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Sample records for carcinome adenoide kystique

  1. Adenoid cystic carcinoma of the breast; Carcinome adenoide kystique du sein

    Energy Technology Data Exchange (ETDEWEB)

    Kallel, R.; Bahri Zouari, I.; Gouiaa, N.; Charfi, S.; Ayadi, L.; Makni, S.; Sellami Boudawara, T. [CHU Habib-Bourguiba, Lab. d' Anatomie et de Cytologie Pathologiques, Sfax (Tunisia); Daoud, E. [CHU Habib Bourguiba, Service de Radiologie, Sfax (Tunisia); Daoud, J. [CHU Habib Bourguiba, Service de Radiotherapie, Sfax (Tunisia)

    2009-07-15

    Adenoid cystic carcinoma of the breast is a rare neoplasm, accounting for only 0.1% of all malignant breast tumours. It is more common in women in the sixth decade of their lives and often in the sub areolar area. The clinical criteria is not specific and the radiographic examination showed a benign-appearing tumour. The preoperative diagnosis is possible with fine-needle aspiration cytology. The diagnosis is made by histological examination, presented a difficult differential diagnosis with cribriform carcinoma; so it is necessary to use histochemical or immunohistochemical techniques. The treatment is not well established. It consists of lumpectomy with radiation or mastectomy. Compared to other locations, adenoid cystic carcinoma of the breast has a favorable prognosis. Lymph node involvement or distant metastases seldom occur. The aim of our study is to describe the epidemiological, clinico pathological characteristics, the treatment and the prognosis of this rare type of breast tumour. (authors)

  2. Adenoid cystic carcinoma of the head and neck; Les carcinomes adenoides kystiques de la tete et du cou

    Energy Technology Data Exchange (ETDEWEB)

    Haddad, H.; Riahi, H.; Chekrine, T.; Benchakroun, N.; Jouhadi, H.; Tawfiq, N.; Sahraoui, S.; Benider, A. [Centre d' oncologie Ibn-Rochd, Casablanca, (Morocco)

    2007-11-15

    The adenoid cystic carcinoma or cylindroma develop principally from salivary glands. It is the most frequently at the level of head and neck. The aim of this work is to analyse the therapy data and to determine the prognostic factors of adenoid cystic carcinomas through a retrospective study. (N.C.)

  3. Carcinome papillaire intra-kystique du sein: à propos de trois cas

    OpenAIRE

    El Mazghi, Abderrahman; Bouhafa, Touria; Loukili, Kaoutar; El Kacemi, Hanan; Lalya, Issam; Kebdani, Taieb; Hassouni, Khalid

    2014-01-01

    Le Carcinome papillaire intra-kystique du sein est une entité très rare et représente 0,5 à 1% de l'ensemble des carcinomes mammaires. Il se caractérise généralement par une croissance lente avec un bon pronostic. Nous rapportons 03 nouveaux cas prouvés histologiquement, chez des patientes traitées par chirurgie radicale ou conservatrice, suivie d'une radiothérapie sur le sein en place et une hormonothérapie à base de tamoxifen chez les deux patientes avec des récepteurs hormonau...

  4. Literature review on the role of radiotherapy in the treatment of nasopharyngeal cystic adenoid carcinomas about two cases; Revue de la litterature sur la place de la radiotherapie dans le traitement des carcinomes adenoides kystiques du nasopharynx a propos de deux cas

    Energy Technology Data Exchange (ETDEWEB)

    Hemmich, M.; Hassouni, K.; Elkacemi, H.; Errachdi, A.; Mouhajir, N.; Zaidi, H.; Benjaafar, N. [Institut national d' oncologie, Rabat (Morocco)

    2011-10-15

    The authors discuss the characteristics and the radiotherapy treatment procedures of cystic adenoid carcinomas, and more precisely the treatment of two of such cases of nasopharyngeal carcinomas. The first one had an incomplete resection surgery followed by curing radiotherapy: he has then been in local-regional control situation for 8 months. The second one had lung metastases, was treated chemotherapy and radiotherapy (decompressive treatment), and died six months after diagnosis. Radiotherapy is considered to be the treatment basis, whereas chemotherapy is a matter of controversy. Short communication

  5. Tonsils and Adenoids

    Science.gov (United States)

    Your tonsils and adenoids are part of your lymphatic system. Your tonsils are in the back of your throat. Your adenoids ... in through your mouth and nose. Sometimes your tonsils and adenoids become infected. Tonsillitis makes your tonsils sore and ...

  6. Pneumatose kystique iléale révélée par un volvulus du grêle

    OpenAIRE

    Khalid Aït Taleb; Karim Ibn Majdoub; Khalid Mazaz; Abdelmalek Ousadden; El Bachir Benjelloun; Hicham El bouhaddouti

    2010-01-01

    La pneumatose kystique intestinale est une pathologie rare qui se caractérise par la présence de kystes gazeux dans la paroi intestinale. Elle est asymptomatique ou pauci symptomatique, et le plus souvent découverte lors d’un examen d’imagerie ou d’endoscopie. Nous rapportons un cas de pneumatose iléale compliquée d’un volvulus sur bride chez un patient jamais opéré auparavant.

  7. Pneumatose kystique iléale révélée par un volvulus du grêle

    Directory of Open Access Journals (Sweden)

    Khalid Aït Taleb

    2010-08-01

    Full Text Available La pneumatose kystique intestinale est une pathologie rare qui se caractérise par la présence de kystes gazeux dans la paroi intestinale. Elle est asymptomatique ou pauci symptomatique, et le plus souvent découverte lors d’un examen d’imagerie ou d’endoscopie. Nous rapportons un cas de pneumatose iléale compliquée d’un volvulus sur bride chez un patient jamais opéré auparavant.

  8. Enlarged Adenoids (For Parents)

    Science.gov (United States)

    ... as if the nostrils are pinched noisy breathing snoring stopped breathing for a few seconds during sleep ( ... About Adenoids Having Your Tonsils Taken Out Tonsillitis Snoring What Happens in the Operating Room? The Scoop ...

  9. Carcinome épidermoïde verruqueux palpébrale: à propos d'un cas

    Science.gov (United States)

    Tzili, Nazih; El Yamouni, Oubaida; El Khaoua, Mahfoud; Mellal, Zakaria; Sefiani, Sanae; Berraho, Amina

    2014-01-01

    Le carcinome épidermoïde verruqueux est une forme rare du carcinome épidermoïde et se caractérise par une malignité essentiellement locale. La localisation palpébrale est exceptionnelle. Nous rapportons le cas d'une patiente de 70 ans, suivi en consultation pour tumeur palpébrale volumineuse simulant un kératoacanthome de l’œil droit. La biopsie révèle un carcinome épidermoïde verruqueux. Une exérèse chirurgicale de la totalité de la tumeur avec reconstruction de la paupière ont été réalisées. On n'a pas noté de récidive pendant les 6 mois suivant le traitement chirurgical. Il s'agit du quatrième cas de carcinome épidermoide verruqueux à localisation palpébrale reporté dans la littérature. PMID:25400860

  10. Sphenoid sinus adenoid cystic carcinoma

    OpenAIRE

    Marambaia, Otavio; Gomes, Amaury Machado; Marambaia, Pablo Pinillos; Pimentel, Kleber; Almeida, Fabio Siqueira Costa

    2008-01-01

    Introduction: The sphenoid adenoid cystic carcinoma is a rare malign neoplasm, in the head and neck and when located in the paranasal sinuses, it is formed in the minor salivary glands. It grows slowly and is characterized by a large invasion of the adjacent tissues, and also has a large capacity of metastasis. The surgery associated with post-operative radiotherapy is used as treatment. Objective: To describe a case of sphenoid sinus adenoid cystic carcinoma in a male, black, 62 year patient...

  11. Tonsils and Adenoids PostOp

    Science.gov (United States)

    ... the nose and the roof of the mouth. Tonsils and adenoids are often removed when they become enlarged and ... surgery. Scabs : A scab will form where the tonsils and adenoids were removed. These scabs are thick, white, and ...

  12. Sphenoid sinus adenoid cystic carcinoma

    Directory of Open Access Journals (Sweden)

    Marambaia, Otavio

    2008-12-01

    Full Text Available Introduction: The sphenoid adenoid cystic carcinoma is a rare malign neoplasm, in the head and neck and when located in the paranasal sinuses, it is formed in the minor salivary glands. It grows slowly and is characterized by a large invasion of the adjacent tissues, and also has a large capacity of metastasis. The surgery associated with post-operative radiotherapy is used as treatment. Objective: To describe a case of sphenoid sinus adenoid cystic carcinoma in a male, black, 62 year patient. Case Report: N.L.B., 62 years of age, male, had bloody rhinorrhea for 6 months associated with bilateral nasal obstruction. The nasofibroscopy showed lesion of polypoid aspect in the left nasal cavity. He was submitted to biopsy and the anatomopathological exam showed adenoid cystic carcinoma and the patient was forwarded to oncology. Conclusions: The importance of conducting the differential diagnosis between chronic nasosinusal infection and nasosinusal tumors.

  13. Assessment of Adenoid Size in Children

    Directory of Open Access Journals (Sweden)

    2008-01-01

    Full Text Available Adenoid hypertrophy is one of the most common diseases in the pediatric population, and can cause nasal obstruction, snoring, mouth breathing, and alteration in facial development in children. Flexible fiberoptic nasolaryngoscopey was the gold standard method for evaluation of adenoid and nasopharyngeal obstruction. The aim of this study was evaluation results and agreement of flexible flexible fiberoptic nasolaryngoscopey, Adenoid lateral x-ray and intraoperative observation diagnosis of adenoid hypertrophy and its intensity. In a cross-sectional and descriptive-analytical study, 50 pediatric patients who had suffered from nasal obstruction and mouth breathing were selected in this study to undergo adenoidectomy. The size of adenoid measured by flexible fiberoptic nasolaryngoscopey, lateral neck radiography and intraoperative observation of adenoid size. Results of three studied methods in diagnosis of adenoid hypertrophy and its severity were compared. Twenty two of patients were boy and 28 of them were girl. Mean age of patients was 6.26 ? 1.81 year in the range of 3-12 year. The agreement rate of Lateral Neck Radiography in determination of adenoid hypertrophy with intraoperative observation of adenoid size and flexible fiberoptic nasolaryngoscopey was 70 and 50%, respectively and between flexible fiberoptic nasolaryngoscopey and intraoperative observation of adenoid size was 72% and between three methods was 48%. The agreement rate of each three methods in diagnosis of adenoid hypertrophy was 100%. Significantly strong correlation was found between intraoperative observation of adenoid size with lateral neck radiography and flexible fiberoptic nasolaryngoscopey and poor correlation was found between Lateral Neck Radiography and flexible fiberoptic nasolaryngoscopey.

  14. Adenoidal size in lateral roentgenogram of skull

    International Nuclear Information System (INIS)

    Adenoid is a kind of tonsil located in the posterior wall of the nasopharynx. Enlargement of the adenoid can produce obstruction of the nasopharynx and eustachian tube. Disturbance in discharge of nasal and paranasal secretions can be a cause of chronic rhinitis, sinusitis and otitis media. The diagnosis of enlarged adenoid by inspection is difficult due to its location. In the lateral roentgenogram of the skull the anterior wall of the adenoid is sharply delineated by air in the nasopharynx. The authors measured the sizes of adenoid and nasopharynx and calculated the adenoid-nasopharyngeal ratio (AN ratio) from 1,000 simple skull lateral roentgenograms of the children between the age of 0 to 16 years. Adenoid size is gradually increasing in the children up to 9 years of age but almost uncharged in the older age group. The AN ratio is highest in the age group of 8-9 years. In the age groups above 9 years of age the AN ratio is gradually decreased due to atrophic changes of the adenoid

  15. Métastase cérébrale d'un carcinome du col utérin

    Science.gov (United States)

    Chekrine, Tarik; Hassouni, Abdesalam; Jouhadi, Hassan; Sahraoui, Souha; Bouchbika, Zineb; Taleb, Amina; Benchakroun, Nadia; Tawfiq, Nezha; Benider, Abdellatif

    2013-01-01

    Les métastases cérébrales des cancers du col de l?utérus sont extrêmement rares. Elles sont généralement supra-tentorielles, survenant à un stade avancé de la maladie et dans un cadre de néoplasie polymétastatique. La tumeur primitive est le plus souvent un carcinome épidermoïde peu différencié. Leur pronostic reste sombre malgré toutes les options thérapeutiques. Vu la rareté de cet événement et le peu de cas publiés dans la littérature, nous rapportons l'observation clinique d'une jeune patiente de 44 ans, opérée pour un carcinome du col utérin et qui présente 14 mois plus tard des métastases cérébrales sus et sous tentorielles associées à des métastases ganglionnaires lombo-aortique, médiastinale et sus-claviculaire. Elle a bénéficié d'un traitement palliatif associant une chimiothérapie et une radiothérapie pan encéphalique. Devant l'altération rapide de l'état général, la patiente a été mise sous un traitement symptomatique et des soins de support. PMID:23717727

  16. Adenoid cystic carcinoma of the breast.

    OpenAIRE

    Hopkins, G. Bruce; Tullis, Richard H.

    1983-01-01

    Adenoid cystic carcinomas of breast are rarely recorded tumors affording an excellent prognosis. This present report documents three new cases and reviews the literature. Histologic features distinguishing it from cribriform intraductal carcinoma are emphasized.

  17. Métastase cérébrale d'un carcinome du col utérin

    OpenAIRE

    Chekrine, Tarik; Hassouni, Abdesalam; Jouhadi, Hassan; Sahraoui, Souha; Bouchbika, Zineb; Taleb, Amina; Benchakroun, Nadia; Tawfiq, Nezha; Benider, Abdellatif

    2013-01-01

    Les métastases cérébrales des cancers du col de l?utérus sont extrêmement rares. Elles sont généralement supra-tentorielles, survenant à un stade avancé de la maladie et dans un cadre de néoplasie polymétastatique. La tumeur primitive est le plus souvent un carcinome épidermoïde peu différencié. Leur pronostic reste sombre malgré toutes les options thérapeutiques. Vu la rareté de cet événement et le peu de cas publiés dans la littérature, nous rapportons l'observation ...

  18. Adenoid Reservoir for Pathogenic Biofilm Bacteria?

    OpenAIRE

    Nistico, L.; Kreft, R.; Gieseke, A.; Coticchia, J. M.; Burrows, A.; Khampang, P.; Liu, Y.; Kerschner, J. E.; Post, J. C.; Lonergan, S.; Sampath, R.; Hu, F. Z.; Ehrlich, G. D.; Stoodley, P.; Hall-stoodley, L.

    2011-01-01

    Biofilms of pathogenic bacteria are present on the middle ear mucosa of children with chronic otitis media (COM) and may contribute to the persistence of pathogens and the recalcitrance of COM to antibiotic treatment. Controlled studies indicate that adenoidectomy is effective in the treatment of COM, suggesting that the adenoids may act as a reservoir for COM pathogens. To investigate the bacterial community in the adenoid, samples were obtained from 35 children undergoing adenoidectomy for ...

  19. Subglottic adenoid cystic carcinoma mistaken for asthma

    OpenAIRE

    Wang, Hua-lin; Xu, Lin; Li, Fu-jun

    2009-01-01

    Adenoid cystic carcinoma rarely occurs within the subglottic larynx. In this study, a case of subglottic adenoid cystic carcinoma was reported. A 54 year-old Chinese woman developed a sudden onset of chest distress and cough worsening after physical exertion, and was diagnosed with, and treated as, bronchial asthma. Regular anti-asthmatic therapy did not improve the symptoms. Until a sudden dyspnea, a cervicothoracic computerized tomography (CT) revealed that her upper airway was obstructed b...

  20. Carcinome épidermoïde du sein: à propos de 3cas et revue de la littérature

    Science.gov (United States)

    Alaoui, Fatima Zohra Fdili; Benkirane, Saad; Chaara, Hekmat; Bouguern, Hakima; Melhouf, Moulay Abdilah

    2012-01-01

    Les carcinomes épidermoides du sein sont rares. Ils sont d'origine métaplasiques. Leur histogénèse est controversée. La présentation clinique et mammographique n'est pas spécifique, l'aspect kystisé des lésions et la présence de nécrose sont recherchés à l’échographie mammaire. Le diagnostic est histologique. Ce cancer est réputé être peu lymphophile et non hormonodépendant. Le traitement rejoint celui des carcinomes infiltrants canalaires et repose sur la chirurgie, la radiothérapie et la chimiothérapie. Le pronostic est péjoratif. Nous rapportons trois cas de carcinome épidermoide du sein colligés au service de Gynécologie obstétrique II au CHU Hassan II de Fès et une revue de la littérature. PMID:22891096

  1. Carcinome colloïde du sein: à propos d'un cas

    OpenAIRE

    Laabadi, Kamilia; Jayi, Sofia; Alaoui, Fatimazohra Fdili; Bouguern, Hakima; Chaara, Hikmat; Melhouf, My Abdelilah

    2013-01-01

    Nous rapportons le cas d'une tumeur colloïde du sein chez un homme. Cette situation rare interpelle par son mode de découverte. Nous avons pris en charge un homme de 60 ans atteint d'une lésion rétro-aréolaire droite classée cliniquement T4b N1 M0 et suspecte radiologiquement. L'analyse histologique (microbiopsie) a conclu à un carcinome colloïde muqueux associé à une petite composante canalaire classique de grade I de SBR du sein. Les traitements complémentaires associent mastecto...

  2. Carcinome épidermoïde du sein: à propos de 3cas et revue de la littérature

    OpenAIRE

    Alaoui, Fatima Zohra Fdili; Benkirane, Saad; Chaara, Hekmat; Bouguern, Hakima; Melhouf, Moulay Abdilah

    2012-01-01

    Les carcinomes épidermoides du sein sont rares. Ils sont d'origine métaplasiques. Leur histogénèse est controversée. La présentation clinique et mammographique n'est pas spécifique, l'aspect kystisé des lésions et la présence de nécrose sont recherchés à l’échographie mammaire. Le diagnostic est histologique. Ce cancer est réputé être peu lymphophile et non hormonodépendant. Le traitement rejoint celui des carcinomes infiltrants canalaires et repose sur la chirurgie, la ra...

  3. Pneumatose kystique intestinale révélée par une sténose d'une anastomose gastro-jéjunale: à propos d'un cas

    Science.gov (United States)

    El Matiallah, Mohammed Amine; El Bouhaddouti, Hicham; Mouaqit, Ouadii; Benjelloun, El Bachir; Ousadden, Abdelmalek; Taleb, Khalid Ait

    2013-01-01

    La pneumatose kystique intestinale est la présence de bulles gazeuses dans la paroi et les séreuses du tube digestif. Il s'agit d'une pathologie bénigne, rare, de diagnostic radiologique et de traitement médical. Nous rapportons le cas d'un homme âgé de 42ans, opéré il y a 6ans pour une sténose du bulbe duodénal d'origine ulcéreuse, il avait bénéficié d'une gastro-entéro-anastomose avec bivagotomie tronculaire. Il a été hospitalisé pour des vomissements associés à des épigastralgies. le patient a bénéficié d'une fibroscopie oeso-gastro-duodénale qui a trouvé une stase gastrique gênant toute exploration, ce qui a conduit à la réalisation d'une tomodensitométrie abdominale qui a objectivé un énorme estomac de stase en amont d'une sténose de l'anastomose gastro jéjunale, une pneumatose kystique intestinale et un pneumopéritoine. Le patient a été opéré et l'exploration a trouvé une ascite, un volumineux estomac de stase et des adhérences entre le grêle et le colon droit, sièges de la pneumatose, provoquant un tour de spire (volvulus) de l'ancienne anastomose gastro-jéjunale. L'estomac était atone. Une gastrectomie des 2/3 emportant l'ancienne anastomose suivie d'une anastomose type Finsterer manuelle a été réalisée. Les suites post opératoires étaient simples. La pneumatose kystique intestinale est une affection bénigne, de diagnostic radiologique. Le scanner permet d’étudier la diffusion des gaz dans les séreuses digestives. Son traitement est habituellement médical alors que ses complications peuvent relever d'un traitement chirurgical comme pour notre patient. PMID:24255731

  4. Carcinome colloïde du sein: à propos d'un cas

    Science.gov (United States)

    Laabadi, Kamilia; Jayi, Sofia; Alaoui, Fatimazohra Fdili; Bouguern, Hakima; Chaara, Hikmat; Melhouf, My Abdelilah

    2013-01-01

    Nous rapportons le cas d'une tumeur colloïde du sein chez un homme. Cette situation rare interpelle par son mode de découverte. Nous avons pris en charge un homme de 60 ans atteint d'une lésion rétro-aréolaire droite classée cliniquement T4b N1 M0 et suspecte radiologiquement. L'analyse histologique (microbiopsie) a conclu à un carcinome colloïde muqueux associé à une petite composante canalaire classique de grade I de SBR du sein. Les traitements complémentaires associent mastectomie, curage, chimiothérapie, radiothérapie et hormonothérapie. Le cancer du sein est rare chez l'homme. Le carcinome colloïde est exceptionnel puisqu'il représente seulement 1 à 6% de l'ensemble des cancers du sein. Il est encore plus rare chez l'homme. Ces tumeurs touchent une population spécifique et ont un meilleur pronostic que les autres types prépondérant dans les cancers du sein chez l'homme. A travers cette observation et une revue de la littérature, nous essaierons de discuter les principales caractéristiques anatomo-cliniques et évolutives de cette forme rare du cancer du sein. PMID:24772222

  5. Pneumatose kystique intestinale révélée par une sténose d'une anastomose gastro-jéjunale: à propos d'un cas

    OpenAIRE

    El Matiallah, Mohammed Amine; El Bouhaddouti, Hicham; Mouaqit, Ouadii; Benjelloun, El Bachir; Ousadden, Abdelmalek; Taleb, Khalid Ait

    2013-01-01

    La pneumatose kystique intestinale est la présence de bulles gazeuses dans la paroi et les séreuses du tube digestif. Il s'agit d'une pathologie bénigne, rare, de diagnostic radiologique et de traitement médical. Nous rapportons le cas d'un homme âgé de 42ans, opéré il y a 6ans pour une sténose du bulbe duodénal d'origine ulcéreuse, il avait bénéficié d'une gastro-entéro-anastomose avec bivagotomie tronculaire. Il a été hospitalisé pour des vomissements associés à des épi...

  6. Adenoid cystic carcinoma of the breast

    International Nuclear Information System (INIS)

    Adenoid cystic carcinoma of the breast is a rare neoplasm, accounting for only 0.1% of all malignant breast tumours. It is more common in women in the sixth decade of their lives and often in the sub areolar area. The clinical criteria is not specific and the radiographic examination showed a benign-appearing tumour. The preoperative diagnosis is possible with fine-needle aspiration cytology. The diagnosis is made by histological examination, presented a difficult differential diagnosis with cribriform carcinoma; so it is necessary to use histochemical or immunohistochemical techniques. The treatment is not well established. It consists of lumpectomy with radiation or mastectomy. Compared to other locations, adenoid cystic carcinoma of the breast has a favorable prognosis. Lymph node involvement or distant metastases seldom occur. The aim of our study is to describe the epidemiological, clinico pathological characteristics, the treatment and the prognosis of this rare type of breast tumour. (authors)

  7. Paediatric refractory rhinosinusitis secondary to hypertrophied adenoids: management and review of literature.

    Directory of Open Access Journals (Sweden)

    Gautham MK

    2014-06-01

    Full Text Available Background /Objectives: Hypertrophied adenoids are the most common cause of refractory sinusitis in paediatric age. We study 42 cases of patients of chronic adenoiditis with adenoid facies and refractory chronic rhinosinusitis managed by endoscopic assisted adenoidectomy (EAA and conventional adenoidectomy (CA. Materials and method: 42 cases of chronic refractory sinusitis with adenoid facies secondary to hypertrophied adenoids were randomized into 2 groups during the study period of 12 months from August 2012 to July 2013. Group A (n=21 underwent endoscope assisted adenoidectomy and Group B(n=21 underwent conventional adenoidectomy. Result: Endoscopic assisted adenoidectomy proves to be more effective in managing adenoid facies and chronic refractory rhinosinusitis with adenoid hyperplasia. Conclusion: Visualization of the adenoid mass using endoscope helps complete removal of the diseased adenoids. Endoscopic assisted adenoidectomy is treatment of choice in adenoid facies and chronic refractory rhinosinusitis with adenoid hyperplasia and more effective than conventional adenoidectomy.

  8. Assessment of nasopharyngeal airway and adenoid by MRI

    International Nuclear Information System (INIS)

    Adenoid is a kind of tonsil located in the posterior wall of nasopharynx. Enlargement of the adenoid can produce obstruction of the nasopharynx and Eustachian tube. Disturbance in discharge of nasal and paranasal secretions can be a cause of chronic rhinitis, sinusitis, and otitis media. Diagnosis of enlarged adenoid simply by inspection is different due to its location. Measurement of nasopharyngeal airway and adenoid using lateral radiographs of nasopharynx may be inaccurate for magnification and rotation. It was some limitations in demonstrating the actual state of nasopharyngeal airway and adenoid because it gives only two dimensional information. The authors measured the size and areas of nasopharyngeal airway and adenoid using MRI with sagittal and oblique coronal pilot views of T1 weighted spin echo. We categorized the patients into 4 groups according to the scoring system by symptoms such as apnea, mouth breathing, and snoring. The results of several measurment and their ratios were evaluated in these 4 categorized patients. The ratios of area of adenoid and nasopharyngeal airway (AA/Na) in each patient group were 6.52, 7.76, 10.53, 15.93, respectively. And the ratios of adenoid and nasopharyngeal airway (A/N) by Fujioka's method were 0.6, 0.65, 0.69, 0.71, respectively. We found that AA/Na might be the most effective index as an objective indicator in the evaluation of nasopharyngeal obstruction by the enlarged adenoidd

  9. Adenoid cystic carcinoma of the head and neck

    International Nuclear Information System (INIS)

    The adenoid cystic carcinoma or cylindroma develop principally from salivary glands. It is the most frequently at the level of head and neck. The aim of this work is to analyse the therapy data and to determine the prognostic factors of adenoid cystic carcinomas through a retrospective study. (N.C.)

  10. Paediatric refractory rhinosinusitis secondary to hypertrophied adenoids: management and review of literature.

    OpenAIRE

    Mk, Gautham; Ravishankara S; Naik, Sudhir M.; Sathya P2; Mohan Appaji; Shankarnarayan Bhat; Ravi Karumbiah

    2014-01-01

    Background /Objectives: Hypertrophied adenoids are the most common cause of refractory sinusitis in paediatric age. We study 42 cases of patients of chronic adenoiditis with adenoid facies and refractory chronic rhinosinusitis managed by endoscopic assisted adenoidectomy (EAA) and conventional adenoidectomy (CA). Materials and method: 42 cases of chronic refractory sinusitis with adenoid facies secondary to hypertrophied adenoids were randomized into 2 groups during the study p...

  11. Is Helicobacter pylori really present in the adenoids of children?

    Science.gov (United States)

    Bitar, Mohamed A; Soweid, Assaad; Mahfouz, Rami; Zaatari, Ghazi; Fuleihan, Nabil

    2005-12-01

    Adenoid hyperplasia is a common cause of nasal obstruction in the pediatric age group. Recently, the adenoids were shown to harbor Helicobacter pylori (HP) based only on the rapid urease test (RUT). We conducted this pilot study to identify the presence of HP in the adenoids histologically and assess the reliability of both the RUT and histology in detecting HP in an extragastric location, using nested (two-steps) polymerase chain reaction (nPCR). Consecutive patients undergoing adenoidectomy for obstructive adenoid hyperplasia were enrolled. Adenoid specimens were subjected to the RUT. Histological sections stained with hematoxylin and eosin, Giemsa and Warthin-Starry were examined. We then used nPCR to detect the presence of HP in the studied specimens. Twenty-five patients (3-10 years; mean of 5.5 years) were enrolled. Twenty-one (84%) adenoids were positive by the RUT. Seventeen (68%) had bacteria on histological sections; four (16%) contained HP-like organisms. However, all specimens were negative by nPCR. No patient had a history of symptoms suggestive of laryngopharyngeal reflux within 6 months of the study. In conclusion, the children enrolled in this study did not have HP in their adenoids. High false positive results can occur with the RUT when used on adenoid tissues. It is not possible to rely solely on morphology to detect HP in an extragastric location. The nPCR remains the best way to identify HP accurately, but does not imply its presence in an active role. PMID:15924276

  12. Primary Adenoid Cystic Carcinoma Presenting as an Orbital Apex Tumor

    OpenAIRE

    Venkitaraman, Ramachandran; Madhavan, Jayaprakash; Ramachandran, Krishnankuttynair; Abraham, Elizabeth; Rajan, Balakrishnan

    2008-01-01

    Primary adenoid cystic carcinoma occurring in the orbital apex is rare. We present the clinical features of a patient who initially presented with the clinical and radiologic features of an orbital pseudotumor. He developed features of orbital apex syndrome and repeat imaging showed a tumor of the orbital apex with intracranial invasion. He underwent radical skull base surgery and pathologic examination revealed adenoid cystic carcinoma in the orbital apex with a normal lacrimal apparatus. He...

  13. [Vegetative adaptation in children presenting with chronic adenoiditis].

    Science.gov (United States)

    Tervo, S O; Voronchikhina, N V; Kalashnikova, T P

    2010-01-01

    Publications reporting the comprehensive analysis of the psychovegetative status in children with chronic adenoiditis are practically lacking in the literature. The objective of the present work was to study the functional state of the vegetative nervous system (vegetative nerve tone, vegetative reactivity, and vegetative regulation of vital activity) and manifestations of vegetative disorders in the clinical picture of chronic adenoiditis in preschool children. PMID:21311452

  14. Adenoid cystic carcinoma of the peripheral lung: a case report

    OpenAIRE

    Kitada Masahiro; Ozawa Keisuke; Sato Kazuhiro; Hayashi Satoshi; Tokusashi Yoshihiko; Miyokawa Naoyuki; Sasajima Tadahiro

    2010-01-01

    Abstract Adenoid cystic carcinoma of the peripheral lung is a rare entity. We recently encountered a patient with adenoid cystic carcinoma. A 75-year-old woman showed a nodular lesion with 10 mm in diameter in the right upper lung field on chest radiography. The diagnosis was unclear, but lung cancer could not be ruled out. Thoracoscopic biopsy was performed, and intraoperative pathological diagnosis revealed the carcinoma of the lung. We enforced upper lobectomy and mediastinal lymph node di...

  15. Le carcinome verruqueux de la vulve: à propos de quatre cas

    Science.gov (United States)

    Boujoual, Majdouline; Hachi, Hafid; Rimani, Mouna; El Khannoussi, Basma; Bougtab, Abdesslam

    2014-01-01

    Le cancer verruqueux de la vulve est une variante rare et bien différenciéedu carcinome épidermoïdedont les particularités diagnostiques, thérapeutiques et pronostiques méritent d’être distinguées. Il se caractérise par son importante croissance exophytique sans infiltration de la membrane basale. Son évolution est surtout locale rarement métastatique. Il est l'indication d'un traitement chirurgical exclusif avec exérèse large sans curage ganglionnaire de principe. La radiothérapie n'apporte aucun bénéfice en survie. Le pronostic est relativement bon mais grevé par les récidives locales. Nous rapportons quatre cas de carcinome verruqueux de la vulve colligés au Service de Chirurgieà l'Institut National d'Oncologie Rabat, nous discuterons à travers une revue de littérature, leurs modalités diagnostiques thérapeutiques et évolutives. PMID:25328599

  16. Le carcinome verruqueux de la vulve: à propos de quatre cas

    OpenAIRE

    Boujoual, Majdouline; Hachi, Hafid; Rimani, Mouna; El Khannoussi, Basma; Bougtab, Abdesslam

    2014-01-01

    Le cancer verruqueux de la vulve est une variante rare et bien différenciéedu carcinome épidermoïdedont les particularités diagnostiques, thérapeutiques et pronostiques méritent d’être distinguées. Il se caractérise par son importante croissance exophytique sans infiltration de la membrane basale. Son évolution est surtout locale rarement métastatique. Il est l'indication d'un traitement chirurgical exclusif avec exérèse large sans curage ganglionnaire de principe. La radioth?...

  17. Adenoid cystic carcinoma of breast: Recent advances.

    Science.gov (United States)

    Miyai, Kosuke; Schwartz, Mary R; Divatia, Mukul K; Anton, Rose C; Park, Yong Wook; Ayala, Alberto G; Ro, Jae Y

    2014-12-16

    Adenoid cystic carcinoma (ACC) of the breast is a rare special subtype of breast cancer characterized by the presence of a dual cell population of luminal and basaloid cells arranged in specific growth patterns. Most breast cancers with triple-negative, basal-like breast features (i.e., tumors that are devoid of estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 expression, and express basal cell markers) are generally high-grade tumors with an aggressive clinical course. Conversely, while ACCs also display a triple-negative, basal-like phenotype, they are usually low-grade and exhibit an indolent clinical behavior. Many discoveries regarding the molecular and genetic features of the ACC, including a specific chromosomal translocation t(6;9) that results in a MYB-NFIB fusion gene, have been made in recent years. This comprehensive review provides our experience with the ACC of the breast, as well as an overview of clinical, histopathological, and molecular genetic features. PMID:25516849

  18. Clinicopathological review and survival characteristics of adenoid cystic carcinoma.

    Science.gov (United States)

    Binesh, Fariba; Akhavan, Ali; Masumi, Omid; Mirvakili, Abbas; Behniafard, Nasim

    2015-03-01

    To study the clinical characters, the outcomes of treatments and the factors affecting treatment results of adenoid cystic carcinomas at Shahid Sadoughi Hospital and Shahid Ramazanzadeh radiotherapy center, Yazd, Iran. The clinical data of 31 patients with adenoid cystic carcinoma of any anatomic site diagnosed over an 8 year period (2004-2012), were investigated retrospectively. Data regarding patients' characteristics, pathological features and follow-up were obtained from patients records. Survival rate, local recurrence and distant metastasis were analyzed using Kaplan-Meier method. Prognosis factors were analyzed by Log-rank test and Cox regression. The study included31 patients with adenoid cystic carcinoma. The mean age at presentation was 50.2 ± 24.8 years. There were 11 (35.5 %) males and 20 (64.5 %) females with a female predilection (M:F = 0.55:1). Parotid gland was the most common site (8/31, 25.7 %) followed by submandibular gland (7/31, 22.6 %). Perineural invasion was detected in 67.7 % of the cases. Positive surgical status was reported in 48.4 % of the specimens. Metastasis was detected in 25.8 % of the patients and the most common site of distant metastasis was lung. Overall survival rates at 2, 5, and 7 years were 95, 75, and 57 % respectively. Margin status showed significant effect on survival (P value = 0.01). Positive surgical margin is an important factor affecting the prognosis of the patients with adenoid cystic carcinoma. Surgery with negative surgical margin is the first choice of treatment for the patients with adenoid cystic carcinoma. Our findings show that the prognosis of patients with adenoid cystic carcinoma in our center is fair. PMID:25621256

  19. Rehabilitation of an advanced case of adenoid cystic carcinoma.

    Science.gov (United States)

    Volpato, Luiz Evaristo Ricci; Caldas, Lorena Frange; Castro, Paulo Henrique de Souza; de Carvalhosa, Artur Aburad; Volpato, Maria Carmen Palma Faria; Bandéca, Matheus Coelho; Borges, Álvaro Henrique

    2015-01-01

    Adenoid cystic carcinoma is a cancer of the salivary gland that primarily affects the parotid, submandibular, and accessory salivary glands. Its growth is slow and it has infiltrative nature. A 46-year-old female patient coming from the rural area presented a lesion on the palate and reported pain in the region for three years. After incisional biopsy, and histopathological diagnosis of adenoid cystic carcinoma of the cribriform type of minor salivary gland, superior hemimaxillectomy and adjuvant treatment with radiotherapy and maxillofacial prosthetic rehabilitation were performed. PMID:25709844

  20. Metastatic adenoid cystic carcinoma of lung: a case report.

    Science.gov (United States)

    Mohindroo, Shobha; Sharma, Jai Shree

    2006-10-01

    A 48 year old male patient, operated five years back for sub mandibular swelling proved on histopathologic examination to be adenoid cystic carcinoma presented in the ENT department, I. G. medical hospital with pain on both sides of the chest. CT scan of the chest showed multiple lesions of variable sizes. CT guided FNAC as well as biopsy of the lung lesion was performed. Cytodiagnosis and histopathological examinations revealed features of cribiform type of adenoid cystic carcinoma. This case is reported here for its metastasis to the lungs and prolonged survival even with multiple metastasis. PMID:17183870

  1. Rehabilitation of an Advanced Case of Adenoid Cystic Carcinoma

    Science.gov (United States)

    Volpato, Luiz Evaristo Ricci; Caldas, Lorena Frange; Castro, Paulo Henrique de Souza; de Carvalhosa, Artur Aburad; Volpato, Maria Carmen Palma Faria; Bandéca, Matheus Coelho; Borges, Álvaro Henrique

    2015-01-01

    Adenoid cystic carcinoma is a cancer of the salivary gland that primarily affects the parotid, submandibular, and accessory salivary glands. Its growth is slow and it has infiltrative nature. A 46-year-old female patient coming from the rural area presented a lesion on the palate and reported pain in the region for three years. After incisional biopsy, and histopathological diagnosis of adenoid cystic carcinoma of the cribriform type of minor salivary gland, superior hemimaxillectomy and adjuvant treatment with radiotherapy and maxillofacial prosthetic rehabilitation were performed. PMID:25709844

  2. Radiographic adenoid evaluation - suggestion of referral parameters / Avaliação radiográfica da adenoide - sugestão de parâmetros de referência

    Scientific Electronic Library Online (English)

    Murilo F.N., Feres; Juliana S., Hermann; Ana C., Sallum; Shirley S.N., Pignatari.

    2014-06-01

    Full Text Available SciELO Brazil | Languages: English, Portuguese Abstract in portuguese OBJETIVO: o objetivo deste estudo foi de investigar a utilidade de medidas radiográficas destinadas à avaliação da tonsila faríngea a serem utilizadas como potenciais parâmetros de encaminhamento. MÉTODOS: crianças de quatro a 14 anos, de ambos os gêneros, que apresentavam queixas referentes à [...] obstrução nasal foram submetidas à radiografia do cavum. Os registros radiográficos (n = 120) foram avaliados de acordo com parâmetros categóricos e quantitativos, e dados resultantes foram comparados ao exame padrão-ouro de videonasofaringoscopia, em relação às suas taxas de acurácia (sensibilidade, valor preditivo negativo, especificidade e valor preditivo positivo). RESULTADOS: os parâmetros radiográficos categóricos apresentaram baixa sensibilidade para a identificação de pacientes portadores de 2/3 de obstrução do espaço coanal. No entanto, alguns destes parâmetros apresentaram especificidades relativamente altas quando 3/4 de obstrução coanal era o ponto de corte de interesse. Dentre as variáveis quantitativas, um modelo matemático se mostrou mais adequado para identificar pacientes com mais de 2/3 de obstrução coanal. CONCLUSÃO: este modelo demonstrou, assim, ser potencialmente útil como método de rastreamento para identificação de pacientes com pelo menos 2/3 de obstrução adenoidiana. Além disso, um dos parâmetros categóricos analisados demonstrou ser relativamente mais útil e potencialmente seguro para eliminar pacientes queixosos com menos de 3/4 de obstrução a serem indicados à adenoidectomia. Abstract in english OBJECTIVE: this study aimed to evaluate the usefulness of current radiographic measurements, which were originally conceived to evaluate adenoid hypertrophy, as potential referral parameters. METHODS: children aged from 4 to 14 years, of both genders, who presented nasal obstruction complaints [...] , were subjected to cavum radiography. Radiographic examinations (n = 120) were evaluated according to categorical and quantitative parameters, and data were compared to gold-standard videonasopharyngoscopic examination, regarding accuracy (sensitivity, negative predictive value, specificity, and positive predictive value). RESULTS: radiographic grading systems presented low sensitivity for the identification of patients with two-thirds choanal space obstruction. However, some of these parameters presented relatively high specificity rates when three-quarters adenoid obstruction was the threshold of interest. Amongst the quantitative variables, a mathematical model was found to be more suitable for identifying patients with more than two-thirds obstruction. CONCLUSION: this model was shown to be potentially useful as a screening tool to include patients with, at least, two-thirds adenoid obstruction. Moreover, one of the categorical parameters was demonstrated to be relatively more useful, as well as a potentially safer assessment tool to exclude patients with less than three-quarters obstruction, to be indicated for adenoidectomy.

  3. Diagnosis and Treatment of Tracheal or Bronchuotracheal Adenoid Cystic Carcinoma

    Directory of Open Access Journals (Sweden)

    Ming QIN

    2010-06-01

    Full Text Available Background and objective Adenoid cystic carcinoma is primary bronchopulmonary carcinoma with low malignancy, and 43 patients treated in the past 50 years in our hospital were retrospectively studied. The aim of this study is to discuss the clinical symptoms, pathologic characteristic and therapeutic method of primary tracheal or bronchuotracheal adenoid cystic carcinoma. Methods This study summarized total 43 patients of primary tracheal or bronchus adenoid cystic carcinoma treated in our hospital from Jan. 1958 to Dec. 2007. Among them, 40 patients were treated by surgical resection, and 3 patients were treated by fiberoptic bronchoscope’s interventional treatment. Results The 1-yr, 3-yr, 5-yr survival rates of the 43 patients above were 100% (41/41, 89.5% (34/38, 87.1% (27/31, respectively. Conclusion Primary tracheal or bronchus adenoid cystic carcinoma are rare and low malignancy carcinoma. The clinical symptoms of them are not typical. The best treatment is early detection and taking measures of operation plus radiotherapy. The other palliative treatment is fiberoptic bronchoscope’s interventional treatment.

  4. Carcinoma adenoide quístico primario de bronquio lobar: Caso clínico / Primary adenoid cystic carcinoma of the lobar bronehus: Case report

    Scientific Electronic Library Online (English)

    LEONIDAS, TAPIAS-VARGAS; LUIS FELIPE, TAPIAS-VARGAS; LEONIDAS, TAPIAS; MARÍA EMMA, GARCÍA; JULIO CÉSAR, MANTILLA; ERNESTO, GARCÍA.

    2011-02-01

    Full Text Available SciELO Chile | Language: Spanish Abstract in spanish El carcinoma adenoide quístico primario de la vía aérea es una neoplasia muy rara. Reportamos el caso de un paciente de 60 años de edad quien consultó por hemoptisis y disnea de esfuerzo. Una tomografía computarizada del tórax reveló una masa en el bronquio fuente y lobar superior del pulmón derecho [...] . Se realizó una lobectomía superior derecha en manguito. El estudio histopatológico mostró un carcinoma adenoide quístico. Se administró radioterapia adyuvante. La cirugía y la radioterapia son las bases del manejo de este tipo de tumores. Abstract in english Primary airway adenoid cystic carcinoma is very uncommon. We report a 60 years old male consulting for hemoptysis and dyspnea. A chest CAT scan showed a mass in the right superior lobar bronehus. The patient was subjected to a right superior sleeve lobectomy and the pathological study of the surgica [...] l piece revealed an adenoid cystic carcinoma. The patient received adjuvant radiotherapy. Surgery and radiation therapy are the mainstay of treatment for this type of tumors.

  5. Carcinome épidermoïde de la vulve sur une grossesse gémellaire: à propos d’un cas aux cliniques universitaires de Lubumbashi

    OpenAIRE

    Idi, Yves Isango; Muteya, Michel Manika; Ngama, Christian Kakisingi; Mwazaz, Roger Munan; Makinko, Paul Ilunga; Kaj, Fanny Malonga; Tambwe, Albert Mwembo; Mukalenge, Faustin Chenge

    2013-01-01

    Nous rapportons un cas de carcinome épidermoïde de la vulve chez gestante porteuse d’une grosse gémellaire qui a consulté dans le service de gynéco-obstetrique des Cliniques Universitaires de Lubumbashi à un stade avancé de la pathologie et après avoir essayé un traitement insuffisant ailleurs.

  6. Carcinome mucineux primitif cutané: à propos de deux cas et d'une revue de la literature

    Science.gov (United States)

    Souaf, Ihsane; Ameurtesse, Hassania; Debbagh, Fatema Zehra; Idrissi, Karima; Znati, Kawter; Amarti, Affaf

    2014-01-01

    Le carcinome mucineux primitif cutané est une tumeur annexielle rare, développée à partir des glandes sudoripares. Il se localise en générale à l'extrémité céphalique, surtout la région périorbitaire. Nous rapportons deux observations d'un carcinome mucineux primitif de la face et de la région axillaire, chez deux patients âgés de 60 ans. L’étude histologique montrait une prolifération tumorale dermohypodermique, faite de cellules organisées en cordons, en amas et en massif cribriformes, au sein d'une substance mucoïde. En immunohistochimie les cellules tumorales exprimaient la cytokératine 7, l'EMA et les récepteurs hormonaux. L'actine musculaire lisse a bien marqué les cellules myoépithéliales au niveau de la composante in situ dans un seul cas. Le carcinome mucineux primitif cutané est difficile à différencier d'une métastase mammaire ou digestive. La mise en évidence de carcinome in situ ou de cellules myoépithéliale est en faveur de l'origine cutanée primitive. C'est une tumeur à croissance lente, avec des métastases exceptionnelles. Le traitement est chirurgical et le taux de récidive est très élevé. Et à travers ces deux observations, les auteurs mettent en relief les principaux aspects cliniques, histologiques, thérapeutiques de cette entité avec une revue de la littérature. PMID:25574316

  7. Reprodutibilidade dos métodos radiográficos para avaliação da adenoide / Reliability of radiographic parameters in adenoid evaluation

    Scientific Electronic Library Online (English)

    Murilo Fernando Neuppmann, Feres; Helder Inocêncio Paulo de, Sousa; Sheila Márcia, Francisco; Shirley Shizue Nagata, Pignatari.

    2012-08-01

    Full Text Available Embora a avaliação radiográfica da hipertrofia de tonsila faríngea tenha sido constantemente debatida, há ainda carência de estudos que testem a confiabilidade da maioria dos parâmetros radiográficos existentes. OBJETIVO: Verificar a reprodutibilidade intra e interexaminadores de vários métodos dest [...] inados à avaliação da tonsila faríngea. Forma de estudo: Estudo de série, metodológico e transversal. MATERIAL E MÉTODO: Quarenta crianças de ambos os sexos, de 4 a 14 anos, foram selecionadas mediante apresentação de queixas de obstrução nasal ou respiração oral, com suspeita de diagnóstico de hipertrofia de tonsila faríngea. Radiografias do cavum faríngeo e telerradiografias ortodônticas foram obtidas e, posteriormente, avaliadas por dois examinadores por meio de instrumentos de avaliação quantitativos e categóricos. RESULTADOS: Todos os parâmetros quantitativos de ambas as modalidades radiográficas apresentaram excelente reprodutibilidade intra e interexaminadores. Dentre os parâmetros categóricos de avaliação da radiografia de cavum, observou-se desempenho relativamente melhor de C-Kurien, C-Wang, C-Fujioka e C-Elwany sobre C-Cohen e C-Ysunza. Em relação aos sistemas destinados à classificação da telerradiografia, C-McNamara apresentou maior reprodutibilidade que C-Holmberg. CONCLUSÃO: A maioria dos instrumentos apresentou reprodutibilidade adequada. No entanto, novas investigações ainda devem ser realizadas com o intuito de determinar a capacidade de cada parâmetro em relação sua acurácia e viabilidade. Abstract in english The assessment of adenoids by x-ray imaging has been the topic of heated debate, but few studies have looked into the reliability of most existing radiographic parameters. OBJECTIVE: This study aims to verify the intra-examiner and inter-examiner reproducibility of the adenoid radiographic assessmen [...] t methods. MATERIALS AND METHODS: This is a cross-sectional case series study. Forty children of both genders aged between 4 and 14 were enrolled. They were selected based on complaints of nasal obstruction or mouth breathing and suspicion of pharyngeal tonsil hypertrophy. Cavum x-rays and orthodontic teleradiographs were assessed by two examiners in quantitative and categorical terms. RESULTS: All quantitative parameters in both x-ray modes showed excellent intra and inter-examiner reproducibility. Relatively better performance was observed in categorical parameters used in cavum x-ray assessment by C-Kurien, C-Wang, C-Fujioka, and C-Elwany over C-Cohen and C-Ysunza. As for orthodontic teleradiograph grading systems, C-McNamara has been proven to be more reliable than C-Holmberg. CONCLUSION: Most instruments showed adequate reproducibility levels. However, more research is needed to properly determine the accuracy and viability of each method.

  8. Radiographic evaluation of adenoidal size in children: methods of measurement and parameters of normality

    International Nuclear Information System (INIS)

    Radiograph of the nasopharynx is still the most commonly used imaging method to investigate the adenoidal tissue. Due to the variety and complexity of proposed methods to measure the adenoid size, some radiologists prefer subjective evaluation, which can, however, be imprecise and inaccurate. We review and describe several methods to determine the adenoid size, taking into account the practicity, accuracy and precision with the aim of pointing out the best methods to be applied in daily routine practice. (author)

  9. Primary Pulmonary Adenoid Cystic Carcinoma Located at the end of the Terminal Bronchiolus: Case Repo

    Directory of Open Access Journals (Sweden)

    Tülin Durgun Yetim

    2012-07-01

    Full Text Available Pulmonary adenoid cystic carcinoma is a rare salivary glandtype malignant neoplasm of respiratory tract that is usually located in the central airways such as trachea and main bronchus. Adenoid cystic carcinoma arising from the peripheral lung is quite rare. Here, we report adenoid cystic carcinoma that developed at the end of the terminal bronchiol of the right lung lower lobe of a 52-year-old woman.

  10. Correlación microbiológica en cultivo de adenoides y glue en pacientes con OME / Microbiological correlation between adenoid and glue ear cultures in patients with OME

    Scientific Electronic Library Online (English)

    Rodrigo, Pinto C; Eduardo, Carmine A; Maritza, Rahal E.

    2012-08-01

    Full Text Available SciELO Chile | Language: Spanish Abstract in spanish Introducción: La otitis media con efusión (OME) sigue siendo la patología otológica más prevalente en los preescolares de Chile; su etiología y factores predisponentes aún no están del todo claro; por ende su tratamiento es controversial. Objetivo: Demostrar una correlación microbiológica en cultivo [...] s de tejido adenoídeo y glue de ambos oídos en pacientes con OME. Material y método: Estudio prospectivo caso/control, donde se analizaron los cultivos bacterianos de tejido adenoideo y glue de ambos oídos en 40 pacientes con OME y cultivos bacterianos de tejido adenoídeo de 40 pacientes con hiperplasia adenoídea sin OME. Resultados: Casos: Cinco cultivos negativos de adenoides (12,5%), 28 positivos a comensales (70%) y 7 positivos a gérmenes no habituales (17,5%). El glue presentó cultivo negativo en 72,5% OD y 77,5% OI. Los cultivos de adenoides en los controles no difieren mayormente a los casos. Discusión: No se pudo establecer una correlación microbiológica entre glue y adenoides en pacientes con OME. Conclusiones: El número de cultivos de glue negativos se correlaciona con la literatura mundial. No existe un patrón que permita correlacionar los cultivos de adenoides de los casos con los cultivos de glue, ni con los cultivos de adenoides de los controles. Abstract in english Introduction: Otitis Media with Effusion is still the most prevalent otological pathology in preschool children in Chile. Its etiology and predisposing factors are not entirely clear yet. Hence, its treatment is controversial. Aim: To demonstrate a microbiological correlation in adenoid tissue and g [...] lue ear cultures in both ears in patients with OME. Material and method: Prospective case control study, which analyzed bacterial adenoid tissue cultures and glue ear cultures in both ears in 40 patients with OME, and a second control group of bacterial cultures in 40 patients with adenoid hyperplasia without ear effusion. Results: Cases: Five negatives in adenoid cultures (12.5%), 28 positive to guest bacteria (70%) and 7 positive at unusual germs (17.5%). The glue ear presented negative culture at 72.5% in the right ear and 77.5% in the left ear. Adenoid control cultures did not differ with OME studied cases. Discussion: A microbiological glue ear and adenoid correlation could not be established. Conclusions: The number of negative glue ear cultures is similar to published literature. There is not a pattern which allows a positive correlation between adenoid cases cultures and glue ear cultures or with control adenoid cultures.

  11. Correlación microbiológica en cultivo de adenoides y glue en pacientes con OME Microbiological correlation between adenoid and glue ear cultures in patients with OME

    Directory of Open Access Journals (Sweden)

    Rodrigo Pinto C

    2012-08-01

    Full Text Available Introducción: La otitis media con efusión (OME sigue siendo la patología otológica más prevalente en los preescolares de Chile; su etiología y factores predisponentes aún no están del todo claro; por ende su tratamiento es controversial. Objetivo: Demostrar una correlación microbiológica en cultivos de tejido adenoídeo y glue de ambos oídos en pacientes con OME. Material y método: Estudio prospectivo caso/control, donde se analizaron los cultivos bacterianos de tejido adenoideo y glue de ambos oídos en 40 pacientes con OME y cultivos bacterianos de tejido adenoídeo de 40 pacientes con hiperplasia adenoídea sin OME. Resultados: Casos: Cinco cultivos negativos de adenoides (12,5%, 28 positivos a comensales (70% y 7 positivos a gérmenes no habituales (17,5%. El glue presentó cultivo negativo en 72,5% OD y 77,5% OI. Los cultivos de adenoides en los controles no difieren mayormente a los casos. Discusión: No se pudo establecer una correlación microbiológica entre glue y adenoides en pacientes con OME. Conclusiones: El número de cultivos de glue negativos se correlaciona con la literatura mundial. No existe un patrón que permita correlacionar los cultivos de adenoides de los casos con los cultivos de glue, ni con los cultivos de adenoides de los controles.Introduction: Otitis Media with Effusion is still the most prevalent otological pathology in preschool children in Chile. Its etiology and predisposing factors are not entirely clear yet. Hence, its treatment is controversial. Aim: To demonstrate a microbiological correlation in adenoid tissue and glue ear cultures in both ears in patients with OME. Material and method: Prospective case control study, which analyzed bacterial adenoid tissue cultures and glue ear cultures in both ears in 40 patients with OME, and a second control group of bacterial cultures in 40 patients with adenoid hyperplasia without ear effusion. Results: Cases: Five negatives in adenoid cultures (12.5%, 28 positive to guest bacteria (70% and 7 positive at unusual germs (17.5%. The glue ear presented negative culture at 72.5% in the right ear and 77.5% in the left ear. Adenoid control cultures did not differ with OME studied cases. Discussion: A microbiological glue ear and adenoid correlation could not be established. Conclusions: The number of negative glue ear cultures is similar to published literature. There is not a pattern which allows a positive correlation between adenoid cases cultures and glue ear cultures or with control adenoid cultures.

  12. Carcinome épidermoïde de l’urètre masculin révélé par une rupture spontanée de l’urètre

    Science.gov (United States)

    Ghorbel, Jilani; Hafsia, Ghassen; Derouiche, Amine; Jrad, Anis; Chebil, Mohamed

    2011-01-01

    Résumé Le carcinome épidermoïde de l’urètre masculin est une tumeur rare, les tumeurs de l’urètre tous types confondus représentant moins de 1 % des tumeurs de l’appareil urinaire. Le pronostic reste défavorable malgré un traitement chirurgical énergique. La radiochimiothérapie semble être un traitement prometteur, mais son rôle doit être défini par d’autres études. Nous rapportons un cas rare de carcinome épidermoïde de l’urètre bulbo-membraneux découvert à un stade localement avancé après observation d’une rupture urétrale transtumorale chez un homme âgé de 70 ans. Le patient a été traité, après drainage vésical, par une irradiation externe associée à une chimiothérapie par cisplatine, et est décédé après progression de la maladie sur un an. La rupture spontanée de l’urètre transtumorale est un mode de découverte exceptionnel témoignant d’une évolution locale défavorable, ce qui rend ces tumeurs difficilement opérables. Cependant, l’espoir actuel réside dans des protocoles thérapeutiques associant radiothérapie et chimiothérapie. PMID:21672490

  13. Adenoid cystic carcinoma of the minor salivary glands

    International Nuclear Information System (INIS)

    Adenoid cystic carcinoma is a malignant salivary gland tumor with typical histologic patterns. The majority of the se tumors occurs in the minor salivary glands, especially mucosa of the hard palate. The authors experienced the patients, who complained the tumor-like soft tissue masses on the palatal and mouth floor area. After careful analysis of clinical, radiological and histopathological findings, we diagnosed them as adenoid cystic carcinomas in the minor salivary glands, obtained results were as follows : 1. Main clinical symptoms were a slow growing soft tissue mass with normal intact mucosa on the palatal area, and soft tissue mass with mild pain on the mouth floor area. 2. In the radiographic examinations, soft tissue masses were observed with invasion to adjacent structures, and moderate defined, heterogeneous soft tissue mass with enhanced margin, respectively. 3. In the histopathologic examinations, dark-stained, small uniform ballad's cells in the hyaline or fibrous stroma were observed as solid and cribriform patterns, respectively.

  14. Adenoid-cystic carcinoma (cylindroma) of the trachea

    International Nuclear Information System (INIS)

    Nine patients with an adenoid-cystic carcinoma of the trachea are described. It is a rare tumour which grows relatively slowly; it has a tendency for early invasion of neighbouring tissues, but late distant metastases. A correct diagnosis can be made by the radiologist. The trachea should be visible on every film of the thorax and should be inspected. In particular, a diagnosis of therapy-resistent asthma should direct the attention of the radiologist to the trachea. (orig.)

  15. Relative etiological importance of adenoid hypertrophy versus sinusitis in children with persistent rhinorrhoea.

    Science.gov (United States)

    Maheswaran, S; Rupa, V; Ebenezer, Jareen; Manoharan, Anand; Irodi, Aparna

    2015-03-01

    Persistent rhinorrhoea is a common, yet often neglected, problem among Indian children. This study was designed to evaluate the relative etiological importance of adenoid hypertrophy versus sinusitis in children with persistent rhinorrhea. Additionally, the association between S. pneumoniae colonization and adenoid hypertrophy was studied. Children aged 1-14 years with persistent rhinorrhea underwent clinical evaluation, rigid nasal endoscopy and xrays of the nasopharynx and paranasal sinuses to ascertain the presence of adenoid hypertrophy and sinusitis using standard criteria. Nasopharyngeal swabbing to ascertain the presence of nasopharyngeal colonization with S. pneumoniae was also performed. Adenoid hypertrophy was more consistently associated with persistent rhinorrhea than sinusitis (p sinusitis occurred in 57 %. S. pneumoniae was cultured in only 29 % of children. Up to 47 % of patients had features of nasal allergy. There was no association between S. pneumoniae colonization and adenoid hypertrophy (p = 0.1). Adenoid hypertrophy is an important cause of persistent rhinorrhea in children. Measures to evaluate for and treat adenoid hypertrophy should be instituted early to alleviate the problem of persistent rhinorrhoea in children. S. pneumoniae colonization of the nasopharynx is not a major etiological factor for persistent rhinorrhoea in these children. Nasal allergy may be a cause of adenoid hypertrophy in roughly half the children. PMID:25621229

  16. Association rare d'un adenome pleomorphe et d'un carcinome epithelial myoepithelial de la glande parotide

    OpenAIRE

    Jahidi, Ali; Hemmaoui, Bouchaib; Noureddine, Errami; Youssef, Darouassi; Issam, Rharrasi; Hafsa, Chahdi; Benariba, Fouad

    2014-01-01

    Le Carcinome épithélial - myoépithélial (CEM) est une tumeur maligne rare des glandes salivaires touchant principalement la glande parotide. Son association avec un adénome pléomorphe est exceptionnelle. Nous rapportons le cas d'une femme de 57 ans avec adénome pléomorphe de la glande parotide évoluant depuis plusieurs années. L'augmentation récente du volume de la glande associée à l'apparition d'adénopathies cervicales homolatérales nous a fait penser à une transformation ma...

  17. Adenoid cystic carcinoma — Clinical presentation and cytological diagnosis

    OpenAIRE

    Dutta, N. N.; Baruah, R.; Das, L.

    2002-01-01

    Adenoid cystic carcinoma is a tumor arising from the minor salivary glands, the palate being the commonest site. It accounts for about 1% of all head and neck malignancies. We report a case with the typical presentation of a palatal growth with extensive intra-cranial invasion. The diagnosis of this case and a brief review of literature is discussed. Final diagnosis of this case was made from cytological reports. The dry smears stained with MGG were found to be definitely superior to the alco...

  18. The CT evaluation of cephalic and cervical adenoid cystic carcinoma

    International Nuclear Information System (INIS)

    Objective: To evaluate the CT manifestations of cephalic and cervical adenoid cystic carcinoma (ACC). Methods: Thirty-three cases of ACC were analyzed retrospectively. Of all cases, 22 cases underwent operation and 11 cases received radiotherapy. The manifestations of CT were evaluated and compared with the clinical and pathologic results. Results: Tumors originated from parotid gland (5 cases), floor of mouth (5 cases), nasal cavity and nasopharynx (5 cases), tongue (4 cases), palate (3 cases), tracheas (3 cases), submandibular gland (2 cases), tonsilla (2 cases), maxillary sinus (2 cases), and cheek (2 cases), respectively. The CT manifestations included: (1)ethmoid density in 21 cases, partial ethmoid density in 5 cases. (2)the morphology of ACC was irregular and the growth of the tumor was amorphous in 17 cases, and the margin of the tumor was vague in 20 cases. (3)ACC often grew along the nerve with infiltration, which caused destruction of the skull base in 5 cases and atrophy of mastication muscles and/or buccinator in 3 cases. Conclusion: (1)The characteristics of cephalic and cervical adenoid cystic carcinoma on CT scans were ethmoid density, infiltrated growth, growing along the nerve with infiltration, and submucous growth. Among them, the most important manifestation, which could lead to the histologic diagnosis on CT, was ethmoid density. (2)The range of ACC was usually underestimated on CT. (3)The manifestation of tumor growth along the nerve could be apf tumor growth along the nerve could be apparently displayed on MRI

  19. Adenoid cystic carcinoma of the minor salivary glands

    Energy Technology Data Exchange (ETDEWEB)

    Kwon, Kyung Yun; Lee, Kyung Ho; Kim, Dong Youn; Choi, Karp Shik [Dept. of Dental Radiology, College of Dentistry, Kyungpook National University, Daegu (Korea, Republic of)

    1997-02-15

    Adenoid cystic carcinoma is a malignant salivary gland tumor with typical histologic patterns. The majority of the se tumors occurs in the minor salivary glands, especially mucosa of the hard palate. The authors experienced the patients, who complained the tumor-like soft tissue masses on the palatal and mouth floor area. After careful analysis of clinical, radiological and histopathological findings, we diagnosed them as adenoid cystic carcinomas in the minor salivary glands, obtained results were as follows : 1. Main clinical symptoms were a slow growing soft tissue mass with normal intact mucosa on the palatal area, and soft tissue mass with mild pain on the mouth floor area. 2. In the radiographic examinations, soft tissue masses were observed with invasion to adjacent structures, and moderate defined, heterogeneous soft tissue mass with enhanced margin, respectively. 3. In the histopathologic examinations, dark-stained, small uniform ballad's cells in the hyaline or fibrous stroma were observed as solid and cribriform patterns, respectively.

  20. Carcinoma adenoide quístico parotídeo: soluciones estéticas y funcionales / Adenoid Cystic Carcinoma of the Parotid: an Aesthetic and Functional Solutions

    Scientific Electronic Library Online (English)

    Raquel, Villar; Manuel, Acosta; Benito, Ramos; Juan José, Haro; Antonio, Gómez; Tomás, Esteban; Ramsés, Caraballo.

    2014-09-01

    Full Text Available El carcinoma adenoide quístico supone el 10-30% de las neoplasias malignas parotídeas, su tratamiento se basa en una parotidectomía que incluya el tumor con un adecuado margen de seguridad y la radioterapia postoperatoria dado que permite mejorar el control locorregional de la enfermedad. Revisamos [...] un caso que permite exponer el manejo de las secuelas funcionales y estéticas derivadas de su tratamiento. Consideramos adecuada la reconstrucción inmediata del nervio facial cuando se encuentra clínicamente afecto o englobado por el tumor; así como suplir el defecto de volumen posparotidectomía con un colgajo local. Proponemos la anastomosis nerviosa con injerto de nervio sural de las ramas del nervio facial afectas y el relleno del defecto volumen posparotidectomía con un colgajo de fascia temporo-parietal. Abstract in english Adenoid cystic carcinoma represents 10-30% of all malignant neoplasms in the parotid gland. Treatment is a formal parotidectomy, which includes removing the tumour with an adequate margin and postoperative radiotherapy to improve the locoregional control of the disease. We report a case in order to [...] present the management of the functional and aesthetic consequences obtained from its treatment. When the facial nerve is clinical affected or involved by the tumour, it requires resection and an immediate reconstruction. We suggest the sural nerve graft for the reconstruction of the affected facial branches and the temporo-parietal fascia flap to fill the volume left by the parotidectomy.

  1. Adenoid cystic carcinoma of the lacrimal gland : MYB gene activation, genomic imbalances, and clinical characteristics

    DEFF Research Database (Denmark)

    von Holstein, Sarah L; Fehr, André

    2013-01-01

    To investigate genetic alterations in lacrimal gland adenoid cystic carcinomas (ACCs) with emphasis on the MYB-NFIB fusion oncogene and its downstream targets, MYB rearrangements, and copy number alterations in relation to clinical data and survival.

  2. Adenoid cystic carcinoma of palate: A case report and review of literature

    Science.gov (United States)

    Chundru, Naga Sirisha Venkata; Amudala, Rajesh; Thankappan, Prasanth; Nagaraju, Chandan Dasa

    2013-01-01

    Adenoid cystic carcinoma is an uncommon, slow growing malignant salivary gland tumor that is characterized by wide local infiltration, perineural spread, propensity to local recurrence and distant metastasis. In this paper, the authors present a case of adenoid cystic carcinoma affecting the palate and involving the maxillary sinus in a 60-year-old male patient along with a brief review of literature. PMID:23946749

  3. Adenoid Cystic Carcinoma of the Lung with Bilateral Renal Metastases at Presentation in a Young Female

    OpenAIRE

    Arpita Banerjee; Ankan Bandyopadhyay; Debraj Jash; Kaushik Saha

    2011-01-01

    Adenoid cystic carcinoma of the lung is a relatively rare, slow growing lung neoplasm. Metastases outside the lung are uncommon. Herein, we have reported the case of a patient who presented with a large mass in the right lower lobe of her lung. Bronchial biopsy revealed features suggestive of adenoid cystic carcinoma of thelung with a predominant cribriform architecture. CT abdomen showed features of bilateral renal and liver metastases, but no adrenal metastases.

  4. Radiographic evaluation of adenoidal size in children with allergic perennial rhinitis: still the current method

    International Nuclear Information System (INIS)

    Adenoid hypertrophy is known to be the most common cause of nasal obstruction in children; thus, adenoidectomy is one of the most commonly performed surgical procedures in children. Clinical assessment of adenoidal size is difficult, and objective measurement is desirable. The study included 39 children (17 girls and 22 boys, 5-9 years of age, mean age: 6.7 years) with signs of perennial allergic rhinitis and suspicion of adenoidal hypertrophy. To establish the best radiological method to measure the adenoidal size, three different procedures (Johanneson, Fuijoka, and Cohen/Konak) were used. The methods were evaluated against the degree to which the adenoids obstructed the nasopharyngeal space on flexible endoscopy of the postnasal space. Clinical symptomatology was also evaluated against the degree of obstruction. To estimate the correspondence between the results, we used Spearman's correlation test.The radiological method that best correlated with the endoscopic findings was that of Cohen and Konak, but neither radiology nor endoscopic scores correlated well with clinical symptoms. Conclusion: The side-adenoid assessment in allergic children. (author)

  5. Adenoid carcinoma cystic of trachea. A case report

    International Nuclear Information System (INIS)

    The tumours of trachea are not frequent. Within them, the adenoid carcinoma cystic is a rare malign tumour and it has been demonstrated that it does not relate to each other significant whit tobacco addiction. In this work we present the case of female patient of 45 years old who went to the urgency room with out of breath accompanied of humid cough with greenish abundant expectoration, fever to 39C and loss of 6 heavy kg in 6 months. The X-ray of thorax sold off in service of urgencies was normal and the doctors imposed treatment no obtaining answer to him. Computerized tomography scanner was made showing the presence of a tracheal lesion

  6. [Adenoid cystic carcinoma of the breast--a case report].

    Science.gov (United States)

    Hayashi, I; Katsuda, Y; Nomura, Y; Tashiro, H

    1983-08-01

    We report a rare case of adenoid cystic carcinoma (ACC) of the breast. The patient was a 60-year-old female with a lump of the left breast which had present for 20 years. Macroscopically, the resected left breast tumor was well defined, 7.5 X 7 X 5 cm in size, oval shaped, yellowish gray-white and solid, parts of the tumor showed cystic appearance. Microscopic study revealed a cribriform pattern and alveolar proliferation of uniform, small cells forming cysts, and duct-like spaces which contained mucous content. Each tumor nest was surrounded by hyaline stroma. Alcian blue-PAS staining showed that the cysts were alcian blue-positive; the ducts were PAS-positive. The tumor was diagnosed as ACC of the breast. PMID:6312120

  7. Adenoid Cystic Carcinoma Mimicking an Oroantral Fistula: A Case Report

    Scientific Electronic Library Online (English)

    Bárbara Vanessa de Brito, Monteiro; Rafael Grotta, Grempel; Daliana Queiroga de Castro, Gomes; Gustavo Pina, Godoy; Márcia Cristina da Costa, Miguel.

    2014-04-01

    Full Text Available Introduction Adenoid cystic carcinoma (ACC) is one of the most frequent malignant salivary gland tumors, which commonly affects the minor salivary glands of the mouth and is rare in the nose and paranasal sinuses. In the maxillary sinus, ACC can mimic inflammatory diseases and has a poor prognosis [...] . Objective To report a case of a 50-year-old man with ACC of the maxillary sinus whose clinical findings in the alveolar ridge mimicked an oroantral fistula. Case Report An excisional biopsy was performed and histopathologic analysis revealed ACC. Lung metastases and residual tumor in the maxillary sinus were detected by imaging methods. In view of the poor general health of the patient, no new surgical intervention was performed and he was only treated by radiotherapy and follow-up. Conclusion Although rare in the maxillary sinus, ACC should be included in the differential diagnosis of lesions affecting this site.

  8. Radiological features of adenoid cystic carcinoma of the uterine cervix

    Energy Technology Data Exchange (ETDEWEB)

    Kaku, Ayumi; Kiyosue, Hiro; Matsumoto, Shunro; Mori, Hiromu [Oita University Faculty of Medicine, Department of Academic Radiology, Oita (Japan); Kashima, Kenji [Oita University Faculty of Medicine, Department of Pathology, Oita (Japan); Miyakawa, Isao [Oita University Faculty of Medicine, Department of Gynecology, Oita (Japan)

    2005-05-01

    Adenoid cystic carcinoma (ACC) of the uterine cervix is a rare primary neoplasm of the uterus that occurs in post-menopausal women; its radiological findings have not been described previously. We present the MR findings of a case of ACC. The mass exhibited homogeneous low-signal intensity on T1-weighted images. On T2-weighted images, the mass showed high-signal intensity with a lobulated contour and multiple septum-like internal architectures. It also contained spots of very high-signal intensity, which would represent the mucin in the glandular lumen. The multiple septum-like internal architectures probably represented interglandular fibrous stroma. These MRI findings may be helpful for future diagnoses of ACC of the uterine cervix. (orig.)

  9. Adenoid cystic carcinoma of sublingual glands. Surgery and radiotherapy combination

    International Nuclear Information System (INIS)

    The Adenoid Cystic Carcinoma (ACC) or Cilindroma is a strange entity classified by the WHO within the carcinomas of salivary glands. It represents only 1 % of all the wicked tumours of the oral and maxillofacial region although, when making reference to the salivary glands, it constitutes 5% of the parotid, submaxilar and sublingual carcinomas, and about 50% of the smallest ones. The most frequent location is in the palatine glands and its main characteristics are: slow but persistent growth, high rates of local relapse and metastasis at distance originating the death between the first 5 and 10 years in 50-70% of the cases approximately. A case of localization is presented in sublingual gland which was first treated surgically and later with radiotherapy, obtaining good results. (author)

  10. Adenoid cystic carcinoma intermingled with ductal carcinoma of the breast: a case report and review of the literature

    OpenAIRE

    Petrou Athanasios; Karles Dimitrios; Kontos Michael; Th, Alexandrou Paraskevi

    2011-01-01

    Abstract Introduction Adenoid cystic cancer of the breast is a rare condition, and even rarer are the cases where it is histologically mixed with other variants of cancer within a single lesion. In this report, one of the few cases of mixed adenoid cystic breast cancer intermingled with the infiltrating ductal variant is presented. A subsequent review of the relevant literature presents the existing experience in treating mixed breast cancers with adenoid cystic components with regard to diag...

  11. Cutaneous Adenoid Cystic Carcinoma with Perineural Invasion Treated by Mohs Micrographic Surgery—A Case Report with Literature Review

    OpenAIRE

    Xu, Yaohui G.; Hinshaw, Molly; Longley, B. Jack; Ilyas, Humza; Snow, Stephen N.

    2010-01-01

    We report a 58-year-old woman with cutaneous adenoid cystic carcinoma arising on the chest treated with Mohs micrographic surgery. The patient remained tumor-free at 24-month follow-up. To date, only six other cases of cutaneous adenoid cystic carcinoma were reportedly managed by Mohs surgery. Cutaneous adenoid cystic carcinoma has low potential for distant metastasis but is notorious for its aggressive infiltrative growth pattern, frequent perineural invasion, and high risk of local recurren...

  12. Evaluation of the relation between adenoids hypertrophy and cranial base angles

    Directory of Open Access Journals (Sweden)

    Dalili Z

    2006-07-01

    Full Text Available Background and Aim: Adenoids are normally large in children and their size starts to reduce during adolescence. Hypertrophic adenoids could be associated with allergic reactions. Enlarged adenoids result in nasal breathing difficulties and the child is forced to switch to mouth breathing. Airway obstruction causes postural alterations of jaw, tongue and head, and due to persistent obstruction, patient’s appearance changes to adenoid face. Evaluation of nasopharyngeal space in lateral cephalometic view is a simple and repeatable method for determination of the size and shape of adenoids and nasopharyngeal space which can provide a simple measurement of nasopharyngeal obstruction. The roof of nasopharyngeal space is covered by the sphenoid bone. Thus changes of nasorespiratory resistance by hypertrophic adenoids may affect the cranial base angles. In this study, the relationship between adenoid hypertrophy and cranial base angles was investigated. Materials and Methods: In this descriptive-analytic study, lateral cephalometric views of 7 to 14 y/o patients from the files of orthodontic centers in Rasht city were selected. The radiographs with proper resolution were separated for this research. Adenoid to nasorespiratory ratio (A/N Ratio was determined by Fujioka method and categorized in three groups: A (A/N 0.8, B (0.5adenoid hypertrophy (A and B groups was observed in 66% of cases whereas 34% were normal. The frequency of narrow, normal and wide cranial base angles in lateral ceph views was 28%, 30% and 42% respectively. There was significant difference among different cranial base angle regarding the presence or absence of adenoid hypertrophy (P<0.001. According to Pearson coefficient, there was significant relation between A/N ratio groups and different cranial base angles (R=0.2. Conclusion: Based on the results of this study, little correlation exists between A/N ratio and cranial base angle. Further studies are recommended to investigate the possible effects of other factors such as genetics and the environment.

  13. Adenoid cystic carcinoma of the lacrimal gland metastasising to the liver: report of a case

    Directory of Open Access Journals (Sweden)

    Pearce Neil W

    2006-09-01

    Full Text Available Abstract Background Adenoid Cystic Carcinoma of the lacrimal gland is a rare tumour. Their aggressive behaviour, with a high-risk of local recurrence, and late distant spread of the tumour even after aggressive management has been reported. Metastasis to the liver is rare and when it occurs, it is usually part of widespread metastasis, and therefore surgical treatment is seldom considered. Case presentation We report a rare case of an isolated liver metastasis from a lacrimal gland adenoid cystic carcinoma 20 years after resection of the primary tumour. The patient presented with right upper quadrant pain radiating to the back and shortness of breath of 3 months duration. No local recurrence was detected during a 15 year follow-up with computerized tomography (CT of the head. Abdominal CT scan demonstrated a solitary liver tumour with no other primary source, and the bone scan was normal. The patient was treated with an extended right hemihepatectomy. The histology revealed a predominantly cribriform tumour with focal areas of basaloid type metastatic lacrimal gland adenoid cystic carcinoma. Conclusion This case illustrates the unpredictable behaviour of adenoid cystic carcinoma and the need for a life long follow up for these patients after treatment. The possibility of surgical resection for liver metastasis from adenoid cystic carcinoma should always be considered.

  14. The value of radiological examination in the management of adenoidal hypertrophy in a pediatric population

    International Nuclear Information System (INIS)

    The objective of this study is to evaluate the role of radiological examination in the management of adenoidal hypertrophy. A retrospective study was carried out in the North West Armed Forces Hospital, Tabuk, Kingdom of Saudi Arabia on pediatric patients who had x-ray of lateral nasopharynx to exclude adenoidal hypertrophy, January 2001 to December 2001. The study included ; the age of patient, sex and reason for radiology examination and management rendered. A total of two hundred and ninety- seven pediatric patients were involved. Two hundred and thirteen males (71.7%) and 84(28.3%) females, age ranged between 2 months and 12 years. The reason given for radiological examination was one or more of following symptoms snoring,mouth breathing recurrent tonsillitis, runny nose, deafness and obstructive sleep apnea.Small adenoids reported in 63 patients (21.2%)and were treated for their complaints by primary physician. Two hundred and thirty four patients (78.8%) with large adenoids were referred to the otolaryngology department of these 33 patients lost follow up. One hundred and nineteen referred(40.1%) patients were treated conservatively, while 82 patients (27.6%) who showed resistance to medical treatment under went adeniodectomy with or without other related surgical procedures. It was concluded that radiological examination in the management of adenoidal hypertrophy had a limited role, increased Radiological Department workload wastage of resources in addition to kload wastage of resources in addition to unnecessary radiation exposure. (author)

  15. Radiologic evaluation of adenoids and tonsils in children with obstructive sleep apnea: Plain films and fluoroscopy

    International Nuclear Information System (INIS)

    Twenty-six children with obstructive sleep apnea were evaluated by lateral neck radiographs during wakefulness, and by polygraphic monitoring and upper airway fluoreoscopy during natural sleep. Children with craniofacial abnormalities, palatal surgery, and central nervous system disease were excluded from the study. Moderate or marked enlargement of tonsils and adenoids was noted on lateral neck radiographs of 18 of 26 patients. An objective measure of adenoidal enlargement, the adenoidal-nasopharyngeal ratio, correlated well with subjective judgment of adenoidal size but was not generally more useful than subjective estimation. Upper airway fluroescopy demonstrated the site and mechanism of obstruction in all patients. Because all children with moderate to marked adenotonsillar enlargement demonstrated obstruction at the adenoidal or tonsillar level on fluoroscopy, we now screen children with suspected sleep apnea with lateral airway radiographs and polysomnography. Fluoroscopy is reserved for children with mild adenotosillar enlargement, craniofacial dysplasia, prior cleft palate repair, or neuromuscular disorders. These results suggest that the pathogenesis of obstuctive sleep apnea in children involve anatomic factors which narrow the upper airway, sleep-related hypotonia of pharyngeal dilator musculature, and compensatory mechanisms to prevent or alleviate asphyxia. (orig.)

  16. Radiologic evaluation of adenoids and tonsils in children with obstructive sleep apnea: Plain films and fluoroscopy

    Energy Technology Data Exchange (ETDEWEB)

    Kreplick Fernbach, S.; Brouillette, T.; Riggs, T.W.; Hunt, C.E.

    1983-07-01

    Twenty-six children with obstructive sleep apnea were evaluated by lateral neck radiographs during wakefulness, and by polygraphic monitoring and upper airway fluoreoscopy during natural sleep. Children with craniofacial abnormalities, palatal surgery, and central nervous system disease were excluded from the study. Moderate or marked enlargement of tonsils and adenoids was noted on lateral neck radiographs of 18 of 26 patients. An objective measure of adenoidal enlargement, the adenoidal-nasopharyngeal ratio, correlated well with subjective judgment of adenoidal size but was not generally more useful than subjective estimation. Upper airway fluroescopy demonstrated the site and mechanism of obstruction in all patients. Because all children with moderate to marked adenotonsillar enlargement demonstrated obstruction at the adenoidal or tonsillar level on fluoroscopy, we now screen children with suspected sleep apnea with lateral airway radiographs and polysomnography. Fluoroscopy is reserved for children with mild adenotosillar enlargement, craniofacial dysplasia, prior cleft palate repair, or neuromuscular disorders. These results suggest that the pathogenesis of obstuctive sleep apnea in children involve anatomic factors which narrow the upper airway, sleep-related hypotonia of pharyngeal dilator musculature, and compensatory mechanisms to prevent or alleviate asphyxia.

  17. Laryngeal Preservation in Managing Advanced Tracheal Adenoid Cystic Carcinoma

    Science.gov (United States)

    Subramaniam, Thavakumar; Lennon, Paul; Kinsella, John; O'Neill, James Paul

    2015-01-01

    A 37-year-old male athlete was diagnosed with primary tracheal adenoid cystic carcinoma following investigation for dyspnea, wheeze, and eventual stridor. Preoperative bronchoscopy revealed a highly vascular tumor 4?cm distal to the cricoid with no gross disease extending to the carina. Imaging revealed circumferential tracheal irregularity immediately inferior to the cricoid, with no definite cricoid invasion. Locoregional extension of disease was noted invading the thyroid and abutment of the carotid approximately 180°. Intraoperative findings identified tracheal mucosal disease extending distal to the carina and proximally at the cricothyroid joints where bilateral functional recurrent nerves were preserved. A decision made to preserve the larynx given the inability to fully resect distal tracheal disease. A 5?cm sleeve resection of the trachea was made with a cricotracheal anastomosis following suprahyoidal muscle release and laryngeal drop-down. The patient was treated with adjuvant radiotherapy including platinum based chemotherapy in an effort to maximise local control. PET scanning three months after therapy revealed no FDG uptake locally or distally. PMID:25878915

  18. Clinical study of adenoid cystic carcinoma of the parotid gland

    International Nuclear Information System (INIS)

    We report results of a retrospective study of 12 cases of adenoid cystic carcinoma (ACC) in the parotid gland. Local pain was often observed in ACC among other malignant parotid tumors. Although fine-needle aspiration cytology (FNA) was not effective for preoperative diagnosis, frozen section diagnosis (FS) during surgery showed excellent results. Cases with T3 or T4 underwent total or enlarged parotidectomy, but, often showed positive surgical margins. Postoperative radiation therapy seemed useful in these cases and the 5- and 10- year disease-specific survivals in these 12 cases were 90.0% and 80.8%. These compare favorably with other reports in the literature. All 12 cases showed N0 and no cervical relapse with or without neck dissection, indicating little effectiveness in prophylactic neck dissection. Tumor size, positive surgical margins, and perineural invasion are risk factors for this tumor as mention previously. Patients with perineural invasion, especially preoperative facial nerve palsy (T4a), are more likely to fail than those with two other factors, so, it seems conceivable for cases of T4a to undergo more positive treatment with surgery and postoperative radiation. (author)

  19. Adenoid cystic carcinoma of the head and neck

    Energy Technology Data Exchange (ETDEWEB)

    Ishinaga, Hajime; Harada, Teruhiko; Yuta, Atsushi; Kobayashi, Masayoshi; Majima, Yuichi [Mie Univ., Tsu (Japan). School of Medicine

    2001-03-01

    Between 1976 and 1999, 10 patients with adenoid cystic carcinoma of the head and neck were treated in our department. The patients consisted of 20 females and 20 males. The overall 5-year and 10-year survival rates determined, by Kaplan-Meier analysis, were 74.8% and 47.4%, respectively. The 10-year survival rate of stage I-II was 75.0%, and that of stage III-IV was 33.6%. The prognosis of the patients with stage III-IV was relatively poor. The 10-year survival rates of the patients with nasal and paranasal tumors, and those with maxillary sinus tumors were 25.0% and 0%, respectively. The 10-year survival rate of 15 patients that received combined surgery and radiotherapy was 44.0%, while that of 21 patients that received surgery alone was 48.6%. There was no statistical significance between the two. It was effective, for the patients with lung metastases, to perform pulmonary surgery, for progmosis improvement. We concluded that obtaining clear margins at the initial surgery appeared to be associated with improved survival, combined radiation of less than 50 Gy was not effective, patients with pulmonary metastasis should be treated, if possible. (author)

  20. Adenoid Cystic Carcinoma– A rare Differential Diagnosis for a mass in the External Auditory Canal

    Science.gov (United States)

    Shenoy, Vijendra S; Rao, Raghavendra A; Kamath, Panduranga M; Shihab, Haseena

    2015-01-01

    Primary external auditory canal malignancies are very rare; in which, adenoid cystic carcinoma is extremely rare tumour accounting for approximately 5%. Majority of the patients presents with unilateral severe or dull aching constant ear pain of prolonged duration, reduced hearing and mass in the External Ear. These tumours are treated with aggressive surgical excision and adjuvant radiotherapy. Despite this, the overall prognosis is poor due to recurrences and distant metastasis. We report a rare case of adenoid cystic carcinoma in a 36-year-old female, who presented with right ear pain for the last one year. She was treated with wide local excision of the mass followed by adjuvant radiotherapy. PMID:25738012

  1. Discovery of invasion routes for nasopharyngeal adenoid cystic carcinoma.

    Science.gov (United States)

    Dong, Jun; Zhang, Liang; Mo, Yunxian; Tian, Li; Liu, Lizhi; Wu, Peihong

    2015-01-01

    The aim of this study is to discover regional invasion routes for nasopharyngeal adenoid cystic carcinoma (NACC) through analyses of the magnetic resonance (MR) images and comparison with keratinizing squamous cell carcinoma (KSCC). Both MR results and clinical records were retrospectively reviewed for 18 patients with NACC and 182 patients with KSCC. The metastasis routes of NACC were identified by analysis of MR images of patients who underwent magnetic resonance imaging (MRI). There were significant differences in skull base invasion and cavernous sinus invasion (p = 0.020 and 0.028, respectively) while parapharyngeal space invasion rate was not. The laryngopharynx invasion rate and external pterygoid muscle invasion rate were higher in NACC patients than that in KSCC patients (16.7% vs. 0.5 %, p = 0.002; 27.8% vs. 11.0%, p = 0.040, respectively). Paralysis of the cranial nerves had a significant higher incidence in the NACC group compared to the KSCC group (66.7% vs. 8.2%, p < 0.001). There was significant difference in invasion to the neural foramen between the NACC and KSCC groups (66.7% vs. 36.3%, p = 0.020). Foramen ovale was a common invasion site, significantly higher in NACC patients than in KSCC patients (50.0% vs. 24.1%, p = 0.018). Based on the MRI findings, a regional invasion model of NACC with two possible routes has been built, including aggressive local infiltration along submucosa to laryngopharynx or external pterygoid muscle, and extension from pharyngonasal cavity, through cranial nerve canal to cavernous sinus. The significant difference in overall survival (OS) time between the two different invasion routs and the recurrent rates in different regions also supported the validity of the invasion model. PMID:25553093

  2. Métastase musculaire d'un carcinome épidermoide du col utérin: à propos d'un cas avec revue de la littérature

    Science.gov (United States)

    Mezouri, Imane; Chenna, Hanane; Bellefqih, Sara; ElKacemi, Hanan; Kebdani, Tayeb; Benjaafar, Noureddine

    2014-01-01

    Les métastases musculaires sont rares, leur nombre est probablement sous estimé. Nous rapportons le cas d'une patiente âgée de 65 ans, ayant présenté une métastase musculaire d'un carcinome épidermoïde du col utérin 6 mois après le diagnostic de la tumeur primitive. Le diagnostic a été obtenu à partir de la biopsie et du scanner abdomino-pelvien. Le traitement a consisté en une irradiation palliative à la dose de 30Gy. L’évolution a été marquée par le décès de la patiente. A travers ce cas clinique on a démontré que le muscle peut être touché par les métastases d'un carcinome épidermoïde du col utérin et que leur pronostic reste en général péjoratif. PMID:25368712

  3. Primary adenoid cystic carcinoma in larynx and upper part of trachea

    International Nuclear Information System (INIS)

    The aim of this study is presentation of 2 cases primary adenoid cystic carcinoma in subglottic part larynx and upper part trachea. Both were treated by surgical resection with following radiotherapy. Observation period in one case without any recurrens signs and neoplasmatic dissemination is 16 years. (author)

  4. THE PRESENCE OF ADENOID VEGETATIONS AND NASAL SPEECH, AND HEARING LOSS IN RELATION TO SECRETORY OTITIS MEDIA

    Directory of Open Access Journals (Sweden)

    Gabriela KOPACHEVA

    2004-12-01

    Full Text Available This study presents the treatment of 68 children with secretory otitis media. Children underwent adenoid vegetations, nasal speech, conductive hearing loss, ventilation disturbance in Eustachian tube. In all children adenoidectomy was indicated.38 boys and 30 girls at the age of 3-17 were divided in two main groups: * 29 children without hypertrophic (enlarged adenoids, * 39 children with enlarged (hypertrophic adenoids.The surgical treatment included insertion of ventilation tubes and adenoidectomy where there where hypertrophic adenoids.Clinical material was analyzed according to hearing threshold, hearing level, middle ear condition estimated by pure tone audiometry and tympanometry before and after treatment. Data concerning both groups were compared.The results indicated that adenoidectomy combined with the ventilation tubes facilitates secretory otitis media heeling as well as decrease of hearing impairments. That enables prompt restoration of the hearing function as an important precondition for development of the language, social, emotional and academic development of children.

  5. Adenoid cystic carcinoma of the head and neck: A retrospective series of 169 cases

    International Nuclear Information System (INIS)

    Purpose. - Adenoid cystic carcinoma represents 1% of head and neck cancers. Adenoid cystic carcinomas are slow growing tumours with high potential for local recurrence. Treatment usually associates radiotherapy and surgery, but the role of radiotherapy remains unclear. We report a retrospective multicentric study of the management and prognostic factors of 169 adenoid cystic carcinomas of head and neck. Patients and methods. - Between 1982 and 2010, 169 patients with adenoid cystic carcinoma of the head and neck were referred to the Cercle des oncologues radiotherapeutes du Sud departments of radiotherapy either for primary untreated tumour (n = 135) or for a recurrence of previously treated tumour (n = 34). The site of adenoid cystic carcinoma was: parotid gland (n = 48, 28.4%), minor salivary gland (n = 35, 20.7%), submandibular gland (n = 22, 13%), sinus cavities (n = 22, 13%), other (n = 42, 24.9%). Tumour stages were: T1 (12.4%); T2 (14.2%); T3 (12.4%); T4 (41.4%) and Tx (19.5%). Lymph node involvement was 13% and distant metastasis 8.9%. For adenoid cystic carcinomas of the parotid gland, major nerve involvement was evaluated. Preferential site of metastasis was the lung (87.5%). Treatments were: surgery alone (n = 27), surgery and adjuvant radiotherapy (n = 89), surgery and adjuvant chemoradiotherapy (n 12), exclusive chemoradiotherapy (n = 13), exclusive radiotherapy (n = 14), other associations (n = 5) and no treatment (n = 7). Radiotherapy was delivered throt (n = 7). Radiotherapy was delivered through photons (n = 119), neutrons (n = 6), both (n = 4). Two patients had a brachytherapy boost. Median prescribed doses to T and N were respectively 65 Gy and 50 Gy for the 119 photons treated patients. Results. - Mean follow-up was 58 months (range 1-250 months). As of December 1, 2010, 83 patients were alive with no evolutive disease (49%), 35 alive and had recurred, 18 had uncontrolled evolutive disease, 28 had died of adenoid cystic carcinoma and 5 of intercurrent disease. Overall survival and disease free survival were respectively 72% and 72% at 5 years, 53% and 32% at 10 years; 5 and 10-year freedom from local recurrence were 81% and 52% respectively. Nerve involvement was found in 17/48 parotid gland adenoid cystic carcinomas. The Cox model including all patients, showed that surgery (P < 0.001), surgical margins (P = 0.015), nerve involvement (P = 0.0079), length of radiotherapy (P = 0.018), and tumour location (P = 0.041) were associated with disease free survival. Conclusion. - In this large series of adenoid cystic carcinoma of head and neck with a majority of T3-T4 tumours, 10-year survivals were achieved for 50% of patients. Radiotherapy did not impact survival. (authors)

  6. [Experience in the use of present day immunomodulators for prophylaxis of exacerbations of chronic adenoiditis and development of pharyngeal tonsil hypertrophy in poor health children].

    Science.gov (United States)

    Vavilova, V P

    2003-01-01

    Children having frequent acute respiratory infections and chronic adenoiditis were given immunomodulators (ridostin, IRS-19, polyoxidonium). As a result of such prophylaxis, respiratory infections and exacerbations of chronic adenoiditis occurred in poor-health children 2-2.5 times less frequently. Their local immunity and nonspecific resistance improved. Thus, modern immunomodulators can be used in poor-health children with chronic adenoiditis to prevent acute respiratory viral infection and development of pharyngeal tonsil hypertrophy as well as to treat them. PMID:12847808

  7. Primary adenoid cystic carcinoma of the breast: case report and review of the literature

    OpenAIRE

    Muslimani, Alaa A.; Ahluwalia, Manmeet S.; Clark, Christopher T.; Daw, Hamed A.

    2006-01-01

    Adenoid cystic carcinoma (ACC) of the breast is a rare neoplasm accounting for 0.1% of all breast carcinomas, and presenting most commonly as a painful breast mass. In contrast to the aggressive nature of ACC at other sites, ACC of the breast has a favorable prognosis, lymph node involvement or distant metastases seldom occur. Treatment is basically of simple mastectomy. Chemotherapy, radiation and hormonal treatment have been infrequently used and evaluated. We report a case of ACC of the br...

  8. Sinonasal Tract and Nasopharyngeal Adenoid Cystic Carcinoma: A Clinicopathologic and Immunophenotypic Study of 86 Cases

    OpenAIRE

    Thompson, Lester D. R.; Penner, Carla; Ho, Ngoc J.; Foss, Robert D.; Miettinen, Markku; Wieneke, Jacqueline A.; Moskaluk, Christopher A.; Stelow, Edward B.

    2013-01-01

    Primary sinonasal tract and nasopharyngeal adenoid cystic carcinomas (STACC) are uncommon tumors that are frequently misclassified, resulting in inappropriate clinical management. Eighty-six cases of STACC included 45 females and 41 males, aged 12–91 years (mean 54.4 years). Patients presented most frequently with obstructive symptoms (n = 54), followed by epistaxis (n = 23), auditory symptoms (n = 12), nerve symptoms (n = 11), nasal discharge (n = 11), and/or visual symptoms (...

  9. Laryngeal adenoid cystic carcinoma: case report / Carcinoma adenóide cístico de laringe: relato de caso

    Scientific Electronic Library Online (English)

    André, Del Negro; Edson, Ichihara; Alfio José, Tincani; Albina, Altemani; Antônio Santos, Martins.

    2007-09-01

    Full Text Available SciELO Brazil | Language: English Abstract in portuguese CONTEXTO: Carcinoma adenóide cístico (CAC) é um tumor maligno que ocorre tanto nas glândulas salivares maiores quanto nas menores. Localização laríngea é rara devido à paucidade de glândulas salivares acessórias nesta região. O carcinoma adenóide cístico representa menos de 1% das lesões malignas da [...] laringe e apenas 120 casos foram relatados na literatura. O CAC tem freqüência discretamente superior no sexo feminino e seu pico de incidência ocorre entre a quinta e sexta décadas de vida. Neste artigo, descrevemos um caso de CAC laríngeo e discutimos suas características clínicas e seu tratamento. RELATO DE CASO: Relatamos o caso de CAC numa paciente de 55 anos que apresentava disfonia e dispnéia. Características diagnósticas e avaliação terapêutica são descritas e a conduta clínica definida. Evolução clínica, estratégia terapêutica e procedimento cirúrgico são discutidos, bem como o tratamento adjuvante com radioterapia. O tumor, apesar de radiossensível, não é radiocurável. Abstract in english CONTEXT: Adenoid cystic carcinomas are malignant tumors that occur in both the major and the minor salivary glands. A laryngeal location is rare because of the paucity of accessory salivary glands in this area. Adenoid cystic carcinomas account for less than 1% of all malignant tumors in the larynx, [...] and only about 120 cases have been reported in the literature. These tumors have a slight female predisposition, and their peak incidence is in the fifth and sixth decades of life. In this article, we describe a case of laryngeal adenoid cystic carcinoma and discuss its clinical characteristics and treatment. CASE REPORT: We report on a case of laryngeal adenoid cystic carcinoma in a 55 year-old female patient who presented with dyspnea and hoarseness. Features of the diagnostic and therapeutic evaluation are described and the clinical management of such cases is outlined. The clinical course, definitive treatment strategy and surgical procedure, and also adjuvant treatment with irradiation are discussed. Although the tumor is radiosensitive, it is not radiocurable.

  10. Radiotherapy after surgery for advanced adenoid cystic carcinoma of paranasal sinus

    OpenAIRE

    Ruo Redda, Maria Grazia; Ragona, Riccardo; Succo, Giovanni; Guarneri, Alessia Silvia

    2005-01-01

    Paranasal–sinus carcinoma and nasal-cavity carcinoma are fairly rare, representing about 3% of aerodigestive malignant disease. Locally advanced lesions are usually managed best by resection and postoperative radiotherapy. In January, 2001, a 55-year-old man with stage T4N0M0 adenoid cystic carcinoma of the nasal cavity and left maxillary sinus involving cavernous sinus, left orbital floor, ethmoid sinus, and the fifth cranial nerve received resection, postoperative interstitial high-dose-r...

  11. Expressions of ABCG2, CD133, and Podoplanin in Salivary Adenoid Cystic Carcinoma

    OpenAIRE

    Wuwei Li; Ryo Tamamura; Bo Wang; Qigui Liu; Han Liu; Tingjiao Liu; Naoki Katase; Jing Xiao; Hitoshi Nagatsuka

    2014-01-01

    Adenoid cystic carcinoma (ACC) is one of the most common salivary gland malignant tumors with a high risk of recurrence and metastasis. Current studies on cancer stem cells (CSCs) have verified that CSCs are the driving force behind tumor initiation and progression, suggesting that new cancer therapies may be established by effectively targeting and killing the CSCs. The primary goal of this study is to investigate the expression patterns of ABCG2, CD133, and podoplanin in ACC of minor saliva...

  12. Values of mean platelet volume in patients with chronic tonsillitis and adenoid hypertrophy

    OpenAIRE

    Cengiz, Cevik; Erhan, Yengil; Murat, Tutanc; Ercan, Akbay; Ibrahim, Silfeler; Ihsan, Gulmez; Ertap, Akoglu

    2013-01-01

    Objectives: Chronic tonsillitis (CT)-adenoid hypertrophy (AH) is the most common cause of obstructive sleep apnea (OSA), which is one of the most common reasons of nocturnal hypoxia in children. However, there is limited information about the relationship between childhood OSA and atherosclerosis or cardiac diseases. In the present study, we evaluated the relationship between mean platelet volume (MPV) and CT-AH which is the most frequent cause leading OSA in children.

  13. Hypertrophic adenoid is a major infection site of human bocavirus 1.

    Science.gov (United States)

    Proenca-Modena, J L; Paula, F E; Buzatto, G P; Carenzi, L R; Saturno, T H; Prates, M C; Silva, M L; Delcaro, L S; Valera, F C P; Tamashiro, E; Anselmo-Lima, W T; Arruda, E

    2014-08-01

    Human bocavirus 1 (HBoV1) is associated with respiratory infections worldwide, mainly in children. Similar to other parvoviruses, it is believed that HBoV1 can persist for long periods of time in humans, probably through maintaining concatemers of the virus single-stranded DNA genome in the nuclei of infected cells. Recently, HBoV-1 was detected in high rates in adenoid and palatine tonsils samples from patients with chronic adenotonsillar diseases, but nothing is known about the virus replication levels in those tissues. A 3-year prospective hospital-based study was conducted to detect and quantify HBoV1 DNA and mRNAs in samples of the adenoids (AD), palatine tonsils (PT), nasopharyngeal secretions (NPS), and peripheral blood (PB) from patients undergoing tonsillectomy for tonsillar hypertrophy or recurrent tonsillitis. HBoV1 was detected in 25.3% of the AD samples, while the rates of detection in the PT, NPS, and PB samples were 7.2%, 10.5%, and 1.7%, respectively. The viral loads were higher in AD samples, and 27.3% of the patients with HBoV had mRNA detectable in this tissue. High viral loads and detectable mRNA in the AD were associated with HBoV1 detection in the other sample sites. The adenoids are an important site of HBoV1 replication and persistence in children with tonsillar hypertrophy. The adenoids contain high HBoV1 loads and are frequently positive for HBoV mRNA, and this is associated with the detection of HBoV1 in secretions. PMID:24920770

  14. Searching the H. pylori; serology & PCR in children with adenoid hypertrophy and rhino sinusitis: a cross sectional study, Tehran, Iran

    Science.gov (United States)

    Farhadi, Mohammad; Tabatabaei, Azardokht

    2013-01-01

    Objective Searching the H. pylori -DNAs in adenoid and IgA, IgG antibodies in serum of children. Methods A cross- sectional study had done upon 53 children (Mean age 8 ±1.9 years) with adenoid surgery in ENT and Pediatric Department of Rasul Akram Hospital (2008-2010). Of 53 cases with adenoid surgery, 40 cases had rhino sinusitis (in sinus CT scan). The resected adenoid tissues (n=40) centrifuged and homogenized and its DNAs extracted and searched for H. pylori- DNAs by qualitative PCR. Serum H. pylori antibodies (IgG &IgA ELISA) calculated quantitatively. Chi square values (p < 0.05) calculated for all categorical variables. The agreement between serologic test and PCR was assessed by the calculation of kappa statistic. Results Positive PCR for H. pylori detected in 15%of cases; regardless of sex and age of cases. Positive IgA: 17.5% (7/40) and IgG: 20% (8/40) respectively. All cases with positive H. pylori- IgG were female; p=0.003 and meaningful differences in mean age of cases observed for positive IgA (p=0.001) and IgG (p=0.01). Poor agreement observed between positive PCR and serum IgG&IgA (Fisher's Exact test=0.3; 0.5). Conclusion Positive PCR in adenoid tissue (15%) was very close to positive serum IgA (15%) but without any agreement for each case. The H. pylori infection may have a relative role at least in 15% of children with adenoid surgery. Chronic sinusitis and ear infection might be added to infected adenoid tissue as a reservoir for bacteria. The search by specific culture may elucidate better the role of H. pylori infections in both gastric and adenoid tissues. The decision for use of antibiotics to eradicate the H. pylori infection in recurrent or chronic adenotonsillar infections (with rhinosinusitis) before adenoid surgery needs Randomized Control Trial (RCT) studies. Drug of choice for eradication of H. pylori dependent to antibiotic sensitivity test in each country. PMID:23741169

  15. Adenoid cystic carcinoma intermingled with ductal carcinoma of the breast: a case report and review of the literature

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    Petrou Athanasios

    2011-09-01

    Full Text Available Abstract Introduction Adenoid cystic cancer of the breast is a rare condition, and even rarer are the cases where it is histologically mixed with other variants of cancer within a single lesion. In this report, one of the few cases of mixed adenoid cystic breast cancer intermingled with the infiltrating ductal variant is presented. A subsequent review of the relevant literature presents the existing experience in treating mixed breast cancers with adenoid cystic components with regard to diagnosis, treatment, and prognosis. Case presentation We describe a case of mixed adenoid cystic cancer of the breast with infiltrating ductal carcinoma in a 67-year-old Caucasian woman who underwent mastectomy with sentinel node biopsy. Conclusion Surgery remains the cornerstone of treatment of these patients, and radiotherapy is administered when breast-conserving treatment is undertaken or a large tumor with affected lymph nodes is present. Hormonal treatment does not have a role, as estrogen receptors are always absent from both tumor components. Chemotherapy is nearly always administered on the basis of estrogen receptor and progesterone negativity and the more aggressive potential of the non-adenoid cystic component. The de-differentiation of an indolent type of cancer to a more aggressive one may affect the prognosis.

  16. Searching Mycoplasma pneumonia by serology & PCR in children with adenoid hypertrophy and rhinosinusitis: A case control study, Tehran, Iran

    Science.gov (United States)

    Noorbakhsh, Samileh; Farhadi, Mohammad; Tabatabaei, Azardokht; Darestani, Sahar Ghavidel; Nia, Shima Javad

    2013-01-01

    Background and objectives Chronic infection in childhood is a leading cause of adeno-tonsillectomy. The aim of this study was to determine the role of M. pneumoniae in children with rhino sinusitis and adenoid hypertrophy. Method and Material This case - control study was carried out in the pediatric and ENT wards of Hazrat Rasul Hospital, Tehran, Iran (2007-2009). In this trial, we investigated 40 cases with adenoid surgery and 32 controls.We looked for M. pneumoniae -DNA (PCR) in adenoid tissues resected from cases and 31 nasopharyngeal swabs in controls and IgM & IgG antibodies (ELISA) were compared between the 2 groups, P < 0.05 was considered to show a significant value. Results Positive PCR results were observed in 35% of cases and none of controls, positive-IgG was seen in 20% of cases and 6.4% of controls (P = 0.71) which was higher in older cases (6 vs. 4 years, p < 0.05). Positive –IgM was seen in 10% of cases vs. 9.7% of controls, (P= 0.74); without any difference for age (6.2/ 5.3 years, p = 0.1). A positive PCR result was not related to positive IgG (p = 0.014), but to a positive IgM (p= 0.1). Conclusion M. pneumoniae infection was found serologically (IgM & IgG) in10% and 20% of cases, respectively. These numbers along with positive PCR in adenoid tissue of cases (30%) indicates the prominent role for M. pneumoniae in adenoid hypertrophy. We concluded that children in Iran will have been infected with M. pneumoniae and would have obtained immunity between the ages of 6 and 8. Adenoid tissue might act as a reservoir for M. pneumoniae and cause rhino sinusitis concomitant with adenoid hypertrophy in infected children. Theoretically, suitable M. pneumoniae eradicating antibiotics before adenoid surgery (with rhino sinusitis or chronic ear infection) might be helpful treatment, but it needs future RCT studies to be proven. PMID:23466609

  17. Two cases of severe tracheal stenosis due to advanced adenoid cystic carcinoma of the trachea

    International Nuclear Information System (INIS)

    Two cases of severe tracheal stenosis due to advanced nonresectable adenoid cystic carcinoma of the trachea were reported. Case 1 was a 38-year-old male who underwent emergency 60Co irradiation following endoscopic YAG laser irradiation. This approach was quite effective. Proton irradiation was effective against tumor recurrence. Case 2 was a 28-year-old female in whom emergency treatment for tracheal obstruction due to edema after laser therapy necessitated transient tracheal intubation. The tracheal stenosis due to recurrent tumor after 60Co irradiation was improved by insertion of an intraluminal permanent stent. (author)

  18. Treatment of adenoid cystic carcinoma of the salivary gland, a three-field technique.

    Science.gov (United States)

    Hummel, S M; Buchholz, T A; Laramore, G E

    1990-01-01

    Clinical trials have demonstrated that fast neutron radiotherapy is the treatment of choice for advanced inoperable salivary gland tumors. A three-field technique utilizing a medically dedicated cyclotron to produce fast neutrons is described for the treatment of adenoid cystic carcinoma of the parotid. This three-field technique utilizes the cyclotron's multi-leaf collimator system to treat large asymmetric fields, which spare normal tissues otherwise treated with conventional wedged pair techniques. Field geometry, field weightings, and beam normalization will be discussed in relation to this three-dimensional treatment volume. PMID:2171547

  19. Aggressive Adenoid Cystic Carcinoma With Asymptomatic Spinal Cord Compression Revealed By A “Curtain Sign”

    Directory of Open Access Journals (Sweden)

    Juliette Thariat

    2008-08-01

    Full Text Available

    The author presents a case with an unusually aggressive evolution of an adenoid cystic carcinoma of the head and neck. The patient presented with sciatica one year after initial diagnosis. She was otherwise asymptomatic. Complete work-up for bone involvement, included bone scan and MRI. The patient had asymptomatic thoracic (T5 vertebral metastasis revealed by a typical curtain sign on MRI. She benefited from radiotherapy and did not develop respiratory distress, paraplegia or pain but died of other metastases.

  20. Cultivo primario de células ciliadas de adenoides humanos: Un modelo experimental para evaluar la actividad ciliar in vitro Primary culture of human adenoid ciliated cells: An experimental model to evaluate ciliar activity in vitro

    Directory of Open Access Journals (Sweden)

    Claudia González

    2007-08-01

    Full Text Available Introducción: El clearance mucociliar normal es el mecanismo de defensa básico de las vías respiratorias. Sin embargo, los mecanismos de control ciliar aún se desconocen. Con el fin de entenderlo mejor, se han desarrollado diferentes técnicas de cultivo de células ciliadas. Objetivos: Desarrollar un modelo experimental a partir de cultivos primarios de tejido adenoideo y cornete medio. Caracterizarla respuesta a adenosin trifosfato (ATP, agonista conocido de la frecuencia de batido ciliar (FBC. Material y método: Cultivos primarios a partir de explantes de epitelio adenoideo y cornete medio humano. Medición de FBC, con técnica de microfotodensitometría, en condición basal y en respuesta a ATP a diferentes concentraciones. Resultados: La FBC basal (promedio (X ±desv estándar (DE para los cultivos de cornete medio fue 11,9 ±1,5 Hz y para tejido adenoideo fue 10,9 ±1,9 (p >0,05. Se observó un aumento en la FBC en respuesta a ATP, dosis dependiente. No hubo diferencia significativa en la FBC basal ni en la respuesta a ATP entre cultivos de cornete medio y adenoides. Conclusión: El cultivo primario de células ciliadas nasales a partir de explantes de adenoides, es un modelo experimental reproducible, en el que es posible observar actividad ciliary una respuesta funcional concordante con lo descrito en la literaturaIntroduction. Mucociliary clearance constitutes the main defense mechanism of the airway, but the mechanisms of ciliary control are still unknown. With the aim of a better understanding of this process, many ciliated cells culture techniques have been developed. Aims. 1. To develop an experimental model based on primary cultures from adenoid and middle turbinate tissue. 2. To characterize in this model the response to ATP, a known agonist of ciliary beat frequency (CBF. Material and Method. Primary cultures derived from human adenoid tissue and middle turbinate epithelial explants were obtained. CFB was measured by microphotodensitometry, both in basal conditions and in response to ATP at different concentrations. Results. Basal CFB (average (X +- standard deviation (SD for middle turbinate cultures was 11.9 +-1.5 Hz, and for adenoid tissue was 10.9 +-1.9 Hz (p< 0.05. A CBF increase was observed in response to ATP, in a dose-dependent manner. No significant difference in basal CFB or in response to ATP was found between middle turbinate and adenoid cultures. Conclusion. Primary culture of nasal ciliated cells derived from adenoid explants is a reproducible experimental model, in which it is possible to observe both ciliary activity and a functional response in accordance to what has been reported in the literature

  1. Clinicopathological study of 54 cases of adenoid cystic carcinoma in the head and neck

    Energy Technology Data Exchange (ETDEWEB)

    Umeno, Hirohito; Miyajima, Yoshimi; Mori, Kazunori; Nakashima, Tadashi [Kurume Univ., Fukuoka (Japan). School of Medicine

    1997-12-01

    A retrospective analysis was performed on 54 patients with adenoid cystic carcinoma in the head and neck, treated from January 1971 to July l997 in the Kurume University Hospital. The patients consisted of 35 females and 19 males, with a mean age of 59 years. The site of the lesion was the oral cavity in 13, nasal cavity in 11, submandibular gland in 8, parotid gland in 5, paranasal sinus in 3, nasopharynx in 3, oropharynx in 3, external auditory canal in 3, orbita in 2, lip in 1, lacrimal gland in 1 and trachea in 1. The over all 5-year, 10-year and 15-year survival rates as determined by the Kaplan-Meier method were 72%, 53%, and 46%, respectively. There was no relationship between survival rate and the site of the original lesion. According to the histologic criteria reported by Szanto et al., when more than 30% of the neoplasma showed a solid pattern, its treatment outcome appeared poor. In this study, the same tendency was seen. Fifteen patients died of the tumor. Ten died of distant metastasis and 5 died of local recurrence invading the cranium. No patient died of neck metastasis. Adenoid cystic carcinoma was thought to be radioresistant, but recently some authors have reported this tumor as radiosensitive. This study also showed that postoperative radiotherapy was effective, producing an increase in the survival rate. (author)

  2. Immunohistochemical expression of progesterone receptors in adenoid cystic carcinoma and pleomorphic adenoma of salivary glands

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    Eslami M

    2006-06-01

    Full Text Available Background and Aim: The hormone receptor status in breast cancer has been pivotal in determining the likelihood of response to hormonal manipulation. Tumors which are both estrogen and progesterone receptor positive are much more likely to respond to anti-hormone therapy than negative tumors. There is well-established similarity between breast tissue and salivary glands. The aim of this study was to evaluate the progesterone receptor expression in pleomorphic adenoma and adenoid cystic carcinoma of salivary glands. Materials and Methods: In this descriptive study, immunohistochemical staining with progesterone antibody was performed on 14 pleomorphic adenoma (PA and 15 adenoid cystic carcinoma (ACC paraffin blocks. The percentage of positive cells was determined using an eye piece graticule. Immunoreactivity was categorized as either positive (reactivity more than 5% or negative (reactivity less than 5%. In addition the existence of progesterone receptor in tumor cells, stromal cells (fibroblasts, inflammatory cells and salivary glands around tumors was evaluated. Data were analyzed with T and Mann Whitney U tests with p<0.05 as the limit of significance. Results: Immunohistochemical staining for progesterone receptor was negative in 15 ACC and 13 PA. Only one case of PA showed immunoreactivity for progesterone receptor. Also, 12 normal salivary glands around tumor were positive. Inflammatory cells, endothelial cells and fibroblasts did not show immunoreactivity in most cases. Conclusion: The results indicate the lack of progesterone receptor expression in ACC and PA of salivary glands.

  3. Reactive Oxygen Species and Autophagy Associated Apoptosis and Limitation of Clonogenic Survival Induced by Zoledronic Acid in Salivary Adenoid Cystic Carcinoma Cell Line SACC-83

    OpenAIRE

    Ge, Xi-yuan; Yang, Lin-qian; Jiang, Yang; Yang, Wen-wen; Fu, Jia; Li, Sheng-lin

    2014-01-01

    Salivary adenoid cystic carcinoma is an epithelial tumor in the head and neck region. Despite its slow growth, patients with salivary adenoid cystic carcinoma exhibit poor long term survival because of a high rate of distant metastasis. Lung and bone are common distant metastasis sites. Zoledronic acid, a third generation bisphosphonate, has been used for tumor-induced osteolysis due to bone metastasis and has direct antitumor activity in several human neoplasms. Here, we observed that zoledr...

  4. Adenoid cystic carcinoma in the maxillary gingiva: a case report and immunohistochemical study

    Directory of Open Access Journals (Sweden)

    Chi Zhao

    2013-03-01

    Full Text Available Gingival adenoid cystic carcinoma (ACC is a rare malignancy. We describe the diagnosis and treatment of a 43 year-old woman who presented with a persistent oral ulcer for approximately 1 year, and subsequent pain in the left posterior maxillary region. Clinical examination revealed an ulcer in the left upper molar gingiva, with swelling in the region from the second premolar to the third molar. X-ray images demonstrated the involvement of the maxillary alveolar bone. The histopathological and immunohistochemical features were diagnostic of ACC. ACC is often presented as a gingival lesion; thus, it may easily be neglected by patients. The identification of this tumor using specific pathological analyses prevents misdiagnosis and enables clinicians to determine the appropriate treatment. In this case, no recurrence or distant metastasis was observed after 2 years of follow-up.

  5. Bilateral Testicular Metastases of Adenoid Cystic Variant of Carcinoma of Prostate

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    Anita AM,

    2014-07-01

    Full Text Available Prostate cancer is the second most frequently diagnosed cancer in men (13.6% and the fifth most common cancer globally. Common sites of prostate carcinoma metastasis other than lymph nodes, include bones, lungs, urinary bladder, liver and adrenal glands. Rarely, a testicular mass, whether painful or painless, represents a metastasis. Metastasis in testes accounts for 0.06-2.5%. Bilateral testicular metastasis is less common and occurs in about 15% of cases. We report a case of prostatic adenocarcinoma in a 65 year male with metastasis to both testes identified upon histopathological examination of therapeutic orchidectomy specimen. Unusual adenoid cystic pattern seen in the metastatic deposits is highlighted. Bilateral metastasis is extremely rare and few are reported in literature

  6. A primary cutaneous adenoid-cystic carcinoma in a young woman

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    Armando Bartolazzi

    2011-03-01

    Full Text Available Primary cutaneous adenoid cystic carcinoma (PCACC is a rare slow-growing neoplasm of disputed histogenesis characterized by a cribriform pattern at histology and local aggressive behaviour. Up to date about 60 cases of PCACC have been reported in the literature. This tumour is most common in the scalp, affects middle-aged and older individuals (mean age 59 and has predilection for women. We describe an unexpected case of PCACC in a 32-years-old woman referred to our clinic for a subcutaneous nodule in the scalp showing a slow growth and indolent course. The differential diagnosis and the clinical management of this PCACC patient, successfully treated with a wide local excision, are presented and discussed.

  7. Evaluation of a German version of the tonsil and adenoid health status instrument.

    Science.gov (United States)

    Steinbichler, Teresa; Bender, Birte; Blassnigg, Elisabeth; Riechelmann, Herbert

    2014-10-31

    BackgroundTo create and validate a German version of the Tonsil and Adenoid Health Status Instrument (TAHSI) for evaluation of tonsillectomy outcome in adult patients with chronic or recurrent tonsillitis.Subjects and methods46 healthy volunteers were assessed twice in a 6 week interval with the TAHSI questionnaire. Their results were compared with 45 patients suffering from chronic tonsillitis before tonsillectomy and 6 months following surgery. For internal consistency, Cronbach¿s alpha was calculated; to identify normal score values, the optimum cutoff between healthy and diseased individuals was identified with receiver operating characteristic analysis; and responsiveness was assessed using Guyatt¿s Responsiveness Index (GRI).ResultsCronbach¿s alpha for all questions was 0.92. Test- retest intraclass correlation coefficient was 0.89 (95% confidence interval 0.80-0.94 p¿tonsillitis. PMID:25367415

  8. Treatment of Locally Advanced Adenoid Cystic Carcinoma of the Trachea With Neutron Radiotherapy

    International Nuclear Information System (INIS)

    Purpose: To examine the efficacy of fast neutron radiotherapy in the treatment of locally advanced adenoid cystic carcinoma (ACC) of the trachea and to compare outcomes with and without high-dose-rate (HDR) endobronchial brachytherapy boost. Methods and Materials: Between 1989 and 2005, a total of 20 patients with ACC of the trachea were treated with fast neutron radiotherapy at University of Washington. Of these 20 patients, 19 were treated with curative intent. Neutron doses ranged from 10.7 to 19.95 Gy (median, 19.2 Gy). Six of these patients received an endobronchial brachytherapy boost using an HDR 192Ir source (3.5 Gy x 2 fractions). Median duration of follow-up was 46 months (range, 10-121 months). Results: The 5-year actuarial overall survival rate and median overall survival for the entire cohort were 89.4%, and 97 months, respectively. Overall survival was not statistically different among those patients receiving an endobronchial boost compared with those receiving neutron radiotherapy alone (100% vs. 68%, p = 0.36). The 5-year actuarial locoregional control rate for the entire cohort was 54.1%. The locoregional control rate was not statistically different among patients who received an endobronchial boost compared with those who received neutron radiotherapy alone (40% vs. 58%, p 0.94). There were no cases of Grade ?3 acute toxicity. There were 2 cases of Grade 3/4 chronic toxicity. Conclusions: Fast neutron radiotherapy is an effective treatmtron radiotherapy is an effective treatment for locally advanced adenoid cystic carcinoma of the trachea, with acceptable treatment-related toxicity

  9. Outcomes and Prognostic Variables in Adenoid Cystic Carcinoma of the Head and Neck: A Recent Experience

    International Nuclear Information System (INIS)

    Purpose: To analyze the recent experience of patients with adenoid cystic carcinoma treated with radiation therapy at Memorial Sloan-Kettering Cancer Center. Methods and Materials: From 1990 to 2004, a total of 59 patients with a diagnosis of primary adenoid cystic carcinoma of the head and neck received radiation therapy at our institution. The subsite distribution was oral cavity, 28% (n = 17); paranasal sinuses, 22% (n = 13); parotid, 14% (n = 8); submandibular, 14% (n = 8); oropharynx, 10% (n = 6); sublingual, 3% (n = 2); nasopharynx, 3% (n = 2); and other, 5% (n = 3). T Stage distribution was T1, 34% (n = 20); T2, 19% (n = 11); T3, 14% (n = 8); and T4, 34% (n = 20). Twenty-nine percent of patients (n = 17) were treated with intensity-modulated radiation therapy; 25% (n =15), with three-dimensional conformal therapy, and the remainder, with conventional techniques. Ninety percent (n = 53) of patients received treatment including the base of skull. Results: Median follow-up for surviving patients was 5.9 years. Five-year and 10-year rates of local control and distant metastases-free survival were 91%/81% and 81%/49%, respectively. Five-year and 10-year rates of disease-free and overall survival were 76%/40% and 87%/65%, respectively. On univariate analysis, stage T4 (p = 0.004) and gross/clinical nerve involvement (p = 0.002) were associated with decreased progression free survival, whereas stage T4 and lymph node involvement were associated with decreased overall nt were associated with decreased overall survival (p = 0.046 and p < 0.001, respectively). Conclusions: Radiation therapy in combination with surgery produces excellent rates of local control, although distant metastases account for a high proportion of failures. Routine treatment to the base of skull reduces the significance of histologic perineural invasion, but major nerve involvement remains an adverse prognostic factor

  10. RadioImmunotherapy for adenoid cystic carcinoma: a single-institution series of combined treatment with cetuximab

    OpenAIRE

    Weichert Wilko; Krauss Jürgen; Jensen Alexandra D; Debus Jürgen; Münter Marc W

    2010-01-01

    Abstract Background Local control in adjuvant/definitive RT of adenoid cystic carcinoma (ACC) is largely dose-dependent. However, some clinical situations do not allow application of tumouricidal doses (i.e. re-irradiation) hence radiation sensitization by exploitation of high endothelial growth factor receptor (EGFR)-expression in ACC seems beneficial. This is a single-institution experience of combined radioimmunotherapy (RIT) with the EGFR-inhibitor cetuximab. Methods Between 2006 and 2010...

  11. Expression of ERBB3 binding protein 1 (EBP1 in salivary adenoid cystic carcinoma and its clinicopathological relevance

    Directory of Open Access Journals (Sweden)

    Sun Jian

    2012-10-01

    Full Text Available Abstract Background ERBB3 binding protein 1 (EBP1 gene transfer into human salivary adenoid cystic carcinoma cells has been shown to significantly inhibit cell proliferation and reduce tumor metastasis in mouse models. In the current study, to evaluate if EBP1 is a novel biomarker capable of identifying patients at higher risk of disease progression and recurrence, we examined the EBP1 expression profile in adenoid cystic carcinoma (ACC patients and analyzed its clinicopathological relevance. To understand the underlying anti-metastatic mechanism, we investigated if EBP1 regulates invasion-related molecules. Methods We performed immunohistochemical analysis on 132 primary adenoid cystic carcinoma and adjacent non-cancerous tissues using commercial EBP1, MMP9, E-cadherin and ICAM-1 antibodies. Results were correlated to clinicopathological parameters, long-term survival and invasion-related molecules by statistical analysis. Cell motility and invasiveness of vector or wild-type EBP1-transfected ACC-M cell lines were evaluated using wound healing and Boyden chamber assays. MMP9, E-cadherin and ICAM-1 proteins in these cell lines were detected using western blot assay. Results The expression of EBP1 was significantly higher in non-cancerous adjacent tissues compared with corresponding cancer tissues. The intensity and percentage of cells that reacted with EBP1 antibodies were significantly higher in cases with tubular pattern than those with solid pattern (PPPPPP=0.0002. Conclusions EBP1 expression is reduced in adenoid cystic carcinoma, indicating unfavorable prognosis of ACC patients. Its regulation of MMP9 and E-cadherin protein levels suggests a critical therapeutic potential.

  12. Ectopic release of GHRH and ACTH from an adenoid cystic carcinoma resulting in acromegaly and complicated by pituitary infarction.

    OpenAIRE

    Southgate, H. J.; Archbold, G. P.; El-sayed, M. E.; Wright, J.; Marks, V.

    1988-01-01

    A 23 year old man presented with a tumour mass in the lung. Subsequent investigation showed ectopic secretion of adrenocorticotrophic hormone (ACTH) and growth hormone releasing hormone (GHRH) from an adenoid cystic carcinoma. The patient progressed to show the clinical effects of long term exposure to high blood levels of both growth hormone and cortisol. The case was complicated by pituitary infarction. The very high blood levels of ACTH, growth hormone (GH) and GHRH proved resistant to tre...

  13. The effect of proteoglycans inhibited by RNA interference on metastatic characters of human salivary adenoid cystic carcinoma

    OpenAIRE

    Li Hexiang; Wang Xu; Dong Fusheng; Wang Jie; Shi Hong; Hou Yali

    2009-01-01

    Abstract Background Salivary adenoid cystic carcinoma (SACC) is one of the most common malignancies of salivary gland. Recurrence or/and early metastasis is its biological properties. In SACC, neoplastic myoepithelial cells secrete proteoglycans unconventionally full of the cribriform or tubular and glandular structures of SACC. Literatures have demonstrated that extracellular matrix provided an essential microenvironment for the biological behavior of SACC. However, there is rare study of th...

  14. Detection of Respiratory Viruses in Nasopharyngeal Swab and Adenoid Tissue from Children Submitted to Adenoidectomy: Pre- and Postoperative Analysis

    Scientific Electronic Library Online (English)

    Osvaldo Vinícius, Biill Primo; Edmir Américo, Lourenço; Saulo Duarte, Passos.

    2014-04-01

    Full Text Available SciELO Brazil | Language: English Abstract in english Introduction The presence of respiratory viruses in lymphoid tissues of the nasopharynx and oropharynx and its impact on recurrent infections and hypertrophy of these tissues are not yet fully understood. Objective To identify and determine the prevalence of major respiratory viruses in nasopha [...] ryngeal secretions and adenoid tissue pre- and postoperatively of children undergoing adenoidectomy. Methods A prospective observational study was conducted in 36 patients under 12 years of age with upper airway lymphoid hypertrophy who were undergoing adenoidectomy, in which various respiratory viruses were investigated using real-time polymerase chain reaction in adenoid tissue and nasopharyngeal secretions collected preoperatively and 30 days postoperatively. Results At least 1 viral agent was isolated in any of the samples collected in 58.3% of children and 25.9% of total samples. Respiratory viruses were identified in 33.8% of preoperative nasopharyngeal specimens and in 19.8% of postoperative secretion. Of the 21 patients with positive results for any respiratory virus, 6 (28.6%) had more than 1 virus. Considering all 36 respiratory viruses found, the main agent isolated was rhinovirus (27.8%), followed by bocavirus (22.2%). Conclusion The virus found more frequently in all samples was rhinovirus. After removal of adenoid tissue, there was a decrease in the prevalence of the virus contained in nasopharyngeal secretion 30 days after surgery.

  15. Cultivo primario de células ciliadas de adenoides humanos: Un modelo experimental para evaluar la actividad ciliar in vitro / Primary culture of human adenoid ciliated cells: An experimental model to evaluate ciliar activity in vitro

    Scientific Electronic Library Online (English)

    Claudia, González; Trinidad, Sánchez; Ximena, Fonseca; Manuel, Villalón.

    2007-08-01

    Full Text Available SciELO Chile | Language: Spanish Abstract in spanish Introducción: El clearance mucociliar normal es el mecanismo de defensa básico de las vías respiratorias. Sin embargo, los mecanismos de control ciliar aún se desconocen. Con el fin de entenderlo mejor, se han desarrollado diferentes técnicas de cultivo de células ciliadas. Objetivos: Desarrollar un [...] modelo experimental a partir de cultivos primarios de tejido adenoideo y cornete medio. Caracterizarla respuesta a adenosin trifosfato (ATP), agonista conocido de la frecuencia de batido ciliar (FBC). Material y método: Cultivos primarios a partir de explantes de epitelio adenoideo y cornete medio humano. Medición de FBC, con técnica de microfotodensitometría, en condición basal y en respuesta a ATP a diferentes concentraciones. Resultados: La FBC basal (promedio (X) ±desv estándar (DE)) para los cultivos de cornete medio fue 11,9 ±1,5 Hz y para tejido adenoideo fue 10,9 ±1,9 (p >0,05). Se observó un aumento en la FBC en respuesta a ATP, dosis dependiente. No hubo diferencia significativa en la FBC basal ni en la respuesta a ATP entre cultivos de cornete medio y adenoides. Conclusión: El cultivo primario de células ciliadas nasales a partir de explantes de adenoides, es un modelo experimental reproducible, en el que es posible observar actividad ciliary una respuesta funcional concordante con lo descrito en la literatura Abstract in english Introduction. Mucociliary clearance constitutes the main defense mechanism of the airway, but the mechanisms of ciliary control are still unknown. With the aim of a better understanding of this process, many ciliated cells culture techniques have been developed. Aims. 1. To develop an experimental m [...] odel based on primary cultures from adenoid and middle turbinate tissue. 2. To characterize in this model the response to ATP, a known agonist of ciliary beat frequency (CBF). Material and Method. Primary cultures derived from human adenoid tissue and middle turbinate epithelial explants were obtained. CFB was measured by microphotodensitometry, both in basal conditions and in response to ATP at different concentrations. Results. Basal CFB (average (X) +- standard deviation (SD)) for middle turbinate cultures was 11.9 +-1.5 Hz, and for adenoid tissue was 10.9 +-1.9 Hz (p

  16. HHV-6 is ubiquitously found using Western blot in tonsils and adenoid tissues of healthy people.

    Science.gov (United States)

    Taspinar, Mehmet; Cetin, Nilgun; Gerceker, Devran; Karasartova, Djursun; Turegun, Buse; Ozturk, Sibel; Sahin, Fikret

    2013-07-01

    Few studies have examined the prevalence and cellular proclivity of latent human herpesvirus 6 (HHV-6) in healthy populations. Difficulties in detection of HHV-6 genome in different tissues using polymerase chain reaction (PCR) and immunohistochemistry (IHC) techniques have been reported by various researchers. We examined tonsils and adenoid tissues of 54 patients who had undergone tonsillectomy or adenoidectomy without any evidence of acute infection for the presence of latent HHV-6 infection. While we were investigating the prevalence of HHV-6, we tested the efficiency of PCR, IHC and Western Blot (WB) for detection of HHV-6 in tonsil tissues. We found that 100% of tonsil tissues were positive for HHV-6 with WB, 40% of tonsils were positive with PCR and no tonsil was positive with IHC. This result correlates well with most studies claiming HHV-6 is a ubiquitous organism in various populations and tissues. Western blot may be a good choice for detecting HHV-6 in tissues. Expression of the HHV-6 gp60/110 envelope protein disclosed by WB may indicate that HHV-6 does not have true latency. To our knowledge, this is the first report to use WB to test for HHV-6 in tissues. PMID:23912866

  17. Fine-needle aspiration diagnosis of high grade adenoid cystic carcinoma metastatic to the pancreas.

    Science.gov (United States)

    David, Doina; Masineni, Sreeharsha N; Giorgadze, Tamar

    2015-02-01

    Pancreatic tumors are mostly primary tumors, with only rare metastatic tumors described in the literature. Here we report an unusual case of fine-needle aspiration (FNA) diagnosis of high grade adenoid cystic carcinoma of the parotid gland metastatic to the pancreas. The aspirate smears were moderately cellular and revealed numerous basaloid neoplastic cells. The cytomorphologic differential diagnosis included primary pancreatic tumor with small cell morphology as well as metastatic tumors. By immunocytochemistry, the tumor cells were positive for cytokeratins (AE1/AE3, CAM5.2, and CK7), and CD117 (C-KIT), and negative for CD45, WT1, synaptophysin, chromogranin, CD56, TTF-1, and CK20. The cytomorphologic features and immunoprofile in our case were consistent with high-grade carcinoma metastases from patient's known salivary gland primary. To the best of our knowledge, this case is the first reported encounter of FNA diagnosis of pancreatic metastasis with small cell morphology from a salivary gland neoplasm as primary site. PMID:24554389

  18. Adenoid Cystic Carcinoma of the Trachea: a Report of Seven Cases and Literature Review

    Directory of Open Access Journals (Sweden)

    Po-Yi Yang

    2005-05-01

    Full Text Available Background: Adenoid cystic carcinoma (ACC of the trachea is rare. The clinical manifestations,natural history, and responses to therapy differ from those of othermalignant tracheal tumors.Method: In this retrospective study, we examined pathological records of patients inthe Department of Pathology at Chang Gung Memorial Hospital from 1990through 2002. There were five male patients and two female patients withages that ranged from 21 to 55 years. For these seven patients the clinicalmanifestations and period from initial symptoms to diagnosis, treatment andoutcome are presented.Results: Hemoptysis, nonproductive cough, dyspnea, chest pain and weight loss werethe frequent early manifestations. Five patients had tumors in the lower areaof the trachea, two had tumors in the upper area of the trachea. In a patientwith the tumor in the upper area of the trachea, the tumor involved thecricoid ring, larynx, and subglottic area. In one patient with the tumor in thelower area of the trachea, the tumor invaded the right lower lobe of the lung.The longest survival time was more than 10 years.Conclusions: ACC is a rare primary tracheal malignancy. The time from first symptoms todiagnosis varied, ranging from weeks to more than 1 year. Complete surgicalresection provides the patient with the best chance of prolonged survival oreven complete remission.

  19. Adenoid Cystic Carcinoma of the Nasal Cavity and Paranasal Sinuses : A Meta-Analysis

    DEFF Research Database (Denmark)

    Amit, M.; Binenbaum, Y.

    2013-01-01

    Objectives To identify independent predictors of outcome in patients with adenoid cystic carcinoma (ACC) of the paranasal sinuses and skull base. Design Meta-analysis of the literature and data from the International ACC Study Group. Setting University-affiliated medical center. Participants The study group consisted of 520 patients, 99 of them from the international cohort. The median follow-up period was 60 months (range, 32 to 100 months). Main Outcome Measures Overall survival (OS) and disease-specific survival (DSS). Results The 5-year OS and DSS of the entire cohort were 62% and 67%, respectively. The local recurrence rate was 36.6%, and the regional recurrence rate was 7%. Distant metastasis, most commonly present in the lung, was recorded in 106 patients (29.1%). In the international cohort, positive margins and ACC of the sphenoid or ethmoidal sinuses were significant predictors of outcome (p <0.001). Perineural invasion and adjuvant treatment (radiotherapy or chemoradiation) were not associated withprognosis. Conclusion Tumor margin status and tumor site are associated with prognosis in ACC of the paranasal sinuses, whereas perineural invasion is not. Adjuvant treatment apparently has no impact on outcome.

  20. Expression and significance of notch signaling pathway in salivary adenoid cystic carcinoma.

    Science.gov (United States)

    Bell, Diana; Hanna, Ehab Y; Miele, Lucio; Roberts, Dianna; Weber, Randal S; El-Naggar, Adel K

    2014-02-01

    Notch signaling plays a role in stem cell biology, tumor formation, angiogenesis, and cell death. Targeting Notch pathway could serve as a therapeutic strategy in cancer. Little is known about the differential role of various components of the Notch pathway in salivary adenoid cystic carcinoma (AdCC). To investigate the association of the Notch pathway in AdCC carcinogenesis, we analyzed the Notch receptor (Notch-1, Notch-2, Notch-4) and Notch ligand (Jagged-1, Delta) expressions. The results showed elevated expression levels of all 5 proteins in AdCC tissue relative to normal salivary gland tissues. Jagged-1/Notch-2 coexpression was significantly associated with increased patient survival rate. The elevated expression level of these Notch receptors and ligands in AdCC points to Notch signaling as a key player in AdCC pathogenesis. Our data provide evidence for a relationship between Jagged-1/Notch-2 coexpression and better overall patient survival with AdCC. Targeting Notch signaling pathway may provide therapeutic benefits for these patients. PMID:24238845

  1. Expressions of ABCG2, CD133, and podoplanin in salivary adenoid cystic carcinoma.

    Science.gov (United States)

    Li, Wuwei; Tamamura, Ryo; Wang, Bo; Liu, Qigui; Liu, Han; Liu, Tingjiao; Katase, Naoki; Xiao, Jing; Nagatsuka, Hitoshi

    2014-01-01

    Adenoid cystic carcinoma (ACC) is one of the most common salivary gland malignant tumors with a high risk of recurrence and metastasis. Current studies on cancer stem cells (CSCs) have verified that CSCs are the driving force behind tumor initiation and progression, suggesting that new cancer therapies may be established by effectively targeting and killing the CSCs. The primary goal of this study is to investigate the expression patterns of ABCG2, CD133, and podoplanin in ACC of minor salivary glands by immunohistochemistry analysis. We found that ABCG2 was weakly expressed in normal looking salivary gland tissues. A significant upregulation of ABCG2 expression in ACC was observed with a similar expression pattern of Ki-67. CD133 was detected in apical membrane of epithelial cells and podoplanin was expressed positively in myoepithelial cells of both normal looking tissue and ACC. However, no significant difference was found of the expression pattern of CD133 and podoplanin between normal looking tissues and ACC. Our observations suggest that CSCs may exist in quiescent cells with ABCG2 positive staining, which are surrounded by cells with positive expression of ABCG2 and Ki-67 in ACC, and costaining with ABCG2 and Ki-67 may help predict the location of CSCs. PMID:24804195

  2. Notch signaling induces epithelial-mesenchymal transition to promote invasion and metastasis in adenoid cystic carcinoma

    Science.gov (United States)

    Zhao, Zhi-Li; Ma, Si-Rui; Wang, Wei-Ming; Huang, Cong-Fa; Yu, Guang-Tao; Wu, Tian-Fu; Bu, Lin-Lin; Wang, Yu-Fan; Zhao, Yi-Fang; Zhang, Wen-Feng; Sun, Zhi-Jun

    2015-01-01

    Epithelial-mesenchymal transition (EMT) is considered to have pivotal roles in the invasive and metastatic of Adenoid cystic carcinoma (AdCC) which is marked by local infiltration and distant metastasis. Notch signaling abnormity has been implicated as important molecular events in recent next generation sequencing studies of AdCC, but the detail is still unclear. This study was designed to investigate the expression of Notch signaling pathway and its relation with EMT program in AdCC. We constructed custom-made Tissue microarray (TMA) to evaluate the immunoreactivity of Notch signaling and EMT program and found that Notch signaling increase consecutively from NSG, PMA to AdCC, suggesting Notch signaling pathway may be associated with human AdCC progression. Then, we carried out Pearson correlation analysis and showed a close correlation of Notch signaling and EMT progression. When blocking Notch signaling pathway with ?-secretase inhibitor DAPT, EMT progression was decreased and migration and invasion ability were declined. Collectively, these findings suggest the vital roles of Notch signaling pathway in AdCC progression through their relationship with EMT progress. Targeting Notch signaling may provide further understanding of the mechanism of invasion and metastasis of AdCC as well as potential clinical therapeutics. PMID:25755838

  3. Results of fast neutron therapy of adenoid-cystic carcinomas of the head and neck at the neutron therapy facility Hamburg-Eppendorf

    International Nuclear Information System (INIS)

    Between 1977 and 1987, 30 patients with adenoid-cystic carcinomas of the head and neck region were treated, at the Hamburg-Eppendorf neutron therapy facility, with a 14 MeV-DT-generator. The present review deals with 15 patients treated before October 1986 e.g. with follow up longer than one year. These results, although preliminary, tend to confirm that fast neutrons is the best irradiation modality of adenoid-cystic carcinomas of the head and neck-region, especially when surgery is not possible, or cannot be radical. (orig.)

  4. Literature review on the role of radiotherapy in the treatment of nasopharyngeal cystic adenoid carcinomas about two cases

    International Nuclear Information System (INIS)

    The authors discuss the characteristics and the radiotherapy treatment procedures of cystic adenoid carcinomas, and more precisely the treatment of two of such cases of nasopharyngeal carcinomas. The first one had an incomplete resection surgery followed by curing radiotherapy: he has then been in local-regional control situation for 8 months. The second one had lung metastases, was treated chemotherapy and radiotherapy (decompressive treatment), and died six months after diagnosis. Radiotherapy is considered to be the treatment basis, whereas chemotherapy is a matter of controversy. Short communication

  5. Treatment of locally advanced adenoid cystic carcinoma of the head and neck with neutron radiotherapy

    International Nuclear Information System (INIS)

    Purpose: To examine the efficacy of fast neutron radiotherapy for the treatment of locally advanced and/or recurrent adenoid cystic carcinoma of the head and neck and to identify prognostic variables associated with local-regional control and survival. Methods and Materials: One hundred fifty-nine patients with nonmetastatic, previously unirradiated, locally advanced, and/or recurrent adenoid cystic carcinoma (ACC) of the head and neck region were treated with fast neutron radiotherapy during the years 1985-1997. One hundred fifty-one patients had either unresectable disease, or gross residual disease (GRD) after an attempted surgical extirpation. Eight patients had microscopic residual disease and were analyzed separately. Sixty-two percent of patients had tumors arising in minor salivary glands, 29% in major salivary glands, and 9% in other sites such as the lacrimal glands, tracheal-bronchial tree, etc. Fifty-five percent of patients were treated for postsurgical recurrent disease and 13% of patients had lymph node involvement at the time of treatment. The median duration of follow-up was 32 months (range 3-142 months). Actuarial curves for survival, cause-specific survival, local-regional control, and the development of distant metastases are presented for times out to 11 years. Results: The 5-year actuarial local-regional tumor control rate for the 151 patients with GRD was 57%; the 5-year actuarial overall survival rate was 72%; and the 5-year actuarial cause-spwas 72%; and the 5-year actuarial cause-specific survival rate was 77%. Variables associated with decreased local-regional control in the patients with GRD as determined by multivariate analysis included base of skull involvement (p < 0.01) and biopsy only versus an attempted surgical resection prior to treatment (p = 0.03). Patients without these negative factors had an actuarial local-regional control rate of 80% at 5 years. Patients with microscopic residual disease (n = 8) had a 5-year actuarial local-regional control rate of 100%. Base of skull involvement (p < 0.001), lymph node metastases at the time of treatment (p < 0.01), biopsy only prior to neutron radiotherapy (p = 0.03), and recurrent tumors (p = 0.04) were found to be associated with a diminished cause-specific survival as ascertained by multivariate analysis. Patients with base of skull involvement and positive lymph nodes at presentation had an increased rate of the development of distant metastases at 5 years, (p < 0.01 and p <0.001, respectively). No statistical difference in outcome was observed between major and minor salivary gland sites. Conclusions: Fast neutron radiotherapy is an effective treatment for locally advanced ACC of the head and neck region with acceptable toxicity. Further improvements in local-regional control are not likely to impact survival until more effective systemic agents are developed to prevent and/or treat distant metastatic disease

  6. Adenoid cystic carcinoma of the parotid gland: Anastamosis of the facial nerve with the great auricular nerve after radical parotidectomy

    Directory of Open Access Journals (Sweden)

    Bahadir Osman

    2008-01-01

    Full Text Available Adenoid cystic carcinoma of the parotid gland is a rare and slowly growing, but highly malignant tumor. Surgical resection of a malignant parotid tumor should include resection of the facial nerve when the nerve is involved in the tumor. Facial nerve reconstruction is required after nerve resection. A 14 year-old female presented with complaints of painless enlargement of the right parotid gland and facial asymmetry. Physical examination revealed a firm mass in the region of the parotid gland as well as right facial paralysis. Biopsy obtained from the mass showed an adenoid cystic carcinoma of the parotid gland. A radical parotidectomy with a modified radical neck dissection was carried out. Grafting material for the facial reconstruction was harvested from the great auricular nerve. The proximal main trunk and each distal branch of the facial nerve were coapted with the greater auricular nerve. The patient received radiotherapy after surgery and was seen to achieve grade IV facial function one year after surgery. Thus, the great auricular nerve is appropriate grafting material for coaptation of each distal branch of the facial nerve.

  7. Expression of p-AKT characterizes adenoid cystic carcinomas of head and neck with a higher risk for tumor relapses

    Directory of Open Access Journals (Sweden)

    Müller-Hermelink Hans-Konrad

    2009-06-01

    Full Text Available Abstract Background Adenoid cystic carcinomas are rare tumors with an indolent clinical course, but frequent local relapses. The identification of tumors with a higher relapse risk seems to be interesting. Hence we investigated parameters of glucose metabolism, which were found associated with poor prognosis in other malignancies. Methods Specimen of 29 patients were investigated immunohistochemically with antibodies against p-AKT, TKTL-1 (transketolase-like 1, M2PK (M2 pyruvate kinase, and GLUT-1. Proliferation was investigated by staining with Ki67. The tumors were located at the major or minor salivary glands. Only the typical cribriform subtype was investigated. The initial tumor stage was pT1 or pT2. Results Expression of p-AKT was significantly (P = 0.036 associated with a higher relapse risk in multivariate analysis. Low expression of M2PK was non-significantly (P = 0.065 predictive for a higher risk. TKTL-1 and GLUT-1 were expressed in the majority of cases, albeit not associated with relapse risk. Conclusion Adenoid cystic carcinomas positive for p-AKT show a higher relapse risk. However, other parameters of glucose metabolism investigated here or proliferation (Ki67 were not predictive in this entity. Our findings demonstrate a possible background for therapeutic approaches targeting the inhibition of PI3K/AKT pathway.

  8. A retrospective study of 18 cases of adenoid cystic cancer at a tertiary care centre in Delhi

    Directory of Open Access Journals (Sweden)

    Sharma K

    2010-01-01

    Full Text Available Context: Adenoid cystic carcinoma (ACC is a rare neoplasm that usually arises from the salivary, lacrimal, or other exocrine glands. It is characteristically locally infiltrative in nature and has a tendency toward local recurrence, high propensity for perineural invasion, and prolonged clinical course. Aim: To analyze the presentation and natural history of cases of adenoid cystic tumors of salivary glands in our institution; and to compare with the existing literature. Design and Setting: Retrospective study at the Department of Radiotherapy. Materials and Methods: Data on 18 patients of ACC of the salivary glands treated between 2004 and 2008 were reviewed with respect to clinical presentation, stage, and histology. Results: There were 8 cases of major salivary gland tumors (47%, of which 2 were in the submandibular and 6 were involving the parotid. Ten patients (53% had minor salivary gland involvement. Two patients had metastasis at the time of presentation. All patients underwent surgery. Radiotherapy was delivered to 16 patients and chemotherapy to 6 patients (concurrent, n = 3 and adjuvant, n = 3 and no adjuvant therapy was given to 2 patients. All patients were alive at a median follow-up of 3 years. No patient developed local or distant failure during the study duration. Conclusion: ACC has locally aggressive behavior. Radiotherapy adjuvant to surgery improves local control in locally advanced disease. Longer follow-up is mandatory in view of incidence of late metastasis.

  9. Management of Adenoid Cystic Carcinoma of the Breast: A Rare Cancer Network Study

    International Nuclear Information System (INIS)

    Background: Mammary adenoid cystic carcinoma (ACC) is a rare breast cancer. The aim of this retrospective study was to assess prognostic factors and patterns of failure, as well as the role of radiation therapy (RT), in ACC. Methods: Between January 1980 and December 2007, 61 women with breast ACC were treated at participating centers of the Rare Cancer Network. Surgery consisted of lumpectomy in 41 patients and mastectomy in 20 patients. There were 51(84%) stage pN0 and 10 stage cN0 (16%) patients. Postoperative RT was administered to 40 patients (35 after lumpectomy, 5 after mastectomy). Results: With a median follow-up of 79 months (range, 6–285), 5-year overall and disease-free survival rates were 94% (95% confidence interval [CI], 88%–100%) and 82% (95% CI, 71%–93%), respectively. The 5-year locoregional control (LRC) rate was 95% (95% CI, 89%–100%). Axillary lymph node dissection or sentinel node biopsy was performed in 84% of cases. All patients had stage pN0 disease. In univariate analysis, survival was not influenced by the type of surgery or the use of postoperative RT. The 5-year LRC rate was 100% in the mastectomy group versus 93% (95% CI, 83%–100%) in the breast-conserving surgery group, respectively (p = 0.16). For the breast-conserving surgery group, the use of RT significantly correlated with LRC (p = 0.03); the 5-year LRC rates were 95% (95% CI, 86%–100%) for the RT group versus 83% (95% CI, 54%–100%) for the group receiving no RT. No logroup receiving no RT. No local failures occurred in patients with positive margins, all of whom received postoperative RT. Conclusion: Breast-conserving surgery is the treatment of choice for patients with ACC breast cancer. Axillary lymph node dissection or sentinel node biopsy might not be recommended. Postoperative RT should be proposed in the case of breast-conserving surgery.

  10. Reliability of adenoid hypertrophy diagnosis by cephalometric radiography / Confiabilidade do diagnóstico da hipertrofia das adenóides por meio da cefalometria

    Scientific Electronic Library Online (English)

    Alexandre Jose, RETCHESKI; Nelson Padilha da, SILVA; Fernanda, LEITE; Paulo Roberto Aranha, NOUER.

    2014-09-01

    Full Text Available SciELO Brazil | Language: English Abstract in portuguese OBJETIVO: Verificar a confiabilidade do diagnóstico da hipertrofia das adenóides por meio da cefalometria. MÉTODOS: Trinta indivíduos do gênero masculino, com idades entre 12 e 15 anos, [...] respiradores bucais ou não, foram selecionados e neles realizados exames de diagnóstico de hipertrofia da adenóide por cefalometria radiológica, a partir da telerradiografia em norma lateral e exames rinoscópicos, a partir da nasofibroscopia (padrão ouro). A cefalometria utilizada foi a computadorizada e para isto se utilizou o programa CefX versão 2000 e a rinoscopia foi realizada com um nasofibroscópio flexível. Foi tomado como ponto de corte 47% e 75% de bloqueio da nasofaringe para a telerradiografia e nasofibroscopia, respectivamente. RESULTADOS: A correlação encontrada entre os dois exames foi considerada moderadamente positiva (0,5) e os testes de validade e confiabilidade registraram uma sensibilidade de 100%, especificidade de 65,5%, valor preditivo positivo de 9,1%, valor preditivo negativo de 100% e exatidão de 66,60%. CONCLUSÃO: A telerradiografia lateral foi considerada um meio prático, confortável para o paciente e relativamente eficiente na detecção da hiperplasia da adenóide e na obtenção do diagnóstico de obstrução nasofaringeana. Abstract in english OBJECTIVE: To verify the reliability of adenoid hypertrophy diagnosis by cephalometric radiography. METHOD: Thirty male subjects, aged between 12 and 15 years, either mouth-breathers, or [...] not, were selected. Diagnostic tests for adenoid hypertrophy were performed by radiological cephalometry based on lateral cephalometric radiographs and nasal endoscopy (gold standard). The CefX Cephalometric software program, version 2000 was used and the rhinoscopy was performed with a flexible endoscope. Blockage of 47% and 75% of the nasopharynx were taken as the cutoff points for cephalometric radiography and endoscopy, respectively. RESULTS: The correlation between the two examinations was considered moderately positive (0.5). Tests of validity and reliability reported a sensitivity of 100%; specificity 65.5%; positive predictive value of 9.1%; negative predictive value 100%, and exactness of 66.60%. CONCLUSION: Lateral cephalometric radiography was considered practical and comfortable for the patient; relatively efficient for detecting adenoid hypertrophy and obtaining the diagnosis of nasopharyngeal airway obstruction.

  11. Radiographic adenoid evaluation: proposal of an objective parameter / Avaliação radiográfica da tonsila faríngea: proposição de um método de medição objetivo

    Scientific Electronic Library Online (English)

    Murilo Fernando Neuppmann, Feres; Juliana Sato, Hermann; Ana Carolina, Sallum; Shirley Shizue Nagata, Pignatari.

    2014-04-01

    Full Text Available Objetivo O objetivo deste estudo foi avaliar parâmetros radiográficos atuais destinados à verificação da adenoide e obstrução nasofaríngea e apresentar um método de avaliação alternativo. Materiais e Métodos Crianças (4 a 14 anos) que apresentavam queixas de obstrução nasal e/ou respiração oral f [...] oram submetidas ao exame radiográfico de cavum faríngeo. Cento e vinte registros foram avaliados por parâmetros radiográficos quantitativos, e estes dados foram correlacionados ao exame de videonasofaringoscopia, aqui considerado como padrão ouro, em relação à porcentagem de obstrução coanal. Posteriormente, uma análise de regressão foi realizada com os mesmos parâmetros quantitativos, de modo que um modelo original fosse criado com o objetivo de predição do percentual de obstrução coanal. Resultados Os parâmetros quantitativos atuais demonstraram correlações moderadas, quando não fracas, ao percentual de obstrução. O modelo de regressão desenvolvido (110.119*A/N) demonstrou capacidade satisfatória de “prever” o real percentual de obstrução adenóidea. Conclusão Uma vez que os parâmetros radiográficos atuais apresentam limitações, o modelo original aqui apresentado deve ser considerado como um método de avaliação adenóidea alternativo, a ser utilizado quando a videonasofaringoscopia estiver indisponível. Abstract in english Objective The objective of the present study was to evaluate current radiographic parameters designed to investigate adenoid hypertrophy and nasopharyngeal obstruction, and to present an alternative radiographic assessment method. Materials and Methods In order to do so, children (4 to14 years ol [...] d) who presented with nasal obstruction or oral breathing complaints were submitted to cavum radiographic examination. One hundred and twenty records were evaluated according to quantitative radiographic parameters, and data were correlated with a gold-standard videonasopharyngoscopic study, in relation to the percentage of choanal obstruction. Subsequently, a regression analysis was performed in order to create an original model so the percentage of the choanal obstruction could be predicted. Results The quantitative parameters demonstrated moderate, if not weak correlation with the real percentage of choanal obstruction. The regression model (110.119*A/N) demonstrated a satisfactory ability to “predict” the actual percentage of choanal obstruction. Conclusion Since current adenoid quantitative radiographic parameters present limitations, the model presented by the present study might be considered as an alternative assessment method in cases where videonasopharyngoscopic evaluation is unavailable.

  12. Long-term survival of a patient with extensive intracranial infiltration of adenoid cystic carcinoma of the lacrimal gland

    International Nuclear Information System (INIS)

    Adenoid cystic carcinoma (ACC) of the lacrimal gland is a rare neoplasm associated with poor prognosis. Because of its inherent tendency toward local infiltration and perineural spread, involving a high risk of local recurrences and intracranial extension as well as the risk of regional lymph node and distant metastases development, aggressive approach with orbital exenteration, irradiation and chemotherapy has been used. However, the natural course of ACC of the lacrimal gland is not well known. We present a case of long-term survival of a 48-year-old male patient with ACC located in the lacrimal gland, who underwent non-radical resection of malignant tumor and received palliative chemotherapy with doxorubicin and cisplatin. This patient lived for almost 14 years after diagnosis. Thirteen out of teahouse years the patient lived without serious complaints, and in good performance status. (authors)

  13. Adenoid cystic carcinoma of the cardia: Report of a rare case and review of the Chinese literature.

    Science.gov (United States)

    Zhou, Yiming; Zang, Yiwen; Xiang, Jianbin; Tang, Feng; Chen, Zongyou

    2014-08-01

    Adenoid cystic carcinoma (ACC) is a relatively common head and neck tumor, however, is rare in the digestive tracts. There have been radical total gastrectomy with D2 lymphadenectomy and Roux-en-Y esophagojejunal reconstruction. Immunohistochemical analysis identified a case of primary ACC that exhibited a positive expression for cytokeratin, calponin, cluster of differentiation 117, p63 and smooth muscle actin, with typical cribriform foci. No signs of recurrence have been detected during the 30-month follow-up. Thus, a precise diagnosis of ACC is primarily based on the results of immunohistochemical analysis and radical resection is considered to be the best treatment option for ACC of the digestive tracts. The current study also reviewed 17 cases of ACC of the esophagus reported in China, with special reference to the criteria for histological diagnosis and therapeutic options. The prognosis of esophageal ACC is poor due to early metastasis, mainly relying on the resectability of the tumor. PMID:25013491

  14. Breast adenoid cystic carcinoma in a 19-year-old man: a case report and review of the literature.

    Science.gov (United States)

    Tang, Peng; Yang, Shiping; Zhong, Xiaojie; Yao, Jia; Zhang, Yu; Dong, Huaying; Li, Guanqiao

    2015-12-01

    Adenoid cystic carcinoma (ACC) of the breast is very rare in males. There have been only eight previous articles published on breast ACC in males. Here, we will report on the first case of this type of tumor in the Chinese province of Hainan. The patient was a 19-year-old male, and he underwent a radical mastectomy (RM) with axillary lymph node dissection. The histopathological examination specimen revealed that surgical margins were negative; none of the 41 axillary lymph nodes excised were positive for malignancy. The patient is alive and well 67 months after radical mastectomy. In the present study, we discuss the diagnosis and treatment options for male breast ACC based on previous English publications. PMID:25778021

  15. [The tonsils and adenoids as a site of infection and the cause of obstruction].

    Science.gov (United States)

    Battistini, A; Siepe, F; Marvasi, R

    1998-01-01

    The failure to eradicate group A beta-hemolytic streptococci from the pharynx is partly due to a low compliance, but above all, an alteration of the oropharyngeal microbiological flora: reduction of alpha-haemolytic streptococci which inhibit group A beta-hemolytic streptococci and increase of microorganisms such as Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis. These latter act indirectly destroying the beta-lactamic ring of penicillins. However, this obstacle is overcome by the use of antibiotics which do not contain beta-lactamic rings such as macrolides or associating amoxicillin with clavulanic acid or with new cephalosporins which are more resistant to beta lactamases. To restrict the diffusion of resistance to antibiotics, it is essential to limit their use diagnosing streptococcal tonsillopharyngitis more precisely, thanks to an improved use of micro-biological diagnostic tests and by a more extended use of tonsillectomy in recurrent tonsillitis (more than 6-7 in 1-2 years). Adenoiditis is closely related to the post nasal drip syndrome, to recurrent otitis media and to otitis media with effusion. All these situations could, therefore, represent an indication, although not well defined, for adenoidectomy. Nasopharyngeal obstruction due to adeno-tonsillar hypertrophy becomes critical during sleep when the hypotony of the upper airway muscles becomes additional to the anatomical obstruction. At this point the inspiratory effort required and the consequent decrease of intra airway pressure increase the pharyngeal obstruction suctioning the pharyngeal walls toward the median line. The resulting clinical picture is defined as sleep-disordered breathing (SDB) due to adenotonsillar hypertrophy (idiopathic), to be distinguished from SDB due to cranio-facial abnormalities or neuromuscular diseases. SDB includes both the more serious sleep apnea syndrome and the less severe upper airway respiratory resistance syndrome. A combination of symptoms and clinical data detectable both while awake or asleep, make the diagnosis simple. During sleep, both apnea and paradoxical inspiratory movements are highly specific while snoring is highly sensitive. To evaluate nasopharyngeal obstruction radiography and optic fibre endoscopy are both equally reliable. The gold standard test for non idiopathic SDB is the polysomnography, whereas for SDB, due to adenotonsillar hypertrophy, one is limited today to the recording during sleep of O2 saturation or of end tidal CO2. These investigations are, however, generally used up to 2 years of age, when the decision to carry out an adenoidectomy and especially a tonsillectomy is more difficult because of the greater risks which surgery involves at this age. The pharmacological therapy has a purely palliative function and is based on antibiotics, local vasoconstrictors, steroids and theophylline which acts more as an antiflogistic than as a breath stimulant. O2 therapy and nasal continuous positive airway pressure (CPAP) give better results, but are more difficult to carry out, in particular on a long term basis. Adenoidectomy especially if associated with tonsillectomy, leads to the resolution of the symptoms, but not always to a normalization of functional alterations (hypoxia and hypercapnia). For this reason, it is necessary to act on other factors which cause oedema of the nasopharyngeal mucosa contributing to the obstruction. In this area, the prevention of viral infections can be achieved by vaccination against influenza and by preventing the child from attending crowded day care centers. With regard to allergic inflammation, skin prick tests could be a first step in view of allergens avoidance measures. With regard to indoor air pollution, passive smoke must be stopped and the child kept out of the kitchen. PMID:9866845

  16. RadioImmunotherapy for adenoid cystic carcinoma: a single-institution series of combined treatment with cetuximab

    Directory of Open Access Journals (Sweden)

    Weichert Wilko

    2010-11-01

    Full Text Available Abstract Background Local control in adjuvant/definitive RT of adenoid cystic carcinoma (ACC is largely dose-dependent. However, some clinical situations do not allow application of tumouricidal doses (i.e. re-irradiation hence radiation sensitization by exploitation of high endothelial growth factor receptor (EGFR-expression in ACC seems beneficial. This is a single-institution experience of combined radioimmunotherapy (RIT with the EGFR-inhibitor cetuximab. Methods Between 2006 and 2010, 9 pts received RIT for advanced/recurrent ACC, 5/9 pts as re-irradiation. Baseline characteristics as well as treatment parameters were retrieved to evaluate efficacy and toxicity of the combination regimen were evaluated. Control rates (local/distant and overall survival were calculated using Kaplan-Meier estimation. Results Median dose was 65 Gy, pts received a median of 6 cycles cetuximab. RIT was tolerated well with only one °III mucositis/dysphagia. Overall response/remission rates were high (77,8%; 2-year estimate of local control was 80% hence reaching local control levels comparable to high-dose RT. Progression-free survival (PFS at 2 years and median overall survival were only 62,5% and 22,2 mo respectively. Conclusion While local control and treatment response in RIT seems promising, PFS and overall survival are still hampered by distant failure. The potential benefit of RIT with cetuximab warrants exploration in a prospective controlled clinical trial.

  17. A unifying gene signature for adenoid cystic cancer identifies parallel MYB-dependent and MYB-independent therapeutic targets.

    Science.gov (United States)

    Gao, Ruli; Cao, Chunxia; Zhang, Min; Lopez, Maria-Cecilia; Yan, Yuanqing; Chen, Zirong; Mitani, Yoshitsugu; Zhang, Li; Zajac-Kaye, Maria; Liu, Bin; Wu, Lizi; Renne, Rolf; Baker, Henry V; El-Naggar, Adel; Kaye, Frederic J

    2014-12-30

    MYB activation is proposed to underlie development of adenoid cystic cancer (ACC), an aggressive salivary gland tumor with no effective systemic treatments. To discover druggable targets for ACC, we performed global mRNA/miRNA analyses of 12 ACC with matched normal tissues, and compared these data with 14 mucoepidermoid carcinomas (MEC) and 11 salivary adenocarcinomas (ADC). We detected a unique ACC gene signature of 1160 mRNAs and 22 miRNAs. MYB was the top-scoring gene (18-fold induction), however we observed the same signature in ACC without detectable MYB gene rearrangements. We also found 4 ACC tumors (1 among our 12 cases and 3 from public databases) with negligible MYB expression that retained the same ACC mRNA signature including over-expression of extracellular matrix (ECM) genes. Integration of this signature with somatic mutational analyses suggests that NOTCH1 and RUNX1 participate with MYB to activate ECM elements including the VCAN/HAPLN1 complex. We observed that forced MYB-NFIB expression in human salivary gland cells alters cell morphology and cell adhesion in vitro and depletion of VCAN blocked tumor cell growth of a short-term ACC tumor culture. In summary, we identified a unique ACC signature with parallel MYB-dependent and independent biomarkers and identified VCAN/HAPLN1 complexes as a potential target. PMID:25587024

  18. Effects of 5-aza-2?deoxycytidine on RECK gene expression and tumor invasion in salivary adenoid cystic carcinoma

    Scientific Electronic Library Online (English)

    X.Q., Zhou; S.Y., Huang; D.S., Zhang; S.Z., Zhang; W.G., Li; Z.W., Chen; H.W., Wu.

    Full Text Available Reversion-inducing cysteine-rich protein with kazal motifs (RECK), a novel tumor suppressor gene that negatively regulates matrix metalloproteinases (MMPs), is expressed in various normal human tissues but downregulated in several types of human tumors. The molecular mechanism for this downregulatio [...] n and its biological significance in salivary adenoid cystic carcinoma (SACC) are unclear. In the present study, we investigated the effects of a DNA methyltransferase (DNMT) inhibitor, 5-aza-2?deoxycytidine (5-aza-dC), on the methylation status of the RECK gene and tumor invasion in SACC cell lines. Methylation-specific PCR (MSP), Western blot analysis, and quantitative real-time PCR were used to investigate the methylation status of the RECK gene and expression of RECK mRNA and protein in SACC cell lines. The invasive ability of SACC cells was examined by the Transwell migration assay. Promoter methylation was only found in the ACC-M cell line. Treatment of ACC-M cells with 5-aza-dC partially reversed the hypermethylation status of the RECK gene and significantly enhanced the expression of mRNA and protein, and 5-aza-dC significantly suppressed ACC-M cell invasive ability. Our findings showed that 5-aza-dC inhibited cancer cell invasion through the reversal of RECK gene hypermethylation, which might be a promising chemotherapy approach in SACC treatment.

  19. Prevention of surgery in children with adenoidal hypertrophy treated with intranasal flunisolide: a 12-month follow-up.

    Science.gov (United States)

    Varricchio, A; Tortoriello, G; Capasso, M; De Lucia, A; Marchisio, P; Varricchio, A M; Mansi, N; Giordano, L; Liberatore, G; Di Gioacchino, M; Ciprandi, G

    2009-01-01

    Adenoidal hypertrophy (AH) represents one of the most frequent indications for surgery in children. Recently, treatment with intranasal corticosteroids has been suggested to decrease the size of AH. The aim of the study is to evaluate the long-term effect of intranasal flunisolide on AH during a 12-month follow-up. One hundred seventy-eight children with a grade III or IV AH at baseline endoscopic examination were enrolled in this randomised and controlled study. Children were treated with intranasal flunisolide or isotonic saline solution for 8 weeks. Subsequent assessment, including history and fiberoptic endoscopy, was made at 8 weeks, and 6 and 12 months after treatment suspension. Flunisolide treatment was initially associated with significant (p<0.01) reduction of the degree of AH. However, during follow-up all but one of the non-allergic children relapsed, whereas most allergic children maintained AH size reduction (p<0.05). No clinically important adverse events were reported. In conclusion, this preliminary study demonstrates that an 8-week treatment with intranasal flunisolide is significantly associated with reduction of AH, however, the adenoidectomy avoidance was warranted only for allergic children. PMID:19589290

  20. Analysis of failure in patients with adenoid cystic carcinoma of the head and neck an international collaborative study

    DEFF Research Database (Denmark)

    Amit, Moran; Binenbaum, Yoav

    2013-01-01

    BACKGROUND Adenoid cystic carcinoma (ACC) is a locally aggressive tumor with a high prevalence of distant metastases. The current study aimed to identify independent predictors of outcome and to characterize the patterns of failure. METHODS: An international retrospective review of 489 ACC patients treated between 1985 and 2011 in 9 cancer centers worldwide. RESULTS: Five-year overall-survival (OS), disease-specific survival(DSS) and disease-free survival (DFS) were 76%, 80% and 68%, respectively. Independent predictors of OS and DSS were: age, site, N classification and presence of distant metastases(DM). N stage, age and bone invasion were associated with DFS on multivariate analysis. Age, tumor site, orbital invasion and N stage were independent predictors of DM. CONCLUSION: The clinical course of ACC is slow but persistent. Paranasal sinus origin is associated with the lowest distant metastasis rate but with the poorest outcome. These prognostic estimates should be considered when tailoring treatment for patients with ACC. Head Neck, 2013.

  1. Effects of 5-aza-2?deoxycytidine on RECK gene expression and tumor invasion in salivary adenoid cystic carcinoma

    Scientific Electronic Library Online (English)

    X.Q., Zhou; S.Y., Huang; D.S., Zhang; S.Z., Zhang; W.G., Li; Z.W., Chen; H.W., Wu.

    2015-03-01

    Full Text Available Reversion-inducing cysteine-rich protein with kazal motifs (RECK), a novel tumor suppressor gene that negatively regulates matrix metalloproteinases (MMPs), is expressed in various normal human tissues but downregulated in several types of human tumors. The molecular mechanism for this downregulatio [...] n and its biological significance in salivary adenoid cystic carcinoma (SACC) are unclear. In the present study, we investigated the effects of a DNA methyltransferase (DNMT) inhibitor, 5-aza-2?deoxycytidine (5-aza-dC), on the methylation status of the RECK gene and tumor invasion in SACC cell lines. Methylation-specific PCR (MSP), Western blot analysis, and quantitative real-time PCR were used to investigate the methylation status of the RECK gene and expression of RECK mRNA and protein in SACC cell lines. The invasive ability of SACC cells was examined by the Transwell migration assay. Promoter methylation was only found in the ACC-M cell line. Treatment of ACC-M cells with 5-aza-dC partially reversed the hypermethylation status of the RECK gene and significantly enhanced the expression of mRNA and protein, and 5-aza-dC significantly suppressed ACC-M cell invasive ability. Our findings showed that 5-aza-dC inhibited cancer cell invasion through the reversal of RECK gene hypermethylation, which might be a promising chemotherapy approach in SACC treatment.

  2. Increased numbers of P63-positive/CD117-positive cells in advanced adenoid cystic carcinoma give a poorer prognosis

    Directory of Open Access Journals (Sweden)

    Zhou Quan

    2012-09-01

    Full Text Available Abstract Objectives This study consisted of two parts. One part was to analyze the survival rates of adenoid cystic carcinoma (ACC in Chinese and explain the difference between our data and the literature. The other was to analyze the relationship between the expression of CD117 and the histological grade and the prognosis. Methods A retrospective study of 80 ACC patients was performed. Clinical data were collected, and p63, CD117 were detected by immunohistochemical staining. Results Eighty patients received follow-ups 3 to 216?months after initial diagnosis. ACC occurred in the lacrimal gland (26.3%, n?=?21, nasal cavity and parasinus (33.8%, n?=?27 and other sites (40.0%, n?=?33. The 5-year and 10-year survival rates were 66.41% and 10.16%, respectively. Over expression of CD117 was detected in p63-negative cells in 94.3% of cases and in p63-positive cells in 45.8%. The expression of CD117 in p63-positive cells was significantly associated with the histological grade (P Conclusions ACC had a good 5-year survival but poor 10-year survival in Chinese, which differed from the occidental data. More p63+/CD117+ cells were associated with a higher histological grade and poorer outcome. Virtual slides The virtual slide(s for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1701457278762097

  3. International collaborative validation of intraneural invasion as a prognostic marker in adenoid cystic carcinoma of the head and neck

    DEFF Research Database (Denmark)

    Amit, Moran; Binenbaum, Yoav

    2015-01-01

    BACKGROUND: The purpose of this study was to characterize the incidence, pattern of spread, and prognostic correlation of nerve invasion in patients with adenoid cystic carcinoma (ACC). METHODS: Using 3 different pathological categories of perineural invasion, intraneural invasion, and perineural inflammation, we investigated the prognostic value of nerve invasion in a total of 495 ACCs from 9 international patient cohorts with median follow-up 90 months (range, 12-288 months). RESULTS: Of 239 patients (48%) with nerve invasion, 174 (73%) had perineural invasion, 65 (27%) intraneural invasion, and 37 (15%) perineural inflammation. Multivariate Cox regression analysis identified tumor site (p = .008; hazard ratio [HR] = 1.8; 95% confidence interval [CI] = 0.07-3.7) and intraneural invasion (p < .001; HR = 5.9; 95% CI = 0.8-12.3) as independent prognostic markers for both overall survival (OS) and disease-specific survival (DSS), but not of distant metastases. CONCLUSION: Although perineural invasion has no impact on survival, intraneural invasion is an independent predictor of poor prognosis. Recognition of intraneural invasion may help optimize treatment of patients with head and neck ACC. © 2014 Wiley Periodicals, Inc. Head Neck, 2014.

  4. Efficacy of sorafenib, a multi-tyrosine kinase inhibitor, in an adenoid cystic carcinoma metastatic to the lung: case report and review of literature

    Directory of Open Access Journals (Sweden)

    Santos Edgardo S

    2011-09-01

    Full Text Available Abstract Introduction Treatment for squamous cell carcinoma of the head and neck has significantly improved with the addition of cetuximab, a monoclonal antibody against the epidermal growth factor receptor, to conventional cytotoxic agents. The most significant aspect of this treatment approach is the proof that head and neck cancers are suitable for targeted therapies as has been shown in other malignancies. Unfortunately, there are other rare histologic types of head and neck cancer such as adenocarcinoma and adenoid cystic carcinoma. The latter has traditionally been considered to be chemotherapy resistant and surgical resection with or without adjuvant radiation therapy has been the rule as far as treatment is concerned. The course of adenoid cystic carcinoma ranges from indolent to aggressive; however, most patients succumb to the disease as a result of distant metastases. This clinical scenario poses a challenge to oncologists. Several conventional chemotherapy regimens and novel targeted agents have been tried in this rare histologic subtype without success. Case presentation In this case report, we present a 59-year-old Caucasian female with refractory adenoid cystic carcinoma of the maxilla metastatic to the lung that responded to sorafenib, a novel multi-tyrosine kinase inhibitor, which targets angiogenesis, Raf kinase pathway, platelet-derived growth factor Ret, and c-Kit. Conclusion This case illustrates the possibility that this chemoresistant tumor may need the inhibition or blocking of several oncogenic pathways. Certainly, it is imperative that more studies are done in this special population trying to identify tumorigenesis mechanisms that may be upregulated in this malignancy and could be potential targets for therapeutic development.

  5. Expression of beclin 1 in primary salivary adenoid cystic carcinoma and its relation to Bcl-2 and p53 and prognosis

    OpenAIRE

    Jiang, L. C.; Huang, S. Y.; Zhang, D. S.; Zhang, S. H.; Li, W. G.; Zheng, P. H.; Chen, Z. W.

    2014-01-01

    Beclin 1 plays a critical role in autophagy and functions as a haploinsufficient tumor suppressor. The expression and prognostic significance of beclin 1 in head and neck adenoid cystic carcinoma (ACC) are largely unexplored. Therefore, we investigated the expression of beclin 1, Bcl-2, and p53 in head and neck ACC tissue. Tissue samples from 35 cases (15 females, 20 males) of head and neck ACC were utilized for immunohistochemistry. Beclin 1 expression was observed in 32 cases (91.4%) and co...

  6. Lacrimal gland adenoid cystic carcinoma with high-grade transformation to myoepithelial carcinoma: report of a case and review of literature.

    Science.gov (United States)

    Argyris, Prokopios P; Pambuccian, Stefan E; Cayci, Zuzan; Singh, Charanjeet; Tosios, Konstantinos I; Koutlas, Ioannis G

    2013-03-01

    Adenoid cystic carcinoma (AdCC) is the most frequent malignant neoplasm of the lacrimal glands. Like its salivary gland counterpart, lacrimal AdCC can rarely undergo high-grade transformation ("dedifferentiation"). We herein report the clinical, radiographic and microscopic findings of a lacrimal gland AdCC with high grade transformation, occurring in a 39-year-old female patient. In contrast to salivary gland AdCC with high-grade transformation, which usually shows a high grade component with "ductal" differentiation, in the case presented, the "dedifferentiated" component showed morphologic and immunohistochemical features of myoepithelial differentiation. PMID:22829347

  7. Therapeutic strategies for adenoid cystic carcinoma of the nasal and paranasal sinus from the long-term treatment results

    Energy Technology Data Exchange (ETDEWEB)

    Terada, Nobuhisa; Numata, Tsutomu; Mutoh, Hiroyuki; Ueki, Yuji; Gorai, Shigeki; Konno, Akiyoshi [Chiba Univ. (Japan). School of Medicine

    2001-03-01

    This article presents long-term treatment results by analyzing 24 cases with adenoid cystic carcinoma (ACC) of the nasal and paranasal sinus treated from 1975 to 1995 at Akita University Hospital and Chiba University Hospital. The basic strategies for treatment for ACC of the nasal and paranasal sinuses are en bloc tumor resection, followed by primary reconstruction of the maxilla. Preoperative and postoperative radiation were combined. Cumulative 5-year and 10-year survival rates were 70.6% and 47.1% for maxillary sinus tumors, respectively. Cumulative 5-year and 10-year survival rates for nasal tumors were 100% and 75.0%, and those for sphenoid sinus tumors were 50.0% and 0%, respectively. The patient with ethomoid sinus who needed skull base surgery is alive at 8.1 years after therapy. Treatment results closely correlated with tumor extension. Cumulative 5-year survival rates for T2, T3 and, T4 patients with maxillary sinus tumors were 85.7%, 71.4%, and 33.3%, respectively. And cumulative 10-year survival rates for T2, T3, and T4 were 71.4%, 42.9%, and 0%, respectively. The histopathological effects of preoperative radiation were Shimosato II a in 6 out of 10 patients, II b in 2, and III in 2, respectively. Only fast neutron therapy reached Shimosato III. Two of the patients with Shimosato II a died of distant metastasis. The above data suggests that, although radiation therapy alone cannot cure tumors, preoperative full-dose radiation may prevent the development of distant metastasis if it can achieve histopathological effects of a higher classification than Shimosato II b. Because chemotherapy and radiation is not very effective on ACC, the role of skull base surgeries for nasal-paranasal sinus malignancies that invade the skull base is valuable, particularly in cases having a relatively small mass in the ethmoid sinus. (author)

  8. Therapeutic strategies for adenoid cystic carcinoma of the nasal and paranasal sinus from the long-term treatment results

    International Nuclear Information System (INIS)

    This article presents long-term treatment results by analyzing 24 cases with adenoid cystic carcinoma (ACC) of the nasal and paranasal sinus treated from 1975 to 1995 at Akita University Hospital and Chiba University Hospital. The basic strategies for treatment for ACC of the nasal and paranasal sinuses are en bloc tumor resection, followed by primary reconstruction of the maxilla. Preoperative and postoperative radiation were combined. Cumulative 5-year and 10-year survival rates were 70.6% and 47.1% for maxillary sinus tumors, respectively. Cumulative 5-year and 10-year survival rates for nasal tumors were 100% and 75.0%, and those for sphenoid sinus tumors were 50.0% and 0%, respectively. The patient with ethomoid sinus who needed skull base surgery is alive at 8.1 years after therapy. Treatment results closely correlated with tumor extension. Cumulative 5-year survival rates for T2, T3 and, T4 patients with maxillary sinus tumors were 85.7%, 71.4%, and 33.3%, respectively. And cumulative 10-year survival rates for T2, T3, and T4 were 71.4%, 42.9%, and 0%, respectively. The histopathological effects of preoperative radiation were Shimosato II a in 6 out of 10 patients, II b in 2, and III in 2, respectively. Only fast neutron therapy reached Shimosato III. Two of the patients with Shimosato II a died of distant metastasis. The above data suggests that, although radiation therapy alone cannot cure tumors, preoperative full-dose radiation may prevent the development ose radiation may prevent the development of distant metastasis if it can achieve histopathological effects of a higher classification than Shimosato II b. Because chemotherapy and radiation is not very effective on ACC, the role of skull base surgeries for nasal-paranasal sinus malignancies that invade the skull base is valuable, particularly in cases having a relatively small mass in the ethmoid sinus. (author)

  9. Adenoid cystic carcinoma with high-grade transformation: a report of 11 cases and a review of the literature.

    Science.gov (United States)

    Seethala, Raja R; Hunt, Jennifer L; Baloch, Zubair W; Livolsi, Virginia A; Leon Barnes, E

    2007-11-01

    High-grade transformation of adenoid cystic carcinoma (ACC) (previously referred to as dedifferentiation) is a rare phenomenon that does not fit into the traditional ACC grading schemes. The importance and minimal criteria for distinction from solid (grade III) ACC are not well established. We report 11 new cases and review the literature to further define the profile of this tumor. The median age was 61 years (range: 32 to 72 y) with a male predominance (male to female ratio of 1.75:1). The most commonly involved sites were sinonasal (4/11) and submandibular (4/11). Lymph nodes were pathologically positive in 4/7 (57.1%) cases. Distant metastases to the lung (n=2) and soft tissue of the shoulder (n=1) were observed. Five of 9 patients (55.6%) died, all within 5 years with a median overall survival of 12 months. Histologically, ACC with high-grade transformation was distinguished from conventional ACC by nuclear enlargement and irregularity, higher mitotic counts, and the loss of the biphasic ductal-myoepithelial differentiation. Useful supportive criteria were prominent comedonecrosis and fibrocellular desmoplasia. The most common morphologies for the high-grade component were poorly differentiated cribriform adenocarcinoma and solid undifferentiated carcinoma. Micropapillary and squamoid patterns were occasionally present. Ki-67 and p53 labeling indices were elevated in the high-grade components, though c-kit and cyclin-D1 were not. ACC-high-grade transformation is a highly aggressive salivary gland tumor with a variety of histologic patterns. The high propensity for lymph node metastases suggests a role for neck dissection in patients with this rare tumor. PMID:18059225

  10. Combined treatment of adenoid cystic carcinoma with cetuximab and IMRT plus C12 heavy ion boost: ACCEPT [ACC, Erbitux® and particle therapy

    Directory of Open Access Journals (Sweden)

    Hinke Axel

    2011-02-01

    Full Text Available Abstract Background Local control in adjuvant/definitive RT of adenoid cystic carcinoma (ACC is largely dose-dependent leading to the establishment of particle therapy in this indication. However, even modern techniques leave space for improvement of local control by intensification of local treatment. Radiation sensitization by exploitation of high EGFR-expression in ACC with the EGFR receptor antibody cetuximab seems promising. Methods/design The ACCEPT trial is a prospective, mono-centric, phase I/II trial evaluating toxicity (primary endpoint: acute and late effects and efficacy (secondary endpoint: local control, distant control, disease-free survival, overall survival of the combined treatment with IMRT/carbon ion boost and weekly cetuximab in 49 patients with histologically proven (?R1-resected, inoperable or Pn+ ACC. Patients receive 18 GyE carbon ions (6 fractions and 54 Gy IMRT (2.0 Gy/fraction in combination with weekly cetuximab throughout radiotherapy. Discussion The primary objective of ACCEPT is to evaluate toxicity and feasibility of cetuximab and particle therapy in adenoid cystic carcinoma. Trial Registration Clinical Trial Identifier: NCT 01192087 EudraCT number: 2010 - 022425 - 15

  11. Carcinoma adenoideo quístico de la próstata: Presentación de 2 casos / Cystic adenoid carcinoma of the prostate: Report of two cases

    Scientific Electronic Library Online (English)

    Isis E., Pedro Silva; Vicente, Osorio Acosta; F. Albaro, Farfán Chávez.

    2006-10-01

    Full Text Available SciELO Spain | Language: Spanish Abstract in spanish Objetivo: Presentamos dos casos con diagnóstico histológico de carcinoma adenoideo quístico de la próstata, tumor de presentación extremadamente raro. Métodos: Evaluamos a dos pacientes con edad de presentación, manifestación clínica, diagnóstico, tratamiento y evolución distintos. Resultados: La ed [...] ad varia de 41 y 59 años, con dolor perineal y sintomatología urinaria baja, tacto rectal masa tumoral redondeada y dura o normal respectivamente. El antígeno prostático específico y la fosfatasa ácida prostática son normales, el ultrasonido transrectal puede ser normal o aportar con el hallazgo de nódulo hipoecoico, se realizó tratamiento quirúrgico con prostatectomía radical e inmunoterapia adyuvante en el primero que a los 6 años evoluciona a metastasis pulmonar y muere, el otro cistoprostatectomía radical con derivación urinaria ortotópica con buena evolución a los dos años. Conclusiones: La clínica es inespecífica, generalmente el diagnóstico es mediante resección transuretral o biopsia transrectal ante la sospecha por tacto rectal o ultrasonido, es inmunoreactivo para p53 y citoqueratinas 7 y 34 beta E12 y el tratamiento de elección es la cistoprostatectomía radical debido a que es una neoplasia potencialmente agresiva y puede añadirse tratamiento adyuvante. Abstract in english Objective: We report two cases with the pathologic diagnosis of cystic adenoid carcinoma of the prostate, an extremely rare tumor. Methods: We evaluate two patients with different age, clinical presentation, diagnosis, treatment and outcome. Results: The ages were 41 and 59, the symptoms perineal pa [...] in and lower urinary tract symptoms, on digital rectal examination a round hard tumor mass and normal exam, respectively. PSA and prostatic acid phosphatase were normal; Transrectal ultrasound may be normal or find a hypoechoic node. The first patient underwent radical prostatectomy and adjuvant immunotherapy; six years after surgery he developed lung metastasis and died. The second patient underwent radical cystoprostatectomy with orthotopic urinary diversion with good outcome after two years of follow-up. Conclusions: The clinical presentation is non specific, with the diagnosis generally obtained by transurethral resection or transrectal biopsy after the suspicion of an abnormal digital rectal examination or ultrasound. The tumor is immunoreactive to p53 and citokeratins 7 and 34 Beta E12, and the treatment of choice is radical cystoprostatectomy because it is a potentially aggressive neoplasia; adjuvant treatment may be added.

  12. Estudo clínico, randomizado, duplo-cego, em crianças com adenóide obstrutiva, submetidas a tratamento homeopático / Prospective, randomized, double-blind clinical trial about efficacy of homeopathic treatment in children with obstructive adenoid

    Scientific Electronic Library Online (English)

    Sergio E., Furuta; Luc L.M., Weckx; Claudia R., Figueiredo.

    2003-06-01

    Full Text Available OBJETIVO: Avaliar a eficácia e segurança do tratamento homeopático em crianças com adenóide obstrutiva, com indicação cirúrgica. FORMA DE ESTUDO: Clínico prospectivo. Material e método: Estudo prospectivo, duplo-cego, randomizado, em que foram incluídas 40 crianças com idade variando de 3 a 7 anos, [...] 20 crianças foram tratadas com medicação homeopática individualizada (Simillimum), baseada no princípio da similitude e 20 crianças receberam placebo. Todas as crianças do grupo medicação homeopática foram medicadas diariamente com Agraphis nutans 6 CH, Thuya 6 CH e Adenóide 21CH; e as do grupo placebo receberam diariamente medicamentos sem o princípio ativo. A duração do estudo de cada paciente foi de 4 meses. A avaliação dos resultados foi clínica, por meio de questionário padrão, de exame otorrinolaringológico e nasofaringoscopia direta com fibroscópio flexível, no primeiro e no último dia de tratamento. Utilizou-se como critério de inclusão a adenóide que ocupou mais do que 70% da luz coanal. RESULTADOS: Das 20 crianças tratadas com medicamento homeopático, 13 não apresentaram alteração no tamanho da adenóide nos exames nasofaringoscópicos e 7 tiveram diminuição da adenóide; das 20 crianças que receberam placebo por 4 meses, 11 não apresentaram alterações no tamanho da adenóide, 4 tiveram diminuição da adenóide e 5 crianças tiveram aumento. Não houve diferença estatística significante entre os grupos (P= 0,069). Na avaliação clínica da evolução dos pacientes, dos 20 pacientes tratados com medicamento homeopático, 17 se mantiveram inalterados, com respiração oral e ronco, um paciente melhorou, ficando sem ronco e dois foram curados, isto é, a respiração alterou-se de oral para nasal e sem ronco. Dos 20 pacientes tratados com placebo, 17 pacientes se mantiveram inalterados, um paciente melhorou do ronco e dois foram curados, não tendo havido diferença estatística significante entre os grupos (P>0,999). CONCLUSÕES: O tratamento homeopático não foi eficaz nas crianças com adenóide obstrutiva, mantendo-se a indicação cirúrgica em 85% dos pacientes. O medicamento homeopático não provocou eventos adversos nas crianças. Abstract in english AIM: the efficacy and security of homeopathic treatment was investigated on children with obstructive adenoid justifying an operation. STUDY DESIGN: Clinical prospective. MATERIAL AND METHOD: In a prospective, randomized, double-blind clinical trial included 40 children between the ages of 3 to 7 ye [...] ars old, 20 children were treated with homeopathic medication, based in the principle of similarity (Simillimum), and 20 children with placebo. All the children of the homeopathic group/ adenoid, were treated daily with Agraphis nutans 6 CH, Thuya 6 CH and Adenoid 21CH, and the patients of the placebo group received daily placebo medication. The duration of the study of each children was 4 months. The evaluation of the results was clinical, and it was made by questionnaire standard, clinical examination and direct flexible fiberoptic nasopharyngoscopy, in the first and last day of treatment. The criterion of selection was the adenoid that occuped more than 70% of the coanal space. RESULTS: From the group of 20 children treated with homeopathic treatment, 13 did not show any change on the size of adenoid after nasopharyngoscopy, and 7 children had their adenoid decreased; from another group of 20 children that have treated with placebo for 4 months, 11 did not show any change on the size of their adenoid, 4 had their adenoid decreased and 5 had their adenoid increased. The statistical analysis showed a not significant difference (P= 0,069). The clinical evaluation of the patients showed that from the group of 20 patients treated with homeopathy, 17 kept unchanging, with oral breathing and snoring, one patient got better, eliminating the snoring and two were cured, which mean that their oral breathing turned to nasal breathing without snoring. From the group of 20 patients treated with p

  13. Carcinoma adenóide cístico: revisão da literatura e relato de caso clínico / Adenoid cystic carcinoma: review of the literature and case report

    Scientific Electronic Library Online (English)

    Adriana Terezinha N. N., Alves; Flávia Dantas, Soares; Arley, Silva Junior; Ney, Medeiros; Adrianna, Milagres.

    2004-12-01

    Full Text Available O carcinoma adenóide cístico (CAC) é neoplasia maligna de glândula salivar que acomete principalmente as glândulas parótidas, as submandibulares e as salivares acessórias, sendo raro nas glândulas sublinguais. Com crescimento lento e natureza infiltrativa, clinicamente apresenta-se como nódulo de co [...] nsistência endurecida. O presente trabalho teve como objetivo revisar a literatura atual sobre o tema em relação aos aspectos clínicos e histopatológicos, bem como relatar um caso de CAC na região submandibular. Abstract in english The adenoid cystic carcinoma (ACC) is a malignant neoplasm of salivary gland that arises preferencially in parotid glands, submandibular and minor salivary glands, but is uncommon in sublingual glands. The ACC is a slow growth and infiltrative tumour that clinically is characterized by a firm mass. [...] The present study aims to rewiew the atually literature of the ACC in relation of clinical and histopathological features and describes a case of ACC in submandibular gland.

  14. Incidence of cervical lymph node metastasis and its association with outcomes in patients with adenoid cystic carcinoma. An international collaborative study

    DEFF Research Database (Denmark)

    Amit, Moran; Binenbaum, Yoav

    2015-01-01

    BACKGROUND: The patterns of regional metastasis in adenoid cystic carcinoma (ACC) of the head and neck and its association with outcome is not established. METHODS: We conducted a retrospective multicentered multivariate analysis of 270 patients who underwent neck dissection. RESULTS: The incidence rate of neck metastases was 29%. The rate observed in the oral cavity is 37%, and in the major salivary glands is 19% (p = .001). The rate of occult nodal metastases was 17%. Overall 5-year survival rates were 44% in patients undergoing therapeutic neck dissections, and 65% and 73% among those undergoing elective neck dissections, with and without nodal metastases, respectively (p = .017). Multivariate analysis revealed that the primary site, nodal classification, and margin status were independent predictors of survival. CONCLUSION: Our findings support the consideration of elective neck treatment in patients with ACC of the oral cavity. © 2014 Wiley Periodicals, Inc. Head Neck, 2014.

  15. All about Adenoids

    Science.gov (United States)

    ... can breathe only through his or her mouth snoring and trouble getting a good night's sleep sore ... THIS TOPIC Tonsillitis Having Your Tonsils Taken Out Snoring When Sinuses Attack! The Scoop on Strep Throat ...

  16. The influence of positive margins and nerve invasion in adenoid cystic carcinoma of the head and neck treated with surgery and radiation

    International Nuclear Information System (INIS)

    Purpose: Surgery is the primary treatment for adenoid cystic carcinomas arising from major and minor salivary glands of the head and neck. However, local recurrence is frequent because of the infiltrative growth pattern and perineural spread associated with these tumors. At UTMDACC, we have had a long-standing policy of using postoperative radiotherapy to reduce the risk of local recurrence and to avoid the need for radical surgery; this 30-year retrospective study analyzes the results of this combined modality approach. Methods and Materials: Between 1962 and 1991, 198 patients ages 13-82 years, with adenoid cystic carcinomas of the head and neck, received postoperative radiotherapy for known or suspected microscopic residual disease following surgery. Distribution of primary sites was: parotid: 30 patients; submandibular/sublingual: 41 patients; lacrimal: 5 patients; and minor salivary glands: 122 patients. Eighty-three patients (42%) had microscopic positive margins and an additional 55 (28%) had close (?5 mm) or uncertain margins. One hundred thirty-six patients (69%) had perineural spread with invasion of a major (named) nerve in 55 patients (28%). Using radiation techniques appropriate to the primary site, a median dose of 60 Gy (range 50-69 Gy) was delivered to the tumor bed. Follow-up ranged from 5-341 months (median, 93 months). All surviving patients had a minimum of 2 years follow-up. Results: Twenty-three patients (12%) had local recurrences with 5-, 10-(12%) had local recurrences with 5-, 10-, and 15-year actuarial local control rates of 95%, 86%, and 79%, respectively. Fifteen of the 83 patients (18%) with positive margins developed local recurrences, compared to 5 of 55 patients (9%) with close or uncertain margins, and 3 of 60 patients (5%) with negative margins (p 0.02). Patients with and without a major (named) nerve involved had crude failure rates of 18% (10 out of 55) and 9% (13 out of 143), respectively (p 0.02). There was a trend toward better local control with increasing dose. This was significant in patients with positive margins, in whom crude control rates were 40 and 88% for doses of <56 Gy and ?56 Gy, respectively (p 0.006). Actuarial 5-, 10-, and 15-year freedom from relapse rates were 68%, 52%, and 45%, respectively. Base of skull and neck failures were uncommon with or without elective treatment, developing in 2 and 3% of patients, respectively. Distant metastases were the most common type of disease recurrence, developing in 74 patients (37%) of whom 62 (31%) were disease-free at the primary site. Conclusions: Excellent local control rates were obtained in this population using surgery and postoperative radiotherapy and we recommend this combined approach for most patients with adenoid cystic carcinomas of the head and neck. Perineural invasion was an adverse prognostic factor only when a major (named) nerve was involved. Microscopic positive margins was also an adverse prognostic factor, but even when present, local control was achieved in over 80% of our patients. We recommend a dose of 60 Gy to the tumor bed, supplemented to 66 Gy for patients with positive margins. Despite effective local therapy, one-third of patients fail systemically, and good treatment to address this problem is lacking

  17. Avaliação da pressão inspiratória em crianças com aumento do volume de tonsilas Evaluation of inspiratory pressure in children with enlarged tonsils and adenoids

    Directory of Open Access Journals (Sweden)

    Melissa Guerato Pires

    2005-10-01

    Full Text Available Crianças com aumento do volume de tonsilas palatina e faríngea freqüentemente apresentam anormalidades respiratórias tais como ronco, respiração oral e apnéia do sono. Sabe-se que a obstrução de vias aéreas superiores e conseqüentemente a respiração oral podem resultar em problemas pulmonares. OBJETIVO: Avaliar a pressão inspiratória em crianças com obstrução de vias aéreas superiores devido ao aumento do volume de tonsilas. FORMA DE ESTUDO: clínico com coorte transversal. MATERIAL E MÉTODO: Nós avaliamos 37 crianças (4-13 anos, ambos os sexos com aumento do volume de tonsilas que seriam submetidas à cirurgia de Adenoamigdalectomia na Divisão de Otorrinolaringologia da Universidade de São Paulo no mesmo período. O grupo controle foi composto de 28 crianças sem aumento de volume tonsilar que foram submetidas aos mesmos testes. A pressão Inspiratória foi obtida pelo uso do manovacuômetro. RESULTADOS: Observamos uma menor pressão inspiratória no grupo com aumento do volume de tonsilas. A média do grupo com aumento do volume das tonsilas foi 14,607 cm/H2O e do grupo normal foi de 27,580 cm/H2O (PChildren with enlarged tonsils and adenoids usually present breathing abnormalities such as snoring, mouth breathing and sleep apnea. It is known that upper airway obstruction and consequent mouth breathing may result in pulmonary diseases. AIM: The goal of this preliminary study was to evaluate the inspiratory pressure in children with upper airway obstruction due to enlarged tonsils. STUDY DESIGN: clinical with transversal cohort. MATERIAL AND METHOD: We evaluated 37 children (4 -13 years old, female/male with enlarged tonsils who would be submitted to a T&A surgery in the Department of Otolaryngology, Medical School, University of Sao Paulo, from October 2002 to March 2003. The control group comprised 28 children without tonsillar disease submitted to the same tests. Inspiratory pressure was obtained using a manometer and vacuum meter. RESULTS: We could observe lower inspiratory pressures in children with upper airway obstruction. The mean of inspiratory pressure in the upper airway obstruction group was 14.607cm/H2O and in the control group was of 27.580cm/H2O. CONCLUSIONS: Enlarged tonsils and adenoids were associated with poor inspiratory pressure, resulting in increased breathing effort and work of the involved muscles.

  18. Avaliação da pressão inspiratória em crianças com aumento do volume de tonsilas / Evaluation of inspiratory pressure in children with enlarged tonsils and adenoids

    Scientific Electronic Library Online (English)

    Melissa Guerato, Pires; Renata Cantisani, Di Francesco; Anete Sevciovic, Grumach; João Ferreira de, Mello Jr..

    2005-10-01

    Full Text Available Crianças com aumento do volume de tonsilas palatina e faríngea freqüentemente apresentam anormalidades respiratórias tais como ronco, respiração oral e apnéia do sono. Sabe-se que a obstrução de vias aéreas superiores e conseqüentemente a respiração oral podem resultar em problemas pulmonares. OBJET [...] IVO: Avaliar a pressão inspiratória em crianças com obstrução de vias aéreas superiores devido ao aumento do volume de tonsilas. FORMA DE ESTUDO: clínico com coorte transversal. MATERIAL E MÉTODO: Nós avaliamos 37 crianças (4-13 anos, ambos os sexos) com aumento do volume de tonsilas que seriam submetidas à cirurgia de Adenoamigdalectomia na Divisão de Otorrinolaringologia da Universidade de São Paulo no mesmo período. O grupo controle foi composto de 28 crianças sem aumento de volume tonsilar que foram submetidas aos mesmos testes. A pressão Inspiratória foi obtida pelo uso do manovacuômetro. RESULTADOS: Observamos uma menor pressão inspiratória no grupo com aumento do volume de tonsilas. A média do grupo com aumento do volume das tonsilas foi 14,607 cm/H2O e do grupo normal foi de 27,580 cm/H2O (P Abstract in english Children with enlarged tonsils and adenoids usually present breathing abnormalities such as snoring, mouth breathing and sleep apnea. It is known that upper airway obstruction and consequent mouth breathing may result in pulmonary diseases. AIM: The goal of this preliminary study was to evaluate the [...] inspiratory pressure in children with upper airway obstruction due to enlarged tonsils. STUDY DESIGN: clinical with transversal cohort. MATERIAL AND METHOD: We evaluated 37 children (4 -13 years old, female/male) with enlarged tonsils who would be submitted to a T&A surgery in the Department of Otolaryngology, Medical School, University of Sao Paulo, from October 2002 to March 2003. The control group comprised 28 children without tonsillar disease submitted to the same tests. Inspiratory pressure was obtained using a manometer and vacuum meter. RESULTS: We could observe lower inspiratory pressures in children with upper airway obstruction. The mean of inspiratory pressure in the upper airway obstruction group was 14.607cm/H2O and in the control group was of 27.580cm/H2O. CONCLUSIONS: Enlarged tonsils and adenoids were associated with poor inspiratory pressure, resulting in increased breathing effort and work of the involved muscles.

  19. Expression of beclin 1 in primary salivary adenoid cystic carcinoma and its relation to Bcl-2 and p53 and prognosis

    Scientific Electronic Library Online (English)

    L.C., Jiang; S.Y., Huang; D.S., Zhang; S.H., Zhang; W.G., Li; P.H., Zheng; Z.W., Chen.

    2014-03-01

    Full Text Available Beclin 1 plays a critical role in autophagy and functions as a haploinsufficient tumor suppressor. The expression and prognostic significance of beclin 1 in head and neck adenoid cystic carcinoma (ACC) are largely unexplored. Therefore, we investigated the expression of beclin 1, Bcl-2, and p53 in [...] head and neck ACC tissue. Tissue samples from 35 cases (15 females, 20 males) of head and neck ACC were utilized for immunohistochemistry. Beclin 1 expression was observed in 32 cases (91.4%) and considered to be high in 15 cases (42.9%) and low in 20 cases (57.1%). Beclin 1 expression was significantly correlated with a histological growth pattern (P=0.046) and histological grade (P=0.037). Beclin 1 expression was inversely correlated with Bcl-2 expression (P=0.013) and significantly associated with overall survival (P=0.006). Bcl-2 and p53 expression were observed in 21 cases (60.0%) and 16 cases (45.7%). Bcl-2 expression was significantly correlated with perineural invasion (P=0.041) and not associated with overall survival (P=0.053). p53 expression was directly correlated with beclin 1 expression (P=0.044). Our results indicated that beclin 1 may be a novel, promising prognostic factor for clinical outcome in head and neck ACC patients and may play a part in the development of head and neck ACC by interacting with Bcl-2 and p53.

  20. 18F-FDG PET/CT in Patients with Initially Diagnosed Adenoid Cystic Carcinoma of the Head and Neck: Clinicoplathologic Correlation

    International Nuclear Information System (INIS)

    We evaluated 18F-FDG PET/CT findings in initially diagnosed adenoid cystic carcinoma (ACC) of the head and neck in association with pathological subtype, staging, uptake comparison with squamous cell carcinoma (SqCC) and prognosis. The subjects were 16 patients with initially diagnosed ACC of head and neck who underwent pretreatment 18F-FDG PET/CT. Histological subtype (solid pattern vs. tubular/cribriform pattern), SUVmax of size-matched SqCC of the head and neck as control group, disease-free survival (DFS) were compared with the SUVmax of ACC of the head and neck. Of total 16 patients, 6 had solid pattern and the remaining 10 had tubular/cribriform pattern. The SUVmax were significantly higher in solid pattern group than in tubular/cribriform pattern group (6.7±3.2 vs. 4.2±0.9, p=0.03). PET/CT found unexpected distant metastasis in 18.7% of patients (3/16) and changed the therapeutic plan in those patients. The SUVmax of ACC was significantly lower than that of size-matched SqCC (5.1±2.4 vs. 13.6±6.0, p18F-FDG uptake (SUVmax ?6.0) had significantly shorter DFS than those with low 18F-FDG uptake (SUVmax 18F-FDG uptake of ACC of the head and neck is significantly associated with histological subtype and DFS. 18gical subtype and DFS. 18F-FDG PET/CT may be useful for detecting unexpected metastasis. Since 18F-FDG uptake of tubular/cribriform ACC compared with SqCC is relatively low, it is necessary to interpret PET images carefully in patients without alleged ACC

  1. Comprehensive genomic profiling of relapsed and metastatic adenoid cystic carcinomas by next-generation sequencing reveals potential new routes to targeted therapies.

    Science.gov (United States)

    Ross, Jeffrey S; Wang, Kai; Rand, Janna V; Sheehan, Christine E; Jennings, Timothy A; Al-Rohil, Rami N; Otto, Geoff A; Curran, John C; Palmer, Gary; Downing, Sean R; Yelensky, Roman; Lipson, Doron; Balasubramanian, Sohail; Garcia, Lazaro; Mahoney, Kristen; Ali, Siraj M; Miller, Vincent A; Stephens, Philip J

    2014-02-01

    We hypothesized that next-generation sequencing could reveal actionable genomic alterations (GAs) and potentially expand treatment options for patients with advanced adenoid cystic carcinoma (ACC). Genomic profiling using next-generation sequencing was performed on hybridization-captured, adapter ligation libraries derived from 28 relapsed and metastatic formalin-fixed paraffin-embedded ACC. The 3230 exons of 182 cancer-related genes and 37 introns of 14 genes frequently rearranged in cancer were fully sequenced using the Illumina HiSeq 2000. All classes of GAs were evaluated. Actionable GAs were defined as those impacting targeted anticancer therapies on the market or in registered clinical trials. A total of 44 GAs were identified in the 28 ACC tumors, with 12 of 28 (42.9%) of tumors harboring at least 1 potentially actionable GA. The most common nonactionable GAs were identified in KD6MA (5 cases; 18%), ARID1A (4 cases; 14%), RUNX1 (2 cases; 7%), and MYC (2 cases; 7%). Actionable GAs included NOTCH1 (3 cases; 11%), MDM2 (2 cases; 7%), PDGFRA (2 cases; 7%), and CDKN2A/B (p16) (2 cases; 7%). Other potentially actionable GAs identified in a single case included: mutations in AKT1, BAP1, EGFR, and PIK3CA, homozygous deletion of FBXW7, and amplifications of CDK4, FGFR1, IGF1R, KDR, KIT, and MCL1. The frequency of GA in ACC is lower than that seen in the more common solid tumors. Comprehensive genomic profiling of ACC can identify actionable GAs in a subset of patients that could influence therapy for these difficult-to-treat progressive neoplasms. PMID:24418857

  2. Mutations in the c-Kit Gene Disrupt Mitogen-Activated Protein Kinase Signaling during Tumor Development in Adenoid Cystic Carcinoma of the Salivary Glands

    Directory of Open Access Journals (Sweden)

    Osamu Tetsu

    2010-09-01

    Full Text Available The Ras/mitogen-activated protein kinase (MAPK pathway is considered to be a positive regulator of tumor initiation, progression, and maintenance. This study reports an opposite finding: we have found strong evidence that the MAPK pathway is inhibited in a subset of adenoid cystic carcinomas (ACCs of the salivary glands. ACC tumors consistently overexpress the receptor tyrosine kinase (RTK c-Kit, which has been considered a therapeutic target. We performed mutational analysis of the c-Kit gene (KIT in 17 cases of ACC and found that 2 cases of ACC had distinct missense mutations in KIT at both the genomic DNA and messenger RNA levels. These mutations caused G664R and R796G amino acid substitutions in the kinase domains. Surprisingly, the mutations were functionally inactive in cultured cells. We observed a significant reduction of MAPK (ERK1/2 activity in tumor cells, as assessed by immunohistochemistry. We performed further mutational analysis of the downstream effectors in the c-Kit pathway in the genes HRAS, KRAS, NRAS, BRAF, PIK3CA, and PTEN. This analysis revealed that two ACC tumors without KIT mutations had missense mutations in either KRAS or BRAF, causing S17N K-Ras and V590I B-Raf mutants, respectively. Our functional analysis showed that proteins with these mutations were also inactive in cultured cells. This is the first time that MAPK activity from the RTK signaling has been shown to be inhibited by gene mutations during tumor development. Because ACC seems to proliferate despite inactivation of the c-Kit signaling pathway, we suggest that selective inhibition of c-Kit is probably not a suitable treatment strategy for ACC.

  3. Revisão dos tumores da traqueia: A propósito de um caso clínico de tumor adenóide cístico / Tracheal tumors review: A clinical case of adenoid cystic carcinoma

    Scientific Electronic Library Online (English)

    António, Caiado; João Moura e, Sá.

    2008-07-01

    Full Text Available SciELO Portugal | Language: Portuguese Abstract in portuguese Os tumores primários da traqueia são raros, representando apenas 0,3% de todos os tumores. A incidência destes tumores é inferior a 0,2 por 100 000 habitantes e 180 vezes menos frequente do que os tumores do pulmão. O porquê da sua raridade permanece por explicar. Possivelmente o fluxo turbulento na [...] traqueia protege a mucosa do depósito de carcinogénios inalatórios. Os autores apresentam um caso clínico de um tumor adenóide cístico da traqueia em mulher de 23 anos, não fumadora, e com quadro agudo de estridor inspiratório onde a utilização do laser Nd-Yag foi de primordial importância, permitindo uma exérese parcial alargada e segura da massa tumoral que fazia obstrução de 80% do lúmen da traqueia, conseguindo a repermeabilização rápida da via aérea principal, evitando um quadro asfíxico iminente, enquanto a doente aguardava cirurgia. Abstract in english Tracheal tumours are rare, accounting for only about 0.3% of all bodily tumours. Their incidence is less than 0.2 per 100 000 inhabitants and 180 times less frequent than lung cancer. The reason for their rarity is not so clear. It is possible that turbulent airflow in the trachea protects its mucos [...] a from inhaled carcinogen deposits. The authors report a case of adenoid cystic carcinoma in a 23 year-old woman, non-smoker, with acute clinical inspiratory stridor, where Nd-Yag laser use was extremely important to tracheal permeability as the tumor occupied over 80% of the tracheal lumen and could have led to imminent patient asphyxia.

  4. Expression of alveolar type II cell markers in acinar adenocarcinomas and adenoid cystic carcinomas arising from segmental bronchi. A study in a heterotopic bronchogenic carcinoma model in dogs.

    Science.gov (United States)

    TenHave-Opbroek, A. A.; Hammond, W. G.; Benfield, J. R.; Teplitz, R. L.; Dijkman, J. H.

    1993-01-01

    The type II alveolar epithelial cell is one of two pluripotential stem cell phenotypes in normal mammalian lung morphogenesis; cells manifesting this phenotype have been found to constitute bronchioloalveolar regions of canine adenocarcinomas. We now studied type II cell expression in canine acinar adenocarcinomas and adenoid cystic (bronchial gland) carcinomas, using the same bronchogenic carcinoma model (subcutaneous bronchial autografts treated with 3-methylcholanthrene). Distinctive features of type II cells are the approximately cuboid cell shape, large and roundish nucleus, immunofluorescent staining of the cytoplasm for the surfactant protein SP-A, and presence of multilamellar bodies or their precursory forms. Cells with these type II cell characteristics were found in the basal epithelial layer of all tumor lesions and in upper layers as far as the lumen, singly or in clusters; they were also found in early invasive carcinomatous lesions but not in bronchial glands or bronchial epithelium before carcinogen exposure. Immunoblots of tumor homogenates showed reactive proteins within size classes of SP-A (28 to 36 kd) or its dimeric form (56 to 72 kd). These findings and those previously reported are consistent with the concept that chemical carcinogenesis in the adult bronchial epithelium may lead to type II cell carcinomas of varying glandular (acinar, adenoidcystic or bronchioloalveolar) growth patterns. Images Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 Figure 6 Figure 7 Figure 8 Figure 9 Figure 10 Figure 11 Figure 12 Figure 13 Figure 14 Figure 15 Figure 16 Figure 17 Figure 18 Figure 19 Figure 20 Figure 21 Figure 22 PMID:8386445

  5. c-Kit Expression is Rate-Limiting for Stem Cell Factor-Mediated Disease Progression in Adenoid Cystic Carcinoma of the Salivary Glands.

    Science.gov (United States)

    Phuchareon, Janyaporn; van Zante, Annemieke; Overdevest, Jonathan B; McCormick, Frank; Eisele, David W; Tetsu, Osamu

    2014-10-01

    Adenoid cystic carcinoma (ACC) is an aggressive malignant neoplasm of the salivary glands in which c-Kit is overexpressed and activated, although the mechanism for this is as yet unclear. We analyzed 27 sporadic ACC tumor specimens to examine the biologic and clinical significance of c-Kit activation. Mutational analysis revealed expression of wild-type c-Kit in all, eliminating gene mutation as a cause of activation. Because stem cell factor (SCF) is c-Kit's sole ligand, we analyzed its expression in the tumor cells and their environment. Immunohistochemistry revealed its presence in c-Kit-positive tumor cells, suggesting an activation of autocrine signaling. We observed a significant induction of ERK1/2 in the cells. SCF staining was also found in other types of non-cancerous cells adjacent to tumors within salivary glands, including stromal fibroblasts, neutrophils, peripheral nerve, skeletal muscle, vascular endothelial cells, mucous acinar cells, and intercalated ducts. Quantitative PCR showed that the top quartile of c-Kit mRNA expression distinguished ACCs from normal salivary tissues and was cross-correlated with short-term poor prognosis. Expression levels of SCF and c-Kit were highly correlated in the cases with perineural invasion. These observations suggest that c-Kit is potentially activated by receptor dimerization upon stimulation by SCF in ACC, and that the highest quartile of c-Kit mRNA expression could be a predictor of poor prognosis. Our findings may support an avenue for c-Kit-targeted therapy to improve disease control in ACC patients harboring the top quartile of c-Kit mRNA expression. PMID:25389449

  6. c-Kit Expression is Rate-Limiting for Stem Cell Factor-Mediated Disease Progression in Adenoid Cystic Carcinoma of the Salivary Glands

    Directory of Open Access Journals (Sweden)

    Janyaporn Phuchareon

    2014-10-01

    Full Text Available Adenoid cystic carcinoma (ACC is an aggressive malignant neoplasm of the salivary glands in which c-Kit is overexpressed and activated, although the mechanism for this is as yet unclear. We analyzed 27 sporadic ACC tumor specimens to examine the biologic and clinical significance of c-Kit activation. Mutational analysis revealed expression of wild-type c-Kit in all, eliminating gene mutation as a cause of activation. Because stem cell factor (SCF is c-Kit's sole ligand, we analyzed its expression in the tumor cells and their environment. Immunohistochemistry revealed its presence in c-Kit–positive tumor cells, suggesting an activation of autocrine signaling. We observed a significant induction of ERK1/2 in the cells. SCF staining was also found in other types of non-cancerous cells adjacent to tumors within salivary glands, including stromal fibroblasts, neutrophils, peripheral nerve, skeletal muscle, vascular endothelial cells, mucous acinar cells, and intercalated ducts. Quantitative PCR showed that the top quartile of c-Kit mRNA expression distinguished ACCs from normal salivary tissues and was cross-correlated with short-term poor prognosis. Expression levels of SCF and c-Kit were highly correlated in the cases with perineural invasion. These observations suggest that c-Kit is potentially activated by receptor dimerization upon stimulation by SCF in ACC, and that the highest quartile of c-Kit mRNA expression could be a predictor of poor prognosis. Our findings may support an avenue for c-Kit-targeted therapy to improve disease control in ACC patients harboring the top quartile of c-Kit mRNA expression.

  7. The T-box transcription factor Brachyury regulates epithelial–mesenchymal transition in association with cancer stem-like cells in adenoid cystic carcinoma cells

    Directory of Open Access Journals (Sweden)

    Shimoda Miyuki

    2012-08-01

    Full Text Available Abstract Background The high frequencies of recurrence and distant metastasis of adenoid cystic carcinoma (AdCC emphasize the need to better understand the biological factors associated with these outcomes. To analyze the mechanisms of AdCC metastasis, we established the green fluorescence protein (GFP-transfected subline ACCS-GFP from the AdCC parental cell line and the metastatic ACCS-M GFP line from an in vivo metastasis model. Methods Using these cell lines, we investigated the involvement of the epithelial–mesenchymal transition (EMT and cancer stem cell (CSCs in AdCC metastasis by real-time RT-PCR for EMT related genes and stem cell markers. Characteristics of CSCs were also analyzed by sphere-forming ability and tumorigenicity. Short hairpin RNA (shRNA silencing of target gene was also performed. Results ACCS-M GFP demonstrated characteristics of EMT and additionally displayed sphere-forming ability and high expression of EMT-related genes (Snail, Twist1, Twist2, Slug, zinc finger E-box binding homeobox 1 and 2 [Zeb1 and Zeb2], glycogen synthase kinase 3 beta [Gsk3? and transforming growth factor beta 2 [Tgf-?2], stem cell markers (Nodal, Lefty, Oct-4, Pax6, Rex1, and Nanog, and differentiation markers (sex determining region Y [Sox2], Brachyury, and alpha fetoprotein [Afp]. These observations suggest that ACCS-M GFP shows the characteristics of CSCs and CSCs may be involved in the EMT of AdCC. Surprisingly, shRNA silencing of the T-box transcription factor Brachyury (also a differentiation marker resulted in downregulation of the EMT and stem cell markers. In addition, sphere-forming ability, EMT characteristics, and tumorigenicity were simultaneously lost. Brachyury expression in clinical samples of AdCC was extremely high and closely related to EMT. This finding suggests that regulation of EMT by Brachyury in clinical AdCC may parallel that observed in vitro in this study. Conclusions The use of a single cell line is a limitation of this study. However, parallel data from in vitro and clinical samples suggest the possibility that EMT is directly linked to CSCs and that Brachyury is a regulator of EMT and CSCs.

  8. Carcinoma adenoescamoso do colo uterino mimetizando carcinoma adenóide basal: relato de um caso e revisão da literatura / Adenosquamous carcinoma of the cervix mimicking adenoid basal carcinoma: case report and review of the literature

    Scientific Electronic Library Online (English)

    Álvaro Piazzeta, Pinto; Luiz Roberto, Maia.

    2007-02-01

    Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese O carcinoma adenoescamoso do colo uterino é definido como um tumor que contém uma mistura de células malignas com diferenciação escamosa e glandular. A literatura salienta a importância de se fazer esse diagnóstico, uma vez que, quando os componentes não são bem diferenciados ou não se encontram evi [...] dentes na amostra analisada, esse tumor pode ser erroneamente interpretado como carcinoma escamoso ou adenocarcinoma. O presente trabalho descreve a apresentação pouco comum de um carcinoma adenoescamoso. Após sucessivos diagnósticos citológicos não concordantes e complicados por uma história de sangramento uterino anormal ocasionado por endometriose cervical, a paciente de 47 anos foi submetida a histerectomia total, obtendo diagnóstico definitivo. Esse particular tumor aqui relatado foi diagnosticado como carcinoma adenoescamoso, mas em muitos aspectos apresentou-se semelhante ao carcinoma adenóide basal. Elementos característicos do carcinoma adenóide basal, como presença de lesão intra-epitelial escamosa na superfície, diferenciação escamosa e glandular no centro dos blocos neoplásicos e células basalóides na profundidade da lesão, foram observados em nosso caso. Em contrapartida, os seguintes elementos normalmente não observados no carcinoma adenóide basal estavam presentes: atipias e figuras de mitose nas células indiferenciadas da profundidade do tumor e lesão intra-epitelial escamomucinosa (SMILE) na superfície. Fatores epidemiológicos e clínicos, como idade (47), raça (branca) e forma de apresentação clínica (massa visível na inspeção cervical), também colaboraram para afastar esse diagnóstico diferencial. Outros diagnósticos diferenciais do carcinoma adenoescamoso do colo uterino incluem o carcinoma puramente escamoso ou glandular, o tumor de colisão e o adenocarcinoma de endométrio com diferenciação escamosa invadindo o colo uterino. Abstract in english Adenosquamous carcinoma of the uterine cervix is defined as a tumor that contains a mixture of malignant cells with squamous and glandular differentiation. The literature points to the importance of making this diagnosis when the cellular components are still well differentiated in the sample, other [...] wise the tumor may be erroneously interpreted as squamous carcinoma or adenocarcinoma. This study describes an unusual presentation of a adenosquamous carcinoma in a 47 year old patient. After conflicting cytological diagnoses and a history of abnormal uterine bleeding caused by cervical endometriosis, the patient was subjected to radical hysterectomy and a final diagnosis was obtained. The tumor was diagnosed as adenosquamous carcinoma. In many aspects, however, it was similar to the adenoid basal carcinoma. Characteristic features of the adenoid basal carcinoma such as the presence of high-grade squamous intraepithelial lesion in the surface epithelium, squamous and glandular differentiation in the center of the neoplastic mass, and basaloid cells in deep areas of the tumor were observed. Therefore, the following elements usually absent from adenoid basal carcinoma were present in this case: atypia and mitotic figures in undifferentiated cells, squamous-mucinous intraepithelial lesion (SMILE) in the superficial areas. Epidemiological and clinical data, such as patient age (47), race (white) and presentation (a cervical mass), concurred to exclude the diagnosis of adenoid basal carcinoma. Other differential diagnoses include pure squamous carcinoma or adenocarcinoma, collision tumor, and endometrial adenocarcinoma with squamous differentiation invading the uterine cervix.

  9. Thomsen-Friedenreich (T) antigen as marker of myoepithelial and basal cells in the parotid gland, pleomorphic adenomas and adenoid cystic carcinomas. An immunohistological comparison between T and sialosyl-T antigens, alpha-smooth muscle actin and cytokeratin 14

    DEFF Research Database (Denmark)

    Therkildsen, M H; Mandel, U

    1995-01-01

    Controversy centres on the role and identification of myoepithelial (MEC) and basal cells in salivary gland tumours, and recent studies suggest that both basal cells and myoepithelial cells participate in the formation of salivary gland tumours. We have correlated the expression of different well-known markers of normal MEC/basal cells (i.e. alpha-smooth muscle actin and cytokeratin 14) with T (Thomsen-Friedenreich) antigen and its sialylated derivative: sialosyl-T antigen,) in 17 normal parotid glands and in two tumour types with MEC participation (i.e pleomorphic adenomas (PA) and adenoid cystic carcinomas (ACC)) using immunohistology with well-defined monoclonal antibodies (MAbs). Paraffin-embedded/fresh frozen tissue sections were studied from 33/17 patients with PA and 15/7 patients with ACC. In normal parotid tissue coexpression of alpha-smooth muscle actin, cytokeratin 14, T and sialosyl-T antigens was found in all MEC and in some of the basal cells lining striated ducts. The remaining basal cells exclusively expressed cytokeratin 14, T and sialosyl-T antigens. In the tumours, cells believed to be modified myoepithelial cells showed two different staining patterns: 1) Coexpression of alpha-smooth muscle actin, cytokeratin 14, T and sialosyl-T antigens, and 2) Coexpression of cytokeratin 14, T and sialosyl-T antigens, but no alpha-smooth muscle actin. The epithelial ductular structures in the tumours showed aberrant expression of cytokeratin 14, T and sialosyl-T antigens, and cytokeratin 14 was the only marker of cells in solid undifferentiated areas of adenoid cystic carcinomas. Our study supports the view, that modified "myoepithelial" cells in the tumours consist of a mixture of basal cells and myoepithelial cells. None of the investigated structures was in itself an ideal marker in the identification of MEC/basal cells. The cells can be identified by a combination of markers (i.e. cytokeratin 14, alpha-smooth-muscle actin, T and sialosyl-T antigens).

  10. Inverse planned stereotactic intensity modulated radiotherapy (IMRT in the treatment of incompletely and completely resected adenoid cystic carcinomas of the head and neck: initial clinical results and toxicity of treatment

    Directory of Open Access Journals (Sweden)

    Jensen A

    2006-06-01

    Full Text Available Abstract Background Presenting the initial clinical results in the treatment of complex shaped adenoid cystic carcinomas (ACC of the head and neck region by inverse planned stereotactic IMRT. Materials 25 patients with huge ACC in different areas of the head and neck were treated. At the time of radiotherapy two patients already suffered from distant metastases. A complete resection of the tumor was possible in only 4 patients. The remaining patients were incompletely resected (R2: 20; R1: 1. 21 patients received an integrated boost IMRT (IBRT, which allow the use of different single doses for different target volumes in one fraction. All patients were treated after inverse treatment planning and stereotactic target point localization. Results The mean folllow-up was 22.8 months (91 – 1490 days. According to Kaplan Meier the three year overall survival rate was 72%. 4 patients died caused by a systemic progression of the disease. The three-year recurrence free survival was according to Kaplan Meier in this group of patients 38%. 3 patients developed an in-field recurrence and 3 patient showed a metastasis in an adjacent lymph node of the head and neck region. One patient with an in-field recurrence and a patient with the lymph node recurrence could be re-treated by radiotherapy. Both patients are now controlled. Acute side effects >Grade II did only appear so far in a small number of patients. Conclusion The inverse planned stereotactic IMRT is feasible in the treatment of ACC. By using IMRT, high control rates and low side effects could by achieved. Further evaluation concerning the long term follow-up is needed. Due to the technical advantage of IMRT this treatment modality should be used if a particle therapy is not available.

  11. Bacteremia during adenoidectomy: a comparison of suction diathermy adenoid ablation and adenoid curettage.

    LENUS (Irish Health Repository)

    Casserly, Paula

    2010-08-01

    Transient bacteremia is induced by adenoidectomy when the integrity of the nasopharyngeal membrane is broken. The aim of this study was to determine the incidence of bacteremia in patients undergoing adenoidectomy, to identify the causative organisms, and to compare the incidences of bacteremia between the two techniques suction diathermy and curettage.

  12. Small bowel obstruction caused by peritoneal immunoglobulin G4-related disease mimicking carcinomators: Case report

    Energy Technology Data Exchange (ETDEWEB)

    Coulier, Bruno; Montfort, Luc; Pierard, Frederic [Clinique St. Luc, Bouge (Belgium); Beniuga, Gabrique; Gielen, Lsabelle [Institute of Pathology and Genetics, Gosselies (Belgium)

    2014-02-15

    We hereby report a case of diffuse pelvic peritoneal involvement by immunoglobulin G4-related disease (IgG4-RD). Numerous pelvic masses and nodules showing delayed enhancement on enhanced abdominal CT were found to congregate in the pelvic organs of a 57-year-old female presenting with intestinal subocclusion. The differentiation between peritoneal IgG4-RD and pelvic peritoneal carcinomatosis was only made by histopathology and immunohistochemistry performed after surgical resection. Autoimmune pancreatitis represents the historical prototype of IgG4-RD, but the spectrum of manifestations involving various organs has expanded during the last decade. In this report, we shortly review this clinical entity.

  13. Small bowel obstruction caused by peritoneal immunoglobulin G4-related disease mimicking carcinomators: Case report

    International Nuclear Information System (INIS)

    We hereby report a case of diffuse pelvic peritoneal involvement by immunoglobulin G4-related disease (IgG4-RD). Numerous pelvic masses and nodules showing delayed enhancement on enhanced abdominal CT were found to congregate in the pelvic organs of a 57-year-old female presenting with intestinal subocclusion. The differentiation between peritoneal IgG4-RD and pelvic peritoneal carcinomatosis was only made by histopathology and immunohistochemistry performed after surgical resection. Autoimmune pancreatitis represents the historical prototype of IgG4-RD, but the spectrum of manifestations involving various organs has expanded during the last decade. In this report, we shortly review this clinical entity.

  14. Le carcinome rectal: nécessité de la radiothérapie dans l'élaboration du plan thérapeutique.

    OpenAIRE

    Coucke, Philippe; Bosset, J-f; Mirimanoff, R-o

    1991-01-01

    Postoperative radiotherapy is highly effective in the prevention of local recurrence in rectal cancer. Nevertheless, the results remain disappointing for Locally Advanced Rectal Cancer. New approaches include introduction of chemotherapy to postoperative radiotherapy or combined radiotherapeutic treatment with preoperative irradiation, surgery and intraoperative irradiation, along with elective postoperative treatment in function of surgical and pathological data. Based on recent advances in ...

  15. Traitement des carcinomes du larynx par radiothérapie radicales avec ou sans chimiothérapie: résultats et facteurs pronostiques

    OpenAIRE

    Shehata, Emad

    2009-01-01

    Le but de cette étude est d'examiner l'impact de l'envahissement des différents sous-sites du larynx sur les résultats oncologiques lors du traitement de cancers laryngés avec la radiothérapie ± chimiothérapie. Pour cela, une étude rétrospective de patients consécutifs traités aux HUG entre 1996-2005 par cette modalité a été entreprise. Nos résultats montrent que les stades T avancés, une atteinte de la commissure antérieure et de la sous-glotte sont associés à une survie e...

  16. Skeleton scintigraphy and radiologic data at 403 patients with prostata carcinom

    International Nuclear Information System (INIS)

    In a retrospective study 403 patients with prostatic carcinoma (PC) were examined to shed light on the relation between the rate of metastases and the stage of local tumor spread as well as the histomorphologic tumor type; to establish the rate of metastases detected by bone scanning versus radiology; and to compare the contributions of bone scanning versus radiology in monitoring the response of bone metastases to treatment. Results: (1) The rate of metastases was found to increase as a function of primary tumor size and increasing dedifferentiation; however, bone metastases were also seen in highly differentiated stage O and A PC. (2) Solitary metastases were confined to the pelvic bones and lumbar vertebrae. (3) About one third of all bone metastases were radiologically silent; in sporadic cases receiving contrasexual therapy they remained silent for more than 5 years. (4) Bone scnaning showed 73.3% of patients to respond to contrasexual therapy and 26.7% to be non- responders. (6) There were some differences or even discrepancies between bone scans and radiology in documenting the results of treatment. Conclusions: Repeated bone scans are required for monitoring the course of the disease even if the primary tumor is extremely small and histologically well differentiated. Bone scans are superior to radiology in detecting metastases. While repeat X-rays during the course of a disease furnish important information, they are unsuited for monitoring the response to trensuited for monitoring the response to treatment. (Author)

  17. Irradiation of low rectal cancers; Radiotherapie des carcinomes du bas rectum

    Energy Technology Data Exchange (ETDEWEB)

    Ardiet, J.M.; Coquard, R.; Romestaing, P.; Fric, D.; Baron, M.H.; Rocher, F.P.; Sentenac, I.; Gerard, J.P. [Centre Hospitalier Lyon-Sud, 69 -Pierre-Benite (France)

    1994-12-31

    The low rectal cancers are treated by anorectal amputation and pose the problem of the sphincter conservation. Some authors extend the clinical definition to developed injuries until 12 cm from the anal margin. The rectal cancer is a frequent tumour which remains serious. When the tumour is low, the treatment consists in an anorectal amputation with a permanent colostomy. The radical non preserving surgery is the usual treatment of these injuries. Until 1960 the rectal adenocarcinoma was considered as a radioresistant tumour because of the impossibility to deliver an enough dose to the tumour by external radiotherapy. But other studies showed that those lesions were radiosensitive and often radiocurable. The medical treatments haven`t yet demonstrated their efficiency in the treatment of the rectal cancer. We`ll study the radiotherapy in the treatment of the low rectal cancer, solely radiotherapy, radiosurgical associations. 32 refs., 5 tabs.

  18. Late neurotoxicity after nasopharyngeal carcinoma treatment;Toxicite neurologique tardive apres traitement des carcinomes nasopharynges

    Energy Technology Data Exchange (ETDEWEB)

    Siala, W.; Mnejja, W.; Daoud, J. [Hopital Habib-Bourguiba, Service de Radiotherapie Carcinologique, Sfax (Tunisia); Khabir, A.; Boudawara, T. [Hopital Habib-Bourguiba, Service d' Anatomopathologie, Sfax (Tunisia); Ben Mahfoudh, K. [Hopital Habib-Bourguiba, Service de Radiologie, Sfax (Tunisia); Ghorbel, A. [Hopital Habib-Bourguiba, Service d' ORL, Sfax (Tunisia); Frikha, M. [Hopital Habib-Bourguiba, Service de Carcinologie Medicale, Sfax (Tunisia)

    2009-12-15

    Purpose A retrospective analysis of risk factors for late neurological toxicity after nasopharyngeal carcinoma radiotherapy. Patients and methods Between 1993 and 2004, 239 patients with non metastatic nasopharyngeal carcinoma were treated by radiotherapy associated or not to chemotherapy. Radiotherapy was delivered with two modalities: hyperfractionated for 82 patients and conventional fractionation for 157 patients. We evaluated the impact of tumour stage, age, gender, radiotherapy schedule and chemotherapy on neurological toxicity. Results After a mean follow-up of 107 months (35-176 months), 21 patients (8.8%) developed neurological complications, such as temporal necrosis in nine cases, brain stem necrosis in five cases, optics nerve atrophy in two cases and myelitis in one case. Five- and ten-year free of toxicity survival was 95 and 84% respectively. Young patients had greater risk of temporal necrosis, and hyperfractionated radiotherapy was associated with a significantly higher risk of neurological complications (14.6% vs 5.7%, p = 0.02). On multivariate analysis, hyperfractionation and age were insignificant. Conclusion Late neurological toxicity after radiotherapy for nasopharyngeal carcinoma was rare. Younger age and hyperfractionation were considered as risk factors of neurological toxicity in our study

  19. Sorafenib and radiotherapy association for hepatocellular carcinoma; Sorafenib et radiotherapie dans le carcinome hepatocellulaire

    Energy Technology Data Exchange (ETDEWEB)

    Girard, N. [Service de pneumologie, hopital Louis-Pradel, hospices Civils de Lyon, 28, avenue du Doyen-Jean-Lepine, 69500 Bron (France); UMR 754, universite Claude-Bernard Lyon 1, 43, boulevard du 11-novembre-1918, 69622 Villeurbanne cedex (France); Mornex, F. [UMR 754, universite Claude-Bernard Lyon 1, 43, boulevard du 11-novembre-1918, 69622 Villeurbanne cedex (France); Departement de radiotherapie-oncologie, centre hospitalier Lyon Sud, 165, chemin du Grand-Revoyet, 69495 Pierre-Benite cedex (France)

    2011-02-15

    Conformal radiotherapy is a promising therapeutic strategy for hepatocellular carcinoma (HCC), producing local control rates above 90% within the radiation beam. However, survival after radiotherapy remains limited by the high frequency of intra- and extra-hepatic recurrences, which occurs in 40-50 and 20-30% of cases, respectively. Sorafenib (BAY43-9006, Nexavar; Bayer, West Haven, CT) is a small molecule inhibitor that demonstrated potent activity to target v-raf murine sarcoma oncogene homologue B1 (BRAF) and VEGFR tyrosine kinases. Sorafenib is the only drug that demonstrated effectiveness to increase overall survival in advanced or metastatic hepatocellular carcinoma. The rationale to combine radiotherapy with sorafenib is the following: (1) targeting RAS-RAF-MAPK and VEGFR signaling pathways, which are specifically activated after exposure to radiation, and responsible for radio-resistance phenomenon; (2) enhancing the oxygen effect through normalization of the surviving tumor vasculature; and (3) synchronization of the cell cycle. Sorafenib and radiotherapy represent complementary strategies, as radiotherapy may be useful to prolong the effect of sorafenib through control of the macroscopic disease, when sorafenib may target latent microscopic disease. Sorafenib and radiotherapy associations are thus based on a relevant biological and clinical rationale and are being evaluated in ongoing phase I-II trials. (authors)

  20. Studies on therapeutic method of liver cancer(hapatocellular carcinome)by Holmium-166 radionuclide

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Jong Tae; Yoo, H. S.; Kim, M. J.; Han, K. H.; Park, C. I. [Yonsei University Medical College, Seoul (Korea, Republic of)

    1997-07-01

    As the study of radioactive nuclide, Holmium-166 in the treatment of liver cancer(hepatocellular carcinoma), this study was performed under the base of animal experimental. Using dog liver, percutaneous injection of Ho-166 MAA or chitosan with premade dose was done under the ultrasound guidance. Continuously the same procedure as previous one was performed in the skin hapatoma, which was developed by the injection of hepatocellular carcinoma cell in the nude mouse, In case of injected normal liver of dog, imaging study including ultrasound, CT and MRI was done in order to evaluate effect of Ho-166 and pathologic reaction. The result showed well defined nectosis of normal liver as well as skin hepatoma. The area of nectosis is dependent on the dose of injected Ho-166. Generally, pathologic reaction is tissue coagulation nectosis, Ho-166 particles, fibrosis and hemorrhage. In the clinical study, 50 patients with hapatoma was selected for this study under the agreement of patient. Under ultrasound guidance percutaneous injection of Ho-166 Maa or chitosan to tumor was performed and follow-up study was extended from 6 to 12 month. The result showed that 64% of patient were completely treated. Overall, the effect of treatment could be obtained in 41 patient (82%) among 50 hepatoma patient. Conclusively Ho-166 is thought to be a compromising agent in the treatment of hepatocellular carcinoma and one of therapeutic modality, if it is established internally and world-wide. In the future, the popular percutaneous ethanol injection method will be replaced to this method. 19 refs., 1 tabs., 14 figs. (author)

  1. Nasopharyngeal carcinomas: from biology to clinic; Les carcinomes du nasopharynx: de la biologie a la clinique

    Energy Technology Data Exchange (ETDEWEB)

    Rivera, S.; Maingon, P. [Centre Georges-Francois-Leclerc, Dept. de Radiotherapie, 21 - Dijon (France); Keryer, C.; Busson, P. [Institut Gustave-Roussy, CNRS/UMR 8126, 94 - Villejuif (France)

    2005-02-15

    Nasopharyngeal carcinomas (NPC) are very different from other head and neck cancers because of their specific multi-factorial etiology and their geographic distribution. Epstein-Barr Virus (EBV) is implicated in onco-genesis of NPC in association with genetic alterations such as inactivation of the p16/Ink4, p19/ARF, RASSFI or Blu genes. Tumoral tissues include a very abundant characteristic lymphoid infiltrate. Inflammatory cytokines are produced by both malignant and infiltrating cells. There is no efficient immune response against the tumor. On the opposite, infiltrating lymphocytes might play a role in tumor development. Serological methods and detection of circulating viral DNA are expected to become useful for early detection of relapse and on a longer term for primary screening. NPC are often diagnosed at a late stage because patients may remain asymptomatic for a long time. Computed tomography (CT scan) and magnetic resonance imaging (MRI) are complementary for the initial evaluation. Positron emission tomography (PET) is efficient for the evaluation of treatment efficiency and detection of relapses. Treatment is based on radiotherapy and chemotherapy. Their optimal use needs to be evaluated by phase III trials but positive results have been obtained by concomitant association of radiotherapy and chemotherapy. Targeted therapies are being studied with strategies based on disruption of viral latency, use of replicative adeno-viruses or anti-tumor vaccination. (author)

  2. The expression of aquaporin 1 in renal cell carcinomal before and after interventional treatment and its significance

    International Nuclear Information System (INIS)

    Objective: To evaluate the effect of interventional treatment on the expression level and distribution of aquaporin 1 (AQP1) in renal cell carcinoma and its significance. Methods: Fifteen cases of renal cell carcinoma tissues which received chemotherapy embolism before nephrectomy and 12 cases of renal cell carcinoma tissues which only had nephrectomy were studied as test group. Twelve cases of normal kidney tissues were studied as control groups. RT-PCR, western blot analysis and immunohistochemical method were performed to detect the expression of AQP1 on different tissues. Results: In normal kidney tissues, AQP1 expressed in the capillary endothelia cells of glomerulus, epithelial cell of proximal tubules. In renal cell carcinoma tissues, AQP1 expressed in tumor cells and epithelial cells of capillary vessel. Expression of AQP1 remarkably decreased in renal cell carcinoma tissues compared with normal kidney tissues (Pixel intensity rate of AQP1 and ?-actin by RT-PCR methods were 0.935 and 0.855 respectively; AQP1 positive pixel intensity by western blot methods were 125.8 and 147.4 respectively; positive index of AQP1 pixel intensity by immunohistochemical method were 1.31 and 1.08, P<0.01). Expression of AQP1 remarkably decreased in renal cell carcinoma tissues which received chemotherapy embolism compared with renal cell carcinoma which only had nephrectomy (Pixel intensity rate of AQP1 and ?-actin by RT-PCR methods was 0.810; AQP1 positive pixel intensity by w.810; AQP1 positive pixel intensity by western blot methods was 159.7; positive index of AQP1 pixel intensity by immunohistochemical method was 0.82, P<0.05). Conclusion: Interventional treatment can depress the expression of AQP1 in renal cell carcinoma and suppress the growth and metastasis of renal cell carcinoma. (authors)

  3. Reirradiation by Cyberknife of head and neck carcinomas; Reirradiation par Cyberknife de carcinomes de la tete et du cou

    Energy Technology Data Exchange (ETDEWEB)

    Balajouza Kanoun, S.; Lacornirie, T.; Coche Dequeant, B.; Mirabel, X.; Lefebvre, J.L.; Lartigau, E. [Centre Oscar-Lambret, Univ. de Lille-2, Dept. Universitaire de Radiotherapie, 59 - Lille (France)

    2007-11-15

    In spite of local treatment the local defeat is a problem in O.R.L. cancerology. It has been demonstrated that some recurrences or second cancers in beforehand irradiated area could be sterilized by a new irradiation of high dose after perfect definition of the volume to treat and the certainty that recurrence will be localized.Numerous works have allowed to underline that a part of patients, with an O.R.L. recurrence can be treated again with curative aim with survival rate about 20 to 20 % at three years. The objective of this study was to test with a phase two study, the validation of a stereotaxic type reirradiation by Cyberknife associated to Cetuximab. (N.C.)

  4. Primitive epidermoid breast carcinoma. About 13 cases; Carcinome epidermoide primitif du sein. A propos de 13 cas

    Energy Technology Data Exchange (ETDEWEB)

    Masbah, O.; Kebdani, T.; Bouhafa, O.; Bekkouch, I.; Mellas, N.; Kanouni, L.; Hassouni, K.; Benjaafar, N.; El Gueddari, B.K. [Service de Radiotherapie, Rabat (Morocco)

    2009-10-15

    Purpose: to enhance the epidemiological, clinical, histologic, therapeutic, prognostic and progressive characteristics of primitive squamous cell carcinomas of the breast. Conclusion: The primitive pure squamous cell carcinomas of the breast are rare. The clinic and radiological aspects are not specific. The treatment stands on the surgery with axillary lymph node dissection. The adjuvant treatment associates radiotherapy and chemotherapy, which type is still to precise, hormones therapy is recommended in the rare cases where the hormone receptors are expressed. Their prognosis is in general unfavourable. (N.C.)

  5. Place of radiotherapy in tonsil carcinomas; Place de la radiotherapie dans les carcinomes de l`amygdale

    Energy Technology Data Exchange (ETDEWEB)

    Sahraoui, S.; Acharki, A.; Samlali, R.; Benider, A.; Kahlain, A.

    1995-12-31

    Oropharynx carcinomas are generally located at the level of palatine tonsil and are characterized by a great frequency of locally advanced steps. The radiotherapy keeps an important place in therapy. This has been demonstrated for a long time because the only surgery, maiming, could not be used in wide localizations. In fact, after the experience of 110 cases, exposed here, and with the comparison of others authors, it is concluded that radiotherapy must be used in first intention, surgery coming after it, only in compensation. (N.C.). 13 refs., 1 fig., 1 tab.

  6. Invasive cervical carcinoma: methods of investigation, diagnostic strategy; Carcinomes invasifs du col uterin: methodes d`exploration strategie diagnostique

    Energy Technology Data Exchange (ETDEWEB)

    Ternier, F.; Rosello, R.; Stefano-Louineau, D. Di.; Le Brigand, B.; Mouillac, G.; Resbeut, M. [Institut Paoli-Calmettes, 13 - Marseille (France); Kind, M. [Fondation Bergonie, 33 - Bordeaux (France)

    1997-09-01

    The authors review various techniques, including endo-sonography, computed tomography, magnetic resonance imaging and lymphography for the pre therapeutic evaluation of cancer of the uterine cervix, as well as for post therapeutic follow up. The pre-therapeutic examination should evaluate size of the primary tumor and tumor extension to vagina, parametria, bladder, rectum and pelvic sidewall. Pelvic lymph nodes evaluation is assessed by CT, MRI or lymphography. In stage IB, IIA and proximal IIB carcinoma, most patients will be operated and will have an intraoperative lymph node exploration and thus a surgical and clinico-pathological staging will be performed. In this case, clinical staging is often accurate. For larger tumors, radiological exploration will be more thorough for an optimal determination of the tumoral stage. (authors). 72 refs.

  7. Is the adaptive tomography of cervical carcinomas necessary?; La tomotherapie adaptative des carcinomes du col uterin est-elle necessaire?

    Energy Technology Data Exchange (ETDEWEB)

    Le Tinier, F.; Nickers, P.; Reynaert, N.; Castelain, B.; Lacornerie, T.; Attar, M.; Lartigau, E. [Centre Oscar-Lambret, 59 - Lille (France)

    2010-10-15

    The authors report the study of the macroscopic tumour volume (GTV, gross tumour volume) and its possible repercussion on organs at risk during a tomo-therapy with an additional concomitant centro-pelvic irradiation. Ten women with non-operable cervical carcinomas have been treated by tomo-therapy and chemotherapy. A high-energy conical tomography has been performed before each session. Data obtained from these tomographies have been used in the adaptive therapy module of a tomo-therapy planimetry software. It appears that there is no evidence of significant variations of doses at the level of organs at risk with the use of such software. Short communication

  8. Prevalence of Microorganisms and Immunoglobulins in Children with Tonsillar Hypertrophy and Adenoiditis

    Scientific Electronic Library Online (English)

    Henrique Prestes, Miramontes; Djalma José, Fagundes; Julia Coelho Lima e, Jurgielewicz; Haroldo Prestes, Miramontes Neto; Renan Gianotto de, Oliveira; Gustavo Gianotto de, Oliveira; Maria Rosa Machado de, Souza.

    2014-09-01

    Full Text Available Introduction: Benign idiopathic tonsillar hypertrophy (HBI) may affect a child's quality of life and sleep. Several studies have sought to relate the clinical features of HBI with the infectious and/or immunologic changes that occur. Objective: To increase the knowledge of the etiology of HBI. [...] Data Synthesis: From 2012 to 2013 we conducted a retrospective observational study of 101 children with HBI who underwent tonsillectomies at Ambulatory ENT General Hospital of the East Zone of São Paulo City, a region with a poor socioeconomic population. Preoperative serologic results were available to confirm mononucleosis, cytomegalovirus, anti-streptolysin O (ASLO) and immunoglobulins. The mean patient age was 5.8 years (55% male, 45% female). Using the Mann-Whitney U test, we identified significant gender differences in the parameters of immunoglobulins (Ig) M (IgM), IgA, and IgE. Forty-seven percent of the patients had increased ASLO levels, and 37% had increased IgE levels. Conclusion: An evaluation of a patient's serologic parameters and laboratory results may be relevant to the etiology and prevention of HBI. Based on the results obtained from the study sample, the identification of etiologic agents and causative factors remain a public health challenge that affects the quality of life of children.

  9. Carcinoma adenóide cístico: relato de caso = Adenoid cystic carcinoma: case report

    Directory of Open Access Journals (Sweden)

    Palmeiro, Mariana Reuter et al.

    2005-01-01

    Full Text Available O carcinoma adenóide cístico é uma neoplasia maligna rara de crescimento lento, caracterizado prognóstico reservado, devido a sua agressividade e grande potencial recidivante. A lesão é mais prevalente em pacientes na faixa etária entre 50 e 70 anos, sendo incomum em jovens. O artigo relata um caso de carcinoma adenóide cístico de glândulas salivares menores localizado no palato duro em pacientes com 26 ano, do sexo masculino que foi encaminhado para tratamento no Serviço de Cirurgia de Cabeça e Pescoço.

  10. Supra-scapular nerve entrapment by ganglion cyst. Value of imaging modalities; Compression kystique du nerf sus-scapulaire. Interet de l`imagerie. A propos de 6 cas et revue de la litterature

    Energy Technology Data Exchange (ETDEWEB)

    Levy, Ph.; Roger, B.; Tardieu, M.; Ghebontni, L.; Thelen, Ph.; Richard, O.; Grenier, Ph. [Hopital Pitie-Salpetriere, 75 - Paris (France)

    1997-09-01

    Six cases of supra-scapular nerve entrapment by a ganglion cyst within the spino-glenoid notch or developed from the glenoid labrum are reported. Causes of injury or entrapment of the supra-scapular nerve are described including traction or kinking of the nerve, trauma, repetitive exercise, or compression by ganglion cyst. The patients had non specific pain, weakness, and atrophy of the spinatus musculature. Electromyography showed evidence of denervation atrophy. Patients had plain radiographs, arthrography, CT-arthrography, magnetic resonance imaging (MRI) and MR-arthrography. Masses that caused supra-scapular nerve entrapment were well localized and characterized with magnetic resonance imaging, reflecting the superior soft-tissue contrast of this modality. In addition, MRI may demonstrate atrophy of the spinatus muscles. MR-arthrography allows to visualize lesions of the glenoid labrum and in some cases, demonstrates cysts filling. (authors). 35 refs.

  11. Analysis of the economic impact of cystic echinococcosis in Spain / Analyse de l'impact économique de l'échinococcose kystique en Espagne / Análisis del impacto económico de la hidatidosis en España

    Scientific Electronic Library Online (English)

    Christine, Benner; Hélène, Carabin; Luisa P, Sánchez-Serrano; Christine M, Budke; David, Carmena.

    2010-01-01

    Full Text Available SciELO Public Health | Language: English Abstract in spanish OBJETIVO: Estimar las pérdidas económicas totales ocasionadas por la hidatidosis humana y animal en España en 2005. MÉTODOS: Los datos sobre la incidencia anual de la hidatidosis se obtuvieron a partir de los registros de vigilancia epidemiológica y de los mataderos. Los datos sobre el tratamiento y [...] la pérdida de productividad (humana y animal) relacionada con la enfermedad se obtuvieron a partir de la literatura científica. Los costes directos fueron los asociados al diagnóstico, el tratamiento quirúrgico o farmacológico, la atención médica y la hospitalización en humanos, y los decomisos de vísceras infectadas en animales de abasto (ganado ovino, caprino, bovino y porcino). Los costes indirectos comprendieron la pérdida de productividad en humanos y la reducción de las tasas de crecimiento, fecundidad y producción de leche en el ganado. Para representar la incertidumbre asociada a los parámetros analizados se utilizó el método del hipercubo latino. RESULTADOS: Las pérdidas económicas totales atribuibles a la hidatidosis humana y animal fueron estimadas en 148 964 534 euros (€) (intervalo de credibilidad del 95%, IC95%: 21 980 446-394 012 706). Las pérdidas estimadas de origen humano fueron de € 133 416 601 (IC95%: 6 658 738-379 273 434), y de € 15 532 242 (IC95%: 13 447 378-17 789 491) las de origen animal. CONCLUSIÓN: La hidatidosis es una zoonosis desatendida que en España sigue constituyendo un problema de salud humana y animal. Son necesarios datos más exactos sobre la prevalencia de la hidatidosis en humanos (sobre todo en los casos no diagnosticados o asintomáticos) y mejores métodos para calcular la pérdida de productividad en animales. La hidatidosis sigue afectando a ciertas zonas de España pese a las varias campañas de control emprendidas desde 1986. Dada la gran carga económica de la hidatidosis, es necesaria una mayor financiación para reducir las tasas de infección humana y animal mediante mejoras en la vigilancia de la enfermedad, el tratamiento periódico de los perros y la cooperación entre organismos oficiales. Abstract in english OBJECTIVE: To estimate the overall economic losses due to human and animal cystic echinococcosis (CE) in Spain in 2005. METHODS: We obtained data on annual CE incidence from surveillance and abattoir records, and on CE-related treatment and productivity losses (human and animal) from the scientific [...] literature. Direct costs were those associated with diagnosis, surgical or chemotherapeutic treatment, medical care and hospitalization in humans, and condemnation of offal in livestock (sheep, goats, cattle and pigs). Indirect costs comprised human productivity losses and the reduction in growth, fecundity and milk production in livestock. The Latin hypercube method was used to represent the uncertainty surrounding the input parameters. FINDINGS: The overall economic loss attributable to CE in humans and animals in 2005 was estimated at 148 964 534 euros (€) (95% credible interval, CI: 21 980 446-394 012 706). Human-associated losses were estimated at €133 416 601 (95% CI: 6 658 738-379 273 434) and animal-associated losses at €15 532 242 (95% CI: 13 447 378-17 789 491). CONCLUSION: CE is a neglected zoonosis that remains a human and animal health concern for Spain. More accurate data on CE prevalence in humans (particularly undiagnosed or asymptomatic cases) and better methods to estimate productivity losses in animals are needed. CE continues to affect certain areas of Spain, despite several control initiatives since 1986. Given the high economic burden of CE, additional funding is needed to reduce human and animal infection rates through improved disease surveillance, regular treatment of dogs and greater cooperation between agencies.

  12. RADIOTHÉRAPIE MAMMAIRE- pret-à-porter ou sur mesure ?

    OpenAIRE

    Coucke, Philippe; Lakosi, Ferenc

    2014-01-01

    La radiothérapie mammaire après chirurgie conser - vatrice, pour carcinome canalaire in situ ou pour les formes invasives (carcinome canalaire infiltrant et carcinome lobu - laire infiltrant), semble très bien codifiée et peut être taxée de «prêt-à-porter». Et pourtant, on est en droit de se poser la question s’il est possible de concevoir des indications de traitement «sur mesure». A ce jour, les données de la littéra - ture nous incitent ?...

  13. Chemoradiotherapy in head and neck squamous cell carcinoma: focus on targeted therapies; La chimioradiotherapie des carcinomes epidermoides des voies aerodigestives superieures: point sur les therapeutiques ciblees

    Energy Technology Data Exchange (ETDEWEB)

    Bozec, A. [Centre Antoine-Lacassagne, Dept. de Chirurgie, Institut Universitaire de la Face et du Cou, 06 - Nice (France); Thariat, J.; Bensadoun, R.J. [Centre Antoine-Lacassagne, Dept. de Radiotherapie, Institut Universitaire de la Face et du Cou, 06 - Nice (France); Milano, G. [Centre Antoine-Lacassagne, Unite d' Oncopharmacologie, Institut Universitaire de la Face et du Cou, 06 - Nice (France)

    2008-01-15

    Radiotherapy is an essential treatment for many patients with head and neck squamous cell carcinoma. Its association with molecular targeted therapies represents a real progress. Among the recent advances in the molecular targeted therapy of cancer, the applications centred on E.G.F.R. are currently the most promising and the most advanced at clinical level. Considering the set of therapeutic tools targeting E.G.F.R., there are at present two well-identified emerging categories of drugs with monoclonal antibodies, on the one hand, and tyrosine kinase inhibitors, on the other. In many preclinical studies, the combination of anti-E.G.F.R. drugs with irradiation has led to additive or supra-additive cytotoxic effects. Furthermore, anti-angiogenic agents have shown promising results in association with anti-E.G.F.R. drugs and radiotherapy. This research effort has recently produced encouraging clinical results in advanced head and neck cancer with combination of cetuximab (an anti-E.G.F.R. monoclonal antibody) with irradiation with a significant impact on patient survival. Active and efficient clinical research is currently ongoing to determine the place of molecular targeted therapies in the treatment of head and neck cancer, particularly in association with radiotherapy. (authors)

  14. Inoperable metastatic giant basal cell trunk carcinoma: radiotherapy can be useful; Carcinome basocellulaire geant du tronc metastatique inoperable: la radiotherapie peut etre utile

    Energy Technology Data Exchange (ETDEWEB)

    Mania, A.; Durando, X.; Lapeyre, M. [Centre Jean-Perrin, Clermont-Ferrand (France); Barthelemy, I. [CHU Estaing, Clermont-Ferrand (France)

    2011-10-15

    The authors evoke some characteristics of the basal cell carcinoma (slow evolution, local morbidity) and report and discuss the case of a giant basal cell trunk carcinoma, associated with several symptoms (pain, bleeding, anaemia), already metastatic at the moment of diagnosis, and locally treated by irradiation. Due to its size and expansion, this carcinoma was considered as inoperable. An external radiotherapy has been performed and resulted in a significant clinical tumour reduction. But the metastatic risk is high in such cases. Radiotherapy is then a therapeutic option for a local treatment with a durable efficiency. Short communication

  15. Concomitant chemoradiotherapy in the treatment of the locally evolved larynx carcinoma; Chimioradiotherapie concomitante dans le traitement du carcinome du larynx localement evolue

    Energy Technology Data Exchange (ETDEWEB)

    Houjami, M.; Tarkouki, K.; Benjelloun, H.; Benchakroun, N.; Jouhadi, H.; Tawfiq, N.; Sahraoui, S.; Benider, A. [Centre d' Oncologie Ibn-Rochd, Casablanca (Morocco)

    2007-11-15

    The objective of this was to evaluate the contribution of concomitant chemoradiotherapy in the treatment of locally evolved larynx carcinomas. The results of the series are comparable to these ones got by several studies. The concomitant chemoradiotherapy tends to give a good local control with the advantage of organ conservation, at the price of an acceptable toxicity.The improvement of larynx cancer prognostic is through an early diagnosis but the fight against smoking constitutes the only means of prevention. (N.C.)

  16. Choanal stenosis: a rare complication of radiotherapy for nasopharyngeal carcinoma; Stenose choanale post-radique: une complication rare de la radiotherapie des carcinomes nasopharynges

    Energy Technology Data Exchange (ETDEWEB)

    Bonfils, P.; Preobrajenski, N. de [Universite Rene-Descartes, Hopital Europeen Georges-Pompidou, Service d' ORL et de Chirurgie Cervicofaciale, Faculte de Medecine Paris-Descartes, 75 - Paris (France); Florent, A. [Cabinet d' ORL, 75 - Paris (France); Bensimon, J.L. [Cabinet de radiologie, 75 - Paris (France)

    2007-05-15

    Choanal stenosis is usually a congenital anomaly in children. Acquired choanal stenosis after radiotherapy for nasopharyngeal carcinoma is a very rare pathology; only two publications report seven cases in the literature. We describe the clinical history, preoperative evaluation, surgical treatment and outcome of a case of acquired choanal stenosis after radiotherapy. The patient, a 56-year-old woman, presented with a history of nasopharyngeal carcinoma (T2- NO-MO) one year before that had been successful treated with radiotherapy (68 Gy). At the end of radiotherapy, she complained of complete nasal obstruction, anosmia and hearing loss due to a bilateral serous otitis media. Bilateral complete choanal stenosis was confirmed by endoscopy and CT scan. Functional endoscopic surgery was performed, and nasal stents were left in place for 3 weeks. One year after, the patient have good airflow, and a patent nasopharynx without choanal stenosis. In conclusion, choanal stenosis is an unusual complication of radiotherapy that can be successfully treated with trans-nasal endoscopic resection. (authors)

  17. Pseudo-angiomatous liver metastasis of thyroid medullary carcinoma: multimodality diagnostic approach; Metastase hepatique pseudoangiomateuse d'un carcinome medullaire de la thyroide: approche diagnostique multimodalite

    Energy Technology Data Exchange (ETDEWEB)

    Imperiale, A.; Keomany, J.; Rust, E.; Constantinesco, A. [CHU de Strasbourg, Service de biophysique et medecine nucleaire, 67 (France); Greget, M. [CHU de Strasbourg, Service de radiologie 1, 67 (France); Chabrier, G.; Goichot, B. [CHU de Strasbourg, Service de medecine interne, endocrinologie et nutrition, 67 (France); Detour, J. [CHU de Strasbourg, Service de radiopharmacie, 67 (France); Pessaux, P. [CHU de Strasbourg, Service de chirurgie generale, hepatique et endocrinienne, 67 (France)

    2010-07-01

    Purpose: Illustrate the result of the diagnosis by multimodality imaging (MRI, scintigraphy {sup 123}I-Mibg, PET/CT{sup 18}F-F.D.G. and {sup 18}F-F DOPA) with liver metastasis looking like a single angioma in a patient with atypical medullary thyroid carcinoma. Conclusions: Angiomas must be taken into account in the differential diagnosis of liver metastasis of endocrine tumors, particularly in the case of small injuries where it may be difficult to differentiate a peripheral nodular contrast enhancement of a globular enhancement characteristics of angiomas. (N.C.)

  18. Contribution of radiotherapy in the treatment of cavum carcinomas at Yaounde; Apport de la radiotherapie dans le traitement des carcinomes du cavum a Yaounde

    Energy Technology Data Exchange (ETDEWEB)

    Yomi, J.; Fouda, A.; Maloum, E.; Bengono, G.

    1995-12-31

    A lot of works show that cavum carcinomas make of Cameroon an area at intermediary risks non negligible. The radiotherapy seems to be the only efficient technique but it is still non well known in our hospitals. This works wants to plaid in favor of its acknowledge and its optimal use by showing its contribution and its application difficulties. 5 refs., 1 tab.

  19. Fast neutron therapy of bronchus carcinoma: the pooled results from two european centres; Utilisation de neutrons rapides dans le traitement des carcinomes bronchiques. Experience de deux centres europeens

    Energy Technology Data Exchange (ETDEWEB)

    Lessel, A. [Humboldt-Universitaet, Berlin (Germany)

    1996-12-31

    The Berlin-Buch and Heidelberg centres used fast neutron therapy in bronchial carcinomas. The neutron source was a cyclotron in Berlin-Buch/Rossendorf and a d-t generator in Heidelberg. Three hundred twelve patients with inoperable bronchial carcinoma were treated with fast neutron therapy alone or in combination with photons. The results were then compared with those obtained from 594 patients treated only with photons. Altogether, 788 were treated in Berlin-Buch and 188 in Heidelberg. The results suggest that neutron therapy for bronchial carcinoma can be a good alternative in curative and palliative situations in the early stages. (author). 14 refs.

  20. Trans-arterial chemo-embolization and conformal radiotherapy for hepatocellular carcinoma; Chimioembolisation et radiotherapie de conformation dans le traitement du carcinome hepatocellulaire

    Energy Technology Data Exchange (ETDEWEB)

    Merle, P. [Service d' hepatogastroenterologie, hopital de l' Hotel-dieu, 1, place de l' Hopital, 69002 Lyon (France); Inserm U871, equipe ' Oncogenese hepatique et hepatites virales' , 151, cours Albert-Thomas, 69003 Lyon (France); Universite Claude-Bernard Lyon 1, IFR62 Lyon-Est, 8, avenue Rockefeller, 69008 Lyon (France); Mornex, F. [Departement de radiotherapie-oncologie, centre hospitalier Lyon-Sud, chemin du Grand-Revoyet, 69310 Pierre-Benite (France); equipe ' Ciblage therapeutique par les agents physiques' , EA 37-38, universite Claude-Bernard Lyon 1, 43, boulevard du 11-Novembre-1918, 69622 Villeurbanne cedex (France)

    2011-02-15

    Hepatocellular carcinoma is a poor prognosis tumour. The potential curative therapeutic options are ortho-topic liver transplantation, surgical resection and radiofrequency ablation. Unfortunately, only a minority of patients (around 20%) are eligible for these techniques. Thus, patients can benefit from palliative options, such as trans-arterial chemo-embolization (TACE) or sorafenib that bring only modest benefit on survival. Conformal radiotherapy allows delivering high dose radiation within a precise tumour volume while sparing the surrounding liver parenchyma. As employed in mono-therapy, conformal radiotherapy is highly efficient for small size hepatocellular carcinoma (< 5 cm). Above 5 cm, its efficacy is more limited but its association with TACE gives spectacular rates of complete responses. Controlled phase 2 or 3 trials are urgently warranted to define its indications in the therapeutic algorithm of hepatocellular carcinoma. (authors)

  1. Ductal in situ carcinoma: is it ethical to consider the breast conserving?; Carcinome canalaire in situ: est-il ethique de considerer le traitement conservateur comme un standard?

    Energy Technology Data Exchange (ETDEWEB)

    Barillot, I. [Centre de Lutte Contre le Cancer Georges-Francois-Leclerc, Dept. de Radiotherapie, 21 - Dijon (France); Cutuli, B. [Polyclinique de Courlancy, Service de Radiotherapie-Cancerologie, 51 - Reims (France); Arnould, L. [Centre de Lutte Contre le Cancer Georges-Francois-Leclerc, Service d' Anatomie Pathologique, 21 - Dijon (France)

    2004-02-01

    The increasing incidence of DCIS during the past 20 years needs a continuous evaluation of the treatment strategies and a multidisciplinary decision process. The management of the DCIS remains a challenging issue in 2003. Mastectomy should still be considered as the reference treatment which is able to guarantee cure in almost all cases, whereas breast conserving surgery followed by radiation therapy is associated with 7-10% of local recurrence. However, the increasing knowledge of the predictive factors of the local recurrence allows to propose a conservative treatment strategy to a large amount of patients, without negative impact on their prognosis. This review presents the arguments that permit to justify, the reasoned choice of the different therapeutic options according to the clinico-pathological situations. (author)

  2. Combination of endoscopic resection and external beam radiation therapy in bladder carcinoma; Association de resection endoscopique et de radiotherapie externe dans les carcinomes de la vessie

    Energy Technology Data Exchange (ETDEWEB)

    Kahlain, A.; Bouras, N.; Sahraoui, S.; Acharki, A.; Benider, A.; Samlali, R. [Centre d`oncologie Ibn Rochd, Casablanca (Morocco)

    1998-04-01

    The authors present results that were obtained by combining endoscopic resection and external beam radiation therapy in a population of 55 patients presenting with bladder cancer. They also explain the difficulties they encountered in the management of bladder cancer at the lbn Rochd Cancer Center (Casablanca, Morocco). (author)

  3. Post irradiation eardrum: a rare complication of the radiotherapy of naso-pharynx carcinomas; Necrose tympanique postradique: une complication rare de la radiotherapie des carcinomes nasopharynges

    Energy Technology Data Exchange (ETDEWEB)

    Siala, W.; Mnejja, W.; Daoud, J. [CHU Habib-Bourguiba, Service de Radiotherapie Oncologique, Sfax (Tunisia); Khabir, A. [CHU Habib-Bourguiba, Service d' Anatomopathologie, Sfax (Tunisia); Ghorbel, A. [CHU Habib-Bourguiba, Service d' ORL, Sfax (Tunisia); Frikha, M. [CHU Habib-Bourguiba, Service d' Oncologie Medicale, Sfax (Tunisia)

    2009-10-15

    The eardrum necrosis is a serious and dreadful complication but rarely described after irradiation of cavum cancers. We report in this work five cases of eardrum necrosis after radiotherapy of nasopharynx carcinomas. Patients and methods: between february 1993 and december 2004 239 patients suffering of anon metastatic nasopharynx cancer have been treated by classical irradiation associated or not to a chemotherapy. The radiotherapy was delivered at the dose of 70 to 75 Gy in the cavum and the ganglions initially reached according a classical modality of hyperfractionated one. We analysed retrospectively the delayed complications occurred six months or more after the radiotherapy beginning. Results: Five cases of eardrum necrosis were reported sixty five months after the end of radiotherapy. these patients suffered of hypoacusia and buzzing. The clinical examination allowed to bring out the eardrum perforation that did not exist before radiotherapy. The total dose of irradiation was 75 Gy for a patient and 71.5 Gy according a hyperfractionated modality for four patients. Three patients had an hearing prosthesis in order to improve their quality of life. Conclusion: the eardrum necrosis after radiotherapy for nasopharynx cancer is a rare and unusual complication, very few reported in the literature. The total dose of irradiation is considered as the principal factor of occurrence risk in such complication. (N.C.)

  4. NOTCH1 signaling contributes to cell growth, anti-apoptosis and metastasis in salivary adenoid cystic carcinoma

    OpenAIRE

    Su, Bo-hua; Qu, Jing; Song, Min; Huang, Xiao-yu; Hu, Xiao-meng; Xie, Jian; Zhao, Yong; Ding, Lin-can; She, Lin; Chen, Jiang; Lin, Li-song; Lin, Xu; Zheng, Da-li; Lu, You-guang

    2014-01-01

    Background: Numerous studies have reported both the tumor-suppressive and oncogenic roles of the Notch pathway, indicating that Notch activity regulates tumor biology in a complex, context-dependent manner. The aim of the present study was to identify the role of NOTCH1 in the cell growth and metastasis of SACC.

  5. Adenoid squamous carcinoma (pseudoangiosarcomatous carcinoma) of the vulva: a rare but highly aggressive variant of squamous cell carcinoma-report of a case and review of the literature.

    Science.gov (United States)

    Horn, Lars-Christian; Liebert, Uwe G; Edelmann, Jeanett; Höckel, Michael; Einenkel, Jens

    2008-04-01

    Pseudoangiosarcomatous squamous cell carcinoma is an unusual but aggressive variant of acantholytic squamous cell carcinoma of the vulva that mimics angiosarcoma on histology. We present a case of a 57-year-old woman with bilateral inguinal metastatic disease at the time of diagnosis, who died 4 months later because of distant metastatic disease to the lungs. Molecular analysis did not reveal any human papillomavirus infection. Because of the positive p53 immunostaining and the association to lichen sclerosus and simple type of high-grade vulvar intraepithelial neoplasia, alteration of p53 tumor suppressor gene might be involved in the pathogenesis of vulvar pseudoangiosarcomatous squamous cell carcinoma. However, further molecular studies are required. PMID:18317210

  6. Re-irradiation in stereotactic conditions and cetuximab for local relapses of epidermoid carcinoma of head and neck; Reirradiation en conditions stereotaxiques et cetuximab pour des recidives locales de carcinome epidermoide de la tete et du cou

    Energy Technology Data Exchange (ETDEWEB)

    Vasseur, F.; Comet, B.; Faivre-Pierret, M.; Coche-Dequeant, B.; Degardin, M.; Lefebvre, J.L.; Lacornerie, T.; Lartigau, E. [Departement universitaire de radiotherapie, centre Oscar Lambret, 59 - Lille (France); Universite Lille-2, 59 (France)

    2010-10-15

    The authors report a work aimed at assessing the feasibility and toxicity of a re-irradiation treatment in stereotactic conditions using CyberKnife and cetuximab in the case of local relapses of epidermoid cancers of the ORL sphere. Thirty three patients have been submitted to this treatment between June 2007 and April 2009. Although six patients died by six months, this treatment seems to be a good alternative, and presents an acceptable short-term toxicity. Further studies are needed to compare this technique to other therapeutic techniques, and to assess the risk of long term complications. Short communication

  7. {sup 99m}Tc-HMDP uptake mechanism in calcified transitional cell carcinoma; Mecanisme de fixation du {sup 99m}Tc-HMDP sur les carcinomes urotheliaux calcifies de vessie

    Energy Technology Data Exchange (ETDEWEB)

    Biyi, A.; Doudouh, A.; Oufroukhi, Y. [Hopital Militaire d' Instruction Mohammed-V, Service de Medecine Nucleaire, Rabat (Morocco); El Abbar, M. [Hopital Militaire d' Instruction Mohammed-V, Service d' Urologie, Rabat (Morocco); Al Bouzidi, A. [Hopital Militaire d' Instruction Mohammed-V, Service d' Anatomie Pathologique, Rabat (Morocco)

    2009-02-15

    We report a case of transitional cell carcinoma of the bladder visualized on a {sup 99m}Tc-HMDP bone scintigraphy. CT demonstrated irregular tumor of the bladder with curvilinear calcifications on the surface areas and multiple bilateral pulmonary metastases. Bone scintigraphy showed intense uptake corresponding to the bladder tumor and two bone metastases on the left femur. A few days later, the patient underwent retrograde injection of {sup 99m}Tc-HMDP into the bladder. Imaging made after voiding showed a tumour uptake of the skeletal labelled agent. Through this case report, we debate {sup 99m}Tc-bi-phosphonate uptake mechanisms in transitional cell carcinoma. (authors)

  8. Optimisation of combination radiotherapy and chemotherapy in non-small cell lung cancer; Optimisation de l`association radiotherapie et chimiotherapie dans les carcinomes bronchiques non a petites cellules

    Energy Technology Data Exchange (ETDEWEB)

    Bretel, J.J.; Arriagada, R.; Le Chevalier, T.; Baldeyrou, P.; Grunenwald, D.; Le Pechoux, C.; Pellae-Cosset, B.; Ruffie, P. [Institut Gustave Roussy, 94 - Villejuif (France)

    1997-09-01

    To report the results of CEBI 1 40 and 1 42 trials. These trials were aimed at improving the local control in stage III non-small cell carcinoma with concomitant chemotherapy and radiotherapy in the CEBI 140 trial, and with concomitant chemotherapy and radiotherapy followed by local excision in the CEBI 142 trial. In the CEBI 140 trial, all the patients received a complete course of radiotherapy, but the dose of cisplatin was decreased in 27 % of the cases, and the dose of vindesin in 88 %. There were two toxicity-related deaths. Three months after completion of the protocol, there were 50 % of complete responders. The overall survival rates at 1,2 and 3 years were 53, 33, and 11 % respectively, and disease-free survival rates 21, 11, and 11 %, respectively. In the CEBI 142 trial the immediate tolerance was good. Twenty-one patients (75 %) underwent surgical resection. Four tumors could not be resected. Resection was histologically incomplete in one case, and complete in the 16 remaining cases. With a median follow-up of 14 months, ten patients were alive and disease-free. Preliminary results of the CEBI 142 trial are encouraging. More patients and longer follow-up are needed for definitive conclusion. It would be of interest to implement a randomized trial comparing the CEBI 142 scheme and classical radiation therapy. (author). 11 refs.

  9. Neck dissection following chemo radiation for node positive head and neck carcinomas;Place du curage ganglionnaire apres chimioradiotherapie dans les carcinomes epidermoides des voies aerodigestives superieures avec atteinte ganglionnaire initiale (nasopharynx exclu)

    Energy Technology Data Exchange (ETDEWEB)

    Thariat, J. [Centre de lutte contre le cancer Antoine-Lacassagne, Dept. de Radiotherapie, Oncologie, 06 - Nice (France); IBDC CNRS UMR 6543, 06 - Nice (France); Thariat, J.; Marcy, P.Y.; Bozec, A.; Peyrade, F.; Hofman, P. [Universite de Nice-Sophia-Antipolis, 06 - Nice (France); Hamoir, M. [Cliniques universitaires Saint-Luc, UCL, Dept. de chirurgie ORL, Bruxelles (Belgium); Janot, F. [Institut Gustave-Roussy, Dept. de chirurgie ORL, 94 -Villejuif (France); De Mones, E. [CHU de Bordeaux, Dept. de chirurgie ORL, 33 - Bordeaux (France); Marcy, P.Y. [Centre de lutte contre le cancer Antoine-Lacassagne, Dept. de Radiologie, 06 - Nice (France); Carrier, P. [CHU de Nice, Dept. de Medecine Nucleaire, 06 - Nice (France); Bozec, I. [Centre de lutte contre le cancer Antoine-Lacassagne, Dept. chirurgie ORL, 06 - Nice (France); Guevara, J.; Santini, J. [CHU Pasteur, Dept. de chirurgie ORL, 06 - Nice (France); Albert, S. [CHU Bichat, Dept. de chirurgie ORL, 75 - Paris (France); Vedrine, P.O. [CHG Cannes, 06 (France); Graff, P. [Centre de Lutte Contre le Cancer Alexis-Vautrin, Dept. de chirurgie ORL, 54 - Nancy (France); Peyrade, F. [Centre de lutte contre le cancer Antoine-Lacassagne, Dept. d' Oncologie Medicale, 06 - Nice (France); Hofman, P. [CHU de Nice, Dept. de Pathologie clinique et experimentale, 06 - (France); Centre de lutte contre le cancer Antoine-Lacassagne, CHU et tumorotheque CHU-CLCC, 06 - Nice (France); Bourhis, J. [Institut Gustave-Roussy, Dept. de Radiotherapie-oncologie, 94 - Villejuif (France); Lapeyre, M. [Centre de lutte contre le cancer Jean-Perrin, Dept. de Radiotherapie-oncologie, 63 - Clermont-Ferrand (France)

    2009-12-15

    The optimal timing and extent of neck dissection in the context of chemo radiation for head and neck cancer remains controversial. For some institutions, it is uncertain whether neck dissection should still be performed up front especially for cystic nodes. For others, neck dissection can be performed after chemo radiation and can be omitted for N1 disease as long as a complete response to chemo radiation is obtained. The question is debated for N2 and N3 disease even after a complete response as the correlation between radiological and clinical assessment and pathology may not be reliable. Response rates are greater than or equal to 60% and isolated neck failures are less than or equal to 10% with current chemo radiation protocols. Some therefore consider that systematic up front or planned neck dissection would lead to greater than or equal to 50% unnecessary neck dissections for N2-N3 disease. Positron-emission tomography (PET) scanning to assess treatment response and have shown a very high negative predictive value of greater than or equal to 95% when using a standard uptake value of 3 for patients with a negative PET at four months after the completion of therapy. These data may support the practice of observing PET-negative necks. More evidence-based data are awaited to assess the need for neck dissection on PET. Selective neck dissection based on radiological assessment and preoperative findings and not exclusively on initial nodal stage may help to limit morbidity and to improve the quality of life without increasing the risk of neck failure. Adjuvant regional radiation boosts might be discussed on an individual basis for aggressive residual nodal disease with extra-capsular spread and uncertain margins but evidence is missing. Medical treatments aiming at reducing the metastatic risk especially for N3 disease are to be evaluated

  10. Epidermoid carcinomas of the anal canal treated with definitive radiation therapy in a series of 305 patients; Carcinomes epidermoides du canal anal traites par irradiation a visee curative: a propos de 305 patients

    Energy Technology Data Exchange (ETDEWEB)

    Deniaud-Alexandre, E.; Touboul, E.; Huang, R.; Qu, S.H.; Pene, F.; Schlienger, M. [Hopital Tenon, Service d' Oncologie-Radiotherapie, 75 - Paris (France); Tiret, E.; Parc, R. [Hopital Saint-Antoine, Service de Chirurgie Digestive, 75 - Paris (France); Sezeur, A. [Hopital des Diaconesses, Service de Chirurgie Generale, 75 - Paris (France); Houry, S. [Hopital Tenon AP-HP, Service de Chirurgie Digestive, 75 - Paris (France); Gallot, D. [Groupe Hospitalier Bichat-Claude-Bernard, Service de Chirurgie Generale et Digestive B, 75 - Paris (France)

    2003-08-01

    Purpose. - To identify prognostic factors and treatment toxicity in a series of epidermoid cancers of the anal canal without evident metastasis. Patients and methods. - Between June 1972 and January 1997, 305 patients (pts) were treated with curative-intent radiation therapy (RT). The T-stages according to the 1987 UICC classification were: 26 T1, 141 T2, 104 T3, and 34 T4. There were 49 pts with nodal involvement at presentation. Pretreatment anal function scoring according to our in-house system was: 22 scored 0, 182 scored 1, 74 scored 2, 7 scored 3. 11 scored 4, and 9 not available pts. The treatment started with external beam RT (EBRT) in 303 pts (median dose: 45 Gy). After a rest period of 4 to 6 weeks, a boost of 20 Gy was delivered by EBRT in 279 pts and by interstitial {sup 192}Ir brachytherapy (Bcy) in 17 pts. Seven pts received only one course of EBRT (mean dose: 49.5 Gy) and 2 pts were treated with interstitial {sup 192}Ir Bcy alone (55 and 60 Gy, respectively). concomitant chemotherapy (5-fluoro-uracil and either mitomycin C or cisplatin) was delivered to 19 pts. Mean follow-up was 103 months. Results. - At the end of RT local tumor clinical complete response (cCR) rate was 80%. Out of 61 non responders or local progressive tumors 27 (44%) were salvaged with abdomino-perineal resection (APR). The rate of local tumor relapse (LR) was 12%. Out of 37 LTR, 20 (54%) were salvaged with APR and one with interstitial {sup 192}Ir Bcy. The overall local tumor control (LC) rate with or without salvage local treatment was 84%. LC rate with a good anal function scoring (score 0 and 1) was 56.5%0. Among 181/186 available pts who preserved their anus, 94% had a good anal function scoring. For a subgroup of 15 pts with length tumor <2 cm-N0, the LC rate after the end of RT was 100% the LC rate with or without local salvage treatment was 100%, and among 13 available pts who preserved their anus, the anal function scoring was good in 12 pts (92%). The 10-years disease-free survival was 74%. After multivariate analysis, 3 independent predicting factors significantly influenced the disease-free survival: gap duration between 2 courses of RT (>38 days vs {<=}38 days, P=0.0025), pretreatment anal function scoring (0 vs 1 vs 2 vs 3 vs 4, P =4.4 10{sup -6}), and cCR after the end of RT (no complete response vs complete response, P =2.5 10{sup -14}). Conclusion. - We confirm excellent results with RT in T1 and T2 lesions. However, chemoradiotherapy should be preferred to improves survival free. of colostomy with a good anal sphincter function for tumors more than or equal to 2 cm in length and locally advanced tumors. (author)

  11. Significado clínico-patológico das expressões citofotométricas do Ki-67 e Caspase-3 no carcinoma de células escamosas do esôfago Clinicopathologic significance of the Ki-67 and Caspase-3 cytophotometric expressions in the esophageal squamous cell carcinomal

    Directory of Open Access Journals (Sweden)

    Gilmar Pereira Silva

    2008-06-01

    Full Text Available RACIONAL: A escolha da forma de tratamento do carcinoma de células escamosa de esôfago ainda hoje é orientada pelo estadiamento tumoral, onde as características histopatológicas do tumor são o maior determinante. Parale-lamente, desenvolvem-se estudos para entender o comportamento da biologia tumoral por método imunoistoquímico de quantificação manual, avaliando a ati-vidade proliferativa ou apoptótica do tecido em análise. As desvantagens conti-das no modo manual fizeram surgir e desenvolver método computadorizado de análise de imagem. OBJETIVOS: Verificar as expressões dos marcadores KI-67 e Caspase-3 e correlacioná-las com as características clínico-patológicas do tumor. MÉTODOS: Foram estudados 29 blocos parafinados provenientes de pa-cientes portadores de carcinoma de células escamosas de esôfago submetidos à esofagectomia e pertencentes a acervos de laboratórios de patologia. Proce-deu-se preparo das lâminas por técnica imunoistoquímica convencional. A quantificação da imunorreatividade às proteínas Ki-67 e Caspase-3 foi realizada pelo software de análise de imagem computadorizada SAMBA (Systeme d'Analyse Microphotometrique a Balayage Automatique através do índice de marcagem encontrado. RESULTADOS: Predominaram na amostra o sexo mascu-lino (82,7%; maiores de 50 anos; tumores moderadamente diferenciados (68,98%; estágio III (72,42%; lesões >3cm e localizadas no ? inferior do ór-gão. Os índices médios de marcagem identificados foram de 62,05% para o Ki-67 e 86,06% para a Caspase-3, e não mostraram correlação com as caracterís-ticas clínico-patológicas como sexo, idade, estadiamento tumoral, grau de pro-fundidade da lesão e comprometimento linfonodal. Houve significante diferença de expressão do Ki-67 entre os graus histológicos (P=0,047 e correlação entre os índices dos marcadores estudados (r=0,41 e P =0,032. CONCLUSÃO: Na presente investigação as atividades das proteínas estudadas se mostraram in-tensas sendo que a da Caspase-3 foi superior ao Ki-67 mas sem correlação com as características clínico-patológicas.BACKGROUND: The esophageal squamous cell carcinoma treatment strategy is still based on the tumor staging, where tumor histopathologic charac-teristics are the major determinants. In parallel, studies have been developed in order to better understand the tumor biology using immunohistochemical meth-ods with manual quantification evaluating the proliferative and apoptotic activi-ties of the cells. The disadvantages related to the manual method rose the de-velopment of computerized ways to do the image analysis. OBJETIVES: To verify the expressions of the markers Ki-67 (proliferative and Caspase-3 (apoptotic and to correlate them with the clinic and pathologic characteristics of the tumor. METHODS: Twenty-nine paraffin embedded blocks were studied, each one con-taining tissue samples from patients with esophageal squamous cell carcinoma submitted to esophagectomies. The clinic and pathological data were obtained from histopathologic informations and from medical records. The slides were prepared following the routine immunohistochemical method until the point to utilize the specific antibodies (MIB-1 and CPP32. Positive quantification of the immunoreactivity to the proteins Ki-67 and Caspase-3 was performed by the software for computerized image analysis SAMBA (Systeme d' Analyse Micro-photometrique a Balayage Automatique. Statistical analysis was done having P3cm; and lesions located in the lower third of the organ. The mean score indexes found were 62.05% for Ki-67 and 86.06% for Caspase-3 and there was no correlation with the clinic or pathologi-cal characteristics as gender, age and tumor staging. There was significant dif-ference of Ki-67 expression among the histological grades (P=0.047 and corre-lation between the evaluated indexes (r=0.41 and P=0.032. CONCLUSION: The protein expressions were high and the Caspase-3 protein activity was higher than the Ki-67, without correlation with clinic or pathological characteris

  12. Retrospective study of the local control and the cosmetic result of 147 face carcinomas after interstitial brachytherapy; Etude retrospective du controle local et du resultat cosmetique de 147 carcinomes de la face apres curietherapie interstitielle

    Energy Technology Data Exchange (ETDEWEB)

    Ducassou, A.; David, I.; Bonnet, J.; Delannes, M. [Institut Claudius-Regaud, Service de Radiotherapie, 31 - Toulouse (France)

    2009-10-15

    The purpose was to evaluate retrospectively the local control rate and the cosmetic results for patients that received an interstitial brachytherapy for a base or spino-cellular carcinoma of face orifices areas. The interstitial brachytherapy by iridium 192 is an excellent alternative to surgery in the skin carcinomas of the face, as well at the level of local control as the cosmetic and functional results. (N.C.)

  13. Preoperative concomitant radio chemotherapy in bulky carcinoma of the cervix: Institut Curie experience; Chimioradiotherapie concomitante preoperatoire dans les carcinomes du col uterin de stades IB2 a IIB: experience de l'Institut Curie

    Energy Technology Data Exchange (ETDEWEB)

    Kirova, Y.M.; Bourhaleb, Z.; Campitelli, M.; De la Rochefordiere, A. [Institut Curie, Groupe de Gynecologie, Service d' Oncologie et de Radiotherapie, 75 - Paris (France); Alran, S.; Fourchotte, V. [Institut Curie, Groupe de Gynecologie, Service de Chirurgie, 75 - Paris (France); Plancher, C. [Institut Curie, Groupe de Gynecologie, Service de Biostatistique, 75 - Paris (France); Beuzeboc, P.; Cottu, P. [Institut Curie, Groupe de Gynecologie, Service d' Oncologie Medicale, 75 - Paris (France); Petrow, P. [Institut Curie, Groupe de Gynecologie, Service de Radiologie, 75 - Paris (France); Cremoux, P. de; Sastre-Garau, X. [Institut Curie, Groupe de Pathologie, Service de Radiologie, 75 - Paris (France)

    2009-07-15

    Purpose: To evaluate the treatment results of patients (pts) with Figo stage IB2, IIA, IIB cervical carcinoma (C.C.) treated with preoperative radio chemotherapy, followed by extended radical hysterectomy. Patients and methods: Retrospective study of 148 women treated to the Curie Institute for operable Figo Stage IB2 to IIB, biopsy proved C.C.. Among them, 70 pts, median age 46 years, were treated using the same regimen associating primary radio cis-platinum based chemotherapy,intracavitary LDR brachytherapy, followed by extended radical hysterectomy. Kaplan-Meier estimates were used to draw survival curves. Comparisons of survival distribution were assessed by the log-rank test. Results: Complete histological local-regional response was obtained in 56% of the pts (n = 39). Residual macroscopic or microscopic disease in the cervix was observed in 28 pts (40%). All but one had in situ microscopic residual C.C.. Lateral residual disease in the parametria was also present in nine pts, all with residual C.C.. Pelvic lymph nodes were free from microscopic disease in 56 pts (80%). Eight of 55 (11%) radiological N0 patients had microscopic nodal involvement, as compared to 6/15 (40%) radiological N1 (p = 0.03). Seventeen pts (25%) had residual cervix disease but negative nodes. After median follow-up of 40 months (range, 8-141), 38/70 patients (54.1%) are still alive and free of disease, six (8.6%) alive with disease, and 11 (15.8%) patients were lost for follow-up but free of disease. Conclusion: The treatment of locally advanced C.C. needs a new multidisciplinary diagnostic and treatment approach using new therapeutic arms to improve the survival and treatment tolerance among women presenting this disease. (authors)

  14. Results of conservative treatment with surgery and radiation therapy of 132 non-palpable ductal carcinomas in situ of the breast; Resultats du traitement par chirurgie conservatrice et irradiation de 132 carcinomes canalaires in situ non palpables du sein

    Energy Technology Data Exchange (ETDEWEB)

    Amalric, R.; Brandone, H.; Dubau, A.; Hans, D.; Brandone, J.M.; Robert, F.; Pollet, J.F.; Amalric, F.; Rouah, Y.; Thomassin, L.; Giraud, D.; Henric, A.; Martin, P.M.; Romain, S. [Academie mediterraneenne d`oncologie clinique, Polyclinique Clairval, 13 - Marseille (France)

    1998-01-01

    Retrospective analysis of results of treatment of 132 subclinical ductal carcinomas in situ, non-palpable. Patients were treated with limited surgery and 70 Gy radiation therapy (70 Gy). With a median follow-up of 7 years, the total recurrence rate was 6 % and the actuarial rate at 5 years 4 % and at 10 years 13 % at. These have no influence on recurrence on the specific actuarial survival rate which was 100 % at 10 years. In spite of five infiltrating recurrences of seven, no metastasis appeared 48 months after the salvage surgery. The global rate of breast. The global rate of breast preservation was 92 % at 7 years. Therapeutic indications were developed taking into account the present analysis and a literature review (2,338 in situ ductal carcinomas, palpable or not, treated with conservative surgery, with or without adjuvant radio-therapy). (author)

  15. Class T4 (Stage 3B) epidermoid carcinomas of the anal channel; Carcinomes epidermoides du canal anal classes T4 (stade 3B): traitement conservateur par irradiation ou irradiation preoperatoire

    Energy Technology Data Exchange (ETDEWEB)

    Deniaud-Alexandre, E.; Touboul, E.; Huguet, F.; Pene, F.; Schlienger, M. [Hopital Tenon APHP, Service d' Oncologie-Radiotherapie, 75 - Paris (France); Tiret, E.; Parc, R. [Hopital Saint-Antoine, APHP, Service de Chirurgie Digestive, 75 - Paris (France); Sezeur, A. [Groupe Hospitalier des Diaconesses-Croix Saint-Simon, Service de Chirurgie Digestive, 75 - Paris (France); Hannoun, L. [Groupe Hospitalier Pitie-Salpetriere APHP, Service de Chirurgie Digestive, 75 - Paris (France); Houry, S. [Hopital Tenon APHP, Service de Chirurgie Digestive, 75 - Paris (France)

    2006-11-15

    The local control rate with a correct anal function is low after radiotherapy with curative aim with or without concomitant chemotherapy. For the patients whom the tumoral response is under 50% after the first irradiation fractions and/or that have a bad anal function even before therapy (scores 3-4), the sphincter preservation is compromised and the conservative treatment is questionable. (N.C.)

  16. Dealing with initial chemotherapy doses: a new basis for treatment optimization in limited small-cell lung cancer; Importance de la dose initiale de chimiotherapie dans le traitement des carcinomes bronchiques a petites cellules: perspectives therapeutiques

    Energy Technology Data Exchange (ETDEWEB)

    Le Chevalier, T.; Le Cesne, A.; Arriagada, R. [Centre de Lutte Contre le Cancer Gustave-Roussy, 94 - Villejuif (France)

    1995-12-31

    Treatment of patients with small-cell lung cancer (SCLC) remains disappointing despite high initial complete response rates. The dramatic initial chemosensitivity of tumor cells is frustrated by the early emergence of chemoresistant clonogenic cells, regardless of front line treatments. Although the dose relationship is fairly well established regarding the response rate, its effect on survival is inconclusive. From 1980 to 1988, 202 patients with limited SCLC were included in four consecutive protocols using an alternating schedule of thoracic radiotherapy and chemotherapy. Despite an increase of chemotherapy and/or total radiation doses, no significant difference was observed between the four protocols in terms of response rate, disease free and overall survival. However, a retrospective analysis performed on a total of 131 consecutive patients led us to propose the hypothesis that a moderate increase in the initial dose, ie first course, of cisplatin and cyclophosphamide could improve overall survival. From 1988 to 1991, 105 patients were subsequently included in a large randomized trial raising this question. The treatment difference only concerned the initial doses of cisplatin (80 vs 100 mg/m{sup 2}) and cyclophosphamide (900 vs 1200 mg/m{sup 2}). The trial was closed after inclusion of 105 patients, 32 months after the start of the study because at that time overall survival was significantly better in the higher-dose group (p = 0.001). The emergence of this debatable concept opens new directions in the therapeutic strategy of SCLC and the contribution of hematopoietic growth factors may be a great interest in the management of this disease. (authors). 27 refs., 1 tab.

  17. Treatment of hepatocellular carcinoma by intra-arterial injection of {sup 131}I labeled iodized oil (Lipiocis); Traitement des carcinomes hepatocellulaires par injection intraarterielle hepatique d`huiles iodees radiomarquees (Lipiocis)

    Energy Technology Data Exchange (ETDEWEB)

    Raoul, J.L. [Centre Eugene-Marquis, 35 - Rennes (France)

    1995-12-31

    When injected into the hepatic artery of patients with hepatocellular carcinoma (HCC), Lipiodol was demonstrated to remain selectively for a long time within the tumors. Biodistribution studies have shown that 80% of Lipiodol was retained by the liver, with a tumor/liver ratio of 4,5 and an effective half life of 5,5 d. The injection of a therapeutic activity (2,2 GBq) was well tolerated and associated with a response rate of 40%. Thereafter two phase II trials were initiated. In the first one the survival rate of HCC patients with portal vein thrombosis treated with Lipiocis was demonstrated to be significantly longer than that of a control group. In the second study, comparing Lipiocis to chemoembolization, preliminary results have shown that both treatments were as effective but that Lipiocis was significantly better tolerated than chemoembolization. (author). 7 refs., 2 figs.

  18. Gingival metastasis from the lung through a needle and a pin: a case report; Un carcinome pulmonaire metastase a la gencive via une aiguille de couture: a propos d'un cas

    Energy Technology Data Exchange (ETDEWEB)

    Hentati, D.; Chraiet, N.; Kochbati, L.; Maalej, M. [Institut Salah-Azaiz, Service de Radiotherapie Carcinologique, Tunis (Tunisia)

    2007-12-15

    Gingival metastases are very rare. We report the case of a 47 year-old man presenting with a gingival metastasis from a non small cell lung carcinoma. According to the literature, the most probable way of spread of such metastasis is hematogenous. Local implantation of cancer cells, present in patient's expectoration, in a fragile gingival may be an other pathway of lung cancer metastasizing in this region as we will try to describe in this case report. Cytological and/or histological investigation is needed to assess the malignant and the metastatic character of these gingival lesions. A rapid regression is observed after a flash of external beam radiation; nevertheless metastasis prognosis depends on the primary tumour progress. (authors)

  19. Clear cell carcinoma of the larynx: one case report and review of the literature; Carcinome a cellules claires du larynx: revue de la litterature, a propos d'un cas

    Energy Technology Data Exchange (ETDEWEB)

    Sahraoui, S.; Acharki, A.; Kahlain, A.; Belaabidia, B.; Sqali, S. [Centre Hospitalier Universitaire Ibn Rochd, Casablanca (Morocco)

    2001-04-01

    Clear cell carcinoma of the larynx is exceptional. Only six cases are described in the literature. We report a new case occurring in a 58-year-old man. The treatment consisted of a total laryngectomy with lymph node dissection followed by adjuvant irradiation. Local and regional recurrence occurred after 5 months. The patient died from the tumor's evolution 12 months after the diagnosis. The prognosis of clear cell carcinoma of the larynx is similar to the clear cell carcinoma of the lung and is unfavorable. (authors)

  20. Significado clínico-patológico das expressões citofotométricas do Ki-67 e Caspase-3 no carcinoma de células escamosas do esôfago / Clinicopathologic significance of the Ki-67 and Caspase-3 cytophotometric expressions in the esophageal squamous cell carcinomal

    Scientific Electronic Library Online (English)

    Gilmar Pereira, Silva; Osvaldo, Malafaia; Ronaldo Máfia, Cuenca; Jurandir Marcondes, Ribas-Filho; Paulo Afonso Nunes, Nassif; Carmen Australia Paredes Marcondes, Ribas; Jorge Luiz de Matos, Zeve.

    2008-06-01

    Full Text Available RACIONAL: A escolha da forma de tratamento do carcinoma de células escamosa de esôfago ainda hoje é orientada pelo estadiamento tumoral, onde as características histopatológicas do tumor são o maior determinante. Parale-lamente, desenvolvem-se estudos para entender o comportamento da biologia tumora [...] l por método imunoistoquímico de quantificação manual, avaliando a ati-vidade proliferativa ou apoptótica do tecido em análise. As desvantagens conti-das no modo manual fizeram surgir e desenvolver método computadorizado de análise de imagem. OBJETIVOS: Verificar as expressões dos marcadores KI-67 e Caspase-3 e correlacioná-las com as características clínico-patológicas do tumor. MÉTODOS: Foram estudados 29 blocos parafinados provenientes de pa-cientes portadores de carcinoma de células escamosas de esôfago submetidos à esofagectomia e pertencentes a acervos de laboratórios de patologia. Proce-deu-se preparo das lâminas por técnica imunoistoquímica convencional. A quantificação da imunorreatividade às proteínas Ki-67 e Caspase-3 foi realizada pelo software de análise de imagem computadorizada SAMBA (Systeme d'Analyse Microphotometrique a Balayage Automatique) através do índice de marcagem encontrado. RESULTADOS: Predominaram na amostra o sexo mascu-lino (82,7%); maiores de 50 anos; tumores moderadamente diferenciados (68,98%); estágio III (72,42%); lesões >3cm e localizadas no ? inferior do ór-gão. Os índices médios de marcagem identificados foram de 62,05% para o Ki-67 e 86,06% para a Caspase-3, e não mostraram correlação com as caracterís-ticas clínico-patológicas como sexo, idade, estadiamento tumoral, grau de pro-fundidade da lesão e comprometimento linfonodal. Houve significante diferença de expressão do Ki-67 entre os graus histológicos (P=0,047) e correlação entre os índices dos marcadores estudados (r=0,41 e P =0,032). CONCLUSÃO: Na presente investigação as atividades das proteínas estudadas se mostraram in-tensas sendo que a da Caspase-3 foi superior ao Ki-67 mas sem correlação com as características clínico-patológicas. Abstract in english BACKGROUND: The esophageal squamous cell carcinoma treatment strategy is still based on the tumor staging, where tumor histopathologic charac-teristics are the major determinants. In parallel, studies have been developed in order to better understand the tumor biology using immunohistochemical meth- [...] ods with manual quantification evaluating the proliferative and apoptotic activi-ties of the cells. The disadvantages related to the manual method rose the de-velopment of computerized ways to do the image analysis. OBJETIVES: To verify the expressions of the markers Ki-67 (proliferative) and Caspase-3 (apoptotic) and to correlate them with the clinic and pathologic characteristics of the tumor. METHODS: Twenty-nine paraffin embedded blocks were studied, each one con-taining tissue samples from patients with esophageal squamous cell carcinoma submitted to esophagectomies. The clinic and pathological data were obtained from histopathologic informations and from medical records. The slides were prepared following the routine immunohistochemical method until the point to utilize the specific antibodies (MIB-1 and CPP32). Positive quantification of the immunoreactivity to the proteins Ki-67 and Caspase-3 was performed by the software for computerized image analysis SAMBA (Systeme d' Analyse Micro-photometrique a Balayage Automatique). Statistical analysis was done having P3cm; and lesions located in the lower third of the organ. The mean score indexes found were 62.05% for Ki-67 and 86.06% for Caspase-3 and there was no correlation with the clinic or pathologi-cal characteristics as gender, age and tumor staging. There was significant dif-ference of Ki-67 expression among the histological grades (P=0.047) and corre-lation between the evaluated indexes (r=0.41 and P=0.032). CONCLUSION: The protein expressions were high and the Caspase-3 protein activity was higher than the Ki-67, without correlat

  1. Nasopharynx carcinoma treatment: from the conventional radiotherapy to the conformal radiotherapy with intensity modulation; Traitement du carcinome du nasopharynx: de la radiotherapie conventionnelle a la radiotherapie conformationnelle avec modulation d'intensite

    Energy Technology Data Exchange (ETDEWEB)

    Mokaouim, K.; Grehange, G.; Truc, G.; Peingnaux, K.; Martin, E.; Zanetta, S.; Bruchon, Y.; Bonnetain, F.; Maingon, P. [Centre Georges-Francois Leclerc, 21 - Dijon (France)

    2009-10-15

    The objective of this study was to evaluate retrospectively the impact of factors linked to the radiotherapy realisation on the local and locoregional control, the global survival, the survival without disease of patients suffering of naso-pharynx carcinoma. Conclusion: the patients suffering of a nasopharynx carcinoma treated by irradiation associated to chemotherapy have an improved global survival and an improved survival without disease. The conformal radiotherapy with or without modulated intensity reduce the risk of serous otitis, trismus and xerostomia at long term. It seems necessary to realize multi centric studies with a longer period of follow up before asserting the advantages of the I.M.R.T. in comparison to the classical and conformal technique in the treatment of naso-pharynx carcinomas. (N.C.)

  2. Ulcere de Marjolin: complication redoutable des sequelles de brûlures

    OpenAIRE

    Ouahbi, S.; Droussi, H.; Boukind, S.; Dlimi, M.; Elatiqi, O. K.; Elamrani, M. D.; Benchamkha, Y.; Ettalbi, S.

    2013-01-01

    L’ulcère de Marjolin désigne la transformation maligne d’une cicatrice de brûlure ou de toute autre plaie ou ulcération chronique. Le type histologique prédominant reste le carcinome épidermoïde, et il est caractérisé par son agressivité locale, des métastases plus fréquentes, un risque de récurrence et une mortalité plus importante que les carcinomes épidermoïdes classiques. Notre travail est une étude rétrospective portant sur 21 cas d’ulcère de Marjolin, colligés ...

  3. Kyste hydatique pulmonaire chez l'enfant traité par thoracoscopie: huit ans d'expérience

    OpenAIRE

    Khattala, Khalid; Elmadi, Aziz; Rami, Mohamed; Bouamama, Hanan; Bouabdallah, Youssef

    2013-01-01

    L’échinococcose kystique est une pathologie fréquente en zone d'endémie: pourtour méditerranéen, Afrique de l'est et l'Amérique du Sud. L'hydatidose reste à l'heure actuelle un problème majeur de santé publique. Notre travail consiste en une étude rétrospective de 27 malades opérés pour kyste hydatique pulmonaire (KHP) par thoracoscopie, au service de chirurgie pédiatrique du centre hospitalier universitaire HASSAN II à Fès, sur une période de huit ans allant de janvier 200...

  4. Carninome intracanalaire (in situ) du sein : pouvons-nous raisonnablement éviter la radiothérapie pour certaines patientes opérées ?

    OpenAIRE

    Coucke, Philippe; Barthelemy, Nicole; Jansen, Nicolas; Trivie?re, N.; Jerusalem, Guy

    2008-01-01

    Dans le cadre de la prise en charge multidisciplinaire du carcinome intracanalaire du sein (carcinome intra-canalaire in situ = DCIS = Ductal Carcinoma In Situ), on évoque souvent la possibilité de renoncer à la radiothérapie complémentaire après un geste de chirurgie conservatrice. S’il est vrai que la radiothérapie, dans ce contexte, n’apporte pas de bénéfice en survie, il n’en reste pas moins qu’on observe à long terme un effet bénéfique en contrôle local. Il existe un...

  5. Prospective study of accerelated postoperative radiation therapy in patients with squamous-cell carcinoma of the head and neck

    OpenAIRE

    Zouhair, A.; Coucke, Philippe; Azria, D.; Pache, P.; Stupp, R.; Moeckli, R.; Mirimanoff, R. O.; Ozsahin, M.

    2003-01-01

    Résumé Objectif de l’étude. – Évaluer la faisabilité et la tolérance de la radiothérapie externe accélérée postopératoire des carcinomes épidermoïdes localement évolués de la sphère ORL. Patients et méthodes. – De décembre 1997 à juillet 2001, nous avons inclus 68 patients (52 hommes, 16 femmes), d’un âge médian de 60 ans (variant de 43–81 ans), opérés avec intention curative d’un carcinome épidermoïde ORL de stades pT1-4 et/ou pN0-3 M0. Il s?...

  6. Is Transnasal Endoscopic Examination Necessary Before and After Adenoidectomy?

    OpenAIRE

    Y?ld?r?m, Yavuz Selim; Apuhan, Tayfun; Aksoy, Fadlullah; Veyseller, Bayram; O?zturan, Orhan

    2012-01-01

    The present study aimed to investigate the amount of residual adenoid tissue following the conventional adenoidectomy as compared with preoperative values. A total of 32 girls and 44 boys (range, 3–15 years) in whom adenoidectomy procedure was planned were included in the study. Adenoid tissue sizes before adenoidectomy and residual tissue sizes after conventional curettage adenoidectomy were measured by transnasal endoscopic examination and were recorded. Adenoid tissue size before and af...

  7. Mammographic appearance of posttraumatic and postoperative leasons in the female breast simulating a tumor

    International Nuclear Information System (INIS)

    There are posttraumatic and postoperative leasons of the female breast which caused different pictures. You see sometimes typically pictures like lipid-filled thin-walled cysts with or without calcification of the walls. On the other side, there are mammographic pictures simulating a carcinoma - a differentiation between carcinoms and fat necrosis is in these cases not possible. (orig.)

  8. CGP74514A Enhances TRAIL-induced Apoptosis in Breast Cancer Cells by Reducing X-linked Inhibitor of Apoptosis Protein.

    Czech Academy of Sciences Publication Activity Database

    Park, S.; Shim, S.M.; Nam, S.H.; And?ra, Ladislav; Suh, N.; Kim, I.

    2014-01-01

    Ro?. 34, ?. 7 (2014), s. 3557-3562. ISSN 0250-7005 R&D Projects: GA MŠk LH12202 Institutional support: RVO:68378050 Keywords : TRAIL * Apoptosis * Breast carcinom Subject RIV: EB - Genetics ; Molecular Biology Impact factor : 1.872, year: 2013

  9. Concomitant chemoradiotherapy with folfox-cetuximab in stage III oesophagus and cardia carcinomas: final results of the phase-II Erafox study of the Gercor group; Chimioradiotherapie concomitante par folfox-cetuximab dans les carcinomes du cardia et de l'oesophage de stade III: resultats definitifs de l'etude de phase II Erafox du groupe Gercor

    Energy Technology Data Exchange (ETDEWEB)

    Lledo, G.; Mammar, V.; Michel, P. [Hopital Jean-Mermoz, Lyon (France); Dahan, L. [CHU Rouen, Rouen (France); Mineur, L.; Dupuis, O. [Institut Sainte-Catherine, 84000 Avignon (France); Galais, M.P. [CHU Timone, Marseille (France); Chibaudel, B. [InstitutJean-Godinot, Reims (France); Jovenin, N. [Gercor, Paris (France); Gramont, A. de [Hopital Saint-Antoine, Paris (France)

    2011-10-15

    The authors report and discuss the results of a French national multicentre study which aimed at assessing the efficiency and tolerance of a folfox- and cetuximab-based chemotherapy concomitant with a radiotherapy for the treatment of stage-III cardia and oesophagus cancers. Patients (60 men and 19 women) have been selected according to the carcinoma type, performance index, age, weight loss over the last six months. Results are discussed in terms of response, steadiness, advancement, grade 3 and 4 toxicity, and side effects. The therapeutic efficiency corresponds to an objective response rate of 77 per cent, and tolerance profile seems to be acceptable for patients suffering from locally advanced cardia and oesophagus cancer. Short communication

  10. Combination of radiotherapy and cetuximab for patients suffering from of an advanced and non operable epidermoid carcinoma of the ORL sphere: results and side effects; Association de radiotherapie et de cetuximab chez des patients atteints d'un carcinome epidermoide de la sphere ORL evolue non operable: resultats et effets secondaires

    Energy Technology Data Exchange (ETDEWEB)

    Acevedo, C.; Valette, G.; Bouchekoua, M.; Marianowski, R.; Pradier, O. [CHU Morvan, 29 - Brest (France)

    2010-10-15

    The authors report a retrospective survey of a set of locally advanced epidermoid carcinomas treated by irradiation and cetuximab. They assessed the response to the treatment, the specific survival, and the global survival as well as the tolerance. The survey is based on 31 men and 5 women suffering from different stage 4 non-metastatic advanced epidermoid carcinomas of the ORL sphere. Short communication

  11. Metastatic calcifications of hyperparathyroidism detected by M.D.P.- Tc 99 m bone scintigraphy in patients with parathyroid carcinoma: A case report; Les calcifications metastatiques de l'hyperparathyroidie identifiees par scintigraphie osseuse au M.D.P.-Tc 99 m dans le cadre du carcinome parathyroidien: a propos d'un cas

    Energy Technology Data Exchange (ETDEWEB)

    Doudouh, A.; Biyi, A.; Oufroukhi, Y.; Zekri, A. [Hopital Militaire Mohammed-5, Service de Medecine Nucleaire, Rabat (Morocco); Sekkach, Y. [Hopital Militaire Mohammed-5, Service de Medecine B, Rabat (Morocco)

    2008-02-15

    The authors report a case of gastric, renal, pulmonary, and myocardial uptake of M.D.P.-Tc 99 m in a patient with parathyroid carcinoma. Parathyroid carcinoma is a rare cause of primary hyperparathyroidism which becomes complicated during its evolution by metastatic calcifications. Metastatic calcifications are frequently located in lungs and heart. If an adequate treatment is not undertaken, these calcifications progress and evolve into severe respiratory and cardiac complications. In our patient, quasi-complete disappearance of metastatic calcifications on the follow-up bone scintigraphy, performed four weeks after surgical cure of parathyroid tumour, indicates the great interest of this examination in early identification of metastatic calcifications and monitoring of their disappearance after treatment. (authors)

  12. Check-up and follow-up of papillary and follicular thyroid carcinoma in the department of nuclear medicine at Ibn Sina hospital Rabat; Bilan et surveillance des carcinomes papillaire et vesiculaire de la thyroide dans le service de medecine nucleaire de l'hopital Ibn Sina de Rabat

    Energy Technology Data Exchange (ETDEWEB)

    Ben Rais Aouad, N.; Ghfir, I.; Guerrouj, H.; Fellah, S.; Rahali, J.; Ksyar, R.; Missoum, F.; Bssis, A.; Azrak, S. [CHU Ibn Sina, Service de Medecine Nucleaire, Rabat (Morocco)

    2009-10-15

    In the department of nuclear medicine at Ibn Sina university hospital. Thyroid carcinoma follow-up strategy has been modified and includes cervical ultrasonography and thyroglobulin measurement. The role of radio-iodine scanning in the management of differentiated thyroid carcinoma is decreasing. Papillary and follicular carcinoma have good prognosis but late metastases exist and can lead to death. A lifelong follow-up is therefore mandatory. The main goal of follow-up is to detect earlier persistent or recurrent disease. (authors)

  13. Tolerance and efficacy of conformal radiotherapy for hepatocellular carcinoma in cirrhotic patients. Results of the French RTF1 phase 2 trial; Tolerance et efficacite de la radiotherapie de conformation en cas de carcinome hepatocellulaire chez le patient cirrhotique. Resultats de l'essai de phase II RTF1

    Energy Technology Data Exchange (ETDEWEB)

    Mornex, F.; Girard, N.; Wautot, V.; Khodri, M. [Centre Hospitalier Lyon-Sud, Dept. de Radiotherapie-Oncologie, 69 - Pierre-Benite (France); Merle, P.; Kubas, A.; Trepo, C. [Hopital de l' Hotel-Dieu, Service d' hepatogastroenterologie, 69 - Lyon (France); Beziat, C. [Hopital de l' Hotel-Dieu, Dept. de Radiologie, 69 - Lyon (France)

    2005-11-15

    Purpose. - While some patients presenting with hepatocellular carcinoma (HCC) benefit from curative therapies (transplantation, surgery, percutaneous ablation), others are only candidates for palliative options such as chemo-embolization or symptomatic care. Although conventional external-beam radiotherapy of the liver is regarded as little efficient and potentially toxic in cirrhotic patients, 3-dimensional conformal radiotherapy (CRT), by decreasing the amount of normal liver included in the radiation portal, allows dose escalation to occur without increasing the risk of radiation-induced hepatitis. This trial was designed to assess the efficacy and tolerance of CRT for small-size HCC in cirrhotic patients. Patients and methods. - Prospective phase II trial including stage A/B cirrhotic patients with small-size HCC not suitable for curative treatments; CRT consisted in a standard fractionation radiation, with a total dose of 66 Gy. Results. - Twenty-seven patients were included, 15 of whom had previously been treated for HCC; mean age was 68. Among the 23 assessable patients, 18 (78%) presented with complete response, 3 (13%) with partial response, and 2 with no response. Acute complications occurred in 24 patients, and were mainly acceptable (grade 1/2: 22 patients, grade 3/4: 11 patients, 4 (15%) of whom had clinical and/or hematological toxicities). Only 2 (9%) grade 3/4 clinical and/or hematological late toxicities are reported. Conclusion. - CRT is a non-invasive curative technique highly suitable for small-size HCC in cirrhotic patients; further investigations are needed to compare it to the other available treatments, and to integrate it into the curative therapeutic algorithm of HCC. (author)

  14. Intra-arterial injection of lipid nano-capsules charged in rhenium-188, for the treatment of hepatocellular carcinomas among the rat; Injection intra-arterielle de nanocapsules lipidiques chargees en rhenium-188, pour le traitement des carcinomes hepatocellulaires chez le rat

    Energy Technology Data Exchange (ETDEWEB)

    Vanpouille, C.; Lacoeuille, F.; Hindre, F. [Inserm U646, Angers, (France); Roux, J. [service commun animalerie, hospitalo-universitaire, Angers, (France); Aube, C. [service de radiologie, CHU d' Angers, (France); Oberti, F. [service de gastro-enterologie et hepatologie, CHU d' Angers, (France); Lejeune, J.J.; Couturier, O. [service de medecine nucleaire, CHU d' Angers, (France)

    2009-05-15

    The objective of this study was to evaluate the therapy efficiency of the {sup 188}Re incorporated in the middle of lipid capsules (N.C.L. {sup 188}Re-S.S.S.) on a hepato carcinoma model of rat. The preliminary results are encouraging and show the efficiency of a single injection of N.C.L.{sup 188}Re-S.S.S. in a hepato carcinoma model of rat. (N.C.)

  15. Thyroid medullary carcinoma and PET/CT with {sup 18}F-DOPA in the post surgery follow up: preliminary results; Carcinome medullaire de la thyroide et TEP/TDM a la {sup 18}F-DOPA dans le suivi post-chirurgical: resultats preliminaires

    Energy Technology Data Exchange (ETDEWEB)

    Keomany, J.; Rust, E.; Constantinesco, A.; Imperiale, A. [CHU de Strasbourg, Service de biophysique et medecine nucleaire, 67 (France); Detour, J. [CHU de Strasbourg, Service de radiopharmacie, 67 (France); Chabrier, G.; Goichot, B. [CHU de Strasbourg, Service de medecine interne, endocrinologie et nutrition, 67 (France); Schneegans, O. [FNCLCC Paul-Strauss, 67 - Strasbourg (France)

    2010-07-01

    Purpose: to study the contribution of the PET/CT with {sup 18}F DOPA in the therapy follow-up of patients with a history of medullary thyroid carcinoma and biological suspicion of residual disease or recurrence. Conclusions: The preliminary results show the interest of the PET/CT with {sup 18}F DOPA in the therapy follow-up and the management of patients suffering of medullary thyroid carcinoma in biological relapse. (N.C.)

  16. Thyroid medullar carcinoma and therapy follow up with the help of PET/T.D.M. with {sup 18}F-DOPA: about four cases; Carcinome medullaire de la thyroide et suivi therapeutique a l'aide de la TEP-TDM a la 18F-DOPA: a propos de quatre cas

    Energy Technology Data Exchange (ETDEWEB)

    Imperiale, A.; Ben-sellem, D.; Keomany, J.; Constantinesco, A. [Biophysique et medecine nucleaire, CHU de Strasbourg, (France); Detour, J.; Beretz, L. [radiopharmacie, CHU de Strasbourg, (France); Chabrier, G.; Goichot, B. [medecine interne et nutrition, CHU de Strasbourg, (France)

    2009-05-15

    The objective was to study the contribution of the PET-T.D.M. to the dihydro phenylalanine labelled with {sup 18}F ({sup 18}F-DOPA) in the therapy follow up of patients with antecedents of thyroid medullar carcinomas and suspicion of biological recurrence. In spite of the very preliminary character of these results, these first cases show the interest of the PET-T.D.M. with {sup 18}F-DOPA in the therapy follow up and the coverage of patients reached by thyroid medullar carcinoma in biological recurrence. (N.C.)

  17. First chemotherapy by docetaxel, cisplatin and 5-fluoro-uracil (T.P.F.) followed by concomitant chemoradiotherapy in the treatment of cavum locally evolved undifferentiated carcinomas without metastases; Chimiotherapie premiere par docetaxel, cisplatine et 5-fluoro-uracile (TPF) suivie de chimioradiotherapie concomitante dans le traitement des carcinomes indifferencies localement evolues non metastatiques du cavum

    Energy Technology Data Exchange (ETDEWEB)

    Sahli, B.; Bali, M.S.; Miles, I.; Djemaa, A. [CHU Benbadis, Constantine (Algeria)

    2009-10-15

    It is a prospective study in order to evaluate the feasibility and the toxicity of a chemotherapy by docetaxel, cisplatin and 5-fluoro-uracil followed by a concomitant chemoradiotherapy in the treatment of non metastatic locally evolved undifferentiated carcinomas of the cavum. The conclusion was despite the low number of patients in our series, the observed results show that this neoadjuvant chemotherapy followed by a concomitant chemoradiotherapy in the locally evolved undifferentiated carcinomas of the cavum is feasible. however, the high acute toxicity needs the use of conformal irradiation techniques. Besides, a longer follow up is necessary to evaluate the therapy efficiency and the delayed toxicity of this protocol. (N.C.)

  18. Conservative treatment of epidermoid carcinomas of the anal duct by external irradiation followed by low dose rate brachytherapy by iridium 192; Traitement conservateur des carcinomes epidermoides du canal anal par irradiation externe suivie de curietherapie de bas debit de dose par Iridium 192

    Energy Technology Data Exchange (ETDEWEB)

    Minsat, M.; Moureau-Zabotto, L.; Giovannini, M.; Lelong, B.; Viret, F.; Bories, E.; Tallet, A.; Salem, N. [Institut Paoli-Calmettes, 13 - Marseille (France)

    2007-11-15

    The association of external radiotherapy and brachytherapy is an efficient loco regional treatment of epidermoid carcinomas of the anal duct with an acceptable delayed toxicity rate and a high rate of the sphincter function conservation. (N.C.)

  19. Interest of the SPECT-CT to D.M.S.A.-V images merging in the management of thyroid medullary carcinomas; Interets de la fusion d'image TEMP-TDM au DMSA-V dans la prise en charge des carcinomes medullaires de la thyroide

    Energy Technology Data Exchange (ETDEWEB)

    Menemani, A.; Mebarki, M.; Slama, A.; Khellil, N.; Meghelli, S.; Lachachi, B.; Krim, M.; Merad, S.; Berber, N. [CHU Tlemcen, Service de medecine nucleaire (Algeria)

    2010-07-01

    Purpose: hybrid imaging associating SPECT and CT, integers functional and anatomical data. The aim of this communication is to present the contribution of the SPECT coupled to CT with D.M.S.A. V. in our daily practice of the medullary thyroid carcinomas management. Conclusions: the SPECT/CT got by a system of images merging allows a better anatomical location and improves the management of thyroid medullary carcinomas. (N.C.)

  20. Operable bulky stages IB and 2 squamous-cell carcinomas of uterine cervix treated with combined primary radiation therapy and surgery; Carcinomes epidermoides du col uterin operables de stades IB et 2 de gros volume traites par irradiation premiere et chirurgie

    Energy Technology Data Exchange (ETDEWEB)

    Bernard, A.; Touboul, E.; Deniaud-Alexandre, E. [Hopital Tenon, Oncologie-Radiotherapie, 75 - Paris (France); Lefranc, J.P.; Blondon, J. [Groupe Hospitalier la Pitie-Salpetriere, Chirurgie Gynecologique, 75 - Paris (France); Genestie, C. [Groupe Hospitalier la Pitie-Salpetriere, Anatamopathologie, 75 - Paris (France); Uzan, S. [Hopital Tenon, Gynecologie Obstetrique, 75 - Paris (France)

    2002-04-01

    Operable bulky stages IB and II squamous-cell carcinomas of uterine cervix treated with combined primary radiation therapy and surgery. Purpose. - To identify prognostic factors and treatment toxicity in a series of operable bulky stages I and II cervical carcinomas treated with a therapeutic modality combining primary irradiation and surgery. Patients and methods. - Between July 1982 and May 1996, 66 patients with bulky squamous-cell cervical carcinomas (stages IB2, IIA, and IIB with 1/3 proximal parametrial invasion) underwent primary external beam pelvic radiation therapy (37.40 Gy to 40 Gy over 4.5 weeks) and low-dose. (author)

  1. Radiosensitivity of centro pelvis carcinomas of the uterine cervix with a diameter higher than 4 cm. Study of prognosis factors of the tumor response; Radiosensibilite des carcinomes centropelviens du col uterin de diametre superieur a 4 cm. Etude des facteurs pronostiques de la reponse tumorale

    Energy Technology Data Exchange (ETDEWEB)

    Le Floch, O.; Ryo, N.; Garaud, P.; Calais, G.; Bougnoux, P.; Lansac, J.; Body, G. [Hopital Bretonneau, 37 - Tours (France)

    1998-09-01

    In this study, has been recovered four parameters in interaction with the tumor radiosensitivity of the carcinomas of the uterine cervix. The hemoglobinemia was this one that had the highest importance. These data confirm the importance of the relation between tissues oxygenation and the radiosensitivity of the uterus carcinomas. (N.C.)

  2. Statistical study of a series of 672 carcinomas of the cervix: results and complications according to age and modalities of treatment; Etude statistique d`une serie de 672 carcinomes du col uterin. Resultats et complications selon l`age et les modalites de traitement

    Energy Technology Data Exchange (ETDEWEB)

    Pernot, M.; Hoffstetter, S.; Peiffert, D.; Carolus, J.M.; Guillemin, F.; Verhaeghe, J.L.; Marchal, C.; Luporsi, E.; Beckendorf, V.; Stines, J.; Aletti, P.; Dartois, D.; Lesur, A.; Bey, P. [Centre de Lutte Contre le Cancer, 54 - Nancy (France)

    1995-12-31

    The study on 672 infiltrating carcinomas of the cervix treated from 1977 until the end of 1991, by a radiosurgical combination or by exclusive irradiation. The radiosurgical series includes stages 1 B and II and patients under 50 years because of the therapeutic protocol. Most of the patients over 50 years and all stages III were treated by exclusive irradiation. External beam irradiation was most often performed in 4 fields by linear accelerator of 12 and 25 MeV. Utero vaginal brachytherapy used the technique of molds. In 55 cases, a complementary interstitial brachytherapy was applied on residual node. A computer dosimetry was made for each patient with calculation of the doses delivered to organs at risk and to node areas . The results at 5 years are as follows for the total series: locoregional control (LRC) 79%, specific survival (SS) 73%, overall survival 70%. For stage I, the LRC of the radiosurgical series is 92%, that of the series of exclusive irradiation 87%. For stage II, the LRC is 70% in the radiosurgical series and 79% in the series of exclusive irradiation. Conversely, for distal stage II, the difference is very significant in favour of exclusive irradiation (LRC 31%/77%, SS 26%/70%). If we consider the results according to age, the difference for distal stage II comes mostly from patients under 50 years and especially those aged 40 years or under. For stage III, the LRC is 61% for patients over 50 years and 34% for those aged 50 years or under. As the nodes, the results of surgical pieces and lymphadenectomy are studied. The patients under 40 years in stages II and III present more metastases than others. Among the therapeutic factors, the dose rate and the treatment duration were particularly studied. A detailed study of the complications is made for the radiosurgical series as for the series of exclusive irradiation according to the French Italian glossary of complications as well as a study of the factors inducing them.

  3. Ulcere de Marjolin: complication redoutable des sequelles de brûlures

    Science.gov (United States)

    Ouahbi, S.; Droussi, H.; Boukind, S.; Dlimi, M.; Elatiqi, O.K.; Elamrani, M.D.; Benchamkha, Y.; Ettalbi, S.

    2013-01-01

    Summary L’ulcère de Marjolin désigne la transformation maligne d’une cicatrice de brûlure ou de toute autre plaie ou ulcération chronique. Le type histologique prédominant reste le carcinome épidermoïde, et il est caractérisé par son agressivité locale, des métastases plus fréquentes, un risque de récurrence et une mortalité plus importante que les carcinomes épidermoïdes classiques. Notre travail est une étude rétrospective portant sur 21 cas d’ulcère de Marjolin, colligés au service de chirurgie plastique du CHU Mohammed VI de Marrakech, avec pour but de relever les aspects épidémiologiques, thérapeutiques et évolutifs de cette pathologie. L’amélioration du pronostic nécessite non seulement un diagnostic et un traitement précoce, mais surtout une attitude préventive qui consiste en des greffes cutanées précoces et des soins réguliers de toute cicatrice de brûlure. PMID:24799850

  4. Métastases gastro-intestinales du cancer du sein: à propos de 2 cas

    OpenAIRE

    Loubna, Mezouar; Mohamed, El Hfid; Tijani, El Harroudi; Fouzia, Ghadouani; Hanane, Haj Kacem; Zouhour, Bourhaleb; Asmae, Ouabdelmoumen

    2013-01-01

    Le cancer du sein est le cancer le plus fréquent chez la femme, notamment au Maroc, avec un taux de mortalité élevé. Les métastases gastro-intestinales d'un carcinome canalaire du sein sont rares. Leur diagnostic est difficile du fait de la nature non spécifique des symptômes. Nous rapportons deux observations originales de métastases gastroduodénales d'un cancer canalaire infiltrant du sein. Les métastases gastro-intestinales du cancer du sein sont très rares; la présence de symp...

  5. Genetic Alterations in Colorectal Cancer

    OpenAIRE

    Armaghany, Tannaz; Wilson, Jon D.; Chu, Quyen; Mills, Glenn

    2012-01-01

    Colorectal cancer (CRC) is the third most common cancer in men and the second most common cancer in women worldwide. Both genetic and epigenetic alterations are common in CRC and are the driving force of tumorigenesis. The adenoma-carcinoma sequence was proposed in the 1980s that described transformation of normal colorectal epithelium to an adenoma and ultimately to an invasive and metastatic tumor. Initial genetic changes start in an early adenoma and accumulate as it transforms to carcinom...

  6. Prevalence of Anti?EBV Antibodies in Adult Patients with Nasopharyngeal Carcinoma During 2003?2007 In Isfahan, Iran

    OpenAIRE

    Mokhtari M.; Hashemi Jazi M; Ah, Davarpanah Jazi

    2008-01-01

    Background: Nasopharyngeal carcinoma (NPC) is a nonlymphomatous squamous cell carcinoma (SCC) that occurs in the epithelial lining of the nasopharynx. Viral, geographic, and ethnic factors are responsible for its multifactorial futures. Previous studies have showed the role of Epstein-Barr virus (EBV) in the pathogenesis of NPC but no study has been conducted on the Iranian population to assess the etiology of NPC and to investigate the role of EBV in carcinogenesis of nasopharyngeal carcinom...

  7. Apport de la microscopie electronique dans la compréhension des mécanismes d'interactions entre nanoparticules et cellules biologiques

    OpenAIRE

    Rima, Wael

    2012-01-01

    Parmi les nanoparticules aptes à accompagner la radiothérapie en clinique, les nanoparticules à base d'oxyde de gadolinium paraissent pertinentes, de part leur multimodalité en imagerie et leur effet radiosensibilisant prouvé in vitro et in vivo. Cet effet de radiosensibilisation est exceptionnel notamment sur des cellules cancéreuses radiorésistantes de la lignée SQ20B (carcinome squameux tête et cou) et uniquement pour des doses modérées de nanoparticules (aux alentours de 0.6 mM...

  8. Highly pathogenic avian influenza A virus H5N1 NS1 protein induces caspase-dependent apoptosis in human alveolar basal epithelial cells

    OpenAIRE

    Liu Xuelin; Zhou Xiaowei; Yang Yutao; Zhang Chuanfu; Song Hongbin; He Yuxian; Huang Peitang

    2010-01-01

    Abstract Background It is widely considered that the multifunctional NS1 protein of influenza A viruses contributes significantly disease pathogenesis by modulating a number of virus and host-cell processes, but it is highly controversial whether this non-structural protein is a proapoptotic or antiapoptotic factor in infected cells. Results NS1 protein of influenza A/chicken/Jilin/2003 virus, a highly pathogenic H5N1 strain, could induce apoptosis in the carcinomic human alveolar basal epith...

  9. Infiltration of M2 Tumor-Associated Macrophages in Oral Squamous Cell Carcinoma Correlates with Tumor Malignancy

    OpenAIRE

    Jun Shimada; Miki Hiroi; Kazumasa Mori; Yoshihiro Ohmori

    2011-01-01

    Tumor-associated macrophages (TAMs) are a major cellular component in the tumor microenvironment of many solid tumors. The functional competence of TAMs varies depending on the type of tumors and their respective microenvironments. The classically activated M1 macrophages exhibit antitumor functions, whereas the alternatively activated M2 macrophages exhibit protumor functions that contribute to tumor development and progression. Although TAMs have been detected in oral squamous cell carcinom...

  10. Expression of Trop2 Cell Surface Glycoprotein in Normal and Tumor Tissues: Potential Implications as a Cancer Therapeutic Target

    OpenAIRE

    Stepan, Lara P.; Trueblood, Esther S.; Hale, Kari; Babcook, John; Borges, Luis; Sutherland, Claire L.

    2011-01-01

    Trop2 is a cell-surface glycoprotein reported to be overexpressed in various types of adenocarcinomas with minimal expression in normal tissues. Recent findings that Trop2 expression correlates with tumor aggressiveness have increased interest in Trop2 as a potential target for cancer immunotherapy. The goal of this study was to extensively evaluate Trop2 expression at the transcript and protein levels in normal and tumor tissues. It was determined that Trop2 is overexpressed on some carcinom...

  11. Long term follow-up in patients with a naso-pharynx carcinoma after induction chemotherapy by cisplatin, 5-fluoro-uracil and bleomycin (pbf) followed by a bi-fractionated radiotherapy and a consolidation chemotherapy; Survie a long terme chez des patients atteints d'un carcinome du nasopharynx apres chimiotherapie d'induction par cisplatine, 5-fluoro-uracile et bleomycine (pbf) suivie d'une radiotherapie bifractionnee et une chimiotherapie de consolidation

    Energy Technology Data Exchange (ETDEWEB)

    Djekkoun, R.; Boudaoud, K.; Ferdi, N.; Filali, T. [CAC CHU, Constantine (Algeria)

    2009-10-15

    The purpose of this study was to evaluate the efficiency and the long term survival after neoadjuvant chemotherapy by cisplatin, 5-fluoro-uracil and bleomycin, followed by a bi fractionated radiotherapy and an adjuvant chemotherapy. The protocol associating a P.B.F. type chemotherapy in the locally evolved disease is justified by its efficiency in terms of objective response rate and local control rate, that expressed by an improvement of the global survival rate and survival without disease at five and ten years. The adjuvant chemotherapy is very toxic and did not show any benefit. (N.C.)

  12. Coblation Assisted Tonsillectomy

    Medline Plus

    Full Text Available ... children had almost no pain or didn’t require any pain medication. I have had comments from ... adenoids. NORMAN SANDERS, M.D. Are your postoperative results similar for chronic tonsillitis versus hypertrophy? EARL HARLEY, ...

  13. Drug: D06938 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D06938 Formula, Drug Keigairengyoto Scutellaria root [DR:D06688], Phellodendron bark [DR:D06689] ... ]) Empyema; Chronic rhinitis; Chronic adenoiditis; Acne ... Therapeutic category: 5200 Therapeutic category of ...

  14. Management of difficult airway by retrograde tracheal intubation

    International Nuclear Information System (INIS)

    A case of difficult intubation is presented in a patient of adenoid carcinoma with a large right-sided facial defect. She was managed with radiotherapy and a myocutaneous flap reconstruction was done with retrograde tracheal intubation. (author)

  15. Tonsillitis

    Science.gov (United States)

    ... the child talks Noisy breathing during the day Snoring at night Both the tonsils and the adenoid ... a short period of time at night during snoring or loud breathing (this is called "sleep apnea"). ...

  16. Coblation Assisted Tonsillectomy

    Medline Plus

    Full Text Available ... to visualize the adenoids. These are clamps and red tubes that we use to retract the palate ... aspiration, of saline or blood. And it also leads to much smoother emergence and avoids any potential ...

  17. Medline Plus

    Full Text Available ... Hospital Boston, Boston, MA, 1/28/2009) Immune System Tonsils and Adenoids Coblation Assisted Tonsillectomy (Georgetown University ... Gables, FL, 6/18/2008) Kidneys and Urinary System Kidney Cancer Newest Surgical Option for Kidney Cancer ( ...

  18. Coblation Assisted Tonsillectomy

    Medline Plus

    Full Text Available ... this because I think this is, in my mind, the procedure of choice for tonsillectomy in children, ... HARLEY, M.D. Yes, you can. As a matter of fact, this child had his adenoids out ...

  19. Coblation Assisted Tonsillectomy

    Medline Plus

    Full Text Available ... Bovey. Overall, the parents had a better perceived postoperative outcome. One of the most serious complications of ... for adenoids. NORMAN SANDERS, M.D. Are your postoperative results similar for chronic tonsillitis versus hypertrophy? EARL ...

  20. Oral Cancer Removal and Palate Reconstruction

    Medline Plus

    Full Text Available ... second division of the trigeminal nerve toward the brain. 00:13:55 Adenoid cystic carcinoma is particularly ... which is what is the risk to the injury of facial nerve branches? 00:46:39 J. ...

  1. Otolaryngologist: What Is an Otolaryngologist?

    Science.gov (United States)

    ... Otolaryngology: diseases in children with special ENT problems including birth defects of the head and neck and developmental delays. Treating : ear infection (otitis media), tonsil and adenoid infection, airway problems, asthma and allergy/sinus disease, neck tumors. Rhinology: disorders ...

  2. Les kystes hydatiques du foie rompus dans les voies biliaires: à propos de 120 cas

    Science.gov (United States)

    Moujahid, Mountassir; Tajdine, Mohamed Tarik

    2011-01-01

    Etude rétrospective rapportant une série de kystes hydatiques rompus dans les voies biliaires colligés dans le service de chirurgie de l'hôpital militaire Avicenne à Marrakech. Entre 1990 à 2008, sur 536 kystes hydatiques du foie opérés dans le service, 120 étaient compliqués de rupture dans les voies biliaires soit 22,38%. Il y avait 82hommes et 38 femmes. L’âge moyen était de 35 ans avec des extrêmes allant de 10 à 60 ans. La clinique était dominée par la crise d'angiocholite ou une douleur du flanc droit. L'ictère était isolé dans huit cas. La fistule biliokystique était latente dans plus de 50% des cas. Le traitement a consisté en une résection du dôme saillant dans103cas (85,84%), une périkystectomie chez 11 malades (9,16%) et une lobectomie gauche dans six cas (5%). Le traitement de la fistule bilio kystique a consisté en une suture chez 36malades et un drainage bipolaire dans 25 cas, La déconnexion kysto-biliaire ou cholédocotomie trans hépatico kystique selon Perdomo était pratiquée dans 49cas et une anastomose bilio-digestive cholédoco-duodénale dans 10 cas. La durée moyenne d'hospitalisation était de 20jours. Nous déplorons deux décès par choc septique et un troisième par encéphalopathie secondaire à une cirrhose biliaire. La morbidité était représentée par huit abcès sous phrénique, douze fistules biliaires prolongées et deux occlusions intestinales. Les kystes hydatiques rompus dans les voies biliaires représentent la complication la plus grave de cette pathologie bénigne. Le traitement repose sur des méthodes radicales qui sont d'une efficacité reconnue, mais de réalisation dangereuse et les méthodes conservatrices, en particulier la déconnexion kysto-biliaire qui est une méthode simple et qui donne de bons résultats à court et à long terme. PMID:22384289

  3. Lipid and ganglioside alterations in tumor cells treated with antimitotic oleyl glycoside

    OpenAIRE

    Garci?a A?lvarez, Isabel; Egido-gaba?s, Meritxell; Romero-rami?rez, Lorenzo; Doncel-pe?rez, Ernesto; Nieto-sampedro, Manuel; Casas, Josefina; Ferna?ndez-mayoralas, Alfonso

    2011-01-01

    Oleyl 2-acetamido-2-deoxy-?-D-glucopyranoside (1) was previously shown to exhibit antimitotic activity on glioma (C6) and melanoma (A375) cell lines. Preliminary studies about its mechanism of action using 1H MAS NMR suggested that 1 may be altering the metabolism of lipids. We have now studied the effect of 1 on the fatty acid, sphingolipid and ganglioside content in a line of carcinomic human alveolar epithelial cells (A549) using UPLC-MS. Oleic acid and NB-DNJ were used as positive contro...

  4. Une tumeur rare et distincte du cancer du sein: le carcinosarcome, à propos de huit cas et revue de la littérature

    OpenAIRE

    Ghanem, Samia; Khoyaali, Siham; Naciri, Sara; Glaoui, Meriem; Mesmoudi, Mohamed; Errihani, Hassan

    2013-01-01

    Le carcinosarcome du sein souvent appelé carcinome métaplasique du sein, est une tumeur maligne rare composée de deux lignées cellulaires distinctes, il est décrit comme un cancer du sein de type canalaire avec un composant de type sarcome. Il représente 0,08-0.2% de toutes les tumeurs malignes du sein. Il s'agit d'une étude rétrospective étalée sur un an, huit cas des carcinosarcomes mammaires ont été colligés à l'Institut national d'oncologie au Maroc durant l'année 2007. La ...

  5. Osteolytic metastasis detected by F18-FDG PET in a patient with lung carcinoma

    OpenAIRE

    Gonza?lez Sistal, A?ngel; Baltasar Sa?nchez, Alicia; Sa?nchez Salmo?n, Aida; Ruibal Morell, A?lvaro

    2013-01-01

    We present a 53-year-old man with a vocal cord paralysis observed as a primary manifestation of lung carcinoma. Tc-99m MDP whole body bone scan were performed and resulted a normal scintiscan. The bone scan does not revealed suspicious foci of uptake. The possibility of bone metastasis was taken into consideration. A whole body F18-FDG-PET scan showed intense uptake in the left upper lung corresponding to the primary tumor. A bronchial biopsy confirmed infiltration by small cell lung carcinom...

  6. La tumeur de Buschke-Lowenstein anorectale: à propos de 16 cas et revue de la littérature

    Science.gov (United States)

    Njoumi, Noureddine; Tarchouli, Mohamed; Ratbi, Moulay Brahim; Elochi, Mohamed Reda; Yamoul, Rajae; Hachi, Hafid; Bougtab, Abdesslam

    2013-01-01

    La tumeur de Buschke-Lowenstein est une affection rare appartenant au groupe des carcinomes verruqueux. Elle survient le plus souvent chez des sujets pubères en pleine activité sexuelle. Une infection par human papillomavirus (HPV) 6 et 11 est volontiers associée à ces tumeurs. Elle se caractérise par la fréquence des récidives et le risque de transformation maligne. Son traitement est difficile même si l'histologie confirme la bénignité. A partir de 16 observations de TBL et d'une revue de la littérature, les auteurs soulignent les aspects épidémiologiques, cliniques, thérapeutiques et évolutifs de cette affection. PMID:24847393

  7. Développements statistiques et algorithmiques pour l'analyse des cancers du sein de type triple négatif

    OpenAIRE

    Rigaill, Guillem

    2010-01-01

    Dans le monde, le cancer du sein est le cancer le plus fréquent de la femme. Plusieurs types de cancer du sein ont été mis en évidence. Les carcinomes infiltrants triple négatif (TNBC) sont l'un de ces types. Les TNBC sont parmi les plus agressifs cancers du sein et sont associés à un mauvais pronostique. Il n'y a pas encore de traitement dédié pour ces cancers. Cette thèse avait pour but d'identifier des gènes et des voies de signalisation dérégulés dans les cancers de types TN...

  8. Prospective study of factors of prognosis of survival without disease and of global five year and ten-year survival in a series of 90 patients suffering from a stage IIB or III cervical epidermoid carcinoma which had been treated by concomitant chemo-radiotherapy; etude prospective des facteurs pronostiques de survie sans maladie et de survie globale a cinq et dix dans une serie de 90 patientes atteintes d'un carcinome epidermoide du col uterin de stade IIB ou III dont le traitement etait une chimioradiotherapie concomitante

    Energy Technology Data Exchange (ETDEWEB)

    Ferdi, N.; Djekkoun, R.; Aouati, E.; Chirouf, A.; Aouati, S.; Afiane, M. [CHU de Constantine (Algeria)

    2011-10-15

    The authors report the study of some factors (TNM stage, tumour size, histological sub-type and haemoglobin concentration) of survival without disease and of global survival by analyzing the files of 90 patients who had chemotherapy concomitantly with external radiotherapy (five 1,8 Gy sessions a week for four to five weeks) followed by utero-vaginal curietherapy. It appears that chemo-radiotherapy is well tolerated and that some factors very significantly affect global survival and survival without disease. Concomitant chemo-radiotherapy significantly delays the occurrence of recurrence and metastases, notably for locally advanced tumours. Short communication

  9. Characterisation of regulatory T cells in nasal associated lymphoid tissue in children: relationships with pneumococcal colonization.

    Science.gov (United States)

    Zhang, Qibo; Leong, Samuel C; McNamara, Paul S; Mubarak, Ayman; Malley, Richard; Finn, Adam

    2011-08-01

    Regulatory T cells (Treg) diminish immune responses to microbial infection, which may contribute to preventing inflammation-related local tissue damage and autoimmunity but may also contribute to chronicity of infection. Nasopharyngeal carriage of pneumococcus is common in young children and can persist for long periods but it is unknown whether the presence of Treg in the nasopharynx contributes to this persistence. We have investigated the numbers and activities of Foxp3+Treg in adenoidal tissues and their association with pneumococcal carriage in children. Expression of Treg cell-related markers including Foxp3, CD25, CD39, CD127 and CLTA4 were analysed by flow-cytometry in adenoidal mononuclear cells (MNC) and PBMC from children. Unfractionated MNC or Treg-depleted MNC were stimulated with a pneumococcal whole cell antigen (WCA) and T cell proliferation measured. Cytokine production by MNC was measured using a cytometric bead array. Higher numbers of CD25(high)Foxp3(high) Treg expressing higher CD39 and CTLA4 were found in adenoidal MNC than in PBMC. Children with pneumococcus positive nasopharyngeal cultures had higher proportions of Treg and expressed higher levels of CD39 and CTLA-4 than those who were culture negative (-). WCA induced adenoidal Treg proliferation which produce IL10 but not IL17, and CD4 T cell proliferation in Treg-depleted MNC was greater in pneumococcal culture positive than negative children. Significant numbers of Treg with an effector/memory phenotype which possess a potent inhibitory effect, exist in adenoidal tissue. The association of pneumococcal carriage with an increased frequency of adenoidal Treg suggests that Treg in nasal-associated lymphoid tissue (NALT) may contribute to the persistence of pneumococcus in children. Further studies to determine what component and mechanisms are involved in the promotion of Treg in NALT may lead to novel therapeutic or vaccination strategy against upper respiratory infection. PMID:21852948

  10. Neuralgia associated with transcutaneous electrical nerve stimulation therapy in a patient initially diagnosed with temporomandibular disorder.

    Science.gov (United States)

    Omolehinwa, Temitope T; Musbah, Thamer; Desai, Bhavik; O'Malley, Bert W; Stoopler, Eric T

    2015-03-01

    Head and neck neoplasms may be difficult to detect because of wide-ranging symptoms and the presence of overlapping anatomic structures in the region. This case report describes a patient with chronic otalgia and temporomandibular disorder, who developed sudden-onset neuralgia while receiving transcutaneous electrical nerve stimulation (TENS) therapy. Further diagnostic evaluation revealed a skull base tumor consistent with adenoid cystic carcinoma. To our knowledge, this is the first report of TENS-associated neuralgia leading to a diagnosis of primary intracranial adenoid cystic carcinoma. PMID:25660829

  11. Male breast cancer: 22 case reports at the National Hospital of Niamey- Niger (West Africa Le cancer du sein chez l'homme: à propos de 22 cas a l'Hôpital National de Niamey- Niger (Afrique de l'Ouest

    Directory of Open Access Journals (Sweden)

    Nouhou Hassane

    2009-11-01

    Full Text Available BACKGROUND: Male breast cancer (MBC is rare. The objective of the study is to report clinicopathological characteristics, treatment patterns, and outcomes of MBC. METHODS: This study, which includes two parts (retrospective and prospective, focused on all hospitalized male patients with breast cancer during 17 years (1992–2008 with histological confirmation. RESULTS: The series included 22 patients. The mean age was 52.8 years (range: 28–80 years. MBC represented 5.7% of all breast cancers. Most patients had an advanced disease with skin ulceration and inflammation T3 (31.9% and T4 (59.1%. The majority of patients came from rural areas (63.6%. The duration of signs ranged from 1 to 7 years. Histology found infiltrating ductal carcinoma in 14 cases (63.6%, sarcoma in 3 cases (13.6%, papillary carcinoma in 2 cases (9%, and lobular carcinoma, medullar carcinoma, and mucinous carcinoma in 4.6% each of the others cases. The treatment had consisted of a radical mastectomy (Halsted or Patey in 19 cases (86.4% with axillary clearance and incomplete resection in 3 cases (13.6%. In the retrospective study follow-up of 14 patients, we lost sight of 13 patients 6 months after surgery. In the prospective study of 8 patients 10 to 36 months after mastectomy, 4 patients were deceased (50%, 4 were alive with 1 case having a local recurrence and pulmonary metastasis. CONCLUSION: The advanced clinical forms of MBC are most frequent with skin ulceration and nodal enlargement. The absence of radiotherapy and the low access of chemotherapy limited the treatment to radical mastectomy (Halsted in the majority of cases. OBJECTIF : Le cancer du sein chez l’homme (CSH est une affection rare .Le but de cette étude est de déterminer les caractéristiques clinicopathologiques, les résultats du traitement et l’évolution du CSH. Méthodologie : Il s’agit d’étude comportant 2 volets (rétrospectif et prospectif. Etaient inclus tous les patients de sexe masculin présentant un cancer de sein pendant 17 ans de 1992 à 2006 avec preuve histologique. RESULTATS : La série comportait 22 cas. L’age moyen était de 52,8 ans (Extrêmes : 28 et 80 ans. Le CSH représentait 5,7% des cancers du sein. Les tumeurs étaient cliniquement avancées avec des formes ulcéro-hémorragiques et inflammatoires T3 (31.9% and T4 (59.1%. La majorité des patients provenaient des zones rurales (63.6%. Les signes évoluaient de 1 à 7 ans. L’examen histologique a retrouvé un carcinome canalaire infiltrant dans 14 cas (63,6%, le fibrosarcome dans 3 cas (13,6%, le carcinome papillaire dans 2 cas (9% et les autres types dans 1 cas chacun (4,6% : le carcinome lobulaire, carcinome médullaire, le carcinome épidermoïde .La mastectomie radicale (Patey ou Halsted avec curage ganglionnaire axillaire été réalisée dans 19 cas (86,4%, et dans 3 cas (13,6% une exérèse incomplète. L’évolution : dans l’étude rétrospective 13 patients perdus de vue 6 mois après la mastectomie. Dans l’étude prospective après un recul de 10 à 36 mois il a été enregistré 4 décès (50% et 4 patients sont vivant et un cas avec de récidive locale et métastases hépatiques. CONCLUSION : Le CSH est rare mais non exceptionnel. Le stade est évolué au moment diagnostic et le pronostic est grave. Dans notre environnement la mastectomie radicale constitue dans la plupart des cas le seul moyen thérapeutique lié au faible accès de la radio chimiothérapie.

  12. Dasatinib in Treating Patients With Recurrent or Metastatic Malignant Salivary Gland Tumors

    Science.gov (United States)

    2015-04-02

    High-grade Salivary Gland Mucoepidermoid Carcinoma; Low-grade Salivary Gland Mucoepidermoid Carcinoma; Recurrent Salivary Gland Cancer; Salivary Gland Acinic Cell Tumor; Salivary Gland Adenocarcinoma; Salivary Gland Adenoid Cystic Carcinoma; Salivary Gland Anaplastic Carcinoma; Salivary Gland Malignant Mixed Cell Type Tumor; Salivary Gland Poorly Differentiated Carcinoma; Salivary Gland Squamous Cell Carcinoma; Stage IV Salivary Gland Cancer

  13. Swelling of the floor of the mouth: a clinical dilemma.

    Science.gov (United States)

    Califano, L; Zupi, A; Longo, F; Coscia, G; Piombino, P

    1996-09-01

    Swelling of the floor of the mouth is sometime difficult to diagnose clinically. Lithiasis and neoplasm are the most frequent causes of intraoral swelling. Also after plain radiology and computed tomography the diagnosis is often dubious. A case of swelling of the floor of the mouth due to an adenoid cystic carcinoma of the sublingual gland is reported. PMID:9487738

  14. Types of Cancer Teens Get

    Science.gov (United States)

    ... lymphatic system , which includes the lymph nodes, thymus, spleen, adenoids, tonsils, and bone marrow. The lymph system functions in the body by fighting off germs that cause infection and illness. Most teens with lymphoma have either Hodgkin's lymphoma or non-Hodgkin's lymphoma . ...

  15. Drug: D06933 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D06933 Formula, Drug Kikyoto Glycyrrhiza [DR:D04365], Platycodon root [DR:D06703] Adenoiditis; P ... gs in Japan [BR:br08301] 5 Crude drugs and Chinese medicine ... formulations 52 Traditional Chinese medicine s 520 ... Traditional Chinese medicine s 5200 Traditional Chinese medicine s D06933 Kikyoto ...

  16. Coblation Assisted Tonsillectomy

    Medline Plus

    Full Text Available ... of the Bovey, but the planes are, as you know, are not charred, so there’s no thermal injury. ... device work for adenoids? EARL HARLEY, M.D. You oftentimes must bend the coblation in order to gain access, so it inserts in here. ...

  17. Multiple head and neck neoplasia following radiation for benign disease during childhood

    International Nuclear Information System (INIS)

    A woman received radiation therapy to the adenoids for benign disease at the age of 10 years and subsequently developed an adenocarcinoma of the middle ear, a parathyroid adenoma, and a papillary carcinoma of the thyroid gland in adulthood. This appears to be the first such case on record. The literature of neoplasia after head and neck irradiation is briefly reviewed

  18. Oral Cancer Removal and Palate Reconstruction

    Medline Plus

    Full Text Available ... first question was, can this reconstruction be done after resection two years ago for a polymorphous low grade adenocarcinoma of ... Scanning post-op. Unfortunately, with adenoid cystic carcinoma, many of these patients may recur years down the road, albeit. So, typically, with a ...

  19. Inflammatory cytokine detection in adenotonsill and peripheral blood mononuclear cells- culture in adenotonsillectomy patients: a comparative study

    Directory of Open Access Journals (Sweden)

    Farhadi M

    2013-04-01

    Full Text Available Background: Tonsils and adenoid hypertrophy is a major respiratory symptom in children which is partly due to recruitment of inflammatory cells in upper airway lymph nodes as a result of the effects of synthesis and release of different inflammatory cytokines. It seems that infections play role in concert with these cytokines leading to tonsilar hypertrophy and other pathologic consequences. It is proposed that cellular infiltrate of tonsils and adenoids may secrete different quantities of these cytokines compared with peripheral blood mononuclear cells (PBMC cultures.Methods: Among patients who were admitted for adenotonsillectomy to the ENT ward, 37 patients, under 1-12 years old patients with fulfill criteria selected to include the study. Excised adenoid and tonsils cultured and inflammatory cytokines Interferon-? (INF-?, Interlukine-1 (IL-1, IL-6, IL-8 and tumor necrosis factor-? (TNF-? measured in cellular culture supernatant. The same cytokines measured in PBMC cultures.Results: The data shows that there is a significant difference between IFN-? and IL-8 amounts in adenoid tissue culture supernatant and PBMC culture of our patients. Furth-ermore, the amounts of IFN-?, IL-1 and IL-8 showed considerable difference between tonsilar tissue culture supernatant and PBMC culture of these patients. Although there is a significant correlation between IL-6 amounts in tissue culture supernatant and PBMC culture (P=0.02, the respective data for TNF is only almost significant.Conclusion: Inflammatory cytokines may have significant role in the early provoke of inflammation occurred in hypertrophied tonsils and adenoid. The majority of these cyt-okines increase the expression of adhesion molecules on epithelial cells and influence the recruitment of leucocytes and inflamed tonsils. On the other hand lack of sufficient cytokine release may lead to persistent infections and may cause chronic inflammation and hypertrophied tissue.

  20. Neuroendocrine tumor of the skin of head and neck

    Directory of Open Access Journals (Sweden)

    Stoši? Srboljub

    2005-01-01

    Full Text Available Background. Merkel cell carcinom is a rare neuroendrocine tumor of skin which manifests it self through aggressive growth and early regional metastasis. It develops mainly in older population. Locally, the tumor spreads intracutaneously. Case report. We showed two cases (females of 89 and 70 years old hospitalized within the last two years. The first patient was treated surgically three times. After the surgery, the patient was treated with radio therapy, and died 3 years from the beginning of the treatment. The second patient with this neuroendocrine tumor with the high malignancy potential and huge regional metastasis, was treated surgically, and died a month and a half after the operation. Conclusion. These two cases confirmed the aggressive and recidivant growth of this tumor with the difficult pathologic investigation, and the extremely bad prognosis inspite of the treatment.

  1. In vitro NMR spectroscopy of healthy, mastopathically modified and carcinomatous breast tissue samples correlated with histological findings

    International Nuclear Information System (INIS)

    Of 57 patients with clinically suspected mamma carcinoma 121 samples were analysed by in vitro 1H-NMR spectroscopy at 300 MHz and correlated with histological data. Within the relevant spectral region between 2.7 and 4.1 ppm strong signals were observed from fat, (phosphoryl-) choline, (phospho-) creatine, and carnitine. Furthermore, with high regularity, 8 weak, partly overlapping signals were resolved and attributed to glucose, glycine, threonine, serine, inositol, and sucrose. Their intensities were determined by an iterative fitness program. From the intensity ratios, different kinds of tissue could be distinguished based on spectroscopic criteria. Healthy or mastopathically modified tissue could be discriminated from more than 50% carcinomally affected tissue with a specificity of better than 99.5%. This fact is explained by the lower content of fatty acids in the malignant tissue. Differences between spectra of healthy of mastopathically affected tissue were only small. (orig.)

  2. In vitro NMR spectroscopy of healthy, mastopathically modified and carcinomatous breast tissue samples correlated with histological findings. In-vitro-NMR-Spektroskopie an gesunden, mastopathisch veraenderten und karzinomatoes befallenen Brustdruesengewebeproben, korreliert mit histologischen Befunden

    Energy Technology Data Exchange (ETDEWEB)

    Speckter, H. (Klinik mit Poliklinik fuer Radiologie, Johannes-Gutenberg-Univ., Mainz (Germany)); Bluemich, B. (Max-Planck-Inst. fuer Polymerforschung, Mainz (Germany)); Just, M. (Klinik mit Poliklinik fuer Radiologie, Johannes-Gutenberg-Univ., Mainz (Germany)); Troemel, U. (Klinik mit Poliklinik fuer Radiologie, Johannes-Gutenberg-Univ., Mainz (Germany)); Mitze, M. (Frauenklinik der Johannes-Gutenberg-Univ., Mainz (Germany)); Thelen, M. (Frauenklinik der Johannes-Gutenberg-Univ., Mainz (Germany))

    1994-08-01

    Of 57 patients with clinically suspected mamma carcinoma 121 samples were analysed by in vitro [sup 1]H-NMR spectroscopy at 300 MHz and correlated with histological data. Within the relevant spectral region between 2.7 and 4.1 ppm strong signals were observed from fat, (phosphoryl-) choline, (phospho-) creatine, and carnitine. Furthermore, with high regularity, 8 weak, partly overlapping signals were resolved and attributed to glucose, glycine, threonine, serine, inositol, and sucrose. Their intensities were determined by an iterative fitness program. From the intensity ratios, different kinds of tissue could be distinguished based on spectroscopic criteria. Healthy or mastopathically modified tissue could be discriminated from more than 50% carcinomally affected tissue with a specificity of better than 99.5%. This fact is explained by the lower content of fatty acids in the malignant tissue. Differences between spectra of healthy of mastopathically affected tissue were only small. (orig.)

  3. Profil des cancers gynécologiques et mammaires à Yaoundé - Cameroun

    Science.gov (United States)

    Sando, Zacharie; Fouogue, Jovanny Tsuala; Fouelifack, Florent Ymele; Fouedjio, Jeanne Hortence; Mboudou, Emile Telesphore; Essame, Jean Louis Oyono

    2014-01-01

    Introduction En Afrique subsaharienne, les cancers constituent un fléau dont les caractéristiques restent à préciser. Méthodes Afin de déterminer les aspects histologiques et cliniques des cancers gynécologiques et mammaires au Cameroun, nous avons mené une étude descriptive et rétrospective sur une période de 54 mois à l'Hôpital Gynéco-Obstétrique et Pédiatrique de Yaoundé. Résultats Les 424 cas enregistrés se répartissaient ainsi: cancers du col de l'utérus: 210 cas (49.5%); du sein: 144 cas (34%); de l'ovaire: 31 cas (7.4%); de l'endomètre: 21 cas (4.9%); de la vulve: 14 cas (3.3%); du vagin: 1 cas (0.2%) et les sarcomes utérins: 3 cas (0.7%). Pour le cancer du sein, l’âge moyen au diagnostic était de 46.08±4.0 ans, 92.4% de patientes présentaient une masse (dont 60.9% localisées au quadrant supéro-externe), 76.4% étaient découverts aux stades T3 et T4, et 71.5% étaient les carcinomes canalaires. Pour les cancers du col, l’âge moyen au diagnostic était de 52.43±3.82 ans, 62.9% étaient découverts aux stades FIGO 1 et 2, et 87.6% étaient des carcinomes épidermoïdes. Pour le cancer de l'ovaire, l’âge moyen au diagnostic était de 49.0±9.31 ans, 90.3% étaient des tumeurs épithéliales et 74.2% étaient aux stades 2 et 3 (FIGO). Quant aux cancers de l'endomètre, l’âge moyen au diagnostic était de 59±14.55 ans, 90.5% étaient des adénocarcinomes. Conclusion Les principaux cancers étaient ceux du col de l'utérus et du sein. Le diagnostic étant souvent fait aux stades tardifs et par conséquent de mauvais pronostic, la prévention des cancers gynécologiques et mammaires devrait être renforcée au Cameroun. PMID:24932339

  4. Autoradiographic studies and experiments on partical synchronization of human tumors, especially mammary carcinomas, in vitro and in vivo following xenotransplantation to NU/NU mice

    International Nuclear Information System (INIS)

    Human mammary carcinomes were evaluated radiographically in vitro in the native state. Penetration dephts up to 552 ?m into the tissue were reached by the incubating medium. The labelling indices for the 3H-thymidine autoradiography lay between 1.5 and 19.3 percent. A correlation of the autoradiographic labelling indices with the findings of a simultaneously performed in vitro sensitivity test against cytostalics could not be proved. There seems to be a relation between the histomorphological tumour image and the proliferation behaviour expressed by the autoradiographic labelling index. Human mammary carcinomes were cultivated as xeno-transplant on thymus-aplastic NU/NU mice in parallel to this investigation. These heterotransplants show a remarkable correlation to the proliferation behaviour of the directly examined human tumours, after an autoradiographic in-vivo-labelling, with index values between 1.5 and 23.8 percent. This parallelism in the biological behaviour represents a further proof for the usefulness of the oncological test model of the NU/NU mouse as a carrier for human cacinomes. The application of this pre-therapeutical test model followed by determination of the synchronization behaviour of three human malignomas after xeno-transplantation onto NU/NU mice. For all three tumous an individual synchronization behaviour could be determined. Therapy attempts followed with cyclophosphonide or ionizing radiation by using the optimal cell-cycle therapy. Therefore an improvement of the therapeutical success by means of pre-therapeutical synchronization of human tumours can be reached in particular cases. (orig./MG)

  5. Radiotherapy in epithelial tumors of the parotid gland: Case presentation and literature review

    International Nuclear Information System (INIS)

    A group of 113 patients irradiated for parotid tumor was studied retrospectively. Sixty-two patients were irradiated after superficial parotidectomy or enucleation of a pleomorphic adenoma. None of them had a recurrence after 5-15 years. Sixteen patients were irradiated postoperatively after surgery for a recurrence of pleomorphic adenoma. Only one of them had developed a recurrent tumor. Thirty-five patients with a malignant parotid tumor were treated by irradiation, 22 after surgery and 13 after biopsy only. Patients with a low malignancy tumor (10/11) and adenoid cystic carcinoma (6/12) responded better than patients with a high malignancy carcinoma (2/12). A tumor larger than 4 cm, facial nerve palsy, lymph node metastasis, and inoperability indicate a poor prognosis. With high dose radiotherapy it is possible to treat inoperable tumors successfully. Adenoid cystic carcinomas can respond well to irradiation alone.43 references

  6. Fast neutron radiotherapy for advanced malignant tumors of the paranasal sinuses

    International Nuclear Information System (INIS)

    The radiotherapy of advanced and low grade tumors of the internal nose and paranasal sinuses is still a problem. The results of neutron therapy of 20 patients with advanced and low grade tumors are presented. These patients were treated between July 1977 and October 1988. The mean age of patients is 53 years. Ten patients had adenoid cystic carcinomas, three patients squamous cell carcinomas, one patient a mucinous cell carcinoma, two patients a low grade adenocarcinoma and four patients low grade sarcomas. Mean follow-up is 16 months. Local control could be achieved in eleven cases. The results show that adenoid cystic carcinomas, low grade adenocarcinomas and sarcomas benefit from neutron therapy. (orig.)

  7. Long-term prognosis of maxillary sinus malignant tumor patients treated by fast neutron radiation therapy

    International Nuclear Information System (INIS)

    From 1976 through 1990, 19 patients with maxillary sinus malignant tumor were treated with combination therapy consisting of maxillectomy and radiation of fast neutron. Fast neutron radiotherapy was performed at National Institute of Radiological Sciences. Eight patients had adenoid cystic carcinomas, three patients squamous cell carcinomas, one patient a carcinoma in pleomorphic adenoma, four patients fibrosarcomas, one patient osteosarcoma, one patient chondrosarcoma and one patient rhabdomyosarcoma. Fast neutron therapy after/before surgery was effective in fresh cases with T2-3N0M0 adenoid cystic carcinomas and sarcomas (except for fibrosarcoma). Nine patients were alive more than three years after treatment. And serious complications of fast neutron radiation therapy appeared in six of these nine patients. Visual impairment of opposite side occurred in four patients. Bone necrosis occured in one patient and brain dysfunction in one patient. (author)

  8. THE DYNAMIC OF CYTOKINE PROFILE IN PATIENTS WITH UPPER RESPIRATORY TRACT INFLAMMATORY DISEASES OF DIFFERENT NOSOLOGY

    Directory of Open Access Journals (Sweden)

    Nesterenko AM

    2012-12-01

    Full Text Available The level of some cytokines in the serum of patients with inflammatory diseases of URT of different nosology: pharyngitis, tonsillitis, adenoiditis, polyposis was studied. The levels of IL - 8, IL – 10 and IFN – ? were determined. The changes in levels and ratios of cytokines was studied in course of inflammatory process. It was found that in course of inflammatory processes in URT, regardless of nosology form, a reliable increase in levels of IL – 8, IL – 10 is observed. The levels of IFN - ? were higher compared to control values, but differences were insignificant. It was established that a disbalance of IL - 10 / IFN – ? ratio occurs in course of inflammatory processes in URT. The increase in IL-10 level with simultaneous reduction in IFN - ? was more profound in adenoiditis and polyposis patients compared with pharyngitis and tonsillitis groups.

  9. Oral epithelial cells are susceptible to cell-free and cell-associated HIV-1 infection in vitro

    International Nuclear Information System (INIS)

    Epithelial cells lining the oral cavity are exposed to HIV-1 through breast-feeding and oral-genital contact. Genital secretions and breast milk of HIV-1-infected subjects contain both cell-free and cell-associated virus. To determine if oral epithelial cells can be infected with HIV-1 we exposed gingival keratinocytes and adenoid epithelial cells to cell-free virus and HIV-1-infected peripheral blood mononuclear cells and monocytes. Using primary isolates we determined that gingival keratinocytes are susceptible to HIV-1 infection via cell-free CD4-independent infection only. R5 but not X4 viral strains were capable of infecting the keratinocytes. Further, infected cells were able to release infectious virus. In addition, primary epithelial cells isolated from adenoids were also susceptible to infection; both cell-free and cell-associated virus infected these cells. These data have potential implications in the transmission of HIV-1 in the oral cavity

  10. Coblation adenoidectomy our experience

    Directory of Open Access Journals (Sweden)

    Balasubramanian Thiagarajan

    2014-03-01

    Full Text Available Aim of our study is to compare the efficacy and safety of coblation adenoidectomy versus conventional cold steel adenoidectomy. The study design included 40 children between age groups 4 – 8. Twenty of these children underwent coblation adenoidectomy while the other group of 20 underwent conventional cold steel adenoidectomy. The parameters taken into consideration for comparison included Post operative pain, operating time, intraoperative bleeding and presence of residual adenoid tissue 6 weeks after surgery. In this study the coblation group demonstrated less post operative pain, less intraoperative bleeding and more complete removal of adenoid tissue. Operative time was found to be significantly higher in coblation group when compared to conventional cold steel adenoidectomy group.

  11. Endoscopic Adenoidectomy with Microdebrider

    OpenAIRE

    Somani, S. S.; Naik, C. S.; Bangad, S. V.

    2010-01-01

    To describe endoscopic power assisted adenoidectomy and review the experience with the procedure demonstrating its safety and efficacy. Prospective study of 44 patients aged between 7 to 15 years undergoing power assisted adenoidectomy between Jan 2004 and July 2006. Tertiary care private teaching hospital. Forty four consecutive children with adenoid hypertrophy undergoing power assisted adenoidectomy. Therapeutic endoscopic adenoidectomy using microdebrider. Operative time, blood loss, com...

  12. Regulation of production of mucosal antibody to pneumococcal protein antigens by T-cell-derived gamma interferon and interleukin-10 in children

    OpenAIRE

    Zhang, Q.; Bernatoniene, J.; Bagrade, L.; Paton, J. C.; Mitchell, T. J.; Hammerschmidt, S.; Nunez, D. A.; Finn, A.

    2006-01-01

    Nasopharyngeal tonsils (adenoids) are part of human nasopharynx-associated lymphoid tissue, which may play an important role in local defense against pneumococci. Recent studies with animals have suggested that several pneumococcal proteins, including CbpA and pneumolysin (Ply), may be vaccine candidates. Our recent data obtained with children suggest that antibodies to these proteins may protect against carriage. This study was performed to investigate the regulation of the T-cell-dependent ...

  13. Minor salivary gland tumors in a south American population

    OpenAIRE

    Conceição Barros Adna; Gurgel Silva Araújo Clarissa; Gomes Caymmi Mário; Agra Gonçalves Marcelo Ivan; Kruschewsky de Souza Leonardo; Dos Santos Nunes Jean

    2010-01-01

    Background: Salivary gland tumors are uncommon. This study aimed to investigate both clinical and epidemiological aspects of minor salivary gland tumors in a Brazilian population. Methods: From 1976 to 2007, data obtained from clinical records and histological diagnoses were reviewed according to the WHO. Results: A total of 217 MSGTs were identified. Pleomorphic adenomas (83%) and adenoid cystic carcinomas (28.8%) were the most frequent ones. The mean age of patients with benign and ma...

  14. Structural and Immunological Characteristics of Chronically Inflamed Adenotonsillar Tissue in Childhood

    OpenAIRE

    Passa?li, Desiderio; Damiani, Valerio; Passa?li, Giulio Cesare; Passa?li, Francesco Maria; Boccazzi, Antonio; Bellussi, Luisa

    2004-01-01

    Recurrent or chronic adenotonsillar infections mainly affect children and frequently involve otherwise healthy subjects. Therefore, having excluded systemic immunological deficiencies, this disease may be due to a local dysfunction of the epithelial structures at either the rhino or oropharyngeal level. The aim of the present investigation was to analyze structural and immunological aspects of tonsils and adenoids in subjects who underwent adenotonsillectomy because of recurrent inflammatory ...

  15. Management of difficult airway in intratracheal tumor surgery

    OpenAIRE

    Agarwal Surendra K; Tewari Prabhat; Tyagi Isha; Goyal Amit; Syal Rajan

    2005-01-01

    Abstract Background Tracheal malignancies are usual victim of delay in diagnosis by virtue of their symptoms resembling asthma. Sometimes delayed diagnosis may lead to almost total airway obstruction. For difficult airways, not leaving any possibility of manipulation into neck region or endoscopic intervention, femorofemoral cardiopulmonary bypass can be a promising approach. Case Presentation We are presenting a case of tracheal adenoid cystic carcinoma (cylindroma) occupying about 90% of th...

  16. The correlation between tonsil size and academic performance is not a direct one, but the results of various factors

    OpenAIRE

    Kargoshaie, Aa; Najafi, M.; Akhlaghi, M.; Khazraie, Hr; Hekmatdoost, A.

    2009-01-01

    Chronic upper airway obstruction most often occurs when both tonsils and adenoid are enlarged but may occur when either is enlarged. Obstructive sleep syndrome in young children has been reported to be associated with an adverse effect on learning and academic performance. The aim of this study was to evaluate the effect of relative size of the tonsil on academic performance in 4th grade school children. In 320 children, physical examination to determine the size of tonsils was performed by t...

  17. Adenotonsillar disease.

    Science.gov (United States)

    Zautner, Andreas E

    2012-05-01

    Adenotonsillar disease (adenoiditis and recurrent tonsillitis) is a prevalent otolaryngologic disorder aetiologically based on chronic inflammation triggered by a persistent bacterial infection. These bacteria, mostly Staphylococcus aureus, Haemophilus sp., and Streptococcus sp., persist predominantly intracellular and within mucosal biofilms. The recurrent or chronic inflammation of the adenoids and faucial tonsils leads to chronic activation of the cell-mediated and humoral immune response, resulting in hypertrophy of the lymphoid tonsillar tissue. This hypertrophic tissue is the cause for the prominent clinical symptoms: obstruction of the upper airways, snoring, and sleep apnea for adenoiditis or sore throat, dysphagia and halitosis for recurrent tonsillitis. Treatment strategies should target the persisting bacteria within their biofilm or intracellular shelter. Macrolide antibiotics like clarithromycin are able to modulate the immune system and to interfere in bacterial signaling within biofilms. Clindamycin, quinupristin-dalfopristin, and oritavancin are intracellular high active compounds. Surgical removal of the hypertrophic tissue by modern procedures like laser tonsil ablation, eliminates not only a mechanical obstacle of the airways, it removes also the basis for the aetiologic cause, the "biofilm carrier". This review summarizes the role of bacterial persistence in mucosal biofilms for the aetiology, diagnosis and treatment of adenotonsillar disease and relevant patents. PMID:22452646

  18. Intravoxel incoherent motion MRI: emerging applications for nasopharyngeal carcinoma at the primary site

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Shui-xing; Jia, Qian-jun; Liang, Chang-hong; Chen, Wen-bo; Qiu, Qian-hui; Li, He [Guangdong Academy of Medical Sciences/Guangdong General Hospital, Department of Radiology, Guangzhou, Guangdong Prov. (China); Zhang, Zhong-ping [Applied Science Lab, Guangzhou, Guangdong Prov. (China)

    2014-08-15

    We compared pure molecular diffusion (D), perfusion-related diffusion (D*), perfusion fraction (f) and apparent diffusion coefficient (ADC) based on intravoxel incoherent motion (IVIM) theory in patients with nasopharyngeal carcinoma (NPC). Sixty-five consecutive patients (48 men) with suspected NPC were examined using a 3.0-T MR system. Diffusion-weighted imaging (DWI) was performed with 13 b values (range, 0-800 s/mm{sup 2}). We regarded the result of endoscopy and biopsy as the gold standard for detection. D, D* and f were compared between patients with primary NPC and enlarged adenoids. IVIM DWI was successful in 37 of 40 NPC and 23 of 25 enlarged adenoids cases. D (P = 0.001) and f (P < 0.0001) were significantly lower in patients with NPC than in patients with enlarged adenoids, whereas D* was significantly higher (P < 0.0001). However, the ADC was not significantly different between the two groups (P > 0.05). The area under the ROC curve (AUC) for D was 0.849 and was significantly larger than that for ADC (P < 0.05). IVIM DWI is a feasible technique for investigating primary NPC. D was significantly decreased in primary NPC, and increased D* reflected increased blood vessel generation and parenchymal perfusion in primary NPC. (orig.)

  19. Maspin and MCM2 immunoprofiling in salivary gland carcinomas

    Directory of Open Access Journals (Sweden)

    Helmy Iman M

    2011-09-01

    Full Text Available Abstract Background The pathogenesis of salivary gland carcinomas is very complex and prognostic markers are difficult to find in these carcinomas of which the different subtypes have varying malignant potential. The study was conducted to examine the cellular distribution of maspin and MCM2 in salivary gland carcinomas and their value to predict lymph node metastasis. Materials and methods Fifty three paraffin blocks of different lesions (15 muco-epidermoid carcinoma, 14 adenoid cystic carcinoma, 3 epi-myoepithelial carcinoma, 5 salivary duct carcinoma, 5 malignant pleomorphic adenoma, 6 polymorphous low grade adenocarcinoma and 5 acinic cell carcinoma were prepared for immunohistochemical staining with maspin and MCM2 antibodies. ANOVA and Pearson correlation tests were used for the statistical analysis of the results. Results All salivary gland carcinomas express maspin and MCM2 with variable cellular localization. There was a significant difference in the expression of each antibody between mucoepidermoid carcinoma, adenoid cystic carcinoma and polymorphous low grade adenocarcinoma. No association was found between examined markers and lymph node metastasis. Conclusions Salivary gland carcinomas express maspin and MCM2 with variable levels and cellular localization, consisting important markers of biological behavior in these tumors. The level of MCM2 expression can be used in the differential diagnosis of adenoid cystic carcinoma and polymorphous low grade adenocarcinoma. Further study with large sample size is recommended to assess their value in prediction of lymph node metastasis.

  20. Continuing occurrence of thyroid carcinoma after irradiation to the neck in infancy and childhood

    International Nuclear Information System (INIS)

    To determine whether the occurrence of x-ray-induced thyroid carcinoma has not declined, we examined 100 patients with a history of irradiation to the neck area. Irradiation had been given to tonsils (42 percent), adenoids (10 percent), tonsils and adenoids (7 percent) and thymus (30 percent), for acne (7 percent), and for various other reasons (7 percent). Operation was recommended to 18 of 26 patients with palpable abnormalities and 15 were operated upon; we found seven carcinomas, and eight benign lesions. Five of six carcinomas had invasive characteristics, with or without metastases, five of seven were multifocal, and six of seven had a follicular component. Of seven patients irradiated to both tonsils and adenoids and thus receiving higher radiation exposure, two had carcinoma, suggesting a dose relation. The overall 7 percent prevalence of carcinoma in unselected patients with a history of irradiation to the neck area is higher than expected and implies a continuing important public-health problem, at least in the Chicago area. (auth)

  1. Acetylcysteine Rinse in Reducing Saliva Thickness and Mucositis in Patients With Head and Neck Cancer Undergoing Radiation Therapy

    Science.gov (United States)

    2014-12-03

    Mucositis; Oral Complications; Recurrent Adenoid Cystic Carcinoma of the Oral Cavity; Recurrent Basal Cell Carcinoma of the Lip; Recurrent Lymphoepithelioma of the Nasopharynx; Recurrent Lymphoepithelioma of the Oropharynx; Recurrent Mucoepidermoid Carcinoma of the Oral Cavity; Recurrent Salivary Gland Cancer; Recurrent Squamous Cell Carcinoma of the Larynx; Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity; Recurrent Squamous Cell Carcinoma of the Nasopharynx; Recurrent Squamous Cell Carcinoma of the Oropharynx; Recurrent Verrucous Carcinoma of the Larynx; Recurrent Verrucous Carcinoma of the Oral Cavity; Stage I Adenoid Cystic Carcinoma of the Oral Cavity; Stage I Basal Cell Carcinoma of the Lip; Stage I Lymphoepithelioma of the Nasopharynx; Stage I Lymphoepithelioma of the Oropharynx; Stage I Mucoepidermoid Carcinoma of the Oral Cavity; Stage I Salivary Gland Cancer; Stage I Squamous Cell Carcinoma of the Larynx; Stage I Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage I Squamous Cell Carcinoma of the Nasopharynx; Stage I Squamous Cell Carcinoma of the Oropharynx; Stage I Verrucous Carcinoma of the Larynx; Stage I Verrucous Carcinoma of the Oral Cavity; Stage II Adenoid Cystic Carcinoma of the Oral Cavity; Stage II Basal Cell Carcinoma of the Lip; Stage II Lymphoepithelioma of the Nasopharynx; Stage II Lymphoepithelioma of the Oropharynx; Stage II Mucoepidermoid Carcinoma of the Oral Cavity; Stage II Salivary Gland Cancer; Stage II Squamous Cell Carcinoma of the Larynx; Stage II Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage II Squamous Cell Carcinoma of the Nasopharynx; Stage II Squamous Cell Carcinoma of the Oropharynx; Stage II Verrucous Carcinoma of the Larynx; Stage II Verrucous Carcinoma of the Oral Cavity; Stage III Adenoid Cystic Carcinoma of the Oral Cavity; Stage III Basal Cell Carcinoma of the Lip; Stage III Lymphoepithelioma of the Nasopharynx; Stage III Lymphoepithelioma of the Oropharynx; Stage III Mucoepidermoid Carcinoma of the Oral Cavity; Stage III Salivary Gland Cancer; Stage III Squamous Cell Carcinoma of the Larynx; Stage III Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage III Squamous Cell Carcinoma of the Nasopharynx; Stage III Squamous Cell Carcinoma of the Oropharynx; Stage III Verrucous Carcinoma of the Larynx; Stage III Verrucous Carcinoma of the Oral Cavity; Stage IV Lymphoepithelioma of the Nasopharynx; Stage IV Squamous Cell Carcinoma of the Nasopharynx; Stage IVA Adenoid Cystic Carcinoma of the Oral Cavity; Stage IVA Basal Cell Carcinoma of the Lip; Stage IVA Lymphoepithelioma of the Oropharynx; Stage IVA Mucoepidermoid Carcinoma of the Oral Cavity; Stage IVA Salivary Gland Cancer; Stage IVA Squamous Cell Carcinoma of the Larynx; Stage IVA Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage IVA Squamous Cell Carcinoma of the Oropharynx; Stage IVA Verrucous Carcinoma of the Larynx; Stage IVA Verrucous Carcinoma of the Oral Cavity; Stage IVB Adenoid Cystic Carcinoma of the Oral Cavity; Stage IVB Basal Cell Carcinoma of the Lip; Stage IVB Lymphoepithelioma of the Oropharynx; Stage IVB Mucoepidermoid Carcinoma of the Oral Cavity; Stage IVB Salivary Gland Cancer; Stage IVB Squamous Cell Carcinoma of the Larynx; Stage IVB Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage IVB Squamous Cell Carcinoma of the Oropharynx; Stage IVB Verrucous Carcinoma of the Larynx; Stage IVB Verrucous Carcinoma of the Oral Cavity; Stage IVC Adenoid Cystic Carcinoma of the Oral Cavity; Stage IVC Basal Cell Carcinoma of the Lip; Stage IVC Lymphoepithelioma of the Oropharynx; Stage IVC Mucoepidermoid Carcinoma of the Oral Cavity; Stage IVC Salivary Gland Cancer; Stage IVC Squamous Cell Carcinoma of the Larynx; Stage IVC Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage IVC Squamous Cell Carcinoma of the Oropharynx; Stage IVC Verrucous Carcinoma of the Larynx; Stage IVC Verrucous Carcinoma of the Oral Cavity; Tongue Cancer

  2. WholeBbody Positron-Emission-Tomography (WB-PET) in oncology; Ganzkoerper-Positronen-Emissions-Tomographie (GK-PET) in der Onkologie

    Energy Technology Data Exchange (ETDEWEB)

    Feine, U. [Nuklearmedizinische Abt., Tuebingen Univ. (Germany); Lietzenmayer, R. [Nuklearmedizinische Abt., Tuebingen Univ. (Germany); Mueller-Schauenburg, W. [Nuklearmedizinische Abt., Tuebingen Univ. (Germany); Geiger, L. [Nuklearmedizinische Abt., Tuebingen Univ. (Germany); Hanke, J.P. [Nuklearmedizinische Abt., Tuebingen Univ. (Germany); Weisser, G. [Nuklearmedizinische Abt., Tuebingen Univ. (Germany); Woehrle, H. [Nuklearmedizinische Abt., Tuebingen Univ. (Germany)

    1996-02-01

    The new generation of high sensitive PET-Scanners with an FOV of about 15 cm allows to recognize with high sensitivity and good spezificity malign tumors and their metastases with 18F-FDG in a Whole-Body-Scan in 35 to 50 min scan time. 357 FDG-WB-PET-Scans have been performed in Tuebingen during 1 1/2 years since January 1994 in tumor patients and have been compared and evaluated to the results of other imaging methods performed in the same time together with clinics and in follow-up. In 4 groups of tumors - Melanoma - malign Lymphoma - Breast Cancer - Thyroid Cancer - and a fifth group of 24 various types of malign tumors we found a sensitivity of 88%, a specificity of 80% and an accuracy of 90%. Foci smaller than 6-8 mm diametre - mostly lung metastases or lymphomas - and also tumors of low malignancy such as 131l-trapping Tyroid Carcinomas and Ganglioneuroblastomas have been found false negative. Flase positive we found inflammated lymph nodes, abscesses and also benign thyroid adenomas. This high sensitivity makes 18F-FDG-WB-PET an important method for tumor searching and diagnosis of tumor spreading, esp. for primary and secondary staging in the future, but also as the unique imaging method which allows determination of resting tumor vitality after therapy. Further multi-center studies will be necessary before this method can be introduced to routine, that also is limited by the high costs of the procedure. (orig.) [Deutsch] Die neue Generation der hochaufloesenden PET-Scanner mit einer axialen Feldbreite von 15 cm ermoeglicht es, mit hoher Sensitivitaet und guter Spezifitaet maligne Tumoren und ihre Metastasen mit 18F-Fluordeoxyglukose in einem Ganzkoerper-Scan mit 35-50 min Scan-Zeit zu erkennen. 357 FDG-GK-PET Scans wurden in 1 1/2 Jahren ab Januar 1994 in Tuebingen bei Tumor-Patienten durchgefuehrt und mit gleichzeitig erstellten anderen bildgebenden Verfahren zusammen mit der Klinik und im Follow Up ausgewertet. Bei den vier Tumorgruppen Melanom - Malignes Lymphom - Mamma-Carcinom - Schilddruesen-Carcinom und einer fuenften Gruppe, in der 24 verschiedene maligne Tumoren untersucht worden waren, ergaben sich eine Sensitivitaet von 88%, eine Spezifitaet von 80% und eine Treffsicherheit von 90%. Falsch negativ waren Herde <6-8 mm im Durchmesser, meist Lungenmetastasen oder Lymphome, sowie niedrig maligne Tumoren wie 131J-speichernde Schilddruesen-Carcinome und auch Ganglioneuroblastome. Falsch positiv ergaben sich entzuendliche Lymphknoten, Abszesse, aber auch benigne Schilddruesenadenome. Bei der gefundenen hohen Sensitivitaet duerfte 18FDG-GK-PET in Zukunft ein wertvolles Verfahren zur Tumorsuche und Tumorausbreitungsdiagnostik sowie fuer das primaere und sekundaere Staging sein, aber auch zur Bestimmung der Restaktivitaet in Tumoren nach Therapie als einziges bildgebendes Verfahren eine Aussage ermoeglichen. Weitere Multizenterstudien sind notwendig, bevor das Verfahren in die Routine eingefuehrt werden kann, dem allerdings bisher auch die hohen Kosten noch entgegenstehen. (orig.)

  3. Evaluación del adenoidismo en los niños: imagen endoscópica

    Directory of Open Access Journals (Sweden)

    Calogero Grillo

    2000-12-01

    Full Text Available El adenoidismo es un síndrome complejo cuya causa principal se identifica generalmente con la hiperplasia de las amígdalas y la nasofaringe, pero abarca también diversos aparatos y estructuras que aún cuando se encuentran lejos de la nasofaringe, se relacionan funcionalmente con ella. Las afecciones locales caracterizadas por obstrucción nasal y rinorrea a menudo purulentas, se asocian con enfermedades de los senos (sinusitis, con afecciones del oído (otalgia, otorrea serosa o serosa-purulenta o ambas cosas, así como hipoacusia, con enfermedades de la laringe (disfonía y afonía, con afecciones de las vías respiratorias inferiores (tos, bronquitis recurrente, con enfermedades de los huesos de la cara (paladar ojival, deficiencia de la oclusión dental, así como con afecciones sistémicas (apnea del sueño, OSAS. La endoscopia de fibra óptica es la prueba de selección para valorar la calidad y la extensión de la hipertrofia de las adenoidesAdenoidism is a complex syndrome whose main cause is generally identified with hyperplasia of the tonsils and nasopharynx, but it also involves diverse systems and structures that even when they are not close to the nasopharynx are functionally related to it. The local affections characterized by usually purulent nasal obstruction and rhinorrea are associated with diseases of the sinuses (sinusitis, with affections of the ear (otalgia, serous or serouspurulent otorrhoea or both, as well as hypoacusia, with larynx diseases (dysphonia and aphonia, with affections of the lower airways (cough, recurrent bronchitis, with face bone diseases (ogival palate, deficiency of dental oclussion, as well as systemic affections (sleep apnea, OSAS. The optic fibre endoscopy is the selection test to asses the quality and extension of adenoids hypertrophy

  4. Evaluación del adenoidismo en los niños: imagen endoscópica

    Scientific Electronic Library Online (English)

    Calogero, Grillo; Vittorio, Giardina; Alessandro, La Boria; Enza, Di Fazio; Simona, Ficarra; Ignazio, La Mantia.

    2000-12-01

    Full Text Available SciELO Cuba | Language: Spanish Abstract in spanish El adenoidismo es un síndrome complejo cuya causa principal se identifica generalmente con la hiperplasia de las amígdalas y la nasofaringe, pero abarca también diversos aparatos y estructuras que aún cuando se encuentran lejos de la nasofaringe, se relacionan funcionalmente con ella. Las afecciones [...] locales caracterizadas por obstrucción nasal y rinorrea a menudo purulentas, se asocian con enfermedades de los senos (sinusitis), con afecciones del oído (otalgia, otorrea serosa o serosa-purulenta o ambas cosas, así como hipoacusia), con enfermedades de la laringe (disfonía y afonía), con afecciones de las vías respiratorias inferiores (tos, bronquitis recurrente), con enfermedades de los huesos de la cara (paladar ojival, deficiencia de la oclusión dental), así como con afecciones sistémicas (apnea del sueño, OSAS). La endoscopia de fibra óptica es la prueba de selección para valorar la calidad y la extensión de la hipertrofia de las adenoides Abstract in english Adenoidism is a complex syndrome whose main cause is generally identified with hyperplasia of the tonsils and nasopharynx, but it also involves diverse systems and structures that even when they are not close to the nasopharynx are functionally related to it. The local affections characterized by us [...] ually purulent nasal obstruction and rhinorrea are associated with diseases of the sinuses (sinusitis), with affections of the ear (otalgia, serous or serouspurulent otorrhoea or both, as well as hypoacusia), with larynx diseases (dysphonia and aphonia), with affections of the lower airways (cough, recurrent bronchitis), with face bone diseases (ogival palate, deficiency of dental oclussion), as well as systemic affections (sleep apnea, OSAS). The optic fibre endoscopy is the selection test to asses the quality and extension of adenoids hypertrophy

  5. Parotid gland tumours in a West Indian population: Comparison to world trends.

    Science.gov (United States)

    Ramdass, Michael J; Maharaj, Khemanand; Mooteeram, Justin; Dwarika, Wendell; Tilluckdharry, Clyde; Barrow, Shaheeba

    2015-01-01

    The epidemiology of parotid gland tumours in Trinidad and Tobago and the wider Caribbean is currently unknown. Therefore, an analysis of the pathological records was conducted to determine the pattern of this disease in Trinidad and Tobago. A retrospective analysis was conducted on all parotid gland tumours and the demographic and histological data were analysed. Data from 60 cases were collected over a period of 8 years (October, 2003 to February, 2012), including 56 primary and 4 secondary tumours (1 basal cell carcinoma and 3 metastatic tumours). The patients included 31 men and 29 women, with a mean age of 48.7 years and an age range of 21-73 years (peak age, 51-60 years). The surgical interventions included 53 superficial parotidectomies, 6 radical parotidectomies and 1 biopsy. Of the 56 primary tumours, 41 were benign [34 pleomorphic adenomas and 7 Warthin's tumours (adenolymphomas)], accounting for 73.2% of the cases. The malignant lesions included 6 squamous cell carcinomas, 3 mucoepidermoid carcinomas, 2 acinic cell carcinomas, 2 adenoid cystic carcinomas, 1 anaplastic carcinoma and 1 papillary carcinoma, accounting for 26.8% of the total cases, without any age predominance. The pattern of disease distribution was similar to that indicated by worldwide data, with benign primary lesions accounting for ~80% of the cases (pleomorphic adenomas, 80% and Warthin's tumours, 20%). The most common carcinomas were mucoepidermoid and adenoid cystic types, as indicated by worldwide data; however, in our series, squamous cell carcinoma was the most common type, followed by mucoepidermoid, acinic cell and adenoid cystic carcinomas. The present study will hopefully provide useful information on parotid pathology in Trinidad and Tobago and encourage further research in this field. PMID:25469289

  6. Is routine pathological examination required in South African children undergoing adenotonsillectomy?

    Scientific Electronic Library Online (English)

    Anton C, van Lierop; C A J, Prescott.

    2009-11-01

    Full Text Available SciELO South Africa | Language: English Abstract in english OBJECTIVE: We aimed to determine the incidence of abnormal pathological findings in the tonsils and/or adenoids of children undergoing tonsillectomy and/or adenoidectomy, and the incidence of tuberculosis of the tonsils and adenoids; suggest criteria to identify children at risk for adenotonsillar t [...] uberculosis; and investigate the association between HIV and adenotonsillar abnormality, the cost-effectiveness of routine pathological examination of adenotonsillectomy specimens, and criteria to decide which specimens to send for histological examination. METHODS: We undertook an 8-month prospective study on all children (>12 years) undergoing consecutive tonsillectomy or adenotonsillectomy (T&A) at Red Cross War Memorial Children's Hospital. Patients were assessed pre-operatively and tonsil sizes graded pre- and intra-operatively. Blood was taken for HIV testing, and all tonsils and adenoids were examined histologically. A cost-benefit analysis was done to determine the cost-effectiveness of adenotonsillectomy routine pathology. RESULTS: A total of 344 tonsils were analysed from 172 children (102 boys, 70 girls); 1 patient had nasopharyngeal tuberculosis, and 1 lymphoma of the tonsils; 13 (7.6%) patients had clinically asymmetrically enlarged tonsils but no significant abnormal pathological finding. The average cost of detecting a clinically significant abnormality was R22 744 (R45 488 ÷ 2 abnormalities). CONCLUSIONS: The following criteria could improve cost-effectiveness of pathological examination of adenotonsillectomy specimens: positive tuberculosis contact at home, systemic symptoms of fever and weight loss, cervical lymphadenopathy >3 cm, suspicious nasopharyngeal appearance, HIV-positive patient, rapid tonsillar enlargement or significant tonsillar asymmetry. On our evidence, routine pathological investigation for South African children does not seem to be justified.

  7. Clinical application of a new 0.63- to 0.65-?m pulse diode laser in treating ear, throat, and nose diseases in adults and children

    Science.gov (United States)

    Nasedkin, Alexy N.; Pletnev, A. S.

    2001-04-01

    An investigation was made of applying a pulsed diode laser emitting at the wavelengths of 0.63 to 0.65 micrometers to treat various otolaryngological diseases, such as rhinosinusitis, acute rhinitis, vasomotor rhinitis, allergic rhinitis, the illness of the lymphoid ring, adenoiditis, chronic tonsillitis, pharyngitis, and catarrhal and suppurative otitis. The therapeutic effect produced by the pulsed diode laser was compared with that of conventional therapeutic lasers. It was found that the pulsed low-intensity laser radiation in the red spectrum region offered a number of advantages over conventional laser therapeutic techniques.

  8. Situational Awareness: Regulation of the Myb Transcription Factor in Differentiation, the Cell Cycle and Oncogenesis

    Directory of Open Access Journals (Sweden)

    Olivia L. George

    2014-10-01

    Full Text Available This review summarizes the mechanisms that control the activity of the c-Myb transcription factor in normal cells and tumors, and discusses how c-Myb plays a role in the regulation of the cell cycle. Oncogenic versions of c-Myb contribute to the development of leukemias and solid tumors such as adenoid cystic carcinoma, breast cancer and colon cancer. The activity and specificity of the c-Myb protein seems to be controlled through changes in protein-protein interactions, so understanding how it is regulated could lead to the development of novel therapeutic strategies.

  9. Situational awareness: regulation of the myb transcription factor in differentiation, the cell cycle and oncogenesis.

    Science.gov (United States)

    George, Olivia L; Ness, Scott A

    2014-01-01

    This review summarizes the mechanisms that control the activity of the c-Myb transcription factor in normal cells and tumors, and discusses how c-Myb plays a role in the regulation of the cell cycle. Oncogenic versions of c-Myb contribute to the development of leukemias and solid tumors such as adenoid cystic carcinoma, breast cancer and colon cancer. The activity and specificity of the c-Myb protein seems to be controlled through changes in protein-protein interactions, so understanding how it is regulated could lead to the development of novel therapeutic strategies. PMID:25279451

  10. Situational Awareness: Regulation of the Myb Transcription Factor in Differentiation, the Cell Cycle and Oncogenesis

    OpenAIRE

    George, Olivia L.; Ness, Scott A.

    2014-01-01

    This review summarizes the mechanisms that control the activity of the c-Myb transcription factor in normal cells and tumors, and discusses how c-Myb plays a role in the regulation of the cell cycle. Oncogenic versions of c-Myb contribute to the development of leukemias and solid tumors such as adenoid cystic carcinoma, breast cancer and colon cancer. The activity and specificity of the c-Myb protein seems to be controlled through changes in protein-protein interactions, so understanding how ...

  11. Seizures-like symptoms in an African child with life-threatening severe upper respiratory tract obstruction

    Directory of Open Access Journals (Sweden)

    Marco Zaffanello

    2015-01-01

    Full Text Available Obstructive sleep apneas are characterized by episodes of complete or partial upper airway obstruction during sleep. Symptoms and signs are associated with sleep-related breathing disorders. Sometimes it can be clinically difficult to distinguish abnormal events related to sleep disorders from seizures. We report herein the case of a child with seizures-like symptoms during sleep. Epilepsy was excluded and symptomatology was referred to life-threatening upper respiratory obstruction from tonsils and adenoids hypertrophy that required persistent intubation before surgical removal.

  12. Identificación de Colágeno I y III con Picrosirius Red/ Polarización en el Estroma de Tumores Salivales / Identification of Type I and III Collagen by Picrosirius Red/Polarization of Tumoral Salivary Stroma

    Scientific Electronic Library Online (English)

    Maria Elena, Samar; Rodolfo Esteban, Ávila; Onell Gabriela, Asis; Ismael, Fonseca; Alberto, Corball.

    2012-04-01

    Full Text Available El estroma juega un rol importante en los procesos tumorales de invasión y metástasis. Las fibras de colágeno tipo I son el principal componente estructural del estroma en distintos tumores. Sin embargo, hay muy pocos estudios en los tumores de glándulas salivales. Basándonos en estos antecedentes e [...] l objetivo de la presente comunicación fue estudiar las características del colágeno con Picrosirius red/polarización en tumores benignos y malignos de glándulas salivales para evaluar su posible rol en los mecanismos de progresión tumoral. Cortes histológicos de adenoma pleomórfico, carcinoma adenoide quístico y carcinoma epitelial mioepitelial se colorearon con H/E y Picrosirius red y se examinaron con microscopio de polarización. La birrefringencia del colágeno con Picrosirius/polarización resultó diferente en el estroma de los tumores malignos (carcinoma adenoide quístico y carcinoma epitelial mioepitelial), con predominio de colágeno I, en comparación con el tumor benigno (adenoma pleomórfico), con predominio de colágeno III. El diferente perfil de coloración en las fibras colágenas producidas en el estroma de los tumores analizados podría relacionarse con diferentes mecanismos de expansión tumoral, los que fueron poco estudiados en los tumores de glándulas salivales. Más estudios son necesarios para obtener resultados más concluyentes que contribuyan al diagnóstico, pronóstico y tratamiento. Abstract in english The stroma plays an important rol in tumoral invasion and metastasis. Type I collagen is the main structural component of the stroma in several tumors. However, there are few studies on salivary gland tumors. Based on this background the objective of the present communication was to study collagen c [...] haracteristics with picrosirius red/polarization on malignant and benign tumors of salivary glands to evaluate its posible rol in the tumoral progression mechanism. Histological sections of pleomorphic adenoma, adenoid cystic carcinoma and epithelial/myoepithelial carcinoma were stained with H/E and picrosirius red and were studied with polarization microscope. Collagen birefringence with Picrosirius/polarization was different in the malignant tumor stroma (adenoid cystic carcinoma and epithelialmyoepithelial carcinoma), with predominance of type I collagen, compared with a benign tumor (pleomorphic adenoma), with predominance of type III collagen. The different staining profile in collagen fibers produced in the benign and malignant stroma tumors analized could be related with different tumoral expansion mechanism, which were scarce studied on the salivary glands tumors. More studies are needed to obtain more conclusive results to contribute to diagnosis, prognosis and treatment.

  13. Hyaline globules in fine-needle aspiration smears of salivary gland neoplasms.

    Science.gov (United States)

    Gupta, Mayank; Bindra, Mandeep Singh

    2015-01-01

    Most salivary gland neoplasms can be accurately diagnosed on fine-needle aspiration cytology. Few cases present with overlapping cytomorphological features, so accurate distinction in these cases may be difficult. We describe a case of pleomorphic adenoma that had a close resemblance to adenoid cystic carcinoma on smears due to presence of numerous hyaline globules and bare nuclei. Careful analysis of cellular details along with corroborative clinical evidence clinched the correct diagnosis. This article discusses cytological features of salivary gland tumours in which hyaline globules can be seen on smears. PMID:25750224

  14. The results of combined therapy malignant neoplasms of maxillary sinus at Oncology Center in Poznan

    International Nuclear Information System (INIS)

    Between 1985-1989 22 patients with malignant neoplasma maxillary sinus have been treated. At the first stage the surgical resection of maxilla was performed. Most of the patients (77%) had histopathological diagnosis of carcinoma planoepitheliale, 13% carcinoma solidum and 4% carcinoma adenoides cysticum. All patients had adjuvant therapy by Co-60 irradiation. Single fraction dose of 2 Gy/T 5 times a week up to total dose of 60-70 Gy/T has been applied. In the follow-up period of minimum 36 months the free-symptoms survival rate of 18%. (author)

  15. Unilateral expiratory airflow obstruction during forced exhalation.

    Science.gov (United States)

    Hatipoglu, Umur; Laghi, Franco; Cattapan, Steven E; Chandrasekhar, Arcot J

    2002-06-01

    We present a case of unilateral airflow obstruction during forced exhalations. The patient presented with episodic dyspnea and wheezing, particularly when he lay in the right lateral decubitus position. Spirometry revealed symmetric, marked reductions in forced expiratory volume in the first second and forced vital capacity values, while plethysmography demonstrated a near-normal total lung capacity. Bronchoscopy revealed a polypoid lesion in the right main bronchus, of which biopsy specimens demonstrated adenoid cystic carcinoma. Following a right pneumonectomy, total lung capacity was markedly reduced; interestingly, however, spirometry was essentially unchanged. This case is an elegant illustration of the effects of respiratory maneuvers and body position on airway caliber. PMID:12036440

  16. Mucoepidermoid carcinoma of the lung: a case report

    OpenAIRE

    Ishibashi Kei; Hayashi Satoshi; Sato Kazuhiro; Matsuda Yoshinari; Kitada Masahiro; Miyokawa Naoyuki; Sasajima Tadahiro

    2011-01-01

    Abstract Mucoepidermoid carcinoma of the lung (MEC) is a tumor of low malignant potential of bronchial gland origin. MEC and adenoid cystic carcinoma are both considered to be salivary gland-type neoplasms. MECs are comparatively rare with an incidence of all lung cancers. We recently encountered a case of this type of lung cancer. A 60-year-old man was found to have an abnormal shadow in the left lower lung field on a regular check-up for lung cancer at his company. Chest radiography and CT ...

  17. Collision tumor of the frontal sinus: evidence of prior intrasinus instillation of thorotrast

    International Nuclear Information System (INIS)

    Carcinoma of the frontal sinus is relatively rare. We describe a case of two independent carcinomas, squamous cell and adenoid cystic, in the right frontal sinus region of a patient who received sinus irrigation with an unidentified, substance 30 years previously. Radioautography performed on sections of the tumor tissue revealed linear tracks of the type produced by thorium decay, strongly suggesting that the substance was thorotrast. In addition to being the first description of a ''collision tumor'' of the frontal sinus, the case would represent the first reported instance of frontal sinus carcinoma following intrasinus instillation of thorotrast

  18. Histopathological Assessment and Immunohistochemical Study of Nasopharyngeal Low Grade MALT Lymphoma

    International Nuclear Information System (INIS)

    Introduction: MALT lymphoma arises in a variety of body tissues, but most often in the stomach. Though relatively rare, these MALT lymphomas may arise within several sites in the head and neck, and often present diagnostic and therapeutic challenges. Immunohistochemical analysis are helpful in confirming the diagnosis between the MALT-lymphoma and the reactive lymphoid hyperplasia. MALT-type lymphoma demonstrated characteristic negative staining for CD3, CD5 and CD43, positive staining for CD20, and monotypic staining for either kappa or lambda light chain immunoglobulin markers, whereas reactive lymphoid hyperplasia all expressed Band T cell markers. Material and Methods: 41 cases of nasopharyngeal masses were obtained from the files at pathology department, Mansoura Faculty of Medicine through the period from 2002 till 2006. 31 cases were corresponded histomorphologically to low-grade B-cell lymphoma of mucosa associated lymphoid tissue (MALT) type and 10 patients with reactive lymphoid hyperplasia of the adenoid. Hematoxylin-eosin-stained slides were reviewed to confirm the diagnosis. Immunohistochemical studies were performed on formalin-fixed, paraffin-embedded sections using the labeled streptavidin-biotin-peroxidase complex method with DAB as chromogen. The following antibodies were evaluated CD20, CD3, Kappa, lambda and cytokeratin antibodies. Results: All cases of low grade MALT lymphoma show Iymphoepitheliallesion and proliferation of centrocyte like cells. d proliferation of centrocyte like cells. 14 cases (45.1 %) show subepithelial plasma cells. Dutcher bodies were demonstrated in 10 cases (32.2%). Monocytoid B-cells were seen in 12 cases (38.7%). Six (60%) out of the ten cases of adenoids show transmigrating lymphocyte without formation of lymphoepithelial lesion. All cases with MALT-type lymphoma expressed CD20 and not CD3 whereas 10 cases of adenoid, all expressed Band T cell markers. Immunohistochemical staining showed that 31 cases of low grade MALT lymphoma were positive for immunoglobin light chain (kappa or lambda) while 10 cases of adenoid were positive for both kappa and lambda light chain. Conclusion: Immunohistochemical analysis are helpful in confirming the diagnosis between the MALT lymphoma and the reactive lymphoid hyperplasia of the nasopharynx

  19. The "crossbow" incision and nasal flap--its blood supply and clinical application.

    Science.gov (United States)

    Hassard, A D; Holness, R O

    1984-12-01

    An anatomical study of the blood supply of the nose and upper lip was done on 10 specimens. This demonstrated the blood supply of an inferiorly based nasal flap, which was successfully used to gain access for an en bloc resection of adenoid cystic carcinoma of the ethmoid sinuses, frontal sinuses, and nose. The "crossbow" incision and inferiorly based nasal flap facilitate the tridimensional excision of lesions in the anterior base of the skull, the midline portion of middle base of the skull, and the paranasal sinuses. PMID:6096311

  20. The roles of dentisty in obstructive sleep apnea syndrome

    International Nuclear Information System (INIS)

    The roles of dentistry in obstructive sleep apnea syndrome (OSAS) are mainly: Craniofacial skeletal diagnosis, Treatment by oral appliance, Prevention of craniofacial skeletal problem. We use cephalometrics, CT and MRI to diagnose craniofacial skeleton of the patients and treat the OSAS patient by the oral appliance. We could make the airway of the OSAS patients bigger by the orthodontic treatment and ENT doctor could make the airway of the patient's patency by removing tonsils and adenoids. If the patient has the airway patency, the mandible of the patient could grow naturally in advanced position and have the airway bigger, consequently the patient could avoid OSAS in his future. (author)

  1. Prevalence of Otitis Media with Effusion Among Primary School Age-Children and Etiopathogenic Examination

    OpenAIRE

    Sanli, Arif; Tasdemir, Omer; Eken, Mehmet; Celebi, Ozlem; Yilmaz, Suleyman Hilmi

    2011-01-01

    A prevalence study was carried out in order to look into the etiopathogenic relation of otitis media with effusion (OME) in primary school-age children. The study included ENT examination and a questionnaire that was carried out in 4 randomly selected schools on 1,165 children. 143 of the cases (12.2%) had OME. A significant relation between OME and adenoid vegetation was found (P0.05). As a result, OME is a common disease that can lead to other hard-to-cure health problems and be costly if e...

  2. [Stress ulcer after tonsillectomy and adenoidectomy: one case report].

    Science.gov (United States)

    Zhang, Xiangjun; Xiao, Yang; Wang, Zhiqin

    2014-08-01

    A 11-year-old child diagnosed as chronic tonsillitis and adenoid hypertrophy underwent adeno-tonsillectomy under general anesthesia. After surgery, patient complained with abdominal discomfort, paleness and vomiting, which presented as the old black contents. Complete blood count showed: 45.2 g/L, hemoglobin of red blood cells 2.57 x 10(12)/L, An emergency gastroscopy confirmed gastric ulcer with hemorrage. Hemorrage was controlled and complete blood count results restored to normal after supportive therapy. Gastric ulcer completely recovered two weeks after discharge. PMID:25508210

  3. CASE REPORT Laser-Assisted Indocyanine Green Evaluation of Paramedian Forehead Flap Perfusion Prior to Pedicle Division

    OpenAIRE

    Shah, Ajul; Au, Alexander

    2013-01-01

    Objective: To present the use of indocyanine green and the LifeCell SpyElite System to confirm perfusion and viability of a forehead flap prior to division and inset, thereby eliminating the question of flap survival based on clinical judgment alone. Methods: A case report of a 67-year-old man with a forehead flap reconstruction following an acquired nasal defect due to resection of an adenoid cystic carcinoma is presented. LifeCell SpyElite System was used to confirm perfusion prior to pedic...

  4. A roentgenocephalometric study of the pharynx and craniofacial skeleton in Korean

    International Nuclear Information System (INIS)

    The aim of this study was to investigate the variation in shape, size and area of the pharynx and adenoids, and to analyze the relationship between pharyngeal cavity and upper facial cranium which effected on morphology of those parts in Korean. Age changes and sex differences in those areas were comprised in this study. Materials included 272 lateral cephalograms, which were divided into 4 groups by age; (1) 7-year-old group consisted of 29 males and 30 females,(2) 12-year-old group consisted of 30 males and 30 females, (3) 17-year-old group consisted of 30 males and 40 females, (4) 20-year-old group consisted of 37 males and 46 females, In subjects each variable was measured and evaluated statistically introducing 17 reference points and 17 reference lines respectively. Conclusions from this study were as follows. 1. Linear measurements of the bony nasopharynx revealed that the depth and height were larger in male than those in female in 17 and 20-year-old groups. 2. Linear measurements of the upper facial cranium were larger in male than those in female in all age groups. 3. Angular measurements of the bony nasopharynx and upper facial cranium did not show, on an average, sex differences in each age group. 4. As regards area of the bony nasopharynx, it increased gradually with age in both sexes. And the area was greater in male than that in female in 17 and 20-year-old groups. 5. There were sex differences in area of the adenoids of which the area was larger in malenoids of which the area was larger in male than that in female in 17 and 20-year-old groups. And the area reached a peak at 17-year-old group in male and at 12-year-old group in female. 6. Area of the pharyngeal cavity increased gradually with age in both sexes, but no sex differences were noted in each age group. 7. Rate of area of the adenoids to that of the pharyngeal cavity decreased continually with age, and no sex differences were noted in all age groups. 8. In amounts and its differences of the growth, there were sex differences in the posterior upper facial height, and were not in area of the bony nasopharynx, pharyngeal cavity and adenoids in each age group.

  5. Genetic and functional evidence for a role for SLC11A1 in susceptibility to otitis media in early childhood in a Western Australian population.

    Science.gov (United States)

    Rye, Marie S; Wiertsema, Selma P; Scaman, Elizabeth S H; Thornton, Ruth; Francis, Richard W; Vijayasekaran, Shyan; Coates, Harvey L; Jamieson, Sarra E; Blackwell, Jenefer M

    2013-06-01

    Otitis media (OM) is a common disease in early childhood characterised by inflammation of the middle ear. Susceptibility to recurrent acute OM (rAOM; ?3 episodes AOM in 6 months) and chronic OM with effusion (COME; middle ear effusion ?3 months) is 40-70% heritable. Three bacterial pathogens commonly associated with OM, Streptococcus pneumoniae (Sp), non-typeable Haemophilus influenzae (NTHi) and Moraxella catarrhalis (Mc), have been observed within adenoids and as facultative intracellular pathogens that invade and survive in mononuclear cells. Case/pseudo-control conditional logistic regression analysis of variants in the SLC11A1 gene, initially identified for its role in resistance to intra-macrophage pathogens in mice, revealed association with OM at four polymorphisms (Pbest=0.025) in 531 families (660 affected children) from the Western Australian Family Study of Otitis Media. This included association at the functional promoter GTn polymorphism (rs34448891) with alleles that regulate high (allele 3; odds ratio=1.2, 95% CI 1.00-1.44, P=0.04) versus low (allele 2; odds ratio=0.83, 95% CI 0.69-0.99, P=0.04) SLC11A1 expression. Haplotype and stepwise conditional logistic regression analyses support a single genetic effect in the proximal region of SLC11A1, with the haplotype 3_C_C_G across rs34448891_rs2276631_rs3731865_rs2695343 significantly (P=0.008) over-transmitted to affected offspring. Stratified analysis showed no association with OM in children who had undergone adenoidectomy (296 children), whereas children with adenoids intact (364 children) showed improved significance at the GTn polymorphism (allele 3: odds ratio=1.38, 95% CI=1.10-1.75, P=0.006). Quantitative RT/PCR demonstrated high expression of SLC11A1 in mononuclear cells isolated from adenoid tissue, with a trend for decreased expression with increasing copies of GTn allele 2. Expression of SLC11A1 was enhanced at 12 (P=1.2×10(-3)) and 24h (Pidentifies SLC11A1 as a novel candidate for OM susceptibility, particularly in children with adenoids intact. Further analysis in other cohorts is required to validate these observations. PMID:23538334

  6. Submaxilectomía: causas y complicaciones. Revisión de 160 casos / Submandibular gland excisions: causes and complications. A review of 160 cases

    Scientific Electronic Library Online (English)

    Daniel, García Molina; Rocío, Sánchez Burgos; José Luis del, Castillo Pardo de Vera; María José, Morán Soto; Natàlia, Gisbert Alemany; Miguel, Burgueño García.

    2014-06-01

    Full Text Available Objetivo: Presentamos una revisión de 160 submaxilectomías realizadas en el Hospital La Paz de Madrid durante 10 años. Material y métodos: Se revisan retrospectivamente todas las historias clínicas de los pacientes intervenidos de submaxilectomía desde enero de 2001 hasta julio de 2011. En los datos [...] se incluyen sexo, edad, anatomía patológica, pruebas diagnósticas, procedimientos quirúrgicos y seguimiento. Comparamos nuestro estudio con otros similares publicados en otros países. Resultados: En nuestra serie la sialoadenitis crónica y la sialolitiasis de la glándula submaxilar representan 114 casos (71,25%). Hay 36 casos de neoplasias (78,88% benignas y 22,22% malignas). El tumor benigno más frecuente es el adenoma pleomorfo (26 casos) y el tumor maligno más frecuente es el carcinoma adenoide quístico (7 casos). Conclusiones: En nuestro centro la causa más frecuente de submaxilectomía la constituyen la sialoadenitis crónica y la sialolitiasis. Las neoplasias más frecuentes son el adenoma pleomorfo y el carcinoma adenoide quístico, en consonancia con diferentes estudios de otros países. Los tumores benignos son más frecuentes, en contraste con otros estudios previos. Abstract in english Objective: A review is presented of 160 sub-mandibular gland excisions performed at third level hospital over a ten year period. Patients and methods: The medical records and case notes of all patients with submandibular gland excision were reviewed retrospectively from January 2001 to July 2011. Th [...] is data included gender, age, histopathology of the submandibular gland, diagnostic procedures, surgical reports, and follow-up. This study was also compared with similar studies published in other countries. Results: Chronic sialadenitis and sialolithiasis of the submandibular gland was found in 114 cases (71.25%) of the series. Thirty-six neoplasms (78.88% benign and 22.22% malignant) were found. The most frequent benign and malignant neoplasms found were pleomorphic adenoma (26 cases) and adenoid cystic carcinoma (7 cases), respectively. Conclusions: The present study showed that the main cause of sub-mandibular gland excision in our reference population was sialadenitis and sialolithiasis. The most frequent neoplasms were pleomorphic adenoma and adenoid cystic carcinoma, similar to other published reports. In this study, there was a higher incidence of benign neoplasms than in previous reports. The most common complication was facial nerve neuropraxia.

  7. Use of in vitro assays to assess the potential antiproliferative and cytotoxic effects of saffron (Crocus sativus L. in human lung cancer cell line

    Directory of Open Access Journals (Sweden)

    Samarghandian Saeed

    2010-01-01

    Full Text Available Background: Saffron is harvested from the dried, dark red stigmas of Crocus sativus flowers. It is used as a spice for flavoring and coloring food as a perfume. It is often used for treating several diseases. We investigated the potential of the ethanolic extract of saffron to induce antiproliferative and cytotoxic effects in cultured carcinomic human alveolar basal epithelial cells in comparison with non-malignant (L929 cells. Materials and Methods: Both cells were cultured in Dulbecco?s modified Eagle?s medium and treated with the ethanolic extract of saffron at various concentrations for two consecutive days. Our study resulted in sequences of events marked by apoptosis, such as loss of cell viability, morphology changes that were evaluated by MTT assay and invert-microscope, respectively. Results: The results showed that the ethanolic extract of saffron decreased cell viability in malignant cells as a concentration and time-dependent manner. The IC 50 values against the lung cancer cell line were determined as 1500 and 565 ?g/ml after 24 and 48 h, respectively. However, the extract at different concentrations could not significantly decrease the cell viability in L929 cells. Morphology of MCF7 cells treated with the ethanolic extract confirmed the MTT results. Conclusion: We also showed that even higher concentrations of saffron is safe for L929, but the extract exerts pro-apoptotic effects in a lung cancer-derived cell line and could be considered as a potential chemotherapeutic agent in lung cancer.

  8. Palliative radiotherapy for symptomatic osseous metastases

    International Nuclear Information System (INIS)

    Bone matastases are one of the most common and serious conditions requiring radiotherapy, but there is still a considerable lack of agreement on optimal radiation schedule. We analyzed patients with symptomatic osseous matastases from lung (72 patients) and breast (63 patients) carcinoma treated by palliative radiotherapy between 1983 and 1992. In this series, the incidences of symptomatic bone metastases appearing within 2 years after the first diagnosis of the primary lesion were 96% and 36% for lung and breast carcinomas, respectively. Thirty percent of bone metastases from breast carcinoma were diagnosed more than 5 years after the first diagnosis. Thus careful follow-up must be carried out for a prolonged period. Pain relief was achieved at almost the same rate for bone metastases from lung and breast carcinomas (81% and 85%, respectively), an the rapid onset of pain relief (15 Gy or less) was obtained in about half the patients for both diseases. The rapid onset of pain relief and the lack of association between the onset of pain relief and primary tumor argued against the conventional theory that tumor shrinkage is a component of the initial response. In contrast to the fact that almost all lung carcinoma patients had very poor prognoses, one third of the breast carcinoma patients were alive more than 2 years after palliative radiotherapy. Thust, the late effects of radiation, such as radiation myelopathy, must be always considered especially in breast carcinoms considered especially in breast carcinoma patients even when it is 'just' palliative radiotherapy for bone metastases. (author)

  9. Charges in haemostasis during radiotherapy of uterine carcinoma

    International Nuclear Information System (INIS)

    Clinical chemical parameters for coagulation and fibrinolysis were determined in 20 patients suffering from uterine cancer both during radium implantation with low dose anticoagulation and during the time period of percutaneous post-irradiation. In spite of strong immobilization the partial anticoagulation stabilised haemostasis. A large increase in fibrinogen concentration within the normal range of values, caused by increased production and release from the outer areas of the tumour, cannot be prevented. In addition, in the majority of cases there is a drop in AT III concentration in the pathological range. Percutaneous post-irradiation treatment for further tumour regression leads to a stabilization of the overall tests for clotting. The activated fibrinolysis and elevated levels of fibrin clearage products noted at commencement of the tests showed a normalizing tendency with progressing tumour regression and this was accompanied by a decrease in fibrinogen concentration. A low-dose anticoagulation with 3 x 5000 USP E. Heparin subcutaneous can be recommended as clinical consequences for treating frequently adipose carcinomal patients. Optimal commencement of anticoagulation is 3 hr. pre-operative. (orig./MG)

  10. Epithéliomas basocellulaires de la face: prise en charge chirurgicale, à propos de 45 cas et revue de la literature

    Science.gov (United States)

    Ennouhi, Mohamed Amine; Moussaoui, Abdenacer

    2014-01-01

    L’épithélioma basocellulaire est de loin la tumeur épithéliale maligne la plus répandue. L'atteinte faciale représente plus de 65% des cas et constitue un facteur de risque de récidive. L'objectif de notre travail est de rappeler les principes et modalités du traitement chirurgical. Sur une période de douze mois, nous avons pris en charge quarante-cinq patients atteints de carcinomes basocellulaires de la face. Le traitement chirurgical comprend deux volets: -carcinologique: emportant la tumeur et une marge de tissu sain; -et une chirurgie réparatrice faisant appel à la suture cutanée directe; greffes ou lambeaux loco -régionaux. L'examen histologique systématique des pièces opératoires permet la confirmation du diagnostic, le typage histologique et l'appréciation de la qualité de l'exérèse chirurgicale. Les résultats esthétiques sont jugés satisfaisants. Quant aux résultats carcinologiques, nous déplorons quatre récidives. Le traitement chirurgical des épithéliomas basocellulaires est le seul garant de la guérison. Au niveau de la face, il faut trouver le meilleur compromis entre impératifs carcinologiques et esthétiques. L'amélioration des résultats passe par: la prévention, le dépistage précoce des lésions, la collaboration étroite des anatomo-pathologistes et la création de comités de concertation pluri -disciplinaire pour la prise en charge des cas difficiles. PMID:25709738

  11. Radiation doses and neutron irridation effects on human cells based on calculations

    Science.gov (United States)

    Radojevic, B. B.; Cukavac, M.; Jovanovic, D.

    In general, main aim of our paper is to follow influence of neutron's radiation on materials, but one of possible applications of fast neutrons in therapeutical reasons i.e. their influence on carcinom cells of difficuilt geometries in human bodies too. Interactions between neutrons and human cells of tissue are analysed here. We know that the light nuclei of hydrogen, nitrogen, carbon, and oxygen are main constituents of human cells, and that different nuclear models are usually used to present interactions of nuclear particles with mentioned elements. Some of most widely used pre-equilibrium nuclear models are: intranuclear cascade model (ICN), Harp-Miller-Berne (HMB), geometry-dependent hybrid (GDH) and exciton models (EM). In this paper is studied and calculated the primary energetic spectra of the secundary particles (neutrons, protons, and gamas) emitted from this interactions, and followed by corresponding integral cross sections, based on exciton model (EM). The total emission cross-section is the sum of emissions in all stages of energies. Obtained spectra for interactions type of (n, n'), (n, p), and (n, ?), for various incident neutron energies in the interval from 3 MeV up to 30 MeV are analysed too. Some results of calculations are presented here.

  12. Etude histopathologique des adénopathies cervicales à Yaoundé, Cameroun

    Science.gov (United States)

    Sando, Zacharie; Fouelifack, Florent Ymele; Fouogue, Jovanny Tsuala; Fouedjio, Jeanne Hortence; Ndeby, Yvette Sandrine Ngo; Djomou, Francois; Fewou, Amadou; Oyono, Jean-Louis Essame

    2014-01-01

    Introduction Les adénopathies cervicales ont été très peu étudiées au Cameroun. Méthodes Pour améliorer leur connaissance nous avons mené une étude rétrospective et descriptive dans les cinq principaux laboratoires de la capitale du pays en vue d'en déterminer les aspects histopathologiques. Résultats Nous avons colligé 292 cas. L’âge moyen était de 30,95 ±4,11ans et le ratio homme / femme était de 0,96/1. Les principaux diagnostics histologiques étaient les suivants: tuberculose ganglionnaire (39,38%), les lymphadénites (18,49%), les lymphomes malins non hodgkiniens (12,33%), la maladie de Kaposi ganglionnaire (5,82%), les métastases de carcinome (5,82%) et la maladie de Hodgkin (5,14%). Dans 95,65% des cas le diagnostic était posé au-delà du deuxième mois d’évolution des symptômes. Conclusion Nos résultats, quoique préliminaires, sont une contribution à l'amélioration de la stratégie diagnostique et thérapeutique dans nos hôpitaux aux ressources limitées.

  13. Visualization of Abdominal Organs by Intra-Arterial Injection of 131I-Labelled Albumin Macroaggregates

    International Nuclear Information System (INIS)

    Perfusion scintigrams of the abdominal organs were made after intra-arterial injection of 131I-MAA through the lying catheter immediately after angiographic examination of the coeliac and superior mesenteric artery vascular system. The anatomical architecture of the coeliac artery makes it impossible to visualize a single organ by scanning with this technique because several organs get their blood supply from the branches of this artery. Interpretation of a perfusion scintigram alone is therefore impossible. For better interpretation some simple methods have been developed: (1) Selective or even superselective,catheterization techniques; (2) Supplementation of the perfusion scintigram by a subsequent scintigram which delineates a single organ, like-liver, by means of colloidal radiogold; and (3) Photographic superposition of one scintigram over another to give a clear identification of the individual organs, especially the pancreatic head, by subtraction of the optic density. Mostly patients suspected of pancreatic carcinome were studied. The results correlated well with those of other methods, especially coeliac arteriography, and have been-partly confirmed by surgical intervention. Thus, perfusion scintigraphy of the abdominal organs seems to be a useful complement to coeliac arteriography in diagnosing pancreatic diseases. (author)

  14. Percutaneous laser ablation of hepatocellular carcinoma in patients with liver cirrhosis awaiting liver transplantation

    International Nuclear Information System (INIS)

    Objective: The aim of this study was to determine the effectiveness and safety of percutaneous laser ablation for the treatment of cirrhotic patients with hepatocellular carcinoma awaiting liver transplantation. Materials and methods: The data of 9 male cirrhotic patients (mean age 50 years, range 45-60 years) with 12 biopsy proven nodules of hepatocellular carcinoma (mean diameter 2.0 cm, range 1.0-3.0 cm) treated by laser ablation before liver transplantation between June 2000 and January 2006 were retrospectively reviewed. Laser ablation was carried out by inserting 300 nm optical fibers through 21-Gauge needles (from two to four) positioned under ultrasound guidance into the target lesions. A continuous wave Neodymium:Yttrium Aluminium Garnet laser was used. Transarterial chemoembolization prior to liver transplantation was performed in two incompletely ablated tumors. Results: No procedure-related major complications were recorded. During the waiting time to liver transplantation local tumor progression after ablation occurred in 3 nodules (25%). At histological examination of the explanted livers complete necrosis was found in 8 nodules (66.7%, all treated exclusively with laser ablation), partial necrosis >50% in 3 nodules (25%), and partial necrosis <50% in 1 nodule. Conclusion: In patients with cirrhotic livers awaiting liver transplantation, percutaneous laser ablation is safe and effective for the management of small hepatocellular carcinoma.l hepatocellular carcinoma.

  15. Primary tumors of the trachea. Results of radiation therapy

    International Nuclear Information System (INIS)

    From 1959 to 1986, 24 patients with primary malignant tumors of the trachea received radiotherapy as all or part of treatment. Common presentations included respiratory symptoms in 20 patients and hemoptysis in 15. Thirteen patients had squamous carcinomas with undifferentiated and adenoid cystic cancers in five and four patients, respectively. Overall actuarial survival was 45% at 1 year, 25% at 5 years, and 13% at 10 years. Survival was significantly correlated to histologic type (adenoid cystic versus squamous, P less than 0.03), but not to tumor extent or to patient age or sex. Local control was attained in 10 of 24 patients overall and was more frequent for patients with tumors localized to the trachea and for patients who were treated with combined surgery and radiotherapy. For the 18 patients treated with radiotherapy alone, complete response (CR) was seen to be significantly (P less than 0.001) related to dose: six of seven (86%) patients receiving greater than or equal to 6000 cGy attained CR versus one of 11 (9%) receiving less than 6000 cGy. Three patients developed complications related to radiotherapy. Radiotherapy can provide durable local control of localized tracheal tumors and should be considered for medically inoperable patients with localized tumors and for patients with high risk of recurrence after resection

  16. Radiotherapy for primary carcinoma of the trachea

    International Nuclear Information System (INIS)

    Between 1940 and 1985, 24 cases of primary carcinoma of the trachea were registered at the London Regional Cancer Centre. The most common presenting symptoms were hoarseness, haemoptysis and cough. Twenty patients had epidermoid carcinoma and four had adenoid cystic carcinoma. Because of different clinical behaviours, the two histologies were separately analyzed. Of the 20 patients with epidermoid carcinoma, 19 received radiotherapy as primary treatment and one patient did not receive radiotherapy because of advanced disease. Radiation doses ranged from 4000 to 600 cGy and most patients had megavoltage irradiation. Treatment result was disappointing. Only one patient remained disease-free at 15-month follow-up and all other patients had persistent or recurrent tracheal tumour. Medain survival for all 20 patients was 5 months (range 1 to 19 monthes). Of the four patients with adenoid cystic carcinoma, two had primary surgery and postoperative radiotherapy and two had primary radiotherapy. Two patients died of disease, at 5 months and 8 years from diagnosis. Two surviving patients had 15 months follow-up: one had persistent disease and the other was free from recurrence. In this study, radiotherapy within the range of doses given was found to be an ineffective primary treatment for tracheal carcinoma. (author). 15 refs.; 3 tabs

  17. Computed tomography of lacrimal fossa tumors

    International Nuclear Information System (INIS)

    The lacrimal fossa can be involved by a wide spectrum of orbital pathology. The correct diagnosis is important to avoid unnecessary procedure and to do appropriate management. 14 patients with mass lesions in the lacrimal fossa were evaluated with computed tomography (CT) and clinical findings. The results were as follows: 1. Final diagnosis of 14 cases with lacrimal fossa tumors was pleomorphic adenoma in 3 cases, adenoid cystic carcinoma in 1 case, pseudotumor in 5 cases, lymphoma in 2 cases, neurofibroma in 1 case, chloroma in 1 case and metastatic adenocarcinoma in 1 case. 2. The duration of symptoms of pleomorphic adenoma was more than 1 year and characteristic CT findings were globular masses with pressure erosion of the adjacent bone. Patient with adenoid cystic carcinoma had a short history of symptoms. CT showed a fusiform mass but intracranial extension with frank destruction of sphenoid bone. 3. Patients with pseudotumor and lymphoma had symptoms for less than 1 year. The CT findings were ill-defined infiltrative patterns with scleral thickening and the differential diagnosis of them was difficult. 4. The margins of neurofibroma and chloroma were well defined while that of the metastic adenocarcinoma was ill-defined. 5. The degree and the extent of the contrast enhancement gave no benefit in the differential diagnosis of each disease entities and even of the benign and malignant lesions

  18. Computed tomography of lacrimal fossa tumors

    Energy Technology Data Exchange (ETDEWEB)

    Park, Chan Sup; Kim, Young Goo; Chang, Kee Hyun [Seoul National University College of Medicine, Seoul (Korea, Republic of)

    1985-12-15

    The lacrimal fossa can be involved by a wide spectrum of orbital pathology. The correct diagnosis is important to avoid unnecessary procedure and to do appropriate management. 14 patients with mass lesions in the lacrimal fossa were evaluated with computed tomography (CT) and clinical findings. The results were as follows: 1. Final diagnosis of 14 cases with lacrimal fossa tumors was pleomorphic adenoma in 3 cases, adenoid cystic carcinoma in 1 case, pseudotumor in 5 cases, lymphoma in 2 cases, neurofibroma in 1 case, chloroma in 1 case and metastatic adenocarcinoma in 1 case. 2. The duration of symptoms of pleomorphic adenoma was more than 1 year and characteristic CT findings were globular masses with pressure erosion of the adjacent bone. Patient with adenoid cystic carcinoma had a short history of symptoms. CT showed a fusiform mass but intracranial extension with frank destruction of sphenoid bone. 3. Patients with pseudotumor and lymphoma had symptoms for less than 1 year. The CT findings were ill-defined infiltrative patterns with scleral thickening and the differential diagnosis of them was difficult. 4. The margins of neurofibroma and chloroma were well defined while that of the metastic adenocarcinoma was ill-defined. 5. The degree and the extent of the contrast enhancement gave no benefit in the differential diagnosis of each disease entities and even of the benign and malignant lesions.

  19. Salivary gland carcinoma in Denmark 1990-2005: a national study of incidence, site and histology. Results of the Danish Head and Neck Cancer Group (DAHANCA)

    DEFF Research Database (Denmark)

    BjØrndal, Kristine; Krogdahl, Annelise

    2011-01-01

    To describe the incidence, site and histology (WHO 2005) of salivary gland carcinomas in Denmark. Nine hundred and eighty-three patients diagnosed from 1990 to 2005 were identified from three nation-wide registries. The associated clinical data were retrospectively retrieved from patient medical records. Histological revision was performed in 886 cases (90%). Based on histological revision, 31 patients (3%) were excluded from the study leaving 952 for epidemiological analysis. The mean crude incidence in Denmark was 1.1/100,000/year. The male vs. female ratio was 0.97 and the median age was 62 years. The parotid gland was the most common site (52.5%) followed by the minor salivary glands of the oral cavity (26.3%). The most frequent histological subtypes were adenoid cystic carcinoma (25.2%), mucoepidermoid carcinoma (16.9%), adenocarcinoma NOS (12.2%) and acinic cell carcinoma (10.2%). The revision process changed the histological diagnosis in 121 out of 886 cases (14%). The incidence of salivary gland carcinoma in Denmark is higher than previously reported. More than half of salivary gland carcinomas are located in the parotid gland with adenoid cystic carcinoma being the most frequent subtype. Histological classification of salivary gland carcinomas is difficult and evaluation by dedicated pathology specialists might be essential for optimal diagnosis and treatment.

  20. Clinical investigation of malignant parotid tumors

    International Nuclear Information System (INIS)

    We reviewed 55 cases of previously untreated malignant tumors arising in the parotid gland treated between Jan 1989 and May 2008. Histopathologically, we observed 13 tumor types, the most frequent histological type being mucoepidermoid carcinoma (12), followed by adenoid cystic carcinoma (11). According to clinical stage, 5 subjects were classified as T1, 18 as T2, 10 as T3, and 22 as T4. N+ cases numbered 7, and were staged as N2. Six had distant metastasis (5 lung and 1 axillary). Nineteen exhibited facial nerve palsy before treatment. Among major therapies, surgery was conducted in 50 subjects, radiation therapy in 3, and chemotherapy, and percutaneous ethanol injection therapy in each. Overall five-year survival determined using the Kaplan-Meier method was 73%. Among major histopathological types, five-year survival was 33% for undifferentiated carcinoma, 40% for adenocarcinoma, 62% for mucoepidermoid carcinoma, 67% for carcinoma in pleomorphic adenoma, and 100% for adenoid cystic carcinoma and acinic cell carcinoma. By T classification, five-year survival was 100% for T1, 88% for T2, 90% for T3, and 44% for T4. Five-year survival was 36% for those exhibiting facial nerve palsy and 94% for non palsy. Factors influencing poor outcome were T4 (p=0.001) and facial nerve palsy (p=0.001). (author)

  1. Structural and immunological characteristics of chronically inflamed adenotonsillar tissue in childhood.

    Science.gov (United States)

    Passàli, Desiderio; Damiani, Valerio; Passàli, Giulio Cesare; Passàli, Francesco Maria; Boccazzi, Antonio; Bellussi, Luisa

    2004-11-01

    Recurrent or chronic adenotonsillar infections mainly affect children and frequently involve otherwise healthy subjects. Therefore, having excluded systemic immunological deficiencies, this disease may be due to a local dysfunction of the epithelial structures at either the rhino or oropharyngeal level. The aim of the present investigation was to analyze structural and immunological aspects of tonsils and adenoids in subjects who underwent adenotonsillectomy because of recurrent inflammatory episodes with fever. Histological studies and analyses of the cytokine patterns were carried out in palatine tonsils and adenoid samples from 105 patients who underwent adenoidectomy and bilateral extracapsular tonsillectomy for chronic inflammatory hypertrophy of these organs; 46 of the 105 cases examined presented hyperkeratosis of the crypt epithelium; in the remaining 59, the epithelium was hyperplastic with no signs of keratosis. Scanning electron microscopy revealed a continuous epithelial surface of polygon-shaped flattened cells with fissures towards the cryptic depressions. Titration of interleukin-1beta and tumor necrosis factor alpha in serum and tissues demonstrated higher concentrations in the adenotonsillar specimens, whereas the rise in interleukin-6 was more modest. PMID:15539521

  2. Histopatología de cirrosis y hepatocarcinoma por Virus B / Cirrhosis and hepatocarcinoma in HBV

    Scientific Electronic Library Online (English)

    José A., Ramírez-Corrales.

    2008-11-01

    Full Text Available SciELO Costa Rica | Language: Spanish Abstract in spanish Cirrosis por virus B: Se puede detectar en biopsia el antígeno de superficie con tinción de orceína (hepatocitos esmerilados) y por inmunohistoquímica (antígeno de superficie y anticore). Estadios de evolución: a) temprano o incipiente: nódulos no definidos, mucha fibrosis y alteración arquitectural [...] ; b) establecido: nódulos rodeados completamente de bandas fibroticas. estadio histológico: a) activo: necrosis e inflamación importante, colestasis; b) Inactivo: poca necrosis o inflamación, hepatocarcinoma: (tipos): trabecular, células claras, adenoide, sólido, escirroso. La immunohistoquimica ayuda a definir el tipo usando los antígenos hepatocelulares, antígeno carcinoembriónico, citoqueratinas, cromogranina y sinaptofisina. Abstract in english HBV cirrosis: The surface antigen can be detected by biopsy, orcein tinctions (emery hepatocytes), and immunohistochemistry (surface antigen and anticore). Evolution Stages: a) Early or incipient (non-defined nodes, a lot of fibrosis and architectural alteration); b) established (nods completely sur [...] rounded by fibrotic bands). Histological Stages: a) active (main necrosis and inflammation; and cholestasis); b) inactive (little necrosisor inflammation). Types of Hepatocarcinomas: trabecular-clear cells- adenoid-solid-scirrhous. The immunohistochemistry helps to define the type using the hepatocellular antigens, carcinoembryonic antigen, cytokeratin, chromogranins and synapto-physins.

  3. Intravoxel incoherent motion MRI: emerging applications for nasopharyngeal carcinoma at the primary site

    International Nuclear Information System (INIS)

    We compared pure molecular diffusion (D), perfusion-related diffusion (D*), perfusion fraction (f) and apparent diffusion coefficient (ADC) based on intravoxel incoherent motion (IVIM) theory in patients with nasopharyngeal carcinoma (NPC). Sixty-five consecutive patients (48 men) with suspected NPC were examined using a 3.0-T MR system. Diffusion-weighted imaging (DWI) was performed with 13 b values (range, 0-800 s/mm2). We regarded the result of endoscopy and biopsy as the gold standard for detection. D, D* and f were compared between patients with primary NPC and enlarged adenoids. IVIM DWI was successful in 37 of 40 NPC and 23 of 25 enlarged adenoids cases. D (P = 0.001) and f (P 0.05). The area under the ROC curve (AUC) for D was 0.849 and was significantly larger than that for ADC (P < 0.05). IVIM DWI is a feasible technique for investigating primary NPC. D was significantly decreased in primary NPC, and increased D* reflected increased blood vessel generation and parenchymal perfusion in primary NPC. (orig.)

  4. Patterns of nodal relapse after surgery and postoperative radiation therapy for carcinomas of the major and minor salivary glands: What is the role of elective neck irradiation?

    International Nuclear Information System (INIS)

    Purpose: To evaluate the incidence of nodal relapses from carcinomas of the salivary glands among patients with clinically negative necks in an attempt to determine the potential utility of elective neck irradiation (ENI). Methods and Materials: Between 1960 and 2004, 251 patients with clinically N0 carcinomas of the salivary glands were treated with surgery and postoperative radiation therapy. None of the patients had undergone previous neck dissection. Histology was: adenoid cystic (84 patients), mucoepidermoid (60 patients), adenocarcinoma (58 patients), acinic cell (21 patients), undifferentiated (11 patients), carcinoma ex pleomorphic adenoma (7 patients), squamous cell (7 patients), and salivary duct carcinoma (3 patients); 131 patients (52%) had ENI. Median follow-up was 62 months (range, 3-267 months). Results: The 5- and 10-year actuarial estimates of nodal relapse were 11% and 13%, respectively. The 10-year actuarial rates of nodal failure were 7%, 5%, 12%, and 16%, for patients with T1, T2, T3, and T4 disease, respectively (p = 0.11). The use of ENI reduced the 10-year nodal failure rate from 26% to 0% (p = 0.0001). The highest crude rates of nodal relapse among those treated without ENI were found in patients with squamous cell carcinoma (67%), undifferentiated carcinoma (50%), adenocarcinoma (34%), and mucoepidermoid carcinoma (29%). There were no nodal failures observed among patients with adenoid cystic or acinic cell histology. Conclusion: ENI effectivc cell histology. Conclusion: ENI effectively prevents nodal relapses and should be used for select patients at high risk for regional failure

  5. Basal cell epithelioma with lymphogenic and hematogenic formation of metastases (a. o. into the myocardium)

    International Nuclear Information System (INIS)

    This report deals with a basal cell epithelioma, partially adenoid and partially morphea-like in structure, which despite intensive X-ray treatment relapsed constantly and which finally developed into an ulcus terebrans. Approximately 13 years after the primary tumor had developed (located on the left wing of the nose) both a lymphogenic and a hematogenic formation of metastases occurred with a subsequent exitus letalis 4 months later. Besides the metastases of the skin, there were multiple metastases in the lymph nodes, vertebral column, ribs, spleen, liver, stomach, pleura, and peritoneum as well as in the myocard of both ventricles and in the perimysium of the skeletal muscles. Their histological structure was similar to a partly adenoid, partily morphea-like basal cell epithelioma. The possible influence of X-ray treatment on the tumor tissue in way of benignity or malignancy is discussed in view of relevant literature on this topic. The alteration of basal cell epitheliomas into the socalled transitional epitheliomas is also analyzed. (orig.)

  6. Basal cell epithelioma with lymphogenic and hematogenic formation of metastases (a. o. into the myocardium)

    Energy Technology Data Exchange (ETDEWEB)

    Schuette, B.; Schirren, C.

    1981-01-01

    This report deals with a basal cell epithelioma, partially adenoid and partially morphea-like in structure, which despite intensive X-ray treatment relapsed constantly and which finally developed into an ulcus terebrans. Approximately 13 years after the primary tumor had developed (located on the left wing of the nose) both a lymphogenic and a hematogenic formation of metastases occurred with a subsequent exitus letalis 4 months later. Besides the metastases of the skin, there were multiple metastases in the lymph nodes, vertebral column, ribs, spleen, liver, stomach, pleura, and peritoneum as well as in the myocard of both ventricles and in the perimysium of the skeletal muscles. Their histological structure was similar to a partly adenoid, partily morphea-like basal cell epithelioma. The possible influence of X-ray treatment on the tumor tissue in way of benignity or malignancy is discussed in view of relevant literature on this topic. The alteration of basal cell epitheliomas into the socalled transitional epitheliomas is also analyzed.

  7. L-lysine in Treating Oral Mucositis in Patients Undergoing Radiation Therapy With or Without Chemotherapy For Head and Neck Cancer

    Science.gov (United States)

    2013-05-15

    Mucositis; Oral Complications of Chemotherapy; Oral Complications of Radiation Therapy; Recurrent Adenoid Cystic Carcinoma of the Oral Cavity; Recurrent Basal Cell Carcinoma of the Lip; Recurrent Lymphoepithelioma of the Nasopharynx; Recurrent Lymphoepithelioma of the Oropharynx; Recurrent Mucoepidermoid Carcinoma of the Oral Cavity; Recurrent Salivary Gland Cancer; Recurrent Squamous Cell Carcinoma of the Hypopharynx; Recurrent Squamous Cell Carcinoma of the Larynx; Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity; Recurrent Squamous Cell Carcinoma of the Nasopharynx; Recurrent Squamous Cell Carcinoma of the Oropharynx; Recurrent Verrucous Carcinoma of the Larynx; Recurrent Verrucous Carcinoma of the Oral Cavity; Stage I Adenoid Cystic Carcinoma of the Oral Cavity; Stage I Basal Cell Carcinoma of the Lip; Stage I Lymphoepithelioma of the Nasopharynx; Stage I Lymphoepithelioma of the Oropharynx; Stage I Mucoepidermoid Carcinoma of the Oral Cavity; Stage I Salivary Gland Cancer; Stage I Squamous Cell Carcinoma of the Hypopharynx; Stage I Squamous Cell Carcinoma of the Larynx; Stage I Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage I Squamous Cell Carcinoma of the Nasopharynx; Stage I Squamous Cell Carcinoma of the Oropharynx; Stage I Verrucous Carcinoma of the Larynx; Stage I Verrucous Carcinoma of the Oral Cavity; Stage II Adenoid Cystic Carcinoma of the Oral Cavity; Stage II Basal Cell Carcinoma of the Lip; Stage II Lymphoepithelioma of the Nasopharynx; Stage II Lymphoepithelioma of the Oropharynx; Stage II Mucoepidermoid Carcinoma of the Oral Cavity; Stage II Salivary Gland Cancer; Stage II Squamous Cell Carcinoma of the Hypopharynx; Stage II Squamous Cell Carcinoma of the Larynx; Stage II Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage II Squamous Cell Carcinoma of the Nasopharynx; Stage II Squamous Cell Carcinoma of the Oropharynx; Stage II Verrucous Carcinoma of the Larynx; Stage II Verrucous Carcinoma of the Oral Cavity; Stage III Adenoid Cystic Carcinoma of the Oral Cavity; Stage III Basal Cell Carcinoma of the Lip; Stage III Lymphoepithelioma of the Nasopharynx; Stage III Lymphoepithelioma of the Oropharynx; Stage III Mucoepidermoid Carcinoma of the Oral Cavity; Stage III Salivary Gland Cancer; Stage III Squamous Cell Carcinoma of the Hypopharynx; Stage III Squamous Cell Carcinoma of the Larynx; Stage III Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage III Squamous Cell Carcinoma of the Nasopharynx; Stage III Squamous Cell Carcinoma of the Oropharynx; Stage III Verrucous Carcinoma of the Larynx; Stage III Verrucous Carcinoma of the Oral Cavity; Stage IV Adenoid Cystic Carcinoma of the Oral Cavity; Stage IV Basal Cell Carcinoma of the Lip; Stage IV Lymphoepithelioma of the Nasopharynx; Stage IV Lymphoepithelioma of the Oropharynx; Stage IV Mucoepidermoid Carcinoma of the Oral Cavity; Stage IV Salivary Gland Cancer; Stage IV Squamous Cell Carcinoma of the Hypopharynx; Stage IV Squamous Cell Carcinoma of the Larynx; Stage IV Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage IV Squamous Cell Carcinoma of the Nasopharynx; Stage IV Squamous Cell Carcinoma of the Oropharynx; Stage IV Verrucous Carcinoma of the Larynx; Stage IV Verrucous Carcinoma of the Oral Cavity

  8. QUALITY OF LIFE IN CHILDREN WITH OBSTRUCTIVE SLEEP APNEA AFTER ADENOIDECTOMY

    Directory of Open Access Journals (Sweden)

    Fahrija Skokic

    2008-06-01

    Full Text Available Introduction: Sleep-disordered breathing is common in children.There is a large scale of symptoms, from plain harmless snoring to obstructive sleep apnea syndrome (OSAS. Obstructive sleep apnea in pediatric population is commonly caused by enlarged tonsils or adenoids and affects between 1% and 3% preschool and school aged population. The aim of this study was to examine quality of life in children before and after adenoidectomy, that did not have enlarged tonsils. Patients and Methods: Prospective study included 30 children with OSA symptoms both sexes from 3-12 years old consequtive admited to ENT Clinic Tuzla for adenoidectomy, without tonsillar hypertrophy,and it was carried out in the period from mid November 2005 to end of June 2006. Specific exclusion criteria were: no existing of OSA, neuromuscular disorders, constitutional maxillofacial anomalys, septal deviation, mental retardation, obesity (BMI>30. Hystory was taken from parents or caregiver, each child was examined from ENT specialist, paediatrician and anestesiologist. The adenoid size was estimated by palpation or/and X-ray examination of nasopharynx. By oropharyngoscopy was not found tonsillar hypertrophy. OSA -18 quality of life survey was used to estimate improvement of quality of life after adenoidectomy. The same parent completed OSA-18 servey before surgery and second OSA-18 servey 5 weeks after surgery. The children, that had asserted symptoms of OSA by OSA-18 quality life survey, were analysed by this survey 5 weeks after surgery.Results before and after surgery were compared. Adenoidectomy was done with standard operation technik at ENT departmant, witch includes complete removal of adenoids with uniform anestesiology protocol. Results: In 13 patients undergone adenoidectomy OSA had a small impact on quolity of life, at 13 patents had a moderate impact and at 4 patents had a large impact. Significant improovement of quality of life after adenoidectomy was found in all domains using QOL-OSA-18 test: sleep disturbance (P< .0001, physical suffering (P< .0001, emotional distress (P< .0001, daytime problems (P= .0055 and caregiver concerns (P< .0001. The mean OSA-18 –QOL total change score showed significant impruvment of quality of life in patients suffering from OSA who undergone adenoidectomy (P< .0001.

  9. Atopia e hipertrofia adenoamigdaliana em pacientes respiradores bucais em um centro de referencia / Atopy and adenotonsillar hypertrophy in mouth breathers from a reference center

    Scientific Electronic Library Online (English)

    Emanuel Capistrano, Costa Junior; Henrique Augusto Cantareira, Sabino; Carolina Sponchiado, Miura; Carolina Brotto de, Azevedo; Ullissis Padua de, Menezes; Fabiana Cardoso Pereira, Valera; Wilma Terezinha, Anselmo-Lima.

    2013-12-01

    Full Text Available SciELO Brazil | Languages: English, Portuguese Abstract in portuguese O respirador bucal utiliza a cavidade oral como principal via durante a respiração. Dentre as principais causas, destacam-se: as hipertrofias adenoamigdalianas e as doenças inflamatórias como a rinite alérgica. OBJETIVO: Verificar a presença de atopia, os principais alérgenos envolvidos e verifica [...] r a coexistência de atopia com o grau de hipertrofia das tonsilas faríngeas e palatinas, em pacientes respiradores bucais. MÉTODO: Estudo de coorte histórico com corte transversal com revisão de 308 prontuários de pacientes acompanhados em um centro do respirador bucal de um hospital terciário, no período de 2008 a 2010. Foram coletados dados sobre a história clínica de respirador bucal e realizados exames clínico otorrinolaringológico, nasofibroscópico e teste cutâneo de leitura imediata aos aeroalérgenos. RESULTADOS: Dos 308 pacientes, 36% apresentaram positividade no teste alérgico, sendo que dos atópicos 95% foram positivos para ácaros. Do total de pacientes, 46% apresentaram hipertrofia adenoideana. Destes, 37% são atópicos e 47% apresentaram hipertrofia amigdaliana e, destes, 33% são atópicos. CONCLUSÃO: Nenhuma correlação direta entre atopia e o grau de aumento das tonsilas palatinas e faríngeas foi observada nos pacientes respiradores bucais avaliados. Abstract in english Mouth breathers use the oral cavity as their principal breathing route. The main causes include: adenotonsillar hypertrophy and inflammatory diseases such as allergic rhinitis. OBJECTIVE: To look for atopy, the main allergens involved and to check for atopy as a comorbidity with the degree of hype [...] rtrophy of the tonsils and adenoids in mouth breathers. METHOD: A historical cohort study with cross-sectional review of 308 medical charts of patients treated at a mouth breather care center of a tertiary hospital in the period of 2008-2010. We collected data on the mouth breather's clinical history and we ran otolaryngological exams, flexible nasal endoscopy and skin prick test to aeroallergens. RESULTS: Of 308 patients, 36% were positive on allergy testing, with 95 % of atopic patients being positive for mites. Among all patients, 46% had adenoid hypertrophy; of these, 37% were atopic and 47% had tonsillar hypertrophy, and among these, 33% were atopic. CONCLUSION: We found no direct correlation between atopy and the degree of tonsils and adenoid hypertrophy observed among the mouth-breathing patients assessed. si.

  10. Alterações de mastigação e deglutição em crianças com hipertrofia de tonsilas / Mastication and deglutition changes in children with tonsillar hypertrophy

    Scientific Electronic Library Online (English)

    Jaqueline Freitas de, Souza; Tais Helena, Grechi; Wilma Terezinha, Anselmo-Lima; Luciana Vitaliano Voi, Trawitzki; Fabiana Cardoso Pereira, Valera.

    2013-08-01

    Full Text Available SciELO Brazil | Languages: English, Portuguese Abstract in portuguese As alterações de mastigação e de deglutição em crianças com hipertrofia adenoamigdaliana precisam ser melhor caracterizadas. OBJETIVO: Avaliar a frequência das alterações miofuncionais autorreportadas pelos pais, e se há diferenças entre os padrões de alterações entre crianças com hipertrofia adenoa [...] migdaliana e as com hipertrofia apenas adenoideana. MÉTODO: Aplicação de questionário e avaliação clínica fonoaudiológica em crianças com hipertrofia de tonsilas com idade entre 3 e 6 anos. Os dados reportados pelos pais foram comparados com os dados obtidos pela avaliação fonoaudiológica; além disso, os dados das crianças com hipertrofia adenoamigdaliana foram comparados com as com hipertrofia adenoideana. Desenho científico: coorte transversal. RESULTADOS: As alterações miofuncionais observadas pela fonoaudióloga foram muito mais frequentes do que as reportadas pelos pais e não houve concordância entre os dois achados. As crianças com hipertrofia adenoideana e as com hipertrofia adenoamigdaliana apresentaram o mesmo padrão de alterações miofuncionais. CONCLUSÃO: Os pais relacionam pouco a hipertrofia de tonsilas a alterações na mastigação e na deglutição. A causa da obstrução respiratória parece não interferir no padrão de alteração miofuncional. Abstract in english The changes in mastication and deglutition in children with adenotonsillar hypertrophy need to be better characterized. OBJECTIVE: To evaluate the frequency of parent-reported myofunctional changes and to determine if there are differences in the alteration patterns of children with adenotonsillar h [...] ypertrophy and subjects with adenoid hypertrophy. METHOD: Questionnaire and assessment by a speech therapist of children aged between three and six years with tonsillar hypertrophy. The data reported by the parents were compared to the data obtained from the speech therapist's evaluation; additionally, data from children with adenotonsillar hypertrophy were compared to findings from subjects with adenoid hypertrophy. Study Design: cross-sectional cohort. RESULTS: The myofunctional changes observed by the speech therapist were more frequent than the alterations reported by the parents, and there was no correlation between the two findings. The children with adenoid hypertrophy and the individuals with adenotonsillar hypertrophy had the same pattern of myofunctional alteration. CONCLUSION: Parents cannot clearly correlate tonsillar hypertrophy with changes in mastication and deglutition. The cause of the respiratory obstruction does not seem to interfere in the pattern of myofunctional change.

  11. Photodynamic Therapy Using HPPH in Treating Patients Undergoing Surgery for Primary or Recurrent Head and Neck Cancer

    Science.gov (United States)

    2015-01-20

    Recurrent Adenoid Cystic Carcinoma of the Oral Cavity; Recurrent Basal Cell Carcinoma of the Lip; Recurrent Esthesioneuroblastoma of the Paranasal Sinus and Nasal Cavity; Recurrent Inverted Papilloma of the Paranasal Sinus and Nasal Cavity; Recurrent Lymphoepithelioma of the Nasopharynx; Recurrent Lymphoepithelioma of the Oropharynx; Recurrent Metastatic Squamous Neck Cancer With Occult Primary; Recurrent Midline Lethal Granuloma of the Paranasal Sinus and Nasal Cavity; Recurrent Mucoepidermoid Carcinoma of the Oral Cavity; Recurrent Salivary Gland Cancer; Recurrent Squamous Cell Carcinoma of the Hypopharynx; Recurrent Squamous Cell Carcinoma of the Larynx; Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity; Recurrent Squamous Cell Carcinoma of the Nasopharynx; Recurrent Squamous Cell Carcinoma of the Oropharynx; Recurrent Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity; Recurrent Thyroid Cancer; Recurrent Verrucous Carcinoma of the Larynx; Recurrent Verrucous Carcinoma of the Oral Cavity; Stage I Adenoid Cystic Carcinoma of the Oral Cavity; Stage I Basal Cell Carcinoma of the Lip; Stage I Esthesioneuroblastoma of the Paranasal Sinus and Nasal Cavity; Stage I Follicular Thyroid Cancer; Stage I Inverted Papilloma of the Paranasal Sinus and Nasal Cavity; Stage I Lymphoepithelioma of the Nasopharynx; Stage I Lymphoepithelioma of the Oropharynx; Stage I Midline Lethal Granuloma of the Paranasal Sinus and Nasal Cavity; Stage I Mucoepidermoid Carcinoma of the Oral Cavity; Stage I Papillary Thyroid Cancer; Stage I Salivary Gland Cancer; Stage I Squamous Cell Carcinoma of the Hypopharynx; Stage I Squamous Cell Carcinoma of the Larynx; Stage I Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage I Squamous Cell Carcinoma of the Oropharynx; Stage I Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity; Stage I Verrucous Carcinoma of the Larynx; Stage I Verrucous Carcinoma of the Oral Cavity; Stage II Adenoid Cystic Carcinoma of the Oral Cavity; Stage II Basal Cell Carcinoma of the Lip; Stage II Esthesioneuroblastoma of the Paranasal Sinus and Nasal Cavity; Stage II Follicular Thyroid Cancer; Stage II Inverted Papilloma of the Paranasal Sinus and Nasal Cavity; Stage II Lymphoepithelioma of the Nasopharynx; Stage II Lymphoepithelioma of the Oropharynx; Stage II Midline Lethal Granuloma of the Paranasal Sinus and Nasal Cavity; Stage II Mucoepidermoid Carcinoma of the Oral Cavity; Stage II Papillary Thyroid Cancer; Stage II Salivary Gland Cancer; Stage II Squamous Cell Carcinoma of the Hypopharynx; Stage II Squamous Cell Carcinoma of the Larynx; Stage II Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage II Squamous Cell Carcinoma of the Oropharynx; Stage II Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity; Stage II Verrucous Carcinoma of the Larynx; Stage II Verrucous Carcinoma of the Oral Cavity

  12. Escolares submetidos a videonasofaringoscopia na escola: achados e aceitação / Schoolchildren submitted to nasal fiber optic examination at school: findings and tolerance

    Scientific Electronic Library Online (English)

    Rubens S., Santos; Rosana, Cipolotti; Jeferson S., D' Ávila; Ricardo Q., Gurgel.

    2005-12-01

    Full Text Available SciELO Brazil | Languages: English, Portuguese Abstract in portuguese OBJETIVO: Verificar a aceitação da videonasofaringoscopia por crianças, no ambiente escolar, para avaliação de vegetações adenoideanas e determinar a sua prevalência nessa população MÉTODO: Estudo transversal realizado em amostra proporcional (n = 368) de escolares da primeira série do ensino fundam [...] ental de Aracaju (SE), com idades entre 6 e 13 anos, submetidos a videonasofaringoscopia flexível. Todas se submeteram à mesma rotina de exame, feito na própria escola, sem a necessidade de contenção ou qualquer tipo de sedação. RESULTADOS: As crianças que foram submetidas a avaliação nasofibroscópica aceitaram bem o procedimento, permitindo a adequada avaliação das cavidades do nariz e nasofaringe. A prevalência de hipertrofia adenoideana grau I foi de 50,6%, a de grau II foi de 35,1% e a de grau III foi de 14,3%. As hipertrofias adenoideanas graus II e III apresentam maior número de sintomas obstrutivos. CONCLUSÃO: A videonasofaringoscopia flexível pode ser realizada, com excelente aceitação, fora do ambiente hospitalar ou consultório, como mostra este estudo realizado em ambiente escolar, indicando que sua utilização pode ser mais ampla, tornando-a mais acessível a um maior número de pessoas. A prevalência dos três graus de hipertrofia adenoideana encontrada em Aracaju difere de alguns estudos por ter sido realizada em crianças não triadas para sintomas respiratórios. Abstract in english OBJECTIVE: To verify children's acceptance of nasal fiber optic examination in a school setting and to evaluate hypertrophy of adenoid vegetation and to determine its prevalence in this population. METHODS: A survey was performed of a representative (n = 368) sample of school age children at element [...] ary school (aged 6 to 13 years old) who had been subjected to fiber optic examination, in Aracaju (SE), Brazil. All students were subjected to the same study protocol, carried out at school and with no need for sedation or restraint. RESULTS: All of the children tolerated the nasal fiber optic examination well, making possible a good evaluation of pharynx and nasal cavities. The prevalence of adenoid hypertrophy grade I was 50.6%, of grade II 35.1% and of grade III 14.3%. Grades II and III hypertrophy were related to an increase in obstructive symptoms. CONCLUSION: As this study performed in a school setting demonstrates, nasal fiber optic examination can be performed with excellent tolerance in settings other than hospitals and outpatient clinics, indicating that its usage could be increased and made available for an extended range of populations. The prevalence of adenoid hypertrophy in Aracaju is not comparable with prevalence rates observed in earlier studies because it this was a study of children without respiratory symptoms.

  13. Une tumeur rare et distincte du cancer du sein: le carcinosarcome, à propos de huit cas et revue de la littérature

    Science.gov (United States)

    Ghanem, Samia; Khoyaali, Siham; Naciri, Sara; Glaoui, Meriem; Mesmoudi, Mohamed; Errihani, Hassan

    2013-01-01

    Le carcinosarcome du sein souvent appelé carcinome métaplasique du sein, est une tumeur maligne rare composée de deux lignées cellulaires distinctes, il est décrit comme un cancer du sein de type canalaire avec un composant de type sarcome. Il représente 0,08-0.2% de toutes les tumeurs malignes du sein. Il s'agit d'une étude rétrospective étalée sur un an, huit cas des carcinosarcomes mammaires ont été colligés à l'Institut national d'oncologie au Maroc durant l'année 2007. La médiane d’âge était de 49,5 ans, toutes les tumeurs étaient de haut grade, cliniquement 5 cas ont été classé t2 ou t3, et 3 cas classé sein localement avancé. Le traitement envisagé était basé sur une chirurgie mammaire suivie d'une radiothérapie et d'une chimiothérapie pour les cas adjuvants, l'envahissement ganglionnaire a été noté dans un cas, les récepteurs œstrogèniques sont négatifs, alors que les récepteurs progesteroniques sont positifs dans 4 cas, l'expression d'Her2 est absente dans tous les cas, le traitement des carcinosarcomes mammaires métastatiques était basé sur une chimiothérapie palliative. A 20 mois de médiane follow-up, la survie sans progression(SSP) pour le groupe entier est de 62,5%. Dans la limite de ce suivi, une rechute locorégionale a été détectée dans un cas, les deux patientes métastatiques sont décédées. Le carcinosarcome du sein est un sous-type rare du cancer du sein qui a un profil particulier et agressif, il a souvent un caractère triple négatif. Il est nécessaire de développer d'autres voies de recherche comme cibler le Récepteur HER1/EGFR. PMID:23734272

  14. Value and indication of radiotherapy in the endometrical carcinoma

    International Nuclear Information System (INIS)

    Today the endometrial carcinoma is the most frequent malignant tumor found in female genital tract. Endometrial carcinoma ought to be operated in all cases, if possible. Traditionally some form of adjuvant radiotherapy has been given. Despite the large number of patients treated by combined therapy over the last 30 years, surprisingly there is a lack of hard data on which to establish a theory for an improved outcome. It is generally accepted that the risk of local relapses in the vagina is lowered when postoperative vaginal irradiation is applied. The question of the value of additional external irradiation in stage I endometrial cancer still is unsetteled. Only two prospective studies led to the conclusion that only patients with poorly differentiated tumors and with deep infiltration of the myometrium might benefit from additional external radiotherapy. Therefore a simple score for these risk factors is proposed enabling assignment into patient groups of similar risk on the base of a point system due to individual prognostic factors. With a score of one to two points prognosis is very good and adjuvant irradiation seems not to be necessary. With three to four points local vaginal irradiation is recommended, with five and more points additionally external beam irradiation to the pelvis should be given. This is necessary in more than the half of the operated cases of endometrial carcinoma. The indication for such a treatment has become more individual and 'high risk'has become more individual and 'high risk' cases are treated more intensively, but 'low risk' cases have to be excepted from unnecessary adjuvant therapy. In order to judge an individual case of endometrial cancer histopathologic prognosticators have to be considered. Typical adenocarcinomas have a five-year survival of more than 80%, but unfavourable subtypes (adenosquamous, clearcell, serous-papillary carcinoms) of only 40%, respectively. Tumorgrading and depth of myometrial invasion are of high importance for individual prognosis. (orig./MG)

  15. Value and indication of radiotherapy in the endometrical carcinoma. Wert und Indikation der Strahlentherapie beim Endometriumkarzinom

    Energy Technology Data Exchange (ETDEWEB)

    Kucera, H. (Vienna Univ. (Austria). Strahlenabteilung der 1. und 2. Frauenklinik)

    1991-07-01

    Today the endometrial carcinoma is the most frequent malignant tumor found in female genital tract. Endometrial carcinoma ought to be operated in all cases, if possible. Traditionally some form of adjuvant radiotherapy has been given. Despite the large number of patients treated by combined therapy over the last 30 years, surprisingly there is a lack of hard data on which to establish a theory for an improved outcome. It is generally accepted that the risk of local relapses in the vagina is lowered when postoperative vaginal irradiation is applied. The question of the value of additional external irradiation in stage I endometrial cancer still is unsetteled. Only two prospective studies led to the conclusion that only patients with poorly differentiated tumors and with deep infiltration of the myometrium might benefit from additional external radiotherapy. Therefore a simple score for these risk factors is proposed enabling assignment into patient groups of similar risk on the base of a point system due to individual prognostic factors. With a score of one to two points prognosis is very good and adjuvant irradiation seems not to be necessary. With three to four points local vaginal irradiation is recommended, with five and more points additionally external beam irradiation to the pelvis should be given. This is necessary in more than the half of the operated cases of endometrial carcinoma. The indication for such a treatment has become more individual and 'high risk' cases are treated more intensively, but 'low risk' cases have to be excepted from unnecessary adjuvant therapy. In order to judge an individual case of endometrial cancer histopathologic prognosticators have to be considered. Typical adenocarcinomas have a five-year survival of more than 80%, but unfavourable subtypes (adenosquamous, clearcell, serous-papillary carcinoms) of only 40%, respectively. Tumorgrading and depth of myometrial invasion are of high importance for individual prognosis.

  16. Effect of intratumoral heterogeneity in oxygenation status on FMISO PET, autoradiography, and electrode PO 2 measurements in murine tumors

    International Nuclear Information System (INIS)

    Purpose: To explore conflicting results obtained when tumor hypoxia is assessed with Eppendorf electrode PO 2 measurements and with positron emission tomography (PET) by use of [18F]fluoromisonidazole (FMISO). Methods and Materials: We compared the 2 methods in conjunction with 2-[18F]fluoro-2-deoxy-D-glucose (FDG) PET, dual-tracer ex vivo autoradiography (FMISO and 2-deoxy-D-[1-14C]glucose (2DG)), and histology in 2 murine tumor models, the C3H mammary carcinoma and the SCCVII squamous cell carcinoma. Results: 2-[18F]fluoro-2-deoxy-D-glucose (FDG)-PET showed tumor-to-reference tissue ratios of 3.5 in both tumor models after 2 hours. C3H mammary carcinoma reached an FMISO PET ratio of 11 after 3.5 hours. Autoradiography showed large confluent areas of FMISO and 2DG uptake. Median PO 2 was 7 mm Hg and necrotic fraction was 10% to 30%. SCCVII squamous-cell carcinoma reached an FMISO PET tumor-to-reference tissue ratio of 2 after 2.5 hours. Autoradiography showed homogeneous 2DG uptake and scattered foci of high FMISO uptake. Median PO 2 was 1 mm Hg and necrotic fraction was below 5%. Conclusions: Ex vivo dual-tracer autoradiography documented the ability of in vivo FMISO PET to distinguish between confluent areas of either viable tissue or necrosis. Electrode PO 2 measurements could not be ascribed to specific areas in the tumors. Less uptake of FMISO in SCCVII squamous-cell carcinom of FMISO in SCCVII squamous-cell carcinoma than in C3H mammary carcinoma could be caused by scattered foci versus confluent areas of viable hypoxic tissue in the 2 tumors, respectively

  17. Carcinoma não medular familiar da tiróide / Familial nommedullary thyroid cancer

    Scientific Electronic Library Online (English)

    Roberto Bernardo, Santos; Thaís Gomes de, Melo; Lígia V. Montali, Assumpção.

    2007-07-01

    Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese O carcinoma diferenciado da tiróide, papilífero ou folicular, origina-se da célula folicular tiroideana, sendo a neoplasia maligna mais freqüente desta glândula. Desde 1955 têm sido relatados casos de agrupamento familiar deste carcinoma, e atualmente estima-se que 4,2% de todos os carcinomas difere [...] nciados da tiróide tenham origem familiar. Esses casos costumam ser mais agressivos, incidem em idade mais precoce, são multifocais e apresentam maior taxa de recorrência. Parecem ser transmitidos por herança autossômica dominante com penetrância variável, mas os genes exatos responsáveis pela doença ainda não foram totalmente identificados. Os pacientes devem ser tratados com tiroidectomia total e freqüentemente também com esvaziamento linfonodal cervical, seguidos de ablação com iodo radioativo e terapia supressiva do TSH com levotiroxina. Alguns autores recomendam rastreamento de familiares de primeiro grau dos pacientes afetados através da ultrassonografia cervical, com objetivo de realizar diagnóstico precoce, possibilitando melhores resultados terapêuticos. Abstract in english Nonmedullary thyroid carcinoma, originating from thyroid epithelial cells, is the most frequent thyroid malignant neoplasia. Since 1955, there has been increasing evidence that this cancer may have a familial predisposition. It is now established that around 4.2% of all nonmedullary thyroid carcinom [...] as occurs on the background of familial predisposition. These cases are often more aggressive, due to early onset, multifocality and a higher percentual of recurrences. An autossomal dominant inheritance pattern appears likely in most families, although the exact genes responsible for this syndrome have not yet been identified. Patients affected by this cancer should be treated with total thyroidectomy routinely and, in most cases, lymph node dissection, followed by iodine ablation and TSH suppressive therapy with levothyroxine. Some authors also recommend that first-degree relatives of patients with nonmedullary thyroid cancer (especially women) should be submitted to neck ultrasound for thyroid cancer screening, aiming early diagnosis for better treatment results.

  18. Preoperative combination therapy of 5-fluorouracil suppository and radiation for carcinoma of the rectum

    International Nuclear Information System (INIS)

    The effect of adjuvant preoperative treatments with radiation and 5-fluorouracil (5-FU) on rectal carcinomas was investigated. The radiation therapy was administered in the area including the rectum and regional lymph nodes up to the level of the promontorium with 10 doses of 300 rad in three-week periods (a total dose of 3,000 rad). The suppository containing 100 mg of 5-FU was given intrarectally twice daily in the same period (a total dose of 4,000 mg of 5-FU). The surgical procedure with either abdominoperineal excision or anterior resection was performed within 14 days after the last preoperative treatment. The resected specimens were examined microscopically. The mean thickness of excised tumor-free tissue around the rectal wall having the most extended tumor growth was 6.2 mm in 16 patients receiving the treatment with radiation and 5-FU, 3.9 mm in 31 patients with 5-FU alone and 3.7 mm in 19 patients without preoperative treatments. Lymph node metastases were detected in 3 of 17 patients (19 %) with radiation and 5-FU, in 18 of 33 patients (55 %) with 5-FU alone, and in 11 of 24 patients (46 %) without preoperative treatments. The extensive degenerative pictures of cancer cells such as nuclear picnosis, and the growth of collagen fibers in carcinoma foci were observed in resected specimens with radiation and 5-FU treatments. Those findings suggest that preoperative adjuvant therapy with moderate dose of radiation and 5-FU affected significantly rectal carcinom-FU affected significantly rectal carcinomas. There were no adverse effects. It seems likely, thus, that this combined therapy could prevent postoperative local or intrapelvic recurrence, which was the most frequent form of recurrence after curative surgery in rectal cancer. (author)

  19. Les tumeurs malignes primitives de l’intestin grèle: Aspects cliniques et thérapeutiques de 27 patients

    Directory of Open Access Journals (Sweden)

    Abahssain Halima

    2011-03-01

    Full Text Available Les tumeurs malignes de l'intestin grèle (TMPIG sont des tumeurs rares. Elles représentent 1 à 5% de toutes les tumeurs du tube digestif. Elles sont caractérisées par une hétérogénéité anatomopathologique et une symptomatologie pauvre et non spécifique entrainant ainsi un retard diagnostic, des difficultés Thérapeutiques et donc un mauvais pronostic. Nous rapportant les caractéristiques épidémiologiques, diagnostiques et thérapeutiques ainsi que la survie des patients atteints des TMIG au sein de l’institut national d’oncologie de Rabat. Il s’agit d’une analyse rétrospective des dossiers cliniques des 27 patients ayant le diagnostic de tumeurs malignes de l’intestin grèle admis dans notre institut entre 1998 et 2002. L’âge médian était de 46 ans (15-70 ans. Le délai médian de diagnostic était de 6 mois (0-96 mois. La douleur abdominale était le symptôme le plus fréquent (77.8%. L’étude anatomopathologique a montré 63% de lymphome non Hodgkinie, 14.8% d’adénocarcinome, 7.4% de tumeur stromale, 7.4% de carcinome neuroendocrine et 7.4% de sarcome intestinal. Vingt patients (76. 9% ont eu une résection chirurgicale et 14 patients (53. 8% ont eu une chimiothérapie en fonction du stade de la maladie et du type histologique. Après un recul médian de 11.6 mois, la survie globale après 12 mois était de 44.4% et la médiane de survie était de 11.6 mois. Les tumeurs malignes de l’intestin grèle sont rares. Leur diagnostic est tardif limitant ainsi la prise en charge thérapeutique curative. Les cliniciens doivent ètre avertis des symptômes gastro-intestinaux non spécifiques

  20. Diagnostic evaluation of 67Ga citrate and 99mTc-MDP scintigraphy in head and neck malignant tumors

    International Nuclear Information System (INIS)

    The usefulness of 67Ga-citrate and 99mTc-MDP scintigraphy were investigated using 81 patients with head and neck malignant tumor. The detection rate for primary and metastatic lesions was defined as the true-positive rate (TPr). In salivary gland tumor, TPr of 67Ga citrate scintigraphy were higher than squamous cell carcinoma. In squamous cell carcinoma, TPr of 67Ga citrate scintigraphy correlated with the tumor size of primary lesions. In squamous cell carcinoma, TPr of the tongue and floor of the mouth were lower than any other site. In the metastatic lesions of adenoid cystic carcinoma, significant difference of TPr of 67Ga citrate scintigraphy appeared among the cases. 99mTc-MDP scintigraphy provided very useful information for evaluating the presence of tumor invasion to bone in the primary region and bone metastatic region. (author)

  1. Neutron therapy for malignant tumours of the salivary glands

    International Nuclear Information System (INIS)

    A group of 28 patients with malignant tumours of the salivary glands have been treated by d(15)+Be neutron irradiation. Nineteen patients had inoperable cancers. Three had gross recurrent cancer and three had measurable residual cancer after surgery. Three patients were treated post-operatively for microscopic residual disease. Seven different histological types of tumour were included. Six out of 8 patients with adenoid cystic carcinomas have lasting local tumour control. 54% of the gross tumours were locally controlled. All three of those classified as microscopic residual disease have no evidence of local recurrence. 11/14 cancers given 16.0 Gy or more in 20 fractions in 4 weeks were controlled compared with only 1/8 given a lower dose. 12/19 cancers less than 10.0 cm maximum diameter were controlled. The radiation-related morbidity was similar to that observed after photon therapy. (Auth.)

  2. Thyroid and associated polyglandular neoplasms in patients who received head and neck irradiation during childhood

    International Nuclear Information System (INIS)

    One hundred fifty-one patients with a history of childhood irradiation to the head, neck, and thorax had neck explorations (142 for cold thyroid nodules and 9 for hypercalcemia). Fifty-nine of the patients had thyroid carcinoma, and associated glandular tumors were found in 20 others. In addition, 6 female patients developed breast carcinoma; 4 of these women also had thyroid carcinoma. In this series, 48.6% of the patients irradiated for acne and 36.4% with tonsil and adenoid irradiation developed thyroid carcinoma, but only 10.5% with thymic irradiation did so. It is suggested that the workup on these patients include not only complete thyroid and parathyroid testing, but also a careful examination of all salivary glands, both major and minor. Women should have thorough breast examinations and should perhaps be followed as if they were in the potentially high-risk breast group. When thyroid surgery is performed, a total thyroidectomy is recommended

  3. Experience with malignant tumours of the maxillary sinus in the Department of Otolaryngology Universiti Kebangsaan Malaysia, Kuala Lumpur.

    Science.gov (United States)

    Lokman, S; Said, H; Hakim, J; Yusop, S

    1989-03-01

    Thirty one cases of malignant tumours of the maxillary sinus presenting to the Department of Otolaryngology, Universiti Kebangsaan Malaysia over a four year period from 1982 to 1986 are reviewed. 18 cases (58.1%) were squamous cell carcinoma while seven cases (22.5%) were Non-Hodgkin's lymphoma. There were four cases (12.0%) of adenoid cystic carcinoma while in two cases (6.5%) the tumours were undifferentiated. Presentation was generally late. Nasal obstruction, facial swelling and epistaxis were the main presenting symptoms. Nasal involvement was found in 61.3% of cases, while 51.6% had involvement of the palate as well. Metastasis to the cervical lymph node were uncommon (6.5%). Surgery and radiotherapy with or without chemotherapy were the main modes of treatment in the management of malignant tumours of the maxillary sinus. PMID:2626115

  4. Pseudoangiosarcomatous squamous cell carcinoma of skin arising adjacent to decubitus ulcers.

    Science.gov (United States)

    Conde-Taboada, Alberto; Flórez, Angeles; De la Torre, Carlos; Feal, Carlos; García-Doval, Ignacio; Cruces, Manuel

    2005-04-01

    Pseudoangiosarcomatous, or pseudovascular, squamous cell carcinoma of skin is an unusual form of acantholytic (adenoid, pseudoglandular) squamous cell carcinoma that mimics the histolopathologic appearance of angiosarcoma. We report a case of pseudoangiosarcomatous squamous cell carcinoma arising adjacent to decubitus ulcers. The histopathologic examination of a wedge biopsy specimen revealed infiltrative cords of neoplastic cells that formed interanastomosing channels imitating angiosarcoma. Immunohistochemical staining was negative for the endothelial markers (CD31, CD34, and factor VIII-related antigen) and positive using cytokeratin antibodies (AE1/AE3 and 34 betaE12). Because of metastatic disease, palliative measures were undertaken and the patient died four months later. To our knowledge, our patient is the first with pseudoangiosarcomatous squamous cell carcinoma of skin developing within decubitus ulcer. PMID:15798440

  5. A case of presumed radiation optic neuropathy

    Energy Technology Data Exchange (ETDEWEB)

    Atsumi, Osamu; Sakuraba, Tomoki; Kimura, Satoru; Narita, Kiyoharu; Maeda, Syuji (Hirosaki Univ., Aomori (Japan). School of Medicine)

    1991-05-01

    A case of a 37-year-old woman with radiation optic neuropathy was reported. She had undergone subtotal removal of the right orbital tumor (adenoid cystic carcinoma) by frontal craniotomy, followed by radiation therapy (64 Gy). She had been quite well until she noticed a gradual loss of vision in her right eye 18 months later. Her visual acuity was 0.2 in the right eye and 1.5 in the left eye with right relative afferent pupillary defect and dense central scotoma. Funduscopy revealed optic disc swelling with surrounding retinal edema and small hemorrhage in the right eye. Fluorescein angiography revealed a hypoperfusion area and obstruction of the small retinal vessels in the posterior pole, but this was not large enough to explain the dense central scotoma. Although prednisolone therapy gave temporary improvement, the visual function gradually deteriorated. (author).

  6. Computed tomography of the nasopharynx and related spaces. Part II: pathology

    Energy Technology Data Exchange (ETDEWEB)

    Silver, A.J.; Mawad, M.E.; Hilal, S.K.; Sane P.; Ganti, S.R.

    1983-06-01

    Malignant tumors of the nasopharynx were analyzed by region of origin and route of spread. Nasopharyngeal carcinomas produced early submucosal infiltration of the deglutitional muscle layer with enlargement of the levator palati muscle and lateral displacement of the parapharyngeal space. Serious otitis media was frequently associated, and the trigeminal nerve was occasionally involved. Intracranial extension via the foramen lacerum was frequent. Metastases to the infratemporal fossa produced early involvement of the masticatory muscle layer with medial displacement of the parapharygeal space. Adenoid cystic carcinomas showed late but disproportionate involvement of the sphenoid sinus. Chordomas extended into the retropharyngeal soft tissues via the petro-occipital fissure. Maxillary sinus carcinomas, which were very large at the time of presentation and impinged on the nasopharynx, showed extensive destruction of the pterygoid plates.

  7. Calculation of neutron kerma in tissues

    International Nuclear Information System (INIS)

    Neutron kerma of normal and tumor tissues has been calculated using the tissues elemental concentration. A program developed in Math cad contains the kerma factors of C, H, O, N, Na, Mg, P, S, Cl, K, etc. that are in normal and tumor human tissues. Having the elemental composition of any human tissue the neutron kerma can be calculated. The program was tested using the elemental composition of tumor tissues such as sarcoma, melanoma, carcinoma and adenoid cystic, also neutron kerma for adipose and muscle tissue for normal adult was calculated. The results are in agreement with those published in literature. The neutron kerma for water was also calculated because in some dosimetric calculations water is used to describe normal and tumor tissues. From this comparison was found that at larger energies kerma factors are approximately the same, but energies less than 100 eV the differences are large. (Author)

  8. Controlling distant metastasis and surgical treatment are crucial for improving clinical outcome in uncommon head and neck malignancies, such as non-squamous cell carcinoma

    Science.gov (United States)

    SHIIBA, MASASHI; UNOZAWA, MOTOHARU; HIGO, MORIHIRO; KOUZU, YUKINAO; KASAMATSU, ATSUSHI; SAKAMOTO, YOSUKE; OGAWARA, KATSUNORI; UZAWA, KATSUHIRO; TAKIGUCHI, YUICHI; TANZAWA, HIDEKI

    2014-01-01

    The objective of this study was to elucidate the clinical characteristics of uncommon head and neck malignancies, such as non-squamous cell carcinoma (SCC), in order to improve patient outcomes. A total of 463 head and neck malignancies were retrospectively analyzed, with 43 cases (9.3%) diagnosed as non-SCC. The overall survival rate of patients with adenoid cystic carcinoma was significantly worse compared to that of patients with SCC. The 5-year survival rates were <50% for patients with malignant melanoma, adenocarcinoma, small-cell carcinoma and sarcomas. Distant metastasis to the lung was frequently observed in cases with a poor outcome. Non-SCC malignancies treated without surgery were associated with a worse outcome. Some non-SCC patients had a poor prognosis and distant metastasis was associated with an unsatisfactory outcome. Timely treatment and control of distant metastasis are essential and surgical treatment should be prioritized in non-SCC cases to improve patient outcomes. PMID:24940505

  9. Clinical analysis of 47 primary parotid cancers

    Energy Technology Data Exchange (ETDEWEB)

    Kawana, Masahiro; Sato, Katsuro; Sato, Yuichiro; Hanazawa, Hideyuki; Takahashi, Sugata [Niigata Univ. (Japan). School of Medicine

    2001-03-01

    A retrospective study was performed on 47 patients with primary malignant neoplasms of the parotid gland treated in our department between 1982 and 1999. Most of the patients were male and over age 40, and 23 patients were of stage IV in clinical classification. The most frequently observed histological type was adenocarcinoma (12 patients), and the next was adenoid cystic carcinoma (11 patients). A radical parotidectomy with postoperative radiation therapy was administered in 38 patients, and palliative treatment in 9. The global survival rate was 74.1% at 5 years, and 89.4% in the patients treated with the radical procedure. Radical operative treatment and subsequent over 50-Gy of irradiation supposed to be the important factor to improve the prognosis. (author)

  10. Reticular type parotid myoepithelial carcinoma: an intriguing variant and mimicker

    International Nuclear Information System (INIS)

    Myoepithelial carcinoma, the malignant counterpart of benign myoepithelioma, is one of the rarest salivary gland neoplasms. It is composed almost exclusively of tumour cells with myoepithelial differentiation, characterized by infiltrative growth and potential for metastasis. We herein, report a case of myoepithelial carcinoma in a 50 years old male with reticular morphology. Reticular variant of myoepithelial carcinoma may be mistaken for a variety of benign and malignant epithelial and mesenchymal tumours including mixed tumour (pleomorphic adenoma), adenoid cystic carcinoma, basal cell adenoma and epithelial myoepithelial carcinoma. Complete surgical excision is the mainstay of therapy. The role of radiation therapy and chemotherapy is not yet established. Awareness of this variant is emphasized to prevent misdiagnosis. (author)

  11. Heavy ion radiotherapy for the head and neck cancer

    Energy Technology Data Exchange (ETDEWEB)

    Mizoe, Junetsu; Ohsaka, Yasuhiro; Tsujii, Hirohiko [National Inst. of Radiological Sciences, Chiba (Japan). Research Center of Charged Particle

    1998-10-01

    Preliminary results of carbon ion radiotherapy for the advanced head and neck cancer were reviewed. Local control rate of 49 patients at 36 months was 72.6% and survival rate of those was 54.3%. Local control rate of 14 cases with nasal and paranasal cancer was 60.5% and that of 8 cases with parotid gland tumor was 100%. Also local control rate of 16 adenoid cystic carcinoma was 75% at 36 months and that of 8 cases with malignant melanoma was 87.5%. These preliminary results will show the advantage of dose localization and the high RBE (relative biological effectiveness) characteristics of carbon ions relative to the conventional photon therapy. (author)

  12. Clinical analysis of 47 primary parotid cancers

    International Nuclear Information System (INIS)

    A retrospective study was performed on 47 patients with primary malignant neoplasms of the parotid gland treated in our department between 1982 and 1999. Most of the patients were male and over age 40, and 23 patients were of stage IV in clinical classification. The most frequently observed histological type was adenocarcinoma (12 patients), and the next was adenoid cystic carcinoma (11 patients). A radical parotidectomy with postoperative radiation therapy was administered in 38 patients, and palliative treatment in 9. The global survival rate was 74.1% at 5 years, and 89.4% in the patients treated with the radical procedure. Radical operative treatment and subsequent over 50-Gy of irradiation supposed to be the important factor to improve the prognosis. (author)

  13. Incidentally found and unexpected tumors discovered by MRI examination for temporomandibular joint arthrosis

    Energy Technology Data Exchange (ETDEWEB)

    Yanagi, Yoshinobu; Asaumi, Jun-ichi E-mail: asaumi@md.okayama-u.ac.jp; Maki, Yuu; Murakami, Jun; Hisatomi, Miki; Matsuzaki, Hidenobu; Konouchi, Hironobu; Honda, Yosutoshi; Kishi, Kanji

    2003-07-01

    We examined the frequency of incidentally found or unexpected tumors discovered at the time of magnetic resonance imaging (MRI) examinations in the temporomandibular joint (TMJ) region for patients with suspicion of TMJ arthrosis. Five MR images (T1-weighted transverse scout image and proton density and T2-weighted oblique sagittal images at the open and closed mouth) were acquired. In 2776 MRI examinations of TMJ arthrosis, two tumors were discovered. They consisted of an adenoid cystic carcinoma in the deep portion of the parotid gland, and a malignant tumor extending from the infratemporal fossa to the parapharyngeal space. The rate of incidentally founded or unexpected tumors in TMJ examinations was low (0.072%), but the two tumors found were malignant tumors, and therefore, scout image should be carefully examined, not only used for positing the slice.

  14. Transcriptome meta-analysis of lung cancer reveals recurrent aberrations in NRG1 and Hippo pathway genes.

    Science.gov (United States)

    Dhanasekaran, Saravana M; Balbin, O Alejandro; Chen, Guoan; Nadal, Ernest; Kalyana-Sundaram, Shanker; Pan, Jincheng; Veeneman, Brendan; Cao, Xuhong; Malik, Rohit; Vats, Pankaj; Wang, Rui; Huang, Stephanie; Zhong, Jinjie; Jing, Xiaojun; Iyer, Matthew; Wu, Yi-Mi; Harms, Paul W; Lin, Jules; Reddy, Rishindra; Brennan, Christine; Palanisamy, Nallasivam; Chang, Andrew C; Truini, Anna; Truini, Mauro; Robinson, Dan R; Beer, David G; Chinnaiyan, Arul M

    2014-01-01

    Lung cancer is emerging as a paradigm for disease molecular subtyping, facilitating targeted therapy based on driving somatic alterations. Here we perform transcriptome analysis of 153 samples representing lung adenocarcinomas, squamous cell carcinomas, large cell lung cancer, adenoid cystic carcinomas and cell lines. By integrating our data with The Cancer Genome Atlas and published sources, we analyse 753 lung cancer samples for gene fusions and other transcriptomic alterations. We show that higher numbers of gene fusions is an independent prognostic factor for poor survival in lung cancer. Our analysis confirms the recently reported CD74-NRG1 fusion and suggests that NRG1, NF1 and Hippo pathway fusions may play important roles in tumours without known driver mutations. In addition, we observe exon-skipping events in c-MET, which are attributable to splice site mutations. These classes of genetic aberrations may play a significant role in the genesis of lung cancers lacking known driver mutations. PMID:25531467

  15. A guide for radiological indications and major findings in medical practice

    International Nuclear Information System (INIS)

    If a clear cut diagnosis is reached by a simple modality such as adenoids by a nasopharynx radiograph; infection, sarcoidosis, or pneumothorax by a chest radiograph; stones in the gall-bladder, or cysts in a kidney by ultrasound; I cannot understand a need or an excuse for any further co sty, or invasive modalities. On the other hand, the single most valuable modality for epidural or subdural hematoma is CT and for multiple sclerosis or meniscal tear is MRI. Although the basic x rays for chest, bones and bowel loops in abdomen are still the most valuable standards, however the subject of modality of choice elsewhere in only applicable to instruments [X ray, US, CT and MR machines] manufactured at the same year and of latest generation. So the suggested modality of choice in this book is scientifically valid at year of publishing and can be subjected to any change in the future. (author)

  16. Radiographic anatomy and pathology of the child's airway

    International Nuclear Information System (INIS)

    The laryngotracheal airway has been considered the ''bottle-neck'' of the lungs. Any compromise of this already rather small pathway can easily result in a life-threatening situation. Rapid, accurate diagnosis is essential for proper clinical management of a compromised airway. Radiologic studies play a major role in the clinical investigation of patients with serious airway problems. There are notable differences between the anatomy of the upper airway of the adult and that of the young child or infant. In the infant, however, some differences in the radiographic patterns must be kept in mind. In the first 6 months of life, the adenoid shadow is not well defined and is normally absent until 1 month of age. During swallowing there is a lack of air in the pharynx with elevation of the larynx. Air may be seen in the cervical esophagus. All of these physiologic variations must be considered when interpreting radiographs of the neck in the young child

  17. Malignant tumors of nasal cavity: computed tomography evaluation; Tumores malignos da cavidade nasal: avaliacao por tomografia computadorizada

    Energy Technology Data Exchange (ETDEWEB)

    Mendonca, Vinicius Franca de; Carvalho, Antonio Carlos Pires [Universidade Federal, Rio de Janeiro, RJ (Brazil). Dept. de Radiologia; Freitas, Emilson [Instituto Nacional do Cancer, Rio de Janeiro, RJ (Brazil); Boasquevisque, Edson Mendes [Universidade do Estado, Rio de Janeiro, RJ (Brazil). Faculdade de Ciencias Medicas]. E-mail: boasque@uerj.br

    2005-05-15

    Objective: to review the computed tomography findings in patients with nasal cavity tumors. Materials and methods: eighteen patients - ten male and eight female - with nasal cavity tumors were studied using computed tomography. Results: histological types of the tumors included six epidermoid carcinoma, three malignant melanoma, two adenoid cystic carcinoma, and one case of each of the following: adenocarcinoma, undifferentiated carcinoma, neuroendocrine carcinoma, non-Hodgkin lymphoma, rhabdomyosarcoma, fusiform cell sarcoma, and stesioneuroblastoma. The lesions were more frequent on the left side and middle level of the nasal cavity (p > 0.05). Conclusion: epidermoid carcinomas showed a close relationship between the lesion volume and the degree of destruction of adjacent structures. Septum involvement was different depending on the histological type of the lesion. (author)

  18. Malignant tumors of nasal cavity: computed tomography evaluation

    International Nuclear Information System (INIS)

    Objective: to review the computed tomography findings in patients with nasal cavity tumors. Materials and methods: eighteen patients - ten male and eight female - with nasal cavity tumors were studied using computed tomography. Results: histological types of the tumors included six epidermoid carcinoma, three malignant melanoma, two adenoid cystic carcinoma, and one case of each of the following: adenocarcinoma, undifferentiated carcinoma, neuroendocrine carcinoma, non-Hodgkin lymphoma, rhabdomyosarcoma, fusiform cell sarcoma, and stesioneuroblastoma. The lesions were more frequent on the left side and middle level of the nasal cavity (p > 0.05). Conclusion: epidermoid carcinomas showed a close relationship between the lesion volume and the degree of destruction of adjacent structures. Septum involvement was different depending on the histological type of the lesion. (author)

  19. Factors affecting adenoidectomy for otitis media with effusion (glue ear).

    Science.gov (United States)

    Maw, A R

    1985-01-01

    One hundred and fifty-five children suffering bilateral otitis media with effusion (OME) and observed for three months have been followed postoperatively for twelve months. Surgery was randomly allocated into three groups: adenotonsillectomy; adenoidectomy; and no surgery. In all cases unilateral myringotomy and grommet insertion was performed. The contralateral unoperated ear was assessed subsequently for clearance of the effusion. Adenoidectomy produced resolution of the effusion in 31-45% of cases at one year, but tonsillectomy conferred no additional benefit. There was improved resolution in those with longer compared with shorter histories, and in older as opposed to younger children. Assessment of preoperative lateral cephalometric radiographs show improved resolution of the effusion following removal of larger, compared with smaller adenoids, but this effect was only demonstrable for three months. The effect of age was longer-lasting for up to one year postoperatively. PMID:4067973

  20. Remote afterloading high dose-rate intracavity radiotherapy for advanced maxillary cancer. Treatment with individual appliances

    International Nuclear Information System (INIS)

    Seven advanced maxillary cancers, 5 squamous cell carcinomas, and 2 adenoid cystic carcinomas were treated with remote afterloading high dose-rate intracavity radiotherapy. For treatment, we fabricated individual dental acrylic appliances for the postoperative area of the oral cavity. Because the appliance was specially matched to the remaining maxillary structures, radiation doses to the treated area were easily reproduced without distress to the patient. However, minor or major complications (moderate or severe mucositis and osteoradionecrosis) were observed in all patients. In this study, the number of patients was too small to assess the significance of this treatment. Nevertheless, with improvements, we think that remote afterloading high dose-rate intracavity radiotherapy with a dental acrylic appliance will soon be used to treat advanced maxillary carcinoma. (author)

  1. Does the type of rhinitis influence development of otitis media with effusion in children?

    Science.gov (United States)

    Quaranta, Nicola; Iannuzzi, Lucia; Gelardi, Matteo

    2014-11-01

    Otitis media with effusion (OME) is characterized by the presence of fluid in the middle ear cavity behind an intact eardrum and is considered a multifactorial condition with Eustachian tube dysfunction as the underlying pathophysiologic condition. One of the most debated causes of OME is allergy, in particular allergic rhinitis. The aim of this paper is to review the role of rhinitis in the development of OME and in particular the role of both allergic (AR) and non-allergic rhinitis (NAR). Most of the recent literature confirms the role of AR in the development of OME, while there are few reports on the role of NAR. In non-allergic children affected by obstructive adenoid hypertrophy, the presence of mast cells in the nasal smear was associated with a high risk of developing a chronic OME. PMID:25183363

  2. Gefitinib in Treating Patients With Metastatic or Unresectable Head and Neck Cancer or Non-Small Cell Lung Cancer

    Science.gov (United States)

    2013-01-11

    Anaplastic Thyroid Cancer; Insular Thyroid Cancer; Metastatic Parathyroid Cancer; Recurrent Adenoid Cystic Carcinoma of the Oral Cavity; Recurrent Basal Cell Carcinoma of the Lip; Recurrent Esthesioneuroblastoma of the Paranasal Sinus and Nasal Cavity; Recurrent Inverted Papilloma of the Paranasal Sinus and Nasal Cavity; Recurrent Lymphoepithelioma of the Nasopharynx; Recurrent Lymphoepithelioma of the Oropharynx; Recurrent Metastatic Squamous Neck Cancer With Occult Primary; Recurrent Midline Lethal Granuloma of the Paranasal Sinus and Nasal Cavity; Recurrent Mucoepidermoid Carcinoma of the Oral Cavity; Recurrent Non-small Cell Lung Cancer; Recurrent Parathyroid Cancer; Recurrent Salivary Gland Cancer; Recurrent Squamous Cell Carcinoma of the Hypopharynx; Recurrent Squamous Cell Carcinoma of the Larynx; Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity; Recurrent Squamous Cell Carcinoma of the Nasopharynx; Recurrent Squamous Cell Carcinoma of the Oropharynx; Recurrent Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity; Recurrent Thyroid Cancer; Recurrent Verrucous Carcinoma of the Larynx; Stage III Follicular Thyroid Cancer; Stage III Papillary Thyroid Cancer; Stage III Salivary Gland Cancer; Stage III Squamous Cell Carcinoma of the Hypopharynx; Stage III Squamous Cell Carcinoma of the Larynx; Stage III Verrucous Carcinoma of the Larynx; Stage IIIB Non-small Cell Lung Cancer; Stage IV Lymphoepithelioma of the Nasopharynx; Stage IV Non-small Cell Lung Cancer; Stage IV Squamous Cell Carcinoma of the Hypopharynx; Stage IV Squamous Cell Carcinoma of the Nasopharynx; Stage IVA Adenoid Cystic Carcinoma of the Oral Cavity; Stage IVA Basal Cell Carcinoma of the Lip; Stage IVA Esthesioneuroblastoma of the Paranasal Sinus and Nasal Cavity; Stage IVA Follicular Thyroid Cancer; Stage IVA Inverted Papilloma of the Paranasal Sinus and Nasal Cavity; Stage IVA Lymphoepithelioma of the Oropharynx; Stage IVA Midline Lethal Granuloma of the Paranasal Sinus and Nasal Cavity; Stage IVA Mucoepidermoid Carcinoma of the Oral Cavity; Stage IVA Papillary Thyroid Cancer; Stage IVA Salivary Gland Cancer; Stage IVA Squamous Cell Carcinoma of the Larynx; Stage IVA Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage IVA Squamous Cell Carcinoma of the Oropharynx; Stage IVA Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity; Stage IVA Verrucous Carcinoma of the Larynx; Stage IVA Verrucous Carcinoma of the Oral Cavity; Stage IVB Adenoid Cystic Carcinoma of the Oral Cavity; Stage IVB Basal Cell Carcinoma of the Lip; Stage IVB Esthesioneuroblastoma of the Paranasal Sinus and Nasal Cavity; Stage IVB Follicular Thyroid Cancer; Stage IVB Inverted Papilloma of the Paranasal Sinus and Nasal Cavity; Stage IVB Lymphoepithelioma of the Oropharynx; Stage IVB Midline Lethal Granuloma of the Paranasal Sinus and Nasal Cavity; Stage IVB Mucoepidermoid Carcinoma of the Oral Cavity; Stage IVB Papillary Thyroid Cancer; Stage IVB Salivary Gland Cancer; Stage IVB Squamous Cell Carcinoma of the Larynx; Stage IVB Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage IVB Squamous Cell Carcinoma of the Oropharynx; Stage IVB Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity; Stage IVB Verrucous Carcinoma of the Larynx; Stage IVB Verrucous Carcinoma of the Oral Cavity; Stage IVC Adenoid Cystic Carcinoma of the Oral Cavity; Stage IVC Basal Cell Carcinoma of the Lip; Stage IVC Esthesioneuroblastoma of the Paranasal Sinus and Nasal Cavity; Stage IVC Follicular Thyroid Cancer; Stage IVC Inverted Papilloma of the Paranasal Sinus and Nasal Cavity; Stage IVC Lymphoepithelioma of the Oropharynx; Stage IVC Midline Lethal Granuloma of the Paranasal Sinus and Nasal Cavity; Stage IVC Mucoepidermoid Carcinoma of the Oral Cavity; Stage IVC Papillary Thyroid Cancer; Stage IVC Salivary Gland Cancer; Stage IVC Squamous Cell Carcinoma of the Larynx; Stage IVC Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage IVC Squamous Cell Carcinoma of the Oropharynx; Stage IVC Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity;

  3. Osteopontin expression in salivary gland carcinomas

    DEFF Research Database (Denmark)

    BjØrndal, Kristine; Larsen, Stine R

    2011-01-01

    J Oral Pathol Med (2010) Background:? In several cancer types, osteopontin (OPN) expression has been correlated with tumor progression and prognosis. Two earlier studies have examined OPN expression in salivary gland carcinomas with contradictory results. Methods:? One hundred and seventy-five patients with a primary salivary gland carcinoma diagnosed from January 1, 1990 to December 31, 2005 were identified in the local pathology register, Odense University Hospital. Criteria as documented by Allred et al. were used to assess OPN immunostaining that was performed on surgical specimens. Results:? Osteopontin was expressed in all salivary gland carcinomas. Adenoid cystic carcinomas had the highest mean sum score (7.3) and a significantly higher proportion of carcinomas with high OPN sum score than both mucoepidermoid carcinoma and acinic cell carcinoma. Correlation of OPN expression with known prognostic factors in salivary gland carcinomas was insignificant. Conclusions:? Salivary gland carcinomas express OPN. The expression does not correlate with known prognostic factors.

  4. Reactional Plasmacytosis In Plasma Cell Orificial mucositis In A Patient Of Pulmonary Tuberculosis

    Directory of Open Access Journals (Sweden)

    Bose Sumit Kumar

    1997-01-01

    Full Text Available Skin biopsy of a 50 year old Moroccan male patient with labial and oro-pharyngeal plasmocytosis showed hyperplastic, with papillomatous eroded epithelium. Dense infiltrates of plasma cells were seen in the dermis, with perivascular prominence. Hypopharynx, epiglottis, adenoids, and tonsils showed the same type of infiltration. Immunofluorescence (IF and peroxidase antiperoxidase (PAP techniques demonstrated the presence of mostly and infiltrate of plasma cells showing IgA (30 â€" 40%, IgM (20-30%, IgG(10-20% after staining with polyclonal antibodies along with T4 & T8 Iymphocytes with monoclonal staining. Electron microscopy showed absence of atypical plasma cells with abundant endoplasmic reticulum. Patientâ€?s symptoms of stomtitis, dysphonia and pharyngitis were temporarily relieved by systemic corticosteroids of plasma cells suggesting a reactive type of benign plasmocytosis.

  5. Protruded superficial esophageal carcinoma

    International Nuclear Information System (INIS)

    Until the end of 1985, 113 cases of superficial esophageal carcinoma had been operated on. Classified by histology, almost all cases are squamous cell carcinoma and some cases are pseudocarcinoma, adenocarcinoma, adenoid cystic carcinoma, basal cell carcinoma and so on. X-ray of the latter shows all cases except one are protruded type. Regarding the relation between X-ray findings and histology, semipeduncular tumorous type, generally speaking, belongs to pseudosarcoma. As to lymph node metastasis, there is no difference among superficial elevated, tumorous elevated and semi-peduncular tumorous types. Lymph node metastasis is less freqently seen in the cases with smooth surface. With regard to prognosis, there is no difference between early carcinoma without lymph node metastasis and superficial carcinoma with lymph node metastasis. Only two-year and more than 7-year survival rates of the one with smooth surface are superior to those of the one with irregular surface. (author)

  6. Undifferentiated salivary gland carcinomas

    DEFF Research Database (Denmark)

    Herbst, H.; Hamilton-Dutoit, S.

    2004-01-01

    Undifferentiated salivary gland carcinomas may be divided into small cell and large cell types. Among large cell undifferentiated carcinomas, lymphoepithelial carcinomas have to be distinguished, the latter of which are endemic in the Arctic regions and southern China where virtually all cases of these tumors are associated with the Epstein-Barr virus (EBV). Association with EBV may also be observed in sporadic cases, and detection of EBV gene products may aid their diagnosis. Immunohistology may be employed to resolve the differential diagnosis of undifferentiated salivary gland carcinomas, comprising malignant lymphomas, amelanotic melanomas, Merkel cell carcinomas, and adenoid cystic carcinomas, in particular in small biopsy materials. Because of the rarity of undifferentiated salivary gland carcinomas, the differential diagnosis should always include metastases of undifferentiated carcinomas arising at other primary sites, particularly when expressing the thyroid transcription factor-1 (TTF-1) Udgivelsesdato: 2004

  7. Fission neutron therapy at FRM II: Indications and first results

    International Nuclear Information System (INIS)

    Based on 15 years of experience with neutron therapy at the former facility at Munich research reactor FRM, fast neutron therapy with fission neutrons of FRM II is performed at the new facility MedApp since June 2007. General indications are superficially located tumors with insufficient response to conventional radiotherapy. Until August 2009, 58 patients were treated, 25% of them with curative intention (adenoid cystic carcinoma of major salivary glands, malignant melanoma, sarcoma). The most frequent palliative indications were breast wall recurrences of breast cancer and skin or lymph node recurrences of squamous cell carcinomas, resulting in response rates of 84% and 42%, respectively. Short treatment times of fast neutron therapy (3-5 fractions in 2-3 weeks) are advantageous in palliative treatment strategies.

  8. Bevacizumab in Reducing CNS Side Effects in Patients Who Have Undergone Radiation Therapy to the Brain for Primary Brain Tumor, Meningioma, or Head and Neck Cancer

    Science.gov (United States)

    2014-04-21

    Adult Anaplastic Astrocytoma; Adult Anaplastic Ependymoma; Adult Anaplastic Meningioma; Adult Anaplastic Oligodendroglioma; Adult Brain Stem Glioma; Adult Central Nervous System Germ Cell Tumor; Adult Choroid Plexus Tumor; Adult Diffuse Astrocytoma; Adult Ependymoma; Adult Grade II Meningioma; Adult Grade III Meningioma; Adult Malignant Hemangiopericytoma; Adult Mixed Glioma; Adult Oligodendroglioma; Adult Papillary Meningioma; Adult Pineocytoma; Malignant Neoplasm; Meningeal Melanocytoma; Radiation Toxicity; Recurrent Adenoid Cystic Carcinoma of the Oral Cavity; Recurrent Adult Brain Tumor; Recurrent Basal Cell Carcinoma of the Lip; Recurrent Esthesioneuroblastoma of the Paranasal Sinus and Nasal Cavity; Recurrent Inverted Papilloma of the Paranasal Sinus and Nasal Cavity; Recurrent Lymphoepithelioma of the Nasopharynx; Recurrent Lymphoepithelioma of the Oropharynx; Recurrent Midline Lethal Granuloma of the Paranasal Sinus and Nasal Cavity; Recurrent Mucoepidermoid Carcinoma of the Oral Cavity; Recurrent Salivary Gland Cancer; Recurrent Squamous Cell Carcinoma of the Hypopharynx; Recurrent Squamous Cell Carcinoma of the Larynx; Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity; Recurrent Squamous Cell Carcinoma of the Nasopharynx; Recurrent Squamous Cell Carcinoma of the Oropharynx; Recurrent Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity; Recurrent Verrucous Carcinoma of the Larynx; Recurrent Verrucous Carcinoma of the Oral Cavity; Stage I Adenoid Cystic Carcinoma of the Oral Cavity; Stage I Basal Cell Carcinoma of the Lip; Stage I Esthesioneuroblastoma of the Paranasal Sinus and Nasal Cavity; Stage I Inverted Papilloma of the Paranasal Sinus and Nasal Cavity; Stage I Lymphoepithelioma of the Nasopharynx; Stage I Lymphoepithelioma of the Oropharynx; Stage I Midline Lethal Granuloma of the Paranasal Sinus and Nasal Cavity; Stage I Mucoepidermoid Carcinoma of the Oral Cavity; Stage I Salivary Gland Cancer; Stage I Squamous Cell Carcinoma of the Hypopharynx; Stage I Squamous Cell Carcinoma of the Larynx; Stage I Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage I Squamous Cell Carcinoma of the Nasopharynx; Stage I Squamous Cell Carcinoma of the Oropharynx; Stage I Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity; Stage I Verrucous Carcinoma of the Larynx; Stage I Verrucous Carcinoma of the Oral Cavity; Stage III Adenoid Cystic Carcinoma of the Oral Cavity; Stage III Basal Cell Carcinoma of the Lip; Stage III Esthesioneuroblastoma of the Paranasal Sinus and Nasal Cavity; Stage III Inverted Papilloma of the Paranasal Sinus and Nasal Cavity; Stage III Lymphoepithelioma of the Nasopharynx; Stage III Midline Lethal Granuloma of the Paranasal Sinus and Nasal Cavity; Stage III Mucoepidermoid Carcinoma of the Oral Cavity; Stage III Salivary Gland Cancer; Stage III Squamous Cell Carcinoma of the Hypopharynx; Stage III Squamous Cell Carcinoma of the Larynx; Stage III Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage III Squamous Cell Carcinoma of the Nasopharynx; Stage III Squamous Cell Carcinoma of the Oropharynx; Stage III Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity; Stage III Verrucous Carcinoma of the Larynx; Stage III Verrucous Carcinoma of the Oral Cavity; Stage IV Adenoid Cystic Carcinoma of the Oral Cavity; Stage IV Basal Cell Carcinoma of the Lip; Stage IV Esthesioneuroblastoma of the Paranasal Sinus and Nasal Cavity; Stage IV Inverted Papilloma of the Paranasal Sinus and Nasal Cavity; Stage IV Lymphoepithelioma of the Nasopharynx; Stage IV Lymphoepithelioma of the Oropharynx; Stage IV Midline Lethal Granuloma of the Paranasal Sinus and Nasal Cavity; Stage IV Mucoepidermoid Carcinoma of the Oral Cavity; Stage IV Salivary Gland Cancer; Stage IV Squamous Cell Carcinoma of the Hypopharynx; Stage IV Squamous Cell Carcinoma of the Larynx; Stage IV Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage IV Squamous Cell Carcinoma of the Nasopharynx; Stage IV Squamous Cell Carcinoma of the Oropharynx; Stage IV Squamous Cell Carcinoma of the Paranasal

  9. Management of difficult airway in intratracheal tumor surgery

    Directory of Open Access Journals (Sweden)

    Agarwal Surendra K

    2005-06-01

    Full Text Available Abstract Background Tracheal malignancies are usual victim of delay in diagnosis by virtue of their symptoms resembling asthma. Sometimes delayed diagnosis may lead to almost total airway obstruction. For difficult airways, not leaving any possibility of manipulation into neck region or endoscopic intervention, femorofemoral cardiopulmonary bypass can be a promising approach. Case Presentation We are presenting a case of tracheal adenoid cystic carcinoma (cylindroma occupying about 90% of the tracheal lumen. It was successfully managed by surgical excision of mass by sternotomy and tracheotomy under femorofemoral cardiopulmonary bypass (CPB. Conclusion Any patient with recurrent respiratory symptoms should be evaluated by radiological and endoscopic means earlier to avoid delay in diagnosis of such conditions. Femorofemoral cardiopulmonary bypass is a relatively safe way of managing certain airway obstructions.

  10. A case of presumed radiation optic neuropathy

    International Nuclear Information System (INIS)

    A case of a 37-year-old woman with radiation optic neuropathy was reported. She had undergone subtotal removal of the right orbital tumor (adenoid cystic carcinoma) by frontal craniotomy, followed by radiation therapy (64 Gy). She had been quite well until she noticed a gradual loss of vision in her right eye 18 months later. Her visual acuity was 0.2 in the right eye and 1.5 in the left eye with right relative afferent pupillary defect and dense central scotoma. Funduscopy revealed optic disc swelling with surrounding retinal edema and small hemorrhage in the right eye. Fluorescein angiography revealed a hypoperfusion area and obstruction of the small retinal vessels in the posterior pole, but this was not large enough to explain the dense central scotoma. Although prednisolone therapy gave temporary improvement, the visual function gradually deteriorated. (author)

  11. Benefits of maxillectomy with internal dissection of the masticator space by transmandibular approach in the surgical management of malignant tumours of the upper gingiva and hard palate: a clinical review of 10 cases.

    Science.gov (United States)

    Yanamoto, S; Yamada, S; Takahashi, H; Naruse, T; Shigeta, T; Minamikawa, T; Shibuya, Y; Komori, T; Umeda, M

    2014-11-01

    The aim of this study was to review patients with tumours extending to the posterior portion of the upper gingiva and hard palate, and to evaluate the postoperative outcomes. Ten consecutive patients with tumours in the upper gingiva and hard palate, who underwent maxillectomy with internal dissection of the masticator space by the transmandibular approach, were reviewed retrospectively. Among the 10 patients, the pathological diagnosis was squamous cell carcinoma in seven, adenoid cystic carcinoma in one, malignant melanoma in one, and osteosarcoma in one. Loco-regional control was achieved in eight of nine patients (88.9%). Three patients had residual moderate trismus. Cosmetic issues were not noted in any patient. En bloc resection of the maxilla with the internal portion of the masticator space and neck through the parapharyngeal space by the transmandibular approach is a useful and satisfactory technique for the excision of a tumour with involvement of the posterior portion of the upper gingiva and hard palate. PMID:24993866

  12. Retrievable Airway Stent Placement for Stoma Stricture after Anterior Mediastinal Tracheostomy: Case Report

    Energy Technology Data Exchange (ETDEWEB)

    Hwang, Jae Yeon; Shin, Ji Hoon; Kim, Yong Hee; Song, Ho Young; Kim, Jin Hyoung [Dept. of University of Ulsan College of Medicine, Asan Medical Center, Seoul (Korea, Republic of); Lee, Yeoun Joo [Dept. of Pediatrics, Pusan National University Children' s Hospital, Yangsan (Korea, Republic of)

    2013-06-15

    Anterior mediastinal tracheostomy (AMT) is performed to establish an airway after resection of advanced tumors in the cervicothoracic region. We report a case of successful placement of a covered retrievable self-expandable nitinol stent for a stoma stricture that developed after AMT in a patient with adenoid cystic carcinoma of the trachea. Two stent placements and removals, at two and three months after their initial placement, were performed due to loosening of the stents. Although we did not achieve long-term results as the patient died of massive hemorrhage, the stent placement was both feasible and safe, thus suggesting that temporary stent placement may be a valuable option for treating stoma stricture occurring after AMT.

  13. The impact of social and environmental changes on allergic rhinitis among Saudi children. A clinical and allergological study.

    Science.gov (United States)

    al Anazy, F H; Zakzouk, S M

    1997-10-18

    Eighty four children with allergic rhinitis out of 316 consecutive cases were investigated, treated and followed-up for 2 years. Diagnostic skin testing were done with identified common allergens found in Saudi environment (2). Cat fur, Bermuda grass and mesquite were the most common allergens found. Symptoms of recurrent rhinosinusitis, otitis media with effusion, tonsils and adenoids infection were commonly noticed among them. The rapid change of environment in Saudi Arabia in the form of agricultural and other factors seem to play part in the increasing incidence of allergic manifestation in paediatric population. With antiallergic treatment and control of infection, most of these children responded well and only four children required surgery. The treatment of allergic disease saves a lot of children from unnecessary surgical procedures usually carried out on them. PMID:9477347

  14. Adenoma de células basales de glándula parótida: Caso clínico y revisión de la literatura / Basal cell adenoma of the parotid gland: Case report and review of the literature

    Scientific Electronic Library Online (English)

    Raúl, González García; Syong H., Nam Cha; Mario F., Muñoz Guerra; C., Gamallo Amat.

    2006-04-01

    Full Text Available El adenoma de células basales de las glándulas salivares es un tipo de adenoma monomorfo de aparición infrecuente. La localización más habitual es la superficie de la glándula parótida. Suele debutar clínicamente como una masa firme y desplazable de crecimiento lento. Histológicamente se observan cé [...] lulas isomórficas formando nidos y trabéculas interanastomosadas, con una membrana basal prominente, separadas por un estroma laxo e hialino y ausencia de estroma mixoide o condroide. A diferencia del adenoma pleomorfo, tiende a la multicentricidad y su tasa de recurrencia después de la extirpación quirúrgica es alta. Debido a sus implicaciones pronósticas, el diagnóstico diferencial con el adenocarcinoma de células basales, el carcinoma adenoide quístico y el carcinoma de células escamosas basalioide es prioritario. Describimos un caso clínico de adenoma de células basales de la glándula parótida, realizamos una revisión de la literatura y discutimos el manejo diagnóstico y terapéutico de esta rara entidad. Abstract in english Basal cell adenoma of the salivary glands is an uncommon type of monomorphous adenoma. Its most frequent location is the parotid gland. It usually appears as a firm and mobile slow-growing mass. Histologically, isomorphic cells in nests and interlaced trabecules with a prominent basal membrane are o [...] bserved. It is also characterized by the presence of a slack and hyaline stroma and the absence of myxoid or condroid stroma. In contrast to pleomorphic adenoma, it tends to be multiple and its recurrence rate after surgical excision is high. Due to prognostic implications, differential diagnosis with basal cell adenocarcinoma, adenoid cystic carcinoma and basaloid squamous cell carcinoma is mandatory. We describe a case of basal cell adenoma of the parotid gland. We also review the literature and discuss the diagnosis and management of this rare entity.

  15. Fractionated stereotactic radiation therapy for extracranial head and neck tumors

    International Nuclear Information System (INIS)

    Background: This study is to report the clinical experiences of fractionated stereotactic radiation therapy (FSRT) for extracranial head and neck tumors. Methods and Materials: Between the period of July 1995 and November 1998, 48 patients with extracranial head and neck tumors were given FSRT as a boost and sole modality. Individualized treatment planning was performed using XKnife-3 system with relocatable Gill-Thomas-Cosman frame. In 24 patients, FSRT was applied as a boost technique following the 2-dimensional conventional external radiation therapy (ERT); in 24 patients FSRT was the sole radiotherapy modality. The primary diseases in the boost group consisted of nasopharynx cancer (19), lacrimal gland adenoid cystic carcinoma (3), orbital lymphoma (1), and skull-base recurrence of maxillary sinus adenoid cystic carcinoma (1). The primary diseases in the sole modality group consisted of recurrent nasopharynx cancer (12), orbital pseudotumor (4), skull-base recurrence of maxillary sinus, submandibular gland, and hypopharynx cancers (3), orbital rhabdomyosarcoma (2), orbital lymphoma (1), orbital metastasis of neuroblastoma (1), and nasal cavity melanoma (1). The fractionation schedule was to give 5 treatments per one week and the fractional doses were 2.0-3 Gy depending on the treatment aim and the FSRT volume. The FSRT doses varied depending on the nature of the primary diseases. Results: The local tumor response in nasopharynx cancer patients was excellent compararynx cancer patients was excellent compared to retrospective data without occurrence of unexpectedly severe complication. FSRT to other regions was well tolerated by the patients and resulted in good to excellent local tumor responses with no unacceptable side effects as expected by the authors. Conclusion: Based on the current observations, FSRT is a very effective and safe modality in the treatment of extracranial head and neck tumors

  16. Etude epidemilogique du syndrome des ovaires micropolykystiques a l'Hopital Bonzola de MbujiMayi , Congo (RDC

    Directory of Open Access Journals (Sweden)

    Mbuyamba NKL

    2012-09-01

    Full Text Available Objectif Définir le Profil épidémiologique de la femme avec le SOMPK à l'hôpital BONZOLA de Mbuji-Mayi et d'identifier dans ce milieu les éléments diagnostiques du SOMPK. Méthodes De 1260 patientes ayant présenté les signes cliniques observés dans le SOMPK, l'échographie a confirmé le SOMPK chez 315 patientes en se basant sur les critères retenus par la conférence de consensus de Rotterdam de 2003. Résultats La fréquence de SOMPK est de 25% dans cet hôpital. L'âge de ces patientes a varié entre 15 et 45 ans avec un âge moyen de 28 ans ±3ans. Leur parité moyenne est de ±1. L'analyse des circonstances de diagnostic a révélé que les troubles menstruels (50%, l'infertilité (31% et le bilan de santé annuelle pour la femme travailleuse (15% ont constitué les motifs de consultation. Les signes cliniques et échographiques observés lors de diagnostic de SOMPK sont la spanioménorrhée (74,6%, l'hirsutisme (81,9%, l'obésité androïde (54%, l'infertilité' (49,5%, la surface ovarienne augmentée de volume (100% et les microkystes de 10 à 20 de nombre et de diamètre inférieur à 9mm repartis en périphérie (100%. Conclusion La fréquence très élevée du SOMPK dans ce milieu incite à entreprendre une étude approfondie pour déterminer des facteurs de risque du syndrome des ovaires micro kystiques . AbstractAimsTo define the epidemiological profile of women with PCOS at the BONZOLA hospital of Mbuji-Mayi and to identify in our setting the diagnostic cues of the PCOS . Methods Of 1260 patients who presented the clinical signs observed in the PCOS, an ultrasound (or sonography confirmed the presence of polycystic ovaries in 315 patients based on the criteria reached by the conference on consensus held in Rotterdam in 2003 . Results The frequency of PCOS is of 25% in the Bonzola hospital. The age of the patients varied between 15 and 45 years with a mean age of 28 years ±3ans. Their mean parity is 1 ± 1 The analysis of the diagnostic symptoms and the reasons for consultation revealed menstrual irregularities in 50%, infertility in 31% and the annual check-up for the working woman was 15%. The clinical signs and the ultrasonographic image observed at the time of diagnosis of PCOS are spaniomenorrhea (74,6%, hirsutism (81,9%, android obesity (54%, infertility' (49,5%, increased ovarian volume (100% and peripheral ovarian cysts, in numbers of 10 to 20 and diameter of less than 9mm (100%. Conclusion The high frequency of the PCOS in our setting suggests the need for a more profound study of the patients with these symptoms to prevent the multiple complications of this pathology.

  17. Erlotinib and Cetuximab With or Without Bevacizumab in Treating Patients With Metastatic or Unresectable Kidney, Colorectal, Head and Neck, Pancreatic, or Non-Small Cell Lung Cancer

    Science.gov (United States)

    2014-06-10

    Metastatic Squamous Neck Cancer With Occult Primary Squamous Cell Carcinoma; Recurrent Adenoid Cystic Carcinoma of the Oral Cavity; Recurrent Basal Cell Carcinoma of the Lip; Recurrent Colon Cancer; Recurrent Esthesioneuroblastoma of the Paranasal Sinus and Nasal Cavity; Recurrent Inverted Papilloma of the Paranasal Sinus and Nasal Cavity; Recurrent Lymphoepithelioma of the Nasopharynx; Recurrent Lymphoepithelioma of the Oropharynx; Recurrent Metastatic Squamous Neck Cancer With Occult Primary; Recurrent Midline Lethal Granuloma of the Paranasal Sinus and Nasal Cavity; Recurrent Mucoepidermoid Carcinoma of the Oral Cavity; Recurrent Non-small Cell Lung Cancer; Recurrent Pancreatic Cancer; Recurrent Rectal Cancer; Recurrent Salivary Gland Cancer; Recurrent Squamous Cell Carcinoma of the Hypopharynx; Recurrent Squamous Cell Carcinoma of the Larynx; Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity; Recurrent Squamous Cell Carcinoma of the Nasopharynx; Recurrent Squamous Cell Carcinoma of the Oropharynx; Recurrent Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity; Recurrent Verrucous Carcinoma of the Larynx; Recurrent Verrucous Carcinoma of the Oral Cavity; Stage III Adenoid Cystic Carcinoma of the Oral Cavity; Stage III Basal Cell Carcinoma of the Lip; Stage III Colon Cancer; Stage III Esthesioneuroblastoma of the Paranasal Sinus and Nasal Cavity; Stage III Inverted Papilloma of the Paranasal Sinus and Nasal Cavity; Stage III Lymphoepithelioma of the Nasopharynx; Stage III Lymphoepithelioma of the Oropharynx; Stage III Midline Lethal Granuloma of the Paranasal Sinus and Nasal Cavity; Stage III Mucoepidermoid Carcinoma of the Oral Cavity; Stage III Pancreatic Cancer; Stage III Rectal Cancer; Stage III Salivary Gland Cancer; Stage III Squamous Cell Carcinoma of the Hypopharynx; Stage III Squamous Cell Carcinoma of the Larynx; Stage III Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage III Squamous Cell Carcinoma of the Nasopharynx; Stage III Squamous Cell Carcinoma of the Oropharynx; Stage III Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity; Stage III Verrucous Carcinoma of the Larynx; Stage III Verrucous Carcinoma of the Oral Cavity; Stage IIIB Non-small Cell Lung Cancer; Stage IV Adenoid Cystic Carcinoma of the Oral Cavity; Stage IV Basal Cell Carcinoma of the Lip; Stage IV Colon Cancer; Stage IV Esthesioneuroblastoma of the Paranasal Sinus and Nasal Cavity; Stage IV Inverted Papilloma of the Paranasal Sinus and Nasal Cavity; Stage IV Lymphoepithelioma of the Nasopharynx; Stage IV Lymphoepithelioma of the Oropharynx; Stage IV Midline Lethal Granuloma of the Paranasal Sinus and Nasal Cavity; Stage IV Mucoepidermoid Carcinoma of the Oral Cavity; Stage IV Non-small Cell Lung Cancer; Stage IV Pancreatic Cancer; Stage IV Rectal Cancer; Stage IV Renal Cell Cancer; Stage IV Salivary Gland Cancer; Stage IV Squamous Cell Carcinoma of the Hypopharynx; Stage IV Squamous Cell Carcinoma of the Larynx; Stage IV Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage IV Squamous Cell Carcinoma of the Nasopharynx; Stage IV Squamous Cell Carcinoma of the Oropharynx; Stage IV Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity; Stage IV Verrucous Carcinoma of the Larynx; Stage IV Verrucous Carcinoma of the Oral Cavity; Untreated Metastatic Squamous Neck Cancer With Occult Primary

  18. High dose-rate brachytherapy as a treatment option in primary tracheal tumors / Braquiterapia de alta taxa de dose como opção terapêutica nos tumores primários da traquéia

    Scientific Electronic Library Online (English)

    Heloisa de Andrade, Carvalho; Viviane, Figueiredo; Wilson Leite, Pedreira Jr.; Salim, Aisen.

    2005-08-01

    Full Text Available SciELO Brazil | Language: English Abstract in portuguese OBJETIVO: Apresentar a experiência do tratamento de 4 pacientes com tumores primários de traquéia, não operados, submetidos à braquiterapia endobrônquica de alta taxa de dose. PACIENTES E MÉTODOS: Dois casos de carcinoma espinocelular, uma recidiva de carcinoma adenóide cístico e uma recidiva de pla [...] smocitoma primário da traquéia. Todos receberam braquiterapia endobrônquica, exclusiva ou como reforço de dose da radioterapia externa. Foram administradas 3 ou 4 frações de 7,5 Gy cada, calculados a 1 cm de profundidade. O seguimento foi considerado a partir do término da braquiterapia. RESULTADOS: Em todos os casos houve resposta completa. Dois pacientes com carcinoma espinocelular evoluíram a óbito em 6 e 33 meses após a braquiterapia, o primeiro, sem evidência de doença e o outro por recidiva local, respectivamente. As outras 2 pacientes encontravam-se vivas após 64 e 110 meses de seguimento, sem evidência de doença. Esses 2 casos apresentaram estenose traqueal em 22 e 69 meses após a braquiterapia, sendo necessária a colocação de prótese traqueal apenas na paciente com carcinoma adenóide cístico. CONCLUSÕES: A braquiterapia endobrônquica de alta taxa de dose pode ser utilizada tanto como reforço de dose da irradiação externa quanto em recidivas. O controle local obtido em 3 de 4 pacientes indica que casos individuais podem se beneficiar desse procedimento. Sobrevida a longo prazo pode ser observada, principalmente nos casos de histologia adenóide cística. Abstract in english PURPOSE: To present experience with high dose-rate endobronchial brachytherapy in the treatment of primary tracheal tumors. PATIENTS AND METHODS: Four patients with nonresected primary tracheal tumors are presented: 2 cases of squamous cell carcinoma of the trachea, 1 of recurrent adenoid cystic car [...] cinoma, and 1 with recurrent plasmacytoma. All received brachytherapy, alone or as a boost for primary irradiation, in 3 or 4 fractions of 7.5 Gy, calculated at a depth of 1 cm. Follow-up was considered to start from the end of brachytherapy. RESULTS: Local control was achieved in all cases at the time of first bronchoscopic evaluation. Two patients with squamous cell carcinoma died at 6th and 33rd months after brachytherapy, respectively. The first had no evidence of disease, and the latter had local recurrence. The other 2 patients were alive after 64 and 110 months of follow-up, respectively, both with no evidence of disease. Tracheal stenosis developed in these 2 cases, 22 and 69 months after brachytherapy. Tracheal stent placement was needed only for the patient with an adenoid cystic carcinoma. CONCLUSIONS: Endobronchial high dose-rate brachytherapy may be used for tracheal tumors, even as a boost for external beam irradiation, or in recurrences. Local control in 3 out of 4 patients indicates that individual cases may benefit from the treatment. Long-term survival may also be expected, mainly for tumors with adenoid cystic histology.

  19. Otorrinolaringologia pediátrica no Sistema Público de Saúde de Belo Horizonte Pediatric (Otolaryngology at the Public Health System of a city in Southeastern Brazil

    Directory of Open Access Journals (Sweden)

    Angela Francisca Marques Guerra

    2007-10-01

    Full Text Available OBJETIVO: Analisar a adequação dos encaminhamentos da atenção primária para a secundária em otorrinolaringologia pediátrica. MÉTODOS: Estudo realizado em Belo Horizonte, estado de Minas Gerais, de março de 2004 a maio de 2005. Foram avaliadas 408 crianças pré-escolares encaminhadas da atenção primária para a secundária do setor de otorrinolaringologia com otite, faringoamigdalite, rinossinusite, rinite alérgica e hipertrofia de amígdala/adenóide. As variáveis analisadas foram: concordância dos diagnósticos na atenção primária e secundária, tempo de espera pela consulta, acompanhamento e especialista (médico de família ou pediatra que examinou a criança na atenção primária. A concordância dos diagnósticos foi avaliada pela análise estatística de kappa. RESULTADOS: Os pacientes tinham em média cinco anos de idade, dos quais 214 (52,5% eram meninos, o tempo médio de espera pela consulta foi de 3,7 meses. Os diagnósticos na atenção primária e secundária foram, respectivamente: otite (44%, 49%, hipertrofia de amígdala/adenóide (22%, 33%, faringoamigdalite (18%, 23%, rinossunusite (13%, 21%, rinite alérgica (3%, 33%. Análise de concordância kappa foi 0,15 para otite com efusão, 0,35 para otite recorrente, 0,04 para hipertrofia de amígdala/adenóide, 0,43 para faringoamigdalite, 0,05 para rinite alérgica; 0,2 para rinossinusite. Os diagnósticos na atenção primária para encaminhamento à secundária, definidos pelo médico de família ou pelo pediatra que avaliou a criança foram concordantes. CONCLUSÕES: A inadequação dos encaminhamentos da atenção primária para a secundária em otorrinolaringologia foi expressa pelo longo tempo de espera pela consulta e pela baixa concordância de diagnósticos firmados entre os níveis de atenção para os mesmos pacientes avaliados. A atenção primária poderia se tornar mais eficiente se os profissionais fossem mais bem capacitados em otorrinolaringologia.OBJECTIVE: To assess the suitability of referral from primary to secondary care in pediatric Otolaryngology. METHODS: The study was performed in the city of Belo Horizonte, in the state of Minas Gerais, from March 2004 to May 2005. A total of 408 pre-school children referred from primary care to secondary care in the department of Otolaryngology presenting with otitis, tonsillitis, sinusitis, allergic rhinitis, and tonsillar/adenoidal hypertrophy was assessed. The studied variables were: agreement between diagnoses in primary and secondary care; waiting time for doctor's appointment; follow-up, and professional (pediatrician or family physician that examined children in primary care. Agreement of diagnoses was assessed using kappa statistics. RESULTS: Patients were five years old on average, 214 (52.5% were boys, mean waiting time for appointment was 3.7 months. Diagnoses in primary and secondary care were respectively: otitis (44%, 49%, tonsillar/adenoidal hypertrophy (22%, 33%, tonsillitis (18%, 23%, sinusitis (13%, 21%, allergic rhinitis (3%, 33%. Agreement analysis of kappa was 0.15 for otitis with effusion, 0.35 for recurrent otitis, 0.04 for tonsillar/adenoidal hypertrophy, 0.43 for tonsillitis, 0.05 for allergic rhinitis, and 0.2 for sinusitis. Diagnoses in primary care referred to secondary care were in agreement when given either by pediatrician or family physician. CONCLUSIONS: Unsuitability of referrals from primary to secondary care in otolaryngology was expressed by the long time waiting for appointments and by the low agreement between diagnoses in different level of care for the same patients. Primary health care could be more efficient if professionals were better qualified in Otolaryngology.

  20. Scientific Electronic Library Online (English)

    Angela Francisca Marques, Guerra; Denise Utsch, Gonçalves; Maria da Conceição Juste Werneck, Côrtes; Claudia Regina Lindgren, Alves; Tânia Mara Assis, Lima.

    2007-10-01

    Full Text Available SciELO Public Health and Brazil | Languages: English, Portuguese Abstract in portuguese OBJETIVO: Analisar a adequação dos encaminhamentos da atenção primária para a secundária em otorrinolaringologia pediátrica. MÉTODOS: Estudo realizado em Belo Horizonte, estado de Minas Gerais, de março de 2004 a maio de 2005. Foram avaliadas 408 crianças pré-escolares encaminhadas da atenção primár [...] ia para a secundária do setor de otorrinolaringologia com otite, faringoamigdalite, rinossinusite, rinite alérgica e hipertrofia de amígdala/adenóide. As variáveis analisadas foram: concordância dos diagnósticos na atenção primária e secundária, tempo de espera pela consulta, acompanhamento e especialista (médico de família ou pediatra) que examinou a criança na atenção primária. A concordância dos diagnósticos foi avaliada pela análise estatística de kappa. RESULTADOS: Os pacientes tinham em média cinco anos de idade, dos quais 214 (52,5%) eram meninos, o tempo médio de espera pela consulta foi de 3,7 meses. Os diagnósticos na atenção primária e secundária foram, respectivamente: otite (44%, 49%), hipertrofia de amígdala/adenóide (22%, 33%), faringoamigdalite (18%, 23%), rinossunusite (13%, 21%), rinite alérgica (3%, 33%). Análise de concordância kappa foi 0,15 para otite com efusão, 0,35 para otite recorrente, 0,04 para hipertrofia de amígdala/adenóide, 0,43 para faringoamigdalite, 0,05 para rinite alérgica; 0,2 para rinossinusite. Os diagnósticos na atenção primária para encaminhamento à secundária, definidos pelo médico de família ou pelo pediatra que avaliou a criança foram concordantes. CONCLUSÕES: A inadequação dos encaminhamentos da atenção primária para a secundária em otorrinolaringologia foi expressa pelo longo tempo de espera pela consulta e pela baixa concordância de diagnósticos firmados entre os níveis de atenção para os mesmos pacientes avaliados. A atenção primária poderia se tornar mais eficiente se os profissionais fossem mais bem capacitados em otorrinolaringologia. Abstract in english OBJECTIVE: To assess the suitability of referral from primary to secondary care in pediatric Otolaryngology. METHODS: The study was performed in the city of Belo Horizonte, in the state of Minas Gerais, from March 2004 to May 2005. A total of 408 pre-school children referred from primary care to sec [...] ondary care in the department of Otolaryngology presenting with otitis, tonsillitis, sinusitis, allergic rhinitis, and tonsillar/adenoidal hypertrophy was assessed. The studied variables were: agreement between diagnoses in primary and secondary care; waiting time for doctor's appointment; follow-up, and professional (pediatrician or family physician) that examined children in primary care. Agreement of diagnoses was assessed using kappa statistics. RESULTS: Patients were five years old on average, 214 (52.5%) were boys, mean waiting time for appointment was 3.7 months. Diagnoses in primary and secondary care were respectively: otitis (44%, 49%), tonsillar/adenoidal hypertrophy (22%, 33%), tonsillitis (18%, 23%), sinusitis (13%, 21%), allergic rhinitis (3%, 33%). Agreement analysis of kappa was 0.15 for otitis with effusion, 0.35 for recurrent otitis, 0.04 for tonsillar/adenoidal hypertrophy, 0.43 for tonsillitis, 0.05 for allergic rhinitis, and 0.2 for sinusitis. Diagnoses in primary care referred to secondary care were in agreement when given either by pediatrician or family physician. CONCLUSIONS: Unsuitability of referrals from primary to secondary care in otolaryngology was expressed by the long time waiting for appointments and by the low agreement between diagnoses in different level of care for the same patients. Primary health care could be more efficient if professionals were better qualified in Otolaryngology.

  1. Interleukin-12 and Trastuzumab in Treating Patients With Cancer That Has High Levels of HER2/Neu

    Science.gov (United States)

    2013-02-27

    Advanced Adult Primary Liver Cancer; Anaplastic Thyroid Cancer; Bone Metastases; Carcinoma of the Appendix; Distal Urethral Cancer; Fallopian Tube Cancer; Gastrinoma; Glucagonoma; Inflammatory Breast Cancer; Insulinoma; Liver Metastases; Localized Unresectable Adult Primary Liver Cancer; Lung Metastases; Male Breast Cancer; Malignant Pericardial Effusion; Malignant Pleural Effusion; Metastatic Gastrointestinal Carcinoid Tumor; Metastatic Parathyroid Cancer; Metastatic Transitional Cell Cancer of the Renal Pelvis and Ureter; Newly Diagnosed Carcinoma of Unknown Primary; Occult Non-small Cell Lung Cancer; Pancreatic Polypeptide Tumor; Primary Peritoneal Cavity Cancer; Proximal Urethral Cancer; Pulmonary Carcinoid Tumor; Recurrent Adenoid Cystic Carcinoma of the Oral Cavity; Recurrent Adrenocortical Carcinoma; Recurrent Adult Primary Liver Cancer; Recurrent Anal Cancer; Recurrent Bladder Cancer; Recurrent Breast Cancer; Recurrent Carcinoma of Unknown Primary; Recurrent Cervical Cancer; Recurrent Colon Cancer; Recurrent Endometrial Carcinoma; Recurrent Esophageal Cancer; Recurrent Extrahepatic Bile Duct Cancer; Recurrent Gallbladder Cancer; Recurrent Gastric Cancer; Recurrent Gastrointestinal Carcinoid Tumor; Recurrent Islet Cell Carcinoma; Recurrent Malignant Testicular Germ Cell Tumor; Recurrent Mucoepidermoid Carcinoma of the Oral Cavity; Recurrent Non-small Cell Lung Cancer; Recurrent Ovarian Epithelial Cancer; Recurrent Pancreatic Cancer; Recurrent Parathyroid Cancer; Recurrent Prostate Cancer; Recurrent Rectal Cancer; Recurrent Renal Cell Cancer; Recurrent Salivary Gland Cancer; Recurrent Small Intestine Cancer; Recurrent Squamous Cell Carcinoma of the Larynx; Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity; Recurrent Squamous Cell Carcinoma of the Nasopharynx; Recurrent Squamous Cell Carcinoma of the Oropharynx; Recurrent Thyroid Cancer; Recurrent Transitional Cell Cancer of the Renal Pelvis and Ureter; Recurrent Urethral Cancer; Recurrent Vaginal Cancer; Recurrent Vulvar Cancer; Skin Metastases; Small Intestine Adenocarcinoma; Somatostatinoma; Stage III Adenoid Cystic Carcinoma of the Oral Cavity; Stage III Adrenocortical Carcinoma; Stage III Bladder Cancer; Stage III Cervical Cancer; Stage III Colon Cancer; Stage III Endometrial Carcinoma; Stage III Esophageal Cancer; Stage III Follicular Thyroid Cancer; Stage III Gastric Cancer; Stage III Malignant Testicular Germ Cell Tumor; Stage III Mucoepidermoid Carcinoma of the Oral Cavity; Stage III Ovarian Epithelial Cancer; Stage III Pancreatic Cancer; Stage III Papillary Thyroid Cancer; Stage III Prostate Cancer; Stage III Rectal Cancer; Stage III Renal Cell Cancer; Stage III Salivary Gland Cancer; Stage III Squamous Cell Carcinoma of the Larynx; Stage III Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage III Squamous Cell Carcinoma of the Nasopharynx; Stage III Squamous Cell Carcinoma of the Oropharynx; Stage III Vaginal Cancer; Stage III Vulvar Cancer; Stage IIIA Anal Cancer; Stage IIIA Breast Cancer; Stage IIIA Non-small Cell Lung Cancer; Stage IIIB Anal Cancer; Stage IIIB Breast Cancer; Stage IIIB Non-small Cell Lung Cancer; Stage IV Adenoid Cystic Carcinoma of the Oral Cavity; Stage IV Adrenocortical Carcinoma; Stage IV Anal Cancer; Stage IV Bladder Cancer; Stage IV Breast Cancer; Stage IV Colon Cancer; Stage IV Endometrial Carcinoma; Stage IV Esophageal Cancer; Stage IV Follicular Thyroid Cancer; Stage IV Gastric Cancer; Stage IV Mucoepidermoid Carcinoma of the Oral Cavity; Stage IV Non-small Cell Lung Cancer; Stage IV Ovarian Epithelial Cancer; Stage IV Pancreatic Cancer; Stage IV Papillary Thyroid Cancer; Stage IV Prostate Cancer; Stage IV Rectal Cancer; Stage IV Renal Cell Cancer; Stage IV Salivary Gland Cancer; Stage IV Squamous Cell Carcinoma of the Larynx; Stage IV Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage IV Squamous Cell Carcinoma of the Nasopharynx; Stage IV Squamous Cell Carcinoma of the Oropharynx; Stage IVA Cervical Cancer; Stage IVA Vaginal Cancer; Stage IVB Cervical Cancer; Stage IVB Vaginal Cancer; Stage IVB Vulvar

  2. High dose-rate brachytherapy as a treatment option in primary tracheal tumors Braquiterapia de alta taxa de dose como opção terapêutica nos tumores primários da traquéia

    Directory of Open Access Journals (Sweden)

    Heloisa de Andrade Carvalho

    2005-08-01

    Full Text Available PURPOSE: To present experience with high dose-rate endobronchial brachytherapy in the treatment of primary tracheal tumors. PATIENTS AND METHODS: Four patients with nonresected primary tracheal tumors are presented: 2 cases of squamous cell carcinoma of the trachea, 1 of recurrent adenoid cystic carcinoma, and 1 with recurrent plasmacytoma. All received brachytherapy, alone or as a boost for primary irradiation, in 3 or 4 fractions of 7.5 Gy, calculated at a depth of 1 cm. Follow-up was considered to start from the end of brachytherapy. RESULTS: Local control was achieved in all cases at the time of first bronchoscopic evaluation. Two patients with squamous cell carcinoma died at 6th and 33rd months after brachytherapy, respectively. The first had no evidence of disease, and the latter had local recurrence. The other 2 patients were alive after 64 and 110 months of follow-up, respectively, both with no evidence of disease. Tracheal stenosis developed in these 2 cases, 22 and 69 months after brachytherapy. Tracheal stent placement was needed only for the patient with an adenoid cystic carcinoma. CONCLUSIONS: Endobronchial high dose-rate brachytherapy may be used for tracheal tumors, even as a boost for external beam irradiation, or in recurrences. Local control in 3 out of 4 patients indicates that individual cases may benefit from the treatment. Long-term survival may also be expected, mainly for tumors with adenoid cystic histology.OBJETIVO: Apresentar a experiência do tratamento de 4 pacientes com tumores primários de traquéia, não operados, submetidos à braquiterapia endobrônquica de alta taxa de dose. PACIENTES E MÉTODOS: Dois casos de carcinoma espinocelular, uma recidiva de carcinoma adenóide cístico e uma recidiva de plasmocitoma primário da traquéia. Todos receberam braquiterapia endobrônquica, exclusiva ou como reforço de dose da radioterapia externa. Foram administradas 3 ou 4 frações de 7,5 Gy cada, calculados a 1 cm de profundidade. O seguimento foi considerado a partir do término da braquiterapia. RESULTADOS: Em todos os casos houve resposta completa. Dois pacientes com carcinoma espinocelular evoluíram a óbito em 6 e 33 meses após a braquiterapia, o primeiro, sem evidência de doença e o outro por recidiva local, respectivamente. As outras 2 pacientes encontravam-se vivas após 64 e 110 meses de seguimento, sem evidência de doença. Esses 2 casos apresentaram estenose traqueal em 22 e 69 meses após a braquiterapia, sendo necessária a colocação de prótese traqueal apenas na paciente com carcinoma adenóide cístico. CONCLUSÕES: A braquiterapia endobrônquica de alta taxa de dose pode ser utilizada tanto como reforço de dose da irradiação externa quanto em recidivas. O controle local obtido em 3 de 4 pacientes indica que casos individuais podem se beneficiar desse procedimento. Sobrevida a longo prazo pode ser observada, principalmente nos casos de histologia adenóide cística.

  3. Metástasis óseas, primera manifestación clínica de un carcinoma productor de calcitonina

    Scientific Electronic Library Online (English)

    M., Urdiales Viedma; R., Carvia Ponsaille; J., Barranco García; S., Martos Padilla; R., López Urdiales.

    2005-04-01

    Full Text Available SciELO Spain | Language: Spanish Abstract in spanish INTRODUCCIÓN: el carcinoma medular de tiroides comprende entre el 5%-10% de todos los carcinomas tiroideos. La presentación clínica más frecuente es una masa tiroidea. CASO CLÍNICO: varón de 32 años, con dolores debidos a múltiples metástasis óseas. Una biopsia de médula ósea mostró un carcinoma con [...] positividad inmunohistoquímica a calcitonina y antígeno carcinoembrionario. Los niveles séricos de calcitonina y antígeno carcinoembrionario estaban muy altos. El paciente murió a los 12 meses del diagnóstico a pesar de ser sometido a quimio y radioterapia. DISCUSIÓN: las metástasis a distancia son una manifestación inicial infrecuente en el carcinoma medular de tiroides. Pacientes con menos de 45 años tienen mejor supervivencia, pero la existencia de metástasis óseas se correlaciona con mal pronóstico. Las determinaciones inmunohistoquímicas y séricas de calcitonina y antígeno carcinoembrionario son importantes instrumentos diagnósticos. CONCLUSIÓN: mostramos lo que creemos es un carcinoma medular de tiroides en un varón joven, con una presentación inicial atípica debido a múltiples metástasis óseas y curso fatal. La inmunohistoquimia es fundamental para diagnosticar el tumor primario en estas metástasis. En el caso de calcitonina y/o antígeno carcinoembrionario plasmático elevado y no explicado, es imprescindible descartar un carcinoma medular de tiroides. Abstract in english PURPOSE: Thyroid medullary carcinoma comprises between 5 and 10 % of all thyroid cancers. The most common clinical presentation is a thyroid mass. Study of a case with bone metastases. CASE REPORT: A 32 year old man with pain due to multiple bone metastases. A bone marrow biopsy disclosed a carcinom [...] a immunologically positive to calcitonin and carcinoembryonic antigen. Serum level of both, calcitonin and carcinoembryonic antigen, were very high. The patient was treated with chemotherapy and radiotherapy, and died 12 months later. DISCUSSION: Distant metastases are not a usual presentation of thyroid medullary carcinoma. Patients younger than 45 years have a better survival, but bone metastases correlate with a very bad prognosis. Immunohistochemistry and blood determination of carcinoembryonic antigen and calcitonin are important diagnostic tools. CONCLUSION: Atypical presentation of a thyroid medullary carcinoma in a young man with bone metastases and short survival. Immunohistochemistry is very useful to establish the origin of the primary tumour in these metastases. In the event of an unexplained plasma rise of calcitonin and/or carcinoembryonic antigen, it is mandatory to rule out a thyroid medullary carcinoma.

  4. Long-term Outcomes and Quality of Life of 186 Patients With Primary Parotid Carcinoma Treated With Surgery and Radiotherapy at the Daniel den Hoed Cancer Center

    International Nuclear Information System (INIS)

    Purpose: To assess the outcomes, toxicity, and quality of life (QOL) of patients with primary parotid carcinoma treated with surgery and postoperative radiotherapy at the Daniel den Hoed Cancer Center. Methods and Materials: Between 1995 and 2010, 186 patients with parotid carcinoma were treated with parotidectomy with or without neck dissection, followed by radiotherapy. Elective nodal irradiation (ENI) was applied to high-risk, node-negative disease. End points were locoregional control (LRC), disease-free survival (DFS), cause-specific survival (CSS), and overall survival (OS), late toxicity, and QOL. Results: After a median follow-up of 58 months (range, 4–172 months), the 5-year Kaplan-Meier estimates for LRC, DFS, CSS, and OS were 89%, 83%, 80%, and 68%, respectively. Forty-five events were reported: 24 distant metastases (DM) and 21 locoregional failures (LRF). Event-free survival rates by histological types were 89%, 78%, 76%, 74%, and 70% for acinic cell, mucoepidermoid, adenoid cystic, adenocarcinoma, and squamous cell carcinoma, respectively. More LRF were reported in patients with squamous cell and high-grade mucoepidermoid carcinoma (21% and 19%, respectively) than in patients with other histological types (p = 0.04) and more DM in patients with adenoid cystic and adenocarcinoma (20% and 19%, respectively) than in patients with other types (p = 0.03). None of the high-risk node-negative patients who received ENI developed regional failure. On multivariaeveloped regional failure. On multivariate analysis, T stage, N stage, grade, and presence of perineural invasion and facial paralysis correlated significantly with DFS. The 5-year cumulative incidence of grade ?2 late toxicity was 8%. QOL scores deteriorate during and shortly after treatment but returned in almost all scales to baseline scores within 6 months. Conclusions: Of the entire group, surgery and postoperative radiotherapy resulted in excellent outcomes with minimal side effects and preservation of good QOL scores. However, in view of the pattern of failures observed in this study, the role of adjuvant systemic or targeted therapy in patients at high risk of DM should be investigated in prospective trials.

  5. Long-term Outcomes and Quality of Life of 186 Patients With Primary Parotid Carcinoma Treated With Surgery and Radiotherapy at the Daniel den Hoed Cancer Center

    Energy Technology Data Exchange (ETDEWEB)

    Al-Mamgani, Abrahim, E-mail: a.al-mamgani@erasmusmc.nl [Department of Radiation Oncology, Erasmus Medical Center-Daniel den Hoed Cancer Center, Rotterdam (Netherlands); Rooij, Peter van [Department of Biostatistics, Erasmus Medical Center-Daniel den Hoed Cancer Center, Rotterdam (Netherlands); Verduijn, Gerda M. [Department of Radiation Oncology, Erasmus Medical Center-Daniel den Hoed Cancer Center, Rotterdam (Netherlands); Meeuwis, Cees A. [Department of Otorhinolaryngology, Erasmus Medical Center-Daniel den Hoed Cancer Center, Rotterdam (Netherlands); Levendag, Peter C. [Department of Radiation Oncology, Erasmus Medical Center-Daniel den Hoed Cancer Center, Rotterdam (Netherlands)

    2012-09-01

    Purpose: To assess the outcomes, toxicity, and quality of life (QOL) of patients with primary parotid carcinoma treated with surgery and postoperative radiotherapy at the Daniel den Hoed Cancer Center. Methods and Materials: Between 1995 and 2010, 186 patients with parotid carcinoma were treated with parotidectomy with or without neck dissection, followed by radiotherapy. Elective nodal irradiation (ENI) was applied to high-risk, node-negative disease. End points were locoregional control (LRC), disease-free survival (DFS), cause-specific survival (CSS), and overall survival (OS), late toxicity, and QOL. Results: After a median follow-up of 58 months (range, 4-172 months), the 5-year Kaplan-Meier estimates for LRC, DFS, CSS, and OS were 89%, 83%, 80%, and 68%, respectively. Forty-five events were reported: 24 distant metastases (DM) and 21 locoregional failures (LRF). Event-free survival rates by histological types were 89%, 78%, 76%, 74%, and 70% for acinic cell, mucoepidermoid, adenoid cystic, adenocarcinoma, and squamous cell carcinoma, respectively. More LRF were reported in patients with squamous cell and high-grade mucoepidermoid carcinoma (21% and 19%, respectively) than in patients with other histological types (p = 0.04) and more DM in patients with adenoid cystic and adenocarcinoma (20% and 19%, respectively) than in patients with other types (p = 0.03). None of the high-risk node-negative patients who received ENI developed regional failure. On multivariate analysis, T stage, N stage, grade, and presence of perineural invasion and facial paralysis correlated significantly with DFS. The 5-year cumulative incidence of grade {>=}2 late toxicity was 8%. QOL scores deteriorate during and shortly after treatment but returned in almost all scales to baseline scores within 6 months. Conclusions: Of the entire group, surgery and postoperative radiotherapy resulted in excellent outcomes with minimal side effects and preservation of good QOL scores. However, in view of the pattern of failures observed in this study, the role of adjuvant systemic or targeted therapy in patients at high risk of DM should be investigated in prospective trials.

  6. Lesiones intraorales de glándulas salivales menores / Intraoral lesions of minor salivary glands. Analysis of 59 patients

    Scientific Electronic Library Online (English)

    MARÍA ANGÉLICA, MATAMALA S; MIGUEL, GONZÁLEZ P; GONZALO, ROSSEL D; CONSTANZA, NIEME S.

    2012-08-01

    Full Text Available Introducción: Las lesiones de glándulas salivales menores son en su mayoría benignas. Los tumores son infrecuentes y conforman un grupo heterogéneo, siendo el adenoma pleomorfo Ia neoplasia benigna más frecuente y el carcinoma adenoideo-quistico el tumor maligno más encontrado. Objetivos: El propósi [...] to de este estudio es evaluar Ia incidencia, manejo y evolución de Ias lesiones intraorales de glándulas salivales menores en el Servicio de Cirugia de Cabeza y Cuello del Hospital Barros Luco-Trudeau. Material y Método: Se presenta estudio retrospectivo de 59 casos tratados entre 1975 y 2009 en dicho hospital. Resultados: Encontramos 35 mujeres y 24 hombres. En 48 pacientes (81,3%) se encontró lesiones benignas, de Ias cuales 35 (73%) correspondieron a lesiones no neoplásicas y 13 (27%) a neoplasias. Las neoplasias malignas fueron 11 (18,6% del total), 4 (36,3%) con Ca mucoepidermoide, 2 (18%) con Ca adenoideo-quistico, 2 (18%) con Ca de células acinosas, 1 (9%) con Ca indiferenciado, 1 (9%) con adenocarcinoma y 1 (9%) con Ca epider-moide. Conclusiones: Las lesiones de glándulas salivales menores en nuestro hospital se caracterizan por ser predominantemente benignas. Se encontró similar frecuencia de tumores benignos y malignos. Predominó el adenoma pleomorfo entre Ios primeros y el carcinoma mucoepidermoide entre Ios segundos. Los tumores benignos, luego de su extirpación, se manejaron con cierre del lecho tumoral mediante rotación de colgajos locales de mucosa oral para cobertura y, en algunos casos, cierre por segunda intención. La evolución fue en general excelente. En el caso de Ios tumores malignos, el manejo dependió de Ia histología. Abstract in english Background: Most salivary gland lesions are benign. Tumors are uncommon. Pleomorphic adenoma and cystic adenoid carcinoma are the most common benign and malignant lesions. Alm: To assess the incidence management and evolution of intraoral lesions among patients consulting in a head and neck surgical [...] service. Material and Methods: Retrospective review of medical records of patients consulting for intraoral lesions of minor salivary glands between 1975 and 2009 in a head and neck surgical service. Results: Thirty five females and 24 males are reported. Forty eight (81%) had benign lesions. Of these, 35 (73%). were non neoplastic lesions. Eleven patients had malignant lesions. Of these, four (36%) had a mucoepidermoid carcinoma, two (18%) had an adenoid-cystic carcinoma, two (18%) had an acinous cell carcinoma and one patient each had an undifferentiated carcinoma, an adenocarcinoma and an epidermoid carcinoma. Conclusions: In this series of patients, benign lesions predominated. Benign lesions were excised and the management of malignant lesions depended on the type of tumor.

  7. Lesiones intraorales de glándulas salivales menores Intraoral lesions of minor salivary glands. Analysis of 59 patients

    Directory of Open Access Journals (Sweden)

    MARÍA ANGÉLICA MATAMALA S

    2012-08-01

    Full Text Available Introducción: Las lesiones de glándulas salivales menores son en su mayoría benignas. Los tumores son infrecuentes y conforman un grupo heterogéneo, siendo el adenoma pleomorfo Ia neoplasia benigna más frecuente y el carcinoma adenoideo-quistico el tumor maligno más encontrado. Objetivos: El propósito de este estudio es evaluar Ia incidencia, manejo y evolución de Ias lesiones intraorales de glándulas salivales menores en el Servicio de Cirugia de Cabeza y Cuello del Hospital Barros Luco-Trudeau. Material y Método: Se presenta estudio retrospectivo de 59 casos tratados entre 1975 y 2009 en dicho hospital. Resultados: Encontramos 35 mujeres y 24 hombres. En 48 pacientes (81,3% se encontró lesiones benignas, de Ias cuales 35 (73% correspondieron a lesiones no neoplásicas y 13 (27% a neoplasias. Las neoplasias malignas fueron 11 (18,6% del total, 4 (36,3% con Ca mucoepidermoide, 2 (18% con Ca adenoideo-quistico, 2 (18% con Ca de células acinosas, 1 (9% con Ca indiferenciado, 1 (9% con adenocarcinoma y 1 (9% con Ca epider-moide. Conclusiones: Las lesiones de glándulas salivales menores en nuestro hospital se caracterizan por ser predominantemente benignas. Se encontró similar frecuencia de tumores benignos y malignos. Predominó el adenoma pleomorfo entre Ios primeros y el carcinoma mucoepidermoide entre Ios segundos. Los tumores benignos, luego de su extirpación, se manejaron con cierre del lecho tumoral mediante rotación de colgajos locales de mucosa oral para cobertura y, en algunos casos, cierre por segunda intención. La evolución fue en general excelente. En el caso de Ios tumores malignos, el manejo dependió de Ia histología.Background: Most salivary gland lesions are benign. Tumors are uncommon. Pleomorphic adenoma and cystic adenoid carcinoma are the most common benign and malignant lesions. Alm: To assess the incidence management and evolution of intraoral lesions among patients consulting in a head and neck surgical service. Material and Methods: Retrospective review of medical records of patients consulting for intraoral lesions of minor salivary glands between 1975 and 2009 in a head and neck surgical service. Results: Thirty five females and 24 males are reported. Forty eight (81% had benign lesions. Of these, 35 (73%. were non neoplastic lesions. Eleven patients had malignant lesions. Of these, four (36% had a mucoepidermoid carcinoma, two (18% had an adenoid-cystic carcinoma, two (18% had an acinous cell carcinoma and one patient each had an undifferentiated carcinoma, an adenocarcinoma and an epidermoid carcinoma. Conclusions: In this series of patients, benign lesions predominated. Benign lesions were excised and the management of malignant lesions depended on the type of tumor.

  8. Cetuximab and Everolimus in Treating Patients With Metastatic or Recurrent Colon Cancer or Head and Neck Cancer

    Science.gov (United States)

    2012-07-06

    Recurrent Adenoid Cystic Carcinoma of the Oral Cavity; Recurrent Basal Cell Carcinoma of the Lip; Recurrent Colon Cancer; Recurrent Esthesioneuroblastoma of the Paranasal Sinus and Nasal Cavity; Recurrent Inverted Papilloma of the Paranasal Sinus and Nasal Cavity; Recurrent Lymphoepithelioma of the Nasopharynx; Recurrent Lymphoepithelioma of the Oropharynx; Recurrent Metastatic Squamous Neck Cancer With Occult Primary; Recurrent Midline Lethal Granuloma of the Paranasal Sinus and Nasal Cavity; Recurrent Mucoepidermoid Carcinoma of the Oral Cavity; Recurrent Salivary Gland Cancer; Recurrent Squamous Cell Carcinoma of the Hypopharynx; Recurrent Squamous Cell Carcinoma of the Larynx; Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity; Recurrent Squamous Cell Carcinoma of the Nasopharynx; Recurrent Squamous Cell Carcinoma of the Oropharynx; Recurrent Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity; Recurrent Verrucous Carcinoma of the Larynx; Recurrent Verrucous Carcinoma of the Oral Cavity; Stage IV Adenoid Cystic Carcinoma of the Oral Cavity; Stage IV Basal Cell Carcinoma of the Lip; Stage IV Lymphoepithelioma of the Nasopharynx; Stage IV Lymphoepithelioma of the Oropharynx; Stage IV Mucoepidermoid Carcinoma of the Oral Cavity; Stage IV Squamous Cell Carcinoma of the Hypopharynx; Stage IV Squamous Cell Carcinoma of the Larynx; Stage IV Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage IV Squamous Cell Carcinoma of the Nasopharynx; Stage IV Squamous Cell Carcinoma of the Oropharynx; Stage IV Verrucous Carcinoma of the Larynx; Stage IV Verrucous Carcinoma of the Oral Cavity; Stage IVA Colon Cancer; Stage IVA Esthesioneuroblastoma of the Paranasal Sinus and Nasal Cavity; Stage IVA Inverted Papilloma of the Paranasal Sinus and Nasal Cavity; Stage IVA Midline Lethal Granuloma of the Paranasal Sinus and Nasal Cavity; Stage IVA Salivary Gland Cancer; Stage IVA Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity; Stage IVB Colon Cancer; Stage IVB Esthesioneuroblastoma of the Paranasal Sinus and Nasal Cavity; Stage IVB Inverted Papilloma of the Paranasal Sinus and Nasal Cavity; Stage IVB Midline Lethal Granuloma of the Paranasal Sinus and Nasal Cavity; Stage IVB Salivary Gland Cancer; Stage IVB Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity; Stage IVC Esthesioneuroblastoma of the Paranasal Sinus and Nasal Cavity; Stage IVC Inverted Papilloma of the Paranasal Sinus and Nasal Cavity; Stage IVC Midline Lethal Granuloma of the Paranasal Sinus and Nasal Cavity; Stage IVC Salivary Gland Cancer; Stage IVC Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity; Tongue Cancer

  9. Erlotinib Hydrochloride and Cetuximab in Treating Patients With Advanced Gastrointestinal Cancer, Head and Neck Cancer, Non-Small Cell Lung Cancer, or Colorectal Cancer

    Science.gov (United States)

    2014-09-24

    Adenocarcinoma of the Colon; Adenocarcinoma of the Rectum; Advanced Adult Primary Liver Cancer; Carcinoma of the Appendix; Gastrointestinal Stromal Tumor; Metastatic Gastrointestinal Carcinoid Tumor; Metastatic Squamous Neck Cancer With Occult Primary; Recurrent Adenoid Cystic Carcinoma of the Oral Cavity; Recurrent Adult Primary Liver Cancer; Recurrent Anal Cancer; Recurrent Basal Cell Carcinoma of the Lip; Recurrent Colon Cancer; Recurrent Esophageal Cancer; Recurrent Esthesioneuroblastoma of the Paranasal Sinus and Nasal Cavity; Recurrent Extrahepatic Bile Duct Cancer; Recurrent Gallbladder Cancer; Recurrent Gastric Cancer; Recurrent Gastrointestinal Carcinoid Tumor; Recurrent Inverted Papilloma of the Paranasal Sinus and Nasal Cavity; Recurrent Lymphoepithelioma of the Nasopharynx; Recurrent Lymphoepithelioma of the Oropharynx; Recurrent Metastatic Squamous Neck Cancer With Occult Primary; Recurrent Midline Lethal Granuloma of the Paranasal Sinus and Nasal Cavity; Recurrent Mucoepidermoid Carcinoma of the Oral Cavity; Recurrent Non-small Cell Lung Cancer; Recurrent Pancreatic Cancer; Recurrent Rectal Cancer; Recurrent Salivary Gland Cancer; Recurrent Small Intestine Cancer; Recurrent Squamous Cell Carcinoma of the Hypopharynx; Recurrent Squamous Cell Carcinoma of the Larynx; Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity; Recurrent Squamous Cell Carcinoma of the Nasopharynx; Recurrent Squamous Cell Carcinoma of the Oropharynx; Recurrent Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity; Recurrent Verrucous Carcinoma of the Larynx; Recurrent Verrucous Carcinoma of the Oral Cavity; Small Intestine Adenocarcinoma; Small Intestine Leiomyosarcoma; Small Intestine Lymphoma; Stage IV Adenoid Cystic Carcinoma of the Oral Cavity; Stage IV Anal Cancer; Stage IV Basal Cell Carcinoma of the Lip; Stage IV Colon Cancer; Stage IV Esophageal Cancer; Stage IV Esthesioneuroblastoma of the Paranasal Sinus and Nasal Cavity; Stage IV Gastric Cancer; Stage IV Inverted Papilloma of the Paranasal Sinus and Nasal Cavity; Stage IV Lymphoepithelioma of the Nasopharynx; Stage IV Lymphoepithelioma of the Oropharynx; Stage IV Midline Lethal Granuloma of the Paranasal Sinus and Nasal Cavity; Stage IV Mucoepidermoid Carcinoma of the Oral Cavity; Stage IV Non-small Cell Lung Cancer; Stage IV Pancreatic Cancer; Stage IV Rectal Cancer; Stage IV Salivary Gland Cancer; Stage IV Squamous Cell Carcinoma of the Hypopharynx; Stage IV Squamous Cell Carcinoma of the Larynx; Stage IV Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage IV Squamous Cell Carcinoma of the Nasopharynx; Stage IV Squamous Cell Carcinoma of the Oropharynx; Stage IV Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity; Stage IV Verrucous Carcinoma of the Larynx; Stage IV Verrucous Carcinoma of the Oral Cavity; Tongue Cancer; Unresectable Extrahepatic Bile Duct Cancer; Unresectable Gallbladder Cancer

  10. Availability and quality of paraffin blocks identified in pathology archives: A multi-institutional study by the Shared Pathology Informatics Network (SPIN

    Directory of Open Access Journals (Sweden)

    Schirripa Osvaldo

    2007-02-01

    Full Text Available Abstract Background Shared Pathology Informatics Network (SPIN is a tissue resource initiative that utilizes clinical reports of the vast amount of paraffin-embedded tissues routinely stored by medical centers. SPIN has an informatics component (sending tissue-related queries to multiple institutions via the internet and a service component (providing histopathologically annotated tissue specimens for medical research. This paper examines if tissue blocks, identified by localized computer searches at participating institutions, can be retrieved in adequate quantity and quality to support medical researchers. Methods Four centers evaluated pathology reports (1990–2005 for common and rare tumors to determine the percentage of cases where suitable tissue blocks with tumor were available. Each site generated a list of 100 common tumor cases (25 cases each of breast adenocarcinoma, colonic adenocarcinoma, lung squamous carcinoma, and prostate adenocarcinoma and 100 rare tumor cases (25 cases each of adrenal cortical carcinoma, gastro-intestinal stromal tumor [GIST], adenoid cystic carcinoma, and mycosis fungoides using a combination of Tumor Registry, laboratory information system (LIS and/or SPIN-related tools. Pathologists identified the slides/blocks with tumor and noted first 3 slides with largest tumor and availability of the corresponding block. Results Common tumors cases (n = 400, the institutional retrieval rates (all blocks were 83% (A, 95% (B, 80% (C, and 98% (D. Retrieval rate (tumor blocks from all centers for common tumors was 73% with mean largest tumor size of 1.49 cm; retrieval (tumor blocks was highest-lung (84% and lowest-prostate (54%. Rare tumors cases (n = 400, each institution's retrieval rates (all blocks were 78% (A, 73% (B, 67% (C, and 84% (D. Retrieval rate (tumor blocks from all centers for rare tumors was 66% with mean largest tumor size of 1.56 cm; retrieval (tumor blocks was highest for GIST (72% and lowest for adenoid cystic carcinoma (58%. Conclusion Assessment shows availability and quality of archival tissue blocks that are retrievable and associated electronic data that can be of value for researchers. This study serves to compliment the data from which uniform use of the SPIN query tools by all four centers will be measured to assure and highlight the usefulness of archival material for obtaining tumor tissues for research.

  11. Expression of metallothionein I/II and Ki-67 antigen in various histological types of basal cell carcinoma Expression of metallothionein I/II and Ki-67 antigen in various histological types of basal cell carcinoma

    Directory of Open Access Journals (Sweden)

    Andrzej Bieniek

    2012-10-01

    Full Text Available Basal cell carcinoma (BCC is the most frequent skin cancer, with many different histological subtypes.
    Recent studies have investigated the expression of proliferative markers, but little is known about the
    expression of metallothioneins (MT in different histological subtypes of this cancer and their impact on proliferation
    intensity in BCC. In this study, we examined MT-I/II expression by immunohistochemistry in 58 different
    histological subtypes of BCC (38 nodular, six adenoid, eight infiltrative, and six metatypic cases and correlated
    its expression with tumor size and Ki-67 proliferation rate. Statistical analysis revealed no significant differences
    in the expression of studied markers in regard to the histological subtype. A positive correlation between
    MT and Ki-67 expression was observed for all the studied cases (r = 0.26; p = 0.049, but was even
    stronger in the metatypic subtype of BCC (r = 0.85; p = 0.033. MT and Ki-67 expression did not correlate with
    tumor size. In conclusion, it seems that metallothioneins may have an impact on the proliferation rate of BCC,
    but further studies are required to determine whether MT may be a risk factor of recurrences.
    Basal cell carcinoma (BCC is the most frequent skin cancer, with many different histological subtypes.
    Recent studies have investigated the expression of proliferative markers, but little is known about the
    expression of metallothioneins (MT in different histological subtypes of this cancer and their impact on proliferation
    intensity in BCC. In this study, we examined MT-I/II expression by immunohistochemistry in 58 different
    histological subtypes of BCC (38 nodular, six adenoid, eight infiltrative, and six metatypic cases and correlated
    its expression with tumor size and Ki-67 proliferation rate. Statistical analysis revealed no significant differences
    in the expression of studied markers in regard to the histological subtype. A positive correlation between
    MT and Ki-67 expression was observed for all the studied cases (r = 0.26; p = 0.049, but was even
    stronger in the metatypic subtype of BCC (r = 0.85; p = 0.033. MT and Ki-67 expression did not correlate with
    tumor size. In conclusion, it seems that metallothioneins may have an impact on the proliferation rate of BCC,
    but further studies are required to determine whether MT may be a risk factor of recurrences.

  12. Disfonia crónica numa criança / Hoarseness in a child due to laryngopharyngeal reflux

    Scientific Electronic Library Online (English)

    Ana, Dantas; Ana, Magalhães; Maria João, Oliveira; Olena, Lourenço; Paulo Baptista, Coelho.

    2011-11-01

    Full Text Available Introdução: Os sintomas associados ao refluxo gastroesofágico (RGE) nas crianças variam com a idade, atingindo uma prevalência de 1,8% a 8,2%. Os principais sintomas em crianças mais velhas e adolescentes são azia e regurgitação. Uma complicação possível é a disfonia crónica devido à laringite por r [...] efluxo (refluxo laringo-faríngeo - RLF). O objectivo deste caso é alertar para o RLF/RGE como uma causa de disfonia crónica em idade pediátrica. Descrição do caso: Relata-se o caso de uma menina de seis anos que recorreu ao seu médico de família (MF) para uma consulta de rotina. O MF detectou disfonia cuja cronicidade foi confirmada pela mãe. A menina foi referenciada à Otorrinolaringologia (ORL), onde efectuou uma nasofaringolaringoscopia. Detectaram hipertrofia das adenoides, edema da corda vocal direita e sulcus glottidis, tendo diagnosticado RLF. Prescreveram esomeprazol e terapia da voz, tendo a disfonia remitido após nove meses. Comentário: O RLF condicionou lesão das cordas vocais, originando disfonia. O tratamento adequado resolveu os sintomas. A disfonia é pouco reconhecida pelos doentes, pelos seus pais e mesmo pelos médicos. No entanto, pode ser o único sintoma de RLF/RGE. Não detectar a disfonia atrasa o diagnóstico e o tratamento, aumentando as complicações e piorando o prognóstico. Abstract in english Introduction: Symptoms associated with gastroesophageal reflux (GER) in children vary according to age. The prevalence ranges from 1,8% to 8,2%. The cardinal symptoms among older children and adolescents are heartburn and regurgitation. One possible complication is chronic hoarseness due to reflux l [...] aryngitis (laryngopharyngeal reflux - LPR). The goal of this case report is to alert physicians to the possibility of LPR/GER as a cause of chronic hoarseness in children. Case Report: We report the case of a six year old girl who consulted her general practitioner (GP) for a routine visit. The GP noticed hoarseness that her mother confirmed to be chronic. The girl was referred to an otorhinolaryngologist (ORL) who performed a nasopharyngolaryngoscopy. He found adenoid hypertrophy, right vocal fold edema and sulcus glottidis, and diagnosed LPR. The ORL prescribed esomeprazole and speech therapy. Nine months later the hoarseness was resolved. Comment: LPR caused trauma to the vocal folds resulting in hoarseness. Appropriate treatment resolved the symptoms. Hoarseness is insufficiently recognized by young patients, their parents and even by physicians. It may be the only symptom of LPR/GER. Failure to recognize it may delay diagnosis and treatment, increase complications and worsen prognosis.

  13. Clinical and biochemical experience of mucopolysaccharidosis in Cartagena de Indias. Colombia

    Directory of Open Access Journals (Sweden)

    Alvear-Sedan Ciro César

    2013-06-01

    Full Text Available Introduction: mucopolysaccharidoses known as MPS are a group of hereditary metabolic diseases, caused by the absence or bad functioning of certain lysosomal enzymes necessary for the processing of molecules called glycosaminoglycans (GAGs ormucopolysaccharidos. When the deterioration process of GAGs is altered, a progressiveintralysosomal store of the insufficiently catabolized substrates is produced, whichentails to the clinical manifestations of MPS.Clinical cases: Five cases of MPS are presented. They correspond to five patientswho are natural, resident and proceeding from Cartagena, between 4.5 and 12 yearsof age. Two of them were women and three of them were men. There were not norconsanguinity between their parents, neither important family histories. Two patientshad retard in their psychomotor development. Two had history of respiratory problemssuch as adenoiditis and pneumonia. In the physical exam, all of them had coarse facies.Two had dolichocephaly, one had turricephaly and other had cranial asymmetry. Onlyone patient showed corneal opacity, all patients had short neck and broad hands. Onepatient presented hepatomegaly, two presented scoliosis and one presented kyphosis.Conclusions: Early diagnosis of MPS continues being a challenge for the clinical doctor. The early recognition of symptoms is necessary. Some enzymatic replacement therapiesalready exist to prevent or to mitigate the morbimortality. Rev.cienc.biomed. 2013;4(1:152-158RESUMEN:Introducción: las mucopolisacaridosis, conocidas como MPS, son un grupo deenfermedades metabólicas hereditarias, causadas por la ausencia o el mal funcionamientode ciertas enzimas lisosomales necesarias para el procesamiento de moléculas llamadasglicosaminoglicanos (GAGs o mucopolisacáridos. Cuando el proceso de degradaciónde los GAGs se encuentra alterado, se produce un depósito intralisosomal progresivode los sustratos insuficientemente catabolizados, lo que conlleva a las manifestacionesclínicas de las MPS.Casos clínicos: se presentan cinco casos de MPS. Corresponden a cinco pacientesnaturales, residentes y procedentes de la ciudad de Cartagena, entre los 4.5 y 12años de edad. Dos de ellos de sexo femenino y tres de sexo masculino. No existíaconsanguinidad entre sus progenitores, ni antecedentes familiares de importancia. Dospacientes cursaron con retraso en su desarrollo psicomotor. Dos tuvieron antecedentesde problemas respiratorios tipo adenoiditis y neumonía. En el exámen físico se encontrófascies burdas en todos ellos. Dos con dolicocefalia, uno con turrincefalia y otro conasimetría craneal. Solo en un paciente se evidenció opacidad corneal, todos tuvieroncuello corto y manos anchas. Un paciente tuvo hepatomegalia, dos con escoliosis y unocifosis.Conclusiones: el diagnóstico precoz de las MPS sigue siendo un reto para el médicoclínico. El reconocimiento temprano de los síntomas es necesario. Ya se dispone dealgunas terapias de reemplazo enzimático, para prevenir o mitigar la morbimortalidad.Rev.cienc.biomed. 2013;4(1:152-158

  14. Buccal space lesions: a new classification based on CT and MR imaging findings

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Hyo Cheol; Han, Moon Hee; Moon, Min Hoan [College of Medicine, Seoul National Univ., Seoul (Korea, Republic of)] [and others

    2004-02-01

    To present a new classification based on the CT and MR imaging findings of buccal space lesions, and to propose guidelines for their radiologic differentiation. Sixty-two histopathologically confirmed or clinically diagnosed buccal space lesions were classified on the basis of their morphologic appearance and extension to adjacent space as either (1) a mass with a distinct margin, confined to the buccal space; (2) a mass with surrounding infiltration, confined to the buccal space; or (3) a multi-space occupying mass. Type 1 included pleomorphic adenoma, ex-pleomorphic adenoma, carcinoma, B-cell lymphoma, acinic cell carcinoma, rhabdomyosarcoma, glomus tumor and ameloblastoma, and differentiation between malignant and benign neoplasms was not possible. Type 2 included adenoid cystic carcinoma, abscess, complicated dermoid cyst, and Kimura disease. T-cell lymphoma, neurofibroma, vascular malformation, inflammation, and foreign body granuloma pertained to type 3, and each type-3 entity showed different imaging characteristics. This new classification based on CT and MR imaging characteristics may provide useful guide-lines for predicting the differential diagnosis of buccal space lesions.

  15. [Strategy of combined treatment in patient with cancer of paranasal sinuses].

    Science.gov (United States)

    Kiprian, Dorota

    2007-01-01

    Cancers of pranasal sinuses are rare neoplasms in humans. In 2003, in Poland there were 132 new patients diagnosed for this disease. Squamous cell cancer is the most frequent one in this region. Other types of cancer in this region are adenocarcinoma (about 30%), carcinoma adenoides cysticum or neoplasms such as rhabdosarcoma, chondrosarcoma, lymphoma or melanoma malignum. There is a very rare neoplasm as a olfactory neuroblastoma in this localization. Cancer of the paranasal sinuses infiltrates only locoregionally. Metastases to the lymph nodes are seldom--below 30%; this is why elective lymphangiectomy or irradiation are not obligatory treatment in this case. The most important is histopathological verification performed by biopsy. For clinical staging it is obligatory to perform endoscopy, CT or MR examination. The treatment of cancers of paranasal sinuses is always surgery with adjuvant irradiation. The modern radiotherapy techniques provide the possibility to spare healthy tissues and organs at risk. The organs at risk in this localization are optical nerves and chiasm, and parotid glands. The conformal radiotherapy is used most frequently. In case of the tumour being of complex shape and located in the vicinity of the organs at risk the IMRT technique is used. The radiation treatment combined with chemotherapy is applied in cases of not radical surgery in the region of ethmoides sinuses. PMID:18260245

  16. CT findings of nasomaxillary lesions: differential diagnosis by adjacent bony abnormality on CT

    International Nuclear Information System (INIS)

    To provide an aid in differential diagnosis of nasomaxillary lesions by CT appearance of bony changes, we retrospectively evaluated 82 computed tomographic (CT) examinations of 79 patients who had nasomaxillary lesions (56 tumors, 23 inflammations). The bony changes were classified as destruction, displacement, and sclerosis. Destruction of bony maxilla was most common in malignancy, in which more than 3 walls were often destroyed. Displacement of bony maxilla was most common in benign tumors and in slowly - growing malignant tumors such as adenoid cystic carcinoma or lymphoma, and there was often associated bony destruction of other walls. Sclerosis was a common finding in the inflammatory process, especially in chronic maxillary sinusitis with bony destruction at the ostium of the medial wall, Sclerosis often occurred after radiotherapy and / or chemotherapy of tumors and was also noted when there was associated inflammation. Maxillary cysts showed characteristic expansion of all sinus walls. Bony changes were less prominent in the tumors of the nasal cavity compared to the changes seen in the maxillary lesions. A careful analysis of CT findings is very helpful in differentiating malignant from benign tumors and inflammatory disease in nasomaxillary lesions

  17. CT findings of nasomaxillary lesions: differential diagnosis by adjacent bony abnormality on CT

    Energy Technology Data Exchange (ETDEWEB)

    Park, Yeon Won; Jung, Dong Kwang; Huh, Jin Do; Kim, Ho Joon; Chun, Byung Hee; Joh, Young D. [Kosin Medical College, Busan (Korea, Republic of)

    1991-07-15

    To provide an aid in differential diagnosis of nasomaxillary lesions by CT appearance of bony changes, we retrospectively evaluated 82 computed tomographic (CT) examinations of 79 patients who had nasomaxillary lesions (56 tumors, 23 inflammations). The bony changes were classified as destruction, displacement, and sclerosis. Destruction of bony maxilla was most common in malignancy, in which more than 3 walls were often destroyed. Displacement of bony maxilla was most common in benign tumors and in slowly - growing malignant tumors such as adenoid cystic carcinoma or lymphoma, and there was often associated bony destruction of other walls. Sclerosis was a common finding in the inflammatory process, especially in chronic maxillary sinusitis with bony destruction at the ostium of the medial wall, Sclerosis often occurred after radiotherapy and / or chemotherapy of tumors and was also noted when there was associated inflammation. Maxillary cysts showed characteristic expansion of all sinus walls. Bony changes were less prominent in the tumors of the nasal cavity compared to the changes seen in the maxillary lesions. A careful analysis of CT findings is very helpful in differentiating malignant from benign tumors and inflammatory disease in nasomaxillary lesions.

  18. Categorical course in neuroradiology. A. Abnormalities of the base of the skull and neck

    International Nuclear Information System (INIS)

    The skull base is the anatomic crossroad between the brain/meaninges above and the orbit, sinuses, and nasopharynx below. As such, in addition to pathologic processes intrinsic to the skull base itself, it can be affected by intracranial and extracranial lesions with involvement of or through the calvarial floor in either direction. The radiographic patterns and differential diagnosis of these transitional zone lesions will be presented by anatomic location. The comparative roles of CT and MR imaging in base-of-skull imaging will be discussed. Anterior cranial fossa lesions exemplified will include meningocephalocele and nasal glioma, tumors of the nasal vault and adjacent paranasal sinuses (including esthesioneuroblastomas, fibraomas, carcinomas, and fungal diseases), and meningiomas of the planum sphenoidale. Middle and posterior cranial fossa diseases (exclusive of pituitary fossa pathology) include both lytic and blastic lesions with or without a significant soft-tissue component. Middle fossa and clival meningiomas, chordomas, neutromas, giant cell tumor, histiocytosis X, metastatic disease, fibrous dysplasia, and Paget disease will be discussed. Lesions peculiar to the temporal boner region including congenital and acquired cholesteatomas, giant cholesterol cysts, neuromas of cranial nerves V, VI, VII, and VIII, and angiomas of the geniculate ganglion will be shown. A differential diagnosis of pharyngeal lesions will be presented that includes juvenile angiofibrpresented that includes juvenile angiofibroma, nasopharyngeal carcinoma, lymphoepithelioma, lymphoma, and adenoidal hypertrophy. Glomus tumors of the jugular region as well as those occurring in the neck, including glomus vagale and carotid body tumors, will be illustrated

  19. Usefulness and limitations of fluorine-18-fluorodeoxyglucose positron emission tomography for the detection of malignancy of orbital tumors

    International Nuclear Information System (INIS)

    Fluorine-18-fluorodeoxyglucose positron emission tomography ([18F]FDG PET) was assessed as a method for providing information about the malignancy of orbital tumors. Twelve patients with 13 orbital tumors underwent [18F]FDG PET followed by biopsy or tumor removal via a transcranial approach. The accumulation ratio between the tumor and the contralateral normal tissue (T/N ratio) was calculated for 10 of the 13 lesions. The T/N ratio in benign lesions was compared with that in malignant tumors. Histological examination identified 7 lesions as malignant: anaplastic astrocytoma of the optic nerve in 1 patient, which recurred as glioblastoma of the optic nerve, malignant lymphoma of mucosa-associated lymphoid tissue type in 1 patient, malignant melanoma in 1 patient, adenoid cystic carcinoma in 2 patients, and adenocarcinoma (unknown origin) in 1 patient. The T/N ratio was 1.06±0.03 (mean±standard deviation) in benign tumors, and significantly higher at 1.81±0.27 in malignant tumors (p=0.0027). Both patterns of high and iso uptake of [18F]FDG were found in orbital pseudotumor. [18F]FDG PET can determine the malignancy of orbital tumors, but cannot distinguish malignant tumor from inflammatory disease such as pseudotumor. (author)

  20. The Effect of Adenotonsillectomy on Children's Quality of life

    Science.gov (United States)

    Zojaji, Ramin; Mirzadeh, Morteza; Mazloum Farsi Baf, Morteza; Khorashadizadeh, Mostafa; Sabeti, Hamid Reza

    2014-01-01

    Introduction: Adenoid hypertrophy is the most common cause of chronic airway obstruction in children. The aim of this study was to evaluate the effect of adenotonsillectomy on sleep and behavioral disorders in children with adenotonsillar hypertrophy. Materials and Methods: In a prospective observational study, all children with an indication of adenotonsillectomy based on American Academy of Otolaryngology – Head and Neck Surgery criteria and sleep disorders referred to our otolaryngology clinic were enrolled and examined. Rutter Children’s Behavior (RCBQ) and Child Sleep Habit Questionnaires (CSHQ) were completed by the children’s parents both before and 3 months after the operation. Results: A total of 44 children (25 boys and 19 girls) with a mean (standard deviation [SD]) age of 7.86± 2.26 years and mean (SD) body mass index (BMI) of 16.37±1.35 kg/m2 were studied. Mean scores of RCBQ and CSHQ decreased significantly 3 months after adenotonsillectomy, and sleep habits and behavior improved significantly (P<0.05). Although there was no significant relationship between improvement of behavior and the gender, age or BMI of the children, there was a significant relationship between improvement of sleep habits and age as well as BMI (P<0.05). Conclusion: As adenotonsillectomy causes significant improvements in children`s quality of life (including sleep and behavior), it is recommended in children with adenotonsillar hypertrophy. PMID:25320696

  1. Radiation and thyroid neoplasia

    International Nuclear Information System (INIS)

    It is now generally accepted that an association exists between external radiation administered to the head, neck, and upper thorax of infants, children, and adolescents and the subsequent development of neoplastic changes in the thyroid gland. Until recent years, external radiation was frequently administered to shrink an enlarged thymus or for the treatment of tonsillitis, adenoiditis, hearing loss, hemangioma, acne, tinea capitis, and other conditions. During the course of these treatments, the thyroid gland was exposed to scatter radiation. The use of external radiation therapy was then accepted practice, and its value was attested by many. Concern about the adverse effects was not initially appreciated, primarily because of the long periods of time between the radiation and the recognition of changes in the thyroid. The availability and effectiveness of other therapeutic measures and the growing concern about the delayed effects of radiation therapy when administered to the young for relatively benign conditions has, in recent years, largely eliminated use of this form of therapy, except in a few unusual conditions

  2. The role of stereotactic radiosurgery in the treatment of malignant skull base tumors

    International Nuclear Information System (INIS)

    Purpose: To determine the efficacy and toxicity of stereotactic radiosurgery in the treatment of malignant skull base tumors. Methods and Materials: Thirty-two patients with 35 newly diagnosed or recurrent malignant skull base tumors ?33.5 cm3 were treated using the Leksell Gamma unit. Tumor histologies included: adenoid cystic carcinoma, basal cell carcinoma, chondrosarcoma, chordoma, nasopharyngeal carcinoma, osteogenic sarcoma, and squamous cell carcinoma. Results: After a median follow-up of 2.3 years, 83% ± 15% (±95% confidence interval) of patients experienced a symptomatic response to treatment. Local control at the skull base was 95 ± 9% at 2 years and 78 ± 23% at 3 years. Local-regional control above the clavicles was 75 ± 15% at 1 year and 51 ± 20% at 2 years. Overall and cause specific survival were identical, 82 ± 13% at 1 year, 76 ± 14% at 2 years, and 72 ± 16% at 3 years. One patient developed a radiation-induced optic neuropathy 12 months after radiosurgery. Conclusion: Stereotactic radiosurgery using the Leksell Gamma Unit can provide durable tumor control and symptomatic relief with acceptable toxicity in the majority of patients with malignant tumors 4 cm or less in size involving the skull base. Further evaluation of more patients with longer follow-up is warranted

  3. Immunohistochemical characterization of the differentiation state of basal cell carcinomas with special interest for infiltrating relapsing tumors.

    Science.gov (United States)

    Barbaud, A; Simon, M; Parache, R M; Serre, G

    1998-01-01

    A retrospective histological and immunohistochemical study was performed on 66 basal cell carcinomas (BCC). To determine the differentiation stages of epithelial cells in these BCC, three monoclonal antibodies directed against cytokeratins K1, K2, K9 and K10-11 (EE21-06), to cytokeratins K1 to K19 (F12-19), and to corneodesmosin (G36-19) were used in indirect immunofluorescence on paraffin-embedded sections. Three histological groups of BCC with specific cytokeratin immunohistochemical features were distinguished: (1) superficial BCC were unlabelled, (2) nodular and variant (keratotic, adenoid) BCC showed an homogeneous labelling, and (3) infiltrative aggressive-type BCC showed a heterogeneous cell to cell labelling. Some nodular BCC cells presented characteristics of granular keratinocytes, i.e. they were labelled by the anticorneodesmosin antibody. All the clinically recurrent tumors were found to be of the infiltrative aggressive-type. If these aggressive forms of BCC were not identified by specific marker, their topographic patterns of labeling with antibodies directed to cytokeratins allowed them to be distinguished. We suggest that an immunohistochemical analysis with antibodies specific for different stages of keratinocyte differentiation is an efficient complement to histological diagnosis of BCC. PMID:9683887

  4. Utility of a Herpes Oncolytic Virus for the Detection of Neural Invasion By Cancer

    Directory of Open Access Journals (Sweden)

    Ziv Gil

    2008-04-01

    Full Text Available Prostate, pancreatic, and head and neck carcinomas have a high propensity to invade nerves. Surgical resection is a treatment modality for these patients, but it may incur significant deficits. The development of an imaging method able to detect neural invasion (NI by cancer cells may guide surgical resection and facilitate preservation of normal nerves. We describe an imaging method for the detection of NI using a herpes simplex virus, NV1066, carrying tyrosine kinase and enhanced green fluorescent protein (eGFP. Infection of pancreatic (MiaPaCa2, prostate (PC3 and DU145, and adenoid cystic carcinoma (ACC3 cell lines with NV1066 induced a high expression of eGFP in vitro. An in vivo murine model of NI was established by implanting tumors into the sciatic nerves of nude mice. Nerves were then injected with NV1066, and infection was confirmed by polymerase chain reaction. Positron emission tomography with [18F]-2?-fluoro-2?-deoxyarabinofuranosyl-5-ethyluracil performed showed significantly higher uptake in NI than in control animals. Intraoperative fluorescent stereoscopic imaging revealed eGFP signal in NI treated with NV1066. These findings show that NV1066 may be an imaging method to enhance the detection of nerves infiltrated by cancer cells. This method may improve the diagnosis and treatment of patients with neurotrophic cancers by reducing injury to normal nerves and facilitating identification of infiltrated nerves requiring resection.

  5. The comparison study between FDG fusion PET and CT in patients with confirmed salivary gland cancer

    International Nuclear Information System (INIS)

    It is well known that FDG Fusion PET (PET) has a good diagnostic nature in patient with head and neck cancer. But, there is a few PET study about salivary gland cancer which had a different histopathology. We analyzed the usefulness of PET in patients with biopsy confirmed salivary gland cancer. Eleven patients (M: F=8: 3, age = 61.29.3 yr) with PET and CT exam were enrolled (The interval=4263 day). All of them didn't have previous chemotherapy or radiotherapy. PET and CT were compared with pathologic TNM stage. All of eleven patients had salivary gland biopsy and confirmed as malignancy (parotid gland: submandibular gland =8: 3). Pathologic type was adenocarcinoma (1), poor differentiated carcinoma (1), mucoepidermoid carcinoma (n=2), adenoid cystic carcinoma (2), salivary duct carcinoma (2), carcinoma ex pleomorhic adenoma (3). One patient didn't operation due to metastatic lesions which was detected on PET. From 10 patients, PET had a 100 % of tumor detection rate (maxSUV =4.72.1) and 60 %(6/10) of coincident result with pathologic N stage. CT had 100 % of tumor detection rate and 40% (4/10) and 60 % (6/10) of coincidence results with TN stage. Even though PET didn't have a better coincidence with pathologic N stage than that of CT, it is useful method to discriminate metastatic lesion

  6. Craniofacial differences according to AHI scores of children with obstructive sleep apnoea syndrome: cephalometric study in 39 patients

    Energy Technology Data Exchange (ETDEWEB)

    Oezdemir, Hueseyin; Mahmutyaziciglu, Kamran; Davsancimath, Halit; Guendogdu, Sadi [Department of Radiology, Medical School, Zonguldak Karaelmas University, Kozlu, 67600, Zonguldak (Turkey); Altin, Remzi; Kart, Levent [Department of Pulmonology, Medical School, Zonguldak Karaelmas University (Turkey); Soeguet, Ayhan; Tomac, Nazan [Department of Paediatrics, Medical School, Zonguldak Karaelmas University (Turkey); Cinar, Fikret; Uzun, Lokman [Department of Otolaryngology, Medical School, Zonguldak Karaelmas University, (Turkey)

    2004-05-01

    Cephalometry is useful as a screening test for anatomical abnormalities in patients with obstructive sleep apnoea syndrome (OSAS). To evaluate comprehensively the cephalo metric features of children with OSAS, with or without adenotonsillar hypertrophy, and to elucidate the relationship between cephalometric variables and apnoea-hypopnoea index (AHI) severity. The study population consisted of 39 children, aged 4-12 years, with OSAS. Cephalometry was analysed using 11 measurements of the bony structures, their relationships and the size of the airways. Additionally, adenoid and tonsillar hypertrophy were graded. Cranial base angles (BaSN and BaSPNS) were found to correlate with increasing levels of AHI scores (P<0.001). Protrusion of the maxilla (SNA) and mandible (SNB) did not correlate with AHI scores (P>0.05). The length of the mandibular plane (GnGo) and the minimal posterior airway space (MPAS) were inversely correlated with AHI scores (P<0.001). There was positive correlation between MPAS and GnGo (r=0.740, P<0.001), and negative correlation between MPAS and gonial angle (ArGoGn) (r=-0.541, P<0.001). There was significant correlation between cephalometric data and adenotonsillar hypertrophy concerning BaSN, BaSPNS, ArGoGn, GnGoH, BaN-GnGo, MPAS, GnGO and MPH. (orig.)

  7. Craniofacial differences according to AHI scores of children with obstructive sleep apnoea syndrome: cephalometric study in 39 patients

    International Nuclear Information System (INIS)

    Cephalometry is useful as a screening test for anatomical abnormalities in patients with obstructive sleep apnoea syndrome (OSAS). To evaluate comprehensively the cephalo metric features of children with OSAS, with or without adenotonsillar hypertrophy, and to elucidate the relationship between cephalometric variables and apnoea-hypopnoea index (AHI) severity. The study population consisted of 39 children, aged 4-12 years, with OSAS. Cephalometry was analysed using 11 measurements of the bony structures, their relationships and the size of the airways. Additionally, adenoid and tonsillar hypertrophy were graded. Cranial base angles (BaSN and BaSPNS) were found to correlate with increasing levels of AHI scores (P0.05). The length of the mandibular plane (GnGo) and the minimal posterior airway space (MPAS) were inversely correlated with AHI scores (P<0.001). There was positive correlation between MPAS and GnGo (r=0.740, P<0.001), and negative correlation between MPAS and gonial angle (ArGoGn) (r=-0.541, P<0.001). There was significant correlation between cephalometric data and adenotonsillar hypertrophy concerning BaSN, BaSPNS, ArGoGn, GnGoH, BaN-GnGo, MPAS, GnGO and MPH. (orig.)

  8. The Diagnostic Value of Computed Tomography in Head and Neck Cancer Part I : Nasopharyngeal Carcinoma

    International Nuclear Information System (INIS)

    The CT findings of 46 cases of nasopharyngeal cancer were analyzed and compared with clinical tumor staging. They are composed of 28 cases (61%) of squamous cell carcinoma, 13 cases (28%) of undifferentiated carcinoma, 4 cases (9%) of lymphoma and 1 case (2%) of adenoid cystic carcinoma. The results were as follows: 1. The most common CT finding of nasopharyngeal cancers are air-way asymmetry including obliteration of Rosenmuller fossa, orifice of Eustachian tube and asymmetric obliteration of parapharyngeal fat. 2. Other involved anatomic sites are carotid sheath area, oropharynx, paranasal sinuses especially sphenoid sinus, cervical lymph nodes, nasal cavity and skull base or middle cranial fossa. 3. CT dose significantly influence on the tumor staging of the nasopharynx cancers, but has a definite value in evaluating deep tissue invasion of the cancers especially to parapharyngeal space or carotid sheath area. 4. CT seems to be essential for staging work-up, estimating the prognosis, and assessing the effect of radiotherapy of the nasopharyngeal cancer because it clearly shows the whole extent of the tumors including deep tissue invasion

  9. Fine needle aspiration cytology of parapharyngeal tumors

    Directory of Open Access Journals (Sweden)

    Mondal Palash

    2009-01-01

    Full Text Available Background: Parapharyngeal tumors are rare and often pose diagnostic difficulties due to their location and plethora of presentations. Objectives: The study was undertaken to study the occurrence in the population and to evaluate the exact nature by fine needle aspiration cytology (FNAC. Materials and Methods: A total of five hundred and six cases of lateral neck lesions were studied over three and half years. Of these 56 suspected parapharyngeal masses were selected by clinical and radiological methods. Cytopathology evaluation was done by fine needle aspiration cytology with computed tomography and ultrasonography guidance wherever necessary. Histopathology confirmation was available in all the cases. Results: On FNAC diagnosis could be established in 54 cases while in two cases the material was insufficient to establish a diagnosis. The tumors encountered were, pleomorphic adenoma (33, schwannoma (3, neurofibroma (11, paraganglioma (5, angiofibroma (1 and adenoid cystic carcinoma (1. Four false positives and two false negative cases were encountered. Overall sensitivity was 96%, with specificity of 99% and accuracy being 98.8%. Conclusions: With proper clinical and radiological assessment, FNAC can be extremely useful in diagnosing most of these lesions except a few which need histopathological and even immunohistochemical confirmation.

  10. The Diagnostic Value of Computed Tomography in Head and Neck Cancer Part I : Nasopharyngeal Carcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Yul; Suh, Chang Hae; Chang, Kee Hyun [Seoul National University College of Medicine, Seoul (Korea, Republic of)

    1984-06-15

    The CT findings of 46 cases of nasopharyngeal cancer were analyzed and compared with clinical tumor staging. They are composed of 28 cases (61%) of squamous cell carcinoma, 13 cases (28%) of undifferentiated carcinoma, 4 cases (9%) of lymphoma and 1 case (2%) of adenoid cystic carcinoma. The results were as follows: 1. The most common CT finding of nasopharyngeal cancers are air-way asymmetry including obliteration of Rosenmuller fossa, orifice of Eustachian tube and asymmetric obliteration of parapharyngeal fat. 2. Other involved anatomic sites are carotid sheath area, oropharynx, paranasal sinuses especially sphenoid sinus, cervical lymph nodes, nasal cavity and skull base or middle cranial fossa. 3. CT dose significantly influence on the tumor staging of the nasopharynx cancers, but has a definite value in evaluating deep tissue invasion of the cancers especially to parapharyngeal space or carotid sheath area. 4. CT seems to be essential for staging work-up, estimating the prognosis, and assessing the effect of radiotherapy of the nasopharyngeal cancer because it clearly shows the whole extent of the tumors including deep tissue invasion.

  11. Análisis epidemiológico de la patología otorrinolaringológica ambulatoria en el Hospital San Juan de Dios / Epidemiological analysis of otolaryngology outpatient pathology at San Juan de Dios's Hospital

    Scientific Electronic Library Online (English)

    Samanta, Ruz G; Hayo, Breinbauer K; Margarita, Arancibia S.

    2009-12-01

    Full Text Available SciELO Chile | Language: Spanish Abstract in spanish Introducción: La patología otorrinolaringológica presenta una alta incidencia. Objetivo: Conocerla frecuencia de consultas permite crear programas de formación continua adecuados. Material y método: Estudio retrospectivo. Análisis de las hojas de atención de policlfnico ambulatorio durante el año 20 [...] 06 en el Hospital San Juan de Dios. Resultados: La patología más frecuente es la otológica, que corresponde a 50% de las consultas. Individualmente, la patología más común es la otitis media crónica, seguida de la patología adenoamigdalina y la rinitis. Conclusiones: Ha habido un desplazamiento de la patología infecciosa hacia la patología crónica inflamatoria. Abstract in english Introduction: The otolaryngology pathology has a high incident. Aim: To know the outpatient pathology frequency that allows the creation of suitable permanent training programs. Methods: Retrospective study. Analysis of outpatient daily attention sheets during 2006 at San Juan de Dios's Hospital. Re [...] sults: The most frequent pathology is the otologic, which represents 50% of the consultations. Individually, the most common pathology is chronic otitis media, followed tonsilar and adenoid pathology and rhinitis. Conclusions: There has been a displacement of the infectious pathology towards the chronic inflammatory pathology.

  12. The Rare Cancer Network: achievements from 1993 to 2012.

    Science.gov (United States)

    Patel, Ajaykumar; Ozsahin, Mahmut; Mirimanoff, Rene-Olivier; Bhatia, Sumita; Chang, Kenneth; Miller, Robert Clell

    2012-06-26

    The Rare Cancer Network (RCN), founded in 1993, performs research involving rare tumors that are not common enough to be the focus of prospective study. Over 55 studies have either been completed or are in progress.The aim of the paper is to present an overview of the 30 studies done through the RCN to date, organized by disease site. Five studies focus on breast pathology, including sarcoma, lymphoma, phyllodes tumor, adenoid cystic carcinoma, and ductal carcinoma in situ in young women. Three studies on prostate cancer address prostatic small cell carcinoma and adenocarcinoma of young and elderly patients. Six studies on head and neck cancers include orbital and intraocular lymphoma, mucosal melanoma, pediatric nasopharyngeal carcinoma, olfactory neuroblastoma, and mucosa-associated lymphoid tissue lymphoma of the salivary glands. There were 4 central nervous system studies on patients with cerebellar glioblastoma multiforme, atypical and malignant meningioma, spinal epidural lymphoma and myxopapillary ependymoma. Outside of these disease sites, there is a wide variety of other studies on tumors ranging from uterine leiomyosarcoma to giant cell tumors of the bone. The studies done by the RCN represent a wide range of rare pathologies that were previously only studied in small series or case reports. With further growth of the RCN and collaboration between members our ability to analyze rare tumors will increase and result in better understanding of their behavior and ultimately help direct research that may improve patient outcomes. PMID:23087791

  13. Stereotactic gamma radiosurgery of brain tumors

    International Nuclear Information System (INIS)

    One thousand cases with various head and neck diseases have been treated by gamma radiosurgery at Komaki City Hospital since May 1991. Five hundred and sixty-eight out of 1,000 cases were neoplastic lesions which consisted of 173 cases of neurinoma, 108 of metastatic tumors, 103 of meningioma, 69 of gliomas, 27 of pituitary adenoma, 26 of craniopharyngioma, 13 of pineal tumors, 11 of chordoma, 6 of malignant lymphoma, 5 of hemangioblastoma and so on. The most effective result has been shown in metastatic brain tumors. The complete response (disappearance of the lesion) was obtained in more than 50% of the treated lesions, and the control rate of 85% was maintained for more than 12 months. Next effective results were shown in craniopharyngioma, malignant pineal tumors and malignant lymphoma. There was a group which showed moderate response but no tumor disappearance. Those were pituitary adenoma, acoustic neurinoma, meningioma and chordoma. Gliomas showed less response and even progression of tumor at relatively higher rate. It has been found that malignant gliomas showed difficult control of the tumor and progression rate of 70%, while benign gliomas showed the control rate of more than 90%. Besides intracranial lesions, malignant skull base tumors such as chordoma, naso-pharyngeal cancer, adenoid cystic cancer showed better response to gamma radiosurgery and higher control rate for longer period of time with high QOL compaired to conventional irradiation. (author)d to conventional irradiation. (author)

  14. MRI of salivary gland tumors

    Energy Technology Data Exchange (ETDEWEB)

    Ariyoshi, Yasunori; Shimahara, Masashi; Senda, Jyunko; Sakinaka, Isao [Osaka Medical Coll., Takatsuki (Japan); Nakano, Yoshinobu

    1996-04-01

    MRI findings of 13 patients with proven salivary gland tumors, including 7 cases of parotid gland tumors, 2 cases of submandibular gland tumors, and 4 cases of minor salivary gland tumors, were reviewed. All examinations were carried out on a 1.5-T MRI system (General Electric, SIGNA Performance plus and SIMAZU, SMT-150X) with spin echo sequence. T1 and T2 weighted images and Gd-DTPA enhanced T1 weighted images were obtained. The results were as follows: All tumors demonstrated low to intermediate signal intensity on T1 weighted images and intermediate to high signal intensity on T2 weighted images. The differences between malignant and benign tumors were not detected by means of the signal intensity of the tumors. Tumor margins were clear except for 2 cases, including inflamed pleomorphic adenoma of the submandibular gland and adenoid cystic carcinoma of the parotid gland. Except for the case of adenolymphoma, internal structures of the tumor are inhomogenous, especially on T2 weighted images. Although the intraparotid facial nerve is not detected directly, whether the tumor is located on superficial or deep lobe could be detected by drawing a line between the lateral surface of the posterior belly of the digastric muscle and the lateral posterior border of the mandible except for one case and using the retromandibular vein except for two cases. (author).

  15. Salivary duct carcinoma ex pleomorphic adenoma of the palate: a case report.

    Science.gov (United States)

    Bourell, Lauren G; Chan, King Chong; Hirsch, David L

    2015-02-01

    Carcinoma ex pleomorphic adenoma is a rare malignancy of the head and neck, particularly in the minor salivary glands. Most cases arise in the major salivary glands, most commonly in the parotid gland, followed by the submandibular gland. The malignant component of the tumor varies, but can be salivary duct carcinoma, adenoid cystic carcinoma, mucoepidermoid carcinoma, squamous cell carcinoma, or adenocarcinoma, not otherwise specified. Primary salivary duct carcinoma is also a rare malignancy of the head and neck. Similar to carcinoma ex pleomorphic adenoma, it is more common in the major salivary glands, with the parotid gland accounting for 88% and the submandibular gland for 10% of cases. To date, only 25 known cases of primary salivary duct carcinoma arising in the minor salivary glands have been documented, with most arising in the palate. Salivary duct carcinoma ex pleomorphic adenoma of the minor salivary glands appears to be even rarer. Our case of salivary duct carcinoma ex pleomorphic adenoma of the palate is the first complete report, to our knowledge, in the English-language scientific literature. PMID:25579019

  16. Salivary gland tumors in a Brazilian population: a retrospective study of 124 cases

    Directory of Open Access Journals (Sweden)

    Vargas Pablo Agustin

    2002-01-01

    Full Text Available Salivary gland tumors constitute a highly heterogeneous histopathologic group. There are few epidemiological studies of large series of benign and malignant salivary gland tumors in Brazil. MATERIAL AND METHODS: Hospital records of 124 patients with salivary gland tumors diagnosed from January 1993 to December 1999 were reviewed. The patients were analyzed according to gender, age, size, location, and histopathology of the tumor. RESULTS AND CONCLUSIONS: Patients with benign and malignant tumors presented with a mean age of 47.7 and 48.8 years, respectively. The frequency of benign tumors was 80% (n = 99 and malignant tumors 20% (n = 25. Tumors were localized in the parotid gland 71% (n = 88, in the submandibular gland 24% (n = 30, and in the minor salivary glands 5% (n = 6. The most common benign tumors were pleomorphic adenoma in 84% (n = 84 and Warthin's tumor in 13% (n = 13. Among malignant tumors, mucoepidermoid carcinoma was the most common in 52% (n = 13, adenoid cystic carcinoma occurred in 20% (n = 5, and carcinoma ex pleomorphic adenoma was detected in 12% (n = 3.

  17. Salivary gland tumors in children: a retrospective clinical review.

    Science.gov (United States)

    Varan, Ali; Akyüz, Canan; Ata?, Erman; Yücel, Ta?k?n; Ayd?n, Burça; Yalç?n, Bilgehan; Kutluk, Tezer; Büyükpamukçu, Münevver

    2014-11-01

    Seven patients with salivary gland tumors who underwent between 1972 and 2012 were retrospectively evaluated. The age of the patients ranged from 6.3 to 13 years old; five were females and two were males. Five patients had stage IVa, one patient had stage I, and one patient had stage II disease. The surgical margin was found to be positive in five cases. There were three adenoid cystic carcinoma, two adenocarcinoma, one anaplastic carcinoma, and one mucoepidermoid carcinoma. There were five parotid, one lacrimal gland, and one palatal involvement. Three patients who had low stage tumors were treated with surgery alone. Four of the cases received adjuvant radiation and chemotherapy. One patient with parotid tumor died with progressive disease. One case with lacrimal gland neoplasm was alive 48 months after discontinuation of treatment. The other palate case was lost to follow-up 1 month after the beginning of the treatment. Surgery is the primary treatment, with radiotherapy and chemotherapy used as adjuvant treatments. The treatment options need to be selected and planned for each individual patient. PMID:25247345

  18. Characterization of patients with epithelial malignant parotid tumor who received radiation treatment. INOR. 1992-2005

    International Nuclear Information System (INIS)

    To characterize patients diagnosed with epithelial malignant parotid tumor were treated at the National Institute of Oncology and Radiobiology, took out an observational, descriptive, longitudinal and retrospective at the hospital radiotherapy department. During the period from 1992 to 2005, a total of 92 diagnosed patients with this disease who were treated with radiation therapy and met the inclusion criteria for the sample. We use the absolute and relative frequencies values in descriptive studies and summary measures for quantitative variables. Predominant group of 65 years and older, male sex and family history of cancer. The tumor, pain and clinical stages II and IV were the clinical features that stood out, with frequent histopathological diagnosis of muco epidermoid carcinoma and adenocarcinoma. Surgery and radiotherapy concurrent with chemotherapy were conducted in a large proportion of cases, with the intermediate grade, high or adenoid cystic tumor reason prevailed in the indication of radiotherapy, adjuvant and dosage form 50 to 56 Gy , appearing as the most frequent complication radiodermatitis. (Author)

  19. The comparison study between FDG fusion PET and CT in patients with confirmed salivary gland cancer

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Bom Sahn; Gang, Won Jun; Oh, So Won; Lee, Jeong Won; Lee, Dong Soo; Chung, June Key; Lee, Myung Chul [Seoul National Univ. College of Medicine, Seoul (Korea, Republic of)

    2007-07-01

    It is well known that FDG Fusion PET (PET) has a good diagnostic nature in patient with head and neck cancer. But, there is a few PET study about salivary gland cancer which had a different histopathology. We analyzed the usefulness of PET in patients with biopsy confirmed salivary gland cancer. Eleven patients (M: F=8: 3, age = 61.29.3 yr) with PET and CT exam were enrolled (The interval=4263 day). All of them didn't have previous chemotherapy or radiotherapy. PET and CT were compared with pathologic TNM stage. All of eleven patients had salivary gland biopsy and confirmed as malignancy (parotid gland: submandibular gland =8: 3). Pathologic type was adenocarcinoma (1), poor differentiated carcinoma (1), mucoepidermoid carcinoma (n=2), adenoid cystic carcinoma (2), salivary duct carcinoma (2), carcinoma ex pleomorhic adenoma (3). One patient didn't operation due to metastatic lesions which was detected on PET. From 10 patients, PET had a 100 % of tumor detection rate (maxSUV =4.72.1) and 60 %(6/10) of coincident result with pathologic N stage. CT had 100 % of tumor detection rate and 40% (4/10) and 60 % (6/10) of coincidence results with TN stage. Even though PET didn't have a better coincidence with pathologic N stage than that of CT, it is useful method to discriminate metastatic lesion.

  20. Pitfalls of fine-needle aspiration cytology of parotid membranous basal cell adenoma-A review of pitfalls in FNA cytology of salivary gland neoplasms with basaloid cell features.

    Science.gov (United States)

    Jurczyk, Matthew; Peevey, Joseph F; Vande Haar, Mark A; Lin, Xiaoqi

    2014-11-27

    Membranous basal cell adenoma (MBCA) is a rare benign salivary gland neoplasm. It is difficult to diagnose MBCA based on fine-needle aspiration (FNA) cytology due to rare reporting of its FNA cytology and overlapping of its FNA cytologic features with some benign and malignant entities. We present a case of MBCA in a 67-year-old female that was originally misinterpreted as adenoid cystic carcinoma (ACC) on FNA cytology. The FNA smears showed numerous uniform small basaloid epithelial cells with round or oval nuclei and inconspicuous nucleoli, and scant cytoplasm. The basaloid cells surround acellular, dense, homogenous material or are surrounded by acellular or paucicellular dense homogeneous material possibly containing bland spindle cells. The basaloid cells are present in variably sized three-dimensional clusters, acini, or sheets with variable cohesion. The dense homogenous material surrounded by basaloid cells may be interconnected. High power magnification reveals the homogeneous material to have a fibrillar texture. The edges of dense homogenous materials were well-demarcated. We describe the diagnostic pitfalls of FNA for MBCA, particularly versus ACC, basal cell adenoma, cellular pleomorphic adenoma, myoepithelioma, basal cell adenocarcinoma, and basaloid squamous cell carcinoma in hope of improving clinical management and patient treatment. Diagn. Cytopathol. 2014; © 2014 Wiley Periodicals, Inc. PMID:25431027

  1. The role of postoperative radiation therapy in carcinoma ex pleomorphic adenoma of the parotid gland

    International Nuclear Information System (INIS)

    Purpose: To evaluate the impact of postoperative radiation therapy on the clinical course of patients with carcinoma ex pleomorphic adenoma of the parotid gland. Methods and Materials: Between 1960 and 2004, 63 patients were treated with definitive surgery for carcinoma ex pleomorphic adenoma of the parotid gland. Forty patients (63%) received postoperative radiation therapy to a median dose of 60 Gy (range, 45-71 Gy). Adenocarcinoma (29 patients), salivary duct carcinoma (16 patients), and adenoid cystic carcinoma (9 patients) were the most common malignant subtypes. Pathologic T -stage was: 16% T1, 33% T2, 32% T3, and 19% T4. Twenty-one patients (33%) had microscopically positive margins and 39 (62%) had perineural invasion. Median follow-up was 50 months (range, 2-96 months). Results: The use of postoperative therapy significantly improved 5-year local control from 49% to 75% (p = 0.005) and was associated with an improvement in survival among patients without evidence of cervical lymph node metastasis (p = 0.01). A Cox proportional hazard model identified pathologic involvement of cervical lymph nodes as an independent predictor of overall survival. Overall survival was 16% for patients with pathologic N-positive disease compared with 67% for those whose lymph node status was negative or unknown (p = 0.001). Conclusion: Surgery followed by postoperative radiation should be considered the standard of care for patients with carcinoma ex pleomorphic adenomacarcinoma ex pleomorphic adenoma

  2. Magnetic resonance imaging of the parotid gland

    International Nuclear Information System (INIS)

    Pathological lesions of the parotid gland were examined comparatively with different examination sequences both plain and with the contrast medium Gd-DTPA. There were 36 benign lesions (parotitis, Sjoegren's syndrome, adenoma, etc.) and 24 malignant tumours (squamous cell carcinoma, adenocarcinoma, adenoid cystic carcinoma etc.) Examinations were carried out at 1.0 T with long and short spin echo sequences in transverse and frontal layer orientation before and after application of Gd-DTPA as contrast medium. In the patients suffering from parotitis the best results were obtained with plain T1 and T2 sequences; the contrast medium Gd-DTPA bemained without superior diagnostic relevance. However, in Sjoegren's syndrome (myoepithelial sialadenitis) administration of the contrast medium alwys yielded a characteristic honeycomblike pattern. In benign and malignant space-occupying growths MRI supplied additional diagnostic information with Gd-DTPA in respect of defining the tumour borderlines and paths of infiltration. MRI is now a significant diagnostic tool in inflammatory and tumorous lesions of the parotid gland. (orig.)

  3. Tumores de glándulas salivales: Nuestra experiencia

    Scientific Electronic Library Online (English)

    Enrique, Pérez Abreus; Pedro, Ordúñez García; Ángel Luis, Cruz Leyva.

    2000-08-01

    Full Text Available Se realiza una investigación aplicada descriptiva longitudinal con todos los pacientes portadores de tumores de glándulas salivales que necesitaron tratamiento quirúrgico en el Servicio de Cirugía Maxilofacial del Hospital Universitario Clinicoquirúrgico "Dr. Gustavo Aldereguía" de Cienfuegos, duran [...] te el período de enero de 1990 a diciembre de 1999. Se observó un predominio del sexo femenino, así como del grupo etario de mayores de 60. La glándula más afectada fue la parótida, dentro de los adenomas, el pleomorfo fue el de mayor frecuencia, mientras que el carcinoma adenoideo quístico lo fue en el grupo de los carcinomas. La cirugía fue la principal arma terapéutica, seguida de la combinación quirúrgicaradiante. Además se analizan algunos esquemas de quimioterapia. Abstract in english An applied descriptive and longitudinal investigation was made with all the patients carriers of salivary gland tumors that needed surgical treatment at the Maxillofacial Surgery Service of "Dr. Gustavo Aldereguía" Clinical and Surgical Teaching Hospital, in Cienfuegos, from January, 1990, to Decemb [...] er, 1999. It was observed a predominance of females as well as of the age group over 60. The parotid gland was the most affected, whereas the pleomorphic salivary adenoma was the commonest. The adenoid cystic carcinoma was the most frequent in the group of carcinomas. Surgery was the main treatment used, followed by the surgical-radiant combination. Some drug therapy schemes were also analyzed.

  4. A retrospective review of 139 major and minor salivary gland tumors.

    Science.gov (United States)

    Trenki? Božinovi?, Marija; Krasi?, Dragan; Kati?, Vuka; Krsti?, Miljan

    2015-02-01

    Aim To describe demographic and histomorphological characteristics of 139 patients with epithelial salivary gland tumors in the Southeastern Serbia population. Methods A total number of 139 patients with epithelial tumors arising in major and minor salivary glands in the period 2010-2012 was evaluated. After standard tissue proceeding, the routine haematoxylin-eosin (HE) and histochemical alcian blue-periodic acid-Schiff (AB - PAS) methods were used for histomorphological examination. Results Among 139 patients, 102 (73.38%) had benign, and 37 (26.62%) malignant tumors. The majority of tumors were localized in the parotid gland, in 117 (84.17%) patients. Among benign tumors there were 50 (49.02%) pleomorphic adenoma, 48 (47.06%) Warthin's tumor, two (1.96%) myoepithelioma, and two (1.96%) oncocytoma. In the group of malignant tumors the most common was mucoepidermoid carcinoma, in 12 (32.43%) patients, carcinoma ex pleomorphic adenoma in six (16.22%), adenoid cystic carcinoma in five (13.51%), and oncocytic carcinoma in three (8.11%) patients. Conclusion Benign tumors were more common than malignant ones, with predominance of pleomorphic adenoma. Malignant tumors are less common than benign in the large salivary glands, and more common in the minor salivary glands. Histochemical AB-PAS method helps in the diagnosis of mucinous salivary gland carcinoma. Key words: benign, carcinoma, epidemiology, histopathology. PMID:25669341

  5. Malignant parotid tumors in 110 consecutive patients: treatment results and prognosis

    DEFF Research Database (Denmark)

    Pedersen, Dorte; Overgaard, Jens

    1992-01-01

    The UICC 1987 classification system was used to retrospectively analyze the treatment results and prognostic factors in 110 consecutive patients. All of the patients had malignant parotid tumors which had been diagnosed and treated during the period from 1970 to 1986. Treatment consisted of surgery, radiotherapy, or a combination. Malignant mixed tumors were seen in 28% of the patients, mucoepidermoid tumors in 18%, adenoid cystic tumors in 15%, acinic tumors in 13%, undifferentiated tumors in 11%, adenocarcinomas in 10%, and other types in 5%. Ten-year corrected survival rate was 52%, and significant differences of survival were found between: 1. patients with disease stages I through IV (I: 85%; II: 69%; III: 43%; IV: 14%); 2. those with local tumor extension (34%) and without local tumor extension (79%); 3. patients with facial nerve palsy (0%) and without facial nerve palsy (57%); and 4. those with low- or intermediate-grade malignant tumors (69% combined) and those with high-grade malignant tumors (30%).After primary treatment, 45% of the patients were cured, and, additionally, 22% were salvaged after local or neck node recurrences. It is concluded that there is a good correlation between TNM classification of UICC 1987 (stage and local extension of tumor) and prognosis, and that facial nerve palsy and grade of malignancy are important prognostic factors.

  6. CT findings of parotid gland tumors: benign versus malignant tumors

    International Nuclear Information System (INIS)

    The purpose of this study is to evaluate the characteristics of parotid gland tumors to help in the differentiation between benign and malignant lesions. The CT findings of 22 patients with surgically proven parotid gland tumors were reviewed. Analysis was focused on the density and margin characteristics of the tumors, and the relationship between the tumor and surrounding structures. Those tumors were pleomorphic adenoma (n = 8), Warthin's tumor (n = 5), basal cell adenoma (n = 1), lipoma (n = 1), dermoid cyst (n = 1), adenoid cystic carcinoma (n = 2), mucoepidermoid carcinoma (n 1), epidermoid carcinoma (n = 1), and carcinoma in pleomorphic adenoma (n 1). Most of benign and malignant tumors were heterogeneous in density on contrast enhanced CT scans. In 5 of 6 malignant cases, the tumors had irregular or ill-defined margin and a tendancy to involve or cross the superficial layer of deep cervical fascia with obliteration of subcutaneous fat. Two malignant tumors invaded surrounding structures. Although the heterogeneous density of tumor is not a specific finding for malignancy at CT, following findings, such as, irregular or blurred margin of the lesion, the involvement of fascial plane, and the infiltration of surrounding structures may suggest the possibility of malignant parotid tumor

  7. Radiation Therapy in Malignant Tumors of the Parotid Gland

    International Nuclear Information System (INIS)

    A retrospective analysis was performed on 55 patients with malignant parotid tumor who were treated with radiation therapy between March, 1979 and July, 1989. Of these patients, 8 patients received radiation therapy(RT) alone and 47 patients were treated with combined operation and radiation therapy(OP+RT). The follow-up period of the survivors ranged form 1 to 129 months with a median of 48 months. The common histologic types were mucoepidermoid carcinoma (25 cases), malignant mixed tumor(12 cases), adenoid cystic carcinoma(6 cases). The 5 and 10 year local control rate were 69.8% and 65.7% in all patients. In OP+RT group, prognostic factors related to local control were histologic grade, tumor size, lymph node metastasis. Resection of facial nerve did not affect the local control rate significantly(p=0.129). Distant metastasis developed in 23.6% of patients, mostly to the lung. Actuarial overall survival rate was 72.2% at 10 years and formed plateau after 5 years. Disease-free (NED) survival rate was 49.4% at 10 years and was better achieved in OP+RT group and low grade lesions. Based on our result, a well planned postoperative RT following parotidectomy is highly efficacious in controlling malignant tumors of the parotid gland and preservation of facial nerve

  8. MALIGNANT SALIVARY GLAND TUMORS

    Directory of Open Access Journals (Sweden)

    Violeta Trandafir

    2010-05-01

    Full Text Available Malignant salivary gland tumors make up 6% of all head and neck tumors. Several types of cancer can develop in these glands. Only malignant tumors of the salivary glands are discussed in this paper. The diagnosis and treatment of salivary gland malignancies remain complex, with challenging problems for maxillo-facial surgeon. Scientists have found few risk factors that make a person more likely to develop salivary gland cancer. Salivary gland cancer is uncommon, and there is no widely recommended screening schedule for this cancer. CT scanning or MRI is useful for determining the extent of large tumors, for evaluating extraglandular extension, for determining the actual depth of parotid tumors, and for discovering other tumors in one gland or in the controlateral gland. Fine-needle aspiration biopsy (FNAB is a valuable diagnostic adjunct in evaluation of head and neck masses but its role in evaluation of salivary gland tumors is controversial. There are also discussed some histologic findings about mucoepidermoid carcinoma, adenoid cystic carcinoma, acinic cell carcinoma, carcinoma ex-pleomorphic adenoma, squamous cell carcinoma and adenocarcinoma developed in salivary glands. Carefully planned and executed surgical excision is the primary treatment for all malignant tumors of the salivary glands. The principles of surgery vary with the site of origin. The extent of surgery is based on the size of the tumor, local extension and neck metastases. Staging of malignant salivary gland tumors is important for predicting prognosis and for accurate comparison of treatment results.

  9. Tumores de glándulas salivales: Nuestra experiencia

    Directory of Open Access Journals (Sweden)

    Enrique Pérez Abreus

    2000-08-01

    Full Text Available Se realiza una investigación aplicada descriptiva longitudinal con todos los pacientes portadores de tumores de glándulas salivales que necesitaron tratamiento quirúrgico en el Servicio de Cirugía Maxilofacial del Hospital Universitario Clinicoquirúrgico "Dr. Gustavo Aldereguía" de Cienfuegos, durante el período de enero de 1990 a diciembre de 1999. Se observó un predominio del sexo femenino, así como del grupo etario de mayores de 60. La glándula más afectada fue la parótida, dentro de los adenomas, el pleomorfo fue el de mayor frecuencia, mientras que el carcinoma adenoideo quístico lo fue en el grupo de los carcinomas. La cirugía fue la principal arma terapéutica, seguida de la combinación quirúrgicaradiante. Además se analizan algunos esquemas de quimioterapia.An applied descriptive and longitudinal investigation was made with all the patients carriers of salivary gland tumors that needed surgical treatment at the Maxillofacial Surgery Service of "Dr. Gustavo Aldereguía" Clinical and Surgical Teaching Hospital, in Cienfuegos, from January, 1990, to December, 1999. It was observed a predominance of females as well as of the age group over 60. The parotid gland was the most affected, whereas the pleomorphic salivary adenoma was the commonest. The adenoid cystic carcinoma was the most frequent in the group of carcinomas. Surgery was the main treatment used, followed by the surgical-radiant combination. Some drug therapy schemes were also analyzed.

  10. Carcinoma of the middle ear and external auditory canal

    International Nuclear Information System (INIS)

    Thirty-one patients with malignant tumors of the middle ear and external auditory canal (EAC) were observed at the University of Virginia Hospital from 1956 through 1980. Of 27 patients with carcinoma, 21 had squamous cell carcinoma, 4 had basal cell carcinoma and 2 had adenoid cystic carcinoma. The 27 patients with carcinoma are reviewed with regard to clinical presentation, treatment modality, results and complications. The majority (67%) of patients had a history of chronic ear drainage, 22% had a previous mastoidectomy or polypectomy and 7% had an associated cholesteatoma. Eighty percent of patients with carcinoma limited to EAC were alive and well at 5 years, compared to 43% of patients with involvement of the middle ear. Fifty-six percent of patients without invasion of the petrous bone were alive at 5 years compared to only 20% of patients with petrous bone involvement. The data strongly suggest that survival depends on the extent of disease. The corrected disease free 5 year survival rates were 14% for patients who had surgery alone and 50% for those who had surgery and radiotherapy. Of the three patients with advanced disease who received radiotherapy alone, none survived five years

  11. 18F FPPRGD2 PET/CT or PET/MRI in Predicting Early Response in Patients With Cancer Receiving Anti-Angiogenesis Therapy

    Science.gov (United States)

    2014-10-02

    Adult Giant Cell Glioblastoma; Adult Glioblastoma; Adult Gliosarcoma; Male Breast Cancer; Metastatic Squamous Neck Cancer With Occult Primary Squamous Cell Carcinoma; Recurrent Adenoid Cystic Carcinoma of the Oral Cavity; Recurrent Adult Brain Tumor; Recurrent Basal Cell Carcinoma of the Lip; Recurrent Breast Cancer; Recurrent Colon Cancer; Recurrent Esthesioneuroblastoma of the Paranasal Sinus and Nasal Cavity; Recurrent Hypopharyngeal Cancer; Recurrent Inverted Papilloma of the Paranasal Sinus and Nasal Cavity; Recurrent Laryngeal Cancer; Recurrent Lip and Oral Cavity Cancer; Recurrent Lymphoepithelioma of the Nasopharynx; Recurrent Lymphoepithelioma of the Oropharynx; Recurrent Metastatic Squamous Neck Cancer With Occult Primary; Recurrent Midline Lethal Granuloma of the Paranasal Sinus and Nasal Cavity; Recurrent Mucoepidermoid Carcinoma of the Oral Cavity; Recurrent Nasopharyngeal Cancer; Recurrent Non-small Cell Lung Cancer; Recurrent Oropharyngeal Cancer; Recurrent Pancreatic Cancer; Recurrent Paranasal Sinus and Nasal Cavity Cancer; Recurrent Rectal Cancer; Recurrent Renal Cell Cancer; Recurrent Salivary Gland Cancer; Stage IIIA Breast Cancer; Stage IIIA Non-small Cell Lung Cancer; Stage IIIB Breast Cancer; Stage IIIB Non-small Cell Lung Cancer; Stage IIIC Breast Cancer; Stage IV Breast Cancer; Stage IV Non-small Cell Lung Cancer; Stage IV Pancreatic Cancer; Stage IV Renal Cell Cancer; Stage IVA Colon Cancer; Stage IVA Rectal Cancer; Stage IVA Salivary Gland Cancer; Stage IVB Colon Cancer; Stage IVB Salivary Gland Cancer; Stage IVC Salivary Gland Cancer; Tongue Cancer; Unspecified Adult Solid Tumor, Protocol Specific

  12. CT and US findings of the renal metastases

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Seung Hyup [Seoul National University College of Medicine, Seoul (Korea, Republic of)

    1995-02-15

    To evaluate imaging characteristics of metastatic renal tumors in CT and US. Renal metastases were diagnosed in 25 patients by surgery (n = 2), US-guided biopsy (n = 15), or follow-up CT (n = 8). The primary tumors metastasized to kidney were lung cancer (n = 11), adenoid cystic carcinoma (n = 3), stomach cancer (n = 2), and choriocarcinoma (n = 2). Twelve cases involved one kidney and 13 involved both kidneys. CT was performed in all 25 patients while US was done in 14. We analysed CT findings in respect to number, size, shape, exophytic degree, margin, and degree and homogeneity of the contrast enhancement of the lesion; US findings in regand to echogenicity and homogeneity of the lesion. The average number of the lesions per patient seen on CT was three; average diameter of the lesion was 3.6 cm; and 75% (57/76) of all tumors had exophytic degree of 0%. The characteristic CT findings of metastatic renal tumors were round shape (52/76), ill-defined margin (54/76), and poor (76/76) and inhomogeneous (45/76) contrast enhancement. The echogenicity of the tumors were homogeneous (11/18) and isoechoic (10/18) on US. Metastatic renal tumors had a tendency of multiple, small, ill-marginated, and less-exophytic nature on CT, and homogeneous, isoechoic appearance on US. The familiarity with the constellation of CT and US findings of renal metastasis described may be helpful in making a correct diagnosis.

  13. The Rare Cancer Network: achievements from 1993 to 2012

    Directory of Open Access Journals (Sweden)

    Kenneth Chang

    2012-06-01

    Full Text Available The Rare Cancer Network (RCN, founded in 1993, performs research involving rare tumors that are not common enough to be the focus of prospective study. Over 55 studies have either been completed or are in progress. The aim of the paper is to present an overview of the 30 studies done through the RCN to date, organized by disease site. Five studies focus on breast pathology, including sarcoma, lymphoma, phyllodes tumor, adenoid cystic carcinoma, and ductal carcinoma in situ in young women. Three studies on prostate cancer address prostatic small cell carcinoma and adenocarcinoma of young and elderly patients. Six studies on head and neck cancers include orbital and intraocular lymphoma, mucosal melanoma, pediatric nasopharyngeal carcinoma, olfactory neuroblastoma, and mucosa-associated lymphoid tissue lymphoma of the salivary glands. There were 4 central nervous system studies on patients with cerebellar glioblastoma multiforme, atypical and malignant meningioma, spinal epidural lymphoma and myxopapillary ependymoma. Outside of these disease sites, there is a wide variety of other studies on tumors ranging from uterine leiomyosarcoma to giant cell tumors of the bone. The studies done by the RCN represent a wide range of rare pathologies that were previously only studied in small series or case reports. With further growth of the RCN and collaboration between members our ability to analyze rare tumors will increase and result in better understanding of their behavior and ultimately help direct research that may improve patient outcomes.

  14. Solitary metastatic cancer to the thyroid: a report of five cases with fine-needle aspiration cytology

    Directory of Open Access Journals (Sweden)

    Batoroev Yuri

    2007-01-01

    Full Text Available Abstract Three men and 2 women with ages ranging from 37 to 70 years, clinically and histologically confirmed solitary, palpable metastatic cancers to the thyroid (SMCT and preoperative cytologic investigation of their thyroid lesions by fine-needle aspiration (FNA, were reviewed. Four patients were known to have a solid cancer treated by radical surgery 1 to 4 years prior [1 bronchogenic squamous cell carcinoma, 1 parotid adenoid cystic carcinoma, 1 renal cell carcinoma (RCC and 1 cutaneous melanoma], and 1 patient had no past history of cancer. Direct smears prepared from the patients' thyroid FNAs were fixed in 95% ethanol and stained with the Papanicolaou method. In 3 cases, immunostaining of the aspirated tumor cells with thyroglobulin antibody was performed, and in 1 case an aspiration smear was stained with commercial HMB-45 antibody. A correct cytodiagnosis of metastatic cancer to the thyroid was made in all 5 cases. In 1 patient the thyroid FNA revealed a metastatic RCC that led to the discovery of a clinically occult RCC. All 5 patients died of metastatic disease 27 to 40 months after surgical resection of their SMCTs.

  15. Tumores malignos da cavidade nasal: avaliação por tomografia computadorizada Malignant tumors of nasal cavity: computed tomography evaluation

    Directory of Open Access Journals (Sweden)

    Vinicius França de Mendonça

    2005-06-01

    Full Text Available OBJETIVO: Analisar os aspectos tomográficos dos tumores malignos da cavidade nasal. MATERIAIS E MÉTODOS: Foram estudados 18 pacientes - dez homens e oito mulheres - com tumor da cavidade nasal, os quais realizaram tomografia computadorizada da face. RESULTADOS: Dos tumores, seis eram casos de carcinoma epidermóide, três melanomas, dois carcinomas adenóides císticos, um adenocarcinoma polimórfico de baixo grau, um carcinoma indiferenciado, um carcinoma neuroendócrino, um linfoma não-Hodgkin, um rabdomiossarcoma alveolar, um sarcoma fusocelular grau II e um estesioneuroblastoma. As lesões foram mais freqüentes (p > 0,05 no lado esquerdo e no andar médio. CONCLUSÃO: Os carcinomas epidermóides apresentam grau de destruição correspondente ao seu volume, semelhante aos tumores epidermóides de outros sítios. O septo nasal foi acometido de maneira diferente, de acordo com os tipos histológicos.OBJECTIVE: To review the computed tomography findings in patients with nasal cavity tumors. MATERIALS AND METHODS: Eighteen patients - ten male and eight female - with nasal cavity tumors were studied using computed tomography. RESULTS: Histological types of the tumors included six epidermoid carcinoma, three malignant melanoma, two adenoid cystic carcinoma, and one case of each of the following: adenocarcinoma, undifferentiated carcinoma, neuroendocrine carcinoma, non-Hodgkin lymphoma, rhabdomyosarcoma, fusiform cell sarcoma, and stesioneuroblastoma. The lesions were more frequent on the left side and middle level of the nasal cavity (p > 0.05. CONCLUSION: Epidermoid carcimomas showed a close relationship between the lesion volume and the degree of destruction of adjacent structures. Septum involvement was different depending on the histological type of the lesion.

  16. Differential diagnosis of pediatric tumors of the nasal cavity and paranasal sinuses: a 45-year multi-institutional review.

    Science.gov (United States)

    Holsinger, F Christopher; Hafemeister, Adam C; Hicks, M John; Sulek, Marcelle; Huh, Winston W; Friedman, Ellen M

    2010-11-01

    We conducted a retrospective case-series review to identify the various diagnoses of neoplasms of the nasal cavity and paranasal sinuses in a pediatric population. Our study group was made up of 54 children-23 boys and 31 girls, aged 8 months to 16 years (mean: 9 yr). All patients had been diagnosed with a tumor of the nasal cavity or paranasal sinuses between Jan. 1, 1955, and Dec. 31, 1999, at one of four university-based, tertiary care referral centers. We compiled data on tumoral characteristics (location, size, and histopathology), morbidity and mortality, and rates of recurrence. Lesions included adnexal neoplasm, ameloblastic fibro-odontoma, basal cell carcinoma, benign fibrous histiocytoma, blue nevus, chondrosarcoma, compound nevus, epithelioma adenoides cysticum, esthesioneuroblastoma, Ewing sarcoma, fibrosarcoma, giant cell granuloma, granulocytic sarcoma, hemangioma, hemangiopericytoma, Langerhans cell histiocytosis, lymphangioma, lymphoma, melanoma, neuroblastoma, neurofibroma, ossifying osteofibroma, osteochondroma, osteosarcoma, port wine stain, rhabdomyosarcoma, Spitz nevus, and xanthogranuloma. To the best of our knowledge, this is the largest such study of its kind to date. We believe that the large size of this study and the data on disease incidence will allow clinicians to be better informed of the differential diagnosis of neoplasms of the nasal cavity and paranasal sinuses in the pediatric population. PMID:21086277

  17. Local Recurrence at the Bronchial Stump Site of Post-Operative Non-Small Cell Lung Cancer Patients: Comparison of CT Findings and Bronchoscopy

    International Nuclear Information System (INIS)

    To compare computed tomography (CT) images and bronchoscopic findings of local tumor recurrence at the bronchial stump site in post-operative non-small cell lung cancer (NSCLC) patients. A retrospective study was conducted to review the CT images of 9 lung cancer cases that recurred at the bronchial stump site on 576 resected primary non-small cell lung cancers over a 9-year period. The CT images of the bronchial stump site recurrence were classified as: bronchial wall thickening, nodular or endobronchial polypoid lesion, multiplicity, and enhancement patterns. We classified the bronchoscopic findings based on the revised classification by the Japan Lung Cancer Society. The histologic types of the 9 cases of lung cancer that recurred, included 7 squamous cell carcinomas, 1 adenocarcinoma, and 1 adenoid cystic carcinoma. The CT findings included bronchial wall thickening with nodules (n = 6) and endobronchial polypoid nodules (n = 3) with heterogeneous enhancement. The CT findings were further classified as nodular infiltrating type (n = 5), polypoid type (n = 3) and superficial infiltrating type (n = 1) on bronchoscopy. Both a bronchoscopy and CT can be used as a complementary or alternative tool in evaluating bronchial stump site recurrences

  18. Cancer of the nasal cavity and paranasal sinuses. A clinico-pathological study of 277 patients

    International Nuclear Information System (INIS)

    In the period 1963-1991, a total of 277 consecutive patients with malignant tumours of the nasal cavity and paranasal sinuses were treated at Aarhus University Hospital. The major histological types included squamous cell carcinoma (46%), lymphoma (14%), adenocarcinoma (13%), and malignant melanoma (9%). Kaplan-Meier estimates of 5-year corrected survival (death from cancer) showed the best prognosis for adenoid cystic carcinoma (87%), adenocarcinoma (65%) and lymphoma (56%), and the poorest prognosis for undifferentiated carcinoma (17%) and malignant melanoma (24%). The 5-year corrected survival for squamous cell carcinoma was 35%. Of the 180 patients with treatment failure, the vast majority occurred locally (n=166); a minor proportion was regional (n=23) or distant (n=30). For the 195 patients with carcinoma, the following parameters were of statistical prognostic significance (5-year corrected survival): Histological differentiation (moderate-well 65% vs. poor 22%), primary T-site (nasal cavity 56% vs. maxillary antrum 39% vs. other sinuses 24%), tumour stage (T2 68% vs. T3 37% vs. T4 29%), nodal stage (N0 48% vs. N1-3 21%), treatment (radiotherapy+surgery 56% vs. radiation alone 35%). (orig.)

  19. Cancer of the nasal cavity and paranasal sinuses. A clinico-pathological study of 277 patients

    DEFF Research Database (Denmark)

    Harbo, G; Grau, Cai

    1997-01-01

    In the period 1963-1991, a total of 277 consecutive patients with malignant tumours of the nasal cavity and paranasal sinuses were treated at Aarhus University Hospital. The major histological types included squamous cell carcinoma (46%), lymphoma (14%), adenocarcinoma (13%), and malignant melanoma (9%). Kaplan-Meier estimates of 5-year corrected survival (death from cancer) showed the best prognosis for adenoid cystic carcinoma (87%), adenocarcinoma (65%) and lymphoma (56%), and the poorest prognosis for undifferentiated carcinoma (17%) and malignant melanoma (24%). The 5-year corrected survival for squamous cell carcinoma was 35%. Of the 180 patients with treatment failure, the vast majority occurred locally (n = 166); a minor proportion was regional (n = 23) or distant (n = 30). For the 195 patients with carcinoma, the following parameters were of statistical prognostic significance (5-year corrected survival): histological differentiation (moderate-well 65% vs. poor 22%), primary T-site (nasal cavity 56% vs. maxillary antrum 39% vs. other sinuses 24%), tumour stage (T2 68% vs. T3 37% vs. T4 29%), nodal stage (N0 48% vs. N1-3 21%), treatment (radiotherapy + surgery 56% vs. radiation alone 35%).

  20. Adenotonsillar hypertrophy as a risk factor of dentofacial abnormality in Korean children.

    Science.gov (United States)

    Kim, Dong-Kyu; Rhee, Chae Seo; Yun, Pil-Young; Kim, Jeong-Whun

    2014-12-10

    No studies for the role of adenotonsillar hypertrophy in development of dentofacial abnormalities have been performed in Asian pediatric population. Thus, we aimed to investigate the relationship between adenotonsillar hypertrophy and dentofacial abnormalities in Korean children. The present study included consecutive children who visited a pediatric clinic for sleep-disordered breathing due to habitual mouth breathing, snoring or sleep apnea. Their palatine tonsils and adenoids were graded by oropharyngeal endoscopy and lateral cephalometry. Anterior open bite, posterior crossbite, and Angle's class malocclusions were evaluated for dentofacial abnormality. The receiver-operating characteristic curve analysis was used to identify age cutoffs to predict dentofacial abnormality. A total of 1,083 children were included. The presence of adenotonsillar hypertrophy was significantly correlated with the prevalence of dentofacial abnormality [adjusted odds ratio = 4.587, 95 % CI (2.747-7.658)] after adjusting age, sex, body mass index, allergy, and Korean version of obstructive sleep apnea-18 score. The cutoff age associated with dentofacial abnormality was 5.5 years (sensitivity = 75.5 %, specificity = 67 %) in the children with adenotonsillar hypertrophy and 6.5 years (sensitivity = 70.6 %, specificity = 57 %) in those without adenotonsillar hypertrophy. In conclusion, adenotonsillar hypertrophy may be a risk factor for dentofacial abnormalities in Korean children and early surgical intervention could be considered with regards to dentofacial abnormality. PMID:25490975

  1. Disturbance of intracardiac hemodynamics in children with chronic rheumatic cardiac disease

    Directory of Open Access Journals (Sweden)

    Kondratiev V.A.

    2013-12-01

    Full Text Available By means of Doppler echocardiography there have been studied disturbances of intracardiac hemodynamics in 44 children aged 8-17 years with chronic rheumatic cardiac disease and developed mitral aortal and combined heart defects, as well as in chronic rheumatic cardiac disease without developed valvar defect. Differential approach has been defined to administration of inhibitors of angiotensin-converting factor in rheumatic heart defects: developed insufficiency of mitral and/or aortal valves II-III stage leads to remodeling of the left heart portions with developing chronic insufficiency of blood circulation, being an index for prolonged, not less than a year usage of the angiotensin-converting factor. In the presence of isolated mitral regurgitation, I stage in children with chronic rheumatic cardiac disease usage of the angiotensin-converting factor may be cancelled due to insignificant disturbances of valvar hemodynamics and a small risk of developing blood circulation insufficiency. Timely sanation of chronic infection foci in nasopharynx (conservative and surgical treatment of chronic tonsillitis, adenoid vegetations, therapy of hemolytic streptococcus presence decreases risk of developing rheumatic heart defect in children suffered acute rheumatic fever.

  2. Salso-sulphide thermal water in the prevention of recurrent respiratory infections in children.

    Science.gov (United States)

    Varricchio, A; Giuliano, M; Capasso, M; Del Gaizo, D; Ascione, E; De Lucia, A; Avvisati, F; Capuano, F; De Rosa, G; Di Mauro, F; Ciprandi, G

    2013-01-01

    Recurrent respiratory infections (RRI) represent a social problem for both the pharmaco-economic impact and the burden on the family. Thermal water is popularly well accepted. However, there is no scientific evidence of its preventive activity on recurrent respiratory tract infections (RRI). Therefore, the purpose of this study was to evaluate the effects of Agnano thermal water nasal irrigation on RRI prevention in children.A total of 107 children (70 males, mean age 4.5 plus minus1.2 years) with RRI were enrolled in the study. At baseline, children were randomly assigned to the treatment with: A) inhaled crenotherapy with salso-sulphide water or B) isotonic saline (NaCl 0.9 percent). Inhaled therapy was performed using nasal washing by Rino-jet (ASEMA srl, Milan, Italy) b.i.d. for 12 days. Nasal washing lasted 2 minutes per nostril. Immediately before washing, children inhaled 1 l of water by stream inhalation per 2 minutes. Crenotherapy was capable of significantly reducing: the number of respiratory infections, nasal symptoms, neutrophil and bacteria count, turbinate and adenoidal hypertrophy, presence of biofilm, and blockage of ostiomeatal complex (OCM). In conclusion, this study provides the first evidence that Agnano crenotherapy may be capable of preventing RRI in children as it exerts some positive effects, such as reduction of nasal obstruction, OCM blockage, biofilm, and inflammatory events. PMID:24355229

  3. Tricoepitelioma múltiple / Multiple tricoephitelioma

    Scientific Electronic Library Online (English)

    C., Gutiérrez Gómez; R., Martínez Wagner; F.J., López Mendoza; V.M., Rosales Galindo; E., Márquez Gutiérrez.

    2012-06-01

    Full Text Available SciELO Spain | Language: Spanish Abstract in spanish El tricoepitelioma, descrito por Brooke en 1892 y también llamado epitelioma adenoideo quístico, es una genodermatosis autosómica dominante originada en el complejo pilosebáceo. Existen dos formas clínicas: la solitaria y la múltiple. Algunos autores recomiendan no tratarlo; sin embargo las lesiones [...] múltiples tienden a deformar la anatomía y la resección parcial presenta recidivas así como cicatrices excesivas y en algunos casos tienen un comportamiento agresivo. Presentamos un caso clínico de tricoepitelioma con deformidad severa de la cara en el que se realizó tratamiento radical con restitución de unidades estéticas mediante colgajos locales. Consideramos que los casos agresivos o deformantes deben ser tratados de forma radical, eliminando todo el espesor de la piel para obtener resultados satisfactorios. Abstract in english Trichoepithelioma, first described by Brooke in 1892, also known as cystic adenoid epithelioma, is a dominantly inherited genodermatosis originated in the follicle bulb. There are two clinical forms, solitary and multiple. Some authors advocate not to treat them, but multiple trichoepithelioma prese [...] nts a significant cosmetic problem and partial resection can lead to recurrence and excessive scarring, some cases with an aggressive behavior. We present a clinical case of multiple tricoepithelioma with severe deformity of the face in which we realized radical resection with restitution of anatomical units by local flaps. We consider that the multiple cases should be excised with total skin to avoid recurrence and obtain acceptable results.

  4. Tricoepitelioma múltiple Multiple tricoephitelioma

    Directory of Open Access Journals (Sweden)

    C. Gutiérrez Gómez

    2012-06-01

    Full Text Available El tricoepitelioma, descrito por Brooke en 1892 y también llamado epitelioma adenoideo quístico, es una genodermatosis autosómica dominante originada en el complejo pilosebáceo. Existen dos formas clínicas: la solitaria y la múltiple. Algunos autores recomiendan no tratarlo; sin embargo las lesiones múltiples tienden a deformar la anatomía y la resección parcial presenta recidivas así como cicatrices excesivas y en algunos casos tienen un comportamiento agresivo. Presentamos un caso clínico de tricoepitelioma con deformidad severa de la cara en el que se realizó tratamiento radical con restitución de unidades estéticas mediante colgajos locales. Consideramos que los casos agresivos o deformantes deben ser tratados de forma radical, eliminando todo el espesor de la piel para obtener resultados satisfactorios.Trichoepithelioma, first described by Brooke in 1892, also known as cystic adenoid epithelioma, is a dominantly inherited genodermatosis originated in the follicle bulb. There are two clinical forms, solitary and multiple. Some authors advocate not to treat them, but multiple trichoepithelioma presents a significant cosmetic problem and partial resection can lead to recurrence and excessive scarring, some cases with an aggressive behavior. We present a clinical case of multiple tricoepithelioma with severe deformity of the face in which we realized radical resection with restitution of anatomical units by local flaps. We consider that the multiple cases should be excised with total skin to avoid recurrence and obtain acceptable results.

  5. Cisplatin-induced Casepase-3 activation in different tumor cells

    Science.gov (United States)

    Shi, Hua; Li, Xiao; Su, Ting; Zhang, Yu-Hai

    2008-12-01

    Apoptosis plays an essential role in normal organism development which is one of the main types of programmed cell death to help tissues maintain homeostasis. Defective apoptosis can result in cell accumulation and therefore effects on tumor pathogenesis, progression and therapy resistance. A family of proteins, known as caspases, is typically activated in the early stages of apoptosis. Therefore, studying the kinetics of activation of caspases induced by antitumor drugs can contribute to antitumor drug discovery and explanation of the molecular mechanisms. This paper detected the Caspase-3 activity induced by cisplatin in human adenoid cystic carcinoma cell line (ACC-M), human hepatocellular liver carcinoma cell line (HepG2) and human epithelial carcinoma cell line (Hela) with stably expressing ECFP-DEVDDsRed (CD3) probe, a fluorescent probe consisting of Enhanced Cyan Fluorescent Protein (ECFP), red fluorescent protein (DsRed) and a linker with a recognition site of Caspase-3, by using the capillary electrophoresis (CE) and fluorescence resonance energy transfer (FRET) imaging system. Under the same concentration of cisplatin, ACC-M cells responded the most rapidly, and then HepG2 cells and Hela cells, respectively, in the early 30 hours. Later, HepG2 cells represented acceleration in the Caspase-3 activation speed and reached full activation the earliest comparing to other two cell types. The results demonstrated that ACC-M cell is more sensitive than the other two cell types under the treatment of cisplatin.

  6. Driver mutations of cancer epigenomes.

    Science.gov (United States)

    Roy, David M; Walsh, Logan A; Chan, Timothy A

    2014-04-01

    Epigenetic alterations are associated with all aspects of cancer, from tumor initiation to cancer progression and metastasis. It is now well understood that both losses and gains of DNA methylation as well as altered chromatin organization contribute significantly to cancer-associated phenotypes. More recently, new sequencing technologies have allowed the identification of driver mutations in epigenetic regulators, providing a mechanistic link between the cancer epigenome and genetic alterations. Oncogenic activating mutations are now known to occur in a number of epigenetic modifiers (i.e. IDH1/2, EZH2, DNMT3A), pinpointing epigenetic pathways that are involved in tumorigenesis. Similarly, investigations into the role of inactivating mutations in chromatin modifiers (i.e. KDM6A, CREBBP/EP300, SMARCB1) implicate many of these genes as tumor suppressors. Intriguingly, a number of neoplasms are defined by a plethora of mutations in epigenetic regulators, including renal, bladder, and adenoid cystic carcinomas. Particularly striking is the discovery of frequent histone H3.3 mutations in pediatric glioma, a particularly aggressive neoplasm that has long remained poorly understood. Cancer epigenetics is a relatively new, promising frontier with much potential for improving cancer outcomes. Already, therapies such as 5-azacytidine and decitabine have proven that targeting epigenetic alterations in cancer can lead to tangible benefits. Understanding how genetic alterations give rise to the cancer epigenome will offer new possibilities for developing better prognostic and therapeutic strategies. PMID:24622842

  7. Paediatric rhinitis : position paper of the European Academy of Allergy and Clinical Immunology

    DEFF Research Database (Denmark)

    Roberts, G; Xatzipsalti, M

    2013-01-01

    Rhinitis is a common problem in childhood and adolescence and impacts negatively on physical, social and psychological well-being. This position paper, prepared by the European Academy of Allergy and Clinical Immunology Taskforce on Rhinitis in Children, aims to provide evidence-based recommendations for the diagnosis and therapy of paediatric rhinitis. Rhinitis is characterized by at least two nasal symptoms: rhinorrhoea, blockage, sneezing or itching. It is classified as allergic rhinitis, infectious rhinitis and nonallergic, noninfectious rhinitis. Similar symptoms may occur with other conditions such as adenoidal hypertrophy, septal deviation and nasal polyps. Examination by anterior rhinoscopy and allergy tests may help to substantiate a diagnosis of allergic rhinitis. Avoidance of relevant allergens may be helpful for allergic rhinitis (AR). Oral and intranasal antihistamines and nasal corticosteroids are both appropriate for first-line AR treatment although the latter are more effective. Once-daily forms of corticosteroids are preferred given their improved safety profile. Potentially useful add-on therapies for AR include oral leukotriene receptor antagonists, short bursts of a nasal decongestant, saline douches and nasal anticholinergics. Allergen-specific immunotherapy is helpful in IgE-mediated AR and may prevent the progression of allergic disease. There are still a number of areas that need to be clarified in the management of rhinitis in children and adolescents.

  8. Salivary gland cancer stem cells.

    Science.gov (United States)

    Adams, April; Warner, Kristy; Nör, Jacques E

    2013-09-01

    Emerging evidence suggests the existence of a tumorigenic population of cancer cells that demonstrate stem cell-like properties such as self-renewal and multipotency. These cells, termed cancer stem cells (CSC), are able to both initiate and maintain tumor formation and progression. Studies have shown that CSC are resistant to traditional chemotherapy treatments preventing complete eradication of the tumor cell population. Following treatment, CSC are able to re-initiate tumor growth leading to patient relapse. Salivary gland cancers are relatively rare but constitute a highly significant public health issue due to the lack of effective treatments. In particular, patients with mucoepidermoid carcinoma or adenoid cystic carcinoma, the two most common salivary malignancies, have low long-term survival rates due to the lack of response to current therapies. Considering the role of CSC in resistance to therapy in other tumor types, it is possible that this unique sub-population of cells is involved in resistance of salivary gland tumors to treatment. Characterization of CSC can lead to better understanding of the pathobiology of salivary gland malignancies as well as to the development of more effective therapies. Here, we make a brief overview of the state-of-the-science in salivary gland cancer, and discuss possible implications of the cancer stem cell hypothesis to the treatment of salivary gland malignancies. PMID:23810400

  9. [Update of clinical programs using hadrontherapy 2008-2012].

    Science.gov (United States)

    Habrand, J-L; Datchary, J; Alapetite, C; Bolle, S; Calugaru, V; Feuvret, L; Helfre, S; Stefan, D; Delacroix, S; Demarzi, L; Dendale, R

    2013-10-01

    Hadrontherapy, a type of radiation therapy dealing with heavy charged particles, has become for the past decade one of the most sophisticated and attractive approach in the management of cancer. This is related with major technological innovations that have made available, at a relatively cheap cost, compact proton accelerators equipped with rotational gantries. The implementation of pencil beam scanning should also make treatment planning and delivery much easier and faster than conventional approaches. Until now, approximately 100,000 patients have been treated with protons worldwide. Due to more complex technological and biological challenges, light ion therapy - mainly carbon ions - has developed at a lower pace, except in Japan where most of the 15,000 treated patients have been enrolled. Current indications for protons include firstly, locally aggressive tumours non or incompletely resected, that are located close to critical normal structures: ocular melanomas, skull base and spinal canal low grade sarcomas, selected ENT carcinomas (like adenoid cystic); secondly, improvement of tolerance to radiations: delayed, mainly in paediatric malignancies, due to the exquisite sensitivity of organs under development (including to carcinogenesis); immediate, on bone marrow, mucosae… mainly in concomitant radiation-chemotherapy interactions (tested in esophagus, and lung). Most promising indications for carbon ions include inoperable highly radioresistant primaries, such as mucosal melanomas, high grade bone and soft part sarcomas, and pancreatic carcinomas. Altered fractionations are also of interests that could translate in clinical and economical benefits. Controversies have risen whether more common indications, like prostate, should also be explored. PMID:24007956

  10. The Study of the Malignant Tumors of the Maxillary Sinus by Computed Tomography

    International Nuclear Information System (INIS)

    CT findings of proven 25 malignant tumors of the maxillary sinus were retrospectively analyzed to be of help in the diagnosis and treatment. The results were as follow: 1. Average age was 54 years old, and eighteen were males and seven were females with a ratio of 2.6:1. 2. The most common histopathologic feature was squamous cell carcinoma (19 cases) and others were two cases of adenoid cystic carcinoma, one case of malignant fibrous histiocytoma, mucoepidermoid tumor, histiocytic lymphoma, unidentified malignant tumor. 3. CT findings were sinus opacification (4%), soft tissue mass (92%), low densities within soft tissue mass (44%), air densities within soft tissue mass (24%), osteosclerosis (4%), bone destruction (92%), bone displacement (32%), fat plane obliteration(76%). 4. CT in the malignant maxillary sinus tumors approved the value in evaluation of tumor extension to nasal cavity, ethmoid sinus, orbit, infratemporal fossa, pterygopalatine fossa, pterygoid fossa, pterygoid muscle, cheek skin and intracranial cavity. 5. Twenty four cases (96%) were stage III, stage IV according to AJCC TNM classification. 6. Bone findings were destruction, displacement, sclerosis and most frequent site of bone destruction was the medial wall of the antrum (92%). 7. Tumor growth pattern showed destructive pattern in 18 cases (72%), and squamous cell carcinoma showed destructive pattern. (p<0.05).

  11. Magnetic resonance imaging assessment of tumorous lesions in the floor of the mouth. Case reports and review of the literature

    International Nuclear Information System (INIS)

    Magnetic resonance (MR) imaging may provide some information as to the extent and tissue characteristics of a cancerous mass, but the imaging features of lesions in the floor of the mouth have not been sufficiently clarified. MR imaging features of tumescent lesions in this region were characterized, and the differential diagnoses are discussed. MR images of 12 patients with tumescent lesions in the floor of the mouth (three patients with squamous cell carcinoma, two with adenoid cystic carcinoma, one with hemangioma, one with schwannoma, one with lipoma, and four with ranula) were reviewed. The literature on the imaging features of tumescent disease in the floor of the mouth was searched using the Medline database. Six types of tumescent lesions in the floor of the mouth are presented. The differential diagnosis through a review of the references is discussed. Malignant tumors were demonstrated as ill-defined masses. MR images were good at showing the internal structures, such as fluid, hemorrhage, fat, nerves, calculus (phlebolith), cholesterol, and keratin, as different signal intensities. Therefore, MR images gave clues for the differential diagnosis. MR images presented the distinctive features or the extent of the lesions and were therefore considered useful for a more accurate diagnosis prior to treatment. (author)

  12. Prevalence of salivary glands lesions from histopathologic diagnosis of Experimental Pathology Laboratory of PUCPR in the period of 1999-2008

    Directory of Open Access Journals (Sweden)

    Alexandre BETTIO

    2009-09-01

    Full Text Available Introduction: Lesions that affect salivary glands are a group of clinic entities ranging from local pathological alterations to the manifestation of systemic diseases. Objective: The aim of this study was to observe the prevalence of cases of lesions regarding salivary glands in patients of dental clinic of the Pontifícia Universidade Católica do Paraná (PUCPR. Material and methods: A total of 1990 histopathologic reports was analyzed in data of Experimental Pathology Laboratory of the Pontifícia Universidade Católica do Paraná, in the period of 1999 to 2008. Seventy-three cases of salivary glands diseases were analyzed, according to sex, age and histopathologic diagnosis. Results: Mucocele was the most prevalent lesion, with 58 cases (2.9%. Others diseases were diagnosed, such as: pleomorphic adenoma (0.3%, cystic adenoid carcinoma (0.1%, sialoadenitis (0.1%, mucoepidermoid carcinoma (0.05%, Sjögren’s syndrome (0.05%, ranula (0.05% and adenomatoid hyperplasia (0.05%. No predilection for sex was observed, but the majority of diseases occurred principally during the three first life decades. Conclusion: These findings reinforce that the occurrence oflesions associated to the salivary glands is low when compared to others oral diseases. The more common pathological entities that affect salivary glands are associated to traumatic agents and affect adult male young patients.

  13. Incidence of Actinomycosis in Tonsillectomized Patients: Histopathologic Data for 115 Cases and a Rare Localization of Actinomycosis in Tongue Base

    Directory of Open Access Journals (Sweden)

    Emine Elif Altunta?

    2010-08-01

    Full Text Available Objective: In this study, we aimed to investigate the detection rate of histopathologically confirmed actinomycosis in tonsillectomized cases, during a 19-year period. A case with actinomycosis in a rare localization such as the tongue root is also reported and, in this case, our diagnosis and treatment approach is overviewed with the literature.Methods: 1047 patients who underwent tonsillectomy for various reasons between January 1990 and December 2009 in the Department of Otorhinolaryngology, Faculty of Medicine, Cumhuriyet University were investigated retrospectively. The surgical materials of 115 (11% cases with suspicious macroscopic appearance of tonsillar tissue, unilateral tonsillar hypertrophy and suspected malignancy on clinical examination were evaluated histopathologically.Results: In this study, 66 (57.4% cases were male and 49 (42.6% female. A chronic granulomatous process and colonies of actinomycetes were reported pathologically in 32 (27.8% cases and a chronic inflammatory process in 83 (72.2% cases.Conclusions: Despite the medical and economic burden, all surgical specimens obtained from cases who underwent tonsillectomy and adenoidectomy should be examined histopathologically as well as specimens from patients with suspected malignancy. We think that this clinical approach will contribute not only to make an early diagnosis and to determine the frequency of tonsillar cancers that are rarely seen in childhood, but also to determine the role of actinomycosis in the etiology of chronic tonsillitis and adenoid vegetation.

  14. Does altered fractionation influence the risk of radiation-induced optic neuropathy?

    International Nuclear Information System (INIS)

    Purpose: To analyze the parameters that influence the risk of radiation-induced optic neuropathy (RION) after radiotherapy for head-and-neck tumors. Methods and Materials: Between 1964 and 2000, 273 patients with tumors of the nasopharynx, paranasal sinuses, nasal cavity, and hard palate adenoid cystic carcinomas were treated with curative intent and had radiation fields that included the optic nerves and/or chiasm. Patients were followed for at least 1 year after radiotherapy. Results: Radiation-induced optic neuropathy developed in 32 eyes of 24 patients (9%). The 5-year rates of freedom from RION according to the total dose and once- vs. twice-daily fractionation were as follows: ?63 Gy once daily, 95%; ?63 Gy twice daily, 98%; >63 Gy once daily, 78%; and >63 Gy twice daily, 91%. Multivariate analysis revealed that the total dose affected the risk of RION (p = 0.0047), with patient age (p = 0.0909), once-daily vs. twice-daily fractionation (p = 0.0684), and overall treatment time (p = 0.0972) were marginally significant. The use of adjuvant chemotherapy did not significantly influence the likelihood of developing RION. Conclusion: The likelihood of developing RION is primarily influenced by the total dose. Hyperfractionation may reduce the risk of experiencing this complication

  15. Allergic rhinitis in the child and associated comorbidities.

    Science.gov (United States)

    Sih, Tania; Mion, Olavo

    2010-02-01

    Allergic rhinitis (AR) typically presents after the second year of life, but the exact prevalence in early life is unknown. AR affects 10-30% of the population, with the greatest frequency found in children and adolescents. It appears that the prevalence has increased in the pediatric population. As the childs' immune system develops between the 1st and 4th yr of life, those with an atopic predisposition begin to express allergic disease with a clear Th(2) response to allergen exposure, resulting in symptoms. In pediatric AR, two or more seasons of pollen exposure are generally needed for sensitization, so allergy testing to seasonal allergens (trees, grasses, and weeds) should be conducted after the age of 2 or 3 years. Sensitization to perennial allergens (animals, dust mites, and cockroaches) may manifest several months after exposure. Classification of AR includes measurement of frequency and duration of symptoms. Intermittent AR is defined as symptoms for quality of life, sleep disorders, emotional problems, and impairment in activities such as work and school productivity and social functioning. AR can also be graded in severity - either mild or moderate/severe. There are comorbidities associated with AR. The chronic effects of the inflammatory process affect lungs, ears, growth, and others. AR can induce medical complications, learning problems and sleep-related complaints, such as obstructive sleep apnea syndrome and chronic and acute sinusitis, acute otitis media, serous otitis media, and aggravation of adenoidal hypertrophy and asthma. PMID:19664013

  16. A case of basal cell epitheliomas developed on chronic radiodermatitis (so-called roentgen-skin)

    International Nuclear Information System (INIS)

    A woman 63 years old had received an unknown amount of roentgen rediation from a physician for spondylitis tuberculosa of the thoracic vertebrae fifty years ago. About five years ago two small brownish black tumors appeared on her back and gradually increased. Within the past month ulcer and bleeding in these tumors. The Patient presented a chronic radiodermatitis (so-called roentgen-skin) of the interscapular space. In addition, two tumors were present in the upper and lower parts of the roentgen-skin. The upper tumor revealed adenoid basal cell epithelioma and the lower tumor was pigmented solid basal cell epithelioma. A view on the development of basal cell epitheliomas on the roentgen-skin was assumed as follows: When epidermal and adnexal cells suffer from a certain damage by X-ray, especially soft X-ray, these cells may become modulated cells which have the same functions as adult immature pluripotential cells. From these modulated cells, basal cell epitheliomas may develop. (author)

  17. Radiation to the head, neck, and upper thorax of the young and thyroid neoplasia

    International Nuclear Information System (INIS)

    It is now generally accepted that an association exists between external radiation administered to the head, neck and upper thorax of infants, children and adolescents and the subsequent development of neoplastic changes in the thyroid gland. Until recent years external radiation was frequently administered to shrink an enlarged thymus, or for the treatment of tonsillitis, adenoiditis, hearing loss, hemangioma, acne, tinea capitis and other conditions. During the course of these treatments, the thyroid gland was exposed to scattered radiation. It is stressed that the use of external radiation therapy was then accepted practice and its value was attested by many. The likelihood of adverse effects was not initially apparent, primarily because of the long periods of time between the administration of the therapy and the recognition of changes in the thyroid. The availability and effectiveness of other therapeutic measures and the growing concern about the delayed effects of radiation therapy when administered to the young for relatively benign conditions has, in recent years, largely eliminated use of this form of therapy, except in a few unusual conditions

  18. Caspase-3-independent pathways proceeding in bystander effect of HSV-tk/GCV system

    Science.gov (United States)

    Lin, Juqiang; Ma, Yan; Zeng, Shaoqun; Zhang, Zhihong

    2008-02-01

    HSV-tk/GCV system, which is the virus-directed enzyme/prodrug therapy of herpes simplex virus (HSV) thymidine kinase (tk) gene / the anti-viral reagent ganciclovir (GCV), is one of the promising approaches in the rapidly growing area of gene therapy. As gene therapy of cancer such as suicide gene therapy has entered the clinic, another therapy effect which is called 'bystander effect' was reported. Bystander effect can lead to killing of non-transduced tumor cells in the immediate vicinity of GCV-treated HSV-TK-positive cells. Now the magnitude of 'bystander effect' is an essential factor for this anti-tumor approach in vivo. However, the mechanism which HSV-tk/ACV brings "bystander effect" is poorly understood. In this study, we monitor the activation of caspase-3 in HSV-tk/GCV system by a FRET probe CD3, a FRET-based indicator for activity of caspase3, which is composed of an enhanced cyan fluorescent protein, a caspase-sensitive linker, and a red fluorescent protein from Discosoma with efficient maturation property. Through application of CD3 we have visualized the activation of caspase-3 in tk gene positive human adenoid cystic carcinoma (ACC-M) cells but not in bystander effect of HSV-tk/GCV system induced by GCV. This finding provides needed information for understanding the mechanisms by which suicide gene approaches actually kill cancer cells, and may prove to be helpful for the clinical treatment of cancers.

  19. The rare cancer network: ongoing studies and future strategy.

    Science.gov (United States)

    Ozsahin, Mahmut; Mirimanoff, René-Olivier; Thariat, Juliette; Sun, Xu Shan; Atalar, Banu; Lassen-Ramshad, Yasmin; Ugurluer, Gamze; Krishnan, Sunil; Hallemeier, Christopher; Houtte, Paul Van; Krengli, Marco; Zhang, Lan Jun; Chang, Kenneth; Funk, Ryan; Rooney, Jessica; Miller, Robert C

    2014-07-30

    The Rare Cancer Network (RCN) was formed in the early 1990's to create a global network that could pool knowledge and resources in the studies of rare malignancies whose infrequency prevented both their study with prospective clinical trials. To date, the RCN has initiated 74 studies resulting in 46 peer reviewed publications. The First International Symposium of the Rare Cancer Network took place in Nice in March of 2014. Status updates and proposals for new studies were heard for fifteen topics. Ongoing studies continue for cardiac sarcomas, thyroid cancers, glomus tumors, and adult medulloblastomas. New proposals were presented at the symposium for primary hepatic lymphoma, solitary fibrous tumors, Rosai-Dorfman disease, tumors of the ampulla of Vater, salivary gland tumors, anorectal melanoma, midline nuclear protein in testes carcinoma, pulmonary lymphoepithelioma-like carcinoma, adenoid cystic carcinoma of the trachea, osteosarcomas of the mandible, and extra-cranial hemangiopericytoma. This manuscript presents the abstracts of those proposals and updates on ongoing studies, as well a brief summary of the vision and future of the RCN. PMID:25276326

  20. The correlation between tonsil size and academic performance is not a direct one, but the results of various factors.

    Science.gov (United States)

    Kargoshaie, A A; Najafi, M; Akhlaghi, M; Khazraie, H R; Hekmatdoost, A

    2009-10-01

    Chronic upper airway obstruction most often occurs when both tonsils and adenoid are enlarged but may occur when either is enlarged. Obstructive sleep syndrome in young children has been reported to be associated with an adverse effect on learning and academic performance. The aim of this study was to evaluate the effect of relative size of the tonsil on academic performance in 4th grade school children. In 320 children, physical examination to determine the size of tonsils was performed by the otorhinolaryngologist. A questionnaire was developed to assess sleep patterns and problems, and socio-demographic data for the student participants. Furthermore, their school performance was assessed using their grade in mathematics, science, reading, spelling, and handwriting. No association between tonsil size and academic performance was found. Snoring frequency, body mass index and body weight showed a positive relation with tonsil size. There was no association between tonsil size and sleepiness during the day, sleeping habits, hyperactivity, enuresis, history of tonsillectomy in children and parental cigarette smoking and education. In conclusion, this study did not show any significant relationship between tonsil size and academic performance in 4th grade students. Further studies are recommended with a larger sample size, cognitive exams for evaluation of attention, and follow-up of the students until high school, when the discrepancy of the students' academic performance is more obvious. PMID:20162026

  1. Added value of contrast-enhanced CISS imaging in relation to conventional MR images for the evaluation of intracavernous cranial nerve lesions

    Energy Technology Data Exchange (ETDEWEB)

    Yagi, Akiko; Takahashi, Ayako; Morita, Hideo; Amanuma, Makoto; Endo, Keigo [Gunma University School of Medicine, Department of Diagnostic Radiology and Nuclear Medicine, Gunma (Japan); Sato, Noriko [National Center Hospital of Neurology and Psychiatry, Department of Radiology, Kodaira, Tokyo (Japan); Takeuchi, K. [Takasaki University of Health and Welfare, Department of Health and Welfare, Gunma (Japan)

    2010-12-15

    The normal cranial nerves (CNs) of the cavernous sinus can be clearly demonstrated using contrast-enhanced constructive interference in steady-state (CISS) magnetic resonance imaging (MRI). This study used the method to evaluate pathological CNs III, IV, V{sub 1}, V{sub 2}, and VI in cavernous sinuses affected by inflammatory and neoplastic diseases. MR images from 17 patients with diseases involving the cavernous sinuses and/or causing neuropathy in CNs III-VI were retrospectively evaluated. The patients were divided into inflammatory (n = 11) and neoplastic (n = 6) groups. We defined CNs as abnormal when they exhibited enlargement or enhancement. CNs were evaluated using both contrast-enhanced CISS and T1-weighted MRI. In the inflammatory group, abnormal CNs were identified by contrast-enhanced CISS MRI in 13 of 25 symptomatic CNs (52%) in eight patients, but in only two CNs (8%) in two patients by contrast-enhanced T1-weighted MRI. In the neoplastic group, both sequences of contrast-enhanced CISS and T1-weighted MRI detected abnormalities in the same three of eight symptomatic CNs (37.5%), i.e., the three CNs were all in the same patient with adenoid cystic carcinoma. Contrast-enhanced CISS MRI is useful for detecting CN abnormalities in inflammatory pathological conditions of the cavernous sinuses. (orig.)

  2. Paraplegia after intercostal neurolysis with phenol

    Science.gov (United States)

    Gollapalli, Lakshman; Muppuri, Rudramanaidu

    2014-01-01

    In patients with advanced stages of cancer, severe pain is commonly encountered and is very difficult to treat. It affects the quality of life of the patient and the families involved. Pain can be managed using analgesics and adjuvant therapy. However, studies have shown that at least 10%–15% of patients fail to control pain adequately and will experience severe pain. We discuss the case of a 66-year-old female with metastatic adenoid cystic carcinoma of the left submandibular gland and developed paraplegia following intercostal neurolysis with phenol. After a successful diagnostic T6 to T12 intercostal nerve block, the patient was scheduled for an intercostal neurolytic block. We injected 2 mL of 10% aqueous phenol at each level on the left from the T6 to T12 ribs. One hour after the procedure, the patient developed bilateral lower extremity weakness with difficulty moving. A physical examination showed the absence of sensation to pinpricks and vibration from T10 to S5 and an absence of anal sphincter tone and sensation. Magnetic resonance images of the thoracic and lumbar spine showed leptomeningeal metastatic disease and myelitis. We postulate that the paraplegia could be from phenol diffusing along either the spinal nerves or the paravertebral venous plexus into the subarachnoid space. This case report points to the risks involved with phenol neurolysis close to the spine, and we propose alternative methods to minimize neurological complications. PMID:25429238

  3. Numb chin syndrome: a case series of a clinical syndrome associated with malignancy

    International Nuclear Information System (INIS)

    Information regarding the appropriate work-up and outcomes in patients receiving palliative treatment for numb chin syndrome (NCS) in the setting of malignancy is sparse. This study aims to describe NCS in malignancy and evaluate the disease trajectory, significance of diagnostic modalities and outcomes with palliative treatment. A retrospective study was performed on patients presenting with NCS between March 2007 and October 2013 at the Capital Region Cancer Service, Canberra. Thirteen patients were identified who presented with numbness of the chin between March 2007 and October 2013. Seven patients had breast cancer, two had prostate cancer, two had multiple myeloma, one had medulloblastoma and one had an adenoid cystic salivary gland tumour. The mean interval from initial cancer diagnosis to development of the syndrome was 4.32 years. Twelve out of 13 patients had had prior chemotherapy with two or more lines of treatment (with a median of two lines), indicating this condition tended to present late in the course of disease in our patients. Four patients developed bilateral symptoms, and in two of these cases the metastatic lesion was in the base of the skull. Eleven out of 13 patients had positive signs on imaging. Nine out of 13 patients received palliative radiotherapy, with clinical response in eight patients. Patients with malignancy presented with NCS late in the disease trajectory, often after multiple lines of treatment. In our cohort of patients, 84% had positive imaging signs to aid diagnosis, and 77% had resolution of numbness with palliative treatment.

  4. Radiotherapy for malignant tumor of the ear

    International Nuclear Information System (INIS)

    Fifteen patients with malignant tumor of the ear were treated with radiotherapy between January 1966 and May 1993. The age ranged from 3 to 81 years with a mean age of 52, and male to female ratio was 10 to 5. Tumor sites were the external auditory canal in 12 cases and middle ear in 3 cases. There were 4 cases in T1, 8 in T2, and 3 in T3 by Stell's stage classification, and there were 13 in N0, 1 in N1 and 1 in N2, which were all M0. There were 10 squamous cell carcinomas, 3 adenoid cystic carcinomas. 1 liposarcoma and 1 rhabdomyosarcoma. Radiotherapy was administered to 12 cases postoperatively, to 3 cases definitively with a total dose of 48 Gy to 66 Gy in adult cases. The follow-up period ranged from 11 months to 15 years and 3 months (mean 8 years). The overall local control rate and the overall cumulative 5-year rate and the cause specific 5-year survival rate were 73%, 46.9% and 62.5%, respectively. Four cases died of primary ear malignancy and 2 of intercurrent disease. No severe side effect or complication has been observed. Radiotherapy combined with surgery is a promising modality for treatment of ear malignancy. (author)

  5. Immunohistochemistry quantification by a digital computer-assisted method compared to semiquantitative analysis / Método digital assistido por computador de quantificação imunohistoquímica comparado à análise semiquantitativa

    Scientific Electronic Library Online (English)

    Leandro Luongo de, Matos; Elaine, Stabenow; Marcos Roberto, Tavares; Alberto Rosseti, Ferraz; Vera Luiza, Capelozzi; Maria Aparecida da Silva, Pinhal.

    2006-10-01

    Full Text Available SciELO Brazil | Language: English Abstract in portuguese OBJETIVO: Comparar a quantificação da imunomarcação através de um método digital assistido por computador à bem estabelecida análise semiquantitativa. MÉTODO: A marcação citoplasmática de galectina-3 foi obtida por reações imunohistoquímicas em 25 casos de carcinoma bem-diferenciado da glândula tire [...] óide. Determinou-se o índice de expressão da análise semiquantitativa que associa a convencional fração de área de células marcadas com os escores de intensidade da imunoexpressão, com base na observação visual qualitativa. O método digital assistido por computador foi desenvolvido com o uso de um programa de análise de imagem (ImageLab®). Três parâmetros foram obtidos: (1) porcentagem de células marcadas; (2) intensidade de imunoexpressão digital e (3) índice de expressão digital. O método proposto resulta na análise numérica da intensidade de imunoexpressão. RESULTADOS: Houve importante correlação entre as intensidades de imunoexpressão obtidas pelos dois métodos (coeficiente de correlação de Pearson, r=0,71, p=0,0001). O mesmo foi observado entre os índices de expressão (coeficiente de correlação de Pearson, r=0,66, p=0,0001). DISCUSSÃO: Os resultados de intensidade de imunoexpressão obtidos com o emprego do método digital assistido por computador foram concordantes com os escores da análise semiquantitativa. Entretanto, os resultados alcançados com o emprego do método digital podem resolver a discordância entre diferentes observadores com relação a esta intensidade de imunomarcação. Além disso, o método proposto não categoriza os resultados em grupos, o que torna a análise imunohistoquímica numericamente mensurável individualmente, aumentando seu poder diagnóstico e, sobretudo, prognóstico. Abstract in english PURPOSE: To compare immunostaining quantification obtained by a digital computer-assisted method with the well-established semiquantitative analysis. METHODS: Cytoplasmic staining of galectin-3 was obtained by standard immunohistochemical reactions in 25 cases of well-differentiated thyroid carcinom [...] a. The expression index that associates the conventional area fraction of labeled cells with the immunostaining intensity score based on visual qualitative observation was used as the semiquantitative analysis. A digital computer-assisted method is described based on the use of an image processing program (ImageLab®). Three parameters were obtained: (1) percentage of labeled cells; (2) digital immunostaining intensity, and (3) digital expression index. The proposed method allows numerical analysis of the immunostaining intensity. RESULTS: There was a strong correlation between the immunostaining intensity obtained by the two methods (Pearson correlation coefficient, r = 0.71, P = 0.0001). The same was observed between expression indexes (Pearson correlation coefficient, r = 0.66, P = 0.0001). CONCLUSION: Results obtained with our proposed digital computer-assisted method for immunoexpression analysis were concordant with the semiquantitative analysis. In addition, digital values can also resolve disagreement among different observers about the quality of staining intensity because the digital method does not classify the results into groups, but rather provides a numerical value for each individual case; thus, it increases the diagnostic and, more importantly, the prognostic sensitivity of the immunohistochemical analysis.

  6. Comparação dos tratamentos do carcinoma espinocelular avançado do esofago pela teleterapia exclusiva e pela teleterapia associada à braquiterapia / Comparison of treatment using teletherapy (external beam radiation) alone versus teletherapy combined with brachytherapy for advanced squamous cell carcinoma of the esophagus

    Scientific Electronic Library Online (English)

    Renato, Samea; Laercio Gomes, Lourenço.

    2011-12-01

    Full Text Available RACIONAL: O câncer do esôfago ainda constitui neoplasia de difícil tratamento e de prognóstico muito ruim. OBJETIVO: Comparar a resposta do tratamento exclusivo com teleterapia isolada versus teleterapia associada à braquiterapia endoluminal de doentes portadores de carcinoma espinocelular avançado [...] do esôfago. MÉTODO: Foram estudados 49 doentes portadores de carcinoma espinocelular avançado do esôfago médio em estádio clínico III (TNM). Os doentes foram divididos em dois grupos de doentes. O primeiro grupo foi submetido à teleterapia exclusiva com acelerador linear de partículas, dose média de 6000 cGy e o segundo à teleterapia na dose de 5040 cGy associada à braquiterapia endoluminal com Iridium 192 na dose de 1500 cGy. A braquiterapia foi iniciada uma a duas semanas após o término da teleterapia e dividida em três aplicações semanais de 500 cGy. Foram avaliadas as variáveis idade, sexo, raça, hábitos (tabagismo e etilismo), índice de massa corpórea (IMC), complicações com o tratamento, benefícios (melhora da dor e satisfação alimentar) e sobrevivência. RESULTADOS: Os resultados quanto a qualidade de vida (satisfação alimentar, paliação da disfagia e dor) foram melhores no grupo submetido à teleterapia associada a braquiterapia. A sobrevivência foi maior no grupo de teleterapia associada a braquiterapia. CONCLUSÃO: Apesar do índice de cura do câncer espinocelular do esôfago ser quase nulo quando tratado com irradiação isolada, esta terapêutica constitui-se em uma forma de tratamento paliativo para grande parte dos doentes em que existe contra-indicação cirúrgica. Abstract in english BACKGROUND: Squamous cell carcinoma of the esophagus is still a difficult tumor to treat with very poor prognosis. AIM: To compare the response to teletherapy treatment (external beam radiotherapy) alone versus teletherapy combined with brachytherapy for patients with advanced squamous cell carcinom [...] a of the esophagus. METHODS: Were studied 49 patients with advanced squamous cell carcinoma of the esophagus on clinical stage III (TNM-1999). They were separated into two groups. The first, underwent radiation therapy alone with linear accelerator of particles, average dose of 6000 cGy and the second to external beam radiation therapy at a dose of 5040 cGy combined with brachytherapy with Iridium 192 at a dose of 1500 cGy. Brachytherapy started one to two weeks after the end of teletherapy, and it was divided into three weekly applications of 500 cGy. Age, gender, race, habits (smoking and drinking), body mass index (BMI), complications with treatment benefits (pain relief and food satisfaction) and survival were analyzed. RESULTS: The quality of life (food satisfaction, and pain palliation of dysphagia) were better in the group treated with external beam radiation therapy combined with brachytherapy. Survival was higher in the brachytherapy combined with external beam radiation therapy alone. CONCLUSION: Although the cure rate of squamous cell cancer of the esophagus is almost nil when treated with irradiation alone, this therapy is a form of palliative treatment for most patients in whom surgical contraindication exists.

  7. Effects of sodium hyaluronate in children with recurrent upper respiratory tract infections: results of a randomised controlled study.

    Science.gov (United States)

    Macchi, A; Castelnuovo, P; Terranova, P; Digilio, E

    2013-01-01

    Hyaluronic acid is a major component of many extracellular matrices that plays a role in the regulation of vasomotor tone and mucous gland secretion, and in the modulation of the inflammatory process in upper and lower airways. This pilot study was aimed at evaluating the effects of nasal washes with 9 mg nebulised sodium hyaluronate given for 15 days per month over 3 months in 75 paediatric patients with recurrent upper respiratory tract infections (URTI). Eligible patients were randomized to treatment with nasal washes containing 9 mg sodium hyaluronate plus saline solution or saline alone, according to an open-label, parallel group design, with blind observer assessment. Ciliary motility, which was assessed based on a 0-3 point rating scale (0 = absent, 1 = less than 5 minutes, 2 = greater than or equal to 5 and ? 10 minutes, 3 = greater than 10 minutes) was the primary study endpoint. The secondary efficacy variables included cytological (presence of neutrophils, eosinophils and mast cells), microbiological (presence of bacteria and mycetes), endoscopical (presence of adenoid hypertrophy and biofilm) and clinical (presence of rhinitis, post-nasal drip, nasal dyspnoea) parameters. The two treatment groups (mean age 7.5 years, 53percent of males) were comparable for baseline data, except a higher mean age in the control group than in the treated group. Treatment with 9 mg sodium hyaluronate was associated with significantly greater improvements (p less than 0.001 between groups) in primary outcome ciliary motility [odds ratio (OR) 13.61; 95 percent CI 4.51-41.00 in the univariate regression analysis that examined the probability of improvement]. Treatment with 9 mg sodium hyaluronate was also significantly superior to saline alone in adenoid hypertrophy (p less than 0.001; OR 14.72; 95 percent CI 4.74-45.68), presence of bacteria (p = 0.026; OR 2.95; 95 percent CI 1.15-7.55), neutrophils (p = 0.002; OR 4.51; 95 percent CI 1.75-11.62), rhinitis (p = 0.040; OR 10.47; 95 percent CI 3.10-35.31), nasal dyspnoea (p = 0.047; OR 3.80; 95 percent CI 1.09-13.19) and biofilm (p = 0.049; OR 9.90; 95 percent CI 2.61-37.47). Advantages of 9 mg of sodium hyaluronate over control on post-nasal drip and presence of mycetes (although evident) did not reach the level of statistical significance. The superiority of the treated group over saline alone was confirmed in a multivariate logistic regression analysis that took into account age as confounding factor. The number of days of absence from school was significantly lower in the 9 mg sodium hyaluronate group compared to controls (p less than 0.001 between groups). A 3-month intermittent treatment with 9 mg sodium hyaluronate with nasal washes plus saline solution was associated with significant improvements in ciliary motility and in cytological, microbiological, endoscopic and clinical outcomes compared to saline, in children with recurrent URTI. PMID:23527715

  8. Fatores de risco para otite média aguda recorrente: onde podemos intervir? - uma revisão sistemática da literatura / Systematic literature review of modifiable risk factors for recurrent acute otitis media in childhood

    Scientific Electronic Library Online (English)

    José Faibes, Lubianca Neto; Lucas, Hemb; Daniela Brunelli e, Silva.

    2006-04-01

    Full Text Available SciELO Brazil | Languages: English, Portuguese Abstract in portuguese OBJETIVO: Revisar evidências sobre fatores de risco modificáveis para otite média aguda recorrente. FONTE DOS DADOS: MEDLINE sem restrição de linguagem de janeiro de 1966 até julho de 2005, utilizando descritores "acute otitis media/risk factors". Obtiveram-se 257 artigos. Desses, incluíram-se ensai [...] os clínicos randomizados, coortes, estudos de caso-controle e transversais que tiveram análise dos fatores de risco modificáveis para desenvolvimento de otite média aguda recorrente como objetivo principal e com amostras de indivíduos de até 18 anos. Excluíram-se, exceto quando relevantes, revisões não-sistemáticas, relatos de casos e série de casos, além de diretrizes de sociedades médicas. SÍNTESE DOS DADOS: Identificaram-se nove fatores de risco ligados ao hospedeiro e oito ligados ao ambiente. Do primeiro grupo, classificaram-se como modificáveis alergia, anormalidades craniofaciais, refluxo gastroesofágico e presença de adenóides. Na segunda categoria, incluíram-se infecção de vias aéreas superiores, cuidados em creches, presença de irmãos/tamanho da família, fumo passivo, aleitamento materno e uso de chupetas. Posteriormente, classificaram-se os fatores de risco de acordo com níveis de evidência. CONCLUSÕES: Os fatores de risco estabelecidos para otite média aguda recorrente e passíveis de intervenção foram uso de chupetas e cuidados em creche. Os fatores de risco prováveis foram privação do leite materno, presença de irmãos, anormalidades craniofaciais, fumo passivo e presença de adenóides. Nenhum fator modificável foi classificado como pouco provável. Entre os que precisam ser melhor estudados estão alergia, refluxo gastroesofágico e fumo passivo na gestação. Abstract in english OBJECTIVE: Review evidence about modifiable risk factors for recurrent acute otitis media. SOURCE OF DATA: MEDLINE with no language restriction, from January 1966 to July 2005, using descriptors "acute otitis media/risk factors". Two hundred and fifty-seven articles were obtained. These included ran [...] domized clinical trials, cohorts, case-control and cross-sectional studies that contained analyses of modifiable risk factors for the development of recurrent acute otitis media as the main objective and with samples of individuals up to the age of 18 years. Except when relevant, the following were excluded: non-systematic reviews, reports of cases, series of cases, and medical society guidelines. SUMMARY OF DATA: Nine risk factors linked to the host and eight linked to the environment were identified. Of the first group, allergy, craniofacial abnormalities, gastroesophageal reflux and the presence of adenoids were classified as modifiable. In the second category, upper airway infections, day care center attendance, presence of siblings/family size, passive smoking, breastfeeding and use of pacifiers were included. Afterwards, the risk factors were classified in accordance with levels of evidence. CONCLUSIONS: The risk factors established for recurrent acute otitis media and capable of being modified were the use of pacifiers and care in daycare centers. The probable risk factors were privation of mother's milk, presence of siblings, craniofacial abnormalities, passive smoking and presence of adenoids. No modifiable factor was classified as unlikely. Among those that need further study are allergy, gastroesophageal reflux and passive smoking during gestation.

  9. Rapid detection of sentinel lymph node metastases in different techniques and comparison in low-grade breast carcinomas / Detección rápida de metástasis en ganglio centinela y comparación de diferentes técnicas en carcinomas de mama de bajo grado

    Scientific Electronic Library Online (English)

    Luz F, Sua; Nhora M, Silva; Martha Vidaurreta, Quim; Virginia, de la Orden; Silvia, Veganzones; Sara, Rafael; María L, Maestro de las Casas.

    2012-01-01

    Full Text Available SciELO Colombia | Language: English Abstract in spanish Introducción: El rol de la biopsia del ganglio centinela ha revolucionado el tratamiento del cáncer de mama. Tomar esta determinación disminuye la morbilidad de una linfadenectomía axilar completa. El objetivo del estudio es analizar el valor del ganglio centinela en los tumores de mama de tipo hist [...] ológico de bajo grado y estudiarlos con las técnicas de hematoxilina y eosina, inmunohistoquímica y molecular de reacción en cadena de la polimerasa en tiempo real cuantitativa (RT-PCR). Material y métodos: En un estudio piloto se estudiaron 21 pacientes con diagnóstico histológico de carcinoma mucinoso, metaplásicos o adenoide quístico a quienes se les realizó la técnica del ganglio centinela. Una vez extraído el ganglio se envió a anatomía patológica, donde se fragmentó y evaluó. Para el estudio en el laboratorio de biología molecular se utilizó entre 25% y 50% del ganglio. Resultados: Se estudiaron 32 ganglios centinelas, correspondientes a 21 pacientes; 29 (90.6%) fueron negativos en el examen histopatológico y en la determinación molecular, 2 (6.3%) positivos en ambas técnicas y en 1 (3.1%) hubo discrepancia en el diagnóstico, éste fue positivo con la RT-PCR cuantitativa y negativo en el estudio histológico (H&E), el cual, por inmunohistoquímica (IHC), se diagnosticó como células tumorales aisladas (CTA). Conclusión: Cuando se compararon las técnicas de hematoxilina y eosina, inmunohistoquímica y la técnica molecular RT-PCR cuantitativa, se comprobó mayor sensibilidad en la técnica molecular, lo que permite disminuir los falsos negativos y tener un mejor diagnóstico de las metástasis en los ganglios centinelas. Las pacientes con carcinomas de tipo histológico de bajo grado tienen una alta sobrevida, un comportamiento tumoral menos agresivo y menor compromiso ganglionar en el momento del diagnóstico. Abstract in english Introduction: The role of sentinel node biopsy has revolutionized breast cancer treatment. This determination reduces the mobility of a complete axillary lymphadenectomy. The aim of our study is to analyze the value of sentinel node in low-grade histological breast tumors, studied with hematoxylin a [...] nd eosin techniques, Immunohistochemistry, and molecular chain reaction in real-time quantitative polymerase (RT-PCR). Materials and methods: In a pilot study we studied a total of 21 patients with histological diagnosis of mucinous carcinoma, adenoid cystic carcinoma, and medullar carcinoma that underwent the sentinel node technique. Once the lymph node was removed, it was sent to pathology, where it was fragmented and evaluated, using between 25% and 50% of the lymph node for molecular biology laboratory studies. Results: The sentinel nodes studied were 32, corresponding to the 21 patients. Of the 32 lymph nodes analyzed, 29 (90.6%) were negative on histopathological examination and the molecular identification, 2 (6.2%) were positive in both techniques and 1 (3.125%) lymph node was positive with quantitative RT-PCR and negative in histology (H&E), which – subsequently by immunohistochemistry (IHC) – was diagnosed as isolated tumor cells (ITC). Conclusion: When comparing the techniques of hematoxylin and eosin, immunohistochemistry, and molecular RT-PCR technique, we found greater sensitivity of molecular techniques; this can reduce the false negative and improve diagnosis of sentinel node metastases. Patients with low histological grade carcinomas have high survival rates, less aggressive tumor behavior, and reduced lymph node at diagnosis.