to the neck in infancy and childhood

    To determine whether the occurrence of x-ray-induced thyroid carcinoma has not declined, we examined 100 patients with a history of irradiation to the neck area. Irradiation had been given to tonsils (42 percent), adenoids (10 percent), tonsils and adenoids (7 percent) and thymus (30 percent), for acne (7 percent), and for various other reasons (7 percent). Operation was recommended to 18 of 26 patients with palpable abnormalities and 15 were operated upon; we found seven carcinomas, and eight benign lesions. Five of six carcinomas had invasive characteristics, with or without metastases, five of seven were multifocal, and six of seven had a follicular component. Of seven patients irradiated to both tonsils and adenoids and thus receiving higher radiation exposure, two had carcinoma, suggesting a dose relation. The overall 7 percent prevalence of carcinoma in unselected patients with a history of irradiation to the neck area is higher than expected and implies a continuing important public-health problem, at least in the Chicago area. (auth)

  11. Transoral Robotic Surgery in Treating Patients With Benign or Stage I-IV Head and Neck Cancer

    2014-11-07

    Recurrent Adenoid Cystic Carcinoma of the Oral Cavity; Recurrent Lymphoepithelioma of the Nasopharynx; Recurrent Lymphoepithelioma of the Oropharynx; Recurrent Mucoepidermoid Carcinoma of the Oral Cavity; Recurrent Squamous Cell Carcinoma of the Hypopharynx; Recurrent Squamous Cell Carcinoma of the Larynx; Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity; Recurrent Squamous Cell Carcinoma of the Nasopharynx; Recurrent Squamous Cell Carcinoma of the Oropharynx; Recurrent Verrucous Carcinoma of the Larynx; Recurrent Verrucous Carcinoma of the Oral Cavity; Stage I Adenoid Cystic Carcinoma of the Oral Cavity; Stage I Lymphoepithelioma of the Nasopharynx; Stage I Lymphoepithelioma of the Oropharynx; Stage I Mucoepidermoid Carcinoma of the Oral Cavity; Stage I Squamous Cell Carcinoma of the Hypopharynx; Stage I Squamous Cell Carcinoma of the Larynx; Stage I Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage I Squamous Cell Carcinoma of the Nasopharynx; Stage I Squamous Cell Carcinoma of the Oropharynx; Stage I Verrucous Carcinoma of the Larynx; Stage I Verrucous Carcinoma of the Oral Cavity; Stage II Adenoid Cystic Carcinoma of the Oral Cavity; Stage II Lymphoepithelioma of the Nasopharynx; Stage II Lymphoepithelioma of the Oropharynx; Stage II Mucoepidermoid Carcinoma of the Oral Cavity; Stage II Squamous Cell Carcinoma of the Hypopharynx; Stage II Squamous Cell Carcinoma of the Larynx; Stage II Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage II Squamous Cell Carcinoma of the Nasopharynx; Stage II Squamous Cell Carcinoma of the Oropharynx; Stage II Verrucous Carcinoma of the Larynx; Stage II Verrucous Carcinoma of the Oral Cavity; Stage III Adenoid Cystic Carcinoma of the Oral Cavity; Stage III Lymphoepithelioma of the Nasopharynx; Stage III Lymphoepithelioma of the Oropharynx; Stage III Mucoepidermoid Carcinoma of the Oral Cavity; Stage III Squamous Cell Carcinoma of the Hypopharynx; Stage III Squamous Cell Carcinoma of the Larynx; Stage III Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage III Squamous Cell Carcinoma of the Nasopharynx; Stage III Squamous Cell Carcinoma of the Oropharynx; Stage III Verrucous Carcinoma of the Larynx; Stage III Verrucous Carcinoma of the Oral Cavity; Stage IV Adenoid Cystic Carcinoma of the Oral Cavity; Stage IV Lymphoepithelioma of the Nasopharynx; Stage IV Lymphoepithelioma of the Oropharynx; Stage IV Mucoepidermoid Carcinoma of the Oral Cavity; Stage IV Squamous Cell Carcinoma of the Hypopharynx; Stage IV Squamous Cell Carcinoma of the Larynx; Stage IV Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage IV Squamous Cell Carcinoma of the Nasopharynx; Stage IV Squamous Cell Carcinoma of the Oropharynx; Stage IV Verrucous Carcinoma of the Larynx; Stage IV Verrucous Carcinoma of the Oral Cavity

  12. PALATAL PLEOMORPHIC ADENOMA WITH FLORID SQUAMOUS ME TAPLASIA: A POTENTIAL DIAGNOSTIC PITFALL

    Abdul Hakeem

    2012-07-01

    Full Text Available ABSTRACT: Pleomorphic adenoma is the most common benign tumor occurring in the major and minor salivary glands. We report a case of pleo morphic adenoma with extensive squamous metaplasia in the palate of a 20 year old man. The dimensions of the tumor were 3x2x2cm. More than 75% 0f the epithelial element in the tumor was composed of sheets of squamous cells, with multiple keratin filled cysts. This case illustrates that pleomorphic adenoma with squamous metaplasia presents a potenti al for misinterpretation as mucoepidermoid carcinoma and squamous cell carcinom a. We discuss the various pitfalls and the features that are helpful in distinguishing between these lesions.

  13. Métastases gastro-intestinales du cancer du sein: à propos de 2 cas

    Loubna, Mezouar; Mohamed, El Hfid; Tijani, El Harroudi; Fouzia, Ghadouani; Hanane, Haj Kacem; Zouhour, Bourhaleb; Asmae, Ouabdelmoumen

    2013-01-01

    Le cancer du sein est le cancer le plus fréquent chez la femme, notamment au Maroc, avec un taux de mortalité élevé. Les métastases gastro-intestinales d'un carcinome canalaire du sein sont rares. Leur diagnostic est difficile du fait de la nature non spécifique des symptômes. Nous rapportons deux observations originales de métastases gastroduodénales d'un cancer canalaire infiltrant du sein. Les métastases gastro-intestinales du cancer du sein sont très rares; la présence de symptômes gastro...

  14. Métastase splénique d'un adénocarcinome colique - à propos d'un cas et revue de la littérature

    El M'rabet, Fatima Zahra; Brahmi, Sami Aziz; Rachidi, Siham; Tizniti, Siham; Amaarti, Afaf; Ait Taleb, Khalid; El Mesbahi, Omar

    2011-01-01

    L'atteinte métastatique de la rate est rare et exceptionnellement isolée. En effet, elle survient généralement dans le cadre d'une atteinte multi viscérale. Les cancers les plus pourvoyeurs de métastase splénique sont les mélanomes, les carcinomes de l'ovaire, du sein et du poumon. Dans le cancer colique, l'atteinte métastatique isolée de la rate est rare, dix cas seulement ont été décrits dans la littérature jusque-là. À travers cette revue, nous décrivons un nouveau cas présentant un adénoc...

  15. INTERESTING LESIONS OF BONE MARROW WITH SPECIAL REF ERENCE TO METASTASIS.

    Sreelakshmi

    2012-09-01

    Full Text Available ABSTRACT: BACKGROUND: Bone marrow examination is a commonly used diagnos tic modality in the evaluation of hemato-oncological disorders and in p atients with malignancies of visceral organs to detect metastasis. This study reviews clinical, hematological and pathological data of interesting cases with bone marrow involvement. Out of 490 bone marrow aspirations performed during a period of 4 years, 5 cases show me tastatic carcinomatous deposits which included adenocarcinomas(3, squamous cell carcinom a(1 and neuroendocrine tumour(1, Non-Hodgkins lymphomas(2, storage disorder(2, gran ulomatous lesions(1, gelatinous transformation(1. Fever, generalized weakness, los s of appetite and loss of weight were the main symptoms. Anemia and pancytopenia were the main hematological findings. Dry tap was a significant finding in bone marrow aspiration in ca ses of metastatic cancers.

  16. Neuroendocrine tumor of the skin of head and neck

    Stošić Srboljub

    2005-01-01

    Full Text Available Background. Merkel cell carcinom is a rare neuroendrocine tumor of skin which manifests it self through aggressive growth and early regional metastasis. It develops mainly in older population. Locally, the tumor spreads intracutaneously. Case report. We showed two cases (females of 89 and 70 years old hospitalized within the last two years. The first patient was treated surgically three times. After the surgery, the patient was treated with radio therapy, and died 3 years from the beginning of the treatment. The second patient with this neuroendocrine tumor with the high malignancy potential and huge regional metastasis, was treated surgically, and died a month and a half after the operation. Conclusion. These two cases confirmed the aggressive and recidivant growth of this tumor with the difficult pathologic investigation, and the extremely bad prognosis inspite of the treatment.

  17. [Classification of laryngeal papillomas and papillomatosis (author's transl)].

    Neumann, O G; Klopp, L; Franz, B

    1980-01-01

    The clinical behavior of laryngeal papillomas is discussed by literature and by own 130 cases. Laryngeal papillomatosis is an epithelial proliferative lesion. Without prejudice to viral aetiology it can be interpreted in some cases as a dysplastic epithelial Tumor with the risk of cellular change to carcinoma. A histologic and cytologic classification of laryngeal dysplastic papilloma is described. The basic knowledge has been gained by the experiences in the diagnosis of oral-carcinom, portio-carcinoma and larynx-carcinoma. This classification is used for 48 selected cases of multiple and recurrence laryngeal papillomatosis in which sometimes also elder histological preparations were still available. The results and clinical value are discussed. PMID:7392741

  18. Une tumeur rare et distincte du cancer du sein: le carcinosarcome, à propos de huit cas et revue de la littérature

    Ghanem, Samia; Khoyaali, Siham; Naciri, Sara; Glaoui, Meriem; Mesmoudi, Mohamed; Errihani, Hassan

    2013-01-01

    Le carcinosarcome du sein souvent appelé carcinome métaplasique du sein, est une tumeur maligne rare composée de deux lignées cellulaires distinctes, il est décrit comme un cancer du sein de type canalaire avec un composant de type sarcome. Il représente 0,08-0.2% de toutes les tumeurs malignes du sein. Il s'agit d'une étude rétrospective étalée sur un an, huit cas des carcinosarcomes mammaires ont été colligés à l'Institut national d'oncologie au Maroc durant l'année 2007. La médiane d’âge é...

  19. Rôle des facteurs de transcription E2F2 et ID3 dans la progression tumorale et intérêt du ciblage de l'aminopeptidase N/CD13 dans le traitement du cancer colique humain

    Voegelin, Manon

    2012-01-01

    Une analyse génomique (Comparative Genomic Hybridization) a été réalisée sur une cohorte d'adénomes et de tumeurs coliques et a mis en évidence, parmi d'autres altérations, la délétion de la région 1p36.12 dans 23% des adénomes et 47% des carcinomes. Parmi les 15 gènes ayant une fonction connue retrouvés dans cette zone, le gène codant pour le facteur de transcription E2F2 a été retenu en raison de son implication dans des processus cellulaires clés. Une analyse de Kaplan- Meier a montré que ...

  20. Fibromatose desmode du sein: propos d'un cas et une revue de la literature

    Amourak, Sarah; Alaoui, Fatimazahra Fdili; Jayi, Sofia; Chaara, Hikmat; Melhouf, Moulay Abdelilah

    2015-01-01

    La fibromatose desmode mammaire est une entit rare, mimant sur le plan clinique et chographique un cancer du sein. Seule l'histologie apportera le diagnostic en objectivant une prolifration de cellule fusiforme (fibro et myofibroblastique sans atypies nuclaires), agence en faisceaux, mls des bandes de collagne, sans composante pithliale. Le diagnostic diffrentiel se pose essentiellement avec le carcinome mtaplasique cellules fusiformes. Lvolution est strictement locale, avec un grand pouvoir rcidivant. L'exrse chirurgicale complte avec des marges saines (jusqu 3cm) est le traitement de choix, la radiothrapie reste une option thrapeutique en complment de la chirurgie dans les exrses incompltes et en cas de rcidives multiples. A travers notre cas et une revue de la littrature, nous essayerons de mettre le point sur le diagnostic de cette entit rare et de sa prise en charge puisqu'elle va conditionner le pronostic. PMID:26491531

  1. Hexyl-aminolevulinate mediated photodynamic therapy: how to spare normal urothelium. An in vitro approach

    Vaucher L.

    2006-01-01

    Résumé Objectifs : La thérapie photodynamique a pour but la destruction sélective du tissu néoplasique par interaction de lumière, d'oxygène et d'une substance photosensibilisatrice (la Protoporphyrine IX dans notre étude). Malgré une accumulation sélective du photosensibilisateur dans le tissu tumoral, la thérapie photodynamique du carcinome urothélial de la vessie peut endommager les cellules normales de l'épithélium urinaire. La prévention de ces lésions est importante pour la régénération...

  2. Acetylcysteine Rinse in Reducing Saliva Thickness and Mucositis in Patients With Head and Neck Cancer Undergoing Radiation Therapy

    2016-02-04

    Mucositis; Oral Complications; Recurrent Adenoid Cystic Carcinoma of the Oral Cavity; Recurrent Basal Cell Carcinoma of the Lip; Recurrent Lymphoepithelioma of the Nasopharynx; Recurrent Lymphoepithelioma of the Oropharynx; Recurrent Mucoepidermoid Carcinoma of the Oral Cavity; Recurrent Salivary Gland Cancer; Recurrent Squamous Cell Carcinoma of the Larynx; Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity; Recurrent Squamous Cell Carcinoma of the Nasopharynx; Recurrent Squamous Cell Carcinoma of the Oropharynx; Recurrent Verrucous Carcinoma of the Larynx; Recurrent Verrucous Carcinoma of the Oral Cavity; Stage I Adenoid Cystic Carcinoma of the Oral Cavity; Stage I Basal Cell Carcinoma of the Lip; Stage I Lymphoepithelioma of the Nasopharynx; Stage I Lymphoepithelioma of the Oropharynx; Stage I Mucoepidermoid Carcinoma of the Oral Cavity; Stage I Salivary Gland Cancer; Stage I Squamous Cell Carcinoma of the Larynx; Stage I Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage I Squamous Cell Carcinoma of the Nasopharynx; Stage I Squamous Cell Carcinoma of the Oropharynx; Stage I Verrucous Carcinoma of the Larynx; Stage I Verrucous Carcinoma of the Oral Cavity; Stage II Adenoid Cystic Carcinoma of the Oral Cavity; Stage II Basal Cell Carcinoma of the Lip; Stage II Lymphoepithelioma of the Nasopharynx; Stage II Lymphoepithelioma of the Oropharynx; Stage II Mucoepidermoid Carcinoma of the Oral Cavity; Stage II Salivary Gland Cancer; Stage II Squamous Cell Carcinoma of the Larynx; Stage II Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage II Squamous Cell Carcinoma of the Nasopharynx; Stage II Squamous Cell Carcinoma of the Oropharynx; Stage II Verrucous Carcinoma of the Larynx; Stage II Verrucous Carcinoma of the Oral Cavity; Stage III Adenoid Cystic Carcinoma of the Oral Cavity; Stage III Basal Cell Carcinoma of the Lip; Stage III Lymphoepithelioma of the Nasopharynx; Stage III Lymphoepithelioma of the Oropharynx; Stage III Mucoepidermoid Carcinoma of the Oral Cavity; Stage III Salivary Gland Cancer; Stage III Squamous Cell Carcinoma of the Larynx; Stage III Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage III Squamous Cell Carcinoma of the Nasopharynx; Stage III Squamous Cell Carcinoma of the Oropharynx; Stage III Verrucous Carcinoma of the Larynx; Stage III Verrucous Carcinoma of the Oral Cavity; Stage IV Lymphoepithelioma of the Nasopharynx; Stage IV Squamous Cell Carcinoma of the Nasopharynx; Stage IVA Adenoid Cystic Carcinoma of the Oral Cavity; Stage IVA Basal Cell Carcinoma of the Lip; Stage IVA Lymphoepithelioma of the Oropharynx; Stage IVA Mucoepidermoid Carcinoma of the Oral Cavity; Stage IVA Salivary Gland Cancer; Stage IVA Squamous Cell Carcinoma of the Larynx; Stage IVA Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage IVA Squamous Cell Carcinoma of the Oropharynx; Stage IVA Verrucous Carcinoma of the Larynx; Stage IVA Verrucous Carcinoma of the Oral Cavity; Stage IVB Adenoid Cystic Carcinoma of the Oral Cavity; Stage IVB Basal Cell Carcinoma of the Lip; Stage IVB Lymphoepithelioma of the Oropharynx; Stage IVB Mucoepidermoid Carcinoma of the Oral Cavity; Stage IVB Salivary Gland Cancer; Stage IVB Squamous Cell Carcinoma of the Larynx; Stage IVB Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage IVB Squamous Cell Carcinoma of the Oropharynx; Stage IVB Verrucous Carcinoma of the Larynx; Stage IVB Verrucous Carcinoma of the Oral Cavity; Stage IVC Adenoid Cystic Carcinoma of the Oral Cavity; Stage IVC Basal Cell Carcinoma of the Lip; Stage IVC Lymphoepithelioma of the Oropharynx; Stage IVC Mucoepidermoid Carcinoma of the Oral Cavity; Stage IVC Salivary Gland Cancer; Stage IVC Squamous Cell Carcinoma of the Larynx; Stage IVC Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage IVC Squamous Cell Carcinoma of the Oropharynx; Stage IVC Verrucous Carcinoma of the Larynx; Stage IVC Verrucous Carcinoma of the Oral Cavity; Tongue Cancer

  3. Autoradiographic studies and experiments on partical synchronization of human tumors, especially mammary carcinomas, in vitro and in vivo following xenotransplantation to NU/NU mice

    Human mammary carcinomes were evaluated radiographically in vitro in the native state. Penetration dephts up to 552 μm into the tissue were reached by the incubating medium. The labelling indices for the 3H-thymidine autoradiography lay between 1.5 and 19.3 percent. A correlation of the autoradiographic labelling indices with the findings of a simultaneously performed in vitro sensitivity test against cytostalics could not be proved. There seems to be a relation between the histomorphological tumour image and the proliferation behaviour expressed by the autoradiographic labelling index. Human mammary carcinomes were cultivated as xeno-transplant on thymus-aplastic NU/NU mice in parallel to this investigation. These heterotransplants show a remarkable correlation to the proliferation behaviour of the directly examined human tumours, after an autoradiographic in-vivo-labelling, with index values between 1.5 and 23.8 percent. This parallelism in the biological behaviour represents a further proof for the usefulness of the oncological test model of the NU/NU mouse as a carrier for human cacinomes. The application of this pre-therapeutical test model followed by determination of the synchronization behaviour of three human malignomas after xeno-transplantation onto NU/NU mice. For all three tumous an individual synchronization behaviour could be determined. Therapy attempts followed with cyclophosphonide or ionizing radiation by using the optimal cell-cycle therapy. Therefore an improvement of the therapeutical success by means of pre-therapeutical synchronization of human tumours can be reached in particular cases. (orig./MG)

  4. Lymphangioléiomyomatose pulmonaire de révélation inhabituelle au cours d'une sclérose en plaque

    Jaafoura, Neirouz Ghannouchi; Guigua, Ahmed; Zaghouani, Houneida; Atig, Amira; Bakir, Dajla; Khalifa, Mabrouk; Bahri, Fethi

    2015-01-01

    La lymphangioléiomyomatose pulmonaire est une pathologie rare de la femme jeune, caractérisée par une prolifération de cellules musculaires lisses immatures, aboutissant à la destruction kystique des poumons avec possibilité d’évolution vers l'insuffisance respiratoire chronique. La découverte est souvent fortuite lors de la prise en charge d'une autre pathologie pulmonaire. Son association à une sclérose en plaque n'a jamais été rapportée, de même que l'embolie pulmonaire in situ comme manifestation inaugurale. Nous rapportons l'observation d'une patiente âgée de 39 ans, suivie pour sclérose en plaque depuis 20 ans, chez qui le diagnostic d'une lymphangioléiomyomatose pulmonaire a été posé, à l'occasion d'une broncho-pneumopathie bilatérale avec une embolie pulmonaire associée motivant la réalisation d'un angioscanner thoracique. PMID:26185588

  5. Kyste hydatique du foie rompu dans la veine cave inférieure

    Laalim, Said Ait; Ibn Majdoub Hassani, Karim; Toughai, Imane; Oussaden, Abdelmalek; Kamaoui, Imane; Mazaz, Khalid; Taleb, Khalid Ait

    2011-01-01

    La rupture du kyste hydatique dans la veine cave inférieure est une complication rare et grave des kystes hydatiques hépatique. La manifestation la plus fréquente est l'embolie pulmonaire. L'hémorragie aigue intra-kystique survienne surtout en per-opératoire et elle est d’évolution dramatique. Le diagnostic est basé sur le scanner. Le traitement est chirurgical. Nous rapportons un cas clinique rare chez un patient de 38 ans, opéré en urgence pour un sepsis sur un kyste hydatique du foie comprimant la veine cave inférieur (VCI) avec thrombose partielle de cette dernière. Après évacuation du kyste, une fistulisation spontané per opératoire s'est produite dans la VCI ayant causé le décès du patient. La rupture du kyste hydatique du foie dans la VCI doit toujours être redoutée devant un kyste hydatique des segments postérieurs du foie droit (VII et VIII), comprimant la VCI avec présence en son sein d'une thrombose ou des vésicules filles. Le traitement chirurgical doit être réalisé avec prudence et toujours sous contrôle vasculaire. PMID:22355421

  6. Neurocysticercose révélée par une épilepsie réfractaire: à propos d'une observation

    Bugeme, Marcellin; Mukuku, Olivier

    2015-01-01

    Nous rapportons une observation de neurocysticercose parenchymateuse chez un homme de 38 ans, consommant régulièrement la viande de porc, qui a présenté une épilepsie réfractaire. Le diagnostic de NCC était basé sur la présence de lésions kystiques montrant le scolex sur les images du scanner cérébrale, la présence de signes cliniques évocateurs de NCC (épilepsie faite des crises convulsives focales évoluant vers des crises bilatérales), la réponse clinique au traitement à l'albendazole et le fait que notre patient vit dans une zone reconnue endémique à la cysticercose. Après un traitement fait d'albendazole et de prednisolone, l’évolution est marquée par la disparition complète des crises épileptiques. PMID:26090052

  7. Particle radiotherapy using protons or carbon ions for unresectable locally advanced head and neck cancers with skull base invasion

    To study the oncological outcome of the patients with unresectable locally advanced primary head and neck cancers invading the skull base, treated with particle radiotherapy. Fifty-seven patients with unresectable primary head and neck cancers invading the skull base received proton or carbon ion radiotherapy as definitive treatment at Hyogo Ion Beam Medical Center between 2003 and 2009. Forty-seven patients were treated with proton radiotherapy and 10 patients were treated with carbon ion radiotherapy. A retrospective review was performed with clinical charts and recorded imagings. With a median follow-up of 32 months, the 3-year actual survival and local progression-free rates of all the patients were 61 and 56%, respectively. The 3-year actual survival rates of adenoid cystic carcinoma, squamous cell carcinoma, olfactory neuroblastoma, adenocarcinoma and malignant melanoma were 83, 44, 75, 0 and 38%, respectively. The 3-year actual local control rates of adenoid cystic carcinoma, squamous cell carcinoma, olfactory neuroblastoma, adenocarcinoma and malignant melanoma were 63, 31, 83, 50 and 0%, respectively. Distant metastasis was observed in 13 of 25 patients in adenoid cystic carcinoma, two of 14 patients in squamous cell carcinoma, one of six patients with olfactory neuroblastoma, two of four patients with adenocarcinoma, three of four patients with malignant melanoma and two of three patients with undifferentiated carcinoma. Mucositis and dermatitis were seen as acute toxicities. The most common late toxicity was visual disorder. Grades 2, 3 and 4 visual disorders were observed in seven, five and two patients, respectively. Proton and carbon ion radiotherapy resulted in satisfactory local control in patients with locally advanced unresectable primary head and neck cancers invading the skull base. (author)

  8. Evaluación del adenoidismo en los niños: imagen endoscópica

    Calogero Grillo

    2000-12-01

    Full Text Available El adenoidismo es un síndrome complejo cuya causa principal se identifica generalmente con la hiperplasia de las amígdalas y la nasofaringe, pero abarca también diversos aparatos y estructuras que aún cuando se encuentran lejos de la nasofaringe, se relacionan funcionalmente con ella. Las afecciones locales caracterizadas por obstrucción nasal y rinorrea a menudo purulentas, se asocian con enfermedades de los senos (sinusitis, con afecciones del oído (otalgia, otorrea serosa o serosa-purulenta o ambas cosas, así como hipoacusia, con enfermedades de la laringe (disfonía y afonía, con afecciones de las vías respiratorias inferiores (tos, bronquitis recurrente, con enfermedades de los huesos de la cara (paladar ojival, deficiencia de la oclusión dental, así como con afecciones sistémicas (apnea del sueño, OSAS. La endoscopia de fibra óptica es la prueba de selección para valorar la calidad y la extensión de la hipertrofia de las adenoidesAdenoidism is a complex syndrome whose main cause is generally identified with hyperplasia of the tonsils and nasopharynx, but it also involves diverse systems and structures that even when they are not close to the nasopharynx are functionally related to it. The local affections characterized by usually purulent nasal obstruction and rhinorrea are associated with diseases of the sinuses (sinusitis, with affections of the ear (otalgia, serous or serouspurulent otorrhoea or both, as well as hypoacusia, with larynx diseases (dysphonia and aphonia, with affections of the lower airways (cough, recurrent bronchitis, with face bone diseases (ogival palate, deficiency of dental oclussion, as well as systemic affections (sleep apnea, OSAS. The optic fibre endoscopy is the selection test to asses the quality and extension of adenoids hypertrophy

  9. Benign lymphoepithelial cysts of parotid and submandibular glands in a HIV-positive patient.

    Shivhare, Peeyush; Shankarnarayan, Lata; Jambunath, Usha; Basavaraju, Sowbhagya Malligere

    2015-01-01

    Patients with human immunodeficiency virus (HIV) infection have been reported to have parotid swellings of various types such as diffuse infiltrative lymphocytosis syndrome, parotitis, intraparotid lymphadenopathy, benign lymphoepithelial cyst (BLEC), as well as salivary gland neoplasms such as adenoid cystic carcinoma, Kaposi sarcoma and lymphoma. LECs in the parotid gland are uncommon benign entities with increased incidence associated with HIV infection. We are presenting a case of 28-year-old HIV-positive patient with BLECs in the parotid and submandibular glands. PMID:26097320

  10. The double contrast examination of the colon

    The double contrast method has been modified in order to get a more detailed picture of the mucous membrane of the colon. The method has been employed at Malmoe hospital since 1953. The method and its diagnostic application in cases of adenoids, villiferous tumours, diverticula, Crohn's disease, ulcerating colitis, and deformation of the rectum/sigma junction due to external endometriosis and peritoneal carcinosis are described. The diagnostic values of the double contrast method and colposcopy/biopsy of the colon are compared. The two methods are found to be complementary. (MG)

  11. Coccidiosis due to various species of Eimeria in the stunted and diarrheic native turkey poults: Pathology and morphological characterization of oocysts

    Dezfoulian, O.

    2010-01-01

    Full Text Available Fecal samples of 60 turkey poults that showed chronic progressive symptoms like unthriftiness, loss ofweight, diarrhea were collected from the most rural areas with high rate of turkey population in north andwest part of country for intestinal protozoan parasites. According to the morphological characteristics, likeshape, presence or absence of micropyle, and/or polar granule, the 5 different types of eimerian oocycts were diagnosed in the stool of infected birds, including E. adenoids, E. meleagridis, E. dispersa, Eimeria spp (E. innocua or E. subrotunda and E. meleagrimitis. Various life- cycle stages of Eimeria were identified in the epithelial lining of inflamed intestine of the affected turkey poults.

  12. [Functional characteristics of the central nervous system in children with pharyngeal tonsil lesions].

    Borzov, E V

    2002-01-01

    The analysis of the clinical and neurophysiological evidence obtained upon examination of children with adenoids has shown that pharyngeal tonsil affection is often accompanied by neurological disorders. Perinatal pathology does not influence significantly EEG alterations. Surgical treatment leads to positive changes of both general condition and neurophysiological indices, but part of the children with perinatal encephalopathy worsen because of aggravation of brain problems and appearance of epiphenomena. It is thought necessary to consider perinatal history when planning treatment policy for children with affection of the pharyngeal tonsil. PMID:12056156

  13. Histopathological Assessment and Immunohistochemical Study of Nasopharyngeal Low Grade MALT Lymphoma

    Introduction: MALT lymphoma arises in a variety of body tissues, but most often in the stomach. Though relatively rare, these MALT lymphomas may arise within several sites in the head and neck, and often present diagnostic and therapeutic challenges. Immunohistochemical analysis are helpful in confirming the diagnosis between the MALT-lymphoma and the reactive lymphoid hyperplasia. MALT-type lymphoma demonstrated characteristic negative staining for CD3, CD5 and CD43, positive staining for CD20, and monotypic staining for either kappa or lambda light chain immunoglobulin markers, whereas reactive lymphoid hyperplasia all expressed Band T cell markers. Material and Methods: 41 cases of nasopharyngeal masses were obtained from the files at pathology department, Mansoura Faculty of Medicine through the period from 2002 till 2006. 31 cases were corresponded histomorphologically to low-grade B-cell lymphoma of mucosa associated lymphoid tissue (MALT) type and 10 patients with reactive lymphoid hyperplasia of the adenoid. Hematoxylin-eosin-stained slides were reviewed to confirm the diagnosis. Immunohistochemical studies were performed on formalin-fixed, paraffin-embedded sections using the labeled streptavidin-biotin-peroxidase complex method with DAB as chromogen. The following antibodies were evaluated CD20, CD3, Kappa, lambda and cytokeratin antibodies. Results: All cases of low grade MALT lymphoma show Iymphoepitheliallesion and proliferation of centrocyte like cells. 14 cases (45.1 %) show subepithelial plasma cells. Dutcher bodies were demonstrated in 10 cases (32.2%). Monocytoid B-cells were seen in 12 cases (38.7%). Six (60%) out of the ten cases of adenoids show transmigrating lymphocyte without formation of lymphoepithelial lesion. All cases with MALT-type lymphoma expressed CD20 and not CD3 whereas 10 cases of adenoid, all expressed Band T cell markers. Immunohistochemical staining showed that 31 cases of low grade MALT lymphoma were positive for immunoglobin light chain (kappa or lambda) while 10 cases of adenoid were positive for both kappa and lambda light chain. Conclusion: Immunohistochemical analysis are helpful in confirming the diagnosis between the MALT lymphoma and the reactive lymphoid hyperplasia of the nasopharynx

  14. [A rare case of nasal and buccal obstruction in a child: the antrochoanal polyp of Killian].

    Ayache, S; Chatelain, D; Denimal, F; Deschepper, B; Deramond, H; Benham, T; Strunski, V

    2005-10-01

    Nasal obstruction is a frequent symptom of consultation in paediatric otorhinolaryngology. Usually, adenoid hypertrophy is the cause. Sometimes the examination reveals the presence of polyps in the nose. The antrochoanal polyp of Killian is particularly frequent in childhood. The obstruction is usually unilateral, but the posterior extension of a bulky polyp to the oropharynx can cause a major discomfort, sometimes a respiratory distress. We report the observation of a 10-year-old patient presenting a bulky polyp of Killian, visible in the oropharynx and then discuss the features of this polyp in the literature. PMID:16102955

  15. Prevalence of Otitis Media with Effusion Among Primary School Age-Children and Etiopathogenic Examination

    Sanli, Arif; Tasdemir, Omer; EKEN, MEHMET; Celebi, Ozlem; Yilmaz, Suleyman Hilmi

    2011-01-01

    A prevalence study was carried out in order to look into the etiopathogenic relation of otitis media with effusion (OME) in primary school-age children. The study included ENT examination and a questionnaire that was carried out in 4 randomly selected schools on 1,165 children. 143 of the cases (12.2%) had OME. A significant relation between OME and adenoid vegetation was found (P0.05). As a result, OME is a common disease that can lead to other hard-to-cure health problems and be costly if e...

  16. Minor salivary gland tumors of the upper aerodigestive tract

    This paper compares the outcome of minor salivary gland tumors of the upper aerodigestive tract according to treatment modalities. One hundred fourteen patients with minor salivary gland tumors were treated between 1961 and 1986. The median follow-up was 38 months (24-225 months). There were 35 paranasal sinus tumors (31%), 62 oral cavity tumors (54%), and 17 tumors of other sites (15%). Adenoid cystic carcinoma was the most common histologic type, accounting for 70 lesions (61%), followed by mucoepidermoid carcinoma, n = 28 (25%); adenocarcinoma, 15 (13%); and malignant mixed tumor, n = 1 (1%)

  17. An Evaluation on the Importance of Phosphotungstic Acid Haematoxyiin (PTAH Staining in Differential Diagnosis of Salivary Gland Neoplasms

    E Yazdi

    2003-02-01

    Full Text Available The differential diagnosis between pleomorphic adenoma, the most common salivary gland neoplasm, microscopically, and two other common salivary gland neoplasms, meaning adenoid cystic carcinoma and mucoepidermoid carcinoma, is difficut.The purpose of this study was to determine the differences between pleomorphic adenoma, adenoid cystic carcinoma and mucoepidermoid carcinoma regarding the staining intensity with PTAH and H&E and also to investigate the relationship between staining intensity with PTAH and malignancy grade in mucoepidermoid carcinoma. 72 paraffin embeded samples including 24 pleomorphic adenoma, 24 adenoid cystic carcinoma and 24 mucoepidermoid carcinoma were selected and stained with PTAH. The staining intensity in total, in nucleus and cytoplasm of tumoral cells were evaluated and compared with H&E staining, statistically. The results were analyzed by Kruskal-Wallis, and Wilcoxon signed ranks tests (P<0.05.The logistic model was presented to predict the degree of malignancies through the assessment of nucleus and cytoplasm staining intensity in tumoral cells, and the patient's age. In this study, a statistically significant relationship was observed between staining intensity by PTAH and H& E in nucleus of tumoral cells in pleomorphic adenoma. Moreover, statistically significant relation between staining intensity by PTAH and H & E in cytoplasm of tumoral cells in adenoid cystic carcinoma was found. But there was no relation in other cases. On the other hand, a statistically significant relation between intensity of staining in total, in nucleus and cytoplasm of tumoral cells and the type of tumor was found. No relation was obtained between malignancy grade of mucoepidermoid carcinoma and staining intensity in total, in nucleus and cytoplasm of tumoral cells. The presented logistic model indicated a direct relation between tumor malignancy with patient's age and staining intensity in nucleus of tumoral cells, but a reverse relation was found between cytoplasm staining intensity in tumoral cells and tumor malignancy.Our findings show that PTAH and H & E staining methods, lead to similar results, however, PTAH staining is a reliable method in differential diagnosis of such salivary gland tumors.

  18. Uncommon breast lesions. Radiologic and pathologic findings

    To illustrate the radiologic findings in several uncommon breast and infrequent diseases that present with unusual mammographic images. We reviewed the mammograms performed in our department between 1998 and 1995, selecting 16 patients (12 women and 4 men). Nine patients had benign breast lesions (adenomyoepithelioma, epidermal cyst, adenoid cystic carcinoma, myofibroblastoma, multiple hamartomas, intra cystic papillomas, lipoma, idiopathic granulomatous mastitis and fat necrosis) and 7 patients presented malignant breast diseases (malignant fibrous histiocytoma, intra cystic carcinoma, primary lymphoma of the breast, liposarcoma and metastasis). We present a review of the radiologic and pathologic findings in several uncommon breast diseases. (Author) 14 refs

  19. The results of combined therapy malignant neoplasms of maxillary sinus at Oncology Center in Poznan

    Between 1985-1989 22 patients with malignant neoplasma maxillary sinus have been treated. At the first stage the surgical resection of maxilla was performed. Most of the patients (77%) had histopathological diagnosis of carcinoma planoepitheliale, 13% carcinoma solidum and 4% carcinoma adenoides cysticum. All patients had adjuvant therapy by Co-60 irradiation. Single fraction dose of 2 Gy/T 5 times a week up to total dose of 60-70 Gy/T has been applied. In the follow-up period of minimum 36 months the free-symptoms survival rate of 18%. (author)

  20. Osteopontin expression in salivary gland carcinomas

    Bjrndal, Kristine; Larsen, Stine R; Godballe, Christian; Krogdahl, Annelise

    2011-01-01

    J Oral Pathol Med (2010) Background:? In several cancer types, osteopontin (OPN) expression has been correlated with tumor progression and prognosis. Two earlier studies have examined OPN expression in salivary gland carcinomas with contradictory results. Methods:? One hundred and seventy......:? Osteopontin was expressed in all salivary gland carcinomas. Adenoid cystic carcinomas had the highest mean sum score (7.3) and a significantly higher proportion of carcinomas with high OPN sum score than both mucoepidermoid carcinoma and acinic cell carcinoma. Correlation of OPN expression with known...

  1. Situational Awareness: Regulation of the Myb Transcription Factor in Differentiation, the Cell Cycle and Oncogenesis

    George, Olivia L.; Ness, Scott A., E-mail: sness@salud.unm.edu [Department of Internal Medicine, Section of Molecular Medicine, University of New Mexico Health Sciences Center, MSC07 4025-CRF 121, 1 University of New Mexico, Albuquerque, NM 87131 (United States)

    2014-10-02

    This review summarizes the mechanisms that control the activity of the c-Myb transcription factor in normal cells and tumors, and discusses how c-Myb plays a role in the regulation of the cell cycle. Oncogenic versions of c-Myb contribute to the development of leukemias and solid tumors such as adenoid cystic carcinoma, breast cancer and colon cancer. The activity and specificity of the c-Myb protein seems to be controlled through changes in protein-protein interactions, so understanding how it is regulated could lead to the development of novel therapeutic strategies.

  2. Targeted inhibition of cell-surface serine protease Hepsin blocks prostate cancer bone metastasis

    Tang, Xi; Mahajan, Sumit S; Nguyen, Liem T.; Béliveau, François; LeDuc, Richard; Simon, Julian A; Vasioukhin, Valeri

    2014-01-01

    The development of effective therapies inhibiting prostate cancer progression and metastasis may substantially impact prostate cancer mortality and potentially reduce the rates of invasive treatments by enhancing the safety of active surveillance strategies. Hepsin (HPN) is a cell surface serine protease amplified in a subset of human sarcomas (7.2%), as well as in ovarian (10%), lung adeno (5.4%), lung squamous cell (4.5%), adenoid cystic (5%), breast (2.6%), uterine (1.7%) and colon (1.4%) ...

  3. The first French randomized prospective study of the economic and medical benefit of carbon ion radiotherapy; Premiere etude francaise prospective randomisee de l'interet medical et economique de la radiotherapie par ions carbone

    Pommier, P. [Centre Leon-Berard, Lyon (France); Patin, S.; Vogin, G.; Hu, Y. [GCS-etoile, Lyon (France); Buron van de Voorde, C. [Hospices civils de Lyon (France); Baron, M.H. [CHUde Besancon (France); Lievre, M. [Universite Claude-Bernard, Lyon (France); Balosso, J. [Universite Joseph-Fourier, Grenoble (France)

    2011-10-15

    Carbon ion therapy is an innovative radiotherapy modality for non-operable radio-resistant or resected cancers. Its efficiency is due to improved ballistic accuracy and biological efficiency. The authors present the first phase III study of carbon ion therapy in France. This technique concerns some sarcomas and adenoid cystic carcinomas of head and neck. The authors indicate the possible treatment procedures (doses, sessions) for the different types of cancers, and how the study is to be performed (number of patients, randomization, and multicentre approach). Short communication

  4. The results of combined therapy malignant neoplasms of maxillary sinus at Oncology Center in Poznan; Ocena wynikow leczenia skojarzonego chorych na nowotwory zlosliwe zatoki szczekowej w materiale Wielkopolskiego Centrum Onkologii

    Adamiak, E.; Cerkaska-Gluszak, B.; Gorny, A. [Wielkopolskie Centrum Onkologii im. M. Sklodowskiej-Curie, Poznan, (Poland)

    1994-12-31

    Between 1985-1989 22 patients with malignant neoplasma maxillary sinus have been treated. At the first stage the surgical resection of maxilla was performed. Most of the patients (77%) had histopathological diagnosis of carcinoma planoepitheliale, 13% carcinoma solidum and 4% carcinoma adenoides cysticum. All patients had adjuvant therapy by Co-60 irradiation. Single fraction dose of 2 Gy/T 5 times a week up to total dose of 60-70 Gy/T has been applied. In the follow-up period of minimum 36 months the free-symptoms survival rate of 18%. (author) 5 refs, 3 tabs, 1 fig

  5. Immunophenotypic analysis of human mast cells by flow cytometry.

    Escribano, L; Navalón, R; Núñez, R; Díaz Agustín, B; Bravo, P

    2001-05-01

    The immunophenotypic identification and enumeration of human bone marrow mast cells represents a clear demonstration of the utility of flow cytometry for rare-event analysis. The basic approach can be applied to a variety of specimens, including bone marrow, peripheral blood, ascitic fluid, and lymphoid tissue such as adenoids. Special emphasis is placed on markers with potential utility for distinguishing between normal, reactive, and pathological mast cells. From the clinical aspect, immunophenotypic analysis of mast cells may have great utility in supporting the diagnosis of tissue involvement in mastocytosis. PMID:18770717

  6. Effectiveness of circumoral muscle exercises in the developing dentofacial morphology in adenotonsillectomized children: An ultrasonographic evaluation

    Das U

    2009-06-01

    Full Text Available Alterations in the functions of the facial muscle can establish changes in facial skeleton and in the development of occlusion. The effect of mouth breathing on the facial morphology is probably greatest during the growth period. Removal of nasal obstruction, adenoids, and tonsils have not given beneficial results in the reversion of the habit unless intercepted with various muscle exercises. Hence, this study was conducted to ultrasonographically evaluate the effectiveness of circumoral muscle exercises in the developing dentofacial morphology in adenotonsillectomized children.

  7. The relation between childhood obesity and adenotonsillar hypertrophy.

    Daar, Ghaniya; Sarı, Kamran; Gencer, Zeliha Kapusuz; Ede, Hüseyin; Aydın, Reha; Saydam, Levent

    2016-02-01

    Childhood obesity is a common and significant public health problem all over the world. As a well-known fact obese children have an increased risk of obesity-associated comorbidities, including obstructive sleep apnea, diabetes, and cardiovascular disorders at an earlier age compared to their normal weight peers. They also have an increased risk of poor self-esteem, greater body dissatisfaction, and increased peer teasing that lead to a lower health-related quality of life. While the presence of adenoid hypertrophy and increased rate of obstructive sleep apnea frequently co-exists in majority of cases. We have limited knowledge about the effect of adenotonsillar hypertrophy on development of childhood obesity. In this study, we aimed to investigate the association between obesity, presence of adenotonsillar hypertrophy and the quality of life parameters in obese children as measured by the OSA-18 quality of life questionnaire. Fifty obese children aged between 3 and 18 years and 50 age- and gender-matched otherwise children were enrolled to the study. All subjects were routinely examined by the otolaryngologist before enrollment. The size of adenoid hypertrophy was measured using lateral cephalometric radiographs. The tonsils were also graded using the schema recommended by Brodsky et al. We used OSA-18 questionnaires to evaluate the subjects' quality of life issues. We found, 34 % of obese group had tonsillar hypertrophy while the rate was 6 % in control group. Similarly 16 % of obese group had tonsillar hypertrophy compared to only 4 % in non-obese group. It was also noted that total OSA-18 scores of obese group were significantly higher than those of non-obese group. In subgroup analysis of obese group, total OSA-18 score of obese subjects with either adenoid and/or tonsillar hypertrophy was significantly higher than that of obese subjects without adenoid or tonsillar hypertrophy. As the related literature suggests that the impact of adenotonsillar size on OSA symptoms is prominent especially in children under 7 years of age, but its impact on the development of childhood obesity is still controversial. Our results revealed a possible relation between adenotonsillar hypertrophy and obesity rates. Further studies on larger populations should be planned to better define the real impact of adenotonsillar hypertrophy in obese children. PMID:25876003

  8. Imaging of nasopharyngeal cysts and bursae

    Ben Salem, D.; Ricolfi, Frederic [CHU DIJON, Service de Neuroradiologie et de Radiologie des Urgences, Dijon, Cedex (France); Duvillard, Christian; Ballester, Michel [CHU DIJON, Service d' ORL, Dijon, Cedex (France); Assous, Dorothee [CHU DIJON, Service d' Anatomie et de Cytologie Pathologiques Faculte de Medecine, Dijon, Cedex (France); Krause, Denis [CHU DIJON, Service d' Imagerie Diagnostique et Interventionnelle, Dijon, Cedex (France)

    2006-10-15

    Cysts and bursae of the nasopharynx are uncommon and seldom symptomatic when compared with malignant tumors of this region. However, it is noteworthy that in the presence of symptoms, a good knowledge of their radiological appearance is useful to establish the correct diagnosis. Cysts of Rathke's pouch, pharyngeal bursa of Luschka, Tornwaldt's cysts, retentional cysts of the seromucinous glands, oncocytic cysts, intra-adenoid cysts, branchial cysts, prevertebral or retropharyngeal abscess and pseudocysts of the nasopharynx will be discussed in this paper. (orig.)

  9. Histopatologa de cirrosis y hepatocarcinoma por Virus B

    Jos A. Ramrez-Corrales

    2008-11-01

    Full Text Available Cirrosis por virus B: Se puede detectar en biopsia el antgeno de superficie con tincin de orcena (hepatocitos esmerilados y por inmunohistoqumica (antgeno de superficie y anticore. Estadios de evolucin: a temprano o incipiente: ndulos no definidos, mucha fibrosis y alteracin arquitectural; b establecido: ndulos rodeados completamente de bandas fibroticas. estadio histolgico: a activo: necrosis e inflamacin importante, colestasis; b Inactivo: poca necrosis o inflamacin, hepatocarcinoma: (tipos: trabecular, clulas claras, adenoide, slido, escirroso. La immunohistoquimica ayuda a definir el tipo usando los antgenos hepatocelulares, antgeno carcinoembrinico, citoqueratinas, cromogranina y sinaptofisina.

  10. Collision tumor of the frontal sinus: evidence of prior intrasinus instillation of thorotrast

    Carcinoma of the frontal sinus is relatively rare. We describe a case of two independent carcinomas, squamous cell and adenoid cystic, in the right frontal sinus region of a patient who received sinus irrigation with an unidentified, substance 30 years previously. Radioautography performed on sections of the tumor tissue revealed linear tracks of the type produced by thorium decay, strongly suggesting that the substance was thorotrast. In addition to being the first description of a ''collision tumor'' of the frontal sinus, the case would represent the first reported instance of frontal sinus carcinoma following intrasinus instillation of thorotrast

  11. WholeBbody Positron-Emission-Tomography (WB-PET) in oncology; Ganzkoerper-Positronen-Emissions-Tomographie (GK-PET) in der Onkologie

    Feine, U. [Nuklearmedizinische Abt., Tuebingen Univ. (Germany); Lietzenmayer, R. [Nuklearmedizinische Abt., Tuebingen Univ. (Germany); Mueller-Schauenburg, W. [Nuklearmedizinische Abt., Tuebingen Univ. (Germany); Geiger, L. [Nuklearmedizinische Abt., Tuebingen Univ. (Germany); Hanke, J.P. [Nuklearmedizinische Abt., Tuebingen Univ. (Germany); Weisser, G. [Nuklearmedizinische Abt., Tuebingen Univ. (Germany); Woehrle, H. [Nuklearmedizinische Abt., Tuebingen Univ. (Germany)

    1996-02-01

    The new generation of high sensitive PET-Scanners with an FOV of about 15 cm allows to recognize with high sensitivity and good spezificity malign tumors and their metastases with 18F-FDG in a Whole-Body-Scan in 35 to 50 min scan time. 357 FDG-WB-PET-Scans have been performed in Tuebingen during 1 1/2 years since January 1994 in tumor patients and have been compared and evaluated to the results of other imaging methods performed in the same time together with clinics and in follow-up. In 4 groups of tumors - Melanoma - malign Lymphoma - Breast Cancer - Thyroid Cancer - and a fifth group of 24 various types of malign tumors we found a sensitivity of 88%, a specificity of 80% and an accuracy of 90%. Foci smaller than 6-8 mm diametre - mostly lung metastases or lymphomas - and also tumors of low malignancy such as 131l-trapping Tyroid Carcinomas and Ganglioneuroblastomas have been found false negative. Flase positive we found inflammated lymph nodes, abscesses and also benign thyroid adenomas. This high sensitivity makes 18F-FDG-WB-PET an important method for tumor searching and diagnosis of tumor spreading, esp. for primary and secondary staging in the future, but also as the unique imaging method which allows determination of resting tumor vitality after therapy. Further multi-center studies will be necessary before this method can be introduced to routine, that also is limited by the high costs of the procedure. (orig.) [Deutsch] Die neue Generation der hochaufloesenden PET-Scanner mit einer axialen Feldbreite von 15 cm ermoeglicht es, mit hoher Sensitivitaet und guter Spezifitaet maligne Tumoren und ihre Metastasen mit 18F-Fluordeoxyglukose in einem Ganzkoerper-Scan mit 35-50 min Scan-Zeit zu erkennen. 357 FDG-GK-PET Scans wurden in 1 1/2 Jahren ab Januar 1994 in Tuebingen bei Tumor-Patienten durchgefuehrt und mit gleichzeitig erstellten anderen bildgebenden Verfahren zusammen mit der Klinik und im Follow Up ausgewertet. Bei den vier Tumorgruppen Melanom - Malignes Lymphom - Mamma-Carcinom - Schilddruesen-Carcinom und einer fuenften Gruppe, in der 24 verschiedene maligne Tumoren untersucht worden waren, ergaben sich eine Sensitivitaet von 88%, eine Spezifitaet von 80% und eine Treffsicherheit von 90%. Falsch negativ waren Herde <6-8 mm im Durchmesser, meist Lungenmetastasen oder Lymphome, sowie niedrig maligne Tumoren wie 131J-speichernde Schilddruesen-Carcinome und auch Ganglioneuroblastome. Falsch positiv ergaben sich entzuendliche Lymphknoten, Abszesse, aber auch benigne Schilddruesenadenome. Bei der gefundenen hohen Sensitivitaet duerfte 18FDG-GK-PET in Zukunft ein wertvolles Verfahren zur Tumorsuche und Tumorausbreitungsdiagnostik sowie fuer das primaere und sekundaere Staging sein, aber auch zur Bestimmung der Restaktivitaet in Tumoren nach Therapie als einziges bildgebendes Verfahren eine Aussage ermoeglichen. Weitere Multizenterstudien sind notwendig, bevor das Verfahren in die Routine eingefuehrt werden kann, dem allerdings bisher auch die hohen Kosten noch entgegenstehen. (orig.)

  12. Mucocle appendiculaire : propos dun cas observ Lubumbashi

    KIPILI A

    2013-01-01

    Full Text Available RESUMELa mucocle appendiculaire est une entit pathologique rare, mais potentiellement dangereuse ; elle se prsente sous diffrentes formes cliniques. Nous rapportons ici un cas d'une patiente ge de 49 ans sans antcdents chirurgicaux chez qui nous avons dcouvert dune faon fortuite cette affection. La clinique tait celle dun syndrome appendiculaire aigu patent et elle rvlait une masse dans la fosse iliaque droite. Les examens de laboratoire ont montr une hyperleucocytose et une vitesse de sdimentation augmente. L'chographie a dmontr une masse kystique pricaecal. La patiente a subi une appendicectomie avec ccectomie partielle et la pice opratoire appendiculaire mesurait 153 mm de longueur et 64 mm de diamtre. Lanalyse anatomopathologique de celle-ci a confirm le diagnostic de mucocle appendiculaire sans cellules de malignit. Les suites opratoires ont t simples et la patiente est sortie au cinquime jour postopratoire. Mots-cls : Mucocle appendiculaire Tumeur muco-scrtant appendiculaire ; Appendicite ; LubumbashiSummary The appendiceal mucocele is a rare, but potentially dangerous pathological entity which presents in various clinical forms. We report here a case of a 49-year-old female patient without surgical history to whom we fortuitously discovered this affection. She came with clinical signs of an acute appendicitis and revealed a mass in the right iliac fossa. The examinations of laboratory showed an increase of white cells and of erythrocytes sedimentation rate. The ultrasound revealed a fluid pericaecal mass. The patient underwent an appendectomy with partial ccectomy. The removed appendix measured 153 mm in length over 64 mm. The pathology confirmed the diagnosis and ruled out a malignant process. The postoperative went well and the patient was discharged on the fifth post-operative day.

  13. Tumor scintigram, 2

    In various cases of malignant tumors, especially those of lung cancer and liver cancer, scans were made with 57Co-bleomycin(BLM), and its diagnostic significance was evaluated. Tumors were visualized with 57Co-BLM in 22 of the 26 cases of lung cancer (84.6%). Concentrations of the RI were noted in all of the cases of squamous epithelium cancer, adenoid cancer and cellule-type undifferentiated cancer. The smallest tumor that could be detected was a 2 x 2 cm adenoid cancer. Tumors were imaged in 19 of the 27 cases of liver cancer (70.4%). This detection rate was increased by a combination of 57Co-BLM and 198Au-colloid scanning. The authors believe that 57Co-BLM will help to establish the diagnosis of lung cancer or liver cancer. Tumors were also imaged in 6 of the 15 cases of breast cancer, but no distinct concentration was noted in the 7 cases of thyroid cancer. (Ueda, J.)

  14. Patterns of nodal relapse after surgery and postoperative radiation therapy for carcinomas of the major and minor salivary glands: What is the role of elective neck irradiation?

    Purpose: To evaluate the incidence of nodal relapses from carcinomas of the salivary glands among patients with clinically negative necks in an attempt to determine the potential utility of elective neck irradiation (ENI). Methods and Materials: Between 1960 and 2004, 251 patients with clinically N0 carcinomas of the salivary glands were treated with surgery and postoperative radiation therapy. None of the patients had undergone previous neck dissection. Histology was: adenoid cystic (84 patients), mucoepidermoid (60 patients), adenocarcinoma (58 patients), acinic cell (21 patients), undifferentiated (11 patients), carcinoma ex pleomorphic adenoma (7 patients), squamous cell (7 patients), and salivary duct carcinoma (3 patients); 131 patients (52%) had ENI. Median follow-up was 62 months (range, 3-267 months). Results: The 5- and 10-year actuarial estimates of nodal relapse were 11% and 13%, respectively. The 10-year actuarial rates of nodal failure were 7%, 5%, 12%, and 16%, for patients with T1, T2, T3, and T4 disease, respectively (p = 0.11). The use of ENI reduced the 10-year nodal failure rate from 26% to 0% (p = 0.0001). The highest crude rates of nodal relapse among those treated without ENI were found in patients with squamous cell carcinoma (67%), undifferentiated carcinoma (50%), adenocarcinoma (34%), and mucoepidermoid carcinoma (29%). There were no nodal failures observed among patients with adenoid cystic or acinic cell histology. Conclusion: ENI effectively prevents nodal relapses and should be used for select patients at high risk for regional failure

  15. Clinical investigation of malignant parotid tumors

    We reviewed 55 cases of previously untreated malignant tumors arising in the parotid gland treated between Jan 1989 and May 2008. Histopathologically, we observed 13 tumor types, the most frequent histological type being mucoepidermoid carcinoma (12), followed by adenoid cystic carcinoma (11). According to clinical stage, 5 subjects were classified as T1, 18 as T2, 10 as T3, and 22 as T4. N+ cases numbered 7, and were staged as N2. Six had distant metastasis (5 lung and 1 axillary). Nineteen exhibited facial nerve palsy before treatment. Among major therapies, surgery was conducted in 50 subjects, radiation therapy in 3, and chemotherapy, and percutaneous ethanol injection therapy in each. Overall five-year survival determined using the Kaplan-Meier method was 73%. Among major histopathological types, five-year survival was 33% for undifferentiated carcinoma, 40% for adenocarcinoma, 62% for mucoepidermoid carcinoma, 67% for carcinoma in pleomorphic adenoma, and 100% for adenoid cystic carcinoma and acinic cell carcinoma. By T classification, five-year survival was 100% for T1, 88% for T2, 90% for T3, and 44% for T4. Five-year survival was 36% for those exhibiting facial nerve palsy and 94% for non palsy. Factors influencing poor outcome were T4 (p=0.001) and facial nerve palsy (p=0.001). (author)

  16. CT findings of malignant nasal cavity tumors

    To evaluate the CT findings of malignant nasal cavity tumors. Retrospective analysis was performed on 20 patients with pathologically-proven malignant nasal cavity tumors. Using CT, we analysed their location, extent of bone destruction and of involvement of adjacent structures, and enhancing pattern. A total of 20 cases included nine squamous cell carcinomas, three olfactory neuroblastomas, three lymphomas, two polymorphic reticulosis, one adenoid cystic carcinoma, one undifferentiated carcinoma and one metastasis from renal cell carcinoma. All cases except one adenoid cystic carcinoma and one squamous cell carcinoma revealed bone destruction or erosion. Aggressive bone destruction and irregular enhancement were seen in eight cases of squamous cell carcinoma, seven cases of which showed involvement of the adjacent paranasal sinuses, nasopharynx, and orbit. Olfactory neuroblastomas were centered in the superior nasal cavity and the adjacent ethmoid sinus, and erosion or destruction of the cribriform plate had occurred. Lymphomas showed bilateral involvement, with uniform contrast enhancement. Polymorphic reticuloses showed perforation or erosion of the nasal septum, with bilateral involvement of the nasal cavity. The location, presence of bone destruction, involvement of adjacent structures, and enhancement pattern of tumor on CT can be helpful for the differential diagnosis of malignant nasal cavity tumors

  17. Assessment of Characteristics of Basal Cell Carcinoma and its Pathological Variations among Patients Referred to Boo Ali Sina Hospital of Sari/Iran from 1993-2006

    2008-01-01

    Full Text Available Basal Cell Carcinoma (BCC as a type of skin cancer is one of complications of overexposure to sunlight Ultraviolet (UV radiation. Although radiotherapy and chronic arsenic poisoning are predisposing factors for BCC, the role of sunburn is essential. The aim of this study was to determine the sex-age specific incidence and prevalence of the main pathological types of BCC. This retrospective study was performed based on histopathology report cards of pathology ward of Boo-Ali Sina Hospital of Mazandaran University of Medical Sciences in Sari/Iran between 1993-2006. We studied the BCC pathology reports extracted from all histopathology report cards of pathology ward archive of the hospital. Two hundred and thirty seven cases (with mean age of 57.7 years were studied. One hundred twenty of them were men. Out of 237 BCC samples, 208 (87.76% were solid with maximum number of cases, 14 (5.91% adenoid, 12 (5.06% keratotic and 3 (1.27% were cystic. The mean ages of solid, adenoid, keratotic and cystic cases were 51.7, 53.6, 62.7 and 49.4, respectively. Based on results of the study, considering high incidence of BCC in women older than 50 years, biopsy from suspected lesions to rule out BCC is recommended.

  18. Acantholytic squamous cell carcinoma: pathological study of nine cases with review of literature.

    Sajin, Maria; Hodorogea Pris?caru, Alina; Luchian, Mihaela Cristina; P?tra?cu, Oana Maria; Dumitru, Adrian; Costache, Diana; Dumitrescu, Doina; Vrnceanu, Daniela; Voinea, Liliana Mary; Simionescu, Olga; Costache, Mariana

    2014-01-01

    Squamous cell carcinoma (SCC) is classified in many subtypes or forms; one of them is the acantholytic squamous cell carcinoma, also called pseudoglandular, adenoid, epithelioma dyskeratoticum segregans, or adenoacanthoma. Researching and analyzing nine cases of acantholytic squamous cell carcinoma, we intend to verify if the data provided by the cases studied can be validated by the scientific literature. All the cases presented lesions found on the head and neck skin, with two exceptions - one on the larynx and the other one on the tonsil, all of them ulcerated lesions. In two cases, the tumors developed on the skin, in preneoplasic lesions (actinic keratosis). The tumors had dimensions between 4/3/4 mm and 100/90/36 mm. During one year, two of the cases studied presented multiple recurrences. We also found two cases of metatypical carcinoma accompanied the acantholytic variant of squamous cell carcinoma. None of the analyzed cases presented distant metastasis. The histopathological criteria for selection were: keratinised squamous tumor cell type, adenoid structures with round spaces with a defined wall of at least one cell width, spaces with isolated or grouped dyskeratotic acantholytic cells. PMID:24969975

  19. Histopatologa de cirrosis y hepatocarcinoma por Virus B / Cirrhosis and hepatocarcinoma in HBV

    Jos A., Ramrez-Corrales.

    2008-11-01

    Full Text Available Cirrosis por virus B: Se puede detectar en biopsia el antgeno de superficie con tincin de orcena (hepatocitos esmerilados) y por inmunohistoqumica (antgeno de superficie y anticore). Estadios de evolucin: a) temprano o incipiente: ndulos no definidos, mucha fibrosis y alteracin arquitectural [...] ; b) establecido: ndulos rodeados completamente de bandas fibroticas. estadio histolgico: a) activo: necrosis e inflamacin importante, colestasis; b) Inactivo: poca necrosis o inflamacin, hepatocarcinoma: (tipos): trabecular, clulas claras, adenoide, slido, escirroso. La immunohistoquimica ayuda a definir el tipo usando los antgenos hepatocelulares, antgeno carcinoembrinico, citoqueratinas, cromogranina y sinaptofisina. Abstract in english HBV cirrosis: The surface antigen can be detected by biopsy, orcein tinctions (emery hepatocytes), and immunohistochemistry (surface antigen and anticore). Evolution Stages: a) Early or incipient (non-defined nodes, a lot of fibrosis and architectural alteration); b) established (nods completely sur [...] rounded by fibrotic bands). Histological Stages: a) active (main necrosis and inflammation; and cholestasis); b) inactive (little necrosisor inflammation). Types of Hepatocarcinomas: trabecular-clear cells- adenoid-solid-scirrhous. The immunohistochemistry helps to define the type using the hepatocellular antigens, carcinoembryonic antigen, cytokeratin, chromogranins and synapto-physins.

  20. Intravoxel incoherent motion MRI: emerging applications for nasopharyngeal carcinoma at the primary site

    We compared pure molecular diffusion (D), perfusion-related diffusion (D*), perfusion fraction (f) and apparent diffusion coefficient (ADC) based on intravoxel incoherent motion (IVIM) theory in patients with nasopharyngeal carcinoma (NPC). Sixty-five consecutive patients (48 men) with suspected NPC were examined using a 3.0-T MR system. Diffusion-weighted imaging (DWI) was performed with 13 b values (range, 0-800 s/mm2). We regarded the result of endoscopy and biopsy as the gold standard for detection. D, D* and f were compared between patients with primary NPC and enlarged adenoids. IVIM DWI was successful in 37 of 40 NPC and 23 of 25 enlarged adenoids cases. D (P = 0.001) and f (P 0.05). The area under the ROC curve (AUC) for D was 0.849 and was significantly larger than that for ADC (P < 0.05). IVIM DWI is a feasible technique for investigating primary NPC. D was significantly decreased in primary NPC, and increased D* reflected increased blood vessel generation and parenchymal perfusion in primary NPC. (orig.)

  1. Radiotherapy for primary carcinoma of the trachea

    Between 1940 and 1985, 24 cases of primary carcinoma of the trachea were registered at the London Regional Cancer Centre. The most common presenting symptoms were hoarseness, haemoptysis and cough. Twenty patients had epidermoid carcinoma and four had adenoid cystic carcinoma. Because of different clinical behaviours, the two histologies were separately analyzed. Of the 20 patients with epidermoid carcinoma, 19 received radiotherapy as primary treatment and one patient did not receive radiotherapy because of advanced disease. Radiation doses ranged from 4000 to 600 cGy and most patients had megavoltage irradiation. Treatment result was disappointing. Only one patient remained disease-free at 15-month follow-up and all other patients had persistent or recurrent tracheal tumour. Medain survival for all 20 patients was 5 months (range 1 to 19 monthes). Of the four patients with adenoid cystic carcinoma, two had primary surgery and postoperative radiotherapy and two had primary radiotherapy. Two patients died of disease, at 5 months and 8 years from diagnosis. Two surviving patients had 15 months follow-up: one had persistent disease and the other was free from recurrence. In this study, radiotherapy within the range of doses given was found to be an ineffective primary treatment for tracheal carcinoma. (author). 15 refs.; 3 tabs

  2. L-lysine in Treating Oral Mucositis in Patients Undergoing Radiation Therapy With or Without Chemotherapy For Head and Neck Cancer

    2013-05-15

    Mucositis; Oral Complications of Chemotherapy; Oral Complications of Radiation Therapy; Recurrent Adenoid Cystic Carcinoma of the Oral Cavity; Recurrent Basal Cell Carcinoma of the Lip; Recurrent Lymphoepithelioma of the Nasopharynx; Recurrent Lymphoepithelioma of the Oropharynx; Recurrent Mucoepidermoid Carcinoma of the Oral Cavity; Recurrent Salivary Gland Cancer; Recurrent Squamous Cell Carcinoma of the Hypopharynx; Recurrent Squamous Cell Carcinoma of the Larynx; Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity; Recurrent Squamous Cell Carcinoma of the Nasopharynx; Recurrent Squamous Cell Carcinoma of the Oropharynx; Recurrent Verrucous Carcinoma of the Larynx; Recurrent Verrucous Carcinoma of the Oral Cavity; Stage I Adenoid Cystic Carcinoma of the Oral Cavity; Stage I Basal Cell Carcinoma of the Lip; Stage I Lymphoepithelioma of the Nasopharynx; Stage I Lymphoepithelioma of the Oropharynx; Stage I Mucoepidermoid Carcinoma of the Oral Cavity; Stage I Salivary Gland Cancer; Stage I Squamous Cell Carcinoma of the Hypopharynx; Stage I Squamous Cell Carcinoma of the Larynx; Stage I Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage I Squamous Cell Carcinoma of the Nasopharynx; Stage I Squamous Cell Carcinoma of the Oropharynx; Stage I Verrucous Carcinoma of the Larynx; Stage I Verrucous Carcinoma of the Oral Cavity; Stage II Adenoid Cystic Carcinoma of the Oral Cavity; Stage II Basal Cell Carcinoma of the Lip; Stage II Lymphoepithelioma of the Nasopharynx; Stage II Lymphoepithelioma of the Oropharynx; Stage II Mucoepidermoid Carcinoma of the Oral Cavity; Stage II Salivary Gland Cancer; Stage II Squamous Cell Carcinoma of the Hypopharynx; Stage II Squamous Cell Carcinoma of the Larynx; Stage II Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage II Squamous Cell Carcinoma of the Nasopharynx; Stage II Squamous Cell Carcinoma of the Oropharynx; Stage II Verrucous Carcinoma of the Larynx; Stage II Verrucous Carcinoma of the Oral Cavity; Stage III Adenoid Cystic Carcinoma of the Oral Cavity; Stage III Basal Cell Carcinoma of the Lip; Stage III Lymphoepithelioma of the Nasopharynx; Stage III Lymphoepithelioma of the Oropharynx; Stage III Mucoepidermoid Carcinoma of the Oral Cavity; Stage III Salivary Gland Cancer; Stage III Squamous Cell Carcinoma of the Hypopharynx; Stage III Squamous Cell Carcinoma of the Larynx; Stage III Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage III Squamous Cell Carcinoma of the Nasopharynx; Stage III Squamous Cell Carcinoma of the Oropharynx; Stage III Verrucous Carcinoma of the Larynx; Stage III Verrucous Carcinoma of the Oral Cavity; Stage IV Adenoid Cystic Carcinoma of the Oral Cavity; Stage IV Basal Cell Carcinoma of the Lip; Stage IV Lymphoepithelioma of the Nasopharynx; Stage IV Lymphoepithelioma of the Oropharynx; Stage IV Mucoepidermoid Carcinoma of the Oral Cavity; Stage IV Salivary Gland Cancer; Stage IV Squamous Cell Carcinoma of the Hypopharynx; Stage IV Squamous Cell Carcinoma of the Larynx; Stage IV Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage IV Squamous Cell Carcinoma of the Nasopharynx; Stage IV Squamous Cell Carcinoma of the Oropharynx; Stage IV Verrucous Carcinoma of the Larynx; Stage IV Verrucous Carcinoma of the Oral Cavity

  3. Charges in haemostasis during radiotherapy of uterine carcinoma

    Clinical chemical parameters for coagulation and fibrinolysis were determined in 20 patients suffering from uterine cancer both during radium implantation with low dose anticoagulation and during the time period of percutaneous post-irradiation. In spite of strong immobilization the partial anticoagulation stabilised haemostasis. A large increase in fibrinogen concentration within the normal range of values, caused by increased production and release from the outer areas of the tumour, cannot be prevented. In addition, in the majority of cases there is a drop in AT III concentration in the pathological range. Percutaneous post-irradiation treatment for further tumour regression leads to a stabilization of the overall tests for clotting. The activated fibrinolysis and elevated levels of fibrin clearage products noted at commencement of the tests showed a normalizing tendency with progressing tumour regression and this was accompanied by a decrease in fibrinogen concentration. A low-dose anticoagulation with 3 x 5000 USP E. Heparin subcutaneous can be recommended as clinical consequences for treating frequently adipose carcinomal patients. Optimal commencement of anticoagulation is 3 hr. pre-operative. (orig./MG)

  4. Radiation doses and neutron irridation effects on human cells based on calculations

    Radojevic, B. B.; Cukavac, M.; Jovanovic, D.

    In general, main aim of our paper is to follow influence of neutron's radiation on materials, but one of possible applications of fast neutrons in therapeutical reasons i.e. their influence on carcinom cells of difficuilt geometries in human bodies too. Interactions between neutrons and human cells of tissue are analysed here. We know that the light nuclei of hydrogen, nitrogen, carbon, and oxygen are main constituents of human cells, and that different nuclear models are usually used to present interactions of nuclear particles with mentioned elements. Some of most widely used pre-equilibrium nuclear models are: intranuclear cascade model (ICN), Harp-Miller-Berne (HMB), geometry-dependent hybrid (GDH) and exciton models (EM). In this paper is studied and calculated the primary energetic spectra of the secundary particles (neutrons, protons, and gamas) emitted from this interactions, and followed by corresponding integral cross sections, based on exciton model (EM). The total emission cross-section is the sum of emissions in all stages of energies. Obtained spectra for interactions type of (n, n'), (n, p), and (n, ?), for various incident neutron energies in the interval from 3 MeV up to 30 MeV are analysed too. Some results of calculations are presented here.

  5. [A member of the SRC gene family, the c-erbB-1 gene, is closely related to the EGF receptor gene].

    Yamamoto, T; Kawai, S; Toyoshima, K

    1985-03-01

    An avian erythroblastosis virus, AEV-H, induces both erythroblastosis and sarcomas in susceptible chickens. Since AEV-H carries the v-erbB as a sole oncogene, the erbB gene was suggested to be responsible for the induction of these tumors. Analysis of the amino acid sequence predicted from the nucleotide sequence of the v-erbB gene revealed that the gene product has a domain characteristic for tyrosine kinase. Recently in has been suggested has the v-erbB protein is a part of the chicken EGF (epidermal growth factor) receptor. Using antibody against either v-erbB protein or EGF receptor, we also demonstrated close similarity between the two proteins. Further studies on human genomic DNA revealed that the c-erbB-1 gene, a proto-oncogene of the v-erbB gene, is the EGF receptor gene. We were also able to identify the c-erbB-2 gene that seems to code for a EGF receptor-like protein with a domain for tyrosine kinase. Finally, we would like to show that cell lines established from human squamous cell carcinom are frequently associated with amplification of the c-erbB-1/EGF receptor gene. PMID:2984999

  6. [What is the role of cigarette smoking and various methods of contraception in the development of cervix cancer and its precancerous conditions?].

    Barten, G

    1990-01-01

    Basis of this trial are examinations of 100 patients with colposcopic and/or cytologic suspicion for precancerous or early stages of cancer of the uterine cervix and of 100 patients in the same age with normal cervical findings. The meaning discussed in literature about cigarette smoking as cofactor for developing cervical cancer and its prestages can be confirmed by our results. The portion of smoking patients with 74 per cent in the cervical groups was higher than in control group (42 per cent). Three times so much patients of the cervical group than in the controls smoked 20 cigarettes per day or more. More than 20 years smoking patients could be found only in the cervical group. 97 patients of the cervical group compared with 55 of the controls had been in the pill. Patients with cervical lesions on the average had been 3 years younger starting with hormonal contraception than the controls. The portion of pill users more than 10 years had been twice frequent in cervical group. The use of condoms was significantly more frequent in the control groups than in the cervical one (22/6). Therefore condoms are to be preferred be cause of protection against sexual transmitted diseases and indirectly cervical carcinom. PMID:2368529

  7. HYALINISING TRABECULAR TUMOR- THYROID

    Bharath

    2013-01-01

    Full Text Available ABSTRACT: BACKGROUND: Hyalinising trabecular tumors of thyroid is an in teresting but uncommon neoplasm of thyroid. This is presented bec ause of its peculiar morphologic features, including encapsulation, trabecular pattern and marke d hyalinization. OBJECTIVES: To know the morphologic feature and its histological behavio r. METHOD: Hemithyroidectomy specimen was received with fixative. The specimen was grossed , bits were taken from appropriate areas & processed in Histokinette, embedded in paraffin and t he serial sections were stained with Hematoxylin & Eosin. RESULTS: Histologically, showed encapsulated cellular growth , composed of follicular cells arranged in trabecular and foll icular pattern. They are separated by fibrous bands and areas of abundant hyalinization seen. The nuclei of the cells were vesicular with indistinct nucleoli, having pale vacuolated cytoplasm . CONCLUSION: Hyalinizing trabecular tumor is an uncommon neoplasm with its peculiar morph ologic features. It is sometimes mistaken for other neoplasm like- Papillary carcinom a, insular carcinoma & paraganglioma.. Hence histologic evaluation of cytomorphologic featu res is important for definitive diagnosis

  8. The MRI findings of iris metastasis in patients with breast cancer.

    Mutlu, Hasan; Akça, Zeki; Büyükçelik, Abdullah; Oztürk, Mustafa; Taşdemir, Mustafa; Kubilay Yazıcıoğlu, Alper; Kaplan, Bünyamin; Uçar, Kadir

    2012-12-01

    Breast cancer and lung cancer are the most common tumors that metastasize to iris. The metastasis of iris was generally diagnosed on ophthalmologic examination. In this case, we reported iris metastasis of patients with adenocarcinoma of breast cancer and MRI findings. We report a case of a 51-year-old. She was diagnosed breast cancer two years ago. After adjuvant chemotherapy, radiotherapy and trastuzumab, she was admitted to hospital with the complaints of headache on February 2012. The magnetic resonance imaging (MRI ) revealed multiple brain metastasis. Whole brain radiotherapy and palliative chemotherapy were applied to the patients. In follow-up, on ophthalmological examination, there was a solid lesion on iris. The orbital MRI was performed and it revealed the thickness on iris of left eye. After diagnostic procedure final pathological rewiev reported that invasive ductal carcinom metastasis. Iris metastasis may be considered by MRI findings following: The thickness on iris and contrast enhanced lesion. This reason may be resulted that the fine niddle aspiration biopsy for diagnosis of iris metastasis is not need. PMID:23378695

  9. [Inhibition of angiogenesis properties by SZ-21].

    Sheng, Ming; Hu, Xiao-Hui; Ruan, Chang-Geng

    2003-02-01

    The aim of this study is to screen out the monoclonal antibody reactive to a kind of endothelial cell line (ECV304) from SZ-1, -2, -21, -22, -51, -65, -262 and explore its function of anti-angiogenesis. The inhibitory effects of monoclonal antibody reactive to ECV304 and human lung carcinom cells (A549) adhesion and migration to extracellular matrix proteins (i.e, fibronectin and collagen IV) were studied by ELISA, the inhibition of angiogenesis in vivo was analyzed by chick chorioallantoic membrane (CAM) assays, the percentage of apoptotic cells in A549 cells was assayed by flow cytometric Annexin-V-FITC/PI dual labeling technique. The results showed that SZ-21 exhibited inhibitory effects on human umbilical vein endothelial cell line (ECV304) and pulmonary cancer cell line (A549) adhesion and migration to extracellular matrix proteins (i.e, fibronectin and collagen IV). In addition, it disrupted ongoing angiogenesis on the chick chorioallantoic membrane (CAM) model. SZ-21 also induced apoptosis of the A549 cells. In conclusion, SZ-21 inhibits angiogenesis in vivo and in vitro by blocking integrin beta(3) and inducing apoptosis. SZ-21 recognized the sequence beta(3) 28 - 35 which is far away from the RGD ligation site on GPIIIa. Integrin may interact the extracellular matrix via recognition sites other than RGD sequence. PMID:12667295

  10. Experimental production of antibodies against stratum corneum keratin polypeptides.

    Viac, J; Staquet, M J; Thivolet, J; Goujon, C

    1980-01-01

    Anti-keratin polypeptide sera (K.P.S) were obtained by immunizing guinea pigs with fibrous proteins from stratum corneum, which were acquired from normal human epidermis by m eans of S.D.S. polyacrylamide gel electrophoresis. After absorption with red blood cells and liver powder the sera were tested by indirect immunofluorescence technique on different substrates. Antibodies against polypeptides P1 and P2 of M.W. 67,000 and 62,000 dalton, respectively, were directed toward cytoplasmic Ag of keratinocytes of spinous and graunular layer of normal human and rabbit epidermis. No labeling could be detected in the basal cell layer. This finding is in favor of various differentiation stages of the keratinizing cells. P3 of M.W. 53,000 dalton induced low titre anibodies which labelled the whole epidermis, including the basal cell layer. The fourth polypeptide of M.W. 49,000 dalton seemed not to be immunogenic in such experiences. In tumors, such as basal cell carcinom,a squamous cell carcinoma, and warts, the expression of keratin antigens is markedly diminished. No analogy could be drawn between experimental keratin polypeptide antibodies and the human epidermal cytoplasmic antibodies which were detected in some patient sera. PMID:6157367

  11. THE MRI FINDINGS OF IRIS METASTASIS IN PATIENTS WITH BREAST CANCER

    Mutlu, Hasan; Akça, Zeki; Büyükçelik, Abdullah; Öztürk, Mustafa; Taşdemir, Mustafa; Kubilay Yazıcıoğlu, Alper; Kaplan, Bünyamin; Uçar, Kadir

    2012-01-01

    Breast cancer and lung cancer are the most common tumors that metastasize to iris. The metastasis of iris was generally diagnosed on ophthalmologic examination. In this case, we reported iris metastasis of patients with adenocarcinoma of breast cancer and MRI findings. We report a case of a 51-year-old. She was diagnosed breast cancer two years ago. After adjuvant chemotherapy, radiotherapy and trastuzumab, she was admitted to hospital with the complaints of headache on February 2012. The magnetic resonance imaging (MRI ) revealed multiple brain metastasis. Whole brain radiotherapy and palliative chemotherapy were applied to the patients. In follow-up, on ophthalmological examination, there was a solid lesion on iris. The orbital MRI was performed and it revealed the thickness on iris of left eye. After diagnostic procedure final pathological rewiev reported that invasive ductal carcinom metastasis. Iris metastasis may be considered by MRI findings following: The thickness on iris and contrast enhanced lesion. This reason may be resulted that the fine niddle aspiration biopsy for diagnosis of iris metastasis is not need. PMID:23378695

  12. Angiomyolipomes épithélioïdes rénal bénin: à propos de deux cas

    Bagayogo, Tidiani; Othmane, Yddoussalah; Tarik, Karmouni; Khalid, Elkhader; Abdellatif, Koutani; Ahmed, Ibn Attya Andaloussi

    2015-01-01

    Les angiomyolipomes épithélioïdes rénaux (AMLeR) sont des tumeurs rares (identifiées chez moins de 0,1 patients pour 1000 habitants) et représentent 8% des angiomyolipomes (AML) opérés. Il a longtemps été considérécomme un hamartome mais plusieurs articles récents font penser qu'il s'agir d'une tumeur dérivant de cellules épithélioïdespérivasculaires. L'angiomyolipome épithélioïde est une forme rare d'angiomyolipome à potentiel malin, composé decellules épithélioïdes posant des problèmes de diagnostic différentiel avec les carcinomes à cellules rénales. L'immunohistochimie,en révélant la positivité des cellules épithélioïdes au marqueur HMB45 est essentielle au diagnostic. Les auteursrapportent l'aspect tomodensitométrique et histologique d'angiomyolipomes épithélioïdes chez deux patientes. PMID:26953738

  13. La forme pseudo tumorale de la tuberculose primitive du nasopharynx: propos de deux nouvelles observations et revue de la littrature

    Touati, Mohammed; Aljalil, Abdelfettah; Chihani, Mehdi; Bouchentouf, Rachid; Bouaity, Brahim; Ammar, Haddou

    2013-01-01

    La tuberculose primitive du nasopharynx est rare, nous prsentons deux observations rvles par un aspect pseudo tumoral et travers lesquelles nous soulevons le problme de diagnostic diffrentiel avec les lsions malignes du nasopharynx. La premire observation concerne un jeune patient de 22 ans hospitalis pour obstruction nasale bilatrale voluant dans un contexte d'apyrexie et de conservation de ltat gnral. La nasofibrosopie et le scanner ont mont un processus tumoral voquant une hypertrophie des vgtations adnodes. Le deuxime cas est celui d'un homme de 45 ans tabagique chronique qui a prsent une adnopathie latrocervicale droite, une obstruction nasale et une otite sromuqueuse homolatrale. La nasophibroscopie et le scanner on montr un bourgeon tumoral postro latral droit du nasopharynx voquant un carcinome nasopharyng. Les biopsies du nasopharynx et les tudes histologiques, chez les deux patients, ont confirm le diagnostic de tuberculose. La recherche d'autres localisations tait ngative. Le pronostic tait favorable aprs 6 mois de traitement antibacillaire. La tuberculose primitive du cavum est rare, elle revt le plus souvent des formes pseudotumorales et pose des problmes de diagnostic diffrentiel avec les tumeurs nasopharynges, son pronostic sous traitement antibacillaire est. PMID:23565310

  14. Use of in vitro assays to assess the potential antiproliferative and cytotoxic effects of saffron (Crocus sativus L. in human lung cancer cell line

    Saeed Samarghandian

    2010-01-01

    Full Text Available Background: Saffron is harvested from the dried, dark red stigmas of Crocus sativus flowers. It is used as a spice for flavoring and coloring food as a perfume. It is often used for treating several diseases. We investigated the potential of the ethanolic extract of saffron to induce antiproliferative and cytotoxic effects in cultured carcinomic human alveolar basal epithelial cells in comparison with non-malignant (L929 cells. Materials and Methods: Both cells were cultured in Dulbecco′s modified Eagle′s medium and treated with the ethanolic extract of saffron at various concentrations for two consecutive days. Our study resulted in sequences of events marked by apoptosis, such as loss of cell viability, morphology changes that were evaluated by MTT assay and invert-microscope, respectively. Results: The results showed that the ethanolic extract of saffron decreased cell viability in malignant cells as a concentration and time-dependent manner. The IC 50 values against the lung cancer cell line were determined as 1500 and 565 μg/ml after 24 and 48 h, respectively. However, the extract at different concentrations could not significantly decrease the cell viability in L929 cells. Morphology of MCF7 cells treated with the ethanolic extract confirmed the MTT results. Conclusion: We also showed that even higher concentrations of saffron is safe for L929, but the extract exerts pro-apoptotic effects in a lung cancer-derived cell line and could be considered as a potential chemotherapeutic agent in lung cancer.

  15. Bevacizumab, Fluorouracil, and Hydroxyurea Plus Radiation Therapy in Treating Patients With Advanced Head and Neck Cancer

    2013-02-06

    Metastatic Squamous Neck Cancer With Occult Primary Squamous Cell Carcinoma; Recurrent Adenoid Cystic Carcinoma of the Oral Cavity; Recurrent Basal Cell Carcinoma of the Lip; Recurrent Esthesioneuroblastoma of the Paranasal Sinus and Nasal Cavity; Recurrent Inverted Papilloma of the Paranasal Sinus and Nasal Cavity; Recurrent Lymphoepithelioma of the Nasopharynx; Recurrent Lymphoepithelioma of the Oropharynx; Recurrent Metastatic Squamous Neck Cancer With Occult Primary; Recurrent Midline Lethal Granuloma of the Paranasal Sinus and Nasal Cavity; Recurrent Mucoepidermoid Carcinoma of the Oral Cavity; Recurrent Salivary Gland Cancer; Recurrent Squamous Cell Carcinoma of the Hypopharynx; Recurrent Squamous Cell Carcinoma of the Larynx; Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity; Recurrent Squamous Cell Carcinoma of the Nasopharynx; Recurrent Squamous Cell Carcinoma of the Oropharynx; Recurrent Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity; Recurrent Verrucous Carcinoma of the Larynx; Recurrent Verrucous Carcinoma of the Oral Cavity; Stage III Adenoid Cystic Carcinoma of the Oral Cavity; Stage III Basal Cell Carcinoma of the Lip; Stage III Esthesioneuroblastoma of the Paranasal Sinus and Nasal Cavity; Stage III Inverted Papilloma of the Paranasal Sinus and Nasal Cavity; Stage III Lymphoepithelioma of the Nasopharynx; Stage III Lymphoepithelioma of the Oropharynx; Stage III Midline Lethal Granuloma of the Paranasal Sinus and Nasal Cavity; Stage III Mucoepidermoid Carcinoma of the Oral Cavity; Stage III Salivary Gland Cancer; Stage III Squamous Cell Carcinoma of the Hypopharynx; Stage III Squamous Cell Carcinoma of the Larynx; Stage III Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage III Squamous Cell Carcinoma of the Nasopharynx; Stage III Squamous Cell Carcinoma of the Oropharynx; Stage III Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity; Stage III Verrucous Carcinoma of the Larynx; Stage III Verrucous Carcinoma of the Oral Cavity; Stage IV Adenoid Cystic Carcinoma of the Oral Cavity; Stage IV Basal Cell Carcinoma of the Lip; Stage IV Esthesioneuroblastoma of the Paranasal Sinus and Nasal Cavity; Stage IV Inverted Papilloma of the Paranasal Sinus and Nasal Cavity; Stage IV Lymphoepithelioma of the Nasopharynx; Stage IV Lymphoepithelioma of the Oropharynx; Stage IV Midline Lethal Granuloma of the Paranasal Sinus and Nasal Cavity; Stage IV Mucoepidermoid Carcinoma of the Oral Cavity; Stage IV Salivary Gland Cancer; Stage IV Squamous Cell Carcinoma of the Hypopharynx; Stage IV Squamous Cell Carcinoma of the Larynx; Stage IV Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage IV Squamous Cell Carcinoma of the Nasopharynx; Stage IV Squamous Cell Carcinoma of the Oropharynx; Stage IV Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity; Stage IV Verrucous Carcinoma of the Larynx; Stage IV Verrucous Carcinoma of the Oral Cavity; Untreated Metastatic Squamous Neck Cancer With Occult Primary

  16. Photodynamic Therapy Using HPPH in Treating Patients Undergoing Surgery for Primary or Recurrent Head and Neck Cancer

    2015-11-30

    Recurrent Adenoid Cystic Carcinoma of the Oral Cavity; Recurrent Basal Cell Carcinoma of the Lip; Recurrent Esthesioneuroblastoma of the Paranasal Sinus and Nasal Cavity; Recurrent Inverted Papilloma of the Paranasal Sinus and Nasal Cavity; Recurrent Lymphoepithelioma of the Nasopharynx; Recurrent Lymphoepithelioma of the Oropharynx; Recurrent Metastatic Squamous Neck Cancer With Occult Primary; Recurrent Midline Lethal Granuloma of the Paranasal Sinus and Nasal Cavity; Recurrent Mucoepidermoid Carcinoma of the Oral Cavity; Recurrent Salivary Gland Cancer; Recurrent Squamous Cell Carcinoma of the Hypopharynx; Recurrent Squamous Cell Carcinoma of the Larynx; Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity; Recurrent Squamous Cell Carcinoma of the Nasopharynx; Recurrent Squamous Cell Carcinoma of the Oropharynx; Recurrent Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity; Recurrent Thyroid Cancer; Recurrent Verrucous Carcinoma of the Larynx; Recurrent Verrucous Carcinoma of the Oral Cavity; Stage I Adenoid Cystic Carcinoma of the Oral Cavity; Stage I Basal Cell Carcinoma of the Lip; Stage I Esthesioneuroblastoma of the Paranasal Sinus and Nasal Cavity; Stage I Follicular Thyroid Cancer; Stage I Inverted Papilloma of the Paranasal Sinus and Nasal Cavity; Stage I Lymphoepithelioma of the Nasopharynx; Stage I Lymphoepithelioma of the Oropharynx; Stage I Midline Lethal Granuloma of the Paranasal Sinus and Nasal Cavity; Stage I Mucoepidermoid Carcinoma of the Oral Cavity; Stage I Papillary Thyroid Cancer; Stage I Salivary Gland Cancer; Stage I Squamous Cell Carcinoma of the Hypopharynx; Stage I Squamous Cell Carcinoma of the Larynx; Stage I Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage I Squamous Cell Carcinoma of the Oropharynx; Stage I Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity; Stage I Verrucous Carcinoma of the Larynx; Stage I Verrucous Carcinoma of the Oral Cavity; Stage II Adenoid Cystic Carcinoma of the Oral Cavity; Stage II Basal Cell Carcinoma of the Lip; Stage II Esthesioneuroblastoma of the Paranasal Sinus and Nasal Cavity; Stage II Follicular Thyroid Cancer; Stage II Inverted Papilloma of the Paranasal Sinus and Nasal Cavity; Stage II Lymphoepithelioma of the Nasopharynx; Stage II Lymphoepithelioma of the Oropharynx; Stage II Midline Lethal Granuloma of the Paranasal Sinus and Nasal Cavity; Stage II Mucoepidermoid Carcinoma of the Oral Cavity; Stage II Papillary Thyroid Cancer; Stage II Salivary Gland Cancer; Stage II Squamous Cell Carcinoma of the Hypopharynx; Stage II Squamous Cell Carcinoma of the Larynx; Stage II Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage II Squamous Cell Carcinoma of the Oropharynx; Stage II Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity; Stage II Verrucous Carcinoma of the Larynx; Stage II Verrucous Carcinoma of the Oral Cavity

  17. Anaplastic large-cell lymphoma presenting as a nasopharyngeal mass and cervical lymphadenopathy.

    Dion, Gregory R; Packer, Mark D

    2015-06-01

    Cervical lymphadenopathy in adults has a broad differential diagnosis, including bacterial and viral infections, Kikuchi-Fujimoto disease, systemic lupus erythematosus, and various neoplasms. Many of its etiologies share similar symptomatology and presentations, which complicates the diagnosis. A thorough history and a comprehensive physical examination, to include nasopharyngoscopy and imaging as indicated by the specific case, are key to determining the origin of the lymphadenopathy and to avoid a missed or delayed diagnosis. Based on our review of the literature, we present the second reported case of anaplastic lymphoma kinase-positive anaplastic large-cell lymphoma presenting in an adult with an obstructing adenoid/nasopharyngeal mass and lymphadenopathy. The mass, which occurred in a 19-year-old woman of Asian descent, caused nasal airway obstruction in the setting of cervical lymphadenopathy that was initially ascribed to mononucleosis. PMID:26053987

  18. [The prevalence and structure of ENT diseases in the children residing in the industrial regions].

    Sineva, E L; Pankova, V B; Sarancha, E O

    2015-01-01

    The present study was designed to evaluate the state of the ENT organs in the children residing in the industrial regions characterized by the enhanced level of atmospheric pollution. The results of the correlation analysis of the data obtained confirm the strong cause-and-effect relationship between the pathologies of the upper respiratory tract (such as allergic and catarrhal rhinitis, chronic pharyngitis, sinusitis, inflammatory tonsillar diseases, and adenoid vegetations), impaired local immune reactivity, and the index of general air pollution including that with nitrous dioxide, phenols, and particulate matter. The results of the study suggest the necessity of more active detection of ENT diseases in the children at the early stages of their development together with regular medical examinations, and the implementation of purpose-oriented prophylactic, therapeutic, and health promoting measures. PMID:26145745

  19. [Obstructive sleep apnea syndrome in children].

    Aubertin, G

    2013-08-01

    Obstructive sleep apnea (OSA) is highly prevalent in school-aged children. Tonsillar and/or adenoids hypertrophy is the most common etiology of OSA in children. OSA has been associated with sleep quality disturbance (frequent arousals) and nocturnal gas-exchange abnormalities (hypoxemia and sometimes hypercapnia), complicated with a large array of negative health outcomes. The clinical symptoms are not able to distinguish primary snoring from OSA. Polysomnography remains the gold standard for the diagnosis of sleep disordered breathing, but the demand is increasing for this highly technical sleep test. So, some other simpler diagnostic methods are available, as respiratory polygraphy, but need to be validated in children. Treatment of OSA in children must be based on a mutlidisciplinary approach with pediatricians, ENT surgeons and orthodontists. PMID:23870386

  20. Malignant tumours of the parotid: a study of 76 patients.

    Marandas, P; Dharkar, D; Davis, A; Leridant, A M; Pacheco Ojeda, L; Micheau, C; Wibault, P; Schwaab, G

    1990-04-01

    This study presents a series of malignant parotid tumours treated at the Institut Gustave-Roussy between 1975 and 1984. The lesions represented a wide variety of histological types. Few preoperative investigations were required, management being based on histology. Effective local control requires a total parotidectomy preserving the facial nerve where possible. It should be followed by routine radiotherapy which appears to reduce the incidence of local recurrence. The rate of local recurrence also depends on the histological type. It is seen more frequently in an adenocarcinoma following a pleomorphic adenoma than in simple adenocarcinoma. Patients with inoperable disease are treated with radiotherapy alone as chemotherapy has not so far been effective. Percentage 5-year survival for the three most common tumour types is as follows: adenocarcinoma: 49; adenoid cystic carcinoma: 83, and mucoepidermoid carcinoma: 75. PMID:2161717

  1. Incidentally found and unexpected tumors discovered by MRI examination for temporomandibular joint arthrosis

    Yanagi, Yoshinobu; Asaumi, Jun-ichi E-mail: asaumi@md.okayama-u.ac.jp; Maki, Yuu; Murakami, Jun; Hisatomi, Miki; Matsuzaki, Hidenobu; Konouchi, Hironobu; Honda, Yosutoshi; Kishi, Kanji

    2003-07-01

    We examined the frequency of incidentally found or unexpected tumors discovered at the time of magnetic resonance imaging (MRI) examinations in the temporomandibular joint (TMJ) region for patients with suspicion of TMJ arthrosis. Five MR images (T1-weighted transverse scout image and proton density and T2-weighted oblique sagittal images at the open and closed mouth) were acquired. In 2776 MRI examinations of TMJ arthrosis, two tumors were discovered. They consisted of an adenoid cystic carcinoma in the deep portion of the parotid gland, and a malignant tumor extending from the infratemporal fossa to the parapharyngeal space. The rate of incidentally founded or unexpected tumors in TMJ examinations was low (0.072%), but the two tumors found were malignant tumors, and therefore, scout image should be carefully examined, not only used for positing the slice.

  2. A CHILD WITH EPISTAXIS, REDUCED HEARING AND CERVICAL LYMPHADENOPATHY: A RARE CASE OF NASOPHARYNGEAL CARCINOMA IN A CHILD

    SUHAIMI Y

    2011-01-01

    Full Text Available Although nasopharyngeal carcinoma (NPC is common in this part of the world, the incidence among children is still very low worldwide. The diagnosis is sometimes delayed because of the late reporting of the symptom by the patient or parents, or difficulty in reaching the final diagnosis due to its hidden anatomical location. The challenges include the difficult endoscopy in children, inability to differentiate an adenoid from the tumour on radiograph and often the inconclusive fine needle aspiration findings. If the tumour mass at Fossa of Rosenmuller can be clearly appreciated and biopsied with undoubtedly proven histology of NPC, the diagnosis can be straight forward and treatment can be commenced as early as possible. We report a 10-year-old child presented with bilateral neck cervical lymphadenopathy and epistaxis with fine needle aspiration cytology(FNAC of the neck mass reported as lymphoma. Further work-up confirmed he was suffering from NPC.

  3. Calculation of neutron kerma in tissues

    Neutron kerma of normal and tumor tissues has been calculated using the tissues elemental concentration. A program developed in Math cad contains the kerma factors of C, H, O, N, Na, Mg, P, S, Cl, K, etc. that are in normal and tumor human tissues. Having the elemental composition of any human tissue the neutron kerma can be calculated. The program was tested using the elemental composition of tumor tissues such as sarcoma, melanoma, carcinoma and adenoid cystic, also neutron kerma for adipose and muscle tissue for normal adult was calculated. The results are in agreement with those published in literature. The neutron kerma for water was also calculated because in some dosimetric calculations water is used to describe normal and tumor tissues. From this comparison was found that at larger energies kerma factors are approximately the same, but energies less than 100 eV the differences are large. (Author)

  4. Calculation of neutron kerma in tissues

    Vega C, H.R.; Manzanares A, E. [Unidades Academicas de Estudios Nucleares, Ing. Electrica y Matematicas, Universidad Autonoma de Zacatecas, A.P. 336, 98000 Zacatecas (Mexico)]. E-mail: rvega@cantera.reduaz.mx

    2004-07-01

    Neutron kerma of normal and tumor tissues has been calculated using the tissues elemental concentration. A program developed in Math cad contains the kerma factors of C, H, O, N, Na, Mg, P, S, Cl, K, etc. that are in normal and tumor human tissues. Having the elemental composition of any human tissue the neutron kerma can be calculated. The program was tested using the elemental composition of tumor tissues such as sarcoma, melanoma, carcinoma and adenoid cystic, also neutron kerma for adipose and muscle tissue for normal adult was calculated. The results are in agreement with those published in literature. The neutron kerma for water was also calculated because in some dosimetric calculations water is used to describe normal and tumor tissues. From this comparison was found that at larger energies kerma factors are approximately the same, but energies less than 100 eV the differences are large. (Author)

  5. Neutron KERMA factors of human tissues

    A program to calculate the neutron KERMA in human tissues has been developed. The program was developed in Mathcad and contains the neutron kerma factors of those elements that are present in different human tissues. Having the elemental composition of any human tissue the neutron kerma can be easily calculated. The program was tested using the elemental composition of tumor tissues such as sarcoma, melanoma, carcinoma and adenoid cystic. Neutron kerma for adipose and muscle tissue for normal adult was calculated. The results are in agreement with those published in literature. The neutron kerma for water was also calculated because in some dosimetric calculations water is used to describe normal and tumor tissues. From this comparison was found that at larger energies kerma factors are approximately the same, but energies less than 100 eV the differences are large (au)

  6. Clinical analysis of 47 primary parotid cancers

    A retrospective study was performed on 47 patients with primary malignant neoplasms of the parotid gland treated in our department between 1982 and 1999. Most of the patients were male and over age 40, and 23 patients were of stage IV in clinical classification. The most frequently observed histological type was adenocarcinoma (12 patients), and the next was adenoid cystic carcinoma (11 patients). A radical parotidectomy with postoperative radiation therapy was administered in 38 patients, and palliative treatment in 9. The global survival rate was 74.1% at 5 years, and 89.4% in the patients treated with the radical procedure. Radical operative treatment and subsequent over 50-Gy of irradiation supposed to be the important factor to improve the prognosis. (author)

  7. Does the type of rhinitis influence development of otitis media with effusion in children?

    Quaranta, Nicola; Iannuzzi, Lucia; Gelardi, Matteo

    2014-11-01

    Otitis media with effusion (OME) is characterized by the presence of fluid in the middle ear cavity behind an intact eardrum and is considered a multifactorial condition with Eustachian tube dysfunction as the underlying pathophysiologic condition. One of the most debated causes of OME is allergy, in particular allergic rhinitis. The aim of this paper is to review the role of rhinitis in the development of OME and in particular the role of both allergic (AR) and non-allergic rhinitis (NAR). Most of the recent literature confirms the role of AR in the development of OME, while there are few reports on the role of NAR. In non-allergic children affected by obstructive adenoid hypertrophy, the presence of mast cells in the nasal smear was associated with a high risk of developing a chronic OME. PMID:25183363

  8. Tracheal resection and reconstruction for malignant disease

    Zuin, Andrea

    2016-01-01

    Malignant tracheal neoplasms are rare diseases, mostly represented by squamous cell carcinoma (SCC) and adenoid cystic carcinoma (ACC). Symptoms presentation is often misleading and diagnosis may be delayed for months or years, so clinical suspicion plays a fundamental role. Corner stones in the diagnostic pathway are represented by rigid endoscopy and computed tomography (CT) scan, necessary to correctly stage the patients and identify the optimal surgical candidate. When appropriate, surgical resection and reconstruction is still the best opportunity to achieve a long-term survival with a good quality of life, but this kind of surgery is always a very challenging procedure and a wide experience with an in-depth knowledge of every technical detail, from selection of patient, to choice of surgical approach to reconstruction techniques, are needed and recommended.

  9. Myoepithelial Carcinoma of the Nasopharynx: Report of a Rare Case and a Review of the Literature.

    Soon, Gwyneth; Petersson, Fredrik

    2015-12-01

    Salivary gland carcinomas are very rare in the nasopharynx, with the most frequent histologic types being adenoid cystic carcinoma, mucoepidermoid carcinoma and adenocarcinoma, not otherwise specified. Myoepithelial carcinoma (MECA) is a rare tumor of the salivary glands, and there are only three previously reported cases of nasopharyngeal MECA. The case presented is the fourth reported case of MECA in the nasopharynx. Due to the morphologic heterogeneity of MECA, immunohistochemistry is indispensable in ascertaining the diagnosis. MECA is a locally aggressive tumor, but the long-term prognosis of this tumor in the nasopharynx remains uncertain. In our case the tumor was unresectable and the patient was given chemo-radiotherapy. Despite this, residual tumor was seen on nasoscopy 5 months after initial diagnosis and was documented on a re-biopsy which displayed the same histomorphologic features as the original tumor. PMID:26115759

  10. Necrotizing sialometaplasia: Report of 2 cases

    Nah, Kyung Soo; Cho, Bong Hae; Jung, Yun Hoa [Pusan National Univ. College of Dentistry, Busan (Korea, Republic of)

    2006-12-15

    Necrotizing sialometaplasia (NS) was defined by Abrams et al. in 1973 as a reactive necrotizing inflammatory process involving minor salivary glands of the hard palate. Before that recognition, many patients with this condition had been improperly treated because of its clinical and histologic resemblance to malignancy such as mucoepidermoid carcinoma and squamous cell carcinoma. We report two cases of necrotizing sialometaplasia. One case involved a 58-year-old male who had an ulcerative palatal lesion exposing underlying bone which has the typical features of the above mentioned condition. Another case involved a 59-year-old male who developed a necrotizing sialometaplasia in association with a dome-shaped palatal swelling which was proves as an adenoid cystic carcinoma after operation biopsy.

  11. Gefitinib in Treating Patients With Metastatic or Unresectable Head and Neck Cancer or Non-Small Cell Lung Cancer

    2013-01-11

    Anaplastic Thyroid Cancer; Insular Thyroid Cancer; Metastatic Parathyroid Cancer; Recurrent Adenoid Cystic Carcinoma of the Oral Cavity; Recurrent Basal Cell Carcinoma of the Lip; Recurrent Esthesioneuroblastoma of the Paranasal Sinus and Nasal Cavity; Recurrent Inverted Papilloma of the Paranasal Sinus and Nasal Cavity; Recurrent Lymphoepithelioma of the Nasopharynx; Recurrent Lymphoepithelioma of the Oropharynx; Recurrent Metastatic Squamous Neck Cancer With Occult Primary; Recurrent Midline Lethal Granuloma of the Paranasal Sinus and Nasal Cavity; Recurrent Mucoepidermoid Carcinoma of the Oral Cavity; Recurrent Non-small Cell Lung Cancer; Recurrent Parathyroid Cancer; Recurrent Salivary Gland Cancer; Recurrent Squamous Cell Carcinoma of the Hypopharynx; Recurrent Squamous Cell Carcinoma of the Larynx; Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity; Recurrent Squamous Cell Carcinoma of the Nasopharynx; Recurrent Squamous Cell Carcinoma of the Oropharynx; Recurrent Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity; Recurrent Thyroid Cancer; Recurrent Verrucous Carcinoma of the Larynx; Stage III Follicular Thyroid Cancer; Stage III Papillary Thyroid Cancer; Stage III Salivary Gland Cancer; Stage III Squamous Cell Carcinoma of the Hypopharynx; Stage III Squamous Cell Carcinoma of the Larynx; Stage III Verrucous Carcinoma of the Larynx; Stage IIIB Non-small Cell Lung Cancer; Stage IV Lymphoepithelioma of the Nasopharynx; Stage IV Non-small Cell Lung Cancer; Stage IV Squamous Cell Carcinoma of the Hypopharynx; Stage IV Squamous Cell Carcinoma of the Nasopharynx; Stage IVA Adenoid Cystic Carcinoma of the Oral Cavity; Stage IVA Basal Cell Carcinoma of the Lip; Stage IVA Esthesioneuroblastoma of the Paranasal Sinus and Nasal Cavity; Stage IVA Follicular Thyroid Cancer; Stage IVA Inverted Papilloma of the Paranasal Sinus and Nasal Cavity; Stage IVA Lymphoepithelioma of the Oropharynx; Stage IVA Midline Lethal Granuloma of the Paranasal Sinus and Nasal Cavity; Stage IVA Mucoepidermoid Carcinoma of the Oral Cavity; Stage IVA Papillary Thyroid Cancer; Stage IVA Salivary Gland Cancer; Stage IVA Squamous Cell Carcinoma of the Larynx; Stage IVA Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage IVA Squamous Cell Carcinoma of the Oropharynx; Stage IVA Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity; Stage IVA Verrucous Carcinoma of the Larynx; Stage IVA Verrucous Carcinoma of the Oral Cavity; Stage IVB Adenoid Cystic Carcinoma of the Oral Cavity; Stage IVB Basal Cell Carcinoma of the Lip; Stage IVB Esthesioneuroblastoma of the Paranasal Sinus and Nasal Cavity; Stage IVB Follicular Thyroid Cancer; Stage IVB Inverted Papilloma of the Paranasal Sinus and Nasal Cavity; Stage IVB Lymphoepithelioma of the Oropharynx; Stage IVB Midline Lethal Granuloma of the Paranasal Sinus and Nasal Cavity; Stage IVB Mucoepidermoid Carcinoma of the Oral Cavity; Stage IVB Papillary Thyroid Cancer; Stage IVB Salivary Gland Cancer; Stage IVB Squamous Cell Carcinoma of the Larynx; Stage IVB Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage IVB Squamous Cell Carcinoma of the Oropharynx; Stage IVB Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity; Stage IVB Verrucous Carcinoma of the Larynx; Stage IVB Verrucous Carcinoma of the Oral Cavity; Stage IVC Adenoid Cystic Carcinoma of the Oral Cavity; Stage IVC Basal Cell Carcinoma of the Lip; Stage IVC Esthesioneuroblastoma of the Paranasal Sinus and Nasal Cavity; Stage IVC Follicular Thyroid Cancer; Stage IVC Inverted Papilloma of the Paranasal Sinus and Nasal Cavity; Stage IVC Lymphoepithelioma of the Oropharynx; Stage IVC Midline Lethal Granuloma of the Paranasal Sinus and Nasal Cavity; Stage IVC Mucoepidermoid Carcinoma of the Oral Cavity; Stage IVC Papillary Thyroid Cancer; Stage IVC Salivary Gland Cancer; Stage IVC Squamous Cell Carcinoma of the Larynx; Stage IVC Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage IVC Squamous Cell Carcinoma of the Oropharynx; Stage IVC Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity; Stage IVC Verrucous Carcinoma of the Larynx; Stage IVC Verrucous Carcinoma of the Oral Cavity; Thryoid Gland Nonmedullary Carcinoma; Thyroid Gland Medullary Carcinoma; Tongue Cancer; Untreated Metastatic Squamous Neck Cancer With Occult Primary

  12. Necrotizing sialometaplasia: Report of 2 cases

    Necrotizing sialometaplasia (NS) was defined by Abrams et al. in 1973 as a reactive necrotizing inflammatory process involving minor salivary glands of the hard palate. Before that recognition, many patients with this condition had been improperly treated because of its clinical and histologic resemblance to malignancy such as mucoepidermoid carcinoma and squamous cell carcinoma. We report two cases of necrotizing sialometaplasia. One case involved a 58-year-old male who had an ulcerative palatal lesion exposing underlying bone which has the typical features of the above mentioned condition. Another case involved a 59-year-old male who developed a necrotizing sialometaplasia in association with a dome-shaped palatal swelling which was proves as an adenoid cystic carcinoma after operation biopsy

  13. [Salivary gland-type lung tumor: An update].

    Gibault, Laure; Badoual, Cécile

    2016-01-01

    "Salivary gland-type" tumors arising from the bronchi and lung are rare but not exceptional entities. They are mostly represented by malignant entities such as cystic adenoid carcinoma, mucoepidermoid carcinoma and epithelial/myoepithelial carcinoma. Benign tumors are rare, mainly encompassing pleomorphic adenomas, which are to differentiate from mucous gland adenomas, another entity arising specifically from the peri-bronchial glands. These tumours develop in the proximal bronchi and are not associated with smoke abuse. Their main treatment is surgery. It is important to differentiate them from other broncho-pulmonary tumours as they do not share the same prognosis and therapeutic. This article will review the WHO 2015 classification of these tumours as well as recent updates from the literature to help define diagnosis criteria for these uncommon entities. PMID:26774826

  14. Malignant salivary gland tumours

    Thompson, S.H. (University of the Witwatersrand, Johannesburg (South Africa). Dept. of Oral Pathology)

    1982-08-01

    The most frequent malignant salivary gland tumours are the mucoepidermoid tumour, adenoid cystic carcinoma and adenocarcinoma. The major salivary glands and the minor glands of the mouth and upper respiratory tract may potentially develop any of these malignant lesions. Malignant lesions most frequently present as a palpable mass and tend to enlarge more rapidly than benign neoplasms. Pain, paresthesia, muscle paralysis and fixation to surrounding tissue are all ominous signs and symptoms. The only reliable means of differential diagnosis of these lesions is biopsy and histologic analysis. Therapy involves surgery or a combination of surgery and radiation therapy. The ultimate prognosis is governed by the intrinsic biologic behaviour of the neoplasms, the extent of disease and adequate clinical therapy.

  15. CT and MR imaging findings of palatal tumors

    Kato, Hiroki, E-mail: hkato@gifu-u.ac.jp [Department of Radiology, Gifu University School of Medicine, 1-1 Yanagido, Gifu 501-1194 (Japan); Kanematsu, Masayuki, E-mail: masa_gif@yahoo.co.jp [Department of Radiology, Gifu University School of Medicine, 1-1 Yanagido, Gifu 501-1194 (Japan); High-level Imaging Diagnosis Center, Gifu University Hospital, 1-1 Yanagido, Gifu 501-1194 (Japan); Makita, Hiroki, E-mail: makitah@gifu-u.ac.jp [Department of Oral and Maxillofacial Sciences, Gifu University School of Medicine, Gifu (Japan); Kato, Keizo, E-mail: keizo@gifu-u.ac.jp [Department of Oral and Maxillofacial Sciences, Gifu University School of Medicine, Gifu (Japan); Hatakeyama, Daijiro, E-mail: hatakeya@gifu-u.ac.jp [Department of Oral and Maxillofacial Sciences, Gifu University School of Medicine, Gifu (Japan); Shibata, Toshiyuki, E-mail: shibat@gifu-u.ac.jp [Department of Oral and Maxillofacial Sciences, Gifu University School of Medicine, Gifu (Japan); Mizuta, Keisuke, E-mail: kmizuta@gifu-u.ac.jp [Department of Otolaryngology, Gifu University School of Medicine, Gifu (Japan); Aoki, Mitsuhiro, E-mail: aoki@gifu-u.ac.jp [Department of Otolaryngology, Gifu University School of Medicine, Gifu (Japan)

    2014-03-15

    Palatal tumors commonly arise from the minor salivary glands, and benign tumors account for approximately half of all minor salivary gland tumors. Minor salivary gland tumors have an affinity for the posterior hard palate and soft palate and virtually never arise in the midline, probably because of the distribution of palatal salivary glands. The majority of benign salivary gland tumors of the palate are pleomorphic adenomas, while the most common malignant salivary gland tumor is adenoid cystic carcinoma, followed by mucoepidermoid carcinoma, adenocarcinoma, and polymorphous low-grade adenocarcinoma. Epithelial tumors frequently arise from the soft palate. The majority of benign epithelial tumors of the palate are papillomas, while most malignant epithelial tumors are squamous cell carcinomas. Various types of mesenchymal tumors, including fibromas, lipomas, schwannomas, neurofibromas, hemangiomas, and lymphangiomas, also involve the palate. This article describes the CT and MR findings of benign and malignant palatal tumors.

  16. Evaluation of salivary gland tumors with 99mTc-pertechnetate

    Ishikawa, H.; Ishii, Y.

    1984-07-01

    The clinical efficacy of salivary gland scintigraphy was evaluated in 32 histologically proven cases. In benign tumors, except Warthin's tumor, 16 of the 20 cases (80%) appeared as cold lesions. All six cases of Warthin's tumor appeared as hot lesions. In malignant tumors, one case each of mucoepidermoid carcinoma, adenopapillary carcinoma, and adenoid-cystic carcinoma were shown as cold lesions, while squamous cell carcinoma and malignant mixed tumor were delineated as a defect image (no uptake of radionuclide). On stimulation with ascorbic acid, retention of radionuclide within the tumor was noted only in Warthin's tumors, but it was noted at the periphery of the tumors in 21 of the 24 cases (87.5%), which might be due to inflammation and/or compression of the gland by the tumors. Salivary gland scintigraphy provided useful information for the evaluation of the site of the tumor and the function of the salivary gland.

  17. Surgery for Malignant Sublingual and Minor Salivary Gland Neoplasms.

    Bradley, Patrick J; Ferris, Robert L

    2016-01-01

    Malignant sublingual gland neoplasms are rare, early-stage neoplasms presenting as painless non-ulcerated masses in the antero-lateral floor of the mouth. The majority of patients present with advanced disease, with symptoms of pain or anaesthesia of the tongue. Malignant minor salivary gland neoplasms are more common, the majority (>80%) of which present in the oral cavity, most frequently in the palatal area, as painless masses or as obstructive symptoms in the head and neck region. The most frequent pathologies are adenoid cystic carcinoma and mucoepidermoid carcinoma (>85%), with the majority presenting at an advanced stage (III/IV). Wide tumour-free surgical margin excision is the treatment of choice, followed by radiotherapy, after discussion of the multidisciplinary head and neck cancer tumour board. Improvements in survival and quality of life have been achieved since the introduction of endoscopic and robotic surgeries for many minor salivary gland malignancies. PMID:27092950

  18. CT and MR imaging findings of palatal tumors

    Palatal tumors commonly arise from the minor salivary glands, and benign tumors account for approximately half of all minor salivary gland tumors. Minor salivary gland tumors have an affinity for the posterior hard palate and soft palate and virtually never arise in the midline, probably because of the distribution of palatal salivary glands. The majority of benign salivary gland tumors of the palate are pleomorphic adenomas, while the most common malignant salivary gland tumor is adenoid cystic carcinoma, followed by mucoepidermoid carcinoma, adenocarcinoma, and polymorphous low-grade adenocarcinoma. Epithelial tumors frequently arise from the soft palate. The majority of benign epithelial tumors of the palate are papillomas, while most malignant epithelial tumors are squamous cell carcinomas. Various types of mesenchymal tumors, including fibromas, lipomas, schwannomas, neurofibromas, hemangiomas, and lymphangiomas, also involve the palate. This article describes the CT and MR findings of benign and malignant palatal tumors

  19. Impact of local radiation in the management of salivary gland carcinomas

    Seventy patients with salivary gland carcinoma (63% major gland and 37% minor gland) are reviewed. Histologies included adenoid cystic (54%), mucoepidermoid (16%), and adenocarcinoma (14%). Patients were analyzed according to extent of surgery and whether or not adjuvant postoperative radiotherapy was given. There is no difference in survival in patients who had complete excision of gross tumor with or without adjuvant radiotherapy. Patients who did not undergo radiotherapy had a 62% actuarial risk of locoregional failure at 5 years, with a 20% risk in the adjuvantly irradiated group (P less than 0.001). A failure analysis demonstrates that among the 44% of patients with recurrence 71% (22/31) failed locoregionally and 69% (21/31) had distant metastases. Twenty-seven percent (19/70) died of disease, with 31% (6/19) dying of locoregional disease and 26% (5/19) of distant disease. Implications for management are discussed

  20. Bevacizumab in Reducing CNS Side Effects in Patients Who Have Undergone Radiation Therapy to the Brain for Primary Brain Tumor, Meningioma, or Head and Neck Cancer

    2014-04-21

    Adult Anaplastic Astrocytoma; Adult Anaplastic Ependymoma; Adult Anaplastic Meningioma; Adult Anaplastic Oligodendroglioma; Adult Brain Stem Glioma; Adult Central Nervous System Germ Cell Tumor; Adult Choroid Plexus Tumor; Adult Diffuse Astrocytoma; Adult Ependymoma; Adult Grade II Meningioma; Adult Grade III Meningioma; Adult Malignant Hemangiopericytoma; Adult Mixed Glioma; Adult Oligodendroglioma; Adult Papillary Meningioma; Adult Pineocytoma; Malignant Neoplasm; Meningeal Melanocytoma; Radiation Toxicity; Recurrent Adenoid Cystic Carcinoma of the Oral Cavity; Recurrent Adult Brain Tumor; Recurrent Basal Cell Carcinoma of the Lip; Recurrent Esthesioneuroblastoma of the Paranasal Sinus and Nasal Cavity; Recurrent Inverted Papilloma of the Paranasal Sinus and Nasal Cavity; Recurrent Lymphoepithelioma of the Nasopharynx; Recurrent Lymphoepithelioma of the Oropharynx; Recurrent Midline Lethal Granuloma of the Paranasal Sinus and Nasal Cavity; Recurrent Mucoepidermoid Carcinoma of the Oral Cavity; Recurrent Salivary Gland Cancer; Recurrent Squamous Cell Carcinoma of the Hypopharynx; Recurrent Squamous Cell Carcinoma of the Larynx; Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity; Recurrent Squamous Cell Carcinoma of the Nasopharynx; Recurrent Squamous Cell Carcinoma of the Oropharynx; Recurrent Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity; Recurrent Verrucous Carcinoma of the Larynx; Recurrent Verrucous Carcinoma of the Oral Cavity; Stage I Adenoid Cystic Carcinoma of the Oral Cavity; Stage I Basal Cell Carcinoma of the Lip; Stage I Esthesioneuroblastoma of the Paranasal Sinus and Nasal Cavity; Stage I Inverted Papilloma of the Paranasal Sinus and Nasal Cavity; Stage I Lymphoepithelioma of the Nasopharynx; Stage I Lymphoepithelioma of the Oropharynx; Stage I Midline Lethal Granuloma of the Paranasal Sinus and Nasal Cavity; Stage I Mucoepidermoid Carcinoma of the Oral Cavity; Stage I Salivary Gland Cancer; Stage I Squamous Cell Carcinoma of the Hypopharynx; Stage I Squamous Cell Carcinoma of the Larynx; Stage I Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage I Squamous Cell Carcinoma of the Nasopharynx; Stage I Squamous Cell Carcinoma of the Oropharynx; Stage I Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity; Stage I Verrucous Carcinoma of the Larynx; Stage I Verrucous Carcinoma of the Oral Cavity; Stage III Adenoid Cystic Carcinoma of the Oral Cavity; Stage III Basal Cell Carcinoma of the Lip; Stage III Esthesioneuroblastoma of the Paranasal Sinus and Nasal Cavity; Stage III Inverted Papilloma of the Paranasal Sinus and Nasal Cavity; Stage III Lymphoepithelioma of the Nasopharynx; Stage III Midline Lethal Granuloma of the Paranasal Sinus and Nasal Cavity; Stage III Mucoepidermoid Carcinoma of the Oral Cavity; Stage III Salivary Gland Cancer; Stage III Squamous Cell Carcinoma of the Hypopharynx; Stage III Squamous Cell Carcinoma of the Larynx; Stage III Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage III Squamous Cell Carcinoma of the Nasopharynx; Stage III Squamous Cell Carcinoma of the Oropharynx; Stage III Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity; Stage III Verrucous Carcinoma of the Larynx; Stage III Verrucous Carcinoma of the Oral Cavity; Stage IV Adenoid Cystic Carcinoma of the Oral Cavity; Stage IV Basal Cell Carcinoma of the Lip; Stage IV Esthesioneuroblastoma of the Paranasal Sinus and Nasal Cavity; Stage IV Inverted Papilloma of the Paranasal Sinus and Nasal Cavity; Stage IV Lymphoepithelioma of the Nasopharynx; Stage IV Lymphoepithelioma of the Oropharynx; Stage IV Midline Lethal Granuloma of the Paranasal Sinus and Nasal Cavity; Stage IV Mucoepidermoid Carcinoma of the Oral Cavity; Stage IV Salivary Gland Cancer; Stage IV Squamous Cell Carcinoma of the Hypopharynx; Stage IV Squamous Cell Carcinoma of the Larynx; Stage IV Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage IV Squamous Cell Carcinoma of the Nasopharynx; Stage IV Squamous Cell Carcinoma of the Oropharynx; Stage IV Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity; Stage IV Verrucous Carcinoma of the Larynx; Stage IV Verrucous Carcinoma of the Oral Cavity

  1. Impact of local radiation in the management of salivary gland carcinomas

    Eapen, L.J.; Gerig, L.H.; Catton, G.E.; Danjoux, C.E.; Girard, A.

    1988-03-01

    Seventy patients with salivary gland carcinoma (63% major gland and 37% minor gland) are reviewed. Histologies included adenoid cystic (54%), mucoepidermoid (16%), and adenocarcinoma (14%). Patients were analyzed according to extent of surgery and whether or not adjuvant postoperative radiotherapy was given. There is no difference in survival in patients who had complete excision of gross tumor with or without adjuvant radiotherapy. Patients who did not undergo radiotherapy had a 62% actuarial risk of locoregional failure at 5 years, with a 20% risk in the adjuvantly irradiated group (P less than 0.001). A failure analysis demonstrates that among the 44% of patients with recurrence 71% (22/31) failed locoregionally and 69% (21/31) had distant metastases. Twenty-seven percent (19/70) died of disease, with 31% (6/19) dying of locoregional disease and 26% (5/19) of distant disease. Implications for management are discussed.

  2. Malignant salivary gland tumours

    The most frequent malignant salivary gland tumours are the mucoepidermoid tumour, adenoid cystic carcinoma and adenocarcinoma. The major salivary glands and the minor glands of the mouth and upper respiratory tract may potentially develop any of these malignant lesions. Malignant lesions most frequently present as a palpable mass and tend to enlarge more rapidly than benign neoplasms. Pain, paresthesia, muscle paralysis and fixation to surrounding tissue are all ominous signs and symptoms. The only reliable means of differential diagnosis of these lesions is biopsy and histologic analysis. Therapy involves surgery or a combination of surgery and radiation therapy. The ultimate prognosis is governed by the intrinsic biologic behaviour of the neoplasms, the extent of disease and adequate clinical therapy

  3. Evaluation of salivary gland tumors with 99mTc-pertechnetate

    The clinical efficacy of salivary gland scintigraphy was evaluated in 32 histologically proven cases. In benign tumors, except Warthin's tumor, 16 of the 20 cases (80%) appeared as cold lesions. All six cases of Warthin's tumor appeared as hot lesions. In malignant tumors, one case each of mucoepidermoid carcinoma, adenopapillary carcinoma, and adenoid-cystic carcinoma were shown as cold lesions, while squamous cell carcinoma and malignant mixed tumor were delineated as a defect image (no uptake of radionuclide). On stimulation with ascorbic acid, retention of radionuclide within the tumor was noted only in Warthin's tumors, but it was noted at the periphery of the tumors in 21 of the 24 cases (87.5%), which might be due to inflammation and/or compression of the gland by the tumors. Salivary gland scintigraphy provided useful information for the evaluation of the site of the tumor and the function of the salivary gland

  4. Primary Pulmonary Salivary Gland-type Tumors: A Review and Update.

    Falk, Nadja; Weissferdt, Annikka; Kalhor, Neda; Moran, Cesar A

    2016-01-01

    Pulmonary salivary gland-type tumors (SGT) comprise a very small proportion of primary lung neoplasms. The most common tumors among this group are mucoepidermoid carcinoma and adenoid cystic carcinoma. Contrary to the head and neck region, benign SGT such as pleomorphic adenomas are exceedingly rare in the pulmonary system. More recently, 2 additional SGT, namely hyalinizing clear cell carcinoma and salivary duct-like carcinoma were recognized as primary lung tumors expanding the spectrum of SGT that have been described to originate in the tracheobronchial system. Primary pulmonary SGT must be clinically excluded from metastatic salivary gland neoplasms as their morphology is indistinguishable from that of their salivary gland counterparts. Little is known about the clinical behavior and best treatment approach for these unusual tumors. In this review, we provide a comprehensive summary of primary pulmonary SGT with particular emphasis on morphologic characteristics and latest developments in terms of immunohistochemical and molecular techniques. PMID:26645458

  5. Remote afterloading high dose-rate intracavity radiotherapy for advanced maxillary cancer. Treatment with individual appliances

    Seven advanced maxillary cancers, 5 squamous cell carcinomas, and 2 adenoid cystic carcinomas were treated with remote afterloading high dose-rate intracavity radiotherapy. For treatment, we fabricated individual dental acrylic appliances for the postoperative area of the oral cavity. Because the appliance was specially matched to the remaining maxillary structures, radiation doses to the treated area were easily reproduced without distress to the patient. However, minor or major complications (moderate or severe mucositis and osteoradionecrosis) were observed in all patients. In this study, the number of patients was too small to assess the significance of this treatment. Nevertheless, with improvements, we think that remote afterloading high dose-rate intracavity radiotherapy with a dental acrylic appliance will soon be used to treat advanced maxillary carcinoma. (author)

  6. Management of difficult airway in intratracheal tumor surgery

    Agarwal Surendra K

    2005-06-01

    Full Text Available Abstract Background Tracheal malignancies are usual victim of delay in diagnosis by virtue of their symptoms resembling asthma. Sometimes delayed diagnosis may lead to almost total airway obstruction. For difficult airways, not leaving any possibility of manipulation into neck region or endoscopic intervention, femorofemoral cardiopulmonary bypass can be a promising approach. Case Presentation We are presenting a case of tracheal adenoid cystic carcinoma (cylindroma occupying about 90% of the tracheal lumen. It was successfully managed by surgical excision of mass by sternotomy and tracheotomy under femorofemoral cardiopulmonary bypass (CPB. Conclusion Any patient with recurrent respiratory symptoms should be evaluated by radiological and endoscopic means earlier to avoid delay in diagnosis of such conditions. Femorofemoral cardiopulmonary bypass is a relatively safe way of managing certain airway obstructions.

  7. [Possible pathogenesis of swimming sinusitis].

    Deitmer, T; Scheffler, R

    1990-04-01

    To investigate the pathogenesis of swimmer's sinusitis, a group of 20 swimmers and 20 controls were interviewed and examined. Clinical examination was followed by rhinomanometry, sonography of the maxillary sinuses, a saccharin test to assess mucociliary transport in the nose, and a viable cytological sampling of the nasal mucosa. Anamnesis showed a preponderance of symptoms of sinusitis and chronic rhinitis in the swimmer group, as well as a reddening of the nasal mucosa and a swelling of the adenoids. Sonography showed mucosal thickening in the antrum in more cases among the swimmers. Rhinomanometry, the saccharin test, and viable cytological sampling revealed no significant differences between the groups. It is argued that pathogenesis is more probable through cooling of the skin of the face and the whole body than through entrance of water into the upper respiratory tract. PMID:2354017

  8. Oral tumours seen at Korle Bu Teaching Hospital: a preliminary report

    Oral tumours in patients attending the oral Surgery Department of the Korle Bu Teaching Hospital, Accra, during a 12 month period from February 1998 to January 1999 were studied and classified. In all, 50 patients were included in the study out of which 33 were fully characterised and classified historically. Fifteen (45.4%) of the tumours examined were squamous cell carcinoma (SCC), 6(18.2%) ameloblastoma (AME), 3 (9.1%) each of Lympoma (L), adenoid cystic carcinoma (ADC) and pleomorphic adenoma (PA), 2(61.1%) ossifying fibroma (OF) and 1(3.0%) embryonal rhabdomyosar coma (ER). There was significant observed between the prevalence rates in men and women. OSCC was found to occur more frequently in the palate/maxillary sinus and the parotid gland whilst ameloblastoma was the commonest benign neoplasm within the fourth decade. (author)

  9. Retrievable Airway Stent Placement for Stoma Stricture after Anterior Mediastinal Tracheostomy: Case Report

    Anterior mediastinal tracheostomy (AMT) is performed to establish an airway after resection of advanced tumors in the cervicothoracic region. We report a case of successful placement of a covered retrievable self-expandable nitinol stent for a stoma stricture that developed after AMT in a patient with adenoid cystic carcinoma of the trachea. Two stent placements and removals, at two and three months after their initial placement, were performed due to loosening of the stents. Although we did not achieve long-term results as the patient died of massive hemorrhage, the stent placement was both feasible and safe, thus suggesting that temporary stent placement may be a valuable option for treating stoma stricture occurring after AMT.

  10. Retrievable Airway Stent Placement for Stoma Stricture after Anterior Mediastinal Tracheostomy: Case Report

    Hwang, Jae Yeon; Shin, Ji Hoon; Kim, Yong Hee; Song, Ho Young; Kim, Jin Hyoung [Dept. of University of Ulsan College of Medicine, Asan Medical Center, Seoul (Korea, Republic of); Lee, Yeoun Joo [Dept. of Pediatrics, Pusan National University Children' s Hospital, Yangsan (Korea, Republic of)

    2013-06-15

    Anterior mediastinal tracheostomy (AMT) is performed to establish an airway after resection of advanced tumors in the cervicothoracic region. We report a case of successful placement of a covered retrievable self-expandable nitinol stent for a stoma stricture that developed after AMT in a patient with adenoid cystic carcinoma of the trachea. Two stent placements and removals, at two and three months after their initial placement, were performed due to loosening of the stents. Although we did not achieve long-term results as the patient died of massive hemorrhage, the stent placement was both feasible and safe, thus suggesting that temporary stent placement may be a valuable option for treating stoma stricture occurring after AMT.

  11. Management of a case of left tracheal sleeve pneumonectomy under cardiopulmonary bypass: Anesthesia perspectives

    Aman Jyoti

    2014-01-01

    Full Text Available The lung tumors with carinal involvement are frequently managed with tracheal sleeve pneumonectomy and tracheobronchial anastomosis without use of cardiopulmonary bypass (CPB. Various modes of ventilation have been described during tracheal resection and anastomosis. Use of CPB during this period allows the procedure to be conducted in a more controlled way. We performed tracheal sleeve pneumonectomy for adenoid cystic carcinoma of left lung involving carina. The surgery was performed in two stages. In the first stage, left pneumonectomy was performed and in the second stage after 48 h, tracheobronchial resection and anastomosis was performed under CPB. Second stage was delayed to avoid excessive bleeding (due to heparinization from the extensive vascular raw area left after pneumonectomy. Meticulous peri-operative planning and optimal post-operative care helped in successful management of a complex case, which is associated with high morbidity and mortality.

  12. Childhood Obstructive Sleep Apnea

    R Dayal

    2014-03-01

    Full Text Available Obstructive sleep apnea (OSA is a common condition in childhood and can result insevere complications if left untreated. It is showing a rising trend in India. A significantassociation with obesity has been observed; however, some children with enlargedtonsils and/or adenoids may even be underweight. The patient usually presents withsnoring and other respiratory problems like mouth breathing, choking and gaspingepisodes in night. Poor school performance and neurocognitive deficits have beenreported. Pulmonary hypertension and cor pulmonale are seen in severe cases. Besidesthe history and clinical examination, for definitive diagnosis an overnightpolysomnographic evaluation is the gold standard. In all cases, the specific treatmentranges from simple lifestyle modifications and medications to surgeries likeadenotonsillectomy. Early diagnosis is vital.Key words: Childhood OSA, Obesity, adenotonsillar hypertrophy

  13. A case of presumed radiation optic neuropathy

    A case of a 37-year-old woman with radiation optic neuropathy was reported. She had undergone subtotal removal of the right orbital tumor (adenoid cystic carcinoma) by frontal craniotomy, followed by radiation therapy (64 Gy). She had been quite well until she noticed a gradual loss of vision in her right eye 18 months later. Her visual acuity was 0.2 in the right eye and 1.5 in the left eye with right relative afferent pupillary defect and dense central scotoma. Funduscopy revealed optic disc swelling with surrounding retinal edema and small hemorrhage in the right eye. Fluorescein angiography revealed a hypoperfusion area and obstruction of the small retinal vessels in the posterior pole, but this was not large enough to explain the dense central scotoma. Although prednisolone therapy gave temporary improvement, the visual function gradually deteriorated. (author)

  14. Decellularized porcine derived membrane (Tarsys®) for correction of lower eyelid retraction.

    Borrelli, Maria; Unterlauft, Jan; Kleinsasser, Norbert; Geerling, Gerd

    2012-06-01

    Retraction of the lower eyelid can be consequence of medical and surgical conditions. Various kinds of allotransplants and biomaterial have been used to correct it; we report on the surgical correction of lower lid retraction with a decellularized porcine derived membrane (Tarsys(®)). A 49-year-old patient with a history of adenoid cystic carcinoma in the pterygo-palatine fossa, requiring extensive surgery and repeated radiotherapy, presented with 6 mm lagophthalmus and exposure keratopathy secondary to facial nerve palsy. The lower lid malposition was corrected with a Tarsys(®) implant. Three months after surgery no lagophthalmos was present and substantial relief of signs and symptoms of ocular surface disease and good symmetry between right and left eye was achieved. If general condition or morbidity in potential donor sites hamper harvesting autologous graft material to support the lower lid, bioengineered xenografts can be used successfully to correct eyelid malpositions such as lower lid retraction. PMID:22551374

  15. A rare cause of respiratory distress in newborn: posterior mediastinal gastroenteric cyst - Case Report

    Erdal Ta?k?n

    2011-03-01

    Full Text Available Presentation of mediastinal enteric cysts are rare during neonatal period. They are mostly asymptomatic. The commonest mode of presentation in neonatal period is repiratory distress. Basically, diagnosis of enteric cyst is histologically, for all that vertebral anomalies associated with posterior mediastinal cyst is property of enteric cyst. 0-24h male patient who diagnosed cystic adenoid malformation of lung on prenatal ultrasonographic examination developed respiratory distress at day 4 of life after birth. Investigations revealed a well defined gastroenteric cyst in the posterior mediastinum with vertebral anomalies. The purpose of this case report is to highlight the clinical diagnosis and management of a neonate with posterior mediastinal enteric cyst. (Turk Arch Ped 2011; 46: 90-2

  16. Treatment Options for Pediatric Obstructive Sleep Apnea.

    Cielo, Christopher M; Gungor, Anil

    2016-01-01

    There are a variety of therapies available for the treatment of pediatric obstructive sleep apnea syndrome (OSAS). In children with enlarged adenoids or tonsils, adenotonsillectomy (AT) is the preferred treatment, but other surgical options include partial tonsillectomy and lingual tonsillectomy. In specific populations, craniofacial or bariatric surgery may be indicated, and tracheostomy should be reserved for cases where there is no other therapeutic option. Positive airway pressure (PAP) is the most effective non-surgical therapy for OSAS as it can be successfully used in even cases of severe OSAS. Nasal steroids and leukotriene receptor antagonists may be used in the treatment of mild or moderate OSAS. Rapid maxillary expansion and dental appliances may be effective in select populations with dental problems. Other non-surgical therapies, such as positional therapy, supplemental oxygen, and weight loss have not been shown to be effective in most pediatric populations. PMID:26597557

  17. Characteristic Formation of Hyaluronan-Cartilage Link Protein-Proteoglycan Complex in Salivary Gland Tumors.

    Kuwabara, Hiroko; Nishikado, Akira; Hayasaki, Hana; Isogai, Zenzo; Yoneda, Masahiko; Kawata, Ryo; Hirose, Yoshinobu

    2016-01-01

    Hyaluronan (HA) and its binding molecules, cartilage link protein (LP) and proteoglycan (PG), are structural components of the hydrated extracellular matrix. Because these molecules play important roles in the tumor microenvironment, we examined the distribution of HA, LP, versican, and aggrecan in salivary gland tumors using histochemical and immunohistochemical methods, including double staining. LP was present in pleomorphic adenoma (PA) and adenoid cystic carcinoma (ACC) tissues, and aggrecan was absent in the malignant tumors that we investigated. LP colocalized with both HA and aggrecan in the chondromyxoid matrix of PA, suggesting the presence of a HA-LP-aggrecan complex. Furthermore, the HA-LP-versican complex could be observed in the pseudocystic space of the cribriform structures in ACC. The characteristic HA-LP-PG complex in PA and ACC might play a role in the behavior of tumors, and immunohistochemical analysis of these molecules could represent a diagnostic adjunct for salivary gland tumors. PMID:26067139

  18. Thyroid and associated polyglandular neoplasms in patients who received head and neck irradiation during childhood

    One hundred fifty-one patients with a history of childhood irradiation to the head, neck, and thorax had neck explorations (142 for cold thyroid nodules and 9 for hypercalcemia). Fifty-nine of the patients had thyroid carcinoma, and associated glandular tumors were found in 20 others. In addition, 6 female patients developed breast carcinoma; 4 of these women also had thyroid carcinoma. In this series, 48.6% of the patients irradiated for acne and 36.4% with tonsil and adenoid irradiation developed thyroid carcinoma, but only 10.5% with thymic irradiation did so. It is suggested that the workup on these patients include not only complete thyroid and parathyroid testing, but also a careful examination of all salivary glands, both major and minor. Women should have thorough breast examinations and should perhaps be followed as if they were in the potentially high-risk breast group. When thyroid surgery is performed, a total thyroidectomy is recommended

  19. Incidentally found and unexpected tumors discovered by MRI examination for temporomandibular joint arthrosis

    We examined the frequency of incidentally found or unexpected tumors discovered at the time of magnetic resonance imaging (MRI) examinations in the temporomandibular joint (TMJ) region for patients with suspicion of TMJ arthrosis. Five MR images (T1-weighted transverse scout image and proton density and T2-weighted oblique sagittal images at the open and closed mouth) were acquired. In 2776 MRI examinations of TMJ arthrosis, two tumors were discovered. They consisted of an adenoid cystic carcinoma in the deep portion of the parotid gland, and a malignant tumor extending from the infratemporal fossa to the parapharyngeal space. The rate of incidentally founded or unexpected tumors in TMJ examinations was low (0.072%), but the two tumors found were malignant tumors, and therefore, scout image should be carefully examined, not only used for positing the slice

  20. Radiographic anatomy and pathology of the child's airway

    The laryngotracheal airway has been considered the ''bottle-neck'' of the lungs. Any compromise of this already rather small pathway can easily result in a life-threatening situation. Rapid, accurate diagnosis is essential for proper clinical management of a compromised airway. Radiologic studies play a major role in the clinical investigation of patients with serious airway problems. There are notable differences between the anatomy of the upper airway of the adult and that of the young child or infant. In the infant, however, some differences in the radiographic patterns must be kept in mind. In the first 6 months of life, the adenoid shadow is not well defined and is normally absent until 1 month of age. During swallowing there is a lack of air in the pharynx with elevation of the larynx. Air may be seen in the cervical esophagus. All of these physiologic variations must be considered when interpreting radiographs of the neck in the young child

  1. Clinicopathological analysis of salivary gland tumors over a 15-year period

    Artur Cunha VASCONCELOS

    2016-01-01

    Full Text Available Abstract Salivary gland tumors (SGT are rare neoplasms that generate interest due to their histopathological diversity and clinical behavior. The aims of the present study were to investigate clinicopathological aspects of SGTs diagnosed at a tertiary health center and compare the findings with epidemiological data from different geographic locations. Cases of tumor in the head and neck region at a single health center in the period between 1995 and 2010 were reviewed. Patient gender, age and ethnic group as well as anatomic location, histological type and clinical behavior of the tumor were recorded. Availability of complete information about these aspects was considered the inclusion criteria. Descriptive statistical analysis of the data was performed using the frequencies of categorical variables. Among the 2168 cases of tumors in the head and neck region, 243 (11.20% cases were diagnosed in the salivary glands, 109 of which met the inclusion criteria: 85 (78% benign tumors and 24 (22% malignant tumors. Mean patient age was 46.47 years. The female gender accounted for 56 cases (51.4% and the male gender accounted for 53 (48.3%. The major salivary glands were affected more (75.2% than the minor glands. The most frequent benign and malignant SGTs were pleomorphic adenoma (81.2% and adenoid cystic carcinoma (58.3%, respectively. In conclusion, pleomorphic adenoma and adenoid cystic carcinoma are the most frequent benign and malignant lesions, respectively. Comparing the present data with previous studies on SGTs, one may infer that some demographic characteristics and the predominance of malignant tumors vary in different geographic regions.

  2. Differential expression of topoisomerase IIα protein in salivary gland carcinomas: histogenetic and prognostic implications

    Salivary gland carcinomas are relatively uncommon heterogeneous malignancies characterized by locoregional invasion and distant metastasis. Topoisomerase IIα (topoIIα), located at chromosome 17q21-22, is considered a major mediator of cell proliferation and DNA replication. The purpose of this study was to evaluate the expression of topoIIα in various types of salivary gland tumors and its biological significance. The protein expression of topoIIα was evaluated immunohistochemically in formalin-fixed, paraffin-embedded tissue from 54 salivary gland carcinomas and 20 benign tumors (10 pleomorphic adenomas and 10 Warthin's tumors). The primary salivary gland carcinoma specimens consisted of 17 adenoid cystic carcinomas, 7 adenocarcinomas not otherwise specified, 7 mucoepidermoid carcinomas, 6 salivary duct carcinomas, 3 acinic cell carcinomas, 3 carcinomas ex pleomorphic adenomas, 3 epithelial-myoepithelial carcinomas, 2 carcinosarcomas, 2 lymphoepithelial carcinomas, 2 myoepithelial carcinomas, 1 oncocytic carcinoma, and 1 squamous cell carcinoma. The associations between clinicopathological factors and outcome were analyzed. Of the 54 primary salivary gland carcinomas, 38 (70%) showed positive expression (≥10%) of topoIIα protein, and 16 carcinomas (30%) and all benign tumors were negative (p < 0.001). Expression of topoIIα was more frequently observed in salivary duct carcinoma, carcinoma ex pleomorphic adenoma, adenocarcinoma, and adenoid cystic carcinoma, solid type, and it was associated with advanced stage and shortened survival. The results of the present study suggest that topoIIα expression is associated with histologically aggressive subtypes and shortened survival. Furthermore, it may provide useful prognostic information and suggests the potential efficacy of topoIIα-targeting therapy in patients with salivary gland carcinoma

  3. MRI analysis on soft tissue around upper airway in obese adolescent patients with obstructive sleep apnea syndrome

    Objective: To investigate the correlation of soft tissue structure of upper airway with the pathogenesis of obstructive sleep apnea syndrome (OSAS) in adolescents age group by analyzing magnetic resonance imaging (MRI) of upper airway. Methods: The subjects were divided into obese OSAS, obese controls and normal weight controls groups according to the results from polysomnography and body mass index measurements; Upper airway was scanned by MRI sagittally and axially; upper airway at all levels and soft tissue was analyzed by Amira Medical image analysis system. Results: Tongue volumes in obese OSAS and obese controls were significantly greater than that in normal weight controls (P<0.05); tonsil and adenoid volumes in obese OSAS were significantly higher than those in two control groups (P<0.05 or P<0.001), but no significant difference was found between two control groups. The volumes of lateral pharyngeal wall in obese OSAS were higher than those in obese controls and normal weight controls (P<0.05 or P<0.001), and they were higher in obese controls compared with normal weight controls (P<0.05). In obese OSAS group, positive correlations were found between volumes of lateral pharyngeal wall and apnea/hypopnea index (AHI) (r=0.879, P<0.01), as well volumes of tonsils and AHI (r=0.824, P<0.01). Conclusion: Obesity can increase the soft tissue volumes around upper airway, there by increase the upper airway obstruction; lateral pharyngeal wall and adenoid volumes play major roles in evaluating the severity of OSAS in adolescents. (authors)

  4. Potential pitfalls in MitoChip detected tumor-specific somatic mutations: a call for caution when interpreting patient data

    Several investigators have employed high throughput mitochondrial sequencing array (MitoChip) in clinical studies to search mtDNA for markers linked to cancers. In consequence, a host of somatic mtDNA mutations have been identified as linked to different types of cancers. However, closer examination of these data show that there are a number of potential pitfalls in the detection tumor-specific somatic mutations in clinical case studies, thus urging caution in the interpretation of mtDNA data to the patients. This study examined mitochondrial sequence variants demonstrated in cancer patients, and assessed the reliability of using detected patterns of polymorphisms in the early diagnosis of cancer. Published entire mitochondrial genomes from head and neck, adenoid cystic carcinoma, sessile serrated adenoma, and lung primary tumor from clinical patients were examined in a phylogenetic context and compared with known, naturally occurring mutations which characterize different populations. The phylogenetic linkage analysis of whole arrays of mtDNA mutations from patient cancerous and non-cancerous tissue confirmed that artificial recombination events occurred in studies of head and neck, adenoid cystic carcinoma, sessile serrated adenoma, and lung primary tumor. Our phylogenetic analysis of these tumor and control leukocyte mtDNA haplotype sequences shows clear cut evidence of mixed ancestries found in single individuals. Our study makes two prescriptions: both in the clinical situation and in research 1. more care should be taken in maintaining sample identity and 2. analysis should always be undertaken with respect to all the data available and within an evolutionary framework to eliminate artifacts and mix-ups

  5. Clinicopathological analysis of salivary gland tumors over a 15-year period.

    Vasconcelos, Artur Cunha; Nör, Felipe; Meurer, Luise; Salvadori, Gabriela; de Souza, Lélia Batista; Vargas, Pablo Agustin; Martins, Manoela Domingues

    2016-01-01

    Salivary gland tumors (SGT) are rare neoplasms that generate interest due to their histopathological diversity and clinical behavior. The aims of the present study were to investigate clinicopathological aspects of SGTs diagnosed at a tertiary health center and compare the findings with epidemiological data from different geographic locations. Cases of tumor in the head and neck region at a single health center in the period between 1995 and 2010 were reviewed. Patient gender, age and ethnic group as well as anatomic location, histological type and clinical behavior of the tumor were recorded. Availability of complete information about these aspects was considered the inclusion criteria. Descriptive statistical analysis of the data was performed using the frequencies of categorical variables. Among the 2168 cases of tumors in the head and neck region, 243 (11.20%) cases were diagnosed in the salivary glands, 109 of which met the inclusion criteria: 85 (78%) benign tumors and 24 (22%) malignant tumors. Mean patient age was 46.47 years. The female gender accounted for 56 cases (51.4%) and the male gender accounted for 53 (48.3%). The major salivary glands were affected more (75.2%) than the minor glands. The most frequent benign and malignant SGTs were pleomorphic adenoma (81.2%) and adenoid cystic carcinoma (58.3%), respectively. In conclusion, pleomorphic adenoma and adenoid cystic carcinoma are the most frequent benign and malignant lesions, respectively. Comparing the present data with previous studies on SGTs, one may infer that some demographic characteristics and the predominance of malignant tumors vary in different geographic regions. PMID:26676198

  6. An overview of Bcl-2 expression in histopathological variants of basal cell carcinoma, squamous cell carcinoma, actinic keratosis and seborrheic keratosis.

    Puizina-Ivić, Neira; Sapunar, Damir; Marasović, Dujomir; Mirić, Lina

    2008-10-01

    The Bcl-2 protein has been shown to suppress cell death and protects cell against apoptosis induced by different death-inducing signals. In this study the authors have analyzed imunohistochemically the expression of Bcl-2 protein in the histopathological variants of the most common malignant tumors of the skin--basal cell carcinoma (BCC) and squamous cell tumor (SCC), as well as in the precancerous lesion actinic keratosis (AK) and in benign tumor seborrheic keratosis (SK). Bcl-2 expression in solid, adenoid and cystic variants of BCC exhibited immunoreactivity of tumor stroma with more intense staining among peripheral palisading cells. Morphoeic variant demonstrated reduced amount of Bcl-2 expression. Among SCC in all samples, tumor tissue lack to express Bcl-2 positivity. In cases of hypertrophic and atrophic variants of AK, Bcl-2 expression was confined to basal cell layer, as well as in one case of hypertrophic variant in suprabasal cells. In three histological variants of SK expresseion of Bcl-2 protein was in areas of basaloid proliferation, while in areas of squamous differentiation was negative. In clonal variant immunostaining was positive among cells in characteristic "nests" Distribution of Bcl-2 protein expression in solid, adenoid and cystic variant of BCC showed that peripheral proliferating cells are protected against apoptosis what permits tumor growth. In morpheaform variant reduced amount of Bcl-2 expression indicated that this variant of BCC has increased cell proliferation, and in practice shows tendency for recurrence and difficulties to eradicate. Bcl-2 expression supports the observation that tumor cells are derived from basal keratinocytes. In SCC, lack of Bcl-2 expression indicates that origin of tumor cells is from more differentiated suprabasal keratinocytes. In AK results suggest that immunoreactivity is regulated with respect of the keratinocyte's differentiation status, but not closely correlate with proliferative rate. PMID:19138009

  7. Kystes de l'ovaire: score échographique de malignité

    Dimassi, Kaouther; Bettaieb, Hajeur; Derbel, Mohammed; Triki, Amel; Gara, Mohammed Faouzi

    2014-01-01

    Les kystes de l'ovaire constituent l'un des motifs les plus fréquents de consultation en gynécologie. L’étape diagnostique repose principalement sur l’échographie. Nous proposons dans ce travail un score échographique reproductible prédictif de malignité. Nous évaluons la fiabilité de ce score après confrontations des données échographiques et histologiques. Il s'agit d'une étude rétrospective réalisée sur une période de 3 ans. Nous avons élaboré un score basé sur les signes échographiques décrits dans la littérature comme prédictifs de malignité et avons classé les examens échographiques préopératoires selon leurs scores respectifs. Les données échographiques étaient comparées aux résultats histologiques et un seuil prédictif de malignité a été déterminé pour le score adopté. 150 patientes ont été colligées. Les deux signes échographiques les plus prédictifs de malignité étaient: les végétations endo-kystiques, avec une Valeur Prédictive Positive (VPP) à 86,67% et une Valeur Prédictive Négative (VPN) à 100%, et le caractère vascularisé au Doppler couleur avec une VPP à 72,52% et une VPN à 100%. Le seuil retenu pour le score proposé était de 6 avec une spécificité de 100%, une sensibilité de 100%, une VPP de 100% et une VPN de 100%. L’échographie joue un rôle décisif dans la conduite à tenir devant une masse ovarienne. Seul un faisceau d'arguments permet d’évoquer la malignité lors de l'examen échographique. L'utilisation de scores basés sur des signes simples, reproductibles augmente la valeur diagnostique de l’échographie en matière de malignité. PMID:25419341

  8. Tumeurs rares de l'ovaire: à propos d'une série de 11 cas de tumeurs non épithéliales malignes de l'ovaire

    Mamouni, Nisrine; Saadi, Hanane; Erraghay, Sanaa; Bouchikhi, Chahrazade; Banani, Abdelaziz

    2015-01-01

    Les tumeurs non épithéliales malignes de l'ovaire représentent environ 20% des cancers de l'ovaire. L'objectif de notre travail est de dresser les particularités diagnostiques cliniques et d'imagerie de ces tumeurs. Nous avons procédé à une étude rétrospective portant sur 11 cas de tumeurs non épithéliales de l'ovaire. Ces tumeurs ont été colligées au service de gynécologie et obstétrique I du CHU Hassan II de Fès sur une période de 4 ans, entre janvier 2009 et décembre 2012. Les tumeurs germinales représentant 54% (6 patientes) des cas alors que les tumeurs du cordon sexuel ont été représentées par 4 cas de tumeurs de granulosa de type adulte et nous avons colligés un cas de lymphome ovarien primitif. La symptomatologie clinique était dominée par la distension abdominale associée souvent à des douleurs abdominopelviennes chroniques. La taille tumorale moyenne était de 175 mm avec un aspect solido-kystique dans 54% des cas. Le dosage des marqueurs tumoraux (hormone chorionique gonadotrope, lactate déshydrogénase, CA 125, alpha-fœtoprotéine) a été réalisé chez toutes les patientes. La découverte d'une masse annexielle suspecte chez une jeune femme doit, outre une tumeur frontière ou un cancer épithélial de l'ovaire, évoquer une tumeur non épithéliale, a fortiori si cette masse est volumineuse, si elle est associée à des signes d'hyperestrogénie ou d'androgénie. PMID:26113917

  9. Clinical and pathological evaluation of fibrolamellar hepatocellular carcinoma: a single center study of 21 cases

    Aline Lopes, Chagas; Luciana, Kikuchi; Paulo, Herman; Regiane S.S.M., Alencar; Claudia M., Tani; Mrcio Augusto, Diniz; Vincenzo, Pugliese; Manoel de Souza, Rocha; Luiz Augusto Carneiro, D& #8242; Albuquerque; Flair Jose, Carrilho; Venancio A.F., Alves.

    2015-03-01

    Full Text Available OBJECTIVES: Fibrolamellar hepatocellular carcinoma is a rare primary malignant liver tumor that differs from conventional hepatocellular carcinoma in several aspects. The aim of this study was to describe the clinical, surgical and histopathological features of fibrolamellar hepatocellular carcinom [...] a and to analyze the factors associated with survival. METHODS: We identified 21 patients with histopathologically diagnosed fibrolamellar hepatocellular carcinoma over a 22-year period. Clinical information was collected from medical records and biopsies, and surgical specimens were reviewed. RESULTS: The median age at diagnosis was 20 years. Most patients were female (67%) and did not have associated chronic liver disease. Most patients had a single nodule, and the median tumor size was 120 mm. Vascular invasion was present in 31% of patients, and extra-hepatic metastases were present in 53%. Fourteen patients underwent surgery as the first-line therapy, three received chemotherapy, and four received palliative care. Eighteen patients had pure fibrolamellar hepatocellular carcinoma, whereas three had a distinct area of conventional hepatocellular carcinoma and were classified as having mixed fibrolamellar hepatocellular carcinoma. The median overall survival was 36 months. The presence of mixed fibrolamellar hepatocellular carcinoma and macrovascular invasion were predictors of poor survival. Vascular invasion was associated with an increased risk of recurrence in patients who underwent surgery. CONCLUSION: Fibrolamellar hepatocellular carcinoma was more common in young female patients without chronic liver disease. Surgery was the first therapeutic option to achieve disease control, even in advanced cases. Vascular invasion was a risk factor for tumor recurrence. The presence of macrovascular invasion and areas of conventional hepatocellular carcinoma were directly related to poor survival.

  10. BOWEN’S DISEASE IN LEG - A RARE OCCURRENCE

    Gowri Sankar

    2014-02-01

    Full Text Available ar old female presented with complaints of asymptomatic , raised skin lesion over left leg for the past two years , which on local examination revealed a single , localized , well defined , rounded plaque of 4 cm . Clinically Bowen’s disease was not suspected because of its rarity and also occurred in the unusual site . Biopsy was taken and sent for histo - pathological examination . In histo - pathological examination Bowen’s disease was diagnosed . This case is highlighted to show the pathologist’s help in making a proper diagnosis when atypical skin lesions are seen at unusual sites . INTRODUCTION : Most of the overt malignant conditions actually originate as microscopic lesions , which are designated as in - situ carcinomas . These in - situ carcinomas are typically notic ed as intra - epithelial lesions , most often seen in squamous cell epithelial lined tissue eg . oral mucosa , genitals , cervix and skin . In skin , the intra - epithelial carcinoma - in situ lesions may be Bowen’s disease , Bowenoid papulosis or Erythroplasia of Queyrat . In the same way gastrointestinal and urinary system also can show in - situ malignancies . Bowen’s disease was first described by an American dermatologist John T Bowen in the year 1912 . It is most commonly reported in sun exposed sites . It rarely oc curs in patients with darkly pigmented skin . Bowen’s disease is observed in skin and external genitals and is sometimes associated with arsenic poisoning and visceral carcinomas . Bowen’s disease is a rare , persistent , progressive , intra - epithelial carcinom a , 8% of which will develop into an invasive squamous cell carcinoma . Treat

  11. Impact of thawing on reference gene expression stability in renal cell carcinoma samples.

    Ma, Yi; Dai, HuiLi; Kong, XianMing; Wang, LiMin

    2012-09-01

    More and more samples are obtained from biobanks for biomedical research; however, some of these samples may undergo thawing before processing. We aim to evaluate the reference gene expression stability in thawed renal cell carcinoma samples. Sixteen matched malignant and nonmalignant renal tissue samples were obtained and each sample was divided into 4 aliquots before being snap frozen and stored at -80°C. By quantitative real-time polymerase chain reaction, a time-course study was conducted on the thawed tissue to evaluate the expression stability of a panel of the 10 most frequently used reference genes in renal cell carcinom samples: ACTB, ALAS1, B2M, GAPDH, HMBS, HPRT, PPIA, RPLP0,TBP, and TUBB. As shown by geNorm M values, PPIA was the most stable gene at the 0-, 15-, and 30-minute time points (M=0.82, 0.85, and 0.76, respectively), whereas GAPDH was ranked last at the 5-, 15-, and 30-minute time points (M=1.38, 1.44, and 1.39, respectively). A positive correlation was found by linear regression between the thawing time and 2 to the power of crossing point values of all candidate reference genes (P<0.05). The mean coefficient of variance of all reference genes increased significantly at time points 5, 15, and 30 minutes compared with 0 minutes (P<0.01). In conclusion, using the geNorm algorithm, PPIA was identified as the most stably expressed gene between malignant and nonmalignant renal tissue samples that were thawed for similar time periods. All the reference genes showed high variations along with the thawing time; it should be recommended to use a combination of several candidate reference genes when comparing samples thawed for different time periods. PMID:22847160

  12. Intensive cyclophosphamide (NSC-26271) therapy for solid tumors.

    Mullins, G M; Colvin, M

    1975-01-01

    Cyclophospamide was given in two dose schedules to 25 patients with a variety of nonlymphoid solid tumors. Eleven patients were given 18 courses of cyclophosphamide at a total dose of 60 mg/kg. Sixteen patients received 26 courses at a total dose of 100 mg/kg. Two patients were treated with both regimens. Partial responses were achieved in two patients treated with 60-mg/kg dose of cyclophosphamide. One of these patients had osteogenic sarcoma and the other had renal carcinoma. The higher dose also produced two partial responses, one in a patient with anaplastic carcinom a of the lung and the other in a patient with anaplastic carcinoma of the lung and the other in a patient with embryonal testicular carcinoma. Mean leukocyte counts fell to a nadir of 1400 cells/mm after 60 mg/kg while they dropped to below 1000 cells/mm for 5 days after 100 mg/kg of cyclophosphamide. Mean platelet counts remained above 150,000 platelets/mm after both cyclophosphamide schedules. In fective complications were documented aftter three of the 18 courses at 60 mg/kg and after ten of the 26 courses at 100 mg5kg. In the latter group, there were three episodes of bacteremia, including one death from pseudomonas sepsis. Nonhematologic toxicity noted with the 100-mg/kg dose of cyclophosphamide included rare instances of electrocardiogram changes and serum enzyme alterations compatible with myocardial toxicity. The intensive cyclophosphamide therapy did not appear to result in an increased antitumor response in malignancies usually considered to be refractory to alkylating agents. PMID:1097100

  13. Immunohistochemical expression of basement membrane laminin in histological grades of oral squamous cell carcinoma: A semiquantitative analysis

    R Shruthy

    2013-01-01

    Full Text Available Background and Objectives: To determine the immunohistochemical (IHC localization of basement membrane component laminin in histological grades of oral squamous cell carcinoma (OSCC. The purpose of this study was to demonstrate the loss of continuity of the basement membrane in OSCC using an antibody directed against laminin using advanced polymer staining system. Materials and Methods: A total of 30 cases of OSCC: 10 cases of well differentiated squamous cell carcinom (WDSCC, 10 cases of moderately differentiated squamous cell carcinoma (MDSCC, and 10 cases of poorly differentiated squamous cell carcinoma (PDSCC were subjected to heat-induced antigen retrieval method using ethylene-di-amine-tetraacetic acid buffer in a microwave oven. Then the sections were stained with anti-laminin polyclonal antibody and visualized using super sensitive polymer horseradish peroxidase detection system. In each case, the integrity of the basement membrane laminin was assessed by using statistical analysis. Results: Statistical analysis showed a decreased distribution of laminin from WDSCC to MDSCC to PDSCC (P value 0.0573. The intracytoplasmic staining of laminin gradually increased from WDSCC to MDSCC to PDSCC (P value 0.0198. Interpretation and Conclusion: WDSCC cases showed more laminin expression in basement membrane around the tumor islands and less loss of continuity compared to MDSCC and PDSCC cases suggesting a greater enzymatic degradation of basement membrane components in MDSCC and PDSCC than WDSCC. The loss of structural basement membrane laminin and the presence of laminin in the tumor cells of PDSCC cases suggest that laminin helps in tumor invasion. The expression of laminin in the basement membrane may be a useful parameter to evaluate tumor histologic differentiation and aggressiveness.

  14. Thyrodectomies pratiques sous anesthsie locale au Centre Hospitalier Universitaire d'Antananarivo

    Razafindrakoto, Rex Mario; Razafindranaivo, Mananjara Nandrianina; Valisoa, Herimalalaniaina Angelo; Schammirah, Mahamad Rojovolaarivony; Randriamboavonjy, Rado

    2015-01-01

    Mene le plus souvent sous anesthsie gnrale, la chirurgie thyrodienne peut aussi tre pratique sous anesthsie rgionale ou sous anesthsie locale. Notre objectif a t de rapporter l'exprience du Centre Hospitalier Universitaire d'Antananarivo sur l'anesthsie locale dans les thyrodectomies. La drogue employe dans notre protocole anesthsique a t le fentanyl, administr en intraveineuse directe, associ une infiltration sous-cutane de lidocane suivant la ligne d'incision. Le/la patient(e) n'a pas t intub(e), l'oxygne tant dlivr au niveau des cavits nasales. Ont t tudis le type de chirurgie thyrodienne, la dure de l'intervention, la satisfaction des patient(e)s vis--vis de la qualit de l'anesthsie, et le cot de l'intervention. Sur 567 thyrodectomies effectues, 51,68% (n= 293) ont t des lobo-isthmectomies gauches, 44,44% (n= 252) des lobo-isthmectomies droites, 2,82% (n= 16) des thyrodectomies subtotales ou totales, 1,06% (n= six) des totalisations pour carcinomes thyrodiens. La dure des interventions a vari de 30 90 minutes. Un total de 83,95% (n= 476) des patient(e)s a t trs satisfait de la qualit de l'anesthsie et 15,87% autres (n= 90) satisfait. Les suites opratoires ont t bonnes dans la majorit des cas. Le cot d'une thyrodectomie a t valu 100- 150 dollars amricains. L'anesthsie locale utilise dans les thyrodectomies effectues au Centre Hospitalier Universitaire d'Antananarivo est simple, rapide, d'un cot moyen, et permet d'alarmer prcocement le chirurgien en cas de lsion d'un nerf laryng infrieur. PMID:26587128

  15. Initial results of irradiation for prostatic cancer following three-dimensional treatment planning. Irradiation technique and toxicity

    During the period from June 91 until May 93 thirty-three patients suffering from histologically confirmed carcinoms of the prostate were assigned to four treatment groups and subjected to irradiation of the prostate and, if required, efferent lymphatic system of the minor pelvis that was performed according to a three-dimensional prospective treatment plan. The doses used for localized radiotherapy of the tumour tissue were in the range between 62 and 70 Gy, the efferent lymph system of the minor pelvis was irradiated with doses of up to 50 Gy. The local or boost treatments were carried out using four (box technique) or five irregular fields, while radiotherapy of the minor pelvis was solely based on the box technique using four fields of irregular shape. The immediate and long-term toxicity was evaluated in a prospective approach according to the RTOG score for the rectum, urinary bladder and skin. Twenty-five of the thirty-three patients (76%) developed immediate toxic symptoms. Immediate reactions classifiable with degree II of the rating scale were, however, only observed in four patients (15%) for the rectum (2), bladder (1) and skin (1). Immediate toxic reactions compatible with RTOG grades III or IV were not recorded. In all patients, the untoward effects were completely reversed within a maximum period of 6 weeks following termination of treatment. Two patients from the study cohort (6%), which has so far been followed up for an average period of 16 months, showed long-term grade I effects in the rectum and a further long-term effect observed in the urinary bladder of another patient was classified with degree II. Two patients died intercurrently and two patients developed metastases remote from the primary tumour. Local tumour control can currently be reported for 96%. (orig.)

  16. Carcinoma adenoideo qustico de la mama: A propsito de un caso

    Luis Daro, Espinoza; Linerys, Len; Yris, Bravo Bello; Grace, Socorro.

    2010-06-01

    Full Text Available OBJETIVO: El carcinoma adenoideo qustico de la mama es inusual se presenta con una frecuencia menor al 1 %. La presentacin de este caso est relacionada con la rareza del mismo, incidencia de 0,1 %. MTODOS: Paciente femenina 56 aos de edad, menarqua: 15 aos. IIIG, IP, IC, IA. Menopausia: 2002. [...] No recibe terapia hormonal. No antecedentes personales y/o familiares de patologa mamaria. Consulta a nuestra unidad por control, examen fsico:normal. Mamografa:mamascon moderadacantidad de tejido fibroglandular, evidencia opacidad nodular en unin de cuadrantes inferiores mama derecha. Eco mamario: imagen aspecto slido bordes regulares, ubicada en cuadrantes inferiores de mama derecha de 6,1 mm x 7,1 mm x 7,0 mm, se corresponde con opacidad nodular mamogrfica. DISCUSIN: Evaluacin mastolgica clase IV. Se recomienda evaluacin histolgica de la lesin a travs de tcnica de biopsia ecoguiada. Anatoma patolgica: carcinoma adenoideo qustico. Grado nuclear II, actividad mittica atpica presente. Desmoplasia estromal severa. Estudio de inmunohistoqumica: CK7+ (clulassecretoras),CK7/CK14+(clulasadenoescamosas), colgeno tipo IV. Se realizamastectoma parcial oncolgica derecha, previa localizacin y confirmacin por imagen mrgenes por corte congelado ms ganglio centinela. Anatoma patolgica: carcinoma adenoideo qustico de 0,7 cm. Grado nuclear I. Actividad mittica atpica presente. Bordes de reseccin quirrgica, margen adicional libres de lesin. Patologa mamaria adicional: ectasia ductal y condicin fibroqustica. Ganglio linftico centinela uno sin evidencia de neoplasia. En marzo de 2009, paciente acude a control, donde se realiza evaluacin mastolgica concluyndose clase IIRF. Abstract in english OBJECTIVE: Adenoid cystic breast carcinoma is rare variant occurring less than 1 %. The presentation of this case is related to the rarity of it, because the incidence of this tumor in the breast is 0.1 %. METHOD: Female patient, 56 years old, menarche: 15 years. III pregnancy: IB, IP, IA. Menopause [...] : 2002. Not receiving substitutive hormone therapy. No personal and family history of breast pathology. She came in August, 2007 for breast evaluation, physicalexamination:Normal. Mammography:Breastwith moderate amount of fibroglandular tissue, nodular opacity in union of lower quadrants right breast. Breast ultrasound: Solid image, with regular edges, located at junction of lower quadrants right breast, measuring 6.1 mm x 7.1 mm x 7.0 mm, which corresponds with nodular mammographic opacity. DISCUSSION: Mast logical evaluation class IV. Histological evaluation of lesion, using the technique of microbiopsia ecoguide. Pathology report: Adenoid cystic carcinoma, nuclear grade II. This atypical mitotic activity, stromal desmoplasia severe. Immunohistochemistry: CK7 + (secretory cells), CK7/CK14 + (Adenosquamous cell), type IV collagen. Partial mastectomy was performed in oncology right after echolocate confirmation by imaging, margins cut more frozen sentinel node. With pathology report: Adenoid cystic carcinoma of 0.7 cm. nuclear grade I, atypical mitotic activity, edge of surgical resection and additional margin free of injury. Additional mammary pathology: Fibrocystic status, ductal ectasia. A sentinel lymph node without evidence of malignancy; March 2009, the patient comes to control,where assessment is completed mast logical class IIRF.

  17. Interleukin-12 and Trastuzumab in Treating Patients With Cancer That Has High Levels of HER2/Neu

    2013-02-27

    Advanced Adult Primary Liver Cancer; Anaplastic Thyroid Cancer; Bone Metastases; Carcinoma of the Appendix; Distal Urethral Cancer; Fallopian Tube Cancer; Gastrinoma; Glucagonoma; Inflammatory Breast Cancer; Insulinoma; Liver Metastases; Localized Unresectable Adult Primary Liver Cancer; Lung Metastases; Male Breast Cancer; Malignant Pericardial Effusion; Malignant Pleural Effusion; Metastatic Gastrointestinal Carcinoid Tumor; Metastatic Parathyroid Cancer; Metastatic Transitional Cell Cancer of the Renal Pelvis and Ureter; Newly Diagnosed Carcinoma of Unknown Primary; Occult Non-small Cell Lung Cancer; Pancreatic Polypeptide Tumor; Primary Peritoneal Cavity Cancer; Proximal Urethral Cancer; Pulmonary Carcinoid Tumor; Recurrent Adenoid Cystic Carcinoma of the Oral Cavity; Recurrent Adrenocortical Carcinoma; Recurrent Adult Primary Liver Cancer; Recurrent Anal Cancer; Recurrent Bladder Cancer; Recurrent Breast Cancer; Recurrent Carcinoma of Unknown Primary; Recurrent Cervical Cancer; Recurrent Colon Cancer; Recurrent Endometrial Carcinoma; Recurrent Esophageal Cancer; Recurrent Extrahepatic Bile Duct Cancer; Recurrent Gallbladder Cancer; Recurrent Gastric Cancer; Recurrent Gastrointestinal Carcinoid Tumor; Recurrent Islet Cell Carcinoma; Recurrent Malignant Testicular Germ Cell Tumor; Recurrent Mucoepidermoid Carcinoma of the Oral Cavity; Recurrent Non-small Cell Lung Cancer; Recurrent Ovarian Epithelial Cancer; Recurrent Pancreatic Cancer; Recurrent Parathyroid Cancer; Recurrent Prostate Cancer; Recurrent Rectal Cancer; Recurrent Renal Cell Cancer; Recurrent Salivary Gland Cancer; Recurrent Small Intestine Cancer; Recurrent Squamous Cell Carcinoma of the Larynx; Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity; Recurrent Squamous Cell Carcinoma of the Nasopharynx; Recurrent Squamous Cell Carcinoma of the Oropharynx; Recurrent Thyroid Cancer; Recurrent Transitional Cell Cancer of the Renal Pelvis and Ureter; Recurrent Urethral Cancer; Recurrent Vaginal Cancer; Recurrent Vulvar Cancer; Skin Metastases; Small Intestine Adenocarcinoma; Somatostatinoma; Stage III Adenoid Cystic Carcinoma of the Oral Cavity; Stage III Adrenocortical Carcinoma; Stage III Bladder Cancer; Stage III Cervical Cancer; Stage III Colon Cancer; Stage III Endometrial Carcinoma; Stage III Esophageal Cancer; Stage III Follicular Thyroid Cancer; Stage III Gastric Cancer; Stage III Malignant Testicular Germ Cell Tumor; Stage III Mucoepidermoid Carcinoma of the Oral Cavity; Stage III Ovarian Epithelial Cancer; Stage III Pancreatic Cancer; Stage III Papillary Thyroid Cancer; Stage III Prostate Cancer; Stage III Rectal Cancer; Stage III Renal Cell Cancer; Stage III Salivary Gland Cancer; Stage III Squamous Cell Carcinoma of the Larynx; Stage III Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage III Squamous Cell Carcinoma of the Nasopharynx; Stage III Squamous Cell Carcinoma of the Oropharynx; Stage III Vaginal Cancer; Stage III Vulvar Cancer; Stage IIIA Anal Cancer; Stage IIIA Breast Cancer; Stage IIIA Non-small Cell Lung Cancer; Stage IIIB Anal Cancer; Stage IIIB Breast Cancer; Stage IIIB Non-small Cell Lung Cancer; Stage IV Adenoid Cystic Carcinoma of the Oral Cavity; Stage IV Adrenocortical Carcinoma; Stage IV Anal Cancer; Stage IV Bladder Cancer; Stage IV Breast Cancer; Stage IV Colon Cancer; Stage IV Endometrial Carcinoma; Stage IV Esophageal Cancer; Stage IV Follicular Thyroid Cancer; Stage IV Gastric Cancer; Stage IV Mucoepidermoid Carcinoma of the Oral Cavity; Stage IV Non-small Cell Lung Cancer; Stage IV Ovarian Epithelial Cancer; Stage IV Pancreatic Cancer; Stage IV Papillary Thyroid Cancer; Stage IV Prostate Cancer; Stage IV Rectal Cancer; Stage IV Renal Cell Cancer; Stage IV Salivary Gland Cancer; Stage IV Squamous Cell Carcinoma of the Larynx; Stage IV Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage IV Squamous Cell Carcinoma of the Nasopharynx; Stage IV Squamous Cell Carcinoma of the Oropharynx; Stage IVA Cervical Cancer; Stage IVA Vaginal Cancer; Stage IVB Cervical Cancer; Stage IVB Vaginal Cancer; Stage IVB Vulvar Cancer; Thyroid Gland Medullary Carcinoma; Unresectable Extrahepatic Bile Duct Cancer; Unresectable Gallbladder Cancer; Urethral Cancer Associated With Invasive Bladder Cancer; WDHA Syndrome

  18. Post-operative megavoltage irradiation of minor salivary gland malignancies - 30 year follow-up

    Purpose/Objective: To describe the clinical presentation, treatment techniques, outcome, and complications of a large single institutional experience with long-term follow-up after surgery and post-operative radiation therapy for the treatment of minor salivary gland malignancies. Materials and Methods: Fifty-five patients with minor salivary gland tumors were treated definitively between 1966 and 1995. Patients were staged using the 1992 AJCC staging system according to the anatomic site of origin. Follow-up averaged 7.2 years. The mean age at treatment was 54 years. There were 35 men and 20 women. Thirty patients had involved surgical margins and 25 had negative surgical margins. All patients were treated with 4-6 MeV linear accelerators. Radiation techniques included 3 field isocentric or opposed lateral pair techniques depending on the site of origin. The mean radiation dose was 60 Gy (range 50-70 Gy). Survival, both actuarial and relapse free, was determined from the treatment completion date using the method of Kaplan and Meier. Standard statistical tests (Gehan, Cox) were used to calculate the significance of covariates. Results: Minor salivary gland histologic diagnoses included 32 cases of adenoid cystic carcinoma, 15 adenocarcinomas, 7 mucoepidermoid carcinomas, and 1 pleomorphic adenoma. Eight patients had Stage I tumors, 13 had Stage II, another 13 had Stage III lesions, while 21 had Stage IV tumors (locally advanced but non-metastatic). Twenty-five tumors involved the nasal cavity-paranasal sinuses, 23 arose from the oral cavity, 5 from the oropharynx, and 2 from the glottis. Patients with adenoid cystic carcinomas had improved local control and overall survival compared with those with adenocarcinomas (p = 0.03, 0.02, respectively). Malignancies arising from the palate had improved local control rates compared with tumors arising from other anatomic sites (p = 0.04). Patients with Stage I and II disease had improved freedom from relapse compared with those with Stage III and IV disease (p = 0.02). Actuarial 5, 10, and 20-year local control was 87%, 84%, and 65%, respectively. Actuarial 5, 10, and 20-year freedom from relapse was 79%, 72%, and 56%, respectively. Actuarial 5, 10, and 20-year overall survival was 75%, 63%, and 22%, respectively. Actuarial 5, 10, and 20-year disease specific survival was 82%, 79%, 65%, respectively. Actuarial 5, 10, and 20-year event free survival was 70%, 55%, and 17%, respectively. The status of the surgical margins and the dose of post-operative irradiation (between 50 and 70 Gy) did not correlate with the local control rate. There were no statistically significant differences by age or sex. Significant complications of treatment included 2 cases of osteoradionecrosis, 2 prolonged xerostomia, 2 dental disease, 1 cataract, 1 lacrimal dysfunction, and 1 severe fibrosis. Second neoplasms were noted in 7 patients, none of which arose within the radiation field. Conclusion: Resection and post-operative megavoltage radiation therapy of minor salivary gland tumors is well tolerated. High local control, freedom from relapse and survival rates are sustained for many years. Adenoid cystic carcinoma and tumors arising from the palate have the most favorable outcomes. Patients with early stage tumors have improved freedom from relapse compared with those with advanced disease. The status of the surgical margins and the dose of radiation therapy does not correlate with clinical outcome. Combined modality therapy is an effective treatment for minor salivary gland malignancies

  19. Salivary gland carcinomas: prognostic factors for local control and distant metastasis, the role of radiotherapy

    Purpose: The Dutch Head and Neck Oncology Cooperative Group, in which head and neck groups of all University hospitals and the two cancer institutes are represented, initiated a retrospective study concerning salivary gland carcinomas. A majority of Dutch patients with head and neck carcinomas are treated in the participating centres, and the follow-up is precise. Prognostic factors for local control and survival were studied, with special interest in the role of treatment and the role of histologic type. Methods and materials: Results were obtained of 568 patients with a mean follow-up time of 5 years. The parotid gland was involved in 59%, the submandibular gland in 14%, oral cavity in 24% and 3% was located elsewhere. Mean age was 59 years (range 8-100 yr), 48% was female. T-stage was T1 in 27%, T2 in 44%, T3 in 19% and T4 in 11%. Positive necknodes were seen in 15%, 3% was initially M1. Histologic type was acinic cell carcinoma in 12%, mucoepidermoid ca. in 16%, adenoid cystic ca. in 26%, adenoca. in 24%, carcinoma in pleomorphic adenoma in 8%, squamous cell ca. in 6% and undifferentiated ca. in 7%. Resection margins were radical in 37%, close in 20% and irradical in 40% (3% unknown). Surgery was the primary treatment in 501 patients, combined with postoperative radiotherapy (50-70 Gy, mean dose 62 Gy) in 389 patients. Radiotherapy was the primary treatment in 40 patients (18 M1, 30% N+), 20 patients were not treated and 7 patients were treated otherwise. For statistical analysis the Cox PH regression analysis was used (SPSS-PC+). Results: Actuarial local control after 8 years was 80% for surgery alone and 92% for the combined modality (in which more advanced cases prevaled). Independent factors for local control in the surgery±radiotherapy group were: I:T-stage (T3 vs T1-2: RR 3.7; T4 vs T1-2: RR 11.7), II: anatomic site (oral cavity vs parotid and submandibular gland: RR 0.2) and III: treatment modality (surgery alone vs surgery+radiotherapy: RR 7.0). Bone invasion was the only independent histopathological factor for local control. In the primary radiotherapy group a clear dose-response relationship was shown between 60 and 70 Gy (resp. 0% and 55% 5 yr local control). Actuarial distant metastatic free survival after 8 yr was 64%. Independent prognostic factors were: I: T-stage (T2 vs T1: RR3.0, T3 vs T1: RR3.9, T4 vs T1: RR 10.4), II: N-stage (N+ vs N0: RR 3.1) and III: histologic type (acinic cell ca. vs adenoid cystic ca.: RR 0.39, mucoepidermoid ca. vs adenoid cystic ca.: RR 0.29). Conclusion: Multivariate analysis showed that, in patients with salivary gland carcinoma, postoperative radiotherapy independently improved local control. However, small tumors of the oral cavity, when radically resected, may be treated with surgery alone. Histologic type was an independent factor for distant metastasis, but not for local control. In patients treated by primary radiotherapy with curative intent, a local control rate of 55% may be reached using a tumor dose of 70 Gy/ 5 times 2 Gy weekly

  20. Erlotinib and Cetuximab With or Without Bevacizumab in Treating Patients With Metastatic or Unresectable Kidney, Colorectal, Head and Neck, Pancreatic, or Non-Small Cell Lung Cancer

    2014-06-10

    Metastatic Squamous Neck Cancer With Occult Primary Squamous Cell Carcinoma; Recurrent Adenoid Cystic Carcinoma of the Oral Cavity; Recurrent Basal Cell Carcinoma of the Lip; Recurrent Colon Cancer; Recurrent Esthesioneuroblastoma of the Paranasal Sinus and Nasal Cavity; Recurrent Inverted Papilloma of the Paranasal Sinus and Nasal Cavity; Recurrent Lymphoepithelioma of the Nasopharynx; Recurrent Lymphoepithelioma of the Oropharynx; Recurrent Metastatic Squamous Neck Cancer With Occult Primary; Recurrent Midline Lethal Granuloma of the Paranasal Sinus and Nasal Cavity; Recurrent Mucoepidermoid Carcinoma of the Oral Cavity; Recurrent Non-small Cell Lung Cancer; Recurrent Pancreatic Cancer; Recurrent Rectal Cancer; Recurrent Salivary Gland Cancer; Recurrent Squamous Cell Carcinoma of the Hypopharynx; Recurrent Squamous Cell Carcinoma of the Larynx; Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity; Recurrent Squamous Cell Carcinoma of the Nasopharynx; Recurrent Squamous Cell Carcinoma of the Oropharynx; Recurrent Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity; Recurrent Verrucous Carcinoma of the Larynx; Recurrent Verrucous Carcinoma of the Oral Cavity; Stage III Adenoid Cystic Carcinoma of the Oral Cavity; Stage III Basal Cell Carcinoma of the Lip; Stage III Colon Cancer; Stage III Esthesioneuroblastoma of the Paranasal Sinus and Nasal Cavity; Stage III Inverted Papilloma of the Paranasal Sinus and Nasal Cavity; Stage III Lymphoepithelioma of the Nasopharynx; Stage III Lymphoepithelioma of the Oropharynx; Stage III Midline Lethal Granuloma of the Paranasal Sinus and Nasal Cavity; Stage III Mucoepidermoid Carcinoma of the Oral Cavity; Stage III Pancreatic Cancer; Stage III Rectal Cancer; Stage III Salivary Gland Cancer; Stage III Squamous Cell Carcinoma of the Hypopharynx; Stage III Squamous Cell Carcinoma of the Larynx; Stage III Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage III Squamous Cell Carcinoma of the Nasopharynx; Stage III Squamous Cell Carcinoma of the Oropharynx; Stage III Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity; Stage III Verrucous Carcinoma of the Larynx; Stage III Verrucous Carcinoma of the Oral Cavity; Stage IIIB Non-small Cell Lung Cancer; Stage IV Adenoid Cystic Carcinoma of the Oral Cavity; Stage IV Basal Cell Carcinoma of the Lip; Stage IV Colon Cancer; Stage IV Esthesioneuroblastoma of the Paranasal Sinus and Nasal Cavity; Stage IV Inverted Papilloma of the Paranasal Sinus and Nasal Cavity; Stage IV Lymphoepithelioma of the Nasopharynx; Stage IV Lymphoepithelioma of the Oropharynx; Stage IV Midline Lethal Granuloma of the Paranasal Sinus and Nasal Cavity; Stage IV Mucoepidermoid Carcinoma of the Oral Cavity; Stage IV Non-small Cell Lung Cancer; Stage IV Pancreatic Cancer; Stage IV Rectal Cancer; Stage IV Renal Cell Cancer; Stage IV Salivary Gland Cancer; Stage IV Squamous Cell Carcinoma of the Hypopharynx; Stage IV Squamous Cell Carcinoma of the Larynx; Stage IV Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage IV Squamous Cell Carcinoma of the Nasopharynx; Stage IV Squamous Cell Carcinoma of the Oropharynx; Stage IV Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity; Stage IV Verrucous Carcinoma of the Larynx; Stage IV Verrucous Carcinoma of the Oral Cavity; Untreated Metastatic Squamous Neck Cancer With Occult Primary

  1. Alvespimycin Hydrochloride in Treating Patients With Metastatic or Unresectable Solid Tumors

    2013-04-09

    Male Breast Cancer; Recurrent Adenoid Cystic Carcinoma of the Oral Cavity; Recurrent Basal Cell Carcinoma of the Lip; Recurrent Breast Cancer; Recurrent Colon Cancer; Recurrent Esthesioneuroblastoma of the Paranasal Sinus and Nasal Cavity; Recurrent Gastric Cancer; Recurrent Inverted Papilloma of the Paranasal Sinus and Nasal Cavity; Recurrent Lymphoepithelioma of the Nasopharynx; Recurrent Lymphoepithelioma of the Oropharynx; Recurrent Melanoma; Recurrent Metastatic Squamous Neck Cancer With Occult Primary; Recurrent Midline Lethal Granuloma of the Paranasal Sinus and Nasal Cavity; Recurrent Mucoepidermoid Carcinoma of the Oral Cavity; Recurrent Ovarian Epithelial Cancer; Recurrent Prostate Cancer; Recurrent Renal Cell Cancer; Recurrent Salivary Gland Cancer; Recurrent Squamous Cell Carcinoma of the Hypopharynx; Recurrent Squamous Cell Carcinoma of the Larynx; Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity; Recurrent Squamous Cell Carcinoma of the Nasopharynx; Recurrent Squamous Cell Carcinoma of the Oropharynx; Recurrent Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity; Recurrent Verrucous Carcinoma of the Larynx; Recurrent Verrucous Carcinoma of the Oral Cavity; Stage III Adenoid Cystic Carcinoma of the Oral Cavity; Stage III Basal Cell Carcinoma of the Lip; Stage III Colon Cancer; Stage III Esthesioneuroblastoma of the Paranasal Sinus and Nasal Cavity; Stage III Gastric Cancer; Stage III Inverted Papilloma of the Paranasal Sinus and Nasal Cavity; Stage III Lymphoepithelioma of the Nasopharynx; Stage III Lymphoepithelioma of the Oropharynx; Stage III Melanoma; Stage III Midline Lethal Granuloma of the Paranasal Sinus and Nasal Cavity; Stage III Mucoepidermoid Carcinoma of the Oral Cavity; Stage III Ovarian Epithelial Cancer; Stage III Renal Cell Cancer; Stage III Salivary Gland Cancer; Stage III Squamous Cell Carcinoma of the Hypopharynx; Stage III Squamous Cell Carcinoma of the Larynx; Stage III Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage III Squamous Cell Carcinoma of the Nasopharynx; Stage III Squamous Cell Carcinoma of the Oropharynx; Stage III Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity; Stage III Verrucous Carcinoma of the Larynx; Stage III Verrucous Carcinoma of the Oral Cavity; Stage IIIB Breast Cancer; Stage IIIC Breast Cancer; Stage IV Adenoid Cystic Carcinoma of the Oral Cavity; Stage IV Basal Cell Carcinoma of the Lip; Stage IV Breast Cancer; Stage IV Colon Cancer; Stage IV Esthesioneuroblastoma of the Paranasal Sinus and Nasal Cavity; Stage IV Gastric Cancer; Stage IV Inverted Papilloma of the Paranasal Sinus and Nasal Cavity; Stage IV Lymphoepithelioma of the Nasopharynx; Stage IV Lymphoepithelioma of the Oropharynx; Stage IV Melanoma; Stage IV Midline Lethal Granuloma of the Paranasal Sinus and Nasal Cavity; Stage IV Mucoepidermoid Carcinoma of the Oral Cavity; Stage IV Ovarian Epithelial Cancer; Stage IV Prostate Cancer; Stage IV Renal Cell Cancer; Stage IV Salivary Gland Cancer; Stage IV Squamous Cell Carcinoma of the Hypopharynx; Stage IV Squamous Cell Carcinoma of the Larynx; Stage IV Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage IV Squamous Cell Carcinoma of the Nasopharynx; Stage IV Squamous Cell Carcinoma of the Oropharynx; Stage IV Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity; Stage IV Verrucous Carcinoma of the Larynx; Stage IV Verrucous Carcinoma of the Oral Cavity; Unspecified Adult Solid Tumor, Protocol Specific; Untreated Metastatic Squamous Neck Cancer With Occult Primary

  2. Otorrinolaringologia peditrica no Sistema Pblico de Sade de Belo Horizonte / Pediatric (Otolaryngology) at the Public Health System of a city in Southeastern Brazil

    Angela Francisca Marques, Guerra; Denise Utsch, Gonalves; Maria da Conceio Juste Werneck, Crtes; Claudia Regina Lindgren, Alves; Tnia Mara Assis, Lima.

    2007-10-01

    Full Text Available OBJETIVO: Analisar a adequao dos encaminhamentos da ateno primria para a secundria em otorrinolaringologia peditrica. MTODOS: Estudo realizado em Belo Horizonte, estado de Minas Gerais, de maro de 2004 a maio de 2005. Foram avaliadas 408 crianas pr-escolares encaminhadas da ateno primr [...] ia para a secundria do setor de otorrinolaringologia com otite, faringoamigdalite, rinossinusite, rinite alrgica e hipertrofia de amgdala/adenide. As variveis analisadas foram: concordncia dos diagnsticos na ateno primria e secundria, tempo de espera pela consulta, acompanhamento e especialista (mdico de famlia ou pediatra) que examinou a criana na ateno primria. A concordncia dos diagnsticos foi avaliada pela anlise estatstica de kappa. RESULTADOS: Os pacientes tinham em mdia cinco anos de idade, dos quais 214 (52,5%) eram meninos, o tempo mdio de espera pela consulta foi de 3,7 meses. Os diagnsticos na ateno primria e secundria foram, respectivamente: otite (44%, 49%), hipertrofia de amgdala/adenide (22%, 33%), faringoamigdalite (18%, 23%), rinossunusite (13%, 21%), rinite alrgica (3%, 33%). Anlise de concordncia kappa foi 0,15 para otite com efuso, 0,35 para otite recorrente, 0,04 para hipertrofia de amgdala/adenide, 0,43 para faringoamigdalite, 0,05 para rinite alrgica; 0,2 para rinossinusite. Os diagnsticos na ateno primria para encaminhamento secundria, definidos pelo mdico de famlia ou pelo pediatra que avaliou a criana foram concordantes. CONCLUSES: A inadequao dos encaminhamentos da ateno primria para a secundria em otorrinolaringologia foi expressa pelo longo tempo de espera pela consulta e pela baixa concordncia de diagnsticos firmados entre os nveis de ateno para os mesmos pacientes avaliados. A ateno primria poderia se tornar mais eficiente se os profissionais fossem mais bem capacitados em otorrinolaringologia. Abstract in english OBJECTIVE: To assess the suitability of referral from primary to secondary care in pediatric Otolaryngology. METHODS: The study was performed in the city of Belo Horizonte, in the state of Minas Gerais, from March 2004 to May 2005. A total of 408 pre-school children referred from primary care to sec [...] ondary care in the department of Otolaryngology presenting with otitis, tonsillitis, sinusitis, allergic rhinitis, and tonsillar/adenoidal hypertrophy was assessed. The studied variables were: agreement between diagnoses in primary and secondary care; waiting time for doctor's appointment; follow-up, and professional (pediatrician or family physician) that examined children in primary care. Agreement of diagnoses was assessed using kappa statistics. RESULTS: Patients were five years old on average, 214 (52.5%) were boys, mean waiting time for appointment was 3.7 months. Diagnoses in primary and secondary care were respectively: otitis (44%, 49%), tonsillar/adenoidal hypertrophy (22%, 33%), tonsillitis (18%, 23%), sinusitis (13%, 21%), allergic rhinitis (3%, 33%). Agreement analysis of kappa was 0.15 for otitis with effusion, 0.35 for recurrent otitis, 0.04 for tonsillar/adenoidal hypertrophy, 0.43 for tonsillitis, 0.05 for allergic rhinitis, and 0.2 for sinusitis. Diagnoses in primary care referred to secondary care were in agreement when given either by pediatrician or family physician. CONCLUSIONS: Unsuitability of referrals from primary to secondary care in otolaryngology was expressed by the long time waiting for appointments and by the low agreement between diagnoses in different level of care for the same patients. Primary health care could be more efficient if professionals were better qualified in Otolaryngology.

  3. High dose-rate brachytherapy as a treatment option in primary tracheal tumors Braquiterapia de alta taxa de dose como opção terapêutica nos tumores primários da traquéia

    Heloisa de Andrade Carvalho

    2005-08-01

    Full Text Available PURPOSE: To present experience with high dose-rate endobronchial brachytherapy in the treatment of primary tracheal tumors. PATIENTS AND METHODS: Four patients with nonresected primary tracheal tumors are presented: 2 cases of squamous cell carcinoma of the trachea, 1 of recurrent adenoid cystic carcinoma, and 1 with recurrent plasmacytoma. All received brachytherapy, alone or as a boost for primary irradiation, in 3 or 4 fractions of 7.5 Gy, calculated at a depth of 1 cm. Follow-up was considered to start from the end of brachytherapy. RESULTS: Local control was achieved in all cases at the time of first bronchoscopic evaluation. Two patients with squamous cell carcinoma died at 6th and 33rd months after brachytherapy, respectively. The first had no evidence of disease, and the latter had local recurrence. The other 2 patients were alive after 64 and 110 months of follow-up, respectively, both with no evidence of disease. Tracheal stenosis developed in these 2 cases, 22 and 69 months after brachytherapy. Tracheal stent placement was needed only for the patient with an adenoid cystic carcinoma. CONCLUSIONS: Endobronchial high dose-rate brachytherapy may be used for tracheal tumors, even as a boost for external beam irradiation, or in recurrences. Local control in 3 out of 4 patients indicates that individual cases may benefit from the treatment. Long-term survival may also be expected, mainly for tumors with adenoid cystic histology.OBJETIVO: Apresentar a experiência do tratamento de 4 pacientes com tumores primários de traquéia, não operados, submetidos à braquiterapia endobrônquica de alta taxa de dose. PACIENTES E MÉTODOS: Dois casos de carcinoma espinocelular, uma recidiva de carcinoma adenóide cístico e uma recidiva de plasmocitoma primário da traquéia. Todos receberam braquiterapia endobrônquica, exclusiva ou como reforço de dose da radioterapia externa. Foram administradas 3 ou 4 frações de 7,5 Gy cada, calculados a 1 cm de profundidade. O seguimento foi considerado a partir do término da braquiterapia. RESULTADOS: Em todos os casos houve resposta completa. Dois pacientes com carcinoma espinocelular evoluíram a óbito em 6 e 33 meses após a braquiterapia, o primeiro, sem evidência de doença e o outro por recidiva local, respectivamente. As outras 2 pacientes encontravam-se vivas após 64 e 110 meses de seguimento, sem evidência de doença. Esses 2 casos apresentaram estenose traqueal em 22 e 69 meses após a braquiterapia, sendo necessária a colocação de prótese traqueal apenas na paciente com carcinoma adenóide cístico. CONCLUSÕES: A braquiterapia endobrônquica de alta taxa de dose pode ser utilizada tanto como reforço de dose da irradiação externa quanto em recidivas. O controle local obtido em 3 de 4 pacientes indica que casos individuais podem se beneficiar desse procedimento. Sobrevida a longo prazo pode ser observada, principalmente nos casos de histologia adenóide cística.

  4. Tumor de glândula ceruminosa com invasão intracraniana: relato de caso Tumor of ceruminous gland with intracranial invasion: case report

    MÍRIAM C. M. DE CASTRO

    2000-06-01

    Full Text Available As glândulas ceruminosas são glândulas apócrinas modificadas encontradas na região profunda da derme que reveste a porção cartilaginosa do meato acústico externo. Os tumores originados dessas glândulas são raros. Existem controvérsias em relação ao termo ceruminoma, que nos parece impróprio. Na verdade, esses tumores são atualmente classificados como adenoma, adenocarcinoma, carcinoma adenóide cístico e adenoma pleomórfico. Relatamos o caso de uma mulher de 39 anos, apresentado-se com cefaléia, hipoacusia e zumbidos à direita, além de vertigem e náuseas. A TC de crânio evidenciou tumoração do ouvido médio, invadindo os limites ósseos e cartilaginosos, com extensão intracraniana. Foi submetida a cirurgia, com exérese parcial do tumor, seguida de radioterapia (6000 cG. A histologia mostrou tratar-se de carcinoma adenóide cístico de glândulas ceruminosas. A paciente apresentou no pós-operatório paralisia facial periférica à direita, mantendo os déficits anteriores. Após um ano da cirurgia encontra-se estável clinicamente.Ceruminous glands are modified apocrine glands, confined to the skin lining of the cartilaginous part of the external auditory meatus. Tumors arising from these glands are rare. Controversy exists regarding the term "ceruminoma". Actually this neoplasia should be classified as adenoma, adenocarcinoma, adenoid cystic carcinoma and pleomorphic ceruminous adenoma. We report a 39-year-old woman first seen at Santa Casa of Belo Horizonte, in 1998, presenting with headache, nausea, vertigo, hearing loss and tinitus on the right for the past two years. CT scan showed a tumor eroding cartilaginous and bony limits with intracranial invasion. She was submitted to multidisciplinary treatment with surgery followed by radiotherapy (6000 cG. Histology showed a ceruminous adenoid cystic carcinoma. The patient manifested a right peripherical facial palsy and had no recovery of the previous deficits. After one year from surgery she is clinically stable.

  5. Long-term Outcomes and Quality of Life of 186 Patients With Primary Parotid Carcinoma Treated With Surgery and Radiotherapy at the Daniel den Hoed Cancer Center

    Purpose: To assess the outcomes, toxicity, and quality of life (QOL) of patients with primary parotid carcinoma treated with surgery and postoperative radiotherapy at the Daniel den Hoed Cancer Center. Methods and Materials: Between 1995 and 2010, 186 patients with parotid carcinoma were treated with parotidectomy with or without neck dissection, followed by radiotherapy. Elective nodal irradiation (ENI) was applied to high-risk, node-negative disease. End points were locoregional control (LRC), disease-free survival (DFS), cause-specific survival (CSS), and overall survival (OS), late toxicity, and QOL. Results: After a median follow-up of 58 months (range, 4–172 months), the 5-year Kaplan-Meier estimates for LRC, DFS, CSS, and OS were 89%, 83%, 80%, and 68%, respectively. Forty-five events were reported: 24 distant metastases (DM) and 21 locoregional failures (LRF). Event-free survival rates by histological types were 89%, 78%, 76%, 74%, and 70% for acinic cell, mucoepidermoid, adenoid cystic, adenocarcinoma, and squamous cell carcinoma, respectively. More LRF were reported in patients with squamous cell and high-grade mucoepidermoid carcinoma (21% and 19%, respectively) than in patients with other histological types (p = 0.04) and more DM in patients with adenoid cystic and adenocarcinoma (20% and 19%, respectively) than in patients with other types (p = 0.03). None of the high-risk node-negative patients who received ENI developed regional failure. On multivariate analysis, T stage, N stage, grade, and presence of perineural invasion and facial paralysis correlated significantly with DFS. The 5-year cumulative incidence of grade ≥2 late toxicity was 8%. QOL scores deteriorate during and shortly after treatment but returned in almost all scales to baseline scores within 6 months. Conclusions: Of the entire group, surgery and postoperative radiotherapy resulted in excellent outcomes with minimal side effects and preservation of good QOL scores. However, in view of the pattern of failures observed in this study, the role of adjuvant systemic or targeted therapy in patients at high risk of DM should be investigated in prospective trials.

  6. Long-term Outcomes and Quality of Life of 186 Patients With Primary Parotid Carcinoma Treated With Surgery and Radiotherapy at the Daniel den Hoed Cancer Center

    Al-Mamgani, Abrahim, E-mail: a.al-mamgani@erasmusmc.nl [Department of Radiation Oncology, Erasmus Medical Center-Daniel den Hoed Cancer Center, Rotterdam (Netherlands); Rooij, Peter van [Department of Biostatistics, Erasmus Medical Center-Daniel den Hoed Cancer Center, Rotterdam (Netherlands); Verduijn, Gerda M. [Department of Radiation Oncology, Erasmus Medical Center-Daniel den Hoed Cancer Center, Rotterdam (Netherlands); Meeuwis, Cees A. [Department of Otorhinolaryngology, Erasmus Medical Center-Daniel den Hoed Cancer Center, Rotterdam (Netherlands); Levendag, Peter C. [Department of Radiation Oncology, Erasmus Medical Center-Daniel den Hoed Cancer Center, Rotterdam (Netherlands)

    2012-09-01

    Purpose: To assess the outcomes, toxicity, and quality of life (QOL) of patients with primary parotid carcinoma treated with surgery and postoperative radiotherapy at the Daniel den Hoed Cancer Center. Methods and Materials: Between 1995 and 2010, 186 patients with parotid carcinoma were treated with parotidectomy with or without neck dissection, followed by radiotherapy. Elective nodal irradiation (ENI) was applied to high-risk, node-negative disease. End points were locoregional control (LRC), disease-free survival (DFS), cause-specific survival (CSS), and overall survival (OS), late toxicity, and QOL. Results: After a median follow-up of 58 months (range, 4-172 months), the 5-year Kaplan-Meier estimates for LRC, DFS, CSS, and OS were 89%, 83%, 80%, and 68%, respectively. Forty-five events were reported: 24 distant metastases (DM) and 21 locoregional failures (LRF). Event-free survival rates by histological types were 89%, 78%, 76%, 74%, and 70% for acinic cell, mucoepidermoid, adenoid cystic, adenocarcinoma, and squamous cell carcinoma, respectively. More LRF were reported in patients with squamous cell and high-grade mucoepidermoid carcinoma (21% and 19%, respectively) than in patients with other histological types (p = 0.04) and more DM in patients with adenoid cystic and adenocarcinoma (20% and 19%, respectively) than in patients with other types (p = 0.03). None of the high-risk node-negative patients who received ENI developed regional failure. On multivariate analysis, T stage, N stage, grade, and presence of perineural invasion and facial paralysis correlated significantly with DFS. The 5-year cumulative incidence of grade {>=}2 late toxicity was 8%. QOL scores deteriorate during and shortly after treatment but returned in almost all scales to baseline scores within 6 months. Conclusions: Of the entire group, surgery and postoperative radiotherapy resulted in excellent outcomes with minimal side effects and preservation of good QOL scores. However, in view of the pattern of failures observed in this study, the role of adjuvant systemic or targeted therapy in patients at high risk of DM should be investigated in prospective trials.

  7. Cetuximab and Everolimus in Treating Patients With Metastatic or Recurrent Colon Cancer or Head and Neck Cancer

    2012-07-06

    Recurrent Adenoid Cystic Carcinoma of the Oral Cavity; Recurrent Basal Cell Carcinoma of the Lip; Recurrent Colon Cancer; Recurrent Esthesioneuroblastoma of the Paranasal Sinus and Nasal Cavity; Recurrent Inverted Papilloma of the Paranasal Sinus and Nasal Cavity; Recurrent Lymphoepithelioma of the Nasopharynx; Recurrent Lymphoepithelioma of the Oropharynx; Recurrent Metastatic Squamous Neck Cancer With Occult Primary; Recurrent Midline Lethal Granuloma of the Paranasal Sinus and Nasal Cavity; Recurrent Mucoepidermoid Carcinoma of the Oral Cavity; Recurrent Salivary Gland Cancer; Recurrent Squamous Cell Carcinoma of the Hypopharynx; Recurrent Squamous Cell Carcinoma of the Larynx; Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity; Recurrent Squamous Cell Carcinoma of the Nasopharynx; Recurrent Squamous Cell Carcinoma of the Oropharynx; Recurrent Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity; Recurrent Verrucous Carcinoma of the Larynx; Recurrent Verrucous Carcinoma of the Oral Cavity; Stage IV Adenoid Cystic Carcinoma of the Oral Cavity; Stage IV Basal Cell Carcinoma of the Lip; Stage IV Lymphoepithelioma of the Nasopharynx; Stage IV Lymphoepithelioma of the Oropharynx; Stage IV Mucoepidermoid Carcinoma of the Oral Cavity; Stage IV Squamous Cell Carcinoma of the Hypopharynx; Stage IV Squamous Cell Carcinoma of the Larynx; Stage IV Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage IV Squamous Cell Carcinoma of the Nasopharynx; Stage IV Squamous Cell Carcinoma of the Oropharynx; Stage IV Verrucous Carcinoma of the Larynx; Stage IV Verrucous Carcinoma of the Oral Cavity; Stage IVA Colon Cancer; Stage IVA Esthesioneuroblastoma of the Paranasal Sinus and Nasal Cavity; Stage IVA Inverted Papilloma of the Paranasal Sinus and Nasal Cavity; Stage IVA Midline Lethal Granuloma of the Paranasal Sinus and Nasal Cavity; Stage IVA Salivary Gland Cancer; Stage IVA Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity; Stage IVB Colon Cancer; Stage IVB Esthesioneuroblastoma of the Paranasal Sinus and Nasal Cavity; Stage IVB Inverted Papilloma of the Paranasal Sinus and Nasal Cavity; Stage IVB Midline Lethal Granuloma of the Paranasal Sinus and Nasal Cavity; Stage IVB Salivary Gland Cancer; Stage IVB Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity; Stage IVC Esthesioneuroblastoma of the Paranasal Sinus and Nasal Cavity; Stage IVC Inverted Papilloma of the Paranasal Sinus and Nasal Cavity; Stage IVC Midline Lethal Granuloma of the Paranasal Sinus and Nasal Cavity; Stage IVC Salivary Gland Cancer; Stage IVC Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity; Tongue Cancer

  8. Erlotinib Hydrochloride and Cetuximab in Treating Patients With Advanced Gastrointestinal Cancer, Head and Neck Cancer, Non-Small Cell Lung Cancer, or Colorectal Cancer

    2015-09-28

    Adenocarcinoma of the Colon; Adenocarcinoma of the Rectum; Advanced Adult Primary Liver Cancer; Carcinoma of the Appendix; Gastrointestinal Stromal Tumor; Metastatic Gastrointestinal Carcinoid Tumor; Metastatic Squamous Neck Cancer With Occult Primary; Recurrent Adenoid Cystic Carcinoma of the Oral Cavity; Recurrent Adult Primary Liver Cancer; Recurrent Anal Cancer; Recurrent Basal Cell Carcinoma of the Lip; Recurrent Colon Cancer; Recurrent Esophageal Cancer; Recurrent Esthesioneuroblastoma of the Paranasal Sinus and Nasal Cavity; Recurrent Extrahepatic Bile Duct Cancer; Recurrent Gallbladder Cancer; Recurrent Gastric Cancer; Recurrent Gastrointestinal Carcinoid Tumor; Recurrent Inverted Papilloma of the Paranasal Sinus and Nasal Cavity; Recurrent Lymphoepithelioma of the Nasopharynx; Recurrent Lymphoepithelioma of the Oropharynx; Recurrent Metastatic Squamous Neck Cancer With Occult Primary; Recurrent Midline Lethal Granuloma of the Paranasal Sinus and Nasal Cavity; Recurrent Mucoepidermoid Carcinoma of the Oral Cavity; Recurrent Non-small Cell Lung Cancer; Recurrent Pancreatic Cancer; Recurrent Rectal Cancer; Recurrent Salivary Gland Cancer; Recurrent Small Intestine Cancer; Recurrent Squamous Cell Carcinoma of the Hypopharynx; Recurrent Squamous Cell Carcinoma of the Larynx; Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity; Recurrent Squamous Cell Carcinoma of the Nasopharynx; Recurrent Squamous Cell Carcinoma of the Oropharynx; Recurrent Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity; Recurrent Verrucous Carcinoma of the Larynx; Recurrent Verrucous Carcinoma of the Oral Cavity; Small Intestine Adenocarcinoma; Small Intestine Leiomyosarcoma; Small Intestine Lymphoma; Stage IV Adenoid Cystic Carcinoma of the Oral Cavity; Stage IV Anal Cancer; Stage IV Basal Cell Carcinoma of the Lip; Stage IV Colon Cancer; Stage IV Esophageal Cancer; Stage IV Esthesioneuroblastoma of the Paranasal Sinus and Nasal Cavity; Stage IV Gastric Cancer; Stage IV Inverted Papilloma of the Paranasal Sinus and Nasal Cavity; Stage IV Lymphoepithelioma of the Nasopharynx; Stage IV Lymphoepithelioma of the Oropharynx; Stage IV Midline Lethal Granuloma of the Paranasal Sinus and Nasal Cavity; Stage IV Mucoepidermoid Carcinoma of the Oral Cavity; Stage IV Non-small Cell Lung Cancer; Stage IV Pancreatic Cancer; Stage IV Rectal Cancer; Stage IV Salivary Gland Cancer; Stage IV Squamous Cell Carcinoma of the Hypopharynx; Stage IV Squamous Cell Carcinoma of the Larynx; Stage IV Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage IV Squamous Cell Carcinoma of the Nasopharynx; Stage IV Squamous Cell Carcinoma of the Oropharynx; Stage IV Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity; Stage IV Verrucous Carcinoma of the Larynx; Stage IV Verrucous Carcinoma of the Oral Cavity; Tongue Cancer; Unresectable Extrahepatic Bile Duct Cancer; Unresectable Gallbladder Cancer

  9. Availability and quality of paraffin blocks identified in pathology archives: A multi-institutional study by the Shared Pathology Informatics Network (SPIN)

    Shared Pathology Informatics Network (SPIN) is a tissue resource initiative that utilizes clinical reports of the vast amount of paraffin-embedded tissues routinely stored by medical centers. SPIN has an informatics component (sending tissue-related queries to multiple institutions via the internet) and a service component (providing histopathologically annotated tissue specimens for medical research). This paper examines if tissue blocks, identified by localized computer searches at participating institutions, can be retrieved in adequate quantity and quality to support medical researchers. Four centers evaluated pathology reports (1990–2005) for common and rare tumors to determine the percentage of cases where suitable tissue blocks with tumor were available. Each site generated a list of 100 common tumor cases (25 cases each of breast adenocarcinoma, colonic adenocarcinoma, lung squamous carcinoma, and prostate adenocarcinoma) and 100 rare tumor cases (25 cases each of adrenal cortical carcinoma, gastro-intestinal stromal tumor [GIST], adenoid cystic carcinoma, and mycosis fungoides) using a combination of Tumor Registry, laboratory information system (LIS) and/or SPIN-related tools. Pathologists identified the slides/blocks with tumor and noted first 3 slides with largest tumor and availability of the corresponding block. Common tumors cases (n = 400), the institutional retrieval rates (all blocks) were 83% (A), 95% (B), 80% (C), and 98% (D). Retrieval rate (tumor blocks) from all centers for common tumors was 73% with mean largest tumor size of 1.49 cm; retrieval (tumor blocks) was highest-lung (84%) and lowest-prostate (54%). Rare tumors cases (n = 400), each institution's retrieval rates (all blocks) were 78% (A), 73% (B), 67% (C), and 84% (D). Retrieval rate (tumor blocks) from all centers for rare tumors was 66% with mean largest tumor size of 1.56 cm; retrieval (tumor blocks) was highest for GIST (72%) and lowest for adenoid cystic carcinoma (58%). Assessment shows availability and quality of archival tissue blocks that are retrievable and associated electronic data that can be of value for researchers. This study serves to compliment the data from which uniform use of the SPIN query tools by all four centers will be measured to assure and highlight the usefulness of archival material for obtaining tumor tissues for research

  10. Availability and quality of paraffin blocks identified in pathology archives: A multi-institutional study by the Shared Pathology Informatics Network (SPIN

    Schirripa Osvaldo

    2007-02-01

    Full Text Available Abstract Background Shared Pathology Informatics Network (SPIN is a tissue resource initiative that utilizes clinical reports of the vast amount of paraffin-embedded tissues routinely stored by medical centers. SPIN has an informatics component (sending tissue-related queries to multiple institutions via the internet and a service component (providing histopathologically annotated tissue specimens for medical research. This paper examines if tissue blocks, identified by localized computer searches at participating institutions, can be retrieved in adequate quantity and quality to support medical researchers. Methods Four centers evaluated pathology reports (19902005 for common and rare tumors to determine the percentage of cases where suitable tissue blocks with tumor were available. Each site generated a list of 100 common tumor cases (25 cases each of breast adenocarcinoma, colonic adenocarcinoma, lung squamous carcinoma, and prostate adenocarcinoma and 100 rare tumor cases (25 cases each of adrenal cortical carcinoma, gastro-intestinal stromal tumor [GIST], adenoid cystic carcinoma, and mycosis fungoides using a combination of Tumor Registry, laboratory information system (LIS and/or SPIN-related tools. Pathologists identified the slides/blocks with tumor and noted first 3 slides with largest tumor and availability of the corresponding block. Results Common tumors cases (n = 400, the institutional retrieval rates (all blocks were 83% (A, 95% (B, 80% (C, and 98% (D. Retrieval rate (tumor blocks from all centers for common tumors was 73% with mean largest tumor size of 1.49 cm; retrieval (tumor blocks was highest-lung (84% and lowest-prostate (54%. Rare tumors cases (n = 400, each institution's retrieval rates (all blocks were 78% (A, 73% (B, 67% (C, and 84% (D. Retrieval rate (tumor blocks from all centers for rare tumors was 66% with mean largest tumor size of 1.56 cm; retrieval (tumor blocks was highest for GIST (72% and lowest for adenoid cystic carcinoma (58%. Conclusion Assessment shows availability and quality of archival tissue blocks that are retrievable and associated electronic data that can be of value for researchers. This study serves to compliment the data from which uniform use of the SPIN query tools by all four centers will be measured to assure and highlight the usefulness of archival material for obtaining tumor tissues for research.

  11. Allergic rhinitis and its associated co-morbidities at Bugando Medical Centre in Northwestern Tanzania; A prospective review of 190 cases

    Said Said A

    2012-11-01

    Full Text Available Abstract Background Allergic rhinitis is one of the commonest atopic diseases which contribute to significant morbidity world wide while its epidemiology in Tanzania remains sparse. There was paucity of information regarding allergic rhinitis in our setting; therefore it was important to conduct this study to describe our experience on allergic rhinitis, associated co-morbidities and treatment outcome in patients attending Bugando Medical Centre. Methods This was descriptive cross-sectional study involving all patients with a clinical diagnosis of allergic rhinitis at Bugando Medical Centre over a three-month period between June 2011 and August 2011. Data was collected using a pre-tested coded questionnaire and analyzed using SPSS statistical computer software version 17.0. Results A total of 190 patients were studied giving the prevalence of allergic rhinitis 14.7%. The median age of the patients was 8.5 years. The male to female ratio was 1:1. Adenoid hypertrophy, tonsillitis, hypertrophy of inferior turbinate, nasal polyps, otitis media and sinusitis were the most common co-morbidities affecting 92.6% of cases and were the major reason for attending hospital services. Sleep disturbance was common in children with adenoids hypertrophy (?2?=?28.691, P?=?0.000. Allergic conjunctivitis was found in 51.9%. The most common identified triggers were dust, strong perfume odors and cold weather (P??2?=?4.583, P?=?0.032. In this study family history of allergic rhinitis was not a significant risk factor (P =0.423. The majority of patients (68.8% were treated surgically for allergic rhinitis co morbidities. Post operative complication and mortality rates were 2.9% and 1.6% respectively. The overall median duration of hospital stay of in-patients was 3 days (2 28 days. Most patients (98.4% had satisfactory results at discharge. Conclusion The study shows that allergic rhinitis is common in our settings representing 14.7% of all otorhinolaryngology and commonly affecting children and adolescent. Sufferers seek medical services due to co-morbidities of which combination of surgical and medical treatment was needed. High index of suspicions in diagnosing allergic rhinitis and early treatment is recommended.

  12. Apport diagnostique de la cervicotomie exploratrice: étude rétrospective de 300 cas

    Darouassi, Youssef; Chihani, Mehdi; Touati, Mohamed Mliha; Ammar, Haddou; Bouaity, Brahim

    2015-01-01

    Les tuméfactions cervicales représentent un motif fréquent de consultation, et les adénopathies en constituent l’étiologie la plus fréquente. L'examen clinique et les bilans paracliniques permettent, dans la majorité des cas de retrouver une étiologie. Néanmoins certaines de ces tuméfactions restent d'origine non précisée, portant donc l'indication d'une cervicotomie exploratrice. Il s'agit d'une étude rétrospective d'une série de 300 cas de tuméfactions cervicales isolées colligées au service d'ORL de l'hôpital militaire Avicenne de Marrakech entre 2001 et 2014. Tous nos patients ont bénéficié d'une cervicotomie exploratrice avec étude anatomo-pathologique. L’âge des patients varie entre 1 et 76 ans avec un âge moyen de 32,57 ans et une légère prédominance masculine de 52%. La symptomatologie qui a motivé une consultation chez 81% des patients était la tuméfaction latérocervicale. La localisation la plus fréquente était sous mandibulaire (33,34%). Les tuméfactions d'installation progressive ont été retrouvées chez 93,34% des patients. Les principales étiologies retrouvées dans notre étude après examen anatomopathologique étaient de deux types: soit d'origine ganglionnaire dominées par la tuberculose ganglionnaire cervicale (53,66%), le lymphome malin non hodgkinien (6,66%), les adénites réactionnelles non spécifiques (4,66%), la maladie deHodgkin (4,33%) et les métastases ganglionnaires cervicales (3,33%); soit d'origine non ganglionnaire dont le lipome cervicale (17,66%), les kystes branchiaux (6%), les kystes du tractus thyréoglosse (1,66%) et le lymphangiome kystique (1,66%). A la lumière des résultats obtenus et des données de la littérature, nous allons discuter l'intérêt et l'utilité de la cervicotomie exploratrice dans le diagnostic étiologique des tuméfactions cervicales lorsque les examens cliniques et paracliniques ne sont pas concluants, et ainsi d'analyser les aspects épidémiologiques, cliniques et paracliniques des différentes étiologies retrouvées. La cervicotomie exploratrice reste, avec l’étude anatomo-pathologique, un outil nécessaire pour le diagnostic de certitude de certaines tuméfactions cervicales malgré son caractère invasif. PMID:27022424

  13. A comparative study on the clinical and polysomnographic pattern of obstructive sleep apnea among obese and non-obese subjects

    Rajiv Garg

    2012-01-01

    Full Text Available Objective: This study was designed to compare the pattern of obstructive sleep apnea (OSA among obese and nonobese subjects regarding clinical and polysomnographic data obtained for a polysomnographic study. Methods: A cross-sectional retrospective descriptive study was conducted by analyzing polysomnographic data in 112 consecutive patients underwent a sleep study at our sleep laboratory from January 2009 to July 2010. Out of them, 81 were diagnosed to have OSA (apnea-hypopnoea Index ≥5. These patients were classified in two groups with body mass index (BMI 0.001. The minimal oxygen saturation was lower in the obese than the nonobese group (68.5 ± 13.00 vs. 80.3 ± 7.40, P0.001 and was well below 90% in both groups. Overall, the OSA in nonobese patients was mild-to-moderate as compared to that of the obese and no significant differences were observed between them as regard to age, gender, mean neck circumference, excessive daytime sleepiness, adenoid or tonsillar enlargement, smoking, and remaining polysomnographic parameters. Conclusion: Obstructive sleep apnea can occur in nonobese persons though with less severity as compared to obese leading to a concept that OSA is not restricted to obese persons only and there is a high demand of its awareness regarding evaluation, diagnosis, and management in such individuals.

  14. (18)F-FDG Uptake Characteristics in Differentiating Benign from Malignant Nasopharyngeal Lesions in Children.

    Ma, Chao; Zou, Renjian; Huo, Yanlei; Chen, Suyun; Wang, Shaoyan; Wu, Shuqi; Ye, Zhiyi; Wu, Zhenyu; Fang, Feng; Wang, Hui

    2015-01-01

    The characteristics of FDG uptake in the physiologic and malignant nasopharynx were investigated in the paper which was correlated with either pathologic findings or clinical follow-up. Three patients had pathologically established nasopharyngeal malignancy. In the 3 nasopharyngeal malignancies, 2 had diffusely and expansively increased FDG uptake, and one had asymmetric uptake. Our results indicated that the difference between adenoid hypertrophy and malignancy is asymmetric or diffusely expansive (18)F-FDG uptake with or without correlating morphologic lesion on diagnostic CT in children under 10 years of age. The typical characteristics of physiologic and inflammatory (18)F-FDG uptake in nasopharynx are symmetrically trapezoid. Diffusely increased nasopharyngeal FDG uptake can be considered physiologic if SUVmax is less than 7.6 but should be carefully assessed by pharyngorhinoscopy if SUVmax is greater than 11 and there is no correlating morphologic lesion on diagnostic CT. The diffusely, expansively increased uptake, and asymmetric uptake in particular, should be considered as malignancy. Further biopsy is especially indicated in patients with retropharyngeal space and bilateral cervical lymph node abnormality but no history of malignancy. PMID:26576420

  15. Clinical study on osteoradionecrosis of the jaws

    In the present study osteoradionecrosis which had developed after radiotherapy for malignant tumor was studied clinically and therapeutically and the following results were obtained. 1. The subjects were 28 patients with squamous cell carcinoma and 2 patients with adenoid cystic carcinoma aged 38 to 72. The ratio of male: female was 3.3 : 1. The time of manifestation was 1 month-14 years after irradiation. The main symptoms were pain and exposed bone mainly in the region of mandibular molar tooth. 2. Osteoradionecrosis was observed in 10 cases supposed to be induced by tooth extraction but also in 5 edentulous cases. 3. When the osteoradionecrosis cases were classified into limited area type and wide range type on the basis of clinical findings. X-ray of the jaws showed the presence of bone resorption and induration together in many wide range type cases. 4. Scintigram of bone showed widespread accumulation of radiation even in clinically limited area type, and the picture of some loss of bone and the intensity of the accumulation were considered to be extremely useful as an index in making therapeutical plans and decisions on the prognosis of tumor of the jaws. 5. As the method of treatment, sequestrectomy was performed in 14 of 19 cases of the limited area type and 4 of 11 cases of the wide range type and excision of the jaws in 4 cases. 6. Hyperbaric oxygen therapy was carried out in 3 cases and had good effect. (J.P.N.)

  16. Cisplatin-induced Casepase-3 activation in different tumor cells

    Shi, Hua; Li, Xiao; Su, Ting; Zhang, Yu-Hai

    2008-12-01

    Apoptosis plays an essential role in normal organism development which is one of the main types of programmed cell death to help tissues maintain homeostasis. Defective apoptosis can result in cell accumulation and therefore effects on tumor pathogenesis, progression and therapy resistance. A family of proteins, known as caspases, is typically activated in the early stages of apoptosis. Therefore, studying the kinetics of activation of caspases induced by antitumor drugs can contribute to antitumor drug discovery and explanation of the molecular mechanisms. This paper detected the Caspase-3 activity induced by cisplatin in human adenoid cystic carcinoma cell line (ACC-M), human hepatocellular liver carcinoma cell line (HepG2) and human epithelial carcinoma cell line (Hela) with stably expressing ECFP-DEVDDsRed (CD3) probe, a fluorescent probe consisting of Enhanced Cyan Fluorescent Protein (ECFP), red fluorescent protein (DsRed) and a linker with a recognition site of Caspase-3, by using the capillary electrophoresis (CE) and fluorescence resonance energy transfer (FRET) imaging system. Under the same concentration of cisplatin, ACC-M cells responded the most rapidly, and then HepG2 cells and Hela cells, respectively, in the early 30 hours. Later, HepG2 cells represented acceleration in the Caspase-3 activation speed and reached full activation the earliest comparing to other two cell types. The results demonstrated that ACC-M cell is more sensitive than the other two cell types under the treatment of cisplatin.

  17. Metastatic Salivary Gland Tumors: A Single-Center Study Demonstrating the Feasibility and Potential Clinical Benefit of Molecular-Profiling-Guided Therapy.

    Popovtzer, Aron; Sarfaty, Michal; Limon, Dror; Marshack, Gideon; Perlow, Eli; Dvir, Addie; Soussan-Gutman, Lior; Stemmer, Salomon M

    2015-01-01

    We evaluated the use of molecular profiling (MP) for metastatic salivary gland adenoid cystic carcinoma (SACC), for which there is no standard treatment. MP (Caris Molecular Intelligence) was performed on biopsy samples from all metastatic SACC patients attending a tertiary medical center between 2010 and 2013 (n = 14). Treatment was selected according to the biomarkers identified. Findings were compared with all similarly diagnosed patients treated in the same center between 1996 and 2009 (n = 9). For each patient, MP identified 1-13 biomarkers associated with clinical benefit for specific therapies (most commonly low/negative TS, low ERCC1). Eleven patients (79%) received MP-guided treatment (2 died prior to treatment initiation, 1 opted not to be treated), with complete response in 1, partial response (PR) in 3, and stable disease in 4. In the historical controls, 2 patients (22%) were treated (1 had PR). Median (range) progression-free survival in the first line after MP was 8.2 months (1.4-49.5+). Median (range) overall survival from diagnosis of metastatic disease was 31.3 (1.4-71.1+) versus 14.0 (1.5-116) months in the historical controls. In conclusion, MP expands treatment options and may improve clinical outcomes for metastatic SACC. In orphan diseases where randomized trials cannot be performed, MP could become a standard clinical tool. PMID:26448941

  18. Masses of the tongue and floor of the mouth: findings on magnetic resonance imaging

    The purpose of this study was to determine the value of MR imaging for the demonstration of masses in the tongue and floor of the mouth. Nine patients were prospectively examined with MR imaging after physical examination. Imaging protocol included T2 and contrast-enhanced and non-contrast-enhanced T1-weighted turbo spin-echo sequences, and the findings were compared with surgical and histopathological results. Histopathological examination revealed four squamous cell carcinomas, one adenoid cystic carcinoma, two tongue abscesses, and one chronic inflammatory change. The other case was diagnosed as hemangioma depending on clinical and imaging findings alone. In cases with squamous cell carcinoma, staging was done on the basis of MR imaging findings, and was found to be T4 in two cases, T3 in one case, and T2 in another. The primary role of MR imaging of the tongue and oropharynx is not to make a tissue diagnosis. Multiple deep biopsies are mandatory for the differentiation of other inflammatory and neoplastic lesions. Magnetic resonance imaging produces coronal and sagittal image planes to assess the volume and spread of the lesion and helps the surgeon determine the direction in which the biopsy should be performed. (orig.)

  19. Utility of a Herpes Oncolytic Virus for the Detection of Neural Invasion By Cancer

    Ziv Gil

    2008-04-01

    Full Text Available Prostate, pancreatic, and head and neck carcinomas have a high propensity to invade nerves. Surgical resection is a treatment modality for these patients, but it may incur significant deficits. The development of an imaging method able to detect neural invasion (NI by cancer cells may guide surgical resection and facilitate preservation of normal nerves. We describe an imaging method for the detection of NI using a herpes simplex virus, NV1066, carrying tyrosine kinase and enhanced green fluorescent protein (eGFP. Infection of pancreatic (MiaPaCa2, prostate (PC3 and DU145, and adenoid cystic carcinoma (ACC3 cell lines with NV1066 induced a high expression of eGFP in vitro. An in vivo murine model of NI was established by implanting tumors into the sciatic nerves of nude mice. Nerves were then injected with NV1066, and infection was confirmed by polymerase chain reaction. Positron emission tomography with [18F]-2′-fluoro-2′-deoxyarabinofuranosyl-5-ethyluracil performed showed significantly higher uptake in NI than in control animals. Intraoperative fluorescent stereoscopic imaging revealed eGFP signal in NI treated with NV1066. These findings show that NV1066 may be an imaging method to enhance the detection of nerves infiltrated by cancer cells. This method may improve the diagnosis and treatment of patients with neurotrophic cancers by reducing injury to normal nerves and facilitating identification of infiltrated nerves requiring resection.

  20. "Comparison of recovery rate and sequelae of various location of ventilation tube insertion "

    Abbas Safavi Naini S

    2002-08-01

    Full Text Available Ventilation tube (VT insertion is the most common otologic operations performed in children, which has great importance in recovery and prevention of hearing loss in children with Eustachian tube dysfunction in critical ages of growth development. The location of the VT insertion varies in different studies; the differences are in recovery rates and sequelae of VT insertion. This study is performed to compare results of various locations of VT insertion in hearing recovery rate and postoperative sequelae in the Booali Hospital from 1999 to 2000 (one-year period. This investigation is a clinical trial in 34 patients with Eustachian tube dysfunction; cases were selected according to history, otologic examination, adenoid radiography, audiometry (SRT, PTA-GAP and tympanometry. The operating time consumed in the VT insertion and postoperative sequelae were recorded. Recovery rates of SAR and PTA-Gap were 25.14 dB and 18.41 dB in anterosuperior (AS versus 18/67 dB and 14/85 dB in anteroinferior (AT VT insertion respectively. Obstruction and otorrhea after VT insertion were 0, 4 and 13, 11 in AS and AI, respectively. Time difference in the AS versus AI was not significant. The assessment confirmed that anterosuperior VT insertion has better hearing recovery rate and lower postoperative sequelae.