Zhou, Qi; Wang, Jun; Huang, Ling; Nie, Wenhui; Wang, Jinhuan; Liu, Yan; Zhao, Xiangyi; Yang, Fengtang; Wang, Wen
2008-01-01
BACKGROUND: The regular mammalian X and Y chromosomes diverged from each other at least 166 to 148 million years ago, leaving few traces of their early evolution, including degeneration of the Y chromosome and evolution of dosage compensation. RESULTS: We studied the intriguing case of black...... muntjac, in which a recent X-autosome fusion and a subsequent large autosomal inversion within just the past 0.5 million years have led to inheritance patterns identical to the traditional X-Y (neo-sex chromosomes). We compared patterns of genome evolution in 35-kilobase noncoding regions and 23 gene...... SNX22 abolished a microRNA target site. Finally, expression analyses revealed complex patterns of expression divergence between neo-Y and neo-X alleles. CONCLUSION: The nascent neo-sex chromosome system of black muntjacs is a valuable model in which to study the evolution of sex chromosomes in mammals...
Characterization of muntjac DNA
Sister chromatid exchange (SCE) in muntjac chromosomes is generally proportional to the chromosomal DNA content, but the SCE frequency is reduced in the heterochromatic neck region of the X chromosome. The physical properties of muntjac DNA and the kinetics of repair of UV damage in muntjac heterochromatin and euchromatin were examined and compared with the distribution of sister chromatid exchange
Characterization of muntjac DNA
Davis, R.C.
1981-05-27
Sister chromatid exchange (SCE) in muntjac chromosomes is generally proportional to the chromosomal DNA content, but the SCE frequency is reduced in the heterochromatic neck region of the X chromosome. The physical properties of muntjac DNA and the kinetics of repair of UV damage in muntjac heterochromatin and euchromatin were examined and compared with the distribution of sister chromatid exchange.
Seasonal food habits of the black muntjac Muntiacus crinifrons%黑麂食物组成及其季节变化
郑荣泉; 鲍毅新
2007-01-01
2002年12月至2003年11月在浙江省九龙山和古田山自然保护区,分季节采集黑麂(Muntiacus crinifrons)粪便,采用粪便显微组织学分析方法为主,辅以野外观察,对其食性进行研究.结果表明:黑麂食物包括29科43种(属)植物.食物中的植物类型包括乔木、灌木、藤本、非禾草类草本和禾草类草本五种类型;灌木是黑麂全年的主要食物,它在食物组成所占的比例为55.4%;三尖杉(Cephalotaxus fortunei)、光叶菝葜(Smilax glabra)、矩圆叶鼠刺(Itea chinensis var.oblonga)、南五味子(Kadsura longipedunculata)和络石(Trachelospermum jasminoides)为黑麂四季都取食且在食物组成中所占比例较高的植物,分别为17%、16.5%、9%、8.7%和4.3%,是黑麂取食的主要食物.方差分析表明:黑麂的主要食物及其主要种类都存在季节变化.夏秋季节,乔木植物在黑麂食物组成的比例低于冬春季节,而藤本植物和草本植物则相反,灌木植物变化较小;黑麂取食的五种主要食物中,其中三尖杉和光叶菝葜季节变化极显著,在冬季,三尖杉和光叶菝葜在食物组成比例中最高,达到21.7%和24.3%;在夏季,它们在食物组成比例中下降到最低点,分别是11.3%和11.6%,但相对密度(RD)值仍保持最高序位;矩圆叶鼠刺和南五味子变化较平缓,基本变化趋势相同:冬春季节比例较高,夏秋季节比例有所下降;络石季节变化不明显;由于黑麂的食物组成中禾草类占的比例很小,说明黑麂更接近嫩食者[动物学报 53(2):201-207,2007].%A combination of field surveys of feeding sites and microhistological analyses of feces was used to study the food habits of black muntjac Muntiacus crinifrons in Gutianshan and Jiulongshan Natural Reserve,Zhejiang Province,China.The plants utilized by black muntjac belong to 43 species and 29 families.These plants fell under five major groups(trees,shrubs,vines,forbs and grasses).Shrubs were the most important
Asri Pudjirahaju
2015-05-01
Full Text Available Knowledge and information about the age of puberty in muntjac (Muntiacus muntjac muntjac isindispensable to the interests of females breeding in conservation efforts. The aims of this study were todetermine the age of puberty and age at first mated females muntjac kept in captivity through the analysisof estrogen and progesterone metabolites in feces. This study used 155 fecal samples that were collectedfrom three female muntjacs. Sample collection was began when muntjac aged three months, four monthsand six months. Total of 10-20 g fecal samples were collected every 2-4 days. Analysis of steroid hormonemetabolites was performed by using enzyme immunoassay (EIA method with specific antibodies.Determination of the age of puberty was based on the appearance of the first time estrus and ovulation,which was indicated by the appearance of the highest estrogens secretion, on hormone metabolites profile.Hormone metabolites data then were tabulated in the average and standard deviations were presentedwith graphs and analyzed descriptively. The results showed that the age of puberty detection based onanalysis of the estrogens and progesterone metabolite in the feces can be applied in muntjac. Muntjacfemales kept in captivity flats reached puberty at age 5±1 month or 4-6 months range. It is recommendedthe first mated in the muntjac is at least after the female experienced two period of oestrous or has reachedat age of six months.
The telomere binding proteins TRF1 and TRF2 maintain and protect chromosome ends and confer karyotypic stability. Chromosome evolution in the genus Muntiacus is characterized by numerous tandem (end-to-end) fusions. To study TRF1 and TRF2 telomere binding proteins in Muntiacus species, we isolated and characterized the TERF1 and -2 genes from Indian muntjac (Muntiacus muntjak vaginalis; 2n = 6 female) and from Chinese muntjac (Muntiacus reveesi; 2n = 46). Expression analysis revealed that both genes are ubiquitously expressed and sequence analysis identified several transcript variants of both TERF genes. Control experiments disclosed a novel testis-specific splice variant of TERF1 in human testes. Amino acid sequence comparisons demonstrate that Muntiacus TRF1 and in particular TRF2 are highly conserved between muntjac and human. In vivo TRF2-GFP and immuno-staining studies in muntjac cell lines revealed telomeric TRF2 localization, while deletion of the DNA binding domain abrogated this localization, suggesting muntjac TRF2 represents a functional telomere protein. Finally, expression analysis of a set of telomere-related genes revealed their presence in muntjac fibroblasts and testis tissue, which suggests the presence of a conserved telomere complex in muntjacs. However, a deviation from the common theme was noted for the TERT gene, encoding the catalytic subunit of telomerase; TERT expression could not be detected in Indian or Chinese muntjac cDNA or genomic DNA using a series of conserved primers, while TRAP assay revealed functional telomerase in Chinese muntjac testis tissues. This suggests muntjacs may harbor a diverged telomerase sequence
Molecular mechanisms of alkylation sensitivity in Indian muntjac cell lines.
Musk, S R; Hatton, D H; Bouffler, S D; Margison, G P; Johnson, R T
1989-07-01
The responses of two Indian muntjac cell lines to two monofunctional alkylating agents were investigated. An SV40-transformed line (SVM) had an increased sensitivity to cell killing when compared to the other, euploid line (DM) after exposure both to methyl nitrosourea (MNU) and to dimethylsulphate (DMS) and also exhibited higher frequencies of sister chromatid exchanges (SCEs) following alkylation. The hypersensitivity of SVM to DMS correlates with the defective repair of single-strand breaks that results in the generation of long-lived breaks in the DNA following exposure, leading eventually to the formation of chromosome aberrations. In contrast no difference is seen in the formation of long-lived breaks in the DNA of SVM and DM after treatment with biologically relevant doses of MNU; in this case hypersensitivity may be due to the loss of O6-alkylguanine-DNA-alkyltransferase activity. The conclusion that the hypersensitivites of SVM to MNU and to DMS have different molecular bases is supported by transfection of SVM with plasmids containing the protein coding region of the Escherichia coli ada+ gene; subsequent expression within the cell corrects its hypersensitivity to the cytotoxic and SCE-inducing effects of MNU but has very little influence upon the lethality, SCE induction or the repair of long-lived DNA strand breaks after exposure to DMS. PMID:2544312
Localization of Sry gene on Y chromosome of Muntjac munticus vaginalis
无
2001-01-01
The chromosomes 1, Y1, Y2 of Muntjac munticus vaginalis were isolated by fluorescence activated chromosome sorting and amplified by degenerate oligonucleotide primed-polymerase chain reaction (DOP-PCR). A primer pair within human Sry HMG box was designed and the Sry gene of the male M. m vaginalis was amplified. The product was cloned and sequenced. The result proved that Sry is located on chromosome Y2, which is the sex-determining chromosome in the male M. m vaginalis.
Reduced glutathione treatment to unstimulated lymphocytes of Muntiacus muntjak 30 min prior to X-irradiation (2, 3 and 4 Gy) reduced the frequency of production of deletions in all the doses of X-ray and that of dicentrics and rings in 3- and 4-Gy exposed cultures. The consistency and degree of protection was more in the case of deletions than dicentrics and rings, and this may be correlated with the dominance in the production of deletions in the muntjac system which might probably be due to either the low chromosome number or a less efficient DNA repair. GSH pretreatment also reduced the radiation-induced cell-cycle delay in 2-Gy exposed cultures almost to the normal level of kinetics. (Auth.)
Sri Wahyuni
2013-07-01
Full Text Available The objective of this study was to describe the histology and histomorphometry of testis and epididymisof muntjac (Muntiacus muntjak muntjak during hard antler period. The tissues of the testis and epididymisof an adult male muntjac were processed for histological examination and stained with haematoxylineosine(HE. The parenchyma of muntjac’s testis during hard antler period showed tubuli seminiferi waslined with germinal epithelium: spermatogonia, spermatocyte, spermatid that differentiated intospermatozoa. Sertoli cells were found among the germinal cells. In addition, Leydig cells were foundaround the blood vessel of interstitial tissue along with macrophages. Diameter of the seminiferous tubuleand epithelial thickness were 176,60±7,06 ?m and 50,27±3,62 ?m respectively. The epididymal duct wassubdivided into three segments: caput, corpus and cauda. They were lined predominantly withpseudostratified columnar epithelium which was varied in its thickness. The largest diameter of epididymalduct was found in cauda region (324,26±25,79 ?m, while caput epididymidis had the thickest of epithelialcell (62,21±4,21 ?m and tended to ce thinner in corpus (49,53±3,01 ?m and cauda epididymidis(16,30±2,27?m. The density of spermatozoa was observed the most in the lumen of cauda region comparedto caput and corpus epididymidis. In conclusion, the structure of histology and histomorphometry of theseminiferous tubule of testis and epididymal duct of muntjac were similar with small ruminants andother Cervidae during hard antler period.
Ontogeny tends to recapitulate phylogeny in digital organisms.
Clune, Jeff; Pennock, Robert T; Ofria, Charles; Lenski, Richard E
2012-09-01
Biologists have long debated whether ontogeny recapitulates phylogeny and, if so, why. Two plausible explanations are that (i) changes to early developmental stages are selected against because they tend to disrupt later development and (ii) simpler structures often precede more complex ones in both ontogeny and phylogeny if the former serve as building blocks for the latter. It is difficult to test these hypotheses experimentally in natural systems, so we used a computational system that exhibits evolutionary dynamics. We observed that ontogeny does indeed recapitulate phylogeny; traits that arose earlier in a lineage's history also tended to be expressed earlier in the development of individuals. The relative complexity of traits contributed substantially to this correlation, but a significant tendency toward recapitulation remained even after accounting for trait complexity. This additional effect provides evidence that selection against developmental disruption also contributed to the conservation of early stages in development. PMID:22854085
Retinal Organoids from Pluripotent Stem Cells Efficiently Recapitulate Retinogenesis
Manuela Völkner; Marlen Zschätzsch; Maria Rostovskaya; Rupert W. Overall; Volker Busskamp; Konstantinos Anastassiadis; Mike O. Karl
2016-01-01
Summary The plasticity of pluripotent stem cells provides new possibilities for studying development, degeneration, and regeneration. Protocols for the differentiation of retinal organoids from embryonic stem cells have been developed, which either recapitulate complete eyecup morphogenesis or maximize photoreceptor genesis. Here, we have developed a protocol for the efficient generation of large, 3D-stratified retinal organoids that does not require evagination of optic-vesicle-like structur...
Retinal Organoids from Pluripotent Stem Cells Efficiently Recapitulate Retinogenesis.
Völkner, Manuela; Zschätzsch, Marlen; Rostovskaya, Maria; Overall, Rupert W; Busskamp, Volker; Anastassiadis, Konstantinos; Karl, Mike O
2016-04-12
The plasticity of pluripotent stem cells provides new possibilities for studying development, degeneration, and regeneration. Protocols for the differentiation of retinal organoids from embryonic stem cells have been developed, which either recapitulate complete eyecup morphogenesis or maximize photoreceptor genesis. Here, we have developed a protocol for the efficient generation of large, 3D-stratified retinal organoids that does not require evagination of optic-vesicle-like structures, which so far limited the organoid yield. Analysis of gene expression in individual organoids, cell birthdating, and interorganoid variation indicate efficient, reproducible, and temporally regulated retinogenesis. Comparative analysis of a transgenic reporter for PAX6, a master regulator of retinogenesis, shows expression in similar cell types in mouse in vivo, and in mouse and human retinal organoids. Early or late Notch signaling inhibition forces cell differentiation, generating organoids enriched with cone or rod photoreceptors, respectively, demonstrating the power of our improved organoid system for future research in stem cell biology and regenerative medicine. PMID:27050948
Non-Small-Cell Lung Cancer Molecular Signatures Recapitulate Lung Developmental Pathways
Borczuk, Alain C.; Gorenstein, Lyall; Walter, Kristin L.; Assaad, Adel A.; Wang, Liqun; Powell, Charles A.
2003-01-01
Current paradigms hold that lung carcinomas arise from pleuripotent stem cells capable of differentiation into one or several histological types. These paradigms suggest lung tumor cell ontogeny is determined by consequences of gene expression that recapitulate events important in embryonic lung development. Using oligonucleotide microarrays, we acquired gene profiles from 32 microdissected non-small-cell lung tumors. We determined the 100 top-ranked marker genes for adenocarcinoma, squamous ...
Langkjær, Michael Alexander
2012-01-01
Pop musicians performing in black stage costume take advantage of cultural traditions relating to matters black. Stylistically, black is a paradoxical color: although a symbol of melancholy, pessimism, and renunciation, black also expresses minimalist modernity and signifies exclusivity (as...... is hinted by Rudyard Kipling’s illustration of ‘The [Black] Cat That Walked by Himself’ in his classic children’s tale). It was well understood by uniformed Anarchists, Fascists and the SS that there is an assertive presence connected with the black-clad figure. The paradox of black’s abstract elegance......-styled references to, among other things, the culturally and ideologically effervescent interwar-period have made me curious as to what alternative possibilities – for instance ‘emancipation’ – a comparative analysis might disclose concerning the visual rhetoric of black. Thus, in conclusion, it is briefly...
Jung, David; Bassing, Craig H; Fugmann, Sebastian D; Cheng, Hwei-Ling; Schatz, David G; Alt, Frederick W
2003-01-01
V(D)J recombination occurs efficiently only between gene segments flanked by recombination signals (RSs) containing 12 and 23 base pair spacers (the 12/23 rule). A further limitation "beyond the 12/23 rule" (B12/23) exists at the TCRbeta locus and ensures Dbeta usage. Herein, we show that extrachromosomal V(D)J recombination substrates recapitulate B12/23 restriction in nonlymphoid cells. We further demonstrate that the Vbeta coding flank, the 12-RS heptamer/nonamer, and the 23-RS spacer each can significantly influence B12/23 restriction. Finally, purified core RAG1 and RAG2 proteins (together with HMG2) also reproduce B12/23 restriction in a cell-free system. Our findings indicate that B12/23 restriction of V(D)J recombination is cemented at the level of interactions between the RAG proteins and TCRbeta RS sequences. PMID:12530976
The Genetics of Mexico Recapitulates Native American Substructure and Affects Biomedical Traits
Moreno-Estrada, Andrés; Gignoux, Christopher R.; Fernández-López, Juan Carlos; Zakharia, Fouad; Sikora, Martin; Contreras, Alejandra V.; Acuña-Alonzo, Victor; Sandoval, Karla; Eng, Celeste; Romero-Hidalgo, Sandra; Ortiz-Tello, Patricia; Robles, Victoria; Kenny, Eimear E.; Nuño-Arana, Ismael; Barquera-Lozano, Rodrigo; Macín-Pérez, Gastón; Granados-Arriola, Julio; Huntsman, Scott; Galanter, Joshua M.; Via, Marc; Ford, Jean G.; Chapela, Rocío; Rodriguez-Cintron, William; Rodríguez-Santana, Jose R.; Romieu, Isabelle; Sienra-Monge, Juan José; Navarro, Blanca del Rio; London, Stephanie J.; Ruiz-Linares, Andrés; Garcia-Herrera, Rodrigo; Estrada, Karol; Hidalgo-Miranda, Alfredo; Jimenez-Sanchez, Gerardo; Carnevale, Alessandra; Soberón, Xavier; Canizales-Quinteros, Samuel; Rangel-Villalobos, Héctor; Silva-Zolezzi, Irma; Burchard, Esteban Gonzalez; Bustamante, Carlos D.
2014-01-01
Mexico harbors great cultural and ethnic diversity, yet fine-scale patterns of human genome-wide variation from this region remain largely uncharacterized. We studied genomic variation within Mexico from over 1,000 individuals representing 20 indigenous and 11 mestizo populations. We found striking genetic stratification among indigenous populations within Mexico at varying degrees of geographic isolation. Some groups were as differentiated as Europeans are from East Asians. Pre-Columbian genetic substructure is recapitulated in the indigenous ancestry of admixed mestizo individuals across the country. Furthermore, two independently phenotyped cohorts of Mexicans and Mexican Americans showed a significant association between sub-continental ancestry and lung function. Thus, accounting for fine-scale ancestry patterns is critical for medical and population genetic studies within Mexico, in Mexican-descent populations, and likely in many other populations worldwide. PMID:24926019
Fei Zhu
Full Text Available BACKGROUND: Excessive mechanical loading of articular cartilage producing hydrostatic stress, tensile strain and fluid flow leads to irreversible cartilage erosion and osteoarthritic (OA disease. Since application of high fluid shear to chondrocytes recapitulates some of the earmarks of OA, we aimed to screen the gene expression profiles of shear-activated chondrocytes and assess potential similarities with OA chondrocytes. METHODOLOGY/PRINCIPAL FINDINGS: Using a cDNA microarray technology, we screened the differentially-regulated genes in human T/C-28a2 chondrocytes subjected to high fluid shear (20 dyn/cm(2 for 48 h and 72 h relative to static controls. Confirmation of the expression patterns of select genes was obtained by qRT-PCR. Using significance analysis of microarrays with a 5% false discovery rate, 71 and 60 non-redundant transcripts were identified to be ≥2-fold up-regulated and ≤0.6-fold down-regulated, respectively, in sheared chondrocytes. Published data sets indicate that 42 of these genes, which are related to extracellular matrix/degradation, cell proliferation/differentiation, inflammation and cell survival/death, are differentially-regulated in OA chondrocytes. In view of the pivotal role of cyclooxygenase-2 (COX-2 in the pathogenesis and/or progression of OA in vivo and regulation of shear-induced inflammation and apoptosis in vitro, we identified a collection of genes that are either up- or down-regulated by shear-induced COX-2. COX-2 and L-prostaglandin D synthase (L-PGDS induce reactive oxygen species production, and negatively regulate genes of the histone and cell cycle families, which may play a critical role in chondrocyte death. CONCLUSIONS/SIGNIFICANCE: Prolonged application of high fluid shear stress to chondrocytes recapitulates gene expression profiles associated with osteoarthritis. Our data suggest a potential link between exposure of chondrocytes/cartilage to abnormal mechanical loading and the pathogenesis
A black ring is a five-dimensional black hole with an event horizon of topology S1 x S2. We provide an introduction to the description of black rings in general relativity and string theory. Novel aspects of the presentation include a new approach to constructing black ring coordinates and a critical review of black ring microscopics. (topical review)
Hraba, Joseph; Siegman, Jack
1974-01-01
Black militancy is treated as an instance of class consciousness with criteria and scales developed to measure black consciousness and "self-placement" into black consciousness. These dimensions are then investigated with respect to the social and symbolic participation in the ideology of the black movement on the part of a sample of black…
Recapitulating the Size and Cargo of Tumor Exosomes in a Tissue-Engineered Model
Villasante, Aranzazu; Marturano-Kruik, Alessandro; Ambati, Srikanth R.; Liu, Zen; Godier-Furnemont, Amandine; Parsa, Hesam; Lee, Benjamin W.; Moore, Malcolm A.S.; Vunjak-Novakovic, Gordana
2016-01-01
There is a growing interest in the pivotal role of exosomes in cancer and in their use as biomarkers. However, despite the importance of the microenvironment for cancer initiation and progression, monolayer cultures of tumor cells still represent the main in vitro source of exosomes. As a result, their environmental regulation remains largely unknown. Here, we report a three-dimensional tumor model for studying exosomes, using Ewing's sarcoma type 1 as a clinically relevant example. The bioengineered model was designed based on the hypothesis that the 3-dimensionality, composition and stiffness of the tumor matrix are the critical determinants of the size and cargo of exosomes released by the cancer cells. We analyzed the effects of the tumor microenvironment on exosomes, and the effects of exosomes on the non-cancer cells from the bone niche. Exosomes from the tissue-engineered tumor had similar size distribution as those in the patients' plasma, and were markedly smaller than those in monolayer cultures. Bioengineered tumors and the patients' plasma contained high levels of the Polycomb histone methyltransferase EZH2 mRNA relatively to their monolayer counterparts. Notably, EZH2 mRNA, a potential tumor biomarker detectable in blood plasma, could be transferred to the surrounding mesenchymal stem cells. This study provides the first evidence that an in vitro culture environment can recapitulate some properties of tumor exosomes. PMID:27279906
Kong, Lingbing; Almond, Andrew; Bayley, Hagan; Davis, Benjamin G.
2016-05-01
The outermost protective layer of both Gram-positive and Gram-negative bacteria is composed of bacterial capsular polysaccharides. Insights into the interactions between the capsular polysaccharide and its transporter and the mechanism of sugar export would not only increase our understanding of this key process, but would also help in the design of novel therapeutics to block capsular polysaccharide export. Here, we report a nanolitre detection system that makes use of the bilayer interface between two droplets, and we use this system to study single-molecule recapitulation of sugar export. A synthetic strategy of polyglycosylation based on tetrasaccharide monomers enables ready synthetic access to extended fragments of K30 oligosaccharides and polysaccharides. Examination of the interactions between the Escherichia coli sugar transporter Wza and very small amounts of fragments of the K30 capsular polysaccharide substrate reveal the translocation of smaller but not larger fragments. We also observe capture events that occur only on the intracellular side of Wza, which would complement coordinated feeding by adjunct biosynthetic machinery.
Robert Nunan
2014-11-01
Full Text Available The efficient healing of a skin wound is something that most of us take for granted but is essential for surviving day-to-day knocks and cuts, and is absolutely relied on clinically whenever a patient receives surgical intervention. However, the management of a chronic wound – defined as a barrier defect that has not healed in 3 months – has become a major therapeutic challenge throughout the Western world, and it is a problem that will only escalate with the increasing incidence of conditions that impede wound healing, such as diabetes, obesity and vascular disorders. Despite being clinically and molecularly heterogeneous, all chronic wounds are generally assigned to one of three major clinical categories: leg ulcers, diabetic foot ulcers or pressure ulcers. Although we have gleaned much knowledge about the fundamental cellular and molecular mechanisms that underpin healthy, acute wound healing from various animal models, we have learned much less about chronic wound repair pathology from these models. This might largely be because the animal models being used in this field of research have failed to recapitulate the clinical features of chronic wounds. In this Clinical Puzzle article, we discuss the clinical complexity of chronic wounds and describe the best currently available models for investigating chronic wound pathology. We also assess how such models could be optimised to become more useful tools for uncovering pathological mechanisms and potential therapeutic treatments.
Ben-Reuven, Lihi; Reiner, Orly
2016-06-01
The opportunity to model autism spectrum disorders (ASD) through generation of patient-derived induced pluripotent stem cells (iPSCs) is currently an emerging topic. Wide-scale research of altered brain circuits in syndromic ASD, including Rett Syndrome, Fragile X Syndrome, Angelman's Syndrome and sporadic Schizophrenia, was made possible through animal models. However, possibly due to species differences, and to the possible contribution of epigenetics in the pathophysiology of these diseases, animal models fail to recapitulate many aspects of ASD. With the advent of iPSCs technology, 3D cultures of patient-derived cells are being used to study complex neuronal phenotypes, including both syndromic and nonsyndromic ASD. Here, we review recent advances in using iPSCs to study various aspects of the ASD neuropathology, with emphasis on the efforts to create in vitro model systems for syndromic and nonsyndromic ASD. We summarize the main cellular activity phenotypes and aberrant genetic interaction networks that were found in iPSC-derived neurons of syndromic and nonsyndromic autistic patients. PMID:27111774
Pascual-Pasto, Guillem; Olaciregui, Nagore G; Vila-Ubach, Monica; Paco, Sonia; Monterrubio, Carles; Rodriguez, Eva; Winter, Ursula; Batalla-Vilacis, Mireia; Catala, Jaume; Salvador, Hector; Parareda, Andreu; Schaiquevich, Paula; Suñol, Mariona; Mora, Jaume; Lavarino, Cinzia; de Torres, Carmen; Chantada, Guillermo L; Carcaboso, Angel M
2016-09-28
Translational research in retinoblastoma - a pediatric tumor that originates during the development of the retina - would be improved by the creation of new patient-derived models. Using tumor samples from enucleated eyes we established a new battery of preclinical models that grow in vitro in serum-free medium and in vivo in immunodeficient mice. To examine whether the new xenografts recapitulate human disease and disseminate from the retina to the central nervous system, we evaluated their histology and the presence of molecular markers of dissemination that are used in the clinical setting to detect extraocular metastases. We evaluated GD2 synthase and CRX as such markers and generated a Taqman real-time quantitative PCR method to measure CRX mRNA for rapid, sensitive and specific quantification of local and metastatic tumor burden. This approach was able to detect 1 human retinoblastoma cell in 100.000 mouse brain cells. Our research adds novel preclinical tools for the discovery of new retinoblastoma treatments for clinical translation. PMID:27319373
Kong, Lingbing; Almond, Andrew; Bayley, Hagan; Davis, Benjamin G
2016-05-01
The outermost protective layer of both Gram-positive and Gram-negative bacteria is composed of bacterial capsular polysaccharides. Insights into the interactions between the capsular polysaccharide and its transporter and the mechanism of sugar export would not only increase our understanding of this key process, but would also help in the design of novel therapeutics to block capsular polysaccharide export. Here, we report a nanolitre detection system that makes use of the bilayer interface between two droplets, and we use this system to study single-molecule recapitulation of sugar export. A synthetic strategy of polyglycosylation based on tetrasaccharide monomers enables ready synthetic access to extended fragments of K30 oligosaccharides and polysaccharides. Examination of the interactions between the Escherichia coli sugar transporter Wza and very small amounts of fragments of the K30 capsular polysaccharide substrate reveal the translocation of smaller but not larger fragments. We also observe capture events that occur only on the intracellular side of Wza, which would complement coordinated feeding by adjunct biosynthetic machinery. PMID:27102680
Hidetoshi Kassai
2014-06-01
Full Text Available Mammalian target of rapamycin (mTOR has been implicated in human neurological diseases such as tuberous sclerosis complex (TSC, neurodegeneration, and autism. However, little is known about when and how mTOR is involved in the pathogenesis of these diseases, due to a lack of animal models that directly increase mTOR activity. Here, we generated transgenic mice expressing a gain-of-function mutant of mTOR in the forebrain in a temporally controlled manner. Selective activation of mTORC1 in embryonic stages induced cortical atrophy caused by prominent apoptosis of neuronal progenitors, associated with upregulation of HIF-1α. In striking contrast, activation of the mTORC1 pathway in adulthood resulted in cortical hypertrophy with fatal epileptic seizures, recapitulating human TSC. Activated mTORC1 in the adult cortex also promoted rapid accumulation of cytoplasmic inclusions and activation of microglial cells, indicative of progressive neurodegeneration. Our findings demonstrate that mTORC1 plays different roles in developmental and adult stages and contributes to human neurological diseases.
Cardona, Tanai
2016-01-01
Due to the great abundance of genomes and protein structures that today span a broad diversity of organisms, now more than ever before, it is possible to reconstruct the molecular evolution of protein complexes at an incredible level of detail. Here, I recount the story of oxygenic photosynthesis or how an ancestral reaction center was transformed into a sophisticated photochemical machine capable of water oxidation. First, I review the evolution of all reaction center proteins in order to highlight that Photosystem II and Photosystem I, today only found in the phylum Cyanobacteria, branched out very early in the history of photosynthesis. Therefore, it is very unlikely that they were acquired via horizontal gene transfer from any of the described phyla of anoxygenic phototrophic bacteria. Second, I present a new evolutionary scenario for the origin of the CP43 and CP47 antenna of Photosystem II. I suggest that the antenna proteins originated from the remodeling of an entire Type I reaction center protein and not from the partial gene duplication of a Type I reaction center gene. Third, I highlight how Photosystem II and Photosystem I reaction center proteins interact with small peripheral subunits in remarkably similar patterns and hypothesize that some of this complexity may be traced back to the most ancestral reaction center. Fourth, I outline the sequence of events that led to the origin of the Mn4CaO5 cluster and show that the most ancestral Type II reaction center had some of the basic structural components that would become essential in the coordination of the water-oxidizing complex. Finally, I collect all these ideas, starting at the origin of the first reaction center proteins and ending with the emergence of the water-oxidizing cluster, to hypothesize that the complex and well-organized process of assembly and photoactivation of Photosystem II recapitulate evolutionary transitions in the path to oxygenic photosynthesis. PMID:26973693
Trim37-deficient mice recapitulate several features of the multi-organ disorder Mulibrey nanism.
Kettunen, Kaisa M; Karikoski, Riitta; Hämäläinen, Riikka H; Toivonen, Teija T; Antonenkov, Vasily D; Kulesskaya, Natalia; Voikar, Vootele; Hölttä-Vuori, Maarit; Ikonen, Elina; Sainio, Kirsi; Jalanko, Anu; Karlberg, Susann; Karlberg, Niklas; Lipsanen-Nyman, Marita; Toppari, Jorma; Jauhiainen, Matti; Hiltunen, J Kalervo; Jalanko, Hannu; Lehesjoki, Anna-Elina
2016-01-01
Mulibrey nanism (MUL) is a rare autosomal recessive multi-organ disorder characterized by severe prenatal-onset growth failure, infertility, cardiopathy, risk for tumors, fatty liver, and type 2 diabetes. MUL is caused by loss-of-function mutations in TRIM37, which encodes an E3 ubiquitin ligase belonging to the tripartite motif (TRIM) protein family and having both peroxisomal and nuclear localization. We describe a congenic Trim37 knock-out mouse (Trim37(-/-)) model for MUL. Trim37(-/-) mice were viable and had normal weight development until approximately 12 months of age, after which they started to manifest increasing problems in wellbeing and weight loss. Assessment of skeletal parameters with computer tomography revealed significantly smaller skull size, but no difference in the lengths of long bones in Trim37(-/-) mice as compared with wild-type. Both male and female Trim37(-/-) mice were infertile, the gonads showing germ cell aplasia, hilus and Leydig cell hyperplasia and accumulation of lipids in and around Leydig cells. Male Trim37(-/-) mice had elevated levels of follicle-stimulating and luteinizing hormones, but maintained normal levels of testosterone. Six-month-old Trim37(-/-) mice had elevated fasting blood glucose and low fasting serum insulin levels. At 1.5 years Trim37(-/-) mice showed non-compaction cardiomyopathy, hepatomegaly, fatty liver and various tumors. The amount and morphology of liver peroxisomes seemed normal in Trim37(-/-) mice. The most consistently seen phenotypes in Trim37(-/-) mice were infertility and the associated hormonal findings, whereas there was more variability in the other phenotypes observed. Trim37(-/-) mice recapitulate several features of the human MUL disease and thus provide a good model to study disease pathogenesis related to TRIM37 deficiency, including infertility, non-alcoholic fatty liver disease, cardiomyopathy and tumorigenesis. PMID:27044324
Meng, Xianmin; Klement, John F; Leperi, Dominic A; Birk, David E; Sasaki, Takako; Timpl, Rupert; Uitto, Jouni; Pulkkinen, Leena
2003-10-01
Junctional forms of epidermolysis bullosa (JEB) are associated with mutations in six distinct genes expressed in the cutaneous basement membrane zone; these include LAMA3, LAMB3, and LAMC2, which encode laminin 5 subunit polypeptides, the alpha3-, beta3-, and gamma2-chains, respectively. Here we generated a mouse model for JEB by inactivating the laminin gamma2-chain gene by targeted frameshift deletion of exon 8 in Lamc2. Heterozygous mice were phenotypically normal, whereas the majority of Lamc2-/- mice showed blistering phenotype on days 1 to 2 and died within 5 days of birth. The Lamc2-/- mice demonstrated absent expression of laminin gamma2-chain on the basement membrane zone as well as attenuated expression of alpha3- and beta3-chains of laminin. Transmission electron microscopy revealed rudimentary, poorly developed hemidesmosomes. The epidermis of the Lamc2-/- mice revealed induced apoptosis in the basal cells of the blistered skin, suggesting that cell-matrix adhesion provided by laminin 5 plays a role in cell survival in vivo. Cultured Lamc2-/- keratinocytes demonstrated slightly positive staining with gamma2-chain-specific antibodies, which could be explained by the presence of a transcript with partial restoration of the reading frame owing to alternative splicing in vitro. These cells proliferated in different matrices and attached to type IV collagen and Matrigel as efficiently as the wild-type keratinocytes, whereas their attachment on plastic and laminin was significantly weaker. In summary, Lamc2-/- mouse recapitulates human JEB and provides novel insight into the role of laminin 5 in keratinocyte biology. PMID:14632187
The Grooved Rodent Incisor Recapitulates Rudimentary Teeth Characteristics of Ancestral Mammals.
Li, L; Tang, Q; Jung, H-S
2016-07-01
It is known from the paleontology studies of eutherian mammals that incisor numbers were reduced during evolution. The evolutionary lost incisors may remain as vestigial structures at embryonic stages. The recapitulation of the incisor patterns among mammalian species will potentially uncover the mechanisms underlying the phenotypic transition of incisors during evolution. Here, we showed that a minute tooth formed in the presumptive groove region of the gerbil upper incisor at the early developmental stages, during which multiple epithelial swellings and Shh transcription domains spatiotemporally appeared in the dental epithelium, suggests the existence of vestigial dental primordia. Interestingly, when we trimmed the surrounding mesenchyme from incisor tooth germs at or before the bud stage prior to ex vivo culture, the explants developed different incisor phenotypes ranging from triplicated incisors, duplicated incisors, to Lagomorpha-like incisors, corresponding to the incisor patterns in the eutherian mammals. These results imply that the phenotypic transition of incisors during evolution, as well as the achievement of ultimate incisors in adults, arose from differential integrations of primordia. However, when the incisor tooth germ was trimmed at the cap stage, a grooved incisor developed similar to the normal condition. Furthermore, the incisor tooth germ developed a small but smooth incisor after the additional removal of the minute tooth and a lateral rudiment. These results suggest that multiple dental primordia integrated before the cap stage, with the labial primordia contributing to the labial face of the functional incisor. The minute tooth that occupied the boundary of the 2 labial primordia might be implicated in the groove formation. This study sheds light on how rudiments incorporate into functional organs and aids the understanding of incisor evolution. PMID:26912224
Umemura, Yasuhiro; Yoshida, Junko; Wada, Masashi; Tsuchiya, Yoshiki; Minami, Yoichi; Watanabe, Hitomi; Kondoh, Gen; Takeda, Junji; Inokawa, Hitoshi; Horie, Kyoji; Yagita, Kazuhiro
2013-01-01
We previously reported emergence and disappearance of circadian molecular oscillations during differentiation of mouse embryonic stem (ES) cells and reprogramming of differentiated cells, respectively. Here we present a robust and stringent in vitro circadian clock formation assay that recapitulates in vivo circadian phenotypes. This assay system first confirmed that a mutant ES cell line lacking Casein Kinase I delta (CKIδ) induced ∼3 hours longer period-length of circadian rhythm than the w...
Mutant LRRK2R1441G BAC transgenic mice recapitulate cardinal features of Parkinson’s disease
Li, Yanping; Liu, Wencheng; Oo, Tinmarla F.; Wang, Lei; Tang, Yi; Jackson-Lewis, Vernice; Zhou, Chun; Geghman, Kindiya; Bogdanov, Mikhail; Przedborski, Serge; Beal, M. Flint; Burke, Robert E.; Li, Chenjian
2009-01-01
Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common genetic cause of Parkinson’s disease. We created a LRRK2 transgenic mouse model that recapitulates cardinal features of the disease: an age-dependent and levodopa-responsive slowness of movement associated with diminished dopamine release and axonal pathology of nigrostriatal dopaminergic projection. These mice provide a valid model of Parkinson’s disease and are a resource for the investigation of pathogenesis and therapeu...
Nigim, Fares; Cavanaugh, Jill; Patel, Anoop P.; Curry, William T.; Esaki, Shin-ichi; Kasper, Ekkehard M.; Chi, Andrew S.; Louis, David N.; Martuza, Robert L.; Rabkin, Samuel D.; Wakimoto, Hiroaki
2015-01-01
Tissue hypoxia and necrosis represent pathophysiological and histological hallmarks of glioblastoma (GBM). Although hypoxia inducible factor 1α (HIF-1α) plays crucial roles in the malignant phenotypes of GBM, developing HIF-1α-targeted agents has been hampered by the lack of a suitable preclinical model that recapitulates the complex biology of clinical GBM. We present a new GBM model, MGG123, which was established from a recurrent human GBM. Orthotopic xenografting of stem-...
Ramírez-Chaves, Héctor E; Wroe, Stephen W; Selwood, Lynne; Hinds, Lyn A; Leigh, Chris; Koyabu, Daisuke; Kardjilov, Nikolay; Weisbecker, Vera
2016-01-13
The ectotympanic, malleus and incus of the developing mammalian middle ear (ME) are initially attached to the dentary via Meckel's cartilage, betraying their origins from the primary jaw joint of land vertebrates. This recapitulation has prompted mostly unquantified suggestions that several suspected--but similarly unquantified--key evolutionary transformations leading to the mammalian ME are recapitulated in development, through negative allometry and posterior/medial displacement of ME bones relative to the jaw joint. Here we show, using µCT reconstructions, that neither allometric nor topological change is quantifiable in the pre-detachment ME development of six marsupials and two monotremes. Also, differential ME positioning in the two monotreme species is not recapitulated. This challenges the developmental prerequisites of widely cited evolutionary scenarios of definitive mammalian middle ear (DMME) evolution, highlighting the requirement for further fossil evidence to test these hypotheses. Possible association between rear molar eruption, full ME ossification and ME detachment in marsupials suggests functional divergence between dentary and ME as a trigger for developmental, and possibly also evolutionary, ME detachment. The stable positioning of the dentary and ME supports suggestions that a 'partial mammalian middle ear' as found in many mammaliaforms--probably with a cartilaginous Meckel's cartilage--represents the only developmentally plausible evolutionary DMME precursor. PMID:26763693
... eyesight if not treated. If both eyes are black after a head injury, it could signify a skull fracture or other serious injury. Next Black Eye Symptoms Related Ask an Ophthalmologist Answers How ...
... diuretic to increase urine flow. Some people use black tea for preventing tooth decay and kidney stones. In combination with various other products, black tea is used for weight loss. In foods, ...
Jackalina M Van Kampen
Full Text Available The development of effective neuroprotective therapies for Parkinson's disease (PD has been severely hindered by the notable lack of an appropriate animal model for preclinical screening. Indeed, most models currently available are either acute in nature or fail to recapitulate all characteristic features of the disease. Here, we present a novel progressive model of PD, with behavioural and cellular features that closely approximate those observed in patients. Chronic exposure to dietary phytosterol glucosides has been found to be neurotoxic. When fed to rats, β-sitosterol β-d-glucoside (BSSG triggers the progressive development of parkinsonism, with clinical signs and histopathology beginning to appear following cessation of exposure to the neurotoxic insult and continuing to develop over several months. Here, we characterize the progressive nature of this model, its non-motor features, the anatomical spread of synucleinopathy, and response to levodopa administration. In Sprague Dawley rats, chronic BSSG feeding for 4 months triggered the progressive development of a parkinsonian phenotype and pathological events that evolved slowly over time, with neuronal loss beginning only after toxin exposure was terminated. At approximately 3 months following initiation of BSSG exposure, animals displayed the early emergence of an olfactory deficit, in the absence of significant dopaminergic nigral cell loss or locomotor deficits. Locomotor deficits developed gradually over time, initially appearing as locomotor asymmetry and developing into akinesia/bradykinesia, which was reversed by levodopa treatment. Late-stage cognitive impairment was observed in the form of spatial working memory deficits, as assessed by the radial arm maze. In addition to the progressive loss of TH+ cells in the substantia nigra, the appearance of proteinase K-resistant intracellular α-synuclein aggregates was also observed to develop progressively, appearing first in the
Luminet, Jean-Pierre
1992-09-01
Foreword to the French edition; Foreword to the English edition; Acknowledgements; Part I. Gravitation and Light: 1. First fruits; 2. Relativity; 3. Curved space-time; Part II. Exquisite Corpses: 4. Chronicle of the twilight years; 5. Ashes and diamonds; 6. Supernovae; 7. Pulsars; 8. Gravitation triumphant; Part III. Light Assassinated: 9. The far horizon; 10. Illuminations; 11. A descent into the maelstrom; 12. Map games; 13. The black hole machine; 14. The quantum black hole; Part IV. Light Regained: 15. Primordial black holes; 16. The zoo of X-ray stars; 17. Giant black holes; 18. Gravitational light; 19. The black hole Universe; Appendices; Bibliography; Name index; Subject index.
Angela Khristin Brown
2013-07-01
Full Text Available The migration of blacks in North America through slavery became united. The population of blacks past downs a tradition of artist through art to native born citizens. The art tradition involved telling stories to each generation in black families. The black culture elevated by tradition created hope to determine their personal freedom to escape from poverty of enslavement and to establish a way of life through tradition. A way of personal freedoms was through getting a good education that lead to a better foundation and a better way of life.
Nigim, Fares; Cavanaugh, Jill; Patel, Anoop P; Curry, William T; Esaki, Shin-ichi; Kasper, Ekkehard M; Chi, Andrew S; Louis, David N; Martuza, Robert L; Rabkin, Samuel D; Wakimoto, Hiroaki
2015-07-01
Tissue hypoxia and necrosis represent pathophysiologic and histologic hallmarks of glioblastoma (GBM). Although hypoxia inducible factor 1α (HIF-1α) plays crucial roles in the malignant phenotypes of GBM, developing HIF-1α-targeted agents has been hampered by the lack of a suitable preclinical model that recapitulates the complex biology of clinical GBM. We present a new GBM model, MGG123, which was established from a recurrent human GBM. Orthotopic xenografting of stem-like MGG123 cells reproducibly generated lethal tumors that were characterized by foci of palisading necrosis, hypervascularity, and robust stem cell marker expression. Perinecrotic neoplastic cells distinctively express HIF-1α and are proliferative in both xenografts and the patient tissue. The xenografts contain scattered hypoxic foci that were consistently greater than 50 μm distant from blood vessels, indicating intratumoral heterogeneity of oxygenation. Hypoxia enhanced HIF-1α expression in cultured MGG123 cells, which was abrogated by the HIF-1α inhibitors digoxin or ouabain. In vivo, treatment of orthotopic MGG123 xenografts with digoxin decreased HIF-1α expression, vascular endothelial growth factor mRNA levels, and CD34-positive vasculature within the tumors, and extended survival of mice bearing the aggressive MGG123 GBM. This preclinical tumor model faithfully recapitulates the GBM-relevant hypoxic microenvironment and stemness and is a suitable platform for studying disease biology and developing hypoxia-targeted agents. PMID:26083570
Raja, Waseem K; Mungenast, Alison E; Lin, Yuan-Ta; Ko, Tak; Abdurrob, Fatema; Seo, Jinsoo; Tsai, Li-Huei
2016-01-01
The dismal success rate of clinical trials for Alzheimer's disease (AD) motivates us to develop model systems of AD pathology that have higher predictive validity. The advent of induced pluripotent stem cells (iPSCs) allows us to model pathology and study disease mechanisms directly in human neural cells from healthy individual as well as AD patients. However, two-dimensional culture systems do not recapitulate the complexity of neural tissue, and phenotypes such as extracellular protein aggregation are difficult to observe. We report brain organoids that use pluripotent stem cells derived from AD patients and recapitulate AD-like pathologies such as amyloid aggregation, hyperphosphorylated tau protein, and endosome abnormalities. These pathologies are observed in an age-dependent manner in organoids derived from multiple familial AD (fAD) patients harboring amyloid precursor protein (APP) duplication or presenilin1 (PSEN1) mutation, compared to controls. The incidence of AD pathology was consistent amongst several fAD lines, which carried different mutations. Although these are complex assemblies of neural tissue, they are also highly amenable to experimental manipulation. We find that treatment of patient-derived organoids with β- and γ-secretase inhibitors significantly reduces amyloid and tau pathology. Moreover, these results show the potential of this model system to greatly increase the translatability of pre-clinical drug discovery in AD. PMID:27622770
Are black holes totally black?
Grib, A A
2014-01-01
Geodesic completeness needs existence near the horizon of the black hole of "white hole" geodesics coming from the region inside of the horizon. Here we give the classification of all such geodesics with the energies $E/m \\le 1$ for the Schwarzschild and Kerr's black hole. The collisions of particles moving along the "white hole" geodesics with those moving along "black hole" geodesics are considered. Formulas for the increase of the energy of collision in the centre of mass frame are obtained and the possibility of observation of high energy particles arriving from the black hole to the Earth is discussed.
One way for states and subnational groups to acquire material, knowledge and equipment necessary to build a nuclear weapon or device are illegal transactions. These were singular in the past and did not cause the development of a nuclear black market. But all necessary components of a functioning black market exist. Therefore the further spread and extension of the use of nuclear power would enhance the threat of a nuclear black market, if the trade and use of specific nuclear material is not abandoned worldwide. (orig.)
... product containing black tea extract plus green tea extract, asparagus, guarana, kidney bean, and mate along with a combination of kidney bean pods, garcinia, and chromium yeast for 12 weeks does not reduce body weight ...
Robert C. Merton; Myron S. Scholes
2013-01-01
ReprintThis article was originally published by Wiley for the American Finance Association (Merton RC, Scholes MS. 1995. Fischer Black. J. Finance 50(5):1359–70). It is reprinted with permission from John Wiley and Sons © 1995. Reference formatting was updated to facilitate linking.
Umemura, Yasuhiro; Yoshida, Junko; Wada, Masashi; Tsuchiya, Yoshiki; Minami, Yoichi; Watanabe, Hitomi; Kondoh, Gen; Takeda, Junji; Inokawa, Hitoshi; Horie, Kyoji; Yagita, Kazuhiro
2013-01-01
We previously reported emergence and disappearance of circadian molecular oscillations during differentiation of mouse embryonic stem (ES) cells and reprogramming of differentiated cells, respectively. Here we present a robust and stringent in vitro circadian clock formation assay that recapitulates in vivo circadian phenotypes. This assay system first confirmed that a mutant ES cell line lacking Casein Kinase I delta (CKIδ) induced ∼3 hours longer period-length of circadian rhythm than the wild type, which was compatible with recently reported results using CKIδ null mice. In addition, this assay system also revealed that a Casein Kinase 2 alpha subunit (CK2α) homozygous mutant ES cell line developed significantly longer (about 2.5 hours) periods of circadian clock oscillations after in vitro or in vivo differentiation. Moreover, revertant ES cell lines in which mutagenic vector sequences were deleted showed nearly wild type periods after differentiation, indicating that the abnormal circadian period of the mutant ES cell line originated from the mutation in the CK2α gene. Since CK2α deficient mice are embryonic lethal, this in vitro assay system represents the genetic evidence showing an essential role of CK2α in the mammalian circadian clock. This assay was successfully applied for the phenotype analysis of homozygous mutant ES cells, demonstrating that an ES cell-based in vitro assay is available for circadian genetic screening. PMID:23840637
Mannino, Robert G.; Myers, David R.; Ahn, Byungwook; Wang, Yichen; Margo Rollins; Gole, Hope; Lin, Angela S.; Guldberg, Robert E.; Giddens, Don P.; Timmins, Lucas H.; Lam, Wilbur A.
2015-07-01
Investigating biophysical cellular interactions in the circulation currently requires choosing between in vivo models, which are difficult to interpret due in part to the hemodynamic and geometric complexities of the vasculature; or in vitro systems, which suffer from non-physiologic assumptions and/or require specialized microfabrication facilities and expertise. To bridge that gap, we developed an in vitro “do-it-yourself” perfusable vasculature model that recapitulates in vivo geometries, such as aneurysms, stenoses, and bifurcations, and supports endothelial cell culture. These inexpensive, disposable devices can be created rapidly (<2 hours) with high precision and repeatability, using standard off-the-shelf laboratory supplies. Using these “endothelialized” systems, we demonstrate that spatial variation in vascular cell adhesion molecule (VCAM-1) expression correlates with the wall shear stress patterns of vascular geometries. We further observe that the presence of endothelial cells in stenoses reduces platelet adhesion but increases sickle cell disease (SCD) red blood cell (RBC) adhesion in bifurcations. Overall, our method enables researchers from all disciplines to study cellular interactions in physiologically relevant, yet simple-to-make, in vitro vasculature models.
Han, Bumsoo; Qu, Chunjing; Park, Kinam; Konieczny, Stephen F; Korc, Murray
2016-09-28
Targeted delivery aims to selectively distribute drugs to targeted tumor tissues but not to healthy tissues. This can address many clinical challenges by maximizing the efficacy but minimizing the toxicity of anti-cancer drugs. However, a complex tumor microenvironment poses various barriers hindering the transport of drugs and drug delivery systems. New tumor models that allow for the systematic study of these complex environments are highly desired to provide reliable test beds to develop drug delivery systems for targeted delivery. Recently, research efforts have yielded new in vitro tumor models, the so called tumor-microenvironment-on-chip, that recapitulate certain characteristics of the tumor microenvironment. These new models show benefits over other conventional tumor models, and have the potential to accelerate drug discovery and enable precision medicine. However, further research is warranted to overcome their limitations and to properly interpret the data obtained from these models. In this article, key features of the in vivo tumor microenvironment that are relevant to drug transport processes for targeted delivery were discussed, and the current status and challenges for developing in vitro transport model systems were reviewed. PMID:26688098
Xiang Li
Full Text Available Microfluidic technologies enable in vitro studies to closely simulate in vivo microvessel environment with complexity. Such method overcomes certain constrains of the statically cultured endothelial monolayers and enables the cells grow under physiological range of shear flow with geometry similar to microvessels in vivo. However, there are still existing knowledge gaps and lack of convincing evidence to demonstrate and quantify key biological features of the microfluidic microvessels. In this paper, using advanced micromanufacturing and microfluidic technologies, we presented an engineered microvessel model that mimicked the dimensions and network structures of in vivo microvessels with a long-term and continuous perfusion capability, as well as high-resolution and real-time imaging capability. Through direct comparisons with studies conducted in intact microvessels, our results demonstrated that the cultured microvessels formed under perfused conditions recapitulated certain key features of the microvessels in vivo. In particular, primary human umbilical vein endothelial cells were successfully cultured the entire inner surfaces of the microchannel network with well-developed junctions indicated by VE-cadherin staining. The morphological and proliferative responses of endothelial cells to shear stresses were quantified under different flow conditions which was simulated with three-dimensional shear dependent numerical flow model. Furthermore, we successfully measured agonist-induced changes in intracellular Ca2+ concentration and nitric oxide production at individual endothelial cell levels using fluorescence imaging. The results were comparable to those derived from individually perfused intact venules. With in vivo validation of its functionalities, our microfluidic model demonstrates a great potential for biological applications and bridges the gaps between in vitro and in vivo microvascular research.
Ahrends, Tomasz; Bąbała, Nikolina; Xiao, Yanling; Yagita, Hideo; van Eenennaam, Hans; Borst, Jannie
2016-05-15
While showing promise, vaccination strategies to treat cancer require further optimization. Likely barriers to efficacy involve cancer-associated immunosuppression and peripheral tolerance, which limit the generation of effective vaccine-specific cytotoxic T lymphocytes (CTL). Because CD4(+) T cells improve CTL responsiveness, next-generation vaccines include helper epitopes. Here, we demonstrate in mice how CD4(+) T-cell help optimizes the CTL response to a clinically relevant DNA vaccine engineered to combat human papillomavirus-expressing tumors. Inclusion of tumor-unrelated helper epitopes greatly increased CTL priming, effector, and memory T-cell programming. CD4(+) T-cell help optimized the CTL response in all these aspects via CD27/CD70 costimulation. Notably, administration of an agonistic CD27 antibody could largely replace helper epitopes in promoting primary and memory CTL responses, acting directly on CD8(+) T cells. CD27 agonism improved efficacy of the vaccine without helper epitopes, more so than combined PD-1 and CTLA-4 blockade. Combining CD27 agonism with CTLA-4 blockade improved vaccine-induced CTL priming and tumor infiltration, but only combination with PD-1 blockade was effective at eradicating tumors, thereby fully recapitulating the effect of CD4(+) T-cell help on vaccine efficacy. PD-1 blockade alone did not affect CTL priming or tumor infiltration, so these results implied that it cooperated with CD4(+) T-cell help by alleviating immune suppression against CTL in the tumor. Helper epitope inclusion or CD27 agonism did not stimulate regulatory T cells, and vaccine efficacy was also improved by CD27 agonism in the presence of CD4(+) T-cell help. Our findings provide a preclinical rationale to apply CD27 agonist antibodies, either alone or combined with PD-1 blockade, to improve the therapeutic efficacy of cancer vaccines and immunotherapy generally. Cancer Res; 76(10); 2921-31. ©2016 AACR. PMID:27020860
Nader Al Nakouzi
2012-05-01
Full Text Available Bone metastases have a devastating impact on quality of life and bone pain in patients with prostate cancer and decrease survival. Animal models are important tools in investigating the pathogenesis of the disease and in developing treatment strategies for bone metastases, but few animal models recapitulate spontaneous clinical bone metastatic spread. In the present study, IGR-CaP1, a new cell line derived from primary prostate cancer, was stably transduced with a luciferase-expressing viral vector to monitor tumor growth in mice using bioluminescence imaging. The IGR-CaP1 tumors grew when subcutaneously injected or when orthotopically implanted, reconstituted the prostate adenocarcinoma with glandular acini-like structures, and could disseminate to the liver and lung. Bone lesions were detected using bioluminescence imaging after direct intratibial or intracardiac injections. Anatomic bone structure assessed using high-resolution computed tomographic scans showed both lytic and osteoblastic lesions. Technetium Tc 99m methylene diphosphonate micro single-photon emission computed tomography confirmed the mixed nature of the lesions and the intensive bone remodeling. We also identified an expression signature for responsiveness of IGR-CaP1 cells to the bone microenvironment, namely expression of CXCR4, MMP-9, Runx2, osteopontin, osteoprotegerin, ADAMTS14, FGFBP2, and HBB. The IGR-CaP1 cell line is a unique model derived from a primary tumor, which can reconstitute human prostate adenocarcinoma in animals and generate experimental bone metastases, providing a novel means for understanding the mechanisms of bone metastasis progression and allowing preclinical testing of new therapies.
Kristin A. Gabor
2014-11-01
Full Text Available Seasonal influenza virus infections cause annual epidemics and sporadic pandemics. These present a global health concern, resulting in substantial morbidity, mortality and economic burdens. Prevention and treatment of influenza illness is difficult due to the high mutation rate of the virus, the emergence of new virus strains and increasing antiviral resistance. Animal models of influenza infection are crucial to our gaining a better understanding of the pathogenesis of and host response to influenza infection, and for screening antiviral compounds. However, the current animal models used for influenza research are not amenable to visualization of host-pathogen interactions or high-throughput drug screening. The zebrafish is widely recognized as a valuable model system for infectious disease research and therapeutic drug testing. Here, we describe a zebrafish model for human influenza A virus (IAV infection and show that zebrafish embryos are susceptible to challenge with both influenza A strains APR8 and X-31 (Aichi. Influenza-infected zebrafish show an increase in viral burden and mortality over time. The expression of innate antiviral genes, the gross pathology and the histopathology in infected zebrafish recapitulate clinical symptoms of influenza infections in humans. This is the first time that zebrafish embryos have been infected with a fluorescent IAV in order to visualize infection in a live vertebrate host, revealing a pattern of vascular endothelial infection. Treatment of infected zebrafish with a known anti-influenza compound, Zanamivir, reduced mortality and the expression of a fluorescent viral gene product, demonstrating the validity of this model to screen for potential antiviral drugs. The zebrafish model system has provided invaluable insights into host-pathogen interactions for a range of infectious diseases. Here, we demonstrate a novel use of this species for IAV research. This model has great potential to advance our
Gabor, Kristin A; Goody, Michelle F; Mowel, Walter K; Breitbach, Meghan E; Gratacap, Remi L; Witten, P Eckhard; Kim, Carol H
2014-11-01
Seasonal influenza virus infections cause annual epidemics and sporadic pandemics. These present a global health concern, resulting in substantial morbidity, mortality and economic burdens. Prevention and treatment of influenza illness is difficult due to the high mutation rate of the virus, the emergence of new virus strains and increasing antiviral resistance. Animal models of influenza infection are crucial to our gaining a better understanding of the pathogenesis of and host response to influenza infection, and for screening antiviral compounds. However, the current animal models used for influenza research are not amenable to visualization of host-pathogen interactions or high-throughput drug screening. The zebrafish is widely recognized as a valuable model system for infectious disease research and therapeutic drug testing. Here, we describe a zebrafish model for human influenza A virus (IAV) infection and show that zebrafish embryos are susceptible to challenge with both influenza A strains APR8 and X-31 (Aichi). Influenza-infected zebrafish show an increase in viral burden and mortality over time. The expression of innate antiviral genes, the gross pathology and the histopathology in infected zebrafish recapitulate clinical symptoms of influenza infections in humans. This is the first time that zebrafish embryos have been infected with a fluorescent IAV in order to visualize infection in a live vertebrate host, revealing a pattern of vascular endothelial infection. Treatment of infected zebrafish with a known anti-influenza compound, Zanamivir, reduced mortality and the expression of a fluorescent viral gene product, demonstrating the validity of this model to screen for potential antiviral drugs. The zebrafish model system has provided invaluable insights into host-pathogen interactions for a range of infectious diseases. Here, we demonstrate a novel use of this species for IAV research. This model has great potential to advance our understanding of
Elliot, Michael G; Crespi, Bernard J
2015-03-01
The relationship between phenotypic variation arising through individual development and phenotypic variation arising through diversification of species has long been a central question in evolutionary biology. Among humans, reduced placental invasion into endometrial tissues is associated with diseases of pregnancy, especially pre-eclampsia, and reduced placental invasiveness has also evolved, convergently, in at least 10 lineages of eutherian mammals. We tested the hypothesis that a common genetic basis underlies both reduced placental invasion arising through a developmental process in human placental disease and reduced placental invasion found as a derived trait in the diversification of Euarchontoglires (rodents, lagomorphs, tree shrews, colugos and primates). Based on whole-genome analyses across 18 taxa, we identified 1254 genes as having evolved adaptively across all three lineages exhibiting independent evolutionary transitions towards reduced placental invasion. These genes showed strong evidence of enrichment for associations with pre-eclampsia, based on genetic-association studies, gene-expression analyses and gene ontology. We further used in silico prediction to identify a subset of 199 genes that are likely targets of natural selection during transitions in placental invasiveness and which are predicted to also underlie human placental disorders. Our results indicate that abnormal ontogenies can recapitulate major phylogenetic shifts in mammalian evolution, identify new candidate genes for involvement in pre-eclampsia, imply that study of species with less-invasive placentation will provide useful insights into the regulation of placental invasion and pre-eclampsia, and recommend a novel comparative functional-evolutionary approach to the study of genetically based human disease and mammalian diversification. PMID:25602073
Allison, Andrew B; Kohler, Dennis J; Ortega, Alicia; Hoover, Elizabeth A; Grove, Daniel M; Holmes, Edward C; Parrish, Colin R
2014-11-01
Canine parvovirus (CPV) emerged as a new pandemic pathogen of dogs in the 1970s and is closely related to feline panleukopenia virus (FPV), a parvovirus of cats and related carnivores. Although both viruses have wide host ranges, analysis of viral sequences recovered from different wild carnivore species, as shown here, demonstrated that>95% were derived from CPV-like viruses, suggesting that CPV is dominant in sylvatic cycles. Many viral sequences showed host-specific mutations in their capsid proteins, which were often close to sites known to control binding to the transferrin receptor (TfR), the host receptor for these carnivore parvoviruses, and which exhibited frequent parallel evolution. To further examine the process of host adaptation, we passaged parvoviruses with alternative backgrounds in cells from different carnivore hosts. Specific mutations were selected in several viruses and these differed depending on both the background of the virus and the host cells in which they were passaged. Strikingly, these in vitro mutations recapitulated many specific changes seen in viruses from natural populations, strongly suggesting they are host adaptive, and which were shown to result in fitness advantages over their parental virus. Comparison of the sequences of the transferrin receptors of the different carnivore species demonstrated that many mutations occurred in and around the apical domain where the virus binds, indicating that viral variants were likely selected through their fit to receptor structures. Some of the viruses accumulated high levels of variation upon passage in alternative hosts, while others could infect multiple different hosts with no or only a few additional mutations. Overall, these studies demonstrate that the evolutionary history of a virus, including how long it has been circulating and in which hosts, as well as its phylogenetic background, has a profound effect on determining viral host range. PMID:25375184
Verbeeck Christophe
2012-10-01
Full Text Available Abstract Background Mutations in the gene encoding the RNA-binding protein fused in sarcoma (FUS can cause familial and sporadic amyotrophic lateral sclerosis (ALS and rarely frontotemproal dementia (FTD. FUS accumulates in neuronal cytoplasmic inclusions (NCIs in ALS patients with FUS mutations. FUS is also a major pathologic marker for a group of less common forms of frontotemporal lobar degeneration (FTLD, which includes atypical FTLD with ubiquitinated inclusions (aFTLD-U, neuronal intermediate filament inclusion disease (NIFID and basophilic inclusion body disease (BIBD. These diseases are now called FUS proteinopathies, because they share this disease marker. It is unknown how FUS mutations cause disease and the role of FUS in FTD-FUS cases, which do not have FUS mutations. In this paper we report the development of somatic brain transgenic (SBT mice using recombinant adeno-associated virus (rAAV to investigate how FUS mutations lead to neurodegeneration. Results We compared SBT mice expressing wild-type human FUS (FUSWT, and two ALS-linked mutations: FUSR521C and FUSΔ14, which lacks the nuclear localization signal. Both FUS mutants accumulated in the cytoplasm relative to FUSWT. The degree of this shift correlated with the severity of the FUS mutation as reflected by disease onset in humans. Mice expressing the most aggressive mutation, FUSΔ14, recapitulated many aspects of FUS proteinopathies, including insoluble FUS, basophilic and eosiniphilic NCIs, and other pathologic markers, including ubiquitin, p62/SQSTM1, α-internexin, and the poly-adenylate(A-binding protein 1 (PABP-1. However, TDP-43 did not localize to inclusions. Conclusions Our data supports the hypothesis that ALS or FTD-linked FUS mutations cause neurodegeneration by increasing cyotplasmic FUS. Accumulation of FUS in the cytoplasm may retain RNA targets and recruit additional RNA-binding proteins, such as PABP-1, into stress-granule like aggregates that coalesce into
Radionic nonuniform black strings
Tamaki, Takashi; Kanno, Sugumi; Soda, Jiro
2004-01-01
Nonuniform black strings in the two-brane system are investigated using the effective action approach. It is shown that the radion acts as a nontrivial hair of the black strings. From the brane point of view, the black string appears as the deformed dilatonic black hole which becomes a dilatonic black hole in the single brane limit and reduces to the Reissner-Nordström black hole in the close limit of two-branes. The stability of solutions is demonstrated using catastrophe theory. From the bulk point of view, the black strings are proved to be nonuniform. Nevertheless, the zeroth law of black hole thermodynamics still holds.
Black Silicon Solar Cells with Black Ribbons
Davidsen, Rasmus Schmidt; Tang, Peter Torben; Mizushima, Io;
2016-01-01
We present the combination of mask-less reactive ion etch (RIE) texturing and blackened interconnecting ribbons as a method for obtaining all-black solar panels, while using conventional, front-contacted solar cells. Black silicon made by mask-less reactive ion etching has total, average...... range 15.7-16.3%. The KOH-textured reference cell had an efficiency of 17.9%. The combination of black Si and black interconnecting ribbons may result in aesthetic, all-black panels based on conventional, front-contacted silicon solar cells....... reflectance below 0.5% across a 156x156 mm2 silicon (Si) wafer. Black interconnecting ribbons were realized by oxidizing copper resulting in reflectance below 3% in the visible wavelength range. Screen-printed Si solar cells were realized on 156x156 mm2 black Si substrates with resulting efficiencies in the...
We study noncommutative black holes, by using a diffeomorphism between the Schwarzschild black hole and the Kantowski-Sachs cosmological model, which is generalized to noncommutative minisuperspace. Through the use of the Feynman-Hibbs procedure we are able to study the thermodynamics of the black hole, in particular, we calculate Hawking's temperature and entropy for the 'noncommutative' Schwarzschild black hole
Black Entrepreneurship in America.
Green, Shelley; Pryde, Paul
The economic condition of black Americans is discussed, proceeding from the assumption that black economic progress does not depend on a renewed struggle for unobtained civil rights, but rather on the creative response of black Americans to economic opportunity and problems. In the long run, black economic development must rely on the…
Swathi Balaji
Full Text Available Mid-gestation fetal cutaneous wounds heal scarlessly and this has been attributed in part to abundant hyaluronan (HA in the extracellular matrix (ECM and a unique fibroblast phenotype. We recently reported a novel role for interleukin 10 (IL-10 as a regulator of HA synthesis in the fetal ECM, as well as the ability of the fetal fibroblast to produce an HA-rich pericellular matrix (PCM. We hypothesized that IL-10-mediated HA synthesis was essential to the fetal fibroblast functional phenotype and, moreover, that this phenotype could be recapitulated in adult fibroblasts via supplementation with IL-10 via an HA dependent process.To evaluate the differences in functional profile, we compared metabolism (MTS assay, apoptosis (caspase-3 staining, migration (scratch wound assay and invasion (transwell assay between C57Bl/6J murine fetal (E14.5 and adult (8 weeks fibroblasts. We found that fetal fibroblasts have lower rates of metabolism and apoptosis, and an increased ability to migrate and invade compared to adult fibroblasts, and that these effects were dependent on IL-10 and HA synthase activity. Further, addition of IL-10 to adult fibroblasts resulted in increased fibroblast migration and invasion and recapitulated the fetal phenotype in an HA-dependent manner.Our data demonstrates the functional differences between fetal and adult fibroblasts, and that IL-10 mediated HA synthesis is essential for the fetal fibroblasts' enhanced invasion and migration properties. Moreover, IL-10 via an HA-dependent mechanism can recapitulate this aspect of the fetal phenotype in adult fibroblasts, suggesting a novel mechanism of IL-10 in regenerative wound healing.
Xu, M; Li, L; Pittenger, C
2016-06-01
Tic disorders, including Tourette syndrome (TS), are thought to involve pathology of cortico-basal ganglia loops, but their pathology is not well understood. Post-mortem studies have shown a reduced number of several populations of striatal interneurons, including the parvalbumin-expressing fast-spiking interneurons (FSIs), in individuals with severe, refractory TS. We tested the causal role of this interneuronal deficit by recapitulating it in an otherwise normal adult mouse using a combination transgenic-viral cell ablation approach. FSIs were reduced bilaterally by ∼40%, paralleling the deficit found post-mortem. This did not produce spontaneous stereotypies or tic-like movements, but there was increased stereotypic grooming after acute stress in two validated paradigms. Stereotypy after amphetamine, in contrast, was not elevated. FSI ablation also led to increased anxiety-like behavior in the elevated plus maze, but not to alterations in motor learning on the rotorod or to alterations in prepulse inhibition, a measure of sensorimotor gating. These findings indicate that a striatal FSI deficit can produce stress-triggered repetitive movements and anxiety. These repetitive movements may recapitulate aspects of the pathophysiology of tic disorders. PMID:26968763
Long, Richard A.
1970-01-01
Indicates tendencies dangerous to the basic purpose of Black Studies, and identifies four external challeges--imperialism, paternalism, nihilism, and materialism. An internal challenge is considered to be the use of European and Establishment constructs to analyze black reality. (DM)
Hayward, Sean A.
2008-01-01
This is a review of current theory of black-hole dynamics, concentrating on the framework in terms of trapping horizons. Summaries are given of the history, the classical theory of black holes, the defining ideas of dynamical black holes, the basic laws, conservation laws for energy and angular momentum, other physical quantities and the limit of local equilibrium. Some new material concerns how processes such as black-hole evaporation and coalescence might be described by a single trapping h...
Lopez-DomInguez, J C [Instituto de Fisica de la Universidad de Guanajuato PO Box E-143, 37150 Leoen Gto. (Mexico); Obregon, O [Instituto de Fisica de la Universidad de Guanajuato PO Box E-143, 37150 Leoen Gto. (Mexico); RamIrez, C [Facultad de Ciencias FIsico Matematicas, Universidad Autonoma de Puebla, PO Box 1364, 72000 Puebla (Mexico); Sabido, M [Instituto de Fisica de la Universidad de Guanajuato PO Box E-143, 37150 Leoen Gto. (Mexico)
2007-11-15
We study noncommutative black holes, by using a diffeomorphism between the Schwarzschild black hole and the Kantowski-Sachs cosmological model, which is generalized to noncommutative minisuperspace. Through the use of the Feynman-Hibbs procedure we are able to study the thermodynamics of the black hole, in particular, we calculate Hawking's temperature and entropy for the 'noncommutative' Schwarzschild black hole.
Strominger, Andrew
1993-01-01
The quantum statistics of charged, extremal black holes is investigated beginning with the hypothesis that the quantum state is a functional on the space of closed three-geometries, with each black hole connected to an oppositely charged black hole through a spatial wormhole. From this starting point a simple argument is given that a collection of extremal black holes obeys neither Bose nor Fermi statistics. Rather they obey an exotic variety of particle statistics known as ``infinite statist...
Gao, C. J.; Zhang, S. N.
2006-01-01
The exact solutions of electrically charged phantom black holes with the cosmological constant are constructed. They are labelled by the mass, the electrical charge, the cosmological constant and the coupling constant between the phantom and the Maxwell field. It is found that the phantom has important consequences on the properties of black holes. In particular, the extremal charged phantom black holes can never be achieved and so the third law of thermodynamics for black holes still holds. ...
Rector, Theresa A.
1982-01-01
Traces the contributions of Black Roman Catholic nuns to Black education in the United States since the early 1800s. Also shows that, despite declining membership, the three existing religious orders continue to be active in Black education and social change. (GC)
Black Holes in Higher Dimensions (Black Strings and Black Rings)
Kleihaus, Burkhard
2016-01-01
The last three years have again seen new exciting developments in the area of higher dimensional black objects. For black objects with noncompact higher dimensions, the solution space was exlored further within the blackfold approach and with numerical schemes, yielding a large variety of new families of solutions, while limiting procedures created so-called super-entropic black holes. Concerning compact extra dimensions, the sequences of static nonuniform black strings in five and six dimensions were extended to impressively large values of the nonuniformity parameter with extreme numerical precision, showing that an oscillating pattern arises for the mass, the area or the temperature, while approaching the conjectured double-cone merger solution. Besides the presentation of interesting new types of higherdimensional solutions, also their physical properties were addressed in this session. While the main focus was on Einstein gravity, a significant number of talks also covered Lovelock theories.
Del Bufalo, Francesca; Manzo, Teresa; Hoyos, Valentina; Yagyu, Shigeki; Caruana, Ignazio; Jacot, Jeffrey; Benavides, Omar; Rosen, Daniel; Brenner, Malcolm K
2016-04-01
Interactions between malignant and stromal cells and the 3D spatial architecture of the tumor both substantially modify tumor behavior, including the responses to small molecule drugs and biological therapies. Conventional 2D culture systems cannot replicate this complexity. To overcome these limitations and more accurately model solid tumors, we developed a highly versatile 3D PEG-fibrin hydrogel model of human lung adenocarcinoma. Our model relevantly recapitulates the effect of oncolytic adenovirus; tumor responses in this setting nearly reproduce those observed in vivo. We have also validated the use of this model for complex, long-term, 3D cultures of cancer cells and their stroma (fibroblasts and endothelial cells). Both tumor proliferation and invasiveness were enhanced in the presence of stromal components. These results validate our 3D hydrogel model as a relevant platform to study cancer biology and tumor responses to biological treatments. PMID:26826297
Nonstationary analogue black holes
We study the existence of analogue nonstationary spherically symmetric black holes. The prime example is the acoustic model see Unruh (1981 Phys. Rev. Lett. 46 1351). We consider also a more general class of metrics that could be useful in other physical models of analogue black and white holes. We give examples of the appearance of black holes and of disappearance of white holes. We also discuss the relation between the apparent and the event horizons for the case of analogue black holes. In the end we study the inverse problem of determination of black or white holes by boundary measurements for the spherically symmetric nonstationary metrics. (paper)
Levin, Janna; D'Orazio, Daniel
2016-03-01
Black holes are dark dead stars. Neutron stars are giant magnets. As the neutron star orbits the black hole, an electronic circuit forms that generates a blast of power just before the black hole absorbs the neutron star whole. The black hole battery conceivably would be observable at cosmological distances. Possible channels for luminosity include synchro-curvature radiation, a blazing fireball, or even an unstable, short-lived black hole pulsar. As suggested by Mingarelli, Levin, and Lazio, some fraction of the battery power could also be reprocessed into coherent radio emission to populate a subclass of fast radio bursts.
Alkac, Gokhan; Tekin, Bayram
2016-01-01
Asymptotically flat black holes in $2+1$ dimensions are a rarity. We study the recently found black flower solutions (asymptotically flat black holes with deformed horizons), static black holes, rotating black holes and the dynamical black flowers (black holes with radiative gravitons ) of the purely quadratic version of new massive gravity. We show how they appear in this theory and we also show that they are also solutions to the infinite order extended version of the new massive gravity, that is the Born-Infeld extension of new massive gravity with an amputated Einsteinian piece. The same metrics also solve the topologically extended versions of these theories, with modified conserved charges and the thermodynamical quantities, such as the Wald entropy. Besides these we find new conformally flat radiating type solutions to these extended gravity models. We also show that these metrics do not arise in Einstein's gravity coupled to physical perfect fluids.
Stimulated Black Hole Evaporation
Spaans, Marco
2016-01-01
Black holes are extreme expressions of gravity. Their existence is predicted by Einstein's theory of general relativity and is supported by observations. Black holes obey quantum mechanics and evaporate spontaneously. Here it is shown that a mass rate $R_f\\sim 3\\times 10^{-8} (M_0/M)^{1/2}$ $M_0$ yr$^{-1}$ onto the horizon of a black hole with mass $M$ (in units of solar mass $M_0$) stimulates a black hole into rapid evaporation. Specifically, $\\sim 3 M_0$ black holes can emit a large fraction of their mass, and explode, in $M/R_f \\sim 3\\times 10^7 (M/M_0)^{3/2}$ yr. These stimulated black holes radiate a spectral line power $P \\sim 2\\times 10^{39} (M_0/M)^{1/2}$ erg s$^{-1}$, at a wavelength $\\lambda \\sim 3\\times 10^5 (M/M_0)$ cm. This prediction can be observationally verified.
Gorini, Vittorio; Moschella, Ugo; Treves, Aldo; Colpi, Monica
2016-01-01
Based on graduate school lectures in contemporary relativity and gravitational physics, this book gives a complete and unified picture of the present status of theoretical and observational properties of astrophysical black holes. The chapters are written by internationally recognized specialists. They cover general theoretical aspects of black hole astrophysics, the theory of accretion and ejection of gas and jets, stellar-sized black holes observed in the Milky Way, the formation and evolution of supermassive black holes in galactic centers and quasars as well as their influence on the dynamics in galactic nuclei. The final chapter addresses analytical relativity of black holes supporting theoretical understanding of the coalescence of black holes as well as being of great relevance in identifying gravitational wave signals. With its introductory chapters the book is aimed at advanced graduate and post-graduate students, but it will also be useful for specialists.
Ahn, Eun-Joo; Cavaglia, Marco
2003-01-01
Production of high-energy gravitational objects is a common feature of gravitational theories. The primordial universe is a natural setting for the creation of black holes and other nonperturbative gravitational entities. Cosmic black holes can be used to probe physical properties of the very early universe which would usually require the knowledge of the theory of quantum gravity. They may be the only tool to explore thermalisation of the early universe. Whereas the creation of cosmic black ...
Lettman-Hicks, Sharon
2014-01-01
The New Black is a documentary that tells the story of how the African American community is grappling with the gay rights issue in light of the recent gay marriage movement and the fight over Civil Rights. The film documents activities, families and clergy on both sides of the campaign to legalize gay marriage and examines homophobia in the Black community's institutional pillar, the Black church, and reveals the Christian right wing's strategy of exploiting this phenomenon in order to pursu...
Black branes as piezoelectrics.
Armas, Jay; Gath, Jakob; Obers, Niels A
2012-12-14
We find a realization of linear electroelasticity theory in gravitational physics by uncovering a new response coefficient of charged black branes, exhibiting their piezoelectric behavior. Taking charged dilatonic black strings as an example and using the blackfold approach we measure their elastic and piezolectric moduli. We also use our results to draw predictions about the equilibrium condition of charged dilatonic black rings in dimensions higher than six. PMID:23368298
Meng Sun
2015-08-01
Full Text Available We give a general illumination of a rotating black string falling into a rotating horizon in dimension D=5. It is a configuration of one smooth intersection between these two objects when the spacetime is axisymmetric and in the limit that the thickness of the black hole is much larger than the thickness of the black string. Following this configuration, we further extend them to the rotating and charged flows.
Hod, Shahar
2015-01-01
The holographic principle has taught us that, as far as their entropy content is concerned, black holes in $(3+1)$-dimensional curved spacetimes behave as ordinary thermodynamic systems in flat $(2+1)$-dimensional spacetimes. In this essay we point out that the opposite behavior can also be observed in black-hole physics. To show this we study the quantum Hawking evaporation of near-extremal Reissner-Nordstr\\"om black holes. We first point out that the black-hole radiation spectrum departs from the familiar radiation spectrum of genuine $(3+1)$-dimensional perfect black-body emitters. In particular, the would be black-body thermal spectrum is distorted by the curvature potential which surrounds the black hole and effectively blocks the emission of low-energy quanta. Taking into account the energy-dependent gray-body factors which quantify the imprint of passage of the emitted radiation quanta through the black-hole curvature potential, we reveal that the $(3+1)$-dimensional black holes effectively behave as p...
Begelman, Mitchell C
2003-06-20
Black holes are common objects in the universe. Each galaxy contains large numbers-perhaps millions-of stellar-mass black holes, each the remnant of a massive star. In addition, nearly every galaxy contains a supermassive black hole at its center, with a mass ranging from millions to billions of solar masses. This review discusses the demographics of black holes, the ways in which they interact with their environment, factors that may regulate their formation and growth, and progress toward determining whether these objects really warp spacetime as predicted by the general theory of relativity. PMID:12817138
The quantum statistics of charged, extremal black holes is investigated beginning with the hypothesis that the quantum state is a functional on the space of closed three-geometries, with each black hole connected to an oppositely charged black hole through a spatial wormhole. From this starting point a simple argument is given that a collection of extremal black holes obeys neither Bose nor Fermi statistics. Rather, they obey an exotic variety of particle statistics known as ''infinite statistics'' which resembles that of distinguishable particles and is realized by a q deformation of the quantum commutation relations
Hajdukovic, D
2006-01-01
We speculate about impact of antigravity (i.e. gravitational repulsion between matter and antimatter) on the creation and emission of particles by a black hole. If antigravity is present a black hole made of matter may radiate particles as a black body, but this shouldn't be true for antiparticles. It may lead to radical change of radiation process predicted by Hawking and should be taken into account in preparation of the attempt to create and study mini black holes at CERN. Gravity, including antigravity is more than ever similar to electrodynamics and such similarity with a successfully quantized interaction may help in quantization of gravity.
Neves, J C S
2015-01-01
In this work, we have deformed regular black holes which possess a general mass term described by a function which generalizes the Bardeen and Hayward mass terms. Using linear constraints in the energy-momentum tensor, the solutions are either regular or singular. That is, with this approach, it is possible to generate singular black holes from regular black holes and vice versa. Moreover, contrary to the Bardeen and Hayward regular solutions, the regular deformed metrics may violate the weak energy condition despite the presence of the spherical symmetry. Some comments on accretion of deformed black holes in cosmological scenarios are made.
Ronay, Valerie; Attin, Thomas
2011-01-01
The purpose of this review was to summarise the fundamentals about black stain, its diagnosis and possible differential diagnoses as well as its microbiology and therapy. In addition, various studies investigating the relationship between black stain and dental caries are examined. Many studies report lower caries prevalence in children with black stain, but this finding could not be confirmed by all authors. Also, a negative relation between degree of staining and caries severity has been described. Reasons for these results are not yet clear but it was speculated that they are related to the specific oral microflora described in black stain-affected individuals. PMID:21594205
"Black Capitalism": Toward Controlled Development of Black America
Wright, Robert E.
1969-01-01
Argues in favor of the connotation of the term "Black capitalism as the accumulation of capital resources by the Black people in a collective fashion for the benefit of the masses of Black people. (RJ)
Belief in the existence of black holes is the ultimate act of faith for a physicist. First suggested by the English clergyman John Michell in the year 1784, the gravitational pull of a black hole is so strong that nothing - not even light - can escape. Gravity might be the weakest of the fundamental forces but black-hole physics is not for the faint-hearted. Black holes present obvious problems for would-be observers because they cannot, by definition, be seen with conventional telescopes - although before the end of the decade gravitational-wave detectors should be able to study collisions between black holes. Until then astronomers can only infer the existence of a black hole from its gravitational influence on other matter, or from the X-rays emitted by gas and dust as they are dragged into the black hole. However, once this material passes through the 'event horizon' that surrounds the black hole, we will never see it again - not even with X-ray specs. Despite these observational problems, most physicists and astronomers believe that black holes do exist. Small black holes a few kilometres across are thought to form when stars weighing more than about two solar masses collapse under the weight of their own gravity, while supermassive black holes weighing millions of solar masses appear to be present at the centre of most galaxies. Moreover, some brave physicists have proposed ways to make black holes - or at least event horizons - in the laboratory. The basic idea behind these 'artificial black holes' is not to compress a large amount of mass into a small volume, but to reduce the speed of light in a moving medium to less than the speed of the medium and so create an event horizon. The parallels with real black holes are not exact but the experiments could shed new light on a variety of phenomena. The first challenge, however, is to get money for the research. One year on from a high-profile meeting on artificial black holes in London, for instance, the UK
Rotating Brane World Black Holes
Modgil, Moninder Singh; Panda, Sukanta; Sengupta, Gautam
2001-01-01
A five dimensional rotating black string in a Randall-Sundrum brane world is considered. The black string intercepts the three brane in a four dimensional rotating black hole. The geodesic equations and the asymptotics in this background are discussed.
Evolution of massive black holes
Volonteri, Marta
2007-01-01
Supermassive black holes are nowadays believed to reside in most local galaxies. Accretion of gas and black hole mergers play a fundamental role in determining the two parameters defining a black hole: mass and spin. I briefly review here some of the physical processes that are conducive to the evolution of the massive black hole population. I'll discuss black hole formation processes that are likely to place at early cosmic epochs, and how massive black hole evolve in a hierarchical Universe...
Pyrolytic carbon coated black silicon
Shah, Ali; Stenberg, Petri; Karvonen, Lasse; Ali, Rizwan; Honkanen, Seppo; Lipsanen, Harri; Peyghambarian, N.; Kuittinen, Markku; Svirko, Yuri; Kaplas, Tommi
2016-01-01
Carbon is the most well-known black material in the history of man. Throughout the centuries, carbon has been used as a black material for paintings, camouflage, and optics. Although, the techniques to make other black surfaces have evolved and become more sophisticated with time, carbon still remains one of the best black materials. Another well-known black surface is black silicon, reflecting less than 0.5% of incident light in visible spectral range but becomes a highly reflecting surface ...
A process and apparatus for recovering carbon black from hot smoke which comprises passing the smoke through a cyclone separation zone following cooling, then through aggregate filter beds and regeneration of filter beds with clean off-gas which is recycled to the carbon black reaction zone as quench
Noncommutative Singular Black Holes
In this paper, applying the method of coordinate coherent states to describe a noncommutative model of Vaidya black holes leads to an exact (t - r) dependence of solution in terms of the noncommutative parameter σ. In this setup, there is no black hole remnant at long times.
Noncommutative Singular Black Holes
Hamid Mehdipour, S.
2010-11-01
In this paper, applying the method of coordinate coherent states to describe a noncommutative model of Vaidya black holes leads to an exact (t — r) dependence of solution in terms of the noncommutative parameter σ. In this setup, there is no black hole remnant at long times.
Kragh, Helge Stjernholm
2016-01-01
Review essay, Marcia Bartusiak, Black Hole: How an Idea Abandoned by Newtonians, Hated by Einstein, and Gambled On by Hawking Became Loved (New Haven: Yale University Press, 2015).......Review essay, Marcia Bartusiak, Black Hole: How an Idea Abandoned by Newtonians, Hated by Einstein, and Gambled On by Hawking Became Loved (New Haven: Yale University Press, 2015)....
Bousso, R.; Hawking, S. W.
1997-08-01
We summarise recent work on the quantum production of black holes in the inflationary era. We describe, in simple terms, the Euclidean approach used, and the results obtained both for the pair creation rate and for the evolution of the black holes.
Andersson, N
2000-01-01
This is a chapter on Black-hole Scattering that was commissioned for an Encyclopaedia on Scattering edited by Pike and Sabatier, to be published by Academic Press. The chapter surveys wave propagation in black-hole spacetimes, diffraction effects in wave scattering, resonances, quasinormal modes and related topics.
Black Craftsmen Through History.
Myers, Robin
This report traces the evolution of the black craftsmen from ancient Egypt to the present. Special attention is given to the restricted use of black craftsmen under slavery, and the added problems they faced after being freed. Business and union discimination is described, along with recent government and private efforts to achieve equal…
Koustubh Ajit Kabe
2012-09-01
In the following paper, certain black hole dynamic potentials have been developed definitively on the lines of classical thermodynamics. These potentials have been refined in view of the small differences in the equations of the laws of black hole dynamics as given by Bekenstein and those of thermodynamics. Nine fundamental black hole dynamical relations have been developed akin to the four fundamental thermodynamic relations of Maxwell. The specific heats , and , have been defined. For a black hole, these quantities are negative. The d equation has been obtained as an application of these fundamental relations. Time reversible processes observing constancy of surface gravity are considered and an equation connecting the internal energy of the black hole , the additional available energy defined as the first free energy function , and the surface gravity , has been obtained. Finally as a further application of the fundamental relations, it has been proved for a homogeneous gravitational field in black hole space times or a de Sitter black hole that $C_{\\Omega,\\Phi}-C_{J,Q}=\\kappa \\left[\\left(\\dfrac{\\partial J}{\\partial \\kappa}\\right)_{\\Omega,\\Phi}\\left(\\dfrac{\\partial \\Omega}{\\partial \\kappa}\\right)_{J,Q}+\\left(\\dfrac{\\partial Q}{\\partial \\kappa}\\right)_{\\Omega,\\Phi}\\left(\\dfrac{\\partial\\Phi}{\\partial \\kappa}\\right)_{J,Q}\\right]$. This is dubbed as the homogeneous fluid approximation in context of the black holes.
Fluctuating Black Hole Horizons
Mei, Jianwei
2013-01-01
In this paper we treat the black hole horizon as a physical boundary to the spacetime and study its dynamics following from the Gibbons-Hawking-York boundary term. Using the Kerr black hole as an example we derive an effective action that describes, in the large wave number limit, a massless Klein-Gordon field living on the average location of the boundary. Complete solutions can be found in the small rotation limit of the black hole. The formulation suggests that the boundary can be treated in the same way as any other matter contributions. In particular, the angular momentum of the boundary matches exactly with that of the black hole, suggesting an interesting possibility that all charges (including the entropy) of the black hole are carried by the boundary. Using this as input, we derive predictions on the Planck scale properties of the boundary.
Black Youth Unemployment and the Black Family.
Hoskins, Linus A.
This paper analyzes the results of a survey conducted to ascertain the attitudes of 400 employers, youth, and academic/community professionals in Los Angeles, Chicago and Washington, D.C., toward an approach to Black youth unemployment centered on the creation of jobs and training among minority businesses in selected metropolitan areas. Minority…
The Black Family in American Economy: Black Capitalism.
Ezeocha, Peter A.
Black capitalism that is well planned and run is a source of enumerable benefits to the American society in general and to blacks in particular. It generates opportunities for blacks to perform in occupations which for many years were closed to them. For hundreds of years blacks have been despised and often looked down upon on account of the fact…
On the Charter Question: Black Marxism and Black Nationalism
Stern, Mark; Hussain, Khuram
2015-01-01
This article brings two black intellectual traditions to bear on the question of charter schools: black Marxism and black nationalism. The authors examine the theoretical and rhetorical devices used to talk about charters schools by focusing on how notions of "black liberation" are deployed by the charter movement, and to what end. The…
ULTRAMASSIVE BLACK HOLE COALESCENCE
Although supermassive black holes (SMBHs) correlate well with their host galaxies, there is an emerging view that outliers exist. Henize 2-10, NGC 4889, and NGC 1277 are examples of SMBHs at least an order of magnitude more massive than their host galaxy suggests. The dynamical effects of such ultramassive central black holes is unclear. Here, we perform direct N-body simulations of mergers of galactic nuclei where one black hole is ultramassive to study the evolution of the remnant and the black hole dynamics in this extreme regime. We find that the merger remnant is axisymmetric near the center, while near the large SMBH influence radius, the galaxy is triaxial. The SMBH separation shrinks rapidly due to dynamical friction, and quickly forms a binary black hole; if we scale our model to the most massive estimate for the NGC 1277 black hole, for example, the timescale for the SMBH separation to shrink from nearly a kiloparsec to less than a parsec is roughly 10 Myr. By the time the SMBHs form a hard binary, gravitational wave emission dominates, and the black holes coalesce in a mere few Myr. Curiously, these extremely massive binaries appear to nearly bypass the three-body scattering evolutionary phase. Our study suggests that in this extreme case, SMBH coalescence is governed by dynamical friction followed nearly directly by gravitational wave emission, resulting in a rapid and efficient SMBH coalescence timescale. We discuss the implications for gravitational wave event rates and hypervelocity star production
Noncommutative Solitonic Black Hole
Chang-Young, Ee; Lee, Daeho; Lee, Youngone
2012-01-01
We investigate solitonic black hole solutions in three dimensional noncommutative spacetime. We do this in gravity with negative cosmological constant coupled to a scalar field using the Moyal product expanded up to first order in the noncommutativity parameter in the two noncommutative spatial directions. By numerical simulation we look for black hole solutions by increasing the non- commutativity parameter value starting from regular solutions with vanishing noncommutativity. We find that even a regular soliton solution in the commutative case becomes a black hole solution when the noncommutativity parameter reaches a certain value.
Hayward, Sean Alan
2013-01-01
Black holes, once just fascinating theoretical predictions of how gravity warps space-time according to Einstein's theory, are now generally accepted as astrophysical realities, formed by post-supernova collapse, or as supermassive black holes mysteriously found at the cores of most galaxies, powering active galactic nuclei, the most powerful objects in the universe. Theoretical understanding has progressed in recent decades with a wider realization that local concepts should characterize black holes, rather than the global concepts found in textbooks. In particular, notions such as trapping h
Kuchiev, M Yu
2003-01-01
Black holes are presumed to have an ideal ability to absorb and keep matter. Whatever comes close to the event horizon, a boundary separating the inside region of a black hole from the outside world, inevitably goes in and remains inside forever. This work shows, however, that quantum corrections make possible a surprising process, reflection: a particle can bounce back from the event horizon. For low energy particles this process is efficient, black holes behave not as holes, but as mirrors, which changes our perception of their physical nature. Possible ways for observations of the reflection and its relation to the Hawking radiation process are outlined.
In the presence of a complex scalar field scalar–tensor theory allows for scalarized rotating hairy black holes. We exhibit the domain of existence for these scalarized black holes, which is bounded by scalarized rotating boson stars and hairy black holes of General Relativity. We discuss the global properties of these solutions. Like their counterparts in general relativity, their angular momentum may exceed the Kerr bound, and their ergosurfaces may consist of a sphere and a ring, i.e., form an ergo-Saturn
Kleihaus, Burkhard, E-mail: b.kleihaus@uni-oldenburg.de [Institut für Physik, Universität Oldenburg, Postfach 2503, D-26111 Oldenburg (Germany); Kunz, Jutta [Institut für Physik, Universität Oldenburg, Postfach 2503, D-26111 Oldenburg (Germany); Yazadjiev, Stoytcho [Department of Theoretical Physics, Faculty of Physics, Sofia University, Sofia 1164 (Bulgaria)
2015-05-11
In the presence of a complex scalar field scalar–tensor theory allows for scalarized rotating hairy black holes. We exhibit the domain of existence for these scalarized black holes, which is bounded by scalarized rotating boson stars and hairy black holes of General Relativity. We discuss the global properties of these solutions. Like their counterparts in general relativity, their angular momentum may exceed the Kerr bound, and their ergosurfaces may consist of a sphere and a ring, i.e., form an ergo-Saturn.
Kleihaus, Burkhard; Yazadjiev, Stoytcho
2015-01-01
In the presence of a complex scalar field scalar-tensor theory allows for scalarized rotating hairy black holes. We exhibit the domain of existence for these scalarized black holes, which is bounded by scalarized rotating boson stars and ordinary hairy black holes. We discuss the global properties of these solutions. Like their counterparts in general relativity, their angular momentum may exceed the Kerr bound, and their ergosurfaces may consist of a sphere and a ring, i.e., form an ergo-Saturn.
On Noncommutative Black Holes Thermodynamics
Faizal, Mir; Ulhoa, S C
2015-01-01
In this paper, we will analyze noncommutative deformation of the Schwarzschild black holes and Kerr black holes. We will perform our analysis by relating the commutative and the noncommutative metrics using an Moyal product. We will also analyze the thermodynamics of these noncommutative black hole solutions. We will explicitly derive expression for the corrected entropy and temperature of these black hole solutions.
The Thermodynamics of Black Holes
Wald Robert M.
2001-01-01
Full Text Available We review the present status of black hole thermodynamics. Our review includes discussion of classical black hole thermodynamics, Hawking radiation from black holes, the generalized second law, and the issue of entropy bounds. A brief survey also is given of approaches to the calculation of black hole entropy. We conclude with a discussion of some unresolved open issues.
The Price of "Black Dominance."
Hoberman, John
2000-01-01
Discusses the harmful effects of stereotyping black males as athletes, noting that over-identification with athletes and the world of physical performance limits black children's development by discouraging academic achievement. Examines the negative influence of mass media focus on black athletes, rappers, and stylized ghetto blackness. Discusses…
The Thermodynamics of Black Holes
Wald Robert M.
1999-01-01
We review the present status of black hole thermodynamics. Our review includes discussion of classical black hole thermodynamics, Hawking radiation from black holes, the generalized second law, and the issue of entropy bounds. A brief survey also is given of approaches to the calculation of black hole entropy. We conclude with a discussion of some unresolved open issues.
Black Writers' Views of America.
Ladner, Joyce
1979-01-01
Black literature of the 1960s reflected protest and an affirmation of Black power and Black consciousness. The 1970s have produced a counterwave in which Blacks, in order to achieve literary and financial recognition, have begun to focus less on race and social criticism and more on conservative and narcissistic themes. (Author/EB)
Topics in black hole evaporation
Two major aspects of particle creation by gravitational fields of black holes are studied: the neutrino emission from rotating black holes; and interactions between scalar particles emitted by a black hole. Neutrino emission is investigated under three topics: The asymmetry of the angular dependence of neutrino emission from rotating black holes; the production of a local matter excess by rotating black holes in a baryon symmetric universe; and cosmological magnetic field generation by neutrinos from evaporating black holes. Finally the author studies the effects of interactions on the black hole evaporation process
Black Holes in Higher Dimensions
In four space-time dimensions black holes of Einstein-Maxwell theory satisfy a number of theorems. In more than four space-time dimensions, however, some of the properties of black holes can change. In particular, uniqueness of black holes no longer holds. In five and more dimensions black rings arise. Thus in a certain region of the phase diagram there are three black objects with the same global charges present. Here we discuss properties of higher-dimensional vacuum and charged black holes, which possess a spherical horizon topology, and of vacuum and charged black rings, which have a ringlike horizon topology
Stansfield, K H; Ruby, K N; Soares, B D; McGlothan, J L; Liu, X; Guilarte, T R
2015-01-01
Environmental factors have been associated with psychiatric disorders and recent epidemiological studies suggest an association between prenatal lead (Pb(2+)) exposure and schizophrenia (SZ). Pb(2+) is a potent antagonist of the N-methyl-D-aspartate receptor (NMDAR) and converging evidence indicates that NMDAR hypofunction has a key role in the pathophysiology of SZ. The glutamatergic hypothesis of SZ posits that NMDAR hypofunction results in the loss of parvalbumin (PV)-positive GABAergic interneurons (PVGI) in the brain. Loss of PVGI inhibitory control to pyramidal cells alters the excitatory drive to midbrain dopamine neurons increasing subcortical dopaminergic activity. We hypothesized that if Pb(2+) exposure in early life is an environmental risk factor for SZ, it should recapitulate the loss of PVGI and reproduce subcortical dopaminergic hyperactivity. We report that on postnatal day 50 (PN50), adolescence rats chronically exposed to Pb(2+) from gestation through adolescence exhibit loss of PVGI in SZ-relevant brain regions. PV and glutamic acid decarboxylase 67 kDa (GAD67) protein were significantly decreased in Pb(2+) exposed rats with no apparent change in calretinin or calbindin protein levels suggesting a selective effect on the PV phenotype of GABAergic interneurons. We also show that Pb(2+) animals exhibit a heightened locomotor response to cocaine and express significantly higher levels of dopamine metabolites and D2-dopamine receptors relative to controls indicative of subcortical dopaminergic hyperactivity. Our results show that developmental Pb(2+) exposure reproduces specific neuropathology and functional dopamine system changes present in SZ. We propose that exposure to environmental toxins that produce NMDAR hypofunction during critical periods of brain development may contribute significantly to the etiology of mental disorders. PMID:25756805
Sebastián D Calligaris
Full Text Available BACKGROUND/AIM: Hypercaloric diet ingestion and sedentary lifestyle result in obesity. Metabolic syndrome is a cluster of clinical features secondary to obesity, considered as a pre-diabetic condition and recognized as an independent risk factor for cardiovascular diseases. To better understand the relationship between obesity, metabolic syndrome and cardiovascular disease as well as for the development of novel therapeutic strategies, animal models that reproduce the etiology, course and outcomes of these pathologies are required. The aim of this work was to characterize the long-term effects of high-fat diet-induced obesity on the mice cardiovascular system, in order to make available a new animal model for diabetic cardiomyopathy. METHODS/RESULTS: Male C57BL/6 mice were fed with a standardized high-fat diet (obese or regular diet (normal for 16 months. Metabolic syndrome was evaluated testing plasma glucose, triglycerides, cholesterol, insulin, and glucose tolerance. Arterial pressure was measured using a sphygmomanometer (non invasive method and by hemodynamic parameters (invasive method. Cardiac anatomy was described based on echocardiography and histological studies. Cardiac function was assessed by cardiac catheterization under a stress test. Cardiac remodelling and metabolic biomarkers were assessed by RT-qPCR and immunoblotting. As of month eight, the obese mice were overweight, hyperglycaemic, insulin resistant, hyperinsulinemic and hypercholesterolemic. At month 16, they also presented normal arterial pressure but altered vascular reactivity (vasoconstriction, and cardiac contractility reserve reduction, heart mass increase, cardiomyocyte hypertrophy, cardiac fibrosis, and heart metabolic compensations. By contrast, the normal mice remained healthy throughout the study. CONCLUSIONS: Mice fed with a high-fat diet for prolonged time recapitulates the etiology, course and outcomes of the early phases of human diabetic cardiomyopathy.
Del Rio, Maria-Luisa; Fernandez-Renedo, Carlos; Chaloin, Olivier; Scheu, Stefanie; Pfeffer, Klaus; Shintani, Yasushi; Perez-Simon, Jose-Antonio; Schneider, Pascal; Rodriguez-Barbosa, Jose-Ignacio
2016-04-01
Tumor necrosis factor (TNF)/TNF receptor (TNFR) superfamily members play essential roles in the development of the different phases of the immune response. Mouse LIGHT (TNFSF14) is a type II transmembrane protein with a C-terminus extracellular TNF homology domain (THD) that assembles in homotrimers and regulates the course of the immune responses by signaling through 2 receptors, the herpes virus entry mediator (HVEM, TNFSFR14) and the lymphotoxin β receptor (LTβR, TNFSFR3). LIGHT is a membrane-bound protein transiently expressed on activated T cells, natural killer (NK) cells and immature dendritic cells that can be proteolytically cleaved by a metalloprotease and released to the extracellular milieu. The immunotherapeutic potential of LIGHT blockade was evaluated in vivo. Administration of an antagonist of LIGHT interaction with its receptors attenuated the course of graft-versus-host reaction and recapitulated the reduced cytotoxic activity of LIGHT-deficient T cells adoptively transferred into non-irradiated semiallogeneic recipients. The lack of LIGHT expression on donor T cells or blockade of LIGHT interaction with its receptors slowed down the rate of T cell proliferation and decreased the frequency of precursor alloreactive T cells, retarding T cell differentiation toward effector T cells. The blockade of LIGHT/LTβR/HVEM pathway was associated with delayed downregulation of interleukin-7Rα and delayed upregulation of inducible costimulatory molecule expression on donor alloreactive CD8 T cells that are typical features of impaired T cell differentiation. These results expose the relevance of LIGHT/LTβR/HVEM interaction for the potential therapeutic control of the allogeneic immune responses mediated by alloreactive CD8 T cells that can contribute to prolong allograft survival. PMID:26752542
Shenderov, Kevin; Barber, Daniel L; Mayer-Barber, Katrin D; Gurcha, Sudagar S; Jankovic, Dragana; Feng, Carl G; Oland, Sandy; Hieny, Sara; Caspar, Pat; Yamasaki, Sho; Lin, Xin; Ting, Jenny P-Y; Trinchieri, Giorgio; Besra, Gurdyal S; Cerundolo, Vincenzo; Sher, Alan
2013-06-01
Although adjuvants are critical vaccine components, their modes of action are poorly understood. In this study, we investigated the mechanisms by which the heat-killed mycobacteria in CFA promote Th17 CD4(+) T cell responses. We found that IL-17 secretion by CD4(+) T cells following CFA immunization requires MyD88 and IL-1β/IL-1R signaling. Through measurement of Ag-specific responses after adoptive transfer of OTII cells, we confirmed that MyD88-dependent signaling controls Th17 differentiation rather than simply production of IL-17. Additional experiments showed that CFA-induced Th17 differentiation involves IL-1β processing by the inflammasome, as mice lacking caspase-1, ASC, or NLRP3 exhibit partially defective responses after immunization. Biochemical fractionation studies further revealed that peptidoglycan is the major component of heat-killed mycobacteria responsible for inflammasome activation. By assaying Il1b transcripts in the injection site skin of CFA-immunized mice, we found that signaling through the adaptor molecule caspase activation and recruitment domain 9 (CARD9) plays a major role in triggering pro-IL-1β expression. Moreover, we demonstrated that recognition of the mycobacterial glycolipid trehalose dimycolate (cord factor) by the C-type lectin receptor mincle partially explains this CARD9 requirement. Importantly, purified peptidoglycan and cord factor administered in mineral oil synergized to recapitulate the Th17-promoting activity of CFA, and, as expected, this response was diminished in caspase-1- and CARD9-deficient mice. Taken together, these findings suggest a general strategy for the rational design of Th17-skewing adjuvants by combining agonists of the CARD9 pathway with inflammasome activators. PMID:23630357
Ruffini, Remo; Wheeler, John A.
1971-01-01
discusses the cosmology theory of a black hole, a region where an object loses its identity, but mass, charge, and momentum are conserved. Include are three possible formation processes, theorized properties, and three way they might eventually be detected. (DS)
... dling boxes, firewood, lumber, and rocks, etc. The black widow is commonly found in the following places: • Outdoors - woodpiles, rubble piles, under stones, in hol- low stumps, and in rodent burrows, privies, sheds ...
Shipboard, high volume air particulate samples were collected from the Black Sea atmosphere and analyzed by instrumental neutron activation analysis, atomic absorption spectrophotometry and ion chromatography for about 40 elements and ions. Concentrations of elements in the eastern and western parts of the Black Sea are different at the 95% confidence level, with lower concentrations in the eastern Black Sea. Back-trajectories and concentrations of elements in trajectory groups show that Europe accounts for more than 70% of the anthropogenic elements in the atmosphere. The average sulfate concentration was 7 μg/m3, which is comparable with rural sulfate levels in western Europe. Fluxes of elements from the atmosphere to the Black Sea are in good agreement with the results of similar flux calculations for other regions
Black Friday = Broget Branding?
Hansen, Heidi
2015-01-01
Black Friday er et godt eksempel på, hvordan ikke kun produktbrands og corporate brands rejser på tværs af landegrænser, men også traditioner som Halloween, Valentines Day og i dette tilfælde den ultimative tilbuds-fredag, som i USA går under navnet Black Friday. Men hvad er Black Friday i Danmark......? Essensen ved Black Friday er lave priser, og det er der ved første øjekast ikke mange brandingmuligheder forbundet ved, hvis man forstår branding som en måde at skabe ekstra værdi omkring sit produkt eller sin virksomhed. Som brand bliver man dog alligevel nødt til at forholde sig til konceptet, da det er...
In this review we shall concentrate on the application of the concept of black hole to different areas in astrophysics. Models in which this idea is involved are connected with basically two areas in astrophysics: a) The death of massive stars due to gravitational collapse. This process would lead to the formation of black holes with stellar masses (10-20 M sun). The detection of these kind of - objects is in principle possible, by means of studying the so-called X-ray binary system. b) Active nuclei of galaxies, including quasars as an extreme case. In this case, the best model available to explain the generation of the enormous amounts of energy observed as well as several other properties, is accretion into a supermassive black hole (106-1010 M sun) in the center. The problem of the origin of such black holes is related to cosmology. (author)
Cosmic censorship inside black holes
Thorlacius, L
2006-01-01
A simple argument is given that a traversable Cauchy horizon inside a black hole is incompatible with unitary black hole evolution. The argument assumes the validity of black hole complementarity and applies to a generic black hole carrying angular momentum and/or charge. In the second part of the paper we review recent work on the semiclassical geometry of two-dimensional charged black holes.
Bekenstein, Jacob D.
1997-01-01
In some respects the black hole plays the same role in gravitation that the atom played in the nascent quantum mechanics. This analogy suggests that black hole mass $M$ might have a discrete spectrum. I review the physical arguments for the expectation that black hole horizon area eigenvalues are uniformly spaced, or equivalently, that the spacing between stationary black hole mass levels behaves like 1/M. This sort of spectrum has also emerged in a variety of formal approaches to black hole ...
Stornaiolo, Cosimo
2001-01-01
In this paper we propose a model for the formation of the cosmological voids. We show that cosmological voids can form directly after the collapse of extremely large wavelength perturbations into low-density black holes or cosmological black holes (CBH). Consequently the voids are formed by the comoving expansion of the matter that surrounds the collapsed perturbation. It follows that the universe evolves, in first approximation, according to the Einstein-Straus cosmological model. We discuss...
No particle theory can be complete without gravity. Einstein's theory of gravity is of the Euler-Lagrange form, but standard quantization procedure fails. In quantum gravity the higher order interactions have a dimensionality different form the fundamental ones, because Newton's constant G has dimensions and the renormalization procedure fails. Another problem with quantum gravity is even more mysterious. Suppose that we had regularized the gravitational forces at the small distance end in the way that the weak intermediate vector boson regularized the fundamental 4-fermion interaction vertex of the weak interactions. Then what we discover is that the gravitational forces are unstable. Given sufficiently large amount of matter, it can collapse under its own weight. Classical general relativity tells us what will happen: a black hole is formed. But how is this formulated in quantum theory. S. Hawking observed that when a field theory is quantized in the background metric of a black hole, the black hole actually emits particles in a completely random thermal way. Apparently black holes are just another form of matter unstable against Hawking decay. Unfortunately this picture cannot be complete. The problem is that the quantum version of black holes has infinite phase space, and other symptoms of a run-away solution. Black holes are the heaviest and most compact forms of matter that can be imagined. A complete particle theory can have nothing but a spectrum of black-hole like objects at it high-energy end. This is why it is believed that a resolution of the black hole problem will in time disclose the complete small-distance structure of our world. 6 references
Thermal corpuscular black holes
Casadio, Roberto; Giugno, Andrea; Orlandi, Alessio
2015-01-01
We study the corpuscular model of an evaporating black hole consisting of a specific quantum state for a large number $N$ of self-confined bosons. The single-particle spectrum contains a discrete ground state of energy $m$ (corresponding to toy gravitons forming the black hole), and a gapless continuous spectrum (to accommodate for the Hawking radiation with energy $\\omega>m$). Each constituent is in a superposition of the ground state and a Planckian distribution at the expected Hawking temp...
Gurvits, Grigoriy E; Tan, Amy
2014-01-01
Black hairy tongue (BHT) is a benign medical condition characterized by elongated filiform lingual papillae with typical carpet-like appearance of the dorsum of the tongue. Its prevalence varies geographically, typically ranging from 0.6% to 11.3%. Known predisposing factors include smoking, excessive coffee/black tea consumption, poor oral hygiene, trigeminal neuralgia, general debilitation, xerostomia, and medication use. Clinical presentation varies but is typically asymptomatic, although ...
Babichev, Eugeny; Charmousis, Christos; Hassaine, Mokhtar
2015-05-01
We consider an Abelian gauge field coupled to a particular truncation of Horndeski theory. The Galileon field has translation symmetry and couples non minimally both to the metric and the gauge field. When the gauge-scalar coupling is zero the gauge field reduces to a standard Maxwell field. By taking into account the symmetries of the action, we construct charged black hole solutions. Allowing the scalar field to softly break symmetries of spacetime we construct black holes where the scalar field is regular on the black hole event horizon. Some of these solutions can be interpreted as the equivalent of Reissner-Nordstrom black holes of scalar tensor theories with a non trivial scalar field. A self tuning black hole solution found previously is extended to the presence of dyonic charge without affecting whatsoever the self tuning of a large positive cosmological constant. Finally, for a general shift invariant scalar tensor theory we demonstrate that the scalar field Ansatz and method we employ are mathematically compatible with the field equations. This opens up the possibility for novel searches of hairy black holes in a far more general setting of Horndeski theory.
Black hole critical phenomena without black holes
Steven L Liebling
2000-10-01
Studying the threshold of black hole formation via numerical evolution has led to the discovery of fascinating nonlinear phenomena. Power-law mass scaling, aspects of universality, and self-similarity have now been found for a large variety of models. However, questions remain. Here I brieﬂy review critical phenomena, discuss some recent results, and describe a model which demonstrates similar phenomena without gravity.
NONE
2002-02-01
Belief in the existence of black holes is the ultimate act of faith for a physicist. First suggested by the English clergyman John Michell in the year 1784, the gravitational pull of a black hole is so strong that nothing - not even light - can escape. Gravity might be the weakest of the fundamental forces but black-hole physics is not for the faint-hearted. Black holes present obvious problems for would-be observers because they cannot, by definition, be seen with conventional telescopes - although before the end of the decade gravitational-wave detectors should be able to study collisions between black holes. Until then astronomers can only infer the existence of a black hole from its gravitational influence on other matter, or from the X-rays emitted by gas and dust as they are dragged into the black hole. However, once this material passes through the 'event horizon' that surrounds the black hole, we will never see it again - not even with X-ray specs. Despite these observational problems, most physicists and astronomers believe that black holes do exist. Small black holes a few kilometres across are thought to form when stars weighing more than about two solar masses collapse under the weight of their own gravity, while supermassive black holes weighing millions of solar masses appear to be present at the centre of most galaxies. Moreover, some brave physicists have proposed ways to make black holes - or at least event horizons - in the laboratory. The basic idea behind these 'artificial black holes' is not to compress a large amount of mass into a small volume, but to reduce the speed of light in a moving medium to less than the speed of the medium and so create an event horizon. The parallels with real black holes are not exact but the experiments could shed new light on a variety of phenomena. The first challenge, however, is to get money for the research. One year on from a high-profile meeting on artificial black holes in London, for
Anyonic statistics and large horizon diffeomorphisms for Loop Quantum Gravity Black Holes
Pithis, Andreas G A
2014-01-01
In this article we investigate the role played by large diffeomorphisms of quantum Isolated Horizons for the statistics of LQG Black Holes by means of their relation to the braid group. To this aim the symmetries of Chern-Simons theory are recapitulated with particular regard to the aforementioned type of diffeomorphisms. For the punctured spherical horizon, these are elements of the mapping class group of $S^2$, which is almost isomorphic to a corresponding braid group on this particular manifold. The mutual exchange of quantum entities in $2$-dimensions is communicated by the braid group, rendering the statistics anyonic. With this we argue that the quantum Isolated Horizon model of LQG based on $SU(2)_k$-Chern-Simons theory exhibits non-abelian anyonic statistics. In this way a connection to theory behind the fractional quantum Hall effect and that of topological quantum computation is established, where non-abelian anyons play a significant role.
Raheem Omer
2011-10-01
Full Text Available Abstract Prostate cancer metastasizes to bone in the majority of patients with advanced disease leading to painfully debilitating fractures, spinal compression and rapid decline. In addition, prostate cancer bone metastases often become resistant to standard therapies including androgen deprivation, radiation and chemotherapy. There are currently few models to elucidate mechanisms of interaction between the bone microenvironment and prostate cancer. It is, thus, essential to develop new patient-derived, orthotopic models. Here we report the development and characterization of PCSD1 (Prostate Cancer San Diego 1, a novel patient-derived intra-femoral xenograft model of prostate bone metastatic cancer that recapitulates mixed osteolytic and osteoblastic lesions. Methods A femoral bone metastasis of prostate cancer was removed during hemiarthroplasty and transplanted into Rag2-/-;γc-/- mice either intra-femorally or sub-cutaneously. Xenograft tumors that developed were analyzed for prostate cancer biomarker expression using RT-PCR and immunohistochemistry. Osteoblastic, osteolytic and mixed lesion formation was measured using micro-computed tomography (microCT. Results PCSD1 cells isolated directly from the patient formed tumors in all mice that were transplanted intra-femorally or sub-cutaneously into Rag2-/-;γc-/- mice. Xenograft tumors expressed human prostate specific antigen (PSA in RT-PCR and immunohistochemical analyses. PCSD1 tumors also expressed AR, NKX3.1, Keratins 8 and 18, and AMACR. Histologic and microCT analyses revealed that intra-femoral PCSD1 xenograft tumors formed mixed osteolytic and osteoblastic lesions. PCSD1 tumors have been serially passaged in mice as xenografts intra-femorally or sub-cutaneously as well as grown in culture. Conclusions PCSD1 xenografts tumors were characterized as advanced, luminal epithelial prostate cancer from a bone metastasis using RT-PCR and immunohistochemical biomarker analyses. PCSD1 intra
Taki, K; Ohmuraya, M; Tanji, E; Komatsu, H; Hashimoto, D; Semba, K; Araki, K; Kawaguchi, Y; Baba, H; Furukawa, T
2016-05-01
Intraductal papillary mucinous neoplasm (IPMN), the most common pancreatic cystic neoplasm, is known to progress to invasive ductal adenocarcinoma. IPMNs commonly harbor activating somatic mutations in GNAS and KRAS, primarily GNAS(R201H) and KRAS(G12D). GNAS encodes the stimulatory G-protein α subunit (Gsα) that mediates a stimulatory signal to adenylyl cyclase to produce cyclic adenosine monophosphate (cAMP), subsequently activating cAMP-dependent protein kinase A. The GNAS(R201H) mutation results in constitutive activation of Gsα. To study the potential role of GNAS in pancreatic tumorigenesis in vivo, we generated lines of transgenic mice in which the transgene consisted of Lox-STOP-Lox (LSL)-GNAS(R201H) under the control of the CAG promoter (Tg(CAG-LSL-GNAS)). These mice were crossed with pancreatic transcription factor 1a (Ptf1a)-Cre mice (Ptf1a(Cre/+)), generating Tg(CAG-LSL-GNAS);Ptf1a(Cre/+) mice. This mouse line showed elevated cAMP levels, small dilated tubular complex formation, loss of acinar cells and fibrosis in the pancreas; however, no macroscopic tumorigenesis was apparent by 2 months of age. We then crossed Tg(CAG-LSL-GNAS);Ptf1a(Cre/+) mice with LSL-Kras(G12D) mice, generating Tg(CAG-LSL-GNAS);LSL-Kras(G12D);Ptf1a(Cre/+) mice. We used these mice to investigate a possible cooperative effect of GNAS(R201H) and Kras(G12D) in pancreatic tumorigenesis. Within 5 weeks, Tg(CAG-LSL-GNAS);LSL-Kras(G12D);Ptf1a(Cre/+) mice developed a cystic tumor consisting of marked dilated ducts lined with papillary dysplastic epithelia in the pancreas, which closely mimicked the human IPMN. Our data strongly suggest that activating mutations in GNAS and Kras cooperatively promote murine pancreatic tumorigenesis, which recapitulates IPMN. Our mouse model may serve as a unique in vivo platform to find biomarkers and effective drugs for diseases associated with GNAS mutations. PMID:26257060
Ajioka Itsuki
2007-09-01
Full Text Available Abstract Background Development of multicellular organisms proceeds from a single fertilized egg as the combined effect of countless numbers of cellular interactions among highly dynamic cells. Since at least a reminiscent pattern of morphogenesis can be recapitulated in a reproducible manner in reaggregation cultures of dissociated embryonic cells, which is known as cell sorting, the cells themselves must possess some autonomous cell behaviors that assure specific and reproducible self-organization. Understanding of this self-organized dynamics of heterogeneous cell population seems to require some novel approaches so that the approaches bridge a gap between molecular events and morphogenesis in developmental and cell biology. A conceptual cell model in a computer may answer that purpose. We constructed a dynamical cell model based on autonomous cell behaviors, including cell shape, growth, division, adhesion, transformation, and motility as well as cell-cell signaling. The model gives some insights about what cellular behaviors make an appropriate global pattern of the cell population. Results We applied the model to "inside and outside" pattern of cell-sorting, in which two different embryonic cell types within a randomly mixed aggregate are sorted so that one cell type tends to gather in the central region of the aggregate and the other cell type surrounds the first cell type. Our model can modify the above cell behaviors by varying parameters related to them. We explored various parameter sets with which the "inside and outside" pattern could be achieved. The simulation results suggested that direction of cell movement responding to its neighborhood and the cell's mobility are important for this specific rearrangement. Conclusion We constructed an in silico cell model that mimics autonomous cell behaviors and applied it to cell sorting, which is a simple and appropriate phenomenon exhibiting self-organization of cell population. The model
Hawking, S. W.
1996-03-01
One would expect spacetime to have a foamlike structure on the Planck scale with a very high topology. If spacetime is simply connected (which is assumed in this paper), the nontrivial homology occurs in dimension two, and spacetime can be regarded as being essentially the topological sum of S2×S2 and K3 bubbles. Comparison with the instantons for pair creation of black holes shows that the S2×S2 bubbles can be interpreted as closed loops of virtual black holes. It is shown that scattering in such topological fluctuations leads to loss of quantum coherence, or in other words, to a superscattering matrix S/ that does not factorize into an S matrix and its adjoint. This loss of quantum coherence is very small at low energies for everything except scalar fields, leading to the prediction that we may never observe the Higgs particle. Another possible observational consequence may be that the θ angle of QCD is zero without having to invoke the problematical existence of a light axion. The picture of virtual black holes given here also suggests that macroscopic black holes will evaporate down to the Planck size and then disappear in the sea of virtual black holes.
Babichev, Eugeny; Hassaine, Mokhtar
2015-01-01
We consider an Abelian gauge field coupled to a particular truncation of Horndeski theory. The Galileon field has translation symmetry and couples non minimally both to the metric and the gauge field. When the gauge-scalar coupling is zero the gauge field reduces to a standard Maxwell field. By taking into account the symmetries of the action, we construct charged black hole solutions. Allowing the scalar field to softly break symmetries of spacetime we construct black holes where the scalar field is regular on the black hole event horizon. Some of these solutions can be interpreted as the equivalent of Reissner-Nordstrom black holes of scalar tensor theories with a non trivial scalar field. A self tuning black hole solution found previously is extended to the presence of dyonic charge without affecting whatsoever the self tuning of a large positive cosmological constant. Finally, for a general shift invariant scalar tensor theory we demonstrate that the scalar field Ansatz and method we employ are mathematic...
ZHAO Liu
2007-01-01
Hawking radiation of black ring solutions to 5-dimensional Einstein-Maxwell-dilaton theory is analyzed by use of the Parikh-Wilczek tunneling method. To get the correct tunneling amplitude and emission rate, we adopt and develop the Angheben-Nadalini-Vanzo-Zerbini covariant approach to cover the effects of rotation and electronic discharge all at once, and the effect of back reaction is also taken into account. This constitutes a unified approach to the tunneling problem. Provided the first law of thermodynamics for black rings holds, the emission rate is proportional to the exponential of the change of Bekenstein-Hawking entropy. Explicit calculation for black ring temperatures agrees exactly with the results obtained via the classical surface gravity method and the quasi-local formalism.
Noncommutative black hole thermodynamics
We give a general derivation, for any static spherically symmetric metric, of the relation Th=(K/2π) connecting the black hole temperature (Th) with the surface gravity (K), following the tunneling interpretation of Hawking radiation. This derivation is valid even beyond the semi-classical regime, i.e. when quantum effects are not negligible. The formalism is then applied to a spherically symmetric, stationary noncommutative Schwarzschild space-time. The effects of backreaction are also included. For such a black hole the Hawking temperature is computed in a closed form. A graphical analysis reveals interesting features regarding the variation of the Hawking temperature (including corrections due to noncommutativity and backreaction) with the small radius of the black hole. The entropy and tunneling rate valid for the leading order in the noncommutative parameter are calculated. We also show that the noncommutative Bekenstein-Hawking area law has the same functional form as the usual one
Yang, Huan; Zimmerman, Aaron; Lehner, Luis
2015-02-27
We demonstrate that rapidly spinning black holes can display a new type of nonlinear parametric instability-which is triggered above a certain perturbation amplitude threshold-akin to the onset of turbulence, with possibly observable consequences. This instability transfers from higher temporal and azimuthal spatial frequencies to lower frequencies-a phenomenon reminiscent of the inverse cascade displayed by (2+1)-dimensional fluids. Our finding provides evidence for the onset of transitory turbulence in astrophysical black holes and predicts observable signatures in black hole binaries with high spins. Furthermore, it gives a gravitational description of this behavior which, through the fluid-gravity duality, can potentially shed new light on the remarkable phenomena of turbulence in fluids. PMID:25768746
General consensus on the nature of the degrees of freedom responsible for the black hole entropy remains elusive despite decades of effort dedicated to the problem. Different approaches to quantum gravity disagree in their description of the microstates and, more significantly, in the statistics used to count them. In some approaches (string theory, AdS/CFT) the elementary degrees of freedom are indistinguishable, whereas they must be treated as distinguishable in other approaches to quantum gravity (eg., LQG) in order to recover the Bekenstein-Hawking area-entropy law. However, different statistics will imply different behaviors of the black hole outside the thermodynamic limit. We illustrate this point by quantizing the Bañados-Teitelboim-Zanelli (BTZ) black hole, for which we argue that Bose condensation will occur leading to a cold, stable remnant
Vaz, Cenalo; Wijewardhana, L. C. R.
2013-12-01
General consensus on the nature of the degrees of freedom responsible for the black hole entropy remains elusive despite decades of effort dedicated to the problem. Different approaches to quantum gravity disagree in their description of the microstates and, more significantly, in the statistics used to count them. In some approaches (string theory, AdS/CFT) the elementary degrees of freedom are indistinguishable, whereas they must be treated as distinguishable in other approaches to quantum gravity (eg., LQG) in order to recover the Bekenstein-Hawking area-entropy law. However, different statistics will imply different behaviors of the black hole outside the thermodynamic limit. We illustrate this point by quantizing the Bañados-Teitelboim-Zanelli (BTZ) black hole, for which we argue that Bose condensation will occur leading to a "cold", stable remnant.
Centrella, Joan
2012-01-01
The final merger of two black holes is expected to be the strongest source of gravitational waves for both ground-based detectors such as LIGO and VIRGO, as well as future. space-based detectors. Since the merger takes place in the regime of strong dynamical gravity, computing the resulting gravitational waveforms requires solving the full Einstein equations of general relativity on a computer. For many years, numerical codes designed to simulate black hole mergers were plagued by a host of instabilities. However, recent breakthroughs have conquered these instabilities and opened up this field dramatically. This talk will focus on.the resulting 'gold rush' of new results that is revealing the dynamics and waveforms of binary black hole mergers, and their applications in gravitational wave detection, testing general relativity, and astrophysics
Fischetti, Sebastian
2013-01-01
We construct the gravitational dual, in the Unruh state, of the "jammed" phase of a CFT at strong coupling and infinite N on a fixed five-dimensional rotating Myers-Perry black hole with equal angular momenta. When the angular momenta are all zero, the solution corresponds to the five-dimensional generalization of the solution first studied by Figueras, Lucietti, and Wiseman. In the extremal limit, when the angular momenta of the Myers-Perry black hole are maximum, the Unruh, Boulware and Hartle-Hawking states degenerate. We give a detailed analysis of the corresponding holographic stress energy tensor for all values of the angular momenta, finding it to be regular at the horizon in all cases. We compare our results with existent literature on thermal states of free field theories on black hole backgrounds.
Yang, Huan; Lehner, Luis
2014-01-01
We show that rapidly-spinning black holes can display turbulent gravitational behavior which is mediated by a new type of parametric instability. This instability transfers energy from higher temporal and azimuthal spatial frequencies to lower frequencies--- a phenomenon reminiscent of the inverse energy cascade displayed by 2+1-dimensional turbulent fluids. Our finding reveals a path towards gravitational turbulence for perturbations of rapidly-spinning black holes, and provides the first evidence for gravitational turbulence in an asymptotically flat spacetime. Interestingly, this finding predicts observable gravitational wave signatures from such phenomena in black hole binaries with high spins and gives a gravitational description of turbulence relevant to the fluid-gravity duality.
Yang, Huan; Zimmerman, Aaron; Lehner, Luis
2015-02-01
We demonstrate that rapidly spinning black holes can display a new type of nonlinear parametric instability—which is triggered above a certain perturbation amplitude threshold—akin to the onset of turbulence, with possibly observable consequences. This instability transfers from higher temporal and azimuthal spatial frequencies to lower frequencies—a phenomenon reminiscent of the inverse cascade displayed by (2 +1 )-dimensional fluids. Our finding provides evidence for the onset of transitory turbulence in astrophysical black holes and predicts observable signatures in black hole binaries with high spins. Furthermore, it gives a gravitational description of this behavior which, through the fluid-gravity duality, can potentially shed new light on the remarkable phenomena of turbulence in fluids.
The 'no-hair' theorem, a key result in general relativity, states that an isolated black hole is defined by only three parameters: mass, angular momentum, and electric charge; this asymptotic state is reached on a light-crossing time scale. We find that the no-hair theorem is not formally applicable for black holes formed from the collapse of a rotating neutron star. Rotating neutron stars can self-produce particles via vacuum breakdown forming a highly conducting plasma magnetosphere such that magnetic field lines are effectively ''frozen in'' the star both before and during collapse. In the limit of no resistivity, this introduces a topological constraint which prohibits the magnetic field from sliding off the newly-formed event horizon. As a result, during collapse of a neutron star into a black hole, the latter conserves the number of magnetic flux tubes NB=eΦ∞/(πc(ℎ/2π)), where Φ∞≅2π2BNSRNS3/(PNSc) is the initial magnetic flux through the hemispheres of the progenitor and out to infinity. We test this theoretical result via 3-dimensional general relativistic plasma simulations of rotating black holes that start with a neutron star dipole magnetic field with no currents initially present outside the event horizon. The black hole's magnetosphere subsequently relaxes to the split-monopole magnetic field geometry with self-generated currents outside the event horizon. The dissipation of the resulting equatorial current sheet leads to a slow loss of the anchored flux tubes, a process that balds the black hole on long resistive time scales rather than the short light-crossing time scales expected from the vacuum no-hair theorem.
Lyutikov, Maxim; McKinney, Jonathan C.
2011-10-01
The “no-hair” theorem, a key result in general relativity, states that an isolated black hole is defined by only three parameters: mass, angular momentum, and electric charge; this asymptotic state is reached on a light-crossing time scale. We find that the no-hair theorem is not formally applicable for black holes formed from the collapse of a rotating neutron star. Rotating neutron stars can self-produce particles via vacuum breakdown forming a highly conducting plasma magnetosphere such that magnetic field lines are effectively “frozen in” the star both before and during collapse. In the limit of no resistivity, this introduces a topological constraint which prohibits the magnetic field from sliding off the newly-formed event horizon. As a result, during collapse of a neutron star into a black hole, the latter conserves the number of magnetic flux tubes NB=eΦ∞/(πcℏ), where Φ∞≈2π2BNSRNS3/(PNSc) is the initial magnetic flux through the hemispheres of the progenitor and out to infinity. We test this theoretical result via 3-dimensional general relativistic plasma simulations of rotating black holes that start with a neutron star dipole magnetic field with no currents initially present outside the event horizon. The black hole’s magnetosphere subsequently relaxes to the split-monopole magnetic field geometry with self-generated currents outside the event horizon. The dissipation of the resulting equatorial current sheet leads to a slow loss of the anchored flux tubes, a process that balds the black hole on long resistive time scales rather than the short light-crossing time scales expected from the vacuum no-hair theorem.
The black hole information paradox forces us into a strange situation: we must find a way to break the semiclassical approximation in a domain where no quantum gravity effects would normally be expected. Traditional quantizations of gravity do not exhibit any such breakdown, and this forces us into a difficult corner: either we must give up quantum mechanics or we must accept the existence of troublesome ‘remnants’. In string theory, however, the fundamental quanta are extended objects, and it turns out that the bound states of such objects acquire a size that grows with the number of quanta in the bound state. The interior of the black hole gets completely altered to a ‘fuzzball’ structure, and information is able to escape in radiation from the hole. The semiclassical approximation can break at macroscopic scales due to the large entropy of the hole: the measure in the path integral competes with the classical action, instead of giving a subleading correction. Putting this picture of black hole microstates together with ideas about entangled states leads to a natural set of conjectures on many long-standing questions in gravity: the significance of Rindler and de Sitter entropies, the notion of black hole complementarity, and the fate of an observer falling into a black hole. - Highlights: ► The information paradox is a serious problem. ► To solve it we need to find ‘hair’ on black holes. ► In string theory we find ‘hair’ by the fuzzball construction. ► Fuzzballs help to resolve many other issues in gravity.
Exact solutions of higher dimensional black holes
Tomizawa, Shinya
2011-01-01
We review exact solutions of black holes in higher dimensions, focusing on asymptotically flat black hole solutions and Kaluza-Klein type black hole solutions. We also summarize some properties which such black hole solutions reveal.
Lisin, M.A. [Koon-Hall-Adrian Metallurgical, Portland, OR (United States)
1996-11-01
Black light photography of fluorescent penetrant and wet fluorescent magnetic particle indications can yield spectacular and useful results. The technique provides a lasting record of a flaw`s severity and location, as well as its physical relation to other components and important features. The procedures are easily learned and do not require sophisticated apparatus. In fact, equipment costs can often be justified on the basis of a single application. Using the techniques described in this article, black light photography can be a cost-effective, informative NDT tool.
Noncommutative solitonic black hole
We investigate solitonic black hole solutions in three-dimensional noncommutative spacetime. We do this in gravity with a negative cosmological constant coupled to a scalar field. Noncommutativity is realized with the Moyal product which is expanded up to first order in the noncommutativity parameter in two spatial directions. With numerical simulation we study the effect of noncommutativity by increasing the value of the noncommutativity parameter starting from commutative solutions. We find that even a regular soliton solution in the commutative case becomes a black hole solution when the noncommutativity parameter reaches a certain value. (paper)
Noncommutative solitonic black hole
Chang-Young, Ee; Kimm, Kyoungtae; Lee, Daeho; Lee, Youngone
2012-05-01
We investigate solitonic black hole solutions in three-dimensional noncommutative spacetime. We do this in gravity with a negative cosmological constant coupled to a scalar field. Noncommutativity is realized with the Moyal product which is expanded up to first order in the noncommutativity parameter in two spatial directions. With numerical simulation we study the effect of noncommutativity by increasing the value of the noncommutativity parameter starting from commutative solutions. We find that even a regular soliton solution in the commutative case becomes a black hole solution when the noncommutativity parameter reaches a certain value.
Hennigar, Robie A; Tjoa, Erickson
2016-01-01
We present what we believe is the first example of a "$\\lambda$-line" phase transition in black hole thermodynamics. This is a line of (continuous) second order phase transitions which in the case of liquid $^4$He marks the onset of superfluidity. The phase transition occurs for a class of asymptotically AdS hairy black holes in Lovelock gravity where a real scalar field is conformally coupled to gravity. We discuss the origin of this phase transition and outline the circumstances under which it (or generalizations of it) could occur.
Hawking, Stephen W.
1995-01-01
One would expect spacetime to have a foam-like structure on the Planck scale with a very high topology. If spacetime is simply connected (which is assumed in this paper), the non-trivial homology occurs in dimension two, and spacetime can be regarded as being essentially the topological sum of $S^2\\times S^2$ and $K3$ bubbles. Comparison with the instantons for pair creation of black holes shows that the $S^2\\times S^2$ bubbles can be interpreted as closed loops of virtual black holes. It is ...
Aarseth, Sverre J
2007-01-01
We describe efforts over the last six years to implement regularization methods suitable for studying one or more interacting black holes by direct N-body simulations. Three different methods have been adapted to large-N systems: (i) Time-Transformed Leapfrog, (ii) Wheel-Spoke, and (iii) Algorithmic Regularization. These methods have been tried out with some success on GRAPE-type computers. Special emphasis has also been devoted to including post-Newtonian terms, with application to moderately massive black holes in stellar clusters. Some examples of simulations leading to coalescence by gravitational radiation will be presented to illustrate the practical usefulness of such methods.
Characterizing Black Hole Mergers
Baker, John; Boggs, William Darian; Kelly, Bernard
2010-01-01
Binary black hole mergers are a promising source of gravitational waves for interferometric gravitational wave detectors. Recent advances in numerical relativity have revealed the predictions of General Relativity for the strong burst of radiation generated in the final moments of binary coalescence. We explore features in the merger radiation which characterize the final moments of merger and ringdown. Interpreting the waveforms in terms of an rotating implicit radiation source allows a unified phenomenological description of the system from inspiral through ringdown. Common features in the waveforms allow quantitative description of the merger signal which may provide insights for observations large-mass black hole binaries.
Futterman, J.A.H.; Handler, F.A.; Matzner, R.A.
1987-01-01
This book provides a comprehensive treatment of the propagation of waves in the presence of black holes. While emphasizing intuitive physical thinking in their treatment of the techniques of analysis of scattering, the authors also include chapters on the rigorous mathematical development of the subject. Introducing the concepts of scattering by considering the simplest, scalar wave case of scattering by a spherical (Schwarzschild) black hole, the book then develops the formalism of spin weighted spheroidal harmonics and of plane wave representations for neutrino, electromagnetic, and gravitational scattering. Details and results of numerical computations are given. The techniques involved have important applications (references are given) in acoustical and radar imaging.
This book provides a comprehensive treatment of the propagation of waves in the presence of black holes. While emphasizing intuitive physical thinking in their treatment of the techniques of analysis of scattering, the authors also include chapters on the rigorous mathematical development of the subject. Introducing the concepts of scattering by considering the simplest, scalar wave case of scattering by a spherical (Schwarzschild) black hole, the book then develops the formalism of spin weighted spheroidal harmonics and of plane wave representations for neutrino, electromagnetic, and gravitational scattering. Details and results of numerical computations are given. The techniques involved have important applications (references are given) in acoustical and radar imaging
Visser, M
1999-01-01
Acoustic propagation in a moving fluid provides a conceptually clean and powerful analogy for understanding black hole physics. As a teaching tool, the analogy is useful for introducing students to both General Relativity and fluid mechanics. As a research tool, the analogy helps clarify what aspects of the physics are kinematics and what aspects are dynamics. In particular, Hawking radiation is a purely kinematical effect, whereas black hole entropy is intrinsically dynamical. Finally, I discuss the fact that with present technology acoustic Hawking radiation is almost experimentally testable.
Good, Michael R R
2014-01-01
A $(3+1)$-dimensional asymptotically flat Kerr black hole angular speed $\\Omega_+$ can be used to define an effective spring constant, $k=m\\Omega_+^2$. Its maximum value is the Schwarzschild surface gravity, $k = \\kappa $, which rapidly weakens as the black hole spins down and the temperature increases. The Hawking temperature is expressed in terms of the spring constant: $2\\pi T = \\kappa - k$. Hooke's law, in the extremal limit, provides the force $F = 1/4$, which is consistent with the conjecture of maximum force in general relativity.
Rafael Martínez-Girón
2013-01-01
Full Text Available Black-pigmented sputum, also called "melanoptysis," is a symptom that may be observed in certain pathologies such us coal workers′ pneumoconiosis (anthracosis. The cavitation and liquefaction of a fibrosed mass by an infectious process (tuberculosis, infections by anaerobes, etc. or by ischemic necrosis may cause expectoration of a blackish secretion. We report the case of a patient with labor precedents as a coal worker, from whom abundant black sputum was obtained in the course of an incidental expectoration. Cyto-histological findings are shown and a differential diagnosis is established.
Horndeski black hole geodesics
Tretyakova, D A
2016-01-01
We examine geodesics for the scalar-tensor black holes in the Horndeski-Galileon framework. Our analysis shows that first kind relativistic orbits may not be present within some model parameters range. This is a highly pathological behavior contradicting to the black hole accretion and Solar System observations. We also present a new (although very similar to those previously known) solution, which contains the orbits we expect from a compact object, admits regular scalar field at the horizon and and can fit into the known stability criteria.
Good, Michael R R
2016-01-01
A black mirror is an accelerated boundary that produces particles in an exact correspondence to an evaporating black hole. We investigate the spectral dynamics of the particle creation during the formation process.
Horowitz, Gary T.; Maldacena, Juan
2003-01-01
We propose that in quantum gravity one needs to impose a final state boundary condition at black hole singularities. This resolves the apparent contradiction between string theory and semiclassical arguments over whether black hole evaporation is unitary.
Quantum aspects of black holes
2015-01-01
Beginning with an overview of the theory of black holes by the editor, this book presents a collection of ten chapters by leading physicists dealing with the variety of quantum mechanical and quantum gravitational effects pertinent to black holes. The contributions address topics such as Hawking radiation, the thermodynamics of black holes, the information paradox and firewalls, Monsters, primordial black holes, self-gravitating Bose-Einstein condensates, the formation of small black holes in high energetic collisions of particles, minimal length effects in black holes and small black holes at the Large Hadron Collider. Viewed as a whole the collection provides stimulating reading for researchers and graduate students seeking a summary of the quantum features of black holes.
Conquering the Black Girl Blues.
Jones, Lani Valencia; Guy-Sheftall, Beverly
2015-10-01
An examination of the literature on epidemiology, etiology, and use of services for this population reveals an insufficient application of culturally congruent approaches to intervening with black women. An exploration of the social work practice literature and other relevant fields indicate that black feminist perspectives offer the opportunity to gain a clearer understanding of the intersection and influence of oppression among black women struggling with psychiatric issues and provide a useful framework for mental health practice with this population. This article discusses the evolving black feminist thought and summarizes the scholarship on black women's mental health services needs and utilization issues. The article includes a discussion of black feminisms as an emerging mental health perspective, arguing that black feminist perspectives in therapy provide an ideal framework for services that are responsive to the values and health needs of black women. The article concludes with a case vignette that illustrates some of its points. PMID:26489355
Black Hole Evaporation. A Survey
Benachenhou, Farid
1994-01-01
This thesis is a review of black hole evaporation with emphasis on recent results obtained for two dimensional black holes. First, the geometry of the most general stationary black hole in four dimensions is described and some classical quantities are defined. Then, a derivation of the spectrum of the radiation emitted during the evaporation is presented. In section four, a two dimensional model which has black hole solutions is introduced, the so-called CGHS model. These two dimensional blac...
Towards noncommutative quantum black holes
In this paper we study noncommutative black holes. We use a diffeomorphism between the Schwarzschild black hole and the Kantowski-Sachs cosmological model, which is generalized to noncommutative minisuperspace. Through the use of the Feynman-Hibbs procedure we are able to study the thermodynamics of the black hole, in particular, we calculate the Hawking's temperature and entropy for the noncommutative Schwarzschild black hole
Towards Noncommutative Quantum Black Holes
Lopez-Dominguez, J. C.; Obregon, O.; Ramirez, C.; Sabido, M.
2006-01-01
In this paper we study noncommutative black holes. We use a diffeomorphism between the Schwarzschild black hole and the Kantowski-Sachs cosmological model, which is generalized to noncommutative minisuperspace. Through the use of the Feynman-Hibbs procedure we are able to study the thermodynamics of the black hole, in particular, we calculate the Hawking's temperature and entropy for the noncommutative Schwarzschild black hole.
Chamblin, A; Reall, H S
2000-01-01
Gravitational collapse of matter trapped on a brane will produce a black hole on the brane. We discuss such black holes in the models of Randall and Sundrum where our universe is viewed as a domain wall in five dimensional anti-de Sitter space. We present evidence that a non-rotating uncharged black hole on the domain wall is described by a ``black cigar'' solution in five dimensions.
Chamblin, A.; Hawking, S. W.; Reall, H. S.
2000-03-01
Gravitational collapse of matter trapped on a brane will produce a black hole on the brane. We discuss such black holes in the models of Randall and Sundrum where our universe is viewed as a domain wall in five-dimensional anti-de Sitter space. We present evidence that a non-rotating uncharged black hole on the domain wall is described by a ``black cigar'' solution in five dimensions.
Black Holes in Higher Dimensions
Reall Harvey S.
2008-09-01
Full Text Available We review black-hole solutions of higher-dimensional vacuum gravity and higher-dimensional supergravity theories. The discussion of vacuum gravity is pedagogical, with detailed reviews of Myers–Perry solutions, black rings, and solution-generating techniques. We discuss black-hole solutions of maximal supergravity theories, including black holes in anti-de Sitter space. General results and open problems are discussed throughout.
Black Hole: The Interior Spacetime
Ong, Yen Chin
2016-01-01
The information loss paradox is often discussed from the perspective of the observers who stay outside of a black hole. However, the interior spacetime of a black hole can be rather nontrivial. We discuss the open problems regarding the volume of a black hole, and whether it plays any role in information storage. We also emphasize the importance of resolving the black hole singularity, if one were to resolve the information loss paradox.
Blacks and the Women's Movement.
Loiacono, Stephanie
1989-01-01
Although Black female leaders were influential in creating the modern women's movement, feminism has evolved differently for both Black and White women. Suggests that, although Black women have struggled largely against racial and economic inequalities, women of all colors and backgrounds should embrace their diversity and unite to oppose racism…
The Strengths of Black Families.
Hill, Robert B.
This report identifies and analyzes five strengths of black families: adaptability roles, strong kinship bonds, strong work orientation, strong religious orientation, and achievement orientation. These five characteristics have been functional for the survival, advancement, and stability of black families. Most discussions of black families tend…
Black carbon in marine sediments
Middelburg, J.J.; Nieuwenhuize, J.; Van Breugel, P.
1999-01-01
Concentrations of black carbon were determined for a number of marine sediments. A comparison of black carbon based on thermal oxidation and hot concentrated nitric acid pretreatments revealed that the latter significantly overestimates combustion derived carbon phases. Black carbon accounts for abo
Warped products and black holes
We apply the warped product space-time scheme to the Banados-Teitelboim-Zanelli black holes and the Reissner-Nordstroem-anti-de Sitter black hole to investigate their interior solutions in terms of warped products. It is shown that there exist no discontinuities of the Ricci and Einstein curvatures across event horizons of these black holes
Black Progress: Convergence or Cleavage?
Hill, Robert B.
1982-01-01
The popular view of a permanent Black underclass falling farther behind an expanding Black middle class is disputed by empirical evidence that the underclass is experiencing upward mobility. The discrepancy stems from social scientists' overreliance on cross-sectional data rather than longitudinal data in analyzing economic change among Blacks.…
Warped products and black holes
Hong, S T
2005-01-01
We apply the warped product spacetime scheme to the Banados-Teitelboim-Zanelli black holes and the Reissner-Nordstr\\"om-anti-de Sitter black hole to investigate their interior solutions in terms of warped products. It is shown that there exist no discontinuities of the Ricci and Einstein curvatures across event horizons of these black holes.
Black silicon with black bus-bar strings
Davidsen, Rasmus Schmidt; Tang, Peter Torben; Mizushima, Io;
2016-01-01
We present the combination of black silicon texturing and blackened bus-bar strings as a potential method for obtaining all-black solar panels, while using conventional, front-contacted solar cells. Black silicon was realized by mask-less reactive ion etching resulting in total, average reflectance...... below 0.5% across a 156x156 mm2 silicon wafer. Black bus-bars were realized by oxidized copper resulting in reflectance below 3% in the entire visible wavelength range. The combination of these two technologies may result in aesthetic, all-black panels based on conventional, front-contacted solar cells...
Baskin, Wade; Runes, Richard N.
This dictionary is an encyclopedic survey of the cultural background and development of the black American, covering the basic issues, events, contributions and biographies germane to the subject. The author-compiler is Chairman of Classical Languages Department at Southeastern State College, Durant, Oklahoma. Richard Runes is practicing law as a…
Noldon, Carl
2007-01-01
The author argues in this speech that one cannot expect students in the school system to know and understand the genius of Black history if the curriculum is Eurocentric, which is a residue of racism. He states that his comments are designed for the enlightenment of those who suffer from a school system that "hypocritically manipulates Black…
Science Teacher, 2005
2005-01-01
Scientists using NASA's Swift satellite say they have found newborn black holes, just seconds old, in a confused state of existence. The holes are consuming material falling into them while somehow propelling other material away at great speeds. "First comes a blast of gamma rays followed by intense pulses of x-rays. The energies involved are much…
Kohl, Arthur L.
1987-07-28
A concentrated aqueous black liquor containing carbonaceous material and alkali metal sulfur compounds is treated in a gasifier vessel containing a relatively shallow molten salt pool at its bottom to form a combustible gas and a sulfide-rich melt. The gasifier vessel, which is preferably pressurized, has a black liquor drying zone at its upper part, a black liquor solids gasification zone located below the drying zone, and a molten salt sulfur reduction zone which comprises the molten salt pool. A first portion of an oxygen-containing gas is introduced into the gas space in the gasification zone immediatley above the molten salt pool. The remainder of the oxygen-containing gas is introduced into the molten salt pool in an amount sufficient to cause gasification of carbonaceous material entering the pool from the gasification zone but not sufficient to create oxidizing conditions in the pool. The total amount of the oxygen-containing gas introduced both above the pool and into the pool constitutes between 25 and 55% of the amount required for complete combustion of the black liquor feed. A combustible gas is withdrawn from an upper portion of the drying zone, and a melt in which the sulfur content is predominantly in the form of alkali metal sulfide is withdrawn from the molten salt sulfur reduction zone.
Trichomicosis pubis: black variety.
Neri, I.; Frassetto, A; Pasquinelli, G.; Patrizi, A.
1994-01-01
A case of a 25 year old man with the black variety of trichomicosis pubis is presented on account of its extreme rareity. Scanning electron microscopy confirms that trichomicosis pubis is caused by bacterial colonisation of the pubic hair and shows that bacteria are able to penetrate cuticular horny cells directly through their free plasma membrane.
We investigate the structure of the steady-state force-free magnetosphere around a Kerr black hole in various astrophysical settings. The solution Ψ(r, θ) depends on the distributions of the magnetic field line angular velocity ω(Ψ) and the poloidal electric current I(Ψ). These are obtained self-consistently as eigenfunctions that allow the solution to smoothly cross the two singular surfaces of the problem, the inner light surface inside the ergosphere, and the outer light surface, which is the generalization of the pulsar light cylinder. Magnetic field configurations that cross both singular surfaces (e.g., monopole, paraboloidal) are uniquely determined. Configurations that cross only one light surface (e.g., the artificial case of a rotating black hole embedded in a vertical magnetic field) are degenerate. We show that, similar to pulsars, black hole magnetospheres naturally develop an electric current sheet that potentially plays a very important role in the dissipation of black hole rotational energy and in the emission of high-energy radiation.
Baker, John
2010-01-01
Among the fascinating phenomena predicted by General Relativity, Einstein's theory of gravity, black holes and gravitational waves, are particularly important in astronomy. Though once viewed as a mathematical oddity, black holes are now recognized as the central engines of many of astronomy's most energetic cataclysms. Gravitational waves, though weakly interacting with ordinary matter, may be observed with new gravitational wave telescopes, opening a new window to the universe. These observations promise a direct view of the strong gravitational dynamics involving dense, often dark objects, such as black holes. The most powerful of these events may be merger of two colliding black holes. Though dark, these mergers may briefly release more energy that all the stars in the visible universe, in gravitational waves. General relativity makes precise predictions for the gravitational-wave signatures of these events, predictions which we can now calculate with the aid of supercomputer simulations. These results provide a foundation for interpreting expect observations in the emerging field of gravitational wave astronomy.
Rouse, Donald E.
This study describes and assesses the basic problems of black males who enter educational administration as a career, showing the relationship between their cultural background and their aspirations in the field of administration of a large city school system. The role taken by the researcher is that of participant-observer. The collection of…
Observational Evidence for Black Holes
Narayan, Ramesh; McClintock, Jeffrey E.
2013-01-01
Astronomers have discovered two populations of black holes: (i) stellar-mass black holes with masses in the range 5 to 30 solar masses, millions of which are present in each galaxy in the universe, and (ii) supermassive black holes with masses in the range 10^6 to 10^{10} solar masses, one each in the nucleus of every galaxy. There is strong circumstantial evidence that all these objects are true black holes with event horizons. The measured masses of supermassive black hole are strongly corr...
Bouhmadi-Lopez, Mariam; Cardoso, Vitor; Nerozzi, Andrea; Rocha, Jorge V, E-mail: mariam.bouhmadi@ist.utl.pt, E-mail: vitor.cardoso@ist.utl.pt, E-mail: andrea.nerozzi@ist.utl.pt, E-mail: jorge.v.rocha@ist.utl.pt [CENTRA, Department de Fisica, Instituto Superior Tecnico, Av. Rovisco Pais 1, 1049 Lisboa (Portugal)
2011-09-22
A possible process to destroy a black hole consists on throwing point particles with sufficiently large angular momentum into the black hole. In the case of Kerr black holes, it was shown by Wald that particles with dangerously large angular momentum are simply not captured by the hole, and thus the event horizon is not destroyed. Here we reconsider this gedanken experiment for black holes in higher dimensions. We show that this particular way of destroying a black hole does not succeed and that Cosmic Censorship is preserved.
Statistical mechanics of black holes
We analyze the statistical mechanics of a gas of neutral and charged black holes. The microcanonical ensemble is the only possible approach to this system, and the equilibrium configuration is the one for which most of the energy is carried by a single black hole. Schwarzschild black holes are found to obey the statistical bootstrap condition. In all cases, the microcanonical temperature is identical to the Hawking temperature of the most massive black hole in the gas. U(1) charges in general break the bootstrap property. The problems of black-hole decay and of quantum coherence are also addressed
Kao, Robert
2010-01-01
Get the most juice out of your BlackBerry handheld!. Feature-rich and complex, the BlackBerry is the number one smartphone in the corporate world is among the most popular handhelds for business users. This new and updated edition includes all the latest and greatest information on new and current BlackBerry mobile devices. Covering a range of valuable how-to topics, this helpful guide explores the BlackBerry's most useful features, techniques for getting the most out of your BlackBerry, and practical information about power usage.: Covers all aspects of the number one smartphone in the corpor
Prisons of light : black holes
Ferguson, Kitty
What is a black hole? Could we survive a visit to one -- perhaps even venture inside? Have we yet discovered any real black holes? And what do black holes teach us about the mysteries of our Universe? These are just a few of the tantalizing questions examined in this tour-de-force, jargon-free review of one of the most fascinating topics in modern science. In search of the answers, we trace a star from its birth to its death throes, take a hypothetical journey to the border of a black hole and beyond, spend time with some of the world's leading theoretical physicists and astronomers, and take a whimsical look at some of the wild ideas black holes have inspired. Prisons of Light - Black Holes is comprehensive and detailed. Yet Kitty Ferguson's lightness of touch and down-to-earth analogies set this book apart from all others on black holes and make it a wonderfully stimulating and entertaining read.
Point mass Cosmological Black Holes
Firouzjaee, Javad T
2016-01-01
Real black holes in the universe are located in the expanding accelerating background which are called the cosmological black holes. Hence, it is necessary to model these black holes in the cosmological background where the dark energy is the dominant energy. In this paper, we argue that most of the dynamical cosmological black holes can be modeled by point mass cosmological black holes. Considering the de Sitter background for the accelerating universe, we present the point mass cosmological background in the cosmological de Sitter space time. Our work also includes the point mass black holes which have charge and angular momentum. We study the mass, horizons, redshift structure and geodesics properties for these black holes.
Caged black holes: Black holes in compactified spacetimes. I. Theory
In backgrounds with compact dimensions there may exist several phases of black objects including a black hole and a black string. The phase transition between them raises questions and touches on fundamental issues such as topology change, uniqueness, and cosmic censorship. No analytic solution is known for the black hole, and moreover one can expect approximate solutions only for very small black holes, while phase transition physics happens when the black hole is large. Hence we turn to numerical solutions. Here some theoretical background to the numerical analysis is given, while the results will appear in a subsequent paper. The goals for a numerical analysis are set. The scalar charge and tension along the compact dimension are defined and used as improved order parameters which put both the black hole and the black string at finite values on the phase diagram. The predictions for small black holes are presented. The differential and the integrated forms of the first law are derived, and the latter (Smarr's formula) can be used to estimate the 'overall numerical error'. Field asymptotics and expressions for physical quantities in terms of the numerical values are supplied. The techniques include the 'method of equivalent charges', free energy, dimensional reduction, and analytic perturbation for small black holes
Pau, Evelyn; Loh, Christina; Minty, Gillian E.S.; Chang, Nan-Hua; Wither, Joan E.
2016-01-01
Systemic lupus erythematosus is a chronic multi-organ autoimmune disease marked mainly by the production of anti-nuclear antibodies. Nuclear antigens become accessible to the immune system following apoptosis and defective clearance of apoptotic debris has been shown in several knockout mouse models to promote lupus. However, genetic loci associated with defective clearance are not well defined in spontaneously arising lupus models. We previously showed that introgression of the chromosome 13 interval from lupus-prone New Zealand Black (NZB) mice onto a non-autoimmune B6 genetic background (B6.NZBc13) recapitulated many of the NZB autoimmune phenotypes. Here, we show that B6.NZBc13 mice have impaired clearance of apoptotic debris by peritoneal and tingible-body macrophages and have narrowed down the chromosomal interval of this defect using subcongenic mice with truncated NZB chromosome 13 intervals. This chromosomal region (81–94 Mb) is sufficient to produce polyclonal B and T cell activation, and expansion of dendritic cells. To fully recapitulate the autoimmune phenotypes seen in B6.NZBc13 mice, at least one additional locus located in the centromeric portion of the interval is required. Thus, we have identified a novel lupus susceptibility locus on NZB chromosome 13 that is associated with impaired clearance of apoptotic debris. PMID:23328841
I. Cabrera-Munguia
2015-04-01
Full Text Available A 6-parametric asymptotically flat exact solution, describing a two-body system of asymmetric black dyons, is studied. The system consists of two unequal counterrotating Kerr–Newman black holes, endowed with electric and magnetic charges which are equal but opposite in sign, separated by a massless strut. The Smarr formula is generalized in order to take into account their contribution to the mass. The expressions for the horizon half-length parameters σ1 and σ2, as functions of the Komar parameters and of the coordinate distance, are displayed, and the thermodynamic properties of the two-body system are studied. Furthermore, the seven physical parameters satisfy a simple algebraic relation which can be understood as a dynamical scenario, in which the physical properties of one body are affected by the ones of the other body.
Bena, Iosif; Vercnocke, Bert
2012-01-01
We establish the relation between the structure governing supersymmetric and non-supersymmetric four- and five-dimensional black holes and multicenter solutions and Calabi-Yau flux compactifications of M-theory and type IIB string theory. We find that the known BPS and almost-BPS multicenter black hole solutions can be interpreted as GKP compactifications with (2,1) and (0,3) imaginary self-dual flux. We also show that the most general GKP compactification leads to new classes of BPS and non-BPS multicenter solutions. We explore how these solutions fit into N=2 truncations, and elucidate how supersymmetry becomes camouflaged. As a necessary tool in our exploration we show how the fields in the largest N=2 truncation fit inside the six-torus compactification of eleven-dimensional supergravity.
Clement, María E Gabach
2015-01-01
It is well known that celestial bodies tend to be spherical due to gravity and that rotation produces deviations from this sphericity. We discuss what is known and expected about the shape of black holes' horizons from their formation to their final, stationary state. We present some recent results showing that black hole rotation indeed manifests in the widening of their central regions, limits their global shapes and enforces their whole geometry to be close to the extreme Kerr horizon geometry at almost maximal rotation speed. The results depend only on the horizon area and angular momentum. In particular they are entirely independent of the surrounding geometry of the spacetime and of the presence of matter satisfying the strong energy condition. We also discuss the the relation of this result with the Hoop conjecture.
Bender, P. [Univ. of Colorado, Boulder, CO (United States); Bloom, E. [Stanford Linear Accelerator Center, Menlo Park, CA (United States); Cominsky, L. [Sonoma State Univ., Rohnert Park, CA (United States). Dept. of Physics and Astronomy] [and others
1995-07-01
Black-hole astrophysics is not just the investigation of yet another, even if extremely remarkable type of celestial body, but a test of the correctness of the understanding of the very properties of space and time in very strong gravitational fields. Physicists` excitement at this new prospect for testing theories of fundamental processes is matched by that of astronomers at the possibility to discover and study a new and dramatically different kind of astronomical object. Here the authors review the currently known ways that black holes can be identified by their effects on their neighborhood--since, of course, the hole itself does not yield any direct evidence of its existence or information about its properties. The two most important empirical considerations are determination of masses, or lower limits thereof, of unseen companions in binary star systems, and measurement of luminosity fluctuations on very short time scales.
Bastos, C; Dias, N C; Prata, J N
2010-01-01
One considers phase-space noncommutativity in the context of a Kantowski-Sachs cosmological model to study the interior of a Schwarzschild black hole. It is shown that the potential function of the corresponding quantum cosmology problem has a local minimum. One deduces the thermodynamics and show that the Hawking temperature and entropy exhibit an explicit dependence on the momentum noncommutativity regime and it is shown that the wave function vanishes in this limit.
Noncommutative Solitonic Black Hole
Chang-Young, Ee; Kimm, Kyoungtae; Lee, Daeho; Lee, Youngone
2011-01-01
We investigate solitonic black hole solutions in three dimensional noncommutative spacetime. We do this in gravity with negative cosmological constant coupled to a scalar field. Noncommutativity is realized with the Moyal product which is expanded up to first order in the noncommutativity parameter in two spatial directions. With numerical simulation we study the effect of noncommutativity by increasing the value of the noncommutativity parameter starting from commutative solutions. We find t...
Infinitely Coloured Black Holes
Mavromatos, Nick E.; Winstanley, Elizabeth(Consortium for Fundamental Physics, School of Mathematics and Statistics, University of Sheffield, Hicks Building, Hounsfield Road, Sheffield, S3 7RH, United Kingdom)
1999-01-01
We formulate the field equations for $SU(\\infty)$ Einstein-Yang-Mills theory, and find spherically symmetric black-hole solutions. This model may be motivated by string theory considerations, given the enormous gauge symmetries which characterize string theory. The solutions simplify considerably in the presence of a negative cosmological constant, particularly for the limiting cases of a very large cosmological constant or very small gauge field. The situation of an arbitrarily small gauge f...
This book is about the life and work of Stephen Hawking. It traces the development of his theories about the universe and particularly black holes, in a biographical context. Hawking's lecture 'Is the end in sight for theoretical physics' is presented as an appendix. In this, he discusses the possibility of achieving a complete, consistent and unified theory of the physical interactions which would describe all possible observations. (U.K.)
Roberto Casadio(INFN, Bologna); Andrea Giugno; Octavian Micu; Alessio Orlandi
2015-01-01
We review some features of Bose–Einstein condensate (BEC) models of black holes obtained by means of the horizon wave function formalism. We consider the Klein–Gordon equation for a toy graviton field coupled to a static matter current in a spherically-symmetric setup. The classical field reproduces the Newtonian potential generated by the matter source, while the corresponding quantum state is given by a coherent superposition of scalar modes with a continuous occupation number. An attractiv...
Helfer, Adam D
2011-01-01
I review elements of the foundations of black-hole theory with attention to problematic issues, and describe some techniques which either seem to help with the difficulties or at least investigate their scope. The definition of black holes via event horizons has been problematic because it depends on knowing the global structure of space-time; often attempts to avoid this (e.g. apparent horizons) require knowledge of the interior geometry. I suggest studying instead the holonomy relating the exterior neighborhood of the incipient horizon to the regime of distant observers; at least in the spherically symmetric case, this holonomy will develop certain universal features, in principle observable from signals emitted from infalling objects. I discuss the theory of quantum fields in curved space-time, and the difficulties with Hawking's prediction of black-hole radiation. I then show that the usual, very natural, theory of quantum fields in curved space-time runs into difficulties when applied to measurement prob...
Lyutikov, Maxim
2011-01-01
The "no hair" theorem, a key result in General Relativity, states that an isolated black hole is defined by only three parameters: mass, angular momentum, and electric charge; this asymptotic state is reached on a light-crossing time scale. We find that the "no hair" theorem is not formally applicable for black holes formed from collapse of a rotating neutron star. Rotating neutron stars can self-produce particles via vacuum breakdown forming a highly conducting plasma magnetosphere such that magnetic field lines are effectively "frozen-in" the star both before and during collapse. In the limit of no resistivity, this introduces a topological constraint which prohibits the magnetic field from sliding off the newly-formed event horizon. As a result, during collapse of a neutron star into a black hole, the latter conserves the number of magnetic flux tubes $N_B = e \\Phi_\\infty /(\\pi c \\hbar)$, where $\\Phi_\\infty \\approx 2 \\pi^2 B_{NS} R_{NS}^3 /(P_{\\rm NS} c)$ is the initial magnetic flux through the hemisphere...
Thermal corpuscular black holes
Casadio, Roberto; Giugno, Andrea; Orlandi, Alessio
2015-06-01
We study the corpuscular model of an evaporating black hole consisting of a specific quantum state for a large number N of self-confined bosons. The single-particle spectrum contains a discrete ground state of energy m (corresponding to toy gravitons forming the black hole), and a gapless continuous spectrum (to accommodate for the Hawking radiation with energy ω >m ). Each constituent is in a superposition of the ground state and a Planckian distribution at the expected Hawking temperature in the continuum. We first find that, assuming the Hawking radiation is the leading effect of the internal scatterings, the corresponding N -particle state can be collectively described by a single-particle wave function given by a superposition of a total ground state with energy M =N m and a Planckian distribution for E >M at the same Hawking temperature. From this collective state, we compute the partition function and obtain an entropy which reproduces the usual area law with a logarithmic correction precisely related with the Hawking component. By means of the horizon wave function for the system, we finally show the backreaction of modes with ω >m reduces the Hawking flux. Both corrections, to the entropy and to the Hawking flux, suggest the evaporation properly stops for vanishing mass, if the black hole is in this particular quantum state.
Bellucci, S; Marrani, A
2008-01-01
We review recent results in the study of attractor horizon geometries (with non-vanishing Bekenstein-Hawking entropy) of dyonic extremal d=4 black holes in supergravity. We focus on N=2, d=4 ungauged supergravity coupled to a number n_{V} of Abelian vector multiplets, outlining the fundamentals of the special Kaehler geometry of the vector multiplets' scalar manifold (of complex dimension n_{V}), and studying the 1/2-BPS attractors, as well as the non-BPS (non-supersymmetric) ones with non-vanishing central charge. For symmetric special Kaehler geometries, we present the complete classification of the orbits in the symplectic representation of the classical U-duality group (spanned by the black hole charge configuration supporting the attractors), as well as of the moduli spaces of non-BPS attractors (spanned by the scalars which are not stabilized at the black hole event horizon). Finally, we report on an analogous classification for N>2-extended, d=4 ungauged supergravities, in which also the 1/N-BPS attrac...
Non-Abelian magnetic black strings versus black holes
Mazharimousavi, S. Habib; Halilsoy, M.
2016-05-01
We present d+1 -dimensional pure magnetic Yang-Mills (YM) black strings (or 1-branes) induced by the d -dimensional Einstein-Yang-Mills-Dilaton black holes. The Born-Infeld version of the YM field makes our starting point which goes to the standard YM field through a limiting procedure. The lifting from black holes to black strings (with less number of fields) is done by adding an extra, compact coordinate. This amounts to the change of horizon topology from S^{d-2} to a product structure. Our black string in 5 dimensions is a rather special one, with uniform Hawking temperature and non-asymptotically flat structure. As the YM charge becomes large the string gets thinner to tend into a breaking point and transform into a 4-dimensional black hole.
Emanuel, K.; Lin, N.
2012-12-01
Virtually all assessments of tropical cyclone risk are based on historical records, which are limited to a few hundred years at most. Yet stronger TCs may occur in the future and at places that have not been affected historically. Such events lie outside the realm of historically based expectations and may have extreme impacts. Their occurrences are also often made explainable after the fact (e.g., Hurricane Katrina). We nickname such potential future TCs, characterized by rarity, extreme impact, and retrospective predictability, "black swans" (Nassim Nicholas Taleb, 2007). As, by definition, black swan TCs have yet to happen, statistical methods that solely rely on historical track data cannot predict their occurrence. Global climate models lack the capability to predict intense storms, even with a resolution as high as 14 km (Emanuel et al. 2010). Also, most dynamic downscaling methods (e.g., Bender et al. 2010) are still limited in horizontal resolution and are too expensive to implement to generate enough events to include rare ones. In this study, we apply a simpler statistical/deterministic hurricane model (Emanuel et al. 2006) to simulate large numbers of synthetic storms under a given (observed or projected) climate condition. The method has been shown to generate realistic extremes in various basins (Emanuel et al. 2008 and 2010). We also apply a hydrodynamic model (ADCIRC; Luettich et al. 1992) to simulate the storm surges generated by these storms. We then search for black swan TCs, in terms of the joint wind and surge damage potential, in the generated large databases. Heavy rainfall is another important TC hazard and will be considered in a future study. We focus on three areas: Tampa Bay in the U.S., the Persian Gulf, and Darwin in Australia. Tampa Bay is highly vulnerable to storm surge as it is surrounded by shallow water and low-lying lands, much of which may be inundated by a storm tide of 6 m. High surges are generated by storms with a broad
Stimulated emission and black holes
The probability of a black hole emitting m particles when n particles are incident on the black hole was first derived by Bekenstein and Meisels, and later, using a different method, by Panangaden and Wald. In another paper by Bekenstein, it was argued that black holes should have stimulated emission in all modes including the nonsuperradiant ones. In this paper, we use a model based on quantum field theory. We show that Bose-Einstein statistics enhances the probability for particles to scatter in the same direction. We also prove that a black hole is equivalent to a perfect blackbody surrounded by a mirror. In our model, the black hole does not exhibit stimulated emission in nonsuperradiant modes. We also compare the black hole to a gray body
Dvali, Gia
2013-01-01
According to the standard view classically black holes carry no hair, whereas quantum hair is at best exponentially weak. We show that suppression of hair is an artifact of the semi-classical treatment and that in the quantum picture hair appears as an inverse mass-square effect. Such hair is predicted in the microscopic quantum description in which a black hole represents a self-sustained leaky Bose-condensate of N soft gravitons. In this picture the Hawking radiation is the quantum depletion of the condensate. Within this picture we show that quantum black hole physics is fully compatible with continuous global symmetries and that global hair appears with the strength B/N, where B is the global charge swallowed by the black hole. For large charge this hair has dramatic effect on black hole dynamics. Our findings can have interesting astrophysical consequences, such as existence of black holes with large detectable baryonic and leptonic numbers.
Black Hole Masses are Quantized
Dvali, Gia; Mukhanov, Slava
2011-01-01
We give a simple argument showing that in any sensible quantum field theory the masses of black holes cannot assume continuous values and must be quantized. Our proof solely relies on Poincare-invariance of the asymptotic background, and is insensitive to geometric characteristics of black holes or other peculiarities of the short distance physics. Therefore, our results are equally-applicable to any other localized objects on asymptotically Poincare-invariant space, such as classicalons. By adding a requirement that in large mass limit the quantization must approximately account for classical results, we derive an universal quantization rule applicable to all classicalons (including black holes) in arbitrary number of dimensions. In particular, this implies, that black holes cannot emit/absorb arbitrarily soft quanta. The effect has phenomenological model-independent implications for black holes and other classicalons that may be created at LHC. We predict, that contrary to naive intuition, the black holes a...
According to the standard view classically black holes carry no hair, whereas quantum hair is at best exponentially weak. We show that suppression of hair is an artifact of the semi-classical treatment and that in the quantum picture hair appears as an inverse mass-square effect. Such hair is predicted in the microscopic quantum description in which a black hole represents a self-sustained leaky Bose-condensate of N soft gravitons. In this picture the Hawking radiation is the quantum depletion of the condensate. Within this picture we show that quantum black hole physics is fully compatible with continuous global symmetries and that global hair appears with the strength B/N, where B is the global charge swallowed by the black hole. For large charge this hair has dramatic effect on black hole dynamics. Our findings can have interesting astrophysical consequences, such as existence of black holes with large detectable baryonic and leptonic numbers
Small black holes on cylinders
We find the metric of small black holes on cylinders, i.e. neutral and static black holes with a small mass in d-dimensional Minkowski space times a circle. The metric is found using an ansatz for black holes on cylinders proposed in J. High Energy Phys. 05, 032 (2002). We use the new metric to compute corrections to the thermodynamics which is seen to deviate from that of the (d+1)-dimensional Schwarzschild black hole. Moreover, we compute the leading correction to the relative binding energy which is found to be non-zero. We discuss the consequences of these results for the general understanding of black holes and we connect the results to the phase structure of black holes and strings on cylinders
Information Storage in Black Holes
Maia, M. D.
2005-01-01
The information loss paradox for Schwarzschild black holes is examined, using the ADS/CFT correspondence extended to the $M_6 (4,2)$ bulk. It is found that the only option compatible with the preservation of the quantum unitarity is when a regular remnant region of the black hole survives to the black hole evaporation process, where information can be stored and eventually retrieved.
Origin of supermassive black holes
Dokuchaev, V. I.; Eroshenko, Yu. N.; Rubin, S. G.
2007-01-01
The origin of supermassive black holes in the galactic nuclei is quite uncertain in spite of extensive set of observational data. We review the known scenarios of galactic and cosmological formation of supermassive black holes. The common drawback of galactic scenarios is a lack of time and shortage of matter supply for building the supermassive black holes in all galaxies by means of accretion and merging. The cosmological scenarios are only fragmentarily developed but propose and pretend to...
In this talk, I present and discuss a number of attempts to construct black hole solutions in models with Warped Extra Dimensions. Then, a contact is made with models with Large Extra Dimensions, where black-hole solutions are easily constructed - here the focus will be on the properties of microscopic black holes and the possibility of using phenomena associated with them, such as the emission of Hawking radiation, to discover fundamental properties of our spacetime.
Black holes and the multiverse
Garriga, Jaume; Vilenkin, Alexander; Zhang, Jun
2016-02-01
Vacuum bubbles may nucleate and expand during the inflationary epoch in the early universe. After inflation ends, the bubbles quickly dissipate their kinetic energy; they come to rest with respect to the Hubble flow and eventually form black holes. The fate of the bubble itself depends on the resulting black hole mass. If the mass is smaller than a certain critical value, the bubble collapses to a singularity. Otherwise, the bubble interior inflates, forming a baby universe, which is connected to the exterior FRW region by a wormhole. A similar black hole formation mechanism operates for spherical domain walls nucleating during inflation. As an illustrative example, we studied the black hole mass spectrum in the domain wall scenario, assuming that domain walls interact with matter only gravitationally. Our results indicate that, depending on the model parameters, black holes produced in this scenario can have significant astrophysical effects and can even serve as dark matter or as seeds for supermassive black holes. The mechanism of black hole formation described in this paper is very generic and has important implications for the global structure of the universe. Baby universes inside super-critical black holes inflate eternally and nucleate bubbles of all vacua allowed by the underlying particle physics. The resulting multiverse has a very non-trivial spacetime structure, with a multitude of eternally inflating regions connected by wormholes. If a black hole population with the predicted mass spectrum is discovered, it could be regarded as evidence for inflation and for the existence of a multiverse.
Statistical Hair on Black Holes
The Bekenstein-Hawking entropy for certain BPS-saturated black holes in string theory has recently been derived by counting internal black hole microstates at weak coupling. We argue that the black hole microstate can be measured by interference experiments even in the strong coupling region where there is clearly an event horizon. Extracting information which is naively behind the event horizon is possible due to the existence of statistical quantum hair carried by the black hole. This quantum hair arises from the arbitrarily large number of discrete gauge symmetries present in string theory. copyright 1996 The American Physical Society
Pyrolytic carbon coated black silicon.
Shah, Ali; Stenberg, Petri; Karvonen, Lasse; Ali, Rizwan; Honkanen, Seppo; Lipsanen, Harri; Peyghambarian, N; Kuittinen, Markku; Svirko, Yuri; Kaplas, Tommi
2016-01-01
Carbon is the most well-known black material in the history of man. Throughout the centuries, carbon has been used as a black material for paintings, camouflage, and optics. Although, the techniques to make other black surfaces have evolved and become more sophisticated with time, carbon still remains one of the best black materials. Another well-known black surface is black silicon, reflecting less than 0.5% of incident light in visible spectral range but becomes a highly reflecting surface in wavelengths above 1000 nm. On the other hand, carbon absorbs at those and longer wavelengths. Thus, it is possible to combine black silicon with carbon to create an artificial material with very low reflectivity over a wide spectral range. Here we report our results on coating conformally black silicon substrate with amorphous pyrolytic carbon. We present a superior black surface with reflectance of light less than 0.5% in the spectral range of 350 nm to 2000 nm. PMID:27174890
Higher dimensional extremal black strings
H. W. Lee; Myung, Y. S.; Kim, Jin Young; Park, D. K.
1996-01-01
We investigate the five and six-dimensional black strings within Einstein-Maxwell theory. The extremal black strings are endowed with the null Killing symmetry. We study the propagation of Einstein-Maxwell modes in the extremal black string background by using this symmetry. It turns out that one graviton is a propagating mode, while both the Maxwell $F$ and three-form $H$ fields are non-propagating modes. Further we discuss the stability and classical hair of the extremal black strings.
How black holes saved relativity
Prescod-Weinstein, Chanda
2016-02-01
While there have been many popular-science books on the historical and scientific legacy of Albert Einstein's general theory of relativity, a gap exists in the literature for a definitive, accessible history of the theory's most famous offshoot: black holes. In Black Hole, the science writer Marcia Bartusiak aims for a discursive middle ground, writing solely about black holes at a level suitable for both high-school students and more mature readers while also giving some broader scientific context for black-hole research.
In 1984, the Black Report published its results on the incidence of cancer and leukaemia in under 25-year olds in the village of Seascale and the surrounding area near the Sellafield nuclear reprocessing plant. Since then the pressure group core, as a result of their own independent research, has discovered ten additional cases of childhood cancer which should have been included in the Black Report and a Further two cases since the Black Report was written. This represents an additional 31% over the initial numbers considered and a review of the Black Report is sought. (UK)
Thermodynamics of Accelerating Black Holes
Appels, Michael; Kubiznak, David
2016-01-01
We address a long-standing problem of describing the thermodynamics of a charged accelerating black hole. We derive a standard first law of black hole thermodynamics, with the usual identification of entropy proportional to the area of the event horizon -- even though the event horizon contains a conical singularity. This result not only extends the applicability of black hole thermodynamics to realms previously not anticipated, it also opens a possibility for studying novel properties of an important class of exact radiative solutions of Einstein equations describing accelerated objects. We discuss the thermodynamic volume, stability and phase structure of these black holes.
Casadio, Roberto; Giugno, Andrea; Micu, Octavian; Orlandi, Alessio
2015-10-01
We review some features of BEC models of black holes obtained by means of the HWF formalism. We consider the KG equation for a toy graviton field coupled to a static matter current in spherical symmetry. The classical field reproduces the Newtonian potential generated by the matter source, while the corresponding quantum state is given by a coherent superposition of scalar modes with continuous occupation number. An attractive self-interaction is needed for bound states to form, so that (approximately) one mode is allowed, and the system of N bosons can be self-confined in a volume of the size of the Schwarzschild radius. The HWF is then used to show that the radius of such a system corresponds to a proper horizon. The uncertainty in the size of the horizon is related to the typical energy of Hawking modes: it decreases with the increasing of the black hole mass (larger number of gravitons), in agreement with semiclassical calculations and different from a single very massive particle. The spectrum contains a discrete ground state of energy $m$ (the bosons forming the black hole), and a continuous spectrum with energy $\\omega > m$ (representing the Hawking radiation and modelled with a Planckian distribution at the expected Hawking temperature). The $N$-particle state can be collectively described by a single-particle wave-function given by a superposition of a total ground state with energy $M = N m$ and a Planckian distribution for $E > M$ at the same Hawking temperature. The partition function is then found to yield the usual area law for the entropy, with a logarithmic correction related with the Hawking component. The backreaction of modes with $\\omega > m$ is also shown to reduce the Hawking flux and the evaporation properly stops for vanishing mass.
Armen Yeranyan
2008-10-01
Full Text Available The general solutions of the radial attractor flow equations for extremal black holes, both for non-BPS with non-vanishing central charge Z and for Z = 0, are obtained for the so-called stu model, the minimal rank-3 N = 2 symmetric supergravity in d = 4 space-time dimensions. Comparisons with previous partial results, as well as the fake supergravity (first order formalism and an analysis of the marginal stability of corresponding D-brane configurations, are given.
Bastos, C.; Bertolami, O.; Dias, N. C.; Prata, J. N.
2010-04-01
One considers phase-space noncommutativity in the context of a Kantowski-Sachs cosmological model to study the interior of a Schwarzschild black hole. It is shown that the potential function of the corresponding quantum cosmology problem has a local minimum. One deduces the thermodynamics and show that the Hawking temperature and entropy exhibit an explicit dependence on the momentum noncommutativity parameter, η. Furthermore, the t = r = 0 singularity is analysed in the noncommutative regime and it is shown that the wave function vanishes in this limit.
Bastos, C; Bertolami, O [Departamento de Fisica, Instituto Superior Tecnico, Avenida Rovisco Pais 1, 1049-001 Lisboa (Portugal); Dias, N C; Prata, J N, E-mail: cbastos@fisica.ist.utl.p, E-mail: orfeu@cosmos.ist.utl.p, E-mail: ncdias@mail.telepac.p, E-mail: joao.prata@mail.telepac.p [Departamento de Matematica, Universidade Lusofona de Humanidades e Tecnologias, Avenida Campo Grande, 376, 1749-024 Lisboa (Portugal)
2010-04-01
One considers phase-space noncommutativity in the context of a Kantowski-Sachs cosmological model to study the interior of a Schwarzschild black hole. It is shown that the potential function of the corresponding quantum cosmology problem has a local minimum. One deduces the thermodynamics and show that the Hawking temperature and entropy exhibit an explicit dependence on the momentum noncommutativity parameter, {eta}. Furthermore, the t = r = 0 singularity is analysed in the noncommutative regime and it is shown that the wave function vanishes in this limit.
One considers phase-space noncommutativity in the context of a Kantowski-Sachs cosmological model to study the interior of a Schwarzschild black hole. It is shown that the potential function of the corresponding quantum cosmology problem has a local minimum. One deduces the thermodynamics and show that the Hawking temperature and entropy exhibit an explicit dependence on the momentum noncommutativity parameter, η. Furthermore, the t = r = 0 singularity is analysed in the noncommutative regime and it is shown that the wave function vanishes in this limit.
Roberto Casadio
2015-10-01
Full Text Available We review some features of Bose–Einstein condensate (BEC models of black holes obtained by means of the horizon wave function formalism. We consider the Klein–Gordon equation for a toy graviton field coupled to a static matter current in a spherically-symmetric setup. The classical field reproduces the Newtonian potential generated by the matter source, while the corresponding quantum state is given by a coherent superposition of scalar modes with a continuous occupation number. An attractive self-interaction is needed for bound states to form, the case in which one finds that (approximately one mode is allowed, and the system of N bosons can be self-confined in a volume of the size of the Schwarzschild radius. The horizon wave function formalism is then used to show that the radius of such a system corresponds to a proper horizon. The uncertainty in the size of the horizon is related to the typical energy of Hawking modes: it decreases with the increasing of the black hole mass (larger number of gravitons, resulting in agreement with the semiclassical calculations and which does not hold for a single very massive particle. The spectrum of these systems has two components: a discrete ground state of energy m (the bosons forming the black hole and a continuous spectrum with energy ω > m (representing the Hawking radiation and modeled with a Planckian distribution at the expected Hawking temperature. Assuming the main effect of the internal scatterings is the Hawking radiation, the N-particle state can be collectively described by a single-particle wave-function given by a superposition of a total ground state with energy M = Nm and Entropy 2015, 17 6894 a Planckian distribution for E > M at the same Hawking temperature. This can be used to compute the partition function and to find the usual area law for the entropy, with a logarithmic correction related to the Hawking component. The backreaction of modes with ω > m is also shown to reduce
Pezoldt, Joerg [FG Nanotechnologie, Institut fuer Mikro- und Nanotechnologie, TU Ilmenau, Postfach 100565, 98684 Ilmenau (Germany); Kups, Thomas [FG Werkstoffe der Elektrotechnik, Institut fuer Mikro- und Nanotechnologien, TU Ilmenau, Postfach 1005765, 98684 Ilmenau (Germany); Stubenrauch, Mike [FG Mikromechanische Systeme, Institut fuer Mikro- und Nanotechnologien, TU Ilmenau, Postfach 1005765, 98684 Ilmenau (Germany); Fischer, Michael [FG Elektroniktechnologie, Institut fuer Mikro- und Nanotechnologien, TU Ilmenau, Postfach 1005765, 98684 Ilmenau (Germany)
2011-03-15
Black silicon is a fascinating multipurpose modification of bulk silicon which can be fabricated in a selforganized structure formation process during dry etching of bare silicon wafer leading to the formation of a high density of silicon needles. The smallest dimension of the tips approaches values between 1 and 2 nm. The silicon nanostructure exhibits an extremely low diffuse reflectivity. The nanosized tips and their coating with fluorine doped nonstoichiometric silicon dioxide are responsible for cathodoluminescence in the blue-green and red regions of the visible spectra (copyright 2011 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim) (orig.)
Holographic Black Hole Chemistry
Karch, Andreas
2015-01-01
Thermodynamic quantities associated with black holes in Anti-de Sitter space obey an interesting identity when the cosmological constant is included as one of the dynamical variables, the generalized Smarr relation. We show that this relation can easily be understood from the point of view of the dual holographic field theory. It amounts to the simple statement that the extensive thermodynamic quantities of a large $N$ gauge theory only depend on the number of colors, $N$, via an overall factor of $N^2$.
Black Holes, Black Swans, Black Magic: the Emerging Arts of Project Execution
Prieto, Bob
2013-01-01
Fluor Corporation executive to give Vecellio LectureBlacksburg, VA , September 16, 2013 Virginia Tech College of Engineering Bob Prieto, senior vice president, Fluor Corporation, will present the 2013 Vecellio Distinguished Lecture, titled “Black Holes, Black Swans, Black Magic: the Emerging Arts of Project Execution,” on Friday, Oct. 11 at 4 p.m. in Torgersen 2150. His talk will provide a whirlwind tour of some of the growing challenges in construction project execution and some of the emerg...
2002-10-01
Star Orbiting Massive Milky Way Centre Approaches to within 17 Light-Hours [1] Summary An international team of astronomers [2], lead by researchers at the Max-Planck Institute for Extraterrestrial Physics (MPE) , has directly observed an otherwise normal star orbiting the supermassive black hole at the center of the Milky Way Galaxy. Ten years of painstaking measurements have been crowned by a series of unique images obtained by the Adaptive Optics (AO) NAOS-CONICA (NACO) instrument [3] on the 8.2-m VLT YEPUN telescope at the ESO Paranal Observatory. It turns out that earlier this year the star approached the central Black Hole to within 17 light-hours - only three times the distance between the Sun and planet Pluto - while travelling at no less than 5000 km/sec . Previous measurements of the velocities of stars near the center of the Milky Way and variable X-ray emission from this area have provided the strongest evidence so far of the existence of a central Black Hole in our home galaxy and, implicitly, that the dark mass concentrations seen in many nuclei of other galaxies probably are also supermassive black holes. However, it has not yet been possible to exclude several alternative configurations. In a break-through paper appearing in the research journal Nature on October 17th, 2002, the present team reports their exciting results, including high-resolution images that allow tracing two-thirds of the orbit of a star designated "S2" . It is currently the closest observable star to the compact radio source and massive black hole candidate "SgrA*" ("Sagittarius A") at the very center of the Milky Way. The orbital period is just over 15 years. The new measurements exclude with high confidence that the central dark mass consists of a cluster of unusual stars or elementary particles, and leave little doubt of the presence of a supermassive black hole at the centre of the galaxy in which we live . PR Photo 23a/02 : NACO image of the central region of the Milky Way
Area spectrum of slowly rotating black holes
Myung, Yun Soo
2010-01-01
We investigate the area spectrum for rotating black holes which are Kerr and BTZ black holes. For slowly rotating black holes, we use the Maggiore's idea combined with Kunstatter's method to derive their area spectra, which are equally spaced.
Spacetime Duality of BTZ Black Hole
Ho, Jeongwon; Kim, Won T.; Park, Young-Jai
1999-01-01
We consider the duality of the quasilocal black hole thermodynamics, explicitly the quasilocal black hole thermodynamic first law, in BTZ black hole solution as a special one of the three-dimensional low energy effective string theory.
Stability and critical phenomena of black holes and black rings
We revisit the general topic of thermodynamical stability and critical phenomena in black hole physics, analyzing in detail the phase diagram of the five dimensional rotating black hole and the black rings discovered by Emparan and Reall. First we address the issue of microcanonical stability of these spacetimes and its relation to thermodynamics by using the so-called Poincare (or 'turning point') method, which we review in detail. We are able to prove that one of the black ring branches is always locally unstable, showing that there is a change of stability at the point where the two black ring branches meet. Next we study divergence of fluctuations, the geometry of the thermodynamic state space (Ruppeiner geometry) and compute the appropriate critical exponents and verify the scaling laws familiar from renormalization group theory in statistical mechanics. We find that, at extremality, the behavior of the system is formally very similar to a second order phase transition
Supersymmetric black holes in string theory
Mohaupt, T.
2007-01-01
We review recent developments concerning supersymmetric black holes in string theory. After a general introduction to the laws of black hole mechanics and to black hole entropy in string theory, we discuss black hole solutions in N=2 supergravity, special geometry, the black hole attractor equations and the underlying variational principle. Special attention is payed to the crucial role of higher derivative corrections. Finally we discuss black hole partition functions and their relation to t...
Casadio, Roberto; Micu, Octavian; Orlandi, Alessio
2015-01-01
We review some features of BEC models of black holes obtained by means of the HWF formalism. We consider the KG equation for a toy graviton field coupled to a static matter current in spherical symmetry. The classical field reproduces the Newtonian potential generated by the matter source, while the corresponding quantum state is given by a coherent superposition of scalar modes with continuous occupation number. An attractive self-interaction is needed for bound states to form, so that (approximately) one mode is allowed, and the system of N bosons can be self-confined in a volume of the size of the Schwarzschild radius. The HWF is then used to show that the radius of such a system corresponds to a proper horizon. The uncertainty in the size of the horizon is related to the typical energy of Hawking modes: it decreases with the increasing of the black hole mass (larger number of gravitons), in agreement with semiclassical calculations and different from a single very massive particle. The spectrum contains a...
Thermal corpuscular black holes
Casadio, Roberto; Orlandi, Alessio
2015-01-01
We study the corpuscular model of an evaporating black hole consisting of a specific quantum state for a large number $N$ of self-confined bosons. The single-particle spectrum contains a discrete ground state of energy $m$ (corresponding to toy gravitons forming the black hole), and a gapless continuous spectrum (to accommodate for the Hawking radiation with energy $\\omega>m$). Each constituent is in a superposition of the ground state and a Planckian distribution at the expected Hawking temperature in the continuum. We first find that, assuming the Hawking radiation is the leading effect of the internal scatterings, the corresponding $N$-particle state can be collectively described by a single-particle wave-function given by a superposition of a total ground state with energy $M=N\\,m$ and a Planckian distribution for $E>M$ at the same Hawking temperature. From this collective state, we compute the partition function and obtain an entropy which reproduces the usual area law with a logarithmic correction preci...
Hawking, Stephen William
1996-01-01
One would expect spacetime to have a foam-like structure on the Planck scale with a very high topology. If spacetime is simply connected (which is assumed in this paper), the non-trivial homology occurs in dimension two, and spacetime can be regarded as being essentially the topological sum of S^2\\times S^2 and K3 bubbles. Comparison with the instantons for pair creation of black holes shows that the S^2\\times S^2 bubbles can be interpreted as closed loops of virtual black holes. It is shown that scattering in such topological fluctuations leads to loss of quantum coherence, or in other words, to a superscattering matrix \\ that does not factorise into an S matrix and its adjoint. This loss of quantum coherence is very small at low energies for everything except scalar fields, leading to the prediction that we may never observe the Higgs particle. Another possible observational consequence may be that the \\theta angle of QCD is zero without having to invoke the problematical existence of a light axion. The pic...
Black hole thermodynamical entropy
Tsallis, Constantino [Centro Brasileiro de Pesquisas Fisicas and National Institute of Science and Technology for Complex Systems, Rio de Janeiro, RJ (Brazil); Santa Fe Institute, Santa Fe, NM (United States); Cirto, Leonardo J.L. [Centro Brasileiro de Pesquisas Fisicas and National Institute of Science and Technology for Complex Systems, Rio de Janeiro, RJ (Brazil)
2013-07-15
As early as 1902, Gibbs pointed out that systems whose partition function diverges, e.g. gravitation, lie outside the validity of the Boltzmann-Gibbs (BG) theory. Consistently, since the pioneering Bekenstein-Hawking results, physically meaningful evidence (e.g., the holographic principle) has accumulated that the BG entropy S{sub BG} of a (3+1) black hole is proportional to its area L{sup 2} (L being a characteristic linear length), and not to its volume L{sup 3}. Similarly it exists the area law, so named because, for a wide class of strongly quantum-entangled d-dimensional systems, S{sub BG} is proportional to lnL if d=1, and to L{sup d-1} if d>1, instead of being proportional to L{sup d} (d {>=} 1). These results violate the extensivity of the thermodynamical entropy of a d-dimensional system. This thermodynamical inconsistency disappears if we realize that the thermodynamical entropy of such nonstandard systems is not to be identified with the BG additive entropy but with appropriately generalized nonadditive entropies. Indeed, the celebrated usefulness of the BG entropy is founded on hypothesis such as relatively weak probabilistic correlations (and their connections to ergodicity, which by no means can be assumed as a general rule of nature). Here we introduce a generalized entropy which, for the Schwarzschild black hole and the area law, can solve the thermodynamic puzzle. (orig.)
Belloni, T M
2016-01-01
The last two decades have seen a great improvement in our understand- ing of the complex phenomenology observed in transient black-hole binary systems, especially thanks to the activity of the Rossi X-Ray Timing Explorer satellite, com- plemented by observations from many other X-ray observatories and ground-based radio, optical and infrared facilities. Accretion alone cannot describe accurately the intricate behavior associated with black-hole transients and it is now clear that the role played by different kinds of (often massive) outflows seen at different phases of the outburst evolution of these systems is as fundamental as the one played by the accretion process itself. The spectral-timing states originally identified in the X-rays and fundamentally based on the observed effect of accretion, have acquired new importance as they now allow to describe within a coherent picture the phenomenology observed at other wave- length, where the effects of ejection processes are most evident. With a particular focu...