Stochastic Methods in Biology

CERN Document Server

Kallianpur, Gopinath; Hida, Takeyuki

1987-01-01

The use of probabilistic methods in the biological sciences has been so well established by now that mathematical biology is regarded by many as a distinct dis­ cipline with its own repertoire of techniques. The purpose of the Workshop on sto­ chastic methods in biology held at Nagoya University during the week of July 8-12, 1985, was to enable biologists and probabilists from Japan and the U. S. to discuss the latest developments in their respective fields and to exchange ideas on the ap­ plicability of the more recent developments in stochastic process theory to problems in biology. Eighteen papers were presented at the Workshop and have been grouped under the following headings: I. Population genetics (five papers) II. Measure valued diffusion processes related to population genetics (three papers) III. Neurophysiology (two papers) IV. Fluctuation in living cells (two papers) V. Mathematical methods related to other problems in biology, epidemiology, population dynamics, etc. (six papers) An important f...

Standardization, IPRs and open innovation in synthetic biology

DEFF Research Database (Denmark)

Minssen, Timo; Wested, Jakob

2015-01-01

various technical areas, and also the basic processes of standard creation can be divided into various categories. The different technical areas and processes for standardization differ in their speed, handling of interests and ability to dodge possible IPR concerns. Out of this notion arise i.......a. the following questions: How comparable is engineering in SB to more traditional fields of engineering?; What type of standards have emerged and what bearing have IPRs on these?; and, How applicable are the approaches adopted by the standards-setting organizations in the information and communication technology...... (ICT) to biological standards? These and further legal issues related to IP, regulation, standardization, competition law & open innovation require a careful consideration of new user-generated models and solutions. Before this background this paper seeks to describe IP and standardization aspects...

Forms and Methods of Agricultural Sector Innovative Activity Improvement

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Aisha S. Ablyaeva

2013-01-01

Full Text Available The article is focused on basic forms and methods to improve the efficiency of innovative activity in the agricultural sector of Ukraine. It was determined that the development of agriculture in Ukraine is affected by a number of factors that must be considered to design innovative models of entrepreneurship development and ways to improve the efficiency of innovative entrepreneurship activity.

TRANSFORMATION OF INNOVATIVE AND METHODICAL ACTIVITY LIBRARY OF THE UNIVERSITY

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О. О. Скаченко

2015-09-01

Full Text Available The purpose of our article is the analysis of innovative and methodical activity of university libraries which develop as information centers today. The subject of research is methodical, publishing and innovative activity of Scientific Library of the Kiev national university of culture and arts. We observe process of introduction of technological innovations in library service that allows improving quality of the services provided to the reader by library. New actual projects are developed, cultural and educational and information services extend, work methods improve. Also, the structure of library is improved – there are new sectors. The main finding of the work consists in systematization of various aspects and the directions of innovative activity of library. The research findings have the practical value for library workers, teachers of university, students, library users, and also for anyone who is interested in library science.

APPLICATION OF QUALITY ECONOMY METHODS IN MANAGING INNOVATION CAPACITY DEVELOPMENT

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V. V. Okrepilov

2017-01-01

Full Text Available Purpose: to reveal the possibilities of applying the methods of the quality economy to improve the management efficiency of the development of the region's innovative potential.Results: in the article topical questions of development of innovative potential of the region are considered - one of the important factors providing improvement of quality of life of the population and sustainable development of the territory. The content of the concept of "innovation potential of the region" is disclosed and its components are described. The purposes of development of innovative potential are considered. A comparative analysis of the methods of managing the development of potential in the market and planned economy is carried out. Particular attention is paid to the application of quality management methods to improve management effectiveness. In conclusion, the advantages and disadvantages of the economy of the macro-region "North-West" from the point of view of transition to an innovative development path, as well as scenarios for the development of the economy, are discussed.Conclusions and relevance: the use of quality economy tools to manage the development of innovative capacity will help to avoid mistakes and choose the right directions for development. In the era of globalization, improving quality is a prerequisite for successful competition in world markets. Therefore, the issues of innovation capacity assessment should be taken into account in the development of regional plans and programs, as well as socio-economic policy.

Development of Methods of Innovative Projects’ Management in Developer Organizations

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Papelniuk Oksana

2017-01-01

Full Text Available In article the author studies the conceptual scheme of life cycle of innovative developer project and offers methods of innovative projects' management according to the stages of its lifecycle. The author describes algorithm of the organization of management system of innovative projects in the developer organization representing set of stages and methods. The offered algorithm allows developer organizations achieve one of the main of their objectives, which is the creation of a special environment of comfortable accommodation with the emphasis on ecological compatibility and energy efficiency.

The Methodical Approaches to Activation of Innovative Potential of Enterprise

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Berveno Oksana V.

2017-12-01

Full Text Available The article is aimed at developing theoretical provisions and practical recommendations on methods of management and activation of innovative potential of enterprises. Assessment of innovative potential of enterprise should be carried out from different positions, taking into consideration all external and internal possibilities of enterprise as to carrying out an innovation activity. The system of management of innovation activity and implementation of innovative potential at enterprise should be closely woven in the general management of the enterprise. Activation of innovative potential of enterprise foresees adoption of the whole system of strategic decisions, which are aimed at creation of the most favorable conditions for implementation of innovative potential with obtaining of planned results. The system of activization of innovative potential should develop a number of organizational decisions on interaction of elements of the most innovative potential in the process of innovation activity and cooperation of innovative potential with other subsystems of the enterprise. Results of these organizational decisions in many respects determine efficiency of innovation activity of the enterprise.

THE RISKS’ ASSESSMENT IN INNOVATIVE PROJECTS BY THE METHOD OF VERIFIED EQUIVALENTS

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Анатолій Валентинович ШАХОВ

2017-03-01

Full Text Available The article describes the concept of "risk of innovation", identified the causes of the risk and the methods of eliminating of negative manifestations of the risk situations in innovative projects. The advantages and disadvantages of the method of correction of the discount rate and the method of equivalent annuities are considered. The methodical approach in assessing the expected effect of the innovative project based on the concept of probability-interval uncertainty is proposed in the article. It was established that the analyzed approaches can be used for the accounting of the risk of innovative projects. Project manager makes his choice using any method of risk assessment individually, depending on the extent and characteristics of the project, the degree of novelty and scale introduction of innovative products, the number of participants and the level of requirements of the foundation of project efficiency and other factors.

Challenges in biomimetic design and innovation

DEFF Research Database (Denmark)

Lenau, Torben Anker; Barfoed, Michael; Shu, Li

Biomimetic design copies desired principles found in nature and implement them into artificial applications. Applications could be products we use in our daily life but it can also be used to inspire material innovation. However there are significant challenges in performing biomimetic design. One....... This is a key issue in design and innovation work where problem identification and systematic search for suitable solution principle are major activities. One way to deal with this challenge is to use a biology search method. The use of such a method is illustrated with a case story describing the design...... including the terminology and knowledge organisation. It is often easy to recognise the splendour of a biological solution, but it can be much more difficult to understand the underlying mechanisms. Another challenge in biomimetic design is the search and identification of relevant solutions in nature...

IMPROVED METHODS FOR EVALUATING THE EFFECTIVENESS OF INNOVATION DEVELOPMENT IN RUSSIAN CORPORATIONS

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E. L. Dorzhieva

2016-01-01

Full Text Available Objectives. Innovative activity is a key factor in the effective development and growth of competitiveness in the Russian economy. An important role in this process is played by industrial corporations. Against this background, there is an increased need for improving the effectiveness of methods for evaluating the innovation development of Russian corporations. Methods. Formal logic as well as system analysis methods were used in the research, allowing us to consider the corporation as a system that includes a variety of innovational directions (elements. Results. The article discusses various approaches to the determination of the basic definitions of innovation; a classification of innovation is proposed. The attributes of innovative activity of industrial corporations are distinguished together with an outline of the possible causes of various innovative corporate activities; components of the system of indicators of innovation activity are isolated: financial; consumer; process; development and training; risk management. The need for the indices of the innovation activity of the risk component to be included in the composition of the system is substantiated. It is shown how the objectives for each area of innovation may be achieved in tandem with a methodological approach that allows continuous monitoring of the implementation of innovative development strategies. An algorithm for evaluating the implementation of innovative strategies contributing to the development of industrial corporations is presented. Conclusion. Theoretical and methodological development can be used not only to navigate the variety of innovations but also to determine and establish the relationship and interdependence between the various innovations as well as carry out analysis, assessment and forecasting for the effective development of innovative activity of Russian corporations. 

Innovative biological systems for anaerobic treatment of grain and food processing wastewaters

Energy Technology Data Exchange (ETDEWEB)

Sutton, P M

1986-09-01

The application of two innovative fixed film and suspended growth anaerobic biological systems to the treatment of grain and food processing wastewaters is discussed. A fluidized bed fixed film system and a suspended growth membrane system are described. The technical and economic factors dictating which system is selected for treatment of a specific industrial wastewater are discussed. Case history results from successful operation of full-scale, demonstration, and pilot-scale systems treating respectively, soy whey, cheese whey, and wheat flour processing wastewaters are presented.

Participatory methods for initiating manufacturing employees' involvement in product innovation

DEFF Research Database (Denmark)

Jensen, Anna Rose Vagn; Jensen, Christian Schou; Broberg, Ole

2016-01-01

approach that we apply to two case companies, this paper presents an empirical study of how to initiate involvement of manufacturing employees in R&D activities. We have used participatory methods from design thinking that has the ability to create relations between employees from different backgrounds......Employee-driven innovation has the potential to improve product innovation by involving employees as innovative resources. However, it can be a challenge to turn the potential into a reality of collaboration practices across organizational structures and culture. Through an interactive research...... and through a series of facilitated workshops we have investigated how these methods can initiate employee involvement. We see that participatory methods can improve understanding and relation between R&D and manufacturing departments, and thereby support a creative collaboration and emergence of employee...

Proposition of a method to formulate idea and innovation problems

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Stéphane GORIA

2010-01-01

Full Text Available Nowadays, innovation is a major stake for development and durability of many companies and institution’s activities. In our work, we are interested in interpersonal communication problem in innovation context. We focus on the upstream of innovation process and we consider the means that can be used. First to leverage organisation’s innovation perspective and second to solve innovation problem proposed by a strategic decision maker. To do this, we believe that people charge with solving an innovation problem should manage some difficulties: to identify what can be an innovation for the decision maker, to define the objects with a big innovation potential, communicate to his possible partners the innovation field to investigate and to find ideas to innovate etc. Then, we try to identify and to present these ideas to contribute to decision making process. At this time when the Web is really the universal source with access to formidable information quantities, we use it to establish some creativity and idea sources for innovation. This paper presents a method to solve these communication problems. It presents a tool box which potentialities are illustrated by an example of the management of a “new chair” development problem.

[Students of today, physicians of tomorrow. Educational priorities for innovative teaching methods in medicine].

Science.gov (United States)

Guicciardi, Stefano; Riforgiato, Chiara; Leopardi, Eleonora

2015-02-01

In the past three years there has been increasing debate regarding the educational system of physicians in Italy, mainly due to the implementation of radical changes in the selection and admission criteria to medical courses. From the students' point of view, it is possible to identify different educational challenges to be faced in order to develop a more adequate learning system.First of all, it is necessary to elaborate an accurate planning of the physicians based on the needs of the Italian Healthcare System with a proportionate regulation of access to medical and specialty courses. Secondly, there is the strong need to update the traditional curricula based on a biological reductionist perspective with innovative and integrated courses that could teach new essential topics in a radically changed and globalized world, such as global health or medical ethics. Thirdly, it is crucial to introduce innovative teaching methods that could help students improve and evaluate their practical skills and participate actively in their own education, developing the attitudes and competences needed in their future profession.

Development of risk benefit structural design method for innovative reactor plants

International Nuclear Information System (INIS)

Yoshio Kamishima; Tai Asayama; Yukio Takahashi; Masanori Tashimo; Hideo Machida; Yomomi Otani; Yasuharu Chuman

2005-01-01

The development of innovative nuclear plants where the energy in the future is carried out in Japan. The design method based on a risk benefit of having maintained mitigation of a risk and the improvement in economy is called for, in order to realize the national innovative nuclear plants. Main key technologies of the risk benefit structural design method are crack propagation evaluation technology and structural reliability evaluation technology. This research aims at pulling up these two technologies on an engineering practical use level. In this paper, requirements from the design of typical innovative nuclear plants and research plan are shown.(authors)

Proceedings of the international conference on radiation biology and clinical applications: a molecular approach towards innovations in applied radiobiology and a workshop on strategies in radiation research

International Nuclear Information System (INIS)

2013-10-01

Innovations in radiotherapy approaches to cancer and radiation biology research is of growing interest in radiation researchers to conduct preclinical studies at their centers and translating the results as soon as possible to clinical radiotherapy practice. Recent papers have greatly enriched the current knowledge of radiation oncology, especially radiobiology and molecular oncology, and this has radically changed the oncology practice in radiation therapy in just a few years. The conference theme highlights the molecular and cellular responses within tissue and higher levels of mammalian biological organization. New experimental radiobiology research to underpin current and future regulatory decisions setting workplace exposure limits. To develop rapid, high-precision analytical methods that assess radiation exposure doses from clinical samples and thus aid in the triage and medical management of radiological casualties. Innovative approaches to improve the accuracy, dose range, ease of use, and speed of classical biodosimetry. Papers relevant to INIS are indexed separately

Methods of assessing functioning of organizational and economic mechanism during innovation process implementation

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Blinkov Maksim

2017-01-01

Full Text Available This paper proposes methods of assessing the efficiency of organizational and economic mechanism of an industrial enterprise when implementing innovation processes. These methods allow continuous monitoring at all stages of innovation process implementation, lead to reduction in costs of innovation activity and enable maximum use of the creative potential of enterprise personnel. The significance and attractiveness of this method is ensured by the fact that it can be applied by industrial companies in any market fields regardless of the lifecycle stage applicable to the studied goods, company and/or innovative process because the composition and the number of specific indicators can be adjusted by the work group both before the study and in the course of the company’s innovative activities (at any stage of their implementation. The multi-sided approach proposed for assessing the efficiency of organizational and economic mechanism of the industrial enterprise when implementing innovation processes ensures full and accurate assessment of the impact of certain factors on the final result.

Innovative methods of popularizing technical education

Science.gov (United States)

Shkitsa, L. Y.; Panchuk, V. G.; Kornuta, V. A.

2017-05-01

There have been analyzed reasons of the loss of technical education’s popularity. Also, the analysis of known educational and production methods, oriented at the innovative model of development of society, was performed. It is stated that the acquisition of 21st century’s skills as a result of competition of technical education are natural for the DIY ideology, which was realized in the institutions like Fab Lab. The new educational strategy, based on project-based learning, is proposed to be implemented as a special laboratory with equipment, which would be a center of innovative development for students at the Technical University. Moreover, the list of projects planned for implementation, that includes not only projects, specific to a particular university, but also projects, demanded by society as a whole, is specified. It is worth to implement trendy projects in the laboratory, such as toy-like, ecological projects; projects of the energy dependence decrease or the energy efficiency increase, modern digital or innovative projects etc. The student should gain knowledge, skills and, possibly, equipment that are available for immediate usage on the labor market or for the realization of his own projects or the community’s projects in everyday life after the realization of the particular project at the laboratory

The Water-Energy-Food Nexus: Advancing Innovative, Policy-Relevant Methods

Science.gov (United States)

Crootof, A.; Albrecht, T.; Scott, C. A.

2017-12-01

The water-energy-food (WEF) nexus is rapidly expanding in scholarly literature and policy settings as a novel way to address complex Anthropocene challenges. The nexus approach aims to identify tradeoffs and synergies of water, energy, and food systems, internalize social and environmental impacts, and guide development of cross-sectoral policies. However, a primary limitation of the nexus approach is the absence - or gaps and inconsistent use - of adequate methods to advance an innovative and policy-relevant nexus approach. This paper presents an analytical framework to identify robust nexus methods that align with nexus thinking and highlights innovative nexus methods at the frontier. The current state of nexus methods was assessed with a systematic review of 245 journal articles and book chapters. This review revealed (a) use of specific and reproducible methods for nexus assessment is uncommon - less than one-third of the reviewed studies present explicit methods; (b) nexus methods frequently fall short of capturing interactions among water, energy, and food - the very concept they purport to address; (c) assessments strongly favor quantitative approaches - 70% use primarily quantitative tools; (d) use of social science methods is limited (26%); and (e) many nexus methods are confined to disciplinary silos - only about one-quarter combine methods from diverse disciplines and less than one-fifth utilize both quantitative and qualitative approaches. Despite some pitfalls of current nexus methods, there are a host of studies that offer innovative approaches to help quantify nexus linkages and interactions among sectors, conceptualize dynamic feedbacks, and support mixed method approaches to better understand WEF systems. Applying our analytical framework to all 245 studies, we identify, and analyze herein, seventeen studies that implement innovative multi-method and cross-scalar tools to demonstrate promising advances toward improved nexus assessment. This paper

Structured methods for customer-oriented innovation research

DEFF Research Database (Denmark)

Scholderer, Joachim

customers might have told them if they had only properly been asked beforehand. In the following, a short introduction will be given to structured research methods that are relatively easy to use and can help product developers prioritise their efforts and assess the market potential of innovative concepts....

Methods and tools for innovation management procuring enterprises

OpenAIRE

A. V. Bogomolov

2013-01-01

The traditional methods of quality control of grain, dock-led feasibility, proposed and tested in practice near-mill elevator innovative methods of management organization, introduction of resource-saving technologies, different allow using «piezo electronic sensor» more quickly and accurately detect early damage of grain of wheat and ensure its further storage without loss of quality are described.

Innovative Public Procurement Methods: Examples Of Selected Country And Lessons For Turkey

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Elif Ayşe ŞAHİN İPEK

2016-12-01

Full Text Available Innovative public procurement considered as demand-side policies aimed at economic competitiveness, growth and development through the development of private sector innovation supply. In this study it is examined the methods of innovative procurement policy and country examples. It is exerted obstacles and solutions from the results of this examination.

Mathematical methods in biology and neurobiology

CERN Document Server

Jost, Jürgen

2014-01-01

Mathematical models can be used to meet many of the challenges and opportunities offered by modern biology. The description of biological phenomena requires a range of mathematical theories. This is the case particularly for the emerging field of systems biology. Mathematical Methods in Biology and Neurobiology introduces and develops these mathematical structures and methods in a systematic manner. It studies:   • discrete structures and graph theory • stochastic processes • dynamical systems and partial differential equations • optimization and the calculus of variations.   The biological applications range from molecular to evolutionary and ecological levels, for example:   • cellular reaction kinetics and gene regulation • biological pattern formation and chemotaxis • the biophysics and dynamics of neurons • the coding of information in neuronal systems • phylogenetic tree reconstruction • branching processes and population genetics • optimal resource allocation • sexual recombi...

Innovative Methods in Strategic Planning of Foreign Economic Activity of Enterprises

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Valentyna Yakubiv

2017-12-01

Full Text Available Changes in the external conditions of business in Ukraine, European integration vector of the country development, and possibilities of import/export operations facilitate foreign trade. Modern methods of strategic management and strategic diagnostics should be developed in line with international requirements and needs of managers in Ukraine and partners abroad. Therefore substantiation of innovation trends for enterprise development strategies on the international arena as a constituent of stable economy is important and necessary. The purpose of this article is to define innovative approaches to planning, development and implementation of strategies and to develop a comprehensive diagnosis of the strategic potential of foreign economic activity. During the research, the following methods: logical abstraction, modeling, PEST-analysis, systems analysis, graphic. The main results of the study are: 1 disclosure of the features of the construction of strategic management in international business; 2 analysis of European and American practices of strategic management of foreign economic activity of enterprises; 3 study of algorithmic scheme of strategic management in the Ukraine; 4 justification of methods of three-level system of strategic analysis using matrix methods of assessment; 5 the classification of the main methods of matrix analysis within groups: macro, meso, macro level; 6 a comprehensive diagnosis of the strategic potential of foreign economic activity of enterprises in Ukraine. The study proved the main areas of innovation and strategic principles of international management and comprehensive methodology for strategic planning matrix based on innovative methods.

Methods and tools for innovation management procuring enterprises

Directory of Open Access Journals (Sweden)

A. V. Bogomolov

2013-01-01

Full Text Available The traditional methods of quality control of grain, dock-led feasibility, proposed and tested in practice near-mill elevator innovative methods of management organization, introduction of resource-saving technologies, different allow using «piezo electronic sensor» more quickly and accurately detect early damage of grain of wheat and ensure its further storage without loss of quality are described.

MINOR INNOVATIVE ENTERPRISES AND METHODS OF THEIR FINANCING IN RUSSIA

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A. G. Komissarov

2011-01-01

Full Text Available Minor enterprises do not have resources sufficient for investment. Present experience of venture financing and attraction of funds from finance markets is poor in Russia. Main minor entrepreneurship financing sources are state allocations in the form of subsidies, subventionsand donations. This support promotes economics diversification and increases jobs. The state becomes client of innovations and provides for business environment favorable for minor entrepreneurship and for subsequent diffusion of innovations. One of most efficient innovationactivity stimulation methods (applied to minor enterprises as well is provision for tax privileges, favorable state bank credits and preferences to innovation activity supporting commercial banks.

Football refereeing: Identifying innovative methods

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Reza MohammadKazemi

2014-08-01

Full Text Available The aim of the present study is to identify the potentials innovation in football industry. Data were collected from 10 national and international referees, assistant referees and referees’ supervisors in Iran. In this study, technological innovations are identified that assist better refereeing performances. The analysis revealed a significant relationship between using new technologies and referees ‘performance. The results indicate that elite referees, assistant referees and supervisors agreed to use new technological innovations during the game. According to their comments, this kind of technology causes the referees’ performance development.

Determination of Innovation Capability of Organizations: Qualitative Meta Synthesis and Delphi Method

DEFF Research Database (Denmark)

Momeni, Mostafa; Nielsen, Susanne Balslev; Kafash, Mahdi Haghighi

2015-01-01

. The innovation capability is associated with other organizational capabilities. So, many organizations have focused on the need to identify innovation capabilities and resources or strengths in relation to external opportunities and threats according to inside-out view because innovation capability has...... capability in the organizations and this paper includes an expert based validation in three rounds of the Delphi method. This research proposed a direct relationship between Innovation Capability and three main capabilities that is called Structural Capability, Personnel Capability and Operational Capability...

Reassembling the Information Technology Innovation Process: An Actor Network Theory Method for Managing the Initiation, Production, and Diffusion of Innovations

Science.gov (United States)

Zendejas, Gerardo; Chiasson, Mike

This paper will propose and explore a method to enhance focal actors' abilities to enroll and control the many social and technical components interacting during the initiation, production, and diffusion of innovations. The reassembling and stabilizing of such components is the challenging goal of the focal actors involved in these processes. To address this possibility, a healthcare project involving the initiation, production, and diffusion of an IT-based innovation will be influenced by the researcher, using concepts from actor network theory (ANT), within an action research methodology (ARM). The experiences using this method, and the nature of enrolment and translation during its use, will highlight if and how ANT can provide a problem-solving method to help assemble the social and technical actants involved in the diffusion of an innovation. Finally, the paper will discuss the challenges and benefits of implementing such methods to attain widespread diffusion.

Supplier selection in manufacturing innovation chain-oriented public procurement based on improved PSO method

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Xin Xu

2014-01-01

Full Text Available Purpose: At the dynamic innovation market, it is very difficult for an enterprise to accomplish innovation individually; technology innovation is shifting towards collaborative R&D chain mode. Thus, supplier selection based on individually innovation efficiency of enterprise is inapplicable to construct collaborative R&D innovation chain. This study is seeking to address how to select R&D innovation chain supplier in manufacturing industry. Design/methodology/approach: Firstly, Delphi method and AHP method are applied to establish an index system evaluating the suppliers of innovation chain, and then each index is weighted by experts with AHP method. Thirdly, optimized PSO algorithm is put forwarded based on the optimal efficiency of innovation chain to discriminate ideal suppliers meeting realistic conditions. Fourthly, innovation chain construction at generator manufacturing industry was taken as empirical case study to testify the improved PSO model. Findings: The innovation chain is comprised up by several enterprises, innovation performance of a single enterprise is not always positively correlated to that of one innovation chain, and the proposed model is capable to find out the best combination to construct an innovation chain. Research limitations/implications: The relations between these constructs with other variables of interest to the academicals fields were analyzed by a precise and credible data with a clear and concise description of the supply chain integration measurement scales. Practical implications: providing scales that are valid as a diagnostic tool for best practices, as well as providing a benchmark with which to compare the score for each individual plant against a chain of industrial innovation from machinery. Originality/value: Innovation chain integration is an important factor in explaining the innovation performance of companies. The vast range of results obtained is due to the fact that there is no exactness to

Utilizing the Lead User Method for Promoting Innovation in E-Recuiting

NARCIS (Netherlands)

Furtmueller-Ettinger, Elfriede; Wilderom, Celeste P.M.; van Dick, Rolf; Bondarouk, Tatiana; Ruel, Hubertus Johannes Maria; Guiderdoni-Jourdain, Karine; Oiry, Ewan

2009-01-01

In order to maintain their customer base, many e-recruiting firms are in need of developing innovations. The Lead User (LU) Method has been heralded in the new product innovation literature but not yet applied often in e-service settings. Based on an e-recruiting portal, the authors compare new

Using Co-innovation to Stimulate Innovation in the New Zealand Agricultural Sector

NARCIS (Netherlands)

Botha, N.; Klerkx, L.W.A.; Small, B.; Turner, J.A.

2014-01-01

A recently implemented research and development program; Co-learning and Coinnovation to Achieve Impact in New Zealand’s Biological Industries (Primary Innovation for short) aims to stimulate innovation in the New Zealand agricultural sector, which is an important contributor to the New Zealand

Innovative research methods for studying treatments for rare diseases: methodological review.

Science.gov (United States)

Gagne, Joshua J; Thompson, Lauren; O'Keefe, Kelly; Kesselheim, Aaron S

2014-11-24

To examine methods for generating evidence on health outcomes in patients with rare diseases. Methodological review of existing literature. PubMed, Embase, and Academic Search Premier searched for articles describing innovative approaches to randomized trial design and analysis methods and methods for conducting observational research in patients with rare diseases. We assessed information related to the proposed methods, the specific rare disease being studied, and outcomes from the application of the methods. We summarize methods with respect to their advantages in studying health outcomes in rare diseases and provide examples of their application. We identified 46 articles that proposed or described methods for studying patient health outcomes in rare diseases. Articles covered a wide range of rare diseases and most (72%) were published in 2008 or later. We identified 16 research strategies for studying rare disease. Innovative clinical trial methods minimize sample size requirements (n=4) and maximize the proportion of patients who receive active treatment (n=2), strategies crucial to studying small populations of patients with limited treatment choices. No studies describing unique methods for conducting observational studies in patients with rare diseases were identified. Though numerous studies apply unique clinical trial designs and considerations to assess patient health outcomes in rare diseases, less attention has been paid to innovative methods for studying rare diseases using observational data. © Gagne et al 2014.

Using of innovative educational and traning methods in the professional training of social workers

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Lidiia Tymkiv

2017-03-01

Full Text Available The article deals with the use of innovative methods of training professional values ofsocial workers. It has been shown, that the use of innovative technologies in the educationalprocess will enhance the mental and social activities of prospective specialists in the socialsphere and prepare them for independent decision-making consistent with the acquired values.Key words : innovative methods of training, role games, game situation of professionaldirection.

Bioelectrochemical removal of carbon dioxide (CO2): an innovative method for biogas upgrading.

Science.gov (United States)

Xu, Heng; Wang, Kaijun; Holmes, Dawn E

2014-12-01

Innovative methods for biogas upgrading based on biological/in-situ concepts have started to arouse considerable interest. Bioelectrochemical removal of CO2 for biogas upgrading was proposed here and demonstrated in both batch and continuous experiments. The in-situ biogas upgrading system seemed to perform better than the ex-situ one, but CO2 content was kept below 10% in both systems. The in-situ system's performance was further enhanced under continuous operation. Hydrogenotrophic methanogenesis and alkali production with CO2 absorption could be major contributors to biogas upgrading. Molecular studies showed that all the biocathodes associated with biogas upgrading were dominated by sequences most similar to the same hydrogenotrophic methanogen species, Methanobacterium petrolearium (97-99% sequence identity). Conclusively, bioelectrochemical removal of CO2 showed great potential for biogas upgrading. Copyright © 2014 Elsevier Ltd. All rights reserved.

Regional collaborations and indigenous innovation capabilities in China: A multivariate method for the analysis of regional innovation systems

OpenAIRE

Zhao, S.L.; Cacciolatti, L.; Lee, Soo Hee; Song, W.

2014-01-01

In this study we analyse the emerging patterns of regional collaboration for innovation projects in China, using official government statistics of 30 Chinese regions. We propose the use of Ordinal Multidimensional Scaling and Cluster analysis as a robust method to study regional innovation systems. Our results show that regional collaborations amongst organisations can be categorised by means of eight dimensions: public versus private organisational mindset; public versus private resources; i...

PHIRE (Public Health Innovation and Research in Europe): methods, structures and evaluation.

Science.gov (United States)

Barnhoorn, Floris; McCarthy, Mark; Devillé, Walter; Alexanderson, Kristina; Voss, Margaretha; Conceição, Claudia

2013-11-01

Public Health Innovation and Research in Europe (PHIRE), building on previous European collaborative projects, was developed to assess national uptake and impacts of European public health innovations, to describe national public health research programmes, strategies and structures and to develop participation of researchers through the organizational structures of the European Public Health Association (EUPHA). This article describes the methods used. PHIRE was led by EUPHA with seven partner organisations over 30 months. It was conceived to engage the organisation of EUPHA--working through its thematic Sections, and through its national public health associations--and assess innovation and research across 30 European countries. Public health research was defined broadly as health research at population and organisational level. There were seven Work Packages (three covering coordination and four for technical aspects) led by partners and coordinated through management meetings. Seven EUPHA Sections identified eight innovations within the projects funded by the Public Health Programme of the European Commission Directorate for Health and Consumers. Country informants, identified through EUPHA thematic Sections, reported on national uptake of the innovations in eight public health projects supported by the European Union Public Health Programme. Four PHIRE partners, each taking a regional sector of Europe, worked with the public health associations and other informants to describe public health research programmes, calls and systems. A classification was created for the national public health research programmes and calls in 2010. The internal and external evaluations were supportive. PHIRE described public health innovations and research across Europe through national experts. More work is needed to conceptualize and define public health 'innovations' and to develop theories and methods for the assessment of their uptake and impacts at country and cross

An novel frequent probability pattern mining algorithm based on circuit simulation method in uncertain biological networks

Science.gov (United States)

2014-01-01

Background Motif mining has always been a hot research topic in bioinformatics. Most of current research on biological networks focuses on exact motif mining. However, due to the inevitable experimental error and noisy data, biological network data represented as the probability model could better reflect the authenticity and biological significance, therefore, it is more biological meaningful to discover probability motif in uncertain biological networks. One of the key steps in probability motif mining is frequent pattern discovery which is usually based on the possible world model having a relatively high computational complexity. Methods In this paper, we present a novel method for detecting frequent probability patterns based on circuit simulation in the uncertain biological networks. First, the partition based efficient search is applied to the non-tree like subgraph mining where the probability of occurrence in random networks is small. Then, an algorithm of probability isomorphic based on circuit simulation is proposed. The probability isomorphic combines the analysis of circuit topology structure with related physical properties of voltage in order to evaluate the probability isomorphism between probability subgraphs. The circuit simulation based probability isomorphic can avoid using traditional possible world model. Finally, based on the algorithm of probability subgraph isomorphism, two-step hierarchical clustering method is used to cluster subgraphs, and discover frequent probability patterns from the clusters. Results The experiment results on data sets of the Protein-Protein Interaction (PPI) networks and the transcriptional regulatory networks of E. coli and S. cerevisiae show that the proposed method can efficiently discover the frequent probability subgraphs. The discovered subgraphs in our study contain all probability motifs reported in the experiments published in other related papers. Conclusions The algorithm of probability graph isomorphism

Use of Biological Methods in Criminology

OpenAIRE

Müllerová, Nikola

2014-01-01

Criminology is a science dealing with the protection of citizens and state from infringement. Criminology uses mostly biological or genetic methods for crime detection. Forensic traces which are collected by forensic experts on the scene are the key items of those methods. Forensic genetics is among the most important forensic subdisciplines. Forensic genetics uses DNA analysis for identification. The main aims of this study are description and importance of biological, anthropological and ge...

Strengthening regional innovation through network-based innovation brokering

OpenAIRE

Svare, Helge; Gausdal, Anne Haugen

2015-01-01

The primary objective of this paper is to demonstrate how regional innovation system theory may be translated into manageable micro-level methods with the potential for strengthening the productive dynamics of a regional innovation system. The paper meets this objective by presenting network-based innovation brokering (NBIB), a practical method designed using insights from regional innovation system theory and trust theory. Five cases from two Norwegian regional innovation networks show that ...

User Innovation Management

DEFF Research Database (Denmark)

Kanstrup, Anne Marie; Bertelsen, Pernille

User Innovation Management (UIM) is a method for fo-opereation with users in innovation projects. The UIM method emphasizes the practice of a participatorty attitude.......User Innovation Management (UIM) is a method for fo-opereation with users in innovation projects. The UIM method emphasizes the practice of a participatorty attitude....

DEVELOPMENT OF ASSESSMENT METHODS OF EFFECTIVENESS OF INNOVATIVE STAFF ACTIVITY MOTIVATIONAL MECHANISM

Directory of Open Access Journals (Sweden)

Viktoriia Honchar

2016-11-01

Full Text Available The aim of the science work is to develop methods to assess the innovative activity of the personnel that will provide motivation for employees to be active in the direction of research and introduction of internal reserves for its improvement. Methods. In the study were used: system method and methods of logical analysis – to justify theoretical and practical recommendations on the development of conceptual bases of the formation of the motivational mechanism of personnel management, economic-mathematical modelling and forecasting methods – to assess the influence of motivation factors on the level of labour activity of the personnel. Results. In the work the notion “motivation”, considering the innovative changes of the modern economy, is clarified. In order to foster innovative activity in the enterprise it is proposed to improve organizational structure by controlling the center of innovation activity management, which includes economic, technical and social division. Proposed an establishment of the project teams under the terms of accounting costs, which contributes to more active workers’ involvement in the formation of innovative development plans. The main points that determine their effectiveness are: growth of volumes of output, diminution of expenses of materials and energy resources, timeliness and relevance to the product market, improvement of the quality of work performed. A profit, derived by project teams, is recommended to distribute on: increment of the payroll, innovative development, stimulation and motivation fund. The research of the activity of the enterprises showed that one of the effective methods to stimulate staff is a motivational system based on the use of KPI. Bonuses for the implemented project, which are adjusted to the output of the basic stage, or KPI project as a whole, fixed bonuses as a percentage of the profits, and bonuses in stages of the project are the forms of motivation of project teams

Room for improvement? Leadership, innovation culture and uptake of quality improvement methods in general practice.

Science.gov (United States)

Apekey, Tanefa A; McSorley, Gerry; Tilling, Michelle; Siriwardena, A Niroshan

2011-04-01

Leadership and innovation are currently seen as essential elements for the development and maintenance of high-quality care. Little is known about the relationship between leadership and culture of innovation and the extent to which quality improvement methods are used in general practice. This study aimed to assess the relationship between leadership behaviour, culture of innovation and adoption of quality improvement methods in general practice. Self-administered postal questionnaires were sent to general practitioner quality improvement leads in one county in the UK between June and December 2007. The questionnaire consisted of background information, a 12-item scale to assess leadership behaviour, a seven-dimension self-rating scale for culture of innovation and questions on current use of quality improvement tools and techniques. Sixty-three completed questionnaires (62%) were returned. Leadership behaviours were not commonly reported. Most practices reported a positive culture of innovation, featuring relationship most strongly, followed by targets and information but rated lower on other dimensions of rewards, risk and resources. There was a significant positive correlation between leadership behaviour and the culture of innovation (r = 0.57; P improvement methods were not adopted by most participating practices. Leadership behaviours were infrequently reported and this was associated with a limited culture of innovation in participating general practices. There was little use of quality improvement methods beyond clinical and significant event audit. Practices need support to enhance leadership skills, encourage innovation and develop quality improvement skills if improvements in health care are to accelerate. © 2010 Blackwell Publishing Ltd.

APPLICATION OF FORMS AND METHODS OF COMMERCIALIZATION OF INNOVATIONS THROUGH THE INTERACTION OF UNIVERSITIES AND ENTERPRISES

Directory of Open Access Journals (Sweden)

Svetlana E. Sitnikova

2018-03-01

Full Text Available In the conditions of formation of economy based on knowledge, a key condition for successful development is the effective integration of science, education and business. Currently, the commercialization of innovation becomes a necessary factor for sustainable development of universities, one of their main tools to increase its competitiveness in the market of educational services and products. The efficiency of the process of innovation commercialization is conditioned by the rational choice of forms and methods of implementing this process. The interaction of universities and enterprises in the innovative clusters provides benefits such as effective dissemination of information about the creation of innovations, the relevant areas of research, the granting of preferences to cluster participants. The creation of technoparks suggests the presence of a specially allocated site, which houses many new businesses, so that existing institutions can only be partners of the technopark. From the point of view of commercialization of University innovation, the cluster seems to be a more attractive method compared with the creation of technology parks, but its application is necessary to adjust the approach to conducting the state policy in the field of innovation management. The interaction of universities and enterprises via an intermediary – the chamber of commerce and industry – can be described as an obstacle to the commercialization of university innovations. On the contrary, technological innovation center protects the interests of universities, rather than enterprises, as it is created to facilitate the commercialization of university innovation. Direct interaction of universities and enterprises becomes possible with the help of methods of a single transaction, a regular cooperation and a contract for the supply of innovation. The choice of methods of commercialization of innovations should be made on the basis of existing university

From individual innovation to global impact: the Global Cooperation on Assistive Technology (GATE) innovation snapshot as a method for sharing and scaling.

Science.gov (United States)

Layton, Natasha; Murphy, Caitlin; Bell, Diane

2018-05-09

Assistive technology (AT) is an essential facilitator of independence and participation, both for people living with the effects of disability and/or non-communicable disease, as well as people aging with resultant functional decline. The World Health Organization (WHO) recognizes the substantial gap between the need for and provision of AT and is leading change through the Global Cooperation on Assistive Technology (GATE) initiative. Showcasing innovations gathered from 92 global researchers, innovators, users and educators of AT through the WHO GREAT Summit, this article provides an analysis of ideas and actions on a range of dimensions in order to provide a global overview of AT innovation. The accessible method used to capture and showcase this data is presented and critiqued, concluding that "innovation snapshots" are a rapid and concise strategy to capture and showcase AT innovation and to foster global collaboration. Implications for Rehabilitation Focal tools such as ePosters with uniform data requirements enable the rapid sharing of information. A diversity of innovative practices are occurring globally in the areas of AT Products, Policy, Provision, People and Personnel. The method offered for Innovation Snapshots had substantial uptake and is a feasible means to capture data across a range of stakeholders. Meeting accessibility criteria is an emerging competency in the AT community. Substantial areas of common interest exist across regions and globally in the AT community, demonstrating the effectiveness of information sharing platforms such as GATE and supporting the idea of regional forums and networks.

Mathematical methods in systems biology.

Science.gov (United States)

Kashdan, Eugene; Duncan, Dominique; Parnell, Andrew; Schattler, Heinz

2016-12-01

The editors of this Special Issue of Mathematical Biosciences and Engineering were the organizers for the Third International Workshop "Mathematical Methods in System Biology" that took place on June 15-18, 2015 at the University College Dublin in Ireland. As stated in the workshop goals, we managed to attract a good mix of mathematicians and statisticians working on biological and medical applications with biologists and clinicians interested in presenting their challenging problems and looking to find mathematical and statistical tools for their solutions.

Sources of innovation in agricultural technology

Energy Technology Data Exchange (ETDEWEB)

Biggs, S D; Clay, E J

1981-04-01

This paper focuses attention on environmental and biological characteristics of agriculture which shape the process of technical innovation. The interaction of natural selection and human purposive selection and experimentation is shown to result in a continuous process of innovation placing farmers in the informal R and D systems as well as scientists in formal R and D systems in an innovative treadmill. The importance and limitations of informal R and D are reviewed. A discussion of the characteristics and potential of formal R and D systems leads to the identification of some major problems of policy inherent in, and specific to, the organization and management of agricultural research resources. These include: genetic vulnerability, choices between environmentally specific or widely adapted technologies, the location of research activity, the linkages between agricultural producers and scientists, and methods for maintaining and strengthening informal R and D systems. 58 references, 2 figures.

On managing innovation by design : Towards SMART methods

NARCIS (Netherlands)

Vermaas, P.E.

2012-01-01

In this paper innovation by design is characterised schematically and methodological with the aim of analysing how projects of innovation by design can be managed. First, I approach innovation by design from an engineering perspective, and show that the incorporation of innovation into design

RESULTS OF ANALYSIS OF BENCHMARKING METHODS OF INNOVATION SYSTEMS ASSESSMENT IN ACCORDANCE WITH AIMS OF SUSTAINABLE DEVELOPMENT OF SOCIETY

Directory of Open Access Journals (Sweden)

A. Vylegzhanina

2016-01-01

Full Text Available In this work, we introduce results of comparative analysis of international ratings indexes of innovation systems for their compliance with purposes of sustainable development. Purpose of this research is defining requirements to benchmarking methods of assessing national or regional innovation systems and compare them basing on assumption, that innovation system is aligned with sustainable development concept. Analysis of goal sets and concepts, which underlie observed international composite innovation indexes, comparison of their metrics and calculation techniques, allowed us to reveal opportunities and limitations of using these methods in frames of sustainable development concept. We formulated targets of innovation development on the base of innovation priorities of sustainable socio-economic development. Using comparative analysis of indexes with these targets, we revealed two methods of assessing innovation systems, maximally connected with goals of sustainable development. Nevertheless, today no any benchmarking method, which meets need of innovation systems assessing in compliance with sustainable development concept to a sufficient extent. We suggested practical directions of developing methods, assessing innovation systems in compliance with goals of societal sustainable development.

Biological Methods and Manual Development

Science.gov (United States)

EPA scientists conduct research to develop and evaluate analytical methods for the identification, enumeration, evaluation of aquatic organisms exposed to environmental stressors and to correlate exposures with effects on chemical and biological indicators

The Innovative Bike Conceptual Design by Using Modified Functional Element Design Method

Directory of Open Access Journals (Sweden)

Nien-Te Liu

2016-11-01

Full Text Available The purpose of the study is to propose a new design process by modifying functional element design approach which can commence a large amount of innovative concepts within a short period of time. Firstly, the original creative functional elements design method is analyzed and the drawbacks are discussed. Then, the modified is proposed and is divided into 6 steps. The creative functional element representations, generalization, specialization, and particularization are used in this method. Every step is described clearly, and users could design by following the process easily. In this paper, a clear and accurate design process is proposed based on the creative functional element design method. By following this method, a lot of innovative bicycles will be created quickly.

HOW DO FIRMS SOURCE EXTERNAL KNOWLEDGE FOR INNOVATION? ANALYSING EFFECTS OF DIFFERENT KNOWLEDGE SOURCING METHODS

OpenAIRE

KI H. KANG; JINA KANG

2009-01-01

In the era of "open innovation", external knowledge is a very important source for technology innovation. In this paper, we investigate the relationship between external knowledge and performance of technology innovation. The effect of external knowledge on the performance of technology innovation can vary with different external knowledge sourcing methods. We identify three ways of external knowledge sourcing: information transfer from informal network, R&D collaboration and technology acqui...

Governing Methods: Policy Innovation Labs, Design and Data Science in the Digital Governance of Education

Science.gov (United States)

Williamson, Ben

2015-01-01

Policy innovation labs are emerging knowledge actors and technical experts in the governing of education. The article offers a historical and conceptual account of the organisational form of the policy innovation lab. Policy innovation labs are characterised by specific methods and techniques of design, data science, and digitisation in public…

Innovative teaching methods for capacity building in knowledge translation

Directory of Open Access Journals (Sweden)

Al-Ansary Lubna A

2011-10-01

Full Text Available Abstract Background In some current healthcare settings, there is a noticeable absence of national institutions committed to the synthesis and use of evidence in healthcare decision- and policy-making. This absence creates a need to broaden the responsibilities of healthcare providers to include knowledge brokering and advocacy in order to optimize knowledge translation to other stakeholders, especially policy-makers. However, this process requires practitioners and researchers to acquire certain types of knowledge and skills. This article introduces two innovative methods for capacity building in knowledge translation (KT. Methods During a workshop aimed at preparing 21 trainers in evidence-based medicine, two innovative methods were used: (1 debate and (2 a knowledge translation project (KTP. The main objective of the debates approach was to strengthen participants' critical thinking abilities by requiring them to search for and appraise evidence and defend their arguments. The KTP was used to introduce participants to the essential steps of knowledge translation and to suggest an extended role for healthcare practitioners, i.e., using evidence to manage not only individual patients but also to a community of patients. Participants' performances were assessed according to a pre-designed scheme. At the end of the workshop, participants' opinions and experiences with the innovative teaching methods were evaluated based on their answers to a questionnaire and the results of small-group discussions. Results The participants performed well in both the debate and KTP methods. During post-workshop group discussions, they indicated that the debate approach had added a new dimension to their evidence-based medicine skills by adding purpose and motivation. However, they felt that their performances would have been better if they had been offered practical demonstrations of how to conduct the debate. The participants indicated that the KTP enhanced their

Paradigms for biologically inspired design

DEFF Research Database (Denmark)

Lenau, T. A.; Metzea, A.-L.; Hesselberg, T.

2018-01-01

engineering, medical engineering, nanotechnology, photonics,environmental protection and agriculture. However, a major obstacle for the wider use of biologically inspired design isthe knowledge barrier that exist between the application engineers that have insight into how to design suitable productsand......Biologically inspired design is attracting increasing interest since it offers access to a huge biological repository of wellproven design principles that can be used for developing new and innovative products. Biological phenomena can inspireproduct innovation in as diverse areas as mechanical...... the biologists with detailed knowledge and experience in understanding how biological organisms function in theirenvironment. The biologically inspired design process can therefore be approached using different design paradigmsdepending on the dominant opportunities, challenges and knowledge characteristics...

Sequential method for the assessment of innovations in computer assisted industrial processes

International Nuclear Information System (INIS)

Suarez Antola R.

1995-01-01

A sequential method for the assessment of innovations in industrial processes is proposed, using suitable combinations of mathematical modelling and numerical simulation of dynamics. Some advantages and limitations of the proposed method are discussed. tabs

Open Innovation Drug Discovery (OIDD): a potential path to novel therapeutic chemical space.

Science.gov (United States)

Alvim-Gaston, Maria; Grese, Timothy; Mahoui, Abdelaziz; Palkowitz, Alan D; Pineiro-Nunez, Marta; Watson, Ian

2014-01-01

The continued development of computational and synthetic methods has enabled the enumeration or preparation of a nearly endless universe of chemical structures. Nevertheless, the ability of this chemical universe to deliver small molecules that can both modulate biological targets and have drug-like physicochemical properties continues to be a topic of interest to the pharmaceutical industry and academic researchers alike. The chemical space described by public, commercial, in-house and virtual compound collections has been interrogated by multiple approaches including biochemical, cellular and virtual screening, diversity analysis, and in-silico profiling. However, current drugs and known chemical probes derived from these efforts are contained within a remarkably small volume of the predicted chemical space. Access to more diverse classes of chemical scaffolds that maintain the properties relevant for drug discovery is certainly needed to meet the increasing demands for pharmaceutical innovation. The Lilly Open Innovation Drug Discovery platform (OIDD) was designed to tackle barriers to innovation through the identification of novel molecules active in relevant disease biology models. In this article we will discuss several computational approaches towards describing novel, biologically active, drug-like chemical space and illustrate how the OIDD program may facilitate access to previously untapped molecules that may aid in the search for innovative pharmaceuticals.

Method to detect biological particles

International Nuclear Information System (INIS)

Giaever, I.

1976-01-01

A medical-diagnostic method to detect immunological as well as other specific reactions is described. According to the invention, first reactive particles (e.g. antibodies) are adsorbed on the surface of a solid, non-reactive substrate. The coated substrate is subjected to a solution which one assumes to contain the second biological particles (e.g. antigens) which are specific to the first and form complexes with these. A preferential radioactive labelling (e.g. with iodine 125) of the second biological particle is then directly or indirectly carried out. Clearage follows labelling in order to separate the second biological particles from the first ones. A specific splitting agent can selectively break the bond of both types of particle. The splitting agent solution is finally separated off and its content is investigated for the presence of labelling. (VJ) [de

Transforming Elementary Science Teacher Education by Bridging Formal and Informal Science Education in an Innovative Science Methods Course

Science.gov (United States)

Riedinger, Kelly; Marbach-Ad, Gili; McGinnis, J. Randy; Hestness, Emily; Pease, Rebecca

2011-01-01

We investigated curricular and pedagogical innovations in an undergraduate science methods course for elementary education majors at the University of Maryland. The goals of the innovative elementary science methods course included: improving students' attitudes toward and views of science and science teaching, to model innovative science teaching…

Bioconductor: open software development for computational biology and bioinformatics

DEFF Research Database (Denmark)

Gentleman, R.C.; Carey, V.J.; Bates, D.M.

2004-01-01

The Bioconductor project is an initiative for the collaborative creation of extensible software for computational biology and bioinformatics. The goals of the project include: fostering collaborative development and widespread use of innovative software, reducing barriers to entry into interdisci......The Bioconductor project is an initiative for the collaborative creation of extensible software for computational biology and bioinformatics. The goals of the project include: fostering collaborative development and widespread use of innovative software, reducing barriers to entry...... into interdisciplinary scientific research, and promoting the achievement of remote reproducibility of research results. We describe details of our aims and methods, identify current challenges, compare Bioconductor to other open bioinformatics projects, and provide working examples....

EFFECT OF CORPORATE INNOVATION ABILITY ON THE CHOICE BETWEEN PRODUCT INNOVATION AND PROCESS INNOVATION

OpenAIRE

Zeng Wu; Tian Zhilong

2010-01-01

With the method of duopoly game theory, the effect of firms’ innovation ability on the choice between product and process innovation is studied. The concept of cost coefficient of product innovation is introduced, and the criterion equation for the innovation type is derived. The following conclusions are made: the more the product innovation ability, the more the possibility for the firms to carry out the product innovation in both the Bertrand and the Cournot competitions. Wi...

Micro-separation toward systems biology.

Science.gov (United States)

Liu, Bi-Feng; Xu, Bo; Zhang, Guisen; Du, Wei; Luo, Qingming

2006-02-17

Current biology is experiencing transformation in logic or philosophy that forces us to reevaluate the concept of cell, tissue or entire organism as a collection of individual components. Systems biology that aims at understanding biological system at the systems level is an emerging research area, which involves interdisciplinary collaborations of life sciences, computational and mathematical sciences, systems engineering, and analytical technology, etc. For analytical chemistry, developing innovative methods to meet the requirement of systems biology represents new challenges as also opportunities and responsibility. In this review, systems biology-oriented micro-separation technologies are introduced for comprehensive profiling of genome, proteome and metabolome, characterization of biomolecules interaction and single cell analysis such as capillary electrophoresis, ultra-thin layer gel electrophoresis, micro-column liquid chromatography, and their multidimensional combinations, parallel integrations, microfabricated formats, and nano technology involvement. Future challenges and directions are also suggested.

Open innovations, innovation communities and firm's innovative activities

Directory of Open Access Journals (Sweden)

Getejanc Vesna

2016-01-01

Full Text Available The open innovation paradigm emphasizes the fact that firms can improve their performance by opening their business models and reduce their R&D costs by effective incorporation of external knowledge. In other words, companies are able to capture value through knowledge that exists outside the boundaries of their organization. The shift from closed to open model of innovation has imposed the necessity to adopt more open approach to innovation within traditional academic view of business strategy. The adoption of this innovative approach is emphasized even more, by the necessity for stronger connection and cooperation among the participants of the innovation process. Free will and collaboration are the main characteristics of open source software, which is recognized in literature as the role model of open innovation and is a rapidly growing method of technology development. Furthermore, innovative communities represent a great opportunity for improvement of the companies' innovation activities, since they have become an important source for identifying the needs and problems of the users. Their development has been fostered by information technologies and recent social changes in user behavior. Recognizing and better understanding the motivation of the members of the innovation communities that guide them to participate in the process of idea generation, can have significant influence on their incorporation within the innovation process. Equally important is to define the incentives that are suited for stimulating and fostering innovative user activities. Taking this topic in consideration, the purpose of this article is to address the following questions: In what way does the collaboration in open source software projects have positive effect on companies' innovation performance? What are the innovation communities and how can companies establish successful interaction with them? Why does the interaction with innovation communities lead to

Methods for innovation : the varying role of industrial research in DSM's nitrogen fertilizer business, 1925-1970

NARCIS (Netherlands)

Rooij, van J.W.

2007-01-01

In this article the varying methods firms use to innovate are central in an attempt to balance our understanding of innovation processes. Often, research-driven innovation attracts the most attention, obscuring the contributions of other company functions and of external technology. In this article,

Design theory methods and organization for innovation

CERN Document Server

Le Masson, Pascal; Hatchuel, Armand

2017-01-01

This textbook presents the core of recent advances in design theory and its implications for design methods and design organization. Providing a unified perspective on different design methods and approaches, from the most classic (systematic design) to the most advanced (C-K theory), it offers a unique and integrated presentation of traditional and contemporary theories in the field. Examining the principles of each theory, this guide utilizes numerous real life industrial applications, with clear links to engineering design, industrial design, management, economics, psychology and creativity. Containing a section of exams with detailed answers, it is useful for courses in design theory, engineering design and advanced innovation management. "Students and professors, practitioners and researchers in diverse disciplines, interested in design, will find in this book a rich and vital source for studying fundamental design methods and tools as well as the most advanced design theories that work in practice". Pro...

Innovative teaching methods for capacity building in knowledge translation.

Science.gov (United States)

Wahabi, Hayfaa A; Al-Ansary, Lubna A

2011-10-14

In some current healthcare settings, there is a noticeable absence of national institutions committed to the synthesis and use of evidence in healthcare decision- and policy-making. This absence creates a need to broaden the responsibilities of healthcare providers to include knowledge brokering and advocacy in order to optimize knowledge translation to other stakeholders, especially policy-makers. However, this process requires practitioners and researchers to acquire certain types of knowledge and skills. This article introduces two innovative methods for capacity building in knowledge translation (KT). During a workshop aimed at preparing 21 trainers in evidence-based medicine, two innovative methods were used: (1) debate and (2) a knowledge translation project (KTP). The main objective of the debates approach was to strengthen participants' critical thinking abilities by requiring them to search for and appraise evidence and defend their arguments. The KTP was used to introduce participants to the essential steps of knowledge translation and to suggest an extended role for healthcare practitioners, i.e., using evidence to manage not only individual patients but also to a community of patients. Participants' performances were assessed according to a pre-designed scheme. At the end of the workshop, participants' opinions and experiences with the innovative teaching methods were evaluated based on their answers to a questionnaire and the results of small-group discussions. The participants performed well in both the debate and KTP methods. During post-workshop group discussions, they indicated that the debate approach had added a new dimension to their evidence-based medicine skills by adding purpose and motivation. However, they felt that their performances would have been better if they had been offered practical demonstrations of how to conduct the debate. The participants indicated that the KTP enhanced their understanding of the relationships between evidence

Creative design inspired by biological knowledge: Technologies and methods

Science.gov (United States)

Tan, Runhua; Liu, Wei; Cao, Guozhong; Shi, Yuan

2018-05-01

Biological knowledge is becoming an important source of inspiration for developing creative solutions to engineering design problems and even has a huge potential in formulating ideas that can help firms compete successfully in a dynamic market. To identify the technologies and methods that can facilitate the development of biologically inspired creative designs, this research briefly reviews the existing biological-knowledge-based theories and methods and examines the application of biological-knowledge-inspired designs in various fields. Afterward, this research thoroughly examines the four dimensions of key technologies that underlie the biologically inspired design (BID) process. This research then discusses the future development trends of the BID process before presenting the conclusions.

Microautoradiographic methods and their applications in biology

International Nuclear Information System (INIS)

Benes, L.

1978-01-01

A survey of microautoradiographic methods and of their application in biology is given. The current state of biological microautoradiography is shown, focusing on the efficiency of techniques and on special problems proceeding in autoradiographic investigations in biology. Four more or less independent fields of autoradiography are considered. In describing autoradiographic techniques two methodological tasks are emphasized: The further development of the labelling technique in all metabolic studies and of instrumentation and automation of autoradiograph evaluation. (author)

Innovation

DEFF Research Database (Denmark)

Nielsen, Janni; Yaganeh, Suzanne; Bloch Rasmussen, Leif

2013-01-01

This paper contributes to a theoretical discussion of creation of innovation with participants in, or outside, organisations. We address the creation of innovation with a complex theoretical understanding drawing on the Scandinavian and the Participatory Design tradition introducing two approaches...... to the processes of innovation. We ask if innovation can be initiated and enhanced looking at two collaborative approaches; participatory innovation (PIN) and cooperative innovation (COIN). We invite to dialogue and reflections on PIN’s conflict and creative frictions on one side and COIN’s complexity......, complementarity in diversity and the didactic scaffolding of the innovation process on the other side. Our contribution focuses on the methods and practices for facilitation of co-creating activities between different groups leading to cooperation, and innovation in thinking....

The Method of Relative Evaluations in the Analysis of the Innovation and Scientific-Technical Activity in the National Innovation System

Directory of Open Access Journals (Sweden)

Melnyk Alexander G.

2017-04-01

Full Text Available The article suggests the methodical approach to calculation of the system of analytical indicators for complex analysis of the innovation and scientific-technical activity by defining indexes such as: implementarity of technologies; institutional fullness of the national innovation system (NIS; high technology grade of the industry branches and sectors of the NIS. Fundamentals on the interpretation of these indicators in determining the status of institutional and technological structures, as well as the investment ability of technologies in the NIS, have been formulated. An evaluation of status of the innovation and scientific-technical activity in the industry and in the sector of scientific organizations of Ukraine was carried out on the example of practical application of the methodical approach to the analysis of statistical data. A simulation of the calculation index of implementarity of technologies in terms of the hypothesis of a 10 x magnification of the number of patents for inventions was completed. The author’s own interpretation of values of the calculated indicators has been proposed.

Systems biology solutions for biochemical production challenges

DEFF Research Database (Denmark)

Hansen, Anne Sofie Lærke; Lennen, Rebecca M; Sonnenschein, Nikolaus

2017-01-01

There is an urgent need to significantly accelerate the development of microbial cell factories to produce fuels and chemicals from renewable feedstocks in order to facilitate the transition to a biobased society. Methods commonly used within the field of systems biology including omics...... characterization, genome-scale metabolic modeling, and adaptive laboratory evolution can be readily deployed in metabolic engineering projects. However, high performance strains usually carry tens of genetic modifications and need to operate in challenging environmental conditions. This additional complexity...... compared to basic science research requires pushing systems biology strategies to their limits and often spurs innovative developments that benefit fields outside metabolic engineering. Here we survey recent advanced applications of systems biology methods in engineering microbial production strains...

Innovation: an emerging focus from cells to societies.

Science.gov (United States)

Hochberg, Michael E; Marquet, Pablo A; Boyd, Robert; Wagner, Andreas

2017-12-05

Innovations are generally unexpected, often spectacular changes in phenotypes and ecological functions. The contributions to this theme issue are the latest conceptual, theoretical and experimental developments, addressing how ecology, environment, ontogeny and evolution are central to understanding the complexity of the processes underlying innovations. Here, we set the stage by introducing and defining key terms relating to innovation and discuss their relevance to biological, cultural and technological change. Discovering how the generation and transmission of novel biological information, environmental interactions and selective evolutionary processes contribute to innovation as an ecosystem will shed light on how the dominant features across life come to be, generalize to social, cultural and technological evolution, and have applications in the health sciences and sustainability.This article is part of the theme issue 'Process and pattern in innovations from cells to societies'. © 2017 The Author(s).

Proposal of system for work with innovative ideas, opportunities and innovations in the company

Directory of Open Access Journals (Sweden)

Viliam Lendel

2013-01-01

Full Text Available The paper is based on a detailed analysis of literature and conducted research to create a system for work with innovative ideas, opportunities and innovations in company. This paper reports the main results of the research that authors conducted on a sample of 318 respondents. Main purpose of the research was to identify the key elements of the use of innovation in marketing management system for work with innovation, opportunities, knowledge and application of lateral thinking. This paper deals with the identification of the main preconditions for successful use of the proposed system for work with innovative ideas, opportunities and innovations in business. Attention is also paid to the identification of the most common problems in the use of innovation and innovative ideas in business. The paper presents a series of recommendations to minimize the described problems and serves valuable tool for marketing manager for the efficient use of labour with innovative ideas, opportunities, innovation and expertise in the company. Following methods were used for research: comparative method of qualitative evaluation method, the method of structured and structured interviews, observation method, the method of document analysis (method of content analysis and questionnaire method.

Biology, Philosophy, and Scientific Method.

Science.gov (United States)

Hill, L.

1985-01-01

The limits of falsification are discussed and the historically based models of science described by Lakatos and Kuhn are shown to offer greater insights into the practice of science. The theory of natural selection is used to relate biology to philosophy and scientific method. (Author/JN)

Biologicals versus biosimilars the future ahead

Directory of Open Access Journals (Sweden)

A Singhal

2015-01-01

Full Text Available Biosimilars are highly similar versions of already authorized innovator biological therapies. They demonstrate no clinically meaningful difference with their innovator products in terms of efficacy, safety and quality characteristics and biological activity. Biosimilars have demonstrated growing acceptance and use, especially in the developing countries due to severe cost constraints. Global market for Indian non-innovator products is approximately worth USD 1.5 Billion/annum with an annual growth rate of 27%. Estimated exports of Indian biopharmaceutical products have been increasing at a rate of 47%. In India, there is a good acceptance of non-innovator healthcare products amongst healthcare professionals and patients. Several home grown biopharmaceutical industries are now actively developing and marketing non innovator products in India.

Group Innovation Ability of Agricultural Technological Innovation Strategic Alliance

Institute of Scientific and Technical Information of China (English)

Chishun; MA; Jintian; YU

2013-01-01

Agricultural technological innovation strategic alliance, as an important form of strategic alliance, has steadily strengthened the collaborative management among organizations and raised competitive power with the backing of improved group innovation ability. This article studies innovation ability from individual innovation ability to the group innovation ability. Firstly, basic connotation of group innovation ability is to be concluded through the comparison of individual and group innovation ability. Secondly, evaluation index system is to be established based on the influencing factors of the group innovation ability of agricultural technological innovation strategic alliance and evaluation is based on three dimensions, namely organization technological innovation ability, alliance collaborative innovation ability as well as innovation environment. Furthermore, basic methods for promoting the group innovation ability of alliance are to be proposed.

Simple Calculation Programs for Biology Immunological Methods

Indian Academy of Sciences (India)

First page Back Continue Last page Overview Graphics. Simple Calculation Programs for Biology Immunological Methods. Computation of Ab/Ag Concentration from EISA data. Graphical Method; Raghava et al., 1992, J. Immuno. Methods 153: 263. Determination of affinity of Monoclonal Antibody. Using non-competitive ...

Building biological foundries for next-generation synthetic biology.

Science.gov (United States)

Chao, Ran; Yuan, YongBo; Zhao, HuiMin

2015-07-01

Synthetic biology is an interdisciplinary field that takes top-down approaches to understand and engineer biological systems through design-build-test cycles. A number of advances in this relatively young field have greatly accelerated such engineering cycles. Specifically, various innovative tools were developed for in silico biosystems design, DNA de novo synthesis and assembly, construct verification, as well as metabolite analysis, which have laid a solid foundation for building biological foundries for rapid prototyping of improved or novel biosystems. This review summarizes the state-of-the-art technologies for synthetic biology and discusses the challenges to establish such biological foundries.

Innovation camp as a method in health education

DEFF Research Database (Denmark)

Duus, Lene; Ringby, Betina

2017-01-01

Society calls for creative, innovative and enterprising health professionals who also have abilities to work interdisciplinary. New learning methods are required to develop new skills. Health care students must develop mind-sets and skills that enable them to create, develop and take action upon...... new services in new or existing organisations. Students also need to develop skills for interdisciplinary collaboration and develop their own knowledge of different cultures and behaviours. Therefore, educational institutions must challenge students in many different ways....

Biological methods used to assess surface water quality

Directory of Open Access Journals (Sweden)

Szczerbiñska Natalia

2015-12-01

Full Text Available In accordance with the guidelines of the Water Framework Directive 2000/60 (WFD, both ecological and chemical statuses determine the assessment of surface waters. The profile of ecological status is based on the analysis of various biological components, and physicochemical and hydromorphological indicators complement this assessment. The aim of this article is to present the biological methods used in the assessment of water status with a special focus on bioassay, as well as to provide a review of methods of monitoring water status. Biological test methods include both biomonitoring and bioanalytics. Water biomonitoring is used to assess and forecast the status of water. These studies aim to collect data on water pollution and forecast its impact. Biomonitoring uses organisms which are characterized by particular vulnerability to contaminants. Bioindicator organisms are algae, fungi, bacteria, larval invertebrates, cyanobacteria, macroinvertebrates, and fish. Bioanalytics is based on the receptors of contaminants that can be biologically active substances. In bioanalytics, biosensors such as viruses, bacteria, antibodies, enzymes, and biotests are used to assess degrees of pollution.

The increasing of national competitiveness. The methodology of training the innovators

Directory of Open Access Journals (Sweden)

Alexandru GRIBINCEA

2017-06-01

Full Text Available According to the dictionary, an innovator is someone who performs and introduces something new in a field; person who brings an innovation in the production sector, resulting in improved quality and quantity of the work. Often innovator is a highly-qualified specialist, able to generate innovative offers in some areas having a positive impact. The author refers to multiple information and knowledge from different fields and applied sciences such as mathematics, physics, biology, chemistry, philosophy, economics, political science and law in the elaboration of innovative offers. According to these requirements, the innovator must have knowledge in these fields of science and practice. The aim of the research is to reveal some elements in the development and implementation of innovations as knowledge in various fields of science and technology, physics, chemistry, biology, and other fields necessary for innovators.

Current status and trends, organizational methods accounting and analysis of innovative enterprises’ venture financing

Directory of Open Access Journals (Sweden)

S.V. Rudeychuk

2016-09-01

Full Text Available The article examines the specific features and tendencies of development of venture financing in Ukraine. It shows the role of venture capital in the further development of Ukraine economy, this role is in financing and development of innovation, distribution of new technologies and increase of employment of highly professional staff in the territory of Ukraine. The authors determine the influence of characteristics of such financing on the formation of organization and methods of accounting and economic analysis of operations with venture capital investments. The paper grounds the necessity of accounting development and analytical support of innovative enterprises’ venture financing management; the state is caused by the need to attract additional funding from venture investors to finance the production and release of innovative products and businesses. The authors determine the directions of solving problems in accounting organization and methods and economic analysis of innovative enterprises’ venture financing, respectively, for the needs of all entities doing business venture and taking into account the peculiarities of this type of investment capital.

Innovative Calibration Method for System Level Simulation Models of Internal Combustion Engines

Directory of Open Access Journals (Sweden)

Ivo Prah

2016-09-01

Full Text Available The paper outlines a procedure for the computer-controlled calibration of the combined zero-dimensional (0D and one-dimensional (1D thermodynamic simulation model of a turbocharged internal combustion engine (ICE. The main purpose of the calibration is to determine input parameters of the simulation model in such a way as to achieve the smallest difference between the results of the measurements and the results of the numerical simulations with minimum consumption of the computing time. An innovative calibration methodology is based on a novel interaction between optimization methods and physically based methods of the selected ICE sub-systems. Therein physically based methods were used for steering the division of the integral ICE to several sub-models and for determining parameters of selected components considering their governing equations. Innovative multistage interaction between optimization methods and physically based methods allows, unlike the use of well-established methods that rely only on the optimization techniques, for successful calibration of a large number of input parameters with low time consumption. Therefore, the proposed method is suitable for efficient calibration of simulation models of advanced ICEs.

Methods for Practising Ethics in Research and Innovation : A Literature Review, Critical Analysis and Recommendations

NARCIS (Netherlands)

Reijers, Wessel; Wright, David; Brey, Philip; Weber, Karsten; Rodrigues, Rowena; O’Sullivan, Declan; Gordijn, Bert

2017-01-01

This paper provides a systematic literature review, analysis and discussion of methods that are proposed to practise ethics in research and innovation (R&I). Ethical considerations concerning the impacts of R&I are increasingly important, due to the quickening pace of technological innovation and

Shoreline clean-up methods : biological treatments

Energy Technology Data Exchange (ETDEWEB)

Massoura, S.T. [Oil Spill Response Limited, Southampton (United Kingdom)

2009-07-01

The cleanup of oil spills in shoreline environments is a challenging issue worldwide. Oil spills receive public and media attention, particularly in the event of a coastal impact. It is important to evaluate the efficiency and effectiveness of cleanup methods when defining the level of effort and consequences that are appropriate to remove or treat different types of oil on different shoreline substrates. Of the many studies that have compared different mechanical, chemical and biological treatments for their effectiveness on various types of oil, biological techniques have received the most attention. For that reason, this paper evaluated the effectiveness and effects of shoreline cleanup methods using biological techniques. It summarized data from field experiments and oil spill incidents, including the Exxon Valdez, Sea Empress, Prestige, Grand Eagle, Nakhodka, Guanabara Bay and various Gulf war oil spills. Five major shoreline types were examined, notably rocky intertidal, cobble/pebble/gravel, sand/mud, saltmarsh, and mangrove/sea-grass. The biological techniques that were addressed were nutrient enrichment, hydrocarbon-utilizing bacteria, vegetable oil biosolvents, plants, surf washing, oil-particle interactions and natural attenuation. The study considered the oil type, volume and fate of stranded oil, location of coastal materials, extent of pollution and the impact of biological techniques. The main factors that affect biodegradation of hydrocarbons are the volume, chemical composition and weathering state of the petroleum product as well as the temperature, oxygen availability of nutrients, water salinity, pH level, water content, and microorganisms in the shoreline environment. The interaction of these factors also affect the biodegradation of oil. It was concluded that understanding the fate of stranded oil can help in the development of techniques that improve the weathering and degradation of oil on complex shoreline substrates. 39 refs.

Forms and methods of stimulation of innovative activities in the restructuring of production program

Directory of Open Access Journals (Sweden)

I. I. Emtcova

2016-01-01

Full Text Available In the Russian economy not every business entity, implements innovative business activities. The situation generated by the complexity of perception and practical transition to an innovative economic system. On the development of innovative activities affects the overall condition of the economy, condition of material production. The research demonstrates that resource potential of innovative activities in recent years had a tendency towards absolute quantitative reduction and quality deterioration. The decrease in the level and quality of resource provision of innovative activity due to the lack of necessary financial resources. Currently, innovation has become the primary means of increasing the profit of economic entities at the expense of better meet market demand, reduce production costs compared to competitors. Given the complexity of businesses, there is a need of the state stimulation of innovative activity, which is carried out the main directions, forms and methods. In the system of direct effects of the state on business innovation is the stimulation of development of Technopark structures. Creating the most favourable conditions for innovative enterprises, the provision of various services is their main goal. For the food processing industry currently, the largest share in the investments in the investment activities have their own sources of funding, including the use of depreciation. To Finance industry-wide, cross-sectoral and regional scientific and technical problems you can create extra-budgetary funds for financing R & d and innovation support. To encourage regional interests, one of which is that innovation is available to local authorities. In the financial provision of innovative activity is given credit. A Bank loan allows you to increase the efficiency of innovation activity. The article concludes that these measures to stimulate innovative-innovative activity can effectively influence the activity of the company: will

Student Characteristics, Prior Experiences, and the Perception of Mixed Methods as an Innovation

Science.gov (United States)

Brown, Sydney E.

2014-01-01

There are persistent challenges to teaching mixed methods and innovative solutions are sought in order to address the needs of an increasingly diverse global audience seeking mixed methods instruction. This mixed methods study was conducted to gain insights to course design by more fully understanding the relationships among graduate student…

Simple Calculation Programs for Biology Methods in Molecular ...

Indian Academy of Sciences (India)

First page Back Continue Last page Overview Graphics. Simple Calculation Programs for Biology Methods in Molecular Biology. GMAP: A program for mapping potential restriction sites. RE sites in ambiguous and non-ambiguous DNA sequence; Minimum number of silent mutations required for introducing a RE sites; Set ...

IMPLEMENTASI METODE INQUIRY UNTUK MENINGKATKAN HASIL BELAJAR BIOLOGI

Directory of Open Access Journals (Sweden)

T. H. Agustanti

2012-04-01

Full Text Available Tujuan penelitian ini adalah untuk meningkatkan hasil belajar biologi pada siswa kelas VIIE SMP N 2 Wonosobo semester 1 tahun pelajaran 2010/2011 pada mata pelajaran biologi melalui Implementasi Metode Inquiry. Dari hasil penelitian dapat disimpulkan bahwa Implementasi Metode Inquiry dapat meningkatkan hasil belajar siswa pada mata pelajaran Biologi. Dari penelitian ini disarankan agar guru-guru mencari inovasi-inovasi baru yang dapat merangsang sehingga proses pembelajaran lebih bermakna. The purpose of this research is to improve the learning result for first semester students of SMP N 2 Wonosobo VIIE class in the academic year 2010/2011 in the Biology subject using Inquiry method. From the research, it can be concluded that the implementation of Inquiry method can improve the learning result in the Biology subject. Base don the research result it can be suggested that the teacher can find the new innovation to stimulate students’ motivation in order to make the learning process to be more significant.

Method-centered digital communities on protocols.io for fast-paced scientific innovation.

Science.gov (United States)

Kindler, Lori; Stoliartchouk, Alexei; Teytelman, Leonid; Hurwitz, Bonnie L

2016-01-01

The Internet has enabled online social interaction for scientists beyond physical meetings and conferences. Yet despite these innovations in communication, dissemination of methods is often relegated to just academic publishing. Further, these methods remain static, with subsequent advances published elsewhere and unlinked. For communities undergoing fast-paced innovation, researchers need new capabilities to share, obtain feedback, and publish methods at the forefront of scientific development. For example, a renaissance in virology is now underway given the new metagenomic methods to sequence viral DNA directly from an environment. Metagenomics makes it possible to "see" natural viral communities that could not be previously studied through culturing methods. Yet, the knowledge of specialized techniques for the production and analysis of viral metagenomes remains in a subset of labs.  This problem is common to any community using and developing emerging technologies and techniques. We developed new capabilities to create virtual communities in protocols.io, an open access platform, for disseminating protocols and knowledge at the forefront of scientific development. To demonstrate these capabilities, we present a virology community forum called VERVENet. These new features allow virology researchers to share protocols and their annotations and optimizations, connect with the broader virtual community to share knowledge, job postings, conference announcements through a common online forum, and discover the current literature through personalized recommendations to promote discussion of cutting edge research. Virtual communities in protocols.io enhance a researcher's ability to: discuss and share protocols, connect with fellow community members, and learn about new and innovative research in the field.  The web-based software for developing virtual communities is free to use on protocols.io. Data are available through public APIs at protocols.io.

Innovative development and factors affecting the innovative activity of industrial enterprises in Bulgaria

Directory of Open Access Journals (Sweden)

Sotirova Asya Olegova

2016-12-01

Full Text Available Innovations are a necessity, innovations are a factor, innovations are the moving force of the companies in the 21st century. Every modern manager should recognize the role of innovations for the existence of the enterprises and to aim at innovative development. The novelties in various areas are to be followed up. It is necessary to look for the options and to overcome the obstacles standing in the way of innovations. The major objective of this article is to establish the state of innovative activity of industrial enterprises in Bulgaria and to identify the factors exercising the largest influence on their innovative development. The major results to be achieved are the establishment of the basic internal and external factors that support innovations, the deduction of the major problems occurring during the innovation process and the establishment of some directives to activation. The major methods of study used in this work are statistical methods for evaluation, method of analysis and synthesis, method of comparison. Information of literature sources has been studied and systematized within the process of research, as well as analytical reports of Bulgaria and the European Union, and results from an inquiry held are used, as well as statistical data of the National Statistical Institute of the Republic of Bulgaria.

Systems biology solutions for biochemical production challenges.

Science.gov (United States)

Hansen, Anne Sofie Lærke; Lennen, Rebecca M; Sonnenschein, Nikolaus; Herrgård, Markus J

2017-06-01

There is an urgent need to significantly accelerate the development of microbial cell factories to produce fuels and chemicals from renewable feedstocks in order to facilitate the transition to a biobased society. Methods commonly used within the field of systems biology including omics characterization, genome-scale metabolic modeling, and adaptive laboratory evolution can be readily deployed in metabolic engineering projects. However, high performance strains usually carry tens of genetic modifications and need to operate in challenging environmental conditions. This additional complexity compared to basic science research requires pushing systems biology strategies to their limits and often spurs innovative developments that benefit fields outside metabolic engineering. Here we survey recent advanced applications of systems biology methods in engineering microbial production strains for biofuels and -chemicals. Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.

An Innovative Teaching Method To Promote Active Learning: Team-Based Learning

Science.gov (United States)

Balasubramanian, R.

2007-12-01

Traditional teaching practice based on the textbook-whiteboard- lecture-homework-test paradigm is not very effective in helping students with diverse academic backgrounds achieve higher-order critical thinking skills such as analysis, synthesis, and evaluation. Consequently, there is a critical need for developing a new pedagogical approach to create a collaborative and interactive learning environment in which students with complementary academic backgrounds and learning skills can work together to enhance their learning outcomes. In this presentation, I will discuss an innovative teaching method ('Team-Based Learning (TBL)") which I recently developed at National University of Singapore to promote active learning among students in the environmental engineering program with learning abilities. I implemented this new educational activity in a graduate course. Student feedback indicates that this pedagogical approach is appealing to most students, and promotes active & interactive learning in class. Data will be presented to show that the innovative teaching method has contributed to improved student learning and achievement.

Simple Calculation Programs for Biology Other Methods

Indian Academy of Sciences (India)

First page Back Continue Last page Overview Graphics. Simple Calculation Programs for Biology Other Methods. Hemolytic potency of drugs. Raghava et al., (1994) Biotechniques 17: 1148. FPMAP: methods for classification and identification of microorganisms 16SrRNA. graphical display of restriction and fragment map of ...

Innovation through accelerators: A case for open innovation

Directory of Open Access Journals (Sweden)

Lerato E. Mohalajeng

2016-12-01

Full Text Available Background: Open innovation is becoming a progressive business practice in Southern Africa because it plays a significant role in economic development through promoting the commercialisation of new ideas. The challenge is that while the benefits of open innovation are widely spoken about, not much is understood about the challenges and successes of open innovation accelerators (OIAs in taking ideas to market. Aim: The purpose of this research was to investigate an OIA in South Africa for taking ideas to market. Setting: The Innovation Hub is a science park in Pretoria, South Africa, using open innovation to stimulate entrepreneurship in South Africa. Through The Innovation Hub Open IX, a webbased platform, an opportunity to investigate the bridging from invention to commercialisation is presented. Methods: A qualitative research method using semi-structured, in-depth interviews was applied to collect data. Five key stakeholders of the OIA were interviewed. Results: The findings suggest that stakeholder buy-in is essential for commercialisation through OIAs in South Africa. By involving stakeholders in the initial phases of the open innovation process, the likelihood of a solution being incorporated and fitted into the organisation’s business strategy is increased. Conclusion: The insight gained from this research suggests policymakers, research institutions and commercial businesses ought to explore various innovations across industries relevant to their open innovation proficiencies. This research makes a significant contribution to an indepth understanding of what is needed to bridge the gap from invention to successful commercialisation through open innovation.

Methods to Implement Innovation and Entrepreneurship in Physics

Science.gov (United States)

Arion, Douglas

2015-03-01

The physics community is beginning to become aware of the benefits of entrepreneurship and innovation education: greater enrollments, improved students satisfaction, a wider range of interesting research problems, and the potential for greater return from more successful alumni. This talk will suggest a variety of mechanisms by which physics departments can include entrepreneurship and innovation content within their programs - without necessarily requiring earth-shattering changes to the curriculum. These approaches will thus make it possible for departments to get involved with entrepreneurship and innovation, and grow those components into vibrant activities for students and faculty.

Stimulating Creativity Methods And Innovative Performance In European Countries

Directory of Open Access Journals (Sweden)

Şipoş Gabriela Lucia

2015-06-01

Full Text Available A widely debated topic during the last decades focuses on the companies’ opportunities to acquire corporate competitiveness due to research, innovation and development. Thus, in the context of increased competition and current global challenges, fostering creativity and innovation is a way to boost economic growth and welfare of European countries. New and original ideas, skills, competencies and innovations they all could enable to achieve competitive advantages. Creative ideas and innovative solutions are crucial for the European countries in order to overcome the current economic crisis.

Estimating the direction of innovative change based on theory an mixed methods

NARCIS (Netherlands)

Geurts, Petrus A.T.M.; Roosendaal, Hans E.

2001-01-01

In predicting the direction of innovative changethe question arises of the valid measurement ofyet unknown variables. We developed and applied aresearch method that combines qualitativeand quantitative elements in one interview formatand an analysis tool suitable for these data. Animportant

Mixed-Methods Design in Biology Education Research: Approach and Uses.

Science.gov (United States)

Warfa, Abdi-Rizak M

Educational research often requires mixing different research methodologies to strengthen findings, better contextualize or explain results, or minimize the weaknesses of a single method. This article provides practical guidelines on how to conduct such research in biology education, with a focus on mixed-methods research (MMR) that uses both quantitative and qualitative inquiries. Specifically, the paper provides an overview of mixed-methods design typologies most relevant in biology education research. It also discusses common methodological issues that may arise in mixed-methods studies and ways to address them. The paper concludes with recommendations on how to report and write about MMR. © 2016 L. A.-R. M. Warfa. CBE—Life Sciences Education © 2016 The American Society for Cell Biology. This article is distributed by The American Society for Cell Biology under license from the author(s). It is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

Medical innovation laws: an unnecessary innovation.

Science.gov (United States)

Richards, Bernadette

2016-06-01

Objective This paper aims to demonstrate that any suggestion that there is a need for specific innovation laws is flawed. Innovation is central to good medical practice and is adequately supported by current law. Methods The paper reviews the nature of medical innovation and outlines recent attempts in the UK to introduce specific laws aimed at 'encouraging' and 'supporting' innovation. The current legal framework is outlined and the role of the law in relation to medical innovation explored. Results The analysis demonstrates the cyclic relationship between medical advancement and the law and concludes that there is no requirement for specific innovation laws. Conclusions The law not only supports innovation and development in medical treatment but encourages it as central to a functioning medical system. There is no need to introduce specific laws aimed at medical innovation; to do so represents an unnecessary legal innovation and serves to complicate matters. What is known about the topic? Over recent months, there has been a great deal of discussion surrounding the law in the context of medical innovation. This was driven by the attempts in the UK to introduce specific laws in the Medical Innovation Bill. The general subject matter - negligence and the expected standard of care in the provision of treatment - is very well understood, but not in cases where the treatment can be described as innovative. The general rhetoric in both the UK and Australia around the Medical Innovation Bill demonstrates a lack of understanding of the position of the law with regards to innovative treatment. What does this paper add? This paper adds clarity to the debate. It presents the law and explains the manner in which the law can operate around innovative treatment. The paper asserts that medical innovation is both supported and encouraged by existing legal principles. What are the implications for practitioners? The paper presents an argument that can guide the policy position

Innovating Science Teaching by Participatory Action Research--Reflections from an Interdisciplinary Project of Curriculum Innovation on Teaching about Climate Change

Science.gov (United States)

Feierabend, Timo; Eilks, Ingo

2011-01-01

This paper describes a three-year curriculum innovation project on teaching about climate change. The innovation for this study focused on a socio-critical approach towards teaching climate change in four different teaching domains (biology, chemistry, physics and politics). The teaching itself explicitly aimed at general educational objectives,…

Marketing Innovations in Croatia

Directory of Open Access Journals (Sweden)

Ljiljana Božić

2011-06-01

Full Text Available The purpose of this paper is to analyze the introduction of marketing innovations by companies in Croatia. This study provides an insight into the innovativeness with regard to the introduction of marketing innovations. It explores the presence of marketing innovations in general and the introduction of four types of marketing innovation (significant changes to the aesthetic design or packaging, new media or techniques for product promotion, new methods for product placement or sales channels and new methods of pricing goods or services. The changes in all four elements of the marketing mix are described. The paper also explores the extent to which the introduction of marketing innovation is related to the companies that introduce other types of innovations.

MEMBRANE TECHNOLOGIES — AN INNOVATIVE METHOD OF PROTEIN BIOLOGICAL VALUE INCREASING IN YOUNG CHILDREN FEEDING

Directory of Open Access Journals (Sweden)

I. V. Gmoshinskii

2012-01-01

Full Text Available A qualitatively new approach to protein production for milk formulas for infants is discussed in this article. The advantage of membrane technologies usage is that they allow preserving protein biological value and make it possible to control the levels of amino-acids in protein by optimizing their proportion and quantity.

The Business Engineering Surgical Technologies (BEST) teaching method: incubating talents for surgical innovation.

Science.gov (United States)

de Ruijter, V; Halvax, P; Dallemagne, B; Swanström, L; Marescaux, J; Perretta, S

2015-01-01

Technological innovation in surgical science and healthcare is vital and calls for close collaboration between engineering and surgery. To meet this objective, BEST was designed as a free sustainable innovative teaching method for young professionals, combining surgery, engineering, and business in a multidisciplinary, high-quality, low-cost, and learning-by-doing philosophy. This paper reviews the initial outcomes of the program and discusses lessons learned and future directions of this innovative educational method. BEST educational method is delivered in two parts: the first component consisting of live streaming or pre-recorded online lectures, with an interdisciplinary profile focused on surgery, engineering, and business. The second component is an annual 5-day on-site course, organized at IRCAD-IHU, France. The program includes workshops in engineering, entrepreneurship team projects, and in-depth hands-on experience in laparoscopy, robotic surgery, interventional radiology, and flexible endoscopy with special emphasis on the interdisciplinary aspect of the training. A panel of surgeons, engineers, well-established entrepreneurs, and scientists assessed the team projects for potential patent application. From November 2011 till September 2013, 803 individual and institutional users from 79 different countries attended the online course. In total, 134 young professionals from 32 different countries applied to the onsite course. Sixty participants were selected each year for the onsite course. In addition, five participants were selected for a web-based team. Thirteen provisional patents were filed for the most promising projects. BEST proved to be a global talent incubator connecting students to high-quality education despite institutional and economical boundaries. Viable and innovative ideas arose from this revolutionary approach which is likely to spin-off significant technology transfer and lead the way for future interdisciplinary hybrid surgical

Multi-objective genetic algorithm based innovative wind farm layout optimization method

International Nuclear Information System (INIS)

Chen, Ying; Li, Hua; He, Bang; Wang, Pengcheng; Jin, Kai

2015-01-01

Highlights: • Innovative optimization procedures for both regular and irregular shape wind farm. • Using real wind condition and commercial wind turbine parameters. • Using multiple-objective genetic algorithm optimization method. • Optimize the selection of different wind turbine types and their hub heights. - Abstract: Layout optimization has become one of the critical approaches to increase power output and decrease total cost of a wind farm. Previous researches have applied intelligent algorithms to optimizing the wind farm layout. However, those wind conditions used in most of previous research are simplified and not accurate enough to match the real world wind conditions. In this paper, the authors propose an innovative optimization method based on multi-objective genetic algorithm, and test it with real wind condition and commercial wind turbine parameters. Four case studies are conducted to investigate the number of wind turbines needed in the given wind farm. Different cost models are also considered in the case studies. The results clearly demonstrate that the new method is able to optimize the layout of a given wind farm with real commercial data and wind conditions in both regular and irregular shapes, and achieve a better result by selecting different type and hub height wind turbines.

Innovative methods in teaching mathematics

OpenAIRE

Чепелева, Т. И.

2013-01-01

The report outlines the main directions of innovation in the teaching of higher mathematics at the university. The basic technological approach is suggested when creating lecture presentations such as their color characteristics of fonts, the amount of information on a slide, etc., which is based on teaching experience and is suitable for development of other educational presentations.

Logistic innovations in transport

Directory of Open Access Journals (Sweden)

Mirosław Antonowicz

2014-03-01

Full Text Available Introduction: The article discusses the issue of logistic innovations in transport. The essentials of logistic innovations in transport together with some examples of specific innovations are presented. The role of the client's needs in transport innovations is indicated. The most vital postulates affecting the innovativeness of shipping companies and derived from the author's experience as well as scholarly publications, are time, safety, reliability as well as comprehensiveness of service offer. Following the analysis of the issue, and on the grounds of Kaizen's and Lean's method, the concept of continuous innovations is suggested as very useful for the development of transport. The potential of clusters as the source of logistic innovations in transport is emphasised. Methods: The discussion of the issue was preceded by the author's analysis of written sources on innovativeness, the evaluation of ratings of innovativeness as well as the analysis of rewarded innovative solutions in transport subsequent to the businesses participation in the programme of innovative solutions in transport. The role of innovation practical business operations is argued following the analysis of some strategic documents such as: 2011 White Paper and the Strategy for the Development of Transport by 2020 adopted by the Polish government in 2013. Aim: The aim of the article is to present the role and significance of the issue of logistic innovations in transport and to cite instances of practical solutions implemented by shipping companies, the solutions which resulted in measurable effects. Following the author's observation of the instances of innovative solutions as well as his analysis of the ratings of innovativeness, the article aims to present the conclusions as for the specific kinds of activities which are indispensable to foster innovativeness in transport. Conclusions: The conclusions derived from the author's analyses and observations show that logistic

METHODICS, SOFTWARE AND LABORATORY EQUIPMENT FOR AN INNOVATIVE ELECTRICAL ENGINEERING DISCIPLINE

Directory of Open Access Journals (Sweden)

V.S. Petrushin

2016-09-01

Full Text Available Purpose. Development of innovative electrical engineering discipline «Electric Machines in Mechatronic Systems» in order to improve the training of specialists of electrical engineering specialty. Methodology. The proposed project concerns the educational reforms that promote the intensification of the educational process. Results. The structure of interactive educational and training complex, which is a computer learning tool in the form of software and methodical support, as well as data and knowledge bases and consists of functionally related multimedia learning systems, interactive learning, automated control of the learning process. Originality. To offer online training and research facilities, guidelines for laboratory and computational and graphic works. Practical value. Increase the knowledge of students of educational material related to the discipline of innovation «Electric Machines in Mechatronic Systems».

Handbook of design research methods in education innovations in science, technology, engineering, and mathematics learning and teaching

CERN Document Server

Lesh, Richard A; Baek, John Y

2008-01-01

This Handbook presents the latest thinking and current examples of design research in education. Design-based research involves introducing innovations into real-world practices (as opposed to constrained laboratory contexts) and examining the impact of those designs on the learning process. Designed prototype applications (e.g., instructional methods, software or materials) and the research findings are then cycled back into the next iteration of the design innovation in order to build evidence of the particular theories being researched, and to positively impact practice and the diffusion of the innovation. The Handbook of Design Research Methods in Education-- the defining book for the field -- fills a need in how to conduct design research by those doing so right now. The chapters represent a broad array of interpretations and examples of how today's design researchers conceptualize this emergent methodology across areas as diverse as educational leadership, diffusion of innovations, complexity theory, an...

Innovation in Healthcare Delivery: Commentary on an Evolutionary Approach.

Science.gov (United States)

Fields, Anthony L A

2015-01-01

Zwarenstein (2015) proposes a novel approach to healthcare innovation that parallels biological evolution, based on stimulation and reward of multiple small competing innovation projects conducted in the field by decentralized teams. Projects would be designed with explicit outcome targets and results would be widely disseminated and publicly available. More successful projects would be grown and spread. Critical to the model is accepting and reporting failure as well as success, for the benefit of future project design. Examining biological evolution for lessons for healthcare delivery innovation illuminates the need for diversity among healthcare systems to achieve optimum application of best practice interventions across jurisdictions with differing population, provider and facility characteristics. However, careful coordination will be needed to achieve the balance between diversity and harmony across jurisdictions necessary for effective governance and interaction. There are important methodological issues to be addressed to reduce the uncertainty inherent in comparisons of results among discrete innovation projects, especially when observed improvements over the baseline are modest. As well as evolutionary improvement in healthcare outcomes, the model should progressively increase decentralized capacity and expertise in innovation processes.

Quantitative stem cell biology: the threat and the glory.

Science.gov (United States)

Pollard, Steven M

2016-11-15

Major technological innovations over the past decade have transformed our ability to extract quantitative data from biological systems at an unprecedented scale and resolution. These quantitative methods and associated large datasets should lead to an exciting new phase of discovery across many areas of biology. However, there is a clear threat: will we drown in these rivers of data? On 18th July 2016, stem cell biologists gathered in Cambridge for the 5th annual Cambridge Stem Cell Symposium to discuss 'Quantitative stem cell biology: from molecules to models'. This Meeting Review provides a summary of the data presented by each speaker, with a focus on quantitative techniques and the new biological insights that are emerging. © 2016. Published by The Company of Biologists Ltd.

Effectiveness of various innovative learning methods in health science classrooms: a meta-analysis.

Science.gov (United States)

Kalaian, Sema A; Kasim, Rafa M

2017-12-01

This study reports the results of a meta-analysis of the available literature on the effectiveness of various forms of innovative small-group learning methods on student achievement in undergraduate college health science classrooms. The results of the analysis revealed that most of the primary studies supported the effectiveness of the small-group learning methods in improving students' academic achievement with an overall weighted average effect-size of 0.59 in standard deviation units favoring small-group learning methods. The subgroup analysis showed that the various forms of innovative and reform-based small-group learning interventions appeared to be significantly more effective for students in higher levels of college classes (sophomore, junior, and senior levels), students in other countries (non-U.S.) worldwide, students in groups of four or less, and students who choose their own group. The random-effects meta-regression results revealed that the effect sizes were influenced significantly by the instructional duration of the primary studies. This means that studies with longer hours of instruction yielded higher effect sizes and on average every 1 h increase in instruction, the predicted increase in effect size was 0.009 standard deviation units, which is considered as a small effect. These results may help health science and nursing educators by providing guidance in identifying the conditions under which various forms of innovative small-group learning pedagogies are collectively more effective than the traditional lecture-based teaching instruction.

Evaluation of innovation processes

Directory of Open Access Journals (Sweden)

Jakub Tabas

2012-01-01

Full Text Available In present, innovations are spoken as an engine of the world economy because the innovations are transforming not only business entities but the whole industries. The innovations have become a necessity for business entities in order to survive on floating challenging markets. This way, innovations are driving force of companies’ performance. The problem which arises here is a question of measurement innovation’s effect on the financial performance of company or selection between two or more possible variants of innovation’s realization. Various authors which are focused on innovations processes are divided into two groups in their attitudes towards the question of influence of innovations on financial performance of companies. One group of the authors present the idea that any reliable measurement is not possible or efficient. The second group of authors present some methods theoretically applicable on this measurement but they base their approaches mostly on the methods of measurement of investments effectiveness or they suggest employment of indicators or ratios which wouldn’t be clearly connected with the outcome of innovation process. The aim of submitted article is to compare different approaches to evaluation of the innovation processes. The authors compare various approaches here and by use of analysis and synthesis, they determine their own method how to measure outcome of innovation process.

Heterogeneous update mechanisms in evolutionary games: Mixing innovative and imitative dynamics

Science.gov (United States)

Amaral, Marco Antonio; Javarone, Marco Alberto

2018-04-01

Innovation and evolution are two processes of paramount relevance for social and biological systems. In general, the former allows the introduction of elements of novelty, while the latter is responsible for the motion of a system in its phase space. Often, these processes are strongly related, since an innovation can trigger the evolution, and the latter can provide the optimal conditions for the emergence of innovations. Both processes can be studied by using the framework of evolutionary game theory, where evolution constitutes an intrinsic mechanism. At the same time, the concept of innovation requires an opportune mathematical representation. Notably, innovation can be modeled as a strategy, or it can constitute the underlying mechanism that allows agents to change strategy. Here, we analyze the second case, investigating the behavior of a heterogeneous population, composed of imitative and innovative agents. Imitative agents change strategy only by imitating that of their neighbors, whereas innovative ones change strategy without the need for a copying source. The proposed model is analyzed by means of analytical calculations and numerical simulations in different topologies. Remarkably, results indicate that the mixing of mechanisms can be detrimental to cooperation near phase transitions. In those regions, the spatial reciprocity from imitative mechanisms is destroyed by innovative agents, leading to the downfall of cooperation. Our investigation sheds some light on the complex dynamics emerging from the heterogeneity of strategy revision methods, highlighting the role of innovation in evolutionary games.

An Innovative SIFT-Based Method for Rigid Video Object Recognition

Directory of Open Access Journals (Sweden)

Jie Yu

2014-01-01

Full Text Available This paper presents an innovative SIFT-based method for rigid video object recognition (hereafter called RVO-SIFT. Just like what happens in the vision system of human being, this method makes the object recognition and feature updating process organically unify together, using both trajectory and feature matching, and thereby it can learn new features not only in the training stage but also in the recognition stage, which can improve greatly the completeness of the video object’s features automatically and, in turn, increases the ratio of correct recognition drastically. The experimental results on real video sequences demonstrate its surprising robustness and efficiency.

Syndicate Innovation Venturing: Translating Academic Innovations into Commercial Successes

Directory of Open Access Journals (Sweden)

Alain A. Vertès

2012-07-01

Full Text Available Innovations that initiate new technology cycles, i.e., radical innovations, bring tremendous value to Society and build for the companies that deploy them sustainable competitive advantages. However, large firms have typically been relatively inefficient at accessing from academia or technology start-ups such technological leaps. Indeed, most multiyear and multimillion dollar academia-industry partnerships have historically not resulted in any acceleration of the rate of deployment of game-changing innovations, which empirically proceeds in 25 year cycles, such as for example the expansion of the scope of the pharmaceutical industry from small molecules to biologics, or, projecting into the future, to siRNA or therapeutic stem cell technologies. Syndicated innovation venturing is a new strategic partnering concept described here that brings together actors from different economic segments in a non zero-sum game as a means to facilitate seed-funding, with the aim to de-risk technologies while reducing initial financial exposures. A case study in the pharmaceutical industry suggests that alleviating this hurdle may provide an appropriate environment to improve the dynamics of academic technology transfer to the commercial phase. By contributing to the de-risking of the creation of novel biotechnology businesses, this novel mechanism could help speed up the commercialization of emerging technologies on a large scale. At a time when knowledge-based firms such as pharmaceutical companies attempt to revisit their innovation models to advance science, in spite of an environment of increasing risk-aversion, such responses could tilt the balance in favor of disruptive products and sustained corporate financial performance by removing common barriers to radical innovation deployment.

Mixed-Methods Design in Biology Education Research: Approach and Uses

Science.gov (United States)

Warfa, Abdi-Rizak M.

2016-01-01

Educational research often requires mixing different research methodologies to strengthen findings, better contextualize or explain results, or minimize the weaknesses of a single method. This article provides practical guidelines on how to conduct such research in biology education, with a focus on mixed-methods research (MMR) that uses both quantitative and qualitative inquiries. Specifically, the paper provides an overview of mixed-methods design typologies most relevant in biology education research. It also discusses common methodological issues that may arise in mixed-methods studies and ways to address them. The paper concludes with recommendations on how to report and write about MMR. PMID:27856556

Participatory Innovation

DEFF Research Database (Denmark)

Buur, Jacob; Matthews, Ben

2008-01-01

An increasing number of corporations engage with users in co-innovation of products and services. But there are a number of competing perspectives on how best to integrate these understandings into existing corporate innovation development processes. This paper maps out three of the dominant appr...... the challenges such an approach sets to innovation management, and discuss research directions we see as fundamental to the development of the field of user-driven innovation. Udgivelsesdato: September......An increasing number of corporations engage with users in co-innovation of products and services. But there are a number of competing perspectives on how best to integrate these understandings into existing corporate innovation development processes. This paper maps out three of the dominant...... approaches, compares them in terms of goals, methods and basic philosophy, and shows how they may beneficially enrich one another. We will present an industrial innovation case that has been instrumental to the development of what we have termed ‘Participatory Innovation’. Based on this we will list...

National innovation system as a focus of state in-novation policy

Directory of Open Access Journals (Sweden)

Olexandr Fedirko

2007-02-01

Full Text Available The article offers a systematic review of tools and mechanisms utilised by developed countries (United States, Japan, EU to pursue their innovation policies, and classifies methods which support innovation and ways that help to strengthen the innovation capacity. It describes the evolution of research and development (R&D policy in other countries. The article examines arguments in support of a trend in the innovation policy which promotes the development of national innovation systems. It reviews the substance and components of the national innovation system. It also explores the trends of R&D cooperation. The article outlines the variety of domestic tools which regulate innovation in EU countries (framework programs, the European Research Area Initiative.

The Innovation Blaze-Method of Development Professional Thinking Designers in the Modern Higher Education

Science.gov (United States)

Alekseeva, Irina V.; Barsukova, Natalia I.; Pallotta, Valentina I.; Skovorodnikova, Nadia A.

2017-01-01

This article proved the urgency of the problem of development of professional thinking of students studying design in modern conditions of higher education. The authors substantiate for the need of an innovative Blaise-method development of professional design thinking of students in higher education. "Blaise-method" named by us in…

METHODICAL APPROACHES TO FORMING INNOVATIVE PROJECT AND ENTERPRISE MANAGEMENT ORGANIZATIONAL STRUCTURES

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A. O. Baklanov

2011-01-01

Full Text Available The following principles are discussed as methodical bases of the choice of innovative project and enterprise management organizational structures: hierarchism, bureaucratization, adhocratie, tent organization, lean business engineering, rational organization, amorphous organization, teaching organization. Conditions that complicate industrial and technological processes influence enterprise management process dynamics. The variety of existing types of organizational structures is determined by industrial, economic, psychological and social conditions.

Nonlinear dimensionality reduction methods for synthetic biology biobricks' visualization.

Science.gov (United States)

Yang, Jiaoyun; Wang, Haipeng; Ding, Huitong; An, Ning; Alterovitz, Gil

2017-01-19

Visualizing data by dimensionality reduction is an important strategy in Bioinformatics, which could help to discover hidden data properties and detect data quality issues, e.g. data noise, inappropriately labeled data, etc. As crowdsourcing-based synthetic biology databases face similar data quality issues, we propose to visualize biobricks to tackle them. However, existing dimensionality reduction methods could not be directly applied on biobricks datasets. Hereby, we use normalized edit distance to enhance dimensionality reduction methods, including Isomap and Laplacian Eigenmaps. By extracting biobricks from synthetic biology database Registry of Standard Biological Parts, six combinations of various types of biobricks are tested. The visualization graphs illustrate discriminated biobricks and inappropriately labeled biobricks. Clustering algorithm K-means is adopted to quantify the reduction results. The average clustering accuracy for Isomap and Laplacian Eigenmaps are 0.857 and 0.844, respectively. Besides, Laplacian Eigenmaps is 5 times faster than Isomap, and its visualization graph is more concentrated to discriminate biobricks. By combining normalized edit distance with Isomap and Laplacian Eigenmaps, synthetic biology biobircks are successfully visualized in two dimensional space. Various types of biobricks could be discriminated and inappropriately labeled biobricks could be determined, which could help to assess crowdsourcing-based synthetic biology databases' quality, and make biobricks selection.

Biomaterials innovation bundling technologies and life

CERN Document Server

Styhre, A

2014-01-01

Rapid advances in the life sciences means that there is now a far more detailed understanding of biological systems on the cellular, molecular and genetic levels. Sited at the intersection between the life sciences, the engineering sciences and the design sciences, innovations in the biomaterials industry are expected to garner increasing attention and play a key role in future development. This book examines the biomaterials innovations taking place in corporations and in academic research settings today.

Multi-hybrid instrumentations with smartphones and smartpads for innovative in-field and POC diagnostics

Science.gov (United States)

Hofmann, Dietrich; Dittrich, Paul-Gerald; Gärtner, Claudia; Klemm, Richard

2013-03-01

Aim of the paper is the orientation of research and development on a completely new approach to innovative in-field and point of care diagnostics in industry, biology and medicine. Central functional modules are smartphones and/or smart pads supplemented by additional hardware apps and software apps. Specific examples are given for numerous practical applications concerning optodigital instrumentations. The methodical classification distinguishes between different levels for combination of hardware apps (hwapps) and software apps (swapps) with smartphones and/or smartpads. These methods are fundamental enablers for the transformation from stationary conventional laboratory diagnostics into mobile innovative in-field and point of care diagnostics. The innovative approach opens so far untapped enormous markets due to the convenience, reliability and affordability of smartphone and/or smartpad instruments. A highly visible advantage of smartphones and/or smartpads is the huge number of their distribution, their worldwide connectivity via cloud services and the experienced capability of their users for practical operations.

The myths of innovation

National Research Council Canada - National Science Library

Berkun, Scott

2007-01-01

... . . . . . . . . . . . . . . . . . . . . . . 1 Chapter 2 We understand the history of innovation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 17 Chapter 3 There is a method for innovation...

Innovation indicators: a survey of innovative activities in the international food processed industry

Directory of Open Access Journals (Sweden)

Vinicius Cardoso de Barros Fornari

2015-02-01

Full Text Available This paper seeks to combine traditional methods of measuring intensity with other alternative indicators to examine the dispersion of innovation activities in different industries and countries. The hypothesis that underlies the study lies in the fact that in the Food Processed Industry (IAP the traditional methods are insufficient to detect the core of the innovation process. As method, we analyzed patent data extracted from the twenty-five largest food processed companies in the world and suggested different indicators developed from the Pesquisa de Inovação Tecnológica (PINTEC, 2010 – for Brazilian companies – and the Community Innovation Survey (CIS, 2009 – for European Union companies. The results allowed us to establish relationships in three dimensions: (i the complexity of the innovative effort of the IAP; (ii the efforts to innovation in different countries are distinct and; (iii there is heterogeneity in country performance.

Educational research methods for researching innovations in teaching, learning and assessment: The nursing lecturer as researcher.

Science.gov (United States)

Marks-Maran, Diane

2015-11-01

The author, who has had previous experience as a nurse researcher, has been engaged in helping nurse lecturers to undertake evaluation research studies into innovations in their teaching, learning and assessment methods. In order to undertake this work successfully, it was important to move from thinking like a nurse researcher to thinking like an educational researcher and developing the role of the nursing lecturer as researcher of their teaching. This article explores the difference between evaluation and evaluation research and argues for the need to use educational research methods when undertaking evaluation research into innovations in teaching, learning and assessment. A new model for educational evaluation research is presented together with two case examples of the model in use. The model has been tested on over 30 research studies into innovations in teaching, learning and assessment over the past 8 years. Copyright © 2015 Elsevier Ltd. All rights reserved.

The Methodical Bases of Assessment of Innovation Processes in the Sphere of Power Generation with Use of Opportunities of Cognitive Modeling

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Vikhlyaeva Nataliya V.

2017-10-01

Full Text Available The article presents the methodical bases of assessing the innovation processes of power generating companies with use of opportunities of cognitive modeling. It is specified that the method of cognitive modeling allows to remove contradictions concerning the interrelationship of the factors determining the innovation processes of the energy generating companies that usually arise when the results of research on the elements of the innovation system are being coordinated. Based on the arguments and practical examples, provided in the article, it was concluded that application of the method of cognitive modeling in the process of assessing the innovative capabilities of energy-generating companies is a sufficiently flexible and effective tool for supporting decision-making on strategic directions of their development.

Development of a Biological Science Quantitative Reasoning Exam (BioSQuaRE)

Science.gov (United States)

Stanhope, Liz; Ziegler, Laura; Haque, Tabassum; Le, Laura; Vinces, Marcelo; Davis, Gregory K.; Zieffler, Andrew; Brodfuehrer, Peter; Preest, Marion; Belitsky, Jason M.; Umbanhowar, Charles, Jr.; Overvoorde, Paul J.

2017-01-01

Multiple reports highlight the increasingly quantitative nature of biological research and the need to innovate means to ensure that students acquire quantitative skills. We present a tool to support such innovation. The Biological Science Quantitative Reasoning Exam (BioSQuaRE) is an assessment instrument designed to measure the quantitative…

Biological detector and method

Science.gov (United States)

Sillerud, Laurel; Alam, Todd M; McDowell, Andrew F

2013-02-26

A biological detector includes a conduit for receiving a fluid containing one or more magnetic nanoparticle-labeled, biological objects to be detected and one or more permanent magnets or electromagnet for establishing a low magnetic field in which the conduit is disposed. A microcoil is disposed proximate the conduit for energization at a frequency that permits detection by NMR spectroscopy of whether the one or more magnetically-labeled biological objects is/are present in the fluid.

Sustaining Innovative Success: A Case Study on Consumer-Centric Innovation in the ICT Industry

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Minkyung Choy

2016-09-01

Full Text Available The phenomenon of innovation growing rapidly and having a shorter lifespan is a structural change due to the development of ICT (Information and Communications Technology, diverse investment methods, and reduced pattern of innovation adoption. For ICT companies to survive and maintain their success in this ever-changing environment, they need to succeed in fulfilling both productivity and accuracy of innovation. To sustain their innovative success, ICT companies should consistently maintain the direction of innovation towards consumers. The present study analyzes various cases of ICT companies which succeeded or failed to maintain their prior innovative success, and suggests consumer-centric innovation as a solution. To create consumer-centric innovations, companies have to (1 predict the dynamically evolving demand of consumers and continuously transform; (2 proactively employ observation method and big data analysis to discover hidden demands; and (3 identify hassles such as wastes, inconveniences, and anxieties, and put effort in solving these hassles.

INNOVATIVE METHODS TO EVALUATE THE RELIABILITY OF INFORMATION CONSOLIDATED FINANCIAL STATEMENTS

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Irina P. Kurochkina

2014-01-01

Full Text Available The article explores the possibility of using foreign innovative methods to assess the reliabilityof information consolidated fi nancial statements of Russian companies. Recommendations aremade under their adaptation and applicationinto commercial organizations. Banish methodindicators are implemented in one of the world’s largest vertically integrated steel and miningcompanies. Audit firms are proposed to usemethods of assessing the reliability of information in the practical application of ISA.

Innovative Research Methods for Rethinking Gender in CSPs

DEFF Research Database (Denmark)

McCarthy, Lauren

2016-01-01

Gender and women’s empowerment has become a big issue within CSPs in recent years. (See pages 58-61). Yet designing research projects that have proven impact on improving the lives of women in supply chains can be challenging, especially in CSPs where under - standings of ‘gender’ and ‘equality’ ......’ can differ culturally. This article therefore explores innovative research methods suitable to get a clearer view on gender issues.......Gender and women’s empowerment has become a big issue within CSPs in recent years. (See pages 58-61). Yet designing research projects that have proven impact on improving the lives of women in supply chains can be challenging, especially in CSPs where under - standings of ‘gender’ and ‘equality...

Synthetic Methods and Exploring Biological Potential of Various Substituted Quinoxalin-2-one Derivatives

OpenAIRE

Mohammad Asif

2016-01-01

Substituted quinoxaline have considerable interest in chemistry, biology and pharmacology. Quinoxaline derivatives are capable with variety of biological activities and possess different biological activities, of which the most potent are anti-microbial, analgesic and anti-inflammatory activities. It facilitated the researchers to develop various methods for their synthesis and their applications. In this review represented different methods of synthesis, reactivity and various biological act...

Progeny Clustering: A Method to Identify Biological Phenotypes

Science.gov (United States)

Hu, Chenyue W.; Kornblau, Steven M.; Slater, John H.; Qutub, Amina A.

2015-01-01

Estimating the optimal number of clusters is a major challenge in applying cluster analysis to any type of dataset, especially to biomedical datasets, which are high-dimensional and complex. Here, we introduce an improved method, Progeny Clustering, which is stability-based and exceptionally efficient in computing, to find the ideal number of clusters. The algorithm employs a novel Progeny Sampling method to reconstruct cluster identity, a co-occurrence probability matrix to assess the clustering stability, and a set of reference datasets to overcome inherent biases in the algorithm and data space. Our method was shown successful and robust when applied to two synthetic datasets (datasets of two-dimensions and ten-dimensions containing eight dimensions of pure noise), two standard biological datasets (the Iris dataset and Rat CNS dataset) and two biological datasets (a cell phenotype dataset and an acute myeloid leukemia (AML) reverse phase protein array (RPPA) dataset). Progeny Clustering outperformed some popular clustering evaluation methods in the ten-dimensional synthetic dataset as well as in the cell phenotype dataset, and it was the only method that successfully discovered clinically meaningful patient groupings in the AML RPPA dataset. PMID:26267476

Informal Innovation

DEFF Research Database (Denmark)

Hartmann, Mia Rosa Koss; Hartmann, Rasmus Koss

Informal innovation, defined as the development and putting-into-use of novel solutions by non-R&D employees without prior formal approval from or subsequent revealing to superiors, has been recurrently observed in organizational research. But even as it is increasingly recognized that R&D is not......Informal innovation, defined as the development and putting-into-use of novel solutions by non-R&D employees without prior formal approval from or subsequent revealing to superiors, has been recurrently observed in organizational research. But even as it is increasingly recognized that R......&D is not the only plausible source of innovation inside organizations, informal innovation has yet to be systematically explored or theorized. We propose a theory of informal innovation based on analyses of prior literature and mixed-method, multi-site studies of innovation at the working level of two extreme......-case organizations. We propose that informal innovation occurs as 1) employees personally experience problems that they believe are not recognized or prioritized by superiors; 2) some employees are able to develop solutions, essentially at no cost; 3) innovators face no benefits from revealing to superiors, but can...

Evaluation of the Teaching Methods Used in Secondary School Biology Lessons

Directory of Open Access Journals (Sweden)

Porozovs Juris

2015-06-01

Full Text Available The teacher’s skills in conducting the lesson and choice of teaching methods play an essential role in creating students’ interest in biology. The aim of the research was to study the opinion of secondary school students and biology teachers regarding the most successful teaching methods used in biology lessons and viable options to make biology lessons more interesting. The research comprised polling students and biology teachers from several schools, namely: 2 secondary schools in Jelgava, 2 in Riga and 1 in Vecumnieki. The responses revealed that 58% of students find biology lessons interesting. 56% of students indicated that their ability to focus attention during biology lessons depends on the task presented to them. Most of all they prefer watching the teacher’s presentations, listening to their teacher telling about the actual topic as well as performing laboratory work and group-work. Many students like participating in discussions, whereas a far smaller number would do various exercises, individual tasks, fill out worksheets or complete projects. Least of all students wish to work with the textbook. The methods most frequently applied by teachers are as follows: lecture, explanation, demonstration, and discussion. Teachers believe that their students prefer laboratory work and discussions as well as listening to their teacher and watching presentations or films. They also indicate at the necessity to link theory with practice and to involve information technologies. While teaching their subject biology teachers try to establish relationship between theory and real life in order to develop their students’ interest in natural processes.

Using the Scientific Method to Motivate Biology Students to Study Precalculus

Science.gov (United States)

Fulton, James P.; Sabatino, Linda

2008-01-01

During the last two years we have developed a precalculus course customized around biology by using the scientific method as a framework to engage and motivate biology students. Historically, the precalculus and calculus courses required for the Suffolk County Community College biology curriculum were designed using examples from the physical…

Adding to The Innovation Taxonomy

Directory of Open Access Journals (Sweden)

Bengt-Arne Vedin

2014-02-01

Full Text Available Innovation might be described in a number of categories: radical, disruptive, incremental, or, by type, product, process, and service innovation. Social and conceptual innovations are decidedly more abstract. In recent years, open and also frugal innovation have been defined. This essay suggests and contemplates four additional concepts. Mesovation is in between radical and incremental innovation. Exovation stands for systematic ways to reduce barriers to innovation. Metovations are novel methods or systems affecting conditions for innovation. Lastly, ynnovation would be cultural innovation.

New ways of organizing innovation work

DEFF Research Database (Denmark)

Grex, Sara; Møller, Niels

2006-01-01

There is an intensified focus in innovation and companies ability to create innovation. In many companies these activities are organized by projects, but studies show this innovation is stifled in this structure. In this paper we argue that there is a need for developing alternative ways of organ......There is an intensified focus in innovation and companies ability to create innovation. In many companies these activities are organized by projects, but studies show this innovation is stifled in this structure. In this paper we argue that there is a need for developing alternative ways...... of organizing innovative activities in project-based settings. We propose the Contextual Design method as a way of both studying innovation work processes and an approach to redesign the innovation work organization. We find that the method can contribute to a better understanding of the innovation work...

Biologically Inspired Technology Using Electroactive Polymers (EAP)

Science.gov (United States)

Bar-Cohen, Yoseph

2006-01-01

Evolution allowed nature to introduce highly effective biological mechanisms that are incredible inspiration for innovation. Humans have always made efforts to imitate nature's inventions and we are increasingly making advances that it becomes significantly easier to imitate, copy, and adapt biological methods, processes and systems. This brought us to the ability to create technology that is far beyond the simple mimicking of nature. Having better tools to understand and to implement nature's principles we are now equipped like never before to be inspired by nature and to employ our tools in far superior ways. Effectively, by bio-inspiration we can have a better view and value of nature capability while studying its models to learn what can be extracted, copied or adapted. Using electroactive polymers (EAP) as artificial muscles is adding an important element to the development of biologically inspired technologies.

Innovation ability and innovation spirit in photoelectric comprehensive experiment teaching

Science.gov (United States)

Wang, Dexing; Zhang, Yang; Wang, Xiaofeng; Zhang, Xiaojun; Zhang, Tao; Sun, Peng

2017-08-01

The traditional experimental teaching methods have some shortcomings in the training the student innovation ability. In order to improve the student practical ability in the photoelectric technology, in this paper new experimental teaching modes are tried and reformed for cultivating the innovative ability of students in the linear CCD experiment. The photoelectric experiment systems are independently designed and completed by students. Compared with the traditional experimental teaching methods, this new methods have a great role in the development of the ability of creative thinking.

The Impact of Organismal Innovation on Functional and Ecological Diversification.

Science.gov (United States)

Wainwright, Peter C; Price, Samantha A

2016-09-01

Innovations in organismal functional morphology are thought to be a major force in shaping evolutionary patterns, with the potential to drive adaptive radiation and influence the evolutionary prospects for lineages. But the evolutionary consequences of innovation are diverse and usually do not result in adaptive radiation. What factors shape the macroevolutionary impact of innovations? We assert that little is known in general about the macroevolutionary outcomes associated with functional innovations and we discuss a framework for studying biological innovations in an evolutionary context. Innovations are novel functional mechanisms that enhance organismal performance. The ubiquity of trade-offs in functional systems means that enhanced performance on one axis often occurs at the expense of performance on another axis, such that many innovations result in an exchange of performance capabilities, rather than an expansion. Innovations may open up new resources for exploitation but their consequences for functional and ecological diversification depend heavily on the adaptive landscape around these novel resources. As an example of a broader program that we imagine, we survey five feeding innovations in labrid fishes, an exceptionally successful and ecologically diverse group of reef fishes, and explore their impact on the rate of evolution of jaw functional morphology. All of the innovations provide performance enhancements and result in changes in patterns of resource use, but most are not associated with subsequent functional diversification or substantial ecological diversification. Because selection acts on a specific performance enhancement and not on the evolutionary potential of an innovation, the enhancement of diversity may be highly serendipitous. The macroevolutionary potential of innovations depends critically on the interaction between the performance enhancement and the ecological opportunity that is exposed. © The Author 2016. Published by Oxford

Innovation of floating time domain electromagnetic method in the case of environmental geophysics

Science.gov (United States)

Nurjanah, Siti; Widodo

2017-07-01

Geophysics has some methods that can be used to reveal the subsurface structure of the earth. The physical features obtained from the acquisition then analyzed and interpreted, so that it can be a great lead to interpret the physical contents, determine its position and its distribution. Geophysical methods also can be used to help the environment contamination survey which is referred to environmental geophysics. There are many sources of pollution that can harm the nature, for example, the source in the form of solid waste, liquid waste containing heavy metals, or radioactive, and etc. As time passes, these sources might settle in any sedimentary area and become sediments. Time Domain Electromagnetic (TDEM) is a trustworthy method to detect the presence of conductive anomaly due to sediment accumulation. Innovation of floating TDEM created to maximize the potential of the method, so that it can be used in aquatic environments. The configuration of TDEM modified using pipes and tires during the process of measurements. We conducted numerical simulation using Marquardt and Occam Algorithms towards synthetic model to ensure the capability of the proposed design. The development of this innovation is expected to be very useful to repair the natural conditions, especially in the water.

Laser-induced micro-thermography - an innovative method of nondestructive testing of coatings. Laserinduzierte Mikrothermographie - ein innovatives ZfP-Verfahren zur Pruefung von Beschichtungen

Energy Technology Data Exchange (ETDEWEB)

Radtke, U; Crostack, H A; Peppler, P; Winschuh, E

1992-01-01

The described, innovative NDT method of the laser-induced thermowave analysis, also called laser-induced microthermography, permits the 3D imaging of thermal characteristics with high axial and lateral resolution. The results show that the method is suitable for the quality control of coatings and yields information on thickness, thermal homogeneity and adhesion as well as valuable additional information, as compared to conventional metallography. (orig.)

Measuring Consumer Innovativeness: Identifying Innovators among Consumers of Modern Technologies

Directory of Open Access Journals (Sweden)

Jana Filová

2015-12-01

Full Text Available The methods currently used in innovation marketing research are focused on the late phases of the innovation process and are usually methodologically complex. This limits their practical impact. The presented work aims to create a simple self-report scale applicable in the initial and late phases of the innovation process, highly modular and suitable for a wide range of research. The main battery of questions was inspired by the adopter categorization by Rogers. The questions determine both (1 general characteristics of innovation adopters and (2 their relationship to a specific innovation. The scale was tested during robust longitudinal online research, thematically focused on users of modern technologies. A representative sample of 4,000 Internet users in the Czech Republic took part in the survey from 2013 to 2015. The result is a new self-report scale measuring consumer innovativeness applicable for prototyping, strategic decisions and effective communication of innovations to consumers.

Effectiveness of Various Innovative Learning Methods in Health Science Classrooms: A Meta-Analysis

Science.gov (United States)

Kalaian, Sema A.; Kasim, Rafa M.

2017-01-01

This study reports the results of a meta-analysis of the available literature on the effectiveness of various forms of innovative small-group learning methods on student achievement in undergraduate college health science classrooms. The results of the analysis revealed that most of the primary studies supported the effectiveness of the…

Synergetic Basis of Innovation Marketing

OpenAIRE

Melnyk, L; Dehtyarova, I

2012-01-01

Issues of synergetic effects of innovation marketing are considered in the article. It shows sources of synergetic effects of innovation marketing, types of synergism, synergetic effects of marketing innovations, as well as evaluation methods.

Three-Dimensional Printing of Human Skeletal Muscle Cells: An Interdisciplinary Approach for Studying Biological Systems

Science.gov (United States)

Bagley, James R.; Galpin, Andrew J.

2015-01-01

Interdisciplinary exploration is vital to education in the 21st century. This manuscript outlines an innovative laboratory-based teaching method that combines elements of biochemistry/molecular biology, kinesiology/health science, computer science, and manufacturing engineering to give students the ability to better conceptualize complex…

Innovation of fission gas release and thermal conductivity measurement methods

International Nuclear Information System (INIS)

Van der Meer, K.; Soboler, V.

1998-01-01

This presentation described two innovative measurement methods being currently developed at SCK-CEN in order to support the modeling of fuel performance. The first one is an acoustic method to measure the fission gas release in a fuel rod in a non destructive way. The total rod pressure is determined by generating a heat pulse causing a pressure wave that propagates through the gas to an ultrasound transducer. The final pulse width being proportional to the pressure, the latter can thus be determined. The measurement of the acoustic resonance frequency at fixed temperatures enables the distinction between different gas components. The second method is a non-stationary technique to investigate the thermal properties of the fuel rod, like thermal conductivity, diffusivity and heat capacity. These properties are derived from the amplitude and the phase shift of the fuel centre temperature response induced by a periodic temperature variation. These methods did not reveal any physical limitations for the practical applicability. Furthermore, they are rather simple. Preliminary investigations have proven both methods to be more accurate than techniques usually utilized. (author)

Innovative Directions of the Higher Education of Ukraine

Directory of Open Access Journals (Sweden)

Klyap Marianna

2016-11-01

Full Text Available The article clarifies the concept of “innovation”, including “educational innovation”, examines some innovative teaching methods in universities. The main approaches of implementation innovations in modern higher education of Ukraine are analysed. It also defines the differences between traditional and innovative teaching, discovers different variants of the classification of innovative teaching methods and formulates basic approaches to the selection of innovative didactic purpose in accordance with the classes, the advantages and disadvantages of the use of certain methods. It tightly describes actual interpretation of innovative study methods in the Ukrainian higher educational institutions, as well as the realization of the innovative aspects in the separate Ukrainian universities. The importance of innovation in the learning process of entering higher education of Ukraine into the European educational space is also being highlighted.

Research with School Students: Four Innovative Methods Used to Explore Effective Teaching

Directory of Open Access Journals (Sweden)

Jessica Faye Heal

2015-03-01

Full Text Available This article outlines four research methods we’ve employed to enhance how students from low-income backgrounds engage in research exploring effective teaching. It firstly outlines the need to be innovative, drawing Article 12 of the United Nations Convention on the Rights of the Child, and then moves on to explain two methods that scaffold a semi-structured interview, one child-led classroom tour and finally a creative ‘draw and tell’ approach. It argues that these methods are successful because they disrupt the researcher-participant power imbalance using the following techniques: Familiarity to the student, empowering the student to be an expert, and giving the student choice.

X-ray structure analyses of biological molecules and particles in Japan. A brief history and future prospect

International Nuclear Information System (INIS)

Nakasako, Masayoshi; Yamamoto, Masaki

2015-01-01

In Japan, X-ray structure analyses of molecules and particles from biology started in the 1970s. The structure analysis methods have been developed through the innovation of various techniques in advance, and have contributed for understanding the elementary and microscopic processes in life. Here we summarize briefly the history of X-ray structure analyses for structural biology in Japan and think about the prospect. (author)

Innovative pretreatment strategies for biogas production.

Science.gov (United States)

Patinvoh, Regina J; Osadolor, Osagie A; Chandolias, Konstantinos; Sárvári Horváth, Ilona; Taherzadeh, Mohammad J

2017-01-01

Biogas or biomethane is traditionally produced via anaerobic digestion, or recently by thermochemical or a combination of thermochemical and biological processes via syngas (CO and H 2 ) fermentation. However, many of the feedstocks have recalcitrant structure and are difficult to digest (e.g., lignocelluloses or keratins), or they have toxic compounds (such as fruit flavors or high ammonia content), or not digestible at all (e.g., plastics). To overcome these challenges, innovative strategies for enhanced and economically favorable biogas production were proposed in this review. The strategies considered are commonly known physical pretreatment, rapid decompression, autohydrolysis, acid- or alkali pretreatments, solvents (e.g. for lignin or cellulose) pretreatments or leaching, supercritical, oxidative or biological pretreatments, as well as combined gasification and fermentation, integrated biogas production and pretreatment, innovative biogas digester design, co-digestion, and bio-augmentation. Copyright © 2016 Elsevier Ltd. All rights reserved.

Innovation quality in knowledge cities

DEFF Research Database (Denmark)

Makkonen, Teemu; Inkinen, Tommi

2014-01-01

Innovation awards have for long attracted policy makers as a method for innovation promotion. Still, academic research on innovation awards has thus far received little attention. In particular, empirical studies on the motives to enter award competitions and the realized impacts of winning an in...... for innovation promotion, alongside innovation inducement policies including tax reductions and direct funding, as they produce significant positive effects for the award winning companies, and an additional indicator of innovation quality in the context of knowledge cities....

Measurement Frontiers in Molecular Biology

Science.gov (United States)

Laderman, Stephen

2009-03-01

Developments of molecular measurements and manipulations have long enabled forefront research in evolution, genetics, biological development and its dysfunction, and the impact of external factors on the behavior of cells. Measurement remains at the heart of exciting and challenging basic and applied problems in molecular and cell biology. Methods to precisely determine the identity and abundance of particular molecules amongst a complex mixture of similar and dissimilar types require the successful design and integration of multiple steps involving biochemical manipulations, separations, physical probing, and data processing. Accordingly, today's most powerful methods for characterizing life at the molecular level depend on coordinated advances in applied physics, biochemistry, chemistry, computer science, and engineering. This is well illustrated by recent approaches to the measurement of DNA, RNA, proteins, and intact cells. Such successes underlie well founded visions of how molecular biology can further assist in answering compelling scientific questions and in enabling the development of remarkable advances in human health. These visions, in turn, are motivating the interdisciplinary creation of even more comprehensive measurements. As a further and closely related consequence, they are motivating innovations in the conceptual and practical approaches to organizing and visualizing large, complex sets of interrelated experimental results and distilling from those data compelling, informative conclusions.

Co-Designing and Co-Teaching Graduate Qualitative Methods: An Innovative Ethnographic Workshop Model

Science.gov (United States)

Cordner, Alissa; Klein, Peter T.; Baiocchi, Gianpaolo

2012-01-01

This article describes an innovative collaboration between graduate students and a faculty member to co-design and co-teach a graduate-level workshop-style qualitative methods course. The goal of co-designing and co-teaching the course was to involve advanced graduate students in all aspects of designing a syllabus and leading class discussions in…

Responsible innovation

CERN Document Server

De Woot, Philippe

2015-01-01

Economic development is rooted in disruption, not in equilibrium. And a powerful engine of economic development is innovation; but is this innovation always for the common good? The dark side of the extraordinary dynamism of innovation lies precisely in its destructive power. If simply left to market forces, it could lead to social chaos and great human suffering. To face the challenges of our time, we must create the proper climate and culture to develop strong entrepreneurial drive. But, more than ever, we must give this entrepreneurial drive its ethical and societal dimensions. Responsible innovation means a more voluntary orientation towards the great problems of the 21st century, e.g. depletion of the planet's resources, rising inequality, and new scientific developments potentially threatening freedom, democracy and human integrity. We need to transform our ceaseless creativity into real progress for humankind. In this respect, the rapid development of social innovation opens the door for new methods an...

Assessment of refinery effluents and receiving waters using biologically-based effect methods

International Nuclear Information System (INIS)

2012-01-01

Within the EU it is apparent that the regulatory focus on the use of biologically-based effects methods in the assessment of refinery effluents and receiving waters has increased in the past decade. This has been reflected in a recent refinery survey which revealed an increased use of such methods for assessing the quality of refinery effluents and their receiving waters. This report provides an overview of recent techniques used for this purpose. Several case studies provided by CONCAWE member companies describe the application of biological methods to effluent discharge assessment and surface water monitoring. The case studies show that when biological methods are applied to refinery effluents and receiving waters they raise different questions compared with those obtained using physical and chemical methods. Although direct measurement of the toxicity of effluent and receiving to aquatic organisms is the most cited technique, more recent efforts include tests that also address the persistence of effluent toxicity once discharged into the receiving water. Similarly, ecological monitoring of receiving waters can identify effects of effluent inputs arising from species interactions and other secondary effects that would not always be apparent from the results of biological tests conducted on single aquatic organisms. In light of recent and proposed regulatory developments the objectives of this report are therefore to: Discuss the application of biologically-based effects methods (including ecological monitoring) to refinery discharges and receiving waters; Assess the implications of such methods for future regulation of refinery discharges; and Provide guidance on good practice that can be used by refineries and the downstream oil industry to carry out and interpret data obtained using biologically-based effects methods. While the emphasis is on the toxic effects of effluents, other properties will also be covered because of their interdependency in determining

Assessment of refinery effluents and receiving waters using biologically-based effect methods

Energy Technology Data Exchange (ETDEWEB)

NONE

2012-01-15

Within the EU it is apparent that the regulatory focus on the use of biologically-based effects methods in the assessment of refinery effluents and receiving waters has increased in the past decade. This has been reflected in a recent refinery survey which revealed an increased use of such methods for assessing the quality of refinery effluents and their receiving waters. This report provides an overview of recent techniques used for this purpose. Several case studies provided by CONCAWE member companies describe the application of biological methods to effluent discharge assessment and surface water monitoring. The case studies show that when biological methods are applied to refinery effluents and receiving waters they raise different questions compared with those obtained using physical and chemical methods. Although direct measurement of the toxicity of effluent and receiving to aquatic organisms is the most cited technique, more recent efforts include tests that also address the persistence of effluent toxicity once discharged into the receiving water. Similarly, ecological monitoring of receiving waters can identify effects of effluent inputs arising from species interactions and other secondary effects that would not always be apparent from the results of biological tests conducted on single aquatic organisms. In light of recent and proposed regulatory developments the objectives of this report are therefore to: Discuss the application of biologically-based effects methods (including ecological monitoring) to refinery discharges and receiving waters; Assess the implications of such methods for future regulation of refinery discharges; and Provide guidance on good practice that can be used by refineries and the downstream oil industry to carry out and interpret data obtained using biologically-based effects methods. While the emphasis is on the toxic effects of effluents, other properties will also be covered because of their interdependency in determining

SINGLE MOLECULE APPROACHES TO BIOLOGY, 2010 GORDON RESEARCH CONFERENCE, JUNE 27-JULY 2, 2010, ITALY

Energy Technology Data Exchange (ETDEWEB)

Professor William Moerner

2010-07-09

The 2010 Gordon Conference on Single-Molecule Approaches to Biology focuses on cutting-edge research in single-molecule science. Tremendous technical developments have made it possible to detect, identify, track, and manipulate single biomolecules in an ambient environment or even in a live cell. Single-molecule approaches have changed the way many biological problems are addressed, and new knowledge derived from these approaches continues to emerge. The ability of single-molecule approaches to avoid ensemble averaging and to capture transient intermediates and heterogeneous behavior renders them particularly powerful in elucidating mechanisms of biomolecular machines: what they do, how they work individually, how they work together, and finally, how they work inside live cells. The burgeoning use of single-molecule methods to elucidate biological problems is a highly multidisciplinary pursuit, involving both force- and fluorescence-based methods, the most up-to-date advances in microscopy, innovative biological and chemical approaches, and nanotechnology tools. This conference seeks to bring together top experts in molecular and cell biology with innovators in the measurement and manipulation of single molecules, and will provide opportunities for junior scientists and graduate students to present their work in poster format and to exchange ideas with leaders in the field. A number of excellent poster presenters will be selected for short oral talks. Topics as diverse as single-molecule sequencing, DNA/RNA/protein interactions, folding machines, cellular biophysics, synthetic biology and bioengineering, force spectroscopy, new method developments, superresolution imaging in cells, and novel probes for single-molecule imaging will be on the program. Additionally, the collegial atmosphere of this Conference, with programmed discussion sessions as well as opportunities for informal gatherings in the afternoons and evenings in the beauty of the Il Ciocco site in

Innovation and Safety. A prestudy; Innovation och saekerhet. En foerstudie

Energy Technology Data Exchange (ETDEWEB)

Rollenhagen, Carl; Hansson, Sven Ove; Hortberg, Johan; Jakobsson, Fredrik; Zhau, Victoria Jing; Mojeri, Sara

2010-04-15

The project summarized in this report was initiated to explore relations between innovation and safety. The first two sections of the report discuss some previously conducted research and give a general background to the subject. It is concluded that safety research and innovation research, by and large, has developed as separate academic disciplines. The concepts of 'innovative safety culture' and 'safe innovation cultures' are suggested as two concepts that can be used to integrate research: innovative safety cultures depart from safety culture research but attempts to introduce an innovative dimension with the aim to create adaptive and innovative safety cultures that efficiently can handle risks arising from existing innovations. Safe innovation cultures have focus on innovation itself, but with the ambition to introduce concepts and methods from safety research in the innovative processes. Three subprojects conducted in the context of the present research are summarized. The first project examines how an existing organization (e.g. SKB - Swedish Nuclear Fuel and Waste Management) attempts to integrate both innovative activities and operative activities in the same organisation. Interviews with key personnel explored different views about how innovative and safety work coexists in the organisation. The second project focuses on how major retrofit projects of a nuclear power plant is managed in parallel to operative activities (e.g. operating the plant on an everyday basis). By means of an innovative technique (e.g. system groups) seminars were held to suggest improvements in the technical change process. The third project conducted a risk analysis of a major organisational change (e.g. control centres for energy distribution). Experiences from the three projects are finally discussed in terms of similarities and differences associated with the cultures for innovation and safety. Suggestions for further research are made

Deliberation as Communication Instruction: A Study of a Climate Change Deliberation in an Introductory Biology Course

Science.gov (United States)

Drury, Sara A. Mehltretter

2015-01-01

The author argues that deliberation is an innovative method for teaching communication skills, particularly group communication, in the undergraduate science, technology, engineering, and math (STEM) curriculum. A case study using a deliberation activity on global climate change in an introductory biology course demonstrates how deliberative…

INNOVATIVE METHODS OF TEACHING HISTORY AT MODERN UNIVERSITIES

Directory of Open Access Journals (Sweden)

A. Yu. Suslov

2017-01-01

Full Text Available Introduction. As a discipline, History holds a specific place among disciplines of a humanitarian cycle of educational programs of higher education institutions regardless of university specialities. History plays an important role in the course of formation of a citizen and development of critical thinking of a personality as an element of a common culture. However, new federal standards require a drastic reduction of the classroom hours for studying a History course by students of non-humanitarian specialties, and, at the same time, enhancement of the contents of a discipline (its reorientation from History of Russia towards World History. Therefore, History programmes and courses demand up-to-date approaches, methods and didactic means to provide formation of holistic worldview of future experts.The aim of the article is to consider the features of innovative methods application in teaching history in high school taking into consideration modernization processes.Methodology and research methods. The research undertaken is based on activity and competence-based approaches. The methods of analysis and synthesis of the academic literature on the research topic were used; the methods of reflection and generalization of teaching activities of the Department of Humanitarian Disciplines of theKazanNationalResearchTechnologicalUniversity were applied as well.Results and scientific novelty. A modern view on historical education has been proposed as means of students’ systems thinking formation, designing the ideas about the world historical process among students, the mission ofRussia in this process, and evolution ofRussia as a part of the modern civilization. It is stated that History university course is designed not only to give the students strong subject knowledge, but also to create axiological orientations and abilities on the basis of the analysis of historical collisions, objective and subjective factors of society development. Moreover

Finland: Innovation Policy Tools under National Innovation System Crisis

Directory of Open Access Journals (Sweden)

Daria A. Vorobeva

2017-01-01

Full Text Available Purpose: the for a long time Finland’s national innovation system (NIS had been being one of the most successful and effective in the world. But some years ago the situation changed: Finland’s NIS run into system crisis. And today Finnish government tries to work out anticrisis innovation policy. So the purpose of this article is to show up the innovation policy instruments which are able put an end to the crisis and to determine conditions of their successful use. Methods: the article is based on the national innovation systems concept and government policy-mix aimed at the NIS development. Results: the authors show up how Finnish government looks for optimal policy-mix to overcome the crisis, demonstrate in details complementary components of the relevant innovation policy, describe conditions for their success and effectiveness to consider whether they are useful in other countries. Conclusions and Relevance: to overcome the NIS crisis the Finnish government uses such instruments as strategic programs of socio-economic development with targets which can’t be achieved without adequate high technology and innovative development complemented by incentives to make business innovate actively. The conditions of such policy success are: 1 such feature of Finnish society as all stakeholders of economic development consensus on one issue: the main factor of development are innovations; 2 anticrisis stage of Finnish innovative policy is based previously accumulated knowledge and know-how. 

The model and the planning method of volume and variety assessment of innovative products in an industrial enterprise

Science.gov (United States)

Anisimov, V. G.; Anisimov, E. G.; Saurenko, T. N.; Sonkin, M. A.

2017-01-01

In the long term, the innovative development strategy efficiency is considered as the most crucial condition for assurance of economic system competitiveness in market conditions. It determines the problem relevance of such justification strategies with regard to specific systems features and conditions of their operation. The problem solution for industrial enterprises can be based on mathematical models of supporting the decision-making on the elements of the innovative manufacturing program. An optimization model and the planning method of innovative products volume and variety are suggested. The feature of the suggested model lies in the nonlinear nature of the objective function. It allows taking into consideration the law of diminishing marginal utility. The suggested method of optimization takes into account the system features and enables the effective implementation of manufacturing capabilities in modern conditions of production organization and sales in terms of market saturation.

2010 Diffraction Methods in Structural Biology

Energy Technology Data Exchange (ETDEWEB)

Dr. Ana Gonzalez

2011-03-10

Advances in basic methodologies have played a major role in the dramatic progress in macromolecular crystallography over the past decade, both in terms of overall productivity and in the increasing complexity of the systems being successfully tackled. The 2010 Gordon Research Conference on Diffraction Methods in Structural Biology will, as in the past, focus on the most recent developments in methodology, covering all aspects of the process from crystallization to model building and refinement, complemented by examples of structural highlights and complementary methods. Extensive discussion will be encouraged and it is hoped that all attendees will participate by giving oral or poster presentations, the latter using the excellent poster display area available at Bates College. The relatively small size and informal atmosphere of the meeting provides an excellent opportunity for all participants, especially younger scientists, to meet and exchange ideas with leading methods developers.

Teaching Biology for a Sustainable Future

Science.gov (United States)

Musante, Susan

2011-01-01

Students at Calvin College in Grand Rapids, Michigan, can now take an innovative biology course in which an integrated, interdisciplinary, problem-based approach is used--one that the scientific community itself is promoting. The first course in a four-semester sequence, Biology 123--The Living World: Concepts and Connections--explores real-world…

Bureaucracy and Innovation Revisited

DEFF Research Database (Denmark)

Hartmann, Mia Koss; Koss Hartmann, Rasmus

, but by problematizing the relationship directly. Inspired by prior ethnographic studies of coercive bureaucracies and theories of secrecy and hiding behavior, we propose that coercive bureaucracies do not necessarily impede innovation, but rather create the appearance of doing so. Coercive bureaucracies create......, supplemented by innovation histories, surveys and expert evaluations. This argument implies that future research examines more deeply the organizational processes and practices by which innovation might occur even in coercive bureaucracies. Further, it encourages innovation research methods that rely less...

Innovative method by design-around concepts with integrating the algorithm for inventive problem solving

International Nuclear Information System (INIS)

Chen, Wang Chih; Chen Jahau Lewis

2014-01-01

The work proposes a new design tool that integrates design-around concepts with the algorithm for inventive problem solving (Russian acronym: ARIZ). ARIZ includes a complete procedure for analyzing problems and related resource, resolving conflicts and generating solutions. The combination of ARIZ and design-around concepts and understanding identified principles that govern patent infringements can prevent patent infringements whenever designers innovate, greatly reducing the cost and time associated with the product design stage. The presented tool is developed from an engineering perspective rather than a legal perspective, and so can help designers easily to prevent patent infringements and succeed in innovating by designing around. An example is used to demonstrate the proposed method.

Innovative use of technologies and methods to redesign care: the problem of care transitions.

Science.gov (United States)

Richman, Mark; Sklaroff, Laura Myerchin; Hoang, Khathy; Wasson, Elijah; Gross-Schulman, Sandra

2014-01-01

Organizations are redesigning models of care in today's rapidly changing health care environment. Using proven innovation techniques maximizes likelihood of effective change. Our safety-net hospital aims to reduce high emergency department visit, admission, and readmission rates, key components to health care cost control. Twenty-five clinical stakeholders participated in mixed-methods innovation exercises to understand stakeholders, frame problems, and explore solutions. We identified existing barriers and means to improve post-emergency department/post-inpatient discharge care coordination/communication among patient-centered medical home care team members, including patients. Physicians and staff preferred automated e-mail notifications, including patient identifiers, medical home/primary care provider information, and relevant clinical documentation, to improve communication efficiency/efficacy.

Diagnosing risks in product-innovation projects

NARCIS (Netherlands)

Halman, Johannes I.M.; Keizer, J.A.

A new method of diagnosing risks in product-innovation projects is introduced in the paper. The method is an improvement on existing risk methods used on product-innovation projects, such as potential problem analysis and failure mode and effects analysis. Technological, organizational and

Diagnosing risks in product-innovation projects

NARCIS (Netherlands)

Halman, J.I.M.; Keizer, J.A.

1994-01-01

A new method of diagnosing risks in product-innovation projects is introduced in the paper. The method is an improvement on existing risk methods used on product-innovation projects, such as potential problem analysis and failure mode and effects analysis. Technological, organizational and

Essence: Facilitating Software Innovation

DEFF Research Database (Denmark)

Aaen, Ivan

2008-01-01

  This paper suggests ways to facilitate creativity and innovation in software development. The paper applies four perspectives – Product, Project, Process, and People –to identify an outlook for software innovation. The paper then describes a new facility–Software Innovation Research Lab (SIRL......) – and a new method concept for software innovation – Essence – based on views, modes, and team roles. Finally, the paper reports from an early experiment using SIRL and Essence and identifies further research....

Synergistic Synthetic Biology: Units in Concert

Science.gov (United States)

Trosset, Jean-Yves; Carbonell, Pablo

2013-01-01

Synthetic biology aims at translating the methods and strategies from engineering into biology in order to streamline the design and construction of biological devices through standardized parts. Modular synthetic biology devices are designed by means of an adequate elimination of cross-talk that makes circuits orthogonal and specific. To that end, synthetic constructs need to be adequately optimized through in silico modeling by choosing the right complement of genetic parts and by experimental tuning through directed evolution and craftsmanship. In this review, we consider an additional and complementary tool available to the synthetic biologist for innovative design and successful construction of desired circuit functionalities: biological synergies. Synergy is a prevalent emergent property in biological systems that arises from the concerted action of multiple factors producing an amplification or cancelation effect compared with individual actions alone. Synergies appear in domains as diverse as those involved in chemical and protein activity, polypharmacology, and metabolic pathway complementarity. In conventional synthetic biology designs, synergistic cross-talk between parts and modules is generally attenuated in order to verify their orthogonality. Synergistic interactions, however, can induce emergent behavior that might prove useful for synthetic biology applications, like in functional circuit design, multi-drug treatment, or in sensing and delivery devices. Synergistic design principles are therefore complementary to those coming from orthogonal design and may provide added value to synthetic biology applications. The appropriate modeling, characterization, and design of synergies between biological parts and units will allow the discovery of yet unforeseeable, novel synthetic biology applications. PMID:25022769

Synergistic Synthetic Biology: Units in Concert

International Nuclear Information System (INIS)

Trosset, Jean-Yves; Carbonell, Pablo

2013-01-01

Synthetic biology aims at translating the methods and strategies from engineering into biology in order to streamline the design and construction of biological devices through standardized parts. Modular synthetic biology devices are designed by means of an adequate elimination of cross-talk that makes circuits orthogonal and specific. To that end, synthetic constructs need to be adequately optimized through in silico modeling by choosing the right complement of genetic parts and by experimental tuning through directed evolution and craftsmanship. In this review, we consider an additional and complementary tool available to the synthetic biologist for innovative design and successful construction of desired circuit functionalities: biological synergies. Synergy is a prevalent emergent property in biological systems that arises from the concerted action of multiple factors producing an amplification or cancelation effect compared with individual actions alone. Synergies appear in domains as diverse as those involved in chemical and protein activity, polypharmacology, and metabolic pathway complementarity. In conventional synthetic biology designs, synergistic cross-talk between parts and modules is generally attenuated in order to verify their orthogonality. Synergistic interactions, however, can induce emergent behavior that might prove useful for synthetic biology applications, like in functional circuit design, multi-drug treatment, or in sensing and delivery devices. Synergistic design principles are therefore complementary to those coming from orthogonal design and may provide added value to synthetic biology applications. The appropriate modeling, characterization, and design of synergies between biological parts and units will allow the discovery of yet unforeseeable, novel synthetic biology applications.

Characterization of an innovative method for RuO2 deposition using Electron Microscopy

DEFF Research Database (Denmark)

Cavalca, Filippo

Many photocatalysts work better or exclusively when a suitable cocatalyst, such as RuO2, is deposited on their surface. An innovative method of RuO2 deposition has been found to improve the performance of photocatalysts such as (Ga1-xZnx)(N1-xOx), WO3, SrTiO3 and TiO2. Here we use high angle annu...

Innovation, Procurement and Construction Industry Development

Directory of Open Access Journals (Sweden)

Geard de Valence

2010-12-01

Full Text Available The implications for analysis of innovation in construction of theoretical developments in industrial organisation are considered in this research, as an attempt to outline a new approach to construction innovation incorporating the ideas found in knowledge based, technology centred models. The paper firstly summarises characteristics of the construction industry, focusing on their effects on innovation, before surveying some of the ideas about the sources of innovation and the expansion and application of knowledge. Construction can be seen as an industry with limited scope for knowledge externalities, where the procurement methods used by the industry’s clients do not pay for innovation. The following discussion uses recent developments in the research on the economics of innovation and industrial organization theory, such as research intensity and the endogenous sunk costs in competitive, fragmented, low research intensity industries. The effects on R&D of procurement methods and on industry structure are discussed, with a focus on the appropriability of innovations and the role of the client on the Heathrow Terminal 5 project. The paper concludes that the procurement methods used for building and construction projects appears to be a determining factor in the level of innovation in the construction industry

Chitin Extraction from Crustacean Shells Using Biological Methods – A Review

Directory of Open Access Journals (Sweden)

Wassila Arbia

2013-01-01

Full Text Available After cellulose, chitin is the most widespread biopolymer in nature. Chitin and its derivatives have great economic value because of their biological activities and their industrial and biomedical applications. It can be extracted from three sources, namely crustaceans, insects and microorganisms. However, the main commercial sources of chitin are shells of crustaceans such as shrimps, crabs, lobsters and krill that are supplied in large quantities by the shellfish processing industries. Extraction of chitin involves two steps, demineralisation and deproteinisation, which can be conducted by two methods, chemical or biological. The chemical method requires the use of acids and bases, while the biological method involves microorganisms. Although lactic acid bacteria are mainly applied, other microbial species including proteolytic bacteria have also been successfully implemented, as well as mixed cultures involving lactic acid-producing bacteria and proteolytic microorganisms. The produced lactic acid allows shell demineralisation, since lactic acid reacts with calcium carbonate, the main mineral component, to form calcium lactate.

Novel production method of innovative antiangiogenic and antitumor small peptides in Escherichia coli

Directory of Open Access Journals (Sweden)

Setrerrahmane S

2017-11-01

increased antiangiogenic effect (>75% of the purified products compared with the single molecules. Meanwhile, MTT assay confirmed their enhanced antitumor activity against gastric cancer cell line MGC-803; however, no significant effect was observed on hepatoma HepG2 cells and no cytotoxicity on normal human lens epithelial cell SRA01/04 and human epithelial esophageal cells.Conclusion: Bifunctional molecules with antiangiogenic and antiproliferative effects were obtained by using this technique, which presents an alternative for small peptide production, instead of the conventional chemical method. The increased molecular weight facilitates the peptide expression with a simultaneous improvement in their stability and biological activity. Keywords: innovative drugs, bifunctional peptides, linkers, auto-induction, antiangiogenic, antitumor

Biosecurity and Open-Source Biology: The Promise and Peril of Distributed Synthetic Biological Technologies.

Science.gov (United States)

Evans, Nicholas G; Selgelid, Michael J

2015-08-01

In this article, we raise ethical concerns about the potential misuse of open-source biology (OSB): biological research and development that progresses through an organisational model of radical openness, deskilling, and innovation. We compare this organisational structure to that of the open-source software model, and detail salient ethical implications of this model. We demonstrate that OSB, in virtue of its commitment to openness, may be resistant to governance attempts.

Treatment of laundry wastewater by biological and electrocoagulation methods.

Science.gov (United States)

Ramcharan, Terelle; Bissessur, Ajay

2017-01-01

The present study describes an improvement in the current electrocoagulation treatment process and focuses on a comparative study for the clean-up of laundry wastewater (LWW) after each wash and rinse cycle by biological and electrocoagulation treatment methods. For biological treatment, the wastewater was treated with a Bacillus strain of aerobic bacteria especially suited for the degradation of fats, lipids, protein, detergents and hydrocarbons. Treatment of the LWW by electrocoagulation involved the oxidation of aluminium metal upon the application of a controlled voltage which produces various aluminium hydroxy species capable of adsorbing pollutants from the wastewater. The efficiency of the clean-up of LWW using each method was assessed by determination of surfactant concentration, chemical oxygen demand and total dissolved solids. A rapid decrease in surfactant concentration was noted within 0.5 hour of electrocoagulation, whereas a notable decrease in the surfactant concentration was observed only after 12 hour of biological treatment. The rapid generation of aluminium hydroxy species in the electrocoagulation cell allowed adsorption of pollutants at a faster rate when compared to the aerobic degradation of the surfactant; hence a reduced period of time is required for treatment of LWW by electrocoagulation.

The method innovation in nuclear equipment quality witness tracing and management

International Nuclear Information System (INIS)

Hao Guang

2012-01-01

The total construction cost of a nuclear power plant, equipment procurement cost accounts for about 47%-53%. Whether the quality of equipment can meet the technical requirements plays a significant role in the operation and maintenance of a nuclear power plant. Only if we adopt effective management can the equipment quality be ensured. As the most important method of quality control, the effective attendance and track of quality witness points has a crucial effect on contract smooth implementation as well. The essay mainly illustrates the method of quality witness point tracing and management and how to incorporate serious minded ideas and all take part in ways into quality management, hoping to offer some enlightenment on the innovation of nuclear power equipment quality management. (author)

Design science research methods and patterns innovating information and communication technology

CERN Document Server

Vaishnavi, Vijay K

2015-01-01

Presenting innovative research methods, this second edition of a bestseller describes a simple and practical methodology for conducting cutting-edge design science research (DSR). It provides comprehensive guidance on how to conduct such research and supplies in-depth treatment of design science theory and the different types of theory that can be generated in design science research.Making novel use of the concept of patterns, it presents 84 research patterns for conducting effective DSR. It emphasizes design science theory throughout and is filled with practical examples of using patterns to

Radiotherapy in prostate cancer. Innovative techniques and current controversies

International Nuclear Information System (INIS)

Geinitz, Hans

2015-01-01

Examines in detail the role of innovative radiation techniques in the management of prostate cancer, including IMRT, IGRT, BART, and modern brachytherapy. Explores a range of current controversies in patient treatment. Intended for both radiation oncologists and urologists. Radiation treatment is rapidly evolving owing to the coordinated research of physicists, engineers, computer and imaging specialists, and physicians. Today, the arsenal of ''high-precision'' or ''targeted'' radiotherapy includes multimodal imaging, in vivo dosimetry, Monte Carlo techniques for dose planning, patient immobilization techniques, intensity-modulated radiotherapy (IMRT), image-guided radiotherapy (IGRT), biologically adapted radiotherapy (BART), quality assurance methods, novel methods of brachytherapy, and, at the far end of the scale, particle beam radiotherapy using protons and carbon ions. These approaches are like pieces of a puzzle that need to be put together to provide the prostate cancer patient with high-level optimized radiation treatment. This book examines in detail the role of the above-mentioned innovative radiation techniques in the management of prostate cancer. In addition, a variety of current controversies regarding treatment are carefully explored, including whether prophylactic treatment of the pelvic lymphatics is essential, the magnitude of the effect of dose escalation, whether a benefit accrues from hypofractionation, and what evidence exists for the superiority of protons or heavy ions. Radiotherapy in Prostate Cancer: Innovative Techniques and Current Controversies is intended for both radiation oncologists and urologists with an interest in the up-to-date capabilities of modern radiation oncology for the treatment of prostate cancer.

Value innovations in accordance to Apple

OpenAIRE

Mertl, Jiří

2011-01-01

This bachelor's thesis is aimed at comparison of value management way of innovations and innovations according to Apple. At the first part there are analyzed theoretical, methodical and practical aspects of both of ways. Key theme for value innovation is value for customer, which is analyzed from both points of view value management and Apple. Except of product innovations there are mentioned for example marketing innovations or process innovations. In last part of the thesis there are demons...

Mothers "Google It Up:" Extending Communication Channel Behavior in Diffusion of Innovations Theory.

Science.gov (United States)

Sundstrom, Beth

2016-01-01

This study employed qualitative methods, conducting 44 in-depth interviews with biological mothers of newborns to understand women's perceptions and use of new media, mass media, and interpersonal communication channels in relation to health issues. Findings contribute to theoretical and practical understandings of the role of communication channels in diffusion of innovations theory. In particular, this study provides a foundation for the use of qualitative research to advance applications of diffusion of innovations theory. Results suggest that participants resisted mass media portrayals of women's health. When faced with a health question, participants uniformly started with the Internet to "Google it up." Findings suggest new media comprise a new communication channel with new rules, serving the functions of both personal and impersonal influence. In particular, pregnancy and the postpartum period emerged as a time when campaign planners can access women in new ways online. As a result, campaign planners could benefit from introducing new ideas online and capitalizing on the strength of weak ties favored in new media. Results expand the innovativeness/needs paradox in diffusion of innovations theory by elaborating on the role of new media to reach underserved populations. These findings provide an opportunity to better understand patient information seeking through the lens of diffusion of innovations theory.

The constitutional protection of trade secrets and patents under the Biologics Price Competition and Innovation Act of 2009.

Science.gov (United States)

Epstein, Richard A

2011-01-01

The Biologics Price Competition and Innovation Act of 2009 ("Biosimilars Act") is for the field of pharmaceutical products the single most important legislative development since passage of the Drug Price Competition and Patent Term Restoration Act of 1984 ("Hatch-Waxman Act"), on which portions of the Biosimilars Act are clearly patterned. Congress revised section 351 of the Public Health Service Act (PHSA) to create a pathway for FDA approval of "biosimilar" biological products. Each biosimilar applicant is required to cite in its application a "reference product" that was approved on the basis of a full application containing testing data and manufacturing information, which is owned and was submitted by another company and much of which constitutes trade secret information subject to constitutional protection. Because the Biosimilars Act authorizes biosimilar applicants to cite these previously approved applications, the implementation of the new legislative scheme raises critical issues under the Fifth Amendment of the Constitution, pursuant to which private property--trade secrets included--may not be taken for public use, without "just compensation." FDA must confront those issues as it implements the scheme set out in the Biosimilars Act. This article will discuss these issues, after providing a brief overview of the Biosimilars Act and a more detailed examination of the law of trade secrets.

Method for increasing nuclear magnetic resonance signals in living biological tissue

International Nuclear Information System (INIS)

Krongrad, A.

1995-01-01

A method of enhancing a magnetic resonance comprising the steps of administering a quantity of a selected magnetic isotope to a living biological tissue at a concentration greater than the naturally occurring concentration of such isotope and detecting magnetic resonance signal from the administered magnetic isotope in the living biological tissue. (author)

Innovating Science Teaching by Participatory Action Research – Reflections from an Interdisciplinary Project of Curriculum Innovation on Teaching about Climate Change

Directory of Open Access Journals (Sweden)

Timo Feierabend

2011-01-01

Full Text Available This paper describes a three-year curriculum innovation project on teaching about climate change. The innovation for this study focused on a socio-critical approach towards teaching climate change in four different teaching domains (biology, chemistry, physics and politics. The teaching itself explicitly aimed at general educational objectives, i.e., fostering students’ communication and evaluation abilities as essential components for preparing young people for active participation in society. Participatory Action Research has been used as a collaborative strategy of cyclical curriculum innovation and research. Using past experiences and selected results from accompanying research, this project and its methodology will be reflected upon from the viewpoint of the chemistry group taking part in the project. Core issues reflected upon include how the project contributed to the creation of feasible curriculum materials, how it led to innovative structures in practice, and whether it supported experienced teachers’ ongoing professional development. General considerations for the process of curriculum innovation will also be derived.

The use of innovative teaching methods subject in training of bachelor «Standardization and metrology»

Directory of Open Access Journals (Sweden)

Yushchik E. V.

2016-04-01

Full Text Available the article considers the application of innovative teaching methods by the example of a method of collaborative learning in the laboratory practice in teaching subject «Network information technologies» to guide the preparation of 27.03.01 «Standardization and metroliya».

Function combined method for design innovation of children's bike

Science.gov (United States)

Wu, Xiaoli; Qiu, Tingting; Chen, Huijuan

2013-03-01

As children mature, bike products for children in the market develop at the same time, and the conditions are frequently updated. Certain problems occur when using a bike, such as cycle overlapping, repeating function, and short life cycle, which go against the principles of energy conservation and the environmental protection intensive design concept. In this paper, a rational multi-function method of design through functional superposition, transformation, and technical implementation is proposed. An organic combination of frog-style scooter and children's tricycle is developed using the multi-function method. From the ergonomic perspective, the paper elaborates on the body size of children aged 5 to 12 and effectively extracts data for a multi-function children's bike, which can be used for gliding and riding. By inverting the body, parts can be interchanged between the handles and the pedals of the bike. Finally, the paper provides a detailed analysis of the components and structural design, body material, and processing technology of the bike. The study of Industrial Product Innovation Design provides an effective design method to solve the bicycle problems, extends the function problems, improves the product market situation, and enhances the energy saving feature while implementing intensive product development effectively at the same time.

The module of methodical support in system of electronic educational resources as the innovative element of the modern maintenance of formation

Directory of Open Access Journals (Sweden)

Ольга Николаевна Крылова

2009-06-01

Full Text Available The article introduces some results of research, which were devoted to evaluation of tearches' mobility to introduce innovations in the contents of education. The author considers innovative potential of modules of the methodical support for system of electronic educational resources.

Mixed-Methods Design in Biology Education Research: Approach and Uses

Science.gov (United States)

Warfa, Abdi-Rizak M.

2016-01-01

Educational research often requires mixing different research methodologies to strengthen findings, better contextualize or explain results, or minimize the weaknesses of a single method. This article provides practical guidelines on how to conduct such research in biology education, with a focus on mixed-methods research (MMR) that uses both…

Innovation in practice, dialogue

DEFF Research Database (Denmark)

Reinhard, CarrieLynn D.

Presentation at the March 19, 2010 project meeting for the Virtual Worlds Research Group.  This presentation is the first report of research conducted in June, 2009, in how the Danish firm Innovation Lab makes sense of innovation as it relates to virtual world technologies.  The method used in th...... in this study was the focus group, modified using Dervin's Sense-Making Methodology.  This presentation focuses on how the members of Innovation Lab defined what is innovation, with discussion on whether or not having a unified definition within the organization makes the most sense....

A discussion of molecular biology methods for protein engineering

CSIR Research Space (South Africa)

Zawaira, A

2011-09-01

Full Text Available A number of molecular biology techniques are available to generate variants from a particular start gene for eventual protein expression. The authors discuss the basic principles of these methods in a repertoire that may be used to achieve...

Evaluation of gene association methods for coexpression network construction and biological knowledge discovery.

Directory of Open Access Journals (Sweden)

Sapna Kumari

Full Text Available BACKGROUND: Constructing coexpression networks and performing network analysis using large-scale gene expression data sets is an effective way to uncover new biological knowledge; however, the methods used for gene association in constructing these coexpression networks have not been thoroughly evaluated. Since different methods lead to structurally different coexpression networks and provide different information, selecting the optimal gene association method is critical. METHODS AND RESULTS: In this study, we compared eight gene association methods - Spearman rank correlation, Weighted Rank Correlation, Kendall, Hoeffding's D measure, Theil-Sen, Rank Theil-Sen, Distance Covariance, and Pearson - and focused on their true knowledge discovery rates in associating pathway genes and construction coordination networks of regulatory genes. We also examined the behaviors of different methods to microarray data with different properties, and whether the biological processes affect the efficiency of different methods. CONCLUSIONS: We found that the Spearman, Hoeffding and Kendall methods are effective in identifying coexpressed pathway genes, whereas the Theil-sen, Rank Theil-Sen, Spearman, and Weighted Rank methods perform well in identifying coordinated transcription factors that control the same biological processes and traits. Surprisingly, the widely used Pearson method is generally less efficient, and so is the Distance Covariance method that can find gene pairs of multiple relationships. Some analyses we did clearly show Pearson and Distance Covariance methods have distinct behaviors as compared to all other six methods. The efficiencies of different methods vary with the data properties to some degree and are largely contingent upon the biological processes, which necessitates the pre-analysis to identify the best performing method for gene association and coexpression network construction.

Key Competencies and Characteristics for Innovative Teaching among Secondary School Teachers: A Mixed-Methods Research

Science.gov (United States)

Zhu, Chang; Wang, Di

2014-01-01

This research aims to understand the key competencies and characteristics for innovative teaching as perceived by Chinese secondary teachers. A mixed-methods research was used to investigate secondary teachers' views. First, a qualitative study was conducted with interviews of teachers to understand the perceived key competencies and…

Evaluation of Students' Perceptions Towards An Innovative Teaching-Learning Method During Pharmacology Revision Classes: Autobiography of Drugs.

Science.gov (United States)

Joshi, Anuradha; Ganjiwale, Jaishree

2015-07-01

Various studies in medical education have shown that active learning strategies should be incorporated into the teaching-learning process to make learning more effective, efficient and meaningful. The aim of this study was to evaluate student's perceptions on an innovative revision method conducted in Pharmacology i.e. in form of Autobiography of Drugs. The main objective of study was to help students revise the core topics in Pharmacology in an interesting way. Questionnaire based survey on a newer method of pharmacology revision in two batches of second year MBBS students of a tertiary care teaching medical college. Various sessions on Autobiography of Drugs were conducted amongst two batches of second year MBBS students, during their Pharmacology revision classes. Student's perceptions were documented with the help of a five point likert scale through a questionnaire regarding quality, content and usefulness of this method. Descriptive analysis. Students of both the batches appreciated the innovative method taken up for revision. The median scores in most of the domains in both batches were four out of five, indicative of good response. Feedback from open-ended questions also revealed that the innovative module on "Autobiography of Drugs" was taken as a positive learning experience by students. Autobiography of drugs has been used to help students recall topics that they have learnt through other teachings methods. Autobiography sessions in Pharmacology during revision slots, can be one of the interesting ways in helping students revise and recall topics which have already been taught in theory classes.

Classification of innovations: approaches and consequences

Directory of Open Access Journals (Sweden)

Jakub Tabas

2011-01-01

Full Text Available Currently, innovations are perceived as a life blood of businesses. The inevitable fact is that even if the innovations have a potential to transform the companies or all the industries, the innovations are high risky. Even though, the second fact is that in order to companies’ development and their survival on the markets, the innovations have become the necessity. In the theory, it is rather difficult to find a comprehensive definition of innovation, and to settle down a general definition of innovation becomes more and more difficult with the growing number of domains where the innovations, or possible innovations start to appear in a form of added value to something that already exist. Definition of innovation has come through a long process of development; from early definition of Schumpeter who has connected innovation especially with changes in products or production processes, to recent definitions based on the added value for a society. One of possible approaches to define the content of innovation is to base the definition on classification of innovation. In the article, the authors provide the analysis of existing classifications of innovations in order to find, respectively in order to define the general content of innovation that would confirm (or reject their definition of innovation derived in the frame of their previous work where they state that innovation is a change that leads to gaining profit for an individual, for business entity, or for society, while the profit is not only the accounting one, but it is the economic profit.The article is based especially on the secondary research while the authors employ the method of analysis with the aim to confront various classification-based definitions of innovation. Then the methods used are especially comparison, analysis and synthesis.

Towards physical principles of biological evolution

Science.gov (United States)

Katsnelson, Mikhail I.; Wolf, Yuri I.; Koonin, Eugene V.

2018-03-01

Biological systems reach organizational complexity that far exceeds the complexity of any known inanimate objects. Biological entities undoubtedly obey the laws of quantum physics and statistical mechanics. However, is modern physics sufficient to adequately describe, model and explain the evolution of biological complexity? Detailed parallels have been drawn between statistical thermodynamics and the population-genetic theory of biological evolution. Based on these parallels, we outline new perspectives on biological innovation and major transitions in evolution, and introduce a biological equivalent of thermodynamic potential that reflects the innovation propensity of an evolving population. Deep analogies have been suggested to also exist between the properties of biological entities and processes, and those of frustrated states in physics, such as glasses. Such systems are characterized by frustration whereby local state with minimal free energy conflict with the global minimum, resulting in ‘emergent phenomena’. We extend such analogies by examining frustration-type phenomena, such as conflicts between different levels of selection, in biological evolution. These frustration effects appear to drive the evolution of biological complexity. We further address evolution in multidimensional fitness landscapes from the point of view of percolation theory and suggest that percolation at level above the critical threshold dictates the tree-like evolution of complex organisms. Taken together, these multiple connections between fundamental processes in physics and biology imply that construction of a meaningful physical theory of biological evolution might not be a futile effort. However, it is unrealistic to expect that such a theory can be created in one scoop; if it ever comes to being, this can only happen through integration of multiple physical models of evolutionary processes. Furthermore, the existing framework of theoretical physics is unlikely to suffice

Methods of Model Reduction for Large-Scale Biological Systems: A Survey of Current Methods and Trends.

Science.gov (United States)

Snowden, Thomas J; van der Graaf, Piet H; Tindall, Marcus J

2017-07-01

Complex models of biochemical reaction systems have become increasingly common in the systems biology literature. The complexity of such models can present a number of obstacles for their practical use, often making problems difficult to intuit or computationally intractable. Methods of model reduction can be employed to alleviate the issue of complexity by seeking to eliminate those portions of a reaction network that have little or no effect upon the outcomes of interest, hence yielding simplified systems that retain an accurate predictive capacity. This review paper seeks to provide a brief overview of a range of such methods and their application in the context of biochemical reaction network models. To achieve this, we provide a brief mathematical account of the main methods including timescale exploitation approaches, reduction via sensitivity analysis, optimisation methods, lumping, and singular value decomposition-based approaches. Methods are reviewed in the context of large-scale systems biology type models, and future areas of research are briefly discussed.

Modeling technology innovation: how science, engineering, and industry methods can combine to generate beneficial socioeconomic impacts.

Science.gov (United States)

Stone, Vathsala I; Lane, Joseph P

2012-05-16

Government-sponsored science, technology, and innovation (STI) programs support the socioeconomic aspects of public policies, in addition to expanding the knowledge base. For example, beneficial healthcare services and devices are expected to result from investments in research and development (R&D) programs, which assume a causal link to commercial innovation. Such programs are increasingly held accountable for evidence of impact-that is, innovative goods and services resulting from R&D activity. However, the absence of comprehensive models and metrics skews evidence gathering toward bibliometrics about research outputs (published discoveries), with less focus on transfer metrics about development outputs (patented prototypes) and almost none on econometrics related to production outputs (commercial innovations). This disparity is particularly problematic for the expressed intent of such programs, as most measurable socioeconomic benefits result from the last category of outputs. This paper proposes a conceptual framework integrating all three knowledge-generating methods into a logic model, useful for planning, obtaining, and measuring the intended beneficial impacts through the implementation of knowledge in practice. Additionally, the integration of the Context-Input-Process-Product (CIPP) model of evaluation proactively builds relevance into STI policies and programs while sustaining rigor. The resulting logic model framework explicitly traces the progress of knowledge from inputs, following it through the three knowledge-generating processes and their respective knowledge outputs (discovery, invention, innovation), as it generates the intended socio-beneficial impacts. It is a hybrid model for generating technology-based innovations, where best practices in new product development merge with a widely accepted knowledge-translation approach. Given the emphasis on evidence-based practice in the medical and health fields and "bench to bedside" expectations for

Evaluation of Students’ Perceptions Towards An Innovative Teaching-Learning Method During Pharmacology Revision Classes: Autobiography of Drugs

Science.gov (United States)

Ganjiwale, Jaishree

2015-01-01

Introduction Various studies in medical education have shown that active learning strategies should be incorporated into the teaching–learning process to make learning more effective, efficient and meaningful. Objectives The aim of this study was to evaluate student’s perceptions on an innovative revision method conducted in Pharmacology i.e. in form of Autobiography of Drugs. The main objective of study was to help students revise the core topics in Pharmacology in an interesting way. Settings and Design Questionnaire based survey on a newer method of pharmacology revision in two batches of second year MBBS students of a tertiary care teaching medical college. Materials and Methods Various sessions on Autobiography of Drugs were conducted amongst two batches of second year MBBS students, during their Pharmacology revision classes. Student’s perceptions were documented with the help of a five point likert scale through a questionnaire regarding quality, content and usefulness of this method. Statistical analysis used Descriptive analysis. Results Students of both the batches appreciated the innovative method taken up for revision. The median scores in most of the domains in both batches were four out of five, indicative of good response. Feedback from open-ended questions also revealed that the innovative module on “Autobiography of Drugs” was taken as a positive learning experience by students. Conclusions Autobiography of drugs has been used to help students recall topics that they have learnt through other teachings methods. Autobiography sessions in Pharmacology during revision slots, can be one of the interesting ways in helping students revise and recall topics which have already been taught in theory classes. PMID:26393138

INNOVATIONS IN EQUIPMENT AND TECHNIQUES FOR THE BIOLOGY TEACHING LABORATORY.

Science.gov (United States)

BARTHELEMY, RICHARD E.; AND OTHERS

LABORATORY TECHNIQUES AND EQUIPMENT APPROPRIATE FOR TEACHING BIOLOGICAL SCIENCE CURRICULUM STUDY BIOLOGY ARE EMPHASIZED. MAJOR CATEGORIES INCLUDE (1) LABORATORY FACILITIES, (2) EQUIPMENT AND TECHNIQUES FOR CULTURE OF MICRO-ORGANISMS, (3) LABORATORY ANIMALS AND THEIR HOUSING, (4) TECHNIQUES FOR STUDYING PLANT GROWTH, (5) TECHNIQUES FOR STUDYING…

Small and Medium Enterprises and Biopharmaceutical Innovations ...

African Journals Online (AJOL)

Small and Medium Enterprises and Biopharmaceutical Innovations in Africa: ... through biotechnological processes with links to biological sources especially those of live ... There are more than 500 biopharmaceutical products that have been ... By Country · List All Titles · Free To Read Titles This Journal is Open Access.

An overview of bioinformatics methods for modeling biological pathways in yeast.

Science.gov (United States)

Hou, Jie; Acharya, Lipi; Zhu, Dongxiao; Cheng, Jianlin

2016-03-01

The advent of high-throughput genomics techniques, along with the completion of genome sequencing projects, identification of protein-protein interactions and reconstruction of genome-scale pathways, has accelerated the development of systems biology research in the yeast organism Saccharomyces cerevisiae In particular, discovery of biological pathways in yeast has become an important forefront in systems biology, which aims to understand the interactions among molecules within a cell leading to certain cellular processes in response to a specific environment. While the existing theoretical and experimental approaches enable the investigation of well-known pathways involved in metabolism, gene regulation and signal transduction, bioinformatics methods offer new insights into computational modeling of biological pathways. A wide range of computational approaches has been proposed in the past for reconstructing biological pathways from high-throughput datasets. Here we review selected bioinformatics approaches for modeling biological pathways inS. cerevisiae, including metabolic pathways, gene-regulatory pathways and signaling pathways. We start with reviewing the research on biological pathways followed by discussing key biological databases. In addition, several representative computational approaches for modeling biological pathways in yeast are discussed. © The Author 2015. Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oup.com.

Methodological classification of innovative engineering projects

NARCIS (Netherlands)

Zwart, S.D.; de Vries, M.J.; Franssen, M.; Vermaas, P.E.; Kroes, P.; Meijers, A.W.M.

2016-01-01

In this chapter we report on and discuss our empirical classification of innovative engineering projects. Basic innovative engineering projects are characterized by their overall goal and accompanying method. On the basis of this goal and method, we classify engineering projects as all falling in

Biosocial Conservation: Integrating Biological and Ethnographic Methods to Study Human-Primate Interactions.

Science.gov (United States)

Setchell, Joanna M; Fairet, Emilie; Shutt, Kathryn; Waters, Siân; Bell, Sandra

2017-01-01

Biodiversity conservation is one of the grand challenges facing society. Many people interested in biodiversity conservation have a background in wildlife biology. However, the diverse social, cultural, political, and historical factors that influence the lives of people and wildlife can be investigated fully only by incorporating social science methods, ideally within an interdisciplinary framework. Cultural hierarchies of knowledge and the hegemony of the natural sciences create a barrier to interdisciplinary understandings. Here, we review three different projects that confront this difficulty, integrating biological and ethnographic methods to study conservation problems. The first project involved wildlife foraging on crops around a newly established national park in Gabon. Biological methods revealed the extent of crop loss, the species responsible, and an effect of field isolation, while ethnography revealed institutional and social vulnerability to foraging wildlife. The second project concerned great ape tourism in the Central African Republic. Biological methods revealed that gorilla tourism poses risks to gorillas, while ethnography revealed why people seek close proximity to gorillas. The third project focused on humans and other primates living alongside one another in Morocco. Incorporating shepherds in the coproduction of ecological knowledge about primates built trust and altered attitudes to the primates. These three case studies demonstrate how the integration of biological and social methods can help us to understand the sustainability of human-wildlife interactions, and thus promote coexistence. In each case, an integrated biosocial approach incorporating ethnographic data produced results that would not otherwise have come to light. Research that transcends conventional academic boundaries requires the openness and flexibility to move beyond one's comfort zone to understand and acknowledge the legitimacy of "other" kinds of knowledge. It is

Modular Applications with Smartphones and Smartpads in Shape, Color and Spectral Measurements for Industry, Biology and Medicine plus Science, Education and Training

International Nuclear Information System (INIS)

Hofmann, Prof Dr Dietrich; Gärtner, Dr Claudia; Dittrich, B Eng Paul-Gerald; Düntsch, B Eng Eric; Kraus, Daniel; Klemm, Dipl-Ing Richard

2013-01-01

Aim of the paper is the demonstration of a paradigm shift in shape, color and spectral measurements in industry, biology and medicine as well as in measurement science, education and training. Laboratory applications will be supplemented and replaced by innovative in-field and point-of-care applications. Innovative functional modules are smartphones and/or smartpads supplemented by additional hardware apps and software apps. Specific examples are given for numerous practical applications concerning optodigital methods. The methodological classification distinguishes between different levels for combinations of hardware apps (hwapps) and software apps (swapps) with smartphones and/or smartpads. These methods are fundamental enablers for the transformation from conventional stationary working places in industry, biology, medicine plus science, education and training towards innovative mobile working places with in-field and point-of-care characteristics as well as mobile open online courses MOOCs. The innovative approach opens so far untapped enormous markets for measurement science and engineering. These working conditions will be very common due to their convenience, reliability and affordability. The fundamental enablers are smartphones and/or smartpads. A highly visible advantage of smartphones and/or smartpads is the huge number of their distribution, their worldwide connectivity via Internet and cloud services and the experienced capabilities of their users for practical operations. Young people are becoming the pioneers

Science Café Course: An Innovative Means of Improving Communication Skills of Undergraduate Biology Majors

Directory of Open Access Journals (Sweden)

Anna Goldina

2013-12-01

Full Text Available To help bridge the increasing gap between scientists and the public, we developed an innovative two-semester course, called Science Café. In this course undergraduate biology majors learn to develop communication skills to be better able to explain science concepts and current developments in science to non-scientists. Students develop and host outreach events on various topics relevant to the community, thereby increasing interactions between budding scientists and the public. Such a Science Cafe course emphasizes development of science communication skills early, at the undergraduate level and empowers students to use their science knowledge in every day interactions with the public to increase science literacy, get involved in the local community and engage the public in a dialogue on various pressing science issues. We believe that undergraduate science majors can be great ambassadors for science and are often overlooked since many aspire to go on to medical/veterinary/pharmacy schools. However, science communication skills are especially important for these types of students because when they become healthcare professionals, they will interact with the public as part of their everyday jobs and can thus be great representatives for the field.

Method of 10B determination in biological specimens

International Nuclear Information System (INIS)

Nikitina, R.G.; Frolova, E.I.

1981-01-01

The paper is concerned with the methods of 10 B determination in biological specimens (blood, skin and tissues of rats). On the basis of investigations conducted there have been proposed films based on cellulose triacetate with optimal characteristics in terms of their possible utilization as solid detectors to record α-particles and recoil nuclei. The conditions of film staining are also discussed

A method for three-dimensional quantitative observation of the microstructure of biological samples

Science.gov (United States)

Wang, Pengfei; Chen, Dieyan; Ma, Wanyun; Wu, Hongxin; Ji, Liang; Sun, Jialin; Lv, Danyu; Zhang, Lu; Li, Ying; Tian, Ning; Zheng, Jinggao; Zhao, Fengying

2009-07-01

Contemporary biology has developed into the era of cell biology and molecular biology, and people try to study the mechanism of all kinds of biological phenomena at the microcosmic level now. Accurate description of the microstructure of biological samples is exigent need from many biomedical experiments. This paper introduces a method for 3-dimensional quantitative observation on the microstructure of vital biological samples based on two photon laser scanning microscopy (TPLSM). TPLSM is a novel kind of fluorescence microscopy, which has excellence in its low optical damage, high resolution, deep penetration depth and suitability for 3-dimensional (3D) imaging. Fluorescent stained samples were observed by TPLSM, and afterward the original shapes of them were obtained through 3D image reconstruction. The spatial distribution of all objects in samples as well as their volumes could be derived by image segmentation and mathematic calculation. Thus the 3-dimensionally and quantitatively depicted microstructure of the samples was finally derived. We applied this method to quantitative analysis of the spatial distribution of chromosomes in meiotic mouse oocytes at metaphase, and wonderful results came out last.

Business Oriented Technological System Analysis (BOTSA) at Eindhoven University of Technology : an innovative learning method to foster entrepreneurship

NARCIS (Netherlands)

Wijnker, M.A.S.G.; van Kasteren, H.; Romijn, H.A.; Taufik, T.; Prabasari, I.; Rineksane, I.A.; Yana, R.; Widowati, R.; Putra Rosyidi, S.A.; Riyadi, S.; Harsanto, P.

BOTSA is an innovative teaching method for students with technical background in the field of sustainable energy technologies and an interest in entrepreneurship. Two core features of this method, namely the connection between a technological analysis and a business case as well as the involvement

Expert evaluation of innovation projects of mining enterprises on the basis of methods of system analysis and fuzzy logics

Directory of Open Access Journals (Sweden)

Pimonov Alexander

2017-01-01

Full Text Available This paper presents the multipurpose approach to evaluation of research and innovation projects based on the method of analysis of hierarchies and fuzzy logics for the mining industry. The approach, implemented as part of a decision support system, can reduce the degree of subjectivity during examinations by taking into account both quantitative and qualitative characteristics of the compared innovative alternatives; it does not depend on specific conditions of examination and allows engagement of experts of various fields of knowledge. The system includes the mechanism of coordination of several experts’ views. Using of fuzzy logics allows evaluating the qualitative characteristics of innovations in the form of formalized logical conclusions.

Radiotherapy in prostate cancer. Innovative techniques and current controversies

Energy Technology Data Exchange (ETDEWEB)

Geinitz, Hans [Krankenhaus der Barmherzigen Schwestern, Linz (Austria). Dept. of Radiation Oncology; Linz Univ. (Austria). Medical Faculty; Roach, Mack III [California Univ., San Francisco, CA (United States). Dept. of Radiation Oncology; Van As, Nicholas (ed.) [The Institute of Cancer Research, Sutton Surrey (United Kingdom)

2015-04-01

Examines in detail the role of innovative radiation techniques in the management of prostate cancer, including IMRT, IGRT, BART, and modern brachytherapy. Explores a range of current controversies in patient treatment. Intended for both radiation oncologists and urologists. Radiation treatment is rapidly evolving owing to the coordinated research of physicists, engineers, computer and imaging specialists, and physicians. Today, the arsenal of ''high-precision'' or ''targeted'' radiotherapy includes multimodal imaging, in vivo dosimetry, Monte Carlo techniques for dose planning, patient immobilization techniques, intensity-modulated radiotherapy (IMRT), image-guided radiotherapy (IGRT), biologically adapted radiotherapy (BART), quality assurance methods, novel methods of brachytherapy, and, at the far end of the scale, particle beam radiotherapy using protons and carbon ions. These approaches are like pieces of a puzzle that need to be put together to provide the prostate cancer patient with high-level optimized radiation treatment. This book examines in detail the role of the above-mentioned innovative radiation techniques in the management of prostate cancer. In addition, a variety of current controversies regarding treatment are carefully explored, including whether prophylactic treatment of the pelvic lymphatics is essential, the magnitude of the effect of dose escalation, whether a benefit accrues from hypofractionation, and what evidence exists for the superiority of protons or heavy ions. Radiotherapy in Prostate Cancer: Innovative Techniques and Current Controversies is intended for both radiation oncologists and urologists with an interest in the up-to-date capabilities of modern radiation oncology for the treatment of prostate cancer.

Innovation and Entrepreneurship in Education

DEFF Research Database (Denmark)

, and mindsets. Focusing on ubiquitous learning and transcending the borders of formal, informal, and non-formal learning, the book presents theoretical models and case studies of initiatives, practices, and projects on how innovative pedagogies and ICT could support the development of innovation......-of-the-art in innovation and entrepreneurship in education as seen through the latest academic studies and business currents.......This book explores the concepts of innovation and entrepreneurship through multiple lenses in the context of education. Mixing equal parts of theory and practice, this volume takes a closer look on how innovation and entrepreneurship are approached around the globe as disciplines, methods...

REVIEW OF SELECTED BIOLOGICAL METHODS OF ASSESSING THE QUALITY OF NATURAL ENVIRONMENT

Directory of Open Access Journals (Sweden)

Monika Beata Jakubus

2015-04-01

Full Text Available The xenobiotics introduced into the environment are the effect of human activities. It is especially soil contamination that leads to degradation of soils, which may finally be referred to the biological imbalance of the ecosystem. Normally chemical methods are used for the assessment of soil’s quality. Unfortunately, they are not always quick and inexpensive. Therefore, the practice and the science at environmental monitoring more frequently employ biological methods. Most of them meet the above mentioned conditions and become a supplement of routine laboratory practices. This publication shows an overview of selected common biological methods used to estimate the quality of the environment. The first part of the paper presents biomonitoring as a first step of environmental control which relies on the observation of indicator organisms. The next section was dedicated to the bioassays, indicating the greater or lesser practical applications confirmed by literature on the subject. Particular attention has been focused on phytotests and the tests based on the invertebrates.

Strategies for improving quality and methods for innovation services

Directory of Open Access Journals (Sweden)

Bajić Milan

2009-01-01

Full Text Available Contemporary concepts of business of service organisations, focus their researches on measuring quality of the services and identification of mistakes. The aim of strategies is the improvement of quality. Marketing concepts shows that the constant creation of new products and the modification of characteristics on the old products, makes possible market strategy that stimulates development of activities. This paper is focusing on the improving of service using the strategies that can innovate and improve the services. Paper seeks to demonstrate one of possible observations and importance of performance, combined with blueprinting of services and benchmarking as a useful strategies for improving and innovation of services.

Strategic Innovation Capacity: A Mixed Method Study on Deliberate Strategic Learning Mechanisms

OpenAIRE

Berghman, Liselore

2006-01-01

textabstractSeveral management scholars have come to propound strategic innovation as an effective means to create new and substantially superior customer value, and to combat firms’ inclination towards strategic convergence. Research on strategic innovation is however still in its infancy, tends to lack scientific rigor and has so far proven unable to provide managers with well-founded insights into the specifics of strategic innovation creation. This research therefore aims to study mechani...

Interpretation of biological and mechanical variations between the Lowry versus Bradford method for protein quantification

OpenAIRE

Tzong-Shi Lu; Szu-Yu Yiao; Kenneth Lim; Roderick V. Jensen; Li-Li Hsiao

2010-01-01

Background: The identification of differences in protein expression resulting from methodical variations is an essential component to the interpretation of true, biologically significant results. Aims: We used the Lowry and Bradford methods- two most commonly used methods for protein quantification, to assess whether differential protein expressions are a result of true biological or methodical variations. Material & Methods: Differential protein expression patterns was assessed by western bl...

An innovative jet boring mining method available for the high grade uranium ore underground deposits

International Nuclear Information System (INIS)

Narcy, J.L.

1996-01-01

An innovative mining method, based on the capability of a high pressure water jet to desaggregate rock, has been conceived and tested with success at the highest grade uranium ore deposit in the world, the Cigar Lake deposit in Saskatchewan, Canada. 113 tonnes of ore at 13% U were mined out by a new jet-boring mining method operated on a semi-industrial basis, in 1992 during the test mining program of Cigar Lake Project. (author). 9 figs

Neural basis of scientific innovation induced by heuristic prototype.

Directory of Open Access Journals (Sweden)

Junlong Luo

Full Text Available A number of major inventions in history have been based on bionic imitation. Heuristics, by applying biological systems to the creation of artificial devices and machines, might be one of the most critical processes in scientific innovation. In particular, prototype heuristics propositions that innovation may engage automatic activation of a prototype such as a biological system to form novel associations between a prototype's function and problem-solving. We speculated that the cortical dissociation between the automatic activation and forming novel associations in innovation is critical point to heuristic creativity. In the present study, novel and old scientific innovations (NSI and OSI were selected as experimental materials in using learning-testing paradigm to explore the neural basis of scientific innovation induced by heuristic prototype. College students were required to resolve NSI problems (to which they did not know the answers and OSI problems (to which they knew the answers. From two fMRI experiments, our results showed that the subjects could resolve NSI when provided with heuristic prototypes. In Experiment 1, it was found that the lingual gyrus (LG; BA18 might be related to prototype heuristics in college students resolving NSI after learning a relative prototype. In Experiment 2, the LG (BA18 and precuneus (BA31 were significantly activated for NSI compared to OSI when college students learned all prototypes one day before the test. In addition, the mean beta-values of these brain regions of NSI were all correlated with the behavior accuracy of NSI. As our hypothesis indicated, the findings suggested that the LG might be involved in forming novel associations using heuristic information, while the precuneus might be involved in the automatic activation of heuristic prototype during scientific innovation.

Neural basis of scientific innovation induced by heuristic prototype.

Science.gov (United States)

Luo, Junlong; Li, Wenfu; Qiu, Jiang; Wei, Dongtao; Liu, Yijun; Zhang, Qinlin

2013-01-01

A number of major inventions in history have been based on bionic imitation. Heuristics, by applying biological systems to the creation of artificial devices and machines, might be one of the most critical processes in scientific innovation. In particular, prototype heuristics propositions that innovation may engage automatic activation of a prototype such as a biological system to form novel associations between a prototype's function and problem-solving. We speculated that the cortical dissociation between the automatic activation and forming novel associations in innovation is critical point to heuristic creativity. In the present study, novel and old scientific innovations (NSI and OSI) were selected as experimental materials in using learning-testing paradigm to explore the neural basis of scientific innovation induced by heuristic prototype. College students were required to resolve NSI problems (to which they did not know the answers) and OSI problems (to which they knew the answers). From two fMRI experiments, our results showed that the subjects could resolve NSI when provided with heuristic prototypes. In Experiment 1, it was found that the lingual gyrus (LG; BA18) might be related to prototype heuristics in college students resolving NSI after learning a relative prototype. In Experiment 2, the LG (BA18) and precuneus (BA31) were significantly activated for NSI compared to OSI when college students learned all prototypes one day before the test. In addition, the mean beta-values of these brain regions of NSI were all correlated with the behavior accuracy of NSI. As our hypothesis indicated, the findings suggested that the LG might be involved in forming novel associations using heuristic information, while the precuneus might be involved in the automatic activation of heuristic prototype during scientific innovation.

THE ADAPTIVE NATURE OF MANAGING SOFTWARE INNOVATION

OpenAIRE

Mihai Liviu Despa

2013-01-01

The focus of this article is pointed at adaptive management in the context of innovative software projects. Software development is presented through the filter of innovation. The aspects that differentiate software innovation from any other kind of innovation are highlighted. Adaptive management is addressed from a general point of view. The circumstances that require adaptive management are emphasized. Methods of implementing adaptive management in innovation oriented software projects are ...

A COMMUNITY-BASED COLLEGE STUDY ON ADHERENCE TO DOTS AND RELATED DIAGNOSTIC INNOVATIONS ON AFB STAINING METHOD

Directory of Open Access Journals (Sweden)

Nilotpal Banerjee

2016-10-01

Full Text Available BACKGROUND The geographically isolated underdeveloped state, Tripura of north-eastern region of India has been facing multidimensional problems like unemployment, lack of hygiene, illiteracy, lack of industrialisation, etc. So, it was intended to study the magnitude of reported tuberculosis in the community around the Tripura Medical College through RNTCP. MATERIALS AND METHODS Questionnaire, interrogative methods was primarily adopted. Inspection to different villages around and direct interrogation was done on awareness about the programme. Self-modified innovative method was also adopted to compare scientific reproducibility along with conventional method for AFB staining. RESULTS Analysis of results reveal 28% of people interrogated knew about RNTC programme. 16% of people had seen and heard about the TB staff. 56% of people said that no health staff enquired on other factors like drinking water, mosquito and hygiene, etc. The innovative method of staining proved 100% successful, which was also easier, cheaper and more rapid. CONCLUSION DMC and DOTs services had been quite good as evident from document records and on interrogation to the attendees. 80% of attendees said that they would complete the course of treatment. 83% were happy with the provisions of DOTs and DMC.

Technology Audit: Assessment of Innovative Portfolio

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Kurushina Viktoria

2016-01-01

Full Text Available The article discusses the features of the technological audit performing in the companies of oil and gas sector of Russian economy. To measure the innovations quality level the scale was developed based on the Theory of Inventive Problem Solving and the theory of technological structures. Figures of the innovations quantity by levels, volume and quality of the innovative portfolio are offered for assessment the innovative portfolio quality. The method was tested on an example of oil and gas transporting enterprises. The results of the comparative analysis of innovative portfolio are shown.

Methods of 15N tracer research in biological systems

International Nuclear Information System (INIS)

Hirschberg, K.; Faust, H.

1985-01-01

The application of the stable isotope 15 N is of increasing importance in different scientific disciplines, especially in medicine, agriculture, and the biosciences. The close correlation between the growing interest and improvements of analytical procedures resulted in remarkable advances in the 15 N tracer technique. On the basis of the latest results of 15 N tracer research in life sciences and agriculture methods of 15 N tracer research in biological systems are compiled. The 15 N methodology is considered under three headings: Chemical analysis with a description of methods of sample preparation (including different separation and isolation methods for N-containing substances of biological and agricultural origin) and special procedures converting ammonia to molecular nitrogen. Isotopic analysis with a review on the most important methods of isotopic analysis of nitrogen: mass spectrometry (including the GC-MS technique), emission spectrometry, NMR spectroscopy, and other analytical procedures. 15 N-tracer techniques with a consideration of the role of the isotope dilution analysis as well as different labelling techniques and the mathematical interpretation of tracer data (modelling, N turnover experiments). In these chapters also sources of errors in chemical and isotopic analysis, the accuracy of the different methods and its importance on tracer experiments are discussed. Procedures for micro scale 15 N analysis and aspects of 15 N analysis on the level of natural abundance are considered. Furthermore some remarks on isotope effects in 15 N tracer experiments are made. (author)

An Overview of Biological Macromolecule Crystallization

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Irene Russo Krauss

2013-05-01

Full Text Available The elucidation of the three dimensional structure of biological macromolecules has provided an important contribution to our current understanding of many basic mechanisms involved in life processes. This enormous impact largely results from the ability of X-ray crystallography to provide accurate structural details at atomic resolution that are a prerequisite for a deeper insight on the way in which bio-macromolecules interact with each other to build up supramolecular nano-machines capable of performing specialized biological functions. With the advent of high-energy synchrotron sources and the development of sophisticated software to solve X-ray and neutron crystal structures of large molecules, the crystallization step has become even more the bottleneck of a successful structure determination. This review introduces the general aspects of protein crystallization, summarizes conventional and innovative crystallization methods and focuses on the new strategies utilized to improve the success rate of experiments and increase crystal diffraction quality.

INNOVATION MANAGEMENT TOOLS IN PUBLISHING COMPANIES

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A. Shegda

2013-09-01

Full Text Available This article is devoted to the highly topical issue of modern publishing business as innovation management. introduction of technological innovation, measured as a promising strategy for the development of a constructive industry. The paper deals with main problems in managing of publishing companies. The reference consider of innovation management tools. In the article are exams the problems of books trend decline which require publishers introducing innovative methods of production and distribution. It was found that while the tools can be used. The process of innovation management with the following basic tools like as marketing innovation bench marketing, franchising, engineering innovation. It was found that while the tools can be used. So, the aim of the article is to analyze the modern tools of innovation management in the publishing field.

INFRASTRUCTURE ACTIVATION OF INNOVATIVE DEVELOPMENT OF UKRAINIAN AGRARIAN SECTOR

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Svitlana Syrtseva

2017-12-01

Full Text Available The purpose of the paper is a justification of roles and identifying areas of improving the functioning of innovation infrastructure that will boost innovation in the agricultural sector of Ukraine. Methodology. The methodical basis of the study consists of general scientific cognition methods of economic phenomena and processes. Realization of the work tasks required such methods: theoretical generalization method – during study of scientific papers, legislative and regulatory acts; abstract logical method – to summarize theoretical and methodological provisions, as well as define the research goal; system approach method – identifying areas for improving the functioning of the innovation infrastructure of Ukrainian agrarian sector. Results. Found that in modern development conditions, a network of innovative structures that would provide infrastructure support for innovation development in the agricultural sector should be represented by such institutions as: agricultural innovation clusters, science parks, business incubators, venture funds, advisory services. Taking into account the international experience of the main institutions of infrastructural maintenance of innovative development, suggested areas of improvement and optimization of their formation and functioning to ensure innovation in the agricultural sector of Ukraine. Proved that the formation of agricultural innovation regional clusters should be represented by the following stages: a preliminary analysis and identifying promising areas and productions; selection of the cluster members; the strategic planning stage; setting goals and objectives; work scheduling of the cluster members in order to implement strategies; control over the execution of the approved programs and projects. Taking into account the global model of organization of advisory services, determined that the development of agricultural advisory system should be implemented through extension services

Innovation in a complex environment

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René Pellissier

2012-11-01

Objectives: The study objectives were, firstly, to establish the determinants for complexity and how these can be addressed from a design point of view in order to ensure innovation success and, secondly, to determine how this changes innovation forms and applications. Method: Two approaches were offered to deal with a complex environment – one allowing for complexity for organisational innovation and the other introducing reductionism to minimise complexity. These approaches were examined in a qualitative study involving case studies, open-ended interviews and content analysis between seven developing economy (South African organisations and seven developed economy (US organisations. Results: This study presented a proposed framework for (organisational innovation in a complex environment versus a framework that minimises complexity. The comparative organisational analysis demonstrated the importance of initiating organisational innovation to address internal and external complexity, with the focus being on the leadership actions, their selected operating models and resultant organisational innovations designs, rather than on technological innovations. Conclusion: This study cautioned the preference for technological innovation within organisations and suggested alternative innovation forms (such as organisational and management innovation be used to remain competitive in a complex environment.

Application of the selected physical methods in biological research

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Jaromír Tlačbaba

2013-01-01

Full Text Available This paper deals with the application of acoustic emission (AE, which is a part of the non-destructive methods, currently having an extensive application. This method is used for measuring the internal defects of materials. AE has a high potential in further research and development to extend the application of this method even in the field of process engineering. For that matter, it is the most elaborate acoustic emission monitoring in laboratory conditions with regard to external stimuli. The aim of the project is to apply the acoustic emission recording the activity of bees in different seasons. The mission is to apply a new perspective on the behavior of colonies by means of acoustic emission, which collects a sound propagation in the material. Vibration is one of the integral part of communication in the community. Sensing colonies with the support of this method is used for understanding of colonies biological behavior to stimuli clutches, colony development etc. Simulating conditions supported by acoustic emission monitoring system the illustrate colonies activity. Collected information will be used to represent a comprehensive view of the life cycle and behavior of honey bees (Apis mellifera. Use of information about the activities of bees gives a comprehensive perspective on using of acoustic emission in the field of biological research.

Reverse innovation in maternal health.

Science.gov (United States)

Firoz, Tabassum; Makanga, Prestige Tatenda; Nathan, Hannah L; Payne, Beth; Magee, Laura A

2017-09-01

Reverse innovation, defined as the flow of ideas from low- to high-income settings, is gaining traction in healthcare. With an increasing focus on value, investing in low-cost but effective and innovative solutions can be of mutual benefit to both high- and low-income countries. Reverse innovation has a role in addressing maternal health challenges in high-income countries by harnessing these innovative solutions for vulnerable populations especially in rural and remote regions. In this paper, we present three examples of 'reverse innovation' for maternal health: a low-cost, easy-to-use blood pressure device (CRADLE), a diagnostic algorithm (mini PIERS) and accompanying mobile app (PIERS on the Move), and a novel method for mapping maternal outcomes (MOM).

Innovation activity among nurses: The translation and preliminary validation of the Bricolage Mearsure - a mixed-method study

DEFF Research Database (Denmark)

Krontoft, Anna; Fuglsang, Lars; Kronborg, Hanne

2017-01-01

in healthcare. The aim of this study was therefore to provide an instrument for measuring bricolage activity among nurses, to test the measure and learn about the spread of bricolage in nursing in Denmark. We used a mixed-method design including a translation–back translation, a pre-test and a pilot test......Qualitatively, research has demonstrated the existence of bricolage among healthcare staff, i.e. solving problems on the spot by resources at hand, and its potential to lead to innovation. However, we know little about the spread of bricolage activity and its potential role for innovation...

Innovation and design approaches within prospective ergonomics.

Science.gov (United States)

Liem, André; Brangier, Eric

2012-01-01

In this conceptual article the topic of "Prospective Ergonomics" will be discussed within the context of innovation, design thinking and design processes & methods. Design thinking is essentially a human-centred innovation process that emphasises observation, collaboration, interpretation, visualisation of ideas, rapid concept prototyping and concurrent business analysis, which ultimately influences innovation and business strategy. The objective of this project is to develop a roadmap for innovation, involving consumers, designers and business people in an integrative process, which can be applied to product, service and business design. A theoretical structure comprising of Innovation perspectives (1), Worldviews supported by rationalist-historicist and empirical-idealistic dimensions (2) and Models of "design" reasoning (3) precedes the development and classification of existing methods as well as the introduction of new ones.

Research on process management of nuclear power technological innovation

International Nuclear Information System (INIS)

Yang Hua; Zhou Yu

2005-01-01

Different from the other technological innovation processes, the technological innovation process of nuclear power engineering project is influenced deeply by the extensive environmental factors, the technological innovation of nuclear power engineering project needs to make an effort to reduce environmental uncertainty. This paper had described the mechanism of connection technological innovation process of nuclear power engineering project with environmental factors, and issued a feasible method based on model of bargaining to incorporate technological innovation process management of nuclear power engineering project with environmental factors. This method has realistic meanings to guide the technological innovation of nuclear power engineering project. (authors)

Method and apparatus to image biological interactions in plants

Science.gov (United States)

Weisenberger, Andrew; Bonito, Gregory M.; Reid, Chantal D.; Smith, Mark Frederick

2015-12-22

A method to dynamically image the actual translocation of molecular compounds of interest in a plant root, root system, and rhizosphere without disturbing the root or the soil. The technique makes use of radioactive isotopes as tracers to label molecules of interest and to image their distribution in the plant and/or soil. The method allows for the study and imaging of various biological and biochemical interactions in the rhizosphere of a plant, including, but not limited to, mycorrhizal associations in such regions.

International Conference on Medical and Biological Engineering 2017

CERN Document Server

2017-01-01

This volume presents the proceedings of the International Conference on Medical and Biological Engineering held from 16 to 18 March 2017 in Sarajevo, Bosnia and Herzegovina. Focusing on the theme of ‘Pursuing innovation. Shaping the future’, it highlights the latest advancements in Biomedical Engineering and also presents the latest findings, innovative solutions and emerging challenges in this field. Topics include: - Biomedical Signal Processing - Biomedical Imaging and Image Processing - Biosensors and Bioinstrumentation - Bio-Micro/Nano Technologies - Biomaterials - Biomechanics, Robotics and Minimally Invasive Surgery - Cardiovascular, Respiratory and Endocrine Systems Engineering - Neural and Rehabilitation Engineering - Molecular, Cellular and Tissue Engineering - Bioinformatics and Computational Biology - Clinical Engineering and Health Technology Assessment - Health Informatics, E-Health and Telemedicine - Biomedical Engineering Education - Pharmaceutical Engineering.

Maximizing Product Innovation through Adaptive Application of User-Centered Methods for Defining Customer Value

Directory of Open Access Journals (Sweden)

Tonje Overvik Olsen

2011-12-01

Full Text Available Establishing deep understanding of customers is a prerequisite to improve success rates of innovations under today’s transient business conditions. This paper summarizes methods and tools to increase customer understanding in new product development. A case study of developing an office chair was conducted, utilizing four such methods (web based survey, interview, observation and workshops to provide directions for later application. Results indicate that methods revealing emotionally-related customer information (workshops and observation are resource-intensive and provide less amount of information directly applicable to the product development team. The opposite is the case for methods providing more functionally-related information (web based survey and interview. The overall conclusion is that the latter methods are more suitable for product improvements, while the former may provide valuable information for creating more differentiated products.

An innovative method for determining the diffusion coefficient of product nuclide

Energy Technology Data Exchange (ETDEWEB)

Chen, Chih Lung [Dept. of Nuclear Back-end Management, Taiwan Power Company, Taipei (China); Wang, Tsing Hai [Dept. Biomedical Engineering and Environment Sciences, National Tsing Hua University, Hsinchu (China)

2017-08-15

Diffusion is a crucial mechanism that regulates the migration of radioactive nuclides. In this study, an innovative numerical method was developed to simultaneously calculate the diffusion coefficient of both parent and, afterward, series daughter nuclides in a sequentially reactive through-diffusion model. Two constructed scenarios, a serial reaction (RN{sub 1} → RN{sub 2} → RN{sub 3}) and a parallel reaction (RN{sub 1} → RN{sub 2}A + RN{sub 2}B), were proposed and calculated for verification. First, the accuracy of the proposed three-member reaction equations was validated using several default numerical experiments. Second, by applying the validated numerical experimental concentration variation data, the as-determined diffusion coefficient of the product nuclide was observed to be identical to the default data. The results demonstrate the validity of the proposed method. The significance of the proposed numerical method will be particularly powerful in determining the diffusion coefficients of systems with extremely thin specimens, long periods of diffusion time, and parent nuclides with fast decay constants.

Forms of treaties for organization of innovative goods marketing

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Veronika A. Per’kova

2016-03-01

Full Text Available Objective to identify various ways of innovative products marketing as well as the contract forms most demanded by innovative business that are used in innovative products marketing. Methods the methodological basis of the study was both general scientific methods systemic structural dialectical formal logical analysis synthesis deduction induction etc. methods the method of a philosophical nature and specific methods the method of dogmatic analysis interpretation of legal norms and legal structures formallegal structuralfunctional. Results it was stated that marketing is the final stage of innovation process which is commercializing the innovation i.e. obtains profit through its sales therefore it is important to allocate the contractual structures that mediate sales and distribution of innovative products. It is shown that using contractual forms of organization of innovative products sales the parties determine the marketing scheme for the produced goods and thereby create modify and stop the property relations of the parties thus the contracts whose ultimate goal of signing and execution is marketing of innovations can be identified as organizational by their legal nature. The contractual forms that mediate marketing of innovative products include the contracts of sale agency agreements presented in the Russian civil legislation by the contract of agency contract of commission and agency agreements as well as franchising agreements. Besides in the practice of civil turnover there are mixed contracts contracts based on the freedom principle and the connecting elements of several contractual structures. Mixed contracts include distributor contracts. Scientific novelty for the first time the article comprehensively defines contractual forms of organization of innovative products marketing depending on the means of its distribution and describes the legal nature of emerging relationships for innovations marketing. Practical significance the main

Method-centered digital communities on protocols.io for fast-paced scientific innovation [version 2; referees: 2 approved

Directory of Open Access Journals (Sweden)

Lori Kindler

2017-06-01

Full Text Available The Internet has enabled online social interaction for scientists beyond physical meetings and conferences. Yet despite these innovations in communication, dissemination of methods is often relegated to just academic publishing. Further, these methods remain static, with subsequent advances published elsewhere and unlinked. For communities undergoing fast-paced innovation, researchers need new capabilities to share, obtain feedback, and publish methods at the forefront of scientific development. For example, a renaissance in virology is now underway given the new metagenomic methods to sequence viral DNA directly from an environment. Metagenomics makes it possible to "see" natural viral communities that could not be previously studied through culturing methods. Yet, the knowledge of specialized techniques for the production and analysis of viral metagenomes remains in a subset of labs.  This problem is common to any community using and developing emerging technologies and techniques. We developed new capabilities to create virtual communities in protocols.io, an open access platform, for disseminating protocols and knowledge at the forefront of scientific development. To demonstrate these capabilities, we present a virology community forum called VERVENet. These new features allow virology researchers to share protocols and their annotations and optimizations, connect with the broader virtual community to share knowledge, job postings, conference announcements through a common online forum, and discover the current literature through personalized recommendations to promote discussion of cutting edge research. Virtual communities in protocols.io enhance a researcher's ability to: discuss and share protocols, connect with fellow community members, and learn about new and innovative research in the field.  The web-based software for developing virtual communities is free to use on protocols.io. Data are available through public APIs at protocols.io.

User-driven innovation of an outpatient department

DEFF Research Database (Denmark)

Broberg, Ole; Edwards, Kasper

2012-01-01

This paper presents experiences from a user-driven innovation process of an outpatient department in a hospital. The mixing of methods from user-driven innovation and participatory design contributed to develop an innovative concept of the spatial and organizational design of an outpatient...

Analysis of standard and innovative methods for allocating upstream and refinery GHG emissions to oil products

International Nuclear Information System (INIS)

Moretti, Christian; Moro, Alberto; Edwards, Robert; Rocco, Matteo Vincenzo; Colombo, Emanuela

2017-01-01

Highlights: •Traditional and innovative methods for allocating emissions at refinery level are reviewed. •Added value has been introduced as a novel allocation method. •Hydrogen-based consistency test has been introduced to validate the allocation methods. •Consistent allocation methods assign negative refinery emissions to heavy products. -- Abstract: Alternative fuel policies need accurate and transparent methods to find the embedded carbon intensity of individual refinery products. This study investigates different ways of allocating greenhouse gases emissions deriving from refining and upstream crude oil supply. Allocation methods based on mass, energy content, economic value and, innovatively, added-value, are compared with the marginal refining emissions calculated by CONCAWE’s linear-programming model to the average EU refinery, which has been adopted as reference in EU legislation. Beside the most important transportation fuels (gasoline, diesel, kerosene/jet fuel and heavy fuel oil), the analysis extends to petroleum coke and refinery hydrogen. Moreover, novel criteria, based on the implications due to hydrogen usage by each fuel pathway, have been introduced to test the consistency of the analyzed approaches. It is found that only two economic-based allocation methods are consistent with the introduced criteria. These two methods also give negative refinery emissions for heavy products, which is coherent with the marginal emissions calculated through the CONCAWE refinery model. The recommended allocation methods are transparent and use only publicly available statistical data, so they may be useful not only for future EU legislation, but also in jurisdictions where a representative refinery model is not available.

Biomolecular Sciences: uniting Biology and Chemistry

NARCIS (Netherlands)

Vrieling, Engel

2017-01-01

Biomolecular Sciences: uniting Biology and Chemistry www.rug.nl/research/gbb The scientific discoveries in biomolecular sciences have benefitted enormously from technological innovations. At the Groningen Biomolecular Science and Biotechnology Institute (GBB) we now sequence a genome in days,

Developing Critical Understanding in HRM Students: Using Innovative Teaching Methods to Encourage Deep Approaches to Study

Science.gov (United States)

Butler, Michael J. R.; Reddy, Peter

2010-01-01

Purpose: This paper aims to focus on developing critical understanding in human resource management (HRM) students in Aston Business School, UK. The paper reveals that innovative teaching methods encourage deep approaches to study, an indicator of students reaching their own understanding of material and ideas. This improves student employability…

Social networking and young adults’ drinking practices:innovative qualitative methods for health behavior research

OpenAIRE

Lyons, Antonia C.; Goodwin, Ian; McCreanor, Tim; Griffin, Christine

2015-01-01

Understandings of health behaviours can be enriched by employing innovative qualitative research designs. We draw on research that employed a range of qualitative methods to explore young adults’ drinking behaviours and social networking in Aotearoa New Zealand. We demonstrate the importance of multiple research approaches to situate drinking practices within their broader social context. The research involved three data collection stages. First, 34 friendship focus group discussions were con...

Proposal of Innovative Approaches of Relationship Marketing in Business

Directory of Open Access Journals (Sweden)

Viliam Lendel

2015-03-01

Full Text Available The aim of this paper is to propose innovative approaches to relationship marketing that affect the process of building relationships with customers, based on a detailed analysis of the literary sources and the research. This proposal is supported by the information technology e-CRM and social CRM. The paper contains a detailed description of the procedure for successfully implementing innovative approaches to relationship marketing in business. This should serve mainly to marketing managers as a valuable tool in their use of innovative approaches to relationship marketing, especially in the process of obtaining innovative ideas from customers, in order to identify their needs and requirements. Furthermore, the paper contains the main results of our research aimed at identifying the extent of utilization of innovative approaches to relationship marketing in Slovak businesses. A total of 207 respondents were involved in the research (medium and large businesses and following methods were used: comparative method of qualitative evaluation method, the method of structured and structured interview method, observation, document analysis method (method of content analysis and questionnaire method.

Cosmo Cassette: A Microfluidic Microgravity Microbial System For Synthetic Biology Unit Tests and Satellite Missions

Science.gov (United States)

Berliner, Aaron J.

2013-01-01

Although methods in the design-build-test life cycle of the synthetic biology field have grown rapidly, the expansion has been non-uniform. The design and build stages in development have seen innovations in the form of biological CAD and more efficient means for building DNA, RNA, and other biological constructs. The testing phase of the cycle remains in need of innovation. Presented will be both a theoretical abstraction of biological measurement and a practical demonstration of a microfluidics-based platform for characterizing synthetic biological phenomena. Such a platform demonstrates a design of additive manufacturing (3D printing) for construction of a microbial fuel cell (MFC) to be used in experiments carried out in space. First, the biocompatibility of the polypropylene chassis will be demonstrated. The novel MFCs will be cheaper, and faster to make and iterate through designs. The novel design will contain a manifold switchingdistribution system and an integrated in-chip set of reagent reservoirs fabricated via 3D printing. The automated nature of the 3D printing yields itself to higher resolution switching valves and leads to smaller sized payloads, lower cost, reduced power and a standardized platform for synthetic biology unit tests on Earth and in space. It will be demonstrated that the application of unit testing in synthetic biology will lead to the automatic construction and validation of desired constructs. Unit testing methodologies offer benefits of preemptive problem identification, change of facility, simplicity of integration, ease of documentation, and separation of interface from implementation, and automated design.

Opening up the Agile Innovation Process

Science.gov (United States)

Conboy, Kieran; Donnellan, Brian; Morgan, Lorraine; Wang, Xiaofeng

The objective of this panel is to discuss how firms can operate both an open and agile innovation process. In an era of unprecedented changes, companies need to be open and agile in order to adapt rapidly and maximize their innovation processes. Proponents of agile methods claim that one of the main distinctions between agile methods and their traditional bureaucratic counterparts is their drive toward creativity and innovation. However, agile methods are rarely adopted in their textbook, "vanilla" format, and are usually adopted in part or are tailored or modified to suit the organization. While we are aware that this happens, there is still limited understanding of what is actually happening in practice. Using innovation adoption theory, this panel will discuss the issues and challenges surrounding the successful adoption of agile practices. In addition, this panel will report on the obstacles and benefits reported by over 20 industrial partners engaged in a pan-European research project into agile practices between 2006 and 2009.

ASSESSMENT OF QUALITY OF INNOVATIVE TECHNOLOGIES

Directory of Open Access Journals (Sweden)

Larisa Alexejevna Ismagilova

2016-12-01

Full Text Available We consider the topical issue of implementation of innovative technologies in the aircraft engine building industry. In this industry, products with high reliability requirements are developed and mass-produced. These products combine the latest achievements of science and technology. To make a decision on implementation of innovative technologies, a comprehensive assessment is carried out. It affects the efficiency of the innovations realization. In connection with this, the assessment of quality of innovative technologies is a key aspect in the selection of technological processes for their implementation. Problems concerning assessment of the quality of new technologies and processes of production are considered in the suggested method with respect to new positions. The developed method of assessing the quality of innovative technologies stands out for formed system of the qualimetric characteristics ensuring the effectiveness, efficiency, adaptability of innovative technologies and processes. The feature of suggested system of assessment is that it is based on principles of matching and grouping of quality indicators of innovative technologies and the characteristics of technological processes. The indicators are assessed from the standpoint of feasibility, technologies competiveness and commercial demand of products. In this paper, we discuss the example of implementing the approach of assessing the quality of the innovative technology of high-tech products such as turbine aircraft engine.

5th International Conference on ICT Innovations

CERN Document Server

Anastas, Misev; ICT Innovations 2013 : ICT Innovations and Education

2014-01-01

Information communication technologies have become the necessity in everyday life enabling increased level of communication, processing and information exchange to extent that one could not imagine only a decade ago. Innovations in these technologies open new fields in areas such as: language processing, biology, medicine, robotics, security, urban planning, networking, governance and many others. The applications of these innovations are used to define services that not only ease, but also increase the quality of life. Good education is essential for establishing solid basis of individual development and performance. ICT is integrated part of education at every level and type. Therefore, the special focus should be given to possible deployment of the novel technologies in order to achieve educational paradigms adapted to possible educational consumer specific and individual needs.  This book offers a collection of papers presented at the Fifth International Conference on ICT Innovations held in September 20...

Industrialized Innovation: The Connection of Science & Technology Innovation with Industrial Innovation

Institute of Scientific and Technical Information of China (English)

Yinxing Hong; Yao Lu; Jianghuai Zheng

2017-01-01

In light of the relationship and the current disconnection between science & technology (S&T) innovation and industrial innovation in China,it is necessary to put forward and emphasize the concept of industrialized innovation.Industrialized innovation is the bridge and intermediation between S&T innovation and industrial innovation,which is not only a concept,but also a mechanism and combination force.There are two ways to achieve industrialized innovation:through industry-university-research coordination and through technology entrepreneurship.The meaning of industry-university-research coordination is not about coordination among industry,university and research sectors in an institutional sense;rather it is about the coordination of the functions of cultivation and development in new industries,new technologies,and new talents of industrialized innovation.The incentive mechanism for industrialized innovation should motivate not only innovation but also coordination.Technology entrepreneurship is the industrialization of new technology through business start-ups,which occurs beyond the stage of incubation and development of new technology.The capital of technology entrepreneurship is the set consisting of knowledge capital manifested through technological innovation,human capital manifested through entrepreneurs,and physical capital in the form of venture capital.While physical capital is indispensable,knowledge capital and human capital play the decisive role in technology entrepreneurship.The industrialization of technological innovation involves two requirements:one is to enable the new technology industry to achieve a large scale rapidly,and the other is to fully realize the potential value of the new technology.Both requirements are reliant on effective innovation in business models.

Formation of Innovative Infrastructure of the Industrial Sphere

Directory of Open Access Journals (Sweden)

M. Ya. Veselovsky

2017-01-01

Full Text Available Purpose: in article problems of formation of innovative infrastructure of the industrial sphere in the Russian Federation are investigated, her merits and demerits are considered. In the context of foreign experience the analysis of statistics of development of innovative infrastructure on the basis of which is carried out the main shortcomings constraining efficiency of her work are allocated. Among them lack of cooperation between the organizations of infrastructure, a gap between scientific sector and business community, lack of effective communications between participants of innovative process, information opacity, extremely insufficient financing, and also low demand for innovations from the industrial enterprises, lack of motivation at business to carry out financing of innovative projects. Authors offer mechanisms of formation and management of innovative infrastructure. The purpose of article is increase in efficiency of innovative infrastructure of the industrial sphere. Article tasks: to analyse a condition of innovative infrastructure of the industrial sphere in Russia; to study foreign experience of formation of innovative infrastructure; to reveal shortcomings of functioning of innovative infrastructure; to offer mechanisms of formation and management of innovative infrastructure of the industrial sphere. Methods: hen carrying out a research data of Rosstat, legislative and normative legal acts, state programs of development of innovative activities and the industrial sphere, fundamental and application-oriented works of authoritative scientists in the field of innovative development were the main sources of basic data. The research is based on theoretical methods of scientific knowledge, in particular use of methods of synthesis and deduction, and also methods of empirical knowledge for which allowed to open a range of a set of problems which hinder with innovative development of the industrial sphere. Results: the analysis of the

Strategic aspects of innovation management

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Baruk Jerzy

2017-12-01

Full Text Available Innovations are regarded as the main factor for the development of organizations, regions and whole economies. In practice the innovativeness of economic entities is limited by many factors of internal and external origin. Among the internal factors there are factors associated with management itself focusing the attention of managers on the current problems, limited utilization of modern methods of management, especially strategic management and innovation management. In this publication the emphasis was put on the discussion of the essence of strategic approach to innovation management; the essence of strategic innovations and their role in the development of organizations; three model solutions were proposed, they facilitate: rationalization of decision-making processes for the selection of the strategy of innovative activity; making rational decisions with regard to the moments for the implementation of strategic and facilitating innovations; making rational decisions based on the cycle of strategic innovation in the horizontal and vertical system. Thus, the goal of this publication is to propose a strategic approach to innovation management based not on an intuitive approach, but on a rational approach using chosen model solutions.

WasteWise Resource Management: Innovative Solid Waste Contracting Methods

Science.gov (United States)

Resource management is an innovative contractual partnership between a waste-generating organization and a qualified contractor that changes the nature of current disposal services to support waste minimization and recycling.

Multi-objective optimization of a compact pressurized water nuclear reactor computational model for biological shielding design using innovative materials

Energy Technology Data Exchange (ETDEWEB)

Tunes, M.A., E-mail: matheus.tunes@usp.br [Department of Metallurgical and Materials Engineering, Escola Politécnica da Universidade de São Paulo, Av. Prof. Mello Moraes, 2463 – CEP 05508 – 030 São Paulo (Brazil); Oliveira, C.R.E. de, E-mail: cassiano@unm.edu [Department of Nuclear Engineering, The University of New Mexico, Farris Engineering Center, 221, Albuquerque, NM 87131-1070 (United States); Schön, C.G., E-mail: schoen@usp.br [Department of Metallurgical and Materials Engineering, Escola Politécnica da Universidade de São Paulo, Av. Prof. Mello Moraes, 2463 – CEP 05508 – 030 São Paulo (Brazil)

2017-03-15

Highlights: • Use of two n-γ transport codes leads to optimized model of compact nuclear reactor. • It was possible to safely reduce both weight and volume of the biological shielding. • Best configuration obtained by using new composites for both γ and n attenuation. - Abstract: The aim of the present work is to develop a computational model of a compact pressurized water nuclear reactor (PWR) to investigate the use of innovative materials to enhance the biological shielding effectiveness. Two radiation transport codes were used: the first one – MCNP – for the PWR design and the GEM/EVENT to simulate (in a 1D slab) the behavior of several materials and shielding thickness on gamma and neutron radiation. Additionally MATLAB Optimization Toolbox was used to provide new geometric configurations of the slab aiming at reducing the volume and weight of the walls by means of a cost/objective function. It is demonstrated in the reactor model that the dose rate outside biological shielding has been reduced by one order of magnitude for the optimized model compared with the initial configuration. Volume and weight of the shielding walls were also reduced. The results indicated that one-dimensional deterministic code to reach an optimized geometry and test materials, combined with a three-dimensional model of a compact nuclear reactor in a stochastic code, is a fast and efficient procedure to test shielding performance and optimization before the experimental assessment. A major outcome of this research is that composite materials (ECOMASS 2150TU96) may replace (with advantages) traditional shielding materials without jeopardizing the nuclear power plant safety assurance.

Photon activation method to the investigation of bioobjects content for juridical-biological examination

International Nuclear Information System (INIS)

Dikiy, N.P.; Dyachenko, A.F.; Lyashko, Yu.V.; Medvedeva, E.P.; Uvarov, V.L.; Borovlev, V.I.

2009-01-01

Possibilities of the use of nuclear-physical methods for definition of element composition of biological objects (hair of animals) with the target of receipt of additional evidentiary information at the decision of diagnostics and identification problems within the limits of forensic-biological examination are shown

Cross cutting CFD support to innovative reactor design

International Nuclear Information System (INIS)

Roelofs, Ferry

2009-01-01

Several innovative technologies are under consideration in the world for nuclear energy production. The considered reactor systems apply either gas, sodium, lead, lead-bismuth, supercritical water, or molten salt as coolant. Therefore, methods shall be developed to determine the viability of such systems, but also to support the design of these innovative reactor systems. Computational Fluid Dynamics (CFD) is becoming more and more integrated in the daily practice of thermal-hydraulics researchers and designers. Therefore, it is very important to develop modelling approaches for the application of CFD to the specific requirements for innovative reactors. As many of these innovative reactor designs under consideration are operated using other coolants than water, one has to be careful in adopting methods which are developed for water as a coolant. Cross-cutting CFD challenges, methods and applications are presented for innovative reactors. (author)

Discovery of innovative therapies for rare immune-mediated inflammatory diseases via off-label prescription of biologics: the case of IL-6 receptor blockade in Castleman’s disease

Directory of Open Access Journals (Sweden)

Anne eMusters

2015-12-01

Full Text Available Biologics have revolutionized the field of clinical immunology and proven to be both effective and safe in common immune-mediated inflammatory diseases (IMIDs such as rheumatoid arthritis, inflammatory bowel diseases, and various haematological disorders. However, in patients with rare, severe IMIDs failing on standard therapies it is virtually impossible to conduct randomized controlled trials. Therefore, biologics are usually prescribed off-label in these often severely ill patients. Unfortunately, off-label prescription is sometimes hampered in these diseases due to a lack of reimbursement that is often based on a presumed lack of evidence for effectiveness. In the present article will discuss that off-label prescription of biologics can be a good way to discover new treatments for rare diseases. This will be ilustrated using a case of multicentric Castleman’s disease, an immune-mediated lymphoproliferative disorder, in which off-label tocilizumab (humanized anti-IL-6 receptor blocking antibody treatment resulted in remarkable clinical improvement. Furthermore, we will give recommendations for monitoring efficacy and safety of biologic treatment in rare IMIDs, including the use of registries. In conclusion, we put forward that innovative treatments for rare IMIDs can be discovered via off-label prescription of biologicals, provided that this is based on rational arguments including knowledge of the pathophysiology of the disease.

Strategic Innovation Capacity: A Mixed Method Study on Deliberate Strategic Learning Mechanisms

NARCIS (Netherlands)

L.A. Berghman (Liselore)

2006-01-01

textabstractSeveral management scholars have come to propound strategic innovation as an effective means to create new and substantially superior customer value, and to combat firms’ inclination towards strategic convergence. Research on strategic innovation is however still in its infancy, tends to

Speeding up innovation in agricultural IT

Directory of Open Access Journals (Sweden)

Hannu E.S. Haapala

2013-09-01

Full Text Available An OECD funded research was conducted where methods and processes for speeding up innovation in agriculture were assessed. A global web-based questionnaire was sent to experts in agricultural engineering, research, marketing, education and users of new technologies. Interviews of selected experts were done to deepen the analysis. The results show that considerable part of the relatively slow innovation comes from the fact that users do not trust in new technologies or that the usability of them is unacceptable. The experts suggest that education of the engineers and designers should include more elements from User-Centered Design (UCD and also User-Driven Innovation methods should be more used. As a conclusion a new ‘Dream Team’ of agricultural innovation was developed where user interaction and marketing professionals were given more roles.

Determination of chorionic gonadotrophin. Comparison of biological, immunological and radioimmunological methods

International Nuclear Information System (INIS)

Munier, M.-P.

1978-07-01

Three types of analysis were used to quantify chorionic gonadotrophic hormone: biological determination (rana-reaction); immunological determination (simplified pregnosticon test of the Organon Teknika laboratories); radioimmunological determination (Commissariat a l'Energie Atomique - CEA kits). While the immunochemical technique is specially suited to analysis of the urine, the radioimmunological measurement is carried out on the plasma. This method is extremely sensitive; when traditional biological and immunological methods are used the quantity of CGH detectable is of the order of some hundreds or at best a few tens of international units. The radioimmunological method is a thousand times more sensitive and can therefore measure CGH in amounts of the milli-unit order. Until recently it was not specific enough to differentiate between CGH and LH, but not long ago a β CGH-specific antibody was discovered and it is now possible to detect small amounts of CGH in the presence of LH [fr

Antibiotic innovation for future public health needs.

Science.gov (United States)

Theuretzbacher, U

2017-10-01

The public health threat of antibiotic resistance has gained attention at the highest political levels globally, and recommendations on how to respond are being considered for implementation. Among the recommended responses being explored for their feasibility is the introduction of economic incentives to promote research and development of new antibiotics. There is broad agreement that public investment should stimulate innovation and be linked to policies promoting sustainable and equitable access to antibiotics. Though commonly used, the term 'innovation' is not based on a common understanding. This article aims to initiate discussion on the meaning of 'innovation' in this context. Literature and expert opinion. As the definition of a novel class (novel scaffold, novel pharmacophore), a novel target (novel binding site) and a novel mode of action-the three traditional criteria for 'innovation' in this context-may be confounded by the complexities of antibacterial drug discovery, a biological and outcome-oriented definition of innovation is presented to initiate discussion. Such an expanded definition of innovation in this specific context is based on the overarching requirement that a drug not be affected by cross-resistance to existing drugs in the organisms and indications for which it is intended to be used, and that it have low potential for high-frequency, high-level single-step resistance if intended as a single drug therapy. Policy makers, public health authorities and funders could use such a comprehensive definition of innovation to prioritize where publicly funded incentives should be applied. Copyright © 2017 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.

General method to find the attractors of discrete dynamic models of biological systems

Science.gov (United States)

Gan, Xiao; Albert, Réka

2018-04-01

Analyzing the long-term behaviors (attractors) of dynamic models of biological networks can provide valuable insight. We propose a general method that can find the attractors of multilevel discrete dynamical systems by extending a method that finds the attractors of a Boolean network model. The previous method is based on finding stable motifs, subgraphs whose nodes' states can stabilize on their own. We extend the framework from binary states to any finite discrete levels by creating a virtual node for each level of a multilevel node, and describing each virtual node with a quasi-Boolean function. We then create an expanded representation of the multilevel network, find multilevel stable motifs and oscillating motifs, and identify attractors by successive network reduction. In this way, we find both fixed point attractors and complex attractors. We implemented an algorithm, which we test and validate on representative synthetic networks and on published multilevel models of biological networks. Despite its primary motivation to analyze biological networks, our motif-based method is general and can be applied to any finite discrete dynamical system.

General method to find the attractors of discrete dynamic models of biological systems.

Science.gov (United States)

Gan, Xiao; Albert, Réka

2018-04-01

Analyzing the long-term behaviors (attractors) of dynamic models of biological networks can provide valuable insight. We propose a general method that can find the attractors of multilevel discrete dynamical systems by extending a method that finds the attractors of a Boolean network model. The previous method is based on finding stable motifs, subgraphs whose nodes' states can stabilize on their own. We extend the framework from binary states to any finite discrete levels by creating a virtual node for each level of a multilevel node, and describing each virtual node with a quasi-Boolean function. We then create an expanded representation of the multilevel network, find multilevel stable motifs and oscillating motifs, and identify attractors by successive network reduction. In this way, we find both fixed point attractors and complex attractors. We implemented an algorithm, which we test and validate on representative synthetic networks and on published multilevel models of biological networks. Despite its primary motivation to analyze biological networks, our motif-based method is general and can be applied to any finite discrete dynamical system.

Proposal for a Method for Business Model Performance Assessment: Toward an Experimentation Tool for Business Model Innovation

Directory of Open Access Journals (Sweden)

Antonio Batocchio

2017-04-01

Full Text Available The representation of business models has been recently widespread, especially in the pursuit of innovation. However, defining a company’s business model is sometimes limited to discussion and debates. This study observes the need for performance measurement so that business models can be data-driven. To meet this goal, the work proposed as a hypothesis the creation of a method that combines the practices of the Balanced Scorecard with a method of business models representation – the Business Model Canvas. Such a combination was based on study of conceptual adaptation, resulting in an application roadmap. A case study application was performed to check the functionality of the proposition, focusing on startup organizations. It was concluded that based on the performance assessment of the business model it is possible to propose the search for change through experimentation, a path that can lead to business model innovation.

Stochastic processes, multiscale modeling, and numerical methods for computational cellular biology

CERN Document Server

2017-01-01

This book focuses on the modeling and mathematical analysis of stochastic dynamical systems along with their simulations. The collected chapters will review fundamental and current topics and approaches to dynamical systems in cellular biology. This text aims to develop improved mathematical and computational methods with which to study biological processes. At the scale of a single cell, stochasticity becomes important due to low copy numbers of biological molecules, such as mRNA and proteins that take part in biochemical reactions driving cellular processes. When trying to describe such biological processes, the traditional deterministic models are often inadequate, precisely because of these low copy numbers. This book presents stochastic models, which are necessary to account for small particle numbers and extrinsic noise sources. The complexity of these models depend upon whether the biochemical reactions are diffusion-limited or reaction-limited. In the former case, one needs to adopt the framework of s...

A model for scale up of family health innovations in low-income and middle-income settings: a mixed methods study.

Science.gov (United States)

Bradley, Elizabeth H; Curry, Leslie A; Taylor, Lauren A; Pallas, Sarah Wood; Talbert-Slagle, Kristina; Yuan, Christina; Fox, Ashley; Minhas, Dilpreet; Ciccone, Dana Karen; Berg, David; Pérez-Escamilla, Rafael

2012-01-01

Many family health innovations that have been shown to be both efficacious and cost-effective fail to scale up for widespread use particularly in low-income and middle-income countries (LMIC). Although individual cases of successful scale-up, in which widespread take up occurs, have been described, we lack an integrated and practical model of scale-up that may be applicable to a wide range of public health innovations in LMIC. To develop an integrated and practical model of scale-up that synthesises experiences of family health programmes in LMICs. We conducted a mixed methods study that included in-depth interviews with 33 key informants and a systematic review of peer-reviewed and grey literature from 11 electronic databases and 20 global health agency web sites. We included key informants and studies that reported on the scale up of several family health innovations including Depo-Provera as an example of a product innovation, exclusive breastfeeding as an example of a health behaviour innovation, community health workers (CHWs) as an example of an organisational innovation and social marketing as an example of a business model innovation. Key informants were drawn from non-governmental, government and international organisations using snowball sampling. An article was excluded if the article: did not meet the study's definition of the innovation; did not address dissemination, diffusion, scale up or sustainability of the innovation; did not address low-income or middle-income countries; was superficial in its discussion and/or did not provide empirical evidence about scale-up of the innovation; was not available online in full text; or was not available in English, French, Spanish or Portuguese, resulting in a final sample of 41 peer-reviewed articles and 30 grey literature sources. We used the constant comparative method of qualitative data analysis to extract recurrent themes from the interviews, and we integrated these themes with findings from the

Methods to examine reproductive biology in free-ranging, fully-marine mammals.

Science.gov (United States)

Lanyon, Janet M; Burgess, Elizabeth A

2014-01-01

Historical overexploitation of marine mammals, combined with present-day pressures, has resulted in severely depleted populations, with many species listed as threatened or endangered. Understanding breeding patterns of threatened marine mammals is crucial to assessing population viability, potential recovery and conservation actions. However, determining reproductive parameters of wild fully-marine mammals (cetaceans and sirenians) is challenging due to their wide distributions, high mobility, inaccessible habitats, cryptic lifestyles and in many cases, large body size and intractability. Consequently, reproductive biologists employ an innovative suite of methods to collect useful information from these species. This chapter reviews historic, recent and state-of-the-art methods to examine diverse aspects of reproduction in fully-aquatic mammals.

Publishing activities improves undergraduate biology education.

Science.gov (United States)

Smith, Michelle K

2018-06-01

To improve undergraduate biology education, there is an urgent need for biology instructors to publish their innovative active-learning instructional materials in peer-reviewed journals. To do this, instructors can measure student knowledge about a variety of biology concepts, iteratively design activities, explore student learning outcomes and publish the results. Creating a set of well-vetted activities, searchable through a journal interface, saves other instructors time and encourages the use of active-learning instructional practices. For authors, these publications offer new opportunities to collaborate and can provide evidence of a commitment to using active-learning instructional techniques in the classroom.

Innovation in Innovation Management: The Experience of Petrobras Centers and Networks of Excellence Program

Directory of Open Access Journals (Sweden)

Ana Maria de Britto Pires

2013-04-01

Full Text Available Since 1996, Petrobras – Petróleo Brasileiro S.A., the biggest company in Latin America, has supported the development of a method to structure networks of partnerships called Centers and Networks of Excellence Practice (PCREX. It aims to support the establishment of centers and networks of excellence in areas in which innovation depends heavily on the articulation of various players from outside the company and different internal areas. This article presents the results of the analysis of the PCREX method, including its characterization and field research carried out in eight Centers and Networks of Excellence developed by Petrobras. The field research and subsequent analysis helped identify (i the alignment between the PCREX method and the best innovation management practices and (ii the difficulties faced by new management models based on resource and knowledge sharing, which highlights that organizational innovations need to be able to count on strong institutional support to succeed.

Knowledge base and functionality of concepts of some Filipino biology teachers in five biology topics

Science.gov (United States)

Barquilla, Manuel B.

2018-01-01

This mixed research, is a snapshot of some Filipino Biology teachers' knowledge structure and how their concepts of the five topics in Biology (Photosynthesis, Cellular Respiration, human reproductive system, Mendelian genetics and NonMendelian genetics) functions and develops inside a biology classroom. The study focuses on the six biology teachers and a total of 222 students in their respective classes. Of the Six (6) teachers, three (3) are under the Science curriculum and the other three (3) are under regular curriculum in both public and private schools in Iligan city and Lanao del Norte, Philippines. The study utilized classroom discourses, concept maps, interpretative case-study method, bracketing method, and concept analysis for qualitative part; the quantitative part uses a nonparametric statistical tool, Kendall's tau Coefficient for determining relationship and congruency while measures of central tendencies and dispersion (mean, and standard deviation) for concept maps scores interpretation. Knowledge Base of Biology teachers were evaluated by experts in field of specialization having a doctorate program (e.g. PhD in Genetics) and PhD Biology candidates. The data collection entailed seven (7) months immersion: one (1) month for preliminary phase for the researcher to gain teachers' and students' confidence and the succeeding six (6) months for main observation and data collection. The evaluation of teachers' knowledge base by experts indicated that teachers' knowledge of (65%) is lower than the minimum (75%) recommended by ABD-el-Khalick and Boujaoude (1997). Thus, the experts believe that content knowledge of the teachers is hardly adequate for their teaching assignment. Moreover, the teachers in this study do not systematically use reallife situation to apply the concepts they teach. They can identify concepts too abstract for their student; however, they seldom use innovative ways to bring the discussion to their students' level of readiness and

Innovative antimicrobial interventions for perishable and semiperishable food items

Science.gov (United States)

Yang, Tom C.; Powers, Edmund M.; Sikes, Anthony; Dunne, C. P.

1999-01-01

Recent foodborne outbreaks have emphasized that microbes are evolving strategies that overcome our traditional processing and preservation techniques. Conventional treatments to decontaminate products containing human pathogens are largely ineffective, and new interventions are needed. Such innovative technologies are needed to assure the production and processing of high quality, fresh food items that are less likely to support pathogen growth. Novel chemical and physical treatments are needed that will reduce the risk of microbial contamination while not adversely affecting the quality of the products. This paper presents Natick Lab's efforts in exploring non-traditional methods such as electrolyzed oxidizing water, high intensity light, modified atmospheres and microwave and irradiation technologies, non-traditional chemical treatments including novel sanitizing solutions and natural antimicrobial agents, and non-traditional biological treatments such as the use of bacteriocins. Microbial tests showed significant antifungal, antibacterial effects of these methods, individually and synergistically, with minimum deterioration of food quality as measured by the sensory evaluations. The methods are useful for both military and civilian applications.

A graphical method for reducing and relating models in systems biology.

Science.gov (United States)

Gay, Steven; Soliman, Sylvain; Fages, François

2010-09-15

In Systems Biology, an increasing collection of models of various biological processes is currently developed and made available in publicly accessible repositories, such as biomodels.net for instance, through common exchange formats such as SBML. To date, however, there is no general method to relate different models to each other by abstraction or reduction relationships, and this task is left to the modeler for re-using and coupling models. In mathematical biology, model reduction techniques have been studied for a long time, mainly in the case where a model exhibits different time scales, or different spatial phases, which can be analyzed separately. These techniques are however far too restrictive to be applied on a large scale in systems biology, and do not take into account abstractions other than time or phase decompositions. Our purpose here is to propose a general computational method for relating models together, by considering primarily the structure of the interactions and abstracting from their dynamics in a first step. We present a graph-theoretic formalism with node merge and delete operations, in which model reductions can be studied as graph matching problems. From this setting, we derive an algorithm for deciding whether there exists a reduction from one model to another, and evaluate it on the computation of the reduction relations between all SBML models of the biomodels.net repository. In particular, in the case of the numerous models of MAPK signalling, and of the circadian clock, biologically meaningful mappings between models of each class are automatically inferred from the structure of the interactions. We conclude on the generality of our graphical method, on its limits with respect to the representation of the structure of the interactions in SBML, and on some perspectives for dealing with the dynamics. The algorithms described in this article are implemented in the open-source software modeling platform BIOCHAM available at http

Technical progress, the concept of individualized cancer treatment and the innovation of computer-assisted radiotherapy planning

International Nuclear Information System (INIS)

Merkle, K.; Tanneberger, S.; Matschke, S.

1985-01-01

After a first step of cancerogenesis, the further development of the tumor is an individual process. At the end of this process the tumor is formed as an individual in the individual. The individuality of cancer exists on the level of organs, tissues and cells and includes an individual tumor-host relationship. Today, optimized cancer treatment requires a most precise biological characterization possible of the tumor and of the tumor-host relationship, which will provide objective information about the individual character of every tumor. Routine analysis and strict therapeutic consideration of the clinical and biological individuality of human cancer can offer real chances for the improvement of cancer treatment. A routine acquisition of individual tumor characteristics will be possible only if methods and equipment are available for the registration of suitable parameters. In this context technical innovations have an essential influence on the realization of the concept of individualized cancer treatment. With the method of flow cytophotometry and other techniques examples are given in how far the ideas of individual cancer management can be realized by introduction of new technical solutions into medical research and clinical practice. Unfortunately there is still a lack of methodology in individualizing cancer treatment. The individualization of radiotherapy is connected to an extremely high degree of technical innovations. Particularly this refers to the topometrical description of the target volume in relation to the adjacent anatomical structures and the body contour as well as the fitting of isodoses to the shape and size of the target volume. As an example of innovation of a technical solution for individual radiotherapy planning the computer-assisted radiotherapy planning system DOPSY is described. (author)

Where are All the Female Innovators? Nurses as Innovators in a Public Sector Innovation

Directory of Open Access Journals (Sweden)

Johanna Nählinder

2010-03-01

Full Text Available The field of innovation does not see the innovator and is therefore gender-blind. Still, there is an implicit understanding of who is innovative, and this understanding includes gender and profession of the innovator. The female nurse is not seen as innovative and few innovation policies target her. The lack of innovativeness is due to many factors and two of these are tested empirically in this article: that women work in professions which are not associated with innovation and that women lack confidence to carry out innovative work. The empirical investigation presents evidence in line with both hypothesis and also notes that men and women ends their innovative efforts for different reasons. Therefore, innovation policy targeting these groups mobilises otherwise dormant potential innovators.

Innovation af innovation

DEFF Research Database (Denmark)

Harste, Gorm

2009-01-01

, at innovation af innovationen forsøges gennemført på en måde, hvor tiden kræves at forholde sig til sin egen tidslighed i form af fremtid, nutid, fortid og ikke mindst i form af samtidighed. I tiden skal vi iagttage, hvordan vi iagttager tiden. Vi dobbelt-koder tiden på samme måde, som forskning forsker i...... organisationssystemerne. De to typer systemer kan noget helt bestemt med fænomenet tid. De kan synkronisere. Analyseres organisationssystemer ser vi, imidlertid at innovation kræver ro. Stærkt innovative systemer er militærsystemet og kunstsystemet, der også inddrages, og hvor vi ser paradokset mellem innovation og...... involution. Tid er med et medium og ikke et lufttomt rum. Tid er end ikke en gasart, men udgør et solidt fluidum, som samfundet bader i og flyder i, konstant i bevægelse. Reformer forudsætter former, og innovation forudsætter involution. Kun sådan muliggøres evolution....

Interpretation of biological and mechanical variations between the Lowry versus Bradford method for protein quantification.

Science.gov (United States)

Lu, Tzong-Shi; Yiao, Szu-Yu; Lim, Kenneth; Jensen, Roderick V; Hsiao, Li-Li

2010-07-01

The identification of differences in protein expression resulting from methodical variations is an essential component to the interpretation of true, biologically significant results. We used the Lowry and Bradford methods- two most commonly used methods for protein quantification, to assess whether differential protein expressions are a result of true biological or methodical variations. MATERIAL #ENTITYSTARTX00026; Differential protein expression patterns was assessed by western blot following protein quantification by the Lowry and Bradford methods. We have observed significant variations in protein concentrations following assessment with the Lowry versus Bradford methods, using identical samples. Greater variations in protein concentration readings were observed over time and in samples with higher concentrations, with the Bradford method. Identical samples quantified using both methods yielded significantly different expression patterns on Western blot. We show for the first time that methodical variations observed in these protein assay techniques, can potentially translate into differential protein expression patterns, that can be falsely taken to be biologically significant. Our study therefore highlights the pivotal need to carefully consider methodical approaches to protein quantification in techniques that report quantitative differences.

Composite science and technology innovation index

International Nuclear Information System (INIS)

2011-02-01

This book reports the composite science and technology innovation index with the purpose, process, conception and, the method of evaluation. It also indicates the result of composite science and technology innovation index in 2010, which itemizes the result according to resource, activity network, environment and outcome. The last part records analysis of science and technology innovation in Korea and development plan with various analysis.

The Technology of Introduction of Innovation Methods of Management of Development of the Hotel and Restaurant Enterprises on the Basis of Synergistic Approach

Directory of Open Access Journals (Sweden)

Davydova Oksana Yu.

2018-02-01

Full Text Available The article is aimed at formation of technology of introduction of innovation methods of management of development of hotel and restaurant enterprises on the basis of synergetic approach. The following evolutionary stages of innovative management of enterprises’ development are proposed: preliminary (conjugation; existing (relations and bifurcation; perspective (counterdifferentiation. The technology of introduction of innovation methods of management of development of enterprises of hotel-restaurant industry on the basis of synergistic approach has been developed, confirming existence of synergism in the system of increase of activity potential, opening of new directions of innovative management of development of hotel and restaurant enterprises. The indicators of synergistic effect are determined as follows: high level of performance indicators of enterprise of hotel-restaurant industry; adequate response to changes in the external and internal environment; adaptation to predictable and unpredictable crisis phenomena; improving the quality of products and services; creation and improvement of positive image in both internal and external markets, etc.

Comparison of Unsupervised Vegetation Classification Methods from Vhr Images after Shadows Removal by Innovative Algorithms

Science.gov (United States)

Movia, A.; Beinat, A.; Crosilla, F.

2015-04-01

The recognition of vegetation by the analysis of very high resolution (VHR) aerial images provides meaningful information about environmental features; nevertheless, VHR images frequently contain shadows that generate significant problems for the classification of the image components and for the extraction of the needed information. The aim of this research is to classify, from VHR aerial images, vegetation involved in the balance process of the environmental biochemical cycle, and to discriminate it with respect to urban and agricultural features. Three classification algorithms have been experimented in order to better recognize vegetation, and compared to NDVI index; unfortunately all these methods are conditioned by the presence of shadows on the images. Literature presents several algorithms to detect and remove shadows in the scene: most of them are based on the RGB to HSI transformations. In this work some of them have been implemented and compared with one based on RGB bands. Successively, in order to remove shadows and restore brightness on the images, some innovative algorithms, based on Procrustes theory, have been implemented and applied. Among these, we evaluate the capability of the so called "not-centered oblique Procrustes" and "anisotropic Procrustes" methods to efficiently restore brightness with respect to a linear correlation correction based on the Cholesky decomposition. Some experimental results obtained by different classification methods after shadows removal carried out with the innovative algorithms are presented and discussed.

Synthetic biology in the UK - An outline of plans and progress.

Science.gov (United States)

Clarke, L J; Kitney, R I

2016-12-01

Synthetic biology is capable of delivering new solutions to key challenges spanning the bioeconomy, both nationally and internationally. Recognising this significant potential and the associated need to facilitate its translation and commercialisation the UK government commissioned the production of a national Synthetic Biology Roadmap in 2011, and subsequently provided crucial support to assist its implementation. Critical infrastructural investments have been made, and important strides made towards the development of an effectively connected community of practitioners and interest groups. A number of Synthetic Biology Research Centres, DNA Synthesis Foundries, a Centre for Doctoral Training, and an Innovation Knowledge Centre have been established, creating a nationally distributed and integrated network of complementary facilities and expertise. The UK Synthetic Biology Leadership Council published a UK Synthetic Biology Strategic Plan in 2016, increasing focus on the processes of translation and commercialisation. Over 50 start-ups, SMEs and larger companies are actively engaged in synthetic biology in the UK, and inward investments are starting to flow. Together these initiatives provide an important foundation for stimulating innovation, actively contributing to international research and development partnerships, and helping deliver useful benefits from synthetic biology in response to local and global needs and challenges.

Innovation activity among nurses: The translation and preliminary validation of the Bricolage Measure – a mixed-method study

DEFF Research Database (Denmark)

Krontoft, Anna; Fuglsang, Lars; Kronborg, Hanne

2018-01-01

in healthcare. The aim of this study was therefore to provide an instrument for measuring bricolage activity among nurses, to test the measure and learn about the spread of bricolage in nursing in Denmark. We used a mixed- method design including a translation–back translation, a pre-test and a pilot test......Qualitatively, research has demonstrated the existence of bricolage among healthcare staff, i.e. solving problems on the spot by resources at hand, and its potential to lead to innovation. However, we know little about the spread of bricolage activity and its potential role for innovation...

Innovation and Safety. A prestudy

International Nuclear Information System (INIS)

Rollenhagen, Carl; Hansson, Sven Ove; Hortberg, Johan; Jakobsson, Fredrik; Zhau, Victoria Jing; Mojeri, Sara

2010-04-01

The project summarized in this report was initiated to explore relations between innovation and safety. The first two sections of the report discuss some previously conducted research and give a general background to the subject. It is concluded that safety research and innovation research, by and large, has developed as separate academic disciplines. The concepts of 'innovative safety culture' and 'safe innovation cultures' are suggested as two concepts that can be used to integrate research: innovative safety cultures depart from safety culture research but attempts to introduce an innovative dimension with the aim to create adaptive and innovative safety cultures that efficiently can handle risks arising from existing innovations. Safe innovation cultures have focus on innovation itself, but with the ambition to introduce concepts and methods from safety research in the innovative processes. Three subprojects conducted in the context of the present research are summarized. The first project examines how an existing organization (e.g. SKB - Swedish Nuclear Fuel and Waste Management) attempts to integrate both innovative activities and operative activities in the same organisation. Interviews with key personnel explored different views about how innovative and safety work coexists in the organisation. The second project focuses on how major retrofit projects of a nuclear power plant is managed in parallel to operative activities (e.g. operating the plant on an everyday basis). By means of an innovative technique (e.g. system groups) seminars were held to suggest improvements in the technical change process. The third project conducted a risk analysis of a major organisational change (e.g. control centres for energy distribution). Experiences from the three projects are finally discussed in terms of similarities and differences associated with the cultures for innovation and safety. Suggestions for further research are made

Strategic alliance as a competitive tactics for biological-pharmacy industry.

Science.gov (United States)

Liu, Chuanming; Wang, Ling; Qi, Ershi

2005-01-01

Biological-pharmacy industry refers to biotechnology companies and pharmacy makers. Because of the uncertainty and time-lag in the field of biological-pharmacy, the former is confronted with lacking of capital and the later is faced with improving technique-innovation and product-exploitation. This paper analyzes basic operation principle of strategic alliance, and related strategies are also put forward for biological-pharmacy enterprise to carry out.

A New Method of Creating Technology/Function Matrix for Systematic Innovation without Expert

Directory of Open Access Journals (Sweden)

Tien-Yuan Cheng

2012-02-01

Full Text Available The technology/function matrix is comprised by specific technologies and functions, and through the technology/function matrix we can known what the technologies with functions have opportunities for innovation of product or technology. However, the technology/function matrix is very difficult to create, because the patents need to be read, analyzed and categorized into the technology/function matrix always more than hundreds or thousands. In this research, I propose a method to create a technology/function matrix just need to execute patent search without reading and analyzing patents. Through the proposed method anyone can create a technology/function matrix in a short time without experts’ help even if there are thousands of thousands of patents need to be read and analyzed.

Preparation of Biological Samples Containing Metoprolol and Bisoprolol for Applying Methods for Quantitative Analysis

Directory of Open Access Journals (Sweden)

Corina Mahu Ştefania

2015-12-01

Full Text Available Arterial hypertension is a complex disease with many serious complications, representing a leading cause of mortality. Selective beta-blockers such as metoprolol and bisoprolol are frequently used in the management of hypertension. Numerous analytical methods have been developed for the determination of these substances in biological fluids, such as liquid chromatography coupled with mass spectrometry, gas chromatography coupled with mass spectrometry, high performance liquid chromatography. Due to the complex composition of biological fluids a biological sample pre-treatment before the use of the method for quantitative determination is required in order to remove proteins and potential interferences. The most commonly used methods for processing biological samples containing metoprolol and bisoprolol were identified through a thorough literature search using PubMed, ScienceDirect, and Willey Journals databases. Articles published between years 2005-2015 were reviewed. Protein precipitation, liquid-liquid extraction and solid phase extraction are the main techniques for the extraction of these drugs from plasma, serum, whole blood and urine samples. In addition, numerous other techniques have been developed for the preparation of biological samples, such as dispersive liquid-liquid microextraction, carrier-mediated liquid phase microextraction, hollow fiber-protected liquid phase microextraction, on-line molecularly imprinted solid phase extraction. The analysis of metoprolol and bisoprolol in human plasma, urine and other biological fluids provides important information in clinical and toxicological trials, thus requiring the application of appropriate extraction techniques for the detection of these antihypertensive substances at nanogram and picogram levels.

The effects of IT and open innovation strategies on innovation and financial performances in the banking sector

Directory of Open Access Journals (Sweden)

Tornjanski Vesna

2016-01-01

Full Text Available This paper deals with the effects IT and open innovation strategies have on innovation and financial performances in the Serbian banking sector, using the case study method based on qualitative and quantitative data. The research results point to the need for introducing the concept of open innovation in the banking sector i.e. to adequately incorporate external knowledge in innovation processes using appropriate technologies. Employees and established partnerships with key stakeholders are the two most significant sources for the generation and commercialization of radical innovations, while customers and other sources of knowledge acquisition allow the generation of various knowledge and ideas, and the creation of incremental innovations with the primary purpose of satisfying the end users of banking services, improving existing processes and service quality. To maximize utilization of resources from the open innovation model, the concluding paragraph contains recommendations for managers in the banking sector. The study may be useful for managers in the financial services, banking, IT sector and innovation management.

Innovations (INNO)

International Nuclear Information System (INIS)

1978-01-01

The annual report of the working group on innovations (INNO) deals with the projects carried out by the participating institutes and laboratories in the two fields of 1) application of non-nuclear methods and 2) non-nuclear research and development. (HK) [de

A Method for Determining the Content of Glycoproteins in Biological Samples

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Yang Gao

2016-11-01

Full Text Available The glycoprotein purified from the mycelium extract of Tremella fuciformis was marked with iodine through the iodine substitution reaction. The content of iodine, which is indicative of the amount of the marked tremella glycoprotein (ITG, was detected with Inductively coupled plasma mass spectrometry (ICP-MS. The method was found to be stable, sensitive, and accurate at detecting the content of iodine-substituted glycoprotein, and was used in the quantitative analysis of biological samples, including blood and organs. Different biological samples were collected from rats after oral administration of ITG, and were tested for iodine content by ICP-MS to calculate the amount of ITG in the samples. The results suggested that ICP-MS is a sensitive, stable, and accurate method for detection of iodinated glycoproteins in blood and organs.

The prioritization of open innovation determinants in banking

Directory of Open Access Journals (Sweden)

Tornjanski Vesna

2015-01-01

Full Text Available The research scope of the paper is prioritization of open innovation determinants in banking industry using an integrated application of qualitative and quantitative methods in the evaluation process. The research methods were implemented to compound the depth of experts' knowledge and experience on the one hand, and the precise mathematical reasoning, on the other, thus creating the objective and accurate basis for effective decision making. The overview of determinants of open innovations in banking industry has been obtained from the literature overview and the Delphi study conducted among 51 experts from banks in Serbia. Fifteen significant determinants within five dimensions were further evaluated through AHP decision-making method to prioritize them toward the development of the open innovation in banking. The research results show that effective application of open innovation in banking lies in formal reinforcement by management to integrate innovation into organizational policies and in designing dual structures that facilitate the initiation and implementation of an innovation, i.e. building an ambidextrous organization. The research findings and results introduced in this paper can be usefully applied and widely used by both academics and practitioners who are interested in applying the open innovation concept in banking industry.

Biclustering methods: biological relevance and application in gene expression analysis.

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Ali Oghabian

Full Text Available DNA microarray technologies are used extensively to profile the expression levels of thousands of genes under various conditions, yielding extremely large data-matrices. Thus, analyzing this information and extracting biologically relevant knowledge becomes a considerable challenge. A classical approach for tackling this challenge is to use clustering (also known as one-way clustering methods where genes (or respectively samples are grouped together based on the similarity of their expression profiles across the set of all samples (or respectively genes. An alternative approach is to develop biclustering methods to identify local patterns in the data. These methods extract subgroups of genes that are co-expressed across only a subset of samples and may feature important biological or medical implications. In this study we evaluate 13 biclustering and 2 clustering (k-means and hierarchical methods. We use several approaches to compare their performance on two real gene expression data sets. For this purpose we apply four evaluation measures in our analysis: (1 we examine how well the considered (biclustering methods differentiate various sample types; (2 we evaluate how well the groups of genes discovered by the (biclustering methods are annotated with similar Gene Ontology categories; (3 we evaluate the capability of the methods to differentiate genes that are known to be specific to the particular sample types we study and (4 we compare the running time of the algorithms. In the end, we conclude that as long as the samples are well defined and annotated, the contamination of the samples is limited, and the samples are well replicated, biclustering methods such as Plaid and SAMBA are useful for discovering relevant subsets of genes and samples.

Innovation in a complex environment

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René Pellissier

2012-02-01

Full Text Available Background: As our world becomes more global and competitive yet less predictable, the focus seems to be increasingly on looking to innovation activities to remain competitive. Although there is little doubt that a nation’s competitiveness is embedded in its innovativeness, the complex environment should not be ignored. Complexity is not accounted for in balance sheets or reported in reports; it becomes entrenched in every activity in the organisation. Innovation takes many forms and comes in different shapes.Objectives: The study objectives were, firstly, to establish the determinants for complexity and how these can be addressed from a design point of view in order to ensure innovation success and, secondly, to determine how this changes innovation forms and applications.Method: Two approaches were offered to deal with a complex environment – one allowing for complexity for organisational innovation and the other introducing reductionism to minimise complexity. These approaches were examined in a qualitative study involving case studies, open-ended interviews and content analysis between seven developing economy (South African organisations and seven developed economy (US organisations.Results: This study presented a proposed framework for (organisational innovation in a complex environment versus a framework that minimises complexity. The comparative organisational analysis demonstrated the importance of initiating organisational innovation to address internal and external complexity, with the focus being on the leadership actions, their selected operating models and resultant organisational innovations designs, rather than on technological innovations.Conclusion: This study cautioned the preference for technological innovation within organisations and suggested alternative innovation forms (such as organisational and management innovation be used to remain competitive in a complex environment. 

Product and technology innovation: what can biomimicry inspire?

Science.gov (United States)

Lurie-Luke, Elena

2014-12-01

Biomimicry (bio- meaning life in Greek, and -mimesis, meaning to copy) is a growing field that seeks to interpolate natural biological mechanisms and structures into a wide range of applications. The rise of interest in biomimicry in recent years has provided a fertile ground for innovation. This review provides an eco-system based analysis of biomimicry inspired technology and product innovation. A multi-disciplinary framework has been developed to accomplish this analysis and the findings focus on the areas that have been most strikingly affected by the application of biomimicry and also highlight the emerging trends and opportunity areas. Copyright © 2014 Elsevier Inc. All rights reserved.

Knowledge and Cooperation Determinants of Innovation Networks: A Mixed-Methods Approach to the Case of Portugal

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Hugo Pinto

2015-04-01

Full Text Available Systemic perspectives of innovation integrate complex interrelations among enterprise, science and technology, and governance spheres. Innovation networks are crucial within innovation systems and refer to the linkages of a variety of actors with the purpose of innovation. In this article, the determinants of innovation networks are analyzed using a qualitative original database of online information about 623 organizations in Portugal. A binary econometric regression for all types of entities is estimated. The model underlines that actors using external technologies and promoting knowledge are more likely to innovate. In parallel, actors that are involved in managing and supporting entrepreneurship have a smaller probability to do it. Advanced firms and universities are the actors more willing to dynamically innovate. Specific models for firms and universities create a direct comparison between the determinants in both collectives. While promoting knowledge and specific orientation towards innovation is essential for firms it is not relevant for universities. Managing knowledge is the crucial catalyst for the innovation practices in universities. External technological linkages are essential for both types of actors in the creation of innovation networks. The article concludes with policy implications regarding the support of cooperation activities to instigate innovation.

APPROXIMATING INNOVATION POTENTIAL WITH NEUROFUZZY ROBUST MODEL

Directory of Open Access Journals (Sweden)

Kasa, Richard

2015-01-01

Full Text Available In a remarkably short time, economic globalisation has changed the world’s economic order, bringing new challenges and opportunities to SMEs. These processes pushed the need to measure innovation capability, which has become a crucial issue for today’s economic and political decision makers. Companies cannot compete in this new environment unless they become more innovative and respond more effectively to consumers’ needs and preferences – as mentioned in the EU’s innovation strategy. Decision makers cannot make accurate and efficient decisions without knowing the capability for innovation of companies in a sector or a region. This need is forcing economists to develop an integrated, unified and complete method of measuring, approximating and even forecasting the innovation performance not only on a macro but also a micro level. In this recent article a critical analysis of the literature on innovation potential approximation and prediction is given, showing their weaknesses and a possible alternative that eliminates the limitations and disadvantages of classical measuring and predictive methods.

The impact of methodology in innovation measurement

Energy Technology Data Exchange (ETDEWEB)

Wilhelmsen, L.; Bugge, M.; Solberg, E.

2016-07-01

Innovation surveys and rankings such as the Community Innovation Survey (CIS) and Innovation Union Scoreboard (IUS) have developed into influential diagnostic tools that are often used to categorize countries according to their innovation performance and to legitimise innovation policies. Although a number of ongoing processes are seeking to improve existing frameworks for measuring innovation, there are large methodological differences across countries in the way innovation is measured. This causes great uncertainty regarding a) the coherence between data from innovation surveys, b) actual innovativeness of the economy, and c) the validity of research based on innovation data. Against this background we explore empirically how different survey methods for measuring innovation affect reported innovation performance. The analysis is based on a statistical exercise comparing the results from three different methodological versions of the same survey for measuring innovation in the business enterprise sector in Norway. We find striking differences in reported innovation performance depending on how the surveys are carried out methodologically. The paper concludes that reported innovation performance is highly sensitive to and strongly conditioned by methodological context. This represents a need for increased caution and awareness around data collection and research based on innovation data, and not least in terms of aggregation of data and cross-country comparison. (Author)

Computational structural biology: methods and applications

National Research Council Canada - National Science Library

Schwede, Torsten; Peitsch, Manuel Claude

2008-01-01

... sequencing reinforced the observation that structural information is needed to understand the detailed function and mechanism of biological molecules such as enzyme reactions and molecular recognition events. Furthermore, structures are obviously key to the design of molecules with new or improved functions. In this context, computational structural biology...

Achievements of Theoretical Research on Chinese Technological Innovation

Directory of Open Access Journals (Sweden)

Wang Hanxi

2017-01-01

Full Text Available Using the CNKI database as the sample source, we investigated the makeup of current research results on Chinese technological innovation, and found that the study of Chinese technological innovation consists of nine directions - underlying principles of innovation behavior, concepts of innovation cognition, methods of innovation, behavior of innovation subjects, structure of innovation mediators, innovation capacity, public service system of innovation, policy support system of innovation, and cultural environment of innovation, as well as several issues of innovation, including its behavior mechanism, operational mechanism, work mechanism, modes of implementation, modes of mathematical representation, modes of physical representation, modes of behavioral representation, modes of performance representation, modes of function realization, modes of structure realization, modes of workflow realization, modes of carrier realization, etc. Such a scattered makeup requires us to formulate the system of Chinese technological innovation achievements from the perspective of philosophy of science. This will be an important mission in the study of Chinese technological innovation.

Nitrate removal from drinking water with a focus on biological methods: a review.

Science.gov (United States)

Rezvani, Fariba; Sarrafzadeh, Mohammad-Hossein; Ebrahimi, Sirous; Oh, Hee-Mock

2017-05-31

This article summarizes several developed and industrial technologies for nitrate removal from drinking water, including physicochemical and biological techniques, with a focus on autotrophic nitrate removal. Approaches are primarily classified into separation-based and elimination-based methods according to the fate of the nitrate in water treatment. Biological denitrification as a cost-effective and promising method of biological nitrate elimination is reviewed in terms of its removal process, applicability, efficiency, and associated disadvantages. The various pathways during biological nitrate removal, including assimilatory and dissimilatory nitrate reduction, are also explained. A comparative study was carried out to provide a better understanding of the advantages and disadvantages of autotrophic and heterotrophic denitrification. Sulfur-based and hydrogen-based denitrifications, which are the most common autotrophic processes of nitrate removal, are reviewed with the aim of presenting the salient features of hydrogenotrophic denitrification along with some drawbacks of the technology and research areas in which it could be used but currently is not. The application of algae-based water treatment is also introduced as a nature-inspired approach that may broaden future horizons of nitrate removal technology.

From Innovation Community to Community Innovation User-initiated Innovation in Wireless Leiden

NARCIS (Netherlands)

van Oost, Elizabeth C.J.; Verhaegh, Stefan; Oudshoorn, Nelly E.J.

2009-01-01

The role of users in innovation processes has gained increasing attention in innovation studies, technology studies, and media studies. Scholars have identified users and use practices as a source of innovation. So far, however, little insight has been generated in innovation processes in which

Problems of regional innovation strategy forming

Directory of Open Access Journals (Sweden)

I. M. Golova

2010-09-01

Full Text Available The author considered problems and contradictions of modern innovation policy in Russia. It is shown, that at present time regions are removed from management of science-technical complex and spatial priorities are not produced. It is a serious factor of risk for conservation perspectives of innovation development for Russia. With taking into account of world experience main districts of rise effects regional police were formulated. It is underlined, that creation conditions for transformation of regional authorities in active subjects of innovation policy is necessary condition for building vital innovation system. It is shown, that state innovation policy must be constructed at combination of next principles: a support science-technical potential of regions — generators of innovation and creation conditions for its realization; b using of innovations for evening-out disproportions of social-economic development between regions; c widening powers and financial possibilities of regions at management of innovation climate. Methodical approaches for making effective mechanisms of management of innovation processes of territory are opened. Typology of Russian regions with high and middle degree of innovation climate is proposed, which takes level of science and innovation potential of territory and also degree of comfort of social-economic conditions for development of innovation activity are offered. Peculiarities of innovation strategy for different types of regions are defined. This typology may be used for substantiation spatial priorities of innovation strategy of Russia.

Biological features produced by additive manufacturing processes using vat photopolymerization method

DEFF Research Database (Denmark)

Davoudinejad, Ali; Mendez Ribo, Macarena; Pedersen, David Bue

2017-01-01

of micro biological features by Additive Manufacturing (AM) processes. The study characterizes the additive manufacturing processes for polymeric micro part productions using the vat photopolymerization method. A specifically designed vat photopolymerization AM machine suitable for precision printing...

Impact assessment of agricultural innovations: a review

Directory of Open Access Journals (Sweden)

Juan Carlos Barrientos-Fuentes

2013-04-01

Full Text Available The current conditions of the markets and favorable policies, as well as the progress of science and communications, are promoting further development and diffusion of agricultural innovations, which have effects on different areas of agrarian development. The objective of this paper is to present a review of characteristics of agricultural innovations and their diffusion, adoption and impacts, as well as an update of the types and methods of assessment. Agricultural innovations are not only new or improved products, they are also models and systems, and should have a positive social effect. Innovation areas in developing countries are more concentrated on production and distribution, whereas developed countries concentrate on offering inputs. Investments from the private sector in agricultural innovations are growing faster than those from the public sector. The adoption of innovations is medium-term, and usually less than 100%. The impact of innovations includes intermediate areas, such as institutional, political, scientific and productive areas. The economic efficiency of the investment in innovations is the most often mentioned purpose of impact assessments in the literature. The efficiency analysis (ex-post and its surplus approach is still the most used method for assessing impact of agricultural innovations. Nevertheless, other goals are becoming more important, such as food security, environmental protection and poverty reduction. Livelihood, comprehensive and multidimensional approaches go beyond the economic approach. Moreover, specific models with advantages of prognosis and improved precision are replacing or complementing the classic socio-economic approach

Engineering innovation in healthcare: technology, ethics and persons.

Science.gov (United States)

Bowen, W Richard

2011-01-01

Engineering makes profound contributions to our health. Many of these contributions benefit whole populations, such as clean water and sewage treatment, buildings, dependable sources of energy, efficient harvesting and storage of food, and pharmaceutical manufacture. Thus, ethical assessment of these and other engineering activities has often emphasized benefits to communities. This is in contrast to medical ethics, which has tended to emphasize the individual patient affected by a doctor's actions. However technological innovation is leading to an entanglement of the activities, and hence ethical responsibilities, of healthcare professionals and engineering professionals. The article outlines three categories of innovation: assistive technologies, telehealthcare and quasi-autonomous systems. Approaches to engineering ethics are described and applied to these innovations. Such innovations raise a number of ethical opportunities and challenges, especially as the complexity of the technology increases. In particular the design and operation of the technologies require engineers to seek closer involvement with the persons benefiting from their work. Future innovation will require engineers to have a good knowledge of human biology and psychology. More particularly, healthcare engineers will need to prioritize each person's wellbeing, agency, human relationships and ecological self rather than technology, in the same way that doctors prioritize the treatment of persons rather than their diseases.

Biological characteristics of crucian by quantitative inspection method

Science.gov (United States)

Chu, Mengqi

2015-04-01

Biological characteristics of crucian by quantitative inspection method Through quantitative inspection method , the biological characteristics of crucian was preliminary researched. Crucian , Belongs to Cypriniformes, Cyprinidae, Carassius auratus, is a kind of main plant-eating omnivorous fish,like Gregarious, selection and ranking. Crucian are widely distributed, perennial water all over the country all have production. Determine the indicators of crucian in the experiment, to understand the growth, reproduction situation of crucian in this area . Using the measured data (such as the scale length ,scale size and wheel diameter and so on) and related functional to calculate growth of crucian in any one year.According to the egg shape, color, weight ,etc to determine its maturity, with the mean egg diameter per 20 eggs and the number of eggs per 0.5 grams, to calculate the relative and absolute fecundity of the fish .Measured crucian were female puberty. Based on the relation between the scale diameter and length and the information, linear relationship between crucian scale diameter and length: y=1.530+3.0649. From the data, the fertility and is closely relative to the increase of age. The older, the more mature gonad development. The more amount of eggs. In addition, absolute fecundity increases with the pituitary gland.Through quantitative check crucian bait food intake by the object, reveals the main food, secondary foods, and chance food of crucian ,and understand that crucian degree of be fond of of all kinds of bait organisms.Fish fertility with weight gain, it has the characteristics of species and populations, and at the same tmes influenced by the age of the individual, body length, body weight, environmental conditions (especially the nutrition conditions), and breeding habits, spawning times factors and the size of the egg. After a series of studies of crucian biological character, provide the ecological basis for local crucian's feeding, breeding

The economic rationale for investing decisions innovative projects rationalization of investments for innovative projects

Directory of Open Access Journals (Sweden)

L. O. Zhitinskaya

2017-01-01

Full Text Available The article provides a selection of methods for determining the feasibility of an investment-innovative project. Estimated indicators are identified analytically, on their basis a conclusion is made about the economic efficiency and feasibility of the project, which is the basis of its competitiveness. Such growth analytics is necessary, since the social and economic development of the country and the region largely depends on the investment climate, which is facilitated by the legislation of the Russian Federation (the Tax Code of the Russian Federation, the law of the Russian Federation on the regulation of investment activities, etc.. Since competitiveness is also determined by the economic feasibility and financial solvency of innovative projects, modern information and software, as well as the methodology for project appraisal and the corresponding order of their implementation, are needed. In the Russian Federation, a method is used to assess the efficiency of capital investments in capitalist countries, as well as the methodology of economic (competitive analysis of investment-innovative projects. The basis of the method is that reimbursement of investments occurs in two economic forms: net profit and depreciation (net income. Of the numerous methods for assessing the feasibility of investment, the most often used along with discount methods (taking into account the factor of money changes over time, statistical methods with determining the payback period and the average rate of return on investment. Defined indicators: the net present value (NPV and the internal rate of return (IRR. The methodology specified in the article is useful to the investor in order to rationalize investment flows, helps to achieve the maximum IRR. The implementation of the innovative project serves the competitiveness of the manufacturing enterprise by increasing the technical and technological levels of the products.

Sustainable Innovation: A Competitive Advantage for Innovation Ecosystems

OpenAIRE

Oksanen, Kaisa; Hautamäki, Antti

2015-01-01

In this article, we elaborate the emerging concept of sustainable innovation and analyze the relevance of innovation as a means to solve wicked problems and enhancing sustainable well-being. We also examine the changing conditions for innovation creation: building global knowledge hubs and local innovation ecosystems. As a result, the drivers of innovation and opportunities to utilize the untapped innovation potential of people outside traditional innovation contexts are expand...

EDUCATIONAL INNOVATIONS: AXIOLOGICAL BASES OF MEGALOPOLIS YOUTH’S READINESS

Directory of Open Access Journals (Sweden)

Olga V. Kruzhkova

2015-01-01

Full Text Available The purpose of the present article is to examine the value bases of the readiness for innovations in the modern education of the youth of the megalopolises.Methods. As the methods were used: theoretical analysis and modeling method, as well as a survey of students of megalopolises (n = 1187 by the valuable questionnaire of S. Schwartz.Results. The authors give the description of educational innovations from the perspective of the overall needs of society in an individual which has technological skills and targets in acquiring and operating information. The reorientation of education on advancing development is implemented through numerous tactical and strategic changes in its form, content, methods and structure of the educational system in general. These changes can be united into five groups. Organizational innovations are pointed at changing the structure of education in accordance with the dynamic characteristics of society. Informative innovations suggest differentiation of activities and the level of responsibility of professionals in the same profile. The activity innovations are focused on changing the teachers’ readiness to transform their professional work and the development of their innovative competence. Productive innovations solve the problem of personality development of a professional in accordance with the social mandate. Socio-control innovations are designed to achieve transparency of management education for society. Implementation of the considered innovations is provided by numerous factors, which includes readiness of students to participate in the latest developments of the educational environment. The basis of this readiness contains value orientations, actualizing expectations and targets of young people as participants of innovations. Value priorities of megalopolis youth are highlighted: independence of thoughts and actions, hedonism, reputation and goodwill. On the one hand, these values provide a high readiness

METHODS OF ASSESSMENT OF THE RELATIVE BIOLOGICAL EFFECTIVENESS OF NEUTRONS IN NEUTRON THERAPY

Directory of Open Access Journals (Sweden)

V. A. Lisin

2017-01-01

Full Text Available The relative biological effectiveness (RBE of fast neutrons is an important factor influencing the quality of neutron therapy therefore, the assessment of RBE is of great importance. Experimental and clinical studies as well as different mathematical and radiobiological models are used for assessing RBE. Research is conducted for neutron sources differing in the method of producing particles, energy and energy spectrum. Purpose: to find and analyze the dose-dependence of fast neutron RBE in neutron therapy using the U-120 cyclotron and NG-12I generator. Material and methods: The optimal method for assessing the relative biological effectiveness of neutrons for neutron therapy was described. To analyze the dependence of the RBE on neutron dose, the multi-target model of cell survival was applied. Results: The dependence of the RBE of neutrons produced from the U-120 cyclotron and NG-120 generator on the dose level was found for a single irradiation of biological objects. It was shown that the function of neutron dose was consistent with similar dependencies found by other authors in the experimental and clinical studies.

ACTIVE AND PARTICIPATORY METHODS IN BIOLOGY: CULTIVATION OF CREATIVITY

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Cristina SÎRBU

2011-01-01

Full Text Available Creative achievement is obvious in the arts but it is essential in all other fields including the sciences and business. Creativity allows for the making of connections across different domains of knowledge. It is possible in all areas of human activity and all young people and adults have creative abilities. It is cultivated through rigorous training and by practicing of dynamic capabilities over an extended period of time. Creativity needs time, flow, interaction, suspension of judgement. It is influenced by much more than the shape and content of the formal school curriculum. The roles of teachers are to recognise young people's creative capacities; and to provide the creative climate in which they can be realised. Educational actors have the power to unlock the creative and innovative potential of the young. Creative learning requires innovative and flexible teaching. Creative education involves a balance between teaching knowledge and skills, and encouraging innovation.

Machine-based mapping of innovation portfolios

NARCIS (Netherlands)

de Visser, Matthias; Miao, Shengfa; Englebienne, Gwenn; Sools, Anna Maria; Visscher, Klaasjan

2017-01-01

Machine learning techniques show a great promise for improving innovation portfolio management. In this paper we experiment with different methods to classify innovation projects of a high-tech firm as either explorative or exploitative, and compare the results with a manual, theory-based mapping of

Computational fluid dynamics analysis of an innovative start-up method of high temperature fuel cells using dynamic 3d model

Directory of Open Access Journals (Sweden)

Kupecki Jakub

2017-03-01

Full Text Available The article presents a numerical analysis of an innovative method for starting systems based on high temperature fuel cells. The possibility of preheating the fuel cell stacks from the cold state to the nominal working conditions encounters several limitations related to heat transfer and stability of materials. The lack of rapid and safe start-up methods limits the proliferation of MCFCs and SOFCs. For that reason, an innovative method was developed and verified using the numerical analysis presented in the paper. A dynamic 3D model was developed that enables thermo-fluidic investigations and determination of measures for shortening the preheating time of the high temperature fuel cell stacks. The model was implemented in ANSYS Fluent computational fluid dynamic (CFD software and was used for verification of the proposed start-up method. The SOFC was chosen as a reference fuel cell technology for the study. Results obtained from the study are presented and discussed.

OPEN INNOVATION PROCESSES IN SOCIAL MEDIA PLATFORMS

OpenAIRE

Yang, Yang

2013-01-01

Innovation power has becomes to the priority concern for many enterprises. Open innovation, which acts as a new innovation method, is now applied in many companies due to its unique advantages. On the other hand, social media platforms have been widely accepted by public and it shares an immeasurable business resources. Based on those facts, there must be space to link social media and open innovation together to achieve win-win. The objective was to research the important factors for op...

in OECD countries concerning biological drugs

African Journals Online (AJOL)

Jane

2011-08-22

Aug 22, 2011 ... the pharmaceutical sector about biological drugs come under the umbrella of innovation system of each country. ... The cost of biotechnology R and D within public research centres and ... Existence of a suitable system to protect intellectual property ... biotechnology that provide the capital for industry and.

User-driven innovation in tourism

DEFF Research Database (Denmark)

Hjalager, Anne-Mette; Nordin, Sara

2011-01-01

This literature study reviews user-driven innovation and establishes a typology of its forms in a tourism context. Sixteen methods are distinguishable. They comprise situations where users are actively involved and methods where information is collected without direct user involvement. The nature...... and intensity of the dialogue between companies and their customers are addressed. Drawing on this existing research, the article concludes that there is still little comprehensive follow-up on user-driven innovation in tourism and its impact on quality improvements and assurance. Key areas for future studies...

Eco-Innovation in Circular Agri-Business

Directory of Open Access Journals (Sweden)

Dong-Her Shih

2018-04-01

Full Text Available This study constructs a theory of eco-innovation in circular agri-business. Although previous studies have discussed eco-innovation in circular agri-business, they did not address eco-innovation from the perspective of a closed-loop sustainable supply chain. Hence, this study applied the fuzzy TOPSIS method to conduct the analysis and determine the interrelationship between eco-innovation and the closed-loop concept. The results are consistent with the theory and a significant improvement in terms of the decisive attributes. The findings suggest that improving water management, relationships with suppliers, knowledge sharing, environmental management systems, and new product and service development are the most effective and efficient ways to build eco-innovation in circular agri-business. The managerial and theoretical implications are discussed.

METHODOLOGY TO EVALUATE THE INNOVATIVE ACTIVITY OF THE MEAT INDUSTRY

Directory of Open Access Journals (Sweden)

D. N. Bakaev

2014-01-01

Full Text Available The article considers the methods of estimation of innovative activity of the enterprise. Revealed advantages and disadvantages of the proposed techniques in various publications, devoted to the innovative development. Analysis of the works of domestic and foreign authors showed that the existing methods do not provide an adequate assessment of innovative activity of the enterprise. Asked to enter the integral indicator of innovative activity, which is the criterion of the dynamism of innovative activity of the enterprise, as measured by the speed and volume creation, promotion and use of innovations in economic activity of the enterprise. The proposed system of estimation of innovative activity of the enterprise is based on the following indicators: the ratio of personnel development, the growth rate of financial assets directed on conducting innovative activity of the enterprise, the coefficient for mastering new technologies, the growth rate of intellectual property. The assessment matrix integral indicator of innovative activity of the enterprise reflects the relationship of the indicators of innovative potential and innovative activity and includes a group of indicators, which allows the estimation of innovative activity of enterprises in various spheres of business: technological, organizational, marketing. The main advantages of the developed technique of estimation of level of innovative development of the enterprises of the meat industry is: an assessment of the level in dynamics; complex research of a level of innovation development; the possibility of comparison of actual values with the values of the indicators, assessments United experts. A feature of the proposed method is not only able to measure the level of innovation development in General, but diagnosis of individual factors. This allows you to determine which factors-the Torah must be activated to display the meat industry to a higher level of innovation development.

Innovative biological approaches for monitoring and improving water quality

Directory of Open Access Journals (Sweden)

Sanja eAracic

2015-08-01

Full Text Available Water quality is largely influenced by the abundance and diversity of indigenous microbes present within an aquatic environment. Physical, chemical and biological contaminants from anthropogenic activities can accumulate in aquatic systems causing detrimental ecological consequences. Approaches exploiting microbial processes are now being utilized for the detection, and removal or reduction of contaminants. Contaminants can be identified and quantified in situ using microbial whole-cell biosensors, negating the need for water samples to be tested off-site. Similarly, the innate biodegradative processes can be enhanced through manipulation of the composition and/or function of the indigenous microbial communities present within the contaminated environments. Biological contaminants, such as detrimental/pathogenic bacteria, can be specifically targeted and reduced in number using bacteriophages. This mini-review discusses the potential application of whole-cell microbial biosensors for the detection of contaminants, the exploitation of microbial biodegradative processes for environmental restoration and the manipulation of microbial communities using phages.

Innovative biological approaches for monitoring and improving water quality

Science.gov (United States)

Aracic, Sanja; Manna, Sam; Petrovski, Steve; Wiltshire, Jennifer L.; Mann, Gülay; Franks, Ashley E.

2015-01-01

Water quality is largely influenced by the abundance and diversity of indigenous microbes present within an aquatic environment. Physical, chemical and biological contaminants from anthropogenic activities can accumulate in aquatic systems causing detrimental ecological consequences. Approaches exploiting microbial processes are now being utilized for the detection, and removal or reduction of contaminants. Contaminants can be identified and quantified in situ using microbial whole-cell biosensors, negating the need for water samples to be tested off-site. Similarly, the innate biodegradative processes can be enhanced through manipulation of the composition and/or function of the indigenous microbial communities present within the contaminated environments. Biological contaminants, such as detrimental/pathogenic bacteria, can be specifically targeted and reduced in number using bacteriophages. This mini-review discusses the potential application of whole-cell microbial biosensors for the detection of contaminants, the exploitation of microbial biodegradative processes for environmental restoration and the manipulation of microbial communities using phages. PMID:26322034

Open innovation with an effective open innovation team.

OpenAIRE

Vanvoorden, Jonas

2014-01-01

This master's thesis explores how open innovation teams can successfully support open innovation inside of an organisation. Open innovation is a paradigm introduced by Henry Chesbrough (2003) a decade ago. It expands the innovation potential of organisations by opening them up to new ways of working with external partners. To implement open innovation, many companies rely on a small group of managers named open innovation teams. Although open innovation teams can potentially be vital for impl...

Validation of innovative technologies and strategies for regulatory safety assessment methods: challenges and opportunities.

Science.gov (United States)

Stokes, William S; Wind, Marilyn

2010-01-01

Advances in science and innovative technologies are providing new opportunities to develop test methods and strategies that may improve safety assessments and reduce animal use for safety testing. These include high throughput screening and other approaches that can rapidly measure or predict various molecular, genetic, and cellular perturbations caused by test substances. Integrated testing and decision strategies that consider multiple types of information and data are also being developed. Prior to their use for regulatory decision-making, new methods and strategies must undergo appropriate validation studies to determine the extent that their use can provide equivalent or improved protection compared to existing methods and to determine the extent that reproducible results can be obtained in different laboratories. Comprehensive and optimal validation study designs are expected to expedite the validation and regulatory acceptance of new test methods and strategies that will support improved safety assessments and reduced animal use for regulatory testing.

New perspectives on design and innovation

DEFF Research Database (Denmark)

Alting, Leo; Clausen, Christian; Jørgensen, Ulrik

2007-01-01

The paper reflects on research perspectives dealing with the incorporation of knowledge on use, users, customers and market in the entire innovation process. The point will be made that the support of user oriented innovation processes will have to deal with development of new approaches, methods...

Tracking the emergence of synthetic biology.

Science.gov (United States)

Shapira, Philip; Kwon, Seokbeom; Youtie, Jan

2017-01-01

Synthetic biology is an emerging domain that combines biological and engineering concepts and which has seen rapid growth in research, innovation, and policy interest in recent years. This paper contributes to efforts to delineate this emerging domain by presenting a newly constructed bibliometric definition of synthetic biology. Our approach is dimensioned from a core set of papers in synthetic biology, using procedures to obtain benchmark synthetic biology publication records, extract keywords from these benchmark records, and refine the keywords, supplemented with articles published in dedicated synthetic biology journals. We compare our search strategy with other recent bibliometric approaches to define synthetic biology, using a common source of publication data for the period from 2000 to 2015. The paper details the rapid growth and international spread of research in synthetic biology in recent years, demonstrates that diverse research disciplines are contributing to the multidisciplinary development of synthetic biology research, and visualizes this by profiling synthetic biology research on the map of science. We further show the roles of a relatively concentrated set of research sponsors in funding the growth and trajectories of synthetic biology. In addition to discussing these analyses, the paper notes limitations and suggests lines for further work.

Green Jobs: Definition and Method of Appraisal of Chemical and Biological Risks.

Science.gov (United States)

Cheneval, Erwan; Busque, Marc-Antoine; Ostiguy, Claude; Lavoie, Jacques; Bourbonnais, Robert; Labrèche, France; Bakhiyi, Bouchra; Zayed, Joseph

2016-04-01

In the wake of sustainable development, green jobs are developing rapidly, changing the work environment. However a green job is not automatically a safe job. The aim of the study was to define green jobs, and to establish a preliminary risk assessment of chemical substances and biological agents for workers in Quebec. An operational definition was developed, along with criteria and sustainable development principles to discriminate green jobs from regular jobs. The potential toxicity or hazard associated with their chemical and biological exposures was assessed, and the workers' exposure appraised using an expert assessment method. A control banding approach was then used to assess risks for workers in selected green jobs. A double entry model allowed us to set priorities in terms of chemical or biological risk. Among jobs that present the highest risk potential, several are related to waste management. The developed method is flexible and could be adapted to better appraise the risks that workers are facing or to propose control measures. © The Author 2015. Published by Oxford University Press on behalf of the British Occupational Hygiene Society.

Innovation risks in the market of tourist services

Directory of Open Access Journals (Sweden)

I. A. Kiseleva

2017-01-01

Full Text Available The article defines methods of managing innovation risk in the tourist business. A travel company that implements an innovative strategy of its activities faces special risks that accompany innovation: low demand for innovative services due to lack of information about them, and lack of feedback from consumers of these services; underestimation of the cost of the innovation service; the appearance of so-called problematic innovations, etc. The aim of the work is to study the features of the functioning of the tourism market, as well as to identify problems and prospects for the development of tourism using innovations. The following tasks were accomplished: an analysis of the functioning of the market at the present stage; recommendations are proposed for improving the development of the tourism market with the use of innovations. Methods of cognition, retrospective and documentary analysis, as well as synthesis, generalization, systematization were methods. In the article the assortment of innovative services is considered; proposed the organizational and economic mechanism of risk management in tourism and the main directions for improving management in tourism. Currently, the tourism industry in the regions is represented by a large number of small travel agencies. The fragmentation of the tourism industry creates information problems. In order to coordinate the activities of these firms, it is advisable to create a single center that performs information, coordination and dispatch functions. In addition, measures should be envisaged to eliminate the resulting damage on the basis of recovery technologies. At the same time, for effective management of business risks, effective management is most important, and for consumer risks different types of insurance.

OECD Policy Recommendations on Security for Biological Materials

International Nuclear Information System (INIS)

Radisch, J.

2007-01-01

Biomedical innovations derived from research on pathogenic micro-organisms promise astounding health and economic benefits. Some such biological resources employed in the RandD for diagnostic kits, vaccines and therapeutics, however, possess capacity for dual-use; they may be misused to develop biological weapons. Research facilities entrusted with possession of such dual-use materials have a responsibility to comply with biosecurity measures that are designed to prevent loss or theft and thereby reduce the probability of a bioterrorist attack. The OECD has provided a forum for its Member countries to engage in a dialogue of international co-operation with a view to produce policies that achieve a research environment fortified by biosecurity measures and capable of producing health innovations. In 2007, the OECD developed a risk assessment framework and risk management principles for Biological Resource Centres. Ongoing policy work at the OECD will look to design biosecurity guidelines appropriate to a broader range of facilities in possession of dual-use materials, such as university and industrial laboratories.(author)

Innovation Processes and Entrepreneurial Culture for Radical Innovations

Directory of Open Access Journals (Sweden)

Ľubica Knošková

2015-02-01

Full Text Available To survive and prosper, the organizations need to embed the processes and mechanisms to discover major technology and consumer trends and respond to them through new growth areas. Based on profound literature review providing insight into organizational factors that affect firms’ ability to manage innovation this paper asks which innovation processes and entrepreneurial culture support radical innovations. The aim of the paper is to specify the company behaviour that leads to innovative outputs with high level of novelty in country specific context of Slovakia. We conducted two-stage empirical research in 2009 and 2014 mapping companies’ approach to innovation management during the last 10 years. After surveying 102 firms in the first stage and 287 firms in the second stage we derive success factors for radical innovations. The findings demonstrate growing importance of corporate strategic orientation, highly developed innovation processes and parallel mechanisms for radical innovation, ability to manage internally and externally open innovation and support entrepreneurial culture. This study makes unique contribution to the understanding of innovation processes, organizational factors, and their significance and dynamics. It should attract managerial attention to recognize the importance of innovation management factors for building firm’s innovation competency.

Innovative method of RES integration into the regional energy development scenarios

International Nuclear Information System (INIS)

Klevas, Valentinas; Biekša, Kestutis; Murauskaitė, Lina

2014-01-01

Scarcity or abundance of energy resources usually depends on physical and geographical conditions in the region. However, the energy flow in the region also depends on the efficient use of energy resources, the consumption rate of energy and the possibility to use local renewable and non-renewable energy resources. Production, distribution and the use of energy resources in the region are the challenges for central and local government, business and social service, customers and other stakeholders. Development of regional energy economy should be optimized according to the available energy flow in the region using a network system analysis method, which provides solutions for developing sustainable energy economy models. The network system analysis method enables to optimize the use of local and renewable resources at the regional level and reveals available local energy resources. An efficient use of available regional resources and the use of renewable energy sources (RES) should be the main goals for the development of regional energy system. RES can compete with traditional fossil fuel with the condition that all hidden aspects are revealed. The network system analysis method enables to indicate energy flows in the region as well as indicate pros and cons of using renewable energy technologies. - Highlights: • RES integration into the regional energy development scenarios is done. • Innovative process network system (PNS) analysis method is used. • PNS method is used to optimize the use of local and renewable resources. • Analysis of energy flow in region using PNS method is done

AUTOMATION OF INNOVATIVE DEVELOPMENT MANAGEMENT OF THE RUSSIAN ARCTIC ZONE

Directory of Open Access Journals (Sweden)

O. Klementeva

2015-01-01

Full Text Available In the industrially developed countries about 80–95% of the GDP increase is provided by new knowledge represented by new technologies and machinery. This transition to the new innovative development became possible with the creation of new technological patterns for organization of R&D, industrial and innovative activities. Despite of the fact that the structures of national and regional innovative systems of diff erent countries have much in common which concerns the components, the functional classifi cation and the interaction procedures, the question of theoretical structural description of the regional innovative system seems to be of importance. The object of research is the interaction between the entities of the Russian Arctic innovative system from the viewpoint of the complex information inputs. The subject of research is the model-algorithmic support of the automated system providing for innovative activities within the Russian Arctic zone.The article is aimed to work out the theoretical and practical methods for automation of the regional innovative system management with application of modern information technologies. In order to achieve the specifi ed goal, the following tasks are solved in the article: determining of the modern methods and approaches of organization and management of the information flows within the contemporary business communities; the analysis and structural description of the regional innovative system; working out of the concept for the complex automated information system supporting the innovative activity. The research methods. For solving of the stated tasks some methods and approaches for creating of the social networks, methods of organization of the information fl ows based on the Web 2.0 technology and some expert methods of innovation were used. Finally, the following results were obtained: the structural description of the regional innovative system has been worked out. The main

MODEL OF METHODS OF FORMING BIOLOGICAL PICTURE OF THE WORLD OF SECONDARY SCHOOL PUPILS

Directory of Open Access Journals (Sweden)

Mikhail A. Yakunchev

2016-12-01

Full Text Available Introduction: the problem of development of a model of methods of forming the biological picture of the world of pupils as a multicomponent and integrative expression of the complete educational process is considered in the article. It is stated that the results of the study have theoretical and practical importance for effective subject preparation of senior pupils based on acquiring of systematic and generalized knowledge about wildlife. The correspondence of the main idea of the article to the scientific profile of the journal “Integration of Education” determines the choice of the periodical for publication. Materials and Methods: the results of the analysis of materials on modeling of the educational process, on specific models of the formation of a complete comprehension of the scientific picture of the world and its biological component make it possible to suggest a lack of elaboration of the aspect of pedagogical research under study. Therefore, the search for methods to overcome these gaps and to substantiate a particular model, relevant for its practical application by a teacher, is important. The study was based on the use of methods of theoretical level, including the analysis of pedagogical and methodological literature, modeling and generalized expression of the model of forming the biological picture of the world of secondary school senior pupils, which were of higher priority. Results: the use of models of organization of subject preparation of secondary school pupils takes a priority position, as they help to achieve the desired results of training, education and development. The model of methods of forming a biological picture of the world is represented as a theoretical construct in the unity of objective, substantive, procedural, diagnostic and effective blocks. Discussion and Conclusions: in a generalized form the article expresses the model of methods of forming the biological picture of the world of secondary school

Innovation in medicine and healthcare 2015

CERN Document Server

Torro, Carlos; Tanaka, Satoshi; Howlett, Robert; Jain, Lakhmi

2016-01-01

Innovation in medicine and healthcare is an interdisciplinary research area, which combines the advanced technologies and problem solving skills with medical and biological science. A central theme of this proceedings is Smart Medical and Healthcare Systems (modern intelligent systems for medicine and healthcare), which can provide efficient and accurate solution to problems faced by healthcare and medical practitioners today by using advanced information communication techniques, computational intelligence, mathematics, robotics and other advanced technologies. The techniques developed in this area will have a significant effect on future medicine and healthcare.    The volume includes 53 papers, which present the recent trend and innovations in medicine and healthcare including Medical Informatics; Biomedical Engineering; Management for Healthcare; Advanced ICT for Medical and Healthcare; Simulation and Visualization/VR for Medicine; Statistical Signal Processing and Artificial Intelligence; Smart Medic...

Improving Machining Accuracy of CNC Machines with Innovative Design Methods

Science.gov (United States)

Yemelyanov, N. V.; Yemelyanova, I. V.; Zubenko, V. L.

2018-03-01

The article considers achieving the machining accuracy of CNC machines by applying innovative methods in modelling and design of machining systems, drives and machine processes. The topological method of analysis involves visualizing the system as matrices of block graphs with a varying degree of detail between the upper and lower hierarchy levels. This approach combines the advantages of graph theory and the efficiency of decomposition methods, it also has visual clarity, which is inherent in both topological models and structural matrices, as well as the resiliency of linear algebra as part of the matrix-based research. The focus of the study is on the design of automated machine workstations, systems, machines and units, which can be broken into interrelated parts and presented as algebraic, topological and set-theoretical models. Every model can be transformed into a model of another type, and, as a result, can be interpreted as a system of linear and non-linear equations which solutions determine the system parameters. This paper analyses the dynamic parameters of the 1716PF4 machine at the stages of design and exploitation. Having researched the impact of the system dynamics on the component quality, the authors have developed a range of practical recommendations which have enabled one to reduce considerably the amplitude of relative motion, exclude some resonance zones within the spindle speed range of 0...6000 min-1 and improve machining accuracy.

Collaborative business modeling for systemic and sustainability innovations

DEFF Research Database (Denmark)

Rohrbeck, René; Konnertz, L.; Knab, S.

2013-01-01

Sustainability innovations are characterized by a systemic nature, and require that multiple organizations act in an orchestrated fashion. To jointly identify opportunities and plan sustainability innovations, new methods and approaches are needed. In this article we describe a case study where 8...... firms have collaborated to envision and create new business models in the energy industry. After describing this collaborative business modelling (CBM) approach, we discuss its strengths and limitations and compare it to two alternative methods of strategy and innovation planning: scenario technique...

MANAGEMENT OF INNOVATION IN HEALTH CARE AT THE REGIONAL LEVEL

Directory of Open Access Journals (Sweden)

Ye. G. Totskaya

2014-01-01

Full Text Available The paper reviews topical issues of organization and management of innovative activity in the regional health care system.Objective. Development and scientific substantiation of a conceptual model of managing innovation in the regional health care system, introduction of institutional mechanisms for its implementation, and evaluation of their efficacy in using diagnosis and treatment technologies. Objectives of the study included reviewing the organization status and problems hampering the development, identification of prospects, and justification for appropriate changes in innovation in healthcare system and medical science at the regional level.Material and methods. To conduct a comprehensive assessment of the status and meet challenges of innovation promotion, a methodology for social-hygienic research was worked out including bibliographic and analytical methods, situational analysis, sociological and economic methods, expert assessment, methods for quality management system audit in accordance with ISO 19011:2002, IDEFO function modeling (RD IDEF0-2000, and organizational modeling. The study was based on the analysis of foreign and domestic literature, statistics, methods for managerial modeling, as well as management experience (including innovative methodological approaches gained by Novosibirsk Research Institute of Traumatology and Orthopedics named after Ya.L. Tsivyan which meets the requirements for a platform for research and innovative product reproduction, including research, clinical, organizational, and managerial aspects. Other facilities were considered in conjunction with the leading innovative platform.Results. The paper presents a scientifically based model of innovative medical environment with its elements as subjects, each with a set of functions. Conceptual model for management includes structuring (resource, processes, and quality management; application of international standards and strategic management mechanisms

Workplace innovation, social innovation and social quality

NARCIS (Netherlands)

Oeij, P.R.A.; Dhondt, S.; Korver, T.

2011-01-01

Social innovation is becoming a core value of the EU flagship initiative Innovation Union, but it is not clearly demarcated as it covers a wide field of topics. To understand social innovation within European policymaking a brief outline is given of EC policy developments on innovation and on

Study on methods of quantitative analysis of the biological thin samples in EM X-ray microanalysis

International Nuclear Information System (INIS)

Zhang Detian; Zhang Xuemin; He Kun; Yang Yi; Zhang Sa; Wang Baozhen

2000-01-01

Objective: To study the methods of quantitative analysis of the biological thin samples. Methods: Hall theory was used to study the qualitative analysis, background subtraction, peel off overlap peaks; external radiation and aberrance of spectra. Results: The results of reliable qualitative analysis and precise quantitative analysis were achieved. Conclusion: The methods for analysis of the biological thin samples in EM X-ray microanalysis can be used in biomedical research

Numerical study of water diffusion in biological tissues using an improved finite difference method

International Nuclear Information System (INIS)

Xu Junzhong; Does, Mark D; Gore, John C

2007-01-01

An improved finite difference (FD) method has been developed in order to calculate the behaviour of the nuclear magnetic resonance signal variations caused by water diffusion in biological tissues more accurately and efficiently. The algorithm converts the conventional image-based finite difference method into a convenient matrix-based approach and includes a revised periodic boundary condition which eliminates the edge effects caused by artificial boundaries in conventional FD methods. Simulated results for some modelled tissues are consistent with analytical solutions for commonly used diffusion-weighted pulse sequences, whereas the improved FD method shows improved efficiency and accuracy. A tightly coupled parallel computing approach was also developed to implement the FD methods to enable large-scale simulations of realistic biological tissues. The potential applications of the improved FD method for understanding diffusion in tissues are also discussed. (note)

Contribution to pressure vessels design of innovative methods and comparative application with standardized rules on a realistic structure – Part I

International Nuclear Information System (INIS)

Rohart, Philippe; Panier, Stéphane; Hariri, Saïd; Simonet, Yves; Afzali, Mansour

2015-01-01

Design of pressure vessels, which are subjected to various natures of loading, must prevent damage mechanisms occurrence. For a load applied or maintained with a given intensity, primary failure modes can appear, such as gross plastic deformation, plastic instability or buckling. For design-by-analysis, the reference methodology is based on an elastic stress calculation. During the last decade, studies have shown that this ingenious procedure could provide conservative design limits. They can become actually overly conservative in a context of increasing complexity of geometry and loading modelling. In parallel, technological and theoretical developments enabled limit analysis to be considered as an interesting design methodology. This is suggested in standards and codes (EN 13445, CODAP, Boiler and Pressure Vessels Code) since the early 2000"'"s. In this first of two companion papers, a set of standardized and innovative procedures is introduced. These approaches rely on various concepts, such as elasticity, incremental elastoplasticity, or elastic compensation (Modified Elastic Compensation Method, Linear Matching Method). Each methodology is presented on theoretical aspects, eventually adapted so as to take into account safety margins. They are then applied on a model inspired from a real industrial reactor, using Abaqus. Results are compared to reference data from codes, in terms of accuracy and computing time. A final assessment underlines practical benefits that could be expected. - Highlights: • A review of pressure vessels design methods against gross plastic deformation is made. • Innovative methodologies are introduced in order to overcome practical limits of classical methods. • Comparative tests are performed on one Benchmark with both classical and innovative procedures. • Results show the ability of innovative methodologies to improve the ratio ‘accuracy’ – ‘computationnal time’.

Application of radiochemical methods for development of new biological preparation designed for soil bioremediation

International Nuclear Information System (INIS)

Kim, A.A.; Djuraeva, G.T.; Djumaniyazova, G.I.; Yadgarov, Kh.T.

2006-01-01

Full text: Internationally the bioremediation of agricultural lands contaminated by persistent chloroorganic compounds by means of the microbial methods are used as the most low-cost and the most effective. One of the factors reducing efficacy of microbial degradation, is often the low quantity of microorganisms - destructors in the soil. Therefore, we have designed bioremediation technology of soils, contaminated by organochlorine compounds, with use of the alive microorganisms as active agent. We developed the biological preparation containing 5 aboriginal active strains of bacteria - destructors of persistent chloroorganic compounds and investigated the ability of biological preparation to increase the bioremediation potential of contaminated soils. To carry out the investigation we developed the complex of radiochemical methods with use of tritium labeled PCBs, including the following methods: 1.The method to define the accumulation and degradation of PCBs in soil bacteria in culture allows determination of quantitative characteristics of bacterial strains. 2. The method to define the PCBs degradation by soil bacteria strains in model conditions in the soil allows to estimate the PCB-destructive activity of strains after introducing in soil. 3. A method to define the PCB-destructive activity of own microbiota of contaminated soil. 4. A method to define the effect of stimulation of the PCB-destructive activity of biological preparation and own microbiota of soil with the help of biofertilizers. By using the developed radiochemical methods we have carried out investigation on creation of new biological preparation on the basis of strains of soil bacteria - destructors of PCBs. We also determined the quality and quantity characteristics of HCCH and PCBs-destructive activity of new biological preparation. It is shown that the new biological preparation is capable of accumulation and destruction of the PCBs in culture and in soil at model conditions. Thus, the

A living foundry for Synthetic Biological Materials: A synthetic biology roadmap to new advanced materials.

Science.gov (United States)

Le Feuvre, Rosalind A; Scrutton, Nigel S

2018-06-01

Society is on the cusp of harnessing recent advances in synthetic biology to discover new bio-based products and routes to their affordable and sustainable manufacture. This is no more evident than in the discovery and manufacture of Synthetic Biological Materials , where synthetic biology has the capacity to usher in a new Materials from Biology era that will revolutionise the discovery and manufacture of innovative synthetic biological materials. These will encompass novel, smart, functionalised and hybrid materials for diverse applications whose discovery and routes to bio-production will be stimulated by the fusion of new technologies positioned across physical, digital and biological spheres. This article, which developed from an international workshop held in Manchester, United Kingdom, in 2017 [1], sets out to identify opportunities in the new materials from biology era. It considers requirements, early understanding and foresight of the challenges faced in delivering a Discovery to Manufacturing Pipeline for synthetic biological materials using synthetic biology approaches. This challenge spans the complete production cycle from intelligent and predictive design, fabrication, evaluation and production of synthetic biological materials to new ways of bringing these products to market. Pathway opportunities are identified that will help foster expertise sharing and infrastructure development to accelerate the delivery of a new generation of synthetic biological materials and the leveraging of existing investments in synthetic biology and advanced materials research to achieve this goal.

Moving the innovation horizon in Asia

NARCIS (Netherlands)

Huizingh, Eelko K.R.E.

2017-01-01

Innovation is responding to or anticipating change by creating new value. Firms constantly face changes and the need to adapt. This is nothing new and has been true for centuries, what is changing are the context and means by which firms respond. As a result, innovation management methods need to be

SPECIFICS OF ELABORATING METHODOLOGY TO TEACH INNOVATIVE COMPETENCE USING EMBEDDABLE MODULE

Directory of Open Access Journals (Sweden)

Nikolai I. Naumkin

2016-12-01

Full Text Available Introduction: the article is concerned with the development of competence when teaching students innovative activity. The analysis of bachelor’s degree programmes in engineering and technology demonstrates the absence of competencies for innovation training. The curricula of the Russian universities do not contain any academic disciplines for teaching innovation as well as there is no definition of “engineering activities”, and “innovation”. Nethertheless the qualification requirements describe some separate components such as R&D, implementation and use of technical and technological innovations implying management of intellectual activity and its results for all occupations, hence mandatory training of bachelor degree students in innovative activities. Materials and Methods: the authors used: a theoretical methods: analysis of philosophical, scientific, technical, engineering, psychological and educational literature; analysis and extrapolation of the research results and teaching experience; modeling of pedagogical situations, analysis of educational standards, foreign and domestic programs of technical training, textbooks and manuals; b scientific methods: generalization, classification, ordering, compare, comparison, modeling; c methods of special research: a system-element method, system-structural and system-functional analysis of the training content, analysis and generalization of pedagogical experience in teaching courses at universities; d experimental and psychology diagnostic methods. Results: the authors developed and implemented the method of teaching engineering students innovative activities based on adding flexible module to core curriculum, a case study of the National Research Mordovia State University. Discussion and Conclusions: the results of the research underscore the significance of the innovation competence by including innovative training module into structure of technical disciplines, as well as specify the

Innovation

Science.gov (United States)

EPA frames innovation as critical to the protection of human health and the environment through initiatives such as sustainable practices, innovative research, prize competitions, innovation awards, partnerships, and community activities.

Highly Adaptable but Not Invulnerable: Necessary and Facilitating Conditions for Research in Evolutionary Developmental Biology

NARCIS (Netherlands)

Laudel, Grit; Benninghoff, Martin; Lettkemann, Eric; Håkansson, Elias; Whitley, Richard; Gläser, Jochen

2014-01-01

Evolutionary developmental biology is a highly variable scientific innovation because researchers can adapt their involvement in the innovation to the opportunities provided by their environment. On the basis of comparative case studies in four countries, we link epistemic properties of research

Chosen aspects of innovative projects management

Directory of Open Access Journals (Sweden)

J. Gawlik

2010-07-01

Full Text Available Any company willing to maintain its market position has to search and implement innovative products and services. Integrated development ofenterprise’s innovative activity requests a constant search for new technologies and new organizational forms. Ability of effectivemanagement of innovative projects becomes a crucial issue. The paper presents a characteristic of innovative projects accordingly toOECD standards. Project management concepts based on Project Management Institute (PMI and International Project ManagementAssociation (IPMA procedures have been discussed. Key success factors have been defined, i.e.: obtaining assumed project outcome (range, project implementation conform to planned schedule (deadline, maintaining project costs under a certain limit (budget, quality (are the customers satisfied?, resources (team losses and interpersonal relations. Tables comparing product innovativeness with fields of requested know – how for particular product innovativeness levels have been elaborated. Finally, SCRUM method of adaptive project management aiming at providing possibly optimal outcome has been described.

Challenges to Value-Enhancing Innovation in Health Care Delivery: Commonalities and Contrasts with Innovation in Drugs and Devices.

Science.gov (United States)

Garber, Steven; Gates, Susan M; Blume-Kohout, Margaret E; Burgdorf, James R; Wu, Helen

2012-01-01

Limiting the growth of health care costs while improving population health is perhaps the most important and difficult challenge facing U.S. health policymakers. The role of innovation in advancing these social goals is controversial, with many seeing innovation as a major cause of cost growth and many others viewing innovation as crucial for improving the quality of care and health outcomes. The authors argue that mitigating the tension between improving health and controlling costs requires more-nuanced perspectives on innovation. More specifically, they argue that policymakers should carefully distinguish between innovative activities that are worth their social costs and activities that are not worth their social costs and try to encourage the former and discourage the latter. The article considers innovation in drugs, devices, and methods of delivering health care, with particular attention to delivery.

An Innovative Oil Pollution Containment Method for Ship Wrecks Proposed for Offshore Well Blow-outs

OpenAIRE

ANDRITSOS Fivos; COJINS Hans

2011-01-01

In the aftermath of the PRESTIGE disaster, an innovative system for the prompt intervention on oil pollution sources (primarily ship wrecks) at great depths was conceived at the Joint Research Center of the European Commission. This system, with some re-engineering, could also serve for collecting oil and gas leaking after an offshore well blow-out and could constitute a reference method for prompt intervention on deep water oil pollution sources like ship wrecks and blown-out offshore wells....

Innovative economy in the Baltic Sea region

Directory of Open Access Journals (Sweden)

Mezhevich Nikolay

2012-03-01

Full Text Available Innovative activity is carried out at three levels — those of the state, region and a company or a university. This article considers the level of development of knowledge-based economy in Germany, Denmark, Sweden, Finland, Estonia, Latvia, Lithuania, and Poland at each of the three levels, as well as descripes the spatial differentiation of innovative activity within the Baltic region. The analysis is done on the basis of national and international research, as well as statistical data on the intensity of research and development, structure of research expenditure, human capital in the field of advanced technologies, and the methods of institutional support for innovative activity. The authors characterise the role of business, university, and authorities — which constitute the «triple helix» — in national innovative systems. The article also analyses such important factors as the intensity of research and development, the share of employees in the field of advanced technologies, and the methods of public support. Examples of private-public infrastructure for the implementation of innovative projects are offered.

National innovation system of Russia: state of the art and prospects of development

Directory of Open Access Journals (Sweden)

Viktoriya K. Makhortova

2014-01-01

Full Text Available Objective to characterize the national innovative system of Russia to identify its main features opportunities threats strengths and weaknesses the causes for the lag in innovation to formulate development priorities as well as the key principles for improving the national innovation system of Russia. Methods in this work were applied scientific methods of cognition generalization of the logical method analysis method of economic analysis method of expert estimations. Results SWOT analysis is compiled for the national innovation system of Russia its characteristic features and peculiarities are determined. The necessity of optimization and improvement of construction principles of the national innovation system of Russia is proved. Recommendations are given. Scientific novelty new recommendations for state innovation management are given and the existing ones are improved. In addition the proposed list of principles is grouped by significance. Practical value the possibility to optimize measures of the state innovation management in Russia to accelerate its exit from unsustainable status in this field and to strengthen the growth of innovative development.

Chemical biology based on target-selective degradation of proteins and carbohydrates using light-activatable organic molecules.

Science.gov (United States)

Toshima, Kazunobu

2013-05-01

Proteins and carbohydrates play crucial roles in a wide range of biological processes, including serious diseases. The development of novel and innovative methods for selective control of specific proteins and carbohydrates functions has attracted much attention in the field of chemical biology. In this account article, the development of novel chemical tools, which can degrade target proteins and carbohydrates by irradiation with a specific wavelength of light under mild conditions without any additives, is introduced. This novel class of photochemical agents promise bright prospects for finding not only molecular-targeted bioprobes for understanding of the structure-activity relationships of proteins and carbohydrates but also novel therapeutic drugs targeting proteins and carbohydrates.

Chemical Pretreatment Methods for the Production of Cellulosic Ethanol: Technologies and Innovations

Directory of Open Access Journals (Sweden)

Edem Cudjoe Bensah

2013-01-01

Full Text Available Pretreatment of lignocellulose has received considerable research globally due to its influence on the technical, economic and environmental sustainability of cellulosic ethanol production. Some of the most promising pretreatment methods require the application of chemicals such as acids, alkali, salts, oxidants, and solvents. Thus, advances in research have enabled the development and integration of chemical-based pretreatment into proprietary ethanol production technologies in several pilot and demonstration plants globally, with potential to scale-up to commercial levels. This paper reviews known and emerging chemical pretreatment methods, highlighting recent findings and process innovations developed to offset inherent challenges via a range of interventions, notably, the combination of chemical pretreatment with other methods to improve carbohydrate preservation, reduce formation of degradation products, achieve high sugar yields at mild reaction conditions, reduce solvent loads and enzyme dose, reduce waste generation, and improve recovery of biomass components in pure forms. The use of chemicals such as ionic liquids, NMMO, and sulphite are promising once challenges in solvent recovery are overcome. For developing countries, alkali-based methods are relatively easy to deploy in decentralized, low-tech systems owing to advantages such as the requirement of simple reactors and the ease of operation.

Innovation and the growth of human population.

Science.gov (United States)

Weinberger, V P; Quiñinao, C; Marquet, P A

2017-12-05

Biodiversity is sustained by and is essential to the services that ecosystems provide. Different species would use these services in different ways, or adaptive strategies, which are sustained in time by continuous innovations. Using this framework, we postulate a model for a biological species ( Homo sapiens ) in a finite world where innovations, aimed at increasing the flux of ecosystem services (a measure of habitat quality), increase with population size, and have positive effects on the generation of new innovations (positive feedback) as well as costs in terms of negatively affecting the provision of ecosystem services. We applied this model to human populations, where technological innovations are driven by cumulative cultural evolution. Our model shows that depending on the net impact of a technology on the provision of ecosystem services ( θ ), and the strength of technological feedback ( ξ ), different regimes can result. Among them, the human population can fill the entire planet while maximizing their well-being, but not exhaust ecosystem services. However, this outcome requires positive or green technologies that increase the provision of ecosystem services with few negative externalities or environmental costs, and that have a strong positive feedback in generating new technologies of the same kind. If the feedback is small, then the technological stock can collapse together with the human population. Scenarios where technological innovations generate net negative impacts may be associated with a limited technological stock as well as a limited human population at equilibrium and the potential for collapse. The only way to fill the planet with humans under this scenario of negative technologies is by reducing the technological stock to a minimum. Otherwise, the only feasible equilibrium is associated with population collapse. Our model points out that technological innovations per se may not help humans to grow and dominate the planet. Instead

Application of photonuclear methods of analysis in biology, medicine, ecological studies

International Nuclear Information System (INIS)

Burmistenko, Yu.N.

1986-01-01

Examples of application of photonuclear methods of analysis (PhMA) of the substance composition in biology, medicine, ecology are considered. The methods for determining the element composition of soft and bone tissues, blood, urine are developed. The results of studying the limits of determination of different elements are presented. In ecological investigations PhMA is applied for studying the composition of atmospheric aerosols, industrial sewage, canalization wastes, pollution of soil, plants, animals with toxic elements

A systematic design method for robust synthetic biology to satisfy design specifications.

Science.gov (United States)

Chen, Bor-Sen; Wu, Chih-Hung

2009-06-30

Synthetic biology is foreseen to have important applications in biotechnology and medicine, and is expected to contribute significantly to a better understanding of the functioning of complex biological systems. However, the development of synthetic gene networks is still difficult and most newly created gene networks are non-functioning due to intrinsic parameter uncertainties, external disturbances and functional variations of intra- and extra-cellular environments. The design method for a robust synthetic gene network that works properly in a host cell under these intrinsic parameter uncertainties and external disturbances is the most important topic in synthetic biology. In this study, we propose a stochastic model that includes parameter fluctuations and external disturbances to mimic the dynamic behaviors of a synthetic gene network in the host cell. Then, based on this stochastic model, four design specifications are introduced to guarantee that a synthetic gene network can achieve its desired steady state behavior in spite of parameter fluctuations, external disturbances and functional variations in the host cell. We propose a systematic method to select a set of appropriate design parameters for a synthetic gene network that will satisfy these design specifications so that the intrinsic parameter fluctuations can be tolerated, the external disturbances can be efficiently filtered, and most importantly, the desired steady states can be achieved. Thus the synthetic gene network can work properly in a host cell under intrinsic parameter uncertainties, external disturbances and functional variations. Finally, a design procedure for the robust synthetic gene network is developed and a design example is given in silico to confirm the performance of the proposed method. Based on four design specifications, a systematic design procedure is developed for designers to engineer a robust synthetic biology network that can achieve its desired steady state behavior

An independent accurate reference method for the determination of chromium in biological materials

NARCIS (Netherlands)

Lagerwaard, A.; Woittiez, J.R.W.; de Goeij, J.J.M.

1994-01-01

A method for the determination of Cr in biological materials with high accuracy is reported for use as an independent reference method. It is based on radiochemical neutron activation analysis (RNAA) in combination with an individual yield determination based on the online yield principle. A

INNOVATIVE USE OF QUALITY MANAGEMENT METHODS FOR PRODUCT IMPROVEMENT

Directory of Open Access Journals (Sweden)

Katarzyna MIDOR

2016-10-01

Full Text Available Organisations constantly look for new, innovative solutions and methods which could be used to improve their efficiency and increase the quality of their products. Identifying the causes for returns is an important issue for modern compa-nies, as returns are the cause for the increase in production costs and, most importantly, the loss of credibility in the eyes of the client. Therefore, for the company to be able to sustain or strengthen its position on the market, it has to follow the rules of quality management. Especially important is the rule of constant improvement. This rule is primarily connected with preventing errors and defects from occurring at all the stages of the production process. To achieve that, one must, among other things, use quality management tools. The article presents an analysis of causes for returns of a vibrating screen produced by a company which manufactures machinery and equipment for the extractive industry, using quality management tools such as the Ishikawa diagram and Pareto analysis. The analysis allowed for the identifi-cation of the causes of client returns which could not be previously identified, and proposing solutions for them.

Innovative Use of Quality Management Methods for Product Improvement

Science.gov (United States)

Midor, Katarzyna; Žarnovský, Jozef

2016-12-01

Organisations constantly look for new, innovative solutions and methods which could be used to improve their efficiency and increase the quality of their products. Identifying the causes for returns is an important issue for modern companies, as returns are the cause for the increase in production costs and, most importantly, the loss of credibility in the eyes of the client. Therefore, for the company to be able to sustain or strengthen its position on the market, it has to follow the rules of quality management. Especially important is the rule of constant improvement. This rule is primarily connected with preventing errors and defects from occurring at all the stages of the production process. To achieve that, one must, among other things, use quality management tools. The article presents an analysis of causes for returns of a vibrating screen produced by a company which manufactures machinery and equipment for the extractive industry, using quality management tools such as the Ishikawa diagram and Pareto analysis. The analysis allowed for the identification of the causes of client returns which could not be previously identified, and proposing solutions for them.

A living foundry for Synthetic Biological Materials: A synthetic biology roadmap to new advanced materials

Directory of Open Access Journals (Sweden)

Rosalind A. Le Feuvre

2018-06-01

Full Text Available Society is on the cusp of harnessing recent advances in synthetic biology to discover new bio-based products and routes to their affordable and sustainable manufacture. This is no more evident than in the discovery and manufacture of Synthetic Biological Materials, where synthetic biology has the capacity to usher in a new Materials from Biology era that will revolutionise the discovery and manufacture of innovative synthetic biological materials. These will encompass novel, smart, functionalised and hybrid materials for diverse applications whose discovery and routes to bio-production will be stimulated by the fusion of new technologies positioned across physical, digital and biological spheres. This article, which developed from an international workshop held in Manchester, United Kingdom, in 2017 [1], sets out to identify opportunities in the new materials from biology era. It considers requirements, early understanding and foresight of the challenges faced in delivering a Discovery to Manufacturing Pipeline for synthetic biological materials using synthetic biology approaches. This challenge spans the complete production cycle from intelligent and predictive design, fabrication, evaluation and production of synthetic biological materials to new ways of bringing these products to market. Pathway opportunities are identified that will help foster expertise sharing and infrastructure development to accelerate the delivery of a new generation of synthetic biological materials and the leveraging of existing investments in synthetic biology and advanced materials research to achieve this goal. Keywords: Synthetic biology, Materials, Biological materials, Biomaterials, Advanced materials

Anti-friction performance of FeS nanoparticle synthesized by biological method

Energy Technology Data Exchange (ETDEWEB)

Zhou, Lu Hai, E-mail: lhzhou@t.shu.edu.cn [School of Materials Science and Engineering, Shanghai University, Shanghai 200444 (China); Wei, Xi Cheng [School of Materials Science and Engineering, Shanghai University, Shanghai 200444 (China); Ma, Zi Jian [Pipe and Bar Division of Baoshan Iron & Steel Co., Ltd., Shanghai 200941 (China); Mei, Bin [Shanghai Medical Instrumentation College, Shanghai 200093 (China)

2017-06-15

Highlights: • FeS nanoparticles were successfully prepared by a biological method. • The anti-friction performance of prepared nanoparticle under oil lubricating and dry condition were analyzed. • The anti-friction mechanism of FeS nanoparticle was discussed. - Abstract: FeS nanoparticle is prepared by a biological method. The size, morphology and structure of the FeS nanoparticle are characterized by the means of X-ray diffraction and transmission electron microscopy. The anti-friction behavior of the FeS nanoparticle as a lubricating oil additive is evaluated in the engine oil by using a face-to-face contact mode. The worn surface is characterized by using the scanning electron microscopy and secondary ion mass spectroscopy in order to find the reasons resulting in the reduction of friction coefficient due to the addition of the FeS nanoparticle. The anti-friction mechanism of the FeS nanoparticle is elucidated based on the experimental results.

Innovative Mobile Smart Photonic Dimensional, Color and Spectral Measurement Engineering

Science.gov (United States)

Hofmann, Dr Dietrich, Prof; Dittrich (B. Eng. , Paul-Gerald; Höfner (B. Eng. , Dieter; Kraus, Daniel

2015-02-01

Aim of the paper is the demonstration of a paradigm shift in dimensional, color and spectral measurements in industry, biology/medicine, farming/environmental protection and security, as well as in education and training: Measurement engineering and quality assurance become mobile, modular and smart. Smartpads, smartphones and smartwatches (smartcomps) in combination with innovative hardware apps (hwapps) and conventional software apps (swapps) are fundamental enablers for the transformation from conventional stationary working places towards innovative mobile working places with in-field measurements and point-of-care (POC) diagnostics. Furthermore mobile open online courses (MOOCs) are transforming the study habits. Practical examples for the application of innovative photonic micro dimensiometers, colorimeters and spectrometers will be given. The innovative approach opens so far untapped enormous markets for measurement science, engineering, applications, education and training. These innovative working conditions will be fast accepted due to their convenience, reliability and affordability. A highly visible advantage of smartcomps is the huge number of their real distribution, their worldwide connectivity via Internet and cloud services, the standardized interfaces like USB and HDMI and the experienced capabilities of their users for practical operations, obtained with their private smartcomps.

Innovative Mobile Smart Photonic Dimensional, Color and Spectral Measurement Engineering

International Nuclear Information System (INIS)

Hofmann, Dietrich; Dittrich, Paul-Gerald; Höfner, Dieter; Kraus, Daniel

2015-01-01

Aim of the paper is the demonstration of a paradigm shift in dimensional, color and spectral measurements in industry, biology/medicine, farming/environmental protection and security, as well as in education and training: Measurement engineering and quality assurance become mobile, modular and smart. Smartpads, smartphones and smartwatches (smartcomps) in combination with innovative hardware apps (hwapps) and conventional software apps (swapps) are fundamental enablers for the transformation from conventional stationary working places towards innovative mobile working places with in-field measurements and point-of-care (POC) diagnostics. Furthermore mobile open online courses (MOOCs) are transforming the study habits. Practical examples for the application of innovative photonic micro dimensiometers, colorimeters and spectrometers will be given. The innovative approach opens so far untapped enormous markets for measurement science, engineering, applications, education and training. These innovative working conditions will be fast accepted due to their convenience, reliability and affordability. A highly visible advantage of smartcomps is the huge number of their real distribution, their worldwide connectivity via Internet and cloud services, the standardized interfaces like USB and HDMI and the experienced capabilities of their users for practical operations, obtained with their private smartcomps

Creativity and Innovation Encouraged in Hospital X

Directory of Open Access Journals (Sweden)

Mateja Bogovič

2014-02-01

Full Text Available Research Question (RQ: Are creativity and innovation encouraged in Hospital X? Does satisfaction of employees at the workplace depend on the length of their employment? Does employee satisfaction depend on innovation? Purpose: It is important that creativity and innovation of employees are noticed in Hospital X in a timely manner. Various approaches can be used to motivate their creative thinking (using different professional factors. Method: Qualitative method, questionnaire with 8 questions and processing of results with χ2 test and frequency distribution. Results: The results of the research showed that 60% of employees at Hospital X were encouraged to be creative and innovative, whereas satisfaction at the workplace in connection with the period of employment did not have an effect on their satisfaction within the organization. Organization: The research results will give the management a clearer idea of employees’ opinions concerning their creativity and innovation. Society: Opinion of workers in a certain organization can encourage other organizations to be more creative and innovative. Originality: It is a small organization and results of the research refer to its originality. Limitations/Future Research: The limitation of this study was with regard to time and for this reason data collection was carried out only in the surgical unit of Hospital X.

Biomedical device innovation methodology: applications in biophotonics

Science.gov (United States)

Beswick, Daniel M.; Kaushik, Arjun; Beinart, Dylan; McGarry, Sarah; Yew, Ming Khoon; Kennedy, Brendan F.; Maria, Peter Luke Santa

2018-02-01

The process of medical device innovation involves an iterative method that focuses on designing innovative, device-oriented solutions that address unmet clinical needs. This process has been applied to the field of biophotonics with many notable successes. Device innovation begins with identifying an unmet clinical need and evaluating this need through a variety of lenses, including currently existing solutions for the need, stakeholders who are interested in the need, and the market that will support an innovative solution. Only once the clinical need is understood in detail can the invention process begin. The ideation phase often involves multiple levels of brainstorming and prototyping with the aim of addressing technical and clinical questions early and in a cost-efficient manner. Once potential solutions are found, they are tested against a number of known translational factors, including intellectual property, regulatory, and reimbursement landscapes. Only when the solution matches the clinical need, the next phase of building a "to market" strategy should begin. Most aspects of the innovation process can be conducted relatively quickly and without significant capital expense. This white paper focuses on key points of the medical device innovation method and how the field of biophotonics has been applied within this framework to generate clinical and commercial success.

Innovative learning for innovation

NARCIS (Netherlands)

Dr.Ir. Hay Geraedts

2010-01-01

Introduction Innovation is crucial for companies who have to react to constantly changing markets. Several national and European research institutes stress the importance of developing innovation for small and medium size enterprises (SMEs). This was a trigger to design a minor on strategic

Strategies for multi-disciplinary science innovation education

NARCIS (Netherlands)

Proveniers, A.; Westra, J.; Chova, L.G.; Belenguer, D.M.; Torres, I.C.

2010-01-01

Almost by definition, innovative, sustainable economics, technologies, derived services and products have to be developed in a multi-disciplinary way: all kinds of bits and parts from less sustainable methods, technologies, services and products have to be reshuffled in new innovative, sustainable

Biological eleimination of nitrogen and phosphorus: Field results and modelling aspects. Rimozione biologica di azoto e fosforo: Risultati su scala reale ed aspetti modellistici

Energy Technology Data Exchange (ETDEWEB)

Malpei, F.; Andreattola, G.; Canziani, R. (Politecnico di Milano, Milan (Italy))

1992-07-01

The processes described in this article can be easily adapted to existing biological activated sludge plants which eliminate nitrogen and provide for considerable savings with respect to traditional chemical precipitation methods, as well as the disposal of exhausted sludge. This article assesses this innovative combined nitrogen and the removal efficiencies of phosphorus removal method by analyzing the basic process schemes and real plant and simulated operating results.

Branching innovation, recombinant innovation, and endogenous technological transitions

NARCIS (Netherlands)

Frenken, K.; Izquierdo, L.; Zeppini, P.

2012-01-01

We propose a model of technological transitions based on two different types of innovations. Branching innovations refer to technological improvements along a particular path, while recombinant innovations represent fusions of multiple paths. Recombinant innovations create "short-cuts" which reduce

Impact of rewarding innovation and creativity of employees

Directory of Open Access Journals (Sweden)

Polona Sladič

2016-08-01

Full Text Available Purpose and Originality: It is important that the organization establish a way of rewarding that largely encourages employees to be innovative. Is it a way of rewarding depends on the sex, marital status and education? Is it a cash prize greatest incentive for employees to innovate? Method: Qualitative method, a questionnaire, which will include 12 questions and results processing with a frequency distribution. Results: The results of the study showed that the method of remuneration depends on the sex, marital status and the level of education, while we can not state with certainty that the prize money the best motivation for innovation and creativity. Society: Opinion employees can change the way reward for innovation within organizations, thereby helping the organization to greater competitiveness. Employees are more satisfied and productivity increases. Limitations/Future Research: The study was conducted in only two organizations and should be carried out even in a few others.

The interaction between innovation and job satisfaction

OpenAIRE

Grečnaitė, Lina

2017-01-01

43 pages, 6 pictures, 4 charts, 2 table, 33 references. The main purpose of this Bachelor thesis is to identify methods which increase job satisfaction in organization of innovation creation The work consists of three main parts; the analysis of literature, the research and its results, conclusions and recommendations. Literature analysis reviews the innovation and job satisfaction theories, innovation opportunities, and how to achieve the intended result. Also, discusses the theoretical mode...

Leadership as a determinant of innovative behaviour

OpenAIRE

Jeroen de Jong; Deanne den Hartog

2003-01-01

In knowledge-intensive services innovative behaviour of co-workers is a critical success factor. In sectors like consultancy, research and architecture the nature of the work implies that projects are never alike. Innovative behaviour means that co-workers generate ideas for better and/or different products, services or working methods, and strive for implementing such changes. By carrying out certain leadership styles, entrepreneurs are able to boost innovative behaviour of their employees. ...

Traveling wave solutions of a biological reaction-convection-diffusion equation model by using $(G'/G$ expansion method

Directory of Open Access Journals (Sweden)

Shahnam Javadi

2013-07-01

Full Text Available In this paper, the $(G'/G$-expansion method is applied to solve a biological reaction-convection-diffusion model arising in mathematical biology. Exact traveling wave solutions are obtained by this method. This scheme can be applied to a wide class of nonlinear partial differential equations.

Potential of the PIGE method in the analysis of biological and mineral materials

International Nuclear Information System (INIS)

Havranek, V.

2006-01-01

A possible application of the PIGE method for the analysis of the biological and mineral samples has been tested using a 3.5 MeV Van de Graaff accelerator. The limits of detection of 4 mg/kg for fluorine, 10 mg/kg for aluminium and 200 mg/kg for phosphorus were achieved with a 3.15 MeV proton beam (8 mm in diameter, 20 nA current and 1000 s irradiation time). The PIGE method was found to be a suitable method for the determination of fluorine in the samples analyzed. With this technique, total fluorine in the sample can be quantitated without any chemical treatment. In the analysis of the phosphorus in thick biological samples, PIGE can compete with PIXE and is probably less sensitive to matrix effects and spectra fitting, which may bring about a higher accuracy of the results

Estimating the Impacts of Local Policy Innovation: The Synthetic Control Method Applied to Tropical Deforestation

Science.gov (United States)

Sills, Erin O.; Herrera, Diego; Kirkpatrick, A. Justin; Brandão, Amintas; Dickson, Rebecca; Hall, Simon; Pattanayak, Subhrendu; Shoch, David; Vedoveto, Mariana; Young, Luisa; Pfaff, Alexander

2015-01-01

Quasi-experimental methods increasingly are used to evaluate the impacts of conservation interventions by generating credible estimates of counterfactual baselines. These methods generally require large samples for statistical comparisons, presenting a challenge for evaluating innovative policies implemented within a few pioneering jurisdictions. Single jurisdictions often are studied using comparative methods, which rely on analysts’ selection of best case comparisons. The synthetic control method (SCM) offers one systematic and transparent way to select cases for comparison, from a sizeable pool, by focusing upon similarity in outcomes before the intervention. We explain SCM, then apply it to one local initiative to limit deforestation in the Brazilian Amazon. The municipality of Paragominas launched a multi-pronged local initiative in 2008 to maintain low deforestation while restoring economic production. This was a response to having been placed, due to high deforestation, on a federal “blacklist” that increased enforcement of forest regulations and restricted access to credit and output markets. The local initiative included mapping and monitoring of rural land plus promotion of economic alternatives compatible with low deforestation. The key motivation for the program may have been to reduce the costs of blacklisting. However its stated purpose was to limit deforestation, and thus we apply SCM to estimate what deforestation would have been in a (counterfactual) scenario of no local initiative. We obtain a plausible estimate, in that deforestation patterns before the intervention were similar in Paragominas and the synthetic control, which suggests that after several years, the initiative did lower deforestation (significantly below the synthetic control in 2012). This demonstrates that SCM can yield helpful land-use counterfactuals for single units, with opportunities to integrate local and expert knowledge and to test innovations and permutations on

Estimating the Impacts of Local Policy Innovation: The Synthetic Control Method Applied to Tropical Deforestation.

Science.gov (United States)

Sills, Erin O; Herrera, Diego; Kirkpatrick, A Justin; Brandão, Amintas; Dickson, Rebecca; Hall, Simon; Pattanayak, Subhrendu; Shoch, David; Vedoveto, Mariana; Young, Luisa; Pfaff, Alexander

2015-01-01

Quasi-experimental methods increasingly are used to evaluate the impacts of conservation interventions by generating credible estimates of counterfactual baselines. These methods generally require large samples for statistical comparisons, presenting a challenge for evaluating innovative policies implemented within a few pioneering jurisdictions. Single jurisdictions often are studied using comparative methods, which rely on analysts' selection of best case comparisons. The synthetic control method (SCM) offers one systematic and transparent way to select cases for comparison, from a sizeable pool, by focusing upon similarity in outcomes before the intervention. We explain SCM, then apply it to one local initiative to limit deforestation in the Brazilian Amazon. The municipality of Paragominas launched a multi-pronged local initiative in 2008 to maintain low deforestation while restoring economic production. This was a response to having been placed, due to high deforestation, on a federal "blacklist" that increased enforcement of forest regulations and restricted access to credit and output markets. The local initiative included mapping and monitoring of rural land plus promotion of economic alternatives compatible with low deforestation. The key motivation for the program may have been to reduce the costs of blacklisting. However its stated purpose was to limit deforestation, and thus we apply SCM to estimate what deforestation would have been in a (counterfactual) scenario of no local initiative. We obtain a plausible estimate, in that deforestation patterns before the intervention were similar in Paragominas and the synthetic control, which suggests that after several years, the initiative did lower deforestation (significantly below the synthetic control in 2012). This demonstrates that SCM can yield helpful land-use counterfactuals for single units, with opportunities to integrate local and expert knowledge and to test innovations and permutations on policies

Estimating the Impacts of Local Policy Innovation: The Synthetic Control Method Applied to Tropical Deforestation.

Directory of Open Access Journals (Sweden)

Erin O Sills

Full Text Available Quasi-experimental methods increasingly are used to evaluate the impacts of conservation interventions by generating credible estimates of counterfactual baselines. These methods generally require large samples for statistical comparisons, presenting a challenge for evaluating innovative policies implemented within a few pioneering jurisdictions. Single jurisdictions often are studied using comparative methods, which rely on analysts' selection of best case comparisons. The synthetic control method (SCM offers one systematic and transparent way to select cases for comparison, from a sizeable pool, by focusing upon similarity in outcomes before the intervention. We explain SCM, then apply it to one local initiative to limit deforestation in the Brazilian Amazon. The municipality of Paragominas launched a multi-pronged local initiative in 2008 to maintain low deforestation while restoring economic production. This was a response to having been placed, due to high deforestation, on a federal "blacklist" that increased enforcement of forest regulations and restricted access to credit and output markets. The local initiative included mapping and monitoring of rural land plus promotion of economic alternatives compatible with low deforestation. The key motivation for the program may have been to reduce the costs of blacklisting. However its stated purpose was to limit deforestation, and thus we apply SCM to estimate what deforestation would have been in a (counterfactual scenario of no local initiative. We obtain a plausible estimate, in that deforestation patterns before the intervention were similar in Paragominas and the synthetic control, which suggests that after several years, the initiative did lower deforestation (significantly below the synthetic control in 2012. This demonstrates that SCM can yield helpful land-use counterfactuals for single units, with opportunities to integrate local and expert knowledge and to test innovations and

Strategic Management of Innovations at Pharmaceutical Enterprises

Directory of Open Access Journals (Sweden)

Honcharova Svіtlana Yu.

2014-01-01

Full Text Available The article is devoted to theoretical and practical issues of the use of the concept of strategic management of innovations at pharmaceutical enterprises. It studies main barriers, which restrict development of Ukrainian pharmaceutical enterprises. It analyses the state and tendencies of development of innovation activity of pharmaceutical enterprises and studies foreign experience of innovation activity. It marks out specific features of strategic management of innovation development in pharmaceutical industry. It specifies the role and advantages of methods of strategic analysis in the system of management of a pharmaceutical enterprise. It considers the essence of “innovation development” and “innovation model of development” notions and analyses their organisational and legal provision. It justifies strategic tasks of the pharmaceutical filed to focus on in order to achieve a breakthrough when building an innovation model of economic development. The article proves that the most important factors that ensure growth of efficiency of pharmaceutical production are: wide application of the concept of strategic management and creation of innovations.

FUTURE TEACHERS TRAINING TO INNOVATIVE PEDAGOGICAL ACTIVITY: CONTEXT APPROACH

Directory of Open Access Journals (Sweden)

Shevchenko L.

2017-03-01

Full Text Available The innovative processes in education arose in different historical periods and determined its development. The analysis of theoretical and experimental studies showed that now the teachers have difficulty in developing and implementing innovative technologies, choosing the most appropriate pedagogical methods and assets. The widespread innovations lead to changes in future teachers’ training to the professional activity. The leading objective of higher pedagogical education is to train teacher who has the developed personal and professional skills, able to perform innovative teaching activity. The achievement of this strategic objective requires the organization of targeted training of future teachers to innovative pedagogical activity in terms of higher education system, promoting their professional and personal growth, the formation of innovative capacity and innovative culture. In this regard, there is a need to find approaches to education that are focused on the future content of professional activity. In our opinion, these requirements fully meet the contextual approach that provides consistent, continuous and systematic formation of future teachers’ readiness to innovative pedagogical activity. The this article we analyzed the features of the training of future teachers to innovative pedagogical activity; identified the possibilities of contextual education application in pedagogical institutions; considered the survey results of the beginning teachers of secondary and vocational schools; defined a number of innovative forms, methods and technologies for implementing the contextual education system thet allow combining educational, quasi professional and educational-professional activity, such as: design and usage of electronic educational resources, electronic teaching methods; engaging students into self-educational activity by means of Web services; fulfillment of individual and group projects based on Web and Blog-quests in which

Innovative configurations of electrochemical DNA biosensors (a review)

OpenAIRE

Girousi, Stella; Karastogianni, Sofia; Serpi, Constantina

2011-01-01

In the field of electrochemical biosensing, transition metal complexes achieved a significant importance as hybridization indicators or electroactive markers of DNA. Their incorporation in electro-chemical DNA biosensors enables to offer a promising perspective in understanding of the biological activity of some chemical compounds. In this context, the development of innovative configurations of electrochemical DNA biosensors applied to life sciences during the last years were reviewed ...

Comparative Analysis of Innovative Systems in the Russian Regions

Directory of Open Access Journals (Sweden)

Nadezhda Nikolaevna Mikheeva

2014-12-01

Full Text Available This article was conducted with the financial support of the Program of fundamental studies of the Presidium of the Russian Academy of Sciences No. 31, «The Role of Space in the Modernization of Russia: Natural and Socio-Economic Potential» (project 7.2 «Tools of Regional Policy and the Effectiveness of Their Use» Despite the abundance of literature on innovation in the regions, there is no frame of reference about the patterns and mechanisms of formation of regional innovation systems (RIS. So it’s next to impossible to differentiate approaches to stimulation of innovations in the regions taking into account their specific characters. Therefore, the author attempts to formalize the definition of RIS and to provide not only qualitative but also quantitative evaluation of different types of regional innovation systems. This paper is trying to find a set of models of RIS development in Russian regions with specific characters. These regional peculiarities play a key role in a process of selecting methods for further RIS development, including methods of state support of innovation, which are adequate to the characteristics of the regional innovation system. The author obtained the following results: 1 presentation of various approaches to define regional innovative systems; 2 proposition of RIS structure that includes 5 blocks (creation of innovations; production and realization of innovative goods and services in the region; innovative infrastructure of the region; demand for innovations and innovative policy and 3 development of the system of statistical indicators that characterize RIS. On the basis of formal and substantive analysis of these indicators the researcher defined 6 models of regional innovative systems prevailing in the Russian circumstances

Learning Biology through Innovative Curricula: A Comparison of Game- and Nongame-Based Approaches

Science.gov (United States)

Sadler, Troy D.; Romine, William L.; Menon, Deepika; Ferdig, Richard E.; Annetta, Leonard

2015-01-01

This study explored student learning in the context of innovative biotechnology curricula and the effects of gaming as a central element of the learning experience. The quasi-experimentally designed study compared learning outcomes between two curricular approaches: One built around a computer-based game, and the other built around a narrative…

Internal Determinants of Product Innovation and Management Innovation

OpenAIRE

Harder, Mie

2011-01-01

This paper adopts a behavioral theory of the firm perspective in order to compare the antecedents of two types of innovation: Management innovation refers to the adoption of new management practices or organizational structures, whereas product innovation refers to the introduction of new products or services on the market. The study further distinguishes between two categories of innovation within each type: new to the firm and new to the industry innovations. The findings indica...

The model of evaluation of innovative potential of enterprise

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Ганна Ігорівна Заднєпровська

2015-06-01

Full Text Available The basic components of the enterprise’s innovative potential evaluation process are investigated. It is offered the conceptual model of evaluation of the innovative potential that includes: subjects, objects, purpose, provision of information, principles, methods, criteria, indicators. It is noted that the innovative capacity characterizes the transition from the current to the strategic level of innovation potential and, thus, characterizes the composition of objects from position of user

The effect of teaching methods on cognitive achievement, retention, and attitude among in biology studying

Directory of Open Access Journals (Sweden)

Snezana Stavrova Veselinovskaa

2011-12-01

Full Text Available The purpose of this paper is to determine the effects of usage of sequential teaching method on the academic achievement and retention level of students. Three student groups of biology students in University “Goce Delcev”, Faculty of Natural and Technical Sciences, Institute of Biology, - Stip, R. Macedonia were offered a topic on general characteristics of Proteins: Their Biological Functions and Primary Structure with different sequences of 3 teaching methods. The teaching methods were Laboratory method (student experiment, slide demonstration and lecture method. The first group started to course with experiments in the laboratory, then the relevant theory of proteins was given lecture method, and then the slides was shown (Group I. The sequence of these three teaching methods used in the first group was changed in both second and third group as follow: The lecture methods, slide show and experiment in Group II, and slide show, experiment and lecture method in Group III, respectively. Laboratory method used in the study was focused on the topic of this diversity and abundance reflect the central role of proteins in virtually all aspects of cell structure and function. Achievement test contained 20 questions, testing the knowledge of facts as well as the ability to transfer the knowledge and problem solving ability. This test was used as pre-test before methods’ application, post-test after the methods’ application and retention test after 30 days from methods’ applied.

Flotation of Biological Materials

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George Z. Kyzas

2014-03-01

Full Text Available Flotation constitutes a gravity separation process, which originated from the minerals processing field. However, it has, nowadays, found several other applications, as for example in the wastewater treatment field. Concerning the necessary bubble generation method, typically dispersed-air or dissolved-air flotation was mainly used. Various types of biological materials were tested and floated efficiently, such as bacteria, fungi, yeasts, activated sludge, grape stalks, etc. Innovative processes have been studied in our Laboratory, particularly for metal ions removal, involving the initial abstraction of heavy metal ions onto a sorbent (including a biosorbent: in the first, the application of a flotation stage followed for the efficient downstream separation of metal-laden particles. The ability of microorganisms to remove metal ions from dilute aqueous solutions (as most wastewaters are is a well-known property. The second separation process, also applied effectively, was a new hybrid cell of microfiltration combined with flotation. Sustainability in this field and its significance for the chemical and process industry is commented.

Application of the evolution theory in modelling of innovation diffusion

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Krstić Milan

2016-01-01

Full Text Available The theory of evolution has found numerous analogies and applications in other scientific disciplines apart from biology. In that sense, today the so-called 'memetic-evolution' has been widely accepted. Memes represent a complex adaptable system, where one 'meme' represents an evolutional cultural element, i.e. the smallest unit of information which can be identified and used in order to explain the evolution process. Among others, the field of innovations has proved itself to be a suitable area where the theory of evolution can also be successfully applied. In this work the authors have started from the assumption that it is also possible to apply the theory of evolution in the modelling of the process of innovation diffusion. Based on the conducted theoretical research, the authors conclude that the process of innovation diffusion in the interpretation of a 'meme' is actually the process of imitation of the 'meme' of innovation. Since during the process of their replication certain 'memes' show a bigger success compared to others, that eventually leads to their natural selection. For the survival of innovation 'memes', their manifestations are of key importance in the sense of their longevity, fruitfulness and faithful replicating. The results of the conducted research have categorically confirmed the assumption of the possibility of application of the evolution theory with the innovation diffusion with the help of innovation 'memes', which opens up the perspectives for some new researches on the subject.

How Does Transformational Leadership Promote Innovation in Construction? The Mediating Role of Innovation Climate and the Multilevel Moderation Role of Project Requirements

Directory of Open Access Journals (Sweden)

Yanchun Zhang

2018-05-01

Full Text Available Innovation plays a critical role in the sustainable development of the construction industry. This research aims at examining transformational leadership’s role in shaping employees’ innovative behavior by analyzing the mediating effect of innovation climate and the cross-level moderating effect of innovativeness as a project requirement. To achieve this aim, a questionnaire survey was conducted with 300 construction industry professionals in China and 251 valid replies were received. Data collected by the questionnaire were analyzed using the method of hierarchical linear modeling (HLM. The results showed that transformational leaders could nurture a mutual climate for innovation to motivate employees’ innovative behaviors. In addition, innovativeness as a project requirement at the project level strengthens the indirect link amongst transformational leadership and innovative behavior via the innovation climate. Therefore, in the presence of higher innovativeness as a project requirement, transformational leadership is more prone to exert a positive influence upon an individual’s innovative behavior via the perceived innovation climate. The research findings improve understanding of the roles of leadership and innovation climate in affecting individual behavioral outcomes, and could help project managers and leaders encourage innovative ideas within project organizations.

Innovative presentations for dummies

CERN Document Server

Anthony, Ray

2014-01-01

Be the speaker they follow with breakthrough innovative presentations Innovative Presentations For Dummies is a practical guide to engaging your audience with superior, creative, and ultra-compelling presentations. Using clear language and a concise style, this book goes way beyond PowerPoint to enable you to reimagine, reinvent, and remake your presentations. Learn how to stimulate, capture, and hold your audience in the palm of your hand with sound, sight, and touch, and get up to speed on the latest presentation design methods that make you a speaker who gets audiences committed and acting

Graphical methods and Cold War scientific practice: the Stommel Diagram's intriguing journey from the physical to the biological environmental sciences.

Science.gov (United States)

Vance, Tiffany C; Doel, Ronald E

2010-01-01

In the last quarter of the twentieth century, an innovative three-dimensional graphical technique was introduced into biological oceanography and ecology, where it spread rapidly. Used to improve scientists' understanding of the importance of scale within oceanic ecosystems, this influential diagram addressed biological scales from phytoplankton to fish, physical scales from diurnal tides to ocean currents, and temporal scales from hours to ice ages. Yet the Stommel Diagram (named for physical oceanographer Henry Stommel, who created it in 1963) had not been devised to aid ecological investigations. Rather, Stommel intended it to help plan large-scale research programs in physical oceanography, particularly as Cold War research funding enabled a dramatic expansion of physical oceanography in the 1960s. Marine ecologists utilized the Stommel Diagram to enhance research on biological production in ocean environments, a key concern by the 1970s amid growing alarm about overfishing and ocean pollution. Before the end of the twentieth century, the diagram had become a significant tool within the discipline of ecology. Tracing the path that Stommel's graphical techniques traveled from the physical to the biological environmental sciences reveals a great deal about practices in these distinct research communities and their relative professional and institutional standings in the Cold War era. Crucial to appreciating the course of that path is an understanding of the divergent intellectual and social contexts of the physical versus the biological environmental sciences.

Workplace innovation and social innovation : an introduction

NARCIS (Netherlands)

Jürgen Howaldt; Dr. Ben Fruytier; Peter R.A. Oeij; Steven Dhondt

2016-01-01

This is the introduction to the special issue of World Review of Entrepreneurship, Management and Sustainable Development (WREMSD) dedicated to workplace innovation and social innovation related to work and organisation. As technological and business model innovations alone are not sufficient to

Workplace innovation and social innovation: an introduction

NARCIS (Netherlands)

Howaldt, J.; Oeij, P.R.A.; Dhondt, S.; Fruytier, B.

2016-01-01

This is the introduction to this special issue of World Review of Entrepreneurship, Management and Sustainable Development (WREMSD) dedicated to workplace innovation and social innovation related to work and organisation. As technological and business model innovations alone are not sufficient to

4th KES International Conference on Innovation in Medicine and Healthcare

CERN Document Server

Tanaka, Satoshi; Howlett, Robert; Jain, Lakhmi; InMed-16; Innovation in Medicine and Healthcare 2016

2016-01-01

This proceedings volume includes 32 papers, which present recent trends and innovations in medicine and healthcare including Innovative Technology in Mental Healthcare; Intelligent Decision Support Technologies and Systems in Healthcare; Biomedical Engineering, Trends, Research and Technologies; Advances in Data & Knowledge Management for Healthcare; Advanced ICT for Medical and Healthcare; Healthcare Support System; and Smart Medical and Healthcare System. Innovation in medicine and healthcare is an interdisciplinary research area, which combines the advanced technologies and problem solving skills with medical and biological science. A central theme of this proceedings is Smart Medical and Healthcare Systems (modern intelligent systems for medicine and healthcare), which can provide efficient and accurate solution to problems faced by healthcare and medical practitioners today by using advanced information communication techniques, computational intelligence, mathematics, robotics and other advanced tec...

A simple method of fabricating mask-free microfluidic devices for biological analysis.

KAUST Repository

Yi, Xin; Kodzius, Rimantas; Gong, Xiuqing; Xiao, Kang; Wen, Weijia

2010-01-01

We report a simple, low-cost, rapid, and mask-free method to fabricate two-dimensional (2D) and three-dimensional (3D) microfluidic chip for biological analysis researches. In this fabrication process, a laser system is used to cut through paper

World-First Innovations in an Open Innovation Context