WorldWideScience
1

Adenoid cystic carcinoma of the head and neck; Les carcinomes adenoides kystiques de la tete et du cou  

Energy Technology Data Exchange (ETDEWEB)

The adenoid cystic carcinoma or cylindroma develop principally from salivary glands. It is the most frequently at the level of head and neck. The aim of this work is to analyse the therapy data and to determine the prognostic factors of adenoid cystic carcinomas through a retrospective study. (N.C.)

Haddad, H.; Riahi, H.; Chekrine, T.; Benchakroun, N.; Jouhadi, H.; Tawfiq, N.; Sahraoui, S.; Benider, A. [Centre d' oncologie Ibn-Rochd, Casablanca, (Morocco)

2007-11-15

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Carcinome papillaire intra-kystique du sein: à propos de trois cas  

Science.gov (United States)

Le Carcinome papillaire intra-kystique du sein est une entité très rare et représente 0,5 à 1% de l'ensemble des carcinomes mammaires. Il se caractérise généralement par une croissance lente avec un bon pronostic. Nous rapportons 03 nouveaux cas prouvés histologiquement, chez des patientes traitées par chirurgie radicale ou conservatrice, suivie d'une radiothérapie sur le sein en place et une hormonothérapie à base de tamoxifen chez les deux patientes avec des récepteurs hormonaux positifs. Les trois patientes sont en bon contrôle locorégionale avec des suivis post-thérapeutiques de 12 à 18 mois. PMID:25419333

El Mazghi, Abderrahman; Bouhafa, Touria; Loukili, Kaoutar; El Kacemi, Hanan; Lalya, Issam; Kebdani, Taieb; Hassouni, Khalid

2014-01-01

3

Exclusive irradiation of cyst adenoid carcinomas: contribution of a dose complement in stereotactic mode; Irradiation exclusive des carcinomes adenoides kystiques: role d'un complement de dose en mode stereotaxique  

Energy Technology Data Exchange (ETDEWEB)

The cyst adenoid carcinoma is a rare malignant tumor that reaches principally the salivary glands; It is characterized by a clinical aggressiveness, the presence of peri neural invasions, frequent local recurrences and a high rate of metastases dissemination at delayed distance. The treatment is surgery with a postoperative adjuvant radiotherapy. for the patients suffering of inoperable tumors, the exclusive radiotherapy gives bad results with tests of use of heavy particles. The place of a hypo fractionated treatment on a stereotactic mode has not been evaluated, especially in dose complement after three dimensional irradiation. The purpose was to answer the following question if the Cyberknife was useful to deliver a complement of hypo fractionated stereotactic dose for the inoperable head and neck tumors. The limited number of patients does not allow a definitive conclusion. however, this therapy option seems interesting for the inoperable tumors subject to the management of the toxicity induced by the treatment. The evaluation of the irradiation volumes remains the critical element for the feasibility of this kind of protocol. (N.C.)

Coche-Dequeant, B.; Lefebvre, J.L.; Lacornerie, T.; Lartigau, E. [Centre Oscar-Lambret, 59 - Lille (France); Attar, M. [King Abdulaziz University Hospital, Jeddah, Arabie saoudite (Saudi Arabia)

2009-10-15

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Literature review on the role of radiotherapy in the treatment of nasopharyngeal cystic adenoid carcinomas about two cases; Revue de la litterature sur la place de la radiotherapie dans le traitement des carcinomes adenoides kystiques du nasopharynx a propos de deux cas  

Energy Technology Data Exchange (ETDEWEB)

The authors discuss the characteristics and the radiotherapy treatment procedures of cystic adenoid carcinomas, and more precisely the treatment of two of such cases of nasopharyngeal carcinomas. The first one had an incomplete resection surgery followed by curing radiotherapy: he has then been in local-regional control situation for 8 months. The second one had lung metastases, was treated chemotherapy and radiotherapy (decompressive treatment), and died six months after diagnosis. Radiotherapy is considered to be the treatment basis, whereas chemotherapy is a matter of controversy. Short communication

Hemmich, M.; Hassouni, K.; Elkacemi, H.; Errachdi, A.; Mouhajir, N.; Zaidi, H.; Benjaafar, N. [Institut national d' oncologie, Rabat (Morocco)

2011-10-15

5

Enlarged adenoids  

Science.gov (United States)

... Mouth breathing may lead to the following symptoms: Bad breath Cracked lips Dry mouth Persistent runny nose or nasal congestion Enlarged adenoids may also cause sleep problems. A child may: Be restless while sleeping ...

6

Lymphangiome kystique de l'arrière-cavité des épiploons  

Science.gov (United States)

Le lymphangiome kystique de l'arrière-cavité des épiploons est une localisation exceptionnelle dont le diagnostic est suspecté par la radiologie et confirmé par l'examen anatomo-pathologique. L'exérèse chirurgicale constitue le traitement de choix. PMID:25018798

El Barni, Rachid; Lahkim, Mohamed; Fihri, Jawad Fassi; Mejdane, Abdelhadi; Bouchama, Rachid; Achour, Abdessamad

2014-01-01

7

All about Adenoids  

Science.gov (United States)

... develops other ways to fight germs. Adenoids usually shrink after about age 5, and by the teenage years they often practically disappear. When Adenoids Swell Because adenoids trap germs that enter the body, ...

8

Adenoid Cystic Carcinoma  

Science.gov (United States)

... t y g H Types of Cancer Navigating Cancer Care Coping and Emotions Research and Advocacy Survivorship Blog About Us s You are here Home > Types of Cancer > Adenoid Cystic Carcinoma Adenoid Cystic Carcinoma This is ...

9

Enlarged Adenoids (For Parents)  

Science.gov (United States)

... Lessons? Visit KidsHealth in the Classroom What Other Parents Are Reading Keeping Portions Under Control Recipe: Fruity ... Expect Ebola: What to Know Enlarged Adenoids KidsHealth > Parents > Diseases & Conditions > Ears, Nose, Throat/Speech & Hearing > Enlarged ...

10

Carcinome épidermoïde verruqueux palpébrale: à propos d'un cas  

OpenAIRE

Le carcinome épidermoïde verruqueux est une forme rare du carcinome épidermoïde et se caractérise par une malignité essentiellement locale. La localisation palpébrale est exceptionnelle. Nous rapportons le cas d'une patiente de 70 ans, suivi en consultation pour tumeur palpébrale volumineuse simulant un kératoacanthome de l’œil droit. La biopsie révèle un carcinome épidermoïde verruqueux. Une exérèse chirurgicale de la totalité de la tumeur avec reconstruction de la paupiè...

Tzili, Nazih; El Yamouni, Oubaida; El Khaoua, Mahfoud; Mellal, Zakaria; Sefiani, Sanae; Berraho, Amina

2014-01-01

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Carcinome épidermoïde verruqueux palpébrale: à propos d'un cas  

Science.gov (United States)

Le carcinome épidermoïde verruqueux est une forme rare du carcinome épidermoïde et se caractérise par une malignité essentiellement locale. La localisation palpébrale est exceptionnelle. Nous rapportons le cas d'une patiente de 70 ans, suivi en consultation pour tumeur palpébrale volumineuse simulant un kératoacanthome de l’œil droit. La biopsie révèle un carcinome épidermoïde verruqueux. Une exérèse chirurgicale de la totalité de la tumeur avec reconstruction de la paupière ont été réalisées. On n'a pas noté de récidive pendant les 6 mois suivant le traitement chirurgical. Il s'agit du quatrième cas de carcinome épidermoide verruqueux à localisation palpébrale reporté dans la littérature. PMID:25400860

Tzili, Nazih; El Yamouni, Oubaida; El Khaoua, Mahfoud; Mellal, Zakaria; Sefiani, Sanae; Berraho, Amina

2014-01-01

12

Carcinome hépatocellulaire non fibrolamellaire sur foie sain  

OpenAIRE

Le carcinome hépatocellulaire (CHC) survient le plus souvent sur foie de cirrhose. Sa survenue sur un foie sain est exceptionnelle et pose un véritable défit diagnostique pour le clinicien. Nous rapportons l'observation d'un patient de 53 ans, sans antécédents pathologiques notables qui fût admis pour exploration d'une douleur de l'hypochondre droit évoluant depuis quelques mois avec une exacerbation récente, associée à un amaigrissement important et une altération de l’état gé...

Bouomrani, Salem; Kilani, Ichrak; Nouma, Hane?ne; Slama, Alaeddine; Beji, Maher

2014-01-01

13

Sphenoid sinus adenoid cystic carcinoma  

OpenAIRE

Introduction: The sphenoid adenoid cystic carcinoma is a rare malign neoplasm, in the head and neck and when located in the paranasal sinuses, it is formed in the minor salivary glands. It grows slowly and is characterized by a large invasion of the adjacent tissues, and also has a large capacity of metastasis. The surgery associated with post-operative radiotherapy is used as treatment. Objective: To describe a case of sphenoid sinus adenoid cystic carcinoma in a male, black, 62 year patient...

Marambaia, Otavio; Gomes, Amaury Machado; Marambaia, Pablo Pinillos; Pimentel, Kleber; Almeida, Fabio Siqueira Costa

2008-01-01

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Sphenoid sinus adenoid cystic carcinoma  

Directory of Open Access Journals (Sweden)

Full Text Available Introduction: The sphenoid adenoid cystic carcinoma is a rare malign neoplasm, in the head and neck and when located in the paranasal sinuses, it is formed in the minor salivary glands. It grows slowly and is characterized by a large invasion of the adjacent tissues, and also has a large capacity of metastasis. The surgery associated with post-operative radiotherapy is used as treatment. Objective: To describe a case of sphenoid sinus adenoid cystic carcinoma in a male, black, 62 year patient. Case Report: N.L.B., 62 years of age, male, had bloody rhinorrhea for 6 months associated with bilateral nasal obstruction. The nasofibroscopy showed lesion of polypoid aspect in the left nasal cavity. He was submitted to biopsy and the anatomopathological exam showed adenoid cystic carcinoma and the patient was forwarded to oncology. Conclusions: The importance of conducting the differential diagnosis between chronic nasosinusal infection and nasosinusal tumors.

Marambaia, Otavio

2008-12-01

15

Assessment of Adenoid Size in Children  

Directory of Open Access Journals (Sweden)

Full Text Available Adenoid hypertrophy is one of the most common diseases in the pediatric population, and can cause nasal obstruction, snoring, mouth breathing, and alteration in facial development in children. Flexible fiberoptic nasolaryngoscopey was the gold standard method for evaluation of adenoid and nasopharyngeal obstruction. The aim of this study was evaluation results and agreement of flexible flexible fiberoptic nasolaryngoscopey, Adenoid lateral x-ray and intraoperative observation diagnosis of adenoid hypertrophy and its intensity. In a cross-sectional and descriptive-analytical study, 50 pediatric patients who had suffered from nasal obstruction and mouth breathing were selected in this study to undergo adenoidectomy. The size of adenoid measured by flexible fiberoptic nasolaryngoscopey, lateral neck radiography and intraoperative observation of adenoid size. Results of three studied methods in diagnosis of adenoid hypertrophy and its severity were compared. Twenty two of patients were boy and 28 of them were girl. Mean age of patients was 6.26 ± 1.81 year in the range of 3-12 year. The agreement rate of Lateral Neck Radiography in determination of adenoid hypertrophy with intraoperative observation of adenoid size and flexible fiberoptic nasolaryngoscopey was 70 and 50%, respectively and between flexible fiberoptic nasolaryngoscopey and intraoperative observation of adenoid size was 72% and between three methods was 48%. The agreement rate of each three methods in diagnosis of adenoid hypertrophy was 100%. Significantly strong correlation was found between intraoperative observation of adenoid size with lateral neck radiography and flexible fiberoptic nasolaryngoscopey and poor correlation was found between Lateral Neck Radiography and flexible fiberoptic nasolaryngoscopey.

2008-01-01

16

Adenoid cystic carcinoma of trachea.  

Science.gov (United States)

A 20-year-old male, presented with cough, haemoptysis, breathlessness and wheezing for the past one month. Contrast enhanced computerised tomographic (CECT), scan of chest and fibreoptic bronchoscopy revealed an endotracheal mass that on histopathological examination showed adenoid cystic carcinoma of trachea. Magnetic resonance imaging (MRI) scan of chest confirmed involvement of adjacent prevertebral, para-oesophageal and subcarinal lymph nodes rendering the tumour inoperable. PMID:15515830

Vigg, Ajit; Mantri, Sumant; Vigg, Avanti; Vigg, Arul

2004-01-01

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Pneumatose kystique intestinale révélée par une sténose d'une anastomose gastro-jéjunale: à propos d'un cas  

Science.gov (United States)

La pneumatose kystique intestinale est la présence de bulles gazeuses dans la paroi et les séreuses du tube digestif. Il s'agit d'une pathologie bénigne, rare, de diagnostic radiologique et de traitement médical. Nous rapportons le cas d'un homme âgé de 42ans, opéré il y a 6ans pour une sténose du bulbe duodénal d'origine ulcéreuse, il avait bénéficié d'une gastro-entéro-anastomose avec bivagotomie tronculaire. Il a été hospitalisé pour des vomissements associés à des épigastralgies. le patient a bénéficié d'une fibroscopie oeso-gastro-duodénale qui a trouvé une stase gastrique gênant toute exploration, ce qui a conduit à la réalisation d'une tomodensitométrie abdominale qui a objectivé un énorme estomac de stase en amont d'une sténose de l'anastomose gastro jéjunale, une pneumatose kystique intestinale et un pneumopéritoine. Le patient a été opéré et l'exploration a trouvé une ascite, un volumineux estomac de stase et des adhérences entre le grêle et le colon droit, sièges de la pneumatose, provoquant un tour de spire (volvulus) de l'ancienne anastomose gastro-jéjunale. L'estomac était atone. Une gastrectomie des 2/3 emportant l'ancienne anastomose suivie d'une anastomose type Finsterer manuelle a été réalisée. Les suites post opératoires étaient simples. La pneumatose kystique intestinale est une affection bénigne, de diagnostic radiologique. Le scanner permet d’étudier la diffusion des gaz dans les séreuses digestives. Son traitement est habituellement médical alors que ses complications peuvent relever d'un traitement chirurgical comme pour notre patient. PMID:24255731

El Matiallah, Mohammed Amine; El Bouhaddouti, Hicham; Mouaqit, Ouadii; Benjelloun, El Bachir; Ousadden, Abdelmalek; Taleb, Khalid Ait

2013-01-01

18

Adenoidal size in lateral roentgenogram of skull  

Energy Technology Data Exchange (ETDEWEB)

Adenoid is a kind of tonsil located in the posterior wall of the nasopharynx. Enlargement of the adenoid can produce obstruction of the nasopharynx and eustachian tube. Disturbance in discharge of nasal and paranasal secretions can be a cause of chronic rhinitis, sinusitis and otitis media. The diagnosis of enlarged adenoid by inspection is difficult due to its location. In the lateral roentgenogram of the skull the anterior wall of the adenoid is sharply delineated by air in the nasopharynx. The authors measured the sizes of adenoid and nasopharynx and calculated the adenoid-nasopharyngeal ratio (AN ratio) from 1,000 simple skull lateral roentgenograms of the children between the age of 0 to 16 years. Adenoid size is gradually increasing in the children up to 9 years of age but almost uncharged in the older age group. The AN ratio is highest in the age group of 8-9 years. In the age groups above 9 years of age the AN ratio is gradually decreased due to atrophic changes of the adenoid.

Won, H. S.; Byun, Y. S.; Hahm, C. K.; Kim, J. J. [College of Medicine, Hanyang University, Seoul (Korea, Republic of)

1983-03-15

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Carcinome hépatocellulaire non fibrolamellaire sur foie sain  

Science.gov (United States)

Le carcinome hépatocellulaire (CHC) survient le plus souvent sur foie de cirrhose. Sa survenue sur un foie sain est exceptionnelle et pose un véritable défit diagnostique pour le clinicien. Nous rapportons l'observation d'un patient de 53 ans, sans antécédents pathologiques notables qui fût admis pour exploration d'une douleur de l'hypochondre droit évoluant depuis quelques mois avec une exacerbation récente, associée à un amaigrissement important et une altération de l’état général. L'examen clinique notait une hépatomégalie ferme et douloureuse. L’échographie abdominale montrait une masse hétérogène du secteur latéral droit du foie faisant 10 cm de grand axe. La TDM abdominale montrait une masse tissulaire, hétérogène, à vascularisation artérielle importante, mesurant 10 cm de diamètre et occupant le secteur latéral droit du foie. Cette tumeur comprime la branche portale droite sans signes d'extension. Il n'y avait pas d'adénopathie ni d’épanchement intra abdominal. La ponction biopsique écho-guidée avait conclu à un CHC non fibrolamellaire. Le bilan biologique, en particulier les transaminases, le taux de prothrombine, l’électrophorèse des protéines sanguine et l'alpha foeto-protéine, était sans anomalies. Les sérologies de l'hépatites virales B et C ainsi que la recherche des auto anticorps spécifiques des hépatites auto immunes et le bilan cuprique étaient aussi négatives. Vue l’âge, le stade avancé de la tumeur et l'altération de l’état général la conduite thérapeutique était de s'abstenir. PMID:25419293

Bouomrani, Salem; Kilani, Ichrak; Nouma, Hanène; Slama, Alaeddine; Beji, Maher

2014-01-01

20

Adenoid reservoir for pathogenic biofilm bacteria.  

Science.gov (United States)

Biofilms of pathogenic bacteria are present on the middle ear mucosa of children with chronic otitis media (COM) and may contribute to the persistence of pathogens and the recalcitrance of COM to antibiotic treatment. Controlled studies indicate that adenoidectomy is effective in the treatment of COM, suggesting that the adenoids may act as a reservoir for COM pathogens. To investigate the bacterial community in the adenoid, samples were obtained from 35 children undergoing adenoidectomy for chronic OM or obstructive sleep apnea. We used a novel, culture-independent molecular diagnostic methodology, followed by confocal microscopy, to investigate the in situ distribution and organization of pathogens in the adenoids to determine whether pathogenic bacteria exhibited criteria characteristic of biofilms. The Ibis T5000 Universal Biosensor System was used to interrogate the extent of the microbial diversity within adenoid biopsy specimens. Using a suite of 16 broad-range bacterial primers, we demonstrated that adenoids from both diagnostic groups were colonized with polymicrobial biofilms. Haemophilus influenzae was present in more adenoids from the COM group (P = 0.005), but there was no significant difference between the two patient groups for Streptococcus pneumoniae or Staphylococcus aureus. Fluorescence in situ hybridization, lectin binding, and the use of antibodies specific for host epithelial cells demonstrated that pathogens were aggregated, surrounded by a carbohydrate matrix, and localized on and within the epithelial cell surface, which is consistent with criteria for bacterial biofilms. PMID:21307211

Nistico, L; Kreft, R; Gieseke, A; Coticchia, J M; Burrows, A; Khampang, P; Liu, Y; Kerschner, J E; Post, J C; Lonergan, S; Sampath, R; Hu, F Z; Ehrlich, G D; Stoodley, P; Hall-Stoodley, L

2011-04-01

21

Primary adenoid cystic carcinoma: an extremely rare eyelid tumor.  

Science.gov (United States)

Cutaneous adenoid cystic carcinoma is an extremely rare clinical entity. Among the few cases reported in the literature, most had contiguous involvement from the lacrimal gland. Primary adenoid cystic carcinoma is one of the rarest eyelid tumors. The authors report a case of adenoid cystic carcinoma arising from the lower eyelid. PMID:21629138

Ali, Mohammad Javed; Honavar, Santosh G; Naik, Milind N; Vemuganti, Geeta K

2012-01-01

22

Carcinome épidermoïde du sein: à propos de 3cas et revue de la littérature  

Science.gov (United States)

Les carcinomes épidermoides du sein sont rares. Ils sont d'origine métaplasiques. Leur histogénèse est controversée. La présentation clinique et mammographique n'est pas spécifique, l'aspect kystisé des lésions et la présence de nécrose sont recherchés à l’échographie mammaire. Le diagnostic est histologique. Ce cancer est réputé être peu lymphophile et non hormonodépendant. Le traitement rejoint celui des carcinomes infiltrants canalaires et repose sur la chirurgie, la radiothérapie et la chimiothérapie. Le pronostic est péjoratif. Nous rapportons trois cas de carcinome épidermoide du sein colligés au service de Gynécologie obstétrique II au CHU Hassan II de Fès et une revue de la littérature. PMID:22891096

Alaoui, Fatima Zohra Fdili; Benkirane, Saad; Chaara, Hekmat; Bouguern, Hakima; Melhouf, Moulay Abdilah

2012-01-01

23

[Adenoid basal carcinoma and adenoid cystic carcinoma of the uterine cervix].  

Science.gov (United States)

Adenoid basal carcinoma and adenoid cystic carcinoma are rare primary cervical neoplasms occurring in postmenopausal women. They are generally regarded as distinct entities on the basis of their distinctive morphology and a different biological behaviour. Although the separation of these two entities is still mandatory, some rare complex cases may show overlapping pathological features and are difficult to classify. We report a case of composite cervical tumor with both types of carcinoma, an in situ epidermoid carcinoma and a hitherto undescribed clear cell component, each with a different morphology and immunophenotype. The adenoid basal component is mainly immunoreactive for cytokeratin KL1. The adenoid cystic component is strongly stained for smooth muscle actin and is associated with a hyaline stroma immunostained for collagen IV. PMID:9296580

Lefrancq, T; de Muret, A; Michalak, S; Lhuintre, Y; Fetissof, F

1997-07-01

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Carcinome neuroendocrine du sein: à propos d'un cas et revue de la littérature  

OpenAIRE

Le carcinome neuroendocrine primitif du sein est une tumeur rare qui a été reconnue par la dernière édition de la classification OMS du cancer du sein publiée en 2003. Le diagnostic est évoqué sur des critères morphologiques et confirmé par l'expression des marqueurs neuroendocrines (chromogranine et synaptophysine) par plus de 50% des cellules tumorales. Nous rapportons un nouveau cas de carcinome neuroendocrine primitif du sein, et à travers une revue de la littérature, nous dét...

El Fatemi, Hinde; Hammas, Nawal; Moumna, Kaoutar; Bedahou, Mouhcine; Mellas, Nawfel; Mesbahi, Omar

2012-01-01

25

Carcinome épidermoïde du sein: à propos de 3cas et revue de la littérature  

OpenAIRE

Les carcinomes épidermoides du sein sont rares. Ils sont d'origine métaplasiques. Leur histogénèse est controversée. La présentation clinique et mammographique n'est pas spécifique, l'aspect kystisé des lésions et la présence de nécrose sont recherchés à l’échographie mammaire. Le diagnostic est histologique. Ce cancer est réputé être peu lymphophile et non hormonodépendant. Le traitement rejoint celui des carcinomes infiltrants canalaires et repose sur la chirurgie, la ra...

Alaoui, Fatima Zohra Fdili; Benkirane, Saad; Chaara, Hekmat; Bouguern, Hakima; Melhouf, Moulay Abdilah

2012-01-01

26

Chimioembolisation des carcinomes hépatocellulaires : essai d'optimisation de la procédure  

OpenAIRE

Avec environ 700 000 décès en 2008, le carcinome hépatocellulaire se situe au 3ème rang de la mortalité par cancers dans le monde. La chimioembolisation est le traitement recommandé chez les patients atteints d'un carcinome hépatocellulaire de stade intermédiaire B de la classification Barcelona Clinic Liver Cancer. Cette technique de radiologie interventionnelle consiste en l'injection intraartérielle d'un agent anticancéreux à l'aide d'un vecteur (lipiodol ou microsphères d'embo...

Boulin, Mathieu

2011-01-01

27

Carcinome colloïde du sein: à propos d'un cas  

Science.gov (United States)

Nous rapportons le cas d'une tumeur colloïde du sein chez un homme. Cette situation rare interpelle par son mode de découverte. Nous avons pris en charge un homme de 60 ans atteint d'une lésion rétro-aréolaire droite classée cliniquement T4b N1 M0 et suspecte radiologiquement. L'analyse histologique (microbiopsie) a conclu à un carcinome colloïde muqueux associé à une petite composante canalaire classique de grade I de SBR du sein. Les traitements complémentaires associent mastectomie, curage, chimiothérapie, radiothérapie et hormonothérapie. Le cancer du sein est rare chez l'homme. Le carcinome colloïde est exceptionnel puisqu'il représente seulement 1 à 6% de l'ensemble des cancers du sein. Il est encore plus rare chez l'homme. Ces tumeurs touchent une population spécifique et ont un meilleur pronostic que les autres types prépondérant dans les cancers du sein chez l'homme. A travers cette observation et une revue de la littérature, nous essaierons de discuter les principales caractéristiques anatomo-cliniques et évolutives de cette forme rare du cancer du sein. PMID:24772222

Laabadi, Kamilia; Jayi, Sofia; Alaoui, Fatimazohra Fdili; Bouguern, Hakima; Chaara, Hikmat; Melhouf, My Abdelilah

2013-01-01

28

Palliative Radiotherapy in a Patient with Pulmonary Adenoid Cystic Carcinoma  

OpenAIRE

Primary adenoid cystic carcinoma in the lung is very rare, so its clinicopathologic characteristics have usually been extrapolated from the salivary disease. However, the clinical courses of pulmonary adenoid cystic carcinomas may be different from those of salivary disease, and individual differences may also exist. I report here on a case of a patient who was initially diagnosed as pulmonary adenoid cystic carcinoma with liver metastases and the tumor showed extreme radiosensitivity, but it...

Kim, Bokyong

2007-01-01

29

Lacrimal gland adenoid cystic carcinoma treated with intraarterial chemotherapy  

OpenAIRE

Adenoid cystic carcinoma is a malignant tumor of glandular tissue and progresses with local relapse and distant metastasis. In this report, we present a case of lacrimal gland adenoid cystic carcinoma who treated by multimodal approach with intraarterial chemotherapy. A 32-year-old woman was diagnosed with adenoid cystic carcinoma (solid variant) of the left lacrimal gland. Neoadjuvant intraarterial cisplatin, intravenous doxorubicin, and orbital exenteration were performed. The patient was f...

Tu?rken, Orhan; Duman, Cengiz; Bas?eki?m, C??nar; O?zgu?n, Alpaslan; Karago?z, Bu?lent; Kandemi?r, Emin Go?khan; Haholu, Aptullah; Bi?lgi?, Og?uz

2009-01-01

30

Primary adenoid cystic carcinoma of the orbital apex.  

Science.gov (United States)

Adenoid cystic carcinoma is an uncommon malignant tumor of epithelial origin typically arising from salivary glands. Orbital involvement may occur via direct or perineural spread from a lacrimal gland or sinonasal source. Primary orbital adenoid cystic carcinoma without involvement of the lacrimal gland is rare. The authors report a 53-year-old woman who was examined for insidious monocular vision loss and was found to have a primary adenoid cystic carcinoma of the orbital apex and cavernous sinus. Systemic workup for a primary source, including ipsilateral lacrimal gland biopsy, was negative. One must maintain a high index of suspicion for adenoid cystic carcinoma when evaluating orbital tumors. PMID:23034685

Walsh, Ryan D; Vagefi, M Reza; McClelland, Collin M; Alonso-Basanta, Michelle; Newman, Jason G; Farkas, Tunde; Tamhankar, Madhura A

2013-01-01

31

Paediatric refractory rhinosinusitis secondary to hypertrophied adenoids: management and review of literature.  

Directory of Open Access Journals (Sweden)

Full Text Available Background /Objectives: Hypertrophied adenoids are the most common cause of refractory sinusitis in paediatric age. We study 42 cases of patients of chronic adenoiditis with adenoid facies and refractory chronic rhinosinusitis managed by endoscopic assisted adenoidectomy (EAA and conventional adenoidectomy (CA. Materials and method: 42 cases of chronic refractory sinusitis with adenoid facies secondary to hypertrophied adenoids were randomized into 2 groups during the study period of 12 months from August 2012 to July 2013. Group A (n=21 underwent endoscope assisted adenoidectomy and Group B(n=21 underwent conventional adenoidectomy. Result: Endoscopic assisted adenoidectomy proves to be more effective in managing adenoid facies and chronic refractory rhinosinusitis with adenoid hyperplasia. Conclusion: Visualization of the adenoid mass using endoscope helps complete removal of the diseased adenoids. Endoscopic assisted adenoidectomy is treatment of choice in adenoid facies and chronic refractory rhinosinusitis with adenoid hyperplasia and more effective than conventional adenoidectomy.

Gautham MK

2014-06-01

32

Perineural spread in adenoid cystic carcinoma  

International Nuclear Information System (INIS)

This is a report of adenoid cystic carcinoma occurred in the palate in 30-year-old patient with a complaint of exophytic mass.The authors diagnosed it as adenoid cystic carcinoma by the clinical examination, radiographic findings and histopathological findings. The obtained results are as follows: 1. In the clinical examination, asymptomatic exophytic mass of palate was observed. 2. In radiographic findings, soft tissue mass infiltrated the left maxillary sinus, nasal cavity, infraorbital fossa, hard palate, pterygopalatine fossa and pterygoid plate, and enhanced soft tissue mass was also observed in CT. 3. In histopathological findings, tubular and solid patterns of glandular structures were observed and the infiltration of tumor cells into the nerve fibers was also observed. 4. Two years after radical surgery, radiation therapy and chemotherapy, the perineural spread to orbital area was observed. 5. Much longer follow-up than 5 years is needed for early diagnosis of recurrence and distant metastasis.

33

Exfoliative cytology of tracheobronchial adenoid cystic carcinoma.  

Science.gov (United States)

The cytologic findings in the bronchial brushing and washing specimens of three cases of tracheobronchial adenoid cystic carcinoma are reported and compared with those reported in the literature. The cytodiagnostic features including cribriform epithelial clusters, epithelial balls, branching epithelial cylinders, cellular hyaline mucous globules, and a heretofore unemphasized diagnostic clue in exfoliative cytology--naked hyaline globules in washing smears, are illustrated and discussed. PMID:8872436

Chen, K T

1996-08-01

34

Adenoid cystic carcinoma of the lacrimal gland.  

Science.gov (United States)

Adenoid cystic carcinoma (ACC) of the lacrimal gland is a rare tumor from the epithelial structure. It is rare in children. The authors report a case of ACC in a girl child. Extensive excision of the tumor is advised to prevent later recurrences. Local control can be better achieved by a combination of radiochemotherapy as ACC has been shown to recur event after 10 years. PMID:14620193

Thavaraj, Vasantha; Sridhar, M R; Sethi, A; Arya, L S

2003-09-01

35

Adenoid cystic carcinoma initially diagnosed and treated as hemangioma.  

Science.gov (United States)

Adenoid cystic carcinoma initially diagnosed and treated as hemangioma. A case diagnosed as having a hemangioma of the soft palate according to clinical and arteriographic findings is discussed. Recurrence appeared one year after embolization. Arteriography showed no vascular lesion and histopathologic study revealed an adenoid cystic carcinoma. It is stated that imaging studies may be insufficient. PMID:7725921

Figuerola, E; Añó, T; Risco, J; Guiral, H; Reverter, C; Flores, J C

1995-01-01

36

Le carcinome urothélial plasmocytoïde de la vessie : une entité histologique rare au pronostic sombre  

Science.gov (United States)

Résumé Introduction : Le carcinome urothélial plasmocytoïde est une variante histologique rare du carcinome urothélial. Seule une centaine de cas ont été décrits dans la littérature. Dans cette étude, nous faisons état de deux nouvelles observations. En combinant nos résultats à ceux des différentes séries décrites dans la littérature, nous tentons de définir les caractéristiques cliniques et pathologiques ainsi que l’approche thérapeutique de cette pathologie. Observations : Deux nouveaux cas de carcinome urothélial plasmocytoïde ont été diagnostiqués et pris en charge dans notre établissement. Les 2 patients étaient des hommes de 76 ans en moyenne. L’hématurie était le principal symptôme. Les deux patients ont subi une résection transurétrale de la vessie. Le stade tumoral au moment du diagnostic était avancé dans les deux cas (respectivement T3N0M0 et T3N1M0). Les deux patients ont été traités par cystoprostatectomie. L’analyse histologique de la pièce opératoire, complétée par une étude immunohistochimique, a confirmé le diagnostic de carcinome urothélial plasmocytoïde. Le premier patient est décédé un mois plus tard des suites d’une embolie pulmonaire. Le deuxième patient est décédé au bout de deux mois après avoir reçu deux cycles de chimiothérapie adjuvante. Les données recueillies sur les différentes séries décrites dans la littérature vont dans le même sens que nos données, à savoir un stade avancé au moment du diagnostic et un pronostic sombre. Conclusion : Le carcinome urothélial plasmocytoïde est une variante histologique rare et agressive du carcinome urothélial. Le diagnostic se fait souvent à un stade avancé, et le pronostic est peu encourageant. Le traitement repose le plus souvent sur une cystectomie, suivie d’une chimiothérapie adjuvante à base de cisplatine. L’intérêt d’une chimiothérapie néo-adjuvante n’a pas encore été établi. PMID:25408815

Benazzouz, Mohamed Hicham; Essatara, Younes; Elsayegh, Hachem; Iken, Ali; Benslimane, Lounis; Znati, Kaoutar; Nouini, Yassine

2014-01-01

37

Carcinome neuroendocrine du sein: à propos d'un cas et revue de la littérature  

Science.gov (United States)

Le carcinome neuroendocrine primitif du sein est une tumeur rare qui a été reconnue par la dernière édition de la classification OMS du cancer du sein publiée en 2003. Le diagnostic est évoqué sur des critères morphologiques et confirmé par l'expression des marqueurs neuroendocrines (chromogranine et synaptophysine) par plus de 50% des cellules tumorales. Nous rapportons un nouveau cas de carcinome neuroendocrine primitif du sein, et à travers une revue de la littérature, nous détaillons les aspects épidémiologiques, morphologiques et immuno-histochimiques de cette tumeur rare. PMID:23330031

El Fatemi, Hinde; Hammas, Nawal; Moumna, Kaoutar; Bedahou, Mouhcine; Mellas, Nawfel; Mesbahi, Omar

2012-01-01

38

Paediatric refractory rhinosinusitis secondary to hypertrophied adenoids: management and review of literature.  

OpenAIRE

Background /Objectives: Hypertrophied adenoids are the most common cause of refractory sinusitis in paediatric age. We study 42 cases of patients of chronic adenoiditis with adenoid facies and refractory chronic rhinosinusitis managed by endoscopic assisted adenoidectomy (EAA) and conventional adenoidectomy (CA). Materials and method: 42 cases of chronic refractory sinusitis with adenoid facies secondary to hypertrophied adenoids were randomized into 2 groups during the study p...

Mk, Gautham; Ravishankara S; Naik, Sudhir M.; Sathya P2; Mohan Appaji; Shankarnarayan Bhat; Ravi Karumbiah

2014-01-01

39

[Adenoid cystic carcinoma of the upper eyelid].  

Science.gov (United States)

Adenoid cystic carcinoma (ACC) is a rare epithelial malignancy, which tends to grow slowly. ACC is an intractable neoplasm due to its ability to invade perineural spaces. Local recurrence after excision is not unusual. ACC most commonly arises in the lacrimal gland. Very rarely, ACC originates from accessory lacrimal gland tissue. Here, we present a patient with a large ACC of the central upper eyelid, which had been misdiagnosed and treated as a chalazion without histological examination. Its origin most likely is an accessory lacrimal gland. PMID:17447072

Paarlberg, J C; den Hollander, J C; Hafezi, F; Paridaens, D

2007-12-01

40

Cystic adenoid carcinoma of sphenoidal sinus  

Directory of Open Access Journals (Sweden)

Full Text Available Adenoid cystic carcinoma (ACC is a malignant epithelial tumor of the salivary glands, which usually gives metastases late, but his persistent and aggressive because of its ability to infiltrate surrounding tissue and nerve fibers. ACC of paranasals sinus may spread following the path of the cranial nerves. The close relationship with vital structures prevents complete tumor resection leaving positive margins up to 80 % of patients, mainly at the base of the skull with a high rate of local recurrences and late metastases, aggressive due to its ability to infiltrate surrounding tissue and nerve fibers.

Fuente-Cañibano R

2012-01-01

41

Lacrimal gland adenoid cystic carcinoma treated with intraarterial chemotherapy  

Directory of Open Access Journals (Sweden)

Full Text Available Adenoid cystic carcinoma is a malignant tumor of glandular tissue and progresses with local relapse and distant metastasis. In this report, we present a case of lacrimal gland adenoid cystic carcinoma who treated by multimodal approach with intraarterial chemotherapy. A 32-year-old woman was diagnosed with adenoid cystic carcinoma (solid variant of the left lacrimal gland. Neoadjuvant intraarterial cisplatin, intravenous doxorubicin, and orbital exenteration were performed. The patient was followed for 32 months without relapse. Achievement of long-time survival for this disease supports studies that show benefit of intraarterial chemotherapy.

Orhan TÜRKEN

2009-01-01

42

Stimulation of adenoidal lymphocytes by Alloiococcus otitidis.  

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Otitis media with effusion (OME) is characterized by persistent effusion in the middle ear cavity and by chronic inflammation in the middle ear mucosa. Alloiococcus otitidis, a gram-positive aerobic bacterium, has been isolated in middle ear effusion, and by means of sensitive polymerase chain reaction detection assays it has been detected in as many as 20% of middle ear aspirates of patients with OME. Because A otitidis may freely interact with leukocytes in the middle ear effusion, it may potentially modulate the inflammatory reaction in OME. To study the nature of these interactions, we applied an in vitro assay in which killed A otitidis bacteria were incubated with peripheral blood and adenoidal mononuclear cells. The expression of the proliferation-associated surface marker CD69 was then measured in B lymphocytes and in CD4+ helper and CD8+ cytotoxic-suppressor T lymphocytes by means of multicolor flow cytometry. Alloiococcus otitidis induced the expression of CD69 in both peripheral blood and adenoidal T and B cells. Among the T cells, the cytotoxic-suppressor T lymphocytes were preferentially activated. It was also tested whether A otitidis would have an effect in another cytotoxic and immunoregulatory system, namely, the induction of natural killer cell activity in peripheral blood mononuclear cells. However, the effect was minimal compared with that of Salmonella minnesota or Staphylococcus aureus. The results show that A otitidis has a unique immunostimulatory capacity in vitro that is mainly confined to CD8+ T lymphocytes. PMID:11051437

Tarkkanen, J; Himi, T; Harimaya, A; Atshushi, H; Carlson, P; Ylikoski, J; Mattila, P S

2000-10-01

43

Carcinome épidermoïde de l’urètre masculin révélé par une rupture spontanée de l’urètre  

OpenAIRE

Le carcinome épidermoïde de l’urètre masculin est une tumeur rare, les tumeurs de l’urètre tous types confondus représentant moins de 1 % des tumeurs de l’appareil urinaire. Le pronostic reste défavorable malgré un traitement chirurgical énergique. La radiochimiothérapie semble être un traitement prometteur, mais son rôle doit être défini par d’autres études.

Ghorbel, Jilani; Hafsia, Ghassen; Derouiche, Amine; Jrad, Anis; Chebil, Mohamed

2011-01-01

44

Carcinome mucineux primitif cutané: à propos de deux cas et d'une revue de la literature  

OpenAIRE

Le carcinome mucineux primitif cutané est une tumeur annexielle rare, développée à partir des glandes sudoripares. Il se localise en générale à l'extrémité céphalique, surtout la région périorbitaire. Nous rapportons deux observations d'un carcinome mucineux primitif de la face et de la région axillaire, chez deux patients âgés de 60 ans. L’étude histologique montrait une prolifération tumorale dermohypodermique, faite de cellules organisées en cordons, en amas et en massi...

Souaf, Ihsane; Ameurtesse, Hassania; Debbagh, Fatema Zehra; Idrissi, Karima; Znati, Kawter; Amarti, Affaf

2014-01-01

45

Palliative radiotherapy in a patient with pulmonary adenoid cystic carcinoma.  

Science.gov (United States)

Primary adenoid cystic carcinoma in the lung is very rare, so its clinicopathologic characteristics have usually been extrapolated from the salivary disease. However, the clinical courses of pulmonary adenoid cystic carcinomas may be different from those of salivary disease, and individual differences may also exist. I report here on a case of a patient who was initially diagnosed as pulmonary adenoid cystic carcinoma with liver metastases and the tumor showed extreme radiosensitivity, but it also underwent an aggressive clinical course. Adenoid cystic carcinoma is usually known to be a slowly growing tumor, but it may rapidly disseminate, like in this patient. Therefore, the factors predicting aggressive behavior should be determined and the treatment might be individualized according to the primary sites and on the patient's basis. PMID:19746187

Kim, BoKyong

2007-12-01

46

Primary Adenoid Cystic Carcinoma Presenting as an Orbital Apex Tumor  

OpenAIRE

Primary adenoid cystic carcinoma occurring in the orbital apex is rare. We present the clinical features of a patient who initially presented with the clinical and radiologic features of an orbital pseudotumor. He developed features of orbital apex syndrome and repeat imaging showed a tumor of the orbital apex with intracranial invasion. He underwent radical skull base surgery and pathologic examination revealed adenoid cystic carcinoma in the orbital apex with a normal lacrimal apparatus. He...

Venkitaraman, Ramachandran; Madhavan, Jayaprakash; Ramachandran, Krishnankuttynair; Abraham, Elizabeth; Rajan, Balakrishnan

2008-01-01

47

A case of subglotitic adenoid cystic carcinoma  

Directory of Open Access Journals (Sweden)

Full Text Available Introcuction: Adenoid cystic carcinoma (ACC is the second most common salivary glands tumor and the most common malignant tumor of minor salivary glands and also submandibular glands; however ACC of the larynx and trachea is rare. These tumors generally present in subglottic region as smooth submucosal solid mass without ulceration. Their primary symptoms are often as respiratory problems. Materials and Methods: This study was done on a woman, 54 years, with subglottic ACC that presented with exertional dyspnea, stridor, cough and hoarseness. After confirmation of diagnosis with biopsy, the patient underwent a total laryngectomy and then postoperative radiotherapy. Conclusion: During one year follow up, the patient did not show any evidence of local recurrence or distant metastasis. Surgery with free margins in combination with postoperative radiotherapy was recommended to treat laryngeal ACC in order to obtain better survival.  

Masoud Naghibzadeh

2010-04-01

48

Adenoid Cystic Carcinoma of External Auditory Canal  

Directory of Open Access Journals (Sweden)

Full Text Available Adenoid cystic carcinoma is extremely rare tumour that accounts for approximately 5% of primary malignancy of external auditory canal. These tumours are related with a high risk of recurrences and significant morbidities from surgical management and adjuvant radiotherapy. Despite the aggressive management for these tumours, many patients succumb to distant metastasis, making overall prognosis of these tumours poor. Although ACC of EAC has been reported in 5th decade, but its occurrence in young patient is very rare. We report a rare case of ACC in a young 22 years old female, who presented with ear canal mass and ear pain. Biopsy suggested mass to be ACC. Patient underwent wide local excision followed by adjuvant radiotherapy.

Sanjeev Bhagat

2012-04-01

49

Le carcinome verruqueux de la vulve: à propos de quatre cas  

Science.gov (United States)

Le cancer verruqueux de la vulve est une variante rare et bien différenciéedu carcinome épidermoïdedont les particularités diagnostiques, thérapeutiques et pronostiques méritent d’être distinguées. Il se caractérise par son importante croissance exophytique sans infiltration de la membrane basale. Son évolution est surtout locale rarement métastatique. Il est l'indication d'un traitement chirurgical exclusif avec exérèse large sans curage ganglionnaire de principe. La radiothérapie n'apporte aucun bénéfice en survie. Le pronostic est relativement bon mais grevé par les récidives locales. Nous rapportons quatre cas de carcinome verruqueux de la vulve colligés au Service de Chirurgieà l'Institut National d'Oncologie Rabat, nous discuterons à travers une revue de littérature, leurs modalités diagnostiques thérapeutiques et évolutives. PMID:25328599

Boujoual, Majdouline; Hachi, Hafid; Rimani, Mouna; El Khannoussi, Basma; Bougtab, Abdesslam

2014-01-01

50

Cervical Adenoid Basal Carcinoma: A Case Report  

Science.gov (United States)

Adenoid basal carcinoma (ABC) is a rare epithelial tumor of the cervix. It makes up approximately 1% of all cervical adenocarcinomas. Rare cases have been associated with common cervical epithelial tumors. We present a case of ABC associated with typical squamous cell carcinoma. A 54-year-old post-menopausal woman underwent D&C for vaginal bleeding. Histologically, the tumor was characterized by small cells with a narrow cytoplasm, making up islands and cords. Peripheral palissading in the cells surrounding the cystic areas that contained central cellular debris and keratin was noted. The patient underwent total hysterectomy, bilateral salpingo-oophorectomy, pelvic lymphadenectomy and omentectomy. Large cell keratinized type squamous cell carcinoma areas in the cervix were noted besides the limited ABC areas. After surgery, the patient was treated with radiation therapy. A retroperitoneal metastasis was found on the first year and chemotherapy was administered. The patient has no evidence of disease 27 months after the first diagnosis. ABC makes up quite a rare group of cervical cancers and should be kept in mind during the evaluation so that a differentiation can be made with tumors with similar morphology as it can show various histological patterns, and can be seen together with more aggressive cancers. PMID:25207054

Argon, Asuman; ?ener, Alper; Zekio?lu, Osman; Terek, Co?an; Özdemir, Necmettin

2012-01-01

51

Adenoid cystic carcinoma of breast: Recent advances  

Science.gov (United States)

Adenoid cystic carcinoma (ACC) of the breast is a rare special subtype of breast cancer characterized by the presence of a dual cell population of luminal and basaloid cells arranged in specific growth patterns. Most breast cancers with triple-negative, basal-like breast features (i.e., tumors that are devoid of estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 expression, and express basal cell markers) are generally high-grade tumors with an aggressive clinical course. Conversely, while ACCs also display a triple-negative, basal-like phenotype, they are usually low-grade and exhibit an indolent clinical behavior. Many discoveries regarding the molecular and genetic features of the ACC, including a specific chromosomal translocation t(6;9) that results in a MYB-NFIB fusion gene, have been made in recent years. This comprehensive review provides our experience with the ACC of the breast, as well as an overview of clinical, histopathological, and molecular genetic features. PMID:25516849

Miyai, Kosuke; Schwartz, Mary R; Divatia, Mukul K; Anton, Rose C; Park, Yong Wook; Ayala, Alberto G; Ro, Jae Y

2014-01-01

52

The mutational landscape of adenoid cystic carcinoma.  

Science.gov (United States)

Adenoid cystic carcinomas (ACCs) are among the most enigmatic of human malignancies. These aggressive salivary gland cancers frequently recur and metastasize despite definitive treatment, with no known effective chemotherapy regimen. Here we determined the ACC mutational landscape and report the exome or whole-genome sequences of 60 ACC tumor-normal pairs. These analyses identified a low exonic somatic mutation rate (0.31 non-silent events per megabase) and wide mutational diversity. Notably, we found mutations in genes encoding chromatin-state regulators, such as SMARCA2, CREBBP and KDM6A, suggesting that there is aberrant epigenetic regulation in ACC oncogenesis. Mutations in genes central to the DNA damage response and protein kinase A signaling also implicate these processes. We observed MYB-NFIB translocations and somatic mutations in MYB-associated genes, solidifying the role of these aberrations as critical events in ACC. Lastly, we identified recurrent mutations in the FGF-IGF-PI3K pathway (30% of tumors) that might represent new avenues for therapy. Collectively, our observations establish a molecular foundation for understanding and exploring new treatments for ACC. PMID:23685749

Ho, Allen S; Kannan, Kasthuri; Roy, David M; Morris, Luc G T; Ganly, Ian; Katabi, Nora; Ramaswami, Deepa; Walsh, Logan A; Eng, Stephanie; Huse, Jason T; Zhang, Jianan; Dolgalev, Igor; Huberman, Kety; Heguy, Adriana; Viale, Agnes; Drobnjak, Marija; Leversha, Margaret A; Rice, Christine E; Singh, Bhuvanesh; Iyer, N Gopalakrishna; Leemans, C Rene; Bloemena, Elisabeth; Ferris, Robert L; Seethala, Raja R; Gross, Benjamin E; Liang, Yupu; Sinha, Rileen; Peng, Luke; Raphael, Benjamin J; Turcan, Sevin; Gong, Yongxing; Schultz, Nikolaus; Kim, Seungwon; Chiosea, Simion; Shah, Jatin P; Sander, Chris; Lee, William; Chan, Timothy A

2013-07-01

53

Adenoid cystic carcinoma of the tongue.  

Science.gov (United States)

Malignant tumours of the salivary glands in children are extremely rare. We present here a 12-year-old girl initially diagnosed as pleomorphic adenoma on fine needle aspiration biopsy, and adenoid cystic carcinoma (ACC) after the lesion was excised and examined by histopathology. A wide resection of the lesion and bilateral supraomyohyoid neck dissection was performed. To our knowledge this is one of the youngest patients with ACC of the minor salivary glands. Due to its benign histological appearance, the biological agressiveness of ACC is usually underestimated. Although fine needle aspiration cytology (FNAC) is very valuable in diagnosis, cytological variations of pleomorphic adenoma must be considered. ACC of the tongue in a young age group should be treated with wide resection and selective neck dissection if the tumour is localized in places where the risk of metastasis is increased and if there is a clinically palpable lymph node. In such cases the clinician should not avoid radical operations even in a young patient. PMID:10962689

Ustünda?, E; Iseri, M; Aydin, O; Dal, H; Almaç, A; Paksoy, N

2000-06-01

54

Adenoid cystic carcinoma of breast: Recent advances.  

Science.gov (United States)

Adenoid cystic carcinoma (ACC) of the breast is a rare special subtype of breast cancer characterized by the presence of a dual cell population of luminal and basaloid cells arranged in specific growth patterns. Most breast cancers with triple-negative, basal-like breast features (i.e., tumors that are devoid of estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 expression, and express basal cell markers) are generally high-grade tumors with an aggressive clinical course. Conversely, while ACCs also display a triple-negative, basal-like phenotype, they are usually low-grade and exhibit an indolent clinical behavior. Many discoveries regarding the molecular and genetic features of the ACC, including a specific chromosomal translocation t(6;9) that results in a MYB-NFIB fusion gene, have been made in recent years. This comprehensive review provides our experience with the ACC of the breast, as well as an overview of clinical, histopathological, and molecular genetic features. PMID:25516849

Miyai, Kosuke; Schwartz, Mary R; Divatia, Mukul K; Anton, Rose C; Park, Yong Wook; Ayala, Alberto G; Ro, Jae Y

2014-12-16

55

Dedifferentiated adenoid cystic carcinoma of the lacrimal gland.  

Science.gov (United States)

A rare variant of adenoid cystic carcinoma is the dedifferentiated sarcomatoid form, which has previously been reported in the hard and soft palate, maxillary sinus, submandibular glands, and nasal cavity. The authors report the first case of a dedifferentiated sarcomatoid adenoid cystic carcinoma occurring in the lacrimal gland, that of a 52-year-old man. The patient presented with a 4-month history of diplopia, decreased vision, and right upper eyelid swelling. Radiographic imaging showed a soft tissue mass in the extraconal compartment superolateral to the right eye. The patient subsequently underwent surgical debulking. Histologic examination of the tissue revealed classic cribiform adenoid cystic carcinoma and a sarcomatous component consisting of malignant spindle cells and fusiform cells arranged in whorls. Dedifferentiation is a well-established phenomenon in salivary gland tumors that is associated with aggressive behavior and poor prognosis; however, the exact nature of such dedifferentiated neoplasms remains unclear. PMID:21283029

Panarelli, Joseph F; Zoumalan, Christopher I; Mukkamala, Krishna; Maher, Elizabeth A; Iacob, Codrin; Della Rocca, David A

2011-01-01

56

Asynchronous adenoid cystic carcinoma of the urinary bladder  

International Nuclear Information System (INIS)

Histologic variants of prostatic carcinoma are readily reorganized. In this report, we describe a rare variant, adenoid cystic carcinoma in a 75-year-old man previously diagnosed to have transitional cell carcinoma of the urinary bladder. The diagnosis of adenoid cystic carcinoma was made by the characteristic microscopic features of the tumor morpholologically and immunohistochemically. Two months later he was found to have metastatic disease. The patient's treatment consisted of chemotherapy in combination with prednisone and hormonal therapy. Five and half months after diagnosis, he died with metastatic disease. Making this case unique is the asynchronous occurrence of this variant with transitional cell carcinoma of the urinary bladder, which has never be reported in the literature. We discussed the histopathologic and immunohistochemical features of adenoid cystic carcinoma of the prostate with review of literature. (author)

57

Adenoid basal carcinoma of the cervix in a 20-year-old female: a case report  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background Adenoid basal carcinoma of the cervix is a rare condition mostly occurring among postmenopausal women. Although it can be confused with adenoid cystic carcinoma of the cervix, adenoid basal carcinoma has several clinicopathologic features that will allow distinction from adenoid cystic carcinoma. Case presentation This is the case of a twenty-year old African-American female who initially presented with a high-grade squamous intraepithelial lesion on Pap smear, with a subsequent cervical LEEP specimen revealing adenoid basal carcinoma. The lesion showed the characteristic histologic features of adenoid basal carcinoma and was positive for the immunohistochemical marker EMA and negative for collagen IV, further defining the tumor while helping to rule out the possibility of adenoid cystic carcinoma. As far as the authors are aware, this is the youngest reported case of adenoid basal carcinoma to date. Conclusion This case shows that adenoid basal carcinoma can deviate markedly from its typical postmenopausal demographics to affect women as young as 20 years of age. In addition, adenoid basal carcinoma has several identifiable features that will differentiate it from adenoid cystic carcinoma including histologic and cellular morphologies, as well as immunohistochemistry. Treatment for most patients involves hysterectomy, LEEP, or a conization procedure which provides a favorable prognosis because of this lesion's low potential for recurrence and metastasis.

Schnee David

2006-08-01

58

Clinicopathological review and survival characteristics of adenoid cystic carcinoma.  

Science.gov (United States)

To study the clinical characters, the outcomes of treatments and the factors affecting treatment results of adenoid cystic carcinomas at Shahid Sadoughi Hospital and Shahid Ramazanzadeh radiotherapy center, Yazd, Iran. The clinical data of 31 patients with adenoid cystic carcinoma of any anatomic site diagnosed over an 8 year period (2004-2012), were investigated retrospectively. Data regarding patients' characteristics, pathological features and follow-up were obtained from patients records. Survival rate, local recurrence and distant metastasis were analyzed using Kaplan-Meier method. Prognosis factors were analyzed by Log-rank test and Cox regression. The study included31 patients with adenoid cystic carcinoma. The mean age at presentation was 50.2 ± 24.8 years. There were 11 (35.5 %) males and 20 (64.5 %) females with a female predilection (M:F = 0.55:1). Parotid gland was the most common site (8/31, 25.7 %) followed by submandibular gland (7/31, 22.6 %). Perineural invasion was detected in 67.7 % of the cases. Positive surgical status was reported in 48.4 % of the specimens. Metastasis was detected in 25.8 % of the patients and the most common site of distant metastasis was lung. Overall survival rates at 2, 5, and 7 years were 95, 75, and 57 % respectively. Margin status showed significant effect on survival (P value = 0.01). Positive surgical margin is an important factor affecting the prognosis of the patients with adenoid cystic carcinoma. Surgery with negative surgical margin is the first choice of treatment for the patients with adenoid cystic carcinoma. Our findings show that the prognosis of patients with adenoid cystic carcinoma in our center is fair. PMID:25621256

Binesh, Fariba; Akhavan, Ali; Masumi, Omid; Mirvakili, Abbas; Behniafard, Nasim

2015-03-01

59

Radiographic adenoid evaluation - suggestion of referral parameters / Avaliação radiográfica da adenoide - sugestão de parâmetros de referência  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in portuguese OBJETIVO: o objetivo deste estudo foi de investigar a utilidade de medidas radiográficas destinadas à avaliação da tonsila faríngea a serem utilizadas como potenciais parâmetros de encaminhamento. MÉTODOS: crianças de quatro a 14 anos, de ambos os gêneros, que apresentavam queixas referentes à [...] obstrução nasal foram submetidas à radiografia do cavum. Os registros radiográficos (n = 120) foram avaliados de acordo com parâmetros categóricos e quantitativos, e dados resultantes foram comparados ao exame padrão-ouro de videonasofaringoscopia, em relação às suas taxas de acurácia (sensibilidade, valor preditivo negativo, especificidade e valor preditivo positivo). RESULTADOS: os parâmetros radiográficos categóricos apresentaram baixa sensibilidade para a identificação de pacientes portadores de 2/3 de obstrução do espaço coanal. No entanto, alguns destes parâmetros apresentaram especificidades relativamente altas quando 3/4 de obstrução coanal era o ponto de corte de interesse. Dentre as variáveis quantitativas, um modelo matemático se mostrou mais adequado para identificar pacientes com mais de 2/3 de obstrução coanal. CONCLUSÃO: este modelo demonstrou, assim, ser potencialmente útil como método de rastreamento para identificação de pacientes com pelo menos 2/3 de obstrução adenoidiana. Além disso, um dos parâmetros categóricos analisados demonstrou ser relativamente mais útil e potencialmente seguro para eliminar pacientes queixosos com menos de 3/4 de obstrução a serem indicados à adenoidectomia. Abstract in english OBJECTIVE: this study aimed to evaluate the usefulness of current radiographic measurements, which were originally conceived to evaluate adenoid hypertrophy, as potential referral parameters. METHODS: children aged from 4 to 14 years, of both genders, who presented nasal obstruction complaints [...] , were subjected to cavum radiography. Radiographic examinations (n = 120) were evaluated according to categorical and quantitative parameters, and data were compared to gold-standard videonasopharyngoscopic examination, regarding accuracy (sensitivity, negative predictive value, specificity, and positive predictive value). RESULTS: radiographic grading systems presented low sensitivity for the identification of patients with two-thirds choanal space obstruction. However, some of these parameters presented relatively high specificity rates when three-quarters adenoid obstruction was the threshold of interest. Amongst the quantitative variables, a mathematical model was found to be more suitable for identifying patients with more than two-thirds obstruction. CONCLUSION: this model was shown to be potentially useful as a screening tool to include patients with, at least, two-thirds adenoid obstruction. Moreover, one of the categorical parameters was demonstrated to be relatively more useful, as well as a potentially safer assessment tool to exclude patients with less than three-quarters obstruction, to be indicated for adenoidectomy.

Murilo F.N., Feres; Juliana S., Hermann; Ana C., Sallum; Shirley S.N., Pignatari.

2014-06-01

60

Carcinoma adenoide quístico primario de esófago / Primary adenoid cystic carcinoma of esophagus  

Scientific Electronic Library Online (English)

Full Text Available SciELO Peru | Language: Spanish Abstract in spanish Presentamos el caso de un paciente varón de 86 años con 6 meses de disfagia progresiva, baja de peso y edema de miembros inferiores. Tenía anemia microcítica e hipoalbuminemia severas. La radiografía contrastada mostraba al esófago con bordes irregulares que comprometían sus porciones cervical y dis [...] tal. En la tomografía axial computarizada fueron evidentes las adenopatías cervicales, derrame pleural bilateral y pronunciado engrosamiento esofágico. En la endoscopía se observaron desde el área subyacente al cricofaríngeo, lesiones elevadas dispersas, algunas con aspecto nodular y tumoral, que se distribuían una tras otra a lo largo del esófago hasta un área de estenosis (32 cm. de arcada dentaria); la estenosis estaba tapizada con una mucosa irregular y friable. El estudio Histológico reveló carcinoma adenoide quístico de esófago, con inmuno histoquímica positiva a citoqueratina. Mostramos los hallazgos clínico-patológicos e imágenes de este caso y revisamos lo reportado sobre esta rara entidad. Abstract in english We presented the case of a man of 86 years with 6 months of progressive dysphagia, weight loss and edema of lower limbs. He had both severe microcític anemia and hypoalbuminemia. The contrasted x-ray showed the esophagus with irregular edges that compromised their cervical and distal portions. In th [...] e computerized axial tomography cervical adenopathies, bilateral pleural effusion and pronouncing esophagic thickening were evident. In endoscopy dispersed elevated lesions were observed from the underlying area of the cricopharinx, some with nodular and tumor like aspect, that distributed throughout the esophagus until an area of stenosis (32 cm of dental arches); the estenosis was tapestried with an irregular and easy bleeding mucosa. The histological study revealed adenoid cystic carcinoma of esophagus, with positive inmunocytochemical to cytokeratin. We showed the clinical-pathological findings and images of this case and we reviewed reports of this rare entity.

Humberto, Perea Guerrero; Oscar, Frisancho Velarde; Américo, Palomino Portilla.

2008-01-01

61

Tracheal adenoid cystic carcinoma masquerading asthma: A case report  

OpenAIRE

Abstract Background Tracheal tumors are often misdiagnosed as asthma and are treated with inhaled steroids and bronchodilators without resolution. Case Presentation Here, a patient with tracheal adenoid cystic carcinoma who had been previously diagnosed with difficult asthma was reported. The possibility of the presence of localized airway obstruction was raised when the flow-volume curve suggesting fixed airway obstruction, was obtained. Conclusion <...

Kurul Cuneyt; Demircan Sedat; Kokturk Nurdan; Turktas Haluk

2004-01-01

62

Carcinoma adenoide quístico primario de bronquio lobar: Caso clínico / Primary adenoid cystic carcinoma of the lobar bronehus: Case report  

Scientific Electronic Library Online (English)

Full Text Available SciELO Chile | Language: Spanish Abstract in spanish El carcinoma adenoide quístico primario de la vía aérea es una neoplasia muy rara. Reportamos el caso de un paciente de 60 años de edad quien consultó por hemoptisis y disnea de esfuerzo. Una tomografía computarizada del tórax reveló una masa en el bronquio fuente y lobar superior del pulmón derecho [...] . Se realizó una lobectomía superior derecha en manguito. El estudio histopatológico mostró un carcinoma adenoide quístico. Se administró radioterapia adyuvante. La cirugía y la radioterapia son las bases del manejo de este tipo de tumores. Abstract in english Primary airway adenoid cystic carcinoma is very uncommon. We report a 60 years old male consulting for hemoptysis and dyspnea. A chest CAT scan showed a mass in the right superior lobar bronehus. The patient was subjected to a right superior sleeve lobectomy and the pathological study of the surgica [...] l piece revealed an adenoid cystic carcinoma. The patient received adjuvant radiotherapy. Surgery and radiation therapy are the mainstay of treatment for this type of tumors.

LEONIDAS, TAPIAS-VARGAS; LUIS FELIPE, TAPIAS-VARGAS; LEONIDAS, TAPIAS; MARÍA EMMA, GARCÍA; JULIO CÉSAR, MANTILLA; ERNESTO, GARCÍA.

2011-02-01

63

Carcinome mucineux primitif cutané: à propos de deux cas et d'une revue de la literature  

Science.gov (United States)

Le carcinome mucineux primitif cutané est une tumeur annexielle rare, développée à partir des glandes sudoripares. Il se localise en générale à l'extrémité céphalique, surtout la région périorbitaire. Nous rapportons deux observations d'un carcinome mucineux primitif de la face et de la région axillaire, chez deux patients âgés de 60 ans. L’étude histologique montrait une prolifération tumorale dermohypodermique, faite de cellules organisées en cordons, en amas et en massif cribriformes, au sein d'une substance mucoïde. En immunohistochimie les cellules tumorales exprimaient la cytokératine 7, l'EMA et les récepteurs hormonaux. L'actine musculaire lisse a bien marqué les cellules myoépithéliales au niveau de la composante in situ dans un seul cas. Le carcinome mucineux primitif cutané est difficile à différencier d'une métastase mammaire ou digestive. La mise en évidence de carcinome in situ ou de cellules myoépithéliale est en faveur de l'origine cutanée primitive. C'est une tumeur à croissance lente, avec des métastases exceptionnelles. Le traitement est chirurgical et le taux de récidive est très élevé. Et à travers ces deux observations, les auteurs mettent en relief les principaux aspects cliniques, histologiques, thérapeutiques de cette entité avec une revue de la littérature. PMID:25574316

Souaf, Ihsane; Ameurtesse, Hassania; Debbagh, Fatema Zehra; Idrissi, Karima; Znati, Kawter; Amarti, Affaf

2014-01-01

64

[Adenoid cystic carcinoma of the lacrimal gland: report of two cases and literature review].  

Science.gov (United States)

The adenoid cystic carcinoma of the lacrimal gland is a rare malignant orbital tumour, which has a generally poor prognosis. The therapy for adenoid cystic carcinoma of the lacrimal gland remains controversial. We present two cases of patients with adenoid cystic carcinoma of the lacrimal gland, who were treated with radical surgery in combination with radiotherapy. The therapeutic results are discussed with reference to relevant literature reports. PMID:21132626

Manousaridis, K; Stropahl, G; Hingst, V; Guthoff, R

2011-01-01

65

Reprodutibilidade dos métodos radiográficos para avaliação da adenoide / Reliability of radiographic parameters in adenoid evaluation  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese Embora a avaliação radiográfica da hipertrofia de tonsila faríngea tenha sido constantemente debatida, há ainda carência de estudos que testem a confiabilidade da maioria dos parâmetros radiográficos existentes. OBJETIVO: Verificar a reprodutibilidade intra e interexaminadores de vários métodos dest [...] inados à avaliação da tonsila faríngea. Forma de estudo: Estudo de série, metodológico e transversal. MATERIAL E MÉTODO: Quarenta crianças de ambos os sexos, de 4 a 14 anos, foram selecionadas mediante apresentação de queixas de obstrução nasal ou respiração oral, com suspeita de diagnóstico de hipertrofia de tonsila faríngea. Radiografias do cavum faríngeo e telerradiografias ortodônticas foram obtidas e, posteriormente, avaliadas por dois examinadores por meio de instrumentos de avaliação quantitativos e categóricos. RESULTADOS: Todos os parâmetros quantitativos de ambas as modalidades radiográficas apresentaram excelente reprodutibilidade intra e interexaminadores. Dentre os parâmetros categóricos de avaliação da radiografia de cavum, observou-se desempenho relativamente melhor de C-Kurien, C-Wang, C-Fujioka e C-Elwany sobre C-Cohen e C-Ysunza. Em relação aos sistemas destinados à classificação da telerradiografia, C-McNamara apresentou maior reprodutibilidade que C-Holmberg. CONCLUSÃO: A maioria dos instrumentos apresentou reprodutibilidade adequada. No entanto, novas investigações ainda devem ser realizadas com o intuito de determinar a capacidade de cada parâmetro em relação sua acurácia e viabilidade. Abstract in english The assessment of adenoids by x-ray imaging has been the topic of heated debate, but few studies have looked into the reliability of most existing radiographic parameters. OBJECTIVE: This study aims to verify the intra-examiner and inter-examiner reproducibility of the adenoid radiographic assessmen [...] t methods. MATERIALS AND METHODS: This is a cross-sectional case series study. Forty children of both genders aged between 4 and 14 were enrolled. They were selected based on complaints of nasal obstruction or mouth breathing and suspicion of pharyngeal tonsil hypertrophy. Cavum x-rays and orthodontic teleradiographs were assessed by two examiners in quantitative and categorical terms. RESULTS: All quantitative parameters in both x-ray modes showed excellent intra and inter-examiner reproducibility. Relatively better performance was observed in categorical parameters used in cavum x-ray assessment by C-Kurien, C-Wang, C-Fujioka, and C-Elwany over C-Cohen and C-Ysunza. As for orthodontic teleradiograph grading systems, C-McNamara has been proven to be more reliable than C-Holmberg. CONCLUSION: Most instruments showed adequate reproducibility levels. However, more research is needed to properly determine the accuracy and viability of each method.

Murilo Fernando Neuppmann, Feres; Helder Inocêncio Paulo de, Sousa; Sheila Márcia, Francisco; Shirley Shizue Nagata, Pignatari.

2012-08-01

66

Endotracheal irradiation of adenoid cystic carcinoma of the trachea.  

Science.gov (United States)

Management of advanced or recurrent primary tracheal neoplasms has been restricted to palliative external beam irradiation. A patient with recurrent adenoid cystic carcinoma of the trachea was recently treated again by combined external irradiation and endotracheal brachytherapy with iridium 192 sources; the results were dramatic without significant normal tissue toxicity. This endotracheal brachytherapy technique might be applied to tracheal tumors of different histology or more limited extent. PMID:208100

Percarpio, B; Price, J C; Murphy, P

1978-07-01

67

Supraglottic adenoid cystic carcinoma mimicking laryngeal amyloidosis: A case report  

OpenAIRE

Supraglottic adenoid cystic carcinoma (ACC) is extremely rare and may be misdiagnosed as laryngeal amyloidosis. The present report describes a case of supraglottic ACC, which went unrecognized until histopathological examination of the neoplasm 18 months after the first presentation. The present patient presented with progressive hoarseness for half a year and initially required partial resection. Following quick regional recurrence, the patient received a total laryngectomy while refusing ra...

Qian, Xiaoyun; Zhou, Han; Gu, Yajun; Zhang, Yifen; Gao, Xia

2014-01-01

68

Thoracoscopic tracheal resection and reconstruction for adenoid cystic carcinoma.  

Science.gov (United States)

We describe a novel technique of thoracoscopic circumferential tracheal resection and end-to-end anastomosis. A 60-year-old woman presented with wheezing and progressive dyspnea. Computed tomography scan revealed a mass at the lower trachea, and a nitinol mesh stent was implanted by bronchoscopy. After 2 weeks, a complete thoracoscopic tracheal resection and reconstruction was performed. The postoperative course was uneventful. The final pathologic examination confirmed the diagnosis of primary adenoid cystic carcinoma of the trachea. PMID:25555982

Jiao, Wenjie; Zhu, Dezhang; Cheng, Zhaozhong; Zhao, Yandong

2015-01-01

69

Primary tuberculosis of the adenoids in an 11-year-old male presenting with hearing loss: a case report.  

Science.gov (United States)

Hypertrophy of adenoids is usually caused by repeated throat infections, especially viral and bacterial infections, that in microscopic examination reveal reactive lymphoid follicular hyperplasia. Herein, we present an 11-year-old boy who developed hearing loss in his left ear three months before admission, and in direct examination the adenoids were hypertrophied. Histopathological study of the resected adenoid revealed caseating granulomatous inflammation. Based on histopathological and clinical findings, primary tuberculosis of adenoids was suggested which was confirmed by PCR. PMID:23946986

Taghipour-Zahir, S; Baradaranfar, M H; Zolfaghari, A A

2013-04-01

70

Carcinome épidermoïde de l'urètre masculin révélé par une rupture spontanée de l'urètre.  

Science.gov (United States)

RéSUMé: Le carcinome épidermoïde de l'urètre masculin est une tumeur rare, les tumeurs de l'urètre tous types confondus représentant moins de 1 % des tumeurs de l'appareil urinaire. Le pronostic reste défavorable malgré un traitement chirurgical énergique. La radiochimiothérapie semble être un traitement prometteur, mais son rôle doit être défini par d'autres études.Nous rapportons un cas rare de carcinome épidermoïde de l'urètre bulbo-membraneux découvert à un stade localement avancé après observation d'une rupture urétrale transtumorale chez un homme âgé de 70 ans. Le patient a été traité, après drainage vésical, par une irradiation externe associée à une chimiothérapie par cisplatine, et est décédé après progression de la maladie sur un an.La rupture spontanée de l'urètre transtumorale est un mode de découverte exceptionnel témoignant d'une évolution locale défavorable, ce qui rend ces tumeurs difficilement opérables. Cependant, l'espoir actuel réside dans des protocoles thérapeutiques associant radiothérapie et chimiothérapie. PMID:21672490

Ghorbel, Jilani; Hafsia, Ghassen; Derouiche, Amine; Jrad, Anis; Chebil, Mohamed

2011-06-01

71

Metastase axillaire d'un carcinome papillaire de la thyroïde: à propos d'un cas  

Science.gov (United States)

Les métastases axillaires dans le cadre d'un cancer de la thyroïde sont extrêmement rares. Plusieurs hypothèses expliquent ce drainage. Nous rapportons le cas d'un patient de 78 ans ayant pour antécédents chirurgicaux une lobo-isthmectomie en 1987, puis une totalisation chirurgicale en 1997 non documentés, admis en septembre 2008 pour exploration d'une masse latéro-cervicale gauche. Le reste de l'examen clinique révèle la présence de multiples adénopathies axillaires bilatérales. La biopsie exérèse d'une adénopathie axillaire droite (côté controlatéral) retrouve une métastase ganglionnaire d'un carcinome papillaire de la thyroïde avec effraction capsulaire. La tomodensitométrie cervico-thoracique note la présence d'un processus tumoral latéro-cervical gauche, un lobe thyroïdien droit siège de multiples nodules hypodenses, des adénopathies cervicales et axillaires et des lésions suspectes au niveau du parenchyme pulmonaire. Une thyroïdectomie totale avec curage ganglionnaire cervical est décidée, complétée par une ablation des ganglions axillaires macroscopiquement atteints. Des cures d'iode radioactif (IRA-thérapie) sont indiquées. Bien qu'exceptionnelle, la présence de métastases axillaires d'un carcinome thyroïdien est de pronostic péjoratif. On se demande alors si ces patients ne nécessitent pas une prise en charge particulière. Une réflexion à une stratégie thérapeutique est donc nécessaire. PMID:24498461

El Khiati, Rhizlane; Ouaissi, Laila; Rouadi, Sami; Abada, Redallah; Mahtar, Mohamed; Roubal, Mohamed; Janah, Abdellah; Essaadi, Mustapha; Kadiri, Fatmi

2013-01-01

72

Carcinome épidermoïde de l’urètre masculin révélé par une rupture spontanée de l’urètre  

Science.gov (United States)

Résumé Le carcinome épidermoïde de l’urètre masculin est une tumeur rare, les tumeurs de l’urètre tous types confondus représentant moins de 1 % des tumeurs de l’appareil urinaire. Le pronostic reste défavorable malgré un traitement chirurgical énergique. La radiochimiothérapie semble être un traitement prometteur, mais son rôle doit être défini par d’autres études. Nous rapportons un cas rare de carcinome épidermoïde de l’urètre bulbo-membraneux découvert à un stade localement avancé après observation d’une rupture urétrale transtumorale chez un homme âgé de 70 ans. Le patient a été traité, après drainage vésical, par une irradiation externe associée à une chimiothérapie par cisplatine, et est décédé après progression de la maladie sur un an. La rupture spontanée de l’urètre transtumorale est un mode de découverte exceptionnel témoignant d’une évolution locale défavorable, ce qui rend ces tumeurs difficilement opérables. Cependant, l’espoir actuel réside dans des protocoles thérapeutiques associant radiothérapie et chimiothérapie. PMID:21672490

Ghorbel, Jilani; Hafsia, Ghassen; Derouiche, Amine; Jrad, Anis; Chebil, Mohamed

2011-01-01

73

Avaliação da radiografia cefalométrica lateral como meio de diagnóstico da hipertrofia de adenoide Evaluation of lateral cephalometric radiography as a mean of diagnosing adenoids hypertrophy  

OpenAIRE

INTRODUÇÃO: a hipertrofia de adenoide é uma das principais causas da respiração bucal. Entre os métodos utilizados para o diagnóstico dessa condição, os mais precisos são a endoscopia nasal e a ressonância magnética. No entanto, o método mais utilizado, em Odontologia, é a radiografia cefalométrica lateral. OBJETIVO: determinar a eficácia dessa radiografia no diagnóstico da hipertrofia de adenoide, pela sua comparação com a endoscopia nasal. MÉTODOS: foram avaliados 30 ind...

Barbosa, Marcelo Castellucci E.; Luégya Amorim Henriques Knop; Marcus Miranda Lessa3; Telma Martins de Araujo

2009-01-01

74

Association rare d'un adenome pleomorphe et d'un carcinome epithelial myoepithelial de la glande parotide  

OpenAIRE

Le Carcinome épithélial - myoépithélial (CEM) est une tumeur maligne rare des glandes salivaires touchant principalement la glande parotide. Son association avec un adénome pléomorphe est exceptionnelle. Nous rapportons le cas d'une femme de 57 ans avec adénome pléomorphe de la glande parotide évoluant depuis plusieurs années. L'augmentation récente du volume de la glande associée à l'apparition d'adénopathies cervicales homolatérales nous a fait penser à une transformation ma...

Jahidi, Ali; Hemmaoui, Bouchaib; Noureddine, Errami; Youssef, Darouassi; Issam, Rharrasi; Hafsa, Chahdi; Benariba, Fouad

2014-01-01

75

Tomographie par émission de positons au 18F-fluorodesoxyglucose et carcinome épidermoïde des voies aérodigestives supérieures réfractaire au traitement  

OpenAIRE

Nous avons initialement réalisé une étude prospective évaluant l'intérêt de la TEP-TDM au FDG pour le diagnostic de récidive infra-clinique des carcinomes épidermoïdes des voies aéro-digestives supérieures. Nos résultats ont montré d'excellentes performances de l'examen en surveillance systématique, permettant notamment le diagnostic de récidive chez environ 1/3 des patients cliniquement asymptomatiques 1 an après la fin du traitement. Nous avons ensuite étudié le bénéfice...

Abgral, Ronan

2013-01-01

76

Tracheal adenoid cystic carcinoma masquerading asthma: A case report  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background Tracheal tumors are often misdiagnosed as asthma and are treated with inhaled steroids and bronchodilators without resolution. Case Presentation Here, a patient with tracheal adenoid cystic carcinoma who had been previously diagnosed with difficult asthma was reported. The possibility of the presence of localized airway obstruction was raised when the flow-volume curve suggesting fixed airway obstruction, was obtained. Conclusion The presenting case report emphasizes the fact that not all wheezes are asthma. It is critical to bear in mind that if a patient does not respond to appropriate anti-asthma therapy, localized obstructions should be ruled out before establishing the diagnosis of asthma.

Kurul Cuneyt

2004-10-01

77

Adenoid cystic carcinoma arising in the inferior orbit without evidence of lacrimal gland involvement.  

Science.gov (United States)

A 60-year-old woman sought treatment for right orbital fullness and intermittent headache. CT revealed an inferior orbital mass along the inferior rectus muscle. Incisional biopsy revealed an adenoid cystic carcinoma. Orbital exenteration followed by concurrent radiotherapy and chemotherapy was performed. The lacrimal gland was uninvolved by tumor microscopically. Although rare, adenoid cystic carcinoma must be considered in the differential diagnosis of an orbital tumor, because the unusual location of an orbital adenoid cystic carcinoma may make its early detection difficult. PMID:18209657

Lin, Shuai-Chun; Kau, Hui-Chuan; Yang, Ching-Fen; Yang, Muh-Hwa; Tsai, Chieh-Chih; Kao, Shu-Ching; Hsu, Wen-Ming

2008-01-01

78

Carcinoma adenoide quístico parotídeo: soluciones estéticas y funcionales / Adenoid Cystic Carcinoma of the Parotid: an Aesthetic and Functional Solutions  

Scientific Electronic Library Online (English)

Full Text Available SciELO Spain | Language: Spanish Abstract in spanish El carcinoma adenoide quístico supone el 10-30% de las neoplasias malignas parotídeas, su tratamiento se basa en una parotidectomía que incluya el tumor con un adecuado margen de seguridad y la radioterapia postoperatoria dado que permite mejorar el control locorregional de la enfermedad. Revisamos [...] un caso que permite exponer el manejo de las secuelas funcionales y estéticas derivadas de su tratamiento. Consideramos adecuada la reconstrucción inmediata del nervio facial cuando se encuentra clínicamente afecto o englobado por el tumor; así como suplir el defecto de volumen posparotidectomía con un colgajo local. Proponemos la anastomosis nerviosa con injerto de nervio sural de las ramas del nervio facial afectas y el relleno del defecto volumen posparotidectomía con un colgajo de fascia temporo-parietal. Abstract in english Adenoid cystic carcinoma represents 10-30% of all malignant neoplasms in the parotid gland. Treatment is a formal parotidectomy, which includes removing the tumour with an adequate margin and postoperative radiotherapy to improve the locoregional control of the disease. We report a case in order to [...] present the management of the functional and aesthetic consequences obtained from its treatment. When the facial nerve is clinical affected or involved by the tumour, it requires resection and an immediate reconstruction. We suggest the sural nerve graft for the reconstruction of the affected facial branches and the temporo-parietal fascia flap to fill the volume left by the parotidectomy.

Raquel, Villar; Manuel, Acosta; Benito, Ramos; Juan José, Haro; Antonio, Gómez; Tomás, Esteban; Ramsés, Caraballo.

2014-09-01

79

The value of radiological examination in the management of adenoidal hypertrophy in a pediatric population.  

Directory of Open Access Journals (Sweden)

It was concluded that radiological examination in the management of adenoidal hypertrophy had a limited role, increased Radiological Department workload, wastage of resources in addition to unnecessary radiation exposure.

Sami A. Al-Kindy

2003-05-01

80

Adenoid cystic carcinoma of the lacrimal gland : MYB gene activation, genomic imbalances, and clinical characteristics  

DEFF Research Database (Denmark)

To investigate genetic alterations in lacrimal gland adenoid cystic carcinomas (ACCs) with emphasis on the MYB-NFIB fusion oncogene and its downstream targets, MYB rearrangements, and copy number alterations in relation to clinical data and survival.

von Holstein, Sarah L; Fehr, André

2013-01-01

81

Adenoid cystic carcinoma of the salivary gland. Sustained complete response to chemotherapy.  

Science.gov (United States)

A patient developed widely metastatic adenoid cystic carcinoma of the parotid gland after several local recurrences. A complete regression of pleural, pulmonary parenchymal, cutaneous, and bone metastases was seen following therapy with 5-fluorouracil, Adriamycin, and mitomycin C. This is the second complete response to chemotherapy reported for a patient with metastatic adenoid cystic carcinoma of salivary gland origin. Both complete responses and several partial responses have followed treatment with Adriamycin, suggesting that this drug is active in the disease. PMID:6295610

Budd, G T; Groppe, C W

1983-02-15

82

The Role of Adenoid Mast Cells in the Pathogenesis of Secretory Otitis Media  

OpenAIRE

To investigate the possible role of adenoid mast cells in the etiology of secretory otitis media. Between 2001-2002, 25 patients with chronic adenoitis and chronic secretory otitis media and 25 patients with isolated adenoid hypertrophy were included to the study. Adenoidectomy performed to the all patients under general anesthesia. Adenoidectomy specimens were evaluated under the light microscopy and the number of mast cells were calculated for each patient. The number of mast cells were com...

Faruk Oktay, M.; Müzeyyen Y?ld?r?m; Nihal K?l?nç

2007-01-01

83

Intrasellar remote metastasis from adenoid cystic carcinoma of parotid gland: case report.  

Science.gov (United States)

Adenoid cystic carcinoma is a tumor of exocrine glands originating primarily from the minor and major salivary glands, lacrimal gland, bronchus, breast, and intestinal and genital tracts. Intracranial remote metastasis from adenoid cystic carcinoma in salivary gland is quite rare. The authors encountered a case of intrasellar remote metastasis from an adenoid cystic carcinoma of parotid gland origin, presenting with hyponatremia secondary to the syndrome of inappropriate secretion of antidiuretic hormone (SIADH). To our knowledge, this is the first reported case of metastasis from an adenoid cystic carcinoma to intrasellar area. A 78-year-old woman had an adenoid cystic carcinoma in the left parotid gland, which was resected surgically followed by local radiation therapy of 60 Gy. After 4 years, the patient presented with general malaise, followed by disturbed consciousness caused by hyponatremia. The clinical data showed severe hyponatremia induced by SIADH. An intrasellar heterogenous mass lesion compressing the optic chiasm was resected subtotally via an endonasal transsphenoidal approach. Histopathological examination of the tumor specimens revealed adenoid cystic carcinoma, which had identical histological findings as those of the painful superficial cervical lymph nodes resected in the same operation. Tumors such as the present case are easily confused with pituitary adenoma or craniopharyngioma. Although rare, metastasis from tumors including those of salivary gland origin should be considered in the differential diagnosis of unusual pituitary tumors. PMID:16902261

Kawamata, Takakazu; Harashima, Shiho; Kubo, Osami; Hori, Tomokatsu

2006-10-01

84

Radiographic evaluation of adenoidal size in children with allergic perennial rhinitis: still the current method  

International Nuclear Information System (INIS)

Adenoid hypertrophy is known to be the most common cause of nasal obstruction in children; thus, adenoidectomy is one of the most commonly performed surgical procedures in children. Clinical assessment of adenoidal size is difficult, and objective measurement is desirable. The study included 39 children (17 girls and 22 boys, 5-9 years of age, mean age: 6.7 years) with signs of perennial allergic rhinitis and suspicion of adenoidal hypertrophy. To establish the best radiological method to measure the adenoidal size, three different procedures (Johanneson, Fuijoka, and Cohen/Konak) were used. The methods were evaluated against the degree to which the adenoids obstructed the nasopharyngeal space on flexible endoscopy of the postnasal space. Clinical symptomatology was also evaluated against the degree of obstruction. To estimate the correspondence between the results, we used Spearman's correlation test.The radiological method that best correlated with the endoscopic findings was that of Cohen and Konak, but neither radiology nor endoscopic scores correlated well with clinical symptoms. Conclusion: The side-adenoid assessment in allergic children. (author)

85

Cutaneous Adenoid Cystic Carcinoma with Perineural Invasion Treated by Mohs Micrographic Surgery—A Case Report with Literature Review  

OpenAIRE

We report a 58-year-old woman with cutaneous adenoid cystic carcinoma arising on the chest treated with Mohs micrographic surgery. The patient remained tumor-free at 24-month follow-up. To date, only six other cases of cutaneous adenoid cystic carcinoma were reportedly managed by Mohs surgery. Cutaneous adenoid cystic carcinoma has low potential for distant metastasis but is notorious for its aggressive infiltrative growth pattern, frequent perineural invasion, and high risk of local recurren...

Xu, Yaohui G.; Hinshaw, Molly; Longley, B. Jack; Ilyas, Humza; Snow, Stephen N.

2010-01-01

86

Adenoid cystic carcinoma of the tracheobronchial tree: clinicopathology and immunohistochemistry.  

Science.gov (United States)

Adenoid cystic carcinoma of the tracheobronchial tree in five patients was treated surgically and the clinicopathologic manifestations and histogenesis were examined in detail. Symptoms such as cough, dyspnea, hemoptysis, and atelectasis on chest X-ray were present in four patients, and the other patient was asymptomatic. Histologically, growth patterns were classified as tubular, cribriform, and solid. The solid pattern was the most aggressive with extensive perineural invasion. Immunohistochemically, secretory component, lactoferrin, and epithelial membrane antigen were present in the cells lining the gland-like lumen of tissues with the tubular and cribriform patterns, but was rare in those with a solid pattern. Desmin and S-100 protein were detected in the nonlining cells of tissues with all three patterns. These findings suggest that this tumor originates from the myoepithelial cells of the bronchial gland and that the solid pattern was the most poorly differentiated form. PMID:2541282

Ishida, T; Nishino, T; Oka, T; Yasumoto, K; Sugimachi, K; Hara, N; Ohta, M

1989-05-01

87

Macroglossia caused by adenoid cystic carcinoma. Case report.  

Science.gov (United States)

A 33-year-old woman sought medical care at our institution for macroglossia. She had been treated before with tracheostomy and gastrostomy due to an adenoid cystic carcinoma (ACC) of the mobile tongue, in clinical stage IVC. She was subjected to total glossectomy with larynx preservation, modified radical dissection of the right neck and of the left supraomohyoid muscle, as well as reconstruction using a free flap from the rectus abdominus. The histological report described a 15x11 cm solid type ACC of the mobile tongue (grade III), with infiltration to adjacent soft tissues, vascular and lymphatic vessels, as well as two metastatic lymph nodes in the right neck dissection. One month after surgery, bone and bilateral pulmonary tumor activity became evident. In advanced-stage tumors, treatment must be individualized, and when accompanied by severe deterioration of the quality of life, surgery is recommended independently from the extension, provided that a good reconstruction is accomplished. PMID:18521061

Luna Ortiz, Kuauhyama; Carmona Luna, Tania; Herrera Gómez, Angel; Cano Valdez, Ana Maria

2008-06-01

88

Recurrent adenoid cystic carcinoma of the trachea: intraluminal radiotherapy.  

Science.gov (United States)

Malignant neoplasms of the trachea are rare lesions, of which adenoid cystic carcinoma constitutes 30%. A case of extensive tumor recurrent after primary radiotherapy is presented. Surgical resection and radioisotope implantation were impossible. A method was devised for placement of intraluminal iridium 192 by casting six small hollow plastic tubes to the outer circumference of a Silastic endotracheal tube. This was an easy, safe, and effective method of delivering radiation to the trachea while sparing other vital structures and organs. Excellent tumor response and palliation were achieved. The literature is reviewed and the problems in diagnosis of this tumor are discussed. A comprehensive plan for early diagnosis is presented. All current methods of treatment are discussed, and the need for aggressive surgical management is stressed. PMID:228226

Price, J C; Percarpio, B; Murphy, P W; Henderson, R L

1979-01-01

89

Adenoid Cystic Carcinoma Mimicking an Oroantral Fistula: A Case Report  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in english Introduction Adenoid cystic carcinoma (ACC) is one of the most frequent malignant salivary gland tumors, which commonly affects the minor salivary glands of the mouth and is rare in the nose and paranasal sinuses. In the maxillary sinus, ACC can mimic inflammatory diseases and has a poor prognosis [...] . Objective To report a case of a 50-year-old man with ACC of the maxillary sinus whose clinical findings in the alveolar ridge mimicked an oroantral fistula. Case Report An excisional biopsy was performed and histopathologic analysis revealed ACC. Lung metastases and residual tumor in the maxillary sinus were detected by imaging methods. In view of the poor general health of the patient, no new surgical intervention was performed and he was only treated by radiotherapy and follow-up. Conclusion Although rare in the maxillary sinus, ACC should be included in the differential diagnosis of lesions affecting this site.

Bárbara Vanessa de Brito, Monteiro; Rafael Grotta, Grempel; Daliana Queiroga de Castro, Gomes; Gustavo Pina, Godoy; Márcia Cristina da Costa, Miguel.

2014-04-01

90

Adenoid cystic carcinoma: a comparative pathologic study of tumors in salivary gland, breast, lung, and cervix.  

Science.gov (United States)

Histologic, histochemical, and ultrastructural features of eight adenoid cystic carcinomas arising at diverse sites were compared in order to determine diagnostic values and to investigate histogenetic mechanisms. These tumors originated in the salivary glands, breast, uterine cervix, and tracheobronchial tree. By light microscopy each tumor was seen to have morphologic features of adenoid cystic carcinoma, yet only five of the eight cases showed differential staining for the two mucin types, stromal and epithelial, which are reportedly present in these tumors. In contrast, every case showed a set of fine structural features which, in aggregate, are specific for adenoid cystic carcinoma. These features include pseudocysts, intercellular spaces, basal lamina, and true glandular lumens. The most prominent feature is the pseudocyst, which mimics a glandular lumen by light microscopy but is actually a rounded extracellular space containing basal lamina. Ultrastructurally, the variation in composition of the extracellular compartments, including pseudocysts and true lumens, appears to explain the lack of uniformity in the histochemical staining. The tumors also contained cytoplasmic microfilaments in parallel bundles, consistent with myofilaments. The presence of these filaments combined with basal lamina suggests myoepithelial differentiation, yet it is not known whether these tumors truly originate from myoepithelium or show differentiation toward myoepithelium as a part of the neoplastic process. Regardless of their histogenesis, this study shows that true adenoid cystic carcinomas do arise in different organs. Knowledge of the specific ultrastructural features of adenoid cystic carcinomas can be useful in classifying these tumors in some cases. PMID:6290368

Lawrence, J B; Mazur, M T

1982-10-01

91

Adenoid cystic carcinoma of the lacrimal gland metastasising to the liver: report of a case  

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Full Text Available Abstract Background Adenoid Cystic Carcinoma of the lacrimal gland is a rare tumour. Their aggressive behaviour, with a high-risk of local recurrence, and late distant spread of the tumour even after aggressive management has been reported. Metastasis to the liver is rare and when it occurs, it is usually part of widespread metastasis, and therefore surgical treatment is seldom considered. Case presentation We report a rare case of an isolated liver metastasis from a lacrimal gland adenoid cystic carcinoma 20 years after resection of the primary tumour. The patient presented with right upper quadrant pain radiating to the back and shortness of breath of 3 months duration. No local recurrence was detected during a 15 year follow-up with computerized tomography (CT of the head. Abdominal CT scan demonstrated a solitary liver tumour with no other primary source, and the bone scan was normal. The patient was treated with an extended right hemihepatectomy. The histology revealed a predominantly cribriform tumour with focal areas of basaloid type metastatic lacrimal gland adenoid cystic carcinoma. Conclusion This case illustrates the unpredictable behaviour of adenoid cystic carcinoma and the need for a life long follow up for these patients after treatment. The possibility of surgical resection for liver metastasis from adenoid cystic carcinoma should always be considered.

Pearce Neil W

2006-09-01

92

Radiologic evaluation of adenoids and tonsils in children with obstructive sleep apnea: Plain films and fluoroscopy  

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Twenty-six children with obstructive sleep apnea were evaluated by lateral neck radiographs during wakefulness, and by polygraphic monitoring and upper airway fluoreoscopy during natural sleep. Children with craniofacial abnormalities, palatal surgery, and central nervous system disease were excluded from the study. Moderate or marked enlargement of tonsils and adenoids was noted on lateral neck radiographs of 18 of 26 patients. An objective measure of adenoidal enlargement, the adenoidal-nasopharyngeal ratio, correlated well with subjective judgment of adenoidal size but was not generally more useful than subjective estimation. Upper airway fluroescopy demonstrated the site and mechanism of obstruction in all patients. Because all children with moderate to marked adenotonsillar enlargement demonstrated obstruction at the adenoidal or tonsillar level on fluoroscopy, we now screen children with suspected sleep apnea with lateral airway radiographs and polysomnography. Fluoroscopy is reserved for children with mild adenotosillar enlargement, craniofacial dysplasia, prior cleft palate repair, or neuromuscular disorders. These results suggest that the pathogenesis of obstuctive sleep apnea in children involve anatomic factors which narrow the upper airway, sleep-related hypotonia of pharyngeal dilator musculature, and compensatory mechanisms to prevent or alleviate asphyxia.

Kreplick Fernbach, S.; Brouillette, T.; Riggs, T.W.; Hunt, C.E.

1983-07-01

93

The value of radiological examination in the management of adenoidal hypertrophy in a pediatric population  

International Nuclear Information System (INIS)

The objective of this study is to evaluate the role of radiological examination in the management of adenoidal hypertrophy. A retrospective study was carried out in the North West Armed Forces Hospital, Tabuk, Kingdom of Saudi Arabia on pediatric patients who had x-ray of lateral nasopharynx to exclude adenoidal hypertrophy, January 2001 to December 2001. The study included ; the age of patient, sex and reason for radiology examination and management rendered. A total of two hundred and ninety- seven pediatric patients were involved. Two hundred and thirteen males (71.7%) and 84(28.3%) females, age ranged between 2 months and 12 years. The reason given for radiological examination was one or more of following symptoms snoring,mouth breathing recurrent tonsillitis, runny nose, deafness and obstructive sleep apnea.Small adenoids reported in 63 patients (21.2%)and were treated for their complaints by primary physician. Two hundred and thirty four patients (78.8%) with large adenoids were referred to the otolaryngology department of these 33 patients lost follow up. One hundred and nineteen referred(40.1%) patients were treated conservatively, while 82 patients (27.6%) who showed resistance to medical treatment under went adeniodectomy with or without other related surgical procedures. It was concluded that radiological examination in the management of adenoidal hypertrophy had a limited role, increased Radiological Department workload wastage of resources in addition to kload wastage of resources in addition to unnecessary radiation exposure. (author)

94

Radiologic evaluation of adenoids and tonsils in children with obstructive sleep apnea: Plain films and fluoroscopy  

International Nuclear Information System (INIS)

Twenty-six children with obstructive sleep apnea were evaluated by lateral neck radiographs during wakefulness, and by polygraphic monitoring and upper airway fluoreoscopy during natural sleep. Children with craniofacial abnormalities, palatal surgery, and central nervous system disease were excluded from the study. Moderate or marked enlargement of tonsils and adenoids was noted on lateral neck radiographs of 18 of 26 patients. An objective measure of adenoidal enlargement, the adenoidal-nasopharyngeal ratio, correlated well with subjective judgment of adenoidal size but was not generally more useful than subjective estimation. Upper airway fluroescopy demonstrated the site and mechanism of obstruction in all patients. Because all children with moderate to marked adenotonsillar enlargement demonstrated obstruction at the adenoidal or tonsillar level on fluoroscopy, we now screen children with suspected sleep apnea with lateral airway radiographs and polysomnography. Fluoroscopy is reserved for children with mild adenotosillar enlargement, craniofacial dysplasia, prior cleft palate repair, or neuromuscular disorders. These results suggest that the pathogenesis of obstuctive sleep apnea in children involve anatomic factors which narrow the upper airway, sleep-related hypotonia of pharyngeal dilator musculature, and compensatory mechanisms to prevent or alleviate asphyxia. (orig.)

95

Supraglottic adenoid cystic carcinoma mimicking laryngeal amyloidosis: A case report.  

Science.gov (United States)

Supraglottic adenoid cystic carcinoma (ACC) is extremely rare and may be misdiagnosed as laryngeal amyloidosis. The present report describes a case of supraglottic ACC, which went unrecognized until histopathological examination of the neoplasm 18 months after the first presentation. The present patient presented with progressive hoarseness for half a year and initially required partial resection. Following quick regional recurrence, the patient received a total laryngectomy while refusing radiotherapy. Adjuvant post-operational traditional Chinese medicine was accepted. Over 3 years' follow-up, there was no evidence of regional relapse or distant metastases. The present case is compared with a second case of supraglottic submucosal mass in which the signs, symptoms and examinations were similar to the first case, but that was diagnosed as laryngeal amyloidosis. Attention should be paid to submucosal masses in the larynx to prevent underlying malignancy and subsequent disease progression. Immunocytochemistry, such as p63 staining, is mandatory for making an early differential diagnosis of supraglottic ACC. Traditional Chinese medicine may be a useful adjuvant therapy for this rare disease. PMID:24932306

Qian, Xiaoyun; Zhou, Han; Gu, Yajun; Zhang, Yifen; Gao, Xia

2014-06-01

96

Conservative treatment of adenoid cystic carcinoma with plaque radiotherapy: a case report.  

Science.gov (United States)

Adenoid cystic carcinoma is a rare but aggressive malignant tumor of the lacrimal gland. Mortality rates have been found to be quite high (>50%). This has led to the traditional method of treatment with radical surgery including orbital exenteration and bone resection, followed by external beam radiotherapy to the orbital bed. Despite this aggressive treatment strategy, mortality rates still remain high with only a few reported cases with long-term survival. Recently, several cases of successful treatment of adenoid cystic carcinoma with plaque radiotherapy have been documented. These may show promise of a conservative treatment strategy in selected cases. The authors present a functionally monocular patient with a well-circumscribed adenoid cystic carcinoma that was treated with local excision of the tumor with reverse plaque brachytherapy "boost" to the lacrimal tumor bed followed by a lower dose of radiotherapy to the orbit. The patient is alive and without local recurrence at nearly 4 years. PMID:20305520

Lewis, Kyle T; Kim, Daniel; Chan, Wayne F; Jaiwatana, Jaisari; Calcote, Clay

2010-01-01

97

Pitfalls in magnetic resonance imaging of adenoid cystic carcinoma of the airways  

International Nuclear Information System (INIS)

Involvement of the airways by adenoid cystic carcinoma is best evaluated with multiple sequences of MRI in various planes, as long as the interpreting physician is aware of the potential pitfalls. Adenoid cystic carcinoma (cylindroma) of the airways is an uncommon malignancy which can be treated with positive results by surgery and radiation therapy. Pre-therapeutic assessment is important in determining the extent of local tumor invasion and the involvement of mediastinal structures, especially if surgery is proposed as part of the therapy. A case of adenoid cystic carcinoma of the airways with multi-planar MRI in multiple sequences is presented, together with a discussion of the pitfalls of chemical shift artifact in the distal trachea. (orig.)

98

Primary adenoid cystic carcinoma of the esophagus. Report of a case and review of the literature.  

Science.gov (United States)

A case of primary adenoid cystic carcinoma of the esophagus is reported and a total of 15 cases was reviewed. There were 9 men, although earlier reports indicated the disease was more common in women. The lesion was located in the middle third of the esophagus in 10 cases. The possibility of tumor development from embryonal rests of the tracheobronchial tree in the esophagus is discussed. The prognosis of adenoid cystic carcinomas is not well known, but the treatment and prognosis appear similar to those of epidermoid carcinomas of the esophagus. PMID:165333

Pourzand, A; Freant, L; Levin, R; Peabody, J; Absolon, K

1975-05-01

99

Muco-epidermoid and adenoid cystic carcinomas of the tracheobronchial tree.  

Science.gov (United States)

Muco-epidermoid and adenoid cystic carcinomas of the respiratory tree are uncommon and warrant attention because of controversy and uncertainty surrounding their behaviour and management. Ten cases of these tumours are detailed, with emphasis on approach to management. Careful attention should be paid to histological grading of muco-epidermoid carcinomas. Low grade tumours, completely excised, behave the best. Adenoid cystic carcinomas are slow-growing, relentlessly progressive tumours and difficult to eradicate locally. Surgery remains the best therapeutic tool available. PMID:1850979

Chetty, R; Forder, M D; De Groot, M; Bowden, G

1991-05-01

100

Adenoid Type of Basal Cell Carcinoma: Rare Histopathological Variant at an Unusual Location  

OpenAIRE

Basal Cell Carcinoma (BCC) is almost exclusively seen in head-neck region with rare involvement of trunk and extremities. The tumour is commonly seen on nose, eyelids, at the inner canthus of eyes and behind the ears. Adenoid type of BCC is one of the rare histopathological types of BCC which has not found to have any site predilection. We report two cases of BCC occurring at an unusual site i.e., lower back and both of them showed adenoid type of BCC on histopathology. Morphologically they w...

Tambe, Swagata A.; Ghate, Smita S.; Jerajani, Hemangi R.

2013-01-01

101

Adenoid cystic carcinoma of the external auditory canal: Report of two cases  

Directory of Open Access Journals (Sweden)

Full Text Available Adenoid cystic carcinoma occurring in the external auditory canal is very rare. Two cases are being reported. One was diagnosed on cytology based on which surgery was planned. In the second case, fine needle aspiration procedure had to be abandoned due to severe pain and a biopsy was required for its diagnosis. Morphologically, it resembles its more common salivary gland counterpart. Though severe pain during needling may be a limiting factor, adenoid cystic carcinoma of external auditory canal can be confidently diagnosed on cytology based on which surgical management can be planned.

Nayak Supreeta

2009-10-01

102

Adenoid cystic carcinoma of the external auditory canal: report of two cases.  

Science.gov (United States)

Adenoid cystic carcinoma occurring in the external auditory canal is very rare. Two cases are being reported. One was diagnosed on cytology based on which surgery was planned. In the second case, fine needle aspiration procedure had to be abandoned due to severe pain and a biopsy was required for its diagnosis. Morphologically, it resembles its more common salivary gland counterpart. Though severe pain during needling may be a limiting factor, adenoid cystic carcinoma of external auditory canal can be confidently diagnosed on cytology based on which surgical management can be planned. PMID:19805967

Nayak, Supreeta P; Walke, Vaishali A; Helwatkar, Satish B; Bobhate, Sudhakar K

2009-01-01

103

Nasofaringoscopia flexible como instrumento diagnóstico en pacientes con adenoiditis crónica  

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Full Text Available Antecedentes: la hipertrofia adenoidea es una causa común de obstrucción nasal en la población pediátrica. La evaluación adenoidea en niños puede resultar difícil; tradicionalmente se ha utilizado la valoración clínica como método ideal y el diagnóstico se corrobora con una radiografía lateral de cráneo. Con la introducción de la nasofaringoscopia flexible, se ha evaluado a un gran número de niños sin exponerlos a la radiación. Objetivo: comparar la eficacia de la nasofibroscopia flexible vs la radiografía lateral de cráneo en el diagnóstico de adenoiditis. Material y métodos: se hizo un estudio retrospectivo, observacional, abierto y transversal en un centro de atención terciario. Resultados: se evaluaron 179 pacientes pediátricos de 2 a 14 años de edad, divididos en tre grupos, haciendo una equivalencia entre lo reportado en la radiografía lateral de cráneo y en la nasofaringoscopia flexible. La edad de mayor incidencia correspondió al intervalo de cuatro a ocho años, con 96 casos. Los síntomas más frecuentes fueron: respiración oral con 89% y rinolalia con 82%. El análisis estadístico se realizó con prueba exacta de Fisher, y se encontró una p < 0.002, con un intervalo de confianza de 95%. Mediante tablas de contingencia de 2 x 2 se determinó una sensibilidad de 95% para la nasofaringoscopia flexible y de 65% para la radiografía lateral de cráneo. Conclusión: la nasofaringoscopia flexible tiene mayor confiabilidad en la corroboración diagnóstica de la hipertrofia adenoidea que la radiografía lateral de cráneo; además, acorta el tiempo de conclusión terapéutica al demostrar en ese momento las obstrucciones objetivas del tejido adenoideo.

Mariana Dur\\u00E1n Ortiz

2012-01-01

104

Métastase musculaire d'un carcinome épidermoide du col utérin: à propos d'un cas avec revue de la littérature  

Science.gov (United States)

Les métastases musculaires sont rares, leur nombre est probablement sous estimé. Nous rapportons le cas d'une patiente âgée de 65 ans, ayant présenté une métastase musculaire d'un carcinome épidermoïde du col utérin 6 mois après le diagnostic de la tumeur primitive. Le diagnostic a été obtenu à partir de la biopsie et du scanner abdomino-pelvien. Le traitement a consisté en une irradiation palliative à la dose de 30Gy. L’évolution a été marquée par le décès de la patiente. A travers ce cas clinique on a démontré que le muscle peut être touché par les métastases d'un carcinome épidermoïde du col utérin et que leur pronostic reste en général péjoratif. PMID:25368712

Mezouri, Imane; Chenna, Hanane; Bellefqih, Sara; ElKacemi, Hanan; Kebdani, Tayeb; Benjaafar, Noureddine

2014-01-01

105

Analysis of MYB expression and MYB-NFIB gene fusions in adenoid cystic carcinoma and other salivary neoplasms.  

Science.gov (United States)

Recent studies have shown that the recurrent t(6;9)(q22-23;p23-24) translocation in adenoid cystic carcinoma results in a novel fusion of the MYB proto-oncogene with the transcription factor gene NFIB. To determine the frequency of this finding, we used RT-PCR assays of the MYB and MYB-NFIB fusion transcripts, and immunohistochemistry for the MYB protein, to study adenoid cystic carcinomas and other epithelial tumors of the salivary glands, and head and neck region. MYB-NFIB fusion transcript was detected in 25 of 29 (86%) frozen adenoid cystic carcinoma tumor samples, and in 14 of 32 (44%) formalin-fixed paraffin-embedded adenoid cystic carcinoma tumor specimens. In contrast, the MYB-NFIB fusion was not expressed in non-adenoid cystic carcinoma neoplasms of the head and neck, confirming the high specificity of the MYB-NFIB fusion. Adenoid cystic carcinomas from various anatomic sites, including salivary gland, sinonasal cavity, tracheobronchial tree, larynx, breast, and vulva were repeatedly fusion-positive, indicating that adenoid cystic carcinomas located in different anatomic sites not only have important morphologic features in common, but also probably evolve through activation of the same molecular pathways. Studies of the expression of MYB revealed that 89% of the tumors, including both fusion-positive and fusion-negative cases, overexpressed MYB RNA. Similarly, 82% of adenoid cystic carcinomas stained positive for MYB protein, compared with 14% of non-adenoid cystic carcinoma neoplasms, indicating that MYB immunostaining may be useful for the diagnosis of adenoid cystic carcinoma, but that neoplasms sometimes in the differential diagnosis are also labeled. The latter are, however, fusion-negative. In summary, our studies show that MYB activation through gene fusion or other mechanisms is a major oncogenic event in adenoid cystic carcinoma occurring at various anatomic sites. In addition to being a diagnostically useful biomarker for adenoid cystic carcinoma, MYB and its downstream effectors are also novel potential therapeutic targets. PMID:21572406

Brill, Louis B; Kanner, William A; Fehr, André; Andrén, Ywonne; Moskaluk, Christopher A; Löning, Thomas; Stenman, Göran; Frierson, Henry F

2011-09-01

106

Identification of c-kit gene mutations in primary adenoid cystic carcinoma of the salivary gland.  

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The CD117 (KIT) protein is overexpressed in many human neoplasms including adenoid cystic carcinoma of salivary glands. To evaluate the function of c-kit-activating mutations in adenoid cystic carcinoma of the salivary gland, we studied 14 cases (13 primary, 1 cervical lymph node metastasis) from our institution. KIT protein expression was evaluated by immunohistochemistry using formalin-fixed paraffin-embedded tissue. Mutational analyses of c-kit extracellular (exon 9), juxtamembrane (exon 11) and tyrosine kinase domains (exons 13 and 17) were performed by polymerase chain reaction, clonal selection and DNA sequencing. All 14 cases demonstrated strong KIT expression by immunohistochemistry. Molecular analysis was successful in 8 of 14 cases, and c-kit missense point mutations were detected in seven of eight cases (88%) including seven in exon 11, two in exon 9, two in exon 13 and two in exon 17. Eight silent point mutations were detected in five cases. Two cases contained missense mutations in more than one exon. Different mutations were found in the primary tumor and the cervical lymph node metastasis of one patient. Point mutations in domains similar to those described in gastrointestinal stromal tumors were detected, including Pro551Leu and Lys558Glu (5' end of exon 11), Leu576Phe (3' end of exon 11), Val643Ala (exon 13) and Asn822Ser (exon 17). Additional novel point mutations in exons 9, 11, 13 and 17 were also identified. This study is the first to report c-kit gene mutations in primary adenoid cystic carcinoma of the salivary gland. Identification of such potential gain-of-function mutations in exon 11, and less frequently in exons 9, 13 and 17, suggests that KIT may be involved in the pathogenesis of adenoid cystic carcinoma of salivary glands. Our study raises a prospect of correlation of c-kit mutation and a potential treatment of adenoid cystic carcinoma with tyrosine kinase inhibitor (imatinib). PMID:19617878

Vila, Lizette; Liu, Hongyan; Al-Quran, Samer Z; Coco, Dominique P; Dong, Hui-Jia; Liu, Chen

2009-10-01

107

Adenoid cystic carcinoma of the head and neck: A retrospective series of 169 cases  

International Nuclear Information System (INIS)

Purpose. - Adenoid cystic carcinoma represents 1% of head and neck cancers. Adenoid cystic carcinomas are slow growing tumours with high potential for local recurrence. Treatment usually associates radiotherapy and surgery, but the role of radiotherapy remains unclear. We report a retrospective multicentric study of the management and prognostic factors of 169 adenoid cystic carcinomas of head and neck. Patients and methods. - Between 1982 and 2010, 169 patients with adenoid cystic carcinoma of the head and neck were referred to the Cercle des oncologues radiotherapeutes du Sud departments of radiotherapy either for primary untreated tumour (n = 135) or for a recurrence of previously treated tumour (n = 34). The site of adenoid cystic carcinoma was: parotid gland (n = 48, 28.4%), minor salivary gland (n = 35, 20.7%), submandibular gland (n = 22, 13%), sinus cavities (n = 22, 13%), other (n = 42, 24.9%). Tumour stages were: T1 (12.4%); T2 (14.2%); T3 (12.4%); T4 (41.4%) and Tx (19.5%). Lymph node involvement was 13% and distant metastasis 8.9%. For adenoid cystic carcinomas of the parotid gland, major nerve involvement was evaluated. Preferential site of metastasis was the lung (87.5%). Treatments were: surgery alone (n = 27), surgery and adjuvant radiotherapy (n = 89), surgery and adjuvant chemoradiotherapy (n 12), exclusive chemoradiotherapy (n = 13), exclusive radiotherapy (n = 14), other associations (n = 5) and no treatment (n = 7). Radiotherapy was delivered throt (n = 7). Radiotherapy was delivered through photons (n = 119), neutrons (n = 6), both (n = 4). Two patients had a brachytherapy boost. Median prescribed doses to T and N were respectively 65 Gy and 50 Gy for the 119 photons treated patients. Results. - Mean follow-up was 58 months (range 1-250 months). As of December 1, 2010, 83 patients were alive with no evolutive disease (49%), 35 alive and had recurred, 18 had uncontrolled evolutive disease, 28 had died of adenoid cystic carcinoma and 5 of intercurrent disease. Overall survival and disease free survival were respectively 72% and 72% at 5 years, 53% and 32% at 10 years; 5 and 10-year freedom from local recurrence were 81% and 52% respectively. Nerve involvement was found in 17/48 parotid gland adenoid cystic carcinomas. The Cox model including all patients, showed that surgery (P < 0.001), surgical margins (P = 0.015), nerve involvement (P = 0.0079), length of radiotherapy (P = 0.018), and tumour location (P = 0.041) were associated with disease free survival. Conclusion. - In this large series of adenoid cystic carcinoma of head and neck with a majority of T3-T4 tumours, 10-year survivals were achieved for 50% of patients. Radiotherapy did not impact survival. (authors)

108

A rare case of adenoid cystic carcinoma of the nasopharynx manifesting as Horner’ s syndrome: discussion and review of the literature  

OpenAIRE

Adenoid cystic carcinoma is a malignant tumour involving the salivary glands, rarely developing in the nasopharynx. The biological behaviour of adenoid cystic carcinoma is characterized by slow growth rate, high tendency to local recurrence and metastatic spread. Its histological features are particularly important for prognostic prediction: solid pattern has the worst outcome. Initial presentation of nasopharyngeal adenoid cystic carcinoma with paresis of cranial nerves and Horner’ s syndr...

Soprani, F.; Armaroli, V.; Venturini, A.; Emiliani, E.; Casolino, D.

2007-01-01

109

[A clinical study of resected adenoid cystic carcinoma of the tracheobronchial tree].  

Science.gov (United States)

From 1973 to 1990, 7 patients presented with a adenoid cystic carcinoma of tracheobronchial tree that was treated surgically. The locations were larger airways; 4 in the trachea, 1 in the carina, 2 in the basal bronchus. Surgical treatments were performed in all cases. The following resections were done: trachea only 3; carina 1; trachea plus larynx 1; left lower lobe (sleeve lobectomy) 1; left lung (pneumonectomy) 1. Except for tracheolaryngectomy and left pneumonectomy, all cases were undergone primary anastomosis. Operative death was only one patient who died of anastomotic separation. Irradiation was performed in 6 patients before or after operation. Two patients were died due to lung metastases or leukemia. According to the Kaplan-Meier's method, the 5 years survival rate of all patients was 68.6%. Our experience suggests that surgical treatment and adjunctive radiotherapy is beneficial in patients with adenoid cystic carcinoma. PMID:8382327

Andou, A; Shimizu, N; Okabe, K; Date, H; Teramoto, S

1993-02-01

110

Detection of atypical metastases in recurrent adenoid cystic carcinoma of parotid gland.  

Science.gov (United States)

We report a known case of adenoid cystic carcinoma of right parotid gland in a 36-year-old Indian male, diagnosed 5 years ago for which he underwent surgery followed by radiotherapy. Now the patient has presented to the surgical oncologist with a mass near angle of right jaw. Computed tomography (CT) performed elsewhere was reported negative for local recurrence. Subsequently, 18 F Fluorodeoxyglucose positron emission tomography-CT (FDG PET-CT) demonstrated local recurrence in right parotid bed. Surprisingly, metabolically active metastatic skeletal deposits were also identified, thus the disease was upstaged and management was changed. Trucut biopsy from left iliac bone lesion confirmed metastases from adenoid cystic carcinoma. Thus a whole body PET-CT has a significant impact on management of patients with salivary gland malignancies in assessing both local recurrence as well as distant metastases, especially in atypical and unsuspected sites. PMID:23575100

Tewari, Anshu; Padma, Subramanyam; Sundaram, Palaniswamy Shanmuga

2013-01-01

111

Cytodiagnosis of intracranial metastatic adenoid cystic carcinoma: Spread from a primary tumor in the lacrimal gland  

OpenAIRE

Adenoid cystic carcinoma (ACC) of the lacrimal gland is a rarely encountered orbital tumor. It invades intracranially more frequently than carcinomas of other glands in the head and neck. A 61-year-old man underwent right orbital exenteration for a tumor in the supraorbital region. He had lost all records and presented to us with a diffuse swelling in the right forehead, six years later. Fine-needle aspiration cytology of the right frontal swelling revealed monomorphic population of small, sl...

Mardi, Kavita; Kaushal, Vijay; Uppal, Hari

2011-01-01

112

Adenoid cystic carcinoma of the lacrimal gland metastasising to the liver: report of a case  

OpenAIRE

Abstract Background Adenoid Cystic Carcinoma of the lacrimal gland is a rare tumour. Their aggressive behaviour, with a high-risk of local recurrence, and late distant spread of the tumour even after aggressive management has been reported. Metastasis to the liver is rare and when it occurs, it is usually part of widespread metastasis, and therefore surgical treatment is seldom considered. Case presentation We report a rare case of an isolated liver metastasis f...

Pearce Neil W; El-Mahallawi Hanan; Al-Gholmy Mohammed; Hilal Mohammed Abu; Zeidan Bashar A; Primrose John N

2006-01-01

113

Skull Base Invasion of Adenoid Cystic Carcinoma of the Lacrimal Gland : A Case Report  

OpenAIRE

Although adenoid cystic carcinoma (ACC) of the lacrimal gland is a rarely encountered orbital tumor, it invades intracranially more frequently than carcinomas of other glands in the head and neck. A 52-year-old man underwent orbital exenteration and resection of intracranially extended tumor via a fronto-orbito-zygomatic approach in combination with a transfacial approach. Histopathologically, the tumor showed perineural, vascular, and lymphatic invasion. Additionally, he received radiotherap...

Lee, Jae Il; Kim, Young Zoon; Lee, Eun Hee; Kim, Kyu Hong

2008-01-01

114

Life-Threatening Obstructive Sleep Apnea Caused by Adenoid Hypertrophy in an Infant with Noonan Syndrome  

OpenAIRE

Adenoidectomy is a commonly performed surgery in children, even though its effectiveness is still under investigation. However, in children with risk factors such as age under 3 years old, associated comorbidities, or severe obstructive sleep apneas, a high postoperative respiratory morbidity is possible. We report the case of a 15-month-old boy with Noonan syndrome and a complex clinical history, who presented with a life-threatening obstructive sleep apnea due to hypertrophy of the adenoids...

Sonia Khirani; Nicolas Leboulanger; Adriana Ramirez; Brigitte Fauroux

2012-01-01

115

Tuberculous granuloma and adenoid cystic carcinoma presenting as a single buccal space mass.  

Science.gov (United States)

We report an unusual case of a 58-year-old man with a "collision lesion" of the buccal space. Initially diagnosed as tuberculoma, the patient showed only partial response to an extensive course of antibiotics, prompting more vigorous investigation. This revealed the presence of a concomitant malignancy, specifically adenoid cystic carcinoma. Definitive treatment was then achieved by surgical resection and flap reconstruction with postoperative radiation therapy. PMID:12140418

Landa, Leopoldo E; Kathju, Sandeep; Nepomuceno-Perez, Mia C; Gordon, Christopher; Sotereanos, George C

2002-07-01

116

Primary pulmonary adenoid cystic carcinoma diagnosed by transthoracic fine needle aspiration cytology  

Directory of Open Access Journals (Sweden)

Full Text Available Adenoid cystic carcinoma (ACC is an uncommon tumor that very rarely affects the lower respiratory tract and lung parenchyma. Fine needle aspiration cytology (FNAC of primary pulmonary ACC has been rarely described. We report here a 32 year-old female with peripheral ACC, diagnosed by percutaneous transthoracic FNAC. The cytological diagnosis was further confirmed by histological examination of the biopsy specimen.

Nuwal Paras

2008-01-01

117

Adenoid cystic carcinoma of the external auditory canal: correlation between histological features and MRI appearances.  

Science.gov (United States)

A rare case of adenoid cystic carcinoma of the external auditory canal with magnetic resonance imaging appearances is reported. Both T1 weighted and T2 weighted MR images showed the tumour as a hypointense mass, although there was marked contrast enhancement. Microscopic examination of the resected tumour showed a preponderance of solid tumour cell nests. According to previous reports, these pathological and radiological findings indicate a poor prognosis. PMID:9227237

Aikawa, H; Tomonari, K; Okino, Y; Hori, F; Ueyama, T; Suenaga, S; Bundo, J; Tsuji, K

1997-05-01

118

Adenoid cystic carcinoma of the base of the tongue: Late metastasis to the pancreas  

OpenAIRE

Adenoid cystic carcinoma (ACC) is a relatively rare epithelial tumor of the salivary glands. We present a 64-year-old gentleman with ACC of the tongue who following resection and radiotherapy, presented 10 years later with a lung metastasis and underwent operative intervention and further radiotherapy. Five years later he presented with obstructive jaundice found to be metastatic ACC. We believe this to be the first report of an ACC metastasizing to the pancreas.

Falk, Gavin A.; El-hayek, Kevin; Morris-stiff, Gareth; Tuthill, Ralph J.; Winans, Charles G.

2011-01-01

119

Aggressive Adenoid Cystic Carcinoma With Asymptomatic Spinal Cord Compression Revealed By A “Curtain Sign”  

OpenAIRE

The authors present a case of unusually aggressive adenoid cystic carcinoma of the head and neck. The patient presented with sciatica one year after initial diagnosis. She was otherwise asymptomatic. Complete work-up for bone involvement, included bone scan and MRI. The patient had painful osteolytic sacral metastasis and asymptomatic thoracic (T5) vertebral metastasis revealed by a typical curtain sign on MRI. The curtain sign, originally described by Trolard, is due to the displacement of t...

Martin Housset; Pierre-Yves Marcy; Cécile Badoual; Fournier, Laure S.; Juliette Thariat

2008-01-01

120

Estrogen and Progesterone Receptor and p53 Gene Expression in Adenoid Cystic Cancer  

OpenAIRE

Objectives The current study examined the role of estrogen receptors (ER), progesterone receptors (PR) and p53 expression in adenoid cystic carcinoma (ACC) to determine if simple expression or possible overexpression of these products might influence the development and natural course of this cancer. Study Design ER and PR status and p53 overexpression were retrospectively evaluated utilizing immunohistochemical evaluation of 47 ACC specimens. Methods Formalin-fixed paraffin-embedded tissues ...

Barrera, Jose E.; Shroyer, Kenneth R.; Said, Sherif; Hoernig, George; Melrose, Raymond; Freedman, Paul D.; Wright, Tanya A.; Greer, Robert O.

2007-01-01

121

Adenoid cystic carcinoma of the breast with cerebral metastisation: a clinical novelty.  

Science.gov (United States)

Adenoid cystic carcinoma (ACC) is a rare variant of adenocarcinoma of the breast. It affects mainly minor and major salivary glands, but may also occur in many others locations such as: breast (multiple and fatal metastisation pattern-nodal, pulmonary, hepatic, osseous and late multifocal cerebral involvement (brain stem and cerebellum). This is the first case-report of ACC with cerebral metastisation. PMID:22679170

Silva, Ines; Tome, Vera; Oliveira, Joao

2011-01-01

122

Nasopharyngeal adenoid cystic carcinoma: a case report and review of the literature  

OpenAIRE

ACC derived from nasopharyngeal epithelial cells is rare, usually benign. In this article, we reported a nasopharyngeal adenoid cystic carcinoma (NACC) in a 31-year-old woman with a symptom of hoarseness, headache, epistaxis slightly, diplopia, facial numbness and dysphagia near 3 months. A tumor on the right side of the nasopharynx was confirmed by laryngoscope check and MRI of the skull base. Histopathological findings showed that tumor cells were arranged in cord-like or acinar-like by aty...

Liang, Yan-fang; Kong, Bin; Xiang, Wen-yu; Ruan, Jian-bo; Wang, Ling-mei; Chen, Can; Xu, Wei-hua; Wu, Qiu-liang; Zeng, Jin-cheng; Xu, Jun-fa

2014-01-01

123

Adenoid cystic carcinoma of the esophagus: report of two cases and review of the Chinese literature  

OpenAIRE

Abstract Squamous cell carcinoma is the major pathology type of esophageal cancer in China, where adenocarcinoma is rare and adenoid cystic carcinoma (ACC) is more rare comparing to the western countries. We report the surgical and pathologic findings of two cases of primary ACC of the esophagus, and review of the Chinese literature of this tumor. Virtual slides The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/15075...

Guo Xu-feng; Mao Ten; Gu Zhi-tao; Fang Wen-tao; Chen Wen-hu; Shao Jin-chen

2012-01-01

124

Sinonasal Adenoid Cystic Carcinoma: Clinical Case Report and Literature Review / Carcinoma Adenoide Quístico Nasosinusal: Caso Clínico y Revisión de la Literatura  

Scientific Electronic Library Online (English)

Full Text Available SciELO Chile | Language: English Abstract in spanish Se presenta el caso de un paciente de sexo masculino de 59 años con carcinoma adenoide quístico nasosinusal. El examen de resonancia magnética reveló la invasión de la órbita derecha y el cerebro a nivel del suelo de la fosa craneal anterior. Debido al gran volumen, se decidió realizar el tratamient [...] o de radio-quimioterapia para disminuir el tamaño de la lesión. Al término de la primera etapa del tratamiento, la reducción del tamaño del tumor fue confirmada por el examen de tomografía computarizada y se decidió realizar una resección quirúrgica con preservación del globo ocular derecho. En la actualidad el paciente se encuentra bajo el control periódico y sin mayores complicaciones. Abstract in english We present the case of a patient, a 59 year-old man, with Sinonasal Adenoid Cystic Carcinoma. Magnetic resonance exam revealed invasion of the right orbit and brain at the level of the anterior cranial fossa floor. Due to the large volume, we decided to perform radio-chemotherapy treatment to dimini [...] sh the size of the lesion. On conclusion of the first stage of treatment, reduction in tumor size was confirmed by computerized tomography exam and we decided to perform surgical resection with right ocular globe preservation. At present the patient is under periodic control and without major complications.

Ilson, Sepúlveda; Carolina, Delgado; Paulo, Flores; Ornella, Salvatori.

125

Métastase musculaire d'un carcinome épidermoide du col utérin: à propos d'un cas avec revue de la littérature  

OpenAIRE

Les métastases musculaires sont rares, leur nombre est probablement sous estimé. Nous rapportons le cas d'une patiente âgée de 65 ans, ayant présenté une métastase musculaire d'un carcinome épidermoïde du col utérin 6 mois après le diagnostic de la tumeur primitive. Le diagnostic a été obtenu à partir de la biopsie et du scanner abdomino-pelvien. Le traitement a consisté en une irradiation palliative à la dose de 30Gy. L’évolution a été marquée par le décès de la patie...

Mezouri, Imane; Chenna, Hanane; Bellefqih, Sara; Elkacemi, Hanan; Kebdani, Tayeb; Benjaafar, Noureddine

2014-01-01

126

Association rare d'un adenome pleomorphe et d'un carcinome epithelial myoepithelial de la glande parotide  

Science.gov (United States)

Le Carcinome épithélial - myoépithélial (CEM) est une tumeur maligne rare des glandes salivaires touchant principalement la glande parotide. Son association avec un adénome pléomorphe est exceptionnelle. Nous rapportons le cas d'une femme de 57 ans avec adénome pléomorphe de la glande parotide évoluant depuis plusieurs années. L'augmentation récente du volume de la glande associée à l'apparition d'adénopathies cervicales homolatérales nous a fait penser à une transformation maligne. L'examen histologique final après parotidectomie totale a montré une association inattendue d'un adénome pléomorphe et un CEM. Le CEM est une tumeur maligne de bas grade. Elle peut survenir de novo ou sur un adénome pléomorphe. La transformation maligne de l'adénome est suspectée devant l'augmentation rapide du volume de l'adénome avec apparition d'adénopathies cervicales. Toutefois, ces modifications cliniques peuvent annoncer l'apparition d'une tumeur distincte. Malgré sa tendance à la récidive locale et un faible potentiel métastatique, de rares cas de CEM peuvent avoir un comportement agressif et des métastases à distance. Le traitement consiste principalement en une résection chirurgicale complète si possible suivie d'une radiothérapie dans le but de prévenir la récidive locale. PMID:25368716

Jahidi, Ali; Hemmaoui, Bouchaib; Noureddine, Errami; Youssef, Darouassi; Issam, Rharrasi; Hafsa, Chahdi; Benariba, Fouad

2014-01-01

127

Long-term local control of recurrent adenoid cystic carcinoma in the parotid gland with radiotherapy and intraarterial infusion chemotherapy.  

Science.gov (United States)

We report a case of postoperative recurrence of adenoid cystic carcinoma in the left parotid gland treated with radiotherapy and arterial infusion chemotherapy. A 52-year-old woman had a history of surgical resection for an adenoid cystic carcinoma arising from the left parotid gland 25 years before. Despite two reoperations for local recurrence after the initial surgery, she had a third local recurrence in the remnant of the left parotid gland. The patient was treated with a concurrent combination of radiotherapy (60 Gy/30F) and intraarterial infusion chemotherapy with carboplatin (750 mg/30 days) from which she obtained a complete response. The patient has remained free of local progression 54 months after treatment. Radiotherapy and arterial infusion chemotherapy is effective treatment for local recurrence of adenoid cystic carcinoma in the head and neck. PMID:16958403

Terashima, Koutarou; Shioyama, Yoshiyuki; Nakamura, Katsumasa; Ohga, Saiji; Nomoto, Satoshi; Yamaguchi, Toshihiro; Toba, Takashi; Yoshitake, Tadamasa; Yabuuchi, Hidetake; Nakashima, Torahiko; Terashima, Hiromi; Honda, Hiroshi

2006-05-01

128

Imaging appearance of a singular metastatic adenoid cystic carcinoma of the right kidney: A case report and literature review.  

Science.gov (United States)

Renal metastasis of a submandibular gland adenoid cystic carcinoma is clinically rare when it presents with an atypical imaging appearance of singular renal metastases. Whole-body positron emission tomography (PET)/computed tomography (CT) can determine whether the singular renal mass is benign or malignant and identify metastases in other parts of the body, particularly in uncommon sites. In the present case, the patient developed a rare partial metastasis to the right kidney three years after undergoing a surgery for submandibular gland adenoid cystic carcinoma. Based on the present case, whole-body PET/CT examination could provide an important basis for making treatment plans for singular renal metastases. PMID:25364446

Qiu, DA-Sheng; Xu, Li-Ying; Hu, Xiao-Yan

2014-12-01

129

Adenoid cystic carcinoma presenting as an ulcer on the floor of the mouth: a rare case report  

Science.gov (United States)

Adenoid cystic carcinoma is a rare epithelial tumour, and comprises about 1% of all malignant tumours of the oral and maxillofacial region. It is a malignant tumour which may develop in the trachea, bronchus, lungs or mammary glands, in addition to the head and neck region. Occurrences in the head and neck are mostly detected in the major salivary gland, oral cavity, pharynx and paranasal sinus where it presents as a slow growing firm nodular swelling. The aim of the article is to highlight the unique presentation of adenoid cystic carcinoma as a solitary ulcer on the floor of the mouth. PMID:25368840

Agwani, Khalid; Bhargava, Puneet; Kumar, Sreeja P.

2014-01-01

130

Translocation t(6;14) as the Sole Chromosomal Abnormality in Adenoid Cystic Carcinoma of the Base of Tongue  

OpenAIRE

We present an adenoid cystic carcinoma of the base of tongue in a 48-year-old male with a restricted chromosomal alteration by cytogenetic and spectral karyotypic analysis (SKY). SKY and G-banding analyses identified the t(6;14)(q25;q13) as the sole structural aberration in all metaphases analyzed. This finding supports a critical role for this event in the development of this tumor. The implications of chromosome 6q translocation in this case and in previously reported adenoid cystic carcino...

Bell, Diana; Zhao, Yi-jue; Rao, Pulivarthi H.; Weber, Randal S.; El-naggar, Adel K.

2007-01-01

131

Polymorphous low-grade adenocarcinoma of the vulva and vagina: a tumor resembling adenoid cystic carcinoma.  

Science.gov (United States)

We report the first case of a polymorphous low-grade adenocarcinoma (PLGA) occurring in the vulva and vagina of a 32-year-old woman. This tumor consisted of cellular lobules with distinct cribriform, papillary, and cystic patterns. Owing to its location and its distinct cribriform pattern, this lesion was initially diagnosed as an unusual variant of adenoid cystic carcinoma (ACC). However, this diagnosis was revised to PLGA when it was recognized that the cribriform, papillary and cystic patterns and their concomitant occurrence in the same lesion are characteristic of PLGA. PLGA should be added to the differential diagnosis of vulvar and vaginal neoplasia. PMID:12598921

Young, Stephanie; Leon, Marino; Talerman, Aleksander; Teresi, Maria; Emmadi, Rajysree

2003-01-01

132

[Adenoid cystic carcinoma of the lacrimal gland in a 14-year-old girl].  

Science.gov (United States)

The discovery of unilateral exophthalmia requires multidisciplinary care made all the more difficult in the case of a 14-year-old girl living in a tropical environment. The child, C.A., resident of the town of Djenné in Mali, was examined for nonpulsate, nonretractile, left lateral unilateral exophthalmia, painful upon palpation of a left upper-external mass under the orbital rim. The initial examination highlighted the existence of an intraorbital tumor with a moderate effect on visual function. In view of the slow and progressive development over 2 years, and with the assistance of an association, the child was transferred to a specialized medical structure where the tumorous nature was confirmed after surgical exeresis. The diagnosis was cylindroma, or adenoid cystic carcinoma. Neither chemotherapy nor radiation were used. At 15 months after surgery, the child showed no clinical sign of recurrence. Intraorbital tumors in children present diagnostic and therapeutic problems in countries with limited medical resources. Cylindromas or adenoid cystic carcinomas of the lachrymal gland are the second most common cause of epithelial tumors in this gland, which are characterized by a high degree of malignancy, a very high rate of recurrence, and a low survival rate at 5 years. In a tropical environment, diagnostic and therapeutic difficulties are compounded by limits to comprehensive care for the child. PMID:17075512

Boitte, J-P; Traoré, J; Boukhet, F; Mondié, J-M; Traoré, M; Delbosc, B

2006-10-01

133

Clinicopathological study of 54 cases of adenoid cystic carcinoma in the head and neck  

Energy Technology Data Exchange (ETDEWEB)

A retrospective analysis was performed on 54 patients with adenoid cystic carcinoma in the head and neck, treated from January 1971 to July l997 in the Kurume University Hospital. The patients consisted of 35 females and 19 males, with a mean age of 59 years. The site of the lesion was the oral cavity in 13, nasal cavity in 11, submandibular gland in 8, parotid gland in 5, paranasal sinus in 3, nasopharynx in 3, oropharynx in 3, external auditory canal in 3, orbita in 2, lip in 1, lacrimal gland in 1 and trachea in 1. The over all 5-year, 10-year and 15-year survival rates as determined by the Kaplan-Meier method were 72%, 53%, and 46%, respectively. There was no relationship between survival rate and the site of the original lesion. According to the histologic criteria reported by Szanto et al., when more than 30% of the neoplasma showed a solid pattern, its treatment outcome appeared poor. In this study, the same tendency was seen. Fifteen patients died of the tumor. Ten died of distant metastasis and 5 died of local recurrence invading the cranium. No patient died of neck metastasis. Adenoid cystic carcinoma was thought to be radioresistant, but recently some authors have reported this tumor as radiosensitive. This study also showed that postoperative radiotherapy was effective, producing an increase in the survival rate. (author)

Umeno, Hirohito; Miyajima, Yoshimi; Mori, Kazunori; Nakashima, Tadashi [Kurume Univ., Fukuoka (Japan). School of Medicine

1997-12-01

134

Clinicopathological study of 54 cases of adenoid cystic carcinoma in the head and neck  

International Nuclear Information System (INIS)

A retrospective analysis was performed on 54 patients with adenoid cystic carcinoma in the head and neck, treated from January 1971 to July l997 in the Kurume University Hospital. The patients consisted of 35 females and 19 males, with a mean age of 59 years. The site of the lesion was the oral cavity in 13, nasal cavity in 11, submandibular gland in 8, parotid gland in 5, paranasal sinus in 3, nasopharynx in 3, oropharynx in 3, external auditory canal in 3, orbita in 2, lip in 1, lacrimal gland in 1 and trachea in 1. The over all 5-year, 10-year and 15-year survival rates as determined by the Kaplan-Meier method were 72%, 53%, and 46%, respectively. There was no relationship between survival rate and the site of the original lesion. According to the histologic criteria reported by Szanto et al., when more than 30% of the neoplasma showed a solid pattern, its treatment outcome appeared poor. In this study, the same tendency was seen. Fifteen patients died of the tumor. Ten died of distant metastasis and 5 died of local recurrence invading the cranium. No patient died of neck metastasis. Adenoid cystic carcinoma was thought to be radioresistant, but recently some authors have reported this tumor as radiosensitive. This study also showed that postoperative radiotherapy was effective, producing an increase in the survival rate. (author)

135

Adenoid Cystic Carcinoma: A Review of Recent Advances, Molecular Targets and Clinical Trials.  

Science.gov (United States)

Purpose: Adenoid cystic carcinoma (ACC) is a rare tumor of secretory glands. Recent advances in molecular characterization and in therapeutics are reviewed. Design: A search of articles in Pubmed and of abstracts from national meetings was performed. Results: Recent genetic analyses find that recurrent chromosome 6:9 translocations in ACC generate a MYB:NFIB fusion resulting in overexpression of the MYB oncoprotein. Several other frequent mutations are recently published which may be relevant for drug development. Several trials of targeted drugs are reviewed. Some agents delay tumor progression, but tumor responses remain rare. Conclusions: Adenoid cystic carcinomas have a characteristic chromosomal translocation, but also frequently pick up additional mutations. Clinical research is limited by the rarity of ACC and slow growth of ACC. Several ongoing trials are testing agents that inhibit fibroblast growth factor receptor signaling or other signaling pathways. Novel treatments based on the recently sequenced tumor genome are under development. This article is protected by copyright. All rights reserved. PMID:25487882

Dillon, Patrick M; Chakraborty, Samhita; Moskaluk, Christopher A; Joshi, Prashant J; Thomas, Christopher Y

2014-12-01

136

Reactive Oxygen Species and Autophagy Associated Apoptosis and Limitation of Clonogenic Survival Induced by Zoledronic Acid in Salivary Adenoid Cystic Carcinoma Cell Line SACC-83  

OpenAIRE

Salivary adenoid cystic carcinoma is an epithelial tumor in the head and neck region. Despite its slow growth, patients with salivary adenoid cystic carcinoma exhibit poor long term survival because of a high rate of distant metastasis. Lung and bone are common distant metastasis sites. Zoledronic acid, a third generation bisphosphonate, has been used for tumor-induced osteolysis due to bone metastasis and has direct antitumor activity in several human neoplasms. Here, we observed that zoledr...

Ge, Xi-yuan; Yang, Lin-qian; Jiang, Yang; Yang, Wen-wen; Fu, Jia; Li, Sheng-lin

2014-01-01

137

Bilateral Testicular Metastases of Adenoid Cystic Variant of Carcinoma of Prostate  

Directory of Open Access Journals (Sweden)

Full Text Available Prostate cancer is the second most frequently diagnosed cancer in men (13.6% and the fifth most common cancer globally. Common sites of prostate carcinoma metastasis other than lymph nodes, include bones, lungs, urinary bladder, liver and adrenal glands. Rarely, a testicular mass, whether painful or painless, represents a metastasis. Metastasis in testes accounts for 0.06-2.5%. Bilateral testicular metastasis is less common and occurs in about 15% of cases. We report a case of prostatic adenocarcinoma in a 65 year male with metastasis to both testes identified upon histopathological examination of therapeutic orchidectomy specimen. Unusual adenoid cystic pattern seen in the metastatic deposits is highlighted. Bilateral metastasis is extremely rare and few are reported in literature

Anita AM,

2014-07-01

138

Adenoid cystic carcinoma of the tracheobronchial system. The role of postoperative radiotherapy  

Energy Technology Data Exchange (ETDEWEB)

To clarify the role of postoperative radiotherapy for adenoid cystic carcinoma of the tracheobronchial system (ACC), we analyzed patients treated at the National Cancer Center Hospital, Tokyo. Seven patients with ACC were treated with resective surgery and postoperative radiotherapy from 1962-1990. None of the primary lesions was completely surgically resected. Postoperative irradiation was delivered by standard fractionation at a dose range of 49.2-72 Gy. Four of seven patients lived more than 5 years, up to 21 years, without local recurrence. In contrast, three other patients who showed recurrence within 2 years died of disease before 5 years. Three of four patients who received postoperative irradiation of 60 Gy or more attained local control. One of three patients who received less than 60 Gy failed locally. A high dose of postoperative radiotherapy for patients with a positive surgical margin of ACC seems to improve local control and result in long-term survival. (author).

Ogino, Takashi; Shimizu, Wakako [National Cancer Center, Chiba (Japan). Hospital East; Ono, Ryousuke; Ikeda, Hiroshi

1995-01-01

139

Adenoid cystic carcinoma of the tracheobronchial system: the role of postoperative radiotherapy.  

Science.gov (United States)

To clarify the role of postoperative radiotherapy for adenoid cystic carcinoma of the tracheobronchial system (ACC), we analyzed patients treated at the National Cancer Center Hospital, Tokyo. Seven patients with ACC were treated with resective surgery and postoperative radiotherapy from 1962-1990. None of the primary lesions was completely surgically resected. Postoperative irradiation was delivered by standard fractionation at a dose range of 49.2-72 Gy. Four of seven patients lived more than 5 years, up to 21 years, without local recurrence. In contrast, three other patients who showed recurrence within 2 years died of disease before 5 years. Three of four patients who received postoperative irradiation of 60 Gy or more attained local control. One of three patients who received less than 60 Gy failed locally. A high dose of postoperative radiotherapy for patients with a positive surgical margin of ACC seems to improve local control and result in long-term survival. PMID:7597201

Ogino, T; Ono, R; Shimizu, W; Ikeda, H

1995-01-01

140

Adenoid cystic carcinoma of the tracheobronchial system. The role of postoperative radiotherapy  

International Nuclear Information System (INIS)

To clarify the role of postoperative radiotherapy for adenoid cystic carcinoma of the tracheobronchial system (ACC), we analyzed patients treated at the National Cancer Center Hospital, Tokyo. Seven patients with ACC were treated with resective surgery and postoperative radiotherapy from 1962-1990. None of the primary lesions was completely surgically resected. Postoperative irradiation was delivered by standard fractionation at a dose range of 49.2-72 Gy. Four of seven patients lived more than 5 years, up to 21 years, without local recurrence. In contrast, three other patients who showed recurrence within 2 years died of disease before 5 years. Three of four patients who received postoperative irradiation of 60 Gy or more attained local control. One of three patients who received less than 60 Gy failed locally. A high dose of postoperative radiotherapy for patients with a positive surgical margin of ACC seems to improve local control and result in long-term survival. (author)

141

Clinicopathological study of surgically treated cases of tracheobronchial adenoid cystic carcinoma.  

Science.gov (United States)

Between 1980 and 2007, five patients were pathologically diagnosed as tracheobronchial adenoid cystic carcinoma (ACC). All five patients were women aged 37-67 years. Four tumors were located in the larger airways, and one tumor was located in the peripheral lung. The following operations were done: bronchoplastic procedures in three (carinal resection with doublebarreled carinoplasty in one, sleeve right pneumonectomy in one, sleeve middle lobectomy in one), left pneumonectomy in one, and left upper lobectomy in one. Three of the five patients have survived for 172, 144, and 10 months after surgery, respectively. The best local treatment for ACC of the major airway is considered to be sleeve resection of the trachea or bronchus in an area where airway reconstruction may not be disturbed and to add postoperative irradiation when there is residual carcinoma at the stump. However, it seems controversial to recommend adjuvant radiotherapy in all patients undergoing resection. PMID:20155344

Shimizu, Junzo; Oda, Makoto; Matsumoto, Isao; Arano, Yoshihiko; Ishikawa, Norihiko; Minato, Hiroshi

2010-02-01

142

Skull base invasion of adenoid cystic carcinoma of the lacrimal gland : a case report.  

Science.gov (United States)

Although adenoid cystic carcinoma (ACC) of the lacrimal gland is a rarely encountered orbital tumor, it invades intracranially more frequently than carcinomas of other glands in the head and neck. A 52-year-old man underwent orbital exenteration and resection of intracranially extended tumor via a fronto-orbito-zygomatic approach in combination with a transfacial approach. Histopathologically, the tumor showed perineural, vascular, and lymphatic invasion. Additionally, he received radiotherapy (60 Gy) and adjuvant systemic cisplatin and 5-fluorouracil chemotherapy due to residual tumor in the orbit and systemic metastases (lung, ribs, and spines). He was free of progression and recurrence at 6 months after treatment. The authors report a case of skull base invasion by an ACC of the lacrimal gland to remind neurosurgeons planning intervention that this disease shows a tendency to invade intracranially. PMID:19096692

Lee, Jae Il; Kim, Young Zoon; Lee, Eun Hee; Kim, Kyu Hong

2008-10-01

143

Skull base tumor invading both cavernous sinuses. Adenoid cystic carcinoma mimicking a meningioma.  

Science.gov (United States)

We present a case of an anterior skull base tumor invading both cavernous sinuses and extending into the right orbit in a 55 years old female. The radiological aspect was confusing, being highly suggestive for an extensively invasive meningioma. However, the orbital portion of the tumor, which was surgically removed, proved to be an adenoid cystic carcinoma. Some peculiar immunohistochemical findings were obvious, as well as a lack of continuity of the tumor with the local lacrimal gland. This is an unusual situation, when a lacrimal gland tumor spread along the cavernous sinus, cross the midline and approaches the contralateral orbit. Such local extension should be considered in the differential diagnosis of anterior skull base tumors. PMID:17392985

Arsene, D; Ardeleanu, Carmen; D?n?il?, L

2006-01-01

144

Adenoid cystic carcinoma in the maxillary gingiva: a case report and immunohistochemical study  

Directory of Open Access Journals (Sweden)

Full Text Available Gingival adenoid cystic carcinoma (ACC is a rare malignancy. We describe the diagnosis and treatment of a 43 year-old woman who presented with a persistent oral ulcer for approximately 1 year, and subsequent pain in the left posterior maxillary region. Clinical examination revealed an ulcer in the left upper molar gingiva, with swelling in the region from the second premolar to the third molar. X-ray images demonstrated the involvement of the maxillary alveolar bone. The histopathological and immunohistochemical features were diagnostic of ACC. ACC is often presented as a gingival lesion; thus, it may easily be neglected by patients. The identification of this tumor using specific pathological analyses prevents misdiagnosis and enables clinicians to determine the appropriate treatment. In this case, no recurrence or distant metastasis was observed after 2 years of follow-up.

Chi Zhao

2013-03-01

145

Nasopharyngeal adenoid cystic carcinoma: a case report and review of the literature.  

Science.gov (United States)

ACC derived from nasopharyngeal epithelial cells is rare, usually benign. In this article, we reported a nasopharyngeal adenoid cystic carcinoma (NACC) in a 31-year-old woman with a symptom of hoarseness, headache, epistaxis slightly, diplopia, facial numbness and dysphagia near 3 months. A tumor on the right side of the nasopharynx was confirmed by laryngoscope check and MRI of the skull base. Histopathological findings showed that tumor cells were arranged in cord-like or acinar-like by atypical hyperplastic epithelial cells forming a cribriform and tubular pattern, and immunohistochemical findings showed that tumor tissues were immunopositive for p63 (+), CK7 (+), CK19 (+), CK8 (+), CK18 (+), SMA (+), CK (+), p53 (++), S-100 (+) and Ki-67 (5%+), and negative for CD34 (-), CK5/6 (-), CEA (-) and CD117 (-). Patient was treated by surgical operation and radiotherapy, and was followed-up near 10 months, no local recurrence and distant metastasis. PMID:25120845

Liang, Yan-Fang; Kong, Bin; Xiang, Wen-Yu; Ruan, Jian-Bo; Wang, Ling-Mei; Chen, Can; Xu, Wei-Hua; Wu, Qiu-Liang; Zeng, Jin-Cheng; Xu, Jun-Fa

2014-01-01

146

Adenoid cystic carcinoma of the breast: A case report and literature review  

Science.gov (United States)

Adenoid cystic carcinoma (ACC) is a rare malignant tumor of the breast that occurs in Trabzon, Turkey) with complaints of pain in the upper outer quadrant of the right breast. An excision biopsy of a lump in the upper outer quadrant revealed ACC, and perineural invasion was present. Subsequently, the patient underwent breast conservation surgery and sentinel lymph node dissection. Pathology from the second surgery depicted ACC in the form of microscopic foci around the initial surgical cavity, with two reactive sentinel lymph nodes and the closest negative margin at 2 mm. The patient was treated with radiotherapy following the surgery. No recurrence and metastasis were found after 20 months of follow-up. In conclusion, mammary ACC is a rare malignant neoplasm of the breast. Although surgery is the main treatment, the optimal adjuvant treatment of ACC of the breast has not yet been determined due to its low incidence. PMID:24765184

CANYILMAZ, EMINE; USLU, GONCA HANEDAN; MEM??, YAHYAHAN; BAHAT, ZÜMRÜT; YILDIZ, KADRIYE; YONEY, ADNAN

2014-01-01

147

Outcomes and Prognostic Variables in Adenoid Cystic Carcinoma of the Head and Neck: A Recent Experience  

International Nuclear Information System (INIS)

Purpose: To analyze the recent experience of patients with adenoid cystic carcinoma treated with radiation therapy at Memorial Sloan-Kettering Cancer Center. Methods and Materials: From 1990 to 2004, a total of 59 patients with a diagnosis of primary adenoid cystic carcinoma of the head and neck received radiation therapy at our institution. The subsite distribution was oral cavity, 28% (n = 17); paranasal sinuses, 22% (n = 13); parotid, 14% (n = 8); submandibular, 14% (n = 8); oropharynx, 10% (n = 6); sublingual, 3% (n = 2); nasopharynx, 3% (n = 2); and other, 5% (n = 3). T Stage distribution was T1, 34% (n = 20); T2, 19% (n = 11); T3, 14% (n = 8); and T4, 34% (n = 20). Twenty-nine percent of patients (n = 17) were treated with intensity-modulated radiation therapy; 25% (n =15), with three-dimensional conformal therapy, and the remainder, with conventional techniques. Ninety percent (n = 53) of patients received treatment including the base of skull. Results: Median follow-up for surviving patients was 5.9 years. Five-year and 10-year rates of local control and distant metastases-free survival were 91%/81% and 81%/49%, respectively. Five-year and 10-year rates of disease-free and overall survival were 76%/40% and 87%/65%, respectively. On univariate analysis, stage T4 (p = 0.004) and gross/clinical nerve involvement (p = 0.002) were associated with decreased progression free survival, whereas stage T4 and lymph node involvement were associated with decreased overall nt were associated with decreased overall survival (p = 0.046 and p < 0.001, respectively). Conclusions: Radiation therapy in combination with surgery produces excellent rates of local control, although distant metastases account for a high proportion of failures. Routine treatment to the base of skull reduces the significance of histologic perineural invasion, but major nerve involvement remains an adverse prognostic factor

148

Adenoid cystic carcinoma of the parotid gland: Anastamosis of the facial nerve with the great auricular nerve after radical parotidectomy  

OpenAIRE

Adenoid cystic carcinoma of the parotid gland is a rare and slowly growing, but highly malignant tumor. Surgical resection of a malignant parotid tumor should include resection of the facial nerve when the nerve is involved in the tumor. Facial nerve reconstruction is required after nerve resection. A 14 year-old female presented with complaints of painless enlargement of the right parotid gland and facial asymmetry. Physical examination revealed a firm mass in the region of the parotid gland...

Bahadir Osman; Livaoglu Murat; Ural Ahmet

2008-01-01

149

Pigmented adenoid cystic carcinoma of the ear skin arising from the epidermis: a case report with immunohistochemical studies  

OpenAIRE

Adenoid cystic carcinoma (ACC) in the skin is very rare; only about 60 cases have been reported. Herein presented is a case of pigmented ACC arising from epidermis of the ear skin. An 85-year-old man presented black tumor of the right ear. Dermatologists’ diagnosis was basal cell carcinoma (BCC). Large biopsy was obtained. The biopsy showed proliferation of atypical basaloid cells arranged in a cribriform pattern. The tumor cells were continuous with epidermis, as if it arose from the epide...

Terada, Tadashi

2012-01-01

150

Simultaneous diagnosis of ipsilateral adenoid cystic carcinoma of the lacrimal gland and orbital cavernous hemangioma: case report.  

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To describe a patient with coexistence of ipsilateral adenoid cystic carcinoma of the lacrimal gland and orbital cavernous hemangioma. The patient presented a 2-month history of painful swelling of left upper eyelid, which did not resolve on a course of oral steroid. On clinical examination, she had moderate medial and inferior dislocation of the eye globe, edema of the temporal superior eyelid and moderate restriction upgaze. Magnetic resonance imaging identified two left orbital tumors: one was a lesion that arose from the lacrimal gland, and the second was a well-defined, ovoid, intraconal mass. The patient underwent lateral orbitotomy and excision of both lesions. Postoperative histological features demonstrated two different lesions: an adenoid cystic carcinoma of the lacrimal gland and a cavernous hemangioma. The clinical presentation of the present case was strongly suggestive of a lacrimal gland malignancy, although the imaging features did not show typical invasive aspects. This is the first report of coexistence of lacrimal gland adenoid cystic carcinoma and cavernous hemangioma in the ipsilateral orbit. PMID:24786224

Strianese, Diego; Ferrara, Mariantonia; Iuliano, Adriana; Bonavolontà, Giulio

2014-08-01

151

Detection of Respiratory Viruses in Nasopharyngeal Swab and Adenoid Tissue from Children Submitted to Adenoidectomy: Pre- and Postoperative Analysis  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in english Introduction The presence of respiratory viruses in lymphoid tissues of the nasopharynx and oropharynx and its impact on recurrent infections and hypertrophy of these tissues are not yet fully understood. Objective To identify and determine the prevalence of major respiratory viruses in nasopha [...] ryngeal secretions and adenoid tissue pre- and postoperatively of children undergoing adenoidectomy. Methods A prospective observational study was conducted in 36 patients under 12 years of age with upper airway lymphoid hypertrophy who were undergoing adenoidectomy, in which various respiratory viruses were investigated using real-time polymerase chain reaction in adenoid tissue and nasopharyngeal secretions collected preoperatively and 30 days postoperatively. Results At least 1 viral agent was isolated in any of the samples collected in 58.3% of children and 25.9% of total samples. Respiratory viruses were identified in 33.8% of preoperative nasopharyngeal specimens and in 19.8% of postoperative secretion. Of the 21 patients with positive results for any respiratory virus, 6 (28.6%) had more than 1 virus. Considering all 36 respiratory viruses found, the main agent isolated was rhinovirus (27.8%), followed by bocavirus (22.2%). Conclusion The virus found more frequently in all samples was rhinovirus. After removal of adenoid tissue, there was a decrease in the prevalence of the virus contained in nasopharyngeal secretion 30 days after surgery.

Osvaldo Vinícius, Biill Primo; Edmir Américo, Lourenço; Saulo Duarte, Passos.

2014-04-01

152

Elective Neck Dissection in Patients With Head and Neck Adenoid Cystic Carcinoma : An International Collaborative Study  

DEFF Research Database (Denmark)

BACKGROUND: Adenoid cystic carcinoma (ACC) accounts for 3-5 % of all head and neck malignancies. Investigations of outcomes from elective neck dissection (END) for patients with ACC are sparse. This study aimed to assess the impact of END on the survival of patients with ACC. METHODS: This retrospective multicentered study investigated 270 patients who underwent neck dissection. A multivariate analysis assessed associations of clinical and histopathologic characteristics with survival outcomes. RESULTS: The primary tumor sites included the oral cavity in 250 patients (55 %), the major salivary glands in 133 patients (29 %), the sinonasal mucosa in 68 patients (15 %), and the larynx in six patients (1 %). The overall rate of occult nodal metastases among the patients who underwent END was 17 % (38/226). The highest incidence of occult nodal metastases was with the oral cavity (66 %). The 5-year overall survival (72 and 79 % for patients with or without END, respectively) and disease-specific survival (74 and81 % for patients with or without END, respectively) were similar in the two groups. The subgroup analysis of patients according to the primary site showed no significant impact of END on outcome. In the multivariate analysis, primary site, T classification, and N classification were the only variables associated with outcome. CONCLUSIONS: The incidence of occult neck metastases among patients with ACC is 17 %. The highest incidence of occult metastases is with the oral cavity. Statistical analysis showed no survival advantage for patients who underwent END compared with those who did not.

Amit, Moran; Na'ara, Shorook

2014-01-01

153

Fine-needle aspiration diagnosis of high grade adenoid cystic carcinoma metastatic to the pancreas.  

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Pancreatic tumors are mostly primary tumors, with only rare metastatic tumors described in the literature. Here we report an unusual case of fine-needle aspiration (FNA) diagnosis of high grade adenoid cystic carcinoma of the parotid gland metastatic to the pancreas. The aspirate smears were moderately cellular and revealed numerous basaloid neoplastic cells. The cytomorphologic differential diagnosis included primary pancreatic tumor with small cell morphology as well as metastatic tumors. By immunocytochemistry, the tumor cells were positive for cytokeratins (AE1/AE3, CAM5.2, and CK7), and CD117 (C-KIT), and negative for CD45, WT1, synaptophysin, chromogranin, CD56, TTF-1, and CK20. The cytomorphologic features and immunoprofile in our case were consistent with high-grade carcinoma metastases from patient's known salivary gland primary. To the best of our knowledge, this case is the first reported encounter of FNA diagnosis of pancreatic metastasis with small cell morphology from a salivary gland neoplasm as primary site. Diagn. Cytopathol. 2015;43:117-120. © 2014 Wiley Periodicals, Inc. PMID:24554389

David, Doina; Masineni, Sreeharsha N; Giorgadze, Tamar

2015-02-01

154

Clinicopathological features of salivary and non-salivary adenoid cystic carcinomas.  

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Adenoid cystic carcinoma (ACC), commonly from salivary glands, is known for its insidious local growth and usually protracted clinical course. ACC developing from non-salivary glands (i.e., non-salivary ACC) is heterogeneous, and its clinicopathological features remain poorly defined. Patients treated for ACC in a single institution between 1995 and 2007 were included in this study. Immunohistochemical evaluation of Ki-67, E-cadherin, p16, and cyclinD1 was performed. The prognostic significance of clinical and immunophenotypic markers was evaluated. 83 cases of salivary ACC and 24 cases of non-salivary ACC were included. The expression levels of Ki-67 (54.8%), E-cadherin (90.4%), p16 (32.9%), and cyclinD1 (19.2%) between ACCs present at various sites were not different. Sinonasal, lacrimal, and tracheobronchial ACCs had significantly worse outcomes than those of ACC of the major salivary glands. Postoperative radiotherapy reduced the recurrence rate of patients with a negative resection margin (P=0.028). Older age (age >60 years), advanced stage, positive resection margin, high histological grade, and high expression of Ki-67 were significantly correlated with poor prognosis. In conclusion, the site of origin plays a role in the prognosis of ACC, in which positive resection margin and advanced stage are possible factors underlying the differences in outcomes. PMID:22230288

Lin, Yu-Chin; Chen, Ko-Chin; Lin, Ching-Hung; Kuo, Kuan-Ting; Ko, Jeng-Yuh; Hong, Ruey-Long

2012-03-01

155

Cytodiagnosis of intracranial metastatic adenoid cystic carcinoma: Spread from a primary tumor in the lacrimal gland.  

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Adenoid cystic carcinoma (ACC) of the lacrimal gland is a rarely encountered orbital tumor. It invades intracranially more frequently than carcinomas of other glands in the head and neck. A 61-year-old man underwent right orbital exenteration for a tumor in the supraorbital region. He had lost all records and presented to us with a diffuse swelling in the right forehead, six years later. Fine-needle aspiration cytology of the right frontal swelling revealed monomorphic population of small, slightly atypical cells, arranged in multilayered groups with abundant fine intercellular metachromatic substance between cell groups. There were hyaline globules of varying size with attached tumor cells. Cytological diagnosis of metastatic intracranial ACC with a lacrimal gland primary was suggested. Biopsy of the swelling confirmed our cytological diagnosis of ACC with perineural, vascular and lymphatic invasion. Thus, the authors report this case of intracranial metastasis of ACC of the lacrimal gland to remind neurosurgeons planning intervention that this disease shows a tendency to invade intracranially. PMID:22090696

Mardi, Kavita; Kaushal, Vijay; Uppal, Hari

2011-10-01

156

Long-Term Outcomes of Neoadjuvant Intraarterial Cytoreductive Chemotherapy for Lacrimal Gland Adenoid Cystic Carcinoma  

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Purpose To compare the long-term outcomes after intraarterial cytoreductive chemotherapy (IACC) to conventional treatment for lacrimal gland adenoid cystic carcinoma (ACC). Design Retrospective case series. Participants Nineteen consecutive patients treated with IACC, followed by orbital exenteration, chemoradiotherapy, and intravenous chemotherapy. Interventions Analyses of the histologic characteristics of biopsy specimens, extent of disease at the time of diagnosis, diagnostic surgical procedures, incidence of locoregional recurrences or distant metastases, disease-free survival time, response to IACC, tumor margins at definitive surgery, and toxicity and complications. Main Outcome Measures Disease relapse, disease-free survival, and chemotherapeutic complications. Results Eight patients with an intact lacrimal artery had significantly better outcomes for survival (100% vs. 28.6% at 10 years), cause-specific mortality, and recurrences (all p=0.002, log-rank test) than conventionally treated patients from this institution. These eight patients (Group 1) had cumulative 10 year disease-free survival of 100% compared to 50% for 11 patients (Group 2) who had an absence of the lacrimal artery and/or deviated from the treatment protocol (p=0.035) and 14.3% for conventionally treated patients (placrimal artery, no disruption of bone barrier or tumor manipulation other than incisional biopsy, and protocol compliance are factors responsible for favorable outcomes. The chemotoxicity complication rate is limited and manageable. PMID:23582989

Tse, David T.; Kossler, Andrea L.; Feuer, William J.; Benedetto, Pasquale W.

2013-01-01

157

Multiple cutaneous metastases: a rare and late sequelae of lacrimal gland adenoid cystic carcinoma.  

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Primary cutaneous adenoid cystic carcinoma (ACC) is an uncommon malignancy with approximately 60 cases reported in the literature. Metastatic ACC to the skin is even less frequent with eight previously published cases, including only one arising from the lacrimal gland. We report a case of a 61-year-old male, who developed multiple cutaneous metastases to the scalp and back from a lacrimal gland ACC 21 years after the initial diagnosis. Initially, in the absence of the past clinical history, the cutaneous lesions were interpreted as primary ACC of the skin. Histopathologically, the metastatic lesions were poorly circumscribed dermal and subcutaneous nodules that were composed of islands of basaloid epithelial cells with ducts and cribriform pattern, mucinous stroma and prominent perineural invasion. Histomorphologically, the cutaneous tumors were similar to the primary ACC. The cutaneous metastases were preceded by tumor dissemination to the lung and other visceral organs, and ultimately led to patient's demise. This report illustrates the importance of juditious clinico-pathologic correlation and raises awareness regarding prolonged latency of cutaneous metastases in patients with visceral ACC. PMID:23899266

Jedrych, Jaroslaw; Galan, Anjela

2013-03-01

158

Adenoid Cystic Carcinoma of the Trachea: a Report of Seven Cases and Literature Review  

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Full Text Available Background: Adenoid cystic carcinoma (ACC of the trachea is rare. The clinical manifestations,natural history, and responses to therapy differ from those of othermalignant tracheal tumors.Method: In this retrospective study, we examined pathological records of patients inthe Department of Pathology at Chang Gung Memorial Hospital from 1990through 2002. There were five male patients and two female patients withages that ranged from 21 to 55 years. For these seven patients the clinicalmanifestations and period from initial symptoms to diagnosis, treatment andoutcome are presented.Results: Hemoptysis, nonproductive cough, dyspnea, chest pain and weight loss werethe frequent early manifestations. Five patients had tumors in the lower areaof the trachea, two had tumors in the upper area of the trachea. In a patientwith the tumor in the upper area of the trachea, the tumor involved thecricoid ring, larynx, and subglottic area. In one patient with the tumor in thelower area of the trachea, the tumor invaded the right lower lobe of the lung.The longest survival time was more than 10 years.Conclusions: ACC is a rare primary tracheal malignancy. The time from first symptoms todiagnosis varied, ranging from weeks to more than 1 year. Complete surgicalresection provides the patient with the best chance of prolonged survival oreven complete remission.

Po-Yi Yang

2005-05-01

159

[Oro-pharyngeal burn during electrodissection of the adenoid and tonsil].  

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We present a case of oro-pharyngeal burn which occurred during electrodissection of the adenoid and tonsil in a 5-year-old boy. We intubated the patient with an uncuffed spiral tube of appropriate size and noticed a slight gas leak during positive-pressure ventilation. Anesthesia was maintained with a mixture of 60% nitrous oxide, 40% oxygen and 2.5% sevoflurane. During manipulations of the right tonsil, orange-colored flame blew out about 5 cm from the mouth. Fortunately, the patient underwent the operative procedures without any further troubles, recovered fully from the grade 1 burn in the oral mucosa, and was discharged 23 days after surgery. The surgeons speculated that sevoflurane had been ignited. Although it is well known that sevoflurane is nonflammable in the concentration of clinical use, several reports show that sevoflurane is flammable in concentration of 10% under pure oxygen or nitrous oxide. We concluded that this accident was caused by electrocautery-induced ignition of the gauze packed into the larynx under a high concentration of oxygen which leaked through an uncuffed endotracheal tube. We have to bear in mind that any flammable substance may ignite when using electrocautery in a small space such as the mouth under oxygen-rich environment. PMID:9251513

Tsuchida, M; Sakuma, K; Maruyama, M; Hanazawa, H; Urano, M; Shimoji, K

1997-07-01

160

Intracranial extension of adenoid cystic carcinoma of the palate: a case report  

International Nuclear Information System (INIS)

Intracranial involvement by adenoid cystic carcinoma (ACC) is very rare and there is no report of intracranial extension from the palate ACC in Korea. Intracranial involvement can occur in one of three ways: direct extension, perineural spread, and hematogenous spread. A case report of a 35-year-old woman with intracranial ACC is presented. Initially she had ACC of the right palate and was treated by surgery and postoperative radiation therapy. Three years and 10 months later, the paresthesia in the distribution of ophthalmic and maxillary branch of right trigeminal nerve developed without evidence of recurrence in CT scan. Ptosis and total ophthalmoplegia developed sequentially and the second operation was performed. It was suggested that the tumor was spread perineurally along the trigeminal nerve into the Gasserian ganglion and then cavernous sinus and orbit. Seven years and 6 months after the first operation, direct intracranial extension into the right temporal lobe developed via sphenoid bone, sphenoid sinus and temporal bone and the third operation was done. And then Jung metastasis was diagnosed. She is alive for 9 years 5 months after first operation

161

Evaluation of a German version of the tonsil and adenoid health status instrument.  

Science.gov (United States)

BackgroundTo create and validate a German version of the Tonsil and Adenoid Health Status Instrument (TAHSI) for evaluation of tonsillectomy outcome in adult patients with chronic or recurrent tonsillitis.Subjects and methods46 healthy volunteers were assessed twice in a 6 week interval with the TAHSI questionnaire. Their results were compared with 45 patients suffering from chronic tonsillitis before tonsillectomy and 6 months following surgery. For internal consistency, Cronbach¿s alpha was calculated; to identify normal score values, the optimum cutoff between healthy and diseased individuals was identified with receiver operating characteristic analysis; and responsiveness was assessed using Guyatt¿s Responsiveness Index (GRI).ResultsCronbach¿s alpha for all questions was 0.92. Test- retest intraclass correlation coefficient was 0.89 (95% confidence interval 0.80-0.94 p¿<¿0.001). Mean score for the healthy individuals was 7.0 (95% confidence interval 4.2-9.7). The optimum cut off score between healthy and diseased was 20 with a sensitivity of 80% and a specificity of 90% to differentiate controls from tonsillectomy patients.ConclusionThe TAHSI performed well in this validation tests and is considered a favorable instrument to evaluate the effectiveness of tonsillectomy in adults with chronic or recurrent tonsillitis. PMID:25367415

Steinbichler, Teresa; Bender, Birte; Blassnigg, Elisabeth; Riechelmann, Herbert

2014-10-31

162

Treatment of c-kit positive adenoid cystic carcinoma of the tongue: A case report.  

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Adenoid cystic carcinoma (ACC) or 'cylindroma' is a malignant tumor that often occurs in the areas of the head and neck, affecting the secretory glands and the major and minor salivary glands. The present study describes a case of a patient who presented with a posterior tongue lesion. The case is of a 71-year-old female with an asymptomatic volume growth of the posterior left tongue perceived 8 months prior, and neoplastic cells positive for c-kit. A computed tomography of the head and neck showed asymmetry of the base of the tongue, which was enlarged in the left portion. A physical examination revealed a nodule on the posterior left tongue of ~3 cm in diameter, while the cervical lymph node chain had a normal size and consistency. Surgical exeresis of the tongue lesion and cervical lymph node dissection were performed. Subsequent to surgical removal of the cancer cells and adjuvant radiotherapy, the patient showed excellent health, although the follow-up remains in progress. ACC, one of the most biologically destructive tumors of the head and neck, is locally aggressive and gives rise to distant metastases. The tongue is the place of origin in 3.4-17.1% of cases. The treatment for ACC consists of primary surgical resection with adjuvant radiotherapy. To prevent the risk for distant metastasis, it is necessary to remove the first echelon nodes and monitor the patient with a long-term follow-up. PMID:24959267

Mesolella, Massimo; Luce, Amalia; Marino, Anna; Caraglia, Michele; Ricciardiello, Filippo; Iengo, Maurizio

2014-07-01

163

Different cDNA microarray patterns of gene expression reflecting changes during metastatic progression in adenoid cystic carcinoma  

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Full Text Available Abstract Background The metastatic ability of tumor cells is determined by level of expression of specific genes that may be identified with the aid of cDNA microarray containing thousands of genes and can be used to establish the expression profile of disease related genes in complex biological system. Materials and Methods Salivary adenoid cystic carcinoma cell line and its high metastases adenoid cystic carcinoma clone were used as model systems to reveal the gene expression alteration related to metastasis mechanism by cDNA microarray analysis. The correlation of metastatic phenotypic changes and expression levels of 4 selected genes (encoding CD98, L6, RPL29, and TSH were further validated by using RT-PCR analysis of human tumor specimens from primary adenoid cystic carcinoma and corresponding metastasis lymph nodes. Results Of the 7,675 clones of known genes and expressed sequence tags (ESTs that were analyzed, 30 showed significantly different (minimum 3 fold expression levels in two cell lines. Out of 30 genes found differentially expressed, 18 were up regulated (with ratio more than 3 and 12 down regulated (with ratio less than 1/3. Conclusion Some of these genes are known to be involved in human tumor antigen, immune surveillance, adhesion, cell signaling pathway and growth control. It is suggested that the microarray in combination with a relevant analysis facilitates rapid and simultaneous identification of multiple genes of interests and in this study it provided a profound clue to screen candidate targets for early diagnosis and intervention.

Yu Fan

2003-12-01

164

Literature review on the role of radiotherapy in the treatment of nasopharyngeal cystic adenoid carcinomas about two cases  

International Nuclear Information System (INIS)

The authors discuss the characteristics and the radiotherapy treatment procedures of cystic adenoid carcinomas, and more precisely the treatment of two of such cases of nasopharyngeal carcinomas. The first one had an incomplete resection surgery followed by curing radiotherapy: he has then been in local-regional control situation for 8 months. The second one had lung metastases, was treated chemotherapy and radiotherapy (decompressive treatment), and died six months after diagnosis. Radiotherapy is considered to be the treatment basis, whereas chemotherapy is a matter of controversy. Short communication

165

Adenoid cystic carcinoma of the breast: report of two cases with immunohistochemical profile of C-kit and MYB overexpression.  

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Adenoid cystic carcinoma (ACC) is a rare tumor with characteristic histologic features. Staining with basal markers for estrogen receptor, progesterone receptor, and HER2 usually shows negative results. Immunohistochemical analysis of C-kit and MYB overexpression of the ACC also has been reported. We report two cases of ACC of the breast with C-kit and MYB overexpression that clinically confirm these previously reported characteristics and suggest that further molecular study of the expression of these two proteins can lead to future therapeutic strategies. PMID:25308019

Chin, Susie; Kim, Zisun

2014-01-01

166

Treatment of locally advanced adenoid cystic carcinoma of the head and neck with neutron radiotherapy  

International Nuclear Information System (INIS)

Purpose: To examine the efficacy of fast neutron radiotherapy for the treatment of locally advanced and/or recurrent adenoid cystic carcinoma of the head and neck and to identify prognostic variables associated with local-regional control and survival. Methods and Materials: One hundred fifty-nine patients with nonmetastatic, previously unirradiated, locally advanced, and/or recurrent adenoid cystic carcinoma (ACC) of the head and neck region were treated with fast neutron radiotherapy during the years 1985-1997. One hundred fifty-one patients had either unresectable disease, or gross residual disease (GRD) after an attempted surgical extirpation. Eight patients had microscopic residual disease and were analyzed separately. Sixty-two percent of patients had tumors arising in minor salivary glands, 29% in major salivary glands, and 9% in other sites such as the lacrimal glands, tracheal-bronchial tree, etc. Fifty-five percent of patients were treated for postsurgical recurrent disease and 13% of patients had lymph node involvement at the time of treatment. The median duration of follow-up was 32 months (range 3-142 months). Actuarial curves for survival, cause-specific survival, local-regional control, and the development of distant metastases are presented for times out to 11 years. Results: The 5-year actuarial local-regional tumor control rate for the 151 patients with GRD was 57%; the 5-year actuarial overall survival rate was 72%; and the 5-year actuarial cause-spwas 72%; and the 5-year actuarial cause-specific survival rate was 77%. Variables associated with decreased local-regional control in the patients with GRD as determined by multivariate analysis included base of skull involvement (p < 0.01) and biopsy only versus an attempted surgical resection prior to treatment (p = 0.03). Patients without these negative factors had an actuarial local-regional control rate of 80% at 5 years. Patients with microscopic residual disease (n = 8) had a 5-year actuarial local-regional control rate of 100%. Base of skull involvement (p < 0.001), lymph node metastases at the time of treatment (p < 0.01), biopsy only prior to neutron radiotherapy (p = 0.03), and recurrent tumors (p = 0.04) were found to be associated with a diminished cause-specific survival as ascertained by multivariate analysis. Patients with base of skull involvement and positive lymph nodes at presentation had an increased rate of the development of distant metastases at 5 years, (p < 0.01 and p <0.001, respectively). No statistical difference in outcome was observed between major and minor salivary gland sites. Conclusions: Fast neutron radiotherapy is an effective treatment for locally advanced ACC of the head and neck region with acceptable toxicity. Further improvements in local-regional control are not likely to impact survival until more effective systemic agents are developed to prevent and/or treat distant metastatic disease

167

Reoperaciones posadenoidectomía por hiperplasia adenoidea obstructiva / Post-adenoidectomy reoperations due to obstructive adenoid hyperplasia  

Scientific Electronic Library Online (English)

Full Text Available SciELO Chile | Language: Spanish Abstract in spanish Introducción: La incidencia de reoperación posadenoidectomía, ya sea una segunda adenoidectomía o una amigdalectomía, no es conocida en nuestro medio. Publicaciones extranjeras muestran 2% de readenoidectomías y 8% de amigdalectomías posteriores. Objetivo: Describir las adenoidectomías efectuadas en [...] nuestro centro, evaluar la prevalencia de reoperaciones y buscar posibles factores asociados a éstas. Material y método: Estudio retrospectivo descriptivo y analítico. Se revisaron fichas de pacientes adenoidectomizados por roncopatía con pausas respiratorias entre enero de 1999 y diciembre 2010. Se registraron datos demográficos, controles y nasofaringolaringoscopías (NFL). Se consignaron las reoperaciones (readenoidectomías y amigdalectomías). Resultados: Se revisaron 106 fichas. Un 55,7% de los pacientes eran hombres. A la NFL, 42% de los pacientes tenían adenoides grado 3y 58% grado 4 de Parikh. Un 5,6% de los pacientes fueron reoperados (1 adenoidectomía y 5 adenoamigdalectomías). Se observó diferencia significativa en edad (p =0,04) y tamaño amigdalino (p =0,004) entre los reoperados y lo no reoperados. No hubo asociación por sexo (p =0,45), asma (p =0,31) ni rinitis (p =0,18). Sin embargo, a la regresión logística multivariada, ninguna variable se asoció significativamente de manera independiente con la necesidad de reoperación. Conclusión: La prevalencia de reoperaciones fue similar a la publicada, no encontrándose asociación con otros factores. Abstract in english Introduction: The incidence of post-adenoidectomy reoperation, be it a second adenoidectomy or a tonsillectomy, is unknown within our environment. Foreign publications show a 2% of re-adenoidectomies and an 8% of ulterior tonsillectomies. Aim: To describe the adenoidectomies performed at our center, [...] to assess the prevalence of reoperations, and to seek possible associated factors to the latter. Material y method: Descriptive and analytical retrospective assessment. A review was performed of records for patients that between January of 1999 and December of 2010 underwent adenoidectomy on account of snoring pathology. Demographics, controls, nasopharyngolaryngoscopies and reoperations (re-adenoidectomies and tonsillectomies) were recorded. Results: The review entailed checking 106 records. 55,7% of patients were men. 42% of patients had Parikh?s Grade III adenoids and 58% showed Grade IV ones. 5,6% of patients underwent reoperation. A significant difference could be observed in age (p=0,04) and tonsillar size (p=0,004) between those that had and had not undergone reoperation. There was no gender association (p=0,45), neither for asthma (p=0,31) or rhinitis (p=0,18). Yet, by multivariate logistic regression, no variable was significantly associated by itself to the need for reoperation. Conclusion: Reoperation prevalence was similar to that published, and no association to other factors was discovered.

Michelle, Arroyo D; Mauricio, Urrutia C; Ariel, Cisternas V.

2014-04-01

168

[Adenoid cystic carcinoma presenting as cavernous sinus syndrome: a clinico-pathological study of two cases].  

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Adenoid cystic carcinoma (ACC), usually arising in the major and minor salivary glands, is well known to otolaryngologists, but is rarely encountered by neurologists or neurosurgeons. We report two ACC patients who presented initially with cavernous sinus syndrome and in whom CT did not demonstrate apparent abnormalities. Case 1 is a 48-year-old man who first developed right cavernous sinus syndrome. The patient came to our hospital four years later. At this time, the only abnormality found on CT was the clouded sphenoid sinus on the left, which was interpreted as sinusitis. Two years later, the repeat CT revealed the enhancing lesions in the area of bilateral cavernous sinuses with bony destruction. The nasolaryngological exploration of the left sphenoid sinus made the diagnosis of ACC. Case 2 is a 43-year-old man who developed unilateral cavernous sinus syndrome over three months. No radiological abnormality was apparent to the neurologist and neurosurgeons, however, the otolaryngologist detected a nasopharyngeal mass diagnosed as ACC. Histological examinations of the biopsy specimen from both cases revealed mixed cribriform, tubular, and solid patterns characteristic of ACC. Electron microscopic study in Case 1 demonstrated microvilli-containing epithelial tumor cells forming true glandular lumens. In these cystic spaces there were cellular debris and crystalloids consisting of hexagonally-arranged tubules with a diameter of 25 nm. Although thick basement membrane was found in the basal portion of the tumor cells facing the connective tissue, there was no so-called pseudocysts lined by replicated basal lamina. It is possible that the specimen examined electron microscopically is limited to a particular epithelial region.(ABSTRACT TRUNCATED AT 250 WORDS) PMID:2553080

Yamamoto, T; Imai, T

1989-05-01

169

High-resolution array comparative genomic hybridization analysis of human bronchial and salivary adenoid cystic carcinoma.  

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Adenoid cystic carcinoma (ACC) is a rare but distinctive tumor. Oligonucleotide array comparative genomic hybridization has been applied for cataloging genomic copy number alterations (CNAs) in 17 frozen salivary or bronchial tumors. Only four whole chromosome CNAs were found, and most cases had 2-4 segmental CNAs. No high level amplification was observed. There were recurrent gains at 7p15.2, 17q21-25, and 22q11-13, and recurrent losses at 1p35, 6q22-25, 8q12-13, 9p21, 12q12-13, and 17p11-13. The minimal region of gain at 7p15.2 contained the HOXA cluster. The minimal common regions of deletions contained the CDKN2A/CDKN2B, TP53, and LIMA1 tumor suppressor genes. The recurrent deletion at 8q12.3-13.1 contained no straightforward tumor suppressor gene, but the MIRN124A2 microRNA gene, whose product regulates MMP2 and CDK6. Among unique CNAs, gains harbored CCND1, KIT/PDGFRA/KDR, MDM2, and JAK2. The CNAs involving CCND1, MDM2, KIT, CDKN2A/2B, and TP53 were validated by FISH and/or multiplex ligation-dependent probe amplification. Although most tumors overexpressed cyclin D1 compared with surrounding glands, the only case to overexpress MDM2 had the corresponding CNA. In conclusion, our report suggests that ACC is characterized by a relatively low level of structural complexity. Array CGH and immunohistochemical data implicate MDM2 as the oncogene targeted at 12q15. The gain at 4q12 warrants further exploration as it contains a cluster of receptor kinase genes (KIT/PDGFRA/KDR), whose products can be responsive to specific therapies. PMID:18332873

Bernheim, Alain; Toujani, Saloua; Saulnier, Patrick; Robert, Thomas; Casiraghi, Odile; Validire, Pierre; Temam, Stéphane; Menard, Philippe; Dessen, Philippe; Fouret, Pierre

2008-05-01

170

Adenoid cystic carcinoma of the trachea and main-stem bronchus. A clinical, histopathologic, and immunohistochemical study.  

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Twelve cases of adenoid cystic carcinoma of the trachea and main-stem bronchus were histologically analyzed, and the results were examined with reference to the growth pattern of the tumor and the prognosis. The tumors were histologically classified into tubular, cribriform, and solid subtypes. Three histologic grades were established: grade I, tumors with tubular and cribriform subtypes but without solid subtype; grade II, tumors with tubular and cribriform subtypes in which the solid subtype comprised less than 20% of the area; grade III, tumors in which the solid subtype comprised more than 20% of the area. Three gross infiltrating types were established: type I, entirely intraluminal; type II, predominantly intraluminal; type III, predominantly extraluminal. In most cases histologic grade correlated with gross tumor type; that is, grades, I, II, and III were grossly types I, II, and III, respectively. The tumors infiltrating along the tracheobronchial wall were of the tubular or cribriform subtype, but not of the solid subtype. In two patients who died of distant metastasis, the histologic studies revealed the solid subtype. Immunohistochemical analysis demonstrated that the tubular subtype was the most differentiated form and the solid subtype, the most undifferentiated form. The histologic subtype of adenoid cystic carcinoma of the tracheobronchial tree was an important factor in the growth pattern of the tumor and the prognosis. PMID:2456426

Nomori, H; Kaseda, S; Kobayashi, K; Ishihara, T; Yanai, N; Torikata, C

1988-08-01

171

A retrospective study of 18 cases of adenoid cystic cancer at a tertiary care centre in Delhi  

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Full Text Available Context: Adenoid cystic carcinoma (ACC is a rare neoplasm that usually arises from the salivary, lacrimal, or other exocrine glands. It is characteristically locally infiltrative in nature and has a tendency toward local recurrence, high propensity for perineural invasion, and prolonged clinical course. Aim: To analyze the presentation and natural history of cases of adenoid cystic tumors of salivary glands in our institution; and to compare with the existing literature. Design and Setting: Retrospective study at the Department of Radiotherapy. Materials and Methods: Data on 18 patients of ACC of the salivary glands treated between 2004 and 2008 were reviewed with respect to clinical presentation, stage, and histology. Results: There were 8 cases of major salivary gland tumors (47%, of which 2 were in the submandibular and 6 were involving the parotid. Ten patients (53% had minor salivary gland involvement. Two patients had metastasis at the time of presentation. All patients underwent surgery. Radiotherapy was delivered to 16 patients and chemotherapy to 6 patients (concurrent, n = 3 and adjuvant, n = 3 and no adjuvant therapy was given to 2 patients. All patients were alive at a median follow-up of 3 years. No patient developed local or distant failure during the study duration. Conclusion: ACC has locally aggressive behavior. Radiotherapy adjuvant to surgery improves local control in locally advanced disease. Longer follow-up is mandatory in view of incidence of late metastasis.

Sharma K

2010-01-01

172

Adenoid cystic carcinoma of the parotid gland: Anastamosis of the facial nerve with the great auricular nerve after radical parotidectomy  

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Full Text Available Adenoid cystic carcinoma of the parotid gland is a rare and slowly growing, but highly malignant tumor. Surgical resection of a malignant parotid tumor should include resection of the facial nerve when the nerve is involved in the tumor. Facial nerve reconstruction is required after nerve resection. A 14 year-old female presented with complaints of painless enlargement of the right parotid gland and facial asymmetry. Physical examination revealed a firm mass in the region of the parotid gland as well as right facial paralysis. Biopsy obtained from the mass showed an adenoid cystic carcinoma of the parotid gland. A radical parotidectomy with a modified radical neck dissection was carried out. Grafting material for the facial reconstruction was harvested from the great auricular nerve. The proximal main trunk and each distal branch of the facial nerve were coapted with the greater auricular nerve. The patient received radiotherapy after surgery and was seen to achieve grade IV facial function one year after surgery. Thus, the great auricular nerve is appropriate grafting material for coaptation of each distal branch of the facial nerve.

Bahadir Osman

2008-01-01

173

Sinonasal tract and nasopharyngeal adenoid cystic carcinoma: a clinicopathologic and immunophenotypic study of 86 cases.  

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Primary sinonasal tract and nasopharyngeal adenoid cystic carcinomas (STACC) are uncommon tumors that are frequently misclassified, resulting in inappropriate clinical management. Eighty-six cases of STACC included 45 females and 41 males, aged 12-91 years (mean 54.4 years). Patients presented most frequently with obstructive symptoms (n = 54), followed by epistaxis (n = 23), auditory symptoms (n = 12), nerve symptoms (n = 11), nasal discharge (n = 11), and/or visual symptoms (n = 10), present for a mean of 18.2 months. The tumors involved the nasal cavity alone (n = 25), nasopharynx alone (n = 13), maxillary sinus alone (n = 4), or a combination of the nasal cavity and paranasal sinuses (n = 44), with a mean size of 3.7 cm. Patients presented equally between low and high stage disease: stage I and II (n = 42) or stage III and IV (n = 44) disease. Histologically, the tumors were invasive (bone: n = 66; neural: n = 47; lymphovascular: n = 33), composed of a variety of growth patterns, including cribriform (n = 33), tubular (n = 16), and solid (n = 9), although frequently a combination of these patterns was seen within a single tumor. Pleomorphism was mild with an intermediate N:C ratio in cells containing hyperchromatic nuclei. Reduplicated basement membrane and glycosaminoglycan material was commonly seen. Necrosis (n = 16) and atypical mitotic figures (n = 11) were infrequently present. Pleomorphic adenoma was present in 9 cases; de-differentiation was seen in two patients. Immunohistochemical studies showed positive reactions for pan-cytokeratin, CK7, CK5/6, CAM5.2, and EMA, with myoepithelial reactivity with SMA, p63, calponin, S100 protein and SMMHC. CD117, CEA, GFAP and p16 were variably present. CK20 and HR HPV were negative. STACC needs to be considered in the differential diagnosis of most sinonasal malignancies, particularly poorly differentiated carcinoma, olfactory neuroblastoma and pleomorphic adenoma. Surgery (n = 82), often accompanied by radiation therapy (n = 36), was generally employed. A majority of patients developed a recurrence (n = 52) 2-144 months after initial presentation. Overall mean follow-up was 19.4 years (range 0.4-37.5 years): 46 patients died with disease (mean 6.4 years); 5 were alive with disease (mean 5.4 years), and 35 patients were either alive or had died of unrelated causes (mean 16.3 years). ACC of the SNT is uncommon. Recurrences are common. The following parameters, when present, suggest an increased incidence of either recurrence or dying with disease: mixed site of involvement, high stage disease (stage IV), skull base involvement, tumor recurrence, a solid histology, perineural invasion, bone invasion, and lymphovascular invasion. PMID:24037641

Thompson, Lester D R; Penner, Carla; Ho, Ngoc J; Foss, Robert D; Miettinen, Markku; Wieneke, Jacqueline A; Moskaluk, Christopher A; Stelow, Edward B

2014-03-01

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[Clinical outcome and clinicopathological prognostic factors in adenoid cystic carcinoma of the head and neck].  

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We retrospectively reviewed the records of the 30 patients with adenoid cystic carcinoma of the head and neck (ACCHN) who had undergone initial treatment in the Department of Otorhinolaryngology, Head and Neck Surgery, Keio University School of Medicine between 1988 and 2007. The primary tumor site was the parotid gland in 10 patients and the submandibular gland in 4 patients, which account for about a half of the subjects. Thirty patients underwent surgical resection with curative intent as the primary treatment, of which 10 patients had post-operative radiotherapy. The 5-and 10-year disease-specific survival (DSS) was 73.9% and 62.4%, respectively, whereas the 5-and 10-year disease-free survival (DFS) was 64.3% and 59.7%, respectively. A univariate analysis revealed that DSS was significantly correlated with perineural invasion (p = 0.010) and lymphatic invasion (p = 0.036), while DFS was significantly correlated with higher T-stage (p = 0.044), a positive surgical margin (p = 0.012) and perineural invasion (p = 0.019). A multivariate analysis demonstrated that perineural invasion (p = 0.034, risk ratio = 9.530) was the independent prognostic factor for DSS, whereas for DFS it was a positive surgical margin (p = 0.038, risk ratio = 8.897). The histological grade classification, defined specifically for ACC, showed no correlation with the survival. Extended resection with wider margin and additional resection in cases with positive margin may improve treatment results, however, surgical resection alone can prevent neither the development of local recurrence mainly attributed to undetectable perineural invasion, nor that of delayed distant metastasis. Therefore, the roles of adjuvant radiotherapy and effective systemic therapies are also significant in ACCHN, although a reliable regimen for the latter has not yet been established. Development of a personalized strategy for the adjuvant therapy, which should be based on the accurate prediction of the long-term prognosis in combination with dependable molecular biomarkers, would be indispensable in the future to improve the clinical outcome of the patients with ACCHN. PMID:24956743

Shigetomi, Seiji; Imanishi, Yorihisa; Shimoda, Masayuki; Tomita, Toshiki; Ozawa, Hiroyuki; Sakamoto, Koji; Fujii, Ryoichi; Habu, Noboru; Otsuka, Kuninori; Yamashita, Taku; Fujii, Masato; Ogawa, Kaoru

2014-05-01

175

SIKVAV, a Laminin ?1-Derived Peptide, Interacts with Integrins and Increases Protease Activity of a Human Salivary Gland Adenoid Cystic Carcinoma Cell Line through the ERK 1/2 Signaling Pathway  

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Adenoid cystic carcinoma is a frequently occurring malignant salivary gland neoplasm. We studied the induction of protease activity by the laminin-derived peptide, SIKVAV, in cells (CAC2) derived from this neoplasm. Laminin ?1 and matrix metalloproteinases (MMPs) 2 and 9 were immunolocalized in adenoid cystic carcinoma cells in vivo and in vitro. CAC2 cells cultured on SIKVAV showed a dose-dependent increase of MMP9 as detected by zymography and colocalization of ?3 and ?6 integrins. Small...

Freitas, Vanessa M.; Vilas-boas, Vanessa F.; Pimenta, Daniel C.; Loureiro, Vania; Juliano, Maria A.; Carvalho, Ma?rcia R.; Pinheiro, Joa?o J. V.; Camargo, Antonio C. M.; Moriscot, Anselmo S.; Hoffman, Matthew P.; Jaeger, Ruy G.

2007-01-01

176

Reliability of adenoid hypertrophy diagnosis by cephalometric radiography / Confiabilidade do diagnóstico da hipertrofia das adenóides por meio da cefalometria  

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Full Text Available SciELO Brazil | Language: English Abstract in portuguese OBJETIVO: Verificar a confiabilidade do diagnóstico da hipertrofia das adenóides por meio da cefalometria. MÉTODOS: Trinta indivíduos do gênero masculino, com idades entre 12 e 15 anos, [...] respiradores bucais ou não, foram selecionados e neles realizados exames de diagnóstico de hipertrofia da adenóide por cefalometria radiológica, a partir da telerradiografia em norma lateral e exames rinoscópicos, a partir da nasofibroscopia (padrão ouro). A cefalometria utilizada foi a computadorizada e para isto se utilizou o programa CefX versão 2000 e a rinoscopia foi realizada com um nasofibroscópio flexível. Foi tomado como ponto de corte 47% e 75% de bloqueio da nasofaringe para a telerradiografia e nasofibroscopia, respectivamente. RESULTADOS: A correlação encontrada entre os dois exames foi considerada moderadamente positiva (0,5) e os testes de validade e confiabilidade registraram uma sensibilidade de 100%, especificidade de 65,5%, valor preditivo positivo de 9,1%, valor preditivo negativo de 100% e exatidão de 66,60%. CONCLUSÃO: A telerradiografia lateral foi considerada um meio prático, confortável para o paciente e relativamente eficiente na detecção da hiperplasia da adenóide e na obtenção do diagnóstico de obstrução nasofaringeana. Abstract in english OBJECTIVE: To verify the reliability of adenoid hypertrophy diagnosis by cephalometric radiography. METHOD: Thirty male subjects, aged between 12 and 15 years, either mouth-breathers, or [...] not, were selected. Diagnostic tests for adenoid hypertrophy were performed by radiological cephalometry based on lateral cephalometric radiographs and nasal endoscopy (gold standard). The CefX Cephalometric software program, version 2000 was used and the rhinoscopy was performed with a flexible endoscope. Blockage of 47% and 75% of the nasopharynx were taken as the cutoff points for cephalometric radiography and endoscopy, respectively. RESULTS: The correlation between the two examinations was considered moderately positive (0.5). Tests of validity and reliability reported a sensitivity of 100%; specificity 65.5%; positive predictive value of 9.1%; negative predictive value 100%, and exactness of 66.60%. CONCLUSION: Lateral cephalometric radiography was considered practical and comfortable for the patient; relatively efficient for detecting adenoid hypertrophy and obtaining the diagnosis of nasopharyngeal airway obstruction.

Alexandre Jose, RETCHESKI; Nelson Padilha da, SILVA; Fernanda, LEITE; Paulo Roberto Aranha, NOUER.

2014-09-01

177

Radiographic adenoid evaluation: proposal of an objective parameter / Avaliação radiográfica da tonsila faríngea: proposição de um método de medição objetivo  

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Full Text Available SciELO Brazil | Language: English Abstract in portuguese Objetivo O objetivo deste estudo foi avaliar parâmetros radiográficos atuais destinados à verificação da adenoide e obstrução nasofaríngea e apresentar um método de avaliação alternativo. Materiais e Métodos Crianças (4 a 14 anos) que apresentavam queixas de obstrução nasal e/ou respiração oral f [...] oram submetidas ao exame radiográfico de cavum faríngeo. Cento e vinte registros foram avaliados por parâmetros radiográficos quantitativos, e estes dados foram correlacionados ao exame de videonasofaringoscopia, aqui considerado como padrão ouro, em relação à porcentagem de obstrução coanal. Posteriormente, uma análise de regressão foi realizada com os mesmos parâmetros quantitativos, de modo que um modelo original fosse criado com o objetivo de predição do percentual de obstrução coanal. Resultados Os parâmetros quantitativos atuais demonstraram correlações moderadas, quando não fracas, ao percentual de obstrução. O modelo de regressão desenvolvido (110.119*A/N) demonstrou capacidade satisfatória de “prever” o real percentual de obstrução adenóidea. Conclusão Uma vez que os parâmetros radiográficos atuais apresentam limitações, o modelo original aqui apresentado deve ser considerado como um método de avaliação adenóidea alternativo, a ser utilizado quando a videonasofaringoscopia estiver indisponível. Abstract in english Objective The objective of the present study was to evaluate current radiographic parameters designed to investigate adenoid hypertrophy and nasopharyngeal obstruction, and to present an alternative radiographic assessment method. Materials and Methods In order to do so, children (4 to14 years ol [...] d) who presented with nasal obstruction or oral breathing complaints were submitted to cavum radiographic examination. One hundred and twenty records were evaluated according to quantitative radiographic parameters, and data were correlated with a gold-standard videonasopharyngoscopic study, in relation to the percentage of choanal obstruction. Subsequently, a regression analysis was performed in order to create an original model so the percentage of the choanal obstruction could be predicted. Results The quantitative parameters demonstrated moderate, if not weak correlation with the real percentage of choanal obstruction. The regression model (110.119*A/N) demonstrated a satisfactory ability to “predict” the actual percentage of choanal obstruction. Conclusion Since current adenoid quantitative radiographic parameters present limitations, the model presented by the present study might be considered as an alternative assessment method in cases where videonasopharyngoscopic evaluation is unavailable.

Murilo Fernando Neuppmann, Feres; Juliana Sato, Hermann; Ana Carolina, Sallum; Shirley Shizue Nagata, Pignatari.

2014-04-01

178

Long-term survival of a patient with extensive intracranial infiltration of adenoid cystic carcinoma of the lacrimal gland  

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Adenoid cystic carcinoma (ACC) of the lacrimal gland is a rare neoplasm associated with poor prognosis. Because of its inherent tendency toward local infiltration and perineural spread, involving a high risk of local recurrences and intracranial extension as well as the risk of regional lymph node and distant metastases development, aggressive approach with orbital exenteration, irradiation and chemotherapy has been used. However, the natural course of ACC of the lacrimal gland is not well known. We present a case of long-term survival of a 48-year-old male patient with ACC located in the lacrimal gland, who underwent non-radical resection of malignant tumor and received palliative chemotherapy with doxorubicin and cisplatin. This patient lived for almost 14 years after diagnosis. Thirteen out of teahouse years the patient lived without serious complaints, and in good performance status. (authors)

179

An unusual presentation of adenoid cystic carcinoma of the minor salivary glands with cranial nerve palsy: a case study  

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Full Text Available Abstract Background Adenoid Cystic Carcinoma (ACC is a rare tumor entity and comprises about 1% of all malignant tumor of the oral and maxillofacial region. It is slow growing but a highly invasive cancer with a high recurrence rate. Intracranial ACC is even more infrequent and could be primary or secondary occurring either by direct invasion, hematogenous spread, or perineural spread. We report the first case of the 5th and 6th nerve palsy due to cavernous sinus invasion by adenoid cystic carcinoma. Case presentation A 49-year-old African American female presented to the emergency room complaining of severe right-sided headache, photophobia, dizziness and nausea, with diplopia. The patient had a 14 year history migraine headaches, hypertension, and mild intermittent asthma. Physical examination revealed right lateral rectus muscle palsy with esotropia. There was numbness in all three divisions of the right trigeminal nerve. Motor and sensory examination of extremities was normal. An MRI of the brain/brain stem was obtained which showed a large mass in the clivus extending to involve the nasopharynx, pterygoid plate, sphenoid and right cavernous sinuses. Biopsy showed an ACC tumor with a cribriform pattern of the minor salivary glands. The patient underwent total gross surgical resection and radiation therapy. Conclusion This is a case of ACC of the minor salivary glands with intracranial invasion. The patient had long history of headaches which changed in character during the past year, and symptoms of acute 5th and 6th cranial nerve involvement. Our unique case demonstrates direct invasion of cavernous sinus and could explain the 5th and 6th cranial nerve involvement as histopathology revealed no perineural invasion.

Morris Pierre A

2007-08-01

180

Hubungan Imunoekspresi E-cadherin dan C-erbB2 dengan Derajat Keganasan Histopatologik Karsinoma Kistik Adenoid Kelenjar Liur  

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Full Text Available Adenoid cystic carcinoma (ACC is the most common salivary gland malignancies, with high rate of local recurrence and unpredictable prognosis. Based on previous research, prognosis of ACC in salivary gland which is correlated with survival rates, is related with histopathological malignancy degree based on its growth pattern type. This study was conducted in Pathology Anatomy Department of Medical Faculty, Padjadjaran University Bandung in 2009. The aim of this study was to analyze the alteration of immunoexpression of E-cadherin (adhesion molecule of epithelial cells and C-erbB2 proto-oncogen (the family of C-erbB/epidermal growth factor receptor in salivary gland. Adenoid cystic carcinoma correlated with cross-sectional non-random study on 51 paraffin blocks, from patients with salivary gland ACC retrospectively. The repeated histopatologic examination was to diagnose ACC and to get data of the histopathological malignancy degree (according to Szantos and Batsakis modification, and it was continued with immunohistochemistry examination of E-cadherin and C-erbB2. The alteration of negative immunoexpression of E-cadherin (82% had correlation significantly (p<0.001 with the histological malignancy degrees 1, 2, and 3 (4%, 33% and 46%. The C-erbB2 immunoexpression change had no correlation with the increasing histopatologic malignancy degree (p=0.11. The alteration of C-erbB2 immunoexpression, increased from first (5% to second degree (11% but decreased on the third degree (8%. In conclusions, the immunoexpression of E-cadherin can be used as tumor marker to predict malignancy prognosis of salivary gland ACC. The expression changes of C-erbB2 in ACC indicate its biological behavior and the main role of C-erbB2 on salivary gland ACC is in the initiation and promotion phase of carcinogenesis.

Marry Siti Mariam

2012-06-01

181

Endoscopic-assisted microscopic decompression of adenoid cystic carcinoma of paranasal sinus extending to the sella: A case report and review of literature  

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Full Text Available Technological development in neuroendoscopy has lead to an expansion of its applications. The dimensions of a microsurgical approach to the brain can greatly be enlarged with the use of endoscope, making it possible to look behind structures and around corners. We performed an endoscopic assisted microsurgical decompression of an adenoid cystic carcinoma of paranasal sinus with intracranial sellar extension with good results.

Tripathy Pradipta

2009-01-01

182

A case report of coexistence of a sialolith and an adenoid cystic carcinoma in the submandibular gland  

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Full Text Available SciELO Spain | Language: English Abstract in english Ôhe occurrence of sialoliths in the submandibular gland is 80% due to the specific anatomy of both the gland and its duct. The diagnosis is rather easy because of the obvious clinical signs of the entity. Imaging studies are always necessary in order to treat the patient as effectively as possible. [...] The stones do not tend to occur within the gland as frequently as in the respective duct. The coexistence of sialoliths and malignant tumors is extremely rare. A 70-year-old woman with intraparenchymal stone was operated in our ENT department. In addition to the sialolith the pathological examination revealed the existence of an adenoid cystic carcinoma (ACC), that extended to the neighboring skeletal muscle. This is the reason why we believe it would be useful to report this case of a large stone (14 mm in diameter) located in the submandibular gland coexisting with ACC. This case report is a very good example illustrating that all available means should be used prior to reaching a conclusion and making a health professional decision.

Dimitrios, Batzakakis; Kostas, Apostolopoulos; Ioannis, Bardanis.

2006-06-01

183

Long-term remission of adenoid cystic tongue carcinoma with low dose naltrexone and vitamin D3--a case report.  

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Naltrexone (ReVia®) is a long-acting oral pure opiate antagonist which is approved for the treatment of alcohol addiction as a 50mg per day tablet. The mechanism of action is complete opiate blockade, which removes the pleasure sensation derived from drinking alcohol (created by endorphins). Low Dose Naltrexone ("LDN") in the range of 3-4.5 mg per day has been shown to have the opposite effect - brief opiate receptor blockade with resulting upregulation of endogenous opiate production. Through the work of Bihari and Zagon, it has been determined that the level of the endogenous opiate methionine-enkephalin is increased by LDN. Met-enkephalin is involved in regulating cell proliferation and can inhibit cancer cell growth in multiple cell lines. Increased met-enkepahlin levels created by LDN thus have the potential to inhibit cancer growth in humans. Phase II human trials of met-enkephalin, case reports published by Berkson and Rubin, and the clinical experience of Bihari confirmed the potential role of LDN in treating pancreatic and other cancers. However, large scale trials are lacking and are unlikely to be funded given the current non-proprietary status of naltrexone. A case report is presented of successful treatment of adenoid cystic carcinoma as further evidence of LDN's potential as a unique non-toxic cancer therapy. PMID:25284545

Khan, Akbar

2014-09-01

184

Role of chemotherapy and molecularly targeted agents in the treatment of adenoid cystic carcinoma of the lacrimal gland.  

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Adenoid cystic carcinoma (ACC) is the most common malignant epithelial cancer of the lacrimal gland. Despite a slow rate of growth, ACCs are ultimately associated with poor clinical outcome. Given the rarity of this disease, most recommendations regarding therapy are guided by expert opinion and retrospective data rather than level 1 evidence. Surgery and postoperative radiation therapy are commonly used as initial local treatment. In patients at high risk of recurrence, concomitant platinum-based chemotherapy may be added to postoperative radiotherapy in an attempt to enhance radio-sensitivity. While encouraging responses have been reported with intra-arterial neoadjuvant chemotherapy, this strategy is associated with substantial toxicity and should be considered investigational. For patients with metastatic disease not amenable to surgery or radiotherapy, chemotherapy may have a role based on its modest efficacy in non-lacrimal ACC. Similarly, molecular targeted agents may have a role, although the agents tested to date in non-lacrimal ACC have been disappointing. A better understanding of the biology of ACC will be crucial to the future success of developing targeted agents for this disease. PMID:21183517

Le Tourneau, Christophe; Razak, Albiruni R A; Levy, Christine; Calugaru, Valentin; Galatoire, Olivier; Dendale, Rémi; Desjardins, Laurence; Gan, Hui K

2011-11-01

185

Increased numbers of P63-positive/CD117-positive cells in advanced adenoid cystic carcinoma give a poorer prognosis  

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Full Text Available Abstract Objectives This study consisted of two parts. One part was to analyze the survival rates of adenoid cystic carcinoma (ACC in Chinese and explain the difference between our data and the literature. The other was to analyze the relationship between the expression of CD117 and the histological grade and the prognosis. Methods A retrospective study of 80 ACC patients was performed. Clinical data were collected, and p63, CD117 were detected by immunohistochemical staining. Results Eighty patients received follow-ups 3 to 216?months after initial diagnosis. ACC occurred in the lacrimal gland (26.3%, n?=?21, nasal cavity and parasinus (33.8%, n?=?27 and other sites (40.0%, n?=?33. The 5-year and 10-year survival rates were 66.41% and 10.16%, respectively. Over expression of CD117 was detected in p63-negative cells in 94.3% of cases and in p63-positive cells in 45.8%. The expression of CD117 in p63-positive cells was significantly associated with the histological grade (P Conclusions ACC had a good 5-year survival but poor 10-year survival in Chinese, which differed from the occidental data. More p63+/CD117+ cells were associated with a higher histological grade and poorer outcome. Virtual slides The virtual slide(s for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1701457278762097

Zhou Quan

2012-09-01

186

125I brachytherapy alone for recurrent or locally advanced adenoid cystic carcinoma of the oral and maxillofacial region  

International Nuclear Information System (INIS)

Background and purpose: This retrospective study was to evaluate the local control and survival of 125I brachytherapy for recurrent and/or locally advanced adenoid cystic carcinoma (ACC) of the oral and maxillofacial region. Patients and methods: A total of 38 patients with recurrent and/or locally advanced ACC of the oral and maxillofacial region received 125I brachytherapy alone from 2001-2010. Twenty-nine were recurrent cases following previous surgery and radiation therapy. The other 9 cases involved primary tumors. Overall, 12 tumors were located in the major salivary glands, 12 in the minor salivary glands, and 14 in the paranasal region, the nasal cavity or the skull base. The prescribed dose was 100-160 Gy. Results: Patients were followed for 12-122 months (median 51 months). The 2-, 5-, and 10-year local tumor control rates were 86.3, 59, and 31.5 %, respectively. The 2-, 5-, and 10-year overall survival rates were 92.1, 65 and 34.1 %, respectively. Tumors > 6 cm had significantly lower local control and survival rates. No severe complications were observed during follow-up. Conclusion: 125I brachytherapy is a feasible and effective modality for the treatment of locally advanced unresectable or recurrent ACC. (orig.)

187

Analysis of failure in patients with adenoid cystic carcinoma of the head and neck an international collaborative study  

DEFF Research Database (Denmark)

BACKGROUND Adenoid cystic carcinoma (ACC) is a locally aggressive tumor with a high prevalence of distant metastases. The current study aimed to identify independent predictors of outcome and to characterize the patterns of failure. METHODS: An international retrospective review of 489 ACC patients treated between 1985 and 2011 in 9 cancer centers worldwide. RESULTS: Five-year overall-survival (OS), disease-specific survival(DSS) and disease-free survival (DFS) were 76%, 80% and 68%, respectively. Independent predictors of OS and DSS were: age, site, N classification and presence of distant metastases(DM). N stage, age and bone invasion were associated with DFS on multivariate analysis. Age, tumor site, orbital invasion and N stage were independent predictors of DM. CONCLUSION: The clinical course of ACC is slow but persistent. Paranasal sinus origin is associated with the lowest distant metastasis rate but with the poorest outcome. These prognostic estimates should be considered when tailoring treatment for patients with ACC. Head Neck, 2013.

Amit, Moran; Binenbaum, Yoav

2013-01-01

188

Clinicopathological significance of L-type amino acid transporter 1 (LAT1) expression in patients with adenoid cystic carcinoma.  

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The expression of L-type amino acid transporter 1 (LAT1) is correlated with tumor cell growth and survival. However, the clinicopathological significance of LAT1 expression in adenoid cystic carcinoma (ACC) remains to be elucidated. The aim of this study is to investigate the clinicopathological significance of LAT1 expression in ACC. A total of 30 patients with ACC were retrospectively reviewed. Tumor sections were stained by immunohistochemistry for LAT1, p53, and CD98, and cell proliferation and microvessel density (MVD) were determined by Ki-67 and CD34, respectively. High LAT1 and CD98 expression were observed in 27 % (8/30) and 23 % (7/30) of samples, respectively (p > 0.999). The high expression of LAT1 was significantly correlated with cell proliferation (Ki-67) and the cell cycle regulator p53. By univariate analysis, solid histological pattern, maxillary tumor site, LAT1, CD98, Ki-67 and p53 were significantly associated with poor prognosis. Multivariate analysis demonstrated that the high expression of LAT1 was an independent prognostic factor for predicting poor prognosis after surgical resection. LAT1 is a promising clinical marker to predict the outcome after surgery in patients with ACC. PMID:23516127

Kaira, Kyoichi; Toyoda, Minoru; Shino, Masato; Sakakura, Koichi; Takahashi, Katsumasa; Tominaga, Hideyuki; Oriuchi, Noboru; Kanai, Yoshikatsu; Oyama, Tetsunari; Chikamatsu, Kazuaki

2013-10-01

189

Induction of autophagy-dependent cell death by the survivin suppressant YM155 in salivary adenoid cystic carcinoma.  

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Adenoid cystic carcinoma (ACC) is one of the most common malignancies of the major and minor salivary glands. However, the molecular mechanism underlying the aggressive growth of human salivary ACC remains unclear. In the present study, we showed that survivin, which belongs to the family of inhibitors of apoptosis, is closely related to the high expression of CDK4 and cyclin D1 in human ACC specimens. By employing the small-molecule drug YM155, we found that the inhibition of survivin in ACC cells caused significant cell death and induced autophagy. Chloroquine, an autophagy inhibitor, prevented cell death induced by YM155, suggesting YM155-induced autophagy contributed to the cell death effects in ACC cells. More importantly, evidence obtained from a xenograft model using ACC-2 cells proved the occurrence of YM155-induced autophagy and cell death in vivo was correlated with the suppression of Erk1/2 and S6 activation as well as increased TFEB nuclear translocation. Taken together, our results indicate YM155 is a novel inducer of autophagy-dependent cell death and possesses therapeutic potential in ACC. PMID:24370995

Wang, Yu-Fan; Zhang, Wei; He, Ke-Fei; Liu, Bing; Zhang, Lu; Zhang, Wen-Feng; Kulkarni, Ashok B; Zhao, Yi-Fang; Sun, Zhi-Jun

2014-04-01

190

EXPRESSION OF MATRIX METALLOPROTEINASE MMP-2 AND ITS TISSUE INHIBITOR TIMP-2 IN INTRAORAL PLEOMORPHIC ADENOMA AND ADENOID CYSTIC CARCINOMA  

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Full Text Available Matrix metalloproteinases (MMPs are proteolytic enzymes that are capable of degrading different substrates within extracellular matrix (ECM, and are believed to be crucial for tumor invasion and metastasis. Tissue inhibitors of MMP (TIMPs can inhibit the action of MMPs The aim of this study was to analyze protein expression of MMP-2 and TIMP-2 in intraoral pleomorphic adenoma (PLA and adenoid cystic carcinoma (ACC. A total of 35 formalin-fixed paraffin-embedded specimens comprising 19 PLA and 16 ACC were utilized in this study. A standard immunohistochemical technique was used to determine the expression levels of MMP-2 and TIMP-2 proteins. Sections were assessed semi quantitatively .Staining was scored as 0 ( 50% positive tumor cells. For statistical analysis, tumors were divided into two groups, low expressors ( 0-1+ and high expressors (2-3+. PLA showed higher TIMP-2 expression than ACC (p<0.05. No significant difference was observed between PLA and ACC regarding MMP-2 expression. MMP-2 and TIMP-2 expressed mainly in the cytoplasm of epithelial/ myoepithelial components of PLA and neoplastic epithelial cells of ACC. Myoepithelial cells may be the primary source of gelatinases in PLA and the down regulation of TIMP-2 expression in ACC might be responsible for metastasis and recurrence. The ratio value of MMP-2/TIMP-2 is valuable parameter to demonstrate the ECM degradation/ deposition imbalance.

Natheer Hashim AL-Rawi

2011-04-01

191

Multinucleated stromal giant cells in adenoid cystic carcinoma of the breast: A case report and literature review  

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Full Text Available Background. We presented an unusual case of adenoid cystic carcinoma (ACC of the breast with multinucleated stromal giant cells (MSGCs. To the best of our knowledge, the occurrence of ACC with MSGCs has not been reported previously. MSGCs should be distinguished from other multinucleated giant cells in breast tumors. The histogenesis of MSGCs still remains obscure. In hope to elucidate the histogenesis of MSGCs, we used a broad range of antibodies. Case report. A 40-year-old woman presented with a palpable lump in the subareolar location of her right breast. Excision of the tumor was performed. At gross pathologic examination the tumor was 20 × 15 × 15 mm in size, redbrown and well circumscribed. The surgical margins were positive for carcinoma and skin-sparing mastectomy with axillary dissection was complited. Eighteen lymph nodes examined were uninvolved. Patohistological examination showed ACC with numerous MSGCs scattered within tumor stroma. Immunohistochemical studies indicated that MSGCs are probably derived from stromal fibroblasts. These cells showed strong reactivity only for vimentin. Staining for histiocytic marker (CD68, as well as for epithelial marker (cytokeratin, myoepithelial markers (S-100, ?- smooth muscle actin, vascular marker (CD34, hormonal receptors (ER, PR and HER2 in MSGCs were negative. Conclusion. The presence of MSGCs should not alter the prognosis of an otherwise typical breast ACC.

Jovi?i?-Milentijevi? Maja

2011-01-01

192

High Expression of SOX2 Is Associated with Poor Prognosis in Patients with Salivary Gland Adenoid Cystic Carcinoma  

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Full Text Available Sex determining region Y-BOX2 (SOX2, one of the key members of the SOX family, is a transcription factor that is involved in the maintenance of embryonic stem cell pluripotency and in multiple developmental processes. Recent studies have shown that SOX2 is aberrantly expressed in several types of tumors. The present study aimed to investigate the clinicopathological and prognostic significance of SOX2 in adenoid cystic carcinoma (ACC of salivary gland. In this study, the expression of SOX2 in ACC tissues and matched adjacent non-cancerous tissues was measured by immunohistochemistry, western blot, and quantitative polymerase chain reaction. High SOX2 expression occurred in approximately 62.6% of primary ACC. In addition, high expression of SOX2 was significantly associated with T classification (p = 0.003 and distant metastasis (p = 0.002. The 5-year overall survival (OS and disease-free survival (DFS in patients with high SOX2 expression is poorer than those with low SOX2 expression. When adjusted by multivariate analysis, high SOX2 expression, together with distant metastasis, was an independent prognostic factor. The findings of the present study provide evidence that SOX2 represents a potential novel prognostic biomarker for ACC patients.

Wei Dai

2014-05-01

193

Effects of 5-aza-2?deoxycytidine on RECK gene expression and tumor invasion in salivary adenoid cystic carcinoma  

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Full Text Available SciELO Brazil | Language: English Abstract in english Reversion-inducing cysteine-rich protein with kazal motifs (RECK), a novel tumor suppressor gene that negatively regulates matrix metalloproteinases (MMPs), is expressed in various normal human tissues but downregulated in several types of human tumors. The molecular mechanism for this downregulatio [...] n and its biological significance in salivary adenoid cystic carcinoma (SACC) are unclear. In the present study, we investigated the effects of a DNA methyltransferase (DNMT) inhibitor, 5-aza-2?deoxycytidine (5-aza-dC), on the methylation status of the RECK gene and tumor invasion in SACC cell lines. Methylation-specific PCR (MSP), Western blot analysis, and quantitative real-time PCR were used to investigate the methylation status of the RECK gene and expression of RECK mRNA and protein in SACC cell lines. The invasive ability of SACC cells was examined by the Transwell migration assay. Promoter methylation was only found in the ACC-M cell line. Treatment of ACC-M cells with 5-aza-dC partially reversed the hypermethylation status of the RECK gene and significantly enhanced the expression of mRNA and protein, and 5-aza-dC significantly suppressed ACC-M cell invasive ability. Our findings showed that 5-aza-dC inhibited cancer cell invasion through the reversal of RECK gene hypermethylation, which might be a promising chemotherapy approach in SACC treatment.

X.Q., Zhou; S.Y., Huang; D.S., Zhang; S.Z., Zhang; W.G., Li; Z.W., Chen; H.W., Wu.

194

International collaborative validation of intraneural invasion as a prognostic marker in adenoid cystic carcinoma of the head and neck  

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BACKGROUND: The purpose of this study was to characterize the incidence, pattern of spread, and prognostic correlation of nerve invasion in patients with adenoid cystic carcinoma (ACC). METHODS: Using 3 different pathological categories of perineural invasion, intraneural invasion, and perineural inflammation, we investigated the prognostic value of nerve invasion in a total of 495 ACCs from 9 international patient cohorts with median follow-up 90 months (range, 12-288 months). RESULTS: Of 239 patients (48%) with nerve invasion, 174 (73%) had perineural invasion, 65 (27%) intraneural invasion, and 37 (15%) perineural inflammation. Multivariate Cox regression analysis identified tumor site (p = .008; hazard ratio [HR] = 1.8; 95% confidence interval [CI] = 0.07-3.7) and intraneural invasion (p < .001; HR = 5.9; 95% CI = 0.8-12.3) as independent prognostic markers for both overall survival (OS) and disease-specific survival (DSS), but not of distant metastases. CONCLUSION: Although perineural invasion has no impact on survival, intraneural invasion is an independent predictor of poor prognosis. Recognition of intraneural invasion may help optimize treatment of patients with head and neck ACC. © 2014 Wiley Periodicals, Inc. Head Neck, 2014.

Amit, Moran; Binenbaum, Yoav

2015-01-01

195

Prevention of surgery in children with adenoidal hypertrophy treated with intranasal flunisolide: a 12-month follow-up.  

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Adenoidal hypertrophy (AH) represents one of the most frequent indications for surgery in children. Recently, treatment with intranasal corticosteroids has been suggested to decrease the size of AH. The aim of the study is to evaluate the long-term effect of intranasal flunisolide on AH during a 12-month follow-up. One hundred seventy-eight children with a grade III or IV AH at baseline endoscopic examination were enrolled in this randomised and controlled study. Children were treated with intranasal flunisolide or isotonic saline solution for 8 weeks. Subsequent assessment, including history and fiberoptic endoscopy, was made at 8 weeks, and 6 and 12 months after treatment suspension. Flunisolide treatment was initially associated with significant (p<0.01) reduction of the degree of AH. However, during follow-up all but one of the non-allergic children relapsed, whereas most allergic children maintained AH size reduction (p<0.05). No clinically important adverse events were reported. In conclusion, this preliminary study demonstrates that an 8-week treatment with intranasal flunisolide is significantly associated with reduction of AH, however, the adenoidectomy avoidance was warranted only for allergic children. PMID:19589290

Varricchio, A; Tortoriello, G; Capasso, M; De Lucia, A; Marchisio, P; Varricchio, A M; Mansi, N; Giordano, L; Liberatore, G; Di Gioacchino, M; Ciprandi, G

2009-01-01

196

Effects of small interfering RNA targeting thymidylate synthase on survival of ACC3 cells from salivary adenoid cystic carcinoma  

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Full Text Available Abstract Background Thymidylate synthase (TS is an important target for chemotherapeutic treatment of cancer and high expression of TS has been associated with poor prognosis or refractory disease in several cancers including colorectal and head and neck cancer. Although TS is known to regulate cell cycles and transcription factors, its potency as a therapeutic target has not been fully explored in adenoid cystic carcinoma (ACC. Methods An ACC cell line (ACC3 was transfected with siRNA targeting the TS gene and inhibition of cell growth and induction of apoptosis-associated molecules were evaluated in vitro. In addition, the in vivo effect of TS siRNA on tumor progression was assessed using a xenograft model. Results Our results demonstrated that ACC3 cells showed significantly higher TS expression than non-cancer cell lines and the induction of TS siRNA led to inhibition of cell proliferation. The effect was associated with an increase in p53, p21, and active caspase-3 and S-phase accumulation. We also found up-regulation of spermidine/spermine N1-acetyltransferase (SSAT, a polyamine metabolic enzyme. Furthermore, treatment with TS siRNA delivered by atelocollagen showed a significant cytostatic effect through the induction of apoptosis in a xenograft model. Conclusion TS may be an important therapeutic target and siRNA targeting TS may be of potential therapeutic value in ACC.

Kakehata Seiji

2008-11-01

197

c-Kit Expression is Rate-Limiting for Stem Cell Factor-Mediated Disease Progression in Adenoid Cystic Carcinoma of the Salivary Glands12  

OpenAIRE

Adenoid cystic carcinoma (ACC) is an aggressive malignant neoplasm of the salivary glands in which c-Kit is overexpressed and activated, although the mechanism for this is as yet unclear. We analyzed 27 sporadic ACC tumor specimens to examine the biologic and clinical significance of c-Kit activation. Mutational analysis revealed expression of wild-type c-Kit in all, eliminating gene mutation as a cause of activation. Because stem cell factor (SCF) is c-Kit's sole ligand, we analyzed its expr...

Phuchareon, Janyaporn; Zante, Annemieke; Overdevest, Jonathan B.; Mccormick, Frank; Eisele, David W.; Tetsu, Osamu

2014-01-01

198

Lacrimal gland adenoid cystic carcinoma with high-grade transformation to myoepithelial carcinoma: report of a case and review of literature.  

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Adenoid cystic carcinoma (AdCC) is the most frequent malignant neoplasm of the lacrimal glands. Like its salivary gland counterpart, lacrimal AdCC can rarely undergo high-grade transformation ("dedifferentiation"). We herein report the clinical, radiographic and microscopic findings of a lacrimal gland AdCC with high grade transformation, occurring in a 39-year-old female patient. In contrast to salivary gland AdCC with high-grade transformation, which usually shows a high grade component with "ductal" differentiation, in the case presented, the "dedifferentiated" component showed morphologic and immunohistochemical features of myoepithelial differentiation. PMID:22829347

Argyris, Prokopios P; Pambuccian, Stefan E; Cayci, Zuzan; Singh, Charanjeet; Tosios, Konstantinos I; Koutlas, Ioannis G

2013-03-01

199

Aggressive Adenoid Cystic Carcinoma With Asymptomatic Spinal Cord Compression Revealed By A “Curtain Sign”  

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Full Text Available The author presents a case with an unusually aggressive evolution of an adenoid cystic carcinoma of the head and neck. The patient presented with sciatica one year after initial diagnosis. She was otherwise asymptomatic. Complete work-up for bone involvement, included bone scan and MRI. The patient had asymptomatic thoracic (T5 vertebral metastasis revealed by a typical curtain sign on MRI. She benefited from radiotherapy and did not develop respiratory distress, paraplegia or pain but died of other metastases.

Martin Housset

2008-08-01

200

Therapeutic strategies for adenoid cystic carcinoma of the nasal and paranasal sinus from the long-term treatment results  

International Nuclear Information System (INIS)

This article presents long-term treatment results by analyzing 24 cases with adenoid cystic carcinoma (ACC) of the nasal and paranasal sinus treated from 1975 to 1995 at Akita University Hospital and Chiba University Hospital. The basic strategies for treatment for ACC of the nasal and paranasal sinuses are en bloc tumor resection, followed by primary reconstruction of the maxilla. Preoperative and postoperative radiation were combined. Cumulative 5-year and 10-year survival rates were 70.6% and 47.1% for maxillary sinus tumors, respectively. Cumulative 5-year and 10-year survival rates for nasal tumors were 100% and 75.0%, and those for sphenoid sinus tumors were 50.0% and 0%, respectively. The patient with ethomoid sinus who needed skull base surgery is alive at 8.1 years after therapy. Treatment results closely correlated with tumor extension. Cumulative 5-year survival rates for T2, T3 and, T4 patients with maxillary sinus tumors were 85.7%, 71.4%, and 33.3%, respectively. And cumulative 10-year survival rates for T2, T3, and T4 were 71.4%, 42.9%, and 0%, respectively. The histopathological effects of preoperative radiation were Shimosato II a in 6 out of 10 patients, II b in 2, and III in 2, respectively. Only fast neutron therapy reached Shimosato III. Two of the patients with Shimosato II a died of distant metastasis. The above data suggests that, although radiation therapy alone cannot cure tumors, preoperative full-dose radiation may prevent the development ose radiation may prevent the development of distant metastasis if it can achieve histopathological effects of a higher classification than Shimosato II b. Because chemotherapy and radiation is not very effective on ACC, the role of skull base surgeries for nasal-paranasal sinus malignancies that invade the skull base is valuable, particularly in cases having a relatively small mass in the ethmoid sinus. (author)

201

A 20-Year Retrospective Study of Salivary Gland Adenoid Cystic Carcinoma in a Sample of Iranian Patients  

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Full Text Available Objective: The aim of the present study was to investigate the demographic and pathological aspects of adenoid cystic carcinomas (ACC in an Iranian sample based on a 20-year archive review.Materials and Methods: In this descriptive study, tumors of the head and neck registered between 1980 and 2000 were evaluated and cases of ACC were selected. Patients’ medical records and pathology reports were reviewed. Variables such as age, sex, duration of disease,symptoms, site of tumor involvement and tumor diameter as well as pathologic features were recorded. Analysis was performed using chi-square and t-tests; P<0.05 was considered as the level of significance.Results: ACC was the most common malignant tumor followed by mucoepidermoid carcinoma and adenocarcinoma NOS. A total of 120 ACCs were found, of which 50.8% occurred in females and 49.2% in males. Patients’ ages ranged from 5 to 90 with a mean of 49.2 (SD=15.9 years. In 60.9% of cases, minor salivary glands were involved and the palate was the most common site. The greatest tumor diameter was between 2-15cm with a mean of 4.6 cm (SD=2.9. The most prevalent histologic appearance was cribriform, followed by tubular pattern. No significant relation was observed between lymph node metastasisand patients’ age, sex, disease duration, greatest tumor diameter and site of involvement.Conclusion: Our findings were relatively similar to other reports from different parts of the world. Further analytic and case-control studies are recommended to gain a better understanding of different aspects of ACC.

M. Khalili

2009-03-01

202

The Role of Radiation Therapy in the Treatment of Adenoid Cystic Carcinoma of the Head and Neck  

International Nuclear Information System (INIS)

Forty eight patients with adenoid cystic carcinoma(ACC) in the head and beck treated between 1979 and 1990 were reviewed according to treatment modalities and clinical courses. The common site of origin was minor salivary gland (69%), mostly had palate and maxillary sinus. 11 patients received radiation therapy(RT) alone and 37 patients received combined surgery and radiation therapy. The follow-up period of the survivors ranged from 4 to 118 months (median 49.5 months). The 5 year local control rate was 69.3%, 67.3% and 83.9% in RT alone, conservative operation(OP)+RT and radical OP+RT group, respectively(p>0.05). The control of local disease was best achieved with radical OP+RT. In postoperative RT, high dose (?60 Gy) and generous field size (>64cm2) yielded a better local control rate. Actuarial overall survival rate was 79.0%, at 5 years and 19.2% at 10 years. Distant metastases (DM) developed in 40% of patients, mostly in the lung. Disease-free(NED) survival rate was 45.8%, at 5 years and significant differences did not exist according to primary sites and treatment options. Survival rate after the onset of DM was 19.5% at 5 years. Occurrence of DM tends to lower survival significantly. In an effort to find the role of RT in the treatment of ACC, our data suggest that a well-planned postoperative RT employing a high dose and generous field size can produce high local control rate and remaining urgent problem of distant metastasis demands more effecti distant metastasis demands more effective chemotherapy for the purpose of improving survival of ACC patients

203

Estudo clínico, randomizado, duplo-cego, em crianças com adenóide obstrutiva, submetidas a tratamento homeopático / Prospective, randomized, double-blind clinical trial about efficacy of homeopathic treatment in children with obstructive adenoid  

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Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese OBJETIVO: Avaliar a eficácia e segurança do tratamento homeopático em crianças com adenóide obstrutiva, com indicação cirúrgica. FORMA DE ESTUDO: Clínico prospectivo. Material e método: Estudo prospectivo, duplo-cego, randomizado, em que foram incluídas 40 crianças com idade variando de 3 a 7 anos, [...] 20 crianças foram tratadas com medicação homeopática individualizada (Simillimum), baseada no princípio da similitude e 20 crianças receberam placebo. Todas as crianças do grupo medicação homeopática foram medicadas diariamente com Agraphis nutans 6 CH, Thuya 6 CH e Adenóide 21CH; e as do grupo placebo receberam diariamente medicamentos sem o princípio ativo. A duração do estudo de cada paciente foi de 4 meses. A avaliação dos resultados foi clínica, por meio de questionário padrão, de exame otorrinolaringológico e nasofaringoscopia direta com fibroscópio flexível, no primeiro e no último dia de tratamento. Utilizou-se como critério de inclusão a adenóide que ocupou mais do que 70% da luz coanal. RESULTADOS: Das 20 crianças tratadas com medicamento homeopático, 13 não apresentaram alteração no tamanho da adenóide nos exames nasofaringoscópicos e 7 tiveram diminuição da adenóide; das 20 crianças que receberam placebo por 4 meses, 11 não apresentaram alterações no tamanho da adenóide, 4 tiveram diminuição da adenóide e 5 crianças tiveram aumento. Não houve diferença estatística significante entre os grupos (P= 0,069). Na avaliação clínica da evolução dos pacientes, dos 20 pacientes tratados com medicamento homeopático, 17 se mantiveram inalterados, com respiração oral e ronco, um paciente melhorou, ficando sem ronco e dois foram curados, isto é, a respiração alterou-se de oral para nasal e sem ronco. Dos 20 pacientes tratados com placebo, 17 pacientes se mantiveram inalterados, um paciente melhorou do ronco e dois foram curados, não tendo havido diferença estatística significante entre os grupos (P>0,999). CONCLUSÕES: O tratamento homeopático não foi eficaz nas crianças com adenóide obstrutiva, mantendo-se a indicação cirúrgica em 85% dos pacientes. O medicamento homeopático não provocou eventos adversos nas crianças. Abstract in english AIM: the efficacy and security of homeopathic treatment was investigated on children with obstructive adenoid justifying an operation. STUDY DESIGN: Clinical prospective. MATERIAL AND METHOD: In a prospective, randomized, double-blind clinical trial included 40 children between the ages of 3 to 7 ye [...] ars old, 20 children were treated with homeopathic medication, based in the principle of similarity (Simillimum), and 20 children with placebo. All the children of the homeopathic group/ adenoid, were treated daily with Agraphis nutans 6 CH, Thuya 6 CH and Adenoid 21CH, and the patients of the placebo group received daily placebo medication. The duration of the study of each children was 4 months. The evaluation of the results was clinical, and it was made by questionnaire standard, clinical examination and direct flexible fiberoptic nasopharyngoscopy, in the first and last day of treatment. The criterion of selection was the adenoid that occuped more than 70% of the coanal space. RESULTS: From the group of 20 children treated with homeopathic treatment, 13 did not show any change on the size of adenoid after nasopharyngoscopy, and 7 children had their adenoid decreased; from another group of 20 children that have treated with placebo for 4 months, 11 did not show any change on the size of their adenoid, 4 had their adenoid decreased and 5 had their adenoid increased. The statistical analysis showed a not significant difference (P= 0,069). The clinical evaluation of the patients showed that from the group of 20 patients treated with homeopathy, 17 kept unchanging, with oral breathing and snoring, one patient got better, eliminating the snoring and two were cured, which mean that their oral breathing turned to nasal breathing w

Sergio E., Furuta; Luc L.M., Weckx; Claudia R., Figueiredo.

2003-06-01

204

Carcinoma adenóide cístico: revisão da literatura e relato de caso clínico / Adenoid cystic carcinoma: review of the literature and case report  

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Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese O carcinoma adenóide cístico (CAC) é neoplasia maligna de glândula salivar que acomete principalmente as glândulas parótidas, as submandibulares e as salivares acessórias, sendo raro nas glândulas sublinguais. Com crescimento lento e natureza infiltrativa, clinicamente apresenta-se como nódulo de co [...] nsistência endurecida. O presente trabalho teve como objetivo revisar a literatura atual sobre o tema em relação aos aspectos clínicos e histopatológicos, bem como relatar um caso de CAC na região submandibular. Abstract in english The adenoid cystic carcinoma (ACC) is a malignant neoplasm of salivary gland that arises preferencially in parotid glands, submandibular and minor salivary glands, but is uncommon in sublingual glands. The ACC is a slow growth and infiltrative tumour that clinically is characterized by a firm mass. [...] The present study aims to rewiew the atually literature of the ACC in relation of clinical and histopathological features and describes a case of ACC in submandibular gland.

Adriana Terezinha N. N., Alves; Flávia Dantas, Soares; Arley, Silva Junior; Ney, Medeiros; Adrianna, Milagres.

2004-12-01

205

Carcinoma adenóide cístico: revisão da literatura e relato de caso clínico Adenoid cystic carcinoma: review of the literature and case report  

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Full Text Available O carcinoma adenóide cístico (CAC é neoplasia maligna de glândula salivar que acomete principalmente as glândulas parótidas, as submandibulares e as salivares acessórias, sendo raro nas glândulas sublinguais. Com crescimento lento e natureza infiltrativa, clinicamente apresenta-se como nódulo de consistência endurecida. O presente trabalho teve como objetivo revisar a literatura atual sobre o tema em relação aos aspectos clínicos e histopatológicos, bem como relatar um caso de CAC na região submandibular.The adenoid cystic carcinoma (ACC is a malignant neoplasm of salivary gland that arises preferencially in parotid glands, submandibular and minor salivary glands, but is uncommon in sublingual glands. The ACC is a slow growth and infiltrative tumour that clinically is characterized by a firm mass. The present study aims to rewiew the atually literature of the ACC in relation of clinical and histopathological features and describes a case of ACC in submandibular gland.

Adriana Terezinha N. N. Alves

2004-12-01

206

Incidence of cervical lymph node metastasis and its association with outcomes in patients with adenoid cystic carcinoma. An international collaborative study  

DEFF Research Database (Denmark)

BACKGROUND: The patterns of regional metastasis in adenoid cystic carcinoma (ACC) of the head and neck and its association with outcome is not established. METHODS: We conducted a retrospective multicentered multivariate analysis of 270 patients who underwent neck dissection. RESULTS: The incidence rate of neck metastases was 29%. The rate observed in the oral cavity is 37%, and in the major salivary glands is 19% (p = .001). The rate of occult nodal metastases was 17%. Overall 5-year survival rates were 44% in patients undergoing therapeutic neck dissections, and 65% and 73% among those undergoing elective neck dissections, with and without nodal metastases, respectively (p = .017). Multivariate analysis revealed that the primary site, nodal classification, and margin status were independent predictors of survival. CONCLUSION: Our findings support the consideration of elective neck treatment in patients with ACC of the oral cavity. © 2014 Wiley Periodicals, Inc. Head Neck, 2014.

Amit, Moran; Binenbaum, Yoav

2015-01-01

207

In vitro angiogenesis and expression of nuclear factor ?B and VEGF in high and low metastasis cell lines of salivary gland Adenoid Cystic Carcinoma  

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Full Text Available Abstract Background Adenoid cystic carcinoma is a high malignant carcinoma characterized by intensive local invasion and high incidence of distant metastasis. Although many reports have demonstrated that angiogenesis has played an important role in tumor metastasis, the relationship between metastasis characters and angiogenesis ability in high and low metastasis cell lines of Adenoid cystic carcinoma has rarely been reported. The present study aimed to compare the angiogenesis ability of ACC-M (high metastasis and ACC-2 (low metastasis cell lines in vitro. Furthermore, the activity of nuclear factor ?appa B and the expression of vascular endothelial growth factor (VEGF in ACC-2 and ACC-M were also detected. Methods Electrophoretic mobility shift assay was used to detect nuclear factor ?appa B activity. Semi-quantitative RT-PCR was used to quantify the mRNA level of VEGF. Immuofluorescence double staining and semi-quantitative confocal laser scanning analysis was carried out to detect nuclear factor ?appa B nuclear localization and staining intensity of VEGF. The angiogenesis ability of ACC-M and ACC-2 was compared by an in vitro three-dimensional angiogenic model assay. The vector transfection assay was performed to transfect the PCMV-I?B?M vector into ACCs cell lines expressing the phosphorylation defective I?B?M. Results Nuclear factor ?appa B activity and the rate of nuclear factor ?appa B nuclear localization in ACC-M was significantly higher than that in ACC-2. Moreover, ACC-M exhibited higher mRNA and protein levels of vascular endothelial growth factor than ACC-2. VEGF mRNA expression was effectively decreased by inhibition of nuclear factor ?appa B activity. Furthermore, ACC-M could remarkably stimulate the migration and tube formation of endothelial cells and induce The umbilical vein endothelial cells sprouting into the gel matrix. Conclusion These results implicated that ACCs cells with higher metastasis feature might present greater angiogenesis ability.

Peng Bin

2007-06-01

208

Tonsils and Adenoids  

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... When the patient arrives at the hospital or surgery center, the anesthesiologist and nursing staff may meet with the patient and family to review the patient?s history. The patient will then be taken to the ... and after surgery. After the operation, the patient will be taken ...

209

Estudo comparativo radiológico e nasofibroscópico do volume adenoideano em crianças respiradoras orais / Comparison between radiological and nasopharyngolaryngoscopic assessment of adenoid tissue volume in mouth breathing children  

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Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese A tonsila faríngea ou adenóides é a extensão superior do anel linfático de Waldeyer e está localizada na porção alta da cavidade nasofaríngea, próxima à tuba auditiva e à coana. Ela desempenha um papel relevante nas otites médias recorrentes e freqüentemente sua hipertrofia é responsável pela obstru [...] ção das vias aéreas superiores. A tonsilectomia é um tratamento comumente realizado para doenças crônicas das tonsilas e ainda é o procedimento cirúrgico mais freqüente e mais antigo realizado em crianças e adultos jovens. Os critérios para a realização da tonsilectomia, o efeito da mesma na integridade imunológica do paciente e seus riscos inerentes à cirurgia são muito discutíveis e controversos em todo o mundo. Estudos de imagem utilizando-se o raio-X do cavo é um método simples, fácil e confortável para avaliar o tamanho das adenóides e o grau de obstrução das vias aéreas superiores. Um estudo nasofibroscópico da nasofaringe pode fornecer uma informação melhor sobre essa região, tendo em vista que ele mostra todas as estruturas presentes na nasofaringe e o grau de obstrução das vias aéreas superiores de forma dinâmica. FORMA DE ESTUDO: Clínico não randomizado. MATERIAL E MÉTODO: Este estudo comparou o grau de hipertrofia e de obstrução das vias aéreas superiores, usando os dois métodos acima, em crianças de 3 a 10 anos de idade, constatando que a nasofibroscopia flexível é um método diagnóstico excepcionalmente mais fidedigno do que o raio-x do cavo, na avaliação volumétrica da adenóide. Abstract in english The pharyngeal tonsil (adenoid) constitutes the upper portion of the Waldeyer's ring and is located at the top of the nasopharynx, next to the auditory tube and choana. It plays an important role in recurrent otitis of the middle ear and many times its enlargement is responsible for upper airway obs [...] truction. Tonsillectomy is often the treatment of choice for tonsillar diseases. So far, it is the most frequent and one of the oldest surgical procedures performed in children and young adults. The criteria for tonsillectomy, its effect on patient's immunological integrity and the surgical risks are widely controversial. Image study using paranasal sinuses x-ray is a very simple, easy and comfortable method to evaluate the sizes of adenoids and the grade of upper airway obstruction. Cohen et al. supported that paranasal sinuses x-ray is the best way to determine pharyngeal tonsil hypertrophy. On the other hand, nasopharyngolaryngoscopy can provide more accurate data on the nasopharynx, as it can dynamically reveal its structures and the obstruction status of the upper airway. This study compared the grade of adenoid hypertrophy, as well as upper airway obstruction, using the above-mentioned approaches in children ranging from 3 to 10 years old. The study came to the conclusion that nasopharyngolaryngoscopy is a much more accurate diagnostic procedure than radiological evaluation of the nasopharynx.

Edmir Américo, Lourenço; Karen de Carvalho, Lopes; Álvaro, Pontes Jr.; Marcelo Henrique de, Oliveira; Adriana, Umemura; Ana Laura, Vargas.

2005-02-01

210

The influence of positive margins and nerve invasion in adenoid cystic carcinoma of the head and neck treated with surgery and radiation  

International Nuclear Information System (INIS)

Purpose: Surgery is the primary treatment for adenoid cystic carcinomas arising from major and minor salivary glands of the head and neck. However, local recurrence is frequent because of the infiltrative growth pattern and perineural spread associated with these tumors. At UTMDACC, we have had a long-standing policy of using postoperative radiotherapy to reduce the risk of local recurrence and to avoid the need for radical surgery; this 30-year retrospective study analyzes the results of this combined modality approach. Methods and Materials: Between 1962 and 1991, 198 patients ages 13-82 years, with adenoid cystic carcinomas of the head and neck, received postoperative radiotherapy for known or suspected microscopic residual disease following surgery. Distribution of primary sites was: parotid: 30 patients; submandibular/sublingual: 41 patients; lacrimal: 5 patients; and minor salivary glands: 122 patients. Eighty-three patients (42%) had microscopic positive margins and an additional 55 (28%) had close (?5 mm) or uncertain margins. One hundred thirty-six patients (69%) had perineural spread with invasion of a major (named) nerve in 55 patients (28%). Using radiation techniques appropriate to the primary site, a median dose of 60 Gy (range 50-69 Gy) was delivered to the tumor bed. Follow-up ranged from 5-341 months (median, 93 months). All surviving patients had a minimum of 2 years follow-up. Results: Twenty-three patients (12%) had local recurrences with 5-, 10-(12%) had local recurrences with 5-, 10-, and 15-year actuarial local control rates of 95%, 86%, and 79%, respectively. Fifteen of the 83 patients (18%) with positive margins developed local recurrences, compared to 5 of 55 patients (9%) with close or uncertain margins, and 3 of 60 patients (5%) with negative margins (p 0.02). Patients with and without a major (named) nerve involved had crude failure rates of 18% (10 out of 55) and 9% (13 out of 143), respectively (p 0.02). There was a trend toward better local control with increasing dose. This was significant in patients with positive margins, in whom crude control rates were 40 and 88% for doses of <56 Gy and ?56 Gy, respectively (p 0.006). Actuarial 5-, 10-, and 15-year freedom from relapse rates were 68%, 52%, and 45%, respectively. Base of skull and neck failures were uncommon with or without elective treatment, developing in 2 and 3% of patients, respectively. Distant metastases were the most common type of disease recurrence, developing in 74 patients (37%) of whom 62 (31%) were disease-free at the primary site. Conclusions: Excellent local control rates were obtained in this population using surgery and postoperative radiotherapy and we recommend this combined approach for most patients with adenoid cystic carcinomas of the head and neck. Perineural invasion was an adverse prognostic factor only when a major (named) nerve was involved. Microscopic positive margins was also an adverse prognostic factor, but even when present, local control was achieved in over 80% of our patients. We recommend a dose of 60 Gy to the tumor bed, supplemented to 66 Gy for patients with positive margins. Despite effective local therapy, one-third of patients fail systemically, and good treatment to address this problem is lacking

211

Estudo comparativo radiológico e nasofibroscópico do volume adenoideano em crianças respiradoras orais Comparison between radiological and nasopharyngolaryngoscopic assessment of adenoid tissue volume in mouth breathing children  

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Full Text Available A tonsila faríngea ou adenóides é a extensão superior do anel linfático de Waldeyer e está localizada na porção alta da cavidade nasofaríngea, próxima à tuba auditiva e à coana. Ela desempenha um papel relevante nas otites médias recorrentes e freqüentemente sua hipertrofia é responsável pela obstrução das vias aéreas superiores. A tonsilectomia é um tratamento comumente realizado para doenças crônicas das tonsilas e ainda é o procedimento cirúrgico mais freqüente e mais antigo realizado em crianças e adultos jovens. Os critérios para a realização da tonsilectomia, o efeito da mesma na integridade imunológica do paciente e seus riscos inerentes à cirurgia são muito discutíveis e controversos em todo o mundo. Estudos de imagem utilizando-se o raio-X do cavo é um método simples, fácil e confortável para avaliar o tamanho das adenóides e o grau de obstrução das vias aéreas superiores. Um estudo nasofibroscópico da nasofaringe pode fornecer uma informação melhor sobre essa região, tendo em vista que ele mostra todas as estruturas presentes na nasofaringe e o grau de obstrução das vias aéreas superiores de forma dinâmica. FORMA DE ESTUDO: Clínico não randomizado. MATERIAL E MÉTODO: Este estudo comparou o grau de hipertrofia e de obstrução das vias aéreas superiores, usando os dois métodos acima, em crianças de 3 a 10 anos de idade, constatando que a nasofibroscopia flexível é um método diagnóstico excepcionalmente mais fidedigno do que o raio-x do cavo, na avaliação volumétrica da adenóide.The pharyngeal tonsil (adenoid constitutes the upper portion of the Waldeyer's ring and is located at the top of the nasopharynx, next to the auditory tube and choana. It plays an important role in recurrent otitis of the middle ear and many times its enlargement is responsible for upper airway obstruction. Tonsillectomy is often the treatment of choice for tonsillar diseases. So far, it is the most frequent and one of the oldest surgical procedures performed in children and young adults. The criteria for tonsillectomy, its effect on patient's immunological integrity and the surgical risks are widely controversial. Image study using paranasal sinuses x-ray is a very simple, easy and comfortable method to evaluate the sizes of adenoids and the grade of upper airway obstruction. Cohen et al. supported that paranasal sinuses x-ray is the best way to determine pharyngeal tonsil hypertrophy. On the other hand, nasopharyngolaryngoscopy can provide more accurate data on the nasopharynx, as it can dynamically reveal its structures and the obstruction status of the upper airway. This study compared the grade of adenoid hypertrophy, as well as upper airway obstruction, using the above-mentioned approaches in children ranging from 3 to 10 years old. The study came to the conclusion that nasopharyngolaryngoscopy is a much more accurate diagnostic procedure than radiological evaluation of the nasopharynx.

Edmir Américo Lourenço

2005-02-01

212

Avaliação da pressão inspiratória em crianças com aumento do volume de tonsilas / Evaluation of inspiratory pressure in children with enlarged tonsils and adenoids  

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Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese Crianças com aumento do volume de tonsilas palatina e faríngea freqüentemente apresentam anormalidades respiratórias tais como ronco, respiração oral e apnéia do sono. Sabe-se que a obstrução de vias aéreas superiores e conseqüentemente a respiração oral podem resultar em problemas pulmonares. OBJET [...] IVO: Avaliar a pressão inspiratória em crianças com obstrução de vias aéreas superiores devido ao aumento do volume de tonsilas. FORMA DE ESTUDO: clínico com coorte transversal. MATERIAL E MÉTODO: Nós avaliamos 37 crianças (4-13 anos, ambos os sexos) com aumento do volume de tonsilas que seriam submetidas à cirurgia de Adenoamigdalectomia na Divisão de Otorrinolaringologia da Universidade de São Paulo no mesmo período. O grupo controle foi composto de 28 crianças sem aumento de volume tonsilar que foram submetidas aos mesmos testes. A pressão Inspiratória foi obtida pelo uso do manovacuômetro. RESULTADOS: Observamos uma menor pressão inspiratória no grupo com aumento do volume de tonsilas. A média do grupo com aumento do volume das tonsilas foi 14,607 cm/H2O e do grupo normal foi de 27,580 cm/H2O (P Abstract in english Children with enlarged tonsils and adenoids usually present breathing abnormalities such as snoring, mouth breathing and sleep apnea. It is known that upper airway obstruction and consequent mouth breathing may result in pulmonary diseases. AIM: The goal of this preliminary study was to evaluate the [...] inspiratory pressure in children with upper airway obstruction due to enlarged tonsils. STUDY DESIGN: clinical with transversal cohort. MATERIAL AND METHOD: We evaluated 37 children (4 -13 years old, female/male) with enlarged tonsils who would be submitted to a T&A surgery in the Department of Otolaryngology, Medical School, University of Sao Paulo, from October 2002 to March 2003. The control group comprised 28 children without tonsillar disease submitted to the same tests. Inspiratory pressure was obtained using a manometer and vacuum meter. RESULTS: We could observe lower inspiratory pressures in children with upper airway obstruction. The mean of inspiratory pressure in the upper airway obstruction group was 14.607cm/H2O and in the control group was of 27.580cm/H2O. CONCLUSIONS: Enlarged tonsils and adenoids were associated with poor inspiratory pressure, resulting in increased breathing effort and work of the involved muscles.

Melissa Guerato, Pires; Renata Cantisani, Di Francesco; Anete Sevciovic, Grumach; João Ferreira de, Mello Jr..

2005-10-01

213

Avaliação da pressão inspiratória em crianças com aumento do volume de tonsilas Evaluation of inspiratory pressure in children with enlarged tonsils and adenoids  

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Full Text Available Crianças com aumento do volume de tonsilas palatina e faríngea freqüentemente apresentam anormalidades respiratórias tais como ronco, respiração oral e apnéia do sono. Sabe-se que a obstrução de vias aéreas superiores e conseqüentemente a respiração oral podem resultar em problemas pulmonares. OBJETIVO: Avaliar a pressão inspiratória em crianças com obstrução de vias aéreas superiores devido ao aumento do volume de tonsilas. FORMA DE ESTUDO: clínico com coorte transversal. MATERIAL E MÉTODO: Nós avaliamos 37 crianças (4-13 anos, ambos os sexos com aumento do volume de tonsilas que seriam submetidas à cirurgia de Adenoamigdalectomia na Divisão de Otorrinolaringologia da Universidade de São Paulo no mesmo período. O grupo controle foi composto de 28 crianças sem aumento de volume tonsilar que foram submetidas aos mesmos testes. A pressão Inspiratória foi obtida pelo uso do manovacuômetro. RESULTADOS: Observamos uma menor pressão inspiratória no grupo com aumento do volume de tonsilas. A média do grupo com aumento do volume das tonsilas foi 14,607 cm/H2O e do grupo normal foi de 27,580 cm/H2O (PChildren with enlarged tonsils and adenoids usually present breathing abnormalities such as snoring, mouth breathing and sleep apnea. It is known that upper airway obstruction and consequent mouth breathing may result in pulmonary diseases. AIM: The goal of this preliminary study was to evaluate the inspiratory pressure in children with upper airway obstruction due to enlarged tonsils. STUDY DESIGN: clinical with transversal cohort. MATERIAL AND METHOD: We evaluated 37 children (4 -13 years old, female/male with enlarged tonsils who would be submitted to a T&A surgery in the Department of Otolaryngology, Medical School, University of Sao Paulo, from October 2002 to March 2003. The control group comprised 28 children without tonsillar disease submitted to the same tests. Inspiratory pressure was obtained using a manometer and vacuum meter. RESULTS: We could observe lower inspiratory pressures in children with upper airway obstruction. The mean of inspiratory pressure in the upper airway obstruction group was 14.607cm/H2O and in the control group was of 27.580cm/H2O. CONCLUSIONS: Enlarged tonsils and adenoids were associated with poor inspiratory pressure, resulting in increased breathing effort and work of the involved muscles.

Melissa Guerato Pires

2005-10-01

214

Co-existing adenoid cystic carcinoma and invasive squamous cell carcinoma of the uterine cervix: a rare case report and literature review.  

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Adenoid cystic carcinoma (ACC) is a rare cervical malignancy, and its coexistence with other malignancies in the uterine cervix is extremely rare. Here, we present a case of coexistence of ACC and invasive squamous cell carcinoma (SCC) of the uterine cervix, as well as a literature review. A 68-year-old Chinese woman with vaginal bleeding underwent a cervical cytology screening, cervical biopsy, and finally cervical conization. Subsequent pathological diagnoses of coexisting ACC and invasive SCC were rendered with a positive margin. Her status post-radiation therapy showed no recurrence or metastasis after a follow-up of 7 months. Immunohistochemical studies of the surgical specimen revealed that the ACC component exhibited a pattern distinct from the SCC component. ACC was collagen IV, S-100 and CK7 positive, and p63 and CK34?E12 (CK903) patchy positive; SCC was p63 and CK34?E12 (CK903) strongly and diffusely positive, while negative for collagen IV, S-100, and CK7. Both components were positive for high-risk human papilloma virus types 16 and 18, detected by in situ hybridization. This case is among very few previously described cases of coexisting ACC with invasive SCC in the uterine cervix. PMID:25361940

Shi, Xiaohua; Chang, Xiaoyan; Wu, Huanwen; Ren, Xinyu; Liu, Tonghua; Bui, Marilyn M

2014-01-01

215

Clinicopathologic predictors of recurrence and overall survival in adenoid cystic carcinoma of the head and neck: A single institutional experience at a tertiary care center  

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Background The purpose of this study was to determine factors that impact recurrence and long-term survival of head and neck adenoid cystic carcinoma (ACC). Methods We conducted a retrospective review of 87 patients with head and neck ACC who were evaluated between 1992 and 2009. Staining for Ki-67, p53, ?-estrogen receptor (?ER), and progesterone receptor (PR) was performed. Results Forty men (46%) and 47 women (54%) were included in this study. Median follow-up for patients was 98 months. Five-year recurrence-free and overall survival (OS) rates were 56% and 81%, respectively. Ki-67 and p53 expression was observed in 5 (6%) and 2 (2%) patients, respectively. ?ER and PR were all negative. The most important determinants of disease-free survival (DFS) were perineural invasion (PNI; p = .001) and female sex (p = .027). Disease site (major vs minor salivary gland) was the only predictor of worse OS on multivariate analysis. Conclusion Perineural invasion, female sex, and disease site were the most consistent predictors of poor outcome in head and neck ACC. PMID:24166847

Marcinow, Anna; Ozer, Enver; Teknos, Theodoros; Wei, Lai; Hurtuk, Agnes; Old, Matthew; Agrawal, Amit; Carrau, Ricardo; Iwenofu, Obiajulu H.

2015-01-01

216

Management of salivary gland adenoid cystic carcinoma: institutional experience of a case series / Conduta no carcinoma adenóide cístico de glândula salivar: série de casos em experiência institucional  

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Full Text Available SciELO Brazil | Language: English Abstract in portuguese CONTEXTO E OBJETIVO: Tumores de glândulas salivares exigem acompanhamento clínico por longos períodos devido à evolução indolente dessas neoplasias e à possibilidade tardia de recidivas locais e metástases a distância. O carcinoma adenóide cístico (CAC) compreende 10% a 15% dos tumores de glândulas [...] salivares. O objetivo deste trabalho é analisar a conduta terapêutica, o estadiamento e o acompanhamento de pacientes com CAC em cabeça e pescoço em instituição de ensino. TIPO DE ESTUDO E LOCAL: Estudo retrospectivo realizado no Serviço de Cirurgia de Cabeça e Pescoço, Universidade Estadual de Campinas. MÉTODOS: Revemos o tratamento do CAC de 21 pacientes tratados entre 1993 e 2003. Os pacientes foram estadiados conforme os critérios clínicos da União Internacional Contra o Câncer (UICC) de 1998 e o tratamento foi baseado na avaliação clínica e imagenológica. RESULTADOS: 11 tumores estavam localizados nas glândulas salivares maiores (52,3%), sendo sete em glândula submandibular e quatro em parótida. Em 10 pacientes (47,7%), os tumores estavam em glândulas salivares menores (todos em palato). Quando ocorreram em glândula salivar maior, a submandibular foi a mais acometida. O diagnóstico foi realizado quase sempre por punção aspirativa por agulha fina (PAAF) ou biópsia. Biópsia por congelação no intraoperatório foi realizada em seis pacientes. Obtivemos boa correlação entre o ultra-som e a PAAF. Em 16 pacientes (76%), a radioterapia pós-operatória foi realizada. Um dos pacientes (4,7%) foi a óbito pelo CAC e cinco tiveram recidivas da doença, sendo três locoregionais (14,2%) e dois (9,5%) por metástases a distância. CONCLUSÃO: Carcinoma adenóide cístico apresenta comportamento agressivo localizado. Em 21 casos, o nervo facial foi preservado, exceto nos raros pacientes com invasão grosseira pelo tumor. O tratamento baseou-se no exame físico, exames de imagem, estágio do tumor e diferenciação histológica. Abstract in english CONTEXT AND OBJECTIVE: Salivary gland tumor management requires long-term follow-up because of tumor indolence and possible late recurrence and distant metastasis. Adenoid cystic carcinoma (ACC) accounts for 10-15% of such tumors. The aim here was to evaluate surgical and clinical management, stagin [...] g and follow-up of ACC patients in one academic institution. DESIGN AND SETTING: Retrospective study at Head and Neck Service, Universidade Estadual de Campinas. METHODS: Data on 21 patients treated between 1993 and 2003 were reviewed. Management utilized clinical staging, histology and imaging. Major salivary gland tumor extent was routinely assessed by preoperative ultrasonography. Diagnosis, surgery type, margin type (negative/positive), postoperative radiotherapy and recurrence (presence/absence) were evaluated. RESULTS: There were eleven major salivary gland tumors (52.3%), seven submandibular and four parotid. Ten patients (47.7%) had minor salivary gland ACC (all in palate), while the submandibular was the most frequently affected major one. Diagnoses were mostly via fine-needle aspiration (FNA) and incision biopsy. Frozen sections were used for six patients. There was good ultrasound/FNA correlation. Sixteen (76%) had postoperative radiotherapy. One (4.7%) died from ACC and five now have recurrent disease: three (14.2%) locoregional and two (9.5%) distant metastases. CONCLUSION: Adenoid cystic carcinoma has locally aggressive behavior. In 21 cases, of ACC, the facial nerve was preserved in all except in the few with gross tumor involvement. Treatment was defined from physical examination, imaging, staging and histology.

Alfio José, Tincani; André, Del Negro; Priscila Pereira Costa, Araújo; Hugo Kenzo, Akashi; Antonio Santos, Martins; Albina Milani, Altemani; Gilson, Barreto.

2006-02-01

217

c-Kit Expression is Rate-Limiting for Stem Cell Factor-Mediated Disease Progression in Adenoid Cystic Carcinoma of the Salivary Glands.  

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Adenoid cystic carcinoma (ACC) is an aggressive malignant neoplasm of the salivary glands in which c-Kit is overexpressed and activated, although the mechanism for this is as yet unclear. We analyzed 27 sporadic ACC tumor specimens to examine the biologic and clinical significance of c-Kit activation. Mutational analysis revealed expression of wild-type c-Kit in all, eliminating gene mutation as a cause of activation. Because stem cell factor (SCF) is c-Kit's sole ligand, we analyzed its expression in the tumor cells and their environment. Immunohistochemistry revealed its presence in c-Kit-positive tumor cells, suggesting an activation of autocrine signaling. We observed a significant induction of ERK1/2 in the cells. SCF staining was also found in other types of non-cancerous cells adjacent to tumors within salivary glands, including stromal fibroblasts, neutrophils, peripheral nerve, skeletal muscle, vascular endothelial cells, mucous acinar cells, and intercalated ducts. Quantitative PCR showed that the top quartile of c-Kit mRNA expression distinguished ACCs from normal salivary tissues and was cross-correlated with short-term poor prognosis. Expression levels of SCF and c-Kit were highly correlated in the cases with perineural invasion. These observations suggest that c-Kit is potentially activated by receptor dimerization upon stimulation by SCF in ACC, and that the highest quartile of c-Kit mRNA expression could be a predictor of poor prognosis. Our findings may support an avenue for c-Kit-targeted therapy to improve disease control in ACC patients harboring the top quartile of c-Kit mRNA expression. PMID:25389449

Phuchareon, Janyaporn; van Zante, Annemieke; Overdevest, Jonathan B; McCormick, Frank; Eisele, David W; Tetsu, Osamu

2014-10-01

218

MYB-NFIB gene fusion in adenoid cystic carcinoma of the breast with special focus paid to the solid variant with basaloid features.  

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Adenoid cystic carcinomas (ACCs) from various anatomical sites harbor a translocation t(6;9)(q22-23;p23-24), resulting in MYB-NFIB gene fusion. This gene fusion is not well studied in mammary ACCs, and there are no studies examining this abnormality in solid variant of ACC with basaloid features (SBACC), a high-grade variant thought to behave more aggressively than ACCs with conventional histologic growth. Our aim was to investigate the frequency of MYB-NFIB gene fusion in mammary ACCs with a focus paid to SBACC. MYB rearrangement and MYB-NFIB fusion were assessed by fluorescence in situ hybridization and reverse-transcription polymerase chain reaction, respectively. Histologic features and the presence of MYB rearrangement were correlated with clinical outcome. MYB rearrangement was present in 7 (22.6%) of 31 mammary ACCs (5/15 [33.3%] ACCs with conventional growth; 2/16 [12.5%] SBACCs). One patient with conventional ACC developed distant metastasis, and no patients had axillary lymph node involvement by ACC (mean follow-up, 34 months; range, 12-84 months). Two patients with SBACC had axillary lymph node involvement at initial surgery, and 2 additional patients experienced disease recurrence (1 local, 1 distant; mean follow-up, 50 months; range, 9-192 months). MYB-NFIB fusion status did not correlate with clinical outcome in studied patients. We confirm that MYB-NFIB gene fusion is observed in mammary ACCs and that a subset lacks this abnormality. This study is the first to confirm the presence of MYB rearrangement in SBACC. Additional validation with long-term follow-up is needed to determine the relationship, if any, between MYB-NFIB gene fusion and clinical outcome. PMID:25217885

D'Alfonso, Timothy M; Mosquera, Juan Miguel; MacDonald, Theresa Y; Padilla, Jessica; Liu, Yi-Fang; Rubin, Mark A; Shin, Sandra J

2014-11-01

219

Expression of beclin 1 in primary salivary adenoid cystic carcinoma and its relation to Bcl-2 and p53 and prognosis  

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Full Text Available SciELO Brazil | Language: English Abstract in english Beclin 1 plays a critical role in autophagy and functions as a haploinsufficient tumor suppressor. The expression and prognostic significance of beclin 1 in head and neck adenoid cystic carcinoma (ACC) are largely unexplored. Therefore, we investigated the expression of beclin 1, Bcl-2, and p53 in [...] head and neck ACC tissue. Tissue samples from 35 cases (15 females, 20 males) of head and neck ACC were utilized for immunohistochemistry. Beclin 1 expression was observed in 32 cases (91.4%) and considered to be high in 15 cases (42.9%) and low in 20 cases (57.1%). Beclin 1 expression was significantly correlated with a histological growth pattern (P=0.046) and histological grade (P=0.037). Beclin 1 expression was inversely correlated with Bcl-2 expression (P=0.013) and significantly associated with overall survival (P=0.006). Bcl-2 and p53 expression were observed in 21 cases (60.0%) and 16 cases (45.7%). Bcl-2 expression was significantly correlated with perineural invasion (P=0.041) and not associated with overall survival (P=0.053). p53 expression was directly correlated with beclin 1 expression (P=0.044). Our results indicated that beclin 1 may be a novel, promising prognostic factor for clinical outcome in head and neck ACC patients and may play a part in the development of head and neck ACC by interacting with Bcl-2 and p53.

L.C., Jiang; S.Y., Huang; D.S., Zhang; S.H., Zhang; W.G., Li; P.H., Zheng; Z.W., Chen.

2014-03-01

220

Mutations in the c-Kit Gene Disrupt Mitogen-Activated Protein Kinase Signaling during Tumor Development in Adenoid Cystic Carcinoma of the Salivary Glands  

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Full Text Available The Ras/mitogen-activated protein kinase (MAPK pathway is considered to be a positive regulator of tumor initiation, progression, and maintenance. This study reports an opposite finding: we have found strong evidence that the MAPK pathway is inhibited in a subset of adenoid cystic carcinomas (ACCs of the salivary glands. ACC tumors consistently overexpress the receptor tyrosine kinase (RTK c-Kit, which has been considered a therapeutic target. We performed mutational analysis of the c-Kit gene (KIT in 17 cases of ACC and found that 2 cases of ACC had distinct missense mutations in KIT at both the genomic DNA and messenger RNA levels. These mutations caused G664R and R796G amino acid substitutions in the kinase domains. Surprisingly, the mutations were functionally inactive in cultured cells. We observed a significant reduction of MAPK (ERK1/2 activity in tumor cells, as assessed by immunohistochemistry. We performed further mutational analysis of the downstream effectors in the c-Kit pathway in the genes HRAS, KRAS, NRAS, BRAF, PIK3CA, and PTEN. This analysis revealed that two ACC tumors without KIT mutations had missense mutations in either KRAS or BRAF, causing S17N K-Ras and V590I B-Raf mutants, respectively. Our functional analysis showed that proteins with these mutations were also inactive in cultured cells. This is the first time that MAPK activity from the RTK signaling has been shown to be inhibited by gene mutations during tumor development. Because ACC seems to proliferate despite inactivation of the c-Kit signaling pathway, we suggest that selective inhibition of c-Kit is probably not a suitable treatment strategy for ACC.

Osamu Tetsu

2010-09-01

221

Sinonasal tract adenoid cystic carcinoma ex-pleomorphic adenoma: a clinicopathologic and immunophenotypic study of 9 cases combined with a comprehensive review of the literature.  

Science.gov (United States)

Primary sinonasal tract carcinoma ex-pleomorphic adenoma (CEPA) is very uncommon, with adenoid cystic carcinoma (ACC) CEPA exceptional. These tumors are often misclassified. This is a retrospective study. Nine cases of ACC CEPA included 7 females and 2 males, aged 39-64 years (mean, 51.1 years). Patients presented most frequently with obstructive symptoms (n = 5), epistaxis (n = 3), nerve changes or pain (n = 3), present for a mean of 25 months (men: 9.5 versus women: 29.4 months; p = 0.264). The tumors involved the nasal cavity alone (n = 5), nasopharynx (n = 2), or a combination of locations (n = 2) with a mean size of 2.9 cm (females: 3.3; males: 1.7; p = 0.064). Most patients presented at a low clinical stage (n = 7, stage I), with one patient each in stage II and IV, respectively. Histologically, the tumors showed foci of PA associated with areas of ACC. Tumors showed invasion (lymph-vascular: n = 4; perineural: n = 6; bone: n = 6). The neoplastic cells were arranged in tubules, cribriform and solid patterns, with peg-shaped cells arranged around reduplicated basement membrane and glycosaminoglycan material. Mitoses ranged from 0 to 33, with a mean of 8.7 mitoses/10 HPFs. Necrosis (n = 2) and atypical mitotic figures (n = 1) were seen infrequently. Immunohistochemical studies showed positive reactions for cytokeratin, CK5/6, p63, CK7, EMA, SMA, calponin, S100 protein and CD117, several highlighting luminal versus basal cells components. GFAP, CK20 and MSA were non-reactive. p53 and Ki-67 were reactive to a variable degree. Surgery (n = 8), accompanied by radiation therapy (n = 5) was generally employed. Five patients developed a recurrence, all of whom died with disease (mean, 8.4 years), while 4 patients are either alive (n = 2) or had died (n = 2) without evidence of disease (mean, 15.9 years). In summary, ACC CEPA probably arises from the minor mucoserous glands of the upper aerodigestive tract, usually presenting in patients in middle age with obstructive symptoms in a nasal cavity based tumor. Most patients present with low stage disease (stage I and II), although invasive growth is common. Recurrences develop in about a 55 % of patients, who experience a shorter survival (mean, 8.4 years) than patients without recurrences (mean, 15.9 years). The following parameters, when present, suggest an increased incidence of recurrence or dying with disease: bone invasion, lymph-vascular invasion, and perineural invasion. PMID:22941242

Toluie, Sherwin; Thompson, Lester D R

2012-12-01

222

Tratamiento quirúrgico del carcinoma adenoideo quístico de la tráquea: Presentación de un caso y revisión de la literatura / Surgical treatment of adenoid cystic carcinoma of the trachea: Report of a case and review of the literature  

Scientific Electronic Library Online (English)

Full Text Available SciELO Mexico | Language: Spanish Abstract in spanish Introducción: Los tumores malignos primarios de tráquea son raros, en el adulto representan el 90% de todos los tumores traqueales. El carcinoma adenoideo quístico es el segundo más frecuente con aproximadamente del 10-15% de los casos. Los síntomas son inespecíficos y los más frecuentes suelen ser: [...] tos, ronquera, disnea, sibilancias y estridor. La broncoscopia es el método para la obtención de tejido para el estudio histológico. La resección quirúrgica es el tratamiento de elección siempre que sea posible. Métodos: Se presenta el caso de una mujer de 59 años de edad con diagnóstico de carcinoma adenoideo quístico en tercio medio de la tráquea, a quien se le realizó resección traqueal con anastomosis terminoterminal, obteniendo resección completa, no recibió adyuvancia, con seguimiento de 15 meses sin recurrencia. Discusión y conclusiones: El manejo de pacientes con carcinoma adenoideo quístico debe ser multidisciplinario. A la paciente se le pronosticó una tasa de sobrevida a 5 años de 91% por tratarse de una enfermedad localizada. El diagnóstico de este tipo de tumores tiene un subregistro y el manejo quirúrgico está subutilizado en México. Los pacientes con este tipo de tumores, en particular, y todos los tumores traqueales, en general, deben ser referidos a centros con experiencia para el manejo de patología traqueal. Abstract in english Introduction: Primary malignant tumors of the trachea are rare, but they represent 90% of all tumors of the trachea. The adenoid cystic carcinoma is the second most frequent hystologic type of tumor growing in the trachea with aproximately 10 to 15% of all cases. Symptoms are unspecific and the most [...] frequent are cough, hoarseness, dyspnea, wheezzing and stridor. Bronchoscopy is the study of choice to obtain tissue for histopathologic study. Surgery is the treatment of choice when possible. Methods: We present the case of a 59 years old female with an adenoid cystic carcinoma of the middle third of the trachea, treated with surgical resection, obtaining a complete resection, with no adyuvant therapy, and with 14 months follow-up without recurrence. Discussion and conclusions: Treatment of adenoid cystic carcinoma should be multidisciplinary. In our patient had forecast a rate of 5-year survival of 91% because it was a localized disease. We consider that patients with any type of tracheal tumor should be referred to a specialized center with experience in the treatment of tracheal pathology.

Marco Antonio, Iñiguez-García; Enrique, Guzmán-de-Alba; César, Luna-Rivero; Gustavo Félix, Salazar-Otaola; Carlos Manuel, Núñez-Bustos; Juan Carlos, Vázquez-Minero.

2014-06-01

223

Pemphigoïde bulleuse révélant un carcinome bronchique  

Science.gov (United States)

La pemphigoïde bulleuse (PB) est la plus fréquente des dermatoses bulleuses auto-immunes, touchants préférentiellement le sujet âgé de plus de 70 ans. L'origine paranéoplasique de La PB est rarement rapportée. Cette lésion peut apparaitre de manière synchrone ou parfois être une manifestation révélatrice de la tumeur. Nous rapportons l'observation d'un jeune patient présentant un cancer bronchique métastatique révélé par une PB. Chez le sujet jeune fumeur, toute pemphigoïde bulleuse justifie la recherche d'une néoplasie. PMID:25667707

Janah, Hicham; Mahhou, Meryem; Souhi, Hicham; Zegmout, Adil; Naji-Amrani, Hicham; Raoufi, Mohamed; Elouazzani, Hanane; Rhorfi, Ismail Abderrahmani; Abid, Ahmed

2014-01-01

224

Thomsen-Friedenreich (T) antigen as marker of myoepithelial and basal cells in the parotid gland, pleomorphic adenomas and adenoid cystic carcinomas. An immunohistological comparison between T and sialosyl-T antigens, alpha-smooth muscle actin and cytokeratin 14  

DEFF Research Database (Denmark)

Controversy centres on the role and identification of myoepithelial (MEC) and basal cells in salivary gland tumours, and recent studies suggest that both basal cells and myoepithelial cells participate in the formation of salivary gland tumours. We have correlated the expression of different well-known markers of normal MEC/basal cells (i.e. alpha-smooth muscle actin and cytokeratin 14) with T (Thomsen-Friedenreich) antigen and its sialylated derivative: sialosyl-T antigen,) in 17 normal parotid glands and in two tumour types with MEC participation (i.e pleomorphic adenomas (PA) and adenoid cystic carcinomas (ACC)) using immunohistology with well-defined monoclonal antibodies (MAbs). Paraffin-embedded/fresh frozen tissue sections were studied from 33/17 patients with PA and 15/7 patients with ACC. In normal parotid tissue coexpression of alpha-smooth muscle actin, cytokeratin 14, T and sialosyl-T antigens was found in all MEC and in some of the basal cells lining striated ducts. The remaining basal cells exclusively expressed cytokeratin 14, T and sialosyl-T antigens. In the tumours, cells believed to be modified myoepithelial cells showed two different staining patterns: 1) Coexpression of alpha-smooth muscle actin, cytokeratin 14, T and sialosyl-T antigens, and 2) Coexpression of cytokeratin 14, T and sialosyl-T antigens, but no alpha-smooth muscle actin. The epithelial ductular structures in the tumours showed aberrant expression of cytokeratin 14, T and sialosyl-T antigens, and cytokeratin 14 was the only marker of cells in solid undifferentiated areas of adenoid cystic carcinomas. Our study supports the view, that modified "myoepithelial" cells in the tumours consist of a mixture of basal cells and myoepithelial cells. None of the investigated structures was in itself an ideal marker in the identification of MEC/basal cells. The cells can be identified by a combination of markers (i.e. cytokeratin 14, alpha-smooth-muscle actin, T and sialosyl-T antigens).

Therkildsen, M H; Mandel, U

1995-01-01

225

Preliminary results of radiation therapy for locally advanced or recurrent adenoid cystic carcinomas of the head and neck using combined conventional radiation therapy and hypofractionated inverse planned stereotactic radiation therapy  

International Nuclear Information System (INIS)

The purpose of this study was to investigate the clinical outcomes and feasibility of combined conventional radiation therapy (RT) and hypofractionated inverse planned stereotactic radiation therapy (SRT) for locally advanced or recurrent adenoid cystic carcinomas (ACCs) of the head and neck. Five patients with ACCs of the head and neck were treated with combined conventional RT and inverse planned SRT. Radiation doses of 40 to 50 Gy were delivered with 20 to 25 fractions using conventional RT, and then an additional 20 to 25 Gy was delivered by 4 to 5 fractions of SRT. Median follow-up was 12 months. Local control was obtained in all 5 patients, partial response (PR) in 2 patients and stable disease (SD) in 3 patients. According to the Radiation Therapy Oncology Group (RTOG) late-radiation morbidity scoring criteria, adverse effects included Grade 2 xerostomia in 1 patient, Grade 2 trismus in 1 patient, and Grade 4 mucosal ulceration in 1 patient. Combined treatment with conventional RT and hypofractionated inverse planned SRT may be effective for short-term local control in patients with locally advanced or recurrent ACCs. Further evaluation is needed for long-term follow-up. (author)

226

/ Un cas atypique d’angiomatose kystique / An atypical case of cystic angiomatosis  

Scientific Electronic Library Online (English)

Full Text Available SciELO Cuba | Language: Spanish Abstract in spanish [...] Abstract in english The paper presents a patient with bone cystic angiomatosis that is an infrequent benign tumor of vascular origin atypically located in the radius and the ulna. The clinical picture and the applied treatment are set forth. [...

2003-12-01

227

Optimization of radiation therapy for locally advanced adenoid cystic carcinomas with infiltration of the skull base using photon intensity-modulated radiation therapy (IMRT) and a carbon ion boost  

International Nuclear Information System (INIS)

Background: Tumor doses > 70 Gy are needed for local control in adenoid cystic carcinomas. These tumor doses cannot be delivered if the tolerance doses to neighboring organs at risk (OAR) are respected. This treatment planning study investigates the physical advantage of combined photon intensity-modulated radiation therapy (IMRT) plus carbon ion boost compared to photon IMRT alone. Patients and Methods: For nine patients, treatment plans were generated using a) photon IMRT alone (integrated boost concept), and b) sum plans consisting of a photon IMRT plan and a carbon ion boost plan. 54 Gy were prescribed to the planning target volume 1 (PTV1), the boost volume (PTV2) received 72 Gy. The tolerance doses of the delineated OAR were strictly adhered to. Plan quality of IMRT plans and sum plans was compared using adequate physical parameters. Results: Both therapy techniques lead to highly conformal dose distributions that allow the prescription of the desired target doses. Target conformality and heterogeneity as well as target coverage for PTV1 are comparable for both techniques. The target coverage for PTV2 can be significantly improved using carbon ion beams (median 95% coverage 93.7% vs 87%; p = 0.039). Furthermore, the mean doses to the OAR can be reduced by 8.3% (median % reduction of mean doses to OAR; p = 0.00001) using carbon ions. Conclusions: The combination of photon IMRT with carbon ions improves the target coverage for the boost volume and offers better sp for the boost volume and offers better sparing of OAR close to the PTV2 (gross tumor volume) in comparison with photon IMRT alone. A clinical study has been initiated to evaluate whether these potential advantages translate into clinical benefit. (orig.)

228

Breast- and Salivary Gland-Derived Adenoid Cystic Carcinomas: Potential Post-Transcriptional Divergencies. A Pilot Study Based on miRNA Expression Profiling of Four Cases and Review of the Potential Relevance of the Findings.  

Science.gov (United States)

Adenoid cystic carcinoma (ACC) is a malignant tumor of the salivary glands but identical tumors can also arise from the breast. Despite their similar histomorphological appearance the salivary gland- and the breast-derived forms differ in their clinical features: while ACC of the salivary glands (sACC) have an agressive clinical course, the breast-derived form (bACC) shows a very favourable clinical outcome. To date no exact molecular alterations have yet been identified which would explain the diverse clinical features of the ACCs of different origin. In our pilot experiment we investigated the post-transcriptional features of ACC cases by performing microRNA-profiling on 2-2 bACC and sACC tissues and on 1-1 normal breast and salivary gland tissue. By comparing the microRNA-profiles of the investigated samples we identified microRNAs which were expressed differently in bACC and sACC cases according to their normal controls: 7 microRNAs were overexpressed in sACC cases and downexpressed in bACC tumors (let-7b, let-7c, miR-17, miR-20a, miR-24, miR-195, miR-768-3) while 9 microRNAs were downexpressed in sACC cases and overexpressed in bACC tissues (let-7e, miR-23b, miR-27b, miR-193b, miR-320a, miR-320c, miR-768-5p, miR-1280 and miR-1826) relative to their controls. We also identified 8 microRNAs which were only expressed in sACCs and one microRNA (miR-1234) which was only absent in sACC cases. By target predictor online databases potential targets of the these microRNAs were detected to identify genes that may play central role in the diverse cinical outcome of bACC and sACC cases. PMID:25240490

Kiss, Orsolya; T?kés, Anna-Mária; Spisák, Sándor; Szilágyi, Anna; Lippai, Norbert; Székely, Borbála; Szász, A Marcell; Kulka, Janina

2015-01-01

229

Análise quantitativa das AgNORs no carcinoma adenóide cístico intra-oral através da técnica de dupla marcação PCNA/AgNOR / PCNA/AgNOR double staining technique in adenoid cystic carcinoma  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese A análise quantitativa das AgNORs e a imunomarcação para o PCNA têm sido empregadas de forma independente na avaliação da proliferação celular de vários tumores, e, em muitos casos, têm mostrado correlação positiva. Entretanto poucos trabalhos têm avaliado, em um mesmo corte histológico, a relação e [...] ntre PCNA e AgNOR. O objetivo deste trabalho foi otimizar a técnica de dupla marcação com a finalidade de se estudar simultaneamente a correlação entre PCNA e AgNOR no carcinoma adenóide cístico (CAC) de glândulas salivares menores. Foram selecionados 16 casos de CAC classificados de acordo com o subtipo histológico. A análise quantitativa das AgNORs foi feita por meio de análise de imagens. As AgNORs foram contadas em cem núcleos PCNA positivos e em cem núcleos PCNA negativos. O número médio de AgNOR nos núcleos PCNA positivos foi 2,14 ± 0,77, e, nos núcleos PCNA negativos, 1,97 ± 0,79, entretanto esta diferença não se mostrou estatisticamente significante (p = 0,2537). Nosso trabalho não mostrou correlação entre o número de AgNOR e a imunomarcação para o PCNA em CAC quando estes marcadores foram demonstrados simultaneamente através da dupla marcação. Quanto à técnica, o uso do microondas melhorou a coloração da AgNOR, permitindo uma redução no tempo de incubação com a solução de prata e uma melhor individualização das AgNORs, o que facilitou os procedimentos de contagem. Abstract in english No previous studies have simultaneously assessed the relationship between AgNORs and PCNA expression in salivary gland tumors. We describe a method to demonstrate both PCNA and AgNORs in the same slice of routinely processed tissue. We also evaluated the effect of microwaving on the AgNORs reaction. [...] Sixteen cases of adenoid cystic carcinoma (ACC) were selected and the double staining technique was performed in order to quantify the number of AgNORs in PCNA-positive and negative cells. The best results were obtained when AgNOR was performed after the immunostaining. The microwave oven heating improved the AgNORs staining. Our results did not show a statistical difference between the mean number of AgNORs in PCNA-negative and positive cells. There is no association between PCNA and AGNOR in ACC when they are assessed by double-staining.

Elena Riet-Correa, Rivero; Maria Cássia Ferreira de, Aguiar.

2002-01-01

230

Adenoid ameloblastoma with dentinoid: a case report.  

Science.gov (United States)

A man had a lesion of the anterior mandible that was initially diagnosed at 39 years of age as an adenomatoid odontogenic tumor. The lesion recurred 3 times over a span of 16 years. A consultative review of all histological findings was done and the tumor was reclassified as an ameloblastoma. PMID:15529131

Evans, Brian L; Carr, Ronald F; Phillipe, Lynn J

2004-11-01

231

Bacteremia during adenoidectomy: a comparison of suction diathermy adenoid ablation and adenoid curettage.  

LENUS (Irish Health Repository)

Transient bacteremia is induced by adenoidectomy when the integrity of the nasopharyngeal membrane is broken. The aim of this study was to determine the incidence of bacteremia in patients undergoing adenoidectomy, to identify the causative organisms, and to compare the incidences of bacteremia between the two techniques suction diathermy and curettage.

Casserly, Paula

2010-08-01

232

Un faux kyste pancréatique mimant une tumeur kystique et doublement compliqué de compression digestive et d'hémorragie: la pancréatite aiguë, la saga continue  

Science.gov (United States)

L'histoire naturelle des pancréatites aigues nécrotico-hémorragiques est parfois caractérisée par la survenue imprévisible de plusieurs complications. La formation de pseudos kystes constitue un tournant évolutif important lors de sa survenue. Son évolution est imprévisible pouvant aller de la simple résorption spontanée à la survenue de complications gravissimes. Les principales complications observées sont l'obstruction, la surinfection et l'hémorragie. Nous rapportons le cas d'une pancréatite aigue lithiasique compliquée d'un faux kyste de pancréas compressif et d'un faux anévrysme artériel. L'intérêt de cet observation réside d'une part dans l'originalité de la présentation clinique, du fait que l'histoire naturelle de cette affection n'est pas toujours connue, ce qui pose parfois des difficultés diagnostic et justifie une discussion pluridisciplinaire, et d'autre part dans la rareté des cas publiés avec, à la fois, des complications hémorragique,et compressive: digestive et canalaires biliaires. PMID:25422696

Ameuraoui, Taoufiq; Alami, Baderedine; Boubbou, Meryem; Maaroufi, Mustapha; Kamaoui, Imane; Tizniti, Siham

2014-01-01

233

Organ Preservation for Adenoid Cystic Carcinoma of the Larynx  

OpenAIRE

Two cases of ACC of the larynx were treated with CRT for organ preservation. The patients completed a course of combined chemoradiotherapy with weekly carboplatin and paclitaxel and radiotherapy. Both patients are alive with local regional control and functional larynx, therefore, chemoradiation with weekly carboplatin and paclitaxel may be a potential alternative to the current treatment.

Misiukiewicz, Krzysztof J.; Camille, Nadia; Tishler, Roy; Haddad, Robert; Limaye, Sewanti; Posner, Marshall

2013-01-01

234

Non-surgical management of hepatocellular carcinoma; Prise en charge non chirurgicale du carcinome hepatocellulaire  

Energy Technology Data Exchange (ETDEWEB)

Most of patients with hepatocellular carcinoma (HCC) cannot benefit from surgical therapies. Among non-surgical options, only radiofrequency can challenge surgery for small size tumours. Conformal radiotherapy is likely highly efficient on solitary tumours, but controlled studies are warranted to conclude. Other options are purely palliative. Trans-arterial hepatic chemo-embolization is the goal-standard for multifocal hepatocellular carcinoma and Sorafenib for hepatocellular carcinoma with portal vein invasion, leading to modest but significant benefit on survival rates. Yttrium-90 radio-embolization is under evaluation through controlled studies, and could be of major interest for multifocal hepatocellular carcinoma with or without portal venous invasion. (authors)

Merle, P. [Service d' hepato-gastroenterologie, hopital de l' Hotel-Dieu, 69 - Lyon (France); Inserm U871 -Oncogenese hepatique et hepatites virales-, 69 - Lyon (France); IFR62 Lyon-Est, universite Lyon 1, 69 - Lyon (France); Mornex, F. [Departement de radiotherapie-oncologie, centre hospitalier Lyon-Sud, 69 - Pierre-Benite (France)

2010-10-15

235

Small bowel obstruction caused by peritoneal immunoglobulin G4-related disease mimicking carcinomators: Case report  

Energy Technology Data Exchange (ETDEWEB)

We hereby report a case of diffuse pelvic peritoneal involvement by immunoglobulin G4-related disease (IgG4-RD). Numerous pelvic masses and nodules showing delayed enhancement on enhanced abdominal CT were found to congregate in the pelvic organs of a 57-year-old female presenting with intestinal subocclusion. The differentiation between peritoneal IgG4-RD and pelvic peritoneal carcinomatosis was only made by histopathology and immunohistochemistry performed after surgical resection. Autoimmune pancreatitis represents the historical prototype of IgG4-RD, but the spectrum of manifestations involving various organs has expanded during the last decade. In this report, we shortly review this clinical entity.

Coulier, Bruno; Montfort, Luc; Pierard, Frederic [Clinique St. Luc, Bouge (Belgium); Beniuga, Gabrique; Gielen, Lsabelle [Institute of Pathology and Genetics, Gosselies (Belgium)

2014-02-15

236

Late neurotoxicity after nasopharyngeal carcinoma treatment;Toxicite neurologique tardive apres traitement des carcinomes nasopharynges  

Energy Technology Data Exchange (ETDEWEB)

Purpose A retrospective analysis of risk factors for late neurological toxicity after nasopharyngeal carcinoma radiotherapy. Patients and methods Between 1993 and 2004, 239 patients with non metastatic nasopharyngeal carcinoma were treated by radiotherapy associated or not to chemotherapy. Radiotherapy was delivered with two modalities: hyperfractionated for 82 patients and conventional fractionation for 157 patients. We evaluated the impact of tumour stage, age, gender, radiotherapy schedule and chemotherapy on neurological toxicity. Results After a mean follow-up of 107 months (35-176 months), 21 patients (8.8%) developed neurological complications, such as temporal necrosis in nine cases, brain stem necrosis in five cases, optics nerve atrophy in two cases and myelitis in one case. Five- and ten-year free of toxicity survival was 95 and 84% respectively. Young patients had greater risk of temporal necrosis, and hyperfractionated radiotherapy was associated with a significantly higher risk of neurological complications (14.6% vs 5.7%, p = 0.02). On multivariate analysis, hyperfractionation and age were insignificant. Conclusion Late neurological toxicity after radiotherapy for nasopharyngeal carcinoma was rare. Younger age and hyperfractionation were considered as risk factors of neurological toxicity in our study

Siala, W.; Mnejja, W.; Daoud, J. [Hopital Habib-Bourguiba, Service de Radiotherapie Carcinologique, Sfax (Tunisia); Khabir, A.; Boudawara, T. [Hopital Habib-Bourguiba, Service d' Anatomopathologie, Sfax (Tunisia); Ben Mahfoudh, K. [Hopital Habib-Bourguiba, Service de Radiologie, Sfax (Tunisia); Ghorbel, A. [Hopital Habib-Bourguiba, Service d' ORL, Sfax (Tunisia); Frikha, M. [Hopital Habib-Bourguiba, Service de Carcinologie Medicale, Sfax (Tunisia)

2009-12-15

237

Well-differentiated thyroid carcinoma in Martinique; Carcinome thyroidien differencie en Martinique  

Energy Technology Data Exchange (ETDEWEB)

The thyroid neoplasm is easily entered in the accounts in Martinique with the Tumor Registry created in 1981. This is not a frequent cancer but its frequency grew since 1981 till 1995. The treatment of the well differentiated thyroid cancer is well standardized with a total thyroidectomy generally followed by a metabolic thyroidectomy with {sup 131}I. The follow-up is composed by clinical exam, TSH and thyroglobulin measurements. The results are very good and we mean to continue this strategy refining it for the little papillary tumors and using the recombinant TSH. The Tchernobyl event in 1986 generated new epidemiological considerations and has been the object of multiples studies.The studies realized in such a very distant site like Martinique permitted the realization of comparisons with the Tumor Registry of the 'Bas Rhin' in France a geographical area that could have been concerned by the disaster. The result of this study fends a growth of the incidence of the thyroid neoplasm almost identical with that registered in the mainland with a net increase for the papillary neoplasms. We may then conclude that the growth percentage since 1981 till 1995 due to the availability and more frequent using of many new diagnostic means less operator-dependent than before. By this descriptive study we may purport that the incidence of the thyroid cancer is low (4,45 per 100000 population for women and 0,9 per 100000 population for men). Treatment is consensual and thanks to the lifelong administration of exogenous thyroid hormone the quality of life of these patients is maintained along with a sure recovery in most of the cases. The mortality due to the thyroid cancer is very low in the orthoplasic form (less than 1 % of all types of cancer). The precocious screening of the thyroid neoplasm has to enter then in the guidelines in medical education. It consists in the systematical exploring of a thyroid nodule by clinical exam and by ultrasonography, radioisotope scanning with Tc-99m pertechnetate and by fine-needle aspiration if a well-trained thyroid cyto-pathologist is available. The aim is to find a compromise between an easy-to-live follow up and the inopportune removal of the thyroid nodules. (authors)

Azaloux, H.; Dieye, M.; Draganescu, C.; Istrate, M.; Dorival, M.J.; Baudin-Veronique, J.; Escarmant, P.; Amar, A.; Francois, H. [Centre Hospitalier Universitaire de Fort-de-France, Medecine Nucleaire, Hopital Pierre Zobda-Quitman, 97 - Fort-de-France (France)

2002-12-01

238

Nasopharyngeal carcinomas: from biology to clinic; Les carcinomes du nasopharynx: de la biologie a la clinique  

Energy Technology Data Exchange (ETDEWEB)

Nasopharyngeal carcinomas (NPC) are very different from other head and neck cancers because of their specific multi-factorial etiology and their geographic distribution. Epstein-Barr Virus (EBV) is implicated in onco-genesis of NPC in association with genetic alterations such as inactivation of the p16/Ink4, p19/ARF, RASSFI or Blu genes. Tumoral tissues include a very abundant characteristic lymphoid infiltrate. Inflammatory cytokines are produced by both malignant and infiltrating cells. There is no efficient immune response against the tumor. On the opposite, infiltrating lymphocytes might play a role in tumor development. Serological methods and detection of circulating viral DNA are expected to become useful for early detection of relapse and on a longer term for primary screening. NPC are often diagnosed at a late stage because patients may remain asymptomatic for a long time. Computed tomography (CT scan) and magnetic resonance imaging (MRI) are complementary for the initial evaluation. Positron emission tomography (PET) is efficient for the evaluation of treatment efficiency and detection of relapses. Treatment is based on radiotherapy and chemotherapy. Their optimal use needs to be evaluated by phase III trials but positive results have been obtained by concomitant association of radiotherapy and chemotherapy. Targeted therapies are being studied with strategies based on disruption of viral latency, use of replicative adeno-viruses or anti-tumor vaccination. (author)

Rivera, S.; Maingon, P. [Centre Georges-Francois-Leclerc, Dept. de Radiotherapie, 21 - Dijon (France); Keryer, C.; Busson, P. [Institut Gustave-Roussy, CNRS/UMR 8126, 94 - Villejuif (France)

2005-02-15

239

Skeleton scintigraphy and radiologic data at 403 patients with prostata carcinom  

International Nuclear Information System (INIS)

In a retrospective study 403 patients with prostatic carcinoma (PC) were examined to shed light on the relation between the rate of metastases and the stage of local tumor spread as well as the histomorphologic tumor type; to establish the rate of metastases detected by bone scanning versus radiology; and to compare the contributions of bone scanning versus radiology in monitoring the response of bone metastases to treatment. Results: (1) The rate of metastases was found to increase as a function of primary tumor size and increasing dedifferentiation; however, bone metastases were also seen in highly differentiated stage O and A PC. (2) Solitary metastases were confined to the pelvic bones and lumbar vertebrae. (3) About one third of all bone metastases were radiologically silent; in sporadic cases receiving contrasexual therapy they remained silent for more than 5 years. (4) Bone scnaning showed 73.3% of patients to respond to contrasexual therapy and 26.7% to be non- responders. (6) There were some differences or even discrepancies between bone scans and radiology in documenting the results of treatment. Conclusions: Repeated bone scans are required for monitoring the course of the disease even if the primary tumor is extremely small and histologically well differentiated. Bone scans are superior to radiology in detecting metastases. While repeat X-rays during the course of a disease furnish important information, they are unsuited for monitoring the response to trensuited for monitoring the response to treatment. (Author)

240

Sorafenib and radiotherapy association for hepatocellular carcinoma; Sorafenib et radiotherapie dans le carcinome hepatocellulaire  

Energy Technology Data Exchange (ETDEWEB)

Conformal radiotherapy is a promising therapeutic strategy for hepatocellular carcinoma (HCC), producing local control rates above 90% within the radiation beam. However, survival after radiotherapy remains limited by the high frequency of intra- and extra-hepatic recurrences, which occurs in 40-50 and 20-30% of cases, respectively. Sorafenib (BAY43-9006, Nexavar; Bayer, West Haven, CT) is a small molecule inhibitor that demonstrated potent activity to target v-raf murine sarcoma oncogene homologue B1 (BRAF) and VEGFR tyrosine kinases. Sorafenib is the only drug that demonstrated effectiveness to increase overall survival in advanced or metastatic hepatocellular carcinoma. The rationale to combine radiotherapy with sorafenib is the following: (1) targeting RAS-RAF-MAPK and VEGFR signaling pathways, which are specifically activated after exposure to radiation, and responsible for radio-resistance phenomenon; (2) enhancing the oxygen effect through normalization of the surviving tumor vasculature; and (3) synchronization of the cell cycle. Sorafenib and radiotherapy represent complementary strategies, as radiotherapy may be useful to prolong the effect of sorafenib through control of the macroscopic disease, when sorafenib may target latent microscopic disease. Sorafenib and radiotherapy associations are thus based on a relevant biological and clinical rationale and are being evaluated in ongoing phase I-II trials. (authors)

Girard, N. [Service de pneumologie, hopital Louis-Pradel, hospices Civils de Lyon, 28, avenue du Doyen-Jean-Lepine, 69500 Bron (France); UMR 754, universite Claude-Bernard Lyon 1, 43, boulevard du 11-novembre-1918, 69622 Villeurbanne cedex (France); Mornex, F. [UMR 754, universite Claude-Bernard Lyon 1, 43, boulevard du 11-novembre-1918, 69622 Villeurbanne cedex (France); Departement de radiotherapie-oncologie, centre hospitalier Lyon Sud, 165, chemin du Grand-Revoyet, 69495 Pierre-Benite cedex (France)

2011-02-15

241

Therapy of metastasized differentiated thyroid carcinoms; Therapie des metastasierten differenzierten Schilddruesenkarzinoms  

Energy Technology Data Exchange (ETDEWEB)

Therapy with radioiodine is the only curative option in differentiated metastasized thyroid carcinoma (subsequent to surgical intervention). Therapy in case of metatases is of particular relevance in patients with thyroid carcinoma of stage pT4, i.e. in case of expansive growth, as this stage is characterized by frequent hematogenous dissemination of tumor cells. As to histology there are prognostic differences: Follicular thyroid carcinomas are more frequently associated with osseous metastases than papillary carcinomas, and osseous metastases can only be successfully treated in a relatively small percentage. In cases of initial osseous metastases, however, the results of radioiodine therapy are more promising. Compared with delayed development of osseous metastases, initial metastases show significantly radioiodine uptake on average. To date, it has been clarified that there are good chances to cure patients with initial bone metastases by consequent high-dose radioiodine therapy, contrary to wide-spread opinion. Apart from radioiodine uptake, tumor stage, histology, and location of metastases, the patient's age at manifestation of disease is a further prognostic factor when treating metastases of the differentiated thyroid carcinoma. The potential of therapy is limited by hematoxicity when the dose administered exceeds 50-100 GBq. Alternative modalities of therapy like external radiation or chemotherapy by itself or combined with radiation are not sufficiently effective until now. Recently developed therapeutic concepts are still in an experimental stage. After a period of stagnation in methodological development of radioiodine therapy, modifications of treatment modalities (e.g., by combining external radiation with chemotherapy, by applying retinoids or rhTSH etc.) are being evaluated. (orig./MG) [German] Die Radiojodtherapie (RJT) ist derzeit die einzige Behandlungsform mit kurativem Ansatz beim differenzierten metastasierten SD-Karzinom (nach vorangegangener chirurgischer Intervention). Diese therapeutische Option kommt vor allem Patienten mit organueberschreitendem Wachstum des Primaertumors zugute, da im pT4-Stadium eine haematogene Metastasierung besonders haeufig ist. Hinsichtlich der Histologie bestehen prognostische Unterschiede insofern, als follikulaere SD-Karzinome haeufiger ossaer metastasieren als papillaere Karzinome, und ossaere Metastasen durch RJT seltener kurativ behandelt werden koennen. Guenstiger sind die Ergebnisse der RJT bei der Behandlung initialer ossaerer Metastasen, die im Vergleich zu spaeter auftretenden ossaeren Metastasen eine signifikant hoehere RJ-Aufnahme und -Speicherung aufweisen. Es ist inzwischen eindeutig belegt, dass durch eine konsequente hochdosierte RJT insbesondere bei Patienten mit initialen Knochenmetastasen (entgegen weitverbreiteter Meinung) gute Heilungschancen bestehen. Neben der RJ-Speicherung, dem Tumorstadium, der Histologie und der Lokalisation der Metastasen ist das Alter des Patienten bei Erstdiagnose ein weiterer prognostischer Faktor bei der Behandlung von Metastasen des differenzierten SD-Karzinoms. Limitiert wird die RJT durch die Haematotoxizitaet, die vor allem ab einer Aktivitaet von 50-100 GBq besonders zum Ausdruck kommt. Andere Therapieformen, wie z.B. Radiatio, Chemotherapie allein oder als Kombinationsbehandlung, sind bislang nicht zufriedenstellend wirksam. Neuere Behandlungskonzepte sind noch im experimentellen Stadium. Nach einer laengeren Phase des methodischen Entwicklungsstillstandes der RJT zeichnen sich nun Veraenderungen der Behandlungsmodalitaeten (z.B. durch Kombination mit externer Radiatio und Chemotherapie, durch Einsatz von Retinioden und rhTSH etc.) ab, die zu einer weiteren Verbesserung der Ergebnisse fuehren bzw. das Spektrum der behandelbaren Patienten erweitern koennten. (orig./MG)

Petrich, T.; Knapp, W.H. [Medizinische Hochschule Hannover (Germany). Klinik fuer Nuklearmedizin

2000-03-01

242

Traitement des carcinomes du larynx par radiothérapie radicales avec ou sans chimiothérapie: résultats et facteurs pronostiques  

OpenAIRE

Le but de cette étude est d'examiner l'impact de l'envahissement des différents sous-sites du larynx sur les résultats oncologiques lors du traitement de cancers laryngés avec la radiothérapie ± chimiothérapie. Pour cela, une étude rétrospective de patients consécutifs traités aux HUG entre 1996-2005 par cette modalité a été entreprise. Nos résultats montrent que les stades T avancés, une atteinte de la commissure antérieure et de la sous-glotte sont associés à une survie e...

Shehata, Emad

2009-01-01

243

Carcinomes à cellules rénales et facteurs pronostiques. [Renal cell carcinoma and prognostic factors  

OpenAIRE

Histological and prognostic patterns of renal cell carcinoma vary greatly, sometimes hindering accurate prognosis. Classical histological prognostic factors have emerged during the last 25 years, the two predominant factors being TNM stage and nuclear Fuhrman grade. However, the use of new treatment strategies, targeting tumoral angiogenesis, make it necessary to develop new prognostic markers. Microvascular density, plasmatic and tissue expression of VEGF, such as intratumoral expression of ...

Edeline, Julien; Rioux-leclercq, Nathalie

2008-01-01

244

Le carcinome rectal: nécessité de la radiothérapie dans l'élaboration du plan thérapeutique.  

OpenAIRE

Postoperative radiotherapy is highly effective in the prevention of local recurrence in rectal cancer. Nevertheless, the results remain disappointing for Locally Advanced Rectal Cancer. New approaches include introduction of chemotherapy to postoperative radiotherapy or combined radiotherapeutic treatment with preoperative irradiation, surgery and intraoperative irradiation, along with elective postoperative treatment in function of surgical and pathological data. Based on recent advances in ...

Coucke, Philippe; Bosset, J-f; Mirimanoff, R-o

1991-01-01

245

Analysis of the economic impact of cystic echinococcosis in Spain / Analyse de l'impact économique de l'échinococcose kystique en Espagne / Análisis del impacto económico de la hidatidosis en España  

Scientific Electronic Library Online (English)

Full Text Available SciELO Public Health | Language: English Abstract in spanish OBJETIVO: Estimar las pérdidas económicas totales ocasionadas por la hidatidosis humana y animal en España en 2005. MÉTODOS: Los datos sobre la incidencia anual de la hidatidosis se obtuvieron a partir de los registros de vigilancia epidemiológica y de los mataderos. Los datos sobre el tratamiento y [...] la pérdida de productividad (humana y animal) relacionada con la enfermedad se obtuvieron a partir de la literatura científica. Los costes directos fueron los asociados al diagnóstico, el tratamiento quirúrgico o farmacológico, la atención médica y la hospitalización en humanos, y los decomisos de vísceras infectadas en animales de abasto (ganado ovino, caprino, bovino y porcino). Los costes indirectos comprendieron la pérdida de productividad en humanos y la reducción de las tasas de crecimiento, fecundidad y producción de leche en el ganado. Para representar la incertidumbre asociada a los parámetros analizados se utilizó el método del hipercubo latino. RESULTADOS: Las pérdidas económicas totales atribuibles a la hidatidosis humana y animal fueron estimadas en 148 964 534 euros (€) (intervalo de credibilidad del 95%, IC95%: 21 980 446-394 012 706). Las pérdidas estimadas de origen humano fueron de € 133 416 601 (IC95%: 6 658 738-379 273 434), y de € 15 532 242 (IC95%: 13 447 378-17 789 491) las de origen animal. CONCLUSIÓN: La hidatidosis es una zoonosis desatendida que en España sigue constituyendo un problema de salud humana y animal. Son necesarios datos más exactos sobre la prevalencia de la hidatidosis en humanos (sobre todo en los casos no diagnosticados o asintomáticos) y mejores métodos para calcular la pérdida de productividad en animales. La hidatidosis sigue afectando a ciertas zonas de España pese a las varias campañas de control emprendidas desde 1986. Dada la gran carga económica de la hidatidosis, es necesaria una mayor financiación para reducir las tasas de infección humana y animal mediante mejoras en la vigilancia de la enfermedad, el tratamiento periódico de los perros y la cooperación entre organismos oficiales. Abstract in english OBJECTIVE: To estimate the overall economic losses due to human and animal cystic echinococcosis (CE) in Spain in 2005. METHODS: We obtained data on annual CE incidence from surveillance and abattoir records, and on CE-related treatment and productivity losses (human and animal) from the scientific [...] literature. Direct costs were those associated with diagnosis, surgical or chemotherapeutic treatment, medical care and hospitalization in humans, and condemnation of offal in livestock (sheep, goats, cattle and pigs). Indirect costs comprised human productivity losses and the reduction in growth, fecundity and milk production in livestock. The Latin hypercube method was used to represent the uncertainty surrounding the input parameters. FINDINGS: The overall economic loss attributable to CE in humans and animals in 2005 was estimated at 148 964 534 euros (€) (95% credible interval, CI: 21 980 446-394 012 706). Human-associated losses were estimated at €133 416 601 (95% CI: 6 658 738-379 273 434) and animal-associated losses at €15 532 242 (95% CI: 13 447 378-17 789 491). CONCLUSION: CE is a neglected zoonosis that remains a human and animal health concern for Spain. More accurate data on CE prevalence in humans (particularly undiagnosed or asymptomatic cases) and better methods to estimate productivity losses in animals are needed. CE continues to affect certain areas of Spain, despite several control initiatives since 1986. Given the high economic burden of CE, additional funding is needed to reduce human and animal infection rates through improved disease surveillance, regular treatment of dogs and greater cooperation between agencies.

Christine, Benner; Hélène, Carabin; Luisa P, Sánchez-Serrano; Christine M, Budke; David, Carmena.

2010-01-01

246

Reirradiation by Cyberknife of head and neck carcinomas; Reirradiation par Cyberknife de carcinomes de la tete et du cou  

Energy Technology Data Exchange (ETDEWEB)

In spite of local treatment the local defeat is a problem in O.R.L. cancerology. It has been demonstrated that some recurrences or second cancers in beforehand irradiated area could be sterilized by a new irradiation of high dose after perfect definition of the volume to treat and the certainty that recurrence will be localized.Numerous works have allowed to underline that a part of patients, with an O.R.L. recurrence can be treated again with curative aim with survival rate about 20 to 20 % at three years. The objective of this study was to test with a phase two study, the validation of a stereotaxic type reirradiation by Cyberknife associated to Cetuximab. (N.C.)

Balajouza Kanoun, S.; Lacornirie, T.; Coche Dequeant, B.; Mirabel, X.; Lefebvre, J.L.; Lartigau, E. [Centre Oscar-Lambret, Univ. de Lille-2, Dept. Universitaire de Radiotherapie, 59 - Lille (France)

2007-11-15

247

Adjuvant radiotherapy of biliary vesicle and duct cancers; Radiotherapie adjuvante des carcinomes de la vesicule et des voies biliaires  

Energy Technology Data Exchange (ETDEWEB)

Between 1993 and 2007, eight patients have been treated by postoperative adjuvant irradiation for biliary vesicle and extra-hepatic biliary duct cancer. The authors recall how these cancers were discovered, operated, and what revealed the postoperative analysis. Although the prognostic is rather unfavourable, the postoperative concomitant chemo-radiotherapy resulted in a local control and in a ten year survival in 25% of cases. Short communication

Salah, H.B.; Kallel, M.; Beyrouti, I.; Frikha, M.; Daoud, J. [CHU Habib-Bourguiba, Sfax (Tunisia)

2010-10-15

248

Prophylactic cranial irradiation in small-cell lung cancer; Irradiation prophylactique cerebrale dans les carcinomes bronchiques a petites cellules  

Energy Technology Data Exchange (ETDEWEB)

In small-cell lung cancer, there is a high risk of cranial relapse, which may reach nearly 50% at 2 years in patients in complete remission following appropriate induction treatment. Several randomized studies have shown that prophylactic cranial irradiation reduces the risk of tumour dissemination by 2- to 3-fold. However, prophylactic cranial irradiation remains a controversial issue due to its potential neurotoxicity, which has been reported in a number of small-scale retrospective studies, and also because of the absence of a significant effect on overall survival observed in the various randomized trials, which were not carried out on a sufficientlylarge scale. In contradiction with these findings, a recently published meta-analysis evaluating the role of prophylactic cranial irradiation in complete responders not only confirmed its positive effect on the incidence of brain metastases at 3 years, but also showed an absolute increase in overall survival of 5%. It is concluded that prophylactic cranial irradiation should therefore be considered as part of the standard treatment in small-cell lung cancer complete responders. However, several questions still remain unanswered, such as the optimal radiation dose to be prescribed, the optimal time interval between induction treatment and cranial irradiation, and the long-term evaluation of possible late sequelae. These issues should be examined in further prospective studies. (author)

Bardet, E. [Centre Regional de Lutte contre le cancer Nantes-Atlantique Rene-Gauducheau, 44 - Saint-Herblain (France); Le Pechoux, C. [Institut Gustave Roussy, 94 - Villejuif (France)

1999-11-01

249

The evolving role of radiation therapy in hepatocellular carcinoma; Place de la radiotherapie dans le carcinome hepatocellulaire  

Energy Technology Data Exchange (ETDEWEB)

Technical advancements in imaging, in radiation therapy (R.T.) planning and R.T. delivery, have facilitated the safe delivery of conformal radiation therapy to patients with unresectable hepatocellular carcinoma (H.C.C.). Although experience in liver cancer R.T. is limited, the R.T. technologies and tools to deliver R.T. safely are being disseminated rapidly. A variety of doses and R.T. fractionations have been used to treat H.C.C., and R.T. has been used in combination with other therapies including trans arterial hepatic chemo embolization (T.A.C.E.). Outcomes following R.T. alone or R.T. and T.A.C.E. appear better than outcomes following similar historical controls of T.A.C.E. alone, however, randomized trials of R.T. are needed. The first site of recurrence following R.T. is most often within the liver, away from the high dose volume, providing rationale for combining R.T. with regional or systemic therapies. Given the vascular properties of H.C.C., the combination of R.T. with anti-V.E.G.F. targeted agents may improve outcomes further. (author)

Dawson, L.A. [Toronto Univ., Dept. of Radiation Oncology, Princess Margaret Hospital, Ontario (Canada)

2008-03-15

250

Influence du stroma et des cellules souches mésenchymateuses sur la dissémination et la résistance au traitement des carcinomes ovariens épithéliaux  

OpenAIRE

Le cancer épithélial de l'ovaire (EOC) a la particularité d'être diagnostiqué à un stade avancé chez 75% des patientes et de récidiver dans un grand nombre de cas malgré une bonne réponse initiale à la chimiothérapie, expliquant ainsi son pronostic sombre. Le rôle du microenvironnement tumoral semble être de premier plan dans le développement et la survie des cellules cancéreuses mais il existe encore peu de données concernant les cellules mésenchymateuses souches (MSC). Dan...

Touboul, Cyril

2012-01-01

251

Is the adaptive tomography of cervical carcinomas necessary?; La tomotherapie adaptative des carcinomes du col uterin est-elle necessaire?  

Energy Technology Data Exchange (ETDEWEB)

The authors report the study of the macroscopic tumour volume (GTV, gross tumour volume) and its possible repercussion on organs at risk during a tomo-therapy with an additional concomitant centro-pelvic irradiation. Ten women with non-operable cervical carcinomas have been treated by tomo-therapy and chemotherapy. A high-energy conical tomography has been performed before each session. Data obtained from these tomographies have been used in the adaptive therapy module of a tomo-therapy planimetry software. It appears that there is no evidence of significant variations of doses at the level of organs at risk with the use of such software. Short communication

Le Tinier, F.; Nickers, P.; Reynaert, N.; Castelain, B.; Lacornerie, T.; Attar, M.; Lartigau, E. [Centre Oscar-Lambret, 59 - Lille (France)

2010-10-15

252

Radio-embolization for hepatocellular carcinoma; Traitement des carcinomes hepatocellulaires par injection intra-arterielle de radio-isotopes  

Energy Technology Data Exchange (ETDEWEB)

Hepatocellular carcinoma is now a major public health concern. In intermediate stages (one third of hepatocellular carcinoma patients), chemo-embolization is the standard of care despite a poor tolerance and a moderate efficacy. Moreover, despite recent improvements, this technique seems in a dead end. Radio-embolization could be an excellent tool for such patients. Currently {sup 131}I-Lipiodol, {sup 188}Re-Lipiodol, {sup 90}Y-glass or resin microspheres are available. More recent and promising data come from microspheres, but phase II and III studies are needed before drawing any conclusion. In the future, the combination of radio-embolization with systemic chemotherapy or targeted agents (particularly anti-angiogenic drugs) seems very promising. (authors)

Raoul, J.L. [Departement d' oncologie medicale, centre Eugene-Marquis, rue de la bataille Flandres-Dunkerque, CS 44229, 35042 Rennes cedex (France); Inserm U911, centre Eugene-Marquis, CS 44229, 35042 Rennes cedex (France); Edeline, J.; Pracht, M.; Boucher, E. [Departement d' oncologie medicale, centre Eugene-Marquis, rue de la bataille Flandres-Dunkerque, CS 44229, 35042 Rennes cedex (France); Rolland, Y. [Departement d' imagerie medicale, centre Eugene-Marquis, CS 44229, 35042 Rennes cedex (France); Garin, E. [Inserm U911, centre Eugene-Marquis, CS 44229, 35042 Rennes cedex (France); Departement d' imagerie medicale, centre Eugene-Marquis, CS 44229, 35042 Rennes cedex (France)

2011-02-15

253

Results of fast neutron therapy of adenoid cystic carcinoma of the salivary glands  

International Nuclear Information System (INIS)

72 consecutive patients with ACC were treated with fast neutrons, 66 after surgery, 6 for primarily unresectable disease, 43/66 for macroscopic residual disease, 23/66 for unresectable recurrent disease. 45/72 tumors were localized in the minor, 27 in the major salivary glands. T-stage was in 13 pts T2, in 33 T3, in 26 T4; positive nodes were in 10 pts. M+ in 15 pts. Mean tumor volume was 89 cm3. Neutron therapy was 15.03 Gy in 3 weeks with 1.67 Gy per fraction three times per week. Individual computer assisted treatment planning was performed based on CT and/or MRI, using bolus material if necessary. Target volume was the macroscopic tumor volume with a generous safety margin. Results: Complete response was achieved in 28 pts, partial response in 35 pts. Local control was observed in 73.4% after a mean observation period of 36 months. Overall and recurrence free survival was 85%/81% at two years, and 58%/53% at 5 years (Kaplan-Meier). In univariate analysis tumor volume (> 100 cm3), distant metastases, histologic subtype (solid) and neutron dose (<15 Gy) turned out to be significant parameters for predicting outcome, in multivariate analysis tumor volume and histologic subtype remained the only significant parameters. Acute morbidity was grade III/IV (EORTC/RTOG) in 6% for skin (desquamation), in 4% for mucosa (ulceration), late morbidity (grade III/IV) in one patient with local temporal brain necrosis. (orig.)(orig.)

254

Paclitaxel, carboplatin followed by a concomitant chemoradiotherapy in the undifferentiated cavum cancers; Paclitaxel, carboplatine suivi d'une chimioradiotherapie concomitante dans les carcinomes indifferencies du cavum  

Energy Technology Data Exchange (ETDEWEB)

Purpose: for more than two decades, the association of cisplatin and 5-fluoro-uracil stayed the standard treatment for epidermoid carcinomas of aero digestive system. Recently, the taxanes showed their efficiency in this pathology during studies of phase 2 and it is expected from the paclitaxel and carboplatin association followed by a concomitant radio chemotherapy a better rate of local control of the metastatic disease and complete remission for a long time. Conclusion: the use of the protocol of chemotherapy followed by a concomitant chemoradiotherapy can be a standard of therapy for the locally evolved injuries. It gives a high objective response rate and local control and a global survival rate at five years at 58%. (N.C.)

Djekkoun, R.; Ferdi, N.; Boudaoud, K. [CAC CHU, Constantine (Algeria); Bouzid, K. [CPMC, Alger (Algeria)

2009-10-15

255

Amputación interescapulotorácica por cromomicosis y carcinoma epidermoide / Amputation interscapulothracique pourchr4omomycose et6 carcinome épidermoide / Interscapulothoracic amputation by chromomycosis and epidermoid carcinoma  

Scientific Electronic Library Online (English)

Full Text Available SciELO Cuba | Language: Spanish Abstract in spanish Paciente del sexo masculino y blanco de 74 años de edad, con lesión dermatológica hiperpigmentada y verrucosa de más de 25 años de evolución en codo y antebrazo izquierdo; asimismo posee otra de piel en forma de coliflor y cuya evolución es reciente. Ambas presentaron diagnóstico histopatológico de [...] cromomicosis. El tratamiento inicial fue la exéresis con margen oncológico de la lesión en forma de coliflor y la electrofulguración, curetaje del resto de la lesión y tratamiento antimicótico. En un período de 5 meses el enfermo presenta evolución tórpida con toma del estado general y elefantiasis del miembro superior izquierdo hasta región supraclavicular que obliga a realizarle amputación interescapulotorácica por la técnica de Berger para mejorar la calidad de vida. El diagnóstico histopatológico de los paquetes ganglionares resecados mostró metástasis de un carcinoma epidermoide. Abstract in english The case of a 74-year-old white male patient with a hyperpigmented and verrucose dermatological injury of more than 25 years of evolution in his left elbow and forearm is reported. He also has another cauliflower-like skin injury of recent evolution. Both presented histopathological diagnosis of chr [...] omomycosis. The initial treatment was exeresis with oncological margin of the cauliflower-like injury and electrofulguration, curettage of the rest of the injury and antimycotic treatment. In 5 months, the patient had a torpid evolution with taking of the general state and elephantiasis of the upper left extremity to the supraclavicular region that led to the interscapulothoracic amputation by Berger’s technique to improve his quality of life. The histopathological diagnosis of the resected ganglionar packages showed metastasis of an epidermoid carcinoma.

Hiralio, Collazo Álvarez; Eridán, González Velázquez; Andrés G, Pardillo Morales; Stephen Yecc, Collazo Marín.

2001-12-01

256

Stereotactic radiotherapy of lung carcinomas with real time target tracking without fiducial; Radiotherapie stereotaxique de carcinomes pulmonaires avec suivi de la cible en temps reel sans fiduciel  

Energy Technology Data Exchange (ETDEWEB)

The authors discuss the results obtained on 51 patients treated with the Xsight Lung Tracking System (which do not need fiducial) for non-small-cell lung carcinomas. Results are analyzed and discussed in terms of gross tumour volume, session duration, survival rate by one year or two years, local control rate, later diagnosis (pneumopathy, lung fibrosis), and toxicity. These results suggest that this treatment mode could be an interesting option for non-operable patients. Short communication

Bibault, J.E.; Prevost, B.; Dansin, E.; Mirabel, X.; Lacornerie, T.; Lartigau, E. [Service universitaire de radiotherapie, centre Oscar-Lambret, Lille, (France)

2011-10-15

257

Management of Merkel cell carcinoma: Role of radiotherapy in elderly patients; Prise en charge des carcinomes a cellules de Merkel: place de la radiotherapie chez les patients ages  

Energy Technology Data Exchange (ETDEWEB)

Purpose Merkel cell carcinoma carcinoma (M.C.C.) or primary cutaneous neuroendocrine carcinoma is a rare and aggressive malignancy affecting elderly. Optimal therapeutic strategy has not yet been established in elderly patients. Patients and methods From March 1996 to March 2007, 29 patients with Merkel cell carcinoma of were treated at the University Hospital of Amiens, France. Adjuvant radiotherapy (R.T.) was performed for 14 patients (50%) on the tumor bed with margins of 3 to 5 cm, an average dose of 46 Gy (30-60 Gy), by 2 Gy per fraction. Ten of them also received R.T. to the lymph node area at mean dose of 44.3 Gy (26-50 Gy). Duration of R.T. was 35 days. A retrospective analysis was conducted to better evaluate survival and prognostic factors. Results Median overall survival (O.S.) was 18.9 months (3-122) and the median time to progression (M.T.P.) 5.5 months (1-26). At 5 years, O.S. for irradiated patients was 47% (IC95: 12-82%) versus 27% (IC95: 5-49%) in cases of surgery alone (p = 0.032). The most frequent sites of recurrence were nodal (34.5%), local (24.1%) and metastatic (17.2%). For patients over 70 years, eight (36.5%) were free of disease at last news, 8 (36.5%) had died from cancer and six from other causes (27%). In this subgroup, M.T.P. was 6 months (2-19) and median O.S. of 19 months (4-87). There was no acute toxicity greater than grade 2. Conclusion Although limited by a retrospective analysis, this report suggests an advantage of postoperative R.T. for patients with M.C.C.. It combined low toxicity and improvement of survival. Prospective multicenter trials are needed to clarify and validate the optimal strategy. (authors)

Assouline, A.; Krzisch, C. [CHU d' Amiens, Service de radiotherapie, hopital Sud, 80 - Amiens (France); Assouline, A.; Levy, A.; Mazeron, J.J. [Groupe hospitalier Pitie-Salpetriere, universite Paris-6, Service de radiotherapie, 75 - Paris (France); Mazeron, J.J. [Paris-6 Univ., 75 (France); Chargari, C. [Hopital d' instruction des armees du Val-de-Grace, Service de radiotherapie, 75 - Paris (France)

2010-01-15

258

Epidermoid carcinomas of the anal margin treated by curative goal irradiation; Carcinomes epidermoides de la marge anale traites par irradiation a visee curative  

Energy Technology Data Exchange (ETDEWEB)

Purpose: to evaluate the toxicity, the local control rate and the survival of patients suffering of an epidermoid carcinoma of the anal margin treated by curative and conservative irradiation. Conclusion: the excision should be reserved for small tumors away from the anal canal. The curative radiotherapy is recommended for the tumors with incomplete resection and for that ones of big volume or localised near the anal canal. (N.C.00.

Huguet, F.; Touboul, E.; Schlienger, M. [Hopital Tenon, 75 - Paris (France); Tiret, E.; Godeberge, P.; Contou, J.F. [Hopital Saint-Antoine, 75 - Paris (France); Soudan, D. [Institut Mutualiste Montsouris, 75 - Paris (France); Roseau, G. [Hopital Leopold-Bellan, 75 - Paris (France)

2009-10-15

259

Radiotherapy of maxillary sinuses carcinoma: state of art; Radiotherapie des carcinomes des sinus maxillaires: l'etat de l'art  

Energy Technology Data Exchange (ETDEWEB)

Maxillary sinus carcinomas are rare malignancies of the face, characterized by high local relapsing rate. Modalities of treatment are without consensus and respective roles of radiation therapy and surgery remain controversial. As those malignancies are often diagnosed at locally advanced stage, radiation therapy may frequently be used for patients having unresectable advanced disease. Nevertheless, surgery remains treatment of choice for more localized malignancies, in association with systematic postoperative radiotherapy. For those patients whose prognosis remains pejorative, it is necessary to precise the role of radiotherapy in first intention for inoperable tumors, to define necessity for nodal treatment performing and evaluate the place of neo-adjuvant or concomitant chemotherapy in a multimodal strategy. (authors)

Chargari, C.; Bauduceau, O.; Vedrine, L.; Fayolle, M.; Ceccaldi, B. [Hopital d' Instruction des Armees Val-de-Grace, Service d' Oncologie Radiotherapie, 75 - Paris (France); Chargari, C.; Magne, N. [Institut Gustave-Roussy, Dept. de Radiotherapie, 94 - Villejuif (France); Haen, P. [Hopital d' Instruction des Armees Begin, Service de Chirurgie Maxillofaciale et Plastique de la Face, 94 - Vincennes (France); Conessa, C. [Hopital d' Instruction des Armees Val-de-Grace, Clinique d' Otorhinolaryngologie et de Chirurgie Cervicofaciale, 75 - Paris (France)

2009-06-15

260

Chemoradiotherapy in head and neck squamous cell carcinoma: focus on targeted therapies; La chimioradiotherapie des carcinomes epidermoides des voies aerodigestives superieures: point sur les therapeutiques ciblees  

Energy Technology Data Exchange (ETDEWEB)

Radiotherapy is an essential treatment for many patients with head and neck squamous cell carcinoma. Its association with molecular targeted therapies represents a real progress. Among the recent advances in the molecular targeted therapy of cancer, the applications centred on E.G.F.R. are currently the most promising and the most advanced at clinical level. Considering the set of therapeutic tools targeting E.G.F.R., there are at present two well-identified emerging categories of drugs with monoclonal antibodies, on the one hand, and tyrosine kinase inhibitors, on the other. In many preclinical studies, the combination of anti-E.G.F.R. drugs with irradiation has led to additive or supra-additive cytotoxic effects. Furthermore, anti-angiogenic agents have shown promising results in association with anti-E.G.F.R. drugs and radiotherapy. This research effort has recently produced encouraging clinical results in advanced head and neck cancer with combination of cetuximab (an anti-E.G.F.R. monoclonal antibody) with irradiation with a significant impact on patient survival. Active and efficient clinical research is currently ongoing to determine the place of molecular targeted therapies in the treatment of head and neck cancer, particularly in association with radiotherapy. (authors)

Bozec, A. [Centre Antoine-Lacassagne, Dept. de Chirurgie, Institut Universitaire de la Face et du Cou, 06 - Nice (France); Thariat, J.; Bensadoun, R.J. [Centre Antoine-Lacassagne, Dept. de Radiotherapie, Institut Universitaire de la Face et du Cou, 06 - Nice (France); Milano, G. [Centre Antoine-Lacassagne, Unite d' Oncopharmacologie, Institut Universitaire de la Face et du Cou, 06 - Nice (France)

2008-01-15

261

Retrospective analysis of 108 ductal carcinomas in situ of the breast treated by radiosurgery association; Analyse retrospective de 108 carcinomes canalaires in situ mammaires traites par association radiochirurgicale  

Energy Technology Data Exchange (ETDEWEB)

Purpose. - To evaluate survival and prognostic factors of 108 patients with clinically or mammo-graphically detected ductal carcinoma in situ (DCIS), treated from 1980 to 1996 by complete local excision followed by external irradiation. Patients and methods. - The median age was 51 (range 37-80). All the patients underwent surgery consisting of a wide resection of the mammary gland harboring the tumour. The surgical specimens were sent to the pathologists to get information on histology and margin clearance; all the slides were reviewed by one of us to assess the tumoral diameter. External beam therapy was delivered within 8 weeks after surgery. The prescribed irradiation dose was 50 Gy in 25 fractions to be given in 5 weeks. The median duration of follow-up was 93 months (range 40-173). Results. - There were nine patients with local recurrence (8.3%); three patients had local recurrence of DCIS and six patients developed invasive breast cancer. The treatment of local recurrence consisted of mastectomy with or without axillary dissection (eight cases) and quadrant-ectomy (one case). The 5-year and 10-year ipsilateral recurrence-free rate was respectively 92 and 89%. The 10-year cause specific survival was 100%. In univariate analysis, size {>=} 10 mm, age < 45 years old and margin status were significant P = 0,02. P 0,03, P = 0,005; margin status was significant in multivariate analysis (P < 0,02). Conclusion. - These results are in keeping with those of the literature. They could be improved by the mass screening campaign, which is going on since January 1990 among women aged 50 - 74 years. (authors)

Fourneret, P.; Artignan, X.; Cornulier, J. de; Kolodie, H.; Vincent, F.; Colona, M.; Bolla, M. [CHU de Grenoble, Service de cancerologie-radiotherapie, 38 - Grenoble (France); Pasquier, D. [CHU de Grenoble, Service d' anatomopathologie, 38 - Grenoble (France); Bernard, P. [CHU de Grenoble, Service de gynecologie, 38 - Grenoble (France); Payan, R. [Clinique Belledone, 38 - Saint-Martin-D' Heres (France); Frice, D. [Clinique du Mail, 38 - Grenoble (France); Colona, M.; Bolla, M. [Office Dept. de lutte contre le cancer, 38 - Meylan (France); Panh, M.H. [Registre du cancer de l' Isere, 38 - Meylan (France)

2006-12-15

262

Surgery and chemo radiation in stage 3A non-small cell lung cancer; Chirurgie et chimioradiotherapie dans les carcinomes bronchiques de stade  

Energy Technology Data Exchange (ETDEWEB)

Combination of surgery and radiotherapy has become a standard regimen in multiple cancers. Because of its toxicity and the higher metastatic potential of lung cancer, leading to underestimate the impact of loco-regional treatments, this strategy is currently used only in a clinical trial setting. Recent results from phase III studies comparing surgery and radiotherapy in stage IIIA-N2 locally advanced non-small cell lung cancer after induction treatment showed that surgery should only be performed in patients presenting with a major mediastinal down-staging and possible curative resection within a lobectomy. In all other cases, exclusive chemo-radiation remains the therapeutic standard at the time. In this way, all patients with stage III non-small cell lung cancer may receive induction treatment, consisting either in chemotherapy or in sequential or concurrent chemo-radiation, which has shown its feasibility and its efficacy regarding tumor response, resectability and local control rates. These two induction regimens are currently compared in randomized trials including stage III resectable and unresectable tumors at time of diagnosis. These developments make treatment of locally advanced non-small cell lung cancer a model for multimodal strategies in oncology, combining chemotherapy, radiotherapy and surgery. (author)

Hennequin, C. [Hopital Saint-Louis, Service de Cancerologie-Radiotherapie, 75 - Paris (France); Girard, N.; Mornex, F. [Hopital Lyon-Sud, Service de Radiotherapie-Oncologie, 69 - Lyon (France)

2006-11-15

263

Pseudo-angiomatous liver metastasis of thyroid medullary carcinoma: multimodality diagnostic approach; Metastase hepatique pseudoangiomateuse d'un carcinome medullaire de la thyroide: approche diagnostique multimodalite  

Energy Technology Data Exchange (ETDEWEB)

Purpose: Illustrate the result of the diagnosis by multimodality imaging (MRI, scintigraphy {sup 123}I-Mibg, PET/CT{sup 18}F-F.D.G. and {sup 18}F-F DOPA) with liver metastasis looking like a single angioma in a patient with atypical medullary thyroid carcinoma. Conclusions: Angiomas must be taken into account in the differential diagnosis of liver metastasis of endocrine tumors, particularly in the case of small injuries where it may be difficult to differentiate a peripheral nodular contrast enhancement of a globular enhancement characteristics of angiomas. (N.C.)

Imperiale, A.; Keomany, J.; Rust, E.; Constantinesco, A. [CHU de Strasbourg, Service de biophysique et medecine nucleaire, 67 (France); Greget, M. [CHU de Strasbourg, Service de radiologie 1, 67 (France); Chabrier, G.; Goichot, B. [CHU de Strasbourg, Service de medecine interne, endocrinologie et nutrition, 67 (France); Detour, J. [CHU de Strasbourg, Service de radiopharmacie, 67 (France); Pessaux, P. [CHU de Strasbourg, Service de chirurgie generale, hepatique et endocrinienne, 67 (France)

2010-07-01

264

Age influence on naso-pharynx carcinomas prognosis after chemoradiotherapy; Influence de l'age sur le pronostic des carcinomes nasopharynges apres chimioradiotherapie  

Energy Technology Data Exchange (ETDEWEB)

The recurrence modes were not different before and after seventy years. The conformal radiotherapy in classical fractionation can be realised for subjects over 70. The triplets are not easily used in chemotherapy of induction after 70 years, as the concomitant chemotherapy by cisplatin. The optimization perspectives include targeted therapies, and the lympho-therapy anti-Epstein-barr virus, especially in the aged subpopulations. (N.C.)

Thariat, J.; Peyrade, F.; Marcy, P.Y.; Guevara, N.; Dassonville, O.; Doglio, A.; Benezery, K.; Ortholan, C.; Bensadoun, R.J.; Santini, J. [Centre Antoine-Lacassagne, 06 - Nice (France)

2009-10-15

265

Intra-arterial injection of 131-I-Lipiodol in the treatment of hepato-cellular carcinoma; Lipiocis et carcinome hepato-cellulaire  

Energy Technology Data Exchange (ETDEWEB)

The incidence of hepatocellular carcinoma (HCC) is increasing in developed countries and the general status of HCC patients is now by far better than a few years ago, allowing physicians to propose some different treatments of these patients. Among these treatments, intra-arterial injection of 131-iodine-labelled Lipiodol could be used in palliative, curative or adjuvant settings. After a brief summary of the modalities of this treatment, requiring the collaboration of Gastro-enterologists, Oncologists, Radiologists and Nuclear Medicine physicians, the different possibilities of therapeutic uses of this new approach are described and an outlook of these developments is proposed. (author)

Raoul, J.L. [Centre E. Marquis, 35 - Rennes (France)

2001-11-01

266

Trans-arterial chemo-embolization and conformal radiotherapy for hepatocellular carcinoma; Chimioembolisation et radiotherapie de conformation dans le traitement du carcinome hepatocellulaire  

Energy Technology Data Exchange (ETDEWEB)

Hepatocellular carcinoma is a poor prognosis tumour. The potential curative therapeutic options are ortho-topic liver transplantation, surgical resection and radiofrequency ablation. Unfortunately, only a minority of patients (around 20%) are eligible for these techniques. Thus, patients can benefit from palliative options, such as trans-arterial chemo-embolization (TACE) or sorafenib that bring only modest benefit on survival. Conformal radiotherapy allows delivering high dose radiation within a precise tumour volume while sparing the surrounding liver parenchyma. As employed in mono-therapy, conformal radiotherapy is highly efficient for small size hepatocellular carcinoma (< 5 cm). Above 5 cm, its efficacy is more limited but its association with TACE gives spectacular rates of complete responses. Controlled phase 2 or 3 trials are urgently warranted to define its indications in the therapeutic algorithm of hepatocellular carcinoma. (authors)

Merle, P. [Service d' hepatogastroenterologie, hopital de l' Hotel-dieu, 1, place de l' Hopital, 69002 Lyon (France); Inserm U871, equipe ' Oncogenese hepatique et hepatites virales' , 151, cours Albert-Thomas, 69003 Lyon (France); Universite Claude-Bernard Lyon 1, IFR62 Lyon-Est, 8, avenue Rockefeller, 69008 Lyon (France); Mornex, F. [Departement de radiotherapie-oncologie, centre hospitalier Lyon-Sud, chemin du Grand-Revoyet, 69310 Pierre-Benite (France); equipe ' Ciblage therapeutique par les agents physiques' , EA 37-38, universite Claude-Bernard Lyon 1, 43, boulevard du 11-Novembre-1918, 69622 Villeurbanne cedex (France)

2011-02-15

267

Fast neutron therapy of bronchus carcinoma: the pooled results from two european centres; Utilisation de neutrons rapides dans le traitement des carcinomes bronchiques. Experience de deux centres europeens  

Energy Technology Data Exchange (ETDEWEB)

The Berlin-Buch and Heidelberg centres used fast neutron therapy in bronchial carcinomas. The neutron source was a cyclotron in Berlin-Buch/Rossendorf and a d-t generator in Heidelberg. Three hundred twelve patients with inoperable bronchial carcinoma were treated with fast neutron therapy alone or in combination with photons. The results were then compared with those obtained from 594 patients treated only with photons. Altogether, 788 were treated in Berlin-Buch and 188 in Heidelberg. The results suggest that neutron therapy for bronchial carcinoma can be a good alternative in curative and palliative situations in the early stages. (author). 14 refs.

Lessel, A. [Humboldt-Universitaet, Berlin (Germany)

1996-12-31

268

Apport de la pathologie intégrative dans l'identification de biomarqueurs dans les carcinomes pulmonaires non à petites cellules : pathologie intégrative et cancer du poumon  

OpenAIRE

Le cancer pulmonaire non à petites cellules (CNPC) est la première cause de décès par cancer dans le monde. Ce cancer est souvent découvert tardivement, il est agressif, et il est chimio-résistant. La découverte de biomarqueurs pourraient représenter une percée majeure pour la prise en charge de ces patients, en facilitant le diagnostic, le pronostic et orienter vers le choix du traitement le plus approprié. Nous avons exploré plusieurs aspects liés à la progression tumorale dans...

Ilie, Marius Ionut

2013-01-01

269

Inoperable metastatic giant basal cell trunk carcinoma: radiotherapy can be useful; Carcinome basocellulaire geant du tronc metastatique inoperable: la radiotherapie peut etre utile  

Energy Technology Data Exchange (ETDEWEB)

The authors evoke some characteristics of the basal cell carcinoma (slow evolution, local morbidity) and report and discuss the case of a giant basal cell trunk carcinoma, associated with several symptoms (pain, bleeding, anaemia), already metastatic at the moment of diagnosis, and locally treated by irradiation. Due to its size and expansion, this carcinoma was considered as inoperable. An external radiotherapy has been performed and resulted in a significant clinical tumour reduction. But the metastatic risk is high in such cases. Radiotherapy is then a therapeutic option for a local treatment with a durable efficiency. Short communication

Mania, A.; Durando, X.; Lapeyre, M. [Centre Jean-Perrin, Clermont-Ferrand (France); Barthelemy, I. [CHU Estaing, Clermont-Ferrand (France)

2011-10-15

270

Post irradiation eardrum: a rare complication of the radiotherapy of naso-pharynx carcinomas; Necrose tympanique postradique: une complication rare de la radiotherapie des carcinomes nasopharynges  

Energy Technology Data Exchange (ETDEWEB)

The eardrum necrosis is a serious and dreadful complication but rarely described after irradiation of cavum cancers. We report in this work five cases of eardrum necrosis after radiotherapy of nasopharynx carcinomas. Patients and methods: between february 1993 and december 2004 239 patients suffering of anon metastatic nasopharynx cancer have been treated by classical irradiation associated or not to a chemotherapy. The radiotherapy was delivered at the dose of 70 to 75 Gy in the cavum and the ganglions initially reached according a classical modality of hyperfractionated one. We analysed retrospectively the delayed complications occurred six months or more after the radiotherapy beginning. Results: Five cases of eardrum necrosis were reported sixty five months after the end of radiotherapy. these patients suffered of hypoacusia and buzzing. The clinical examination allowed to bring out the eardrum perforation that did not exist before radiotherapy. The total dose of irradiation was 75 Gy for a patient and 71.5 Gy according a hyperfractionated modality for four patients. Three patients had an hearing prosthesis in order to improve their quality of life. Conclusion: the eardrum necrosis after radiotherapy for nasopharynx cancer is a rare and unusual complication, very few reported in the literature. The total dose of irradiation is considered as the principal factor of occurrence risk in such complication. (N.C.)

Siala, W.; Mnejja, W.; Daoud, J. [CHU Habib-Bourguiba, Service de Radiotherapie Oncologique, Sfax (Tunisia); Khabir, A. [CHU Habib-Bourguiba, Service d' Anatomopathologie, Sfax (Tunisia); Ghorbel, A. [CHU Habib-Bourguiba, Service d' ORL, Sfax (Tunisia); Frikha, M. [CHU Habib-Bourguiba, Service d' Oncologie Medicale, Sfax (Tunisia)

2009-10-15

271

Nasopharynx carcinomas. about 1342 cases treated at Oran, Algeria; Carcinomes du nasopharynx. A propos de 1342 cas traites a Oran, Algerie  

Energy Technology Data Exchange (ETDEWEB)

The purpose was to describe the epidemiology, clinical and therapy characteristics of the cavum cancer and the different post therapy results. The cavum cancer is frequent in west Algeria. It is the first cancer of superior aero digestive tracts, the fifth one fro man and the seventh for woman. It represents 8% of the whole of cancers treated at the radiotherapy service in Oran. It is chemosensitive and can be cured by radiotherapy but the frequency of locoregional recurrences and metastases remains high, despite all therapeutic methods used. (N.C.)

Khaldi, H.; Aid, M.; Lahmer, K.; Dali-Youcef, A.F. [Radiotherapie, Oran (Algeria)

2009-10-15

272

Contribution of radiotherapy in the treatment of cavum carcinomas at Yaounde; Apport de la radiotherapie dans le traitement des carcinomes du cavum a Yaounde  

Energy Technology Data Exchange (ETDEWEB)

A lot of works show that cavum carcinomas make of Cameroon an area at intermediary risks non negligible. The radiotherapy seems to be the only efficient technique but it is still non well known in our hospitals. This works wants to plaid in favor of its acknowledge and its optimal use by showing its contribution and its application difficulties. 5 refs., 1 tab.

Yomi, J.; Fouda, A.; Maloum, E.; Bengono, G.

1995-12-31

273

[Role of type IV collagene and type IV collagenase in the invasion and metastasis of salivary adenoid cystic carcinoma].  

Science.gov (United States)

Using immunohistochemical ABC method, the authors studied the distribution of type IV collagen and type IV collagenase in 25 cases ACC. The result showed type IV collagen was found in vascular and epithelial basement membrance, and in partly cyst of sieve-like and tubular pattern, and in cytoplasm of tumor cell. Type IV collagenase was detected in membrance and cytoplasm of tumor cell. Expression of type IV collagen and type IV collagenase were correlated with pathologic type, TNM stage and metastasis. Much positive staining of type IV collagen was found in sieve-tubular pattern, early stage of TNM and without metastasis, but much positive staining of type IV collagenase was found in solid pattern, later stage of TNM and metastasis. The result suggested that the loss of type IV collagen and over-expression of type IV collagenase may be markers of malignance of ACC. PMID:11480001

Shi, H; He, R; Lin, G

1997-08-01

274

Cirugía micrográfica de Mohs : Estudio retrospectivo de los últimos trece años (1999-2011) en el Hospital de la Santa Creu i Sant Pau  

OpenAIRE

L'objectiu d'aquest treball va ser descriure les característiques dels pacients tractats amb cirurgia microgràfica de Mohs entre 1999-2011 i avaluar l'eficàcia d'aquesta cirurgia per al tractament dels carcinomes basocel•lulars. Durant aquest període es van realitzar 560 cirurgies de Mohs, el 95.36% de les quals van ser de carcinomes basocel•lulars. Es va observar una taxa de recidiva del 1.40% per als carcinomes basocel•lulars primaris i del 13.62% per als recurrents, éssent la di...

Catala? Gonzalo, Alba

2013-01-01

275

Approche dynamique de la coopération d'altérations génétiques dans la tumorigenèse corticosurrénalienne  

OpenAIRE

Les anomalies moléculaires des tumeurs corticosurrénaliennes sporadiques, bénignes (adénomes corticosurrénaliens ; ACS) ou malignes (carcinomes corticosurrénaliens ; CCS), sont relativement bien caractérisées, tandis que leur implication dans chaque étape du processus de tumorigenèse, de l'initiation à la formation de tumeurs métastatiques, reste très peu connue. Nous ne savons également pas si les CCS et les ACS sont deux entités distinctes ou si les carcinomes font suite aux ...

Herbet, Maryline

2008-01-01

276

Oral Cancer Removal and Palate Reconstruction  

Medline Plus

Full Text Available ... Today, Dr. Browne is going to remove an adenoid cystic carcinoma from the hard palate… [clears throat]… ... to fill the defect. 00:06:37 Often, adenoid cystic carcinoma, the type of cancer that we’ ...

277

Tonsillectomy and Adenoidectomy  

Medline Plus

Full Text Available ... the mouth. The tonsils are part of the immune system and help fight infections. Eustachian tube The adenoids ... mouth. The adenoids are also part of the immune system and help fight infections. The uvula is also ...

278

Resection and Reconstruction of Maxillary Class IIIc Defect in a Case of Adenoid Cystic Carcinoma: Cost-Sensitive Technique without Microvascular Grafts.  

Science.gov (United States)

ACC is a rare malignant tumor that affects most commonly the major and minor salivary glands and rarely the paranasal sinuses, lacrimal gland, larynx, ear, vulva, and so forth. The maxillary sinus when affected is considered having a poor prognosis due to delayed diagnosis and delayed treatment credited to its slow spread, late symptoms, and complex anatomy which hampers surgical resection. The expressions of tumor markers too have a significant role in determining the prognosis. The treatment of choice consists of wide radical resection of the tumor followed by radiotherapy. Rehabilitation options in cases with huge maxillary defects still need further exploration. PMID:24069539

Adwani, Dwarkadas; Bhattacharya, Anirudh; Arora, Rajender Singh; Soni, Ramawatar; Adwani, Nitin

2013-01-01

279

Avaliação radiográfica da adenóide em crianças: métodos de mensuração e parâmetros da normalidade Radiographic evaluation of adenoidal size in children: methods of measurement and parameters of normality  

OpenAIRE

A radiografia da nasofaringe (ou radiografia do cavum) ainda é o exame por imagem mais usado para a avaliação do tamanho da adenóide. Dada a variedade e a complexidade dos métodos de mensuração preconizados, muitos radiologistas preferem a avaliação subjetiva, que pode ser imprecisa e não-acurada. Esta revisão enumera e descreve os diversos métodos de mensuração radiográfica da adenóide propostos na literatura, considerando praticidade, acurácia e precisão, com o objetivo de...

Severino Aires de Araújo Neto; Suélio Marinho de Queiroz; Emílio Carlos Elias Baracat; Inês Minniti Rodrigues Pereira

2004-01-01

280

Nasopharyngeal carcinoma. Clinical diagnosis, external radiotherapy and brachytherapy. Status of the art in 2001; Carcinomes du nasopharynx. Aspects cliniques, indications et resultats de la radiotherapie transcutanee et de la curietherapie. Etat de la question en 2001  

Energy Technology Data Exchange (ETDEWEB)

Nasopharynx carcinomas (NPC) are a very special head and neck cancer, in term of epidemiology, clinic and pathology. Endemic disease in South East Asia, undifferentiated nasopharynx carcinoma are very frequent CT scan and NMR allow a better knowledge of the modalities of the clinical presentation. Prognostic factors include local and regional extension. NPC is a well known radiosensitive disease with a dose-response curve well established. Modern imaging modalities and modification of the ballistic explain the amelioration of the local control and the diminution of therapeutic sequelae. Brachytherapy is an interesting modalities for the boost and the treatment of recurrent disease. The exact place of 3 D CRT and IMRT is not yet known as modifications of fractionation. Local control for T1 T2 tumor is excellent but is related to clinical extension (cranial and neurologic involvement) and nodal extension (supra clavicular N3) and show the interest of combined chemo-radiotherapy protocols. (authors)

Eschwege, F.; Bourkhis, J. [Institut Gustave Roussy, Dept. de Radiotherapie, 94 - Villejuif (France); El Gueddari, B. [Institut National d' Oncologie, Rabat (Morocco)

2001-11-01

281

Sentinel lymph node detection in oropharynx and oral cavity; Interet de la detection du ganglion sentinelle dans les carcinomes epidermoides de la cavite buccale et de l'oropharynx  

Energy Technology Data Exchange (ETDEWEB)

The sentinel lymph node (SLN) is the first lymph node draining the tumour. Aim of the study: To determine the negative predictive value of the SLN in the NO or NI squamous cell carcinomas (SCC) of the oral cavity or the oropharynx. Materials and method: SLN localization firstly requires a lymphoscintigraphy which is realised after four injections of radiolabelled colloids around the tumour. This scintigraphy allows a cutaneous marking of the SLN. Per operative detection of the SLN is performed with a detection probe. Results: One or more SLN have been localized in 20 of the 21 patients. No SLN was found in one patient whose tumour was a recurrence. (T2 NO MO) of a SCC of the oropharynx irradiated 3 years before. The failure rate of the method is 4,8% (1 false negative in 21 patients) and the false negative rate is 12,5% (1 false negative in 8 positive patients). This false negative patient had a T3 NO MO SCC of the oropharynx with a SLN found in level III, deep lateral cervical group. The neck dissection revealed one positive node in level lb, submandibular group, and 27 other nodes, all negative. The probability for the whole neck dissection to be negative when the SLN is negative (negative predictive value), is 92,3% (12/13) in our study. Conclusion: Our patient population is too small to obtain statistically significant conclusions. A maximum of 2 % of false negative patients is necessary to apply this method and avoid complete neck dissection in NO and NI tumours of the the oral cavity and the oropharynx with a negative SLN. (author)

Chesnay, E.; Bouvard, G. [Centre Hospitalier Universitaire, Service de Medecine Nucleaire, 14 - Caen (France); Benateau, H.; Halley, A.; Compere, J.F. [Centre Hospitalier Universitaire, Service de Chirurgie Maxillo-Faciale et Stomatologie, 14 - Caen (France); Babin, E.; Bequignon, A. [Centre Hospitalier Universitaire, Service de d' Oto-Rhino-Laryngologie et Chirurgie Cervico-Faciale, 14 - Caen (France); Comoz, F. [Centre Hospitalier Universitaire, Service d' Anatomo-Pathologie, 14 - Caen (France)

2004-03-01

282

Oesophageal squamous cell carcinoma Stade 3. State of surgery after radio chemotherapy (R.C.T.); Carcinomes malpighiens de l'oesophage de stade 3, place de la chirurgie apres chimioradiotherapie  

Energy Technology Data Exchange (ETDEWEB)

Neo-adjuvant chemoradiotherapy is the gold standard of the treatment of advanced oesophageal squamous cell carcinoma. The role of surgery L. chemoradiotherapy is still debated. Feasibility of curative resection depends on dose of radiotherapy, morbi-mortality rates, and nutrition status at the end of the protocol especially for non-responders patients. Adding surgery to radio-chemotherapy improves local tumour control but does not increase overall survival of patients with advanced oesophageal squamous cell carcinoma. According to the two randomized trials published on the subject, surgery is not recommended after chemoradiotherapy for responders. Recommendations of French National Thesaurus are: exclusive chemoradiotherapy as reference, oesophagectomy for residual tumour as alternative for operable patients. Surgery may be proposed for selected non-responders patients and some complete pathology response in expert center. (author)

Triboulet, J.P.; Mariette, C. [Hopital Claude-Huriez, Service de Chirurgie Digestive et Generale, 59 - Lille (France)

2006-11-15

283

Interest of a treatment combined by radioimmunotherapy and Avastin 1 in a murine model of thyroid medullary carcinoma; Interet d'un traitement combine par radioimmunotherapie et Avastin1 dans un modele murin de carcinome medullaire de la thyroide  

Energy Technology Data Exchange (ETDEWEB)

The objective of this study was to evaluate the efficiency and the toxicity of the association radioimmunotherapy and bevacizumab on a murine model grafted by the human line T.T. of thyroid medullar cancer. After results it appears that in pretreatment, bevacizumab (Avastin) improves the efficiency of radioimmunotherapy without increasing the toxicity face the radioimmunotherapy alone. (N.C.)

Salaun, P.Y.; Bodet-Milin, C.; Paris, F.; Frampas, E.; Sai Maurel, C.; Faivre Chauvet, A.; Barbet, J.; Kraeber Bodere, F. [Unite Inserm U892, Brest, (France)

2009-05-15

284

Endometrial carcinoma. Results of a series of 137 stage 1 TNM/UICC; Evaluation d`une serie de 137 carcinomes de l`endometre de stade 1 TNM/UICC  

Energy Technology Data Exchange (ETDEWEB)

From 1974 to 1993, 137 women suffering from endometrial carcinoma cT1Nx-0 M0 were entered into the study. The median age was 62 years (range: 39-85 years) and the median follow up was 67 months (range: 0-224 months). Surgery was performable in 132 women (96.35%). For cT1, the 5-year overall and specific survivals were 81.1 % and 84.5 %, respectively. The 10-year overall and specific survivals were 68,8 % and 82,2%, respectively. Concerning cT1pT1, the 5-year overall and specific survivals, were 83.9% and 87.4%. The 10-year overall and specific survivals were 71.1% and 85%, respectively. Historical grade, pelvic lymph node involvement and myometrial infiltration influence significantly the overall and specific survivals of cT1pT1 tumors. According to multivariate analysis, pelvic lymph node involvement was a powerful prognostic for both overall and specific survivals. If we rule out pelvic lymph node involvement, WHO histological grade was a significant prognostic factor. Combination of surgery and radiotherapy is still a common procedure for cT1 tumors. When surgery is done before radiotherapy, tailored irradiation may further take place, according to WHO histological grade and pelvic lymph node status. (authors)

Bolla, M.; Cornulier, J. de; Berland, E.; Colonna, M.; Artignan, X.; Vincent, F.; Kolodie, H.; Pasquier, D. [Centre Hospitalier Universitaire, 38 - Grenoble (France); Salvat, J. [Centre Hospitalier de Thonon-les-Bains, 74 (France)

1999-05-01

285

Neck dissection following chemo radiation for node positive head and neck carcinomas;Place du curage ganglionnaire apres chimioradiotherapie dans les carcinomes epidermoides des voies aerodigestives superieures avec atteinte ganglionnaire initiale (nasopharynx exclu)  

Energy Technology Data Exchange (ETDEWEB)

The optimal timing and extent of neck dissection in the context of chemo radiation for head and neck cancer remains controversial. For some institutions, it is uncertain whether neck dissection should still be performed up front especially for cystic nodes. For others, neck dissection can be performed after chemo radiation and can be omitted for N1 disease as long as a complete response to chemo radiation is obtained. The question is debated for N2 and N3 disease even after a complete response as the correlation between radiological and clinical assessment and pathology may not be reliable. Response rates are greater than or equal to 60% and isolated neck failures are less than or equal to 10% with current chemo radiation protocols. Some therefore consider that systematic up front or planned neck dissection would lead to greater than or equal to 50% unnecessary neck dissections for N2-N3 disease. Positron-emission tomography (PET) scanning to assess treatment response and have shown a very high negative predictive value of greater than or equal to 95% when using a standard uptake value of 3 for patients with a negative PET at four months after the completion of therapy. These data may support the practice of observing PET-negative necks. More evidence-based data are awaited to assess the need for neck dissection on PET. Selective neck dissection based on radiological assessment and preoperative findings and not exclusively on initial nodal stage may help to limit morbidity and to improve the quality of life without increasing the risk of neck failure. Adjuvant regional radiation boosts might be discussed on an individual basis for aggressive residual nodal disease with extra-capsular spread and uncertain margins but evidence is missing. Medical treatments aiming at reducing the metastatic risk especially for N3 disease are to be evaluated

Thariat, J. [Centre de lutte contre le cancer Antoine-Lacassagne, Dept. de Radiotherapie, Oncologie, 06 - Nice (France); IBDC CNRS UMR 6543, 06 - Nice (France); Thariat, J.; Marcy, P.Y.; Bozec, A.; Peyrade, F.; Hofman, P. [Universite de Nice-Sophia-Antipolis, 06 - Nice (France); Hamoir, M. [Cliniques universitaires Saint-Luc, UCL, Dept. de chirurgie ORL, Bruxelles (Belgium); Janot, F. [Institut Gustave-Roussy, Dept. de chirurgie ORL, 94 -Villejuif (France); De Mones, E. [CHU de Bordeaux, Dept. de chirurgie ORL, 33 - Bordeaux (France); Marcy, P.Y. [Centre de lutte contre le cancer Antoine-Lacassagne, Dept. de Radiologie, 06 - Nice (France); Carrier, P. [CHU de Nice, Dept. de Medecine Nucleaire, 06 - Nice (France); Bozec, I. [Centre de lutte contre le cancer Antoine-Lacassagne, Dept. chirurgie ORL, 06 - Nice (France); Guevara, J.; Santini, J. [CHU Pasteur, Dept. de chirurgie ORL, 06 - Nice (France); Albert, S. [CHU Bichat, Dept. de chirurgie ORL, 75 - Paris (France); Vedrine, P.O. [CHG Cannes, 06 (France); Graff, P. [Centre de Lutte Contre le Cancer Alexis-Vautrin, Dept. de chirurgie ORL, 54 - Nancy (France); Peyrade, F. [Centre de lutte contre le cancer Antoine-Lacassagne, Dept. d' Oncologie Medicale, 06 - Nice (France); Hofman, P. [CHU de Nice, Dept. de Pathologie clinique et experimentale, 06 - (France); Centre de lutte contre le cancer Antoine-Lacassagne, CHU et tumorotheque CHU-CLCC, 06 - Nice (France); Bourhis, J. [Institut Gustave-Roussy, Dept. de Radiotherapie-oncologie, 94 - Villejuif (France); Lapeyre, M. [Centre de lutte contre le cancer Jean-Perrin, Dept. de Radiotherapie-oncologie, 63 - Clermont-Ferrand (France)

2009-12-15

286

Basal cell carcinoma of the scalp after radiation therapy for tinea capitis: 33 patients; Carcinomes basocellulaires du cuir chevelu secondaires a une radiotherapie pour teigne: une serie de 33 malades  

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Occurrence of basal cell carcinoma (BCC) following radiotherapy for tinea capitis is well known. The aim of this study was to specify the clinical and histological features of these BCC seen in 33 patients (1995 000). Twenty seven men and six women were diagnosed with BCC. The age of onset varied between 32 an 62 years. Radiotherapy was received between 5 and 17 years of age. The interval between irradiation and the onset of carcinoma varied between 21 and 51 years. Total number of lesions was 55. Forty percent of BCC occurred on the occipital area, the number varied from 1 to 5 and the size from 2 to 45 mm. Clinically, the nodular type was found in 51% of cases. Pigment was present in 64% of cases. Histological study showed a nodular aspect in 76% and pigmentation in 63% of cases. Nodular and pigmented type were the predominant BCC occurring after radiotherapy for tinea capitis in our series. In the literature, BCC are the most frequent carcinomas occurring after radiotherapy (70-100%). Pigmentation was not described in other series. The nodular histological form was the most frequent. (author)

Mseddi, M.; Bouassida, S.; Marrekchi, S.; Khemakhem, M.; Gargouri, N.; Turki, H.; Zahaf, A. [Centre Hospitalier Universitaire Hedi Chaker, Service de Dermatologie, Sfax (Tunisia)

2004-08-01

287

Isolated relapse ganglions of epidermoid carcinomas of superior aero-digestive ways:Does the brachytherapy have its place; Recidives ganglionnaires isolees de carcinomes epidermoides des voies aerodigestives superieures: la curietherapie a-t-elle sa place?  

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The brachytherapy of isolated ganglions relapses of epidermoid carcinomas allows the ganglions control to three years in 25% of cases. Taking into account its toxicity (6% of deceases) and the unfavorable prognosis of the illness, a cervical ganglion surgery must be always preferred. (N.C.)

Bollet, M.; Lapeyre, M.; Marchal, C.; Hoffstetter, S.; Peiffert, D.; Luporsi, E.; Bey, P. [Centre Alexis-Vautrin, 54 - Vandoeuvre-les-Nancy (France)

1999-11-01

288

Long-term results and prognostic factors of squamous cell carcinoma of the anal canal treated by irradiation; Resultats a long terme et facteurs pronostiques des carcinomes epidermoides du canal anal traites par irradiation  

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Purpose To analyze the prognostic factors of loco regional control (L.R.C.), specific survival (S.S.) and sphincter conservation (S.C.) of patients treated by curative and conservative irradiation for an epidermoid cancer of anal canal in our institution. Patients and methods From 1976 to 2005, 286 patients (pts) were treated by exclusive radiotherapy (180 pts) or chemo-radiotherapy (106 pts) followed by a brachytherapy boost (233 pts) or external beam radiotherapy boost (24 pts). Forty-three pts were stage I, 154 stage II, 31 stage IIIA and 53 stage IIIB. Results The mean follow-up was 65 months (range: 1.3-250 months). The 5-years-overall survival and S.S. rates were 66.4% and 78.1% respectively. In multivariate analysis, tumor size (? 40 mm) [R.R. = 2.1], node involvement (R.R. = 2.4), and poor response (< 75%) to first course irradiation [R.R. = 1.9], local relapse (R.R. = 4.5) and distant metastases were factors of poor prognosis for S.S.. Five-years-L.R.C. were 71.5% (88% for stage I, 69% for stage II, 77%, for stage IIIA and 60% for stage IIIB). Prognosis factors of L.C.R. were tumor size (R.R. = 2.5), response to first course of irradiation (R.R. = 2.9). S.C. was 71% at 5 years. Prognosis factors of S.C. were tumor size (R.R. = 1.9) and response to first course of irradiation (R.R. = 2.4). Conclusion The results of this series are similar to those of the literature. As well as initial tumor extension, response to first course of irradiation was found as prognostic factor on L..R., S.S., S.C.. Our results are similar to other series and brachytherapy seems not to be deleterious. Its impact to local control remains to be evaluated. (authors)

Tournier-Rangeard, L.; Peiffert, D.; Lafond, C.; Mege, A. [Centre Alexis-Vautrin, Dept. de Radiotherapie et Curietherapie, 54 - Vandoeuvre-les-Nancy (France); Metayer, Y.; Marchesi, V.; Buchheit, I. [Centre Alexis-Vautrin, Dept. de Radiophysique, 54 - Vandoeuvre-les-Nancy (France); Uwer, L.; Conroy, T.; Kaminsky, M.C. [Centre Alexis-Vautrin, Dept. d' Oncologie Medicale, 54 - Vandoeuvre-les-Nancy (France)

2007-06-15

289

What extension evaluation before therapy have we to do in the nasopharynx cancers?; Quel bilan d'extension pretherapeutique faut-il faire dans les carcinomes du nasopharynx?  

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NMR imaging has proved its superiority on scanography in the study of limits and tumor extension and should be the first examination. The practice of of a scanography or cervical NMR should be the best mean of ganglions evaluation. As regards the extension evaluation at distance, it is recommended to require systematically a thorax radiograph and a bone scintigraphy for any patient. The liver echography is rather indicated among male patients, aged between 40 and 45 and having a stage 3 lymph node (according to the U.I.C.C. 1997 classification). (N.C.)

Elloumi, F.; Mnejja, W.; Siala, W.; Daoud, J. [Centre Hospitallie Universitaire Habib-Bourguiba, Service de Radiotherapie Carcinologique, Sfax (Tunisia); Hammami, B.; Ghorbel, M. [Centre Hospitallie Universitaire Habib-Bourguiba, Service ORL, Sfax (Tunisia); Frikhan, M. [Centre Hospitallie Universitaire Habib-Bourguiba, Service de Carcinologie Medicale, Sfax (Tunisia)

2007-11-15

290

Pulmonary carcinomas treated by Cyberknife: from synchrony to x sight lung, preliminary results for 30 patients; Carcinomes pulmonaires traites par cyberknife: du synchrony a l'xsight lung, resultats preliminaires chez 38 patients  

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The treatment of pulmonary carcinomas classified T1 or T2, without ganglions injury or at a distance, stays classically on surgery. this treatment is not always feasible in the context of patients with severe respiratory failure. The hypo fractionated stereotactic radiotherapy allows to propose a treatment to these patients. As conclusion: the stereotactic radiotherapy by Cyberknife allows to offer a well tolerated treatment to patients in whom surgery is impossible. (N.C.)

Bibault, J.E.; Le Tinier, F.; Prevost, B.; Lacornerie, T.; Lartigau, E. [Centre Oscar-Lambret, Dept. Universitaire de Radiotherapie, CyberKnife nord-ouest, 59 - Lille (France)

2009-10-15

291

Retrospective study of the local control and the cosmetic result of 147 face carcinomas after interstitial brachytherapy; Etude retrospective du controle local et du resultat cosmetique de 147 carcinomes de la face apres curietherapie interstitielle  

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The purpose was to evaluate retrospectively the local control rate and the cosmetic results for patients that received an interstitial brachytherapy for a base or spino-cellular carcinoma of face orifices areas. The interstitial brachytherapy by iridium 192 is an excellent alternative to surgery in the skin carcinomas of the face, as well at the level of local control as the cosmetic and functional results. (N.C.)

Ducassou, A.; David, I.; Bonnet, J.; Delannes, M. [Institut Claudius-Regaud, Service de Radiotherapie, 31 - Toulouse (France)

2009-10-15

292

Class T4 (Stage 3B) epidermoid carcinomas of the anal channel; Carcinomes epidermoides du canal anal classes T4 (stade 3B): traitement conservateur par irradiation ou irradiation preoperatoire  

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The local control rate with a correct anal function is low after radiotherapy with curative aim with or without concomitant chemotherapy. For the patients whom the tumoral response is under 50% after the first irradiation fractions and/or that have a bad anal function even before therapy (scores 3-4), the sphincter preservation is compromised and the conservative treatment is questionable. (N.C.)

Deniaud-Alexandre, E.; Touboul, E.; Huguet, F.; Pene, F.; Schlienger, M. [Hopital Tenon APHP, Service d' Oncologie-Radiotherapie, 75 - Paris (France); Tiret, E.; Parc, R. [Hopital Saint-Antoine, APHP, Service de Chirurgie Digestive, 75 - Paris (France); Sezeur, A. [Groupe Hospitalier des Diaconesses-Croix Saint-Simon, Service de Chirurgie Digestive, 75 - Paris (France); Hannoun, L. [Groupe Hospitalier Pitie-Salpetriere APHP, Service de Chirurgie Digestive, 75 - Paris (France); Houry, S. [Hopital Tenon APHP, Service de Chirurgie Digestive, 75 - Paris (France)

2006-11-15

293

Preoperative concomitant radio chemotherapy in bulky carcinoma of the cervix: Institut Curie experience; Chimioradiotherapie concomitante preoperatoire dans les carcinomes du col uterin de stades IB2 a IIB: experience de l'Institut Curie  

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Purpose: To evaluate the treatment results of patients (pts) with Figo stage IB2, IIA, IIB cervical carcinoma (C.C.) treated with preoperative radio chemotherapy, followed by extended radical hysterectomy. Patients and methods: Retrospective study of 148 women treated to the Curie Institute for operable Figo Stage IB2 to IIB, biopsy proved C.C.. Among them, 70 pts, median age 46 years, were treated using the same regimen associating primary radio cis-platinum based chemotherapy,intracavitary LDR brachytherapy, followed by extended radical hysterectomy. Kaplan-Meier estimates were used to draw survival curves. Comparisons of survival distribution were assessed by the log-rank test. Results: Complete histological local-regional response was obtained in 56% of the pts (n = 39). Residual macroscopic or microscopic disease in the cervix was observed in 28 pts (40%). All but one had in situ microscopic residual C.C.. Lateral residual disease in the parametria was also present in nine pts, all with residual C.C.. Pelvic lymph nodes were free from microscopic disease in 56 pts (80%). Eight of 55 (11%) radiological N0 patients had microscopic nodal involvement, as compared to 6/15 (40%) radiological N1 (p = 0.03). Seventeen pts (25%) had residual cervix disease but negative nodes. After median follow-up of 40 months (range, 8-141), 38/70 patients (54.1%) are still alive and free of disease, six (8.6%) alive with disease, and 11 (15.8%) patients were lost for follow-up but free of disease. Conclusion: The treatment of locally advanced C.C. needs a new multidisciplinary diagnostic and treatment approach using new therapeutic arms to improve the survival and treatment tolerance among women presenting this disease. (authors)

Kirova, Y.M.; Bourhaleb, Z.; Campitelli, M.; De la Rochefordiere, A. [Institut Curie, Groupe de Gynecologie, Service d' Oncologie et de Radiotherapie, 75 - Paris (France); Alran, S.; Fourchotte, V. [Institut Curie, Groupe de Gynecologie, Service de Chirurgie, 75 - Paris (France); Plancher, C. [Institut Curie, Groupe de Gynecologie, Service de Biostatistique, 75 - Paris (France); Beuzeboc, P.; Cottu, P. [Institut Curie, Groupe de Gynecologie, Service d' Oncologie Medicale, 75 - Paris (France); Petrow, P. [Institut Curie, Groupe de Gynecologie, Service de Radiologie, 75 - Paris (France); Cremoux, P. de; Sastre-Garau, X. [Institut Curie, Groupe de Pathologie, Service de Radiologie, 75 - Paris (France)

2009-07-15

294

Prognostic factors in the treatment of locally advanced hepatocellular carcinoma with radiotherapy and arterial infusion; Radiotherapie et chimiotherapie intra-arterielle des carcinomes hepatocellulaires localement evolues. Analyse des facteurs pronostiques  

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Prognostic factors in the treatment of local advanced hepatocellular carcinoma with radiotherapy, transcatheter arterial embolization and arterial infusion. The treatment effects of radiotherapy and combination modality therapy for the local advanced hepatocellular carcinoma (HCC) were retrospectively reviewed. Three hundred and fifty-six patients of HCC (187 recurrent cases after surgical resection) were treated by: radiotherapyonly ; bi-therapeutic method: hepatic artery ligation (HAL) and/or hepatic artery embolization (HAE) plus radiotherapy; and tri-therapeutic method (bi-therapeutic method plus hepatic artery infusion) from 1975 to 1996. Kaplan-Meier method has been used to evaluate the survival rates. There were no significant differences among these three treatment groups in the symptom relied rate, but the mean relief time period was much shorter in radiotherapy alone group (2.5 vs 44 months, P < 0.05). A lower tumor response rate was found in the radiotherapy alone group (P < 0.05), although that was similar for both primary or recurrent tumors (P > 0.05). There were evident differences in five-year survivals among these three treatment groups: 0 % for radiotherapy alone, 22.8 % for bi-therapeutic method and 38.8 % for tri-therapeutic method (P < 0.01). The prognosis was influenced by Okuda classification. Non-resectable local advanced HCC can be treated by the combination modality therapy, including radiotherapy, with a quite high cure rate. Radiotherapy alone can relief the symptoms. (authors)

Wang, Y.; Jin, Y.; Zhang, Z. [Hopital Changhai, Shanghai (China)

2000-06-01

295

Epidermoid carcinomas of the anal canal treated with definitive radiation therapy in a series of 305 patients; Carcinomes epidermoides du canal anal traites par irradiation a visee curative: a propos de 305 patients  

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Purpose. - To identify prognostic factors and treatment toxicity in a series of epidermoid cancers of the anal canal without evident metastasis. Patients and methods. - Between June 1972 and January 1997, 305 patients (pts) were treated with curative-intent radiation therapy (RT). The T-stages according to the 1987 UICC classification were: 26 T1, 141 T2, 104 T3, and 34 T4. There were 49 pts with nodal involvement at presentation. Pretreatment anal function scoring according to our in-house system was: 22 scored 0, 182 scored 1, 74 scored 2, 7 scored 3. 11 scored 4, and 9 not available pts. The treatment started with external beam RT (EBRT) in 303 pts (median dose: 45 Gy). After a rest period of 4 to 6 weeks, a boost of 20 Gy was delivered by EBRT in 279 pts and by interstitial {sup 192}Ir brachytherapy (Bcy) in 17 pts. Seven pts received only one course of EBRT (mean dose: 49.5 Gy) and 2 pts were treated with interstitial {sup 192}Ir Bcy alone (55 and 60 Gy, respectively). concomitant chemotherapy (5-fluoro-uracil and either mitomycin C or cisplatin) was delivered to 19 pts. Mean follow-up was 103 months. Results. - At the end of RT local tumor clinical complete response (cCR) rate was 80%. Out of 61 non responders or local progressive tumors 27 (44%) were salvaged with abdomino-perineal resection (APR). The rate of local tumor relapse (LR) was 12%. Out of 37 LTR, 20 (54%) were salvaged with APR and one with interstitial {sup 192}Ir Bcy. The overall local tumor control (LC) rate with or without salvage local treatment was 84%. LC rate with a good anal function scoring (score 0 and 1) was 56.5%0. Among 181/186 available pts who preserved their anus, 94% had a good anal function scoring. For a subgroup of 15 pts with length tumor <2 cm-N0, the LC rate after the end of RT was 100% the LC rate with or without local salvage treatment was 100%, and among 13 available pts who preserved their anus, the anal function scoring was good in 12 pts (92%). The 10-years disease-free survival was 74%. After multivariate analysis, 3 independent predicting factors significantly influenced the disease-free survival: gap duration between 2 courses of RT (>38 days vs {<=}38 days, P=0.0025), pretreatment anal function scoring (0 vs 1 vs 2 vs 3 vs 4, P =4.4 10{sup -6}), and cCR after the end of RT (no complete response vs complete response, P =2.5 10{sup -14}). Conclusion. - We confirm excellent results with RT in T1 and T2 lesions. However, chemoradiotherapy should be preferred to improves survival free. of colostomy with a good anal sphincter function for tumors more than or equal to 2 cm in length and locally advanced tumors. (author)

Deniaud-Alexandre, E.; Touboul, E.; Huang, R.; Qu, S.H.; Pene, F.; Schlienger, M. [Hopital Tenon, Service d' Oncologie-Radiotherapie, 75 - Paris (France); Tiret, E.; Parc, R. [Hopital Saint-Antoine, Service de Chirurgie Digestive, 75 - Paris (France); Sezeur, A. [Hopital des Diaconesses, Service de Chirurgie Generale, 75 - Paris (France); Houry, S. [Hopital Tenon AP-HP, Service de Chirurgie Digestive, 75 - Paris (France); Gallot, D. [Groupe Hospitalier Bichat-Claude-Bernard, Service de Chirurgie Generale et Digestive B, 75 - Paris (France)

2003-08-01

296

Hyperfractionated reirradiation following salvage surgery in 14 patients with head and neck cancer. Result of a pilot study; Reirradiation hyperfractionnee apres chirurgie de rattrapage de carcinomes cervicaux-faciaux. Resultat d`une etude pilote de 14 patients  

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Hyperfractionated reirradiation following salvage surgery in 14 patients with head and neck cancer. Result of a pilot study. Purpose: Between november November 1998 and May 1992, 14 patients were enrolled in a pilot study to evaluate the feasibility and results of hyperfractionated reirradiation for the treatment of head and neck recurrences or of second primary tumors developed in a previously irradiated volume. Materials and methods: All patients underwent a surgical resection for the treatment of their recurrence or second cancer. Reirradiation was proposed because of positive margins and/or lymph node metastasis with extra-capsular spread. The planned reirradiation dose was 60 Gy over 5 weeks, with two daily fractions of 1.2 Gy delivered 6-8 hours apart. Results: Of the 14 patients, 10 received the reirradiation scheduled dose (i.e., 60 Gy). All patients experienced an acute mucositis that never led to disruption of the treatment. Ten patients died 3 to 41 months after reirradiation (mean: 14 months), three were disease-free 48 to 71 months after reirradiation and one was alive with local progressive disease 74 months after reirradiation. The overall local control rate within the re-irradiated volume was 43 %. The 24- and 36-month overall survival rates were 50 and 35 %, respectively. Overall, 13 late complications were noted: four were grade 1, seven were grade 2, and two were grade 3. Three patients still alive in September 1993 and whose initial files were available were enrolled in an additional study to assess from dose-volume histograms the cumulative doses delivered by the two irradiations. (author). 53 refs.

Benchalal, M. [CHI de Montfermeil, 93 - Montfermeil (France); Bachaud, J.M.; Alzieu, C.; Giraud, P.; Daly-Schveitzer, N. [Centre Claudius-Regaud, 31 - Toulouse (France)

1997-09-01

297

Preoperative scintigraphic detection of lung metastases of a follicular thyroid carcinoma associated with hyperthyroidism; Detection scintigraphique preoperatoire de metastases pulmonaires d'un carcinome vesiculaire de la thyroide associe a une hyperthyroidie  

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Preoperative accumulation of radioiodine in metastases of thyroid carcinoma and its association with hyperthyroidism are uncommon. We report a case of 58-year-old woman with follicular thyroid carcinoma revealed by thyrotoxicosis caused by a hot nodule, and bilateral pulmonary uptake of I-131 before total thyroidectomy. Despite four ablative doses of I-131, bone metastases were identified and the patient died 42 month after the initial diagnosis. (authors)

Biyi, A.; Oufroukhi, Y.; Doudouh, A. [Hopital Militaire d' Instruction Mohammed V, Rabat Instituts, Service de Medecine Nucleaire, Rabat (Morocco); Baizri, H.; El Quatni, M. [Hopital Militaire d' Instruction Mohammed V, Service d' Endocrinologie, Rabat (Morocco); Al Bouzidi, A. [Hopital Militaire d' Instruction Mohammed V, Service d' Anatomie Pathologique, Rabat (Morocco)

2009-10-15

298

{sup 99m}Tc-HMDP uptake mechanism in calcified transitional cell carcinoma; Mecanisme de fixation du {sup 99m}Tc-HMDP sur les carcinomes urotheliaux calcifies de vessie  

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We report a case of transitional cell carcinoma of the bladder visualized on a {sup 99m}Tc-HMDP bone scintigraphy. CT demonstrated irregular tumor of the bladder with curvilinear calcifications on the surface areas and multiple bilateral pulmonary metastases. Bone scintigraphy showed intense uptake corresponding to the bladder tumor and two bone metastases on the left femur. A few days later, the patient underwent retrograde injection of {sup 99m}Tc-HMDP into the bladder. Imaging made after voiding showed a tumour uptake of the skeletal labelled agent. Through this case report, we debate {sup 99m}Tc-bi-phosphonate uptake mechanisms in transitional cell carcinoma. (authors)

Biyi, A.; Doudouh, A.; Oufroukhi, Y. [Hopital Militaire d' Instruction Mohammed-V, Service de Medecine Nucleaire, Rabat (Morocco); El Abbar, M. [Hopital Militaire d' Instruction Mohammed-V, Service d' Urologie, Rabat (Morocco); Al Bouzidi, A. [Hopital Militaire d' Instruction Mohammed-V, Service d' Anatomie Pathologique, Rabat (Morocco)

2009-02-15

299

The value of skeletal scintigraphy in the clinical follow-up of carcinomas of the uterine body and cervix. Die Wertigkeit der Skelettszintigraphie in der Nachsorge des Corpus- und Collum-Carcinoms  

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The study is based on a survey of 235 patients. A total of 139 women suffered from cervical carcinomas, which were accompanied by a second tumour in 16 cases, and malignancy of the body of the uterus was seen in 96 patients, 17 of whom displayed an additional carcinoma. The rate of uterine carcinomas metastising into the skeleton was calculated to be 4.3% or 4.8%. On an average, the diagnosis was proven one year after the discovery of malignant uterine changes. Measurements of alkaline phosphatase to test for the presence of skeletal metastases led to false-negative results in a large percentage of cases. In 139 patients the radionuclide was seen to accumulate in tissues other than the bones, which in 122 cases were the renal region and efferent urinary passages. Results obtained by more specific methods of examination were contrasted with the bone scintigrams and confirmed the previous diagnosis for 40 of those 122 patients (33%). In 11 of 18 patients (58%), where high density areas were detected in organs not belonging to the renal and urinary systems, the diagnosis suggested by the skeletal scientigrams could likewise be confirmed by further procedures. The findings revealed here would appear to suggest that radionuclide examinations of the skeleton are no longer advisable as a routine procedure in the follow-up of asymptomatic patients treated for uterine carcinomas. Quite apart from the low rate of skeletal metastases and uncertainties surrounding their treatment, some consideration must be given to the fact that a major part of presumptive diagnoses based on skeletal scintigrams are still eluding further verification. (orig./MG).

Thaler, B.

1989-06-01

300

Prospective study of accelerated postoperative radiation therapy in patients with squamous-cell carcinoma of the head and neck; Radiotherapie externe acceleree postoperatoire des carcinomes epidermoides localement evolues de la sphere ORL: etude prospective de phase 2  

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Purpose. - To assess the feasibility and efficacy of accelerated postoperative radiation therapy (RT) in patients with squamous-cell carcinoma of the head and neck (SCCHN). Patients and methods. - Between December 1997 and July 2001, 68 patients (male to female ratio: 52/16; median age: 60-years (range: 43-81)) with pT1-pT4 and/or pN0-pN3 SCCHN (24 oropharynx, 19 oral cavity, 13 hypopharynx, 5 larynx, 3 unknown primary, 2 maxillary sinus, and 2 salivary gland) were included in this prospective study. Postoperative RT was indicated because extra-capsular infiltration (ECT) was observed in 20 (29%), positive surgical margins (PSM) in 20 (29%) or both in 23 patients (34%). Treatment consisted of external beam R 66 Gy in 5 weeks and 3 days. Median follow-up was 15 months. Results. -According to CTC 2.0, acute morbidity was acceptable: grade 3 mucositis was observed in 15 (22%) patients, grade 3 dysphagia in 19 (28%) patients, grade 3 skin erythema in 21 (31%) patients with a median weight loss of 3.1 kg (range: 0-16). No grade 4 toxicity wa observed. Median time to relapse was 13 months; we observed only three (4%) local and four (6%) regional relapses, whereas eight (12%) patients developed distant metastases without any evidence of locoregional recurrence. The 2 years overall-, disease-free survival, an actuarial locoregional control rates were 85, 73 and 83% respectively. Conclusion.- The reduction of the overall treatment time using postoperative accelerated RT with weekly concomitant boost (six fraction per week) is feasible with local control rates comparable to that of published data. Acute RT related morbidity is acceptable. (author)

Zouhair, A.; Coucke, P.A.; Azria, D.; Moeckli, R.; Mirimanoff, R.O.; Ozsahin, M. [Centre Hospitalier Universitaire Vaudois CHUV, Service de Radio-Oncologie, Lausanne (Switzerland); Azria, D. [Centre Regional de Lutte Contre le Cancer Val-d' Aurelle-Paul-Lamarque, Dept. d' Oncologie- Radiotherapie, 34 - Montpellier (France); Pache, P. [Centre Hospitalier Universitaire Vaudois CHUV, Service d' ORL, Lausanne (Switzerland); Stupp, R. [Centre hospitalier Universitaire Vaudois CHUV, Centre Pluridisciplinaire d' Oncologie Medicale, Lausanne (Switzerland)

2003-08-01

301

Influence of MRI abnormality in skull base bone on prognosis of nasopharyngeal carcinoma; Influence de l'atteinte asseuse de la base du crane par IRM sur le pronostic des carcinomes nasopharynges  

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Purpose. To evaluate the influence of skull base bone (SBB) abnormality showed by MRI on prognosis of nasopharyngeal carcinoma (NPC). Patients and methods. From March 1993 to December 1998, 122 NPC patients received prime radiotherapy treatment. All of them were proved pathologically and checked by magnetic resonance imaging (MRI). Every patient received radiation through conjoint facio-cervical field and conventional dose-fractionation schedules. The total dose to the primary tumor was 60 5 Gy (median, 70 Gy). The Kaplan Meier method, the Log-rank test and the Cox regression model were used to evaluate the significance of prognostic factors on NPC patient survival. Results. The overall median survival period was 50 (6 2) months, and the 1, 3 and 5 year-survival rates were, respectively, 99.2%, 87.9%, and 73.3%. The 1, 3, and 5 year-survival rates of abnormality and normality of the SBB on MRI were 98.9%, 87.2%, 71.9%, and 100.0%, 89.8%, 77.0%, respectively (P 0.4233). Gender, age, head pain, SBB abnormality, cranial nerve palsy, cervical lymphadenopathy and primary tumor extent were analyzed with the Cox regression model and SBB abnormality on MRI did not prove to have statistical significance (P = 0.6934). According to the analysis of regrouping, patients with SBB abnormalities {>=} sites have a worse prognosis (P = 0.0427). Then. the above seven factors are analyzed by Cox regression model and the result had statistical significance (P = 0.0385). Conclusion. The SBB abnormality on MRI is of no obvious influence on prognosis of NPC. However, when SBB abnormality sites were {>=} 2, there is obvious statistical significance on the prognosis. (author)

Jin-Cheng, Lu; Qing, Wei; Yi-Qin, Zhang; Feng, Li [Jiangsu Cancer Hospital, Dept. of Radiotherapy, Nanjing (China)

2004-08-01

302

Dealing with initial chemotherapy doses: a new basis for treatment optimization in limited small-cell lung cancer; Importance de la dose initiale de chimiotherapie dans le traitement des carcinomes bronchiques a petites cellules: perspectives therapeutiques  

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Treatment of patients with small-cell lung cancer (SCLC) remains disappointing despite high initial complete response rates. The dramatic initial chemosensitivity of tumor cells is frustrated by the early emergence of chemoresistant clonogenic cells, regardless of front line treatments. Although the dose relationship is fairly well established regarding the response rate, its effect on survival is inconclusive. From 1980 to 1988, 202 patients with limited SCLC were included in four consecutive protocols using an alternating schedule of thoracic radiotherapy and chemotherapy. Despite an increase of chemotherapy and/or total radiation doses, no significant difference was observed between the four protocols in terms of response rate, disease free and overall survival. However, a retrospective analysis performed on a total of 131 consecutive patients led us to propose the hypothesis that a moderate increase in the initial dose, ie first course, of cisplatin and cyclophosphamide could improve overall survival. From 1988 to 1991, 105 patients were subsequently included in a large randomized trial raising this question. The treatment difference only concerned the initial doses of cisplatin (80 vs 100 mg/m{sup 2}) and cyclophosphamide (900 vs 1200 mg/m{sup 2}). The trial was closed after inclusion of 105 patients, 32 months after the start of the study because at that time overall survival was significantly better in the higher-dose group (p = 0.001). The emergence of this debatable concept opens new directions in the therapeutic strategy of SCLC and the contribution of hematopoietic growth factors may be a great interest in the management of this disease. (authors). 27 refs., 1 tab.

Le Chevalier, T.; Le Cesne, A.; Arriagada, R. [Centre de Lutte Contre le Cancer Gustave-Roussy, 94 - Villejuif (France)

1995-12-31

303

Treatment of hepatocellular carcinoma by intra-arterial injection of {sup 131}I labeled iodized oil (Lipiocis); Traitement des carcinomes hepatocellulaires par injection intraarterielle hepatique d`huiles iodees radiomarquees (Lipiocis)  

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When injected into the hepatic artery of patients with hepatocellular carcinoma (HCC), Lipiodol was demonstrated to remain selectively for a long time within the tumors. Biodistribution studies have shown that 80% of Lipiodol was retained by the liver, with a tumor/liver ratio of 4,5 and an effective half life of 5,5 d. The injection of a therapeutic activity (2,2 GBq) was well tolerated and associated with a response rate of 40%. Thereafter two phase II trials were initiated. In the first one the survival rate of HCC patients with portal vein thrombosis treated with Lipiocis was demonstrated to be significantly longer than that of a control group. In the second study, comparing Lipiocis to chemoembolization, preliminary results have shown that both treatments were as effective but that Lipiocis was significantly better tolerated than chemoembolization. (author). 7 refs., 2 figs.

Raoul, J.L. [Centre Eugene-Marquis, 35 - Rennes (France)

1995-12-31

304

Results of conservative treatment with surgery and radiation therapy of 132 non-palpable ductal carcinomas in situ of the breast; Resultats du traitement par chirurgie conservatrice et irradiation de 132 carcinomes canalaires in situ non palpables du sein  

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Retrospective analysis of results of treatment of 132 subclinical ductal carcinomas in situ, non-palpable. Patients were treated with limited surgery and 70 Gy radiation therapy (70 Gy). With a median follow-up of 7 years, the total recurrence rate was 6 % and the actuarial rate at 5 years 4 % and at 10 years 13 % at. These have no influence on recurrence on the specific actuarial survival rate which was 100 % at 10 years. In spite of five infiltrating recurrences of seven, no metastasis appeared 48 months after the salvage surgery. The global rate of breast. The global rate of breast preservation was 92 % at 7 years. Therapeutic indications were developed taking into account the present analysis and a literature review (2,338 in situ ductal carcinomas, palpable or not, treated with conservative surgery, with or without adjuvant radio-therapy). (author)

Amalric, R.; Brandone, H.; Dubau, A.; Hans, D.; Brandone, J.M.; Robert, F.; Pollet, J.F.; Amalric, F.; Rouah, Y.; Thomassin, L.; Giraud, D.; Henric, A.; Martin, P.M.; Romain, S. [Academie mediterraneenne d`oncologie clinique, Polyclinique Clairval, 13 - Marseille (France)

1998-01-01

305

Radio-induced glioblastoma and myxoma after treatment of undifferentiated carcinoma of the nasopharynx; Glioblastome et myxome radio-induits apres traitement d'un carcinome indiffencie du nasopharynx  

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Radio-induced tumor have been known for a long time to occur after treatment of cancer during childhood. This entity is exceptional following radiotherapy of the cavum. Skull and facial osteosarcoma were described after treatment of UCNT. We report two observations of radio-induced tumors arising respectively three and seven years after treatment of UCNT. The first one is a temporo-parietal glioblastoma and the second is a rhino- and pharyngeal myxoma. The two patients are alive after treatment of the second tumor. The delay of appearance of these tumors, their situation in the field's irradiated and dose received suggests their radioinduced nature. However, the cytogenetic study is necessary to confirm the implication of radiotherapy in the genesis of these cancers. (authors)

Daoud, J.; Ben Salah, H. [Centre Hospitalier Universitaire Habib-Bourguiba, Service de Carcinologie-Radiotherapie, Sfax (Tunisia); Kammoun, W.; Ghorbel, A.; Drira, M.M. [Centre Hospitalier Universitaire Habib-Bourguiba, Service ORL, Sfax (Tunisia); Frikha, M. [Centre Hospitalier Universitaire Habib-Bourguiba, Service de Carcinologie Medicale, Sfax (Tunisia); Jlidi, R. [Centre Hospitalier Universitaire Habib-Bourguiba, Lab. d' Anatomo-Pathologie, Sfax (Tunisia); Besbes, M.; Maalej, M. [Institut Salah-Azaiz, Service de Carcinologie-Radiotherapie, Tunis (Tunisia)

2000-12-01

306

Re-irradiation in stereotactic conditions and cetuximab for local relapses of epidermoid carcinoma of head and neck; Reirradiation en conditions stereotaxiques et cetuximab pour des recidives locales de carcinome epidermoide de la tete et du cou  

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The authors report a work aimed at assessing the feasibility and toxicity of a re-irradiation treatment in stereotactic conditions using CyberKnife and cetuximab in the case of local relapses of epidermoid cancers of the ORL sphere. Thirty three patients have been submitted to this treatment between June 2007 and April 2009. Although six patients died by six months, this treatment seems to be a good alternative, and presents an acceptable short-term toxicity. Further studies are needed to compare this technique to other therapeutic techniques, and to assess the risk of long term complications. Short communication

Vasseur, F.; Comet, B.; Faivre-Pierret, M.; Coche-Dequeant, B.; Degardin, M.; Lefebvre, J.L.; Lacornerie, T.; Lartigau, E. [Departement universitaire de radiotherapie, centre Oscar Lambret, 59 - Lille (France); Universite Lille-2, 59 (France)

2010-10-15

307

The place of radiotherapy in muco-epidermoid carcinomas of salivary glands in child; Place de la radiotherapie dans les carcinomes mucoepidermoides des glandes salivaires de l'enfant  

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As muco-epidermoid carcinomas are the most frequent tumours of salivary glands for child, the authors report the study of the role of radiotherapy. This study is based on a survey performed in 34 paediatric departments. The authors analyse the age and gender, the use of irradiation, the tumour location, the tumour grade and size, the use of surgery and of radiotherapy, and survival. Radiotherapy is beneficial for high grade tumours, but cannot be recommended for low and intermediate grades. Short communication

Thariat, J. [Centre Antoine-Lacassagne, Nice (France); Temam, S. [Institut Gustave-Roussy, Villejuif (France); Orbach, D. [Institut Curie, Paris (France); Nicollas, R.; Penicaud, M. [Hopital La Timone, Marseille (France); Toussaint, B. [CHU, Nancy (France); Makeieff, M. [CHU, Montpellier (France); Laprie, A. [Institut Claudius-Regaud, Toulouse (France); Castillo, L. [CHU, Nice (France); Vedrin, P. [CHC de Cannes, Cannes (France)

2011-10-15

308

Significado clínico-patológico das expressões citofotométricas do Ki-67 e Caspase-3 no carcinoma de células escamosas do esôfago Clinicopathologic significance of the Ki-67 and Caspase-3 cytophotometric expressions in the esophageal squamous cell carcinomal  

Directory of Open Access Journals (Sweden)

Full Text Available RACIONAL: A escolha da forma de tratamento do carcinoma de células escamosa de esôfago ainda hoje é orientada pelo estadiamento tumoral, onde as características histopatológicas do tumor são o maior determinante. Parale-lamente, desenvolvem-se estudos para entender o comportamento da biologia tumoral por método imunoistoquímico de quantificação manual, avaliando a ati-vidade proliferativa ou apoptótica do tecido em análise. As desvantagens conti-das no modo manual fizeram surgir e desenvolver método computadorizado de análise de imagem. OBJETIVOS: Verificar as expressões dos marcadores KI-67 e Caspase-3 e correlacioná-las com as características clínico-patológicas do tumor. MÉTODOS: Foram estudados 29 blocos parafinados provenientes de pa-cientes portadores de carcinoma de células escamosas de esôfago submetidos à esofagectomia e pertencentes a acervos de laboratórios de patologia. Proce-deu-se preparo das lâminas por técnica imunoistoquímica convencional. A quantificação da imunorreatividade às proteínas Ki-67 e Caspase-3 foi realizada pelo software de análise de imagem computadorizada SAMBA (Systeme d'Analyse Microphotometrique a Balayage Automatique através do índice de marcagem encontrado. RESULTADOS: Predominaram na amostra o sexo mascu-lino (82,7%; maiores de 50 anos; tumores moderadamente diferenciados (68,98%; estágio III (72,42%; lesões >3cm e localizadas no ? inferior do ór-gão. Os índices médios de marcagem identificados foram de 62,05% para o Ki-67 e 86,06% para a Caspase-3, e não mostraram correlação com as caracterís-ticas clínico-patológicas como sexo, idade, estadiamento tumoral, grau de pro-fundidade da lesão e comprometimento linfonodal. Houve significante diferença de expressão do Ki-67 entre os graus histológicos (P=0,047 e correlação entre os índices dos marcadores estudados (r=0,41 e P =0,032. CONCLUSÃO: Na presente investigação as atividades das proteínas estudadas se mostraram in-tensas sendo que a da Caspase-3 foi superior ao Ki-67 mas sem correlação com as características clínico-patológicas.BACKGROUND: The esophageal squamous cell carcinoma treatment strategy is still based on the tumor staging, where tumor histopathologic charac-teristics are the major determinants. In parallel, studies have been developed in order to better understand the tumor biology using immunohistochemical meth-ods with manual quantification evaluating the proliferative and apoptotic activi-ties of the cells. The disadvantages related to the manual method rose the de-velopment of computerized ways to do the image analysis. OBJETIVES: To verify the expressions of the markers Ki-67 (proliferative and Caspase-3 (apoptotic and to correlate them with the clinic and pathologic characteristics of the tumor. METHODS: Twenty-nine paraffin embedded blocks were studied, each one con-taining tissue samples from patients with esophageal squamous cell carcinoma submitted to esophagectomies. The clinic and pathological data were obtained from histopathologic informations and from medical records. The slides were prepared following the routine immunohistochemical method until the point to utilize the specific antibodies (MIB-1 and CPP32. Positive quantification of the immunoreactivity to the proteins Ki-67 and Caspase-3 was performed by the software for computerized image analysis SAMBA (Systeme d' Analyse Micro-photometrique a Balayage Automatique. Statistical analysis was done having P3cm; and lesions located in the lower third of the organ. The mean score indexes found were 62.05% for Ki-67 and 86.06% for Caspase-3 and there was no correlation with the clinic or pathologi-cal characteristics as gender, age and tumor staging. There was significant dif-ference of Ki-67 expression among the histological grades (P=0.047 and corre-lation between the evaluated indexes (r=0.41 and P=0.032. CONCLUSION: The protein expressions were high and the Caspase-3 protein activity was higher than the Ki-67, without correlation with clinic or pathological characteris

Gilmar Pereira Silva

2008-06-01

309

Virus del papil.loma humà com a factor pronòstic en les neoplàsies malignes de la vulva i de la vagina  

OpenAIRE

[cat] El Virus del Papil•loma Humà (VPH) està implicat en la patogènesis dels tumors del tracte genital femení i es detecta en la pràctica totalitat dels carcinomes de cèrvix, considerant-se una causa necessària per al seu desenvolupament. El VPH també sembla estar involucrat en una proporció de tumors de la vulva i de la vagina, però al contrari que en el cèrvix, els carcinomes escamosos de la vulva (CEV) i de la vagina (CEVa) es desenvolupen seguint dues vies etiopatogèniques ...

Fuste? Chimisana, Maria Victo?ria

2012-01-01

310

A report of laryngeal adenocystic carcinoma metastatic to the spleen and the role of splenectomy in the management of metastatic disease: a case report  

OpenAIRE

Abstract Introduction Adenoid cystic carcinoma (ACC) of the larynx is a rare malignancy characterized by an indolent course and late pulmonary metastases. Metastases from the larynx to the spleen are an unusual event. In the present report, we discuss a patient with adenoid cystic carcinoma of the larynx metastatic to the spleen. A review of the literature did not yield any other such incidents. We review the clinical presentation and course of adenoid cystic carcinoma, as we...

Murray Bryce W; Lyons Lewis C; Mancino Anne T; Huerta Sergio

2010-01-01

311

Hydatidose cardiaque et rénale - apport de l'imagerie à propos d'une observation  

Science.gov (United States)

L’échinococcose cardiaque est rare, elle représente 0.2 à 2% des cas d'hydatidose. Elle siège essentiellement au niveau du ventricule gauche. La localisation péricardique est exceptionnelle. L’échocardiographie et la tomodensitométrie jouent un rôle primordial et sont généralement suffisantes pour poser le diagnostic de cette affection. Nous rapportons une observation d'une association de deux localisations peu courantes d'hydatidose rénale et péricardique partiellement rompu et l'intérêt de l'imagerie dans le diagnostic de ces lésions kystiques. PMID:25419291

El Kharras, Abdennassar; Atmane, Mehdi; El Fenni, Jamal; Chaouir, Souad; Amil, Touria

2014-01-01

312

Modalidad quirúrgica como alternativa en la otitis media serosa por hipertrofia adenoidea: Pinar del Río, 2008 An alternative surgical method in the serous otitis media due to adenoid hypertrophia: Pinar del Rio, 2008  

OpenAIRE

La hipoacusia tiene repercusión negativa en el aprendizaje y comportamiento social de los niños, por lo que se hace necesaria la aplicación de técnicas quirúrgicas cada día más eficientes que reduzcan esta problemática. Con el objetivo de demostrar la eficacia de una nueva modalidad quirúrgica consistente en realizar adenoidectomía y doble miringotomía con aspiración del contenido seromucoso y de proponer una estrategia para solución quirúrgica definitiva en el nivel secundario ...

Fidel Castro Pérez; Amaelis Arada Rodríguez; Sanabria Negri?n, Jose? G.; Antonio Paz Cordobés

2008-01-01

313

Pleurésie massive après chirurgie du cancer de sein et arrêt précoce du Tamoxifène: à propos d’‘une observation  

Science.gov (United States)

Nous rapportons un cas de pleurésie massive droite probablement métastasique accompagnée d'un lymphœdème du membre supérieur droit ayant fait suite à une mastectomie et curage ganglionnaire indiqués pour un carcinome lobulaire du sein droit, associée à un arrêt précoce de la prise de Tamoxifène, vécu à Lubumbashi. PMID:25374634

Ngombe, Léon Kabamba; Kangulu, Ignace Bwana; Nday, Chantal Mwenze; Tshanda, Migrette Ngalula; Ngoy Lumbule, John; Matanga, Pierre Mbayo; Sampatwa, Olivier Ngoy; Nzaji, Michel Kabamba

2014-01-01

314

Pleurésie massive après chirurgie du cancer de sein et arrêt précoce du Tamoxifène: à propos d’‘une observation  

OpenAIRE

Nous rapportons un cas de pleurésie massive droite probablement métastasique accompagnée d'un lymphœdème du membre supérieur droit ayant fait suite à une mastectomie et curage ganglionnaire indiqués pour un carcinome lobulaire du sein droit, associée à un arrêt précoce de la prise de Tamoxifène, vécu à Lubumbashi.

Ngombe, Le?on Kabamba; Kangulu, Ignace Bwana; Nday, Chantal Mwenze; Tshanda, Migrette Ngalula; Ngoy Lumbule, John; Matanga, Pierre Mbayo; Sampatwa, Olivier Ngoy; Nzaji, Michel Kabamba

2014-01-01

315

Radio response of the lung after treatment of the mammary carcinoma with telecaesium - correlation with the dose-time relationship. Die Strahlenreaktion der Lunge nach Behandlung des Mammakarzinoms mit Telecaesium - Zusammenhang mit der Dosis-Zeit-Beziehung  

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51 mamma carcinom patients underwent postoperative telecaesium irradiation (50 Gy). Chest radiograms were taken preceding the treatment and following it by eight to ten weeks. By reason of the results it can be supposed, that the unavoidable lung reaction due to radiotherapy can be decreased and partly avoided by adequate fractionation. (orig.).

Baumgartner, E.; Weisz, C.; Mester, A. (Semmelweis Orvostudomanyi Egyetem, Budapest (Hungary). Radiologiai Klinika Emil Weil Hospital, Budapest (Hungary). Oncoradiological Center)

1990-12-01

316

Dual induction of caspase 3- and transglutaminase-dependent apoptosis by acyclic retinoid in hepatocellular carcinoma cells  

OpenAIRE

Abstract Background Hepatocellular carcinoma has a high mortality rate due to its rate of recurrence. Acyclic retinoid prevents recurrence of hepatocellular carcinoma in patients after surgical removal of their primary tumors by inducing apoptosis in hepatocellular carcinoma cells, although the molecular mechanisms of action are not understood. Methods Human hepatocellular carcinoma cells in culture, as well as nude mice transplanted with hepatocellular carcinom...

Moriwaki Hisataka; Okuno Masataka; Watanabe Makiko; Ishibashi Naoto; Fukaya Yayoi; Sano Tetsuro; Tatsukawa Hideki; Kojima Soichi

2011-01-01

317

Tonsillectomy and Adenoidectomy  

Medline Plus

Full Text Available ... adenoids are located behind the soft palate. The soft palate is the back, muscular part of the roof of the mouth. The adenoids are also part of the immune system and help fight infections. The uvula is also ...

318

Laryngeal adenoidcystic carcinoma  

Directory of Open Access Journals (Sweden)

Full Text Available A 72 year old male patient was admitted with complaints of dyspnoeaa of two months? duration. On local examination of ?he larynx, a polypoidal growth was seen in the sub glottis. Biopsy report was adenoid cystic carcinoma. Total laryngectomy was carried out. Post-operative course was uneventful. Occurrence of adenoid cystic carcinoma in the region of sub glottis is rare.

Mankodi R

1979-01-01

319

Survival over ten years after chemotherapy by paclitaxel and carboplatin, followed by a concomitant chemo-radiotherapy in nasopharyngeal undifferentiated carcinomas; Survie a dix ans apres chimiotherapie par paclitaxel et carboplatine, suivie d'une chimioradiotherapie concomitante dans les carcinomes indifferencies du nasopharynx  

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Based on 28 patients suffering from a cavum carcinoma and having been treated by neo-adjuvant chemotherapy (with paclitaxel and carboplatin) followed by a concomitant chemo-radiotherapy and an adjuvant chemotherapy, the authors analyse the response over time and identify the main causes of death. They also conclude that randomized studies are necessary to better asses the treatment efficiency. Short communication

Djekkoun, R.; Ferdi, N.; Bouzid, K. [CHU de Constantine, Constantine (Algeria)

2011-10-15

320

First chemotherapy by docetaxel, cisplatin and 5-fluoro-uracil (T.P.F.) followed by concomitant chemoradiotherapy in the treatment of cavum locally evolved undifferentiated carcinomas without metastases; Chimiotherapie premiere par docetaxel, cisplatine et 5-fluoro-uracile (TPF) suivie de chimioradiotherapie concomitante dans le traitement des carcinomes indifferencies localement evolues non metastatiques du cavum  

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It is a prospective study in order to evaluate the feasibility and the toxicity of a chemotherapy by docetaxel, cisplatin and 5-fluoro-uracil followed by a concomitant chemoradiotherapy in the treatment of non metastatic locally evolved undifferentiated carcinomas of the cavum. The conclusion was despite the low number of patients in our series, the observed results show that this neoadjuvant chemotherapy followed by a concomitant chemoradiotherapy in the locally evolved undifferentiated carcinomas of the cavum is feasible. however, the high acute toxicity needs the use of conformal irradiation techniques. Besides, a longer follow up is necessary to evaluate the therapy efficiency and the delayed toxicity of this protocol. (N.C.)

Sahli, B.; Bali, M.S.; Miles, I.; Djemaa, A. [CHU Benbadis, Constantine (Algeria)

2009-10-15

321

Concurrent split-course chemotherapy and radiotherapy for unresectable stage 3 non-small cell lung cancer: results of a preliminary phase 2 study; Chimioradiotherapie en split course dans les carcinomes bronchiques non a petites cellules de stade 3: resultats preliminaires d'une etude de phase 2  

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Purpose: we initiated at Hospital de Mulhouse a prospective phase II study to assess a split-course concurrent radio-chemotherapy in locally advanced non-small cell lung cancer. Materials and methods: from March 1996 to December 1997, 28 patients were included in our study. All patients had a stage III cancer. The chemotherapy scheduled included vinorelbine (20 mg/m{sup 2}/d, d1 and d5), cisplatin (20 mg/m{sup 2}/d, from d1 to d5), and 5-Fluorouracil (350 mg/m{sup 2}/d, from d1 to d5 by continuous infusion). The planned irradiation dose was 12.5 Gy per week with one daily fraction of 2.5 Gy from d1 to d5. Cycles were repeated every four weeks, for four cycles (50 Gy). Patients with a partial or complete response were proposed a fifth cycle. Results: of the 28 patients of the study, only 27 were analysed; one patient had a metastatic disease at diagnosis. Major hematologic toxicity occurred in 26% of the patients. One to five cycles of chemoradiotherapy were administrated per patient (median: four). Four patients had received fewer than three cycles and their responses were not assessable. Of the 23 patients assessed, 12 responses (52%) were observed, three CR (13%) and nine PR (39%). Median follow-up was 14 months, and median survival 13.5 months. One- and two-year survival rates were respectively 63%, and 14%. Local control rates was 11%, and 44% of the patients had a metastatic evolution. Conclusion: very preliminary results of this phase II study are disappointing, and quite inferior to the published results using chemoradiotherapy with conventional or hyperfractionated radiotherapy. Hematologic toxicity is restrictive. This type of chemoradiotherapy cannot be recommended. (author)

Benchalal, M.; Elgard Maitre, A.M.; Pignol, J.P.; Noirclerc, M.; Prevot, G. [Service d' oncoradiotherapie de Mulhouse, 68 (France); Bourderont, D. [Hopital du Hasenrain, 68 - Mulhouse (France); Salze, P. [Hopital Pasteur, 68 - Colmar (France); Bombaron, P.; Neidhardt, A.C.; Sizaret, O.; Newinger, G.; Zipper, J.M. [Centre Hospitalier de Mulhouse, 68 (France); Lambert, J.; Baumann, J.; Sabountchi, M. [Centre Medical Lalance, 68 - Lutterbach (France)

1999-12-01

322

Radioinduced pulmonary fibrosis: prospective study of clinical, dosimetric and biological predictive factors after conformal irradiation of non at small cells bronchi carcinomas; Fibroses radiques pulmonaires: etude prospective des facteurs predictifs cliniques, dosimetriques et biologiques apres irradiation conformationnelle des carcinomes bronchiques non a petites cellules  

Energy Technology Data Exchange (ETDEWEB)

This broad prospective study confirms the contribution of dosimetry factors ( pulmonary average dose, V10 to V50) in the predictive part for the delayed radioinduced fibrosis. Contrary to the acute radioinduced pneumopathy, no significant relationship has been underlined between the variations of cytokines and the delayed radioinduced fibrosis risk. (N.C.)

Claude, L.; Ginestet, C.; Martel-Lafay, I.; Carrie, C. [Centre Leon-Berard, 69 - Lyon (France); Etienne-Mastroiani, B. [Hopital Louis-Pradel, 69 - Lyon (France); Arpin, D. [Hopital de la Croix-Rousse, 69 - Lyon (France); Vincent, M. [Hopital Saint-Luc-Saint-Joseph, 69 - Lyon (France); Falchero, L. [Hopital de Villefranche, 69 - Villefranche s/Saone (France); Blay, J.Y. [Hopital Edouard-Herriot, 69 - Lyon (France); Perol, D. [Centre Leon-Berard, 69 - Lyon (France)

2007-11-15

323

Concomitant chemoradiotherapy with folfox-cetuximab in stage III oesophagus and cardia carcinomas: final results of the phase-II Erafox study of the Gercor group; Chimioradiotherapie concomitante par folfox-cetuximab dans les carcinomes du cardia et de l'oesophage de stade III: resultats definitifs de l'etude de phase II Erafox du groupe Gercor  

Energy Technology Data Exchange (ETDEWEB)

The authors report and discuss the results of a French national multicentre study which aimed at assessing the efficiency and tolerance of a folfox- and cetuximab-based chemotherapy concomitant with a radiotherapy for the treatment of stage-III cardia and oesophagus cancers. Patients (60 men and 19 women) have been selected according to the carcinoma type, performance index, age, weight loss over the last six months. Results are discussed in terms of response, steadiness, advancement, grade 3 and 4 toxicity, and side effects. The therapeutic efficiency corresponds to an objective response rate of 77 per cent, and tolerance profile seems to be acceptable for patients suffering from locally advanced cardia and oesophagus cancer. Short communication

Lledo, G.; Mammar, V.; Michel, P. [Hopital Jean-Mermoz, Lyon (France); Dahan, L. [CHU Rouen, Rouen (France); Mineur, L.; Dupuis, O. [Institut Sainte-Catherine, 84000 Avignon (France); Galais, M.P. [CHU Timone, Marseille (France); Chibaudel, B. [InstitutJean-Godinot, Reims (France); Jovenin, N. [Gercor, Paris (France); Gramont, A. de [Hopital Saint-Antoine, Paris (France)

2011-10-15

324

Operable bulky stages IB and 2 squamous-cell carcinomas of uterine cervix treated with combined primary radiation therapy and surgery; Carcinomes epidermoides du col uterin operables de stades IB et 2 de gros volume traites par irradiation premiere et chirurgie  

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Operable bulky stages IB and II squamous-cell carcinomas of uterine cervix treated with combined primary radiation therapy and surgery. Purpose. - To identify prognostic factors and treatment toxicity in a series of operable bulky stages I and II cervical carcinomas treated with a therapeutic modality combining primary irradiation and surgery. Patients and methods. - Between July 1982 and May 1996, 66 patients with bulky squamous-cell cervical carcinomas (stages IB2, IIA, and IIB with 1/3 proximal parametrial invasion) underwent primary external beam pelvic radiation therapy (37.40 Gy to 40 Gy over 4.5 weeks) and low-dose. (author)

Bernard, A.; Touboul, E.; Deniaud-Alexandre, E. [Hopital Tenon, Oncologie-Radiotherapie, 75 - Paris (France); Lefranc, J.P.; Blondon, J. [Groupe Hospitalier la Pitie-Salpetriere, Chirurgie Gynecologique, 75 - Paris (France); Genestie, C. [Groupe Hospitalier la Pitie-Salpetriere, Anatamopathologie, 75 - Paris (France); Uzan, S. [Hopital Tenon, Gynecologie Obstetrique, 75 - Paris (France)

2002-04-01

325

Conformal radiotherapy with intensity modulation of epidermoid of upper aero-digestive tracts carcinomas: prospective study 2003-2004 of the head and neck radiotherapy oncology group; Radiotherapie conformationnelle avec modulation d'intensite des carcinomes epidermoides des voies aerodigestives superieures: etude prospective 2003-2004 du groupe d'oncologie radiotherapie tete et cou (Gortec)  

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The conformal radiotherapy with intensity modulation is a validated technique that allows to reduce the toxicity in keeping satisfying rates of local control and survival. The threshold average dose of 34 Gy to the parotid seems reduce the rate of xerostomia with a grade over or equal to 2 to 12 and 24 months. (N.C.)

Toledano, I.; Lapeyre, M. [Centre Jean-Perrin, 63 - Clermont-Ferrand (France)

2009-10-15

326

Epidermoid carcinomas of the anal channel treated by concomitant association of radiotherapy and chemotherapy by 5-fluorouracil and cisplatin. Evaluation of functional results; Carcinomes epidermoides du canal anal traites par association concomitante de radiotherapie et de chimiotherapie par 5-fluorouracile et cisplatine. Evaluation des resultats fonctionnels  

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The good results got after chemoradiotherapy are confirmed. The quality of tumoral response after the first series of irradiation is probably the most powerful factor of independent prediction of survival in complete remission. (N.C.)

Deniaud-Alexandre, E.; Touboul, E.; Huguet, F.; Pene, F.; Schlienger, M. [Hopital Tenon, APHP, Service d' Oncologie-Radiotherapie, 75 - Paris (France); Tiret, E.; Parc, R. [Hopital Saint-Antoine, APHP, Service de Chirurgie Digestive, 75 - Paris (France); Sezeur, A. [Groupe Hospitalier de la Pitie-Salpetriere, APHP, Service de Chirurgie Digestive, 75 - Paris (France); Hannoun, L. [Groupe Hospitalier Diaconesses Croix-Saint-Simon, Service de Chirurgie Digestive, 75 - Paris (France); Houry, S. [Hopital Tenon, APHP, Service de Chirurgie Digestive, 75 - Paris (France)

2006-11-15

327

Intensity Modulated Radiation Therapy in Head and Neck Squamous Cell Carcinoma: state of the art and future challenges; La Radiotherapie par modulation d'intensite dans les carcinomes epidermoides de la sphere cervico-maxillo-faciale: etat de la question et defis futurs  

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Intensity-modulated radiation therapy (IMRT) for head and neck (HN) tumors refers to a new approach to the whole treatment procedure from patient immobilization to beam delivery. Implementation of IMRT thus requires knowledge of setup uncertainties, adequate selection and delineation of target volumes based on clinical examination and optimal imaging modalities, appropriate specification and dose prescription regarding dose-volume constraints, and ad hoc quality control of both the clinical and physical aspects of the whole procedure. A large number of issues still need to be resolved and/or further refined, such as the optimal selection and delineation of the target volume in particular, with the introduction of functional imaging, and a better integration of improved dose distribution into the fractionation strategy. IMRT is associated with a potentially increased incidence of carcinogenesis, although in the HN area this risk is relative to the intrinsic risk of co-morbidity and secondary cancer associated with the patient's lifestyle. Currently, the implementation of IMRT into routine clinical practice for HN cancers may not be a straightforward matter, and should probably be restricted to selected patients and selected institutions with adequate resources and experience. This review emphasizes the above aspects and provides some recommendations for the future use of IMRT in patients with HN tumors. (author)

Gregoire, V. [Universite Catholique de Louvain, a Radiation Oncology Dept. and Lab. of Radiobiology, St-Luc University Hospital, Brussels (Belgium); Maingon, P. [Centre Georges-Francois Leclerc, Radiation Oncology Dept., 21 - Dijon (France)

2005-02-15

328

{sup 18}FDG and external radiotherapy. The point of view of the radiotherapist.; application of the techniques of fusion imaging to radiotherapy of non-small-cell lung carcinoma; {sup 18}FDG et radiotherapie externe, le point de vue du radiotherapeute.: application des techniques de fusion d'images a la radiotherapie des carcinomes bronchiques  

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The prognosis of patients with localized non-small-cell lung carcinoma and treated with radiation therapy remains poor. The three-dimensional conformational radiotherapy aims to increase the dose of radiation at the tumor volume to increase the local control, while sparing the healthy tissue neighborhood. The reduction of the safety margins and the irradiated volumes obliges to determine with most acute precision the exact tumor volume. However, the scanner alone is insufficient, particularly at the mediastinal level and at a distance. The positron emission tomography allows distinguishing a biological tumor volume. It helps to define the lung tumor volume, especially when the tumor is accompanied by atelectasis, and to recover the lymph node staging at the mediastinal level and at a distance. Even if the sensibility and the specificity are not 100 %, positron emission tomography now becomes essential before considering an escalation of thoracic radiation dose.

Deniaud-Alexandre, E. [Centre Hospitalier de la Cote-Basque, Service d' Oncologie, 64 - Bayonne (France)

2008-10-15

329

Conservative treatment of epidermoid carcinomas of the anal duct by external irradiation followed by low dose rate brachytherapy by iridium 192; Traitement conservateur des carcinomes epidermoides du canal anal par irradiation externe suivie de curietherapie de bas debit de dose par Iridium 192  

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The association of external radiotherapy and brachytherapy is an efficient loco regional treatment of epidermoid carcinomas of the anal duct with an acceptable delayed toxicity rate and a high rate of the sphincter function conservation. (N.C.)

Minsat, M.; Moureau-Zabotto, L.; Giovannini, M.; Lelong, B.; Viret, F.; Bories, E.; Tallet, A.; Salem, N. [Institut Paoli-Calmettes, 13 - Marseille (France)

2007-11-15

330

Mediastinal radiotherapy after multidrug chemotherapy and prophylactic cranial irradiation in patients with SCLC - treatment results after long-term follow-up and literature overview; Radiotherapie mediastinale apres chimiotherapie et irradiation prophylactique de l'encephale chez des patients atteints d'un carcinome bronchique a petites cellules - Resultats et revue de la litterature  

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Introduction. - Curative therapy for patients with small-cell lung cancer (SCLC) is based on multidrug chemotherapy combinations and radiotherapy. After a long time follow-up, the aim of the study was to evaluate the efficacy and toxicity of sequential chemo-radiotherapy and the effect of prophylactic cranial irradiation (PCI). Methods. - From 1995-2005, 96 patients with SCLC (64 limited-disease [LD], 32 extensive-disease [ED]; median age 61 years [range 39-79]) were treated at our department with varying chemotherapy regimens and sequential mediastinal radiotherapy (50 Gy + 10 Gy boost in case of residual disease after chemotherapy). Afterwards, 15 patients with LD, good general condition and at least partial response after local treatment received PCI (30 Gy). Results. - After a median follow-up of 78.6 months, 20 patients remained alive (20.8%, median survival time 18.2 months). The 2-/5-year overall survival rates were 33.8% and 12.6%, the 2-/5-year loco-regional control rates were 30.3% and 24.5%, respectively. Distant metastases occurred in 43 patients (24 cerebral). Cerebral metastasis occurred in 6.7% and 27.2% of the patients with PCI and without PCI respectively. Only tumor stage showed a statistically significant impact on overall survival and loco-regional control in multivariate analysis. Radiotherapy was well tolerated. Grade 3/4 toxicity occurred in seven patients. Prognosis of patients with SCLC remains poor. Administration of PCI in selected patients bears a decrease in the incidence of cerebral metastases. Alternative chemotherapy schemes as well as irradiation schemes and techniques should be the substance of future randomized trials. (authors)

Herrmann, M.K.A.; Bloch, E.; Overbeck, T.; Wolff, H.A.; Hille, A.; Hess, C.F.; Christiansen, H. [Department of Radiotherapy, University Hospital Goettingen, Robert-Koch-Str. 40, 37075 Goettingen (Germany); Koerber, W. [Department of Pneumology, Weende Hospital, Section Lenglern, Pappelweg 5, 37120 Bovenden-Lenglern (Germany); Vorwerk, H. [Department of Hematology and Oncology, University Hospital Goettingen, Robert-Koch-Str. 40, 37075 Goettingen (Germany); Muller, M.; Pradier, O. [Department de cancerologie, CHU Morvan, 5, avenue Foch, 29200 Brest cedex (France)

2011-04-15

331

Combination of radiotherapy and cetuximab for patients suffering from of an advanced and non operable epidermoid carcinoma of the ORL sphere: results and side effects; Association de radiotherapie et de cetuximab chez des patients atteints d'un carcinome epidermoide de la sphere ORL evolue non operable: resultats et effets secondaires  

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The authors report a retrospective survey of a set of locally advanced epidermoid carcinomas treated by irradiation and cetuximab. They assessed the response to the treatment, the specific survival, and the global survival as well as the tolerance. The survey is based on 31 men and 5 women suffering from different stage 4 non-metastatic advanced epidermoid carcinomas of the ORL sphere. Short communication

Acevedo, C.; Valette, G.; Bouchekoua, M.; Marianowski, R.; Pradier, O. [CHU Morvan, 29 - Brest (France)

2010-10-15

332

Feasibility of an early dynamic acquisition in PET-F.D.G. to evaluate the prognosis of epidermoid carcinomas of superior aero digestive pathways; Faisabilite d'une acquisition dynamique precoce en TEP-FDG pour l'evaluation pronostique des carcinomes epidermoides des VADS  

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purpose: evaluate the feasibility of an early dynamic acquisition in PET-F.D.G. in the staging of squamous cell carcinomas of upper aero digestive tract. Extract kinetics parameters of F.D.G. tumor uptake and compare them to SUV{sub max} at 60 minutes (prognosis value recognized but without established cut-off) and to {Delta}SUV{sub max} (1-2 h). Conclusions: The results of our study demonstrates the realisation feasibility of a early 60 minutes dynamic acquisition in PET-F.D.G. at the cervical level, allowing to get a kinetic parameter (initial slope) independent of the SUV{sub max} simple measure at 1 h and to envisage to compare their respective prognosis value in the initial evaluation of epidermoid carcinomas of superior aero digestive pathways. (N.C.)

Abgral, R.; Le Roux, P.Y.; Querellou, S.; Turzo, A.; Salaun, P.Y. [CHU de Brest, Service de medecine nucleaire, 29 (France); Valette, G.; Potard, G.; Marianowski, R. [CHU de Brest, Service d' oto-rhinolaryngologie, 29 (France); Conan-Charlet, V. [CHU de Brest, Service d' anatomopathologie, 29 (France); Moser, E. [Centre hospitalier de Quimper, service de radiotherapie, 29 (France)

2010-07-01

333

Thyroid medullary carcinoma and PET/CT with {sup 18}F-DOPA in the post surgery follow up: preliminary results; Carcinome medullaire de la thyroide et TEP/TDM a la {sup 18}F-DOPA dans le suivi post-chirurgical: resultats preliminaires  

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Purpose: to study the contribution of the PET/CT with {sup 18}F DOPA in the therapy follow-up of patients with a history of medullary thyroid carcinoma and biological suspicion of residual disease or recurrence. Conclusions: The preliminary results show the interest of the PET/CT with {sup 18}F DOPA in the therapy follow-up and the management of patients suffering of medullary thyroid carcinoma in biological relapse. (N.C.)

Keomany, J.; Rust, E.; Constantinesco, A.; Imperiale, A. [CHU de Strasbourg, Service de biophysique et medecine nucleaire, 67 (France); Detour, J. [CHU de Strasbourg, Service de radiopharmacie, 67 (France); Chabrier, G.; Goichot, B. [CHU de Strasbourg, Service de medecine interne, endocrinologie et nutrition, 67 (France); Schneegans, O. [FNCLCC Paul-Strauss, 67 - Strasbourg (France)

2010-07-01

334

Metastatic calcifications of hyperparathyroidism detected by M.D.P.- Tc 99 m bone scintigraphy in patients with parathyroid carcinoma: A case report; Les calcifications metastatiques de l'hyperparathyroidie identifiees par scintigraphie osseuse au M.D.P.-Tc 99 m dans le cadre du carcinome parathyroidien: a propos d'un cas  

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The authors report a case of gastric, renal, pulmonary, and myocardial uptake of M.D.P.-Tc 99 m in a patient with parathyroid carcinoma. Parathyroid carcinoma is a rare cause of primary hyperparathyroidism which becomes complicated during its evolution by metastatic calcifications. Metastatic calcifications are frequently located in lungs and heart. If an adequate treatment is not undertaken, these calcifications progress and evolve into severe respiratory and cardiac complications. In our patient, quasi-complete disappearance of metastatic calcifications on the follow-up bone scintigraphy, performed four weeks after surgical cure of parathyroid tumour, indicates the great interest of this examination in early identification of metastatic calcifications and monitoring of their disappearance after treatment. (authors)

Doudouh, A.; Biyi, A.; Oufroukhi, Y.; Zekri, A. [Hopital Militaire Mohammed-5, Service de Medecine Nucleaire, Rabat (Morocco); Sekkach, Y. [Hopital Militaire Mohammed-5, Service de Medecine B, Rabat (Morocco)

2008-02-15

335

Check-up and follow-up of papillary and follicular thyroid carcinoma in the department of nuclear medicine at Ibn Sina hospital Rabat; Bilan et surveillance des carcinomes papillaire et vesiculaire de la thyroide dans le service de medecine nucleaire de l'hopital Ibn Sina de Rabat  

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In the department of nuclear medicine at Ibn Sina university hospital. Thyroid carcinoma follow-up strategy has been modified and includes cervical ultrasonography and thyroglobulin measurement. The role of radio-iodine scanning in the management of differentiated thyroid carcinoma is decreasing. Papillary and follicular carcinoma have good prognosis but late metastases exist and can lead to death. A lifelong follow-up is therefore mandatory. The main goal of follow-up is to detect earlier persistent or recurrent disease. (authors)

Ben Rais Aouad, N.; Ghfir, I.; Guerrouj, H.; Fellah, S.; Rahali, J.; Ksyar, R.; Missoum, F.; Bssis, A.; Azrak, S. [CHU Ibn Sina, Service de Medecine Nucleaire, Rabat (Morocco)

2009-10-15

336

Study of the correlation between immunohistochemistry of the initial tumor and PET/CT after recombining TSH (RHTSH) in case of tumor recurrence in differentiated thyroid carcinomas; Etude de la correlation entre l'immunohistochimie de la tumeur initiale et la TEP-FDG/TDM apres TSH recombinante (RHTSH) en cas de recidive tumorale dans les carcinomes thyroidiens differencies  

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Purpose: In patients with differentiated thyroid carcinoma, the correlation between the value of thyroglobulin and the positivity of F.D.G.-PET remains controversial. We looked at whether the immunohistochemical criteria of the original tumor could be predictive of a positive PET in cases of tumor recurrence. Conclusions: on a larger series, we have not confirmed the results of Hooft (JCEM 2005). This study did not reveal immunohistochemical marker, present in the original tumor, which would be predictive of a positive PET-F.D.G. in the search for a recurrence. The study of NIS and GLUT1 expression is underway. (N.C.)

Lansoy-Kuhn, C.; Mechken, F.; Edet-Sanson, A.; Vera, P. [Centre Becquerel and QuantIF LITIS EA4108, Service de medecine nucleaire, 76 - Rouen (France); D' anjou, J.; Cornic, M. [Centre Henri-Becquerel, service anatomopathologie, 76 - Rouen (France)

2010-07-01

337

Comparison of the results obtained with two thyroglobulin (Tg) dosage kits in patients afflicted with differentiated thyroid carcinoma. Consequences for practice; Comparaison des resultats obtenus avec deux trousses de dosage de la thyroglobuline (Tg) chez les patients atteints de carcinome differencie de la thyroide. Consequences pour la pratique  

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We have compared the results obtained with two thyroglobulin dosage kits after thyroidectomy for thyroid differentiated carcinoma: T1 = ELSA-HTG, CIS bio international (detection threshold: 0.5 ng/mL) and T2 = Tg IRMA, ERIA Diagnostics Pasteur (detection threshold = 0.2 ng/mL). T2 has been utilized in 2 populations presenting an undetectable Tg by T1 (< 0.5 ng/mL) in spite of presence of {sup 131}I cervical fixations: either in anti-Tg Ac absence (population P1, 102 cases) or in their presence (population P2, 16 cases). T2 has been utilized in a third population presenting Tg rates detectable by T1 (P3, 37 cases, Tg from 0.5 to 37.7 ng/mL). The dosages were performed under simulation by endogenous TSH. The following results were obtained by T2: Tg > 0.2 ng/mL 61 times of 106 (P1) and 6 times of 16 (P2), Tg > 0.2 ng/mL 45 times of 106 (P1) and 5 times of 16 (P2). For P3, Tg with T2 is always higher than Tg by T1 (average value in ng/mL, [range]: 11.2 [1.8-71] for T2 vs 4.6 [0.5-37.7] for T1; p = 0.0001), correlation coefficient (r = 0.96) and regression straight (Tg T2 = Tg T1 x 1.84 + 3.55; p = 0.0001) showing a strong correlation between T1 and T2. A Tg rate detectable or increasing by the kit T2 vs a reference obtained with kit T1 should be interpreted cautiously. The linear relation described above is applicable to values detectable and lower than 40 ng/mL by T1. For the other values (undetectable or higher than 40 ng/mL, by T1) and in case of doubt, a re-dosage of the anterior serums on tubes in serothec is necessary

Muratet, J.P.; Minier, J.F.; Daver, A.; Larra, F. [Centre Paul Papin, 2, rue Moll, Angers cedex 01 (France)

1997-12-31

338

Statistical study of a series of 672 carcinomas of the cervix: results and complications according to age and modalities of treatment; Etude statistique d`une serie de 672 carcinomes du col uterin. Resultats et complications selon l`age et les modalites de traitement  

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The study on 672 infiltrating carcinomas of the cervix treated from 1977 until the end of 1991, by a radiosurgical combination or by exclusive irradiation. The radiosurgical series includes stages 1 B and II and patients under 50 years because of the therapeutic protocol. Most of the patients over 50 years and all stages III were treated by exclusive irradiation. External beam irradiation was most often performed in 4 fields by linear accelerator of 12 and 25 MeV. Utero vaginal brachytherapy used the technique of molds. In 55 cases, a complementary interstitial brachytherapy was applied on residual node. A computer dosimetry was made for each patient with calculation of the doses delivered to organs at risk and to node areas . The results at 5 years are as follows for the total series: locoregional control (LRC) 79%, specific survival (SS) 73%, overall survival 70%. For stage I, the LRC of the radiosurgical series is 92%, that of the series of exclusive irradiation 87%. For stage II, the LRC is 70% in the radiosurgical series and 79% in the series of exclusive irradiation. Conversely, for distal stage II, the difference is very significant in favour of exclusive irradiation (LRC 31%/77%, SS 26%/70%). If we consider the results according to age, the difference for distal stage II comes mostly from patients under 50 years and especially those aged 40 years or under. For stage III, the LRC is 61% for patients over 50 years and 34% for those aged 50 years or under. As the nodes, the results of surgical pieces and lymphadenectomy are studied. The patients under 40 years in stages II and III present more metastases than others. Among the therapeutic factors, the dose rate and the treatment duration were particularly studied. A detailed study of the complications is made for the radiosurgical series as for the series of exclusive irradiation according to the French Italian glossary of complications as well as a study of the factors inducing them.

Pernot, M.; Hoffstetter, S.; Peiffert, D.; Carolus, J.M.; Guillemin, F.; Verhaeghe, J.L.; Marchal, C.; Luporsi, E.; Beckendorf, V.; Stines, J.; Aletti, P.; Dartois, D.; Lesur, A.; Bey, P. [Centre de Lutte Contre le Cancer, 54 - Nancy (France)

1995-12-31

339

Intra-arterial injection of lipid nano-capsules charged in rhenium-188, for the treatment of hepatocellular carcinomas among the rat; Injection intra-arterielle de nanocapsules lipidiques chargees en rhenium-188, pour le traitement des carcinomes hepatocellulaires chez le rat  

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The objective of this study was to evaluate the therapy efficiency of the {sup 188}Re incorporated in the middle of lipid capsules (N.C.L. {sup 188}Re-S.S.S.) on a hepato carcinoma model of rat. The preliminary results are encouraging and show the efficiency of a single injection of N.C.L.{sup 188}Re-S.S.S. in a hepato carcinoma model of rat. (N.C.)

Vanpouille, C.; Lacoeuille, F.; Hindre, F. [Inserm U646, Angers, (France); Roux, J. [service commun animalerie, hospitalo-universitaire, Angers, (France); Aube, C. [service de radiologie, CHU d' Angers, (France); Oberti, F. [service de gastro-enterologie et hepatologie, CHU d' Angers, (France); Lejeune, J.J.; Couturier, O. [service de medecine nucleaire, CHU d' Angers, (France)

2009-05-15

340

Target volumes in radiotherapy - head and neck tumors intensity - Modulated radiation therapy (IMRT) of nasopharyngeal carcinoma: practical aspects in the delineation of target volumes and organs at risk; Radiotherapie conformationnelle avec modulation d'intensite (RCMI) des carcinomes du cavum: aspects pratiques de la delineation des volumes cibles et des organes critiques  

Energy Technology Data Exchange (ETDEWEB)

The objective of this paper is to give some practical landmarks for the delineation of target volumes and organs at risk in Intensity Modulated Radiation Therapy for Nasopharyngeal Carcinoma. This delineation, drawn from anatomo-clinical data, natural history of the disease and radiological pre-treatment evaluation, seems to be easier to define than the delineation of other head and neck cancer localizations (oropharynx and oral cavity for example). Experience inside national and international cooperative groups should tend to standardize this initial and fundamental step of Nasopharyngeal Conformal Radiotherapy. (authors)

Marcy, P.Y.; Bensadoun, R.J. [Centre Antoine-Lacassagne, 06 - Nice (France); Zhu, Y. [Centre du cancer, Huangzhou (China)

2005-06-15

341

Total encephalic radiotherapy and concomitant administering of trastuzumab for brain metastases of a mammary carcinoma with HER2 overexpression: experience of the Curie Institute; Radiotherapie encephalique totale et administration concomitante de trastuzumab pour des metastases cerebrales d'un carcinome mammaire surexprimant HER2: experience de l'institut Curie  

Energy Technology Data Exchange (ETDEWEB)

The authors report a retrospective study of assessment of the tolerance to and of the activity of the trastuzumab in association with a total encephalic irradiation. The study is based on 31 patients suffering from brain metastases in relationship with a mammary cancer with HER2 expression, and who have been submitted to a total encephalic radiotherapy with a trastuzumab treatment. This medicine appears to be efficient and harmless. A clinic trial should confirm these results. Short communication

Chargari, C.; Idrissi, H.R.; Pierga, J.Y.; Bollet, M.; Dieras, V.; Campana, F.; Cottu, P.; Fourquet, A.; Kirova, Y. [Institut Curie, 75 - Paris (France)

2010-10-15

342

Concomitant bid radiotherapy with cisplatin and 5-fluorouracil in unresectable carcinoma of the pharynx: 10 year's experience at the Centre Antoine Lacassagne; Radiotherapie bifractionnee et chimiotherapie par cisplatine et 5-fluoro-uracile concomitantes dans les carcinomes epidermoides localement evolues non resecables du pharynx: dix ans d'experience au centre Antoine Lacassagne  

Energy Technology Data Exchange (ETDEWEB)

Patients suffering from locally advanced unresectable squamous cell carcinoma of the oropharynx and hypopharynx treated with radiotherapy alone have a poor prognosis. More than 70% of patients die within 5 years mainly due to local recurrences. The aim of this study was to evaluate retrospectively the Antoine Lacassagne Cancer Center's experience in a treatment by concomitant bid radiotherapy and chemotherapy. Evaluation was based on analysis of the toxicity, the response rates, the survival, and the clinical prognostic factors. From 1992 to 2000, 92 consecutive patients were treated in our single institution. All of them had stage IV, unresectable squamous cell carcinoma of the pharynx and they received continuous bid radiotherapy (two daily fractions of 1.2 Gy, 5 days a week, with a 6-h minimal internal between fractions). Total radiotherapy dose was 80.4 Gy on the oropharynx and 75.6 Gy on the hypopharynx. Two or three chemotherapy courses of cisplatin (CP)-5-fluorouracil (5FU) were given during radiotherapy at 21 -day intervals (third not delivered after the end of the radiotherapy). CP dose was 100 mg/m{sup 2} (day 1) and 5-FU was given as 6-day continuous infusion (750 mg/m{sup 2}/day at 1. course; 430 mg/m{sup 2}/day at 2. and 3. courses). Special attention was paid to supportive care, particularly in terms of enteral nutrition and mucositis prevention by low-level laser energy. Acute toxicity was marked and included WHO grade III/IV mucositis (89%, 16% of them being grade IV), WHO grade III dermatitis (72%) and grade III/IV neutropenia (61%). This toxicity was significant but manageable with optimised supportive care, and never led to interruption of treatment for more than 1 week, although there were two toxic deaths. Complete global response rate at 6 months was 74%. Overall global survival at 1 and 3 years was 72% and 50% respectively, with a median follow-up of 17 months. Prognostic factors for overall were the Karnofsky index (71% survival at 3 years for patients with a Karnofsky index of 90-100% versus 30% for patients with a Karnofsky index of 80% versus 0% for patients with a Karnofsky index of 60-70%, p = 0.0001) and tumor location (55% at years for oropharynx versus 37% for pan-pharynx versus 28% for hypopharynx, p=0.009). These results confirm the efficacy of concomitant bid radiotherapy and chemotherapy in advanced unresectable tumor of the pharynx. The improvement in results will essentially depend on our capacity to restore in a good nutritional status the patients before beginning this heavy treatment. (author)

Magne, N.; Pivot, X.; Marcy, P.Y.; Chauvel, P.; Courdi, A.; Dassonville, O.; Possonnet, G.; Vallicioni, J.; Ettore, F.; Falewee, M.N.; Milano, G.; Santini, J.; Lagrange, J.L.; Schneider, M.; Demard, F.; Bensadoun, R.J. [Centre Antoine-Lacassagne, 06 - Nice (France)

2001-08-01

343

Ulcere de Marjolin: complication redoutable des sequelles de brûlures  

Science.gov (United States)

Summary L’ulcère de Marjolin désigne la transformation maligne d’une cicatrice de brûlure ou de toute autre plaie ou ulcération chronique. Le type histologique prédominant reste le carcinome épidermoïde, et il est caractérisé par son agressivité locale, des métastases plus fréquentes, un risque de récurrence et une mortalité plus importante que les carcinomes épidermoïdes classiques. Notre travail est une étude rétrospective portant sur 21 cas d’ulcère de Marjolin, colligés au service de chirurgie plastique du CHU Mohammed VI de Marrakech, avec pour but de relever les aspects épidémiologiques, thérapeutiques et évolutifs de cette pathologie. L’amélioration du pronostic nécessite non seulement un diagnostic et un traitement précoce, mais surtout une attitude préventive qui consiste en des greffes cutanées précoces et des soins réguliers de toute cicatrice de brûlure. PMID:24799850

Ouahbi, S.; Droussi, H.; Boukind, S.; Dlimi, M.; Elatiqi, O.K.; Elamrani, M.D.; Benchamkha, Y.; Ettalbi, S.

2013-01-01

344

Perturbation de la voie de signalisation du TGF-? par les protéines du virus de l'hépatite C , impact sur la carcinogenèse  

OpenAIRE

L'infection chronique par le virus de l'hépatite C (VHC) conduit au développement de pathologies hépatiques, telles que la fibrose dont le terme évolutif est la cirrhose sur laquelle peut se développer un carcinome hépatocellulaire. Les observations cliniques indiquent que le VHC interfère avec la voie de signalisation du Transforming Growth Factor ? (TGF?). Entre autres fonctions, cette cytokine induit la transition épithélio-mésenchymateuse (EMT), ce qui favorise la migration ce...

Verga-gerard, Amandine

2012-01-01

345

Urinary Bladder Cancer: A Clinicopathological and Histological Study  

OpenAIRE

Bladder cancer is the one of the most common genito urinary tract malignancy and more than 90% of bladder cancer is of urothelial carcinomas that ranks fourth among cancers occurring in males. Although, over 50% of cases are diagnosed by biopsy at an early stage. The prognosis is sometimes difficult to assess because of heterogeneity, multifocality and tumor recurrence. In the present study, among 70 urinary bladder tumor patients, 61 (87%) were of Transitional Cell Carcinom...

Sathya, M.; Chinnaswamy, P.

2014-01-01

346

Dual Roles of Oct4 in the Maintenance of Mouse P19 Embryonal Carcinoma Cells: As Negative Regulator of Wnt/?-Catenin Signaling and Competence Provider for Brachyury Induction  

OpenAIRE

Transcription factor Oct4 is expressed in pluripotent cell lineages during mouse development, namely, in inner cell mass (ICM), primitive ectoderm, and primordial germ cells. Functional studies have revealed that Oct4 is essential for the maintenance of pluripotency in inner cell mass and for the survival of primordial germ cells. However, the function of Oct4 in the primitive ectoderm has not been fully explored. In this study, we investigated the role of Oct4 in mouse P19 embryonal carcinom...

Marikawa, Yusuke; Tamashiro, Dana Ann A.; Fujita, Toko C.; Alarcon, Vernadeth B.

2010-01-01

347

Etude fonctionnelle de l'Ubinucléine, partenaire cellulaire du facteur de transcription EB1 du virus d'Epstein-Barr et inhibition du cycle lytique viral  

OpenAIRE

Découvert en 1964, le virus d'Epstein-Barr appartient à la famille des gamma-herpèsvirus. Ce virus à ADN présente une forte prévalence (90% de la population adulte est infectée). Ce fut le premier virus identifié comme associé à des cancers (lymphome de Burkitt et d'Hodgkin, carcinome gastrique et de l'oropharynx). Ce virus a pour spécificité de posséder deux cycles distincts : latent et lytique (production de particules virales). Le facteur de transcription viral EB1 (ou Zebra) ...

Conti, Audrey

2012-01-01

348

Epstein-Barr Virus (EBV)-associated Gastric Carcinoma  

OpenAIRE

The ubiquitous Epstein-Barr virus (EBV) is associated with several human tumors, which include lymphoid and epithelial malignancies. It is known that EBV persistently infects the memory B cell pool of healthy individuals by activating growth and survival signaling pathways that can contribute to B cell lymphomagenesis.  Although the monoclonal proliferation of EBV-infected cells can be observed in epithelial tumors, such as nasopharyngeal carcinoma and EBV-associated gastric carcinom...

Hironori Yoshiyama; Masahisa Jinushi; Jun Nishikawa; Asuka Nanbo; Hisashi Iizasa

2012-01-01

349

La tumeur de Buschke-Lowenstein anorectale: à propos de 16 cas et revue de la littérature  

OpenAIRE

La tumeur de Buschke-Lowenstein est une affection rare appartenant au groupe des carcinomes verruqueux. Elle survient le plus souvent chez des sujets pubères en pleine activité sexuelle. Une infection par human papillomavirus (HPV) 6 et 11 est volontiers associée à ces tumeurs. Elle se caractérise par la fréquence des récidives et le risque de transformation maligne. Son traitement est difficile même si l'histologie confirme la bénignité. A partir de 16 observations de TBL et d'une ...

Njoumi, Noureddine; Tarchouli, Mohamed; Ratbi, Moulay Brahim; Elochi, Mohamed Reda; Yamoul, Rajae; Hachi, Hafid; Bougtab, Abdesslam

2013-01-01

350

Tumeur neuroendocrine mammaire primitive: à propos d'un cas rare  

OpenAIRE

Les carcinomes neuroendocrine primitifs du sein sont des tumeurs rares et représentent 2 à 5% des cancers mammaires. Nous rapportons le cas de localisation mammaire chez une patiente de 50 ans. Il s'agit d'une tumeur classée T4d N1 M0. La tumeur est suspecte radiologiquement. Une microbiopsie est réalisée. L’étude anatomopathologique et immunohistochimique est en faveur d'une tumeur neuroendocrine primitive du sein à grande cellules exprimant les récepteurs progestéroniques seuleme...

Laabadi, Kamilia; Jayi, Sofia; El Houari, Aziza; Tawfic, Harmouch; Bouguern, Hakima; Chaara, Hikmat; Melhouf, Abdilah; Amarti, Afaf

2013-01-01

351

Porocarcinome sudoral eccrine de la face: tumeur annexielle rare  

OpenAIRE

Le porocarcinome sudoral eccrine est une tumeur cutanée maligne à point de départ glande sudorale. Un homme de 48 ans s'est présenté à la consultation avec une lésion simulant un carcinome basocellulaire de la tempe droite. La biopsie de cette lésion a révélé un porocarcinome eccrine. Le siège facial de cette tumeur est très rare. Elle pose un problème diagnostique et thérapeutique. Nous discutons les différents aspects de cette tumeur avec revue de la littérature.

Lakouichmi, Mohammed; El Bouihi, Mohamed; Zrara, Ibtissam; Lahmiti, Saad; Hattab, Nadia Mansouri

2013-01-01

352

Enolase isozymes in renal tubules and renal cell carcinoma.  

OpenAIRE

To elucidate the localization of enolase isozymes in renal tubules and renal cell carcinoma, an immunohistochemical study and quantitative analysis by employing the enzyme immunoassay were performed. The alpha-enolase was localized in almost all epithelial cells of renal tubules except for loops of Henle. The gamma-enolase was localized in macula densa cells and epithelial cells of loops of Henle and collecting ducts of the medulla, but not in those of proximal tubules. In renal cell carcinom...

Haimoto, H.; Takashi, M.; Koshikawa, T.; Asai, J.; Kato, K.

1986-01-01

353

Potentialisation de la virothérapie anti-tumorale basée sur des adénovirus oncolytiques dans le traitement des cancers côliques et rénaux  

OpenAIRE

Nous avons mis en place au cours de ce travail de thèse différentes stratégies permettant d'améliorer l'efficacité thérapeutique des adénovirus (Ad) oncolytiques contre différents types de tumeurs. Une première stratégie a été de combiner un inhibiteur d'histone-désacétylase, l'acide valproique (VPA) avec un Ad oncolytique à capside sauvage E1?24 (CRAd) dans le traitement de carcinomes côliques. Nous avons dans un premier temps démontré que la combinaison du CRAd et du VPA ...

Bressy, Christian

2013-01-01

354

Contribution à l'étude des tumeurs de la tête et du cou : analyse critique de certaines voies d'abord chirurgicales des espaces rétro et latéro-pharyngés et des facteurs pronostiques des lymphomes malins non-hodgkiniens de la tête et du cou  

OpenAIRE

Les espaces rétro et latéro-pharyngés sont le siège de tumeurs de nature histologique très variée. Leur richesse en éléments lymphatiques les rend particulièrement exposés aux disséminations lymphatiques des carcinomes épidermoïdes mais aussi aux localisations primitives et secondaires des lymphomes malins de la tête et du cou. Leur abord à visée diagnostique ou thérapeutique reste délicat. La première partie de ce travail a permis de préciser la technique, les limites et ...

Laccourreye, Laurent

2008-01-01

355

Pathologies thyroïdiennes et modèles in vitro :profils d'expression génique et phénotypes moléculaires  

OpenAIRE

La thèse s’inscrit dans un projet de recherche global visant à caractériser les tumeurs thyroïdiennes sur le plan moléculaire, afin de mieux comprendre leur physiopathologie et afin d’identifier des biomarqueurs (signatures moléculaires) qui pourront être utilisés pour le diagnostic, le pronostic et leur traitement. Parmi celles-ci, nous distinguons les adénomes autonomes (AA) et folliculaires (FTA) tumeurs bénignes encapsulées, et les carcinomes, tumeurs malignes. Ceux-ci sont...

He?brant, Aline

2010-01-01

356

Utilisation d'un anticorps monoclonal anti-Tn en immunothérapie des cancers  

OpenAIRE

La transformation des cellules normales de l'organisme en un phénotype malin est souvent accompagnée de changements dans leur antigénicité. L'antigène Tn (GalNac-O-Ser/Thréo) est un antigène (Ag) glycopeptidique spécifique des tumeurs et exprimé à la membrane plasmique des cellules cancéreuses dans la majorité des carcinomes humains ainsi que dans certaines tumeurs hématologiques, tandis qu'il n'est pas détecté dans les cellules normales. Il représente donc une cible potentiel...

Heitzmann-daverton, Ade?le

2013-01-01

357

PCNA Expression in Epithelial Ovarian Carcinomas  

OpenAIRE

Objective: Immunohistochemical detection of PCNA shows active DNA replication and DNA damage resulting in carcinogenesis as well. PCNA has been used successfully as a marker of proliferation in hematologic malignancies, gastrointestinal malignancies, breast, skin, lung and urinary tract malignancies. In this study, it was aimed to determine the possibility of using PCNA, which shows proliferation in colorectal and bladder carcinomas, as tumor proliferation index in epithelial ovarian carcinom...

Zengerog?lu, Sema; Abi?ke, Faruk

2010-01-01

358

Wavelength and light-dose dependence in tumour phototherapy with haematoporphyrin derivative.  

OpenAIRE

Red light (c. 630 nm) is almost universally used in tumour phototherapy as it is the most penetrating of the porphyrin excitation wavebands. However, measurements of tumour attenuation of light of different wavelengths and of the excitation spectrum of haematoporphyrin derivative in vitro suggested that green light might be more efficient than red in destroying thin tumours. Experimentally, we confirmed this for tumours up to approximately 1.2 mm thick, a depth exceeding that of most carcinom...

Gemert, J. C.; Berenbaum, M. C.; Gijsbers, G. H.

1985-01-01

359

Systemic amyloidosis and ovarian carcinoma.  

OpenAIRE

A case of ovarian carcinoma and systemic amyloidosis in a 64 year old woman with nephrotic syndrome is reported. Immunohistochemical study of renal and rectal biopsy specimens revealed the presence of amyloidosis AA antigens, consistent with secondary amyloidosis. The absence of chronic inflammatory or infectious disease suggested the presence of a neoplasm. The gynaecological sonogram showed a solid mass located behind the uterus. Laparotomy confirmed a poorly differentiated ovarian carcinom...

Fernandez-miranda, C.; Mateo, S.; Gonzalez-gomez, C.; Ballestin, C.

1994-01-01

360

Oral Cancer Removal and Palate Reconstruction  

Medline Plus

Full Text Available ... neck surgery. Today, Dr. Browne is going to remove an adenoid cystic carcinoma from the hard palate… [ ... cut inside the upper…the lower lid. Let’s remove that just a second. And we can show ...

361

Tonsillectomy and Adenoidectomy  

Medline Plus

Full Text Available ... professional for your specific condition. ©1995-2012, The Patient Education Institute, Inc. www.X-Plain.com ol040105 Last reviewed: 03/14/2012 1 Swelling and inflammation around the adenoids ...

362

Otitis Media  

Medline Plus

Full Text Available ... to collect in the middle ear. Adenoids are special glands that help fight infections. They are located ... doctors recommend that a child with tubes wear special earplugs while swimming or bathing so that water ...

363

Tonsillectomy and Adenoidectomy  

Medline Plus

Full Text Available ... is the second most common surgery performed on children; however, sometimes it is necessary for adults as ... a tonsillectomy. Repeated middle ear infections in young children, due to swollen adenoids and clogged Eustachian tubes, ...

364

Tonsillectomy and Adenoidectomy  

Medline Plus

Full Text Available ... infections or inflammation. This can sometimes lead to hearing loss. Symptoms & Causes The most common reason that a ... adenoids and clogged Eustachian tubes, can lead to hearing loss. Sometimes hearing loss can cause speech problems. An ...

365

Oral Cancer Removal and Palate Reconstruction  

Medline Plus

Full Text Available ... to remove an adenoid cystic carcinoma from the hard palate… [clears throat]…of a patient here in ... a typical presentation that we see in the hard palate of a minor salivary gland cancer. Minor ...

366

Coblation Assisted Tonsillectomy  

Medline Plus

Full Text Available ... palate to expose the adenoid tissue. At this point, we’d like to go directly to the ... pillar. This is a careful dissection. At this point I’m going to re-grab the tonsil, ...

367

Tonsillectomy and Adenoidectomy  

Medline Plus

Full Text Available ... while sleeping. This condition is known as obstructive sleep apnea or OSA. Taking the tonsils and adenoids help ... of bleeding too much. In cases of obstructive sleep apnea or OSA, the doctor is able to diagnose ...

368

Sleep Apnea (For Parents)  

Science.gov (United States)

... kids and teens can develop it, too. About Sleep Apnea Sleep apnea happens when a person stops breathing ... body movements and sleep positions Back Continue Treating Sleep Apnea If enlarged tonsils or adenoids are thought to ...

369

Coblation Assisted Tonsillectomy  

Medline Plus

Full Text Available ... to the oral cavity. This is called at bending tool. Oftentimes we have to bend the coblation ... thing. NORMAN SANDERS, M.D. How does the bending device work for adenoids? EARL HARLEY, M.D. ...

370

Tonsillectomy and Adenoidectomy  

Medline Plus

Full Text Available ... combined operation is called a T&A. The surgeon may decide to do one or the other, ... ol040105 Last reviewed: 03/14/2012 3 The surgeon removes the tonsils and possibly the adenoids in ...

371

Tonsillectomy and Adenoidectomy  

Medline Plus

Full Text Available ... physical exam that shows enlarged tonsils and adenoids. Procedure A T&A is performed under general anesthesia, ... a T&A, your surgeon can discuss which method he or she will use; one is not ...

372

Tonsillectomy and Adenoidectomy  

Medline Plus

Full Text Available ... a tonsillectomy. Repeated middle ear infections in young children, due to swollen adenoids and clogged Eustachian tubes, can lead to hearing loss. Sometimes hearing loss can cause speech problems. An ...

373

Coblation Assisted Tonsillectomy  

Medline Plus

Full Text Available ... called at bending tool. Oftentimes we have to bend the coblation wand to gain access. Sponges are ... adenoids? EARL HARLEY, M.D. You oftentimes must bend the coblation in order to gain access, so ...

374

Otitis Media  

Medline Plus

Full Text Available ... the Eustachian tube remains plugged, the fluid cannot drain and begins to collect in the middle ear. ... is. Adults’ Eustachian tubes are steeper, so they drain better than children’s do. • Adenoids in children are ...

375

Tonsillectomy and Adenoidectomy  

Medline Plus

Full Text Available ... on both sides of the back of the mouth. The tonsils are part of the immune system ... back, muscular part of the roof of the mouth. The adenoids are also part of the immune ...

376

Tonsillectomy and Adenoidectomy  

Medline Plus

Full Text Available ... Eustachian tubes, can lead to hearing loss. Sometimes hearing loss can cause speech problems. An adenoidectomy may be performed to help prevent middle ear infections. Enlarged tonsils or adenoids can lead to ...

377

Immunohistochemical study of androgen, estrogen and progesterone receptors in salivary gland tumors  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in english The aim of this work was to study the immunohistochemical expression of androgen receptor, estrogen receptor and progesterone receptor in pleomorphic adenomas, Warthin's tumors, mucoepidermoid carcinomas and adenoid cystic carcinomas of salivary glands. A total of 41 pleomorphic adenomas, 30 Warthin [...] 's tumors, 30 mucoepidermoid carcinomas and 30 adenoid cystic carcinomas were analyzed, and the immunohistochemical expression of these hormone receptors were assessed. It was observed that all cases were negative for estrogen and progesterone receptors. Androgen receptor was positive in 2 cases each of pleomorphic adenoma, mucoepidermoid carcinoma and adenoid cystic carcinoma. In conclusion, the results do not support a role of estrogen and progesterone in the tumorigenesis of pleomorphic adenomas, Warthin's tumors, mucoepidermoid carcinomas and adenoid cystic carcinomas. However, androgen receptors can play a role in a small set of salivary gland tumors, and this would deserve further studies.

Fabio Augusto, Ito; Kazuhiro, Ito; Ricardo Della, Coletta; Pablo Agustín, Vargas; Márcio Ajudarte, Lopes.

2009-12-01

378

Immunohistochemical study of androgen, estrogen and progesterone receptors in salivary gland tumors  

Directory of Open Access Journals (Sweden)

Full Text Available The aim of this work was to study the immunohistochemical expression of androgen receptor, estrogen receptor and progesterone receptor in pleomorphic adenomas, Warthin's tumors, mucoepidermoid carcinomas and adenoid cystic carcinomas of salivary glands. A total of 41 pleomorphic adenomas, 30 Warthin's tumors, 30 mucoepidermoid carcinomas and 30 adenoid cystic carcinomas were analyzed, and the immunohistochemical expression of these hormone receptors were assessed. It was observed that all cases were negative for estrogen and progesterone receptors. Androgen receptor was positive in 2 cases each of pleomorphic adenoma, mucoepidermoid carcinoma and adenoid cystic carcinoma. In conclusion, the results do not support a role of estrogen and progesterone in the tumorigenesis of pleomorphic adenomas, Warthin's tumors, mucoepidermoid carcinomas and adenoid cystic carcinomas. However, androgen receptors can play a role in a small set of salivary gland tumors, and this would deserve further studies.

Fabio Augusto Ito

2009-12-01

379

Coblation Assisted Tonsillectomy  

Medline Plus

Full Text Available ... Bovey. Overall, the parents had a better perceived postoperative outcome. One of the most serious complications of ... for adenoids. NORMAN SANDERS, M.D. Are your postoperative results similar for chronic tonsillitis versus hypertrophy? EARL ...

380

Drug: D06965 [KEGG MEDICUS  

Lifescience Database Archive (English)

Full Text Available D06965 Formula, Drug Saikoseikanto Bupleurum root [DR:D06727], Japanese angelica root [DR:D06768 ... ] Nervous disease; Chronic adenoiditis; Ecozema in childhood ... Therapeutic category: 5200 Therapeutic category of ...

381

21 CFR 874.4420 - Ear, nose, and throat manual surgical instrument.  

Science.gov (United States)

...adenoid curette; adenotome; metal tongue depressor; mouth gag; oral screw; salpingeal curette; tonsillectome; tonsil guillotine; tonsil screw; tonsil snare; tonsil suction tube; tonsil suturing hook; antom reforator; ethmoid curette;...

2010-04-01

382

Coblation Assisted Tonsillectomy  

Medline Plus

Full Text Available ... have been tried, with minimal success. While the laser is very precise, it has the same thermal ... to visualize the adenoids. These are clamps and red tubes that we use to retract the palate ...

383

Tonsillectomy and Adenoidectomy  

Medline Plus

Full Text Available ... adenoids help relieve the obstruction and cure OSA. Diagnosis & Treatment Treatment of tonsillitis and ear infections usually ... apnea or OSA, the doctor is able to diagnose the problem on the basis of: • A history ...

384

Tonsillectomy and Adenoidectomy  

Medline Plus

Full Text Available ... infections or inflammation. This can sometimes lead to hearing loss. Symptoms & Causes The most common reason that ... adenoids and clogged Eustachian tubes, can lead to hearing loss. Sometimes hearing loss can cause speech problems. ...

385

A report of laryngeal adenocystic carcinoma metastatic to the spleen and the role of splenectomy in the management of metastatic disease: a case report  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Introduction Adenoid cystic carcinoma (ACC of the larynx is a rare malignancy characterized by an indolent course and late pulmonary metastases. Metastases from the larynx to the spleen are an unusual event. In the present report, we discuss a patient with adenoid cystic carcinoma of the larynx metastatic to the spleen. A review of the literature did not yield any other such incidents. We review the clinical presentation and course of adenoid cystic carcinoma, as well as the role of splenectomy for metastases. Case presentation We present a case of laryngeal adenoid cystic carcinoma in a 26-year-old Caucasian man treated with total laryngectomy and ionizing radiation. He initially developed asynchronous pulmonary metastases, which were resected. Our patient subsequently presented with a symptomatic splenic lesion consistent with metastatic disease, for which he underwent laparoscopic splenectomy. Conclusions Splenectomy might be indicated for isolated metastases. A splenectomy effectively addresses symptoms and serves as a cytoreduction modality.

Murray Bryce W

2010-07-01

386

Primary malignant neoplasms of the lacrimal gland.  

OpenAIRE

The clinical characteristics and outcome of 50 primary malignant neoplasms of the lacrimal gland are reviewed: 38 (76%) adenoid cystic carcinomas, six (12%) carcinomas arising in pleomorphic adenoma, and six (12%) adenocarcinomas or other types of carcinoma. Most patients presented with a short history and pain, though pain tended to occur less often and later with adenocarcinoma than with adenoid cystic carcinoma. Pain was unrelated to the duration of symptoms, invasion of bone, loss of trig...

Wright, J. E.; Rose, G. E.; Garner, A.

1992-01-01

387

Analysis of the role of the gene coding the Amyloid-Precursor Protein Binding Protein 1 (APP-BP1) in the radio-sensitivity of epidermoid carcinomas of the upper aero-digestive tract infected by the human papillomavirus; Analyse du role du gene codant l'Amyloid-Precursor Protein Binding Protein 1 (APP-BP1) dans la radiosensibilite des carcinomes epidermoides des voies aero-digestives superieures infectees par le papillomavirus humain  

Energy Technology Data Exchange (ETDEWEB)

As the human papillomavirus (HPV) is at the origin of 25% of upper aero-digestive tract cancers, and as these tumours present an increased radio-sensitivity compared to other tumours, probably due to a greater transcriptional activity of p53, the authors report the study on the influence of a decrease of the expression of the APP-BP1 in these tumours which could favour a radio-induced apoptosis. By using a reverse transcriptase polymerase chain reaction (RT-PCR), they assessed the APP-BP1 expression levels as well as expression levels of transcriptions coding onco-proteins known to be over-expressed in HPV+ tumours. They compared the radio-sensitivities of HPV+ and HPV- cells, the first one appearing to be greater than the second one. Short communication

Guihard, S.; Altmeyer, A.; Ramolu, L.; Macabre, C.; Abecassis, J.; Noel, G.; Jung, A.C. [Centre de lutte contre le cancer Paul-Strauss, 67 - Strasbourg (France)

2010-10-15

388

Long term follow-up in patients with a naso-pharynx carcinoma after induction chemotherapy by cisplatin, 5-fluoro-uracil and bleomycin (pbf) followed by a bi-fractionated radiotherapy and a consolidation chemotherapy; Survie a long terme chez des patients atteints d'un carcinome du nasopharynx apres chimiotherapie d'induction par cisplatine, 5-fluoro-uracile et bleomycine (pbf) suivie d'une radiotherapie bifractionnee et une chimiotherapie de consolidation  

Energy Technology Data Exchange (ETDEWEB)

The purpose of this study was to evaluate the efficiency and the long term survival after neoadjuvant chemotherapy by cisplatin, 5-fluoro-uracil and bleomycin, followed by a bi fractionated radiotherapy and an adjuvant chemotherapy. The protocol associating a P.B.F. type chemotherapy in the locally evolved disease is justified by its efficiency in terms of objective response rate and local control rate, that expressed by an improvement of the global survival rate and survival without disease at five and ten years. The adjuvant chemotherapy is very toxic and did not show any benefit. (N.C.)

Djekkoun, R.; Boudaoud, K.; Ferdi, N.; Filali, T. [CAC CHU, Constantine (Algeria)

2009-10-15

389

Thyroid transcription factor-1 positive primary breast cancer: a case report with review of the literature  

OpenAIRE

Abstract This case describes an infiltrating breast tumour with thyroid transcription factor-1 (TTF-1) positive staining and ductal differentiation in a 72-year-old woman. The presence of ductal carcinoma in situ with positive TTF-1 is a strong indication that this is a primary tumour and not a metastasis from lung. On PET scan and CT follow up there were no other tumours found in this patient. We are not aware of any previously reported TTF-1 positive primary breast carcinom...

Westre Bjørn; Aas Hans; Gundersen Marian D; Chen Ying; Klingen Tor A; Sauer Torill

2010-01-01

390

Etude de la réplication du VHB et de la réponse à l'intracellulaire à l'infection virale  

OpenAIRE

Le VHB est un problème majeur puisque les 350 millions de porteurs chroniques existant ont un risque accru de développer une cirrhose ou un carcinome hépatocellulaire. Compte tenu du manque de système d'étude du VHB in vitro qui soit facile d'accès et pleinement satisfaisant, l'objectif était d'améliorer l'un de ceux qui utilisent des baculovirus VHB recombinants pour délivrer le génome VHB dans des cellules hépatocytaires. La pertinence de ce système pour réaliser des tests phé...

Lucifora, Julie

2008-01-01

391

Une tumeur rare et distincte du cancer du sein: le carcinosarcome, à propos de huit cas et revue de la littérature  

OpenAIRE

Le carcinosarcome du sein souvent appelé carcinome métaplasique du sein, est une tumeur maligne rare composée de deux lignées cellulaires distinctes, il est décrit comme un cancer du sein de type canalaire avec un composant de type sarcome. Il représente 0,08-0.2% de toutes les tumeurs malignes du sein. Il s'agit d'une étude rétrospective étalée sur un an, huit cas des carcinosarcomes mammaires ont été colligés à l'Institut national d'oncologie au Maroc durant l'année 2007. La ...

Ghanem, Samia; Khoyaali, Siham; Naciri, Sara; Glaoui, Meriem; Mesmoudi, Mohamed; Errihani, Hassan

2013-01-01

392

Osteolytic metastasis detected by F18-FDG PET in a patient with lung carcinoma  

OpenAIRE

We present a 53-year-old man with a vocal cord paralysis observed as a primary manifestation of lung carcinoma. Tc-99m MDP whole body bone scan were performed and resulted a normal scintiscan. The bone scan does not revealed suspicious foci of uptake. The possibility of bone metastasis was taken into consideration. A whole body F18-FDG-PET scan showed intense uptake in the left upper lung corresponding to the primary tumor. A bronchial biopsy confirmed infiltration by small cell lung carcinom...

Gonza?lez Sistal, A?ngel; Baltasar Sa?nchez, Alicia; Sa?nchez Salmo?n, Aida; Ruibal Morell, A?lvaro

2013-01-01

393

UV AND MELANOCORTIN 1 RECEPTORS  

OpenAIRE

Les ultraviolets A (UVA) sont carcinogènes et produisent des espèces réactives de l'oxygène (ERO). Le récepteur à la mélanocortine de type 1 (MC1R) est un récepteur couplé aux protéines G (RCPG) qui est impliqué dans la mélanogénèse et dans l'inflammation cutanée. Certains variants du gène sont associés à un risque accru de mélanomes et de carcinomes cutanés. Le MC1R est exprimé surtout dans les mélanocytes mais son expression peut être induite par les UV in vitro dans ...

Henri, Pauline

2010-01-01

394

Rôle des facteurs de transcription E2F2 et ID3 dans la progression tumorale et intérêt du ciblage de l'aminopeptidase N/CD13 dans le traitement du cancer colique humain  

OpenAIRE

Une analyse génomique (Comparative Genomic Hybridization) a été réalisée sur une cohorte d'adénomes et de tumeurs coliques et a mis en évidence, parmi d'autres altérations, la délétion de la région 1p36.12 dans 23% des adénomes et 47% des carcinomes. Parmi les 15 gènes ayant une fonction connue retrouvés dans cette zone, le gène codant pour le facteur de transcription E2F2 a été retenu en raison de son implication dans des processus cellulaires clés. Une analyse de Kaplan- M...

Voegelin, Manon

2012-01-01

395

RECEPTEURS CUTANES A LA MELANOCORTINE DE TYPE 1 (MC1R) ET REPONSES OXYDATIVES AUX UVA DANS DES KERATINOCYTES HUMAINS HaCaT  

OpenAIRE

Les ultraviolets A (UVA) sont carcinogènes et produisent des espèces réactives de l'oxygène (ERO). Le récepteur à la mélanocortine de type 1 (MC1R) est un récepteur couplé aux protéines G (RCPG) qui est impliqué dans la mélanogénèse et dans l'inflammation cutanée. Certains variants du gène sont associés à un risque accru de mélanomes et de carcinomes cutanés. Le MC1R est exprimé surtout dans les mélanocytes mais son expression peut être induite par les UV in vitro dans ...

Henri, Pauline

2010-01-01

396

La tumeur de Buschke-Lowenstein anorectale: à propos de 16 cas et revue de la littérature  

Science.gov (United States)

La tumeur de Buschke-Lowenstein est une affection rare appartenant au groupe des carcinomes verruqueux. Elle survient le plus souvent chez des sujets pubères en pleine activité sexuelle. Une infection par human papillomavirus (HPV) 6 et 11 est volontiers associée à ces tumeurs. Elle se caractérise par la fréquence des récidives et le risque de transformation maligne. Son traitement est difficile même si l'histologie confirme la bénignité. A partir de 16 observations de TBL et d'une revue de la littérature, les auteurs soulignent les aspects épidémiologiques, cliniques, thérapeutiques et évolutifs de cette affection. PMID:24847393

Njoumi, Noureddine; Tarchouli, Mohamed; Ratbi, Moulay Brahim; Elochi, Mohamed Reda; Yamoul, Rajae; Hachi, Hafid; Bougtab, Abdesslam

2013-01-01

397

Développements statistiques et algorithmiques pour l'analyse des cancers du sein de type triple négatif  

OpenAIRE

Dans le monde, le cancer du sein est le cancer le plus fréquent de la femme. Plusieurs types de cancer du sein ont été mis en évidence. Les carcinomes infiltrants triple négatif (TNBC) sont l'un de ces types. Les TNBC sont parmi les plus agressifs cancers du sein et sont associés à un mauvais pronostique. Il n'y a pas encore de traitement dédié pour ces cancers. Cette thèse avait pour but d'identifier des gènes et des voies de signalisation dérégulés dans les cancers de types TN...

Rigaill, Guillem

2010-01-01

398

Update on lacrimal gland neoplasms: Molecular pathology of interest.  

Science.gov (United States)

Lacrimal gland neoplasms are rare and much of our knowledge of the behavior and molecular pathogenesis of these tumors comes from study of the similar, but more numerous salivary gland neoplasms. After briefly discussing the classification of lacrimal gland neoplasms, I review three areas of emerging knowledge in the pathogenesis of these neoplasms: (1) the concept of adenoid cystic carcinoma with high-grade transformation and the associated cytogenetic changes; (2) recent analysis of the MYB-NFIB gene fusion in adenoid cystic carcinoma, and; (3) overexpression of HER2 in malignant salivary and lacrimal neoplasms. PMID:23960983

White, Valerie A

2012-04-01

399

Tumeurs sub-mandibulaires: profils épidémiologiques et histologiques  

Science.gov (United States)

Introduction Il s'agit de déterminer les profils épidémiologiques et histologiques des tumeurs submandibulaires. Méthodes Il s'agissait d'une étude rétrospective et descriptive de 10 ans (1er janvier 2000 au 31 décembre 2009), réalisée dans le service universitaire d'ORL de l'hôpital de Fann. Etaient inclus dans cette étude tous patients porteurs d'une tumeur submandibulaire (opéré ou non), confirmée par un document histologique. Résultats Vingt-une tumeurs submandibulaires ont été colligées. L’âge moyen des patients était de 34,42 ans (± 14,10), avec des extrêmes de 2 et 55 ans. Quinze patients (71,4%) étaient de sexe féminin, soit un sex-ratio de 0,4. Les résultats histologiques étaient obtenus à partir de 4 biopsies et de 17 pièces opératoires. Dans 13 cas (61,9%) la tumeur était bénigne et dans 8 cas (38,1%) la tumeur était maligne. L'adénome pléomorphe dans 12 cas (57,1%), le carcinome épidermoïde dans 4 cas (19%) et l'adénocarcinome dans 2 cas (9,5%) étaient les types histologiques fréquents. Treize (13) patients étaient porteurs d'une tumeur bénigne, dont huit (8) patients étaient de sexe féminin. Huit (8) patients étaient porteurs d'une tumeur maligne. Sept patients étaient de sexe féminin. Conclusion Cette étude sur les tumeurs submandibulaires est marquée par une prédominance féminine et une fréquence élevée des adénomes pléomorphes et des carcinomes épidermoïdes. PMID:25400831

Essobozou, Pegbessou Plaodezina; Malick, Ndiaye; Evelyne, Diom; Amadou, Thiam; Sanou, Diouf Mame; Djafarou, Boube; Cire, Ndiaye; Abdourhamane, Tall; Karim, Diallo Bay; Cheikh, Ndiaye Issa; Raymond, Diouf; Malick, Diop

2014-01-01

400

Hörstörungen bei Mukopolysaccharidose  

OpenAIRE

Die Mukopolysaccharidosen (MPS) gehören mit einer Erkrankung auf 29000 Geburten zu den seltenen Krankheiten. Die meisten Patienten leiden neben anderem unter Hörstörungen, zumeist Schallleitungsstörungen infolge Tubenfunktionsstörung bei Einlagerung der Speicherstoffe in Adenoide und Pharynxschleimhaut. Deutlich weniger MPS-Patienten leiden an sensorineuralen Schwerhörigkeiten. Wir haben 35 Patienten mit MPS audiologisch untersucht und zeigen die unterschiedliche Verteilung der Schwe...

Napiontek, U.; Keilmann, A.

2004-01-01

401

Delayed tension pneumocephalus complicating orbital exenteration.  

Science.gov (United States)

A 43-year-old woman with a recurrent adenoid cystic carcinoma of the lacrimal gland was treated by orbital exenteration and reconstruction. Eight days later she developed symptoms of cerebral irritation and a computed tomogram showed intracerebral and subarachnoid air. She recovered with conservative treatment. PMID:15749212

Esson, M D; Blanco-Guzman, M; Douglas, P S

2005-04-01

402

Coblation Assisted Tonsillectomy  

Medline Plus

Full Text Available ... the tongue base in a girl with Down’s syndrome who had a large tongue. I’ve used it several times for obstructing inferior turbinates. Many of my children have allergies and have large turbinates and some of their obstruction actually comes from the nose, as opposed to the adenoids, so I’ve ...

403

Drug: D06933 [KEGG MEDICUS  

Lifescience Database Archive (English)

Full Text Available D06933 Formula, Drug Kikyoto Glycyrrhiza [DR:D04365], Platycodon root [DR:D06703] Adenoiditis; P ... inese medicine formulations 52 Traditional Chinese medicines ... 520 Traditional Chinese medicines ... 5200 Traditional ... Chinese medicines ... D06933 Kikyoto Traditional Chinese Medicine in Jap ...

404

Otitis media with effusion  

Science.gov (United States)

... hearing should be tested. If there is significant hearing loss (> 20 decibels), antibiotics or ear tubes might be appropriate. If the fluid is still present after 4 - 6 months, tubes are probably ... hearing loss. Sometimes the adenoids must be removed to restore ...

405

A method for selective endobronchial and endotracheal irradiation.  

Science.gov (United States)

A method for selective endobronchial and endotracheal irradiation is described. This method was used to treat a young woman with an unresectable adenoid cystic carcinoma of the trachea involving the main bronchi. The treatment provided good palliation, as indicated by increase of maximal breathing capacity (MBC) and forced expiratory volume in the first second (FEV1.0). PMID:6283277

Boedker, A; Hald, A; Kristensen, D

1982-07-01

406

Tonsillectomy and Adenoidectomy  

Medline Plus

Full Text Available ... The adenoids are also part of the immune system and help fight infections. The uvula is also located in the back of the mouth. It dangles down from the middle of the soft palate. Behind the uvula, there is a passageway that connects the nose to the mouth. The Eustachian tubes ...

407

[Tumors of different histological type in unilateral salivary glands: a case report].  

Science.gov (United States)

Tumors of synchronous benign and malignant in unilateral salivary glands have rarely been reported. A case of 21-year-old girl who was diagnosed as synchronously adenoid cystic carcinoma of the left parotid and pleomorphic adenoma of the left submandibular gland. The classification, clinic pathology, diagnosis, possible mechanism were discussed based on similar literatures. PMID:21365854

Zhao, Da-Min; He, Hua-Wei; Liu, Mei-Yan; He, Zhi-Xiu

2010-12-01

408

X-Ray Exam: Neck  

Science.gov (United States)

... become lodged in the upper airway or esophagus. Preparation A neck X-ray doesn't require special preparation. Your child may be asked to remove all ... Kids For Parents MORE ON THIS TOPIC CAT Scan: Neck Sinusitis Croup Enlarged Adenoids Getting an X- ...

409

Tonsillectomy and Adenoidectomy  

Medline Plus

Full Text Available ... breathing while sleeping. This condition is known as obstructive sleep apnea or OSA. Taking the tonsils and adenoids help ... risk of bleeding too much. In cases of obstructive sleep apnea or OSA, the doctor is able to diagnose ...

410

Oral Cancer Removal and Palate Reconstruction  

Medline Plus

Full Text Available ... adenoid cystic carcinoma. And what we see is enhancement here of the palatal nerves as they head ... Okay. And we’ll shine this in. Our light’s going and this shows the…muscle. Let’s see, ...

411

Correlation Between Upper Airways Obstructive Indexes in Adenotonsilar Hypertrophy with Mean Pulmonary Arterial Pressure  

Directory of Open Access Journals (Sweden)

Full Text Available Introduction: Hypertrophied tonsils and adenoids may cause upper airway obstruction and cardio-pulmonary complications due to pulmonary arterial hypertension. The aim of this study was to determine the correlation between mean pulmonary arterial pressure (mPAP and selected adenotonsilar hypertrophy indexes. Materials and Methods: Thirty two patients with upper-airway obstruction resulting from hypertrophied tonsils and adenoids were included in our study. Mean pulmonary arterial pressure was measured by a non-invasive method using color doppler echocardiography. Upper airway obstruction was evaluated by clinical OSA (obstructive sleep apnea scoring and also adenoidal-nasopharyngeal (A/N ratio in the lateral neck radiography. Results: Fifty percent of the patients with a normal OSA score, 20% of those with a suspected OSA score and also 50% of cases with OSA had pulmonary hypertension (mPAP>20mmHg which was not statistically significant  (P=0.198.  Mean Adenoidal-nasopharyngeal ratio in patients with a normal mPAP (mPAP?20mmHg was 0.61±0.048 and it was 0.75±0.09 in those with pulmonary hypertension; the difference was statistically significant (P=0.016. Conclusion: It seems that A/N ratio could be used as a predicting factor for increased mPAP in children with upper airway obstruction and a pediatric cardiologist consultation may be necessary before some surgical interventions.

Ehsan Khadivi

2010-07-01

412

Lesiones benignas de mama que pueden simular un carcinoma en estudios imagenológicos / Benign breast lesions that mimic carcinoma in diagnostic imaging  

Scientific Electronic Library Online (English)

Full Text Available SciELO Argentina | Language: Spanish Abstract in spanish La mayoría de las lesiones que se encuentran al realizar estudios mamarios son benignas. Muchas de ellas tienen un aspecto típico y definido, ya sea en mamografía o ecografía y no requieren de evaluaciones adicionales. Existe un grupo de entidades benignas que, sin embargo, puede simular un carcinom [...] a en las imágenes. Los radiólogos debemos conocer las características de las mismas y tenerlas en cuenta como posibles diagnósticos diferenciales de una imagen de alta sospecha. Abstract in english Most of the lesions found during breast imaging exams are benign. Many of them have a typical and definite appearance on mammography and ultrasound, and require no further evaluation. However, some benign lesions cannot be differentiated from carcinomas, given their suspicious and less specific radi [...] ological features. Radiologists should be aware of the imaging characteristics of these lesions and include them in the differential diagnosis of a malignant-appearing finding.

Mariana, Castro Barba; María Paz, Cobos Bombardiere; Flavia, Sarquis; Griselda, Luna; Bárbara, Miller.

2011-03-01

413

In vitro NMR spectroscopy of healthy, mastopathically modified and carcinomatous breast tissue samples correlated with histological findings  

International Nuclear Information System (INIS)

Of 57 patients with clinically suspected mamma carcinoma 121 samples were analysed by in vitro 1H-NMR spectroscopy at 300 MHz and correlated with histological data. Within the relevant spectral region between 2.7 and 4.1 ppm strong signals were observed from fat, (phosphoryl-) choline, (phospho-) creatine, and carnitine. Furthermore, with high regularity, 8 weak, partly overlapping signals were resolved and attributed to glucose, glycine, threonine, serine, inositol, and sucrose. Their intensities were determined by an iterative fitness program. From the intensity ratios, different kinds of tissue could be distinguished based on spectroscopic criteria. Healthy or mastopathically modified tissue could be discriminated from more than 50% carcinomally affected tissue with a specificity of better than 99.5%. This fact is explained by the lower content of fatty acids in the malignant tissue. Differences between spectra of healthy of mastopathically affected tissue were only small. (orig.)

414

Autoradiographic studies and experiments on partical synchronization of human tumors, especially mammary carcinomas, in vitro and in vivo following xenotransplantation to NU/NU mice  

International Nuclear Information System (INIS)

Human mammary carcinomes were evaluated radiographically in vitro in the native state. Penetration dephts up to 552 ?m into the tissue were reached by the incubating medium. The labelling indices for the 3H-thymidine autoradiography lay between 1.5 and 19.3 percent. A correlation of the autoradiographic labelling indices with the findings of a simultaneously performed in vitro sensitivity test against cytostalics could not be proved. There seems to be a relation between the histomorphological tumour image and the proliferation behaviour expressed by the autoradiographic labelling index. Human mammary carcinomes were cultivated as xeno-transplant on thymus-aplastic NU/NU mice in parallel to this investigation. These heterotransplants show a remarkable correlation to the proliferation behaviour of the directly examined human tumours, after an autoradiographic in-vivo-labelling, with index values between 1.5 and 23.8 percent. This parallelism in the biological behaviour represents a further proof for the usefulness of the oncological test model of the NU/NU mouse as a carrier for human cacinomes. The application of this pre-therapeutical test model followed by determination of the synchronization behaviour of three human malignomas after xeno-transplantation onto NU/NU mice. For all three tumous an individual synchronization behaviour could be determined. Therapy attempts followed with cyclophosphonide or ionizing radiation by using the optimal cell-cycle therapy. Therefore an improvement of the therapeutical success by means of pre-therapeutical synchronization of human tumours can be reached in particular cases. (orig./MG)

415

Clinical and pathologic characteristics in patients with tracheobronchial tumor: report of 50 patients.  

Science.gov (United States)

From January, 1961, to July, 1985, 50 patients in the Peking Union Medical College Hospital with intraluminal tracheobronchial tumors were operated on. There was no gender or age predominance either in the 24 patients with tracheal tumor or in the 26 patients with bronchial tumor. The 13 cell types found in these patients' specimens were divided into four groups: malignant, low-grade malignant, benign with tendency to recur and benign without tendency to recur. Squamous cell carcinoma and adenoid cystic carcinoma were the most common tumors of the trachea. Carcinoid and adenoid cystic carcinoma were the most common tumors of the bronchus in this group of patients. Conservative excision with postoperative irradiation may be sufficient for patients with advanced lesions of low-grade malignancy. PMID:3827370

Xu, L T; Sun, Z F; Li, Z J; Wu, L H; Zhang, Z Y; Yu, X Q

1987-03-01

416

[Tumor of the tracheobronchus].  

Science.gov (United States)

Tumors of the tracheobronchus consist of tracheobronchial gland tumor, squamous cell carcinoma, and other tumors. Tracheobronchial gland tumors, such as adenoid cystic carcinoma or mucoepidermoid carcinoma, are rare tumors, and resemble salivary gland tumors pathologically. Surgical complete resection should be considered if possible. Radiotherapy alone results in less survival compared to complete resection. Radiotherapy or palliative bronchoscopic recanalization is a choice of therapy when unresectable. Over all survival rate after operation has been reported to be 66-79% at 5-year and 51-57% at 10-year. Mortality of the surgery is less than 5% in Japan. Adjuvant radiotherapy is often adopted when surgical margin is pathologically positive, since adenoid cystic carcinoma is thought to be radiosensitive tumor. PMID:21916186

Chida, Masayuki

2011-07-01

417

Primary cutaneous mucinous carcinoma initially diagnosed as metastatic adenocarcinoma.  

Science.gov (United States)

The authors report a rare case of primary mucinous carcinoma of the skin initially diagnosed as a metastatic adenocarcinoma. The tumor occurred in the right axilla in a 75-year-old man. Initial pathological diagnosis was metastatic adenocarcinoma. However, no primary focus was found in the body. The revised diagnosis by the authors was primary cutaneous mucinous carcinoma. The tumor (1.5 cm) was characterized by proliferation of atypical epithelial cells arranged in cell nests with many pseudolumens resembling adenoid cystic carcinoma. It was also characterized by much mucinous stroma or pool around tumor cells. No apparent eccrine or apocrine differentiation was noted histologically and immunohistochemically. The present case suggests that primary cutaneous mucinous carcinoma may be misdiagnosed as metastatic adenocarcinoma, and that it may resemble adenoid cystic carcinoma. PMID:15297740

Terada, Tadashi; Sato, Yoshiharu; Furukawa, Kazuo; Sugiura, Makoto

2004-08-01

418

Radiotherapy in epithelial tumors of the parotid gland: Case presentation and literature review  

Energy Technology Data Exchange (ETDEWEB)

A group of 113 patients irradiated for parotid tumor was studied retrospectively. Sixty-two patients were irradiated after superficial parotidectomy or enucleation of a pleomorphic adenoma. None of them had a recurrence after 5-15 years. Sixteen patients were irradiated postoperatively after surgery for a recurrence of pleomorphic adenoma. Only one of them had developed a recurrent tumor. Thirty-five patients with a malignant parotid tumor were treated by irradiation, 22 after surgery and 13 after biopsy only. Patients with a low malignancy tumor (10/11) and adenoid cystic carcinoma (6/12) responded better than patients with a high malignancy carcinoma (2/12). A tumor larger than 4 cm, facial nerve palsy, lymph node metastasis, and inoperability indicate a poor prognosis. With high dose radiotherapy it is possible to treat inoperable tumors successfully. Adenoid cystic carcinomas can respond well to irradiation alone.43 references.

Ravasz, L.A.; Terhaard, C.H.; Hordijk, G.J. (University Hospital Utrecht (Netherlands))

1990-07-01

419

Radiotherapy in epithelial tumors of the parotid gland: Case presentation and literature review  

International Nuclear Information System (INIS)

A group of 113 patients irradiated for parotid tumor was studied retrospectively. Sixty-two patients were irradiated after superficial parotidectomy or enucleation of a pleomorphic adenoma. None of them had a recurrence after 5-15 years. Sixteen patients were irradiated postoperatively after surgery for a recurrence of pleomorphic adenoma. Only one of them had developed a recurrent tumor. Thirty-five patients with a malignant parotid tumor were treated by irradiation, 22 after surgery and 13 after biopsy only. Patients with a low malignancy tumor (10/11) and adenoid cystic carcinoma (6/12) responded better than patients with a high malignancy carcinoma (2/12). A tumor larger than 4 cm, facial nerve palsy, lymph node metastasis, and inoperability indicate a poor prognosis. With high dose radiotherapy it is possible to treat inoperable tumors successfully. Adenoid cystic carcinomas can respond well to irradiation alone.43 references

420

Characteristic karyotypic features in lacrimal and salivary gland carcinomas.  

OpenAIRE

Short-term cultures from 12 non-squamous cell carcinomas (NSCCs) of the head and neck were cytogenetically investigated. Three tumours were acinic cell carcinomas, two adenoid cystic carcinomas, three mucoepidermoid carcinomas, two carcinomas in pleomorphic adenoma, and two adenocarcinomas. Clonal chromosome aberrations were detected in all but one adenocarcinoma. Including our data, a total of 40 head and neck NSCCs with clonal aberrations have been described. Deletions of the long arm of ch...

Jin, Y.; Mertens, F.; Limon, J.; Mandahl, N.; Wennerberg, J.; Dictor, M.; Heim, S.; Mitelman, F.

1994-01-01

421

High dose-rate brachytherapy as a treatment option in primary tracheal tumors Braquiterapia de alta taxa de dose como opção terapêutica nos tumores primários da traquéia  

OpenAIRE

PURPOSE: To present experience with high dose-rate endobronchial brachytherapy in the treatment of primary tracheal tumors. PATIENTS AND METHODS: Four patients with nonresected primary tracheal tumors are presented: 2 cases of squamous cell carcinoma of the trachea, 1 of recurrent adenoid cystic carcinoma, and 1 with recurrent plasmacytoma. All received brachytherapy, alone or as a boost for primary irradiation, in 3 or 4 fractions of 7.5 Gy, calculated at a depth of 1 cm. Follow-up was consi...

Heloisa de Andrade Carvalho; Viviane Figueiredo; Wilson Leite Pedreira Jr.; Salim Aisen

2005-01-01

422

All that wheezes is not asthma.  

Science.gov (United States)

A young woman was admitted with respiratory failure. Prior to her admission, she had been treated for clinical bronchial asthma for about 2 years for recurrent wheezing. Endotracheal intubation was difficult. A fibroptic bronchoscopy, while the patient was ventilated, revealed a central tracheal tumour compromising >90% of the tracheal lumen. The tumour was cored out during rigid bronchoscopy while ventilating the patient through tracheostomy. Histopathology of the tumour was suggestive of adenoid cystic carcinoma. PMID:24577176

Koul, Parvaiz A; Khan, Umar H; Shah, Tajamul Hussain; Dar, Abdul Majid

2014-01-01

423

Tracheal squamous cell carcinoma treated endoscopically.  

Science.gov (United States)

Malignant primary tracheal tumors are extremely rare. The most common malignant primary tracheal tumors are squamous cell carcinoma and adenoid cystic carcinomas. In this brief report, we describe a patient who presented with a primary papillary squamous cell carcinoma in-situ at multiple areas in the trachea with a significant airway obstruction. Our case was successfully managed using a combination of electrocautery and argon photocoagulation for endotracheal ablation of the tumor and adjuvant external beam radiotherapy. PMID:23168962

Ly, Vanthanh; Gupta, Sandeep; Desoto, Fidelina; Cutaia, Michael

2010-10-01

424

Expression of CDK6 in Salivary Gland Tumors  

OpenAIRE

To investigate the expression of CDK6 in salivary gland tumors. In this study, 59 samples of salivary gland tumors from Khalili Hospital pathology archive, including 19 cases of pleomorphic Adenoma, 14 cases of Mucoepidermoid Carcinoma and 19 cases of Adenoid Cystic Carcinoma, as well as 10 cases of normal salivary gland tissue, were reviewed by Immunohistochemistry (IHC) for CDK6 staining. CDK6 expression in normal salivary gland was limited to the cytoplasm of ductal cells, but in tum...

Mohammad Javad Ashraf; Ali Dehghani Najvani; Zohreh Jafari Ashkavandi; Azadeh Andisheh Tadbir; Soheil Pardis; Hoda Ranjbaran

2012-01-01

425

Acantholytic Variant of Bowen's Disease with Micro-invasive Squamous Cell Carcinoma: A Case Report of a Unique Variant  

OpenAIRE

Bowen's disease is generally regarded as premalignant dermatoses. The disease affects both skin and the mucosa and has the potential to progress to invasive squamous cell carcinoma. There are descriptions of several histological variants of Bowen's disease like psoriasiform, atrophic, pagetoid, etc. Acantholysis of anaplastic keratinocytes with bullae/cleft formation is described in premalignant condition like actinic keratosis and adenoid variant of squamous cell carcinoma, but there is lack...

Pai, Kanthilatha; Shetty, Shricharith; Padmapriya, J.; Pai, Sathish; Rao, Lakshmi

2014-01-01

426

A rare cause of respiratory distress in newborn: posterior mediastinal gastroenteric cyst - Case Report  

OpenAIRE

Presentation of mediastinal enteric cysts are rare during neonatal period. They are mostly asymptomatic. The commonest mode of presentation in neonatal period is repiratory distress. Basically, diagnosis of enteric cyst is histologically, for all that vertebral anomalies associated with posterior mediastinal cyst is property of enteric cyst. 0-24h male patient who diagnosed cystic adenoid malformation of lung on prenatal ultrasonographic examination developed respiratory distress at day 4 of...

Erdal Ta?k?n; Kenan Özcan; Mehmet Satar; Nejat Narl?; Ferda Özlü; Hacer Yap?c?o?lu

2011-01-01

427

Incidence of Helicobacter pylori infection and their clarithromycin-resistant strains in otitis media with effusion regarding phenotypic and genotypic studies  

OpenAIRE

Helicobacter pylori (H. pylori) are pathogenic bacteria that infect a half of the human population, colonize gastric mucosa and can be found in gastric juice. Reflux of gastric juice has been suggested to be associated with glue ear in children. It has been suggested that tonsil and adenoid tissues are potential reservoirs of H. pylori infection. These observations raise the question as to whether H. pylori infection might have a role in otitis media with effusion (OME) in children. The objec...

Melake, Nahla A.; Shaker, Ghada H.; Salama, Magdy A.

2012-01-01

428

Mucocèle appendiculaire : à propos d’un cas observé à Lubumbashi  

Directory of Open Access Journals (Sweden)

Full Text Available RESUMELa mucocèle appendiculaire est une entité pathologique rare, mais potentiellement dangereuse ; elle se présente sous différentes formes cliniques. Nous rapportons ici un cas d'une patiente âgée de 49 ans sans antécédents chirurgicaux chez qui nous avons découvert d’une façon fortuite cette affection. La clinique était celle d’un syndrome appendiculaire aigu patent et elle révélait une masse dans la fosse iliaque droite. Les examens de laboratoire ont montré une hyperleucocytose et une vitesse de sédimentation augmentée. L'échographie a démontré une masse kystique péricaecal. La patiente a subi une appendicectomie avec cæcectomie partielle et la pièce opératoire appendiculaire mesurait 153 mm de longueur et 64 mm de diamètre. L’analyse anatomopathologique de celle-ci a confirmé le diagnostic de mucocèle appendiculaire sans cellules de malignité. Les suites opératoires ont été simples et la patiente est sortie au cinquième jour postopératoire. Mots-clés : Mucocèle appendiculaire Tumeur muco-sécrétant appendiculaire ; Appendicite ; LubumbashiSummary The appendiceal mucocele is a rare, but potentially dangerous pathological entity which presents in various clinical forms. We report here a case of a 49-year-old female patient without surgical history to whom we fortuitously discovered this affection. She came with clinical signs of an acute appendicitis and revealed a mass in the right iliac fossa. The examinations of laboratory showed an increase of white cells and of erythrocytes sedimentation rate. The ultrasound revealed a fluid pericaecal mass. The patient underwent an appendectomy with partial cæcectomy. The removed appendix measured 153 mm in length over 64 mm. The pathology confirmed the diagnosis and ruled out a malignant process. The postoperative went well and the patient was discharged on the fifth post-operative day.

KIPILI A

2013-01-01

429

Results of carbon ion radiotherapy for head and neck cancer  

International Nuclear Information System (INIS)

Purpose: To evaluate the efficacy of carbon ion radiotherapy for head-and-neck cancer in a phase II clinical trial. Materials and methods: Between April 1997 and February 2006, 236 patients with locally advanced, histologically proven, and new or recurrent cancer of the head and neck were treated with carbon ions. The treatment dose was 64.0 GyE/16 fractions/4 weeks (or 57.6 GyE/16 fractions/4 weeks when the wide-range skin was included in the target volume). Results: There were grade 3 acute skin reactions in 6% and grade 3 acute mucosal reactions in 10% with no acute reactions worse than grade 3, and grade 2 late skin reactions in 3% and grade 2 late mucosal reactions in 2% with no late reactions worse than grade 2. The 5-year local control rate, by histological type, was 75% for the 85 patients with malignant melanoma, 73% for the 69 with adenoid cystic carcinoma, 73% for the 27 with adenocarcinoma, 61% for the 13 with papillary adenocarcinoma, 61% for the 12 with squamous cell carcinoma and 24% for the 14 with sarcomas. The 5-year over-all survival rate was 68% for adenoid cystic carcinoma, 56% for adenocarcinoma and 35% for malignant melanoma. Conclusions: Carbon ion radiotherapy for head and neck cancer showed the therapeutic effectiveness for malignant melanoma and adenoid cystic carcinoma without severe morbidity of the normal tissues.

430

Evaluation of Ga-67 scintigraphy for salivary gland tumors  

Energy Technology Data Exchange (ETDEWEB)

It is often difficult to exactly grasp the malignancy of salivary gland tumor because of inadaptability of percutaneous biopsy. The purpose of this study is to discuss whether Ga-67 scintigraphy on patient with salivary gland tumor can provide useful information for differential diagnosis. We studied retrospectivelly the case records of twenty patients with parotid or submandibular gland tumors admitted to the Nippon Dental University, School of Dentistry at Niigata, between January 1984 and December 1991. The final diagnoses of these twenty patients were pleomorphic adenoma in 11, adenocarcinoma in 3, adenoid cystic carcinoma in 3, Warthin's tumor in 1, oncocytoma in 1, and carcinoma in pleomorphic adenoma in 1. The scintigraphic patterns of the twenty patients were classified as negative (-), weakly positive (+), moderate positive (++), strongly positive (+++). Malignant tumors showed increased activity in Ga-67 images except those in three patients with adenoid cystic carcinomas. We concluded that Ga-67 scintigraphy may be useful to distinguish benign salivary gland tumors from adenocarcinoma or carcinoma in pleomorphic adenoma, but not be useful in detection of adenoid cystic carcinoma. (author).

Takase, Hiroshi; Toyama, Michio; Eguchi, Tooru; Maeda, Kadzuo (Nippon Dental Univ., Niigata (Japan))

1993-09-01

431

Evaluation of Ga-67 scintigraphy for salivary gland tumors  

International Nuclear Information System (INIS)

It is often difficult to exactly grasp the malignancy of salivary gland tumor because of inadaptability of percutaneous biopsy. The purpose of this study is to discuss whether Ga-67 scintigraphy on patient with salivary gland tumor can provide useful information for differential diagnosis. We studied retrospectivelly the case records of twenty patients with parotid or submandibular gland tumors admitted to the Nippon Dental University, School of Dentistry at Niigata, between January 1984 and December 1991. The final diagnoses of these twenty patients were pleomorphic adenoma in 11, adenocarcinoma in 3, adenoid cystic carcinoma in 3, Warthin's tumor in 1, oncocytoma in 1, and carcinoma in pleomorphic adenoma in 1. The scintigraphic patterns of the twenty patients were classified as negative (-), weakly positive (+), moderate positive (++), strongly positive (+++). Malignant tumors showed increased activity in Ga-67 images except those in three patients with adenoid cystic carcinomas. We concluded that Ga-67 scintigraphy may be useful to distinguish benign salivary gland tumors from adenocarcinoma or carcinoma in pleomorphic adenoma, but not be useful in detection of adenoid cystic carcinoma. (author)

432

Acetylcysteine Rinse in Reducing Saliva Thickness and Mucositis in Patients With Head and Neck Cancer Undergoing Radiation Therapy  

Science.gov (United States)

Mucositis; Oral Complications; Recurrent Adenoid Cystic Carcinoma of the Oral Cavity; Recurrent Basal Cell Carcinoma of the Lip; Recurrent Lymphoepithelioma of the Nasopharynx; Recurrent Lymphoepithelioma of the Oropharynx; Recurrent Mucoepidermoid Carcinoma of the Oral Cavity; Recurrent Salivary Gland Cancer; Recurrent Squamous Cell Carcinoma of the Larynx; Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity; Recurrent Squamous Cell Carcinoma of the Nasopharynx; Recurrent Squamous Cell Carcinoma of the Oropharynx; Recurrent Verrucous Carcinoma of the Larynx; Recurrent Verrucous Carcinoma of the Oral Cavity; Stage I Adenoid Cystic Carcinoma of the Oral Cavity; Stage I Basal Cell Carcinoma of the Lip; Stage I Lymphoepithelioma of the Nasopharynx; Stage I Lymphoepithelioma of the Oropharynx; Stage I Mucoepidermoid Carcinoma of the Oral Cavity; Stage I Salivary Gland Cancer; Stage I Squamous Cell Carcinoma of the Larynx; Stage I Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage I Squamous Cell Carcinoma of the Nasopharynx; Stage I Squamous Cell Carcinoma of the Oropharynx; Stage I Verrucous Carcinoma of the Larynx; Stage I Verrucous Carcinoma of the Oral Cavity; Stage II Adenoid Cystic Carcinoma of the Oral Cavity; Stage II Basal Cell Carcinoma of the Lip; Stage II Lymphoepithelioma of the Nasopharynx; Stage II Lymphoepithelioma of the Oropharynx; Stage II Mucoepidermoid Carcinoma of the Oral Cavity; Stage II Salivary Gland Cancer; Stage II Squamous Cell Carcinoma of the Larynx; Stage II Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage II Squamous Cell Carcinoma of the Nasopharynx; Stage II Squamous Cell Carcinoma of the Oropharynx; Stage II Verrucous Carcinoma of the Larynx; Stage II Verrucous Carcinoma of the Oral Cavity; Stage III Adenoid Cystic Carcinoma of the Oral Cavity; Stage III Basal Cell Carcinoma of the Lip; Stage III Lymphoepithelioma of the Nasopharynx; Stage III Lymphoepithelioma of the Oropharynx; Stage III Mucoepidermoid Carcinoma of the Oral Cavity; Stage III Salivary Gland Cancer; Stage III Squamous Cell Carcinoma of the Larynx; Stage III Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage III Squamous Cell Carcinoma of the Nasopharynx; Stage III Squamous Cell Carcinoma of the Oropharynx; Stage III Verrucous Carcinoma of the Larynx; Stage III Verrucous Carcinoma of the Oral Cavity; Stage IV Lymphoepithelioma of the Nasopharynx; Stage IV Squamous Cell Carcinoma of the Nasopharynx; Stage IVA Adenoid Cystic Carcinoma of the Oral Cavity; Stage IVA Basal Cell Carcinoma of the Lip; Stage IVA Lymphoepithelioma of the Oropharynx; Stage IVA Mucoepidermoid Carcinoma of the Oral Cavity; Stage IVA Salivary Gland Cancer; Stage IVA Squamous Cell Carcinoma of the Larynx; Stage IVA Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage IVA Squamous Cell Carcinoma of the Oropharynx; Stage IVA Verrucous Carcinoma of the Larynx; Stage IVA Verrucous Carcinoma of the Oral Cavity; Stage IVB Adenoid Cystic Carcinoma of the Oral Cavity; Stage IVB Basal Cell Carcinoma of the Lip; Stage IVB Lymphoepithelioma of the Oropharynx; Stage IVB Mucoepidermoid Carcinoma of the Oral Cavity; Stage IVB Salivary Gland Cancer; Stage IVB Squamous Cell Carcinoma of the Larynx; Stage IVB Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage IVB Squamous Cell Carcinoma of the Oropharynx; Stage IVB Verrucous Carcinoma of the Larynx; Stage IVB Verrucous Carcinoma of the Oral Cavity; Stage IVC Adenoid Cystic Carcinoma of the Oral Cavity; Stage IVC Basal Cell Carcinoma of the Lip; Stage IVC Lymphoepithelioma of the Oropharynx; Stage IVC Mucoepidermoid Carcinoma of the Oral Cavity; Stage IVC Salivary Gland Cancer; Stage IVC Squamous Cell Carcinoma of the Larynx; Stage IVC Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage IVC Squamous Cell Carcinoma of the Oropharynx; Stage IVC Verrucous Carcinoma of the Larynx; Stage IVC Verrucous Carcinoma of the Oral Cavity; Tongue Cancer

2014-12-03