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1

The severity of coronary artery disease evaluated by central systolic pressure and fractional diastolic pressure  

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Full Text Available Background: Central pulse pressure, pulse pressure index and fractional pulse pressure have been confirmed to be associated with increased risk of cardiovascular disease, but if the severity of cardiovascular disease, specifically for the coronary artery disease, is evaluated by central systolic pressure and fractional diastolic pressure has been not well studied. Aims: This study was designed to examine if central systolic pressure and fractional diastolic pressure could act as a predicting factor for the severity of coronary artery disease. Patients and Methods: A total of 310 patients were included in this study. 154 patients were diagnosed with coronary artery disease, and 156 with non-coronary artery disease, which was confirmed with diagnostic coronary angiography. The average age and sex in the two groups were same. Results: Age, peripheral and central systolic blood pressure, fractional systolic pressure, and fractional diastolic pressure were significantly higher in the patients with coronary artery disease (P<0.05. The central fractional systolic pressure and fractional diastolic pressure were abnormal in the patients with coronary artery disease. Central fractional systolic pressure and fractional diastolic pressure presented a positive correlation between them and coronary Gensini Score (P<0.05, in the patients with coronary artery disease. Conclusions: The severity of coronary artery disease may be predicted by examination of central fractional systolic pressure and fractional diastolic pressure.

Song-Tao An

2010-05-01

2

[Significance of pulmonary artery diastolic pressure after myocardial infarction for physical training (author's transl)].  

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Functional disorders of the left ventricle after myocardial infarction at rest and with exercise can be evaluated with right heart floating catheter by measuring pulmonary artery diastolic pressure. 45% of 200 patients with myocardial infarctions did not tolerate bicycle exercise test with a work load of 50 Watt during 6 minutes. A routine digitalisation of these patients without strict indication did not improve the results. The upper borderline to admit a physical training program is a pulmonary artery diastolic pressure of 20 mm Hg; this should be realised otherwise additional complications have to be expected in long term follow up. The effects of digitalis should be controlled with floating catheter observations in these patients too. There are some indications, that it is possible with the same technique to evaluate hemodynamic responses on psychological strain. Measurements of pulmonary artery diastolic pressure after myocardial infarction open a wide field for individual therapy from drugs to physical training and even to behaviour therapy for stressfull situations. PMID:685379

Koenig, W; Toth, L; Többicke, K; Linden, G; Kohn, E

1978-07-01

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Increased response of diastolic blood pressure to exercise in patients with coronary artery disease: an index of latent ventricular dysfunction?  

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OBJECTIVE--To determine whether an abnormal response of diastolic blood pressure during treadmill exercise stress testing correlated with the number of obstructed vessels and with left ventricular systolic function in patients with coronary artery disease. DESIGN--Diastolic blood pressure was measured invasively during exercise stress testing and coronary angiograms and left ventriculograms were obtained at rest in patients with coronary artery disease. The abnormal (> or = 15 mm Hg) diastoli...

Paraskevaidis, I. A.; Kremastinos, D. T.; Kassimatis, A. S.; Karavolias, G. K.; Kordosis, G. D.; Kyriakides, Z. S.; Toutouzas, P. K.

1993-01-01

4

The effects of acute hypobaric hypoxia on arterial stiffness and endothelial function and its relationship to changes in pulmonary artery pressure and left ventricular diastolic function.  

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This study investigated, for the first time, the effects of simulated high altitude, following acute hypobaric hypoxia (HH), on simultaneous assessment of large artery stiffness and endothelial function and its inter-relationship to left ventricular (LV) diastolic function, pulmonary artery systolic pressure (PASP), and estimated PA vascular resistance (PVR). Ten healthy subjects were studied at baseline pre and following acute HH to 4800?m for a total of 180 minutes. Assessments of LV diastolic function, mitral inflow, estimated LV filling pressure (E/e'), PVR, and PASP were undertaken using transthoracic echocardiography. Simultaneous assessments of arterial stiffness index (SI), systemic vascular resistance (SVR), vascular tone, and endothelial function (reflective index [RI]) were performed using pulse contour analysis of the digital arterial waveform. Acute hypoxia led to a fall in SpO? (98.1±0.7 vs. 71.8±7.1%; p=0.0002), SVR (1589.1±191.2 vs. 1187.8±248.7; p=0.004), and RI (50.8±10.3 vs. 33.0±6.5%; p=0.0008) with an increase in PASP (24.3±2.2 to 35.0±5.3?mmHg; p=0.0001) and estimated PVR (116.40±19.0 vs. 144.6±21.5; pr=-0.77; pr=-0.57; p=0.008) and between the fall in SpO? and change (?) in RI (baseline vs. 150?min, r=-0.52; pr=-0.55; p=0.10) and a strong inverse correlation between ?RI and ?PVR (r=-0.89; p=0.0007). Acute hypobaric hypoxia does not significantly alter large artery stiffness or cause overt LV diastolic function. However, the degree of hypoxia influences both the systemic endothelial and pulmonary vascular responses. This noted association is intriguing and requires further investigation. PMID:22724613

Boos, C J; Hodkinson, P; Mellor, A; Green, N P; Woods, D R

2012-06-01

5

Relation of epicardial fat to central aortic pressure and left ventricular diastolic function in patients with known or suspected coronary artery disease.  

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The present study tested the hypothesis that epicardial fat may be associated with augmented central aortic pressure and impaired left ventricular (LV) function. We studied 134 consecutive patients undergoing left-sided cardiac catheterization for coronary artery disease (CAD) and examined the relation of epicardial fat volume measured by multi-detector computed tomography to ascending aortic pressure and LV ejection fraction determined by cardiac catheterization as well as indices of LV diastolic function assessed by Doppler echocardiography [early diastolic mitral annular velocity (e') and a ratio of early diastolic mitral inflow to annular velocities (E/e')]. Epicardial fat volume indexed to body surface area correlated positively with age (r = 0.24, P < 0.01), body mass index (r = 0.38, P < 0.001), systolic aortic pressure (r = 0.21, P < 0.05), aortic pulse pressure (r = 0.23, P < 0.01), LV ejection fraction (r = 0.22, P < 0.05) and E/e' (r = 0.24, P < 0.05) and did negatively with e' (r = -0.31, P < 0.05). In multivariate linear regression including potential confounders, increased epicardial fat volume index correlated with aortic systolic and pulse pressure and LV diastolic function indices, but not LV ejection fraction. In conclusion, we found that epicardial fat was associated with augmented central aortic pressure and LV diastolic dysfunction in patients with known or suspected CAD. PMID:24943993

Hachiya, Kenta; Fukuta, Hidekatsu; Wakami, Kazuaki; Goto, Toshihiko; Tani, Tomomitsu; Ohte, Nobuyuki

2014-10-01

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Abnormal shortened diastolic time length at increasing heart rates in patients with abnormal exercise-induced increase in pulmonary artery pressure  

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Full Text Available Abstract Background The degree of pulmonary hypertension is not independently related to the severity of left ventricular systolic dysfunction but is frequently associated with diastolic filling abnormalities. The aim of this study was to assess diastolic times at increasing heart rates in normal and in patients with and without abnormal exercise-induced increase in pulmonary artery pressure (PASP. Methods. We enrolled 109 patients (78 males, age 62 ± 13 years referred for exercise stress echocardiography and 16 controls. The PASP was derived from the tricuspid Doppler tracing. A cut-off value of PASP ? 50 mmHg at peak stress was considered as indicative of abnormal increase in PASP. Diastolic times and the diastolic/systolic time ratio were recorded by a precordial cutaneous force sensor based on a linear accelerometer. Results At baseline, PASP was 30 ± 5 mmHg in patients and 25 ± 4 in controls. At peak stress the PASP was normal in 95 patients (Group 1; 14 patients (Group 2 showed an abnormal increase in PASP (from 35 ± 4 to 62 ± 12 mmHg; P Conclusion The first and second heart sound vibrations non-invasively monitored by a force sensor are useful for continuously assessing diastolic time during exercise. Exercise-induced abnormal PASP was associated with reduced diastolic time at heart rates beyond 100 beats per minute.

Bombardini Tonino

2011-11-01

7

Abnormal shortened diastolic time length at increasing heart rates in patients with abnormal exercise-induced increase in pulmonary artery pressure  

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Background The degree of pulmonary hypertension is not independently related to the severity of left ventricular systolic dysfunction but is frequently associated with diastolic filling abnormalities. The aim of this study was to assess diastolic times at increasing heart rates in normal and in patients with and without abnormal exercise-induced increase in pulmonary artery pressure (PASP). Methods. We enrolled 109 patients (78 males, age 62 ± 13 years) referred for exercise stress echocardiography and 16 controls. The PASP was derived from the tricuspid Doppler tracing. A cut-off value of PASP ? 50 mmHg at peak stress was considered as indicative of abnormal increase in PASP. Diastolic times and the diastolic/systolic time ratio were recorded by a precordial cutaneous force sensor based on a linear accelerometer. Results At baseline, PASP was 30 ± 5 mmHg in patients and 25 ± 4 in controls. At peak stress the PASP was normal in 95 patients (Group 1); 14 patients (Group 2) showed an abnormal increase in PASP (from 35 ± 4 to 62 ± 12 mmHg; P < 0.01). At 100 bpm, an abnormal (< 1) diastolic/systolic time ratio was found in 0/16 (0%) controls, in 12/93 (13%) Group 1 and 7/14 (50%) Group 2 patients (p < 0.05 between groups). Conclusion The first and second heart sound vibrations non-invasively monitored by a force sensor are useful for continuously assessing diastolic time during exercise. Exercise-induced abnormal PASP was associated with reduced diastolic time at heart rates beyond 100 beats per minute. PMID:22104611

2011-01-01

8

THE INFLUENCE OF ARTERIAL HYPERTENSION ON THE LEFT VENTRICLAR DIASTOLIC FUNCTION  

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Full Text Available The changes in the heart diastolic function are early functional disturbances in arterial hypertension and are present before the changes in the systolic function. The aim of this research was to study the influence of arterial hypertension on the left ventricular diastolic function. The research included a group of 126 subjects: 93 patients with arterial hypertension and 33 healthy subjects, who were the control group. The patients with arterial hypertension, compared to the control group, had a significantly higher: BMI (p < 0,001, left ventricular mass (p < 0,001, left ventricular mass index (p < 0,001 and the left atrium (p < 0,001. The parameters of the diastolic function in patients with arterial hypertension compared to the control group have shown statistically significant differences: IVRT (p < 0,001 and DT (p < 0,01 are significantly longer and the ratio E/A (p < 0,01 is significantly lower, which gives the image of delayed relaxation. The quotient of linear correlation of IVRT with the systolic and diastolic blood pressure has shown that IVRT statistically significantly correlates both with the systolic blood pressure (p < 0,005 and the diastolic blood pressure (p < 0,05. DT in correlations did not show the dependence on systolic and diastolic blood pressure. The quotient of the linear correlations of the E/A ratio with the systolic and diastolic blood pressure has shown that the E/A ratio, statistically significantly, negatively correlates with systolic blood pressure (p < 0,005 and diastolic blood pressure (p < 0,05. The changes in the left ventricular diastolic function in arterial hypertension are reversible and the condition for that is a good regulation of the blood pressure with hygienic and dietetic measures and medicaments.

Milan Pavlovic

2006-04-01

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Diastolic aortic pressure rise during percutaneous transluminal coronary angioplasty: an index of left ventricular systolic dysfunction.  

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OBJECTIVES--To investigate the relation between diastolic aortic pressure response and left ventricular systolic dysfunction during percutaneous transluminal coronary angioplasty. BACKGROUND--The abnormal diastolic blood pressure rise during exercise in patients with coronary artery disease probably reflects left ventricular systolic dysfunction rather than the number of stenosed coronary arteries. METHODS--Aortic blood pressures and left ventricular systolic function indices were estimated i...

Paraskevaidis, I. A.; Kyriakides, Z. S.; Kassimatis, A. K.; Apostolou, T. P.; Kalopisis, G. K.; Kremastinos, D. T.

1995-01-01

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Dynamics of diastolic sounds caused by partially occluded coronary arteries.  

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The aim of this project is to improve the detection of coronary occlusions using an approach based on the recording and analysis of isolated diastolic heart sounds associated with turbulent blood flow in occluded coronary arteries. The nonlinear dynamic analysis method based on approximate entropy has been proposed for the analysis of diastolic heart sounds. A commercially available electronic stethoscope was used to record the diastolic heart sounds from patients diagnosed with or without coronary artery disease (CAD) based on their coronary angiography examination. The nonlinear dynamical analysis (approximate entropy) measures of the diastolic heart sounds recorded from 30 patients with coronary occlusions and ten normal subjects were estimated. Results suggest the presence of the high nonlinear (approximate entropy) values of diastolic heart sounds associated with CAD (p < 0.05). This approach led to a sensitivity of 77%, a specificity of 80%, and an overall accuracy of 78%. As a summary, 23 out of 30 abnormal patients and eight out of ten normal patients were correctly detected. PMID:19272945

Akay, Metin; Akay, Yasemin M; Gauthier, Dominique; Paden, Robert G; Pavlicek, William; Fortuin, F David; Sweeney, John P; Lee, Richard W

2009-02-01

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Left ventricular diastolic function in patients with coronary artery disease  

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In 302 patients with confirmed coronary disease we determined the left ventricular diastolic function with the Nuclear Stethoscope by the aid of the Peak Filling Rate (PFR) and the Time to Peak Filling Rate (TPFR). Moreover we investigated the ejection fraction (EF). 201 patients had already suffered a myocardial infarction, of these 99 an anterior wall and 102 an inferior wall infarction. The remaining 101 patients had a CAD without a history of myocardial infarction. The PFR was 2.19 +- 0.65 EDV/sec in the 99 patients after anterior wall infarction and 2.62 +- 0.85 EDV/sec in the 102 patients after inferior wall infarction and 2.79 +- 0.85 EDV/sec in 101 patients with coronary artery disease without a history of myocardial infarction. For the PFR there could be found a statistically significant difference between normal patients and patients after anterior wall infarction (p < 0.0001), normal patients and patients after inferior wall infarction (p < 0.0001) and normal patients and patients with coronary artery disease (p < 0.0001). The TPFR was 180 +- 37.5 msec after anterior - and 158 +- 50.7 msec after inferior wall infarction and 156 +- 45.2 msec in the patients with CAD without previous infarction. The left ventricular diastolic function (PFR and/or TPFR) was abnormal in 88% after anterior- and in 82% after inferior wall infarction and in 69% in coronary patients without previous myocardial infarction. In comparison with this the ejection fraction was reduced in 66% in anterior- and in 61% inferior wall infarction at rest. These results indicate that the diastolic function at rest appears to be more informative for evaluation of a left ventricular dysfunction than the systolic function at rest.

Brugger, P.T.

1986-08-01

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Prognostic Value of Left Ventricular Diastolic Dysfunction in Patients Undergoing Cardiac Catheterization for Coronary Artery Disease  

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We hypothesized that left ventricular (LV) diastolic dysfunction assessed by cardiac catheterization may be associated with increased risk for cardiovascular events. To test the hypothesis, we assessed diastolic function by cardiac catheterization (relaxation time constant (Tau) and end-diastolic pressure (EDP)) as well as Doppler echocardiography (early diastolic mitral annular velocity (e?) and a ratio of early diastolic mitral inflow to annular velocities (E/e?)) in 222 consecutive pat...

Genjiro Kimura; Tomomitsu Tani; Toshihiko Goto; Kazuaki Wakami; Nobuyuki Ohte; Hidekatsu Fukuta

2012-01-01

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Effect of absent end diastolic flow velocity in the fetal umbilical artery on subsequent outcome  

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Sixty babies, delivered over a six and a half year period, who had absent end diastolic frequency (AEDF) in the umbilical artery, were studied. Individually matched control pregnancies for gestational age, birthweight, maternal clinical condition and date of delivery, in whom umbilical artery recordings showed end diastolic frequency, were also studied.?  Matching was achieved in 36 cases. Neonates from case pregnancies showed no increase in necrotising enterocolitis, intraventricular ha...

Adiotomre, P.; Johnstone, F.; Laing, I.

1997-01-01

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The influence of glycemia on the left ventricular diastolic function in patients with arterial hypertension  

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Full Text Available Introduction. Arterial hypertension is a disease which has influence on the left ventricular diastolic function. It has been suggested that impairment of the left ventricular diastolic function in patients with diabetes mellitus is due to arterial hypertension and diffuse peripherial and coronary atherosclerosis which appear early in diabetic patients. Now, however, it is thought, that other mechanisms are responsable for the development of diabetic cardiomyopathy. The aim of the study was to investigate the effect of glycemia on the left ventricular diastolic function in patients with arterial hypertension. Methods. The study included 60 patients with arterial hypertension: 30 (50,00% patients with diabetes mellitus and 30 (50,00% with­out diabetes mellitus. The parameters of diastolic function were measured by the pulsed Doppler echocardiographic technique. Isovolumetric relaxation time, deceleration time, maximum velocity of the early stage of ventricular filling, maximum velocity of the late stage of ventricular filling and the early/late stage of ventricular filling ratio were used to assess the diastolic function. Results. The patients with arterial hypertension and diabetes mellitus compared to the patients with arterial hypertension without diabetes mellitus were significantly obese (p 0.001, had significantly higher glycemia (p<0.0001 and left atrial volume (p<0.05. The patients with arterial hypertension and diabetes mellilus compared to the patients with arterial hypertension without diabetes mellitus had significanllly: longer deceleration time (p< 0.05, lower velocity of early stage of ventricular filling (p<0.05 and lower early/late stage oj ventricular filling ratio (p<0.01. Conclusion. Diastolic function parameters of patients with diabetes mellitus are significantly changed: deceleration time is longer, early stage of ventricular filling and early/late ventricular filling ratio are lower.

Milutinovi? Suzana

2008-01-01

15

Diastolic blood pressure influences cerebrovascular reactivity measured by means of 123I-iodoamphetamine brain single photon emission computed tomography in medically treated patients with occlusive carotid or middle cerebral artery disease  

International Nuclear Information System (INIS)

elated with those in average diastolic BP in the ipsilateral hemisphere (y=0.71x+1.43, r2=0.11, p2=0.16, p123I-IMP SPECT was influenced by the diastolic BP at the SPECT studies. Monitoring diastolic BP is important to evaluate interval change in CVR. (author)

16

Change of blood pressure and systolic/diastolic hypertension in Nagasaki A-bomb survivors  

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Changes in blood pressure and systolic/diastolic hypertension in Nagasaki A-bomb survivors were surveyed from 1973 to 1982. Systolic hypertension tended to decrease, while diastolic hypertension tended to increase in younger male survivors. The incidence of hypertension tended to decrease or be constant. According to the WHO classification of hypertension, the type of H, in which both diastolic and systolic blood pressures were high, and the type of SH, in which only systolic blood pressure was high, tended to decrease, while the type of DH, in which only diastolic blood pressure was high, tended to increase. (Namekawa, K.)

17

Left ventricular end-diastolic pressure affects measurement of fractional flow reserve  

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Background Fractional flow reserve (FFR), the hyperemic ratio of distal (Pd) to proximal (Pa) coronary pressure, is used to identify the need for coronary revascularization. Changes in left ventricular end-diastolic pressure (LVEDP) might affect measurements of FFR. Methods and Materials LVEDP was recorded simultaneously with Pd and Pa during conventional FFR measurement as well as during additional infusion of nitroprusside. The relationship between LVEDP, Pa, and FFR was assessed using linear mixed models. Results Prospectively collected data for 528 cardiac cycles from 20 coronary arteries in 17 patients were analyzed. Baseline median Pa, Pd, FFR, and LVEDP were 73 mmHg, 49 mmHg, 0.69, and 18 mmHg, respectively. FFR < 0.80 was present in 14 arteries (70%). With nitroprusside median Pa, Pd, FFR, and LVEDP were 61 mmHg, 42 mmHg, 0.68, and 12 mmHg, respectively. In a multivariable model for the entire population LVEDP was positively associated with FFR such that FFR increased by 0.008 for every 1-mmHg increase in LVEDP (beta = 0.008; P < 0.001), an association that was greater in obstructed arteries with FFR < 0.80 (beta = 0.01; P < 0.001). Pa did not directly affect FFR in the multivariable model, but an interaction between LVEDP and Pa determined that LVEDP’s effect on FFR is greater at lower Pa. Conclusions LVEDP was positively associated with FFR. The association was greater in obstructive disease (FFR < 0.80) and at lower Pa. These findings have implications for the use of FFR to guide revascularization in patients with heart failure. Summary for Annotated Table of Contents The impact of left ventricular diastolic pressure on measurement of fractional flow reserve (FFR) is not well described. We present a hemodynamic study of the issue, concluding that increasing left ventricular diastolic pressure can increase measurements of FFR, particularly in patients with FFR < 0.80 and lower blood pressure. PMID:23886870

Leonardi, Robert A.; Townsend, Jacob C.; Patel, Chetan A.; Wolf, Bethany J.; Todoran, Thomas M.; Fernandes, Valerian L.; Nielsen, Christopher D.; Steinberg, Daniel H.; Powers, Eric R.

2013-01-01

18

Analysis of Left Ventricular Diastolic Function in Coronary Artery Disease with Gated Blood Pool Scan  

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Resting gated blood pool scan was used to derive left ventricular functional changes in normals (N=13, mean age=43) and in patients with coronary artery disease (N=50, mean age=53). Peak filling rates, average filling rates, and ejection fractions were significantly depressed m coronary artery disease. (p<0.0005, each other). And in coronary artery disease with normal ejection fraction (N = 21), peak filling rates and average filling rates were depressed also, and peak filling rates of coronary artery disease with normal ejection fraction were abnormal in 61.2% and average filling rates were abnormal in 71.4/. It appears that (1) resting peak filling rates and average filling rates were sensitive and easily obtainable parameters of the diastolic dysfunction associated with coronary artery disease, (2) a significant proportion of coronary artery disease patients without any evidence of abnormal systolic function have depressed resting peak filling rates and average filling rates of the left ventricle.

Choi, Chang Woon; Lim, Sang Moo; Chung, June Key; Lee, Myung Chul; Park, Young Bae; Seo, Joung Don; Lee, Young Woo; Koh, Chang Soon [Seoul National University College of Medicine, Seoul (Korea, Republic of)

1986-09-15

19

Improved left ventricular diastolic filling in patients with coronary artery disease after percutaneous transluminal coronary angioplasty.  

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Left ventricular (LV) diastolic filling is abnormal at rest in many patients with coronary artery disease (CAD), even in the presence of normal resting LV systolic function. To determine the effects of improved myocardial perfusion on impaired. LV diastolic filling, we studied 25 patients with one-vessel CAD by high-temporal-resolution radionuclide angiography before and after percutaneous transluminal coronary angioplasty (PTCA). No patient had ECG evidence of previous myocardial infarction. Despite normal regional and global LV systolic function at rest in all patents, LV diastolic filling was abnormal (peak LV filling rate [PFR] less than 2.5 end-diastolic volumes (EDV)/sec or time to PFR greater than 180 msec) in 17 of 25 patients. Twenty-three patients had abnormal LV systolic function during exercise. After successful PTCA, LV ejection fraction and heart rate at rest were unchanged, but LV ejection fraction during exercise increased, from 52 +/- 8% (+/- SD) to 63 +/- 5% (p less than 0.001). LV diastolic filling at rest improved: PFR increased from 2.3 +/- 0.6 to 2.8 +/- 0.5 EDV/sec (p less than 0.001) and time to PFR decreased from 181 +/- 22 to 160 +/- 18 msec (p less than 0.001). Thus, a reduction in exercise-induced LV systolic dysfunction after PTCA, reflecting a reduction in reversible ischemia, was associated with improved LV diastolic filling at rest. These data suggest that in many CAD patients with normal resting LV systolic function and without previous infarction, abnormalities of resting LV diastolic filling are not fixed, but appear to be reversible manifestations of impaired coronary flow. PMID:6216024

Bonow, R O; Kent, K M; Rosing, D R; Lipson, L C; Bacharach, S L; Green, M V; Epstein, S E

1982-12-01

20

Phase shifts of synchronized oscillators and the systolic/diastolic blood pressure relation  

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We study the phase-synchronization properties of systolic and diastolic arterial pressure in healthy subjects. We find that delays in the oscillatory components of the time series depend on the frequency bands that are considered, in particular we find a change of sign in the phase shift going from the Very Low Frequency band to the High Frequency band. This behavior should reflect a collective behavior of a system of nonlinear interacting elementary oscillators. We prove that some models describing such systems, e.g. the Winfree and the Kuramoto models offer a clue to this phenomenon. For these theoretical models there is a linear relationship between phase shifts and the difference of natural frequencies of oscillators and a change of sign in the phase shift naturally emerges.

Angelini, L; Maestri, R; Marinazzo, D; Nardulli, Giuseppe; Nitti, L; Pellicoro, M; Pinna, G D; Stramaglia, S

2004-01-01

 
 
 
 
21

EFFECT OF GENDER DIFFERENCE AND CIRCADIAN RHYTHM ON DIASTOLIC BLOOD PRESSURE FOR VOLLEYBALL PLAYERS  

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The purpose of the study was to find out the effect of gender difference and circadian rhythm on diastolic blood pressure for volleyball players. METHODS: To achieve the purpose, a total of thirty volleyball players [men (n = 15) and women (n = 15)] age between 19 years and 22 years from Einstein College of Engineering, Tamil Nadu, India were selected as subjects. The two independent variables of gender and circadian variations and dependent variable of diastolic blood pressure were selected ...

Rajagopal, I.

2011-01-01

22

Systolic and diastolic blood pressures as predictors of coronary heart disease mortality in the Whitehall study.  

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Systolic and diastolic blood pressures were compared as predictors of death due to coronary heart disease using data on the 10 year mortality outcome from the 18 403 male civil servants, aged 40-64, in the Whitehall study. There were 727 deaths due to coronary heart disease. At entry to the study the systolic pressure in these men was significantly higher than the diastolic pressure, and a standardised index of relative risk for death from coronary heart disease was greater for systolic blood...

Lichtenstein, M. J.; Shipley, M. J.; Rose, G.

1985-01-01

23

Association of Anemia With Diastolic Dysfunction Among Patients With Coronary Artery Disease in the Heart and Soul Study  

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We performed a cross-sectional study to evaluate the association of anemia with diastolic dysfunction and left ventricular hypertrophy (LVH) in outpatients who had coronary artery disease. Logistic regression was used to examine the association of blood hemoglobin (Hb) concentrations with diastolic dysfunction and LVH in 822 participants in the Heart and Soul Study who had normal sinus rhythm and preserved systolic function (left ventricular ejection fraction ?50%). Using transthoracic echo...

Nair, Deepu; Shlipak, Michael G.; Angeja, Brad; Liu, Haiying H.; Schiller, Nelson B.; Whooley, Mary A.

2005-01-01

24

Comparison of the effect of pressure loading on left ventricular size, systolic and diastolic function in canines with left ventricular dysfunction with preserved and reduced ejection fraction  

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Abstract Background Decompensated heart failure may present with severe hypertension in patients with preserved (PreEF) or reduced left ventricular (LV) ejection fraction (RedEF) and is clinically indistinguishable. Previously, we demonstrated that arterial pressure elevation increases LV filling pressures in a canine model of chronic LV dysfunction with PreEF or RedEF. It is not clear whether any differences in hemodynamics, LV volume or performance, or diastolic function ca...

Lavine Steven J; Conetta Donald A

2008-01-01

25

Evaluación de la función diastólica durante y post-ejercicio isométrico en pacientes con hipertensión arterial / Evaluation of diastolic function during and post-exercise in patients with arterial hypertension  

Scientific Electronic Library Online (English)

Full Text Available SciELO Argentina | Language: Spanish Abstract in spanish Es conocido que los pacientes con hipertrofia ventricular por hipertensión arterial presentan alteraciones diastólicas, particularmente durante el ejercicio. Sin embargo, es controvertido si luego del esfuerzo esta disfunción se normaliza. El objetivo fue evaluar la función diastólica durante y desp [...] ués de la realización de ejercicio, en pacientes con hipertensión arterial. Se estudiaron 6 pacientes controles (grupo 1, G1) y 7 con diagnóstico de hipertensión arterial (Grupo 2, G2). Los pacientes fueron sometidos a un cateterismo cardíaco y realizaron ejercicio isométrico durante el estudio, hasta que la frecuencia cardíaca se incrementó un 43±7% (p Abstract in english It is known that patients with arterial hypertension and ventricular hypertrophy have diastolic alterations, in particular during exercise. However, it is controversial if diastolic dysfunction continues once exercise had concluded. The objective was to assess the effects of isometric exercise on th [...] e diastolic function in patients with arterial hypertension. Five control patients (group 1, G1) and 7 patients with arterial hyper-tension (group 2, G2) were studied. All patients underwent cardiac catheterization and performed isometric exercise until heart rate increased 43±7%. Left ventricular systolic pressure (LVSP) and end diastolic pressure (LVEDP) were measured. We calculated, +dP/dt max, the time constant of isovolumic pressure decay (tau) and t1/2 were all measured. Results: The LVSP increased in G1 and G2 during exercise from 140±3 to 195±14 mm Hg (p

Andrés, Pascua; Martín, Donato; Carlos, Borrego; José, Gabay; Daniel, Berrocal; Ricardo J., Gelpi; Liliana, Grinfeld.

2006-10-01

26

Estimating mean arterial pressure during invasive monitoring using manometer  

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Full Text Available "nBackground: Direct monitoring of arterial pressure using a transducer system is not affordable in most operating rooms and ICU wards in Iran. It is, however, possible to use an aneroid manometer instead, but it is not standardized yet, nor studied enough; and its measurements may not be interpretable. "nMethods: To study the correlation of the arterial pressure readings between a manometer and a transducer system, systolic and diastolic arterial pressure was measured 105 times using both systems via arterial cannulation in seven patients during surgery. Mean arterial pressure was directly recorded in the transducer system, while it was calculated in the manometer system. In the manometer system, the extension tube was filled with saline halfway from the patient and the other empty end was connected to a manometer. The transducer and the air-fluid interface in the extension tube were positioned at same level. Correlation of the arterial pressures between the systems was tested using linear regression and Pearson correlation. "nResults: Mean arterial pressure differed by 2 (1-3 mmHg [mean (CI 95%] between the systems, however, pulse pressure was lower in the manometer system by 37 (33-41 mmHg. The mean arterial pressure in the transducer system (MAPT correlated well and linearly with the systolic arterial pressure in the manometer system (SAPM by R=0.966. Therefore, MAPT can be regarded as a function of SAPM through the following formula: MAPT = (1.03 ´ SAPM - 7.34. "nConclusion: The mean arterial pressure in the transducer system can be reliably estimated by monitoring the systolic arterial pressure in the manometer system.

Gholam Alemohammad M

2009-02-01

27

EFFECT OF GENDER DIFFERENCE AND CIRCADIAN RHYTHM ON DIASTOLIC BLOOD PRESSURE FOR VOLLEYBALL PLAYERS  

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Full Text Available The purpose of the study was to find out the effect of gender difference and circadian rhythm on diastolic blood pressure for volleyball players. METHODS: To achieve the purpose, a total of thirty volleyball players [men (n = 15 and women (n = 15] age between 19 years and 22 years from Einstein College of Engineering, Tamil Nadu, India were selected as subjects. The two independent variables of gender and circadian variations and dependent variable of diastolic blood pressure were selected for this study. The experimental design used was static group factorial design. The data were collected at 02:00, 06:00, 10:00, 14:00, 18:00 and 22:00 hours on diastolic blood pressure by using Erkameter during the academic year of 2009 – 2010. Collected data were subjected to statistical analysis by using two-way factorial (2 x 6 Analysis of Variance (ANOVA and Cosinor analysis. RESULTS: There was insignificant difference between genders, significant difference at different times of the day and insignificant circadian rhythmicity exists on diastolic blood pressure for women and significant for men. CONCLUSION: It is recommended to the physical educators to adopt the findings of this study while planning to improve sports skills for the players and athletes.

I. Rajagopal

2011-04-01

28

Evaluation of the Effect of Elective Percutaneous Coronary Intervention as a Treatment Method on the Left Ventricular Diastolic Dysfunction in Patients with Coronary Artery Disease  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Background: Although percutaneous coronary intervention (PCI) is an excellent therapy for coronary artery disease, there is a paucity of information on the efficacy of PCI in improving diastolic function, especially in Iran. Because of the high prevalence of left diastolic dysfunction in coronary artery disease patients and its probable progression to heart failure, an evaluation of the role of PCI in improving diastolic function is required.Methods: Thirty patients scheduled for elective PCI...

Atieh Rezaeefar; Latif Gachkar; Manouchehr Hekmat; Mohammad Khani; Mohammadreza Motamedi; Seyed Reza Hashemi

2010-01-01

29

Usefulness of diastolic phase indexes by gated cardiac blood pool imaging in patients with coronary artery disease  

International Nuclear Information System (INIS)

In patients with coronary artery disease (CAD), various left ventricular diastolic phase indexes were obtained from multi-gated blood pool imaging with sup(99m)Tc. As early diastolic phase indexes, during the first third of diastole, filling fraction (1/3 FF), mean filling rate (1/3 FR-mean) and maximal filling rate (1/3 FR-max) were calculated. In addition, maximal filling rate during whole diastole (FR-max) was calculated. These diastolic phase indexes correlated with left ventricular ejection fraction (LVEF) (r >= 0.73, p > 0.001). A good reproducibility was obtained in each of diastolic phase index (r >= 0.96). Subjects were divided into 3 groups: Normal (n = 14), Group I (n = 26); CAD with normal LVEF (>= 55%) and normal wall motion and Group II (n = 29); CAD with reduced LVEF and/or abnormal wall motion. With these diastolic phase indexes, 3 groups could be differentiated (p 1/3 FF > 1/3 FR-max > FR-max in order of sensitivity) than systolic functions such as LVEF, wall motion abnormality and mean first third ejection rate (1/3 ER-mean). Abnormality in 1/3 FR-mean (-1) was found in 91% of patients with CAD (81% of Group I, 100% of Group II). The comparison of 1/3 FR-mean with 1/3 ER-mean revealed that early diastolic phase index was sensitive inrly diastolic phase index was sensitive indicator of the left ventricular dysfunction due to myocardial ischemia. (author)

30

Arterial pressure measurement: Is the envelope curve of the oscillometric method influenced by arterial stiffness?  

Science.gov (United States)

Measurement of peripheral arterial pressure using the oscillometric method is commonly used by professionals as well as by patients in their homes. This non invasive automatic method is fast, efficient and the required equipment is affordable with a low cost. The measurement method consists of obtaining parameters from a calibrated decreasing curve that is modulated by heart beats witch appear when arterial pressure reaches the cuff pressure. Diastolic, mean and systolic pressures are obtained calculating particular instants from the heart beats envelope curve. In this article we analyze the envelope of this amplified curve to find out if its morphology is related to arterial stiffness in patients. We found, in 33 volunteers, that the envelope waveform width correlates to systolic pressure (r=0.4, parterial stiffness and can be used to enhance pressure measurements.

Gelido, G.; Angiletta, S.; Pujalte, A.; Quiroga, P.; Cornes, P.; Craiem, D.

2007-11-01

31

Brachial artery waveforms for automatic blood pressure measurement.  

Science.gov (United States)

Theoretically the auscultatory method using Korotkoff sounds is more related to the maximum artery closure status, while the oscillometric method is more related to the overall artery closure status under the cuff. Therefore, the latter is less accurate than the former. This work introduces a new method, which is more accurate than the oscillometric method and suitable for automatic devices. To monitor the maximum artery closure status, a piezoelectric film sensor is attached to the skin just above the brachial artery and under the central section of the cuff where maximum cuff pressure is transferred to the arm. Using the waveform features obtained by this sensor, measurement errors of 0.7±2.5 and 1.27±4.53 mmHg were obtained for the systolic and diastolic pressure, respectively. These reflect small deviations from auscultatory clinical data. PMID:23149078

Al-Jumaily, A M; Lan, H; Stergiopulos, N

2013-02-01

32

[Prognostic criteria of systolic-diastolic correlation of medial cerebral artery of fetus in pregnant women with cytomegalovirus infection].  

Science.gov (United States)

Total of 137 women were studied with pregnancy terms between 20 and 41 weeks; out of them 97 with latent form and reactivation of cytomegalovirus infection, and 40 with non-complicated gestational process. Complex Doppler metrics study of the blood flow in the medial cerebral artery of the fetus using cluster analysis has been carried out. High percentage of complication in the II class of pregnant women has been revealed, where systolic-diastolic correlation index in medial cerebral artery of fetus was in the range of 7.1, compared to I class, where systolic-diastolic correlation index was in the interval of 3.1-7.1. Hypoxic affection of central nervous system in newborn of II class made 59.0+/-6.7% (pcytomegalovirus infection in the III trimester of gestation for revealing perinatal pathology high risk groups. PMID:17057307

Shamsadinskaia, N M; Shamsadinskaia, N M

2006-09-01

33

Rats with high left ventricular end-diastolic pressure can be identified by Doppler echocardiography one week after myocardial infarction  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in english The severity of left ventricular (LV) dysfunction in rats with myocardial infarction (MI) varies widely. Because homogeneity in baseline parameters is essential for experimental investigations, a study was conducted to establish whether Doppler echocardiography (DE) could accurately identify animals [...] with high LV end-diastolic pressure as a marker of LV dysfunction soon after MI. Direct measurements of LV end-diastolic pressure were made and DE was performed simultaneously 1 week after surgically induced MI (N = 16) or sham-operation (N = 17) in female Wistar rats (200 to 250 g). The ratio of peak early (E) to late (A) diastolic LV filling velocities and the ratio of E velocity to peak early (Em) diastolic myocardial velocity were the best predictors of high LV end-diastolic pressure (>12 mmHg) soon after MI. Cut-off values of 1.77 for the E/A ratio (P = 0.001) identified rats with elevated LV end-diastolic pressure with 90% sensitivity and 80% specificity. Cut-off values of 20.4 for the E/Em ratio (P = 0.0001) identified rats with elevated LV end-diastolic pressure with 81.8% sensitivity and 80% specificity. Moreover, E/A and E/Em ratios were the only echocardiographic parameters independently associated with LV end-diastolic pressure in multiple linear regression analysis. Therefore, DE identifies rats with high LV end-diastolic pressure soon after MI. These findings have implications for using serial DE in animal selection and in the assessment of their response to experimental therapies.

R.M., Saraiva; R.M., Kanashiro-Takeuchi; E.L., Antonio; O., Campos; P.J.F., Tucci; V.A., Moisés.

1557-15-01

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Rats with high left ventricular end-diastolic pressure can be identified by Doppler echocardiography one week after myocardial infarction  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in english The severity of left ventricular (LV) dysfunction in rats with myocardial infarction (MI) varies widely. Because homogeneity in baseline parameters is essential for experimental investigations, a study was conducted to establish whether Doppler echocardiography (DE) could accurately identify animals [...] with high LV end-diastolic pressure as a marker of LV dysfunction soon after MI. Direct measurements of LV end-diastolic pressure were made and DE was performed simultaneously 1 week after surgically induced MI (N = 16) or sham-operation (N = 17) in female Wistar rats (200 to 250 g). The ratio of peak early (E) to late (A) diastolic LV filling velocities and the ratio of E velocity to peak early (Em) diastolic myocardial velocity were the best predictors of high LV end-diastolic pressure (>12 mmHg) soon after MI. Cut-off values of 1.77 for the E/A ratio (P = 0.001) identified rats with elevated LV end-diastolic pressure with 90% sensitivity and 80% specificity. Cut-off values of 20.4 for the E/Em ratio (P = 0.0001) identified rats with elevated LV end-diastolic pressure with 81.8% sensitivity and 80% specificity. Moreover, E/A and E/Em ratios were the only echocardiographic parameters independently associated with LV end-diastolic pressure in multiple linear regression analysis. Therefore, DE identifies rats with high LV end-diastolic pressure soon after MI. These findings have implications for using serial DE in animal selection and in the assessment of their response to experimental therapies.

R.M., Saraiva; R.M., Kanashiro-Takeuchi; E.L., Antonio; O., Campos; P.J.F., Tucci; V.A., Moisés.

35

Double product response and diastolic blood pressure in treadmill, stationary bicycle and muscular circuit exercises  

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Full Text Available Among the various causes for cardiovascular problems affecting the world population nowadays, the most relevant risk factors is sedentary lifestyle. Many studies have been carried out to analyse and elucidate main adaptations on the cardiovascular system stimulated by different sorts of exercises.In this way, this study had aimed at comparing the acute response of double product (DP and diastolic blood pressure (DBP after treadmill (TRM, stationary bicycle (BIC or muscle circuit training (MCT exercises. Nine individuals (6 women and 3 men exercised at 60% of heart rate reserve (HRR on the TRM and BIC and at 60% of one repetition maximum (1RM in MCT. The results showed that pre- and post-effort DP were significantly difference in all three exercises. However, DP did not differ among exercise types. The hypotensive DBP pos-effort response was greater in MCT. According to the results, it was concluded that there is no difference on the heart work demand rate estimated by DP among the three exercises and MCT at 60% 1RM provokes a greater hypotensive DBP post-effort response. . Resumo Entre as diversas causas de problemas cardiovasculares que afetam a população mundial, na atualidade, o sedentarismo é apontado como um dos fatores de risco mais relevantes. Vários estudos têm se preocupado em analisar e esclarecer as principais adaptações provocadas pelos diferentes tipos de exercícios sobre o sistema cardiovascular. Seguindo esta linha o presente trabalho teve como objetivo analisar e comparar a resposta aguda do duplo produto (DP e a pressão arterial diastólica (PAD em exercício de esteira, bicicleta estacionária e circuito na musculação. Foram avaliados nove indivíduos sendo seis mulheres e três homens, na esteira, a 60% da freqüência cardíaca de reserva (FCR, na bicicleta estacionária, a 60% FCR e circuito de musculação a 60% de 1 repetição máxima (1RM. Os resultados encontrados apresentaram diferença significativa do DP pré e pós esforço nos três exercícios. Quando comparado, o DP obtido pós esforço, nos três exercícios, não houve diferença significativa. A resposta hipotensiva da PAD pós-esforço foi mais acentuada após exercício de circuito em musculação, quando comparada com as outras modalidades exercício analisadas. De acordo com os procedimentos metodológicos adotados e os resultados obtidos, concluiu-se que não há diferença na taxa de exigência de trabalho do miocárdio entre os três exercicios analisados e que o circuito de musculação, a 60% 1RM, provoca uma maior resposta hipotensiva da PAD pós-esforço.

Leandro Teixeira Paranhos Lopes

2006-08-01

36

Double product response and diastolic blood pressure in treadmill, stationary bicycle and muscular circuit exercises  

Directory of Open Access Journals (Sweden)

Full Text Available Among the various causes for cardiovascular problems affecting the world population nowadays, the most relevant risk factors is sedentary lifestyle. Many studies have been carried out to analyse and elucidate main adaptations on the cardiovascular system stimulated by different sorts of exercises.In this way, this study had aimed at comparing the acute response of double product (DP and diastolic blood pressure (DBP after treadmill (TRM, stationary bicycle (BIC or muscle circuit training (MCT exercises. Nine individuals (6 women and 3 men exercised at 60% of heart rate reserve (HRR on the TRM and BIC and at 60% of one repetition maximum (1RM in MCT. The results showed that pre- and post-effort DP were significantly difference in all three exercises. However, DP did not differ among exercise types. The hypotensive DBP pos-effort response was greater in MCT. According to the results, it was concluded that there is no difference on the heart work demand rate estimated by DP among the three exercises and MCT at 60% 1RM provokes a greater hypotensive DBP post-effort response. RESUMO Entre as diversas causas de problemas cardiovasculares que afetam a população mundial, na atualidade, o sedentarismo é apontado como um dos fatores de risco mais relevantes. Vários estudos têm se preocupado em analisar e esclarecer as principais adaptações provocadas pelos diferentes tipos de exercícios sobre o sistema cardiovascular. Seguindo esta linha o presente trabalho teve como objetivo analisar e comparar a resposta aguda do duplo produto (DP e a pressão arterial diastólica (PAD em exercício de esteira, bicicleta estacionária e circuito na musculação. Foram avaliados nove indivíduos sendo seis mulheres e três homens, na esteira, a 60% da freqüência cardíaca de reserva (FCR, na bicicleta estacionária, a 60% FCR e circuito de musculação a 60% de 1 repetição máxima (1RM. Os resultados encontrados apresentaram diferença significativa do DP pré e pós esforço nos três exercícios. Quando comparado, o DP obtido pós esforço, nos três exercícios, não houve diferença significativa. A resposta hipotensiva da PAD pós-esforço foi mais acentuada após exercício de circuito em musculação, quando comparada com as outras modalidades exercício analisadas. De acordo com os procedimentos metodológicos adotados e os resultados obtidos, concluiu-se que não há diferença na taxa de exigência de trabalho do miocárdio entre os três exercicios analisados e que o circuito de musculação, a 60% 1RM, provoca uma maior resposta hipotensiva da PAD pós-esforço.

Elmiro Santos Resende

2006-06-01

37

Arterial pressure measurement: Is the envelope curve of the oscillometric method influenced by arterial stiffness?  

International Nuclear Information System (INIS)

Measurement of peripheral arterial pressure using the oscillometric method is commonly used by professionals as well as by patients in their homes. This non invasive automatic method is fast, efficient and the required equipment is affordable with a low cost. The measurement method consists of obtaining parameters from a calibrated decreasing curve that is modulated by heart beats witch appear when arterial pressure reaches the cuff pressure. Diastolic, mean and systolic pressures are obtained calculating particular instants from the heart beats envelope curve. In this article we analyze the envelope of this amplified curve to find out if its morphology is related to arterial stiffness in patients. We found, in 33 volunteers, that the envelope waveform width correlates to systolic pressure (r=0.4, p<0.05), to pulse pressure (r=0.6, p<0.05) and to pulse pressure normalized to systolic pressure (r=0.6, p<0.05). We believe that the morphology of the heart beats envelope curve obtained with the oscillometric method for peripheral pressure measurement depends on arterial stiffness and can be used to enhance pressure measurements

38

Arterial pressure measurement: Is the envelope curve of the oscillometric method influenced by arterial stiffness?  

Energy Technology Data Exchange (ETDEWEB)

Measurement of peripheral arterial pressure using the oscillometric method is commonly used by professionals as well as by patients in their homes. This non invasive automatic method is fast, efficient and the required equipment is affordable with a low cost. The measurement method consists of obtaining parameters from a calibrated decreasing curve that is modulated by heart beats witch appear when arterial pressure reaches the cuff pressure. Diastolic, mean and systolic pressures are obtained calculating particular instants from the heart beats envelope curve. In this article we analyze the envelope of this amplified curve to find out if its morphology is related to arterial stiffness in patients. We found, in 33 volunteers, that the envelope waveform width correlates to systolic pressure (r=0.4, p<0.05), to pulse pressure (r=0.6, p<0.05) and to pulse pressure normalized to systolic pressure (r=0.6, p<0.05). We believe that the morphology of the heart beats envelope curve obtained with the oscillometric method for peripheral pressure measurement depends on arterial stiffness and can be used to enhance pressure measurements.

Gelido, G [Electronic department, Universidad Tecnologica Nacional FRBA, Bs. As. (Argentina); Angiletta, S [Electronic department, Universidad Tecnologica Nacional FRBA, Bs. As. (Argentina); Pujalte, A [Electronic department, Universidad Tecnologica Nacional FRBA, Bs. As. (Argentina); Quiroga, P [Electronic department, Universidad Favaloro FICEN, Bs. As. (Argentina); Cornes, P [Electronic department, Universidad Favaloro FICEN, Bs. As. (Argentina); Craiem, D [Electronic department, Universidad Favaloro FICEN, Bs. As. (Argentina)

2007-11-15

39

Usefulness of the ratio of transmitral E wave velocity to isovolumic relaxation flow propagation velocity for predicting left ventricular end-diastolic pressure.  

Science.gov (United States)

Transmitral E wave velocity was reported to be positively related to left ventricular (LV) filling pressure and negatively related to LV relaxation constant, and isovolumic relaxation flow propagation velocity (IRFPV) was proven recently to be negatively related to LV relaxation constant and independent of preload alterations. Therefore, the combination index, E/IRFPV, may eliminate the influence of LV relaxation and bring the LV filling pressure into focus. However, it is unknown whether E/IRFPV is a useful index in prediction of LV filling pressure. The aim of this study is to evaluate the correlation between E/IRFPV and LV end-diastolic pressure (LVEDP). Forty-three patients with suspected coronary artery disease who underwent a Doppler echocardiographic study and cardiac catheterization were included. LVEDP was determined by a micromanometer-tipped catheter. In a univariate analysis, LVEDP had a positive correlation with left atrial dimension, LV end-diastolic dimension, LV end-systolic dimension, the ratio of E to E wave propagation velocity (EPV) (r = 0.408, p = 0.007), the ratio of E to early diastolic mitral annular velocity (Ea) (r = 0.439, p = 0.003) and E/IRFPV (r = 0.686, p EPV, Ea and IRFPV. After stepwise multiple linear regression analysis, only the E/IRFPV was the independent predictor of LVEDP (beta = 0.667, p < 0.001). In conclusion, E/IRFPV is a useful parameter in prediction of LVEDP. PMID:18538465

Su, Ho-Ming; Lin, Tsung-Hsien; Lee, Chee-Siong; Lin, Chien-Tsai; Tang, Min-Hua; Chin, Tan-Tze; Lai, Wen-Ter; Sheu, Sheng-Hsiung; Voon, Wen-Chol

2008-11-01

40

Blood pressure evaluation using sphygmomanometry assisted by arterial pulse waveform detection by fiber Bragg grating pulse device  

Science.gov (United States)

We report a blood pressure evaluation methodology by recording the radial arterial pulse waveform in real time using a fiber Bragg grating pulse device (FBGPD). Here, the pressure responses of the arterial pulse in the form of beat-to-beat pulse amplitude and arterial diametrical variations are monitored. Particularly, the unique signatures of pulse pressure variations have been recorded in the arterial pulse waveform, which indicate the systolic and diastolic blood pressure while the patient is subjected to the sphygmomanometric blood pressure examination. The proposed method of blood pressure evaluation using FBGPD has been validated with the auscultatory method of detecting the acoustic pulses (Korotkoff sounds) by an electronic stethoscope.

Sharath, Umesh; Sukreet, Raju; Apoorva, Girish; Asokan, Sundarrajan

2013-06-01

 
 
 
 
41

Detection of diastolic abnormality by dyssynchrony imaging. Correlation with coronary artery disease in patients presenting with visibly normal wall motion  

International Nuclear Information System (INIS)

Post-systolic shortening (PSS) is a sensitive indicator of myocardial ischemia. We have developed a tissue Doppler imaging technique that portrays PSS, and whether PSS correlates with coronary artery disease (CAD) was investigated in 186 patients presenting with chest pain and normal echocardiograms. Delays of the displacement peaks from end-systole were calculated in the apical views and displayed from green (0 ms) to red (?100 ms): detection of diastolic abnormality by dyssynchrony imaging (DADI). CAD was judged positive by DADI when the left ventricular segments were color-coded red. Patients subsequently underwent thallium-201 myocardial perfusion single-photon emission computed tomography (n=150), coronary angiography (CAG, n=74), or both (n=37). CAD(-) was defined as negative scintigraphy test and/or no significant coronary artery stenosis by CAG. In 43 patients (23%), CAD(+) was confirmed by CAG as >75% diameter stenosis. DADI predicted CAD with sensitivity of 60%, specificity of 75%, predictive accuracy of 72%, positive predictive value of 42%, and negative predictive value of 86%. Among 74 patients who underwent CAG, sensitivity was best for the left anterior descending artery. DADI detected the regional diastolic abnormality, which correlated with the presence of CAD in patients presenting with visibly normal wall motion. (author)

42

Reconstruction of brachial pressure from finger arterial pressure during orthostasis  

DEFF Research Database (Denmark)

In patients with recurrent syncope, monitoring of intra-arterial pressure during orthostatic stress testing is recommended because of the potentially sudden and rapid development of hypotension. Replacing brachial arterial pressure (BAP) by the non-invasively obtained finger arterial pressure (FinAP) has advantages because catheterization in itself may provoke a syncope.

Bogert, Lysander W J; Harms, Mark P M

2004-01-01

43

Higher diastolic blood pressure at admission and antiedema therapy is associated with acute kidney injury in acute ischemic stroke patients.  

Science.gov (United States)

Antiedema therapy with mannitol and furosemide is widely used for prevention and management of cerebral edema, elevated intracranial pressure, and cerebral hernia. There are some reports about mannitol and furosemide as risk factors of acute kidney injury (AKI). We investigated the risk factors for AKI including antiedema therapy in acute ischemic stroke patients. The subjects were 129 patients with acute ischemic stroke including 56 females and 73 males with a mean age 68.16±12.29 years. Patients were divided into two groups: patients with AKI and without AKI according to Acute Kidney Injury Network criteria. All patients had undergone cranial, carotid, and vertebral artery evaluation with magnetic resonance imaging. The number of patients with AKI was 14 (10.9%). Subjects experiencing atrial fibrillation (P=0.043) and higher diastolic blood pressure (DBP) (P=0.032) treated with mannitol (P=0.019) and furosemide (P=0.019) disclosed significant association with AKI. Regression analysis revealed that higher DBP (P=0.029) and management with mannitol (P=0.044) were the risk factors for AKI. Higher DBP at admission is the most important risk factor for AKI. However antiedema therapy should be used carefully in patients with acute ischemic stroke. Serum creatinine levels or estimated glomerular filtration rate should be watched frequently to prevent AKI. PMID:24570596

Micozkadioglu, Hasan

2014-01-01

44

Higher diastolic blood pressure at admission and antiedema therapy is associated with acute kidney injury in acute ischemic stroke patients  

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Full Text Available Hasan Micozkadioglu Department of Nephrology, Faculty of Medicine Hospital of Adana, Baskent University School of Medicine, Adana, Turkey Abstract: Antiedema therapy with mannitol and furosemide is widely used for prevention and management of cerebral edema, elevated intracranial pressure, and cerebral hernia. There are some reports about mannitol and furosemide as risk factors of acute kidney injury (AKI. We investigated the risk factors for AKI including antiedema therapy in acute ischemic stroke patients. The subjects were 129 patients with acute ischemic stroke including 56 females and 73 males with a mean age 68.16±12.29 years. Patients were divided into two groups: patients with AKI and without AKI according to Acute Kidney Injury Network criteria. All patients had undergone cranial, carotid, and vertebral artery evaluation with magnetic resonance imaging. The number of patients with AKI was 14 (10.9%. Subjects experiencing atrial fibrillation (P=0.043 and higher diastolic blood pressure (DBP (P=0.032 treated with mannitol (P=0.019 and furosemide (P=0.019 disclosed significant association with AKI. Regression analysis revealed that higher DBP (P=0.029 and management with mannitol (P=0.044 were the risk factors for AKI. Higher DBP at admission is the most important risk factor for AKI. However antiedema therapy should be used carefully in patients with acute ischemic stroke. Serum creatinine levels or estimated glomerular filtration rate should be watched frequently to prevent AKI. Keywords: furosemide, mannitol, renal failure, cerebrovascular disease

Micozkadioglu H

2014-02-01

45

Arterial blood pressure measurement and pulse wave analysis—their role in enhancing cardiovascular assessment  

International Nuclear Information System (INIS)

The most common method of clinical measurement of arterial blood pressure is by means of the cuff sphygmomanometer. This instrument has provided fundamental quantitative information on arterial pressure in individual subjects and in populations and facilitated estimation of cardiovascular risk related to levels of blood pressure obtained from the brachial cuff. Although the measurement is taken in a peripheral limb, the values are generally assumed to reflect the pressure throughout the arterial tree in large conduit arteries. Since the arterial pressure pulse becomes modified as it travels away from the heart towards the periphery, this is generally true for mean and diastolic pressure, but not for systolic pressure, and so pulse pressure. The relationship between central and peripheral pulse pressure depends on propagation characteristics of arteries. Hence, while the sphygmomanometer gives values of two single points on the pressure wave (systolic and diastolic pressure), there is additional information that can be obtained from the time-varying pulse waveform that enables an improved quantification of the systolic load on the heart and other central organs. This topical review will assess techniques of pressure measurement that relate to the use of the cuff sphygmomanometer and to the non-invasive registration and analysis of the peripheral and central arterial pressure waveform. Improved assessment of cardiovascular function in relation to treatment and management of high blood pressure will result from future developments in the indirect measurement of arterial blood pressure that involve the conventional cuff sphygmomanometer with the addition of information derived from the peripheral arterial pulse. (topical review)

46

Mechanism of depressed left ventricular early diastolic filling in patients with coronary artery disease  

International Nuclear Information System (INIS)

Multigated blood pool imaging with Tc-99m were obtained at rest at modified LAO. LV was divided from its geometric center and regional time activity curves (TACs) at septal (LAD distribution) and postero-lateral (non-ischemic) regions were obtained as well as global TACs. From global and regional TACs, global filling rate (1/3 FRm) and regional filling rate (R-FR) were calculated during the first third of diastole of each TAC. Patients with CAD were divided into Group I (n=10, without myocardial infarction) and Group II (n=8, with old anterior infarction). In Group II, reduced septal regional EF was observed and it was accompanied with compensatory augumentation of postero-lateral regional EF. In both CAD groups, global 1/3 FRm and septal R-FR reduced significantly compared with those of normal subjects(Septal R-FR; 2.15+-0.38 sec-1 in normal subjects, 1.49+-0.26 sec-1 in Group I, 1.72+-0.19 sec-1 in Group II), but postero-lateral R-FRs were not different from normal subjects. In Group II, end-ejection in the septal region delayed strikingly (50+-25 msec) and when R-FR was calculated at the same timing as global 1/3 FRm, it reduced significantly (0.83+-0.32 sec-1). But in Group I, delay of septal end-ejection was minimal (15+-13 msec) and R-FR did not change when it was measured at the same timing as global 1/3 FRm. These results suggest followings; in Group II, reduced LV early diastolic filling were caused by asynchronous LV filling as well as impaired diastolic filling of diseased myocardium, while in Group I, it was caused by reduced diastolic filling itself. Besides, no compensatory augumentation of diastolic filling in nonischemic myocardium may be a cause of early appearance of reduced diastolic filling in patients with CAD. (J.P.N.)

47

Working tension and arterial pressure  

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Full Text Available The working tension has been pointed out in recent years by its deleterious effects on the health. There are evidences of their interrelationnot only with hypertension, but with the cardiovascular illnesses in general, from there our interest in studying it.To determine the measure of associations between work types and the presence of arterial hypertension. 2 To value the moderator paper ofthe individual disposition in the confrontation of work demands and it’s control over the arterial pressure and their control.A descriptive traverse study was carried out. 256 workers were studied, two groups were conformed: hypertensive (148 and non hypertensive(108. A blood pressure measurement was done and the Questionnaire of Working Tension (based on the perception of the work andthe preferences was applied.The perception of nervous tension at the work position was significantly higher among hypertensive and particularly in non controlled ones(p <0,05. The high tension work behaved as a risk factor of hypertension (OR – 2,25 [1,22 – 4,17] p <0,05 and of not to control the sameone (OR – 2,20 [1,05-4,60] p <0,05. The agreement proportion among perceived and preferred work was low 0,267, evidencing, those interviewed,the necessity of lower levels of demand.The high tension work and the nervous tension acts as factors of psychological risk, influencing the control of the arterial hypertension. Thework of low tension is valued as the favorite one.

Miriam C. Peña Betancourt

2011-01-01

48

Determinantes clínicos de la presión de fin de diástole / Clinical determining factors of the end of diastole's pressure  

Scientific Electronic Library Online (English)

Full Text Available SciELO Colombia | Language: Spanish Abstract in spanish Introducción: la falla cardiaca sobreviene a los pacientes con múltiples enfermedades cardiovasculares. Se encuentra con frecuencia, que algunos pacientes no empeoran su clase funcional, a pesar de reunir condiciones clínicas que suponen una severa alteración fisiopatológica. Estos hallazgos son con [...] firmados al medir la presión de fin de diástole (PFD) en el laboratorio de hemodinamia. Objetivo: determinar qué factores clínicos inciden en la PFD. Material y métodos: estudio retrospectivo, descriptivo de 200 pacientes estudiados (muestra aleatoria de 1730 pacientes) durante el año 2005, con análisis de las relaciones entre la variable dependiente PFD y las variables independientes: edad, sexo, peso, superficie corporal, factores de riesgo, cuadro clínico, fracción de eyección (FE), alteraciones estructurales ventriculares (dilatación o hipertrofia), compromiso coronario (uno, dos o tres vasos, angiográficamente sanos, o presencia de flujo lento intracoronario), y la arteria coronaria comprometida. Se aplicó un modelo de regresión lineal simple mediante el paquete estadístico STATA Versión 9. Resultados: las variaciones de aumento de la PFD están relacionadas con: hipertensión arterial (HTA), dilatación ventricular izquierda, mayor compromiso coronario (tres vasos) y presencia de ateromatosis significativa de las arterias descendente anterior y coronaria derecha. Las variaciones decrecientes de la PFD se presentaron ante el aumento de la FE y la presencia de arterias sanas. Conclusiones: se confirman algunos factores conocidos que inciden sobre la PFD, pero sorprende la ausencia de cambios significativos de la PFD ante cuadros clínicos más inestables y ante la presencia de hipertrofia. Este estudio provee elementos significativos para futuras investigaciones clínicas en el campo. Abstract in english Abstract Introduction: many cardiovascular diseases may cause heart failure, because of impairment of systolic or diastolic function, or both. It is frequently observed that regardless of physiopathological processes that were presumed to cause major symptoms, some patients have normal or quite norm [...] al functional class of dyspnea. This observation is sometimes confirmed in the cath lab, when the measured end diastolic pressure (EDP) is normal. Objective: to study which clinical factors are related with changes in EDP. Methods: 200 patients were included in a sample of 1.730 patients studied in the Cath Lab during 2005. This retrospective, descriptive and analytic study seeked for association between EDP and independent variables such as: age, sex gender, weight, clinical risk factor for coronary artery disease, the clinical presentation, ejection fraction (EF) measured, structural changes in left ventricle morphology (dilatation or hypertrophy), extent of coronary disease (one, two or three-vessel disease, normal coronaries, or reduced intracoronary flow), and the coronary artery involved. Statistically, a simple linear regression model was applied in the STATA 9 program. Results: increasing variability in the EDP was found to be significantly related with: hypertension, dilated left ventricle, 3-vessel disease, left coronary descendant and right coronary artery involvement. Decreasing variability of EDP presented with increasing EF and normal coronary arteries. Conclusions: some clinical factors were confirmed as related with altered EDP, but others, such as the more unstable clinical conditions and hypertrophy, surprisingly showed no significant relation with EDP variations. This investigation offers new pathways to future clinical studies in this area.

Luis Miguel, Benítez; José Vicente, Narváez.

2007-09-15

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Determinantes clínicos de la presión de fin de diástole Clinical determining factors of the end of diastole's pressure  

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Full Text Available Introducción: la falla cardiaca sobreviene a los pacientes con múltiples enfermedades cardiovasculares. Se encuentra con frecuencia, que algunos pacientes no empeoran su clase funcional, a pesar de reunir condiciones clínicas que suponen una severa alteración fisiopatológica. Estos hallazgos son confirmados al medir la presión de fin de diástole (PFD en el laboratorio de hemodinamia. Objetivo: determinar qué factores clínicos inciden en la PFD. Material y métodos: estudio retrospectivo, descriptivo de 200 pacientes estudiados (muestra aleatoria de 1730 pacientes durante el año 2005, con análisis de las relaciones entre la variable dependiente PFD y las variables independientes: edad, sexo, peso, superficie corporal, factores de riesgo, cuadro clínico, fracción de eyección (FE, alteraciones estructurales ventriculares (dilatación o hipertrofia, compromiso coronario (uno, dos o tres vasos, angiográficamente sanos, o presencia de flujo lento intracoronario, y la arteria coronaria comprometida. Se aplicó un modelo de regresión lineal simple mediante el paquete estadístico STATA Versión 9. Resultados: las variaciones de aumento de la PFD están relacionadas con: hipertensión arterial (HTA, dilatación ventricular izquierda, mayor compromiso coronario (tres vasos y presencia de ateromatosis significativa de las arterias descendente anterior y coronaria derecha. Las variaciones decrecientes de la PFD se presentaron ante el aumento de la FE y la presencia de arterias sanas. Conclusiones: se confirman algunos factores conocidos que inciden sobre la PFD, pero sorprende la ausencia de cambios significativos de la PFD ante cuadros clínicos más inestables y ante la presencia de hipertrofia. Este estudio provee elementos significativos para futuras investigaciones clínicas en el campo.Abstract Introduction: many cardiovascular diseases may cause heart failure, because of impairment of systolic or diastolic function, or both. It is frequently observed that regardless of physiopathological processes that were presumed to cause major symptoms, some patients have normal or quite normal functional class of dyspnea. This observation is sometimes confirmed in the cath lab, when the measured end diastolic pressure (EDP is normal. Objective: to study which clinical factors are related with changes in EDP. Methods: 200 patients were included in a sample of 1.730 patients studied in the Cath Lab during 2005. This retrospective, descriptive and analytic study seeked for association between EDP and independent variables such as: age, sex gender, weight, clinical risk factor for coronary artery disease, the clinical presentation, ejection fraction (EF measured, structural changes in left ventricle morphology (dilatation or hypertrophy, extent of coronary disease (one, two or three-vessel disease, normal coronaries, or reduced intracoronary flow, and the coronary artery involved. Statistically, a simple linear regression model was applied in the STATA 9 program. Results: increasing variability in the EDP was found to be significantly related with: hypertension, dilated left ventricle, 3-vessel disease, left coronary descendant and right coronary artery involvement. Decreasing variability of EDP presented with increasing EF and normal coronary arteries. Conclusions: some clinical factors were confirmed as related with altered EDP, but others, such as the more unstable clinical conditions and hypertrophy, surprisingly showed no significant relation with EDP variations. This investigation offers new pathways to future clinical studies in this area.

Luis Miguel Benítez

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Spectral analysis of heart rate and arterial pressure variability after nitric oxide synthase inhibition.  

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The experiments were performed on male, conscious Wistar rats. Femoral arterial pressure was registered by Statham GOULD P23 ID pressure transducer connected to MP 100WS BIOPAC work station after analog to digital conversion during 40 minutes long control period. Nitric oxide synthase inhibition was performed by injection of 100 microliters, 10 mg/kg b.w. N-omega-nitro-L-arginine methyl ester (L-NAME) in saline through femoral vein catheter. Twenty minutes later arterial pressure registration was started and was continued for 40 minutes. The pulse-by-pulse values of systolic, diastolic and mean arterial pressure as well as the pulse intervals were measured by peak and rate detectors of the AcqKnowledge 2.0 software. Row data were processed using a virtual instrument developed in our laboratory in the graphical programming environment Lab VIEW 3.1.1. L-NAME increased systolic, diastolic and mean arterial pressure by 16.6%, 25% and 35%, respectively. The PMF/PHF ratio in heart rate spectrum decreased, indicating an increased vagal effect on the heart. Nitric oxide synthase inhibition increased the low-frequency component of systolic arterial blood pressure variability by 39.5%. Nitric oxide is a physiological regulator of rapid fluctuations of arterial blood pressure. PMID:10672333

Mikhov, D; Markova, P; Girchev, R

1998-01-01

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Right ventricular systolic and diastolic function at rest in patients with coronary artery disease  

International Nuclear Information System (INIS)

Right ventricular systolic and diastolic function was studied in patients with ischemic heart disease using equilibrium radionuclide ventriculography. In patients with inferior myocardial infarction and proximal right coronary lesions, the right ventricular ejection fraction (0.43+-0.06, n=10, mean+-SD) and peak filling rate (1.7+-0.4 EDV/sec) were lower than normals (0.57+-0.07 and 2.7+-0.4 EDV/sec, n=10, p<0.001, respectively). In these patients, the right ventricular time to peak filling rate was longer than in normals (225+-36 msec vs 136+-45 msec, p<0.001), while the left ventricular ejection fraction remained normal. In patients with inferior myocardial infarction and distal right coronary lesions, the right ventricular ejection fraction, peak filling rate and time to peak filling rate were not different from those in normals. Even in patients with proximal right coronary lesions, the right ventricular ejection fraction was normal unless they had an inferior myocardial infarction. A decreased left ventricular ejection fraction and abnormal motion of the ventricular septum did not affect the right ventricular ejection fraction. The present results suggest that patients with an inferior myocardial infarction and proximal right coronary lesion often develop right ventricular systolic and diastolic dysfunction. (author)

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Diastolic function and functional capacity after a single session of continuous positive airway pressure in patients with compensated heart failure  

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Full Text Available SciELO Brazil | Language: English Abstract in english OBJECTIVE: The effects of acute continuous positive airway pressure therapy on left ventricular diastolic function and functional capacity in patients with compensated systolic heart failure remain unclear. METHODS: This randomized, double-blind, placebo-controlled clinical trial included 43 pati [...] ents with heart failure and a left ventricular ejection fraction

Marjory Fernanda, Bussoni; Gabriel Negretti, Guirado; Luiz Shiguero, Matsubara; Meliza Goi, Roscani; Bertha Furlan, Polegato; Suzana Tanni, Minamoto; Silméia Garcia Zanati, Bazan; Beatriz Bojikian, Matsubara.

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Differences in circadian time structure of diastolic blood pressure between diabetes mellitus and essential hypertension  

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Full Text Available Abstract Background Abnormal circadian blood pressure patterns have been associated with cardiovascular disease in diabetes mellitus. We have described that the acrophase of diastolic blood pressure (DBP registered in type 1 diabetes (T1D patients was significantly earlier than normal and DBP ecphasia was more pronounced in patients with lower heart rate variability during deep breathing. The aim of this study was to compare the circadian rhythm characteristics of BP among different groups: normotensive (NT control subjects, patients affected by T1D and type 2 diabetes (T2D, and patients with essential hypertension (HT. Findings We retrospectively evaluated ambulatory blood pressure monitoring records in 30 NT, 20 T1D, 20 T2D, 20 HT whose fasting plasma glucose and HbA1c were contemporaneously measured. The four groups were well-matched regarding age, gender, and BMI. Systolic blood pressure (SBP and DBP midline-estimating statistic of rhythm were higher in T1D, T2D, and HT groups. DBP ecphasia was present only in the diabetic individuals: the acrophase of DBP occurred four hours earlier than normal in T1D group, whereas two hours earlier in T2D group. In a multiple regression analysis, only HbA1c and SBP acrophase were statistically significant correlates of DBP acrophase. Conclusions People with diabetes mellitus, both type 1 and type 2, have their circadian acrophase of DBP occurring 2–4 hours earlier than normotensive and hypertensive subjects. Altered circadian timing of DBP, potential trigger of cardiovascular events, seems to be a distinguishing feature of diabetes mellitus and correlates with the previous 2–3 months of glycaemic control.

Matteucci Elena

2012-12-01

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Correlation of femoral artery vs radial artery pressures with central pressure after cardiopulmonary bypass in children  

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To assess the effectiveness of femoral and radial arterial lines on the correlation of peripheral and central mean arterial blood pressure in children after discontinuation of cardiopulmonary bypass. Fifty children scheduled for cardiac surgery with cardiopulmonary bypass were included in the study. After approval from the hospital ethics committee and informed consent. 50 children undergoing cardiac surgical procedures with cardiopulmonary bypass were randomly assigned to two different groups. In Group- A (RAP, n-2) a radial arterial line and in Group-B (FAP, n-25) a femoral arterial line was used to monitor the blood pressure. Simultaneous mean peripheral arterial pressure and mean central aortic pressure were recorded before cardiopulmonary bypass and 5 mins after separation from the cardiopulmonary bypass. The correlation of mean peripheral arterial pressure (radial and femoral) versus mean aortic pressure were compared. The data was recorded as Mean +- SD and P-value. The ages of children ranged from 4-12 years and their weight from 14.1-28.5 kg. In all of them following cardiopulmonary bypass, aortic pressure correlates better with femoral arterial pressure (p<0.001). The radial arterial line readings under estimated central aortic pressure when compared to femoral arterial line readings. Aortic pressure readings correlate better with femoral arterial pressure than radial arterial pressure in children. (author)

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Increased reactive oxygen species, metabolic maladaptation, and autophagy contribute to pulmonary arterial hypertension-induced ventricular hypertrophy and diastolic heart failure.  

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Pulmonary arterial hypertension (PAH) is a debilitating and deadly disease with no known cure. Heart failure is a major comorbidity and a common cause of the premature death of patients with PAH. Increased asymmetrical right ventricular hypertrophy and septal wall thickening compress the left ventricular cavity and elicit diastolic heart failure. In this study, we used the Sugen5416/hypoxia/normoxia-induced PAH rat to determine whether altered pyridine nucleotide signaling in the failing heart contributes to 1) increased oxidative stress, 2) changes in metabolic phenotype, 3) autophagy, and 4) the PAH-induced failure. We found that increased reactive oxygen species, metabolic maladaptation, and autophagy contributed to the pathogenesis of right ventricular remodeling and hypertrophy that lead to left ventricular diastolic dysfunction. In addition, arterial elastance increased in PAH rats. Glucose-6-phosphate dehydrogenase is a major source of pyridine molecule (nicotinamide adenine dinucleotide phosphate), which is a substrate for nicotinamide adenine dinucleotide phosphate oxidases in the heart. Dehydroepiandrosterone, a 17-ketosteroid that reduces pulmonary hypertension and right ventricular hypertrophy, inhibited glucose-6-phosphate dehydrogenase, decreased oxidative stress, increased glucose oxidation and acetyl-coA, and reduced autophagy in the hearts of PAH rats. It also decreased arterial stiffness and improved left ventricular diastolic function. These findings demonstrate that pyridine nucleotide signaling, at least partly, mediates PAH-induced diastolic heart failure, and that reduction of glucose-6-phosphate dehydrogenase-derived nicotinamide adenine dinucleotide phosphate is beneficial to improve left ventricle diastolic function. PMID:25267798

Rawat, Dhawjbahadur K; Alzoubi, Abdallah; Gupte, Rakhee; Chettimada, Sukrutha; Watanabe, Makino; Kahn, Andrea G; Okada, Takao; McMurtry, Ivan F; Gupte, Sachin A

2014-12-01

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Evaluation of mild coronary artery disease through the analysis of left ventricular diastolic phase indicies obtained from S/sub 2/-gated equilibrium scintigraphy  

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S/sub 2/-gated equilibrium scintigraphs were made for a control group (5 subjects ) and a patient group (21 subjects) with mild coronary artery disease and LVEF greater than 50% at rest. Four LV diastolic phase indices (PEAK, PEAK TIME, SHIFT, and R-RATIO) were derived from the scintigraphs as follows. The deviation of the disastolic phase volume curve from the SIN curve was used as an early diastolic phase index. The PEAK measures the maximum deviation; the PEAK TIME measures the time from the start of diastole to the PEAK; the SHIFT measures the phase deviation between the two curves at the mid-point of diastole. As an index of left atrial systolic function, the ratio of the deviation area of the early diastolic phase (R) to the deviation area of the early plus the late diastolic phases (R+A) was derived and referred to as the R-RATIO ((R/(R+A)). The cardiac reserve was then evaluated from these four indices. The patient group was further divided into an LVEF increase group and an LVEF decrease group according to the results of an exercise test. No difference was found in the systolic and diastolic functions between the control group and the increase group leading us to consider that their LV functions are identical. The decrease group, when compared to the control and increase groups, was found to have a rapid filling phase dysfunction which was compensated by the left atrial systolic function. From the use of these new diastolic phase indices in the above analysis, a slight decrease in the cardiac reserve of patients with mild coronary artery disease was observed for the systolic function during exercise.

Shiraishi, Tomokuni; Kobayashi, Akitoshi; Hasegawa, Takeo; Nishiyama, Yutaka; Nakazawa, Midori; Tanaka, Yoshimasa (Kansai Medical School, Moriguchi, Osaka (Japan))

1984-06-01

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Serum cholesterol and LDL-C in association with level of diastolic blood pressure in type 2 diabetic patients  

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Introduction: Elevated cholesterol and blood pressure are major risk factors for the development diabetic kidney disease. Possible interactions between these two parameters have not been studied in detail. Objectives: This investigation aims to study the values of blood serum cholesterol, blood pressure and possible correlations between them, in a group of type 2 diabetic (T2D) patients. Patients and Methods: A total of 60 patients with T2D were enrolled to the study. Venous blood samples were obtained in the fasting state for determinations of serum creatinine, lipids and hemoglobin A1C (HbA1c). Results: Of 60 participants, Mean of age was 57±8.3 years. Mean of systolic and diastolic blood pressure was 133±13 mmHg and 84±7.4 mmHg respectively. Mean of serum cholesterol and LDL-C was 182±34.5 mg/dl and 97.2 ±27.9 mg/dl respectively. In this study, a significant positive correlation of serum cholesterol with level of diastolic blood pressure (r= 0.286, p=0.030) was seen (adjusted for duration of diabetes and weight). Furthermore a significant positive correlation of serum LDL-C with level of diastolic blood pressure (r= 0.263, p= 0.044) was seen (adjusted for age). Conclusion: We found a significant inverse correlation of serum cholesterol and LDL-C with level of diastolic blood pressure. This study showed the influence of serum lipids on the development of hypertension and further support the control of dyslipidemia, to prevent diabetic kidney disease.

Behradmanesh, Saeed; Nasri, Parto

2012-01-01

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Relação entre gordura corporal e pressão arterial sistólica e diastólica em escolares entre 14 e 17 anos de Floriano-Piauí-Brasil / Relationship between body fat and systolic and diastolic blood pressure in students between 14 and 17 years of age in Floriano-Piauí-Brazil  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese As doenças cardiovasculares estão associadas ao estilo de vida. Com isso, este estudo tem como objetivo descrever e analisar a associação entre gordura corporal e pressão arterial sistólica entre escolares da cidade de Floriano-PI. Caracteriza-se como um estudo observacional de prevalência do tipo d [...] escritivo com delineamento de corte transversal. A população de estudo incluiu escolares com idade entre 14 e 17 anos, de ambos os sexos. Realizou-se análise descritiva de tendência central e dispersão, análise univariada e bivariada (com nível de significância de p?0,05). O índice de confiança considerado foi de 95%. Os principais resultados demonstram altas taxas de gordura corporal (51,1%) e de hipertensão arterial (18%) para os escolares, além de associação positiva significativa entre pressão arterial sistólica e gordura corporal entre os escolares do sexo feminino. Conclui-se que os escolares de Floriano apresentam fatores de riscos para o desenvolvimento de doenças crônicas não transmissíveis. Abstract in english Cardiovascular diseases are associated with lifestyle. Thus, this study aimed to describe and analyze the association between body fat and systolic blood pressure among schoolchildren in the city of Floriano-PI. It can be characterized as an observational study of prevalence with a descriptive, cros [...] s-sectional design. The study population included adolescents aged between 14 and 17 years, of both sexes. We conducted a descriptive analysis of central tendency and dispersion, with one- and two-way analysis (significance level p

Irineu de, Sousa Júnior; Márcia Cristiane, Araújo; Nanci Maria de, França.

2013-09-01

59

[The arterial pressure problem in dental practice].  

Science.gov (United States)

High blood pressure (hypertension) is one the most frequent problems, especially for older patients in Europe. Often hypertension has no symptoms, therefore it is called a "Silent Killer". The morbidity and mortality is high among the population. This provides important significance for diagnosis and treatment of hypertension. In the USA and the Netherlands screening of blood pressure during dental check-ups was studied. It became well-known that blood pressure increases more in hypertensive patients than in controls. Before check-up increase is about 8 mm Hg, but during treatment without a local anesthesia and during extraction under a local anesthesia there is a significant sudden increase. Therefore it is important to define patients physical status including blood pressure, in ASA risk score. This allows to take preventive measures during dental treatment in patients with a systolic blood pressure between 160 - 200 mm Hg and diastolic 95 - 115 mm Hg. A systolic blood pressure > 200 mm Hg and diastolic > 115 mm Hg is an absolute contraindication to dental procedure. PMID:8658572

Abraham-Inpyain, L; Polsacheva, O V; Gortzak, R A

1996-01-01

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Feasibility of using finger arterial pressure in neonates  

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The feasibility of using a Finapres device to reproduce the beat to beat signal of arterial blood pressure in eight neonates was assessed and compared with intra-arterial measurement of arterial blood pressure in the umbilical artery, using a catheter. The two methods gave similar results. Continuous recording of arterial blood pressure in neonates using Finapres is feasible and reliable.?? Keywords: blood pressure monitoring; Finapres; umbilical artery

Drouin, E.; Gournay, V.; Calamel, J.; Mouzard, A.; Roze, J.

1997-01-01

 
 
 
 
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La hipertensión arterial en la tercera edad High blood pressure in third age  

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Full Text Available A partir de la quinta o sexta décadas de la vida, la hipertensión arterial adopta formas y obedece a causas diferentes a las del niño o a las del adulto joven. En este caso, la presión arterial sistólica aumenta (> 140 mmHg y la diastólica se mantiene o disminuye (From the fifth or sixth decades of life, high blood pressure adopts ways and is due to different causes to that of child or to that of young adult. In this case, systolic arterial pressure increases (> 140 mmHg, and the diastolic one remains or decreases (< 90 mmHg, and differential pressure increases. The cause is conduction artery stiffness by atherosclerosis as well as the action of some hormones including: adrenaline, noradrenaline, agiotensin II, and aldosterone on the arterial medium wall. Diagnosis is made verifying presence of an isolated systolic high blood pressure in patients aged over 50. In youngest, in addition to high systolic pressure with a normal or low diastolic pressure, it is advisable measurement of others indicators of aortic stiffness. Systolic pressure in third age may to be associated with: left ventricular and arterial hypertrophy, a relaxation decrease of cardiac and coronary walls, myocardial ischemia, nephroesclerosis, cognitive decline or even dementia. Treatment requires special cares and must to adjust to the frequent morbidity of old age. The more effective antihypertensive groups according to randomized assays include: agiotensin-converting enzyme (ACE inhibitors, agiotensin II blockers, aldosterone antagonists, and calcium blockers. Nitrates and diuretic agents have been used to reduce systolic pressure, especially when there is an aortic valvular regurgitation. Decrease of systolic pressure to result in a delay or an arrest of cardiovascular complications, of cognitive decline, and dementia in third age patients.

David García Barreto

2009-06-01

62

Non-Invasive Assessment of Left Ventricular End-Diastolic Pressure in Patients with Chronic Aortic Regurgitation, Comparison of the Sensitivity and Specificity of CW Doppler Echocardiography with Angiography  

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Full Text Available Background: Left ventricular end diastolic pressure could be estimated collectively using various measures of mitral valve and pulmonary venous flow velocities. In patients with aortic regurgitation, the AR velocity reflects the diastolic pressure difference between the aorta and the left ventricle. We sought to predict the left ventricular end diastolic pressure by a new Doppler index as aortic regurgitation peak early to late diastolic pressure gradient ratio.Patients and Methods: Fifty three patients with at least moderate aortic regurgitation were enrolled in this study. Physical examination, electrocardiography and echocardiography were performed one day before cardiac catheterization. The severity of AR was graded according to the recommendations of American society for echocardiography. The pressure half time, aortic regurgitation early diastolic velocity , aortic regurgitation early diastolic pressure gradient , aortic regurgitation end diastolic velocity, aortic regurgitation end diastolic pressure gradient, and early diastolic to end diastolic pressure gradient ratio of averaged three beats were measured and recorded. The results from cardiac catheterization and echocardiography were compared.Result: The early diastolic to end diastolic pressure gradient ratio was very accurate (80% for determining the left ventricular end diastolic pressure (P =0.01. An early diastolic to end diastolic pressure gradient ratio of 1.5 has a sensitivity of 96% and a specificity of 32% for left ventricular end diastolic pressure ?12 mmHg. The best cutoff value of early diastolic to end diastolic pressure gradient ratio for the prediction of left ventricular end diastolic pressure >12 mmHg was higher than 2.0, with a sensitivity of 71% and specificity of 96% We found no significant correlation between the left ventricular end diastolic pressure with either left ventricular ejection fraction or aortic regurgitation severity in cardiac catheterization (P =0.5.Conclusion: Doppler echocardiography is a viable alternative of cardiac catheterization for determination of the left ventricular end diastolic pressure. The early diastolic to end diastolic pressure gradient ratio is a simple, easy and new method for assessment of the LVEDP in patients with severe chronic aortic regurgitation.

M Esmaeilzadeh

2009-06-01

63

Investigation Of Arterial Blood Pressure Level And Metabolic Indices In Patients With Arterial Hypertension At Pharmacotherapy With Antihypertensive Medicines Of Various Chemical Structure  

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Full Text Available The research goal is to carry on the comparative analysis of medicines of various chemical structure, Telmisar-tan and Bisoprolol, and to reveal their effect on the arterial blood pressure level and the indices of various metabolic processes in patients with arterial hypertension. 60 out-patients with arterial hypertension (stage II risk III both males and females aged 33-55 have been under study taking Telmisartan and Bisoprolol for 3 months. While treating the patients the arterial blood pressure level control and biochemical investigations for determination the indices of metabolic processes have been carried out. The investigated medications have provided the decrease of systolic and diastolic arterial pressure parameters, the increase of concentration of total and ionized calcium, chlorine ions, urea and total bilirubin in blood plasma. Therapy with Telmisartan has shown more significant increase of potassium level in erythro-cytes, decrease of levels of natrium, glucose, glycolized hemoglobin and triglycerides and increased contents of alani-naminotransferase and aspartataminotransferase. The course of therapy with Bisoprolol has restored the normal level of magnesium in blood plasma, has not have any influence on carbohydrate and lipid metabolism, increased the level of alaninaminotransferase and significantly increased the contents of total and ionized calcium, urea and creatinine. 3-months therapy with Telmisartan and Bisoprolol has proved the decrease of systolic and diastolic arterial pressure in patients with arterial hypertension. The medications under study have had active and variable effects on metabolic indices

G.Kh. Glybochko

2009-12-01

64

Measurement of blood pressure using an arterial pulsimeter equipped with a Hall device.  

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To measure precise blood pressure (BP) and pulse rate without using a cuff, we have developed an arterial pulsimeter consisting of a small, portable apparatus incorporating a Hall device. Regression analysis of the pulse wave measured during testing of the arterial pulsimeter was conducted using two equations of the BP algorithm. The estimated values of BP obtained by the cuffless arterial pulsimeter over 5 s were compared with values obtained using electronic or liquid mercury BP meters. The standard deviation between the estimated values and the measured values for systolic and diastolic BP were 8.3 and 4.9, respectively, which are close to the range of values of the BP International Standard. Detailed analysis of the pulse wave measured by the cuffless radial artery pulsimeter by detecting changes in the magnetic field can be used to develop a new diagnostic algorithm for BP, which can be applied to new medical apparatus such as the radial artery pulsimeter. PMID:22319381

Lee, Sang-Suk; Nam, Dong-Hyun; Hong, You-Sik; Lee, Woo-Beom; Son, Il-Ho; Kim, Keun-Ho; Choi, Jong-Gu

2011-01-01

65

Ambulatory arterial blood pressure monitoring in patients before and after thyroidectomy  

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Full Text Available Bacground/Aim. Increased values of thyroid hormones in the clinical syndrome of hyperthyreosis affect blood pressure values and its circadial variation. The aim of this study was to define the influence of hyperthyreosis on the values and circadial variations of arterial blood pressure, as well as to investigate the effect of thyroid surgery on blood pressure values. Methods. We compared the 24-hour averages of systolic and diastolic blood pressure, their variations and their reduction during the night between 20 female patients with hyperthyroidism and hypertension de novo and 20 healthy females. We compared the values of 24-hour ambulatory monitoring performed before the surgery with the values gathered two weeks after the surgery. Results. The 24-hour average systolic and diastolic blood pressure values were higher in the patients with hyperthyroidism than in the control group (p < 0.001. In the group of patients, the variations in blood pressure were significantly higher than they were in the group of healthy people (p < 0.001. The amplitude of the nocturnal reduction of blood pressure was also significantly lower in the patients with hyperthyroid status and hypertension, in comparison to the healthy persons (p < 0.001. Two weeks after the surgery, a significant reduction of blood pressure values (both for systolic and diastolic appeared. Conclusion. The patients with hyperthyroidism- caused hypertension had higher systolic and diastolic blood pressure, higher variations in blood pressure and lower nocturnal reduction of blood pressure than healthy subjects. Thyroid surgery, as a control of thyroid function, optimised blood pressure very rapidly.

Ivanovi? Branislava

2008-01-01

66

Isometric handgrip training reduces arterial pressure at rest without changes in sympathetic nerve activity  

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The purpose of this study was to determine whether isometric handgrip (IHG) training reduces arterial pressure and whether reductions in muscle sympathetic nerve activity (MSNA) mediate this drop in arterial pressure. Normotensive subjects were assigned to training (n = 9), sham training (n = 7), or control (n = 8) groups. The training protocol consisted of four 3-min bouts of IHG exercise at 30% of maximal voluntary contraction (MVC) separated by 5-min rest periods. Training was performed four times per week for 5 wk. Subjects' resting arterial pressure and heart rate were measured three times on 3 consecutive days before and after training, with resting MSNA (peroneal nerve) recorded on the third day. Additionally, subjects performed IHG exercise at 30% of MVC to fatigue followed by muscle ischemia. In the trained group, resting diastolic (67 +/- 1 to 62 +/- 1 mmHg) and mean arterial pressure (86 +/- 1 to 82 +/- 1 mmHg) significantly decreased, whereas systolic arterial pressure (116 +/- 3 to 113 +/- 2 mmHg), heart rate (67 +/- 4 to 66 +/- 4 beats/min), and MSNA (14 +/- 2 to 15 +/- 2 bursts/min) did not significantly change following training. MSNA and cardiovascular responses to exercise and postexercise muscle ischemia were unchanged by training. There were no significant changes in any variables for the sham training and control groups. The results indicate that IHG training is an effective nonpharmacological intervention in lowering arterial pressure.

Ray, C. A.; Carrasco, D. I.

2000-01-01

67

Blood pressure, internal carotid artery flow parameters, and age-related white matter hyperintensities.  

Science.gov (United States)

White matter hyperintensities (WMH) are associated with hypertension. We examined interactions among blood pressure (BP), internal carotid artery (ICA) flow velocity parameters, and WMH. We obtained BP measurements from 694 community-dwelling subjects at mean ages 69.6 (±0.8) years and again at 72.6 (±0.7) years, plus brain MRI and ICA ultrasound at age 73±1 years. Diastolic and mean BP decreased and pulse pressure increased, but systolic BP did not change between 70 and 73 years. Multiple linear regression, corrected for vascular disease and risk factors, showed that WMH at the age of 73 years were associated with history of hypertension (?=0.13; Page of 70 years (systolic ?=0.08, mean ?=0.09, diastolic ?=0.08; all Page of 73 years. Lower diastolic BP and higher pulse pressure were associated with higher ICA pulsatility index at the age 73 years (diastolic BP age 70 years: standardized ?=-0.24, Page 70 years: ?=0.19, Page and stiffer vessels, or both. Reducing vascular stiffness may reduce WMH progression and should be tested in randomized trials, in addition to testing antihypertensive therapy. PMID:24470459

Aribisala, Benjamin S; Morris, Zoe; Eadie, Elizabeth; Thomas, Avril; Gow, Alan; Valdés Hernández, Maria C; Royle, Natalie A; Bastin, Mark E; Starr, John; Deary, Ian J; Wardlaw, Joanna M

2014-05-01

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Heart rate variability in diastolic dysfunction and diastolic heart failure  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Reduced heart rate variability (HRV) is associated with increased morbidity and mortality in patients with systolic heart failure (HF). So far available data regarding the prognostic significance of HRV in diastolic heart failure is insufficient. We prospectively analyzed HRV in pts. with diastolic dysfunction (DD) with or without diastolic HF. Pts. aged 50 to 85 years with at least one of the following diagnoses were included: arterial hypertension, diabetes mellitus, manifestation of athero...

Schimpf, Klaus

2013-01-01

69

Plasma advanced glycation end products (AGEs) and NF-?B activity are independent determinants of diastolic and pulse pressure  

DEFF Research Database (Denmark)

Abstract Background: High levels of circulating advanced glycation end products (AGEs) can initiate chronic low-grade activation of the immune system (CLAIS) with each of these factors independently associated with cardiovascular (CV) morbidity and mortality. Therefore, our objective was to characterize the relationship between serum AGEs, CLAIS and other risk factors for CV disease in normotensive non-diabetic individuals. Methods: We measured body mass index (BMI), waist-to-hip ratio (WHR), blood pressure, lipid and glucose profile in 44 non-diabetic volunteers (17 female, 27 males). Carboxymethyl-lysine (CML) was measured by ELISA as a marker for circulating AGEs and NF-?B p65 activity as an inflammatory marker by DNA-binding in peripheral blood mononuclear cells lysates (PBMC). Results: Plasma CML concentrations were related to diastolic blood pressure (r=-0.51, p

Sourris, Karly C; Lyons, Jasmine G

2013-01-01

70

Pressão arterial em adolescentes durante teste ergométrico Arterial blood pressure in adolescents during exercise stress testing  

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Full Text Available OBJETIVO: Descrever a resposta da pressão arterial em adolescentes submetidos ao teste de esforço. MÉTODOS: Foi realizado estudo transversal de 218 adolescentes entre 10 e 19 anos (131 do sexo masculino submetidos a teste ergométrico, e descrita a freqüência cardíaca máxima, tempo de exercício, consumo máximo de oxigênio, pressão arterial sistólica (PAS e diastólica (PAD de repouso, no esforço máximo e aos seis minutos da recuperação. RESULTADOS: No repouso, a PAS teve valores maiores no sexo masculino e a PAD não mostrou diferença entre os sexos, porém ambas aumentaram com a idade. No exercício ocorreu elevação da PAS e queda da PAD em ambos os sexos. A variação da PAS foi maior no sexo masculino, principalmente acima dos 14 anos. CONCLUSÃO: A análise dos resultados demonstrou que a PAS durante o exercício teve relação direta com idade, peso, altura e índice de massa corpórea do indivíduo e a PAD teve relação apenas com a idade.OBJECTIVE: Describe arterial blood pressure response in adolescents undergoing exercise stress testing. METHODS: This was a cross-sectional study conducted with 218 adolescents (131 of whom were males, aged between 10 to 19 years, undergoing exercise stress testing. Maximum heart rate, total exercise time, maximum oxygen uptake, systolic blood pressure (SBP and diastolic (DBP at rest, during maximal physical exertion and at six minutes of recovery were measured. RESULTS: At rest, SBP values were greater in males and no difference was found in DBP between genders, although both increased with age. During exercise, SBP rose and DBP fell in both genders. SBP variation was greater in men, particularly in those over 14 years of age. CONCLUSION: Analysis of results showed that during physical exercise, SBP had a direct relationship with the individual’s age, weight, height and body mass index, whereas DBP bore a relationship to age only.

Mônica de Moraes Chaves Becker

2007-03-01

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Pressão arterial em adolescentes durante teste ergométrico / Arterial blood pressure in adolescents during exercise stress testing  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese OBJETIVO: Descrever a resposta da pressão arterial em adolescentes submetidos ao teste de esforço. MÉTODOS: Foi realizado estudo transversal de 218 adolescentes entre 10 e 19 anos (131 do sexo masculino) submetidos a teste ergométrico, e descrita a freqüência cardíaca máxima, tempo de exercício, con [...] sumo máximo de oxigênio, pressão arterial sistólica (PAS) e diastólica (PAD) de repouso, no esforço máximo e aos seis minutos da recuperação. RESULTADOS: No repouso, a PAS teve valores maiores no sexo masculino e a PAD não mostrou diferença entre os sexos, porém ambas aumentaram com a idade. No exercício ocorreu elevação da PAS e queda da PAD em ambos os sexos. A variação da PAS foi maior no sexo masculino, principalmente acima dos 14 anos. CONCLUSÃO: A análise dos resultados demonstrou que a PAS durante o exercício teve relação direta com idade, peso, altura e índice de massa corpórea do indivíduo e a PAD teve relação apenas com a idade. Abstract in english OBJECTIVE: Describe arterial blood pressure response in adolescents undergoing exercise stress testing. METHODS: This was a cross-sectional study conducted with 218 adolescents (131 of whom were males), aged between 10 to 19 years, undergoing exercise stress testing. Maximum heart rate, total exerci [...] se time, maximum oxygen uptake, systolic blood pressure (SBP) and diastolic (DBP) at rest, during maximal physical exertion and at six minutes of recovery were measured. RESULTS: At rest, SBP values were greater in males and no difference was found in DBP between genders, although both increased with age. During exercise, SBP rose and DBP fell in both genders. SBP variation was greater in men, particularly in those over 14 years of age. CONCLUSION: Analysis of results showed that during physical exercise, SBP had a direct relationship with the individual’s age, weight, height and body mass index, whereas DBP bore a relationship to age only.

Mônica de Moraes Chaves, Becker; Odwaldo Barbosa e, Silva; Isaura Elaine Gonçalves, Moreira; Edgar Guimarães, Victor.

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Strength training reduces arterial blood pressure but not sympathetic neural activity in young normotensive subjects  

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The effects of resistance training on arterial blood pressure and muscle sympathetic nerve activity (MSNA) at rest have not been established. Although endurance training is commonly recommended to lower arterial blood pressure, it is not known whether similar adaptations occur with resistance training. Therefore, we tested the hypothesis that whole body resistance training reduces arterial blood pressure at rest, with concomitant reductions in MSNA. Twelve young [21 +/- 0.3 (SE) yr] subjects underwent a program of whole body resistance training 3 days/wk for 8 wk. Resting arterial blood pressure (n = 12; automated sphygmomanometer) and MSNA (n = 8; peroneal nerve microneurography) were measured during a 5-min period of supine rest before and after exercise training. Thirteen additional young (21 +/- 0.8 yr) subjects served as controls. Resistance training significantly increased one-repetition maximum values in all trained muscle groups (P < 0.001), and it significantly decreased systolic (130 +/- 3 to 121 +/- 2 mmHg; P = 0.01), diastolic (69 +/- 3 to 61 +/- 2 mmHg; P = 0.04), and mean (89 +/- 2 to 81 +/- 2 mmHg; P = 0.01) arterial blood pressures at rest. Resistance training did not affect MSNA or heart rate. Arterial blood pressures and MSNA were unchanged, but heart rate increased after 8 wk of relative inactivity for subjects in the control group (61 +/- 2 to 67 +/- 3 beats/min; P = 0.01). These results indicate that whole body resistance exercise training might decrease the risk for development of cardiovascular disease by lowering arterial blood pressure but that reductions of pressure are not coupled to resistance exercise-induced decreases of sympathetic tone.

Carter, Jason R.; Ray, Chester A.; Downs, Emily M.; Cooke, William H.

2003-01-01

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Diurnal variation in blood pressure and arterial stiffness in chronic kidney disease: the role of endothelin-1.  

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Hypertension and arterial stiffness are important independent cardiovascular risk factors in chronic kidney disease (CKD) to which endothelin-1 (ET-1) contributes. Loss of nocturnal blood pressure (BP) dipping is associated with CKD progression, but there are no data on 24-hour arterial stiffness variation. We examined the 24-hour variation of BP, arterial stiffness, and the ET system in healthy volunteers and patients with CKD and the effects on these of ET receptor type A receptor antagonism (sitaxentan). There were nocturnal dips in systolic BP and diastolic BP and pulse wave velocity, our measure of arterial stiffness, in 15 controls (systolic BP, ?3.2±4.8%, Pnifedipine did not affect nocturnal dips in systolic BP or diastolic BP between baseline and week 6, whereas dipping was increased after 6-week sitaxentan treatment (baseline versus week 6, systolic BP: ?7.0±6.2 versus ?11.0±7.8 mm Hg, P<0.05; diastolic BP: ?6.0±3.6 versus ?8.3±5.1 mm Hg, P<0.05). There was no nocturnal dip in pulse pressure at baseline in the 3 phases of the study, whereas sitaxentan was linked to the development of a nocturnal dip in pulse pressure. In CKD, activation of the ET system seems to contribute not only to raised BP but also the loss of BP dipping. The clinical significance of these findings should be explored in future clinical trials. PMID:24890823

Dhaun, Neeraj; Moorhouse, Rebecca; MacIntyre, Iain M; Melville, Vanessa; Oosthuyzen, Wilna; Kimmitt, Robert A; Brown, Kayleigh E; Kennedy, Ewan D; Goddard, Jane; Webb, David J

2014-08-01

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New Cardiovascular Indices Based on a Nonlinear Spectral Analysis of Arterial Blood Pressure Waveforms  

CERN Document Server

A new method for analyzing arterial blood pressure is presented in this report. The technique is based on the scattering transform and consists in solving the spectral problem associated to a one-dimensional Schr\\"odinger operator with a potential depending linearly upon the pressure. This potential is then expressed with the discrete spectrum which includes negative eigenvalues and corresponds to the interacting components of an N-soliton. The approach is similar to a nonlinear Fourier transform where the solitons play the role of sine and cosine components. The method provides new cardiovascular indices that seem to contain relevant physiological information. We first show how to use this approach to decompose the arterial blood pressure pulse into elementary waves and to reconstruct it or to separate its systolic and diastolic phases. Then we analyse the parameters computed from this technique in two physiological conditions, the head-up 60 degrees tilt test and the isometric handgrip test, widely used for...

Laleg, Taous-Meriem; Papelier, Yves; Crépeau, Emmanuelle; Sorine, Michel

2007-01-01

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THE EFFECT OF YOGA THERAPY ON SELECTED SYSTOLIC PRESSURE AND DIASTOLIC PRESSURE VARIABLES ON STAGE ONE HYPER TENSION PATIENTS AMONG MEN  

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Full Text Available The purpose of the study is to find out the Effect of yoga therapy on selected Systolic Pressure and Diastolic pressure variables on stage one hyper tension Patients among men. Forty male subjects were selected randomly only hyper tension Patients among men at Indira Gandhi Medical College & Research Institute Hospital in Pondicherry. The subject’s age ranged from 40 to 45 years of respectively. The selected subjects were divided into two equal groups of 20 subjects each. Experimental group (Group I Yoga therapy and Control group (Group II. Pre-test was conducted for the two groups on selected Systolic Pressure and Diastolic pressure variables. The experimental group underwent Yoga therapy practices for 6 weeks, per week for the duration of the training was given for 5 days per week 45 minutes every day. The control group did not undergo any training program. After 6 weeks of training period the post test was conducted for all the two groups. The data was analyzed by applying Analysis of Variance (ANOVA Technique to find out the effect of yoga therapy on selected physiological variables on stage one hyper tension patients among men. Then, the obtained ‘f’ratio is tested at 0.05 level of significant

R. Sendhil

2014-11-01

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Impact of Two Types of Sodium and Ultra Filtration Profiles on Systolic and Diastolic Blood Pressure in patients during Hemodialysis  

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Full Text Available Background & Aim: Intradialytic hypotension is the most frequent complication in patients receiving haemodialysis (HD. This complication not only contributes to the illness of the patients, but also decreases the efficacy of the HD. So, hypotension prevention is a major challenge for medical team, especially for nurses. One of the preventive methods that have recently been presented is the use of sodium profile and ultra filtration (UF profile. The aim of this study was to compare the effects of linear sodium + UF profile (type1 with stepwise sodium + UF profile (type3 on systolic and diastolic blood pressure in HD patients. Methods & Materials: In this crossover design study, 26 HD patients from two dialysis centers at Esfahan University underwent three kinds of treatment: (1 control, constant dialysate sodium concentration of 138 mmol/L with constant UF; (2 linear sodium profile + UF profile (type1, a linearly decreasing dialysate sodium concentration (146-138mmol/L in combination with a linearly decreasing UF rate; and (3 stepwise sodium profile + UF profile (type2, a stepwise decreasing dialysate sodium concentration (146-138 mmol/L in combination with a stepwise decreasing UF rate. Each treatment was applied in three dialysis sessions. Data were analyzed using repeated measure ANOVA test in the SPSS. Results: Twenty six patients participated in the study. A total of 234 dialysis sessions were analyzed. There were no significant differences in the systolic blood pressure between three groups during predialysis and first and the second hours (P>0.05. The mean of systolic blood pressures were higher in the third hour and postdialysis during two types of profiles (1&3 compared with the routine care group (P<0.05. The mean of diastolic blood pressure was also higher in postdialysis during two types of profiles (1&3 compared with the routine group (P<0.05. There was no significant difference between the profiles 1and 3 (P>0.05. Conclusion: In conclusion, sodium profile + UF profile is a simple and cost-effective method that modulate the dialysate sodium and ultra filtration rate and preserve the homodynamic status and blood pressure of patients during dialysis. Therefore, using sodium profile + UF profile (type1 & type3 is recommended in order to prevent hypotension and reduce nursing work during hemodialysis process.  

M Ghafourifard

2010-08-01

77

Probing genetic overlap in the regulation of systolic and diastolic blood pressure in Danish and Chinese twins.  

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Although the phenotypic correlation between systolic blood pressure (SBP) and diastolic blood pressure (DBP) is well known, the genetic basis for the correlation has rarely been investigated. The aim of this paper is to examine the genetic overlap between SBP and DBP by fitting bivariate models to Danish and Chinese twins and comparing ethnic differences between the two samples. Our estimates revealed a high proportion of additive genetic components shared by both SBP and DBP in Danish (0.71, 95% confidence interval (CI): 0.65-0.75) and Chinese (0.62, 95% CI: 0.50-0.71) twins with no statistically significant ethnic differences. The estimated genetic component in phenotypic correlation could serve to guide molecular genetic studies searching for genetic variants that affect both SBP and DBP. The bivariate model also estimated genetic and environmental contributions to SBP and DBP separately, with an overall pattern of higher genetic regulation or heritability in Danish (0.72, 95% CI: 0.67-0.76 for SBP; 0.70, 95% CI: 0.65-0.75 for DBP) than in Chinese (0.54, 95% CI: 0.44-0.63 for SBP; 0.57, 95% CI: 0.47-0.65 for DBP) twins and a higher contribution from unique environmental factors in Chinese compared with Danish twins. The estimated contribution from unique environmental factors suggests that promoting healthy lifestyles may provide an efficient way of controlling high blood pressure, particularly in the Chinese population. PMID:24830538

Li, Shuxia; Pang, Zengchang; Zhang, Dongfeng; Duan, Haiping; von Bornemann Hjelmborg, Jacob; Tan, Qihua; Kruse, Torben Arvid; Kyvik, Kirsten Ohm

2014-10-01

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Avaliação das medidas de pressão arterial comparando o método tradicional e o padrão-ouro / Evaluation of arterial pressure measurements comparing traditional and gold standard methods  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese OBJETIVO: Avaliar as medidas de pressão arterial comparando o método tradicional e o padrão-ouro em um serviço público de pronto atendimento. MÉTODOS: Estudo transversal no qual as medidas das pressões arteriais sistólica, diastólica, média e de pulso aferidas pelos profissionais da enfermagem pelo [...] método tradicional foram comparadas com aquelas realizadas de acordo com o padrão-ouro. RESULTADOS: Foram incluídos 229 clientes, 69% do sexo feminino e a média de idade foi de 50 anos. A comparação entre os dois métodos mostrou que o valor médio das pressões sistólica, diastólica, média e de pulso foi maior utilizando-se a técnica padrão-ouro. CONCLUSÃO: Houve divergências entre as medidas realizadas pela técnica recomendada e pela classificação de risco. Abstract in english OBJECTIVE: Evaluating arterial pressure measurements comparing the traditional and the gold standard methods in an emergency public service. METHODS: Cross-sectional study, in which arterial systolic, diastolic, mean and pulse pressure measurements obtained by nursing professionals by means of the t [...] raditional method were compared with those obtained using the gold standard technique. RESULTS: Study participants were 229 patients, 69% were women and the mean age was 50 years. The comparison between the two methods showed that the mean value of the arterial systolic, diastolic, mean and pulse pressures was higher using the gold standard technique. CONCLUSION: Divergences were found between the measurements obtained using the recommended technique and the risk classification.

Luciano Elias E, Silva; Ruth Ester Assayag, Batista; Cássia Regina Vancini, Campanharo; Ricardo Baladi Rufino, Pereira; Gilmar Fernandes do, Prado.

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Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study  

Science.gov (United States)

The prevalence of hypertension in African Americans (AAs) is higher than in other US groups; yet, few have performed genome-wide association studies (GWASs) in AA. Among people of European descent, GWASs have identified genetic variants at 13 loci that are associated with blood pressure. It is unknown if these variants confer susceptibility in people of African ancestry. Here, we examined genome-wide and candidate gene associations with systolic blood pressure (SBP) and diastolic blood pressure (DBP) using the Candidate Gene Association Resource (CARe) consortium consisting of 8591 AAs. Genotypes included genome-wide single-nucleotide polymorphism (SNP) data utilizing the Affymetrix 6.0 array with imputation to 2.5 million HapMap SNPs and candidate gene SNP data utilizing a 50K cardiovascular gene-centric array (ITMAT-Broad-CARe [IBC] array). For Affymetrix data, the strongest signal for DBP was rs10474346 (P= 3.6 × 10?8) located near GPR98 and ARRDC3. For SBP, the strongest signal was rs2258119 in C21orf91 (P= 4.7 × 10?8). The top IBC association for SBP was rs2012318 (P= 6.4 × 10?6) near SLC25A42 and for DBP was rs2523586 (P= 1.3 × 10?6) near HLA-B. None of the top variants replicated in additional AA (n = 11 882) or European-American (n = 69 899) cohorts. We replicated previously reported European-American blood pressure SNPs in our AA samples (SH2B3, P= 0.009; TBX3-TBX5, P= 0.03; and CSK-ULK3, P= 0.0004). These genetic loci represent the best evidence of genetic influences on SBP and DBP in AAs to date. More broadly, this work supports that notion that blood pressure among AAs is a trait with genetic underpinnings but also with significant complexity. PMID:21378095

Fox, Ervin R.; Young, J. Hunter; Li, Yali; Dreisbach, Albert W.; Keating, Brendan J.; Musani, Solomon K.; Liu, Kiang; Morrison, Alanna C.; Ganesh, Santhi; Kutlar, Abdullah; Ramachandran, Vasan S.; Polak, Josef F.; Fabsitz, Richard R.; Dries, Daniel L.; Farlow, Deborah N.; Redline, Susan; Adeyemo, Adebowale; Hirschorn, Joel N.; Sun, Yan V.; Wyatt, Sharon B.; Penman, Alan D.; Palmas, Walter; Rotter, Jerome I.; Townsend, Raymond R.; Doumatey, Ayo P.; Tayo, Bamidele O.; Mosley, Thomas H.; Lyon, Helen N.; Kang, Sun J.; Rotimi, Charles N.; Cooper, Richard S.; Franceschini, Nora; Curb, J. David; Martin, Lisa W.; Eaton, Charles B.; Kardia, Sharon L.R.; Taylor, Herman A.; Caulfield, Mark J.; Ehret, Georg B.; Johnson, Toby; Chakravarti, Aravinda; Zhu, Xiaofeng; Levy, Daniel; Munroe, Patricia B.; Rice, Kenneth M.; Bochud, Murielle; Johnson, Andrew D.; Chasman, Daniel I.; Smith, Albert V.; Tobin, Martin D.; Verwoert, Germaine C.; Hwang, Shih-Jen; Pihur, Vasyl; Vollenweider, Peter; O'Reilly, Paul F.; Amin, Najaf; Bragg-Gresham, Jennifer L.; Teumer, Alexander; Glazer, Nicole L.; Launer, Lenore; Zhao, Jing Hua; Aulchenko, Yurii; Heath, Simon; Sober, Siim; Parsa, Afshin; Luan, Jian'an; Arora, Pankaj; Dehghan, Abbas; Zhang, Feng; Lucas, Gavin; Hicks, Andrew A.; Jackson, Anne U.; Peden, John F.; Tanaka, Toshiko; Wild, Sarah H.; Rudan, Igor; Igl, Wilmar; Milaneschi, Yuri; Parker, Alex N.; Fava, Cristiano; Chambers, John C.; Kumari, Meena; JinGo, Min; van der Harst, Pim; Kao, Wen Hong Linda; Sjogren, Marketa; Vinay, D.G.; Alexander, Myriam; Tabara, Yasuharu; Shaw-Hawkins, Sue; Whincup, Peter H.; Liu, Yongmei; Shi, Gang; Kuusisto, Johanna; Seielstad, Mark; Sim, Xueling; Nguyen, Khanh-Dung Hoang; Lehtimaki, Terho; Matullo, Giuseppe; Wu, Ying; Gaunt, Tom R.; Charlotte Onland-Moret, N.; Cooper, Matthew N.; Platou, Carl G.P.; Org, Elin; Hardy, Rebecca; Dahgam, Santosh; Palmen, Jutta; Vitart, Veronique; Braund, Peter S.; Kuznetsova, Tatiana; Uiterwaal, Cuno S.P.M.; Campbell, Harry; Ludwig, Barbara; Tomaszewski, Maciej; Tzoulaki, Ioanna; Palmer, Nicholette D.; Aspelund, Thor; Garcia, Melissa; Chang, Yen-Pei C.; O'Connell, Jeffrey R.; Steinle, Nanette I.; Grobbee, Diederick E.; Arking, Dan E.; Hernandez, Dena; Najjar, Samer; McArdle, Wendy L.; Hadley, David; Brown, Morris J.; Connell, John M.; Hingorani, Aroon D.; Day, Ian N.M.; Lawlor, Debbie A.; Beilby, John P.; Lawrence, Robert W.; Clarke, Robert; Collins, Rory; Hopewell, Jemma C.; Ongen, Halit; Bis, Joshua C.; Kahonen, Mika; Viikari, Jorma; Adair, Linda S.; Lee, Nanette R.; Chen, Ming-Huei; Olden, Matthias; Pattaro, Cristian; Hoffman Bolton, Judith A.; Kottgen, Anna; Bergmann, Sven; Mooser, Vincent; Chaturvedi, Nish; Frayling, Timothy M.; Islam, Muhammad; Jafar, Tazeen H.; Erdmann, Jeanette; Kulkarni, Smita R.; Bornstein, Stefan R.; Grassler, Jurgen; Groop, Leif; Voight, Benjamin F.; Kettunen, Johannes; Howard, Philip; Taylor, Andrew; Guarrera, Simonetta; Ricceri, Fulvio; Emilsson, Valur; Plump, Andrew; Barroso, Ines; Khaw, Kay-Tee; Weder, Alan B.; Hunt, Steven C.; Bergman, Richard N.; Collins, Francis S.; Bonnycastle, Lori L.; Scott, Laura J.; Stringham, Heather M.; Peltonen, Leena; Perola, Markus; Vartiainen, Erkki; Brand, Stefan-Martin; Staessen, Jan A.; Wang, Thomas J.; Burton, Paul R.; SolerArtigas, Maria; Dong, Yanbin; Snieder, Harold; Wang, Xiaoling; Zhu, Haidong; Lohman, Kurt K.; Rudock, Megan E.; Heckbert, Susan R.; Smith, Nicholas L.; Wiggins, Kerri L.; Shriner, Daniel; Veldre, Gudrun; Viigimaa, Margus; Kinra, Sanjay; Prabhakaran, Dorairajan; Tripathy, Vikal; Langefeld, Carl D.; Rosengren, Annika; Thelle, Dag S.; MariaCorsi, Anna; Singleton, Andrew; Forrester, Terrence; Hilton, Gina; McKenzie, Colin A.; Salako, Tunde; Iwai, Naoharu; Kita, Yoshikuni; Ogihara, Toshio; Ohkubo, Takayoshi; Okamura, Tomonori; Ueshima, Hirotsugu; Umemura, Satoshi; Eyheramendy, Susana; Meitinger, Thomas; Wichmann, H.-Erich; Cho, Yoon Shin; Kim, Hyung-Lae; Lee, Jong-Young; Scott, James; Sehmi, Joban S.; Zhang, Weihua; Hedblad, Bo; Nilsson, Peter; Smith, George Davey; Wong, Andrew; Narisu, Narisu; Stancakova, Alena; Raffel, Leslie J.; Yao, Jie; Kathiresan, Sekar; O'Donnell, Chris; Schwartz, Steven M.; Arfan Ikram, M.; Longstreth, Will T.; Seshadri, Sudha; Shrine, Nick R.G.; Wain, Louise V.; Morken, Mario A.; Swift, Amy J.; Laitinen, Jaana; Prokopenko, Inga; Zitting, Paavo; Cooper, Jackie A.; Humphries, Steve E.; Danesh, John; Rasheed, Asif; Goel, Anuj; Hamsten, Anders; Watkins, Hugh; Bakker, Stephan J.L.; van Gilst, Wiek H.; Janipalli, Charles S.; Radha Mani, K.; Yajnik, Chittaranjan S.; Hofman, Albert

2011-01-01

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The Relation Between Aortic Pulse Pressure and Coronary Artery Disease  

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Full Text Available Objective: Pulse pressure (PP is a significant marker of cardiovascular morbidity.We investigated the relation between aortic PP and the presence and extent of coronary artery disease (CAD in patients undergoing diagnostic coronary angiography (CAG.Patients and Method: The study group consisted of 550 patients (363 men, 187 women.We evaluated patients in two different groups, PP < 60 mmHg and ? 60 mmHg.Results: In univariate analysis gender and presence of hyperlipidemia showed no statistically significant differences between both groups. However, the ratio of patients having diabetes mellitus, hypertension or smoking were significantly higher in ? 60 mmHg PP group. The mean age was 55.2 ±11.9 in < 60 mmHg PP group and 61.3±9.3 in the other group (p<0.01. Although systolic blood pressure level was higher in ? 60 mmHg PP group (160.4±21.1 vs. 126.4±13.5, p< 0.001, diastolic blood pressure level showed no significant differences between both groups (78.3±13.5 vs. 80.3±10.2, p= 0.32. In the <60 mmHg PP group, the ratio of normal CAG was significantly higher, and also, the critically CAD rate was lower than the other group. In multivariate analysis, smoking [odds ratios (OR 2.344, 95% confidence intervals (CI, 1.416-3.879], male gender (OR 5.858, 95% CI, 3.425-10.019 and PP ?60 mmHg (OR 25.788, 95% CI, 14.001-47.498 were evaluated as an independent indicators of CAD.Conclusions: In our study, we demonstrate that, aortic PP ?60 mmHg is related to the risk of critically CAD as an independent factor.

Ali Metin Esen

2011-08-01

 
 
 
 
81

Determining the Arterial Blood Pressure of People Living in Yesilyurt Local Healthcare Office  

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Full Text Available AIM: Whereas the prevalance of arterial blood pressure which was a chronical health problem was 20%-25% among 30 year-old people, them showing an increase in aging, the percentage went as high as 50% in 60?s and later ages. What was that worrisome was that despite the high prevalance, only half of these received treathment. This is study was descriptively and cross-sectionally planned to determine whether the people asking their tensions to be measured in and around the Yesilyurt local healthcare office region. METHODS: The environment of the research consisted of 1400 people over 35 age and registered Yesilyurt Local healthcare Office and the whole of the environment were included in this sample. The study was conducted over 340 voluntaries. The data was collected by a questionnaire of 14 questions containing socio-demografic features and by measuring the arterial blood pressure, height and weight of the individuals. In the evaluation of the data, chi-square test was used and the level of significantly was accepted as 0.05. RESULTS: In this study, the rate of high sistolic blood pressure was found to be 21.47% and the rate of high diastolic blood pressure to be 8.23%. It was determined that age and body mass index varrieties were effective on sistolic hipertension. It was also found that in their behaviors of the use of hypertensive medicine, of regular arterial pressure controls and of having the hypertesion diagnosis significant differnces varied statistically on both sistolic and diastolic blood pressure people having. CONCLUSION: In order to improve the health, informative information abouth hypertension was provided for the participants for too days consisting of 4 sessions. [TAF Prev Med Bull 2009; 8(1.000: 53-58

Feyza Dereli

2009-02-01

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Influence of the elevation of the left ventricular diastolic pressure on the values of the first temporal derivative of the ventricular pressure (dP/dt  

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Full Text Available PURPOSE: To assess the effects of the elevation of the left ventricular end-diastolic pressure (LVEDP on the value of the 1st temporal derivative of the ventricular pressure (dP/dt. METHODS: Nineteen anesthetized dogs were studied. The dogs were mechanically ventilated and underwent thoracotomy with parasympathetic nervous system block. The LVEDP was controlled with the use of a perfusion circuit connected to the left atrium and adjusted to the height of a reservoir. The elevation of the LVEDP was achieved by a sudden increase in the height of a reservoir filled with blood. Continuous recordings of the electrocardiogram, the aortic and ventricular pressures and the dP/dt were performed. RESULTS: Elevation of the LVEDP did not result in any variation of the heart rate (167±16.0bpm, before the procedure; 167±15.5bpm, after the procedure. All the other variables assessed, including systolic blood pressure (128±18.3mmHg and 150±21.5mmHg, diastolic blood pressure (98±16.9mmHg and 115±19.8mmHg, LVEDP (5.5±2.49 and 9.3±3.60mmHg, and dP/dt (4,855 ± 1,082 mmHg/s and 5,149±1,242mmHg/s showed significant increases following the expansion of the ventricular cavity. Although the elevation of the dP/dt was statistically significant, 6 dogs curiously showed a decrease in the values of dP/dt. CONCLUSION: Sudden elevation of the LVEDP resulted in increased values of dP/dt; however, in some dogs, this response was not uniform.

Okoshi Katashi

1999-01-01

83

Changes in the retrobulbar arterial circulation after decrease of the elevated intraocular pressure in men and women with primary open angle glaucoma  

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Full Text Available Introduction. An altered perfusion of the optic nerve head has been proposed as a pathogenic factor of glaucoma. Objective. The aim of this study was to evaluate the changes of the hemodynamic parameters in the retrobulbar arterial circulation after decrease of the elevated intraocular pressure (IOP in women and men with primary open angle glaucoma. Methods. The study included 60 patients (33 males and 27 females older than 50 years, with diagnosed and treated primary open angle glaucoma (77 eyes of 39 patients had increased IOP, >25 mm Hg. They were examined at the Clinic of Eye Diseases (complete ophthalmologic exam and Clinic of Neurology, Clinical Center of Serbia, Belgrade, from December 2009 to December 2010. Imaging of hemodynamic parameters of three retrobulbar arterial vessels: ophthalmic, central retinal and posterior ciliary arteries with color Doppler was performed. Results. Among women, hemodynamic arterial parameter of the peak-systolic velocity was increased in the central retinal artery and decreased in the ophthalmic artery and posterior ciliary arteries; end- diastolic velocity was increased in all three retrobulbar vascular levels; Pourcelot resistivity index was increased, but pulsatility index was decreased in all three vessels. Among men, peak-systolic velocity, end-diastolic velocity and pulsatility index were decreased in all three vessels; resistivity index was increased in the ophthalmic artery, but decreased in the central retinal artery and posterior ciliary arteries. There was a significant change of the ophthalmic artery pulsatility index in women, and the end-diastolic velocity of the ophthalmic artery in men. Conclusion. There was a difference of the retrobulbar arterial circulation between women and men with primary open angle glaucoma after decrease of the elevated intraocular pressure. The role of vascular factors in the supply of the optic disc neuroretinal rim is important.

Marjanovi? Ivan

2013-01-01

84

Valores de presión arterial en escolares sanos de una escuela primaria del municipio Cerro Arterial pressure values in healthy students from a primary school of Cerro municipality  

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Full Text Available INTRODUCCIÓN: la hipertensión constituye un notable problema de salud en el ámbito mundial que determina una importante causa de morbilidad, en la que están involucrados factores genéticos y ambientales. La presión arterial en la infancia aumenta progresivamente a lo largo de los años, y es una importante variable a considerar. OBJETIVO: caracterizar el comportamiento de algunas variables cardiovasculares y nutricionales en escolares supuestamente sanos. MÉTODOS: se realizó un estudio de tipo descriptivo de cohorte transversal, en el que fueron estudiados escolares supuestamente sanos de una escuela primaria del municipio Cerro, en Ciudad de La Habana, en el período comprendido desde el 1ro. de diciembre de 2006 al 28 de febrero de 2007. El universo estuvo constituido por 358 niños de ambos sexos entre 5 y 11 años de edad. Las variables estudiadas fueron: presión arterial sistólica, presión arterial diastólica, presión arterial media, frecuencia cardiaca, peso, talla e índice de masa corporal. RESULTADOS: los resultados muestran cifras de presión arterial sistólica entre 77 y 104 mmHg, valores de presión arterial diastólica entre 43 a 64 mmHg, mientras que los valores de presión arterial media oscilan en un intervalo de 57 a 72 mmHg. La frecuencia cardiaca fue mayor en escolares de menor edad con respecto a los de mayor edad. El peso, la talla y el índice de masa corporal se incrementan con la edad. CONCLUSIONES: se concluye que los valores de presión arterial sistólica, diastólica y media en escolares de ambos sexos se incrementan con la edad, no así los de frecuencia cardiaca, cuya tendencia es a disminuir a medida que la edad aumenta. Los valores que corresponden al índice de masa corporal se elevan con la edad.INTRODUCTION: hypertension is a marked health problem at world scale determining significant causes of morbidity, in which are involved genetic and environmental factors. Infantile arterial pressure increases progressively during years, and it is a significant variable to be considered. AIM: to characterize behavior of some cardiovascular and nutritional variables in supposedly healthy students. METHODS: authors made a cross-sectional descriptive study in supposedly health students from a primary school of Cerro municipality in Havana City from December 1st 2006 to February 28, 2007. Sample included 358 children of both sexes aged between 5 and 11. Study variable were: systolic high blood pressure, diastolic arterial pressure, mean arterial pressure, cardiac frequency, weight, height and body mass index (BMI. RESULTS: results show figures of systolic arterial pressure between 77 and 104 mmHg, diastolic arterial pressure between 43 and 64 mmHg, whereas mean arterial pressure oscillate in a interval of 57-72 mmHg. Cardiac frequency was greater in younger ones regarding those oldest. Weight, height and MBI increase with age. CONCLUSIONS: we conclude that systolic, diastolic and mean arterial pressure in students of both sexes increase with age, but not cardiac frequency, whose trend is to decrease insofar as age increases. Values corresponding to BMI increase with age.

Roberto Francisco Corredera Guerra

2009-03-01

85

Porcine radial artery decellularization by high hydrostatic pressure.  

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Many types of decellularized tissues have been studied and some have been commercially used in clinics. In this study, small-diameter vascular grafts were made using HHP to decellularize porcine radial arteries. One decellularization method, high hydrostatic pressure (HHP), has been used to prepare the decellularized porcine tissues. Low-temperature treatment was effective in preserving collagen and collagen structures in decellularized porcine carotid arteries. The collagen and elastin structures and mechanical properties of HHP-decellularized radial arteries were similar to those of untreated radial arteries. Xenogeneic transplantation (into rats) was performed using HHP-decellularized radial arteries and an untreated porcine radial artery. Two weeks after transplantation into rat carotid arteries, the HHP-decellularized radial arteries were patent and without thrombosis. In addition, the luminal surface of each decellularized artery was covered by recipient endothelial cells and the arterial medium was fully infiltrated with recipient cells. Copyright © 2012 John Wiley & Sons, Ltd. PMID:23233238

Negishi, Jun; Funamoto, Seiichi; Kimura, Tsuyoshi; Nam, Kwangoo; Higami, Tetsuya; Kishida, Akio

2012-12-12

86

Effects of mercury on the arterial blood pressure of anesthetized rats  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in english The available data suggests that hypotension caused by Hg2+ administration may be produced by a reduction of cardiac contractility or by cholinergic mechanisms. The hemodynamic effects of an intravenous injection of HgCl2 (5 mg/kg) were studied in anesthetized rats (N = 12) by monitoring left and ri [...] ght ventricular (LV and RV) systolic and diastolic pressures for 120 min. After HgCl2 administration the LV systolic pressure decreased only after 40 min (99 ± 3.3 to 85 ± 8.8 mmHg at 80 min). However, RV systolic pressure increased, initially slowly but faster after 30 min (25 ± 1.8 to 42 ± 1.6 mmHg at 80 min). Both right and left diastolic pressures increased after HgCl2 treatment, suggesting the development of diastolic ventricular dysfunction. Since HgCl2 could be increasing pulmonary vascular resistance, isolated lungs (N = 10) were perfused for 80 min with Krebs solution (continuous flow of 10 ml/min) containing or not 5 µM HgCl2. A continuous increase in pulmonary vascular resistance was observed, suggesting the direct effect of Hg2+ on the pulmonary vessels (12 ± 0.4 to 29 ± 3.2 mmHg at 30 min). To examine the interactions of Hg2+ and changes in cholinergic activity we analyzed the effects of acetylcholine (Ach) on mean arterial blood pressure (ABP) in anesthetized rats (N = 9) before and after Hg2+ treatment (5 mg/kg). Using the same amount and route used to study the hemodynamic effects we also examined the effects of Hg2+ administration on heart and plasma cholinesterase activity (N = 10). The in vivo hypotensive response to Ach (0.035 to 10.5 µg) was reduced after Hg2+ treatment. Cholinesterase activity (µM h-1 mg protein-1) increased in heart and plasma (32 and 65%, respectively) after Hg2+ treatment. In conclusion, the reduction in ABP produced by Hg2+ is not dependent on a putative increase in cholinergic activity. HgCl2 mainly affects cardiac function. The increased pulmonary vascular resistance and cardiac failure due to diastolic dysfunction of both ventricles are factors that might contribute to the reduction of cardiac output and the fall in arterial pressure.

L.V., Rossoni; S.M.C., Amaral; P.F., Vassallo; A., França; E.M., Oliveira; K.J., Varner; J.G., Mill; D.V., Vassallo.

1999-08-01

87

Effects of mercury on the arterial blood pressure of anesthetized rats  

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Full Text Available The available data suggests that hypotension caused by Hg2+ administration may be produced by a reduction of cardiac contractility or by cholinergic mechanisms. The hemodynamic effects of an intravenous injection of HgCl2 (5 mg/kg were studied in anesthetized rats (N = 12 by monitoring left and right ventricular (LV and RV systolic and diastolic pressures for 120 min. After HgCl2 administration the LV systolic pressure decreased only after 40 min (99 ± 3.3 to 85 ± 8.8 mmHg at 80 min. However, RV systolic pressure increased, initially slowly but faster after 30 min (25 ± 1.8 to 42 ± 1.6 mmHg at 80 min. Both right and left diastolic pressures increased after HgCl2 treatment, suggesting the development of diastolic ventricular dysfunction. Since HgCl2 could be increasing pulmonary vascular resistance, isolated lungs (N = 10 were perfused for 80 min with Krebs solution (continuous flow of 10 ml/min containing or not 5 µM HgCl2. A continuous increase in pulmonary vascular resistance was observed, suggesting the direct effect of Hg2+ on the pulmonary vessels (12 ± 0.4 to 29 ± 3.2 mmHg at 30 min. To examine the interactions of Hg2+ and changes in cholinergic activity we analyzed the effects of acetylcholine (Ach on mean arterial blood pressure (ABP in anesthetized rats (N = 9 before and after Hg2+ treatment (5 mg/kg. Using the same amount and route used to study the hemodynamic effects we also examined the effects of Hg2+ administration on heart and plasma cholinesterase activity (N = 10. The in vivo hypotensive response to Ach (0.035 to 10.5 µg was reduced after Hg2+ treatment. Cholinesterase activity (µM h-1 mg protein-1 increased in heart and plasma (32 and 65%, respectively after Hg2+ treatment. In conclusion, the reduction in ABP produced by Hg2+ is not dependent on a putative increase in cholinergic activity. HgCl2 mainly affects cardiac function. The increased pulmonary vascular resistance and cardiac failure due to diastolic dysfunction of both ventricles are factors that might contribute to the reduction of cardiac output and the fall in arterial pressure.

Rossoni L.V.

1999-01-01

88

Effects of mercury on the arterial blood pressure of anesthetized rats  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in english The available data suggests that hypotension caused by Hg2+ administration may be produced by a reduction of cardiac contractility or by cholinergic mechanisms. The hemodynamic effects of an intravenous injection of HgCl2 (5 mg/kg) were studied in anesthetized rats (N = 12) by monitoring left and ri [...] ght ventricular (LV and RV) systolic and diastolic pressures for 120 min. After HgCl2 administration the LV systolic pressure decreased only after 40 min (99 ± 3.3 to 85 ± 8.8 mmHg at 80 min). However, RV systolic pressure increased, initially slowly but faster after 30 min (25 ± 1.8 to 42 ± 1.6 mmHg at 80 min). Both right and left diastolic pressures increased after HgCl2 treatment, suggesting the development of diastolic ventricular dysfunction. Since HgCl2 could be increasing pulmonary vascular resistance, isolated lungs (N = 10) were perfused for 80 min with Krebs solution (continuous flow of 10 ml/min) containing or not 5 µM HgCl2. A continuous increase in pulmonary vascular resistance was observed, suggesting the direct effect of Hg2+ on the pulmonary vessels (12 ± 0.4 to 29 ± 3.2 mmHg at 30 min). To examine the interactions of Hg2+ and changes in cholinergic activity we analyzed the effects of acetylcholine (Ach) on mean arterial blood pressure (ABP) in anesthetized rats (N = 9) before and after Hg2+ treatment (5 mg/kg). Using the same amount and route used to study the hemodynamic effects we also examined the effects of Hg2+ administration on heart and plasma cholinesterase activity (N = 10). The in vivo hypotensive response to Ach (0.035 to 10.5 µg) was reduced after Hg2+ treatment. Cholinesterase activity (µM h-1 mg protein-1) increased in heart and plasma (32 and 65%, respectively) after Hg2+ treatment. In conclusion, the reduction in ABP produced by Hg2+ is not dependent on a putative increase in cholinergic activity. HgCl2 mainly affects cardiac function. The increased pulmonary vascular resistance and cardiac failure due to diastolic dysfunction of both ventricles are factors that might contribute to the reduction of cardiac output and the fall in arterial pressure.

L.V., Rossoni; S.M.C., Amaral; P.F., Vassallo; A., França; E.M., Oliveira; K.J., Varner; J.G., Mill; D.V., Vassallo.

89

ORANGE JUICE AND BLOOD PRESSURE  

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Blood pressure is the force of blood against artery walls. It is measured in millimeters of mercury (mm Hg) and recorded as two numbers: systolic pressure (as the heart contracts) over diastolic pressure (as the heart relaxes between beats). High blood pressure (hypertension) is defined as chronically elevated high blood pressure, with systolic blood pressure (SBP) of 140 mm Hg or greater, and diastolic blood pressure (DBP) of 90 mm Hg or greater. High blood pressure ...

Valim, M. F.; Barros, S.

2009-01-01

90

Downstream Hepatic Arterial Blood Pressure Changes Caused by Deployment of the Surefire AntiReflux Expandable Tip  

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Purpose: The purpose of this work was to evaluate blood pressure changes caused by deployment of the Surefire antireflux expandable tip. The pressure measurements are relevant because they imply changes in hepatoenteric arterial blood flow within this liver compartment during hepatic artery delivery of cytotoxic agents. Methods: After positioning the Surefire antireflux system in the targeted hepatic artery, blood pressure was obtained initially with the tip collapsed (or through a femoral artery sheath), then again after the tip was expanded before chemoembolization or yttrium 90 ({sup 90}Y) radioembolization. Results: Eighteen patients with liver malignancy underwent 29 procedures in 29 hepatic arteries (3 common hepatic, 22 lobar, 4 segmental). Systolic, diastolic, and mean blood pressure were all decreased by a mean of 29 mm Hg (p = 0.000004), 14 mm Hg (p = 0.0000004), and 22 mm Hg (p = 0.00000001), respectively. Conclusion: When the Surefire expandable tip is deployed to prevent retrograde reflux of agents, it also results in a significant decrease in blood pressure in the antegrade distribution, potentially resulting in hepatopedal blood flow in vessels that are difficult to embolize, such as the supraduodenal arteries.

Rose, Steven C., E-mail: scrose@ucsd.edu; Kikolski, Steven G. [University of California, San Diego Health Sciences, Department of Radiology 8756, UCSD Medical Center (United States); Chomas, James E. [Surefire Medical, Inc. (United States)

2013-10-15

91

Downstream Hepatic Arterial Blood Pressure Changes Caused by Deployment of the Surefire AntiReflux Expandable Tip  

International Nuclear Information System (INIS)

Purpose: The purpose of this work was to evaluate blood pressure changes caused by deployment of the Surefire antireflux expandable tip. The pressure measurements are relevant because they imply changes in hepatoenteric arterial blood flow within this liver compartment during hepatic artery delivery of cytotoxic agents. Methods: After positioning the Surefire antireflux system in the targeted hepatic artery, blood pressure was obtained initially with the tip collapsed (or through a femoral artery sheath), then again after the tip was expanded before chemoembolization or yttrium 90 (90Y) radioembolization. Results: Eighteen patients with liver malignancy underwent 29 procedures in 29 hepatic arteries (3 common hepatic, 22 lobar, 4 segmental). Systolic, diastolic, and mean blood pressure were all decreased by a mean of 29 mm Hg (p = 0.000004), 14 mm Hg (p = 0.0000004), and 22 mm Hg (p = 0.00000001), respectively. Conclusion: When the Surefire expandable tip is deployed to prevent retrograde reflux of agents, it also results in a significant decrease in blood pressure in the antegrade distribution, potentially resulting in hepatopedal blood flow in vessels that are difficult to embolize, such as the supraduodenal arteries

92

Right ventricular diastolic abnormalities in systemic sclerosis. Relation to left ventricular involvement and pulmonary hypertension  

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OBJECTIVES—To investigate right ventricular diastolic function in systemic sclerosis (SSc) and its relation to clinical features of the disease.?METHODS—Seventy seven unselected SSc patients and 33 healthy subjects were submitted to echocardiography and echo Doppler study to assess left and right systolic as well diastolic function and to estimate maximal arterial systolic pulmonary pressure (PAP). In addition, the patients were investigated to define the SSc subset and the extent of s...

Giunta, A.; Tirri, E.; Maione, S.; Cangianiello, S.; Mele, A.; Luca, A.; Valentini, G.

2000-01-01

93

Artificial arterial blood pressure artifact models and an evaluation of a robust blood pressure and heart rate estimator  

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Full Text Available Abstract Background Within the intensive care unit (ICU, arterial blood pressure (ABP is typically recorded at different (and sometimes uneven sampling frequencies, and from different sensors, and is often corrupted by different artifacts and noise which are often non-Gaussian, nonlinear and nonstationary. Extracting robust parameters from such signals, and providing confidences in the estimates is therefore difficult and requires an adaptive filtering approach which accounts for artifact types. Methods Using a large ICU database, and over 6000 hours of simultaneously acquired electrocardiogram (ECG and ABP waveforms sampled at 125 Hz from a 437 patient subset, we documented six general types of ABP artifact. We describe a new ABP signal quality index (SQI, based upon the combination of two previously reported signal quality measures weighted together. One index measures morphological normality, and the other degradation due to noise. After extracting a 6084-hour subset of clean data using our SQI, we evaluated a new robust tracking algorithm for estimating blood pressure and heart rate (HR based upon a Kalman Filter (KF with an update sequence modified by the KF innovation sequence and the value of the SQI. In order to do this, we have created six novel models of different categories of artifacts that we have identified in our ABP waveform data. These artifact models were then injected into clean ABP waveforms in a controlled manner. Clinical blood pressure (systolic, mean and diastolic estimates were then made from the ABP waveforms for both clean and corrupted data. The mean absolute error for systolic, mean and diastolic blood pressure was then calculated for different levels of artifact pollution to provide estimates of expected errors given a single value of the SQI. Results Our artifact models demonstrate that artifact types have differing effects on systolic, diastolic and mean ABP estimates. We show that, for most artifact types, diastolic ABP estimates are less noise-sensitive than mean ABP estimates, which in turn are more robust than systolic ABP estimates. We also show that our SQI can provide error bounds for both HR and ABP estimates. Conclusion The KF/SQI-fusion method described in this article was shown to provide an accurate estimate of blood pressure and HR derived from the ABP waveform even in the presence of high levels of persistent noise and artifact, and during extreme bradycardia and tachycardia. Differences in error between artifact types, measurement sensors and the quality of the source signal can be factored into physiological estimation using an unbiased adaptive filter, signal innovation and signal quality measures.

Mark Roger G

2009-07-01

94

Doppler Tissue Imaging: A Non-Invasive Technique for Estimation of Left Ventricular End Diastolic Pressure in Severe Mitral Regurgitation  

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Full Text Available Background: Conventional Doppler measurements, including mitral inflow and pulmonary venous flow, are used to estimate left ventricular end diastolic pressure (LVEDP. However, these parameters have limitations in predicting LVEDP among patients with mitral regurgitation. This study sought to establish whether the correlation between measurements derived from tissue Doppler echocardiography and LVEDP remains valid in the setting of severe mitral regurgitation.Methods: Thirty patients (mean age: 57.37 ± 13.29 years with severe mitral regurgitation and a mean left ventricular ejection fraction (EF of 46.0 ± 14.95 were enrolled; 16 (53.4% patients were defined to have EF < 50% and 14 (46.6% patients had EF ? 50%. Doppler signals from the mitral inflow, pulmonary venous flow, and Doppler tissue imaging indices were obtained, and LVEDP was measured invasively through cardiac catheterization.Results: The majority of the standard Doppler and Doppler tissue imaging indices were not significantly correlated with LVEDP in the univariate analysis. In the multiple linear regression, however, early (E transmitral velocity to annular E' (E/E' ratio (ß = 1.09, p value < 0.01, E wave velocity to propagation velocity (E/Vp ratio (ß = 7.87, p value < 0.01, and isovolumic relaxation time (ß = 0.21, p value = 0.01 were shown as independent predictors of LVEDP (R2 = 91.7%.Conclusion: The ratio of E/Vp and E/E' ratio and also the isovolumic relaxation time could be applied properly to estimate LVEDP in mitral regurgitation patients even in the setting of severe mitral regurgitation.

Mojtaba Salarifar

2010-08-01

95

Assessment of changes in left ventricular diastolic filling during dipyridamole infusion in patients with coronary artery disease  

International Nuclear Information System (INIS)

Twenty patients with ischemic heart disease (IHD) and 8 normal subjects underwent first-pass radionuclide ventriculography before and after dipyridamole tests. Hemodynamic parameters were evaluated in early and late diastolic phases. In the normal group, left ventricular ejection fraction (LVEF) increased after dipyridamole infusion. In addition, dipyridamole infusion was associated with an increase in left ventricular early filling time (FT) and early filling volume (FV) and a decrease in late FT and late FV. Left ventricular early peak filling rate (PFR) was significantly increased. In the IHD group, however, there was no significant change in LVEF. Both left ventricular early FT and early FV were decreased, and both late FT and late FV were increased. In the group of IHD patients, the time to early PFR was significantly prolonged, although there was no difference in early PFR, late PFR, and the ratio of early to late PFRs. These results indicate that dipyridamole infusion does not always induce a decrease in left ventricular contractile function in ischemic heart, but maintains the left ventricular FV by compensated mechanism of late filling ability for the decreased left ventricular early filling ability. (N.K.)

96

Effect of Noise Pollution on Arterial Blood Pressure and Heart Pulse Rate of Workers in the Hospitals of Nablus City-West Bank  

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This research is studying noise pollution effects on the healthcare professionals in Nablus city hospitals. The arterial systolic and diastolic blood pressure (SBP and DBP) and heart pulse rate were measured for 95 workers (55 males and 40 females) in the selected hospitals of Nablus city. The ages of the sample workers were ranging from 20 to 73 year. The Sound Pressure Level (SPL) values were first measured in all studied hospitals and were found to be high compared to the recommended...

Ashqer, I. R.; Qamhieh, Z. N.; Sadeq, R. M.

2013-01-01

97

Relationship between plasma BNP levels and left ventricular diastolic function as measured by radionuclide ventriculography in patients with coronary artery disease  

International Nuclear Information System (INIS)

Radionuclide ventriculography enables such parameters of the left ventricular (LV) function as the ejection fraction (EF), ejection rate (ER) and filling rate (FR) to be measured correctly. The impairment of the LV function in coronary artery disease (CAD) results in an increase in plasma brain natriuretic peptide (BNP). The aim of this study was to check whether the reduction of the average filling rate (AFR) leads to an increase in plasma BNP levels in patients with CAD and nEF and whether that increase is comparable to that occurring in subjects with a reduced PER. The study population comprised 69 patients with CAD and 18 healthy subjects - a control group (CG). In all cases radionuclide ventriculography was performed at rest and the plasma BNP level was estimated. The plasma BNP concentration was significantly higher in the group with CAD than in those with CG. In patients with CAD and a decreased LVEF (dEF), the BNP level was significantly higher than in those with normal LVEF (nEF). In the subgroup with nEF and an AFR ? 1.04 EDV/s, the level of plasma BNP was significantly higher than in that with an AFR >1.04. In the total CAD group, a significant correlation was found between plasma BNP concentrations and the LVEF, PER and AFR. In patients with nEF, the level of plasma BNP correlated only with the AFR. It is concluded that the diastolic dysfunction of the left ventricle in patients with CAD leads to an elevation of plasma BNP concentrations despite the normal ejection fraction. A diastolic dysfunction of the left ventricle affects the BNP plasma concentration to a greater degree than a systolic dysfunction. (author)

98

Changes in the retrobulbar arterial circulation after decrease of elevated intraocular pressure in patients with primary open angle glaucoma  

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Full Text Available Introduction. An altered perfusion of the optic nerve head has been proposed as a pathogenic factor in glaucoma. Objective. To evaluate changes of haemodynamic parameters in the retrobulbar arterial circulation after a decrease of elevated intraocular pressure (IOP in patients with primary open angle glaucoma (POAG. Methods. Twenty-six patients were examined, 14 men and 12 women, 21 up to 50 years old and 5 below, all with previously diagnosed and treated POAG, and all examined at the Eye Clinic, Clinical Centre of Serbia. IOP was measured both with a Goldmann aplanation tonometer and dynamic contour tonometer. Central corneal thickness was measured with ultrasound pachymeter. Imaging of the retrobulbar arterial circulation by colour Doppler was performed at the Neurology Clinic, Clinical Centre of Serbia. It involved measuring of haemodynamic parameters of the ophthalmic artery, central retinal artery, and posterior ciliary arteries. Peak systolic velocity (PSV and end-diastolic velocity (EDV were measured, and resistive index (RI and pulsatility index (PI were calculated. Results. Haemodynamic arterial parameters PSV and EDV in the ophthalmic and central retinal artery after decrease of IOP were lower, while RI and PI were higher. In the posterior ciliary arteries PSV, EDV and PI were lower, and RI was higher. Conclusion. Changes of the retrobulbar arterial circulation after elevated IOP in POAG patients are important for approach and treatment, while the role of vascular factors in the supplement of the optic disc neuroretinal rim could be a key for progression backlash of glaucoma and the radix of neuroprotection.

Kneževi? Miroslav

2011-01-01

99

DAILY BLOOD PRESSURE MONITORING AND ARTERIAL RIGIDITY DATA IN OSTEOARTHRITIS PATIENTS WITH AND WITHOUT ARTERIAL HYPERTENSION  

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Full Text Available We have compared the daily blood pressure monitoring data with arterial wall rigidity parameters in patients with osteoarthritis with and without arterial hypertension. In 32% of patients with osteoarthritis without arterial hypertension we have determined “non-dipper” type and in 16% of patients - “night-peaker”. In case of arterial hypertension 42,8% of patients with osteoarthritis have “night-peaker” type and 22,8% of patients have “non-dipper” type. We have found the correlation between augmentation indices and daily blood pressure parameters.

I.A. Kharitonova

2009-03-01

100

Harmonics tracking of intracranial and arterial blood pressure waves.  

Science.gov (United States)

Considering cardiorespiratory interaction and heart rate variability, a new approach is proposed to decompose intracranial pressure and arterial blood pressure to their different harmonics. The method is based on tracking the amplitudes of the harmonics by a Kalman filter based tracking algorithm. The algorithm takes benefit of combined frequency estimation technique which uses both Fast Fourier Transform and RR-interval detection. The result would be of use in intracranial pressure and arterial blood pressure waveform analysis as well as other investigations which need to estimate contribution of specific harmonic in above mentioned signals such as Pressure-Volume Compensatory Reserve assessment. PMID:19163248

Shahsavari, Sima; McKelvey, Tomas

2008-01-01

 
 
 
 
101

La hipertensión arterial en la tercera edad / High blood pressure in third age  

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Full Text Available SciELO Cuba | Language: Spanish Abstract in spanish A partir de la quinta o sexta décadas de la vida, la hipertensión arterial adopta formas y obedece a causas diferentes a las del niño o a las del adulto joven. En este caso, la presión arterial sistólica aumenta (> 140 mmHg) y la diastólica se mantiene o disminuye ([...] ión diferencial. La causa es la rigidez de las arterias de conductancia por la aterosclerosis y la acción de algunas hormonas como: adrenalina, noradrenalina, angiotensina II y aldosterona sobre la pared media arterial. El diagnóstico se hace constatando hipertensión sistólica aislada en pacientes mayores de 50 años. En jóvenes, además de la presión sistólica elevada con presión diastólica normal o baja, es conveniente medir otros indicadores de rigidez aórtica. La hipertensión sistólica en la tercera edad suele asociarse a: hipertrofia arterial y ventricular izquierda, disminución de la relajación de las paredes cardíacas y coronarias, isquemia miocárdica, nefrosclerosis, declinación cognoscitiva o incluso, demencia. El tratamiento requiere cuidados especiales y se debe adaptar a la frecuente comorbilidad de la edad avanzada. Los grupos antihipertensivos más efectivos, según ensayos al azar, son: los inhibidores de la enzima conversora de angiotensina, los bloqueadores de la angiotensina II, los antagonistas de la aldosterona y los bloqueadores de calcio. Los nitratos y los diuréticos se han empleado para reducir la presión sistólica, especialmente cuando concurre regurgitación valvular aórtica. La disminución de la presión sistólica, parece traer como consecuencia un retardo o detención de las complicaciones cardiovasculares, de la declinación cognoscitiva y de la demencia en pacientes de edad avanzada. Abstract in english From the fifth or sixth decades of life, high blood pressure adopts ways and is due to different causes to that of child or to that of young adult. In this case, systolic arterial pressure increases (> 140 mmHg), and the diastolic one remains or decreases ([...] ases. The cause is conduction artery stiffness by atherosclerosis as well as the action of some hormones including: adrenaline, noradrenaline, agiotensin II, and aldosterone on the arterial medium wall. Diagnosis is made verifying presence of an isolated systolic high blood pressure in patients aged over 50. In youngest, in addition to high systolic pressure with a normal or low diastolic pressure, it is advisable measurement of others indicators of aortic stiffness. Systolic pressure in third age may to be associated with: left ventricular and arterial hypertrophy, a relaxation decrease of cardiac and coronary walls, myocardial ischemia, nephroesclerosis, cognitive decline or even dementia. Treatment requires special cares and must to adjust to the frequent morbidity of old age. The more effective antihypertensive groups according to randomized assays include: agiotensin-converting enzyme (ACE) inhibitors, agiotensin II blockers, aldosterone antagonists, and calcium blockers. Nitrates and diuretic agents have been used to reduce systolic pressure, especially when there is an aortic valvular regurgitation. Decrease of systolic pressure to result in a delay or an arrest of cardiovascular complications, of cognitive decline, and dementia in third age patients.

David, García Barreto; Julio, Álvarez González; Raymid, García Fernández; Juan, Valiente Mustelier; Alberto, Hernández Cañero.

102

Effect of ethanol consumption on blood pressure and rat mesenteric arterial bed, aorta and carotid responsiveness.  

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This study investigates whether chronic ethanol consumption increases blood pressure and alters vascular reactivity in different tissues. Changes in reactivity to phenylephrine and acetylcholine were investigated in the aorta, carotid artery and mesenteric arterial bed (MAB) isolated from rats pretreated with ethanol for 2 or 6 weeks. Mild hypertension was observed in chronically ethanol-treated rats, which was due to rises in both systolic and diastolic pressures. Chronic ethanol consumption increased the contractile response to phenylephrine of endothelium-intact and denuded rat aortic rings from rats pretreated with ethanol for 2 or 6 weeks. Conversely, no differences were found in acetylcholine-induced relaxation. Neither phenylephrine-induced contraction nor acetylcholine-induced relaxation were altered in the rat carotid. Six weeks' ethanol consumption enhanced the contractile response to phenylephrine of endothelium-intact, but not denuded rat MAB. On the other hand, 2 weeks' ethanol consumption did not affect phenylephrine-induced increase in perfusion pressure. Moreover, acetylcholine-induced endothelium-dependent relaxation in the MAB was reduced after treatment with ethanol for 6 weeks but not after 2 weeks. In conclusion, ethanol affects both blood pressure and vessel reactivity, but the effect on vascular reactivity may take longer to become apparent in MAB than in the aorta, and was not evident in the carotid. Moreover, we provide evidence that the effect of ethanol depends on the agonist and blood vessel studied. PMID:17637194

Tirapelli, Carlos R; Leone, Andreia F C; Coelho, Eduardo B; Resstel, Leonardo B M; Corrêa, Fernando M A; Lanchote, Vera L; Uyemura, Sergio A; Padovan, Cláudia M; de Oliveira, Ana M

2007-07-01

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Increased dependence on slow filling for left ventricular diastolic filling in patients with coronary artery disease and a depressed systolic function; Assessement with radionuclide ventriculography  

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Contributions of rapid filling, slow filling and atrial systole to the left ventricular(LV) filling volume were analyzed with the use of radionuclide ventriculography at rest, both globally and regionally, in 34 patients with isolated disease of the left anterior descending coronary artery. The patients included 17 with a normal ejection fraction (EF{ge}50%; group 1) and 17 with a depressed EF (<50%; group 2), and the data were compared with those obtained from 13 normal subjects. A computer program subdivided the LV image into 4 regions, and time-activity curves were constructed globally and regionally by reverse-gating from the R wave. In both groups the contribution of rapid filling to the LV filling volume was decreased significantly in the affected septal and apical regions, and in the global left ventricle compared with that in normal subjects. In group 1, the contribution of atrial systole showed an increase in these affected regions and in the global left ventricle. In contrast, in group 2, the atrial contribution was not increased globally or regionally as much as was expected. However, the contribution of slow filling was either increased significantly or tended to increase in the affected regions and in the global left ventricle. There were negative correlations between the contribution of rapid filling and that of slow filling in the global left ventricle (r=-0.73, p<0.001) and in each of the septal, apical and lateral regions (r{ge}-0.60, p<0.001), which suggested that the contribution of slow filling as well as of atrial systole undergoes an increase as rapid filling is impaired. Thus, in patients with coronary artery disease, the left ventricle relies on slow filling as well as atrial systole to affect diastolic LV filling in the affected regions and in the global left ventricle in the presence of LV systolic dysfunction. (author).

Yamagishi, Takashi; Ozaki, Masaharu; Furutani, Yuhji; Yamamoto, Kouzo; Saeki, Atsushi; Satoh, Shinichi; Kusukawa, Reizo (Yamaguchi Univ., Ube (Japan). School of Medicine)

1990-04-01

104

Differential impact of belatacept and cyclosporine A on central aortic blood pressure and arterial stiffness after renal transplantation.  

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Calcineurin inhibitors (CNI) are potent vasoconstrictors and induce an acceleration of arteriosclerosis, thus contributing to the cardiovascular risk after renal transplantation. The study compares the impact of belatacept and cyclosporine A (CsA) on arterial stiffness and central aortic blood pressure. We performed a case-control study in 46 patients (23 on belatacept and 23 on CsA) matched for age, body mass index, time after transplantation, and time on dialysis prior to transplantation. Pulse wave analysis (SphygmoCor, AtCor(®) ) was used to assess central aortic blood pressure, aortic augmentation pressure, and pulse wave velocity (PWV) as a marker of arterial stiffness. Assessment of vascular function was performed after a minimum of 20 months and a median follow-up of 81 months post-transplant. Peripheral systolic and diastolic blood pressure did not significantly differ in the two groups (p > 0.05 each). The central aortic augmentation pressure was higher in the CsA group (12.7 mmHg vs. 7.3 mmHg, p = 0.048). PWV as a measure of arterial stiffness did not differ in the two groups. Thus, belatacept is not associated with a significant difference in arterial stiffness compared to CsA after a median of 81 months post-transplant. It is associated, however, with a lower aortic augmentation pressure, a strong independent cardiovascular risk factor. PMID:24974984

Seibert, Felix S; Steltzer, Julia; Melilli, Eduardo; Grannas, Gerrit; Pagonas, Nikolaos; Bauer, Frederic; Zidek, Walter; Grinyó, Josep; Westhoff, Timm H

2014-09-01

105

Hyperglycemia and nocturnal systolic blood pressure are associatedwith left ventricular hypertrophy and diastolic dysfunction in hypertensive diabetic patients  

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Abstract Background The aim of this study was to determine if hypertensive type 2 diabetic patients, when compared to patients with essential hypertension have an increased left ventricular mass index (LVMI) and a worse diastolic function, and if this fact would be related to 24-h pressoric levels changes. Methods Ninety-one hypertensive patients with type 2 diabetes mellitus (DM) (group-1 [G1]), 59 essential hypertensive patients (group-2 [G2]) and 26 healthy c...

Felício João S; Pacheco Juliana T; Ferreira Sandra R; Plavnik Frida; Moisés Valdir A.; Kohlmann Oswaldo; Ribeiro Artur B; Zanella Maria T

2006-01-01

106

Relation of the systemic blood pressure to the collateral pressure distal to an infarct-related coronary artery occlusion during acute myocardial infarction.  

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Collaterals to occluded coronary arteries have been observed early after the onset of acute myocardial infarction (AMI). The pressure distal to the occluded segment of the culprit coronary artery (P(d)) is generated by collateral flow from the feeding coronary artery supplied by the systemic circulation. The aim of the study was to assess the relation between systemic blood pressure (BP) and P(d). Systemic BP and P(d) were measured simultaneously during intervention of totally occluded coronary arteries in 152 patients admitted for AMI. Patients were divided into groups by time from symptom onset to P(d) measurement. There was a significant positive correlation between P(d) and the systolic, diastolic, and mean BPs measured during the first 3 hours from symptom onset (n = 60; p 12 hours after symptom onset (n = 36; p <0.003 for all). The collateral flow, represented by calculated collateral flow index (mean 0.37 ± 0.14, median 0.36), was correlated with mean BP (p = 0.05) but not with diastolic or systolic BP (p = NS) in the overall study population. A direct relation was established during AMI between systemic BP and P(d) at all time intervals from symptom onset. Collateral flow index correlated with mean BP and was strongly associated with P(d) at all time intervals. In conclusion, the relation between P(d) and systemic BP suggests caution when administering therapy that may lower systemic BP during AMI before restoring flow in the occluded culprit artery, as it may compromise collateral pressure and exacerbate myocardial ischemia. PMID:23178051

Meisel, Simcha Ron; Frimerman, Aaron; Blondheim, David Simeon; Shotan, Avraham; Asif, Aya; Shani, Jacob; Rozenman, Yoseph; Shochat, Michael

2013-02-01

107

Noninvasive Measurement of Central Vascular Pressures With Arterial Tonometry: Clinical Revival of the Pulse Pressure Waveform?  

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The arterial pulse has historically been an essential source of information in the clinical assessment of health. With current sphygmomanometric and oscillometric devices, only the peak and trough of the peripheral arterial pulse waveform are clinically used. Several limitations exist with peripheral blood pressure. First, central aortic pressure is a better predictor of cardiovascular outcome than peripheral pressure. Second, peripherally obtained blood pressure does not accurately reflect c...

Nelson, Matthew R.; Stepanek, Jan; Cevette, Michael; Covalciuc, Michael; Hurst, R. Todd; Tajik, A. Jamil

2010-01-01

108

Effects of smoking cessation on central blood pressure and arterial stiffness  

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Full Text Available Takeshi Takami1,Yoshihiko Saito21Department of Internal Medicine, Clinic Jingumae, Kashihara, Nara, Japan; 2First Department of Internal Medicine, Nara Medical University, Kashihara, Nara, JapanPurpose: Smoking affects arterial stiffness, thus causing an elevation in central blood pressure (CBP. The present study was designed to examine whether smoking cessation treatment improved CBP and arterial stiffness.Patients and methods: We conducted an observational study of 70 patients receiving smoking cessation treatment. Before and 60 weeks after the start of a 12-week varenicline treatment, we measured brachial blood pressure, CBP, brachial-ankle pulse wave velocity (baPWV, normalized radial augmentation index (rAIx@75, left ventricular weight, and left ventricular diastolic function of each patient. The data were compared between the patients who succeeded in quitting smoking (smoking cessation group; n = 37 and those who failed to quit smoking (smoking group; n = 33.Results: Baseline characteristics were similar in both groups. Brachial blood pressure remained unchanged in both groups. CBP, baPWV, and rAIx@75 decreased significantly in the smoking cessation group, while these parameters showed no significant change in the smoking group. Thus, CBP, baPWV, and rAIx@75 showed greater decrease in the smoking cessation group than in the smoking group (CBP, ?7.1 ± 1.4 mmHg vs 1.2 ± 2.7 mmHg; P < 0.01; baPWV, ?204 ± 64 cm/s vs ?43 ± 72 cm/s; P < 0.01; rAIx@75, ?6.4 ± 2.8% vs ?1.0 ± 3.9%; P < 0.01. Left ventricular weight and left ventricular diastolic function remained unchanged in both groups.Conclusion: Patients in the smoking cessation group showed significant improvement in CBP, baPWV, and rAIx@75. These results indicate that smoking cessation can improve arterial stiffness and CBP.Keywords: central blood pressure, augmentation index, brachial-ankle pulse wave velocity, smoking cessation, varenicline

Takami T

2011-10-01

109

Longitudinal perspective on the conundrum of central arterial stiffness, blood pressure, and aging.  

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The age-associated increase in arterial stiffness has long been considered to parallel or to cause the age-associated increase in blood pressure (BP). Yet, the rates at which pulse wave velocity (PWV), a measure of arterial stiffness, and BP trajectories change over time within individuals who differ by age and sex have not been assessed and compared. This study determined the evolution of BP and aortic PWV trajectories during a 9.4-year follow-up in >4000 community-dwelling men and women of 20 to 100 years of age at entry into the SardiNIA Study. Linear mixed effects model analyses revealed that PWV accelerates with time during the observation period, at about the same rate over the entire age range in both men and women. In men, the longitudinal rate at which BP changed over time, however, did not generally parallel that of PWV acceleration: at ages >40 years the rates of change in systolic BP (SBP) and pulse pressure (PP) increase plateaued and then declined so that SBP, itself, also declined at older ages, whereas PP plateaued. In women, SBP, diastolic BP, and mean BP increased at constant rates across all ages, producing an increasing rate of increase in PP. Therefore, increased aortic stiffness is implicated in the age-associated increase in SBP and PP. These findings indicate that PWV is not a surrogate for BP and that arterial properties other than arterial wall stiffness that vary by age and sex also modulate the BP trajectories during aging and lead to the dissociation of PWV, PP, and SBP trajectories in men. PMID:25225210

Scuteri, Angelo; Morrell, Christopher H; Orrù, Marco; Strait, James B; Tarasov, Kirill V; Ferreli, Liana Anna Pina; Loi, Francesco; Pilia, Maria Grazia; Delitala, Alessandro; Spurgeon, Harold; Najjar, Samer S; AlGhatrif, Majd; Lakatta, Edward G

2014-12-01

110

Early diastolic filling dynamics in diastolic dysfunction  

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Full Text Available Abstract Background The aim of the study was to determine the relationship between the rate of peak early mitral inflow velocity and the peak early diastolic mitral annular tissue velocities in normal controls and to compare them with subjects with diastolic dysfunction. Methods The relationship between early passive diastolic transmitral flow and peak early mitral annular velocity in the normal and in diastolic dysfunction was studied. Two groups comprising 22 normal controls and 25 patients with diastolic dysfunction were studied. Results Compared with the normal group, those with diastolic dysfunction had a lower E/A ratio (0.7 ± 0.2 vs. 1.9 ± 0.5, p 2 vs. 871 ± 128.1 cm/sec2, p Conclusions This investigation provides information on the acceleration of early diastolic filling and its relationship to mitral annular peak tissue velocity (Ea recorded by Doppler tissue imaging. It supports not only the premise that recoil is an important mechanism for rapid early diastolic filling but also the existence of an early diastolic mechanism in normal.

Crean Peter A

2003-07-01

111

Felipressina aumenta pressão arterial durante procedimento odontológico em pacientes hipertensos Felypressin increases blood pressure during dental procedures in hypertensive patients  

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Full Text Available FUNDAMENTO: A felipressina foi adicionada ao anestésico local para aumentar a duração do efeito anestésico e reduzir a toxicidade nos procedimentos dentários. No entanto, o efeito sobre a pressão arterial é incerta, e isso pode ser altamente relevante no tratamento dentário de pacientes hipertensos. OBJETIVO: Investigar o efeito da felipressina sobre a pressão arterial em pacientes hipertensos com pressão arterial controlada. MÉTODOS: Foram estudados 71 indivíduos com essas características e com necessidade de tratamento periodontal. Após 10 minutos de repouso, a anestesia local (prilocaína foi infiltrada com e sem adição de felipressina. Em seguida, uma raspagem subgengival profunda foi realizada. A pressão arterial foi medida por um equipamento oscilométrico automático (DIXTAL DX2010. Dez minutos após a administração do anestésico, o pico de ação anestésica foi gravado. O Inventário de Ansiedade Traço-Estado (IDATE foi utilizado para avaliar o traço de ansiedade nos pacientes. RESULTADOS: A pressão arterial sistólica aumentou após a anestesia, independentemente da associação com felipressina, durante todo o procedimento dentário (p BACKGROUND: Felypressin has been added to local anesthetic to increase the length of the anesthetic effect and reduce toxicity during dental procedures. However, the effect on blood pressure remains uncertain, and this may be highly relevant in the dental treatment of hypertensive patients. OBJECTIVE: To investigate the effect of felypressin on blood pressure in hypertensive patients with controlled BP. METHODS: 71 subjects with these characteristics and in need of periodontal treatment were studied. After 10 minutes of rest, local anesthesia (prilocaine was infiltrated with and without addition of felypressin. Then, a deep subgingival scaling was performed. Blood pressure was measured by an automated oscillometric device (DIXTAL DX2010. Ten minutes after the administration of the anesthetic, peak anesthetic action was recorded. The State-Trait Anxiety Inventory (STAI was used to assess the patients' trait anxiety. RESULTS: Systolic blood pressure increased after anesthesia, regardless of association with felypressin, throughout the dental procedure (p<0.05 and this response can be explained, at least in part, by the trait anxiety levels of the subjects. However, a further increase in diastolic blood pressure was observed when prilocaine was associated with felypressin (p<0.05, but this response did not change with trait anxiety levels. CONCLUSION: Felypressin increased the diastolic blood pressure of hypertensive patients with controlled blood pressure. Patients with high trait anxiety presented increases in systolic blood pressure upon some procedures, suggesting that an increase in blood pressure might also be related to fear or anxiety.

Ana Lúcia Aparecida Bronzo

2012-08-01

112

Assembly of a Pulmonary Artery Pressure Sensor System  

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Full Text Available This paper presents an implantable system for telemonitoring the intravascular pressure in the pulmonary artery. By implanting a catheter-bound pressure and temperature sensor into the pulmonary artery, it is possible to monitor the actual value and the time variations of the intravascular pressure with a frequency of 128 Hz. Thus hospitalization of patients suffering from heart insufficiency can be avoided by early changes in therapy.Preliminary in vivo experiments have been conducted to verify the fixation mechanism and the positioning of the sensor at the right place in the pulmonary artery. It was shown that the proposed fixation mechanism and the packaging of the sensor promise to be stable.

J. Müntjes

2010-01-01

113

[Thoughts concerning the realms of arterial blood pressure].  

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Several realms of arterial blood pressure are analyzed. 1. The realm of physiological regulation of arterial blood pressure is discussed from the point of view of an intelligent design. 2. The realm of biophysical consequences, the adverse effects, wearing off or senilization and the vascular accidents. 3. The realm of biochemical changes leading to cellular changes. The ecological equilibrium and the interpretation of purposeful reactions. From metaphore to purpose. 4. The realm of cellular changes as a result of biophysical factors. The society of cells. 5. The realm of metabolic environment. 6. The realm of adverse effects of increasing arterial blood pressure instead of selecting less risky mechanisms. A politically mistaken decision. PMID:11188910

Agrest, A

2000-01-01

114

Effects of verapamil and propranolol on left ventricular systolic function and diastolic filling in patients with coronary artery disease: radionuclide angiographic studies at rest and during exercise  

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ved by verapamil, LV diastolic filling is enhanced by verapamil, both at rest and during exercise. These mechanisms may account in part for the symptomatic improvement in many patients during verapamil therapy

115

Medial circumflex femoral artery flap for ischial pressure sore  

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Full Text Available A new axial pattern flap based on the terminal branches of the medial circumflex femoral artery is described for coverage of ischial pressure sore. Based on the terminal branches of the transverse branch of medial circumflex femoral artery, which exit through the gap between the quadratus femoris muscle above and the upper border of adductor magnus muscle below, this fascio cutaneous flap is much smaller than the posterior thigh flap but extremely useful to cover ischeal pressure sores. The skin redundancy below the gluteal fold allows a primary closure of the donor defect. It can also be used in combination with biceps femoris muscle flap.

Palanivelu S

2009-01-01

116

Dança de salão: respostas crônicas na pressão arterial de hipertensos medicados / Ballroom dance: chronic responses on blood pressure in medicated hypertensives  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese A importância da prática de exercícios físicos para portadores de hipertensão arterial sistêmica está bem estabelecida na literatura, entretanto, a Dança de Salão, neste contexto, tem sido pouco explorada. O objetivo do estudo foi verificar o efeito crônico da prática de dança de salão sobre a press [...] ão arterial sistêmica de hipertensos medicados. Considerou-se como amostra o número de medidas obtidas da pressão arterial dos pacientes durante a participação no programa de dança. Assim, 92 medidas da pressão arterial foram realizadas, sendo divididas em quatro grupos: 1) pressão arterial sistólica pré-programa; 2) pressão arterial sistólica pós-programa; 3) pressão arterial diastólica pré-programa e; 4) pressão arterial diastólica pós-programa. Utilizaram-se esfigmomanômetro de coluna de mercúrio e estetoscópio. Considerou-se o protocolo de mensuração da Diretriz Brasileira. A pressão arterial foi aferida antes e após cada sessão de dança. Os 23 hipertensos medicados estudados tinham idade média de 62,5±7 anos e 34,8% eram do sexo masculino. Quarenta sessões de dança foram realizadas, três vezes/semana, com duração de uma hora/sessão. O valor médio da pressão arterial sistólica pré-programa foi de 131,8±17mmHg e após 117,8±13mmHg com diferença estatística significativa (p Abstract in english The importance of physical exercise for patients with systemic hypertension is well established in the literature. However, ballroom dance has been little investigated in this context. The objective of this study was to determine the chronic effect of ballroom dance on blood pressure in medicated hy [...] pertensives. The sample was the number of blood pressure measurements obtained during the patients' participation in the dance program. Thus, 92 blood pressure measurements were taken and divided into four groups: 1) pre-session systolic blood pressure, 2) post-session systolic blood pressure, 3) pre-session diastolic blood pressure, 4) post-session diastolic blood pressure. We used a mercury sphygmomanometer and stethoscope. As measuring protocol, we considered the Brazilian Guidelines. Blood pressure was measured before and after each ballroom dance session. The mean age of the 23 medicated hypertensive patients studied was 62.5 ± 7 years and 34.8% of them were male. Forty sessions were held three times a week, lasting one hour/session. The mean pre-session systolic blood pressure was 131,8 ± 17mmHg and 117,8±13mmHg after the session, with statistically significant difference (p

Fernanda Christina de Souza, Guidarini; Isabel de Castro, Schenkel; Victor Carvalho, Kessler; Tânia Rosane Bertoldo, Benedetti; Tales de, Carvalho.

2013-04-01

117

Altered diastolic function and aortic stiffness in Alzheimer's disease  

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Background Alzheimer’s disease (AD) is closely linked to cardiovascular risk factors. Methods Echocardiographic studies were performed, including left ventricular diastolic functions, left and right atrial conduction times, and arterial stiffness parameters, namely stiffness index, pressure-strain elastic modulus, and distensibility, on 29 patients with AD and 24 age-matched individuals with normal cognitive function. Results The peak mitral flow velocity of the early rapid filling wave (E) was lower, and the peak velocity of the late filling wave caused by atrial contraction (A), deceleration time of peak E velocity, and isovolumetric relaxation time were higher in the AD group. The early myocardial peak (Ea) velocity was significantly lower in AD patients, whereas the late diastolic (Aa) velocity and E/Ea ratio were similar between the two groups. In Alzheimer patients, stiffness index and pressure-strain elastic modulus were higher, and distensibility was significantly lower in the AD group compared to the control. Interatrial electromechanical delay was significantly longer in the AD group. Conclusion Our findings suggest that patients with AD are more likely to have diastolic dysfunction, higher atrial conduction times, and increased arterial stiffness compared to the controls of same sex and similar age. PMID:25075180

Cal?k, Ali Nazmi; Ozcan, Kaz?m Serhan; Yuksel, Gulbun; Gungor, Bar?ss; Arugarslan, Emre; Varlibas, Figen; Ekmekci, Ahmet; Osmonov, Damirbek; Tatl?su, Mustafa Adem; Karaca, Mehmet; Bolca, Osman; Erdinler, Izzet

2014-01-01

118

The power combination of blood-pressure parameters to predict the incidence of plaque formation in carotid arteries in elderly  

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Hypertension is considered as one of the major risk factors of atherosclerosis, especially for carotid artery plaque, which is a sign for cardiovascular incapacity and cerebral infarction. As adult age, systolic blood pressure (SBP or S) tends to rise and diastolic blood pressure (DBP or D) tends to fall, thus the pulse pressure (PP) will increase. The vascular injury was directly proportional to the level of SBP, and inversely proportional to DBP. But so far, studies of the vascular injury based on SBP and DBP measurement were mostly qualitative. The exact contribution of each parameter to the vascular injury has not been quantitatively identified. In this study, we employed a mathematical model to predict the risk for plaques of carotid arteries in aged people and combined the SBP, DBP and heart rate (HR) to perform a quantitative analysis. We analyzed 1672 males who were over 60-year-old and hospitalized due to atherosclerosis-related diseases and received a 24-h arterial blood pressure monitoring (ABPM) examination. These patients were divided into 19 subgroups using the ABPM data, 24-h average SBP, DBP and HR as variables based on the ascending order of the magnitude of each element. We developed a new index, namely the dynamic level (DL) which correlated best with the plaque formation of carotid arteries among all the well-established indexes for blood pressure. We demonstrated that index DL has better correlation to plaques incidence tendency (p < 0.0001) when compared to either SBP (P < 0.05) or PP (P < 0.001) alone. The risk on incidence of the plaques of carotid arteries has positive correlation with first power of SBP and -0.8 power of DBP. This model can be used clinically to predict the occurrence of plaque formation. PMID:23844270

Hao, Chang-Ning; Shi, Yi-Qin; Huang, Jing-Juan; Li, Hao-Yun; Huang, Zhen-Hao; Cheng, Xian-Wu; Lu, Wei; Duan, Jun-Li

2013-01-01

119

Impact of age on the importance of systolic and diastolic blood pressures for stroke risk : the MOnica, Risk, Genetics, Archiving, and Monograph (MORGAM) Project  

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This study investigates age-related shifts in the relative importance of systolic (SBP) and diastolic (DBP) blood pressures as predictors of stroke and whether these relations are influenced by other cardiovascular risk factors. Using 34 European cohorts from the MOnica, Risk, Genetics, Archiving, and Monograph (MORGAM) Project with baseline between 1982 and 1997, 68 551 subjects aged 19 to 78 years, without cardiovascular disease and not receiving antihypertensive treatment, were included. During a mean of 13.2 years of follow-up, stroke incidence was 2.8%. Stroke risk was analyzed using hazard ratios per 10-mm Hg/5-mm Hg increase in SBP/DBP by multivariate-adjusted Cox regressions, including SBP and DBP simultaneously. Because of nonlinearity, DBP was analyzed separately for DBP ? 71 mm Hg and DBP

Vishram, Julie K K; Borglykke, Anders Rething

2012-01-01

120

Impact of Age on the Importance of Systolic and Diastolic Blood Pressures for Stroke Risk : The MOnica, Risk, Genetics, Archiving, and Monograph (MORGAM) Project  

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This study investigates age-related shifts in the relative importance of systolic (SBP) and diastolic (DBP) blood pressures as predictors of stroke and whether these relations are influenced by other cardiovascular risk factors. Using 34 European cohorts from the MOnica, Risk, Genetics, Archiving, and Monograph (MORGAM) Project with baseline between 1982 and 1997, 68 551 subjects aged 19 to 78 years, without cardiovascular disease and not receiving antihypertensive treatment, were included. During a mean of 13.2 years of follow-up, stroke incidence was 2.8%. Stroke risk was analyzed using hazard ratios per 10-mm Hg/5-mm Hg increase in SBP/DBP by multivariate-adjusted Cox regressions, including SBP and DBP simultaneously. Because of nonlinearity, DBP was analyzed separately for DBP ?71 mm Hg and DBP

Vishram, Julie K K; Borglykke, Anders

2012-01-01

 
 
 
 
121

Optimal perioperative management of arterial blood pressure  

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Full Text Available Laurent Lonjaret,1 Olivier Lairez,2 Vincent Minville,3 Thomas Geeraerts3 1Department of Anesthesiology and Intensive Care, Clinique des eaux claires, Baie-Mahault, France; 2Department of Cardiology, 3Department of Anesthesiology and Intensive Care, University Hospital of Toulouse, University Toulouse III - Paul Sabatier, Toulouse, France Abstract: Perioperative blood pressure management is a key factor of patient care for anesthetists, as perioperative hemodynamic instability is associated with cardiovascular complications. Hypertension is an independent predictive factor of cardiac adverse events in noncardiac surgery. Intraoperative hypotension is one of the most encountered factors associated with death related to anesthesia. In the preoperative setting, the majority of antihypertensive medications should be continued until surgery. Only renin-angiotensin system antagonists may be stopped. Hypertension, especially in the case of mild to moderate hypertension, is not a cause for delaying surgery. During the intraoperative period, anesthesia leads to hypotension. Hypotension episodes should be promptly treated by intravenous vasopressors, and according to their etiology. In the postoperative setting, hypertension predominates. Continuation of antihypertensive medications and postoperative care may be insufficient. In these cases, intravenous antihypertensive treatments are used to control blood pressure elevation. Keywords: hypertension, hypotension, perioperative, blood pressure control

Lonjaret L

2014-09-01

122

Comparison of approaches to quantify arterial damping capacity from pressurization tests on mouse conduit arteries.  

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Large conduit arteries are not purely elastic, but viscoelastic, which affects not only the mechanical behavior but also the ventricular afterload. Different hysteresis loops such as pressure-diameter, pressure-luminal cross-sectional area (LCSA), and stress-strain have been used to estimate damping capacity, which is associated with the ratio of the dissipated energy to the stored energy. Typically, linearized methods are used to calculate the damping capacity of arteries despite the fact that arteries are nonlinearly viscoelastic. The differences in the calculated damping capacity between these hysteresis loops and the most common linear and correct nonlinear methods have not been fully examined. The purpose of this study was thus to examine these differences and to determine a preferred approach for arterial damping capacity estimation. Pressurization tests were performed on mouse extralobar pulmonary and carotid arteries in their physiological pressure ranges with pressure (P) and outer diameter (OD) measured. The P-inner diameter (ID), P-stretch, P-Almansi strain, P-Green strain, P-LCSA, and stress-strain loops (including the Cauchy and Piola-Kirchhoff stresses and Almansi and Green strains) were calculated using the P-OD data and arterial geometry. Then, the damping capacity was calculated from these loops with both linear and nonlinear methods. Our results demonstrate that the linear approach provides a reasonable approximation of damping capacity for all of the loops except the Cauchy stress-Almansi strain, for which the estimate of damping capacity was significantly smaller (22 ± 8% with the nonlinear method and 31 ± 10% with the linear method). Between healthy and diseased extralobar pulmonary arteries, both methods detected significant differences. However, the estimate of damping capacity provided by the linear method was significantly smaller (27 ± 11%) than that of the nonlinear method. We conclude that all loops except the Cauchy stress-Almansi strain loop can be used to estimate artery wall damping capacity in the physiological pressure range and the nonlinear method is recommended over the linear method. PMID:24231965

Tian, Lian; Wang, Zhijie; Lakes, Roderic S; Chesler, Naomi C

2013-05-01

123

Genetic Associations With Hypoxemia and Pulmonary Arterial Pressure in COPD*  

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Background Hypoxemia, hypercarbia, and pulmonary arterial hypertension are known complications of advanced COPD. We sought to identify genetic polymorphisms associated with these traits in a population of patients with severe COPD from the National Emphysema Treatment Trial (NETT). Methods In 389 participants from the NETT Genetics Ancillary Study, single-nucleotide polymorphisms (SNPs) were genotyped in five candidate genes previously associated with COPD susceptibility (EPHX1, SERPINE2, SFTPB, TGFB1, and GSTP1). Linear regression models were used to test for associations among these SNPs and three quantitative COPD-related traits (Pao2, Paco2, and pulmonary artery systolic pressure). Genes associated with hypoxemia were tested for replication in probands from the Boston Early-Onset COPD Study. Results In the NETT Genetics Ancillary Study population, SNPs in microsomal epoxide hydrolase (EPHX1) [p = 0.01 to 0.04] and serpin peptidase inhibitor, clade E, member 2 (SERPINE2) [p = 0.04 to 0.008] were associated with hypoxemia. One SNP within surfactant protein B (SFTPB) was associated with pulmonary artery systolic pressure (p = 0.01). In probands from the Boston Early-Onset COPD Study, SNPs in EPHX1 and in SERPINE2 were associated with the requirement for supplemental oxygen. Conclusions In participants with severe COPD, SNPs in EPHX1 and SERPINE2 were associated with hypoxemia in two separate study populations, and SNPs from SFTPB were associated with pulmonary artery pressure in the NETT participants. PMID:19017876

Castaldi, Peter J.; Hersh, Craig P.; Reilly, John J.; Silverman, Edwin K.

2010-01-01

124

Epworth's sleepiness scale in outpatients with different values of arterial blood pressure  

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Full Text Available OBJECTIVE: To compare sleepiness scores of the Epworth scale in patients with different levels of arterial pressure when undergoing outpatient monitoring within the context of clinical evaluation. METHODS: A total of 157 patients selected for outpatient monitoring of arterial pressure during hypertension evaluation were divided into 3 groups: group 1 - normotensive; group 2 - hypertensive; group 3 - resistant hypertensive. For analysis, values > or = 11 were considered as associated with respiratory disturbances during sleep. RESULTS: Seventeen (10.8% patients in group 1, 112 (71.3% in group 2, and 28 (17.8% in group 3, which was composed of aged, more severely hypertensive individuals, were analyzed. Groups were similar relative to sex and body mass index, but different in relation to systolic and diastolic pressure levels and age. Despite an absolute difference, no statistically significant difference occurred between Epworth scores and in the proportion of patients with values > or = 11 (5.9% vs. 18.8% vs. 212.4%; P=0.37. Despite the positive association between degree of sleepiness measured with the scale and the severity of the hypertension, no statistical significance occurred following control by age (p=0.18. CONCLUSION: A positive correlation exists between degree of sleepiness and hypertension severity. The absence of a statistical significance shown in the present study could be due to a beta type of error. Instruments that render this complaint into an objective finding could help in the pursuit of an investigation of respiratory disturbances during sleep in more severely hypertensive patients, and should therefore be studied better.

Gus Miguel

2002-01-01

125

Epworth's sleepiness scale in outpatients with different values of arterial blood pressure  

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Full Text Available SciELO Brazil | Language: English Abstract in english OBJECTIVE: To compare sleepiness scores of the Epworth scale in patients with different levels of arterial pressure when undergoing outpatient monitoring within the context of clinical evaluation. METHODS: A total of 157 patients selected for outpatient monitoring of arterial pressure during hyperte [...] nsion evaluation were divided into 3 groups: group 1 - normotensive; group 2 - hypertensive; group 3 - resistant hypertensive. For analysis, values > or = 11 were considered as associated with respiratory disturbances during sleep. RESULTS: Seventeen (10.8%) patients in group 1, 112 (71.3%) in group 2, and 28 (17.8%) in group 3, which was composed of aged, more severely hypertensive individuals, were analyzed. Groups were similar relative to sex and body mass index, but different in relation to systolic and diastolic pressure levels and age. Despite an absolute difference, no statistically significant difference occurred between Epworth scores and in the proportion of patients with values > or = 11 (5.9% vs. 18.8% vs. 212.4%; P=0.37). Despite the positive association between degree of sleepiness measured with the scale and the severity of the hypertension, no statistical significance occurred following control by age (p=0.18). CONCLUSION: A positive correlation exists between degree of sleepiness and hypertension severity. The absence of a statistical significance shown in the present study could be due to a beta type of error. Instruments that render this complaint into an objective finding could help in the pursuit of an investigation of respiratory disturbances during sleep in more severely hypertensive patients, and should therefore be studied better.

Miguel, Gus; Daniel Nunes e, Silva; Juliana, Fernandes; Caroline P., Cunha; Geraldo Druck, Sant' Anna.

126

Treinamento resistido controla a pressão arterial de ratos hipertensos induzidos por l-NAME Resistance training controls arterial blood pressure in rats with L-NAME- induced hypertension  

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Full Text Available FUNDAMENTO: A hipertensão arterial é uma síndrome multifatorial, crônica, causada tanto por fatores congênitos ou adquiridos. OBJETIVO: Avaliar os efeitos do treinamento físico resistido (TR sobre pressão arterial, reatividade e morfologia vascular de ratos hipertensos induzidos por L-NAME. MÉTODOS: Ratos Wistar machos (200-250 g foram divididos em 3 grupos: normotenso sedentário (NS, hipertenso sedentário (HS e hipertenso treinado (HT. A hipertensão foi induzida pela administração de L-NAME (40 mg/kg na água de beber por 4 semanas. A pressão arterial foi avaliada antes e após o TR. O TR foi realizado utilizando 50% de 1RM, em 3 séries de 10 repetições, 3 vezes por semana, durante quatro semanas. A reatividade vascular foi mensurada em artéria mesentérica superior por curvas concentração resposta ao nitroprussiato de sódio (NPS e fenilefrina (FEN. Além disso, foram realizadas análises histológicas e estereológicas. RESULTADOS: O TR inibiu o aumento das pressões arteriais média e diastólica. Foi observada uma redução significativa na resposta máxima e na potência da FEN entre os grupos HS e HT. A análise histológica evidenciou aspecto normal para as túnicas íntima, média e adventícia em todos os grupos. Não houve diferença significativa nas áreas do lúmen, da túnica média e total das artérias dos grupos HS e HT em relação ao NS. A razão parede/lúmen arterial do grupo HS apresentou diferença significativa em relação ao NS (p BACKGROUND: Arterial hypertension is a multifactorial chronic condition caused by either congenital or acquired factors. OBJECTIVE: To evaluate the effects of Resistance Training (RT on arterial pressure, and on vascular reactivity and morphology, of L-NAME-treated hypertensive rats. METHODS: Male Wistar rats (200 - 250 g were allocated into Sedentary Normotensive (SN, Sedentary Hypertensive (SH and Trained Hypertensive (TH groups. Hypertension was induced by adding L-NAME (40 mg/Kg to the drinking water for four weeks. Arterial pressure was evaluated before and after RT. RT was performed using 50% of 1RM, 3 sets of 10 repetitions, 3 times per week for four weeks. Vascular reactivity was measured in rat mesenteric artery rings by concentration-response curves to sodium nitroprusside (SNP; phenylephrine (PHE was also used for histological and stereological analysis. RESULTS: Resistance training inhibited the increase in mean and diastolic arterial pressures. Significant reduction was observed in Rmax (maximal response and pD2 (potency of PHE between SH and TH groups. Arteries demonstrated normal intima, media and adventitia layers in all groups. Stereological analysis demonstrated no significant difference in luminal, tunica media, and total areas of arteries in the SH and TH groups when compared to the SN group. Wall-to-lumen ratio of SH arteries was significantly different compared to SN arteries (p<0.05 but there was no difference when compared to TH arteries. CONCLUSIONS: RT was able to prevent an increase in blood pressure under the conditions in this study. This appears to involve a vasoconstrictor regulation mechanism and maintenance of luminal diameter in L-NAME induced hypertensive rats.

Ayslan Jorge Santos de Araujo

2013-04-01

127

[Arterial pressure curve and fluid status].  

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Fluid optimization is a major contributor to improved outcome in patients. Unfortunately, anesthesiologists are often in doubt whether an additional fluid bolus will improve the hemodynamics of the patient or not as excess fluid may even jeopardize the condition. This article discusses physiological concepts of liberal versus restrictive fluid management followed by a discussion on the respective capabilities of various monitors to predict fluid responsiveness. The parameter difference in pulse pressure (dPP), derived from heart-lung interaction in mechanically ventilated patients is discussed in detail. The dPP cutoff value of 13% to predict fluid responsiveness is presented together with several assessment techniques of dPP. Finally, confounding variables on dPP measurements, such as ventilation parameters, pneumoperitoneum and use of norepinephrine are also mentioned. PMID:19326052

Pestel, G; Fukui, K

2009-04-01

128

Diastolic function in various forms of left ventricular hypertrophy: contribution of active Doppler stress echo.  

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It has been known for a long time that healthy athletes can develop left ventricular hypertrophy with typical electrocardiographic and echocardiographic findings which lead to the definition of the athlete's heart, as a separate physiological feature. In some cases it is difficult to distinguish between pathological versus physiological myocardial hypertrophy. Diastolic dysfunction is an early sign in the temporal sequence of ischemic events in coronary heart disease. Similar changes occur in other types of heart disease due to arterial hypertension or inflammation processes. Diastolic function is changed even in idiopathic hypertrophic cardiomyopathies. In contrast to these groups of patients, diastolic function remains unchanged or is improved in healthy athletes depending on the type of training (isotonic or isometric exercise). In cases with borderline changes, examinations during physical stress (exercise testing) which provokes an oxygen demand/supply imbalance and consecutively impairs early diastolic filling could clarify if an underlying heart disease is present. Although the physiology of diastolic function is complex, the factors contributing to diastolic disturbances can be differentiated into intrinsic and extrinsic left ventricular (LV) abnormalities. Intrinsic mechanisms include a) impaired LV relaxation, b) increased overall chamber stiffness, c) increased myocardial stiffness and d) increased LV asynchrony. All these factors are part of pathological LV hypertrophy. Factors extrinsic to the LV causing diastolic disorders include a) increased central blood volume, which will increase left ventricular pressure without altering the LV pressure-volume relation, and b) ventricular interaction mediated by pericardial restraint, which may cause a parallel upward shift of the diastolic LV pressure-volume curve. Improved understanding of LV relaxation and filling helps to differentiate pathological and physiological myocardial hypertrophy. Ongoing heart disease of different types can be diagnosed early by stress Doppler echocardiography in relation to other clinical findings and symptoms of the patient. PMID:9119541

Möckel, M; Störk, T

1996-11-01

129

Indicadores antropométricos e pressão arterial em escolares / Anthropometric measures and blood pressure in school children  

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Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese OBJETIVO: Investigar a relação entre pressão arterial e índice de massa corporal, circunferência abdominal, razão cintura/estatura e dobra cutânea tricipital em crianças e adolescentes. MÉTODOS: Estudo epidemiológico transversal, do qual participaram 1.441 escolares de 10 a 16 anos de idade (655 men [...] inos e 786 meninas), selecionados por amostragem aleatória sistemática. Avaliaram-se a massa corporal, a estatura, a circunferência abdominal, a espessura da dobra cutânea tricipital, as pressões arteriais - sistólica e diastólica - o estágio maturacional e a classe econômica. Utilizaram-se os testes de correlação parcial de Pearson e a regressão logística multivariada, considerando-se p Abstract in english OBJECTIVE: To investigate the association of blood pressure and body mass index, waist circumference, waist-to-height ratio and triceps skinfold, in children and adolescents in Curitiba, state of Paraná, Brazil. METHODS: Cross-sectional study with a random sample of 1,441 students from public school [...] s, aged from10 to 16 years (655 boys and 786 girls). The following indicators were assessed: weight, height, waist circumference, triceps skinfold, systolic and diastolic blood pressures, pubertal stage, and socioeconomic status. Pearson correlation tests and multivariate logistic regression were used, considering p

Deise Cristiane, Moser; Isabela de Carlos Back, Giuliano; Ana Cláudia Kapp, Titski; Anelise Reis, Gaya; Manuel João, Coelho-e-Silva; Neiva, Leite.

130

Effects of nifedipine on left ventricular systolic and diastolic functions in patients with left ventricular hypertrophy  

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The effect of nifedpine on left ventricular (LV) systolic and diastolic function was studied in 10 patients with hypertrophic cadiomyopathy(HCM), 8 patients with hypertensive hypertrophy(HT) and 9 normal subjects. Multigated cardiac blood pool imaging with Tc-99m were obtained at 40-degree left anterior oblique position before and after nifedipine administration (10 mg, sublingually). As systolic indices, we obtained LV ejection fraction and mean first third ejection rate. And as diastolic indices, mean filling rate during first third of diastole (1/3 FRsub(mean)) and diastolic maximal filling rate were calculated. Before nifedipine, systolic indices were significantly superior in HCM group than in other 2 groups, and diastolic indices were significantly lower in HCM and HT groups than in normal. After nifedipine, systolic indices improved in HT group but they did not change in other 2 groups. Diastolic indices improved significantly in HCM and HT groups after nifedpine. In HCM group, 1/3 FRsub(mean) improved more markedly in symptomatic patients than in asymptomatic patients. The ratio of diastolic function to systolic function (1/3 FRsub(mean)/1/3 ERsub(mean)) did not change in normal and HT groups but it increased significantly in HCM group. There we a slight increase in heart rate (HR) and decrease in systemic arterial pressure (BP). The increase in HR was similar among 3 groups but the decrease in BP was significantly greater in HT group in whom control BP was siater in HT group in whom control BP was significantly higher than other groups. LV end-diastolic volume did not change in 3 groups by nifedipine administration. These data suggested that abnormal diastolic function in HCM and HT was faborably modified by nifedipine, but their mechanisms were different. In HT, it was considered to relate with improved systolic function due to LV afterload reduction, while in HCM, it was not related to the peripheral hemodynamic effects nor improved systolic function. (author)

131

A Robust Approach towards Recognizing Valid Arterial Blood Pressure Pulses  

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We propose a projection method based on Singular Value Decomposition (SVD) to validate Arterial Blood Pressure (ABP) signal in order to avoid artifacts and noise in subsequent processing. The projection has been done on 567 validated ABP beats collected from 51 patients hospitalized in UCLA medical center. Then we compare the performance of the proposed projection method with that of a previously developed algorithm; Signal Abnormality Index (SAI); which is a value and trend based approach an...

Asgari, Shadnaz; Bergsneider, Marvin; Hu, Xiao

2010-01-01

132

Biochemical effects of lead exposure on systolic & diastolic blood pressure, heme biosynthesis and hematological parameters in automobile workers of north karnataka (India).  

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The purpose of this study was to find out the effect of lead exposure on systolic and diastolic blood pressure, heme biosynthesis related and hematological parameters of automobile workers. For this study 30 automobile workers were selected and compared with 30 age matched healthy control subjects. Significantly increased blood lead (364%, P ALAD) (-18.51%, P ALAD (-13.29%, P ALAD was significantly increased (43.83%, P < 0.001) in automobile workers as compared to controls. Excretions of ?-aminolevulinic acid (83.78%, P < 0.001) and porphobilinogen (37%, P < 0.001) in urine were significantly increased in the study group as compared to the controls. In automobile workers heamoglobin (-11.51%, P < 0.001), hematocrit (-4.06%, P < 0.05), mean corpuscle volume (-3.34%, P < 0.05), mean corpuscle hemoglobin (-5.66%, P < 0.01), mean corpuscle hemoglobin concentration (-7.67%, P < 0.001), red blood cell count (-14.6%, P < 0.001) were significantly decreased and total white blood cell count (11.44%, P < 0.05) increased as compared to the controls. The results of this study clearly indicate that the absorption of lead is more in automobile workers and it affects on blood pressure, heme biosynthesis and hematological parameters observed in this study group. PMID:23024478

Dongre, Nilima N; Suryakar, Adinath N; Patil, Arun J; Ambekar, Jeevan G; Rathi, Dileep B

2011-10-01

133

Effect of lisinopril and enalapril on quality of life and blood pressure daily profile in patients with stable arterial hypertension.  

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Full Text Available Aim. To compare effect of long-term treatment with lisinopril and enalapril on quality of life (QL and blood pressure (BP daily profile in patients with stable arterial hypertension (AH.Material and methods. Analysis of three studies conducted in our center during last 4 years are presented (totally 86 patients were included. Protocol of studies was unified: after wash-out period ambulatory blood pressure monitoring (ABPM and QL were assessed. Afterwards, patients were switched to active therapy with enalapril or lisinopril. After long-term treatment with these drugs QL and ABPM and QL were assessed again.Results. Both drugs decreased in systolic and diastolic BP, time index and didn't change heart rate and night BP dipping. With lisinopril treatment, significant improvement in physical condition, efficiency at work, psychological profile and capacity for social contacts was observed, while treatment with enalapril positively influenced only on physical condition and intensity of negative psychological profile in patients with stable AH.Conclusion. In patients with stable AH lisinopril had better influence on QL than enalapril. Therapy with both drugs lead to significant decrease in systolic and diastolic BP and didn't change heart rate and night BP dipping.

G.F. Andreeva

2006-01-01

134

Efectos del alcoholismo crónico sobre la presión arterial y frecuencia cardiaca en ratas adolescentes machos / Effects of chronic alcoholism on the arterial pressure and heart rate in male adolescent rats  

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Full Text Available SciELO Cuba | Language: Spanish Abstract in spanish Se caracterizaron los efectos que sobre la presión arterial y la frecuencia cardiaca ocasiona el alcoholismo crónico iniciado en la adolescencia en ratas albinas machos. Se confeccionaron 2 grupos de animales (experimental y control) y se hicieron 2 subgrupos de diferentes tiempos de tratamiento (3 [...] y 5 meses). A las ratas experimentales se les suministró etanol mediante cánula intraesofágica. Se estudió la presión arterial y la frecuencia cardiaca mediante plestimografía directa. Para el procesamiento estadístico de los resultados se utilizó ANOVA de 2 vías con interacción. La ingestión de etanol provocó un incremento en la presión arterial sistólica y diastólica tanto a los 3 como a los 5 meses de tratamiento. Este incremento fue mayor a los 5 meses de tratamiento. La frecuencia cardiaca no mostró cambios significativos. Se concluyó que la ingestión crónica de etanol eleva la presión arterial de forma tiempo dependiente. Abstract in english The effects of chronic alcoholism initiated in the adolescence on arterial pressure and heart rate were characterized in male albine rats. They were divided into 2 groups (experimental and control) and 2 subgroups with different times of treatment (3 and 5 months) were organized. The experimental ra [...] ts were administered ethanol by intraesophageal cannula. Arterial pressure and heart rate were studied by direct plethysmography. A two-way interactive ANOVA was used for the statistical processing of the results. The ingestion of ethanol produced an increase of the systolic and diastolic arterial pressure at 3 and 5 months of treatment. This rise was higher at 5 months of treatment. Heart rate did not show significant changes. It was concluded that the chronic ingestion of ethanol raises arterial pressure depending on time.

Aleida, Herrera Batista; Giselle, Puldón Seguí; Belsis, Díaz Rondón; Jorge, Bacallao Gallestey.

135

Effect of Rg3-enriched Korean red ginseng (Panax ginseng) on arterial stiffness and blood pressure in healthy individuals: a randomized controlled trial.  

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Ginsenoside Rg3, present in steamed ginseng (Panax Ginseng C.A. Meyer), is thought to be a potent modulator of vascular function. Our objective was to clinically evaluate acute effects of ginsenoside Rg3-enriched Korean red ginseng (Rg3-KRG) on measures of arterial stiffness and peripheral and central blood pressure (BP) parameters in healthy volunteers. Using a double-blind, randomized, crossover design, 23 individuals (9 males:14 females; age, 25 ± 2 years; body mass index, 22 ± 0.6 kg/m(2); systolic BP/diastolic BP, 113 ± 3/70 ± 2 mm Hg) were administered 400-mg Rg3-KRG extract or 400-mg wheat bran control on two separate visits with a 7-day washout period. Aortic augmentation index and central BP were measured using applanation tonometry by radial pulse wave analysis, and peripheral BP was evaluated oscillometrically. Measurements were taken at baseline and at 1, 2, and 3 hours after intervention. Compared with control, there were significant reductions in augmentation index (-4.3 ± 8.9%, P = .03), central (-4.8 ± 6.8 mm Hg, P = .01) and brachial mean arterial pressure (-4.4 ± 6.6 mm Hg, P = .01), central systolic (-5.0 ± 7.9 mm Hg, P = .01) and diastolic BP (-3.9 ± 6.6 mm Hg, P = .01), and brachial systolic (-4.4 ± 10.0 mm Hg, P = .048) and diastolic BP (-3.6 ± 6.4 mm Hg, P = .01) at 3 hours after intervention compared with control. This study is the first to demonstrate Rg3-KRG extract acutely lowers central and peripheral arterial pressures in healthy adults. Further clinical evaluation is desired to quantify efficacy in higher risk individuals and in long-term settings. PMID:24997863

Jovanovski, Elena; Bateman, Emma A; Bhardwaj, Jyoti; Fairgrieve, Chris; Mucalo, Iva; Jenkins, Alexandra L; Vuksan, Vladimir

2014-08-01

136

Augmentation of central arterial pressure in mild primary hyperparathyroidism.  

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Primary hyperparathyroidism (PHPT) is associated with increased cardiovascular risk, although the mechanisms involved remain unclear. Recent evidence has shown increased pulse pressure to be a powerful predictor of cardiovascular events. As increases in pulse pressure are due largely to arterial stiffening, we measured arterial stiffness in 21 subjects with PHPT (18 women and 3 men; 46-71 yr old) and 21 age- and sex-matched healthy controls using pulse wave analysis, a technique that measures peripheral arterial pressure waveforms and generates corresponding central aortic waveforms. This allows determination of the augmentation of central pressure resulting from wave reflection and augmentation index, a measure of vessel stiffness. Metabolic parameters were also measured. The serum calcium level among PHPT subjects was (mean +/- SD) 2.74+/-0.14 mmol/L. pulse wave analysis showed that both augmentation and the augmentation index were significantly higher in the PHPT group vs. controls [16+/-5 vs. 10+/-4 mm Hg (P < 0.001) and 36+/-9% vs. 25+/-6% (P < 0.001)] despite comparable brachial systolic pressures between groups (136+/-13 vs. 134+/-18 mm Hg). Patients with PHPT had higher fasting serum insulin levels [median (range), 15.8 (7.4-39.4) vs. 11.6 (5.1-23) mU/L; P < 0.05] and triglyceride (1.6+/-0.6 vs. 1.2+/-0.4 mmol/L; P < 0.05), but lower high density lipoprotein cholesterol (1.4+/-0.4 vs. 1.6+/-0.3 mmol/L; P < 0.05). These data indicate that subjects with mild PHPT (calcium, <3.0 mmol/L) have increased arterial stiffness, as evidenced by higher augmentation of central aortic pressures. Enhanced vessel stiffness may arise from a combination of structural and functional vascular changes due to hypercalcemia and/or metabolic abnormalities. Increased vascular stiffness in subjects with PHPT may account in part for the increased cardiovascular risk in this group. PMID:11061493

Smith, J C; Page, M D; John, R; Wheeler, M H; Cockcroft, J R; Scanlon, M F; Davies, J S

2000-10-01

137

Comportamiento de la presión pulmonar y función del ventrículo derecho intraesfuerzo / Pulmonary Artery Pressure and Right Ventricular Function during Exercise  

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Full Text Available SciELO Argentina | Language: Spanish Abstract in spanish Introducción El comportamiento fisiológico de la presión pulmonar durante el ejercicio continúa sin establecerse con precisión. La literatura es discordante con respecto a los valores considerados patológicos de presión pulmonar intraesfuerzo (PPI) en ausencia de valvulopatía mitral e incluso, las ú [...] ltimas guías no recomiendan utilizar la presión pulmonar media ? 30 mmHg con el esfuerzo para definir hipertensión pulmonar. Es escasa la información disponible en relación a la respuesta hemodinámica y funcional del ventrículo derecho (VD) con el esfuerzo y tampoco sobre el hecho de si podría discriminar entre una respuesta fisiológica o patológica de la presión pulmonar. Objetivo Determinar el comportamiento de la PPI y comparar los parámetros ecocardiográficos de función sistólica y diastólica del VD en relación a sus niveles. Material y Métodos Se incluyeron 94 pacientes sin cardiopatías significativas, con adecuada factibilidad para estimar presión pulmonar sistólica (PPS) basal y en máxima carga durate el eco-estrés en ejercicio. De acuerdo al valor de presión pulmonar con el ejercicio, la población fue estratificada en dos grupos: a) PI Abstract in english Background The physiological behavior of pulmonary artery pressure during exercise has not been precisely established yet. There is lack of agreement in the published literature about the abnormal values of pulmonary artery pressure (PAP) during exercise in the absence of mitral valve disease. Indee [...] d, the last guidelines do not recommend using mean pulmonary artery pressure value ? 30 mmHg during exercise to define pulmonary hypertension. There is scarce information about the hemodynamic and functional response of the right ventricle (RV) during exercise and if it is useful to discriminate between a physiological or abnormal response of the pulmonary artery pressure. Objectives To determine the behavior of PAP during exercise and to compare the echocardiographic parameters of systolic and diastolic RV function in relation to PAP levels. Material and Methods A total of 94 patients without significant heart disease were included. Systolic pulmonary artery pressure (SPAP) at rest and maximum exercise during dobutamine stress echocardiography was adequately measured in all patients. The population was divided into two groups according to the value of pulmonary artery pressure during exercise: a) PAP

Adrián J, Lescano; Roberto G, García Eleisequi; Carlos C, Canet; Martín J, Lombardero; Roberto O, Martingano.

2011-06-01

138

Monitorização ambulatorial da pressão arterial em pacientes normotensos com hipotireoidismo subclínico / Ambulatory blood pressure monitoring in normotensive patients with subclinical hypothyroidism  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese FUNDAMENTO: O hipotireoidismo manifesto está associado com elevação da pressão arterial diastólica; entretanto, a associação entre o hipotireoidismo subclínico (HS) e alteração da pressão arterial (PA) é desconhecida. OBJETIVO: O objetivo do presente estudo foi avaliar a monitorização ambulatorial d [...] a pressão arterial (MAPA) por 24 horas em pacientes normotensos com HS em comparação a indivíduos normotensos eutireóideos (EU). MÉTODOS: Foi realizado um estudo transversal com 50 participantes (HS = 30 e EU = 20) que não apresentavam diferenças em relação a fatores de risco para hipertensão. A monitorização ambulatorial de pressão arterial foi realizada com um monitor Dynamapa®, utilizando-se um método oscilométrico validado pela AAMI (Association for the Advancement of Medical Instrumentation) e pela BHS (British Hypertension Society). RESULTADOS: Os níveis séricos médios de TSH e T4 livre foram respectivamente 6,9 ± 2,2 µUI/ml e 1,1 ± 0,2 ng/dl em pacientes com HS. Apesar de não haver diferença em relação à média da pressão arterial sistólica e diastólica entre os dois grupos, houve uma correlação positiva entre os níveis de pressão arterial diastólica média (PADM) e os valores séricos de TSH em pacientes com HS (r:0,477; p = 0,004). Essa correlação foi detectada por medidas diurnas (r:0,498; p = 0,002) e noturnas (r:0,322; p = 0,032). CONCLUSÃO: A pressão arterial não diferiu entre pacientes com ou sem HS; contudo, os resultados sugerem que a progressão de hipotireoidismo subclínico para níveis mais elevados de TSH pode aumentar o risco cardiovascular através do aumento da pressão arterial diastólica. Abstract in english BACKGROUND: Overt hypothyroidism is associated with elevation of diastolic blood pressure; however the association of subclinical hypothyroidism (SH) with arterial blood pressure (ABP) alteration is unknown. OBJECTIVE: The aim of the present study was to evaluate ambulatory blood pressure monitoring [...] (ABPM), over 24 hours, in normotensive patients with SH in comparison to euthyroid (EU) normotensive individuals. METHODS: A cross-sectional study was performed with 50 participants (SH = 30 and EU = 20) that did not differ regarding risk factors for hypertension. The ABPM was carried out with a DINAMAPA TM monitor, using the oscillometric method validated by AAMI (Association for the Advancement of Medical Instrumentation) and by the BHS (British Hypertension Society). RESULTS: The mean serum TSH and FT4 were respectively 6.9 ± 2.2 µUI/ml and 1.1 ± 0.2 ng/dl in SH patients. Although there was no difference in the mean values of systolic and diastolic blood pressure between the two groups, there was a positive correlation between the mean values of diastolic blood pressure (DBP) and serum TSH levels in SH patients (r:0.477; p = 0.004). These correlations were detected at daytime (r:0.498; p = 0.002) and sleep-time (r:0.322; p = 0.032) measurements. CONCLUSION: The blood pressure was not different between patients with or without SH; however, the results suggest that the progression of subclinical hypothyroidism to higher levels of TSH may increase the cardiovascular risk by increasing diastolic blood pressure.

Marcia Martins, Ferreira; Patricia de Fatima dos Santos, Teixeira; Vera Aleta R., Mansur; Vaneska Spinelli, Reuters; Cloyra Paiva, Almeida; Mario, Vaisman.

139

Monitorização ambulatorial da pressão arterial em pacientes normotensos com hipotireoidismo subclínico Ambulatory blood pressure monitoring in normotensive patients with subclinical hypothyroidism  

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Full Text Available FUNDAMENTO: O hipotireoidismo manifesto está associado com elevação da pressão arterial diastólica; entretanto, a associação entre o hipotireoidismo subclínico (HS e alteração da pressão arterial (PA é desconhecida. OBJETIVO: O objetivo do presente estudo foi avaliar a monitorização ambulatorial da pressão arterial (MAPA por 24 horas em pacientes normotensos com HS em comparação a indivíduos normotensos eutireóideos (EU. MÉTODOS: Foi realizado um estudo transversal com 50 participantes (HS = 30 e EU = 20 que não apresentavam diferenças em relação a fatores de risco para hipertensão. A monitorização ambulatorial de pressão arterial foi realizada com um monitor Dynamapa®, utilizando-se um método oscilométrico validado pela AAMI (Association for the Advancement of Medical Instrumentation e pela BHS (British Hypertension Society. RESULTADOS: Os níveis séricos médios de TSH e T4 livre foram respectivamente 6,9 ± 2,2 µUI/ml e 1,1 ± 0,2 ng/dl em pacientes com HS. Apesar de não haver diferença em relação à média da pressão arterial sistólica e diastólica entre os dois grupos, houve uma correlação positiva entre os níveis de pressão arterial diastólica média (PADM e os valores séricos de TSH em pacientes com HS (r:0,477; p = 0,004. Essa correlação foi detectada por medidas diurnas (r:0,498; p = 0,002 e noturnas (r:0,322; p = 0,032. CONCLUSÃO: A pressão arterial não diferiu entre pacientes com ou sem HS; contudo, os resultados sugerem que a progressão de hipotireoidismo subclínico para níveis mais elevados de TSH pode aumentar o risco cardiovascular através do aumento da pressão arterial diastólica.BACKGROUND: Overt hypothyroidism is associated with elevation of diastolic blood pressure; however the association of subclinical hypothyroidism (SH with arterial blood pressure (ABP alteration is unknown. OBJECTIVE: The aim of the present study was to evaluate ambulatory blood pressure monitoring (ABPM, over 24 hours, in normotensive patients with SH in comparison to euthyroid (EU normotensive individuals. METHODS: A cross-sectional study was performed with 50 participants (SH = 30 and EU = 20 that did not differ regarding risk factors for hypertension. The ABPM was carried out with a DINAMAPA TM monitor, using the oscillometric method validated by AAMI (Association for the Advancement of Medical Instrumentation and by the BHS (British Hypertension Society. RESULTS: The mean serum TSH and FT4 were respectively 6.9 ± 2.2 µUI/ml and 1.1 ± 0.2 ng/dl in SH patients. Although there was no difference in the mean values of systolic and diastolic blood pressure between the two groups, there was a positive correlation between the mean values of diastolic blood pressure (DBP and serum TSH levels in SH patients (r:0.477; p = 0.004. These correlations were detected at daytime (r:0.498; p = 0.002 and sleep-time (r:0.322; p = 0.032 measurements. CONCLUSION: The blood pressure was not different between patients with or without SH; however, the results suggest that the progression of subclinical hypothyroidism to higher levels of TSH may increase the cardiovascular risk by increasing diastolic blood pressure.

Marcia Martins Ferreira

2010-06-01

140

Efficacy of a classical antiobesity Unani pharmacopial formulation (Safoof-e-Muhazzil) in systolic and diastolic blood pressure: A randomized, open-labeled, controlled clinical study.  

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The aim of this study is to evaluate the efficacy of a Unani formulation in hypertension. A total of 90 patients with total cholesterol level of more than 220 mg/dl with associated conditions were included in this study. A total of 30 patients having a mean systolic blood pressure (BP) of 133.86 mmHg comprising Group A received Unani formulation Safoof-e-Muhazzil (SM) in its classical powder form in the dose of 5 g twice a day orally. Group B comprising of 30 patients with a mean systolic BP of 133.13 mmHg received same drug, but in compressed tablet form in the same dosage, whereas, 30 patients comprising Group C with a mean systolic BP of 129.45 mmHg, received Atorvastatin 10 mg as a standard control. Patients were evaluated on each follow-up at 2(nd), 4(th) and 6(th) week. The mean systolic BP in Group A and B before treatment was 133.86 ± 3.028 mmHg and 133.13 ± 2.852 mmHg, which significantly decreased to 119.33 ± 1.922 mmHg (P < 0.001) and 119 ± 1.760 mmHg (P < 0.001) respectively. In the control Group C before treatment BP was 129.45 ± 2.499 mmHg and after treatment it significantly decreased to 124.34 ± 1.794 mmHg (P < 0.01). The percentage change after treatment was 10.85%, 10.61% and 3.94% respectively in each group. Mean diastolic BP in Group A and B before treatment was 85.06 ± 2.11 mmHg and 84.56 ± 1.5 mmHg, which significantly decreased to 79.06 ± 1.56 mmHg (P < 0.001) and 79.96 ± 1.15 mmHg (P < 0.001) respectively, BP before treatment in Group C was 83.23 ± 1.588 mmHg, which was decreased to 124.34 ± 1.794 mmHg (P < 0.01). The study results indicate that the test drug was quite effective in reducing both systolic as well as diastolic BP. PMID:24350049

Khan, Asim Ali; Jahangir, Umar; Jalees, Farhan; Kapoor, Prem; Urooj, Shaista

2013-10-01

 
 
 
 
141

Right ventricular diastolic dysfunction and patent foramen ovale causing profound cyanosis  

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A 73 year old woman presented with profound central cyanosis and a history of a minor stroke. She had normal heart morphology, normal pulmonary artery pressure, and a normal coronary angiography. A patent foramen ovale (PFO) with a massive right to left shunt was demonstrated at the atrial level, with normal pulmonary venous saturations and Po2 values. This rare, age related case of right ventricular diastolic dysfunction in a normotensive patient revealed a generous PFO allowing a pronounced...

Shnaider, H.; Shiran, A.; Lorber, A.

2004-01-01

142

Pressão arterial de adolescentes de escolas particulares de Fortaleza-CE Presión arterial de adolescentes de escuelas particulares en Fortaleza-CE Blood pressure of adolescents in private schools in Fortaleza-CE  

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Full Text Available OBJETIVO: Identificar a pressão arterial de adolescentes de escolas particulares da cidade de Fortaleza-CE. MÉTODOS: Estudo do tipo quantitativo com delineamento transversal no qual foram investigados 794 adolescentes, entre 12-17 anos de idade de 14 escolas privadas dessa cidade no período de março a setembro de 2007, mediante aplicação de um formulário que abrangeu o registro das características sóciodemográficas, pressão arterial, Índice de Massa Corporal (IMC, prática de atividade física e glicemia capilar. RESULTADOS: Verificou-se que 19,7% dos jovens apresentavam pressão arterial elevada. Os adolescentes do sexo masculino apresentaram pressão arteial sistólica (PAS e pressão arterial diastólica (PAD maiores do que a do sexo feminino (p=0,0001. A pesquisa constatou valores maiores de PAS e PAD naqueles com excesso de peso (p=0,0001. CONCLUSÃO: A pressão arterial foi influenciada sobretudo pelo sexo e IMC.OBJETIVO: Identificar la presión arterial de adolescentes de escuelas particulares en la ciudad de Fortaleza-CE. MÉTODOS: Se trata de un estudio cuantitativo con delineamiento transversal en el cual fueron investigados 794 adolescentes - entre 12 y 17 años de edad - de 14 escuelas privadas de esa ciudad, en el período de marzo a septiembre de 2007. Se utilizó un formulario que contempló el registro de las siguientes características: socio-demográficas, presión arterial, Índice de Masa Corporal (IMC, práctica de actividad física y, glucemia capilar. RESULTADOS: Se verificó que 19,7% de los jóvenes presentaban presión arterial elevada. Los adolescentes del sexo masculino presentaron presión arterial sistólica (PAS y presión arterial diastólica (PAD mayores que las del sexo femenino (p=0,0001. La investigación constató valores mayores de PAS y PAD en aquellos con exceso de peso (p=0,0001. CONCLUSIÓN: La presión arterial fue influenciada, sobre todo, por el sexo y el IMC.OBJECTIVE: To identify the blood pressure of adolescents in private schools in the city of Fortaleza-CE. METHODS: This is a cross-sectional and quantitative study in which 794 adolescents were surveyed - between 12 and 17 years of age - from 14 private schools of that city, in the period from March to September 2007. It was used a questionnaire that contemplated the following characteristics: socio-demographic, blood pressure, body mass index (BMI, physical activity and capillary glucose. RESULTS: It was found that 19.7% of young people had high blood pressure. The male participants had systolic blood pressure (SBP and diastolic blood pressure (DBP higher than females (p=0.0001. The investigation found higher values of SBP and DBP in those who were overweight (p=0.0001. CONCLUSION: The blood pressure was influenced mainly by gender and BMI.

Polyana Carina Viana da Silva

2010-01-01

143

Increased systemic blood pressure and arterial stiffness in young adults born prematurely.  

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Recent studies have shown that a low birth weight is a risk factor for increased systemic blood pressure (BP) in adulthood. Further, systemic BP and arterial stiffness (AS) are reported to be increased in adolescents born prematurely. The purpose of this study was to characterize systemic BP and AS in young adults born preterm. Systemic BP was measured using an automated oscillometric device. AS was assessed by measuring the right carotid-radial pulse wave velocity (PWV) using a validated non-invasive automated method. Systemic BP, pulse pressure, and PWV [mean (confidence intervals)] were compared between 16 adults (age 21 years) born preterm (age at birth 32 weeks of gestation) with a birth weight (1710 g) appropriate for their gestational age and 15 adults (21 years) born at term (40 weeks of gestation) with a birth weight (3430 g) appropriate for their gestational age. Adults born preterm had a significantly higher systolic BP [122 mmHg (114-144) v. 112 (106-127)], mean BP [89 mmHg (86-98) v. 84 (81-91)], diastolic BP [69 mmHg (66-76) v. 65 (62-78)], pulse pressure [54 mmHg (47-72) v. 47 (42-60)], and PWV [7 m/s (6.3-8.6) v. 6.4 (5.8-8)] than did those born at term. Our findings suggest that young adults with a low birth weight due to preterm birth have increased systemic BP and AS. Accordingly, preterm birth may predispose individuals to cardiovascular diseases in adulthood due to increased AS. PMID:25154472

Tauzin, L; Rossi, P; Grosse, C; Boussuges, A; Frances, Y; Tsimaratos, M; Simeoni, U

2014-12-01

144

Machine Learning Techniques for Arterial Pressure Waveform Analysis  

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Full Text Available The Arterial Pressure Waveform (APW can provide essential information about arterial wall integrity and arterial stiffness. Most of APW analysis frameworks individually process each hemodynamic parameter and do not evaluate inter-dependencies in the overall pulse morphology. The key contribution of this work is the use of machine learning algorithms to deal with vectorized features extracted from APW. With this purpose, we follow a five-step evaluation methodology: (1 a custom-designed, non-invasive, electromechanical device was used in the data collection from 50 subjects; (2 the acquired position and amplitude of onset, Systolic Peak (SP, Point of Inflection (Pi and Dicrotic Wave (DW were used for the computation of some morphological attributes; (3 pre-processing work on the datasets was performed in order to reduce the number of input features and increase the model accuracy by selecting the most relevant ones; (4 classification of the dataset was carried out using four different machine learning algorithms: Random Forest, BayesNet (probabilistic, J48 (decision tree and RIPPER (rule-based induction; and (5 we evaluate the trained models, using the majority-voting system, comparatively to the respective calculated Augmentation Index (AIx. Classification algorithms have been proved to be efficient, in particular Random Forest has shown good accuracy (96.95% and high area under the curve (AUC of a Receiver Operating Characteristic (ROC curve (0.961. Finally, during validation tests, a correlation between high risk labels, retrieved from the multi-parametric approach, and positive AIx values was verified. This approach gives allowance for designing new hemodynamic morphology vectors and techniques for multiple APW analysis, thus improving the arterial pulse understanding, especially when compared to traditional single-parameter analysis, where the failure in one parameter measurement component, such as Pi, can jeopardize the whole evaluation.

João Cardoso

2013-05-01

145

A new method for estimating arterial occlusion pressure in optimizing pneumatic tourniquet inflation pressure.  

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To reduce pressure-related injuries resulting from pneumatic tourniquet use, the lowest possible inflation pressure is recommended. Arterial occlusion pressure (AOP) is a measure of the cuff pressure required to maintain a bloodless surgical field. However, its determination method is time consuming, requires operator skill, and is therefore seldom used in current practice. An AOP estimation can be made by knowing the pressure transmitted to the underlying soft tissues. We measured upper and lower extremity tissue pressures under the tourniquet cuff at 100, 200, and 300 mm Hg of tourniquet inflation pressures in 30 anesthetized living adult patients. All patients received general anesthesia with neuromuscular relaxation. A Stryker intra-compartmental pressure monitor was used to measure tissue pressures under the tourniquet cuff. In all patients, the soft tissue pressures were consistently lower than the applied tourniquet inflation pressures. Our results revealed tissue padding coefficients for extremities 20 to 75 cm in circumferences. An estimation method of AOP was developed [AOP = (systolic blood pressure + 10)/Tissue padding coefficient]. The new AOP estimation method may be a simple, rapid, and clinically practical alternative to the AOP determination method. PMID:16717321

Tuncali, Bahattin; Karci, Ayse; Tuncali, Binnur Erdalkiran; Mavioglu, Omur; Ozkan, Mustafa; Bacakoglu, Abdul Kadir; Baydur, Hakan; Ekin, Ahmet; Elar, Zahide

2006-06-01

146

Efeito do treinamento com pesos na pressão arterial de repouso em idosas normotensas / Effect of resistence training in blood pressure at rest in normotensive elderly  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese INTRODUÇÃO: O treinamento com pesos (TP) tem sido amplamente empregado em adultos idosos com objetivo de minimizar ou reverter os efeitos deletérios do processo de envelhecimento no sistema neuromuscular. No entanto, os potenciais benefícios do TP para a pressão arterial e frequência cardíaca de rep [...] ouso de adultos idosos ainda permanecem controversos. OBJETIVO: Analisar o efeito de oito semanas de TP na pressão arterial sistólica (PAS), pressão arterial diastólica (PAD), pressão arterial média (PAM) e frequência cardíaca (FC) de repouso em idosas sem hipertensão arterial. MÉTODOS: Dezessete mulheres idosas (66,0 ± 5,8 anos) sem experiência em TP foram separadas aleatoriamente em grupo treinamento (GT; n = 10) e grupo controle (GC; n = 7). As variáveis hemodinâmicas de repouso foram avaliadas pelo método auscultatório (esfigmomanômetro de mercúrio) e frequencímetro cardíaco (Polar), antes e após oito semanas do período experimental. RESULTADOS: Reduções atribuíveis ao TP foram encontradas apenas para a PAS (-13,4 mmHg; p Abstract in english INTRODUCTION: Resistance training (RT) has been widely used for older adults in order to minimize or reverse the deleterious effects of aging in the neuromuscular system. However, the potential benefits of RT on arterial blood pressure and heart rate at rest in older adults remain controversial. OBJ [...] ECTIVE: To analyze the effect of eight weeks of RT on systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP) and heart rate (HR) in older women without hypertension. METHODS: Seventeen women (aged 66.0 ± 5.8 years) without previous experience in RT were randomly assigned to either a training (TG, n = 10) or control (CG, n = 7) groups. Hemodynamic parameters at rest were evaluated by auscultatory method (mercury sphygmomanometer) and HR monitor (Polar), before and after eight weeks of experimental period. RESULTS: Reductions attributable to RT were found only to SBP (-13.4 mmHg, p

André Luiz Demantova, Gurjão; Raquel, Gonçalves; Nelson Hilário, Carneiro; Marilia, Ceccato; José Claudio, Jambassi Filho; Sebastião, Gobbi.

147

Efeito do treinamento com pesos na pressão arterial de repouso em idosas normotensas / Effect of resistence training in blood pressure at rest in normotensive elderly  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese INTRODUÇÃO: O treinamento com pesos (TP) tem sido amplamente empregado em adultos idosos com objetivo de minimizar ou reverter os efeitos deletérios do processo de envelhecimento no sistema neuromuscular. No entanto, os potenciais benefícios do TP para a pressão arterial e frequência cardíaca de rep [...] ouso de adultos idosos ainda permanecem controversos. OBJETIVO: Analisar o efeito de oito semanas de TP na pressão arterial sistólica (PAS), pressão arterial diastólica (PAD), pressão arterial média (PAM) e frequência cardíaca (FC) de repouso em idosas sem hipertensão arterial. MÉTODOS: Dezessete mulheres idosas (66,0 ± 5,8 anos) sem experiência em TP foram separadas aleatoriamente em grupo treinamento (GT; n = 10) e grupo controle (GC; n = 7). As variáveis hemodinâmicas de repouso foram avaliadas pelo método auscultatório (esfigmomanômetro de mercúrio) e frequencímetro cardíaco (Polar), antes e após oito semanas do período experimental. RESULTADOS: Reduções atribuíveis ao TP foram encontradas apenas para a PAS (-13,4 mmHg; p Abstract in english INTRODUCTION: Resistance training (RT) has been widely used for older adults in order to minimize or reverse the deleterious effects of aging in the neuromuscular system. However, the potential benefits of RT on arterial blood pressure and heart rate at rest in older adults remain controversial. OBJ [...] ECTIVE: To analyze the effect of eight weeks of RT on systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP) and heart rate (HR) in older women without hypertension. METHODS: Seventeen women (aged 66.0 ± 5.8 years) without previous experience in RT were randomly assigned to either a training (TG, n = 10) or control (CG, n = 7) groups. Hemodynamic parameters at rest were evaluated by auscultatory method (mercury sphygmomanometer) and HR monitor (Polar), before and after eight weeks of experimental period. RESULTS: Reductions attributable to RT were found only to SBP (-13.4 mmHg, p

André Luiz Demantova, Gurjão; Raquel, Gonçalves; Nelson Hilário, Carneiro; Marilia, Ceccato; José Claudio, Jambassi Filho; Sebastião, Gobbi.

2013-06-01

148

Measurement of pulmonary artery pressure by doppler and comparison with catheterization method  

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Full Text Available Pulmonary artery pressure can be estimated from right ventricular-right atrial pressure gradient in patients with tricuspid regurgitation. The most common approach is to estimate pulmonary artery systolic pressure from right ventricular pressure (assuming no pulmonic stenosis determined as the sum of the right ventricular-right atrial pressure gradient and either an assumed or clinically determined right atrial pressure. But in this study, that was done on 62 patients in 1996 in Imam Khomeini hospital, we demonstrated that it was not needed to add an assumed right atrial pressure to right ventricular-right atrial pressure gradient. We also demonstrated that pulmonary artery pressure estimated in this study, bears a direct relationship to systolic pulmonary artery pressure derived in right heart catheterization (r=0.98, standard error of estimulation

Ranjbarnejad Esfahani H

1998-06-01

149

Avaliação comparativa entre a anestesia geral com halotano e isoflurano sobre a pressão arterial em cães / Comparartive evaluation of the general anesthesia with halothane and isoflurane on the arterial pressure in dogs  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese As alterações produzidas pelo halotano e isoflurano sobre as pressões arteriais sistólica, diastólica e média foram avaliadas em 34 caninos de ambos os sexos e de diferentes pesos corporais e raças, todos submetidos a procedimentos cirúrgicos ortopédicos, divididos em dois grupos de 17 animais, subm [...] etidos a jejum prévio de 12 horas antes da indução anestésica. Os animais de ambos os grupos receberam sulfato de atropina 0,04mg/kg, associado ao sulfato de morfina 1,5mg/kg, administrados por via intramuscular e indução anestésica com propofol 6mg/kg por via intravenosa e a anestesia geral foi mantida com halotano no grupo I e o isoflurano no grupo II. Em ambos os grupos, o óxido nitroso na proporção 2:1 com oxigênio foi utilizado como gás diluente do anestésico volátil. Decorridos 15 minutos do início da anestesia volátil, as pressões sistólica, diastólica e média foram mensuradas pelo método oscilométrico indireto até o período de 90 minutos. Observou-se que as pressões arteriais sistólica e diastólica do grupo II foi maior a partir dos 45 minutos de manutenção com os anestésicos voláteis, não ocorrendo diferença significativa na freqüência cardíaca. Conclui-se que a manutenção anestésica com isoflurano produz valores de pressão arterial sistólica e diastólica superiores à manutenção com halotano que causou hipotensão arterial dos 45 aos 75 minutos de anestesia volátil. Abstract in english Changes in arterial systolic, diastolic, and mean blood pressure were evaluated and compared in 34 dogs anesthetized with halothane or isoflurane and submitted to orthopedic surgeries. Two groups were formed each with 17 dogs. These animals were fasted for 12 hours before anesthesia induction. Anest [...] hetic technique was premedication with 0.04mg/kg atropine intramuscular combined 1.5mg/kg morphine intramuscular. Anesthesia was induced with 6.0mg/kg propofol intravenously. Anesthesia was maintained with halothane in group I and isoflurane in group II. In both groups, nitrous oxide and oxygen in a 2:1 ratio was used as diluent for the inhalant. After 15 minutes of inhalation anesthesia, arterial blood pressures were recorded with a noninvasive blood pressure monitor in 15 minutes intervals for 90 minutes. Statistical analyses showed that there was a significant difference in systolic and diastolic pressures after 45 minutes. Differences in heart rate were not significant. In dos, general anesthesia with isoflurane maintained higher arterial blood pressures than those anesthetized with halothane which produced arterial hipotension from 45 to 75 minutes of anesthesia.

Cláudio Corrêa, Natalini; Jefferson da Silva, Pires.

2000-06-01

150

Avaliação comparativa entre a anestesia geral com halotano e isoflurano sobre a pressão arterial em cães Comparartive evaluation of the general anesthesia with halothane and isoflurane on the arterial pressure in dogs  

Directory of Open Access Journals (Sweden)

Full Text Available As alterações produzidas pelo halotano e isoflurano sobre as pressões arteriais sistólica, diastólica e média foram avaliadas em 34 caninos de ambos os sexos e de diferentes pesos corporais e raças, todos submetidos a procedimentos cirúrgicos ortopédicos, divididos em dois grupos de 17 animais, submetidos a jejum prévio de 12 horas antes da indução anestésica. Os animais de ambos os grupos receberam sulfato de atropina 0,04mg/kg, associado ao sulfato de morfina 1,5mg/kg, administrados por via intramuscular e indução anestésica com propofol 6mg/kg por via intravenosa e a anestesia geral foi mantida com halotano no grupo I e o isoflurano no grupo II. Em ambos os grupos, o óxido nitroso na proporção 2:1 com oxigênio foi utilizado como gás diluente do anestésico volátil. Decorridos 15 minutos do início da anestesia volátil, as pressões sistólica, diastólica e média foram mensuradas pelo método oscilométrico indireto até o período de 90 minutos. Observou-se que as pressões arteriais sistólica e diastólica do grupo II foi maior a partir dos 45 minutos de manutenção com os anestésicos voláteis, não ocorrendo diferença significativa na freqüência cardíaca. Conclui-se que a manutenção anestésica com isoflurano produz valores de pressão arterial sistólica e diastólica superiores à manutenção com halotano que causou hipotensão arterial dos 45 aos 75 minutos de anestesia volátil.Changes in arterial systolic, diastolic, and mean blood pressure were evaluated and compared in 34 dogs anesthetized with halothane or isoflurane and submitted to orthopedic surgeries. Two groups were formed each with 17 dogs. These animals were fasted for 12 hours before anesthesia induction. Anesthetic technique was premedication with 0.04mg/kg atropine intramuscular combined 1.5mg/kg morphine intramuscular. Anesthesia was induced with 6.0mg/kg propofol intravenously. Anesthesia was maintained with halothane in group I and isoflurane in group II. In both groups, nitrous oxide and oxygen in a 2:1 ratio was used as diluent for the inhalant. After 15 minutes of inhalation anesthesia, arterial blood pressures were recorded with a noninvasive blood pressure monitor in 15 minutes intervals for 90 minutes. Statistical analyses showed that there was a significant difference in systolic and diastolic pressures after 45 minutes. Differences in heart rate were not significant. In dos, general anesthesia with isoflurane maintained higher arterial blood pressures than those anesthetized with halothane which produced arterial hipotension from 45 to 75 minutes of anesthesia.

Cláudio Corrêa Natalini

2000-06-01

151

Comparison of pulse oximeters: accuracy at low arterial pressure in volunteers.  

Science.gov (United States)

A laboratory model was developed of limb hypoperfusion in volunteers, using parital occlusion of the brachial artery with consequent reduction in radial artery pulse pressure. This was used to compare the function of 13 pulse oximeters and the effect of reduced pulse pressure and mild hypoxia on these devices. With the exception of one device, all the pulse oximeters studied demonstrated similar accuracies at pulse pressures exceeding 20 mm Hg. There were however, significant differences between several of the pulse oximeters in both ability to display readings and accuracy of readings displayed when brachial artery occlusion reduced radial artery pulse pressures equal to or less than 20 mm Hg. PMID:2248826

Falconer, R J; Robinson, B J

1990-10-01

152

Avaliação de fatores de risco associados com elevação da pressão arterial em crianças / Evaluation of risk factors associated with increased blood pressure in children  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese OBJETIVOS: Identificar fatores associados a níveis elevados de pressão arterial em crianças. MÉTODOS: Estudo transversal da pressão arterial de 672 crianças entre 2 e 11 anos de idade em duas instituições de ensino de Belo Horizonte, entre setembro e dezembro de 2001. A pressão arterial foi mensurad [...] a seguindo os parâmetros estabelecidos pelo relatório do Update on the 1987 Task Force Report on High Blood Pressure in Children and Adolescents. As seguintes variáveis foram estudadas: idade, sexo, cor da pele, índice de qualidade de vida urbana, estatura e índice de massa corporal. Para a comparação das médias, foi utilizada a análise de variância, e para a comparação de proporções, o teste qui-quadrado. As variáveis associadas a níveis mais elevados de pressão arterial foram incluídas em análise de regressão linear múltipla. RESULTADOS: Na análise univariada, níveis mais elevados de pressão arterial sistólica e diastólica estiveram associados com crianças de cor branca, crianças da região com alto índice de qualidade de vida urbana e com elevado índice de massa corporal. Na análise multivariada, apenas o índice de massa corporal, o índice de qualidade de vida urbana e a estatura mantiveram-se associados com níveis elevados de pressão sistólica. Em relação aos níveis mais elevados de pressão arterial diastólica, apenas as variáveis índice de qualidade de vida urbana e idade foram mantidas no modelo após o ajustamento. CONCLUSÃO: O sobrepeso e a obesidade estiveram associados com níveis mais elevados de pressão arterial sistólica. Outros fatores, não identificados, foram parcialmente associados a níveis mais elevados de pressão arterial de crianças do estabelecimento privado do ensino. Abstract in english OBJECTIVE: To identify factors associated with increased arterial blood pressure in children. METHODS: In this cross-sectional study, arterial blood pressure was measured in 672 children between 2 and 11 years of age from two schools in the city of Belo Horizonte, Brazil. After providing informed co [...] nsent, all children had their blood pressure and anthropometric parameters measured. Blood pressure was measured based on the recommendations of the Update on the 1987 Task Force Report on High Blood Pressure in Children and Adolescents. The following variables were assessed: age, sex, race, urban life quality index, weight, height, and body mass index. Analysis of variance was used for comparison of means and the chi-square was used for comparison of proportions. Variables associated with increased blood pressure were included in a multiple regression model. RESULTS: According to univariate analysis, increased systolic and diastolic blood pressure were associated with high urban life quality index, white race and high body mass index. On multivariate analysis, body mass index, urban life quality index and height remained associated with increased systolic blood pressure; urban life quality index and age were associated with increased diastolic blood pressure. CONCLUSION: In this study, excess weight and obesity were associated with increased systolic blood pressure. Other unidentified factors were partially associated with increased blood pressure in children from the school with elevated urban life quality index.

Frederico D, Garcia; Aleyson F, Terra; Anderson M, Queiroz; Cristiano A, Correia; Priscila S, Ramos; Quésia T, Ferreira; Regina L, Rocha; Eduardo A, Oliveira.

153

Avaliação de fatores de risco associados com elevação da pressão arterial em crianças / Evaluation of risk factors associated with increased blood pressure in children  

Scientific Electronic Library Online (English)

Full Text Available SciELO Chile | Language: Portuguese Abstract in portuguese Objetivos: Identificar fatores associados a níveis elevados de pressão arterial em crianças. Métodos: Estudo transversal da pressão arterial de 672 crianças entre 2 e 11 anos de idade em duas instituições de ensino de Belo Horizonte, entre setembro e dezembro de 2001. A pressão arterial foi mensurad [...] a seguindo os parámetros estabelecidos pelo relatório do Update on the 1987 Task Force Report on High Blood Pressure in Children and Adolescents. As seguintes variáveis foram estudadas: idade, sexo, cor da pele, índice de qualidade de vida urbana, estatura e índice de massa corporal. Para a comparação das médias, foi utilizada a análise de variãncia, e para a comparação de proporções, o teste quiquadrado. As variãveis associadas a níveis mais elevados de pressão arterial foram incluídas em análise de regressão linear múltipla. Resultados: Na análise univariada, níveis mais elevados de pressão arterial sistólica e diastólica estiveram associados com crianças de cor branca, crianças da região com alto índice de qualidade de vida urbana e com elevado índice de massa corporal. Na análise multivariada, apenas o índice de massa corporal, o índice de qualidade de vida urbana e a estatura mantiveram-se associados com níveis elevados de pressão sistólica. Em relação aos níveis mais elevados de pressão arterial diastólica, apenas as variáveis índice de qualidade de vida urbana e idade foram mantidas no modelo após o ajustamento. Conclusão: O sobrepeso e a obesidade estiveram associados com níveis mais elevados de pressão arterial sistólica. Outros fatores, não identificados, foram parcialmente associados a níveis mais elevados de pressão arterial de crianças do estabelecimento privado do ensino Abstract in english To identify factors associated with increased arterial blood pressure in children. Methods: In this cross-sectional study, arterial blood pressure was measured in 672 children between 2 and 11 years of age from two schools in the city of Belo Horizonte, Brazil. After providing informed consent, all [...] children had their blood pressure and anthropometric parameters measured. Blood pressure was measured based on the recommendations of the Update on the 1987 Task Force Report on High Blood Pressure in Children and Adolescents. The following variables were assessed: age, sex, race, urban life quality index, weight, height, and body mass index. Analysis of variance was used for comparison of means and the chi-square was used for comparison of proportions. Variables associated with increased blood pressure were included in a multiple regression model. Results: According to univariate analysis, increased systolic and diastolic blood pressure were associated with high urban life quality index, white race and high body mass index. On multivariate analysis, body mass index, urban life quality index and height remained associated with increased systolic blood pressure; urban life quality index and age were associated with increased diastolic blood pressure. Conclusion: In this study, excess weight and obesity were associated with increased systolic blood pressure. Other unidentified factors were partially associated with increased blood pressure in children from the school with elevated urban life quality index

Frederico D, Garcia; Aleyson F, Terra; Anderson M, Queiroz; Cristiano A, Correia; Priscila S, Ramos; Quèsia T, Ferreira; Regina L, Rocha; Eduardo A, Oliveira.

154

Avaliação de fatores de risco associados com elevação da pressão arterial em crianças Evaluation of risk factors associated with increased blood pressure in children  

Directory of Open Access Journals (Sweden)

Full Text Available Objetivos: Identificar fatores associados a níveis elevados de pressão arterial em crianças. Métodos: Estudo transversal da pressão arterial de 672 crianças entre 2 e 11 anos de idade em duas instituições de ensino de Belo Horizonte, entre setembro e dezembro de 2001. A pressão arterial foi mensurada seguindo os parámetros estabelecidos pelo relatório do Update on the 1987 Task Force Report on High Blood Pressure in Children and Adolescents. As seguintes variáveis foram estudadas: idade, sexo, cor da pele, índice de qualidade de vida urbana, estatura e índice de massa corporal. Para a comparação das médias, foi utilizada a análise de variãncia, e para a comparação de proporções, o teste quiquadrado. As variãveis associadas a níveis mais elevados de pressão arterial foram incluídas em análise de regressão linear múltipla. Resultados: Na análise univariada, níveis mais elevados de pressão arterial sistólica e diastólica estiveram associados com crianças de cor branca, crianças da região com alto índice de qualidade de vida urbana e com elevado índice de massa corporal. Na análise multivariada, apenas o índice de massa corporal, o índice de qualidade de vida urbana e a estatura mantiveram-se associados com níveis elevados de pressão sistólica. Em relação aos níveis mais elevados de pressão arterial diastólica, apenas as variáveis índice de qualidade de vida urbana e idade foram mantidas no modelo após o ajustamento. Conclusão: O sobrepeso e a obesidade estiveram associados com níveis mais elevados de pressão arterial sistólica. Outros fatores, não identificados, foram parcialmente associados a níveis mais elevados de pressão arterial de crianças do estabelecimento privado do ensinoTo identify factors associated with increased arterial blood pressure in children. Methods: In this cross-sectional study, arterial blood pressure was measured in 672 children between 2 and 11 years of age from two schools in the city of Belo Horizonte, Brazil. After providing informed consent, all children had their blood pressure and anthropometric parameters measured. Blood pressure was measured based on the recommendations of the Update on the 1987 Task Force Report on High Blood Pressure in Children and Adolescents. The following variables were assessed: age, sex, race, urban life quality index, weight, height, and body mass index. Analysis of variance was used for comparison of means and the chi-square was used for comparison of proportions. Variables associated with increased blood pressure were included in a multiple regression model. Results: According to univariate analysis, increased systolic and diastolic blood pressure were associated with high urban life quality index, white race and high body mass index. On multivariate analysis, body mass index, urban life quality index and height remained associated with increased systolic blood pressure; urban life quality index and age were associated with increased diastolic blood pressure. Conclusion: In this study, excess weight and obesity were associated with increased systolic blood pressure. Other unidentified factors were partially associated with increased blood pressure in children from the school with elevated urban life quality index

Frederico D Garcia

2006-10-01

155

Avaliação de fatores de risco associados com elevação da pressão arterial em crianças Evaluation of risk factors associated with increased blood pressure in children  

Directory of Open Access Journals (Sweden)

Full Text Available OBJETIVOS: Identificar fatores associados a níveis elevados de pressão arterial em crianças. MÉTODOS: Estudo transversal da pressão arterial de 672 crianças entre 2 e 11 anos de idade em duas instituições de ensino de Belo Horizonte, entre setembro e dezembro de 2001. A pressão arterial foi mensurada seguindo os parâmetros estabelecidos pelo relatório do Update on the 1987 Task Force Report on High Blood Pressure in Children and Adolescents. As seguintes variáveis foram estudadas: idade, sexo, cor da pele, índice de qualidade de vida urbana, estatura e índice de massa corporal. Para a comparação das médias, foi utilizada a análise de variância, e para a comparação de proporções, o teste qui-quadrado. As variáveis associadas a níveis mais elevados de pressão arterial foram incluídas em análise de regressão linear múltipla. RESULTADOS: Na análise univariada, níveis mais elevados de pressão arterial sistólica e diastólica estiveram associados com crianças de cor branca, crianças da região com alto índice de qualidade de vida urbana e com elevado índice de massa corporal. Na análise multivariada, apenas o índice de massa corporal, o índice de qualidade de vida urbana e a estatura mantiveram-se associados com níveis elevados de pressão sistólica. Em relação aos níveis mais elevados de pressão arterial diastólica, apenas as variáveis índice de qualidade de vida urbana e idade foram mantidas no modelo após o ajustamento. CONCLUSÃO: O sobrepeso e a obesidade estiveram associados com níveis mais elevados de pressão arterial sistólica. Outros fatores, não identificados, foram parcialmente associados a níveis mais elevados de pressão arterial de crianças do estabelecimento privado do ensino.OBJECTIVE: To identify factors associated with increased arterial blood pressure in children. METHODS: In this cross-sectional study, arterial blood pressure was measured in 672 children between 2 and 11 years of age from two schools in the city of Belo Horizonte, Brazil. After providing informed consent, all children had their blood pressure and anthropometric parameters measured. Blood pressure was measured based on the recommendations of the Update on the 1987 Task Force Report on High Blood Pressure in Children and Adolescents. The following variables were assessed: age, sex, race, urban life quality index, weight, height, and body mass index. Analysis of variance was used for comparison of means and the chi-square was used for comparison of proportions. Variables associated with increased blood pressure were included in a multiple regression model. RESULTS: According to univariate analysis, increased systolic and diastolic blood pressure were associated with high urban life quality index, white race and high body mass index. On multivariate analysis, body mass index, urban life quality index and height remained associated with increased systolic blood pressure; urban life quality index and age were associated with increased diastolic blood pressure. CONCLUSION: In this study, excess weight and obesity were associated with increased systolic blood pressure. Other unidentified factors were partially associated with increased blood pressure in children from the school with elevated urban life quality index.

Frederico D Garcia

2004-02-01

156

Effect of kefir and low-dose aspirin on arterial blood pressure measurements and renal apoptosis in unhypertensive rats with 4 weeks salt diet.  

Science.gov (United States)

Abstract We aim to study the effect of low-dose aspirin and kefir on arterial blood pressure measurements and renal apoptosis in unhypertensive rats with 4 weeks salt diet. Forty adult male Sprague-Dawley rats were divided into five groups: control, high-salt (HS) (8.0% NaCl), HS+aspirin (10 mg/kg), HS+kefir (10.0%w/v), HS+aspirin?+kefir. We measured sistolic blood pressure (SBP), mean arterial pressure (MAP), diastolic pressure, pulse pressure in the rats. Cathepsin B, L, DNA fragmentation and caspase-3 activities were determined from rat kidney tissues and rats clearance of creatinine calculated. Although HS diet increased significantly SBP, MAP, diastolic pressure, pulse pressure parameters compared the control values. They were not as high as accepted hypertension levels. When compared to HS groups, kefir groups significantly decrease Cathepsin B and DNA fragmentation levels. Caspase levels were elevated slightly in other groups according to control group. While, we also found that creatinine clearance was higher in HS+kefir and HS+low-dose aspirin than HS group. Thus, using low-dose aspirin had been approximately decreased of renal function damage. Kefir decreased renal function damage playing as Angiotensin-converting enzyme inhibitor. But, low-dose aspirin together with kefir worsened rat renal function damage. Cathepsin B might play role both apoptosis and prorenin-processing enzyme. But not caspase pathway may be involved in the present HS diet induced apoptosis. In conclusion, kefir and low-dose aspirin used independently protect renal function and renal damage induced by HS diet in rats. PMID:23631764

Kanbak, Güngör; Uzuner, Kubilay; Ku?at Ol, Kevser; O?lakç?, Ay?egül; Kartkaya, Kaz?m; ?entürk, Hakan

2014-01-01

157

Relation of systolic, diastolic, and pulse pressures and aortic distensibility with atrial fibrillation (from the Multi-Ethnic Study of Atherosclerosis).  

Science.gov (United States)

Previous research suggests that elevated pulse pressure (PP) is a risk factor for atrial fibrillation (AF) independently of mean arterial pressure (MAP). PP may serve as an indirect measure of aortic stiffness (reduced distensibility), but whether directly measured aortic distensibility is related to risk for AF has not yet been studied. This analysis included 6,630 participants aged 45 to 84 years from the Multi-Ethnic Study of Atherosclerosis. At baseline, blood pressure and other relevant covariates were measured using standardized protocols. Magnetic resonance imaging-based aortic distensibility was measured in 3,441 participants. Incident AF was identified from hospitalization discharge codes and Medicare claims. Multivariate Cox models were used to estimate the association of blood pressure components and aortic distensibility with AF risk. During a mean follow-up of 7.8 years, 307 AF events (137 among those with aortic distensibility measurements) were identified. In multivariate-adjusted models simultaneously including MAP and PP, each 1-SD increase in PP was associated with a 29% increased risk of AF (95% confidence interval 5% to 59%, p = 0.02), with MAP not being associated with increased AF risk. Overall, aortic distensibility was not consistently associated with AF risk: after removing outliers, each 1-SD increase in aortic distensibility was associated with a 9% increased risk of AF (95% confidence interval -22% to 51%, p = 0.63). In conclusion, in this large community-based cohort, we found that PP, but not MAP or aortic distensibility, was a significant risk factor for AF, emphasizing the importance of PP when assessing the risk for developing AF. Our results cast doubt on the clinical utility of aortic distensibility as a predictor for the development of AF. PMID:24996553

Roetker, Nicholas S; Chen, Lin Y; Heckbert, Susan R; Nazarian, Saman; Soliman, Elsayed Z; Bluemke, David A; Lima, João A C; Alonso, Alvaro

2014-08-15

158

Intraspecific scaling of arterial blood pressure in the Burmese python.  

Science.gov (United States)

Interspecific allometric analyses indicate that mean arterial blood pressure (MAP) increases with body mass of snakes and mammals. In snakes, MAP increases in proportion to the increased distance between the heart and the head, when the heart-head vertical distance is expressed as ?gh (where ? is the density of blood, G: is acceleration due to gravity and h is the vertical distance above the heart), and the rise in MAP is associated with a larger heart to normalize wall stress in the ventricular wall. Based on measurements of MAP in Burmese pythons ranging from 0.9 to 3.7 m in length (0.20-27 kg), we demonstrate that although MAP increases with body mass, the rise in MAP is merely half of that predicted by heart-head distance. Scaling relationships within individual species, therefore, may not be accurately predicted by existing interspecific analyses. PMID:24737752

Enok, Sanne; Slay, Christopher; Abe, Augusto S; Hicks, James W; Wang, Tobias

2014-07-01

159

Dependency of myocardial reactive hyperemia on coronary artery pressure in the dog.  

Science.gov (United States)

We studied the effects of coronary artery pressure on myocardial reactive hyperemia following brief flow arrests in 20 closed-chest anesthetized dogs. The circumflex artery was perfused from a pressurized arterial reservoir with a cannula inserted through the right carotid artery. Increasing coronary pressure from 60 to 160 mmHg did not alter heart rate, systemic pressure, or left ventricular dP/dtmax. For 10-s inflow occlusions, 20-mmHg increments in coronary pressure from 40 to 160 mmHg resulted in proportional increases in peak hyperemic flow [40 +/- 4 to 257 +/- 18 (SE) ml/min], total hyperemic flow (2 +/- 1 to 42 +/- 4 ml), and the duration of hyperemic flow (9 +/- 2 to 37 +/- 3 s). These results were unchanged when preocclusion pressure was held constant and postocclusion pressure varied. The influence of coronary artery pressure on hyperemic flow was progressively less pronounced after occlusions of shorter duration. These data indicate that coronary artery pressure has a major influence on the characteristics of myocardial reactive hyperemia after brief periods of arterial flow arrest. The observed pressure dependency suggests that coronary reactive hyperemia may be, in part, a passive flow response that could be explained by a transient depression of the normal vascular reactivity to postocclusion pressure. A passive component to reactive hyperemia could account for the overrepayment of bloow flow debt characteristically observed in the heart. PMID:7235030

Dole, W P; Montville, W J; Bishop, V S

1981-05-01

160

Slit lamp ophthalmodynamometry in internal carotid artery insufficiency  

Directory of Open Access Journals (Sweden)

Full Text Available Slit lamp ophthalmodynamometry was done by Dynoptor instrument in 6 cases of internal carotid artery, insufficiency, 18 cases of middle cerebral artery thrombosis and 20 control cases free from neurological disease. The average difference between the ophthalmic artery pressures of the two sides was 7.6% (diastolic and 4.8% (systolic in control cases. It was 6.6% (diastolic and 4.6% (systolic in cases of middle cerebral artery thrombosis. This difference was much higher in cases of -sub internal carotid artery insufficiency (41.3% ?diastolic and 25.4% in systolic; thus elucidating the role of ophthalmodynamometry as a non-invasive technique in diagnosis of these cases.

Nath Rajiv

1987-01-01

 
 
 
 
161

Stiffness Indices and Fractal Dimension relationship in Arterial Pressure and Diameter Time Series in-Vitro  

International Nuclear Information System (INIS)

The advent of vascular diseases, such as hypertension and atherosclerosis, is associated to significant alterations in the physical properties of arterial vessels. Evaluation of arterial biomechanical behaviour is related to the assessment of three representative indices: arterial compliance, arterial distensibility and arterial stiffness index. Elasticity is the most important mechanical property of the arterial wall, whose natures is strictly non-linear. Intervention of elastin and collagen fibres, passive constituent elements of the arterial wall, is related to the applied wall stress level. Concerning this, appropriate tools are required to analyse the temporal dynamics of the signals involved, in order to characterize the whole phenomenon. Fractal geometry can be mentioned as one of those techniques. The aim of this study consisted on arterial pressure and diameter signals processing, by means of nonlinear techniques based on fractal geometry. Time series morphology was related to different arterial stiffness states, generated by means of blood flow variations, during experiences performed in vitro.

162

Stiffness Indices and Fractal Dimension relationship in Arterial Pressure and Diameter Time Series in-Vitro  

Science.gov (United States)

The advent of vascular diseases, such as hypertension and atherosclerosis, is associated to significant alterations in the physical properties of arterial vessels. Evaluation of arterial biomechanical behaviour is related to the assessment of three representative indices: arterial compliance, arterial distensibility and arterial stiffness index. Elasticity is the most important mechanical property of the arterial wall, whose natures is strictly non-linear. Intervention of elastin and collagen fibres, passive constituent elements of the arterial wall, is related to the applied wall stress level. Concerning this, appropriate tools are required to analyse the temporal dynamics of the signals involved, in order to characterize the whole phenomenon. Fractal geometry can be mentioned as one of those techniques. The aim of this study consisted on arterial pressure and diameter signals processing, by means of nonlinear techniques based on fractal geometry. Time series morphology was related to different arterial stiffness states, generated by means of blood flow variations, during experiences performed in vitro.

Cymberknop, L.; Legnani, W.; Pessana, F.; Bia, D.; Zócalo, Y.; Armentano, R. L.

2011-12-01

163

Avaliação da hipertensão arterial resistente pela monitorização residencial da pressão arterial / Assessment of resistant hypertension with home blood pressure monitoring / Evaluación de la hipertensión arterial resistente por monitoreo residencial de la presión arterial  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese FUNDAMENTO: A monitorização ambulatorial da pressão arterial (MAPA) é considerada o padrão-ouro para a confirmação diagnóstica da hipertensão arterial resistente (HAR). No entanto, a monitorização residencial da pressão arterial (MRPA) tem sido considerada uma opção, pelo seu custo menor e maior con [...] forto. OBJETIVO: Comparar os valores obtidos pela MRPA com os obtidos pela MAPA na identificação de pacientes hipertensos resistentes. MÉTODOS: Foram selecionados consecutivamente 51 pacientes hipertensos resistentes, adultos de ambos os sexos, em tratamento ambulatorial de referência, de jan/2007 a set/2009. A medida da pressão arterial (PA) casual de consultório, MAPA de 24 horas e MRPA foram realizadas conforme as diretrizes vigentes, com intervalo máximo de duas semanas entre os métodos. RESULTADOS: Ao comparar a MAPA (média de vigília) e MRPA, foi obtida boa correlação entre ambas, tanto para a pressão arterial sistólica (PAS) quanto para a diastólica (PAD): PAS r = 0,70, IC = 0,51-0,82; PAD r = 0,69, IC = 0,52-0,81. A HAR foi confirmada pela MAPA em 33 pacientes e pela MRPA em 37 desses, não havendo diferença significante entre os dois métodos. CONCLUSÃO: De acordo com os resultados obtidos, conclui-se que a MRPA é um exame que pode ser utilizado como alternativa à MAPA para a confirmação diagnóstica da HAR. Abstract in spanish FUNDAMENTO: El monitoreo ambulatorio de la presión arterial (MAPA) es considerado el gold standard para la confirmación diagnóstica de la hipertensión arterial resistente (HAR). Mientras tanto, el monitoreo residencial de la presión arterial (MRPA) ha sido considerado una opción, por su costo menor [...] y mayor confort. OBJETIVO: Comparar los valores obtenidos por la MRPA con los obtenidos por la MAPA en la identificación de pacientes hipertensos resistentes. MÉTODOS: Fueron seleccionados consecutivamente 51 pacientes hipertensos resistentes, adultos de ambos sexos, en tratamiento ambulatorio de referencia, de ene/2007-set/2009. La medida de la presión arterial (PA) casual de consultorio, MAPA de 24 horas y MRPA fueron realizadas según las directrices vigentes, con intervalo máximo de dos semanas entre los métodos. RESULTADOS: Al comparar la MAPA (media de vigilia) y MRPA, fue obtenida buena correlación entre ambas, tanto para la presión arterial sistólica (PAS) como para la diastólica (PAD): PAS r = 0,70, IC = 0,51-0,82; PAD r = 0,69, IC = 0,52-0,81. La HAR fue confirmada por la MAPA en 33 pacientes y por la MRPA en 37 de esos, no habiendo diferencia significativa entre los dos métodos. CONCLUSIÓN: De acuerdo con los resultados obtenidos, se concluye que la MRPA es un examen que puede ser utilizado como alternativa a la MAPA para la confirmación diagnóstica de la HAR. Abstract in english BACKGROUND: Ambulatory blood pressure monitoring (ABPM) is considered the gold standard for the diagnostic confirmation of resistant hypertension (RH). However, home blood pressure monitoring (HBPM) has been considered an option, because of its lower cost and greater comfort. OBJECTIVE: To compare t [...] he values obtained by HBPM with those obtained by ABPM in the identification of patients with resistant hypertension. METHODS: A total of 51 consecutive patients with resistant hypertension were selected. All were adults of both genders and were undergoing treatment in an outpatient referral clinic from January 2007 to September 2009. Casual office blood pressure (BP), 24-hour ABPM, and HBPM were performed according to current guidelines, with a maximum two-week interval between the methods. RESULTS: The comparison of ABPM (mean daytime) with HBPM showed a good correlation between them, both for systolic blood pressure (SBP) and for diastolic blood pressure (DBP): SBP r = 0.70, CI = 0.51-0.82, DBP r = 0.69, CI = 0.52-0.81. RH was confirmed by ABPM in 33 patients and by HBPM in 37, with no significant difference between the methods. CONCLUSION: According to the results

Fabiane Rosa Rezende H., Marui; Maria Teresa Nogueira, Bombig; Yoná Afonso, Francisco; José Marcos, Thalenberg; Francisco Antonio Helfenstein, Fonseca; Dilma de, Souza; Francisco de Assis, Costa; Maria Cristina, Izar; Antonio Carlos de Camargo, Carvalho; Rui, Póvoa.

164

Regulation of ocular blood flow during increases of arterial blood pressure.  

Digital Repository Infrastructure Vision for European Research (DRIVER)

The blood flow in the uvea in cats and monkeys during acute increases of arterial blood pressure is well controlled by a sympathetic mechanism protecting the eye from overperfusion. Ocular macrocirculation (ophthalmic artery) and ocular microcirculation (iris) were examined in 22 healthy subjects during acute increases of arterial blood pressure induced by physical exercise (125 W). With a data acquisition and storage software in real time mode several parameters of ocular perfusion and syste...

Michelson, G.; Groh, M.; Gru?ndler, A.

1994-01-01

165

Intra-arterial blood pressure response in hypertensive subjects during low- and high-intensity resistance exercise  

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Full Text Available OBJECTIVE: The aim of this study was to describe blood pressure responses during resistance exercise in hypertensive subjects and to determine whether an exercise protocol alters these responses. INTRODUCTION: Resistance exercise has been recommended as a complement for aerobic exercise for hypertensive patients. However, blood pressure changes during this kind of exercise have been poorly investigated in hypertensives, despite multiple studies of normotensives demonstrating significant increases in blood pressure. METHODS: Ten hypertensive and ten normotensive subjects performed, in random order, two different exercise protocols, composed by three sets of the knee extension exercise conducted to exhaustion: 40% of the 1-repetition maximum (1RM with a 45-s rest between sets, and 80% of 1RM with a 90-s rest between sets. Radial intra-arterial blood pressure was measured before and throughout each protocol. RESULTS: Compared with normotensives, hypertensives displayed greater increases in systolic BP during exercise at 80% (+80±3 vs. +62±2 mmHg, P<0.05 and at 40% of 1RM (+75±3 vs. +67±3 mmHg, P<0.05. In both exercise protocols, systolic blood pressure returned to baseline during the rest periods between sets in the normotensives; however, in the hypertensives, BP remained slightly elevated at 40% of 1RM. During rest periods, diastolic blood pressure returned to baseline in hypertensives and dropped below baseline in normotensives. CONCLUSION: Resistance exercise increased systolic blood pressure considerably more in hypertensives than in normotensives, and this increase was greater when lower-intensity exercise was performed to the point of exhaustion.

Sandra de Souza Nery

2010-01-01

166

Blood pressure changes in dogs with babesiosis  

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Full Text Available Systemic arterial blood pressures were measured in 30 dogs with acute babesiosis, 10 each with mild uncomplicated, severe uncomplicated and complicated disease. Ten healthy dogs were used as controls. Hypotension was defined as more than 3 standard deviations below the control mean. Normal mean pressures (±SD were: systolic arterial pressure 151 (±11 mm Hg, diastolic arterial pressure 89 (±8 mm Hg and mean arterial pressure 107 (±10 mmHg. Hypotension was the most frequent abnormality, and increased strikingly in incidence as disease severity increased, with 5/10 dogs in the complicated group being hypotensive for systolic, diastolic and mean arterial pressures, compared with 2/10 in the severe uncomplicated group and 0/10 in the mild uncomplicated group. Systolic, diastolic and mean arterial pressures in the complicated group and severe uncomplicated group, and systolic pressure in the mild uncomplicated group, were significantly lower than in the controls. There were no significant relationships between arterial pressures and age, pulse rate, respiratory rate, temperature, mucous membrane colour or haematocrit. There was a significant negative correlation between arterial pressures and white cell and immature neutrophil counts. Arterial pressures differed significantly between dogs that were clinically collapsed and those that were not, but not between survivors and non-survivors. Pulse pressure (systolic - diastolic was low in 7/10 complicated, 1/10 mild uncomplicated, and 1/10 severe uncomplicated cases, and differed significantly between the complicated and control groups. The high incidence of hypotension in clinically severe babesiosis has important implications for therapy.

L.S. Jacobson

2012-07-01

167

Exercise training improves mean arterial pressure in breast cancer survivors  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in portuguese "O exercício físico melhora a pressão arterial média em sobreviventes de câncer de mama."Atualmente, muitos sobreviventes de câncer de mama em todo o mundo vivem com os efeitos secundários relacionados com o tratamento, incluindo problemas de saúde cardiovascular. Este estudo examinou os efeitos de [...] uma intervenção de exercício de 5 meses com marcadores não-invasivos de saúde cardiovascular em sobreviventes de câncer de mama. As relações entre esses marcadores e os marcadores mais utilizados de saúde em geral também foram exploradas. Cinquenta e duas sobreviventes completaram o treinamento em um centro de reabilitação da Universidade da Carolina do Norte em Chapel Hill entre 2008-2011. Foram implementadas intervenção combinando exercício aeróbio e resistido (3 vezes / semana durante 1h) em intensidades progredindo de baixo (40%) a moderada (65-70% do VO2max) para exercícios aeróbios, e 8-12 repetições máxima para o exercício de resistência. Redução significativa da pressão arterial média (PAM) foi observada a partir da linha de base para avaliação final. Foi encontrada uma correlação significativa entre o MAPA e Índice de Massa Corporal (IMC). Em conclusão, 5 meses de intervenção com exercícios combinados de resistência e aeróbio melhorou positivamente o MAP, que foi, em parte, atribuída a mudanças no IMC. Abstract in spanish "El ejercicio físico mejora la presión arterial media en los sobrevivientes de cáncer de mama."Actualmente, muchos de los sobrevivientes de cáncer de mama en todo el mundo viven con los efectos secundarios relacionados con el tratamiento, incluyendo problemas de salud cardiovascular. Este estudio ex [...] aminó los efectos de una intervención de ejercicio durante cinco meses con marcadores no invasivos de la salud cardiovascular en sobrevivientes de cáncer de seno. También se exploraron las relaciones entre estos marcadores y los marcadores más utilizados de la salud general. Cincuenta y dos sobrevivientes completaron la formación en un centro de rehabilitación en la Universidad de Carolina del Norte en Chapel Hill de 2008 a 2011. Intervención se implementara la combinación de ejercicio aeróbico y de resistencia (3 veces / semana durante 1 h) a intensidades que van de la baja (40%) o moderada (65-70% VO2max) para el ejercicio aeróbico, y 8-12 repeticiones máximas para el ejercicio de resistencia. Se observó una reducción significativa de la presión arterial media (MAP) desde el inicio hasta la evaluación final. Se encontró una correlación significativa entre el MAPA y el Índice de Masa Corporal (IMC). En conclusión, a cinco meses de intervención con ejercicio aeróbico y de resistencia combinado mejoraron positivamente el MAP, que se atribuye en parte a los cambios en el IMC. Abstract in english Currently, many breast cancer survivors worldwide live with treatment-related side effects, including cardiovascular health problems. This study examined effects of a 5-month exercise intervention on non-invasive markers of cardiovascular health in breast cancer survivors. Relationships between thes [...] e markers and commonly used markers of overall health were also explored. Fifty-two survivors completed the exercise training at a rehabilitation center at the University of North Carolina at Chapel Hill between 2008-2011. A combined aerobic and resistance exercise intervention (3 times/week for 1h) at intensities progressing from low (40%) to moderate (65-70% of VO2max) for aerobic and 8-12 repetitions max for the resistance exercise were implemented. Significant reduction in mean arterial pressure (MAP) was observed from baseline to final assessment. A significant correlation was found between MAP and Body Mass Index (BMI). In conclusion, 5-months combined aerobic and resistance exercise intervention positively improved MAP which was, in part, attributed to changes in BMI.

Robert, C. Mills; Marcelo G. B., Nascimento; Gislane F. de, Melo; Anthony C., Hackney; Claudio L., Battaglini.

2014-09-01

168

Exercise training improves mean arterial pressure in breast cancer survivors  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in portuguese "O exercício físico melhora a pressão arterial média em sobreviventes de câncer de mama."Atualmente, muitos sobreviventes de câncer de mama em todo o mundo vivem com os efeitos secundários relacionados com o tratamento, incluindo problemas de saúde cardiovascular. Este estudo examinou os efeitos de [...] uma intervenção de exercício de 5 meses com marcadores não-invasivos de saúde cardiovascular em sobreviventes de câncer de mama. As relações entre esses marcadores e os marcadores mais utilizados de saúde em geral também foram exploradas. Cinquenta e duas sobreviventes completaram o treinamento em um centro de reabilitação da Universidade da Carolina do Norte em Chapel Hill entre 2008-2011. Foram implementadas intervenção combinando exercício aeróbio e resistido (3 vezes / semana durante 1h) em intensidades progredindo de baixo (40%) a moderada (65-70% do VO2max) para exercícios aeróbios, e 8-12 repetições máxima para o exercício de resistência. Redução significativa da pressão arterial média (PAM) foi observada a partir da linha de base para avaliação final. Foi encontrada uma correlação significativa entre o MAPA e Índice de Massa Corporal (IMC). Em conclusão, 5 meses de intervenção com exercícios combinados de resistência e aeróbio melhorou positivamente o MAP, que foi, em parte, atribuída a mudanças no IMC. Abstract in spanish "El ejercicio físico mejora la presión arterial media en los sobrevivientes de cáncer de mama."Actualmente, muchos de los sobrevivientes de cáncer de mama en todo el mundo viven con los efectos secundarios relacionados con el tratamiento, incluyendo problemas de salud cardiovascular. Este estudio ex [...] aminó los efectos de una intervención de ejercicio durante cinco meses con marcadores no invasivos de la salud cardiovascular en sobrevivientes de cáncer de seno. También se exploraron las relaciones entre estos marcadores y los marcadores más utilizados de la salud general. Cincuenta y dos sobrevivientes completaron la formación en un centro de rehabilitación en la Universidad de Carolina del Norte en Chapel Hill de 2008 a 2011. Intervención se implementara la combinación de ejercicio aeróbico y de resistencia (3 veces / semana durante 1 h) a intensidades que van de la baja (40%) o moderada (65-70% VO2max) para el ejercicio aeróbico, y 8-12 repeticiones máximas para el ejercicio de resistencia. Se observó una reducción significativa de la presión arterial media (MAP) desde el inicio hasta la evaluación final. Se encontró una correlación significativa entre el MAPA y el Índice de Masa Corporal (IMC). En conclusión, a cinco meses de intervención con ejercicio aeróbico y de resistencia combinado mejoraron positivamente el MAP, que se atribuye en parte a los cambios en el IMC. Abstract in english Currently, many breast cancer survivors worldwide live with treatment-related side effects, including cardiovascular health problems. This study examined effects of a 5-month exercise intervention on non-invasive markers of cardiovascular health in breast cancer survivors. Relationships between thes [...] e markers and commonly used markers of overall health were also explored. Fifty-two survivors completed the exercise training at a rehabilitation center at the University of North Carolina at Chapel Hill between 2008-2011. A combined aerobic and resistance exercise intervention (3 times/week for 1h) at intensities progressing from low (40%) to moderate (65-70% of VO2max) for aerobic and 8-12 repetitions max for the resistance exercise were implemented. Significant reduction in mean arterial pressure (MAP) was observed from baseline to final assessment. A significant correlation was found between MAP and Body Mass Index (BMI). In conclusion, 5-months combined aerobic and resistance exercise intervention positively improved MAP which was, in part, attributed to changes in BMI.

Robert, C. Mills; Marcelo G. B., Nascimento; Gislane F. de, Melo; Anthony C., Hackney; Claudio L., Battaglini.

169

Medida da pressão arterial no braço e antebraço em função do manguito / Arm and forearm blood pressure measurements as a function of cuff width / Medida de la presión arterial en el brazo y antebrazo en función del manguito  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese OBJETIVO: Identificar e comparar os níveis de pressão arterial no braço e antebraço usando manguitos de dimensões apropriadas e o manguito padrão. MÉTODOS: Estudo transversal com 103 indivíduos, aplicando a razão circunferência braquial (CB) /largura de manguito de 0,40 nos dois segmentos, e registr [...] os com o manguito padrão após um minuto. razão CB /comprimento do manguito de 0,80, correto ou padrão, circunferências medidas no ponto médio de cada segmento. RESULTADOS: Diferenças significativas indicaram hiperestimação da pressão diastólica no antebraço, menor daquela observada em outros estudos. A manobra de Forsberg melhorou a audibilidade dos sons de Korotkoff. CONCLUSÃO: Os achados indicam que o manguito correto diminui a hiperestimação dos registros diastólicos observada por outros autores. O avanço no conhecimento da medida no antebraço requer outros estudos. Abstract in spanish OBJETIVO:Identificar y comparar los niveles de presión arterial en el brazo y antebrazo usando manguitos de dimensiones apropiadas y el manguito patrón. MÉTODOS: Se trata de un estudio transversal realizado con 103 individuos, aplicando la razón circunferencia braquial (CB) /ancho del manguito de 0, [...] 40 en los dos segmentos, y registros con el manguito patrón después un minuto, razón CB /largo del manguito de 0,80, correcto o patrón, circunferencias medidas en el punto medio de cada segmento. RESULTADOS: Diferencias significativas indicaron hiperestimación de la presión diastólica en el antebrazo, menor de aquella observada en otros estudios. La maniobra de Forsberg mejoró la audibilidad de los sonidos de Korotkoff. CONCLUSIÓN: Los hallazgos indican que el manguito correcto disminuye la hiperestimación de los registros diastólicos observada por otros autores. El avance en el conocimiento de la medida en el antebrazo requiere de otros estudios. Abstract in english OBJECTIVE: To identify and compare arm and forearm blood pressure measurements using appropriate cuff sizes versus a usual standard cuff. METHODS: A cross-sectional comparative study was used. Blood pressure was measured in 103 individuals using a 0.40 cuff width and 0.80 cuff length on both segment [...] s and followed by a measure with a usual standard cuff after one minute. Arm and forearm circumferences were measured at the middle point. RESULTS: Significant differences indicated overestimation of diastolic blood pressure in the forearm. These differences were lower than differences reported in other studies. Korotkoff sounds were improved after Forsberg's maneuver. CONCLUSION: Although, we found an overestimation of diastolic blood pressure in forearm, other studies suggest that the use of appropriate cuff sizes in the forearm derive more accurate measures of diastolic blood pressure. There is a need to study further measurements of blood pressure in the forearm.

Edna Apparecida Moura, Arcuri; Solange Cristina Denzin, Rosa; Rosa Maria, Scanavini; Gesiane de Salles Cardin, Denzin.

170

Effect of iohexol and diatrizoate on pulmonary arterial pressure following pulmonary angiography  

International Nuclear Information System (INIS)

A clinical comparison of the effects on pulmonary arterial pressure produced by iohexol and diatrizoate, following selective pulmonary angiography, was made in 17 patients with a normal pressure before the injection of the contrast medium. A double blind crossover study was performed and each contrast medium was administered in random order. The pulmonary arterial pressure was continuously recorded before, during and after the injection for 3 minutes. The effect of iohexol on the pulmonary arterial pressure was significantly less than that of diatrizoate. The results indicated that iohexol should be better tolerated than diatrizoate and therefore a safer contrast medium for selective pulmonary angiography. (orig.)

171

Exercise-Echocardiography–Derived Pulmonary Artery Pressure Slope in Borderline and Mild to Moderate Pulmonary Arterial Hypertension  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Objective: Examine pulmonary artery systolic pressure (PASP) response to exercise in isolated borderline and mild to moderate pulmonary arterial hypertension (PAH).Methods: Doppler stress echocardiography was performed in 32 healthy volunteers with resting PASP of 29 mm Hg or less, 39 with resting PASP between 30 and 40 mm Hg, and 7 with resting PASP between 41 and less than 60 mm Hg. All subjects had otherwise normal echocardiograms.Results: Rate of increase in PASP with exercise was posit...

Ammash, Naser M.; Mcgoon, Michael D.; Clarence Shub; Seward, James B.; Oh, Jae K.; Krowka, Michael J.; Pellikka, Patricia A.; Moon, Brenda S.; Bailey, Kent R.; Wood, Christina M.; Jamil Tajik, A.

2008-01-01

172

Diets rich in conjugated linoleic acid and vaccenic acid have no effect on blood pressure and isobaric arterial elasticity in healthy young men  

DEFF Research Database (Denmark)

The objective of this study was to examine the effect on blood pressure (BP) and isobaric arterial elasticity (AE), as a measure of arterial health, of a commercial mixture of conjugated linoleic acids (CLA) and of milk fat produced through livestock feeding to have a high content of vaccenic acid (VA). Healthy young men (n = 60) with a BMI of 22.5 +/- 2 kg/m(2) (mean +/- SD) participated in this double-blind, randomized, 5-wk, parallel intervention study. The participants substituted 115 g of their daily fat intake with fat from 1 of 3 test diets: 1) CLA-diet rich in CLA (4.7 g/d of c9, t11- and t10, c12-CLA isomers in equal amounts); 2) VA-diet rich in VA (3.6 g/d); or 3) C-diet, a control diet with a low content of VA and CLA. All test diets were based on milk fat. BP and AE (measured by an oscillometric method) were measured before and after the intervention period. The effects of the test diets did not differ on any outcome variable: e.g., systolic- and diastolic blood pressure (SBP and DBP), pulse pressure (PP), isobaric arterial compliance (AC), distensibility (AD), or volume (AV). In conclusion, diets rich in milk fat and either CLA or VA have no effect on BP or AE indices in healthy young men compared with a control diet.

Straarup, Ellen Marie

2006-01-01

173

Diastolic myofilament dysfunction in the failing human heart  

Digital Repository Infrastructure Vision for European Research (DRIVER)

In recent years, it has become evident that heart failure is not solely due to reduced contractile performance of the heart muscle as impaired relaxation is evident in almost all heart failure patients. In more than half of all heart failure patients, diastolic dysfunction is the major cardiac deficit. These heart failure patients have normal (or preserved) left ventricular ejection fraction, but impaired diastolic function evident from increased left ventricular end-diastolic pressure. Pertu...

Velden, J.

2011-01-01

174

Digital models for arterial pressure and respiratory waveforms.  

Science.gov (United States)

Digital models for arterial pressure pulse (APP) and respiratory volume waveforms (RVW) are proposed for efficient representation of these signals. When these signals are discrete cosine transformed (DCT), the pole-zero technique of Steiglitz-McBride (SM) gave system functions of much lower order than those obtained directly from the signals. The DCT of a bell-shaped biphasic wave needed two poles and two zeros. Based on this, the model order is fixed by the number of distinct peaks in the magnitude spectrum of the transformed APP/RVW signal. The partial fraction expansion (PFE) of the system function allowed delineation of component waves present in the time signal. The angles of model poles and zeros enabled easy determination of several important features from both of these signals. The model performance is evaluated using the normalized root mean-square error (NRMSE). A Bayes classifier using the pole angles as the feature vector performed satisfactorily when a limited number of RVW's recorded under deep and rapid maneuver are classified into normal (n) and abnormal (ab) categories of respiratory pathways. PMID:8258438

Murthy, I S; Sita, G

1993-08-01

175

A pressão arterial está sendo medida? Is the blood pressure being measured?  

Directory of Open Access Journals (Sweden)

Full Text Available A medida da pressão arterial faz parte do exame físico e deve ser realizada em toda consulta médica. Para avaliar se a pressão arterial é medida nas consultas médicas, foram consultados 500 prontuários de pacientes de primeira consulta ambulatorial, sendo 335 (67% provenientes de clínicas médicas e cirúrgicas e 165 (33% das clínicas ginecológica e obstétrica. A pressão arterial foi anotada em 39% das consultas realizadas (135±32/85±19 mm Hg, sendo que em 11% destas anotações a pressão diastólica estava acima de 90 mm Hg. Em relação ao diagnóstico prévio de hipertensão arterial verificou-se que: a em 62% dos prontuários não havia esta informação; b 20% referiram ter hipertensão, e em 79% destes a pressão arterial foi anotada; e c 18% referiram não ter hipertensão e 46% destes tiveram registro da pressão arterial. Portanto, a maior parte dos pacientes não teve sua pressão arterial anotada.The blood pressure measure is part of the physical exam and it should be accomplished in every medical consultation. To verify the blood pressure measured in the accomplished medical consultations record of first they were consulted it consults 500 patient's ambulatorial being 335 (67% coming of medical and surgical clinics and 165 (33% of the gynecological and obstetric clinics. The blood pressure was written down in 39% of the accomplished consultations (135+32 mm Hg 85+19 mm Hg, and 11% of this annotations the pressure diastólica was above 90 mm Hg. In relation to the previous diagnosis of hypertension it was verified that: a in 62% of the records there was not this information; b 20% referred to have hypertension, and in 79% of these the arterial pressure was scored; and c 18% referred not to have hypertension and 46% of these had registration of the arterial pressure. Therefore, most of the patients didn't have its logged arterial pressure.

Débora C. Alavarce

2000-03-01

176

Ductus venosus flow velocity in newborn lambs during increased pulmonary artery pressure.  

Science.gov (United States)

The aim of the present study was to assess with ultrasound the ductus venosus flow velocity in newborn lambs with increasing pulmonary artery pressures and to evaluate whether this is a useful method to detect elevated pulmonary artery pressure. The ductus venosus flow velocity was studied with pulsed-wave Doppler echocardiography in nine newborn lambs precordial veins, shows a reduction and even reversal of the nadir and an increase of the duration of reversed flow during atrial systole as a response to increased pulmonary artery pressure. Thus, Doppler ultrasound of the ductus venosus flow velocity may be a useful noninvasive diagnostic supplement to detect pulmonary hypertension of the newborn. PMID:10832735

Fugelseth, D; Leach, C L; Morin, F C; Liestøl, K; Wang, H; Swartz, D; Lindemann, R

2000-06-01

177

Drinking and arterial blood pressure responses to ANG II in young and old rats  

Digital Repository Infrastructure Vision for European Research (DRIVER)

We investigated water drinking and arterial blood pressure responses to intravenous infusions of ANG II in young (4 mo), middle-aged adult (12 mo), and old (29 mo) male Brown Norway rats. Infusions of ANG II began with arterial blood pressure either at control levels or at reduced levels following injection of the vasodilator minoxidil. Under control conditions, mean arterial pressure (MAP) in response to ANG II rose to the same level for all groups, and middle-aged and old rats drank as much...

Thunhorst, Robert L.; Beltz, Terry G.; Johnson, Alan Kim

2010-01-01

178

Avaliação das pressões sistólica, diastólica e pressão de pulso como fator de risco para doença aterosclerótica coronariana grave em mulheres com angina instável ou infarto agudo do miocárdio sem supradesnivelamento do segmento ST / Evaluation of systolic, diastolic, and pulse pressure as risk factors for severe coronary arteriosclerotic disease in women with unstable angina non-ST-elevation acute myocardial infarction  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese OBJETIVO: Avaliar se as pressões, medidas na raiz da aorta, são fatores de risco para doença aterosclerótica coronariana grave em mulheres com angina instável ou infarto agudo do miocárdio sem supradesnivelamento do segmento ST (AI/IAMSS). MÉTODO:As pressões, assim como os fatores de risco para doen [...] ça arterial coronariana (DAC) foram prospectivamente coletados de março/1993 a agosto/2001 em 593 mulheres com diagnóstico de AI/IAMSS submetidas à cinecoronariografia. Lesões coronarianas definidas como graves estenoses > 70%. RESULTADOS: Idade média de 59,2±11,2 anos, significantemente mais alta nas pacientes com DAC: 61,9 ± 10,8 anos vs 56.4 ± 10,8 anos; tabagismo, diabetes e climatério foram mais freqüentes nas pacientes com DAC. As médias das pressões sistólica e arterial média foram iguais nos dois grupos, entretanto as médias das pressões diastólicas do ventrículo esquerdo (17.6 ± 8.7 x 15.1 ± 8.1, p=0.001) e da pressão de pulso aórtica foram significantemente maiores nas pacientes com DAC (75.5 ± 22 x 70 ± 19, p=0.002), enquanto a média da pressão diastólica aórtica foi significantemente mais alta nas pacientes sem DAC (75.3 ± 17.5 x 79.8 ± 16, p=0.003). Na análise multivariada a pressão de pulso > 80 mmHg e pressão sistólica > 165 foram independentemente associadas a DAC com razão de chance de 2.12 e 2.09, p 80 mmHg e pressão sistólica > 165 mmHg determinaram risco duas vezes maior de lesão coronariana grave. Abstract in english OBJECTIVE: To evaluate pressures assessed at the aortic root as risk factors for severe atherosclerotic coronary heart disease in women with unstable angina/compatible clinical history associated with increase in cardiac enzymes (total CPK and CK-MB) 2 times greater than the standard value used in t [...] he hospital, with the absence of new Q waves on the electrocardiogram (UA/NSTEMI). METHODS: Five hundred and ninety-three female patients with clinical diagnosis of UA/NSTEMI underwent cinecoronariography from March 1993 to August 2001, and the risk factors for CHD were studied. During examination the pressures, at the aortic root, and coronary obstructions were visually assessed by 2 interventional cardiologists, and those stenosis over 70% were considered severe. RESULTS: Eight-one per cent of the population was white and 18.3% was black. Mean age was 59.2±11.2 years, and it was significantly higher in patients with severe coronary lesions: 61.9 ± 10.8 years versus 56.4 ± 10.8 years; smoking, diabetes mellitus and climacteric were more frequent in patients with CHD. The average mean arterial pressure and mean systolic blood pressure was the same in both groups, however, average left ventricle diastolic pressure (17.6 ± 8.7 x 15.1 ± 8.1, p=0.001), and aortic pulse pressure were significantly greater in patients with CHD (75.5 ± 22 x 70 ± 19, p=0.002), while average aortic diastolic pressure was significantly greater in patients without CHD (79.8 ± 16 x 75.3 ± 17.5, p=0.003). In the multivariated analysis, pulse pressure > 80 mmHg and systolic blood pressure > 165 were independently associated with severe CHD with odds ratio of 2.12 and 2.09, p 80 mmHg and systolic blood pressure > 165 mmHG determined risk two times greater of severe coronary disease.

José Marconi Almeida de, Sousa; João L. V., Hermann; João B., Guimarães; Pedro Paulo O., Menezes; Antonio Carlos Camargo, Carvalho.

179

Avaliação das pressões sistólica, diastólica e pressão de pulso como fator de risco para doença aterosclerótica coronariana grave em mulheres com angina instável ou infarto agudo do miocárdio sem supradesnivelamento do segmento ST / Evaluation of systolic, diastolic, and pulse pressure as risk factors for severe coronary arteriosclerotic disease in women with unstable angina non-ST-elevation acute myocardial infarction  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese OBJETIVO: Avaliar se as pressões, medidas na raiz da aorta, são fatores de risco para doença aterosclerótica coronariana grave em mulheres com angina instável ou infarto agudo do miocárdio sem supradesnivelamento do segmento ST (AI/IAMSS). MÉTODO:As pressões, assim como os fatores de risco para doen [...] ça arterial coronariana (DAC) foram prospectivamente coletados de março/1993 a agosto/2001 em 593 mulheres com diagnóstico de AI/IAMSS submetidas à cinecoronariografia. Lesões coronarianas definidas como graves estenoses > 70%. RESULTADOS: Idade média de 59,2±11,2 anos, significantemente mais alta nas pacientes com DAC: 61,9 ± 10,8 anos vs 56.4 ± 10,8 anos; tabagismo, diabetes e climatério foram mais freqüentes nas pacientes com DAC. As médias das pressões sistólica e arterial média foram iguais nos dois grupos, entretanto as médias das pressões diastólicas do ventrículo esquerdo (17.6 ± 8.7 x 15.1 ± 8.1, p=0.001) e da pressão de pulso aórtica foram significantemente maiores nas pacientes com DAC (75.5 ± 22 x 70 ± 19, p=0.002), enquanto a média da pressão diastólica aórtica foi significantemente mais alta nas pacientes sem DAC (75.3 ± 17.5 x 79.8 ± 16, p=0.003). Na análise multivariada a pressão de pulso > 80 mmHg e pressão sistólica > 165 foram independentemente associadas a DAC com razão de chance de 2.12 e 2.09, p 80 mmHg e pressão sistólica > 165 mmHg determinaram risco duas vezes maior de lesão coronariana grave. Abstract in english OBJECTIVE: To evaluate pressures assessed at the aortic root as risk factors for severe atherosclerotic coronary heart disease in women with unstable angina/compatible clinical history associated with increase in cardiac enzymes (total CPK and CK-MB) 2 times greater than the standard value used in t [...] he hospital, with the absence of new Q waves on the electrocardiogram (UA/NSTEMI). METHODS: Five hundred and ninety-three female patients with clinical diagnosis of UA/NSTEMI underwent cinecoronariography from March 1993 to August 2001, and the risk factors for CHD were studied. During examination the pressures, at the aortic root, and coronary obstructions were visually assessed by 2 interventional cardiologists, and those stenosis over 70% were considered severe. RESULTS: Eight-one per cent of the population was white and 18.3% was black. Mean age was 59.2±11.2 years, and it was significantly higher in patients with severe coronary lesions: 61.9 ± 10.8 years versus 56.4 ± 10.8 years; smoking, diabetes mellitus and climacteric were more frequent in patients with CHD. The average mean arterial pressure and mean systolic blood pressure was the same in both groups, however, average left ventricle diastolic pressure (17.6 ± 8.7 x 15.1 ± 8.1, p=0.001), and aortic pulse pressure were significantly greater in patients with CHD (75.5 ± 22 x 70 ± 19, p=0.002), while average aortic diastolic pressure was significantly greater in patients without CHD (79.8 ± 16 x 75.3 ± 17.5, p=0.003). In the multivariated analysis, pulse pressure > 80 mmHg and systolic blood pressure > 165 were independently associated with severe CHD with odds ratio of 2.12 and 2.09, p 80 mmHg and systolic blood pressure > 165 mmHG determined risk two times greater of severe coronary disease.

José Marconi Almeida de, Sousa; João L. V., Hermann; João B., Guimarães; Pedro Paulo O., Menezes; Antonio Carlos Camargo, Carvalho.

2004-05-01

180

Effect of volume reduction on diastolic echocardiographic parameters in hemodialyzed patients  

Directory of Open Access Journals (Sweden)

Full Text Available Background: Cardiovascular problems including arterial hypertension, coronary artery diseases, congestive heart failure are prevalent among chronic hemodialyzed patients. Ultrafiltration of hemodialyzed patient's serum, which culminating in intravascular volume reduction, is frequently used during hemodialysis. One of the restrictions of the echocardiographic evaluation of the diastolic heart function is the intravascular volume dependency of some echocardiographic parameters. In this study we have evaluated the volume dependency of certain echocardiography parameters in chronically hemodialyzed patients. Methods: Thirteen patients undergoing chronic hemodialysis in Ghaem Hospital Hemodialysis Center in Mashhad, Iran, were evaluated one hour before and immediately after hemodialysis for the following: all diastolic echocardiographic parameters, left ventricular function, left ventricular systolic function, inferior vena cava (IVC diameter and IVC collapsibility with inspiration, and systolic and diastolic blood pressure. The echocardiographic parameters were analyzed using the paired Student's t-test. Results: With hemodialysis, there was no significant change in left ventricular function, A wave amplitude and E/F slope, however, there was a significant reduction of the E wave amplitude, increment in E wave deceleration time (p= 0.001, t=-4.14 and a decrease in the E/A ratio (p=0.03, t=2.46. Tissue Doppler echocardiography showed no significant change in mitral annular diastolic motion, E'/A' waves, with hemodialysis (p=0.728, t= - 0.356, although there was a reduction of the E/E' ratio. Conclusion: Tissue Doppler imaging and color M-mode echocardiographic parameters are independent of the intravascular value status. With no change associated with hemodialysis, these parameters can be used as reliable criteria for evaluating ventricular diastolic function even when the volume status varies.     Hekmat R. *1"nTalebi S.2"nMohebati.M.2"n1- Department of Nephrology"n2- Department of Cardiology"nMashad University of Medical"nSciences

Hekmat R

2007-09-01

 
 
 
 
181

Measurement of Blood Pressure Using an Arterial Pulsimeter Equipped with a Hall Device  

Digital Repository Infrastructure Vision for European Research (DRIVER)

To measure precise blood pressure (BP) and pulse rate without using a cuff, we have developed an arterial pulsimeter consisting of a small, portable apparatus incorporating a Hall device. Regression analysis of the pulse wave measured during testing of the arterial pulsimeter was conducted using two equations of the BP algorithm. The estimated values of BP obtained by the cuffless arterial pulsimeter over 5 s were compared with values obtained using electronic or liquid mercury BP meters. The...

Jong-Gu Choi; Keun-Ho Kim; Woo-Beom Lee; Dong-Hyun Nam; Il-Ho Son; You-Sik Hong; Sang-Suk Lee

2011-01-01

182

Ambulatory pulmonary artery pressure monitoring during sleep and exercise in normal individuals and patients with COPD  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Background: Pulmonary hypertension is a common complication of chronic obstructive airways disease (COPD) and its presence implies a poor prognosis. However, it is difficult to measure and its specific contribution to symptoms is difficult to quantify. A micromanometer tipped pulmonary artery catheter was used to measure pulmonary artery pressure (PAP) during sleep and on exercise.

Raeside, D.; Brown, A.; Patel, K.; Welsh, D.; Peacock, A.

2002-01-01

183

Comparative study of changes in arterial pressure and heart rate during dental treatment under local anesthesia in hypertensive patients versus normotensive patients.  

Science.gov (United States)

The aim of this study was to determine changes in arterial pressure (AP) and heart rate (HR) during dental treatment under local infiltration anesthesia (LIA) in patients with controlled arterial hypertension (AHT) versus normotensive patients. A longitudinal comparative study involving repeated measurements in well-controlled hypertensive (cases) and normotensive patients (controls) was conducted. All patients received standardized preventive periodontal treatment under LIA (1.8 ml of 4% articaine with 1:100000 L-Adrenaline). AP and HR were determined at 5 different phases of treatment. The study comprised 82 patients, 46.3% of whom were hypertensive, 61% were female. Systolic (SAP) and diastolic (DAP) arterial pressure and HR increased as the procedure advanced and then returned to initial values in both groups. Average HR values were lower in normotensive than in hypertensive patients (p hypertensive patients. The hypertensive patients tended to develop AHT (> 140/90 mmHg) more frequently throughout the procedure (p = 0.002), SHOWING a 4.93-fold higher risk. Logistic regression analysis showed that sex (p treatment. Controlled hypertensive patients with normal AP values at the onset of dental treatment were found to be at a 5-fold higher risk of developing AHT during the course of dental treatment under local infiltration anesthesia. The observed increases in AP, however, did not reach clinically significant levels. The HR values tended to increase with the progress of dental treatment in all patients. HR was lower in hypertensive patients probably due a drug effect. PMID:23798080

Nicolosi, Liliana; Lewin, Pablo; Winter, Gustavo; Medina, Fabiana; Carballo, Juan; Martinez-, Carlos; Rubio, María

2012-01-01

184

Corticoterapia pré-natal nas síndromes hipertensivas da gestação e seus efeitos na pressão arterial materna Antenatal glucocorticoid therapy and hypertensive pregnancies: effect in maternal blood pressure  

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Full Text Available OBJETIVOS: Avaliar o comportamento da pressão arterial em gestantes portadoras de síndromes hipertensivas na vigência de ciclo de corticóide (esquema de LIGGINS utilizado para a aceleração da maturidade pulmonar fetal. MÉTODOS: A partir de estudo retrospectivo, foram avaliadas 27 gestantes portadoras de hipertensão arterial, com idade gestacional entre 24 e 34 semanas, submetidas a corticoterapia antenatal. Para tanto, foi realizada análise estatística das médias das pressões arteriais sistólicas e diastólicas separadamente, dos dias anterior, primeiro e segundo dias que compõem o ciclo de corticoterapia e do dia posterior a este ciclo. Obtidas as variâncias, foi aplicado o teste F Statistic, analisado através do valor de p, significante, se menor que 0,05. RESULTADOS: Não foi observada variação significativa dos níveis de pressão arterial, seja sistólica como diastólica, não se identificando dificuldades no controle clínico das pacientes, não tendo sido observada necessidade de elevação das doses de drogas hipotensores utilizadas. CONCLUSÃO: Nossos resultados observaram segurança na utilização de ciclos de corticóides em pacientes portadoras de hipertensão arterial em relação à possíveis agravos dos níveis pressóricos.PURPOSE: To evaluate the behaviour of blood pressure among hypertensive pregnants during glucocorticoid therapy (LIGGINS scheme in order to accelerate the maturity of fetal lung. METHODS: In a retrospective study, 27 pregnant with a story of hypertensive disorder, between 24 and 34 weeks, during glucocorticoid cycle were avaluated. For this matter, statistical analisis were performed using the means of systolic (SBP and diastolic blood pressure during the therapy days, on the day before and on the day after. The results were statistically analyzed with F statistic test ( significant if p<005 RESULTS: There was no statistical variance in blood pressure levels, neither in SBP nor in DBP. There was no difficulty in clinical controls and no change in antihypertensive drugs related to glucocorticoid therapy. CONCLUSIONS: Our results show observe the safety of glucocorticoid therapy among pregnant women with hypertensive disorders related to the possible raising of the blood pressure levels.

N. SASS

2001-09-01

185

An Inexpensive Arterial Pressure Wave Sensor and its application in different physiological condition  

CERN Document Server

Arterial Blood Pressure wave monitoring is considered to be important in assessment of cardiovascular system. We developed a novel pulse wave detection system using low frequency specific piezoelectric material as pressure wave sensor. The transducer detects the periodic change in the arterial wall diameter produced by pressure wave and the amplified signal after integration represents the pressure wave. The signal before integration is proportional to the rate of change of pressure wave and it not only reproduces the pressure waveform faithfully, but also its sharper nature helps to reliably detect the heart period variability (HPV). We have studied the position-specific (e.g. over carotid or radial artery) nature of change of this pulse wave signal (shape and amplitude) and also the changes at different physiological states.

Sur, S; Sur, Shantanu

2005-01-01

186

Focus on diastolic dysfunction: A new approach to heart failure therapy  

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1. Although heart failure is commonly associated with depressed systolic function, there is increasing evidence that impaired diastolic performance is also universally present and might be a key determinant of symptoms, physical capacity and even survival in some subsets of patients. 2. Reduced diastolic distensibility increases cardiac filling pressure not only at rest, but even more during exercise when diastolic filling time is reduced. The increases in filling pressure and diastolic wall ...

Pouleur, H.; Hanet, Claude; Gurne?, O.; Rousseau, Michel

1989-01-01

187

Effects of hypoproteinemia on renal hemodynamics, arterial pressure, and fluid volume  

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The effects of long-term hypoproteinemia on renal hemodynamics, arterial pressure, and fluid volume were studied in eight conscious dogs over a 34-day period. Plasma protein concentration (PPC) was decreased by daily plasmapheresis, and the effects of decreasing and increasing sodium intake were measured. By the 12th day of plasmapheresis PPC had decreased to 2.5 g/dl from a control value of 7.2 g/dl, mean arterial pressure had decreased to 78% of control, glomerular filtration rate (GFR) was 75.2% of control, and urinary sodium excretion was decreased. By day 18 of plasmapheresis, estimated renal plasma flow (ERPF) was decreased to 60% of control due to the decreased arterial pressure and an increase in renal vascular resistance. GFR and ERPF were determined from the total clearance of (/sup 125/I)iothalamate and (/sup 131/I)iodohippurate. Also, plasma renin activity and plasma aldosterone concentration were both increased, and the relationship between mean arterial pressure and urinary sodium excretion was distinctly shifted to the left along the arterial pressure axis. In contradistinction to acute experiments, chronic hypoproteinemia results in decreases in GFR, ERPF, and urinary sodium excretion and has marked effects on both fluid volume and arterial pressure regulation.

Manning, R.D. Jr.

1987-01-01

188

Effects of hypoproteinemia on renal hemodynamics, arterial pressure, and fluid volume  

International Nuclear Information System (INIS)

The effects of long-term hypoproteinemia on renal hemodynamics, arterial pressure, and fluid volume were studied in eight conscious dogs over a 34-day period. Plasma protein concentration (PPC) was decreased by daily plasmapheresis, and the effects of decreasing and increasing sodium intake were measured. By the 12th day of plasmapheresis PPC had decreased to 2.5 g/dl from a control value of 7.2 g/dl, mean arterial pressure had decreased to 78% of control, glomerular filtration rate (GFR) was 75.2% of control, and urinary sodium excretion was decreased. By day 18 of plasmapheresis, estimated renal plasma flow (ERPF) was decreased to 60% of control due to the decreased arterial pressure and an increase in renal vascular resistance. GFR and ERPF were determined from the total clearance of [125I]iothalamate and [131I]iodohippurate. Also, plasma renin activity and plasma aldosterone concentration were both increased, and the relationship between mean arterial pressure and urinary sodium excretion was distinctly shifted to the left along the arterial pressure axis. In contradistinction to acute experiments, chronic hypoproteinemia results in decreases in GFR, ERPF, and urinary sodium excretion and has marked effects on both fluid volume and arterial pressure regulation

189

Response of blood pressure after percutaneous transluminal renal artery angioplasty and stenting  

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Full Text Available AIM: To evaluate the short and intermediate term outcome of percutaneous transluminal renal artery angioplasty (PTRA and stenting particularly on blood pressure (BP control and renal function and to evaluate predictors of poor BP response after successful PTRA and stenting. METHODS: We conducted a prospective analysis of all patients who underwent PTRA and stenting in our institute between August 2010 to September 2012. A total number of 86 patients were underwent PTRA and renal stenting. Selective angiography was done to confirm at least 70% angiographic stenosis. The predilatation done except few cases with critical stenosis, direct stenting was done in the rest of cases. All patients received aspirin 325 mg orally, and clopidogrel 300 mg orally within 24 h before the procedure. Heparin was used as the procedural anticoagulant agent. Optimal results with TIMI-III flow obtained in all cases. Following stent placement, aspirin 150 mg orally once daily was continued for a minimum of 12 mo and clopidogrel 75 mg orally once daily for at least 4 wk. The clinical, radiological, electrocardiography, echocardiography and treatment data of all patients were recorded. The BP measurement, serum creatinine and glomerular filtration rate (GFR were recorded before the procedure and 1 and 6 mo after PTRA. RESULTS: A total of 86 patients were included in the study. The mean age of study population was 55.87 ± 11.85 years old and 67 (77.9% of patients were male. There was a significant reduction in both systolic and diastolic BP at 1 mo after the procedure: 170.15 ± 20.10 mmHg vs 146.60 ± 17.32 mmHg and 98.38 ± 10.55 mmHg vs 89.88 ± 9.22 mmHg respectively (P = 0.0000. The reduction in BP was constant throughout the follow-up period and was evident 6 mo after the procedure: 144.23 ± 18.19 and 88.26 ± 9.79 mmHg respectively (P = 0.0000. However, no improvement in renal function was observed at any time during the follow-up period. After multivariate analysis, we found male sex, low GFR (< 60 mL/min and higher baseline mean BP as a poor predictors of successful outcome on BP response after PTRA and stenting. CONCLUSION: The PTRA and stenting can be considered as an effective therapeutic intervention for improving BP control with minimal effect on renal function. The male sex, higher baseline BP and low GFR are associated with poor BP response after successful PTRA and stenting.

Jayesh S Prajapati

2013-01-01

190

Intra-arterial Infusion of Leptin does not Affect Blood Pressure in Salt-loaded Rabbits  

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Full Text Available The aim of this research is to see the effect of intra-arterial infusion of leptin on blood pressure of salt loaded rabbits in vivo. Increased blood pressure was produced in rabbits by giving diets containing 8% sodium chloride for 5 weeks. Leptin in different concentrations was infused intra-arterially into rabbits fed on high salt diets and the response was compared in rabbits fed with low salt diets. High salt diets produced significant increase in blood pressure. In rabbits fed with low salt diet, leptin infused intra-arterially caused an increase in blood pressure while infusion of leptin into rabbits fed with high salt diets does not affect the blood pressure. In conclusion, salt loading to rabbits abolishes the effect of leptin on cardiovascular system. This may indicate that leptin effect on sympathetic activity is altered by high salt diets in these animals.

Mohammad Nidal Khabaz

2010-01-01

191

Clinical observations on the effect of carotid artery occlusion on cerebral blood flow mapped by xenon computed tomography and its correlation with carotid artery back pressure  

International Nuclear Information System (INIS)

Xenon computed tomographic cerebral blood flow mapping was correlated with internal carotid artery stump pressures and clinical neurologic assessment during temporary internal carotid artery occlusion. One hundred fourteen patients with skull base tumors or intracranial aneurysms potentially requiring carotid resection or ligation underwent angiography, xenon CT cerebral blood flow mapping, and internal carotid artery blood pressure monitoring. The internal carotid artery was then temporarily occluded with a balloon catheter, stump pressure was measured through the catheter, and the xenon CT cerebral blood flow mapping was repeated. Adequate xenon CT cerebral blood flow was defined as greater than 30 cc/100 gm/min. All patients had normal xenon CT cerebral blood flow before internal carotid artery occlusion. During internal carotid artery occlusion, xenon CT cerebral blood flow was found to be normal (group I, 40 patients), globally reduced but still within the normal range (group II, 50 patients), or low in the distribution of the ipsilateral middle cerebral artery (group III, 13 patients). With balloon occlusion, an immediate neurologic deficit developed in 11 patients (9%) requiring deflation of the balloon preceding xenon CT cerebral blood flow measurement (group IV). In group I internal carotid artery blood pressure was 128 mm Hg. (range 85 to 171 mm Hg) with stump pressure 86 mm Hg (range 46 to 125 mm Hg). In group II internal carotid artery blood pressure was 130 mm Hg. (range 78 to 199 mm Hg), with stump pressure 86 mm Hg (range 31 to 150 mm Hg)

192

Construcción y validación clínica de un prototipo para el registro continuo de la presión arterial de forma no invasiva y ambulatoria / Construction and clinical validation of an automated measuring device for continuous non-invasive ambulatory blood pressure measurement  

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Full Text Available SciELO Colombia | Language: Spanish Abstract in spanish Introducción: la monitorización ambulatoria de la presión arterial con equipos biomédicos, es un método útil y confiable para el diagnóstico de la hipertensión arterial. El propósito del estudio fue validar un nuevo equipo de monitorización ambulatoria de la presión arterial de 24 horas (MAPA-FCV) d [...] e bajo costo, producido en la Fundación Cardiovascular de Colombia. Métodos: el estudio se desarrolló de acuerdo con las recomendaciones de la Sociedad Americana para el Avance de la Instrumentación Médica (AAMI, por sus siglas en Inglés) y la Sociedad Británica de Hipertensión (BHS) para validación de equipos de monitorización de presión arterial. Se incluyeron 85 sujetos sanos, en quienes, una persona previamente entrenada, obtuvo tres medidas simultáneas de presión arterial (cada 10 minutos) y se compararon con las que se obtuvieron con el equipo MAPA-FCV. Resultados: los sujetos presentaron una presión arterial sistólica de 115 ± 15 mm Hg y diastólica de 71 ± 8 mm Hg. Se encontró una diferencia media de 0,63 ± 5,94 mm Hg en la presión arterial sistólica y de 0,17 ± 5,08 mm Hg en la diastólica entre el equipo y el observador entrenado. Así mismo, se observó que más de 93% de las mediciones simultáneas de presión arterial, presentaron una diferencia menor a 10 mm Hg. Conclusiones: en el estudio el monitor MAPA-FCV alcanzó altos grados de concordancia con los valores de presión arterial que obtuvo el personal capacitado; adicionalmente el equipo cumplió con los criterios de validación de la AAMI y BHS, lo que hace posible su recomendación para uso clínico en población adulta. Abstract in english Introduction: ambulatory arterial pressure monitoring with biomedical devices is a useful and reliable method to diagnose hypertension. The aim of this study was to validate a new low cost Holter blood pressure monitor (MAPA-FCV) produced at the Fundación Cardiovascular de Colombia. Methods: the stu [...] dy was developed according to the guidelines for validation of automated blood pressure measuring devices of the Association for the Advancement of Medical Instrumentation (AAMI) and the British Hypertension Society (BHS). Three blood pressure measurements were taken in 85 healthy subjects in a 30 minutes period (every 10 minutes). Measurements were taken by one observer trained to measure blood pressure with a mercury column device, and were compared with those obtained with the automatic device. Results: mean systolic blood pressure obtained in the subjects was 115 ± 15 mmHg, and mean diastolic blood pressure was 71 ± 8 mmHg. The mean and standard deviation of the differences between the measurements obtained by the observer and those obtained with the automatic device were 0.63 ± 5.94 mmHg for systolic pressure and 0.17 ± 5.08 mmHg for diastolic pressure. In addition, about 93% of the differences between the ascultatory and MAPA-FCV were within 10 mmHg. Conclusions: in the present study a close agreement between systolic and diastolic pressure measurements obtained by the auscultatory method and the MAPA-FCV device was found. The data obtained show that the MAPA-FCV can be recommended for clinical use according to the guidelines of international entities.

Ángel M, Chaves; Ronald G, García; Wilson, Gamboa; Leonardo, Rodríguez; Isabel C, Arenas; Hernán, Villa-Roel; Víctor R, Castillo.

2009-02-01

193

Pressão arterial após programa de exercício físico supervisionado em mulheres idosas hipertensas / Blood pressure after supervised physical exercise program in elderly women with hypertension  

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Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese INTRODUÇÃO: A população de idosos tem elevado os índices de doenças crônicas como hipertensão arterial sistêmica (HAS) com prevalência em mulheres. Intervenções não farmacológicas, como o exercício físico, são apontadas pela eficácia na diminuição da pressão arterial (PA). OBJETIVO: Verificar a resp [...] osta da pressão arterial de idosas hipertensas nos distintos momentos de um programa de exercício físico supervisionado (PEFS). MÉTODOS: Constituiu-se de um estudo descritivo de corte transversal realizado durante 18 semanas. Participaram 41 mulheres idosas com HAS, em tratamento farmacológico, distribuídas em grupo experimental (GE) (n = 26) que participou da intervenção, e grupo controle (GC) (n = 15), em dois momentos: pré e pós-PEFS. O IMC, a pressão arterial sistólica (PAS) e diastólica (PAD) foram avaliados no início e após 18 semanas de PEFS no GE e GC. A comparação intra e intergrupos foi feita com o teste t pareado e ANOVA two way com Kruskal Wallis, com nível de significância de p Abstract in english INTRODUCTION: The elderly population has increased the levels of chronic diseases such as hypertension (HBP) with prevalence in women. Non-pharmacological interventions, such as exercise, have been indicated by the effectiveness in lowering blood pressure (BP). OBJECTIVE: To analyze the blood pressu [...] re response in elderly hypertensive women in the different moments of a supervised physical exercise program (SPEP). METHODS: It consisted of a cross-sectional descriptive study carried out for 18 weeks. 41 elderly women with hypertension, under pharmacological treatment, distributed in the experimental group (EG) (n=26) which participated in the intervention, and control group (CG) (n=15) in two stages: before and after SPEP. BMI, systolic blood pressure (SBP) and diastolic blood pressure (DBP) were evaluated at baseline and after 18 weeks of SPEP in the EG and CG. The intra and inter comparison was made with the paired t test and two-way ANOVA with Kruskal Wallis test, with a significance level of p

Adriana Ribeiro de O. N. do, Rêgo; André L. M., Gomes; Renato P., Veras; Edmundo de Drummond, A. Júnior; Rodolfo Alkimin, M.N.; Estélio H. M., Dantas.

194

Cone pathway function in relation to asymmetric carotid artery stenosis : correlation to blood pressure  

DEFF Research Database (Denmark)

Purpose:  To examine retinal function in relation to retinal perfusion pressure in patients with carotid artery stenosis. Methods:  Thirteen patients with carotid artery stenosis without clinical eye disease underwent assessment of ophthalmic artery systolic blood pressure (OSP) by ocular pneumoplethysmography, carotid artery obstructive disease by ultrasonography, intraocular pressure by applanation tonometry, retinal perfusion by fluorescein angiography and retinal function by multifocal electroretinography (mfERG). Data analysis compared the eye on the most stenotic side with the fellow eye in the same patient. Results:  Ophthalmic systolic pressure was 95.8?±?13.1?mmHg on the side with the highest degree of carotid artery stenosis (mean 94.0%) and 111.7?±?10.3?mmHg in the fellow eyes on the side with the lesser degree of stenosis (mean 33.9%). Summed mfERG implicit times (N1 and P1) were 3.4% and 2.0% longer (p?=?0.013 and 0.021), and N1 and P1 amplitudes were 18.0% and 16.0% (p?=?0.0041 and 0.020) lower in eyes on the side with the higher stenosis compared with the contralateral eyes. Shorter implicit times and higher amplitudes were correlated with higher brachial systolic arterial blood pressure (p?=?0.0028, 0.011, 0.041 for N1, P1, N2 implicit times, respectively, and p?=?0.0086, 0.016, 0.040 for N1, P1, N2 for amplitudes, respectively, corrected for OSP). Conclusion:  Cone function deviation was observed in clinically healthy eyes on the side with highest degree of carotid artery stenosis and was found correlated to arterial blood pressure.

Kofoed, Peter Kristian; Munch, Inger Christine

2013-01-01

195

Evaluation of diastolic function in patients with slow coronary flow by conventional and tissue Doppler echocardiography  

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Full Text Available Objective: In present study, we aimed to investigate the effect of slow coronary flow (SCF on left ventricular diastolic functions by using conventional and tissue Doppler imaging method. Methods: Thirty-two SCF patients with normal coronary artery (mean age, 55±13, 18 male, and 30 normal coronary flow patients with normal coronary artery (mean age, 50±10, 15 male were enrolled to the study. TIMI frame count method was used for SCF diagnosis. The left ventricular diastolic functions of all participants were evaluated by conventional and tissue Doppler echocardiography one day after coronary angiography. All data were compared between two groups. Results: TIMI frame counts of left anterior descending artery, circumflex and right coronary artery were significantly higher in CSF group (p<0.01. There were significant decrease in early and late diastolic maximum filling rates (E/A (p<0.01, and significant prolongation at early deceleration time (p<0.01 on conventional echocardiography in CSF group. The tissue Doppler parameters which have been measured from the four region of mitral annulus were as follows: the mean Em velocity and mean Em/Am ratio were significantly lower in CSF patients (p<0.01, and mean Am velocity were significantly higher (p<0.01. E/Em, a non-invasive predictor of left ventricular filling pressures, is similar in both groups. Conclusion: The regional and global left ventricular functions of SCF patients were significantly deteriorated compared to controls. J Clin Exp Invest 2014; 5 (2: 443-446

Arif Süner

2014-06-01

196

Effects of glitazones on blood pressure and vascular structure in mesenteric resistance arteries and basilar artery from genetically hypertensive rats.  

Science.gov (United States)

1. The effects of two of the glitazone (thiazolidinedione) class of drugs, namely rosiglitazone and pioglitazone, on blood pressure and vascular remodelling in the New Zealand genetically hypertensive (GH) rat model were investigated. 2. In the first study, a GH group given rosiglitazone (5 mg/kg per day) from the age of 7 to 12 weeks was compared with a GH control group. In the second study, GH rats were given either pioglitazone, simvastatin, valsartan or combinations of pioglitazone with simvastatin or valsartan (all drugs at a dose of 10 mg/kg per day). 3. Tail-cuff systolic blood pressure was measured weekly. At the end of the experiment, blood vessels were fixed by perfusion and samples of mesenteric resistance arteries (MRA), second-order branches and basilar artery were embedded in Technovit and serial sections were cut and stained with Giemsa for stereological analysis. Media width, medial cross-sectional area and lumen diameter were determined and the ratio of media width/lumen diameter was calculated. 4. Rosiglitazone significantly reduced blood pressure in GH rats. 5. In MRA, rosiglitazone had a hypotrophic effect on media, reduced lumen diameter and reduced media/lumen ratio (P<0.001). 6. In basilar artery, there was also a hypotrophic effect of rosiglitazone on media and reduced media/lumen ratio (P<0.001). 7. Pioglitazone slowed down the rate of blood pressure increase with age in GH rats and had a greater effect on blood pressure when given in combination with simvastatin. 8. Pioglitazone had a hypotrophic effect on the media of MRA and basilar artery. The hypotrophic effect was enhanced when pioglitazone was given in combination with simvastatin. The media/lumen ratio was reduced by pioglitazone; in MRA, combination treatment with simvastatin reduced the ratio further to normal and, with valsartan, to below normal. In basilar artery, the media/lumen ratio was reduced further by both combination treatments, but was lowest in the pioglitazone-valsartan combination group. 9. The significant effects on MRA and basilar artery structure (and, thus, haemodynamics) seen after rosiglitazone monotherapy and after pioglitazone, given alone and in combination with simvastatin or valsartan, may well indicate a glitazone class effect on vascular structure and, hence, cardiovascular function. PMID:16405447

Ledingham, Janet M; Laverty, Richard

2005-11-01

197

Assessment of the changes in blood pressure circadian profile and variability in patients with chronic heart failure and arterial hypertension during combined therapy including ivabradine  

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Full Text Available Aim. To assess the changes in blood pressure (BP circadian profile and variability in patients with chronic heart failure (CHF of ischemic etiology and arterial hypertension (HT due to the complex therapy including ivabradine.Material and methods. Patients (n=90 with CHF class II–III NYHA associated with stable angina II-III class and HT were examined. The patients were randomized into 3 groups depending on received drugs: perindopril and ivabradine - group 1; perindopril, bisoprolol and ivabradine - group 2; perindopril and bisoprolol - group 3. The duration of therapy was 6 months. Ambulatory BP monitoring (ABPM was assessed at baseline and after treatment.Results. More significant reduction in average 24-hours systolic BP was found in groups 1 and 2 compared to group 3 (?%: -19.4±0,4; -21.1±0.4 and -11.8±0.6, respectively as well as diastolic BP (?%: -10.6±0.6; -12.9±0.4 and -4,3±0.3, respectively and other ABPM indicators. Improvement of BP circadian rhythm was found due to increase in the number of «Dipper» patients (p=0.016. More significant reduction in average daily and night systolic and diastolic BP (p=0.001, as well as daily and night BP variability (p=0.001 was also found in patients of group 2 compared to these of group 1.Conclusion. Moderate antihypertensive effect (in respect of both diastolic and systolic BP was shown when ivabradine was included into the complex therapy of patients with ischemic CHF and HT. The effect was more pronounced when ivabradine was combined with perindopril and bisoprolol. This was accompanied by reduction in high BP daily variability and improvement of the BP circadian rhythm.

M.V. Surovtseva

2012-10-01

198

Calculating arterial pressure-based cardiac output using a novel measurement and analysis method.  

Science.gov (United States)

Work on applying physical and physiological principles for determining cardiac output by analysis of pressure measurements has been pursued for decades. Reference measurements for this kind of cardiac output analysis rely on the pulmonary artery catheter (PAC), considered the clinical gold standard for cardiac output monitoring. Recent advances in signal processing, as well as applied information on the relationships that enable arterial pulse pressure to be used to determine stroke volume, have led to the development of a novel system that can continuously measure cardiac output from an arterial pressure waveform that does not require an external calibration reference method. There are significant challenges in applying statistical- and signal-processing practices to the analysis of complex physiological waveforms. This paper reviews the historical basis for measuring flow from the analysis of pressure in a vessel, establishes the physiological and mathematical basis for this new system and describes its performance under various physiological conditions. PMID:17992808

Pratt, Benjamin; Roteliuk, Luchy; Hatib, Feras; Frazier, John; Wallen, Roy D

2007-01-01

199

Prevalência de pressão arterial elevada em escolares e adolescentes de Maceió / Prevalence of high blood pressure in children and adolescents from the city of Maceió, Brazil  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese OBJETIVOS: Definir a prevalência de pressão arterial elevada em amostra representativa de escolares e adolescentes de Maceió (Alagoas, Brasil) e pesquisar a associação de pressão arterial elevada com idade, gênero e estado nutricional. MÉTODOS: Estudo epidemiológico descritivo, transversal, randomiz [...] ado, realizado entre maio de 2000 e setembro de 2002, que avaliou indivíduos de 7 a 17 anos sorteados entre 185.702 alunos de escolas públicas e privadas de Maceió. O cálculo da amostra foi realizado com base no valor esperado da prevalência de hipertensão arterial sistêmica para a faixa etária. Após a randomização, os dados foram coletados através de questionário, aferição de peso e altura e duas medidas da pressão arterial. Pressão arterial elevada foi definida como pressão arterial sistólica e/ou diastólica igual ou acima do percentil 95 em qualquer das duas medidas realizadas. RESULTADOS: A amostra final constituiu-se de 1.253 estudantes (706 do gênero feminino). Foram identificados 118 estudantes com pressão arterial elevada, média de idade de 13 anos, sendo 44% do gênero masculino. Risco de sobrepeso foi identificado em 9,3% das crianças, e sobrepeso, em 4,5%; houve associação significante dessas variáveis com pressão arterial elevada. CONCLUSÕES: A prevalência de pressão arterial elevada foi de 9,4%, e foi significantemente maior nos estudantes com sobrepeso e com risco de sobrepeso. Abstract in english OBJECTIVES: To define the prevalence of high blood pressure in a representative sample of children and adolescents from the city of Maceió, state of Alagoas, Brazil, and to investigate the association of high blood pressure with age, sex and nutritional status. METHODS: This cross-sectional study wa [...] s carried out from May 2000 to September 2002. Individuals between 7 and 17 years of age were selected among all the 185,702 students from public and private schools. The size of the sample was defined based on the expected prevalence of hypertension for the age group. After randomization, data were collected through a questionnaire. Blood pressure was measured twice. Weight and height were also measured. High blood pressure was defined as systolic and/or diastolic blood pressure over the 95th percentile in one or in both measures. RESULTS: The final sample included 1,253 students (706 females). One hundred and eighteen students had high blood pressure (mean age 13 years; 44% males). Risk of being overweight and excess weight were identified, respectively, in 9.3 and 4.5% of the students. These variables were significantly associated with high blood pressure. CONCLUSIONS: The prevalence of high blood pressure was 9.4%. High blood pressure was significantly more frequent among overweight students and among those at risk for being overweight.

Adriana A, Moura; Maria A. M, Silva; Maria R. M. T, Ferraz; Ivan R, Rivera.

200

Research on the Time-Dependent Adaptation of Arterial Blood Pressure Considering Load Value  

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Full Text Available The article analyses the time-dependent adaptation of arterial blood pressure with reference to load value, age and gender. Three male and female groups of different age were investigated applying load from 50 W to 150 W. Veloergometer “Kettler” and computerized “Siemens” and SpaceLabs Medical” data recording systems were used during investigation. Variations in arterial blood pressure having established load within changing time period were recorded. It was discovered that along with changes in load from 50 W to 150 W, arterial blood pressure in male groups of different age increased approximately 1,2 times and adaptation time prolonged 2,9 times. In female groups of different age, arterial blood pressure increased approximately 1,3 times and adaptation time prolonged 2,6 times. It was acknowledged that the longer was adaptation time and the larger was an increase in arterial blood pressure, the more complicated was adaptation to the load.Article in Lithuanian

Me?islovas Mari?nas

2011-02-01

 
 
 
 
201

The area of the pressure-flow loop for assessment of arterial stenosis: a new index.  

Science.gov (United States)

This study describes a novel method for assessing stenotic severity, based on simultaneous pressure and flow wave measurements. Pressure and flow measurements were performed in latex and rubber tubes, and in a clinically-used vascular graft. Pressure waves were recorded at several degrees of stenosis and at different distances proximal to the stenosis. Pressure wave versus flow wave was plotted. Internal pressure-flow loop area (PFLA), loop slope and pressure-axis intercept were calculated. Values of these three indices significantly increased with increasing degrees of stenosis P functions were fitted, resulting in an excellent PFLA variable/ percent stenosis correlation, independent of distance between sensor and stenosis (R2 > 0.96). In addition, tube compliance was measured and found to correlate with the polynomial coefficients (/R/ > 0.9). This innovative approach could significantly contribute to detecting and evaluating arterial stenoses, and to characterize the elasticity of the artery. PMID:11847447

Ovadia-Blechman, Zehava; Einav, Shmuel; Zaretsky, Uri; Castel, David; Toledo, Eran; Eldar, Michael

2002-01-01

202

Corticoterapia pré-natal nas síndromes hipertensivas da gestação e seus efeitos na pressão arterial materna / Antenatal glucocorticoid therapy and hypertensive pregnancies: effect in maternal blood pressure  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese OBJETIVOS: Avaliar o comportamento da pressão arterial em gestantes portadoras de síndromes hipertensivas na vigência de ciclo de corticóide (esquema de LIGGINS) utilizado para a aceleração da maturidade pulmonar fetal. MÉTODOS: A partir de estudo retrospectivo, foram avaliadas 27 gestantes portador [...] as de hipertensão arterial, com idade gestacional entre 24 e 34 semanas, submetidas a corticoterapia antenatal. Para tanto, foi realizada análise estatística das médias das pressões arteriais sistólicas e diastólicas separadamente, dos dias anterior, primeiro e segundo dias que compõem o ciclo de corticoterapia e do dia posterior a este ciclo. Obtidas as variâncias, foi aplicado o teste F Statistic, analisado através do valor de p, significante, se menor que 0,05. RESULTADOS: Não foi observada variação significativa dos níveis de pressão arterial, seja sistólica como diastólica, não se identificando dificuldades no controle clínico das pacientes, não tendo sido observada necessidade de elevação das doses de drogas hipotensores utilizadas. CONCLUSÃO: Nossos resultados observaram segurança na utilização de ciclos de corticóides em pacientes portadoras de hipertensão arterial em relação à possíveis agravos dos níveis pressóricos. Abstract in english PURPOSE: To evaluate the behaviour of blood pressure among hypertensive pregnants during glucocorticoid therapy (LIGGINS scheme) in order to accelerate the maturity of fetal lung. METHODS: In a retrospective study, 27 pregnant with a story of hypertensive disorder, between 24 and 34 weeks, during gl [...] ucocorticoid cycle were avaluated. For this matter, statistical analisis were performed using the means of systolic (SBP) and diastolic blood pressure during the therapy days, on the day before and on the day after. The results were statistically analyzed with F statistic test ( significant if p

N., SASS; R.R., CANÇADO; M.L., OLIVEIRA; M.R., TORLONI.

203

Corticoterapia pré-natal nas síndromes hipertensivas da gestação e seus efeitos na pressão arterial materna / Antenatal glucocorticoid therapy and hypertensive pregnancies: effect in maternal blood pressure  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese OBJETIVOS: Avaliar o comportamento da pressão arterial em gestantes portadoras de síndromes hipertensivas na vigência de ciclo de corticóide (esquema de LIGGINS) utilizado para a aceleração da maturidade pulmonar fetal. MÉTODOS: A partir de estudo retrospectivo, foram avaliadas 27 gestantes portador [...] as de hipertensão arterial, com idade gestacional entre 24 e 34 semanas, submetidas a corticoterapia antenatal. Para tanto, foi realizada análise estatística das médias das pressões arteriais sistólicas e diastólicas separadamente, dos dias anterior, primeiro e segundo dias que compõem o ciclo de corticoterapia e do dia posterior a este ciclo. Obtidas as variâncias, foi aplicado o teste F Statistic, analisado através do valor de p, significante, se menor que 0,05. RESULTADOS: Não foi observada variação significativa dos níveis de pressão arterial, seja sistólica como diastólica, não se identificando dificuldades no controle clínico das pacientes, não tendo sido observada necessidade de elevação das doses de drogas hipotensores utilizadas. CONCLUSÃO: Nossos resultados observaram segurança na utilização de ciclos de corticóides em pacientes portadoras de hipertensão arterial em relação à possíveis agravos dos níveis pressóricos. Abstract in english PURPOSE: To evaluate the behaviour of blood pressure among hypertensive pregnants during glucocorticoid therapy (LIGGINS scheme) in order to accelerate the maturity of fetal lung. METHODS: In a retrospective study, 27 pregnant with a story of hypertensive disorder, between 24 and 34 weeks, during gl [...] ucocorticoid cycle were avaluated. For this matter, statistical analisis were performed using the means of systolic (SBP) and diastolic blood pressure during the therapy days, on the day before and on the day after. The results were statistically analyzed with F statistic test ( significant if p

N., SASS; R.R., CANÇADO; M.L., OLIVEIRA; M.R., TORLONI.

2001-09-01

204

Understanding the contribution of Guyton's large circulatory model to long-term control of arterial pressure  

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With the publication in 1972 of a large computer model of circulatory control, Guyton and colleagues challenged the then prevailing views on how blood pressure and cardiac output were controlled. At that time, it was widely accepted that the heart controlled cardiac output and that peripheral resistance controlled arterial blood pressure. By incorporating the empirically demonstrated concepts of blood flow autoregulation and the pressure–natriuresis relationship into their mathematical mode...

Montani, Jean-pierre; Vliet, Bruce N.

2009-01-01

205

Pressão arterial elevada em adolescentes: prevalência e fatores associados / High blood pressure in adolescents: prevalence and associated factors  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese Objetivou-se verificar a prevalência e os fatores associados à pressão arterial (PA) elevada em adolescentes de um município Brasileiro. Estudo transversal, conduzido em 653 adolescentes (57,9% do sexo feminino) de 14 a 19 anos de idade, estudantes do ensino médio. A Pressão arterial sistólica (PAS) [...] e a diastólica (PAD) foram mensuradas em todos os sujeitos. Variáveis sociodemográficas, do estilo de vida e índice de massa corporal foram obtidas. Regressão logística binária, bruta e ajustada, foi empregada com nível de significância de 5%. A média da PAS e PAD foi de 111,9 mmHg e 69,9 mmHg, respectivamente. A prevalência de PA elevada foi de 12,4%. Na análise multivariável foi identificado que jovens do sexo masculino (OR: 2,37; IC95%: 1,45-3,90), com escolaridade materna de até oito anos (OR: 1,84; IC95%: 1,03-3,30) e com excesso de peso (OR: 3,79; IC95%: 2,23-6,43), apresentaram maiores chances de PA elevada. O termo de interação entre sexo masculino e excesso de peso representou o subgrupo com maiores chances de PA elevada (OR: 6,41; IC95%: 3,00-13,16). Níveis pressóricos elevados acometem adolescentes da cidade de Ponta Grossa, Paraná, e os grupos com maiores chances de PA elevada foram os do sexo masculino, com escolaridade materna baixa e com excesso de peso. Abstract in english The aim of this study was to assess the prevalence and associated factors of high Blood Pressure (BP) among adolescents in a Brazilian city. A cross-sectional study was conducted with 653 adolescents (57.9% female) of high school level between 14 and 19 years of age. Systolic blood pressure (SBP) an [...] d diastolic blood pressure (DBP) of all subjects were measured. Social and demographic variables and lifestyle factors and body mass index were obtained. Binary logistic regression, crude and adjusted, was employed with a significance level of 5%. The mean SBP and DBP were 111.9 mmHg and 69.9 mmHg, respectively. The prevalence of high BP levels was 12.4%. The multivariable analysis revealed that males (OR: 2.37, 95% CI: 1.45, 3.90), adolescents with maternal education

Diego Augusto Santos, Silva; Luiz Rodrigo Augustemak de, Lima; Rodolfo André, Dellagrana; Eliane Denise Araújo, Bacil; Cassiano Ricardo, Rech.

206

Pressão arterial elevada em adolescentes: prevalência e fatores associados / High blood pressure in adolescents: prevalence and associated factors  

Scientific Electronic Library Online (English)

Full Text Available SciELO Public Health | Language: Portuguese Abstract in portuguese Objetivou-se verificar a prevalência e os fatores associados à pressão arterial (PA) elevada em adolescentes de um município Brasileiro. Estudo transversal, conduzido em 653 adolescentes (57,9% do sexo feminino) de 14 a 19 anos de idade, estudantes do ensino médio. A Pressão arterial sistólica (PAS) [...] e a diastólica (PAD) foram mensuradas em todos os sujeitos. Variáveis sociodemográficas, do estilo de vida e índice de massa corporal foram obtidas. Regressão logística binária, bruta e ajustada, foi empregada com nível de significância de 5%. A média da PAS e PAD foi de 111,9 mmHg e 69,9 mmHg, respectivamente. A prevalência de PA elevada foi de 12,4%. Na análise multivariável foi identificado que jovens do sexo masculino (OR: 2,37; IC95%: 1,45-3,90), com escolaridade materna de até oito anos (OR: 1,84; IC95%: 1,03-3,30) e com excesso de peso (OR: 3,79; IC95%: 2,23-6,43), apresentaram maiores chances de PA elevada. O termo de interação entre sexo masculino e excesso de peso representou o subgrupo com maiores chances de PA elevada (OR: 6,41; IC95%: 3,00-13,16). Níveis pressóricos elevados acometem adolescentes da cidade de Ponta Grossa, Paraná, e os grupos com maiores chances de PA elevada foram os do sexo masculino, com escolaridade materna baixa e com excesso de peso. Abstract in english The aim of this study was to assess the prevalence and associated factors of high Blood Pressure (BP) among adolescents in a Brazilian city. A cross-sectional study was conducted with 653 adolescents (57.9% female) of high school level between 14 and 19 years of age. Systolic blood pressure (SBP) an [...] d diastolic blood pressure (DBP) of all subjects were measured. Social and demographic variables and lifestyle factors and body mass index were obtained. Binary logistic regression, crude and adjusted, was employed with a significance level of 5%. The mean SBP and DBP were 111.9 mmHg and 69.9 mmHg, respectively. The prevalence of high BP levels was 12.4%. The multivariable analysis revealed that males (OR: 2.37, 95% CI: 1.45, 3.90), adolescents with maternal education

Diego Augusto Santos, Silva; Luiz Rodrigo Augustemak de, Lima; Rodolfo André, Dellagrana; Eliane Denise Araújo, Bacil; Cassiano Ricardo, Rech.

207

Arterial mechanical properties in dilated cardiomyopathy. Aging and the response to nitroprusside.  

Digital Repository Infrastructure Vision for European Research (DRIVER)

The effects of aging on arterial mechanical properties and the response to nitroprusside were examined in 25 patients with dilated cardiomyopathy. High-fidelity pressures were recorded with a multisensor catheter. Pulse wave velocity was determined between two sensors in the thoracic aorta. Arterial compliance was determined by an analysis of the diastolic waveform and cardiac output. At baseline, despite a similar systemic vascular resistance, the pulsatile load (e.g., arterial compliance) a...

Carroll, J. D.; Shroff, S.; Wirth, P.; Halsted, M.; Rajfer, S. I.

1991-01-01

208

Velocidade da onda de pulso, pressão arterial e adipocitocinas em adultos jovens: estudo do Rio de Janeiro Pulse wave velocity, blood pressure and adipocytokines in young adults: the Rio de Janeiro study  

Directory of Open Access Journals (Sweden)

Full Text Available FUNDAMENTO: Dados sobre a avaliação não invasiva vascular e suas relações com variáveis de risco cardiovascular são escassos em jovens. OBJETIVO: Avaliar a relação entre a velocidade de onda de pulso e a pressão arterial,variáveis antropométricas e metabólicas, incluindo as adipocitocinas, em indivíduos adultos jovens. MÉTODOS: Foram avaliados 96 indivíduos (51 homens do estudo do Rio de Janeiro, de 26 a 35 anos (média 30,09 ± 1,92. Foram obtidos a velocidade de onda de pulso (método Complior, pressão arterial, índice de massa corporal, glicose, perfil lipídico, leptina, insulina, adiponectina e o índice de resistência à insulina HOMA-IR. Os indivíduos foram estratificados em três grupos segundo o tercil da VOP para cada sexo. RESULTADOS: O grupo com maior tercil de VOP mostrou maiores médias de pressão arterial sistólica, pressão arterial diastólica, pressão arterial média, índice de massa corporal, insulina, HOMA-IR e menores médias de adiponectina, além de maiores prevalências de diabetes mellitus/intolerância à glicose e hiperinsulinemia. Houve correlação significativa e positiva da velocidade da onda de pulso com pressão arterial sistólica, pressão arterial diastólica, pressão de pulso e pressão arterial média, índice de massa corporal, e LDL-colesterol e negativa com HDL-colesterol e adiponectina. Em modelo de regressão múltipla, após ajuste do HDL-colesterol, LDL-colesterol e adiponectina para sexo, idade, índice de massa corporal e pressão arterial média, apenas o sexo masculino e a pressão arterial média mantiveram correlação significativa com a velocidade de onda de pulso. CONCLUSÃO: A velocidade de onda de pulso em adultos jovens mostrou relação significativa com variáveis de risco cardiovascular, destacando-se o sexo masculino e a pressão arterial média como importantes variáveis no seu determinismo. Os achados sugerem que a medida da VOP pode ser útil para a identificação do acometimento vascular nessa faixa etária.BACKGROUND: Data on noninvasive vascular assessment and their association with cardiovascular risk variables are scarce in young individuals. OBJECTIVE: To evaluate the association between pulse wave velocity and blood pressure, anthropometric and metabolic variables, including adipocytokines, in young adults. METHODS: A total of 96 individuals aged 26 to 35 years (mean 30.09 ± 1.92; 51 males were assessed in the Rio de Janeiro study. Pulse wave velocity (Complior method, blood pressure, body mass index, glucose, lipid profile, leptin, insulin, adiponectin and insulin resistance index (HOMA-IR were analyzed. Subjects were stratified into three groups according to the PWV tertile for each gender. RESULTS: The group with the highest pulse wave velocity (PWV tertile showed higher mean systolic and diastolic blood pressure, mean blood pressure, body mass index, insulin, and HOMA-IR, as well as lower mean adiponectin; higher prevalence of diabetes mellitus/glucose intolerance and hyperinsulinemia. There was a significant positive correlation of PWV with systolic blood pressure, diastolic blood pressure, pulse pressure and mean blood pressure, body mass index, and LDL-cholesterol, and a negative correlation with HDL-cholesterol and adiponectin. In the multiple regression model, after adjustment of HDL-cholesterol, LDL-cholesterol and adiponectin for gender, age, body mass index and mean blood pressure, only the male gender and mean blood pressure remained significantly correlated with PWV. CONCLUSION: PWV in young adults showed a significant association with cardiovascular risk variables, especially in the male gender, and mean blood pressure as important determinant variables. The findings suggest that PWV measurement can be useful for the identification of vascular impairment in this age group.

Oswaldo Luiz Pizzi

2013-01-01

209

Velocidade da onda de pulso, pressão arterial e adipocitocinas em adultos jovens: estudo do Rio de Janeiro Pulse wave velocity, blood pressure and adipocytokines in young adults: the Rio de Janeiro study  

Directory of Open Access Journals (Sweden)

Full Text Available FUNDAMENTO: Dados sobre a avaliação não invasiva vascular e suas relações com variáveis de risco cardiovascular são escassos em jovens. OBJETIVO: Avaliar a relação entre a velocidade de onda de pulso e a pressão arterial,variáveis antropométricas e metabólicas, incluindo as adipocitocinas, em indivíduos adultos jovens. MÉTODOS: Foram avaliados 96 indivíduos (51 homens do estudo do Rio de Janeiro, de 26 a 35 anos (média 30,09 ± 1,92. Foram obtidos a velocidade de onda de pulso (método Complior, pressão arterial, índice de massa corporal, glicose, perfil lipídico, leptina, insulina, adiponectina e o índice de resistência à insulina HOMA-IR. Os indivíduos foram estratificados em três grupos segundo o tercil da VOP para cada sexo. RESULTADOS: O grupo com maior tercil de VOP mostrou maiores médias de pressão arterial sistólica, pressão arterial diastólica, pressão arterial média, índice de massa corporal, insulina, HOMA-IR e menores médias de adiponectina, além de maiores prevalências de diabetes mellitus/intolerância à glicose e hiperinsulinemia. Houve correlação significativa e positiva da velocidade da onda de pulso com pressão arterial sistólica, pressão arterial diastólica, pressão de pulso e pressão arterial média, índice de massa corporal, e LDL-colesterol e negativa com HDL-colesterol e adiponectina. Em modelo de regressão múltipla, após ajuste do HDL-colesterol, LDL-colesterol e adiponectina para sexo, idade, índice de massa corporal e pressão arterial média, apenas o sexo masculino e a pressão arterial média mantiveram correlação significativa com a velocidade de onda de pulso. CONCLUSÃO: A velocidade de onda de pulso em adultos jovens mostrou relação significativa com variáveis de risco cardiovascular, destacando-se o sexo masculino e a pressão arterial média como importantes variáveis no seu determinismo. Os achados sugerem que a medida da VOP pode ser útil para a identificação do acometimento vascular nessa faixa etária.BACKGROUND: Data on noninvasive vascular assessment and their association with cardiovascular risk variables are scarce in young individuals. OBJECTIVE: To evaluate the association between pulse wave velocity and blood pressure, anthropometric and metabolic variables, including adipocytokines, in young adults. METHODS: A total of 96 individuals aged 26 to 35 years (mean 30.09 ± 1.92; 51 males were assessed in the Rio de Janeiro study. Pulse wave velocity (Complior method, blood pressure, body mass index, glucose, lipid profile, leptin, insulin, adiponectin and insulin resistance index (HOMA-IR were analyzed. Subjects were stratified into three groups according to the PWV tertile for each gender. RESULTS: The group with the highest pulse wave velocity (PWV tertile showed higher mean systolic and diastolic blood pressure, mean blood pressure, body mass index, insulin, and HOMA-IR, as well as lower mean adiponectin; higher prevalence of diabetes mellitus/glucose intolerance and hyperinsulinemia. There was a significant positive correlation of PWV with systolic blood pressure, diastolic blood pressure, pulse pressure and mean blood pressure, body mass index, and LDL-cholesterol, and a negative correlation with HDL-cholesterol and adiponectin. In the multiple regression model, after adjustment of HDL-cholesterol, LDL-cholesterol and adiponectin for gender, age, body mass index and mean blood pressure, only the male gender and mean blood pressure remained significantly correlated with PWV. CONCLUSION: PWV in young adults showed a significant association with cardiovascular risk variables, especially in the male gender, and mean blood pressure as important determinant variables. The findings suggest that PWV measurement can be useful for the identification of vascular impairment in this age group.

Oswaldo Luiz Pizzi

2012-01-01

210

Velocidade da onda de pulso, pressão arterial e adipocitocinas em adultos jovens: estudo do Rio de Janeiro / Pulse wave velocity, blood pressure and adipocytokines in young adults: the Rio de Janeiro study  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese FUNDAMENTO: Dados sobre a avaliação não invasiva vascular e suas relações com variáveis de risco cardiovascular são escassos em jovens. OBJETIVO: Avaliar a relação entre a velocidade de onda de pulso e a pressão arterial,variáveis antropométricas e metabólicas, incluindo as adipocitocinas, em indiví [...] duos adultos jovens. MÉTODOS: Foram avaliados 96 indivíduos (51 homens) do estudo do Rio de Janeiro, de 26 a 35 anos (média 30,09 ± 1,92). Foram obtidos a velocidade de onda de pulso (método Complior), pressão arterial, índice de massa corporal, glicose, perfil lipídico, leptina, insulina, adiponectina e o índice de resistência à insulina HOMA-IR. Os indivíduos foram estratificados em três grupos segundo o tercil da VOP para cada sexo. RESULTADOS: O grupo com maior tercil de VOP mostrou maiores médias de pressão arterial sistólica, pressão arterial diastólica, pressão arterial média, índice de massa corporal, insulina, HOMA-IR e menores médias de adiponectina, além de maiores prevalências de diabetes mellitus/intolerância à glicose e hiperinsulinemia. Houve correlação significativa e positiva da velocidade da onda de pulso com pressão arterial sistólica, pressão arterial diastólica, pressão de pulso e pressão arterial média, índice de massa corporal, e LDL-colesterol e negativa com HDL-colesterol e adiponectina. Em modelo de regressão múltipla, após ajuste do HDL-colesterol, LDL-colesterol e adiponectina para sexo, idade, índice de massa corporal e pressão arterial média, apenas o sexo masculino e a pressão arterial média mantiveram correlação significativa com a velocidade de onda de pulso. CONCLUSÃO: A velocidade de onda de pulso em adultos jovens mostrou relação significativa com variáveis de risco cardiovascular, destacando-se o sexo masculino e a pressão arterial média como importantes variáveis no seu determinismo. Os achados sugerem que a medida da VOP pode ser útil para a identificação do acometimento vascular nessa faixa etária. Abstract in english BACKGROUND: Data on noninvasive vascular assessment and their association with cardiovascular risk variables are scarce in young individuals. OBJECTIVE: To evaluate the association between pulse wave velocity and blood pressure, anthropometric and metabolic variables, including adipocytokines, in yo [...] ung adults. METHODS: A total of 96 individuals aged 26 to 35 years (mean 30.09 ± 1.92; 51 males) were assessed in the Rio de Janeiro study. Pulse wave velocity (Complior method), blood pressure, body mass index, glucose, lipid profile, leptin, insulin, adiponectin and insulin resistance index (HOMA-IR) were analyzed. Subjects were stratified into three groups according to the PWV tertile for each gender. RESULTS: The group with the highest pulse wave velocity (PWV) tertile showed higher mean systolic and diastolic blood pressure, mean blood pressure, body mass index, insulin, and HOMA-IR, as well as lower mean adiponectin; higher prevalence of diabetes mellitus/glucose intolerance and hyperinsulinemia. There was a significant positive correlation of PWV with systolic blood pressure, diastolic blood pressure, pulse pressure and mean blood pressure, body mass index, and LDL-cholesterol, and a negative correlation with HDL-cholesterol and adiponectin. In the multiple regression model, after adjustment of HDL-cholesterol, LDL-cholesterol and adiponectin for gender, age, body mass index and mean blood pressure, only the male gender and mean blood pressure remained significantly correlated with PWV. CONCLUSION: PWV in young adults showed a significant association with cardiovascular risk variables, especially in the male gender, and mean blood pressure as important determinant variables. The findings suggest that PWV measurement can be useful for the identification of vascular impairment in this age group.

Oswaldo Luiz, Pizzi; Andréa Araujo, Brandão; Roberto, Pozzan; Maria Eliane Campos, Magalhães; Erika Maria Gonçalves, Campana; Flavia Lopes, Fonseca; Elizabete Viana de, Freitas; Ayrton Pires, Brandão.

2013-01-01

211

Left ventricular function during lower body negative pressure  

Science.gov (United States)

The response of the human left ventricle to lower body negative pressure (LBNP) and the relation between left ventricular function and hemodynamic response were investigated. Ventricular function curves relating stroke volume to end-diastolic volume were obtained in 12 normal men. Volume data were derived from echocardiographic measurements of left ventricular end-systolic and end-diastolic diameters at rest and during lower body negative pressure (LBNP) at minus 40 mm Hg. End-diastolic volume decreased by 19% and stroke volume by 22%. There were no significant changes in heart rate, arterial blood pressure, or end-systolic volume. Thus, moderate levels of LBNP significantly reduce preload and stroke volume without affecting contractile state. The absence of significant changes in heart rate and arterial blood pressure in the presence of a significant reduction in stroke volume is consistent with an increase in systemic peripheral resistance mediated by low-pressure baroreceptors.

Ahmad, M.; Blomqvist, C. G.; Mullins, C. B.; Willerson, J. T.

1977-01-01

212

The interaction between pindolol and epinephrine contained in local anesthetic solution to the left ventricular diastolic filling velocity in normal subjects.  

Digital Repository Infrastructure Vision for European Research (DRIVER)

To evaluate the interaction between the nonselective beta-blocker, pindolol, and epinephrine contained in a local anesthetic solution, the left ventricular diastolic filling velocity was examined with pulsed Doppler echocardiography. Arterial blood pressure (BP), the R-R interval on the electrocardiogram (RR), and Doppler echo-cardiographic measurements were recorded in seven healthy volunteers after 45 micrograms of epinephrine contained in lidocaine (L-E) was injected in the maxilla after p...

Niwa, H.; Shibutani, T.; Hori, T.; Kim, Y.; Akita, M.; Matsuura, H.

1996-01-01

213

Comment on: Serum cholesterol and LDL-C in association with level of diastolic blood pressure in type 2 diabetic patients  

Directory of Open Access Journals (Sweden)

Full Text Available Implication for health policy/practice/research/medical education:Monitoring of blood pressure and serum lipids would be beneficial for diabetic patients in preventing the disease progression especially diabetic nephropathy in this population.

Nasri Hamid

2012-12-01

214

Hospitalizations Due to Unstable Angina Pectoris in Diastolic and Systolic Heart Failure  

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Patients with diastolic heart failure (HF) i.e. clinical HF with normal or near normal left ventricular ejection fraction (LVEF) may experience unstable angina pectoris (UAP) due to epicardial atherosclerotic coronary artery disease (CAD) and/or to subendocardial ischemia, even in the absence of CAD. However, the risk of UAP among ambulatory diastolic HF patients has not been well studied. We examined incident hospitalizations due to UAP among 916 diastolic HF (LVEF >45%) patients without sig...

Ahmed, Ali; Zile, Michael R.; Rich, Michael W.; Fleg, Jerome L.; Adams, Kirkwood F.; Love, Thomas E.; Young, James B.; Aronow, Wilbert S.; Kitzman, Dalane W.; Gheorghiade, Mihai; Dell’italia, Louis J.

2007-01-01

215

Variação da Pressão Arterial em Usuárias de Terapia de Reposição Hormonal / Variation of Blood Pressure in Users of Hormone Replacement Therapy  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese Objetivo: avaliar os efeitos da terapia de reposição hormonal sobre a pressão arterial sistólica e diastólica de mulheres na pós-menopausa. Casuística e Métodos: foram avaliadas retrospectivamente 166 usuárias e 136 não-usuárias de reposição hormonal, acompanhadas no Ambulatório de Menopausa do Cent [...] ro de Atenção Integral à Saúde da Mulher da Universidade Estadual de Campinas por um período de três anos. Avaliamos a variação desses parâmetros em relação aos valores iniciais. A análise dos dados foi realizada usando-se o teste t de Student, o Teste de Mann-Whitney e o teste não-paramétrico de Wilcoxon. Resultados: observou-se que a pressão arterial sistólica das usuárias de terapia de reposição hormonal foi menor ao final do terceiro ano de uso quando comparada com os valores iniciais (p = 0,01). Não houve diferença significativa na pressão arterial diastólica entre as usuárias e as não-usuárias. Conclusão: a terapia de reposição hormonal não produziu alterações nos parâmetros estudados em mulheres adequadamente acompanhadas durante o seu uso. Abstract in english Purpose: to evaluate the effects of hormone replacement therapy (HRT) on the systolic and diastolic blood pressure of postmenopausal women. Methods: a total of 166 users and 136 non-users of hormone replacement were evaluated retrospectively during a period of three years. All women were assisted at [...] the Menopause Outpatient Clinic of CAISM -- Unicamp, where the variations of these parameters were evaluated at the end of each year in relation to the initial parameters. The data analysis was performed through Student's t test, Mann-Whitney test, and the Wilcoxon nonparametric test. Results: we observed that the systolic blood pressure of HRT users was statistically lower at the end of the third year of use, compared to the initial values (p = 0.01). There was no significant difference in the diastolic blood pressure between users and non-users. Conclusion: hormone replacement therapy did not produce changes in the parameters studied in women properly assisted during the use of HRT.

José Alaércio de Toledo, Lima-Junior; Aarão Mendes, Pinto-Neto; Lúcia Helena Simões, Costa-Paiva; Adriana Orcesi, Pedro.

2000-06-01

216

Numerical simulation of blood flow and pressure drop in the pulmonary arterial and venous circulation.  

Science.gov (United States)

A novel multiscale mathematical and computational model of the pulmonary circulation is presented and used to analyse both arterial and venous pressure and flow. This work is a major advance over previous studies by Olufsen et al. (Ann Biomed Eng 28:1281-1299, 2012) which only considered the arterial circulation. For the first three generations of vessels within the pulmonary circulation, geometry is specified from patient-specific measurements obtained using magnetic resonance imaging (MRI). Blood flow and pressure in the larger arteries and veins are predicted using a nonlinear, cross-sectional-area-averaged system of equations for a Newtonian fluid in an elastic tube. Inflow into the main pulmonary artery is obtained from MRI measurements, while pressure entering the left atrium from the main pulmonary vein is kept constant at the normal mean value of 2 mmHg. Each terminal vessel in the network of 'large' arteries is connected to its corresponding terminal vein via a network of vessels representing the vascular bed of smaller arteries and veins. We develop and implement an algorithm to calculate the admittance of each vascular bed, using bifurcating structured trees and recursion. The structured-tree models take into account the geometry and material properties of the 'smaller' arteries and veins of radii ? 50 ?m. We study the effects on flow and pressure associated with three classes of pulmonary hypertension expressed via stiffening of larger and smaller vessels, and vascular rarefaction. The results of simulating these pathological conditions are in agreement with clinical observations, showing that the model has potential for assisting with diagnosis and treatment for circulatory diseases within the lung. PMID:24610385

Qureshi, M Umar; Vaughan, Gareth D A; Sainsbury, Christopher; Johnson, Martin; Peskin, Charles S; Olufsen, Mette S; Hill, N A

2014-10-01

217

[Effect of intraventricular injection of substance P on pulmonary and carotid arterial pressure in rabbits].  

Science.gov (United States)

In the present investigation changes of pulmonary and carotid arterial pressure in response to injection of substance P(SP) into the 4th ventricle of rabbits were studied. The results were as follows: (1) Intraventricular (ivt.) injection of SP could induce either an increase or a decrease in pulmonary arterial pressure as well as carotid arterial pressor response and bradycardia. (2) Bilateral cervical vagotomy could initiate a definite pulmonary pressor response and a marked decrease in the bradycardiac response to injection of SP in those rabbits originally showing a depressor response of pulmonary artery to SP. (3) Pretreatment by i.c.v. and i.v. phentolamine or alpha 1 blocker, prazosin, could block both the SP-induced pulmonary and carotid pressor responses. (4) alpha 2 blocker, yohimbine, or naloxone could enhance the pressor responses in the both arteries. (5) Propranolol had no effect on the pressor responses in both arteries. (6) The cardiovascular responses to SP could be blocked by the SP blocker (D-Pro2.D-Trp7.9)-SP. It is assumed that increase of SP in the brain may induce an increase in both the pulmonary and carotid arterial pressures and bradycardia by activating the SP receptors. The central mechanism responsible for the SP- induced pressor response involves the participation of adrenergic alpha 1 receptor activities, while the central adrenergic alpha 2 receptor system as well as the endorphin system exerts an inhibitory modulation on the central SP-induced pressor pathway. It appears that SP, catecholamine and opiate substance are all involved in the regulation of blood pressure by brain stem. PMID:7689252

Ni, H; Zhang, X H

1993-04-01

218

Arterial blood pressure of term newborns during the first week of life  

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Full Text Available The progressive behavior of the blood pressure of term newborns during the first week of life was assessed by the simultaneous use of oscillometric and Doppler methods. A total of 174 term neonates born at the Municipal Hospital Odilon Behrens in Belo Horizonte, from March 1996 to February 1997, were prospectively assessed. The oscillometric and Doppler ultrasonic methods were simultaneously used for four consecutive recordings obtained at 12 ± 6, 24 ± 6 and 72 ± 24 h and on the 7th ± 1 day of life. The combined use of the two methods simplified the procedure, with automatic cuff inflation and deflation, and speed was properly controlled with an automatic pressure monitor. The procedure was performed using a Y-connection to the mercury sphygmomanometer, with blood pressure being recorded with an automatic device and systolic blood pressure being measured simultaneously by Doppler ultrasound. The newborns were awake, not crying and in the supine position. A statistically significant increase in systolic and diastolic blood pressure was observed between the first and second, and the third and fourth measurements by Doppler and oscillometric methods. No significant correlation between birth weight, length, ponderal index and blood pressure was observed. The technique used represents a simpler and more accurate procedure for blood pressure measurement.

M.C.V.A. Nascimento

2002-08-01

219

Arterial blood pressure of term newborns during the first week of life  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in english The progressive behavior of the blood pressure of term newborns during the first week of life was assessed by the simultaneous use of oscillometric and Doppler methods. A total of 174 term neonates born at the Municipal Hospital Odilon Behrens in Belo Horizonte, from March 1996 to February 1997, wer [...] e prospectively assessed. The oscillometric and Doppler ultrasonic methods were simultaneously used for four consecutive recordings obtained at 12 ± 6, 24 ± 6 and 72 ± 24 h and on the 7th ± 1 day of life. The combined use of the two methods simplified the procedure, with automatic cuff inflation and deflation, and speed was properly controlled with an automatic pressure monitor. The procedure was performed using a Y-connection to the mercury sphygmomanometer, with blood pressure being recorded with an automatic device and systolic blood pressure being measured simultaneously by Doppler ultrasound. The newborns were awake, not crying and in the supine position. A statistically significant increase in systolic and diastolic blood pressure was observed between the first and second, and the third and fourth measurements by Doppler and oscillometric methods. No significant correlation between birth weight, length, ponderal index and blood pressure was observed. The technique used represents a simpler and more accurate procedure for blood pressure measurement.

M.C.V.A., Nascimento; C.C., Xavier; E.M.A., Goulart.

2002-08-01

220

Strophanthus hispidus attenuates the Ischemia-Reperfusion induced myocardial Infarction and reduces mean arterial pressure in renal artery occlusion  

Science.gov (United States)

Background: The myocardium is generally injured in the case of reperfusion injury and arterial damage is caused by hypertension. In reference to these statements, the present study was focused. Cardiac glycosides were said to have protective effects against myocardial infarction and hypertension. Strophanthus hispidus was thus incorporated in the study. Objective: The prime objective of the study was to investigate the protective effects of Strophanthus hispidus against ischemia-reperfusion myocardial Infarction and renal artery occluded hypertension in rats. Materials and Methods: The animal model adopted was surgically-induced myocardial ischemia, performed by means of left anterior descending coronary artery occlusion (LAD) for 30 min followed by reperfusion for another 4 h. Infarct size was assessed by using the staining agent TTC (2,3,5-triphenyl tetrazolium chloride). Hypertension was induced by clamping the renal artery with renal bulldog clamp for 4 h. Results: The study was fruitful by the effect of Strophanthus hispidus on infarction size, which got reduced to 27.2 ± 0.5and 20.0 ± 0.2 by 500 mg/Kg and 1000 mg/Kg ethanolic extracts which was remarkably significant when compared with that of the control group 52.8 ± 4.6. The plant extract did reduce heart rate at various time intervals. There was also a protective effect in the case of mean arterial blood pressure were the 500 mg/Kg and 1000 mg/Kg of the plant extract did reduce the hypertension after 60 minutes was 60.0 ± 4.80 and 50.50 ± 6.80. Conclusion: The results suggest that 500 mg/Kg and 100 mg/Kg ethanolic extract of Strophanthus hispidus was found to possess significant cardiac protective and anti-hypertensive activity. PMID:25298674

Gundamaraju, Rohit; Vemuri, Ravi Chandra; Singla, Rajeev K; Manikam, Rishya; Rao, A Ranga; Sekaran, Shamala Devi

2014-01-01

 
 
 
 
221

Study the effect of exercise on systolic pulmonary artery pressure in healthy subjects  

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Full Text Available Introduction: As no data is available concerning the cut-off value defining abnormal pulmonary artery systolic pressure (PASP response in subjects of various ages, the aim of this study is to assess physiological PASP response to exercise in healthy individuals of various ages. Material and methods: One hundred and twenty three healthy volunteers, aged 30 to 70 years, underwent Doppler echocardiographic measurements at rest and after treadmill exercise test. Pulmonary artery systolic pressure was estimated at rest, and immediately after peak exercise using Bernoulli formula (four times tricuspid valve regurgitation velocity squared adding an estimated right atrial pressure. Results: Lower and upper limits of PASP during rest was 7 and 28 mmHg and after peak exercise was 14 and 48 mmHg respectively. After exercise, PASP increased from rest (14 ± 4 mmHg to peak (25 ± 7 mmHg. Pulmonary artery systolic pressure during rest and peak exercise, increased with age, but has no correlation with body mass index or gender. Conclusion: Pulmonary artery systolic pressure at peak exercise can frequently reach values ? 30 mmHg in healthy individuals with good exercise capacity, especially in elderly individuals, which goes beyond pathologic definitions of pulmonary hypertension.

Mohammad Nourizadeh

2012-04-01

222

Aptidão cardiorrespiratória, excesso de peso e pressão arterial elevada em adolescentes Cardiorespiratory fitness, surplus weight and high blood pressure in adolescents  

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Full Text Available OBJETIVO: Analisar a associação entre aptidão cardiorrespiratória, excesso de peso e pressão arterial elevada em repouso entre alunos da rede privada de ensino. MÉTODOS: Participaram do estudo 205 jovens de ambos os sexos com idades entre 11 e 14 anos. Foram aferidos valores de massa corporal, estatura, pressão arterial sistólica, diastólica e teste de corrida. A análise estatística foi composta de valores de média,desvio-padrão, teste do Qui-quadrado e regressão de Poisson. RESULTADOS: A prevalência de excesso de peso foi de 40,6% para o sexo masculino e 28,4% para o feminino (p = 0,091, e a pressão arterial elevada em repouso foi de 20,8% para o sexo masculino e 13,8% para o feminino (p = 0,247. O excesso de peso apresentou associação significante com a pressão arterial elevada (RP = 3,92 [1,54-9,98]; entretanto, o resultado no teste de corrida, não (RP = 0,60 [0,23-1,56]. CONCLUSÃO: Conclui-se que a associação entre aptidão cardiorrespiratória e pressão arterial elevada parece ser mediada pelo estado nutricional.OBJECTIVE: To analyze the association among cardiorespiratory fitness, surplus weight and high blood pressure in school children from the private sector. METHODS: 205 young students with age ranging from 11 to 14 years old It were recruited to participate in the study. Body mass, stature, systolic and diastolic blood pressure were measured and a running test was applied. The statistic procedures were composed of medians, interquartile interval, chi-square test and Poisson regression. RESULTS: The prevalence of surplus weight was of 40.6% for the male sex and 28.4% for the female sex (p= 0.091, and the occurrence of high blood pressure was of 20.8% for the male sex and 13.8% for the female sex (p = 0.247. There was association between surplus weight and high blood pressure (PR= 3.92 [1.54-9.98]; however, no association was found for surplus weight and the running test (PR= 0.60 [0.23-1.56]. CONCLUSION: It was concluded that the association between cardiorespiratory fitness is mediated by the nutritional status.

Rômulo Araújo Fernandes

2010-12-01

223

Arterial stiffness is associated with increase in blood pressure over time in treated hypertensives.  

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Arterial stiffness is associated with incident hypertension. We hypothesized that measures of arterial stiffness would predict increases in systolic (SBP), mean (MAP), and pulse pressure (PP) over time in treated hypertensives. Blood pressure (BP) was measured a mean of 8.5 ± 0.9 years apart in 414 non-Hispanic white hypertensives (mean age, 60 ± 8 years; 55% women). The average of three supine right brachial BPs was recorded. Measures of arterial stiffness, including carotid-femoral pulse wave velocity (cfPWV), aortic augmentation index (AIx), and central pulse pressure (CPP), were obtained at baseline by applanation tonometry. We performed stepwise multivariable linear regression analyses adjusting for potential confounders to assess the associations of arterial stiffness parameters with BP changes over time. SBP, MAP, and PP increased in 80% of participants. After adjustment for covariates listed, cfPWV (m/s) was associated with increases in SBP (? ± standard error [SE], 0.71 ± 0.31) and PP (? ± SE, 1.09 ± 0.27); AIx (%) was associated with increases in SBP (? ± SE, 0.23 ± 0.10) and MAP (? ± SE, 0.27 ± 0.07); and CPP (mmHg) was associated with increases in SBP (? ± SE, 0.44 ± 0.07), MAP (? ± SE, 0.24 ± 0.05), and PP (? ± SE, 0.42 ± 0.06) over time (P ? .02 for each). In conclusion, arterial stiffness measures were associated with longitudinal increases in SBP, MAP, and PP in treated hypertensives. PMID:24952654

Coutinho, Thais; Bailey, Kent R; Turner, Stephen T; Kullo, Iftikhar J

2014-06-01

224

Cardiac systolic and diastolic function during whole body heat stress  

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During a whole body heat stress, stroke volume is either maintained or slightly elevated despite reduced ventricular filling pressures and central blood volume, suggestive of improved cardiac diastolic and/or systolic function. Heat stress improves cardiac systolic and diastolic function in patients with congestive heart failure, although it remains unknown whether similar responses occur in healthy individuals, which is the hypothesis to be tested. Nine male volunteers underwent a whole body...

Brothers, R. Matthew; Bhella, Paul S.; Shibata, Shigeki; Wingo, Jonathan E.; Levine, Benjamin D.; Crandall, Craig G.

2009-01-01

225

Relationship between pulmonary artery volumes at computed tomography and pulmonary artery pressures in patients with- and without pulmonary hypertension  

Energy Technology Data Exchange (ETDEWEB)

Objectives: This study was designed to determine the relationship between pulmonary artery (PA) volumes at computed tomography (CT) and PA pressures at right-sided heart catheterization in patients with and without pulmonary hypertension (PAH) to develop a noninvasive CT method of PA pressure quantification. Materials and methods: Sixteen patients with chronic sleep apnea syndrome underwent contrast enhanced helical CT (slice thickness 3 mm; pitch 2; increment 2 mm) at inspiration. Eight patients had PAH while cardiopulmonary disease has been excluded in eight other patients. Vascular volumes were determined using a 3D technique (threshold seeded vascular tracing algorithm; thresholds -600 H [lower] and 3000 H [upper]). Right-sided heart catheterization measurements were available for linear regression analysis of PA volumes and pressures. Results: Correlation between PA pressures and volumes (normalized for BMI), was high in both groups (without PAH: r = .85; with PAH .90, Pearson). Compared to elevated PA pressures in patients with pulmonary hypertension (p < .005), PA volumes also were significantly increased (p < .05) among the groups. Conclusions: High correlation was found between PA volumes and mean PA pressures in patients with- and without PAH. Significant differences in PA volumes at CT-volumetry may admit non-invasive determination of pulmonary hypertension.

Froelich, Jens J. [Department of Radiology, Philipps-University Hospital, Baldingerstrasse, 35043 Marburg (Germany)], E-mail: jens.froelich@klinikum-hef.de; Koenig, Helmut [Department of Radiology, Philipps-University Hospital, Baldingerstrasse, 35043 Marburg (Germany)], E-mail: helmut.koenig@siemens.com; Knaak, Lennard [Department of Medicine, Philipps-University Hospital, Baldingerstrasse, 35043 Marburg (Germany)], E-mail: froehlic@staff.uni-marburg.de; Krass, Stefan [MeVis Research, Universitaetsallee 29, 28359 Bremen (Germany)], E-mail: krass@mevis.de; Klose, Klaus J. [Department of Radiology, Philipps-University Hospital, Baldingerstrasse, 35043 Marburg (Germany)], E-mail: klose@med.uni-marburg.de

2008-09-15

226

Relationship between pulmonary artery volumes at computed tomography and pulmonary artery pressures in patients with- and without pulmonary hypertension  

International Nuclear Information System (INIS)

Objectives: This study was designed to determine the relationship between pulmonary artery (PA) volumes at computed tomography (CT) and PA pressures at right-sided heart catheterization in patients with and without pulmonary hypertension (PAH) to develop a noninvasive CT method of PA pressure quantification. Materials and methods: Sixteen patients with chronic sleep apnea syndrome underwent contrast enhanced helical CT (slice thickness 3 mm; pitch 2; increment 2 mm) at inspiration. Eight patients had PAH while cardiopulmonary disease has been excluded in eight other patients. Vascular volumes were determined using a 3D technique (threshold seeded vascular tracing algorithm; thresholds -600 H [lower] and 3000 H [upper]). Right-sided heart catheterization measurements were available for linear regression analysis of PA volumes and pressures. Results: Correlation between PA pressures and volumes (normalized for BMI), was high in both groups (without PAH: r = .85; with PAH .90, Pearson). Compared to elevated PA pressures in patients with pulmonary hypertension (p < .005), PA volumes also were significantly increased (p < .05) among the groups. Conclusions: High correlation was found between PA volumes and mean PA pressures in patients with- and without PAH. Significant differences in PA volumes at CT-volumetry may admit non-invasive determination of pulmonary hypertension

227

Blood pressure and mesenteric resistance arterial function after spaceflight  

Science.gov (United States)

Ground studies indicate that spaceflight may diminish vascular contraction. To examine that possibility, vascular function was measured in spontaneously hypertensive rats immediately after an 18-day shuttle flight. Isolated mesenteric resistance arterial responses to cumulative additions of norepinephrine, acetylcholine, and sodium nitroprusside were measured using wire myography within 17 h of landing. After flight, maximal contraction to norepinephrine was attenuated (P < 0.001) as was relaxation to acetylcholine (P < 0.001) and sodium nitroprusside (P < 0.05). At high concentrations, acetylcholine caused vascular contraction in vessels from flight animals but not in vessels from vivarium control animals (P < 0.05). The results are consistent with data from ground studies and indicate that spaceflight causes both endothelial-dependent and endothelial-independent alterations in vascular function. The resulting decrement in vascular function may contribute to orthostatic intolerance after spaceflight.

Hatton, Daniel C.; Yue, Qi; Chapman, Justin; Xue, Hong; Dierickx, Jacqueline; Roullet, Chantal; Coste, Sarah; Roullet, Jean Baptiste; McCarron, David A.

2002-01-01

228

Determinação da pressão arterial em recém-nascidos =Determination of blood pressure in newborns  

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Full Text Available Objetivo: descrever as recomendações para a determinação da pressão arterial em recém-nascidos, os métodos e instrumentos utilizados. Fonte de dados: revisão de artigos médicos sobre pressão arterial em recém-nascidos publicados nos últimos vinte anos (base de dados: MEDLINE, PubMed e artigos originais sobre o método do “flush”. Síntese de dados: vários fatores dificultam as medidas e interpretação da pressão arterial em neonatos, como tamanho variável do braço, dificuldade de obtenção em recém-nascidos chorosos e variação na pressão arterial quanto à idade gestacional e peso. A medida da pressão arterial deve ser realizada preferencialmente no braço direito, com a largura do manguito correspondendo a 40% da circunferência do braço e que envolva 80% a 100% da respectiva extremidade. Atualmente, os métodos de monitorização não-invasiva da pressão arterial estão bem difundidos, especialmente o uso da oscilometria automática. Além disso, o antigo método do “flush” e a técnica da oximetria de pulso têm sido citados na literatura. Como limitação mais importante encontra-se a ausência de validação dos equipamentos em neonatologia, especialmente dos monitores oscilométricos. Conclusões: dois elementos importantes para obtenção de pressões arteriais exatas são um bebê calmo e um manguito de tamanho adequado. Todos os métodos descritos são adequados para a mensuração da pressão arterial em recém-nascidos. Objective: To describe the recommendations for the determination of the blood pressure in newborn, the methods and the devices. Sources of data: Review of medical articles about blood pressure in newborn published in the last twenty years (database: Medline, PubMed and original articles about the flush method. Summary of the findings: Several factors complicate the measures and interpretation of the blood pressure in newborns, like variable size of the upper arm, difficulty in tearful newborn and variation in the blood pressure regarding the weight and gestational age. The measure of the blood pressure should be performed preferentially in the right upper arm, with cuff size corresponding to 40% of the circumference of the upper arm and that involves 80% to 100% of the respective extremity. Nowadays, noninvasive measurements methods of the blood pressure feel well spread, especially the use of oscillometric automatic. Moreover, the antique flush method and pulse oximetry techniques have been being cited in the literature. Like more important limitation to meets itself the validation absence of the devices in neonatology, especially in the oscillometrics devices. Conclusions: Two important elements for obtainment of exact blood pressures are a calm baby and a adequate cuff size and all described methods are adequate for measurement of the blood pressure.

Fiori, Renato Machado

2007-01-01

229

Brachial artery vasomotion and transducer pressure effect on measurements by active contour segmentation on ultrasound  

Energy Technology Data Exchange (ETDEWEB)

Purpose: To use feed-forward active contours (snakes) to track and measure brachial artery vasomotion on ultrasound images recorded in both transverse and longitudinal views; and to compare the algorithm's performance in each view. Methods: Longitudinal and transverse view ultrasound image sequences of 45 brachial arteries were segmented by feed-forward active contour (FFAC). The segmented regions were used to measure vasomotion artery diameter, cross-sectional area, and distention both as peak-to-peak diameter and as area. ECG waveforms were also simultaneously extracted frame-by-frame by thresholding a running finite-difference image between consecutive images. The arterial and ECG waveforms were compared as they traced each phase of the cardiac cycle. Results: FFAC successfully segmented arteries in longitudinal and transverse views in all 45 cases. The automated analysis took significantly less time than manual tracing, but produced superior, well-behaved arterial waveforms. Automated arterial measurements also had lower interobserver variability as measured by correlation, difference in mean values, and coefficient of variation. Although FFAC successfully segmented both the longitudinal and transverse images, transverse measurements were less variable. The cross-sectional area computed from the longitudinal images was 27% lower than the area measured from transverse images, possibly due to the compression of the artery along the image depth by transducer pressure. Conclusions: FFAC is a robust and sensitive vasomotion segmentation algorithm in both transverse and longitudinal views. Transverse imaging may offer advantages over longitudinal imaging: transverse measurements are more consistent, possibly because the method is less sensitive to variations in transducer pressure during imaging.

Cary, Theodore W.; Sultan, Laith R.; Sehgal, Chandra M., E-mail: sehgalc@uphs.upenn.edu [Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 (United States); Reamer, Courtney B.; Mohler, Emile R. [Department of Medicine, Division of Cardiovascular Medicine, Section of Vascular Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 (United States)

2014-02-15

230

Muscle metaboreflex activation speeds the recovery of arterial blood pressure following acute hypotension in humans.  

Science.gov (United States)

It has been suggested that the arterial baroreflex and muscle metaboreflex are both activated during heavy exercise and that they interact to modulate primary cardiovascular reflex responses. This proposed interaction and its consequences are not fully understood, however. The purpose of present study was to test our hypothesis that dynamic arterial baroreflex-mediated cardiovascular responses to acute systemic hypotension in humans are augmented when the muscle metaboreflex is active and that this results in a faster recovery of arterial blood pressure. Acute hypotension was induced nonpharmacologically in 12 healthy subjects by releasing bilateral thigh cuffs after 9 min of suprasystolic resting ischemia, with and without muscle metaboreflex activation via postexercise muscle ischemia (PEMI) after 1 min of isometric handgrip exercise at 50% maximum voluntary contraction. The thigh-cuff release evoked rapid reductions in mean arterial pressure (MAP) and increases in heart rate, cardiac output (Doppler), and total vascular conductance (TVC) under control conditions and during PEMI. The reductions in MAP from baseline were greater and the increases in TVC were smaller during PEMI than control. In addition, arterial baroreflex-mediated peripheral vasoconstriction was augmented during PEMI, as evidenced by a near doubling of the rate of recovery of MAP and TVC. These results show that when the muscle metaboreflex is activated in humans, arterial baroreflex-mediated peripheral vasoconstriction elicited in response to acute hypotension is augmented, which halves the time needed for MAP recovery. Such modulation of baroreflex function would be advantageous for maintaining an elevated arterial blood pressure during activation of the muscle metaboreflex. PMID:23542922

Ichinose, Masashi; Watanabe, Kazuhito; Fujii, Naoto; Kondo, Narihiko; Nishiyasu, Takeshi

2013-06-01

231

Effects of an exercise program on blood pressure in patients with treated hypertension and chronic Chagas' heart disease / Efeitos de um programa de exercícios na pressão arterial de pacientes com hipertensão controlada e cardiopatia chagásica crônica  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in portuguese INTRODUÇÃO: Estudos prévios descrevem um desequilíbrio do sistema nervoso autônomo na doença de Chagas causando maior atividade simpática, o que poderia influenciar na gênese da hipertensão arterial. No entanto, pacientes submetidos a exercícios físicos regulares poderiam contrapor esta condição, vi [...] sto que o exercício provoca respostas fisiológicas através de adaptações autonômicas e hemodinâmicas que influenciam positivamente o sistema cardiovascular. O presente estudo se propõe a avaliar os efeitos da reabilitação cardíaca sobre a pressão arterial em pacientes hipertensos com cardiopatia chagásica crônica. MÉTODOS: Foram recrutados 17 pacientes submetidos a um programa regular de exercícios durante 24 semanas, sendo utilizado monitorização ambulatorial da pressão arterial (MAPA) antes e após o treinamento. Foi descrita a diferença da pressão arterial sistólica (PAS), pressão arterial diastólica (PAD) e pressão arterial média (PAM) do início ao fim estudo. RESULTADOS: As pressões foram avaliadas de forma geral e nos períodos de vigília e sono, respectivamente: PAS (p=0,34; 0,23; 0,85), PAD (p=0,46; 0,44; 0,94) e PAM (p=0,41; 0,30; 0,97). CONCLUSÕES: Não houve diferença estatisticamente significativa na variação da pressão arterial após o período de reabilitação cardíaca de 24 semanas, no entanto, evidenciamos que o treinamento físico é seguro em pacientes com cardiopatia chagásica crônica, não ocorrendo aumento da pressão arterial. Abstract in english INTRODUCTION: Previous studies describe an imbalance of the autonomic nervous system in Chagas' disease causing increased sympathetic activity, which could influence the genesis of hypertension. However, patients undergoing regular physical exercise could counteract this condition, considering that [...] exercise causes physiological responses through autonomic and hemodynamic changes that positively affect the cardiovascular system. This study aimed to evaluate the effects of an exercise program on blood pressure in hypertensive patients with chronic Chagas' heart disease. METHODS: We recruited 17 patients to a 24-week regular exercise program and used ambulatory blood pressure monitoring before and after training. We determined the differences in the systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean blood pressure (MBP) from the beginning to the end of the study. RESULTS: The blood pressures were evaluated in general and during periods of wakefulness and sleep, respectively: SBP (p = 0.34; 0.23; 0.85), DBP (p = 0.46; 0.44; 0.94) and MBP (p = 0.41; 0.30; 0.97). CONCLUSIONS: There was no statistically significant change in blood pressure after the 24-week exercise program; however, we concluded that physical training is safe for patients with chronic Chagas' disease, with no incidence of increase in blood pressure.

Claudia Rosa de, Oliveira; Andréa Silvestre de, Sousa; Bráulio, Santos; Paloma Hargreaves, Fialho; Carla Cristiane Soares dos, Santos; Juliana Rega de, Oliveira; Marcus Vinícius, Souza.

232

Effects of an exercise program on blood pressure in patients with treated hypertension and chronic Chagas' heart disease / Efeitos de um programa de exercícios na pressão arterial de pacientes com hipertensão controlada e cardiopatia chagásica crônica  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in portuguese INTRODUÇÃO: Estudos prévios descrevem um desequilíbrio do sistema nervoso autônomo na doença de Chagas causando maior atividade simpática, o que poderia influenciar na gênese da hipertensão arterial. No entanto, pacientes submetidos a exercícios físicos regulares poderiam contrapor esta condição, vi [...] sto que o exercício provoca respostas fisiológicas através de adaptações autonômicas e hemodinâmicas que influenciam positivamente o sistema cardiovascular. O presente estudo se propõe a avaliar os efeitos da reabilitação cardíaca sobre a pressão arterial em pacientes hipertensos com cardiopatia chagásica crônica. MÉTODOS: Foram recrutados 17 pacientes submetidos a um programa regular de exercícios durante 24 semanas, sendo utilizado monitorização ambulatorial da pressão arterial (MAPA) antes e após o treinamento. Foi descrita a diferença da pressão arterial sistólica (PAS), pressão arterial diastólica (PAD) e pressão arterial média (PAM) do início ao fim estudo. RESULTADOS: As pressões foram avaliadas de forma geral e nos períodos de vigília e sono, respectivamente: PAS (p=0,34; 0,23; 0,85), PAD (p=0,46; 0,44; 0,94) e PAM (p=0,41; 0,30; 0,97). CONCLUSÕES: Não houve diferença estatisticamente significativa na variação da pressão arterial após o período de reabilitação cardíaca de 24 semanas, no entanto, evidenciamos que o treinamento físico é seguro em pacientes com cardiopatia chagásica crônica, não ocorrendo aumento da pressão arterial. Abstract in english INTRODUCTION: Previous studies describe an imbalance of the autonomic nervous system in Chagas' disease causing increased sympathetic activity, which could influence the genesis of hypertension. However, patients undergoing regular physical exercise could counteract this condition, considering that [...] exercise causes physiological responses through autonomic and hemodynamic changes that positively affect the cardiovascular system. This study aimed to evaluate the effects of an exercise program on blood pressure in hypertensive patients with chronic Chagas' heart disease. METHODS: We recruited 17 patients to a 24-week regular exercise program and used ambulatory blood pressure monitoring before and after training. We determined the differences in the systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean blood pressure (MBP) from the beginning to the end of the study. RESULTS: The blood pressures were evaluated in general and during periods of wakefulness and sleep, respectively: SBP (p = 0.34; 0.23; 0.85), DBP (p = 0.46; 0.44; 0.94) and MBP (p = 0.41; 0.30; 0.97). CONCLUSIONS: There was no statistically significant change in blood pressure after the 24-week exercise program; however, we concluded that physical training is safe for patients with chronic Chagas' disease, with no incidence of increase in blood pressure.

Claudia Rosa de, Oliveira; Andréa Silvestre de, Sousa; Bráulio, Santos; Paloma Hargreaves, Fialho; Carla Cristiane Soares dos, Santos; Juliana Rega de, Oliveira; Marcus Vinícius, Souza.

2012-12-01

233

Effects of an exercise program on blood pressure in patients with treated hypertension and chronic Chagas' heart disease Efeitos de um programa de exercícios na pressão arterial de pacientes com hipertensão controlada e cardiopatia chagásica crônica  

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Full Text Available INTRODUCTION: Previous studies describe an imbalance of the autonomic nervous system in Chagas' disease causing increased sympathetic activity, which could influence the genesis of hypertension. However, patients undergoing regular physical exercise could counteract this condition, considering that exercise causes physiological responses through autonomic and hemodynamic changes that positively affect the cardiovascular system. This study aimed to evaluate the effects of an exercise program on blood pressure in hypertensive patients with chronic Chagas' heart disease. METHODS: We recruited 17 patients to a 24-week regular exercise program and used ambulatory blood pressure monitoring before and after training. We determined the differences in the systolic blood pressure (SBP, diastolic blood pressure (DBP, and mean blood pressure (MBP from the beginning to the end of the study. RESULTS: The blood pressures were evaluated in general and during periods of wakefulness and sleep, respectively: SBP (p = 0.34; 0.23; 0.85, DBP (p = 0.46; 0.44; 0.94 and MBP (p = 0.41; 0.30; 0.97. CONCLUSIONS: There was no statistically significant change in blood pressure after the 24-week exercise program; however, we concluded that physical training is safe for patients with chronic Chagas' disease, with no incidence of increase in blood pressure.INTRODUÇÃO: Estudos prévios descrevem um desequilíbrio do sistema nervoso autônomo na doença de Chagas causando maior atividade simpática, o que poderia influenciar na gênese da hipertensão arterial. No entanto, pacientes submetidos a exercícios físicos regulares poderiam contrapor esta condição, visto que o exercício provoca respostas fisiológicas através de adaptações autonômicas e hemodinâmicas que influenciam positivamente o sistema cardiovascular. O presente estudo se propõe a avaliar os efeitos da reabilitação cardíaca sobre a pressão arterial em pacientes hipertensos com cardiopatia chagásica crônica. MÉTODOS: Foram recrutados 17 pacientes submetidos a um programa regular de exercícios durante 24 semanas, sendo utilizado monitorização ambulatorial da pressão arterial (MAPA antes e após o treinamento. Foi descrita a diferença da pressão arterial sistólica (PAS, pressão arterial diastólica (PAD e pressão arterial média (PAM do início ao fim estudo. RESULTADOS: As pressões foram avaliadas de forma geral e nos períodos de vigília e sono, respectivamente: PAS (p=0,34; 0,23; 0,85, PAD (p=0,46; 0,44; 0,94 e PAM (p=0,41; 0,30; 0,97. CONCLUSÕES: Não houve diferença estatisticamente significativa na variação da pressão arterial após o período de reabilitação cardíaca de 24 semanas, no entanto, evidenciamos que o treinamento físico é seguro em pacientes com cardiopatia chagásica crônica, não ocorrendo aumento da pressão arterial.

Claudia Rosa de Oliveira

2012-12-01

234

Frequency dependent effect of selective biphasic left vagus nerve stimulation on heart rate and arterial pressure  

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Full Text Available Activation of the parasympathetic pathway leads to negative chronotropic, dromotropic, and inotropic changes of heart function. The ability to selectively stimulate certain superficial compartments of peripheral nerves has been demonstrated previously. The aim of the present study was to find a clinically acceptable selective biphasic vagus nerve stimulation technique, which could allow gradual regulation of heart rate and systemic arterial pressure. In two patients, the left vagus nerve was stimulated with a combination of quasi-trapezoidal cathodic and rectangular anodic current pulses with different stimulation frequencies (10Hz, 20Hz, 30Hz and increasing current. The heart rate and systemic arterial pressure decreased with increasing current at all different stimulation frequencies (p<0.05. The heart rate and arterial pressure response was more gradual with 10Hz compared to 20Hz/30Hz vagus nerve stimulation (p<0.05. In conclusion, selective vagus nerve stimulation, with a combination of quasi-trapezoidal cathodic and rectangular anodic current pulses at 10Hz, offers gradual heart rate and systolic arterial pressure control.

MATEJ PODBREGAR

2012-10-01

235

Time-frequency analysis of arterial pressure oscillations in anesthetized dogs: effects of standardized hemorrhages.  

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The purpose of this preliminary study was to investigate the advantages of the time-frequency analysis through the Continuous Wavelet Transform (CWT) compared to classical Fourier analysis using the Fast Fourier Transform (FFT) in arterial pressure signals from anesthetized mongrel dogs before and during standardized hemorrhages. Systemic arterial pressure pulsations were recorded using catheter-tip manometers. CWT and FFT were applied to arterial pressure pulsations to obtain module coefficients of this transformation and its associated contours during the evolution of progressive hemorrhages, in amounts of 15, 34, and 66% of the estimated total blood volume. This mathematical analysis enabled us to identify the evolution of the frequency components of aortic valve functions, heart dynamics, respiratory influences, and vasomotor activities. Furthermore, we isolated the modulating signal of amplitude modulation phenomenon present in the arterial pressure records, as described in previous papers, being the heart rate carrier frequency. The CWT is a very sensitive and reliable procedure to analyze (time-frequency) the oscillatory phenomena in two dimensions, and to provide more information than the FFT. This new analytical procedure may provide new insights in the study of shock pathophysiology. PMID:11220643

Jiménez, R F; Günther, B; Torres, P

2001-02-01

236

Is There an Optimal Arterial Pressure Level in Patients with End-Stage Chronic Renal Failure Before and After Kidney Transplantation?  

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Full Text Available Arterial hypertension occurs in 100% cases of end-stage chronic renal failure (ESCRF. It significantly worsens ESCRF and provokes cardiovascular complications. The presence of uncontrolled arterial hypertension after kidney transplantation becomes a determining factor deteriorating the prognosis of patients. The aim of the investigation was to define the changes of arterial pressure (AP in patients with end-stage chronic renal failure before and after kidney transplantation, along with antihypertensive therapy, and determine the most safe arterial pressure levels, with the kidney continuing its optimal functioning. Materials and Methods. The study involved 31 patients (16 male, 15 female patients, who underwent kidney transplantation for ESCRF. The study included the kidney functioning monitoring for a month after the transplantation (5 examinations, and the analysis of hemodynamic, biochemical indices, with transplant function definition. With the aim of achieving optimal AP before and after kidney transplantation, we actively titrated antihypertensive medicinal preparations and studied the functional state of a transplant. Results. Arterial hypertension was diagnosed in 100% of patients before transplantation; its level decreasing, on average, to the next lower order. In early postoperative period on day 7±1 the patients’ systolic AP decreased from 159.4±13.2/98.7±5.6 to 137.1±9.4/84.8±8.1 mm Hg (p < 0.001, and by the time of discharge its level averaged 127.9±9.2/81.1±6.9 mm Hg. Before hospitalization the patients took on average 1.9±0.2 basic medications, on discharge — 2.9±0.1. The indices of creatinine and urea levels, glomerular filtration rate (GFR and proteinuria consistently normalized. Postoperative intensity of systemic AP decrease had no effect on GFR levels in patients with ESCRF: GFR insignificantly increased in higher systolic AP: R2=0.082; p=0.09; R^2=0.083; p=0.23. A month after kidney transplantation AP level appeared to be optimal in the range of 115–130 mm Hg, and with such AP values GFR indices significantly grew (R2=0.25; p=0.035; R^2=0.3; p=0.027. Diastolic AP level had no significant effect on transplant function. Conclusion. In 100% cases, ESCRF patients have a syndrome of II or III degree arterial hypertension. After kidney transplantation there is an independent AP increase by one-two AP increase degrees. Intensive AP decrease in ESCRF patients before transplantation results in GFR decline. After transplantation there is GFR increase with an active decrease of systolic AP in the range of 115–130 mm Hg.

I.V. Fomin

2014-06-01

237

Avaliação do monitor de medida de pressão arterial 0mron 705-CP para uso em adolescentes e adultos jovens Evaluation of the Omron 705-CP blood pressure measuring device for use in adolescents and young adults  

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Full Text Available OBJETIVO: Avaliar o monitor OMRON 705-CP de medida de pressão arterial em adolescentes e adultos jovens. MÉTODOS: De acordo com o protocolo da British Hypertension Society e da Association for the Advancement of Medical Instrumentation, realizamos a validação do aparelho em 60 adolescentes. O monitor foi conectado em Y com a coluna de mercúrio e foram realizadas 4 medidas consecutivas e simultâneas, analisadas as independentes e calculadas as diferenças médias entre as pressões e o desvio padrão dessas diferenças. Os resultados foram analisados de acordo com o sistema de grau do protocolo utilizado. RESULTADOS: Foram avaliadas 240 medidas. A idade média dos pacientes foi 16,3 anos. Quando comparada a medida realizada pela coluna de mercúrio com o aparelho houve uma diferença OBJECTIVE: To assess the Omron 705-CP monitor for measuring blood pressure in adolescents and young adults. METHODS: According to the protocols of the British Hypertension Society and the Association for the Advancement of Medical Instrumentation, we performed validation of the device in 60 adolescents. The Omron monitor was connected in Y to a mercury column. Four consecutive and simultaneous measurements were taken with the mercury column sphygmomanometer and the test device, were independently analyzed, and the mean differences between the blood pressure measurements and the standard deviations of those differences were calculated. The results were analyzed according to the grading system of the protocol used. RESULTS: Two hundred and forty measurements were evaluated. The mean age of the patients was 16.3 years. When the measurement performed with the mercury column sphygmomanometer was compared with that taken with the device, a difference < 15 mmHg was observed in 97.9% of the systolic and 98.8% of the diastolic blood pressure measurements; a difference < 10 mmHg was observed in 86.3% of the systolic and 90.4% of the diastolic blood pressure measurements, which was classified as grade A; a difference < 5 mmHg was observed in 59.1% of the systolic and 67% of the diastolic blood pressure measurements, and was classified as grade A/B. The mean difference and the standard deviation of that difference for the systolic blood pressure was 2.91±6.42 mmHg, and, for the diastolic blood pressure, it was 1.16±5.79 mmHg. CONCLUSION: The Omron 705-CP monitor proved to be useful for measuring blood pressure in adolescents according to the protocol used.

Erika Arai Furusawa

2005-05-01

238

Hemodynamic Effects of Fenofibrate and Coenzyme Q10 in Type 2 Diabetic Subjects With Left Ventricular Diastolic Dysfunction  

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OBJECTIVE—To investigate the effects of fenofibrate and coenzyme Q10 (CoQ) on diastolic function, ambulatory blood pressure (ABP), and heart rate (HR) in type 2 diabetic subjects with left ventricular diastolic dysfunction (LVDD).

Chew, Gerard T.; Watts, Gerald F.; Davis, Timothy M. E.; Stuckey, Bronwyn G. A.; Beilin, Lawrence J.; Thompson, Peter L.; Currie, Philip J.

2008-01-01

239

Fatores preditores para o óbito neonatal em gestações com diástole zero ou reversa na doplervelocimetria da artéria umbilical / Predictor parameters of neonatal death in gestations with absent or reverse end-diastolic flow in the umbilical artery doppler velocimetry  

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Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese OBJETIVO: avaliar os fatores de risco antenatais e pós-natais para o óbito neonatal em gestações com diástole zero (DZ) ou reversa (DR) na doplervelocimetria da artéria umbilical. MÉTODOS: estudo transversal, retrospectivo, inferencial, a partir de 48 prontuários de gestações únicas com DZ ou DR, id [...] ade gestacional entre 24 e 34 semanas, em uma maternidade no Nordeste do Brasil. A média de idade foi de 27,3 anos (DP: 7,9). Vinte (41,7%) eram primigestas. Síndromes hipertensivas foram observadas em 44 (91,7%) casos. Trinta e cinco (72,9%) apresentavam DZ e 13 (27,1%) DR. Procedeu-se inicialmente à análise univariada (teste t de Student e teste Exato de Fisher), relacionando os parâmetros com o desfecho avaliado (óbito neonatal). As variáveis que apresentaram associação significativa foram incluídas no modelo de regressão logística (Estatística de Wald). O nível de significância utilizado foi de 5%. RESULTADOS: a mortalidade perinatal foi de 64,6% (31/48). Ocorreram cinco óbitos fetais e 26 neonatais. A média de idade gestacional no momento do diagnóstico foi de 27,9 (DP: 2,8) semanas. A resolução da gestação antes de 24 horas após o diagnóstico ocorreu em 52,1% dos casos. Parto abdominal foi realizado em 85,4% dos casos. Os recém-nascidos pesaram em média 975,9 g (DP: 457,5). Vinte e quatro (57,1%) apresentaram Apgar menor que 7 no primeiro minuto e 21,4%, no quinto. A idade gestacional no momento do diagnóstico, o peso ao nascer e o Apgar de primeiro minuto revelaram-se variáveis significativamente relacionadas com o óbito neonatal (valores de p foram, respectivamente, 0,008; 0,004 e 0,020). As razões de chance foi de 6,6; 25,3 e 13,8 para o óbito neonatal, quando o diagnóstico foi estabelecido até a 28ª semana, peso Abstract in english PURPOSE: to evaluate the antenatal and postnatal risk factors of neonatal death in pregnancies with absent (DZ) or reverse (DR) end-diastolic flow in the umbilical artery. METHODS: a cross-sectional retrospective study based on data from 48 medical records of singleton pregnancies with DZ or DR, and [...] gestational age of 24 to 34 weeks, at a maternity in the Brazilian Northeast. Mean age was 27.3 (SD: 7.9) years. Twenty (41.7%) patients were primiparas. Hypertensive disorders were found in 44 (91.7%) cases. Thirty-five women (72.9%) had DZ and 13 (27.1%) had DR. Univariate analysis was firstly done (Student's t-test and Fisher's exact test) correlating the parameters with the assessed outcome (neonatal death). Variables that showed significant association were included in the logistic regression model (Wald statistics). The level of significance was set at 5%. RESULTS: The perinatal mortality rate was 64.6% (31/48). There were five stillbirths and 26 neonatal deaths. The mean gestational age at diagnosis was 27.9 (SD: 2.8) weeks. Deliveries before 24 hours after diagnosis occurred in 52.1% of the cases. Cesarean section was performed in 85.4% of the sample. The newborns weighed 975.9 g on average (SD: 457.5). Twenty-four (57.1%) presented Apgar scores below 7 in the first minute and 21.4% in the fifth minute. Gestational age at diagnosis, birth weight and Apgar of the first minute proved to be variables significantly related to neonatal death (p values were: 0.008, 0.004, and 0.020, respectively). The Odds Ratio was 6.6, 25.3 and 13.8 for neonatal death, when the diagnosis was established at the 28th week, weight was

Manoel, Martins Neto; Francisco Herlânio Costa, Carvalho; Rosa Maria Salani, Mota; Carlos Augusto, Alencar Júnior.

2010-07-01

240

Perinatal outcome of growth restricted fetus with absent end diastolic umbilical blood flow: Case report  

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Introduction. Absent or reversed end-diastolic blood flow in the umbilical artery is usually associated with poor perinatal outcome and high perinatal mortality rate. Case report. We present the case of a pregnant woman with absent end-diastolic blood flow in the umbilical artery in the 27th week of pregnancy with initial restriction of fetal growth. All though it was more and more obvious that the fetal growth was hindered, the Doppler, cardiotocographic and biophysical parameters did not ge...

Tasi? Marija; Lili? Vekoslav; Miloševi? Jelena; Stefanovi? Milan; Anti? Vladimir

2010-01-01

 
 
 
 
241

Avaliação de influências sociais e econômicas sobre a pressão arterial de adolescentes de escolas públicas e privadas: um estudo epidemiológico / Assessment of social and economic influences on blood pressure of adolescents in public and private schools: an epidemiological study  

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Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese INTRODUÇÃO: Anteriormente, a alta prevalência de hipertensão arterial em alunos do Ensino Médio de Sorocaba, em São Paulo, foi descrita. Neste estudo, em nova amostra de alunos da mesma faixa etária, oriundos de escolas públicas e privadas, foi avaliado se as diferenças socioeconômicas e o modo de v [...] ida podem influenciar os valores da pressão arterial. MÉTODOS: Trata-se de um estudo epidemiológico, inserido entre as atividades de um trabalho comunitário, em que estudantes de Medicina fazem palestras para alunos do Ensino Médio, objetivando estimular hábitos de vida saudáveis e a prevenção primária da hipertensão arterial. Em amostra aleatória de 410 alunos do segundo ano do Ensino Médio (209 de escolas públicas e 201 de escolas privadas), foram determinados o peso, a altura e a pressão arterial, e foi aplicado um questionário epidemiológico e socioeconômico. RESULTADOS: Não há diferenças estatísticas entre os alunos das escolas públicas e privadas quanto à distribuição de sexo, ao índice de massa corporal (IMC), à pressão arterial sistólica e diastólica, à prevalência de hipertensão arterial (16,3%), à porcentagem de fumantes (5,9%), à atividade física regular e aos antecedentes familiares de hipertensão arterial. Nas escolas públicas há maior porcentagem de afro-descendentes, os alunos trabalham fora de casa com maior frequência e têm menor renda familiar. Nas escolas públicas e privadas, os homens têm maior prevalência de hipertensão arterial e a média da pressão arterial é maior que nas mulheres. O IMC tem correlação positiva com a pressão arterial sistólica e diastólica. CONCLUSÕES: A hipertensão arterial e outros fatores de risco cardiovasculares têm início precoce e necessitam de intervenções educativas para a prevenção primária. Fatores socioeconômicos não influenciam a pressão arterial na adolescência. Abstract in english INTRODUCTION: The high prevalence of hypertension in high school students in Sorocaba, São Paulo, Brazil, has already been described. In this study, within a new sample of high school students from public and private schools, we evaluated if socioeconomic and lifestyle influence on blood pressure va [...] lues. METHODS: This is an epidemiological study, which is part of the activities of a community-based work conducted by medical students. They give speeches to high school students aiming at stimulating a healthy lifestyle and primary prevention of hypertension. In a random sample of 410 students in junior high school (209 from public schools and 201 from private schools), we determined the weight, height, and blood pressure, furthermore, a questionnaire identifying epidemiological and socioeconomic status was applied. RESULTS: No statistical differences were found among students from public and private schools regarding the distribution of gender, body mass index (BMI), systolic and diastolic blood pressure, prevalence of hypertension (16.3%), percentage of smokers (5.9%), regular physical activity, and family history of hypertension. In public schools, there is a higher percentage of African descendents students and a higher percentage of students who also work due to low family income. Men from public and private schools have higher prevalence of hypertension, and their mean blood pressure is higher than in women. BMI has a positive correlation with systolic and diastolic blood pressure. CONCLUSIONS: Hypertension and other cardiovascular risk factors have an early beginning and require educational interventions for primary prevention. Socioeconomic factors do not affect blood pressure in adolescence.

Fernando Antonio de, Almeida; Henrique Pinheiro, Konigsfeld; Lígia Maria de Oliveira, Machado; Andréa Farias, Canadas; Evelyn Yuri Okumura, Issa; Roberto Hernandes, Giordano; Ricardo Augusto de Miranda, Cadaval.

2011-06-01

242

Avaliação de influências sociais e econômicas sobre a pressão arterial de adolescentes de escolas públicas e privadas: um estudo epidemiológico / Assessment of social and economic influences on blood pressure of adolescents in public and private schools: an epidemiological study  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese INTRODUÇÃO: Anteriormente, a alta prevalência de hipertensão arterial em alunos do Ensino Médio de Sorocaba, em São Paulo, foi descrita. Neste estudo, em nova amostra de alunos da mesma faixa etária, oriundos de escolas públicas e privadas, foi avaliado se as diferenças socioeconômicas e o modo de v [...] ida podem influenciar os valores da pressão arterial. MÉTODOS: Trata-se de um estudo epidemiológico, inserido entre as atividades de um trabalho comunitário, em que estudantes de Medicina fazem palestras para alunos do Ensino Médio, objetivando estimular hábitos de vida saudáveis e a prevenção primária da hipertensão arterial. Em amostra aleatória de 410 alunos do segundo ano do Ensino Médio (209 de escolas públicas e 201 de escolas privadas), foram determinados o peso, a altura e a pressão arterial, e foi aplicado um questionário epidemiológico e socioeconômico. RESULTADOS: Não há diferenças estatísticas entre os alunos das escolas públicas e privadas quanto à distribuição de sexo, ao índice de massa corporal (IMC), à pressão arterial sistólica e diastólica, à prevalência de hipertensão arterial (16,3%), à porcentagem de fumantes (5,9%), à atividade física regular e aos antecedentes familiares de hipertensão arterial. Nas escolas públicas há maior porcentagem de afro-descendentes, os alunos trabalham fora de casa com maior frequência e têm menor renda familiar. Nas escolas públicas e privadas, os homens têm maior prevalência de hipertensão arterial e a média da pressão arterial é maior que nas mulheres. O IMC tem correlação positiva com a pressão arterial sistólica e diastólica. CONCLUSÕES: A hipertensão arterial e outros fatores de risco cardiovasculares têm início precoce e necessitam de intervenções educativas para a prevenção primária. Fatores socioeconômicos não influenciam a pressão arterial na adolescência. Abstract in english INTRODUCTION: The high prevalence of hypertension in high school students in Sorocaba, São Paulo, Brazil, has already been described. In this study, within a new sample of high school students from public and private schools, we evaluated if socioeconomic and lifestyle influence on blood pressure va [...] lues. METHODS: This is an epidemiological study, which is part of the activities of a community-based work conducted by medical students. They give speeches to high school students aiming at stimulating a healthy lifestyle and primary prevention of hypertension. In a random sample of 410 students in junior high school (209 from public schools and 201 from private schools), we determined the weight, height, and blood pressure, furthermore, a questionnaire identifying epidemiological and socioeconomic status was applied. RESULTS: No statistical differences were found among students from public and private schools regarding the distribution of gender, body mass index (BMI), systolic and diastolic blood pressure, prevalence of hypertension (16.3%), percentage of smokers (5.9%), regular physical activity, and family history of hypertension. In public schools, there is a higher percentage of African descendents students and a higher percentage of students who also work due to low family income. Men from public and private schools have higher prevalence of hypertension, and their mean blood pressure is higher than in women. BMI has a positive correlation with systolic and diastolic blood pressure. CONCLUSIONS: Hypertension and other cardiovascular risk factors have an early beginning and require educational interventions for primary prevention. Socioeconomic factors do not affect blood pressure in adolescence.

Fernando Antonio de, Almeida; Henrique Pinheiro, Konigsfeld; Lígia Maria de Oliveira, Machado; Andréa Farias, Canadas; Evelyn Yuri Okumura, Issa; Roberto Hernandes, Giordano; Ricardo Augusto de Miranda, Cadaval.

243

Acute nitric oxide synthase inhibition and endothelin-1-dependent arterial pressure elevation  

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Full Text Available Key evidence that endogenous nitric oxide (NO inhibits the continuous, endothelin (ET-1-mediated drive to elevate arterial pressure includes demonstrations that ET-1 mediates a significant component of the pressure elevated by acute exposure to NO synthase (NOS inhibitors. This review examines the characteristics of this pressure elevation in order to elucidate potential mechanisms associated with the negative regulation of ET-1 by NO and, thereby, provide potential insight into the vascular pathophysiology underlying NO dysregulation. We surmise that the magnitude of the ET-1-dependent component of the NOS inhibitor-elevated pressure is 1 independent of underlying arterial pressure and other pressor pathways activated by the NOS inhibitors and 2 dependent on relatively higher NOS inhibitor dose, release of stored and de novo synthesized ET-1, and ETA receptor-mediated increased vascular resistance. Major implications of these conclusions include: 1 the marked variation of the ET-1-dependent component, i.e., from 0-100% of the pressure elevation, reflects the NO-ET-1 regulatory pathway. Thus, NOS inhibitor-mediated, ET-1-dependent pressure elevation in vascular pathophysiologies is an indicator of the level of compromised/enhanced function of this pathway; 2 NO is a more potent inhibitor of ET-1-mediated elevated arterial pressure than other pressor pathways, due in part to inhibition of intravascular pressure-independent release of ET-1. Thus, the ET-1-dependent component of pressure elevation in vascular pathophysiologies associated with NO dysregulation is of greater magnitude at higher levels of compromised NO.

RobertRapoport

2014-04-01

244

Cambios en la presión arterial en un grupo de voluntarios normotensos después del consumo de diferentes dosis de café filtrado / Changes in blood pressure in a group of normotense volunteers after consumption or different doses of filtered coffee  

Scientific Electronic Library Online (English)

Full Text Available SciELO Colombia | Language: Spanish Abstract in spanish No es clara la asociación entre el consumo de café y los cambios en los niveles de presión arterial; si bien algunos estudios muestran una correlación positiva, otros no logran confirmarla. El objetivo de este estudio fue determinar el cambio en los niveles de presión arterial en un grupo de volunta [...] rios normotensos sometidos al consumo de diferentes dosis de café filtrado. Se trata de un estudio prospectivo, clínico controlado, en el cual se conformaron cuatro grupos y se sometieron por un período de seis semanas al consumo de diferentes cantidades de café filtrado: el grupo uno no consumió café, el grupo dos consumió 200 mL, el tres 400 mL y el cuatro 600 mL. Antes y al final de la intervención, en cada sujeto se midieron los niveles de presión arterial; en el grupo control se midió la concentración de cafeína antes, durante y al final de la intervención. Los resultados mostraron grupos comparables por género, edad e índice de masa corporal, sin diferencias significativas en las condiciones basales. Después de la intervención, la presión arterial sistólica y diastólica no mostró diferencia intragrupos, excepto en el grupo cuatro en el cual disminuyó significativamente (p=0,006) la presión arterial diastólica. Entre grupos los cambios en los niveles de presión sistólica y diastólica no fueron significativos (p=0,510 y 0,430 respectivamente). En conclusión, el consumo de diferentes dosis de café filtrado no ocasionó en sujetos normotensos cambios significativos en los niveles de presión arterial; el grupo que se abstuvo de tomar café no mostró disminución significativa de la presión arterial. Abstract in english The association between coffee consumption and changes in blood pressure values is not clear yet. Although some studies show a positive correlation, others fail to confirm it. The aim of this study was to determine changes in blood pressure values in a group of normotense volunteers submitted to con [...] sumption of different doses of filtered coffee. This is a prospective clinical controlled study in which four groups were conformed and were submitted during a period of six weeks to consumption of different doses of filtered coffee: group one did not have coffee, group two consumed 200 mL, group three 400 mL and group four 600 mL. Blood pressure values were measured before and at the end of the intervention in each subject; in the control group coffeine concentration was measured before, during and at the end of the intervention. The results showed comparable groups by gender, age and body mass index, without significant differences in basal conditions. After the intervention, systolic and diastolic blood pressure did not show any difference between the groups, with the exception of group four in which diastolic blood pressure diminished significantly (p=0.006). Between the groups, the changes in systolic and diastolic blood pressure values were not significant (p=0.510 and 0.430 respectively). In conclusion, consumption of different doses of filtered coffee did not cause significant changes in blood pressure values; the group that did not have coffee did not show significant lowering of blood pressure values.

Gloria M, Agudelo; Claudia M, Velásquez; Olga L, Cardona; Mauricio, Duque; Myriam, Posada; Vanesa, Pineda; Leonor E, Suárez.

245

Cambios en la presión arterial en un grupo de voluntarios normotensos después del consumo de diferentes dosis de café filtrado Changes in blood pressure in a group of normotense volunteers after consumption or different doses of filtered coffee  

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Full Text Available No es clara la asociación entre el consumo de café y los cambios en los niveles de presión arterial; si bien algunos estudios muestran una correlación positiva, otros no logran confirmarla. El objetivo de este estudio fue determinar el cambio en los niveles de presión arterial en un grupo de voluntarios normotensos sometidos al consumo de diferentes dosis de café filtrado. Se trata de un estudio prospectivo, clínico controlado, en el cual se conformaron cuatro grupos y se sometieron por un período de seis semanas al consumo de diferentes cantidades de café filtrado: el grupo uno no consumió café, el grupo dos consumió 200 mL, el tres 400 mL y el cuatro 600 mL. Antes y al final de la intervención, en cada sujeto se midieron los niveles de presión arterial; en el grupo control se midió la concentración de cafeína antes, durante y al final de la intervención. Los resultados mostraron grupos comparables por género, edad e índice de masa corporal, sin diferencias significativas en las condiciones basales. Después de la intervención, la presión arterial sistólica y diastólica no mostró diferencia intragrupos, excepto en el grupo cuatro en el cual disminuyó significativamente (p=0,006 la presión arterial diastólica. Entre grupos los cambios en los niveles de presión sistólica y diastólica no fueron significativos (p=0,510 y 0,430 respectivamente. En conclusión, el consumo de diferentes dosis de café filtrado no ocasionó en sujetos normotensos cambios significativos en los niveles de presión arterial; el grupo que se abstuvo de tomar café no mostró disminución significativa de la presión arterial.The association between coffee consumption and changes in blood pressure values is not clear yet. Although some studies show a positive correlation, others fail to confirm it. The aim of this study was to determine changes in blood pressure values in a group of normotense volunteers submitted to consumption of different doses of filtered coffee. This is a prospective clinical controlled study in which four groups were conformed and were submitted during a period of six weeks to consumption of different doses of filtered coffee: group one did not have coffee, group two consumed 200 mL, group three 400 mL and group four 600 mL. Blood pressure values were measured before and at the end of the intervention in each subject; in the control group coffeine concentration was measured before, during and at the end of the intervention. The results showed comparable groups by gender, age and body mass index, without significant differences in basal conditions. After the intervention, systolic and diastolic blood pressure did not show any difference between the groups, with the exception of group four in which diastolic blood pressure diminished significantly (p=0.006. Between the groups, the changes in systolic and diastolic blood pressure values were not significant (p=0.510 and 0.430 respectively. In conclusion, consumption of different doses of filtered coffee did not cause significant changes in blood pressure values; the group that did not have coffee did not show significant lowering of blood pressure values.

Gloria M Agudelo

2008-12-01

246

Cambios en la presión arterial en un grupo de voluntarios normotensos después del consumo de diferentes dosis de café filtrado / Changes in blood pressure in a group of normotense volunteers after consumption or different doses of filtered coffee  

Scientific Electronic Library Online (English)

Full Text Available SciELO Colombia | Language: Spanish Abstract in spanish No es clara la asociación entre el consumo de café y los cambios en los niveles de presión arterial; si bien algunos estudios muestran una correlación positiva, otros no logran confirmarla. El objetivo de este estudio fue determinar el cambio en los niveles de presión arterial en un grupo de volunta [...] rios normotensos sometidos al consumo de diferentes dosis de café filtrado. Se trata de un estudio prospectivo, clínico controlado, en el cual se conformaron cuatro grupos y se sometieron por un período de seis semanas al consumo de diferentes cantidades de café filtrado: el grupo uno no consumió café, el grupo dos consumió 200 mL, el tres 400 mL y el cuatro 600 mL. Antes y al final de la intervención, en cada sujeto se midieron los niveles de presión arterial; en el grupo control se midió la concentración de cafeína antes, durante y al final de la intervención. Los resultados mostraron grupos comparables por género, edad e índice de masa corporal, sin diferencias significativas en las condiciones basales. Después de la intervención, la presión arterial sistólica y diastólica no mostró diferencia intragrupos, excepto en el grupo cuatro en el cual disminuyó significativamente (p=0,006) la presión arterial diastólica. Entre grupos los cambios en los niveles de presión sistólica y diastólica no fueron significativos (p=0,510 y 0,430 respectivamente). En conclusión, el consumo de diferentes dosis de café filtrado no ocasionó en sujetos normotensos cambios significativos en los niveles de presión arterial; el grupo que se abstuvo de tomar café no mostró disminución significativa de la presión arterial. Abstract in english The association between coffee consumption and changes in blood pressure values is not clear yet. Although some studies show a positive correlation, others fail to confirm it. The aim of this study was to determine changes in blood pressure values in a group of normotense volunteers submitted to con [...] sumption of different doses of filtered coffee. This is a prospective clinical controlled study in which four groups were conformed and were submitted during a period of six weeks to consumption of different doses of filtered coffee: group one did not have coffee, group two consumed 200 mL, group three 400 mL and group four 600 mL. Blood pressure values were measured before and at the end of the intervention in each subject; in the control group coffeine concentration was measured before, during and at the end of the intervention. The results showed comparable groups by gender, age and body mass index, without significant differences in basal conditions. After the intervention, systolic and diastolic blood pressure did not show any difference between the groups, with the exception of group four in which diastolic blood pressure diminished significantly (p=0.006). Between the groups, the changes in systolic and diastolic blood pressure values were not significant (p=0.510 and 0.430 respectively). In conclusion, consumption of different doses of filtered coffee did not cause significant changes in blood pressure values; the group that did not have coffee did not show significant lowering of blood pressure values.

Gloria M, Agudelo; Claudia M, Velásquez; Olga L, Cardona; Mauricio, Duque; Myriam, Posada; Vanesa, Pineda; Leonor E, Suárez.

2008-12-01

247

Radial Applanation Tonometry as an Adjuvant Tool in the Noninvasive Arterial Stiffness and Blood Pressure Assessment  

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Full Text Available Since antiquity, the human arterial pulse represents an important parameter in the clinical assessment. Besides being routinely assessed in the medical practice, such pulse is not observed in its completeness yet, once many of the data obtained through it cannot be evaluated using conventional methods. Taking into account such methods, the measurement of arterial blood pressure using sphygmomanometry, although broadly widespread in the assessment and follow-up of patients who require accompaniment of their cardiovascular status, is not able to properly guide about parameters related to the central hemodynamic status, the latter most strongly associated with cardiovascular risk. Such incapability is due to the centrifugal augmentation of the pressures taken at different points of the arterial bed, based on the properties of the closed arterial system through which the blood flow travels. In this context, methodologies capable of assessing central parameters estimated using the pulse wave analysis, such as applanation tonometry, represent a promising adjuvant for evaluating patients with cardiovascular diseases, by providing detailed information concerning hemodynamic parameters otherwise inaccessible. In this scenario, the present review focuses on the applanation tonometry and its assessment on the radial artery, highlighting the importance of this method in the cardiovascular assessment, as well as its relevance in the clinical practice, when determining parameters peripherally obtained capable of estimating the central hemodynamic status.

Lucas José Sá da Fonseca

2014-05-01

248

Impact of renal artery stent implantation on hypertension in patients with hemodialysis.  

Science.gov (United States)

The benefit from renal artery stent implantation to treat atherosclerotic renal artery stenosis (ARAS) is not well understood in hemodialysis patients. We sought to evaluate the effects of renal artery stenting on hypertension of hemodialysis patients. Renal artery stent implantation was successfully performed on eight hypertensive hemodialysis patients with ARAS (mean?±?SD, 66?±?10 years; men 6, women 2). Blood pressure was measured by automated oscillometric recordings just before hemodialysis. Mean values of the blood pressure, measured 12 times a month, were used for blood pressure analysis. Values of systolic blood pressure decreased at 6 months after renal artery stent implantation (162.6?±?29.7 to 121.1?±?23.3?mm Hg, p?=?0.0015). Values of diastolic blood pressure also decreased from 77.6?±?13.6 to 65.6?±?7.2?mm Hg (p?=?0.02). Renal artery stent implantation for ARAS had a beneficial effect on hypertension in hemodialysis patients. PMID:25075163

Hikita, Hiroyuki; Kojima, Keisuke; Kimura, Shigeki; Takahashi, Atsushi; Isobe, Mitsuaki

2014-06-01

249

Respuesta ortostática de la tensión arterial de pacientes con enfermedad de Parkinson inicial / Orthostatic response of blood pressure in patients with early Parkinson's disease  

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Full Text Available SciELO Mexico | Language: Spanish Abstract in spanish Objetivo: Evaluar la respuesta ortostática de la tensión arterial de forma no invasiva en pacientes con enfermedad de Parkinson inicial leve a moderada atendidos en el Instituto Nacional de Neurología y Neurocirugía. Método: Se realizó un estudio de corte transversal con grupo control. Se incluyeron [...] pacientes con enfermedad de Parkinson de menos de 5 años de evolución y severidad leve a moderada así como controles sanos. Se excluyeron sujetos con diabetes mellitus, hipertensión arterial o diagnóstico de disautonomía. Se realizaron mediciones de la tensión arterial en posición supina, y posteriormente a los3y5minde asumir bipedestación. Resultados: Se incluyeron 70 sujetos con enfermedad de Parkinson y 145 controles. No se encontraron diferencias estadísticamente significativas en género y edad entre ambos grupos. No hubo diferencias en el cambio de la tensión arterial sistólica entre los grupos a los 3 min pero sí a los 5min (p = 0.03). En el caso de la tensión diastólica existió diferencia entre ambos grupos a los 3 y 5min (p = 0.02 y p = 0.007). Conclusión: Los pacientes con enfermedad de Parkinson inicial presentan diferencias en la respuesta ortostática con respecto a controles sanos, siendo de mayor relevancia a los 5 min de bipedestación. Abstract in english Objective: To evaluate orthostatic blood pressure response in patients with early Parkinson's disease and mild to moderate disease treated at the National Institute of Neurology and Neurosurgery. Method: A cross-sectional study with control group was carried out. Patients with Parkinson's disease wi [...] th a disease duration of less than 5 years and mild to moderate severity along with healthy controls of the same age group were included. Those subjects with diabetes mellitus, hypertension or diagnosis of dysautonomia were excluded. Blood pressure was measured in supine position as well as after 3 and 5 min of standing. Results: Seventy subjects with Parkinson's disease and 145 controls were included. There were no statistically significant differences in gender and age between both groups. There was no difference in systolic blood pressure change between groups at 3 minutes but at 5 minutes a statistically significant difference was found (P = .03). For diastolic blood pressure a difference between both groups was present at three and five minutes (P = .02 and P = .007). Conclusion: Patients with early Parkinson's disease have differences in orthostatic responses compared to healthy controls, these differences are more relevant at 5 minutes of standing.

Mayela, Rodríguez-Violante; Amin, Cervantes-Arriaga; Daniela, García-Ibarra; Teresa, Corona.

250

Respuesta ortostática de la tensión arterial de pacientes con enfermedad de Parkinson inicial / Orthostatic response of blood pressure in patients with early Parkinson's disease  

Scientific Electronic Library Online (English)

Full Text Available SciELO Mexico | Language: Spanish Abstract in spanish Objetivo: Evaluar la respuesta ortostática de la tensión arterial de forma no invasiva en pacientes con enfermedad de Parkinson inicial leve a moderada atendidos en el Instituto Nacional de Neurología y Neurocirugía. Método: Se realizó un estudio de corte transversal con grupo control. Se incluyeron [...] pacientes con enfermedad de Parkinson de menos de 5 años de evolución y severidad leve a moderada así como controles sanos. Se excluyeron sujetos con diabetes mellitus, hipertensión arterial o diagnóstico de disautonomía. Se realizaron mediciones de la tensión arterial en posición supina, y posteriormente a los3y5minde asumir bipedestación. Resultados: Se incluyeron 70 sujetos con enfermedad de Parkinson y 145 controles. No se encontraron diferencias estadísticamente significativas en género y edad entre ambos grupos. No hubo diferencias en el cambio de la tensión arterial sistólica entre los grupos a los 3 min pero sí a los 5min (p = 0.03). En el caso de la tensión diastólica existió diferencia entre ambos grupos a los 3 y 5min (p = 0.02 y p = 0.007). Conclusión: Los pacientes con enfermedad de Parkinson inicial presentan diferencias en la respuesta ortostática con respecto a controles sanos, siendo de mayor relevancia a los 5 min de bipedestación. Abstract in english Objective: To evaluate orthostatic blood pressure response in patients with early Parkinson's disease and mild to moderate disease treated at the National Institute of Neurology and Neurosurgery. Method: A cross-sectional study with control group was carried out. Patients with Parkinson's disease wi [...] th a disease duration of less than 5 years and mild to moderate severity along with healthy controls of the same age group were included. Those subjects with diabetes mellitus, hypertension or diagnosis of dysautonomia were excluded. Blood pressure was measured in supine position as well as after 3 and 5 min of standing. Results: Seventy subjects with Parkinson's disease and 145 controls were included. There were no statistically significant differences in gender and age between both groups. There was no difference in systolic blood pressure change between groups at 3 minutes but at 5 minutes a statistically significant difference was found (P = .03). For diastolic blood pressure a difference between both groups was present at three and five minutes (P = .02 and P = .007). Conclusion: Patients with early Parkinson's disease have differences in orthostatic responses compared to healthy controls, these differences are more relevant at 5 minutes of standing.

Mayela, Rodríguez-Violante; Amin, Cervantes-Arriaga; Daniela, García-Ibarra; Teresa, Corona.

2013-06-01

251

Arterial blood oxygen saturation during blood pressure cuff-induced hypoperfusion  

International Nuclear Information System (INIS)

Pulse oximetry has been one of the most significant technological advances in clinical monitoring in the last two decades. Pulse oximetry is a non-invasive photometric technique that provides information about the arterial blood oxygen saturation (SpO2) and heart rate, and has widespread clinical applications. When peripheral perfusion is poor, as in states of hypovolaemia, hypothermia and vasoconstriction, oxygenation readings become unreliable or cease. The problem arises because conventional pulse oximetry sensors must be attached to the most peripheral parts of the body, such as finger, ear or toe, where pulsatile flow is most easily compromised. Pulse oximeters estimate arterial oxygen saturation by shining light at two different wavelengths, red and infrared, through vascular tissue. In this method the ac pulsatile photoplethysmographic (PPG) signal associated with cardiac contraction is assumed to be attributable solely to the arterial blood component. The amplitudes of the red and infrared ac PPG signals are sensitive to changes in arterial oxygen saturation because of differences in the light absorption of oxygenated and deoxygenated haemoglobin at these two wavelengths. From the ratios of these amplitudes, and the corresponding dc photoplethysmographic components, arterial blood oxygen saturation (SpO2) is estimated. Hence, the technique of pulse oximetry relies on the presence of adequate peripheral arterial pulsations, which are detecheral arterial pulsations, which are detected as photoplethysmographic (PPG) signals. The aim of this study was to investigate the effect of pressure cuff-induced hypoperfusion on photoplethysmographic signals and arterial blood oxygen saturation using a custom made finger blood oxygen saturation PPG/SpO2 sensor and a commercial finger pulse oximeter. Blood oxygen saturation values from the custom oxygen saturation sensor and a commercial finger oxygen saturation sensor were recorded from 14 healthy volunteers at various induced brachial pressures. Both pulse oximeters showed gradual decrease of saturations during induced hypoperfusion which demonstrate the direct relation between blood volumes (PPG amplitudes), arterial vessel stenosis and blood oxygen saturation. The custom made pulse oximeter was found to be more sensitive to SpO2 changes than the commercial pulse oximeter especially at high occluding pressures

252

The Effects of Cola Acuminata on Arterial Blood Pressure  

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Caffeine has been proven to be vasoactive and augments the release of calcium from sarcoplasmic reticulum. Interestingly, caffeine is the most active principle of Cola acuminata-commonly consumed in Nigeria. This study is designed to determine its effects on blood pressure using 20 Sprague dawley rats with an average weight of 150g. The animals were subdivided into 2 groups of 10 rats each (control and test groups). The control rats were fed with rat chow while the test groups were fed with s...

Igbinovia, E. N. S.; Ugwu, A. C.; Nwaopara, A. O.; Otamere, H. O.; Adisa, W. A.

2009-01-01

253

Resposta da pressão arterial ao esforço em adolescentes: influência do sobrepeso e obesidade Blood pressure response to physical exertion in adolescents: influence of overweight and obesity  

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Full Text Available FUNDAMENTO: A resposta aguda da pressão arterial ao esforço tem sido utilizada como indicador de risco para o desenvolvimento de hipertensão arterial. Os fatores associados com essa resposta precisam ser esclarecidos a fim de se intervir na prevenção da doença hipertensiva. OBJETIVO: Descrever o comportamento das variáveis cardiovasculares ao esforço agudo em adolescentes com excesso de peso, por meio de teste cardiopulmonar. MÉTODOS: A amostra foi constituída de 104 adolescentes (56 meninos e 48 meninas, divididos nos grupos de sobrepeso/obesos (GSO e eutróficos (GE. Foram aferidas variáveis antropométricas (peso, estatura e IMC, de composição corporal (dobra cutânea e variáveis hemodinâmicas de pressão arterial sistólica (PAS e diastólica (PAD e freqüência cardíaca (FC, no repouso e no esforço máximo do teste cardiopulmonar. RESULTADOS: No grupo masculino, identificaram-se maiores valores de pressão arterial sistólica de repouso para o GSO, quando comparados com o GE (113 ± 13 vs 106 ± 8 mmHg; p = 0,009, a PAS pré-exercício (120 ± 14 vs 109 ± 10 mmHg; p = 0,003 e de PAS na carga máxima de trabalho (156 ± 20 vs 146 ± 14 mmHg; p = 0,03. No grupo feminino, apenas a PAS pré-exercício foi superior no grupo de sobrepeso, quando isso foi comparado com as eutróficas (114 ± 11 vs 106 ± 10 mmHg; p = 0,009. CONCLUSÃO: A resposta pressórica durante o exercício foi mais exacerbada em adolescentes obesos quando comparada com àquela obtida em eutróficos, o que indica maior reatividade ao estresse físico.BACKGROUND: The acute blood pressure response to physical exertion has been used as an indicator of the risk of developing hypertension. The factors associated with this response need to be clarified for timely intervention in preventing hypertensive disease. OBJECTIVE: To describe the response of cardiovascular variables to acute physical exertion in overweight adolescents using cardiopulmonary exercise testing. METHODS: The sample consisted of 104 adolescents (56 boys and 48 girls, divided into two groups: the obese/overweight group (OOG and the eutrophic group (EG. The following variables were measured: anthropometric (weight, height, and BMI, body composition (skin fold thickness, as well as hemodynamic variables such as systolic arterial pressure (SAP, diastolic arterial pressure (DAP, and heart rate (HR, at rest and at maximal physical exertion during the cardiopulmonary test. RESULTS: In the male group, the greatest values of systolic arterial pressure at rest were recorded in the OOG as compared to the EG (113 ± 13 vs 106 ± 8 mmHg; p = 0.009, pre-exertion SAP (120 ± 14 vs 109 ± 10 mmHg; p = 0.003, and SAP during maximal exertion conditions (156 ± 20 vs 146 ± 14 mmHg; p = 0.03. In the female group, only pre-exertion SAP was higher in the overweight group as compared to the eutrophic girls (114 ± 11 vs 106 ± 10 mmHg; p = 0.009. CONCLUSION: The response of arterial blood pressure during physical exercise was most exacerbated in obese adolescents as compared to eutrophic teens, suggesting greater reactivity to physical exertion.

Luciana Carletti

2008-07-01

254

Resposta da pressão arterial ao esforço em adolescentes: influência do sobrepeso e obesidade / Blood pressure response to physical exertion in adolescents: influence of overweight and obesity  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese FUNDAMENTO: A resposta aguda da pressão arterial ao esforço tem sido utilizada como indicador de risco para o desenvolvimento de hipertensão arterial. Os fatores associados com essa resposta precisam ser esclarecidos a fim de se intervir na prevenção da doença hipertensiva. OBJETIVO: Descrever o com [...] portamento das variáveis cardiovasculares ao esforço agudo em adolescentes com excesso de peso, por meio de teste cardiopulmonar. MÉTODOS: A amostra foi constituída de 104 adolescentes (56 meninos e 48 meninas), divididos nos grupos de sobrepeso/obesos (GSO) e eutróficos (GE). Foram aferidas variáveis antropométricas (peso, estatura e IMC), de composição corporal (dobra cutânea) e variáveis hemodinâmicas de pressão arterial sistólica (PAS) e diastólica (PAD) e freqüência cardíaca (FC), no repouso e no esforço máximo do teste cardiopulmonar. RESULTADOS: No grupo masculino, identificaram-se maiores valores de pressão arterial sistólica de repouso para o GSO, quando comparados com o GE (113 ± 13 vs 106 ± 8 mmHg; p = 0,009), a PAS pré-exercício (120 ± 14 vs 109 ± 10 mmHg; p = 0,003) e de PAS na carga máxima de trabalho (156 ± 20 vs 146 ± 14 mmHg; p = 0,03). No grupo feminino, apenas a PAS pré-exercício foi superior no grupo de sobrepeso, quando isso foi comparado com as eutróficas (114 ± 11 vs 106 ± 10 mmHg; p = 0,009). CONCLUSÃO: A resposta pressórica durante o exercício foi mais exacerbada em adolescentes obesos quando comparada com àquela obtida em eutróficos, o que indica maior reatividade ao estresse físico. Abstract in english BACKGROUND: The acute blood pressure response to physical exertion has been used as an indicator of the risk of developing hypertension. The factors associated with this response need to be clarified for timely intervention in preventing hypertensive disease. OBJECTIVE: To describe the response of c [...] ardiovascular variables to acute physical exertion in overweight adolescents using cardiopulmonary exercise testing. METHODS: The sample consisted of 104 adolescents (56 boys and 48 girls), divided into two groups: the obese/overweight group (OOG) and the eutrophic group (EG). The following variables were measured: anthropometric (weight, height, and BMI), body composition (skin fold thickness), as well as hemodynamic variables such as systolic arterial pressure (SAP), diastolic arterial pressure (DAP), and heart rate (HR), at rest and at maximal physical exertion during the cardiopulmonary test. RESULTS: In the male group, the greatest values of systolic arterial pressure at rest were recorded in the OOG as compared to the EG (113 ± 13 vs 106 ± 8 mmHg; p = 0.009), pre-exertion SAP (120 ± 14 vs 109 ± 10 mmHg; p = 0.003), and SAP during maximal exertion conditions (156 ± 20 vs 146 ± 14 mmHg; p = 0.03). In the female group, only pre-exertion SAP was higher in the overweight group as compared to the eutrophic girls (114 ± 11 vs 106 ± 10 mmHg; p = 0.009). CONCLUSION: The response of arterial blood pressure during physical exercise was most exacerbated in obese adolescents as compared to eutrophic teens, suggesting greater reactivity to physical exertion.

Luciana, Carletti; Anabel Nunes, Rodrigues; Anselmo José, Perez; Dalton Valentim, Vassallo.

255

Limitação funcional e claudicação intermitente: impacto das medidas de pressão arterial / Functional limitation and intermittent claudication: impact of blood pressure measurements  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese FUNDAMENTO: A hipertensão arterial é importante fator de risco para Doença Arterial Obstrutiva Periférica dos Membros Inferiores (DAOMI). Entretanto, a correlação entre pressão arterial e Pressão de Pulso (PP) com a gravidade da DAOMI e o prejuízo funcional decorrente dessa doença ainda não está bem [...] estabelecida na população brasileira. OBJETIVO: Verificar se há correlação entre pressão arterial, PP, gravidade da DAOMI e capacidade funcional de pacientes com DAOMI sintomática. MÉTODOS: FORAM avaliados 65 pacientes (62,2 ± 8,1 anos; 56,9% do sexo masculino), divididos em dois grupos: pressão arterial normal (A) e elevada (B). A gravidade da DAOMI foi avaliada por meio do Índice Tornozelo-Braquial (ITB) e a capacidade funcional, pelas distâncias total e livre de dor percorridas em teste de marcha. RESULTADOS: O grupo A foi constituído por 17 (26,1%) pacientes. A Pressão Arterial Sistólica (PAS), diastólica e a PP foram, respectivamente, 125,4 ± 11,7; 74,5 ± 9,1 e 50,9 ±10,0 mmHg, para o grupo A, e 160,7 ± 19,6; 90,0 ± 12,2 e 70,7 ± 20,2 mmHg, para o grupo B. O ITB foi significativamente menor no grupo B (0,66 ± 0,12 vs 0,57 ± 0,13, p 40 mmHg percorreram menores distâncias. CONCLUSÃO: A PAS e a PP correlacionaram-se de forma significativa com as distâncias percorridas em teste de marcha, sugerindo que sejam marcardores clínicos da limitação da capacidade funcional em pacientes com DAOMI sintomática. Abstract in english BACKGROUND: Arterial hypertension is an important risk factor for Lower-Limb Occlusive Arterial Disease (LLOAD). However, the correlation between blood pressure and pulse pressure (PP) with LLOAD severity and functional impairment resulting from this disease is not well established in the Brazilian [...] population. OBJECTIVE: To verify whether there is a correlation between blood pressure, PP, LLOAD severity and functional capacity in patients with symptomatic LLOAD. METHODS: A total of 65 patients (62.2 + 8.1 years, 56.9% males) were evaluated. They were divided into two groups: normal (A) and high (B) blood pressure. LLOAD severity was assessed using the ankle-brachial index (ABI) and functional capacity by the total and pain-free walking distance at the 6-minute walking test (6MWT). RESULTS: Group A consisted of 17 (26.1%) patients. The systolic (SBP), diastolic blood pressure (DBP), and PP were, respectively, 125.4 ±11.7, 74.5 ± 9.1 and 50.9 ± 10.0 mmHg in group A and 160.7 ± 19.6, 90.0 ± 12.2 and 70.7 ± 20.2 mmHg in group B. The ABI was significantly lower in group B (0.66 ± 0.12 vs. 0.57 ± 0.13, p 40 mmHg walked shorter distances. CONCLUSION: SBP and PP significantly correlated with the distances walked in the 6MWT, suggesting they are clinical markers of functional capacity impairment in patients with symptomatic LLOAD.

Rita de Cássia Gengo e, Silva; Cassiana Rosa Galvão, Giribela; Nelson, Wolosker; Fernanda Marciano, Consolim-Colombo.

256

Limitação funcional e claudicação intermitente: impacto das medidas de pressão arterial / Functional limitation and intermittent claudication: impact of blood pressure measurements  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese FUNDAMENTO: A hipertensão arterial é importante fator de risco para Doença Arterial Obstrutiva Periférica dos Membros Inferiores (DAOMI). Entretanto, a correlação entre pressão arterial e Pressão de Pulso (PP) com a gravidade da DAOMI e o prejuízo funcional decorrente dessa doença ainda não está bem [...] estabelecida na população brasileira. OBJETIVO: Verificar se há correlação entre pressão arterial, PP, gravidade da DAOMI e capacidade funcional de pacientes com DAOMI sintomática. MÉTODOS: FORAM avaliados 65 pacientes (62,2 ± 8,1 anos; 56,9% do sexo masculino), divididos em dois grupos: pressão arterial normal (A) e elevada (B). A gravidade da DAOMI foi avaliada por meio do Índice Tornozelo-Braquial (ITB) e a capacidade funcional, pelas distâncias total e livre de dor percorridas em teste de marcha. RESULTADOS: O grupo A foi constituído por 17 (26,1%) pacientes. A Pressão Arterial Sistólica (PAS), diastólica e a PP foram, respectivamente, 125,4 ± 11,7; 74,5 ± 9,1 e 50,9 ±10,0 mmHg, para o grupo A, e 160,7 ± 19,6; 90,0 ± 12,2 e 70,7 ± 20,2 mmHg, para o grupo B. O ITB foi significativamente menor no grupo B (0,66 ± 0,12 vs 0,57 ± 0,13, p 40 mmHg percorreram menores distâncias. CONCLUSÃO: A PAS e a PP correlacionaram-se de forma significativa com as distâncias percorridas em teste de marcha, sugerindo que sejam marcardores clínicos da limitação da capacidade funcional em pacientes com DAOMI sintomática. Abstract in english BACKGROUND: Arterial hypertension is an important risk factor for Lower-Limb Occlusive Arterial Disease (LLOAD). However, the correlation between blood pressure and pulse pressure (PP) with LLOAD severity and functional impairment resulting from this disease is not well established in the Brazilian [...] population. OBJECTIVE: To verify whether there is a correlation between blood pressure, PP, LLOAD severity and functional capacity in patients with symptomatic LLOAD. METHODS: A total of 65 patients (62.2 + 8.1 years, 56.9% males) were evaluated. They were divided into two groups: normal (A) and high (B) blood pressure. LLOAD severity was assessed using the ankle-brachial index (ABI) and functional capacity by the total and pain-free walking distance at the 6-minute walking test (6MWT). RESULTS: Group A consisted of 17 (26.1%) patients. The systolic (SBP), diastolic blood pressure (DBP), and PP were, respectively, 125.4 ±11.7, 74.5 ± 9.1 and 50.9 ± 10.0 mmHg in group A and 160.7 ± 19.6, 90.0 ± 12.2 and 70.7 ± 20.2 mmHg in group B. The ABI was significantly lower in group B (0.66 ± 0.12 vs. 0.57 ± 0.13, p 40 mmHg walked shorter distances. CONCLUSION: SBP and PP significantly correlated with the distances walked in the 6MWT, suggesting they are clinical markers of functional capacity impairment in patients with symptomatic LLOAD.

Rita de Cássia Gengo e, Silva; Cassiana Rosa Galvão, Giribela; Nelson, Wolosker; Fernanda Marciano, Consolim-Colombo.

2012-02-01

257

Blood pressure variability in conscious spontaneously hypertensive rats during endothelin A receptor inhibition.  

Science.gov (United States)

Spontaneously hypertensive rats (SHR) and normotensive Wistar rats were treated with the endothelin(A) (ET(A)) receptor antagonist BQ-123 16.4 nmol/kg.min i.v. at an infusion rate of 25 microl/min for 50 min. Blood pressure was measured in the femoral artery with a Gould/Statham P23ID transducer connected to the computerized data acquisition system Biopac MP100WS. Values of interpulse interval, systolic, diastolic and mean arterial pressure were determined in every heart cycle. Spectrum analysis of systolic, diastolic and mean arterial pressure and interpulse interval variabilities was performed using fast Fourier transform algorithm. In contrast to normotensive rats, BQ-123 infusion in SHR increased mid-frequency band in systolic, diastolic and mean arterial pressure (p < 0.05). The baroreflex sensitivity obtained by the alpha-coefficient in the mid-frequency region (square root of the relation PMFIPI/PMFSAP in msec/mmHg) did not differ between Wistar and SHR before and during BQ-123 administration. Endogenous endothelin acting via endothelin(A) receptors modulates the effects of the sympathetic nervous system on the variations of systolic, diastolic and mean arterial pressure in the hypertensive state. This interrelation between endogenous endothelin and the sympathetic nervous system is not dependent on the arterial baroreflex and is most likely to be realized locally on the vessel level. PMID:14988738

Girchev, R; Markova, P

2004-01-01

258

Speed Modulation of the Continuous-Flow Total Artificial Heart to Simulate a Physiologic Arterial Pressure Waveform  

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This study demonstrated the concept of using speed modulation in a continuous-flow total artificial heart (CFTAH) to shape arterial pressure waveforms and to adjust pressure pulsatility. A programmable function generator was used to determine the optimum pulsatile speed profile. Three speed profiles (sinusoidal, rectangular, and optimized [a profile optimized for generation of a physiologic arterial pressure waveform]) were evaluated using the CFTAH mock circulatory loop. Hemodynamic paramete...

Shiose, Akira; Nowak, Kathleen; Horvath, David J.; Massiello, Alex L.; Golding, Leonard A. R.; Fukamachi, Kiyotaka

2010-01-01

259

Current clinical applications of spectral tissue Doppler echocardiography (E/E' ratio as a noninvasive surrogate for left ventricular diastolic pressures in the diagnosis of heart failure with preserved left ventricular systolic function  

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Full Text Available Abstract Congestive heart failure with preserved left ventricular systolic function has emerged as a growing epidemic medical syndrome in developed countries, which is characterized by high morbidity and mortality rates. Rapid and accurate diagnosis of this condition is essential for optimizing the therapeutic management. The diagnosis of congestive heart failure is challenging in patients presenting without obvious left ventricular systolic dysfunction and additional diagnostic information is most commonly required in this setting. Comprehensive Doppler echocardiography is the single most useful diagnostic test recommended by the ESC and ACC/AHA guidelines for assessing left ventricular ejection fraction and cardiac abnormalities in patients with suspected congestive heart failure, and non-invasively determined basal or exercise-induced pulmonary capillary hypertension is likely to become a hallmark of congestive heart failure in symptomatic patients with preserved left ventricular systolic function. The present review will focus on the current clinical applications of spectral tissue Doppler echocardiography used as a reliable noninvasive surrogate for left ventricular diastolic pressures at rest as well as during exercise in the diagnosis of heart failure with preserved left ventricular systolic function. Chronic congestive heart failure, a disease of exercise, and acute heart failure syndromes are characterized by specific pathophysiologic and diagnostic issues, and these two clinical presentations will be discussed separately.

Roux Emmanuel

2007-03-01

260

Pulse transit time as a surrogate measure of changes in systolic arterial pressure in children during sleep.  

Science.gov (United States)

Pulse transit time has been proposed as a surrogate measure of systolic arterial pressure, as it is dependent upon arterial stiffness. Past research has shown that pulse transit time has a significant inverse relationship to systolic arterial pressure in adults; however, studies in children are limited. This study aimed to explore the relationship between systolic arterial pressure and pulse transit time in children during sleep. Twenty-five children (13.1 ± 1.6 years, 48% male) underwent overnight polysomnography (PSG) with a simultaneous recording of continuous systolic arterial pressure and photoplethysmography. Pulse transit time was calculated as the time delay between the R-wave peak of the electrocardiogram (ECG) to the 50% point of the upstroke of the corresponding photoplethysmography waveform; 500 beats of simultaneous systolic arterial pressure and pulse transit time were analysed in each sleep stage for each child. Pulse transit time was normalized to each subject's mean wake pulse transit time. The ability of pulse transit time to predict systolic arterial pressure change was determined by linear mixed-effects modelling. Significant negative correlations between pulse transit time and systolic arterial pressure were found for individual children for each sleep stage [mean correlations for cohort: non-rapid eye movement (NREM) sleep 1 and 2 r = -0.57, slow wave sleep (SWS) r = -0.76, REM r = -0.65, P < 0.01 for all]. Linear mixed-model analysis demonstrated that changes in pulse transit time were a significant predictor of changes in systolic arterial pressure for each sleep stage (P < 0.001). The model of pulse transit time-predicted systolic arterial pressure closely tracked actual systolic arterial pressure changes over time. This study demonstrated that pulse transit time was accurate in tracking systolic arterial pressure changes over time. Thus, the use of pulse transit time as a surrogate measure of changes in systolic arterial pressure in children is a valid, non-invasive and inexpensive method with many potential applications. PMID:24605887

Vlahandonis, Anna; Biggs, Sarah N; Nixon, Gillian M; Davey, Margot J; Walter, Lisa M; Horne, Rosemary S C

2014-08-01

 
 
 
 
261

Comparação entre os valores da pressão arterial central e braquial de pacientes com hipertensão arterial submetidos à cineangiocoronariografia / Comparison between the central and brachial blood pressure values in patients with hypertension undergoing cineangiocoronarography  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese INTRODUÇÃO: Durante o envelhecimento, a pressão arterial sistólica (PS) e a pressão de pulso (PP) se elevam gradativamente, consequente à redução da elasticidade arterial. A medida da pressão arterial sistêmica (PAS) aferida na raiz da aorta tem sido considerada como um determinante independente da [...] mortalidade cardiovascular superior aos valores PAS braquial. OBJETIVO: Comparar os valores da PAS central e PAS braquial em portadores de hipertensão arterial nas diversas faixas etárias. MÉTODO: Avaliamos a PAS central na raiz da aorta e a PAS braquial no braço esquerdo pelo método oscilométrico em 244 pacientes com hipertensão submetidos à cineangiocoronariografia. Foram constituídos cinco grupos de pacientes: Grupo I, 39-49 anos, n = 36; Grupo II, 50-59 anos, n = 67; Grupo III, 60-69 anos, n = 69; Grupo IV, 70-79 anos, n = 46; e o Grupo V, > 80 anos, n = 26. RESULTADOS: Ao comparar a PS central versus PS braquial, foi possível encontrar significância a partir dos 50 anos de vida. Não encontramos diferença estatística entre a pressão diastólica central versus diastólica braquial, exceto nos pacientes com idade entre 60-69 anos. Na comparação entre a PP central e PP braquial, observamos que a PP central foi significativamente maior (entre 11 a 15 mmHg) em todos os pacientes com idade superior a 50 anos. CONCLUSÃO: Com o envelhecimento, os valores das PS e de PP, aferidas diretamente na raiz da aorta, são superiores àqueles obtidos por método indireto na artéria braquial. Essas diferenças são significantes a partir dos 50 anos de idade. Abstract in english INTRODUCTION: Systolic blood pressure (SP) and pulse pressure (PP) rise gradually during the aging process as a consequence of a reduction in arterial elasticity. The measure of systemic arterial pressure (SAP) taken at the root of the aorta has been considered an independent determinant of cardiova [...] scular mortality superior to the values of brachial SAP. AIM: To compare the values of SAP central to those of braquial SAP in patients of different age brackets who have systemic hypertension. METHOD: We evaluated the central SAP at the root of the aorta and the brachial SAP in the left arm using the ocillometric method 244 hypertensive patients who had been submitted to cineangiocoronarography. Five groups of patients were constituted: Group I, 39-49 years-old (y.o.), n = 36; Group II, 50-59 y.o., n = 67; Group III, 60-69 y.o., n = 69; Group IV, 70-79 y.o., n = 46; Group V, > 80 y.o., n = 26. RESULTS: When central SP was compared to brachial SP, it was possible to find significance in patients who were 50 y.o and upwards. It was not possible to find a statistical difference between central diastolic pressure and brachial except in patients between the ages of 60-69 y.o. When comparing central to brachial PP, we observed that central PP was significantly greater (between 11 and 15 mmHg) in all patient above the age of 50 y.o. CONCLUSION: In older people, the values of SP and PP, taken directly at the root of the aorta, are superior to those obtained by indirect means from the brachial artery. These differences are significant from the age of 50 y.o. onwards.

Bruno Bordin, Pelazza; Cesar Augusto Saldanha, Rosa; Sebastião Rodrigues, Ferreira Filho.

262

Comparação entre os valores da pressão arterial central e braquial de pacientes com hipertensão arterial submetidos à cineangiocoronariografia / Comparison between the central and brachial blood pressure values in patients with hypertension undergoing cineangiocoronarography  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese INTRODUÇÃO: Durante o envelhecimento, a pressão arterial sistólica (PS) e a pressão de pulso (PP) se elevam gradativamente, consequente à redução da elasticidade arterial. A medida da pressão arterial sistêmica (PAS) aferida na raiz da aorta tem sido considerada como um determinante independente da [...] mortalidade cardiovascular superior aos valores PAS braquial. OBJETIVO: Comparar os valores da PAS central e PAS braquial em portadores de hipertensão arterial nas diversas faixas etárias. MÉTODO: Avaliamos a PAS central na raiz da aorta e a PAS braquial no braço esquerdo pelo método oscilométrico em 244 pacientes com hipertensão submetidos à cineangiocoronariografia. Foram constituídos cinco grupos de pacientes: Grupo I, 39-49 anos, n = 36; Grupo II, 50-59 anos, n = 67; Grupo III, 60-69 anos, n = 69; Grupo IV, 70-79 anos, n = 46; e o Grupo V, > 80 anos, n = 26. RESULTADOS: Ao comparar a PS central versus PS braquial, foi possível encontrar significância a partir dos 50 anos de vida. Não encontramos diferença estatística entre a pressão diastólica central versus diastólica braquial, exceto nos pacientes com idade entre 60-69 anos. Na comparação entre a PP central e PP braquial, observamos que a PP central foi significativamente maior (entre 11 a 15 mmHg) em todos os pacientes com idade superior a 50 anos. CONCLUSÃO: Com o envelhecimento, os valores das PS e de PP, aferidas diretamente na raiz da aorta, são superiores àqueles obtidos por método indireto na artéria braquial. Essas diferenças são significantes a partir dos 50 anos de idade. Abstract in english INTRODUCTION: Systolic blood pressure (SP) and pulse pressure (PP) rise gradually during the aging process as a consequence of a reduction in arterial elasticity. The measure of systemic arterial pressure (SAP) taken at the root of the aorta has been considered an independent determinant of cardiova [...] scular mortality superior to the values of brachial SAP. AIM: To compare the values of SAP central to those of braquial SAP in patients of different age brackets who have systemic hypertension. METHOD: We evaluated the central SAP at the root of the aorta and the brachial SAP in the left arm using the ocillometric method 244 hypertensive patients who had been submitted to cineangiocoronarography. Five groups of patients were constituted: Group I, 39-49 years-old (y.o.), n = 36; Group II, 50-59 y.o., n = 67; Group III, 60-69 y.o., n = 69; Group IV, 70-79 y.o., n = 46; Group V, > 80 y.o., n = 26. RESULTS: When central SP was compared to brachial SP, it was possible to find significance in patients who were 50 y.o and upwards. It was not possible to find a statistical difference between central diastolic pressure and brachial except in patients between the ages of 60-69 y.o. When comparing central to brachial PP, we observed that central PP was significantly greater (between 11 and 15 mmHg) in all patient above the age of 50 y.o. CONCLUSION: In older people, the values of SP and PP, taken directly at the root of the aorta, are superior to those obtained by indirect means from the brachial artery. These differences are significant from the age of 50 y.o. onwards.

Bruno Bordin, Pelazza; Cesar Augusto Saldanha, Rosa; Sebastião Rodrigues, Ferreira Filho.

2012-09-01

263

Skin perfusion pressure measured with a photo sensor in an air-filled plastic balloon: validity and reproducibility on the lower leg in normal subjects and patients suspected of obliterative arterial disease  

DEFF Research Database (Denmark)

An inflatable small plastic bag including a photo sensor was constructed for measurement of skin perfusion pressure avoiding the rim of the photo sensor over bony and tendineous surfaces of the tibia below the knee, at the ankle, and on the dorsal forefoot. Compression was obtained using a conical blood pressure cuff with continuous decrease from suprasystolic arm pressure. The validity of skin perfusion pressure with the new device was compared to that of isotope washout below the knee in normal subjects and in patients with an ischemic forefoot with acceptable agreement. The method had a high reproducibility within and between days in normal subjects. Compared to systolic arterial pressure measured using a strain gauge with a cuff on the ankle in normal subjects and patients with intermittent claudication the new device showed blood pressure in the skin closer to the diastolic pressure. The new pressure device thus had acceptable validity and reproducibility for estimation of the skin perfusion pressure andcan be used on bony and tendineous sites on the lower limb in regions where critical wound healing is frequent, e.g. ankle and forefoot.

Nielsen, Steen Levin; Nielsen, Anne Lerberg

2011-01-01

264

Correlação entre as pressões parciais de co2 no ar expirado e no sangue arterial, em porcas submetidas a pneumoperitônio Correlation between the expired air co2 partial pressure and the arterial co2 pressure in pigs under pneumoperitonium  

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Full Text Available OBJETIVO: As cirurgias realizadas por via laparoscópica, que utilizam CO2 para realização do pneumoperitônio, cursam com hipercarbia. Esta alteração pode ser estimada pela pressão parcial de CO2 no ar expirado. Este trabalho foi realizado com a finalidade de determinar se há correlação entre pressão parcial de CO2 arterial e pressão parcial de CO2 no ar expirado nas cirurgias por via laparoscópica. MÉTODO: Distribuíram-se 20 porcas em dois grupos: sem pneumoperitônio e com pneumoperitônio de 12 mmHg de pressão intra-abdominal. Foram medidas a pressão endotraqueal, saturação arterial de O2, pressão parcial de CO2 no ar expirado, pH e pressão parcial de CO2 arteriais. RESULTADOS: Após a realização do pneumoperitônio foi encontrado aumento significativo da pressão endotraqueal, da pressão parcial de CO2 no ar expirado e pressão parcial de CO2 arterial. CONCLUSÕES: Apesar de ter ocorrido aumento nas pressões parciais de CO2 tanto arterial quanto no ar expirado, não houve correlação linear entre elas, não se podendo estimar em cirurgias por via laparoscópica a pressão parcial de CO2 arterial pela pressão parcial de CO2 no ar expirado.OBJECTIVE: The use of CO2 to promote pneumoperitoneun in laparoscopic surgeries causes hipercarbia. Expired air CO2 partial pressure may estimate this change.The purpose of this study is to determine whether there is a correlation between arterial CO2 partial pressure and expired air CO2 partial pressure during laparoscopic surgeries. METHODS: Twenty female pigs were assigned to two groups: one without pneumoperitoneun and another with a 12 mmHg intra abdominal pressure. Endotracheal pressure, arterial CO2 saturation, expired air CO2 partial pressure, pH and arterial CO2 partial pressure were determined. RESULTS: After performing pneumoperitoneun there was a marked increase in endotracheal pressure, expired air CO2 partial pressure and arterial CO2 partial pressure. CONCLUSIONS: In spite of the increase in both CO2 arterial partial pressure and expired air partial pressure, there was no linear correlation between them, so that it is not possible to estimate arterial CO2 partial pressure by the expired air CO2 partial pressure during laparoscopic surgeries.

Antonio Carlos Valezi

2003-06-01

265

Regulation of optic nerve head blood flow during combined changes in intraocular pressure and arterial blood pressure.  

Science.gov (United States)

In the choroid, there is evidence that blood flow does not only depend on ocular perfusion pressure (OPP), but also on absolute mean arterial pressure (MAP) and intraocular pressure (IOP). The present study included 40 healthy subjects to investigate whether such behavior is also found in the optic nerve head (ONH). The ONH blood flow (ONHBF) was studied using laser Doppler flowmetry during a separate increase in IOP and MAP as well as during a combined elevation. Mean arterial pressure was increased by isometric exercise and IOP by the suction method. During both, the change in ONHBF was less pronounced than the change in OPP indicating autoregulation. Correlation analysis was performed for the combined experiments after pooling all data according to IOP and MAP values. A correlation between ONHBF and MAP was found at IOPs ?25?mm?Hg (P25?mm?Hg (P=0.79). Optic nerve head blood flow and IOP were significantly correlated (P<0.001), and ONHBF was only slightly dependent on MAP. The data of the present study indicate a complex regulation of ONHBF during combined changes in MAP and IOP. Our results may be compatible with myogenic mechanisms underlying autoregulation, and indicate better ONHBF regulation during an increase in MAP than during an increase in IOP. PMID:23921903

Boltz, Agnes; Schmidl, Doreen; Werkmeister, René M; Lasta, Michael; Kaya, Semira; Palkovits, Stefan; Told, Reinhard; Napora, Katarzyna J; Popa-Cherecheanu, Alina; Garhöfer, Gerhard; Schmetterer, Leopold

2013-12-01

266

Arterial blood oxygen saturation during blood pressure cuff-induced hypoperfusion  

Science.gov (United States)

Pulse oximetry has been one of the most significant technological advances in clinical monitoring in the last two decades. Pulse oximetry is a non-invasive photometric technique that provides information about the arterial blood oxygen saturation (SpO2) and heart rate, and has widespread clinical applications. When peripheral perfusion is poor, as in states of hypovolaemia, hypothermia and vasoconstriction, oxygenation readings become unreliable or cease. The problem arises because conventional pulse oximetry sensors must be attached to the most peripheral parts of the body, such as finger, ear or toe, where pulsatile flow is most easily compromised. Pulse oximeters estimate arterial oxygen saturation by shining light at two different wavelengths, red and infrared, through vascular tissue. In this method the ac pulsatile photoplethysmographic (PPG) signal associated with cardiac contraction is assumed to be attributable solely to the arterial blood component. The amplitudes of the red and infrared ac PPG signals are sensitive to changes in arterial oxygen saturation because of differences in the light absorption of oxygenated and deoxygenated haemoglobin at these two wavelengths. From the ratios of these amplitudes, and the corresponding dc photoplethysmographic components, arterial blood oxygen saturation (SpO2) is estimated. Hence, the technique of pulse oximetry relies on the presence of adequate peripheral arterial pulsations, which are detected as photoplethysmographic (PPG) signals. The aim of this study was to investigate the effect of pressure cuff-induced hypoperfusion on photoplethysmographic signals and arterial blood oxygen saturation using a custom made finger blood oxygen saturation PPG/SpO2 sensor and a commercial finger pulse oximeter. Blood oxygen saturation values from the custom oxygen saturation sensor and a commercial finger oxygen saturation sensor were recorded from 14 healthy volunteers at various induced brachial pressures. Both pulse oximeters showed gradual decrease of saturations during induced hypoperfusion which demonstrate the direct relation between blood volumes (PPG amplitudes), arterial vessel stenosis and blood oxygen saturation. The custom made pulse oximeter was found to be more sensitive to SpO2 changes than the commercial pulse oximeter especially at high occluding pressures.

Kyriacou, P. A.; Shafqat, K.; Pal, S. K.

2007-10-01

267

Arterial blood oxygen saturation during blood pressure cuff-induced hypoperfusion  

Energy Technology Data Exchange (ETDEWEB)

Pulse oximetry has been one of the most significant technological advances in clinical monitoring in the last two decades. Pulse oximetry is a non-invasive photometric technique that provides information about the arterial blood oxygen saturation (SpO{sub 2}) and heart rate, and has widespread clinical applications. When peripheral perfusion is poor, as in states of hypovolaemia, hypothermia and vasoconstriction, oxygenation readings become unreliable or cease. The problem arises because conventional pulse oximetry sensors must be attached to the most peripheral parts of the body, such as finger, ear or toe, where pulsatile flow is most easily compromised. Pulse oximeters estimate arterial oxygen saturation by shining light at two different wavelengths, red and infrared, through vascular tissue. In this method the ac pulsatile photoplethysmographic (PPG) signal associated with cardiac contraction is assumed to be attributable solely to the arterial blood component. The amplitudes of the red and infrared ac PPG signals are sensitive to changes in arterial oxygen saturation because of differences in the light absorption of oxygenated and deoxygenated haemoglobin at these two wavelengths. From the ratios of these amplitudes, and the corresponding dc photoplethysmographic components, arterial blood oxygen saturation (SpO{sub 2}) is estimated. Hence, the technique of pulse oximetry relies on the presence of adequate peripheral arterial pulsations, which are detected as photoplethysmographic (PPG) signals. The aim of this study was to investigate the effect of pressure cuff-induced hypoperfusion on photoplethysmographic signals and arterial blood oxygen saturation using a custom made finger blood oxygen saturation PPG/SpO{sub 2} sensor and a commercial finger pulse oximeter. Blood oxygen saturation values from the custom oxygen saturation sensor and a commercial finger oxygen saturation sensor were recorded from 14 healthy volunteers at various induced brachial pressures. Both pulse oximeters showed gradual decrease of saturations during induced hypoperfusion which demonstrate the direct relation between blood volumes (PPG amplitudes), arterial vessel stenosis and blood oxygen saturation. The custom made pulse oximeter was found to be more sensitive to SpO{sub 2} changes than the commercial pulse oximeter especially at high occluding pressures.

Kyriacou, P A [School of Engineering and Mathematical Sciences, City University, London EC1V 0HB (United Kingdom); Shafqat, K [School of Engineering and Mathematical Sciences, City University, London EC1V 0HB (United Kingdom); Pal, S K [St Andrew' s Centre for Plastic Surgery and Burns, Broomfield Hospital, Chelmsford, CM1 7ET (United Kingdom)

2007-10-15

268

Surgical and histopathological effects of topical Ankaferd hemostat on major arterial vessel injury related to elevated intra-arterial blood pressure  

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Full Text Available Objective: The aim of this study was to assess the surgical and histopathological hemostatic effects of topical Ankaferd blood stopper (ABS on major arterial vessel injury related to elevated intra-arterial blood pressure in an experimental rabbit model.Materials and Methods: The study included 14 New Zealand rabbits. ABS was used to treat femoral artery puncture on 1 side in each animal and the other untreated side served as the control. Likewise, for abdominal aortic puncture, only 50% of the aortic injuries received topical liquid ABS and the others did not (control. The experiment was performed under conditions of normal arterial blood pressure and was repeated with a 50% increase in blood pressure. Histopathological analysis was performed in all of the studied animals.Results: Mean bleeding time in the control femoral arteries was 105.0±18.3 s, versus 51.4±9.8 s (p<0.05 in those treated with ABS. Mean blood loss from the punctured control femoral arteries was 5.0±1.5 mg and 1.6±0.4 mg from those treated with ABS (p<0.05. Histopathological examination of the damaged arterial structures showed that ABS induced red blood cell aggregates.Conclusion: ABS administered to experimental major arterial vessel injury reduced both bleeding time and blood loss under conditions of normal and elevated intra-arterial blood pressure. ABS-induced erythroid aggregation was prominent at the vascular tissue level. These findings will inform the design of future experimental and clinical studies on the anti-bleeding and vascular repairing effects of the novel hemostatic agent ABS.

A. Tulga Ulus

2011-09-01

269

Effect of Noise Pollution on Arterial Blood Pressure and Heart Pulse Rate of Workers in the Hospitals of Nablus City-West Bank  

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Full Text Available This research is studying noise pollution effects on the healthcare professionals in Nablus city hospitals. The arterial systolic and diastolic blood pressure (SBP and DBP and heart pulse rate were measured for 95 workers (55 males and 40 females in the selected hospitals of Nablus city. The ages of the sample workers were ranging from 20 to 73 year. The Sound Pressure Level (SPL values were first measured in all studied hospitals and were found to be high compared to the recommended value, 45.0 dB(A in the daytime. The difference between means of SBP, DBP and HPR before and after work are 6.335 (mmHg of SBP, 5.108 (mmHg of DBP and 5.305 of HPR (beatmin, respectively. In this study SBP, DBP and HPR are correlated positively (p-value < 0.050 with the occupational noise levels in all studied hospitals. In addition, the Pearson coefficient correlation (R value of SBP, DBP and HPR in all selected hospitals are correlated positively. Moreover, significant correlation was found between mean values of SBP, DBP and HPR with the duration of employment and age.

I.R. Ashqer

2013-01-01

270

Pressão arterial elevada, excesso de peso e obesidade abdominal em crianças e adolescentes / High blood pressure, overweigth and abdominal obesity in children and adolescents  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese O objetivo deste estudo foi verificar a frequência de pressão arterial elevada em meninos e meninas de 10 a 16 anos de idade, analisando sua associação com o excesso de peso corporal e a obesidade abdominal. Foram avaliadas 764 crianças e adolescentes (365 meninos e 399 meninas) provenientes de cinc [...] o escolas da rede pública de Curitiba. Avaliaram-se a estatura, o peso corporal, a circunferência abdominal e as pressões arteriais sistólica e diastólica de repouso. Foram utilizados o teste t de Student e Qui-Quadrado. Para todas as análises considerou-se p Abstract in english This study was to investigate the frequency of elevated blood pressure in boys and girls aged 10-16 years, and its association with overweight and abdominal obesity. A total of 764 children and adolescents (365 boys and 399 girls) from five public schools of Curitiba City had their height, weight, w [...] aist circumference, resting systolic and diastolic blood pressure measured. Body mass index (kg/m²) was classified in accordance with national reference, for age and gender. Student T-test, Chi-squared Test were calculated. For all analysis, the level of significance was set at p

Deise Cristiane, Moser; Gerusa Eisfeld, Milano; Lilian Messias Sampaio, Brito; Ana Cláudia Kapp, Titski; Neiva, Leite.

271

Pulse pressure and pulse pressure index:prediction for and correlation with the severity of coronary artery lesion in patients with coronary artery disease  

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Full Text Available Objective To investigate the correlation between pulse pressure(PP,pulse pressure index(PPI and the severity of coronary artery lesion in patients with CAD,and evaluate the significance of PP and PPI in predicting CAD.Methods The data of 9847 patients who had undergone coronary angiography were collected.The positive coronary angiography(stenosed major vessels ? 50% served as a diagnostic standard of CAD.CAD severity was assessed by Gensini score,and the number of stenosed arteries was counted.Relationship between PP,PPI and the severity of CAD was evaluated by both single factor analysis and multivariate binary logistic regression analysis.Results The CAD patients were found to have higher PP(54.63±15.82 vs 49.74±14.27,P < 0.001 and PPI(0.40±0.07 vs 0.38±0.07,P < 0.001.Furthermore,the severity of CAD were associated with increased PP and PPI.Binary logistic regression analysis showed that PPI was a prominent predictor of the CAD(OR=4.921,95%CI 2.241~10.808,P < 0.001.Conclusion The levels of PP and PPI are significantly correlated with CAD;PPI is the most prominent predictor in diagnosis of CAD.

Lei ZHANG

2011-04-01

272

Exercise-Echocardiography–Derived Pulmonary Artery Pressure Slope in Borderline and Mild to Moderate Pulmonary Arterial Hypertension  

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Full Text Available Objective: Examine pulmonary artery systolic pressure (PASP response to exercise in isolated borderline and mild to moderate pulmonary arterial hypertension (PAH.Methods: Doppler stress echocardiography was performed in 32 healthy volunteers with resting PASP of 29 mm Hg or less, 39 with resting PASP between 30 and 40 mm Hg, and 7 with resting PASP between 41 and less than 60 mm Hg. All subjects had otherwise normal echocardiograms.Results: Rate of increase in PASP with exercise was positively associated with resting PASP (P 0.001, increased age (P 0.001, and estrogen use among women (P = 0.001. On multivariate analysis, PASP slope was independently related (P = 0.03 to resting PASP and inversely associated with exercise time (P 0.001.Conclusions: Patients with borderline and mild to moderate resting PAH have an exaggerated PASP response to exercise. PASP slope is a strong independent predictor of exercise time. Outcome studies are needed to determine the prognostic significance of this finding.

Naser M. Ammash

2008-01-01

273

[Does this patient have hypertension? Different methodologies in the measurement of arterial pressure].  

Science.gov (United States)

Recommendations on the techniques for the measurement of hypertension have been published by WHO and the International Society of Hypertension. In order to assess the impact of these recommendations on the clinical practice among physicians, we have conducted a survey using a self reported questionnaire, among 211 hospital internists, 51 hospital cardiologists and 153 general practitioners (GPs). Large differences in the technique for the measurement of blood pressure were recorded within each group of specialists, whereas internists, cardiologists and GPs did not differ as groups. About half of the internists and cardiologists, and about two thirds of GPs reported they usually record the diastolic blood pressure at the fourth Korotkoff phase, while the others use the fifth phase. There was also disagreement on the patient position, sitting or lying, during blood pressure measurement. Physicians dealing with diagnosis and treatment of hypertension do not follow the international Society guidelines. Such differences may partly explain the inadequate control of hypertension in the general population and the increase in the prevalence of heart failure. PMID:12677776

Vancheri, Federico; Alletto, Maurizio; Sidoti, Paola

2003-03-01

274

Validade de um monitor digital de pulso para mensuração de pressão arterial em comparação com um esfigmomanômetro de mercúrio Validity of a wrist digital monitor for blood pressure measurement in comparison to a mercury sphygmomanometer  

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Full Text Available FUNDAMENTO: Medidas válidas da pressão arterial, em situações clínicas e na comunidade, são essenciais para a monitoração dessa variável em nível populacional. OBJETIVO: Avaliar a validade de um monitor digital de pulso para mensuração da pressão arterial em adolescentes, em comparação com um esfigmomanômetro de mercúrio. MÉTODOS: Um estudo de validação foi realizado na cidade de Pelotas, região sul do Brasil. A pressão arterial foi medida duas vezes, utilizando-se dois esfigmomanômetros diferentes: um aparelho digital de pulso OMRON e um aparelho de mesa BD de mercúrio. Metade da amostra foi medida primeiro através do manômetro digital e depois pelo de mercúrio, enquanto a outra metade foi avaliada na ordem inversa. A concordância entre as duas medidas foi avaliada através do método de Bland & Altman. RESULTADOS: 120 adolescentes com idade entre 14 e 15 anos foram incluídos no estudo (50% de cada sexo. A pressão sistólica média entre os meninos foi de 113,7 mmHg (DP 14,2 usando o manômetro de mercúrio e 115,5 mmHg (DP 15,2 usando o aparelho digital. Os valores equivalentes para a pressão diastólica foram 61,5 mmHg (DP 9,9 e 69,6 mmHg (10,2, respectivamente. Entre as meninas, a pressão sistólica média foi de 104,7 mmHg (DP 10,1 usando o manômetro de mercúrio e 102,4 mmHg (DP 11.9 usando o aparelho digital. Os valores equivalentes para a pressão diastólica foram 60,0 mmHg (DP 10,4 e 65,7 mmHg (DP 7,7, respectivamente. CONCLUSÕES: O manômetro digital apresentou alta concordância com o manômetro de mercúrio para medir a pressão arterial sistólica. A concordância foi menor para a pressão arterial diastólica. O uso de equações de correção pode ser uma alternativa para estudos utilizando esse monitor digital de pulso em adolescentes.BACKGROUND: Valid measurements of blood pressure, both at clinical and community settings, are essential for monitoring this variable at the population level. OBJECTIVE: To evaluate the validity of a wrist digital monitor for measuring blood pressure among adolescents in comparison to a mercury sphygmomanometer. METHODS: A validation study was carried out in the city of Pelotas, Southern Brazil. Blood pressure was measured twice using two different sphygmomanometers; an OMRON wrist digital and a desktop BD mercury one. Half of the sample was measured first with the digital manometer and subsequently with the mercury one, whereas the remaining half was evaluated in the opposite order. Agreement between both measures was evaluated using the Bland and Altman method. RESULTS: 120 adolescents aged 14 to 15 years were included (50% of each sex. Mean systolic blood pressure among boys was 113.7 mmHg (SD 14.2 when using the mercury manometer and 115.5 mmHg (SD 15.2 when using the digital one. Equivalent values for diastolic blood pressure were 61.5 mmHg (SD 9.9 and 69.6 mmHg (10.2, respectively. Among girls, the mean systolic blood pressure was 104.7 mmHg (SD 10.1 when using the mercury manometer and 102.4 mmHg (SD 11.9 when using the digital device. Values for diastolic blood pressure were 60.0 mmHg (SD 10.4 and 65.7 mmHg (SD 7.7, respectively. CONCLUSIONS: The digital device showed a high level of agreement with the mercury manometer when measuring systolic blood pressure. The level of agreement was lower for diastolic blood pressure. The use of correction equations may be an alternative for studies using this wrist digital monitor in adolescent patients.

Ana M. B. Menezes

2010-03-01

275

Model Predictive Control of Drug Infusion System for Mean Arterial Pressure Regulation of Critical Care Patients  

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Full Text Available Patients recovering in critical care units are continuously monitored for their hemodynamic states and accordingly given proper medication. The widely monitored hemodynamic variable is the Mean Arterial Pressure (MAP, which is regulated by infusion of vasoactive drugs like Sodium Nitroprusside (SNP. Presently, physicians check the patients’ MAP at regular intervals. This task is time-consuming and if automated, allows the physicians to attend to other critical parameters, which cannot be measured. Automation of the drug infusion based on the MAP would lead to continuous regulation of the hemodynamic variable enabling speedier recovery. This study attempts to automate the regulation of the drug infusion system using a model predictive controller. The controller’s performance was tested for three types of patient models. The controller tracks the set point changes and maintains the mean arterial pressure within the required values.

S.A. Nirmala

2014-05-01

276

A model for the genesis of arterial pressure Mayer waves from heart rate and sympathetic activity.  

Science.gov (United States)

Both theoretic models and cross-spectral analyses suggest that an oscillating sympathetic nervous outflow generates the low-frequency arterial pressure fluctuations termed Mayer waves. Fluctuations in heart rate also have been suggested to relate closely to Mayer waves, but empiric models have not assessed the joint causative influences of heart rate and sympathetic activity. Therefore, we constructed a model based simply upon the hemodynamic equation derived from Ohm's Law. With this model, we determined time relations and relative contributions of heart rate and sympathetic activity to the genesis of arterial pressure Mayer waves. We assessed data from eight healthy young volunteers in the basal state and in a high sympathetic state known to produce concurrent increases in sympathetic nervous outflow and Mayer wave amplitude. We fit the Mayer waves (0.05-0.20 Hz) in mean arterial pressure by the weighted sum of leading oscillations in heart rate and sympathetic nerve activity. This model of our data showed heart rate oscillations leading by 2-3.75 s were responsible for almost half of the variance in arterial pressure (basal R2 = 0.435 +/- 0.140, high sympathetic R2= 0.438 +/- 0.180). Surprisingly, sympathetic activity (lead 0-5 s) contributed only modestly to the explained variance in Mayer waves during either sympathetic state (basal: delta R2 = 0.046 +/- 0.026; heightened: delta R2 = 0.085 +/- 0.036). Thus, it appears that heart rate oscillations contribute to Mayer waves in a simple linear fashion, whereas sympathetic fluctuations contribute little to Mayer waves in this way. Although these results do not exclude an important vascular sympathetic role, they do suggest that additional factors, such as sympathetic transduction into vascular resistance, modulate its influence. PMID:11515803

Myers, C W; Cohen, M A; Eckberg, D L; Taylor, J A

2001-08-13

277

Response of blood pressure after percutaneous transluminal renal artery angioplasty and stenting  

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AIM: To evaluate the short and intermediate term outcome of percutaneous transluminal renal artery angioplasty (PTRA) and stenting particularly on blood pressure (BP) control and renal function and to evaluate predictors of poor BP response after successful PTRA and stenting. METHODS: We conducted a prospective analysis of all patients who underwent PTRA and stenting in our institute between August 2010 to September 2012. A total number of 86 patients were underwent PTRA and renal stenting. S...

Prajapati, Jayesh S.; Jain, Sharad R.; Hasit Joshi; Shaurin Shah; Kamal Sharma; Sibasis Sahoo; Kapil Virparia; Ashok Thakkar

2013-01-01

278

Mechanisms of Inhaled Fine Particulate Air Pollution–induced Arterial Blood Pressure Changes  

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Background: Epidemiologic studies suggest a positive association between fine particulate matter and arterial blood pressure, but the results have been inconsistent. Objectives: We investigated the effect of ambient particles on systemic hemodynamics during a 5-hr exposure to concentrated ambient air particles (CAPs) or filtered air (FA) in conscious canines. Methods: Thirteen dogs were repeatedly exposed via permanent tracheostomy to CAPs (358.1 ± 306.7 ?g/m\\(^3\\), mean ± SD) or FA in a c...

Bartoli, Carlo R.; Wellenius, Gregory A.; Akiyama, Ichiro; Lee, Lani M.; Okabe, Kazunori; Diaz, Edgar; Lawrence, Joy E.; Coull, Brent Andrew; Verrier, Richard Leonard; Godleski, John Joseph

2008-01-01

279

Long-term regulation of arterial blood pressure by hypothalamic nuclei: some critical questions.  

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1. The long-term level of arterial pressure is dependent on the relationship between arterial pressure and the urinary output of salt and water, which, in turn, is affected by a number of factors, including renal sympathetic nerve activity (RSNA). In the present brief review, we consider the mechanisms within the brain that can influence RSNA, focusing particularly on hypothalamic mechanisms. 2. The paraventricular nucleus (PVN) in the hypothalamus has major direct and indirect connections with the sympathetic outflow and there is now considerable evidence that tonic activation of the PVN sympathetic pathway contributes to the sustained increased level of RSNA that occurs in conditions such as heart failure and neurogenic hypertension. The tonic activity of PVN sympathetic neurons, in turn, depends upon the balance of excitatory and inhibitory inputs. A number of neurotransmitters and neuromodulators are involved in these tonic excitatory and inhibitory effects, including glutamate, GABA, angiotensin II and nitric oxide. 3. The dorsomedial hypothalamic nucleus (DMH) also exerts a powerful influence over sympathetic activity, including RSNA, via synapses with sympathetic nuclei in the medulla and, possibly, also other brainstem regions. The DMH sympathetic pathway is an important component of the phasic sympathoexcitatory responses associated with acute stress, but there is no evidence that it is an important component of the central pathways that produce long-term changes in arterial pressure. Nevertheless, it is possible that repeated episodic activation of this pathway could lead to vascular hypertrophy and, thus, sustained changes in vascular resistance and arterial pressure. 4. Recent studies have reactivated the old debate concerning the possible role of the baroreceptor reflex in the long-term regulation of sympathetic activity. Therefore, central resetting of the baroreceptor-sympathetic reflex may be an important component of the mechanisms causing sustained changes in RSNA. However, little is known about the cellular mechanisms that could cause such resetting. PMID:15854152

Dampney, R A L; Horiuchi, J; Killinger, S; Sheriff, M J; Tan, P S P; McDowall, L M

2005-01-01

280

Aspects of the continuous clinical measurement of arterial blood pressure and cardiac output  

International Nuclear Information System (INIS)

In this paper the authors try to classify circulatory measurements as to certain characteristics such as ''activeness'', ''invasivenesss'', etc. Next they turn to defining some fundamental measurements in the blood circulation and focus attention on the continuous measurement of systemic arterial pressure and flow to finally emphasize the inaccuracy of clinical cardiac output methods. The conclusion is that clinical circulatory measurement methods have accuracies at least an order of magnitude worse than common physical methods used in electrical or mechanical engineering. (Auth.)

 
 
 
 
281

The arterial load in pulmonary hypertension  

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Full Text Available The anatomical differences between the pulmonary and systemic arterial system are the main cause of the difference in distribution of compliance. In the pulmonary arterial system compliance is distributed over the entire arterial system, and stands at the basis of the constancy of the RC-time. This distribution depends on the number of peripheral vessels, which is ?8–10 times more in the pulmonary system than the systemic tree. In the systemic arterial tree the compliance is mainly located in the aorta (80% of total compliance in thoracic-abdominal aorta. The constant RC-time in the pulmonary bed results in proportionality of systolic and diastolic pressure with mean pressure and, in turn, in the constant ratio of oscillatory and mean power.

A. Vonk-Noordegraaf

2010-09-01

282

Medida da pressão arterial em crianças e adolescentes: recomendações das diretrizes de hipertensão arterial e prática médica atual / Blood pressure measurement in children and adolescents: guidelines of high blood pressure recommendations and current clinical practice  

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Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese OBJETIVO: Identificar, em crianças e adolescentes (7 a 17 anos, rede pública e privada de ensino), a freqüência de indivíduos já submetidos à medida da pressão arterial (MPA), o número de vezes, os locais em que foi realizada a aferição e o resultado informado. MÉTODOS: Estudo transversal. Amostrage [...] m por conglomerados em 40 escolas, nível fundamental e médio, sorteadas. Cálculo da amostra baseado na prevalência esperada de HAS em crianças e adolescentes. Protocolo: questionário sobre realização prévia de MPA (em caso afirmativo, quantas vezes, quando foi a última medida, o local e o resultado da medida) e duas MPA. Variáveis independentes: sexo, faixa etária, classe econômica, escola pública ou privada. RESULTADOS: Amostra constituída de 1253 estudantes 1215 responderam ao questionário (97%) 531 do sexo masculino média de 12,4 ± 3 anos. Prevalência de HAS: 7,7% 348 estudantes (29%) já haviam medido a PA (54% 1 vez 35% 2 a 4 vezes 11% 5 ou mais) 53% há menos de 1 ano. Posto de Saúde, residência, hospital e consultório foram os locais mais mencionados (27%, 16%, 15% e 14%, respectivamente). Houve associação significante entre prévia MPA com faixa etária de 15 a 17 anos, classes econômicas A e B e ser estudante de escola privada. CONCLUSÃO: Apesar das recomendações, há baixa freqüência de MPA (29%) em crianças e adolescentes, demonstrando que a mesma não foi ainda incorporada na prática clínica. Abstract in english OBJECTIVE: To determine, in a school-based sample of children and adolescents, aged from 7 to 17 years, of both gender, in public and private schools, the frequency of students already submitted to blood pressure measure. METHODS: A cross-sectional study was carried out, sampling from a population p [...] ool of elementary and middle schools, randomly selected. The sample was calculated based on the expected prevalence of hypertension for the age group. Data were collected through a questionnaire. Blood pressure was measured twice and hypertension was defined as mean systolic and/or diastolic blood pressure over the 95th percentile. Independent variables studied: sex; age groups; economic status; public/private school. RESULTS: The final sample included 1253 students. The response rate was 97%: 1215 students; 531 males; mean age 12,4±3 years (236 from 7 to 9 years; 638 from 10 to 14 years; 341 from 15 to 17 years). Prevalence of hypertension was 7.7%; 348 students (29%) were already submitted to blood pressure measures (54% once; 35% 2 to 4 times; 11% 5 or more times). High economic status, private school and adolescent group were significantly associated to previous blood pressure measure. CONCLUSION: Despite of pediatric consensus statements and guidelines recommendations about importance of blood pressure measure at every examination after age 3 years, there is a very low frequency of this practice (29%) in children and adolescents.

Maria Alayde Mendonça da, Silva; Ivan Romero, Rivera; Maria Goretti Barbosa de, Souza; Antonio Carlos de Camargo, Carvalho.

283

Frecuencia de la hipertensión arterial y su relación con algunas variables clínicas en pacientes con diabetes mellitus tipo 2 / High blood pressure frequency and its relation to some clinical variables in patients diagnosed with type 2 diabetes mellitus  

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Full Text Available SciELO Cuba | Language: Spanish Abstract in spanish Se realizó un estudio descriptivo transversal con 300 pacientes diabéticos tipo 2 ingresados en el Centro de Atención al Diabético de Bayamo, Granma, en el período comprendido entre octubre de 2007 y mayo de 2008, con el objetivo de conocer la frecuencia de hipertensión arterial y su relación con al [...] gunas variables clínicas en estos casos. Se revisaron las historias clínicas de cada uno de ellos para obtener datos de los aspectos siguientes: edad, sexo, color de la piel, hábitos tóxicos, edad al comienzo de la diabetes, estado nutricional, circunferencia de la cintura, tensión arterial y complicaciones crónicas de la diabetes. Se encontró hipertensión arterial en 210 pacientes (70 %); de ellos, 57 (27,1 %) presentaron hipertensión sistólica aislada, 39 (18,5 %) hipertensión diastólica, y 114 (54,4 %) hipertensión sistodiastólica. La hipertensión arterial se presentó desde el inicio de la diabetes en el 62,9 %. El 76,1 % de los pacientes hipertensos tenían sobrepeso u obesidad (P=0,0557). Resultó significativa la asociación entre la hipertensión arterial y la cardiopatía isquémica (p= 0,0117). En relación con el ictus y la insuficiencia arterial periférica, aunque la mayoría de los casos eran hipertensos, no llegó a ser estadísticamente significativo (p= 0,8261, p= 0,8600). El 71,1 % de los pacientes con retinopatía diabética y el 75 % con nefropatía diabética eran hipertensos (p= 0,8261, p= 0,8600). Se concluye que la hipertensión arterial tiene una elevada incidencia en los pacientes con diabetes mellitas tipo 2, porque está presente en un porcentaje importante desde el diagnóstico de la diabetes y se asocia significativamente a la presencia de cardiopatía isquémica. Abstract in english A cross-sectional and descriptive study was conducted in 300 patients with type 2 diabetes admitted in Diabetes Care Center of Bayamo, Granma province between October, 2007 and May, 2008 to know the high blood pressure frequency and its relation to some clinical variables in these cases. Medical rec [...] ords of each patient were reviewed to obtain data on the following features: age, sex, skin color, toxic habits, arterial pressure, and chronic complications of diabetes. High blood pressure was present in 210 patients (70 %), from them 57 (27.1 %) had isolated systolic hypertension, 39 (18.5 %) diastolic hypertension, and 114 (54.4 %) systolic-diastolic hypertension. Arterial hypertension was present from onset of diabetes in 62.9 %. The 76.1 % of hypertensive patients had overweight or obesity (p= 0.0557). The relationship was significant between arterial hypertension and ischemic heart disease (p = 0.0117). With regard to ictus and peripheral arterial failure, although most of cases were hypertensive, there was not statistic significance (p= 0.8261, p= 0.8600). The 71,1 % of patients presenting with diabetic retinopathy and the 75 % with diabetic nephropathy were hypertensive (p= 0.8261, p= 0.8600). We conclude that arterial hypertension shows a high incidence in patients with type 2 diabetes mellitus due to its presence in a significant percentage from the diabetes diagnosis and it is markedly associated with presence of ischemic heart disease.

Eduardo, Valdés Ramos; Niurka, Bencosme Rodríguez.

284

Frecuencia de la hipertensión arterial y su relación con algunas variables clínicas en pacientes con diabetes mellitus tipo 2 High blood pressure frequency and its relation to some clinical variables in patients diagnosed with type 2 diabetes mellitus  

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Full Text Available Se realizó un estudio descriptivo transversal con 300 pacientes diabéticos tipo 2 ingresados en el Centro de Atención al Diabético de Bayamo, Granma, en el período comprendido entre octubre de 2007 y mayo de 2008, con el objetivo de conocer la frecuencia de hipertensión arterial y su relación con algunas variables clínicas en estos casos. Se revisaron las historias clínicas de cada uno de ellos para obtener datos de los aspectos siguientes: edad, sexo, color de la piel, hábitos tóxicos, edad al comienzo de la diabetes, estado nutricional, circunferencia de la cintura, tensión arterial y complicaciones crónicas de la diabetes. Se encontró hipertensión arterial en 210 pacientes (70 %; de ellos, 57 (27,1 % presentaron hipertensión sistólica aislada, 39 (18,5 % hipertensión diastólica, y 114 (54,4 % hipertensión sistodiastólica. La hipertensión arterial se presentó desde el inicio de la diabetes en el 62,9 %. El 76,1 % de los pacientes hipertensos tenían sobrepeso u obesidad (P=0,0557. Resultó significativa la asociación entre la hipertensión arterial y la cardiopatía isquémica (p= 0,0117. En relación con el ictus y la insuficiencia arterial periférica, aunque la mayoría de los casos eran hipertensos, no llegó a ser estadísticamente significativo (p= 0,8261, p= 0,8600. El 71,1 % de los pacientes con retinopatía diabética y el 75 % con nefropatía diabética eran hipertensos (p= 0,8261, p= 0,8600. Se concluye que la hipertensión arterial tiene una elevada incidencia en los pacientes con diabetes mellitas tipo 2, porque está presente en un porcentaje importante desde el diagnóstico de la diabetes y se asocia significativamente a la presencia de cardiopatía isquémica.A cross-sectional and descriptive study was conducted in 300 patients with type 2 diabetes admitted in Diabetes Care Center of Bayamo, Granma province between October, 2007 and May, 2008 to know the high blood pressure frequency and its relation to some clinical variables in these cases. Medical records of each patient were reviewed to obtain data on the following features: age, sex, skin color, toxic habits, arterial pressure, and chronic complications of diabetes. High blood pressure was present in 210 patients (70 %, from them 57 (27.1 % had isolated systolic hypertension, 39 (18.5 % diastolic hypertension, and 114 (54.4 % systolic-diastolic hypertension. Arterial hypertension was present from onset of diabetes in 62.9 %. The 76.1 % of hypertensive patients had overweight or obesity (p= 0.0557. The relationship was significant between arterial hypertension and ischemic heart disease (p = 0.0117. With regard to ictus and peripheral arterial failure, although most of cases were hypertensive, there was not statistic significance (p= 0.8261, p= 0.8600. The 71,1 % of patients presenting with diabetic retinopathy and the 75 % with diabetic nephropathy were hypertensive (p= 0.8261, p= 0.8600. We conclude that arterial hypertension shows a high incidence in patients with type 2 diabetes mellitus due to its presence in a significant percentage from the diabetes diagnosis and it is markedly associated with presence of ischemic heart disease.

Eduardo Valdés Ramos

2009-12-01

285

Fiabilidade da medição da Tensão Arterial: revisão teórica La fiabilidad de la medida de presión arterial: revisión teórica Validity of arterial blood pressure measurement: theoretical review  

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Full Text Available A hipertensão arterial é um dos problemas de saúde pública mais importantes, sobretudo nos países desenvolvidos. É razoavelmente comum, facilmente diagnosticada e tem prognóstico reservado quando não tratada. Efectuou-se a pesquisa através das bases de dados EBSCO (Academic Search Premier, Sport diskus e a Medline, utilizando as palavras/ expressões- chave: “validation, accuracy, blood pressure measurement, reproducibility, sphygmomanometer, mercury, oscillometer e dinamap”. Os critérios de selecção basearam-se na pertinência, metodologia e data mais recente de elaboração. O instrumento considerado gold standart é o Esfigmomanómetro (EM; contudo, o mercúrio é tóxico para o ambiente, pelo que surgiu a necessidade da sua substituição por instrumentos com outra tecnologia. Além disso, acredita-se que 50% dos EM não estão em condições de serem utilizados. Braçadeiras menores que o desejável sobrestimam a Tensão Arterial (TA. Acredita-se também que 23% dos profissionais de saúde nunca tenham calibrado os seus instrumentos e que 40% não se recorde da data em que o fez; em 2/3 tal procedimento tinha ocorrido há mais de um ano, apesar de ser simples e pouco dispendioso. Recomenda-se uma calibração anual.La hipertensión es uno de los problemas de salud pública más importantes, sobre todo en los países desarrollados. Es bastante común, fácil de diagnosticar y tiene pronóstico reservado si no es tratada. Se llevó a cabo una investigación a través de las bases de datos EBSCO (Academic Search Premier, Sport diskus e a Medline, utilizando las palabras/expresiones clave: “validation, accuracy, blood pressure measurement, reproducibility, sphygmomanometer, mercury, oscillometer e dinamap”. Los criterios de selección se basaron en la pertinencia, la metodología y la fecha más reciente de elaboración. El instrumento considerado gold standart es el esfigmómetro (EM; sin embargo, el mercurio es tóxico para el medio ambiente, de ahí que surgiera la necesidad de su sustitución por instrumentos con otra tecnología. Además, se cree que el 50% de EM no está en condiciones de ser utilizado. Las abrazaderas menores de lo deseable sobrestiman la tensión arterial (TA. También se cree que el 23% de los profesionales de la salud nunca ha calibrado sus instrumentos y que el 40% no se acuerda de la fecha en la que lo ha hecho; 2/3 habían hecho esta prueba hace más de un año a pesar de ser simple y poco dispendiosa. Se recomienda una calibración anual.Arterial hypertension is one of the most important public health problems, especially in developed countries. It is reasonably common, easy to diagnose and has a limited prognosis when not treated. The research was done using the keywords: validation, accuracy, blood pressure measurement, reproducibility, sphygmomanometer, mercury, oscillometer e dinamap” in “Academic Search Premier, Sport diskus and Medline”; selecting the articles by methodology, relevance and publication date. The “gold standard” instrument is the sphygmomanometer; however, mercury is toxic, and so it must be substituted by other technology. In addition, 50% of sphygmomanometers are not in good condition for clinical use. Cuffs smaller than necessary over-estimate arterial blood pressure. It seems that 23% of health professionals have never calibrated the sphygmomanometer and 40% of the others did not remember when they did this; in 2/3 this situation has continued for longer than one year, despite being cheap and simple. Annual calibration is recommended.

Mónica Santos

2010-07-01

286

Estudo da pressão arterial pelo método indireto oscilométrico (petmap®) em cães domésticos não anestesiados / Study of blood pressure by the indirect oscillometric method (petmap®) in domestic unanesthetized dogs  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese O estudo das pressões arteriais sistólica, média, diastólica e da frequência cardíaca, pelo método indireto oscilométrico (petmap®), foi realizado em 150 cães atendidos pelo Serviço de Clínica Médica de Pequenos Animais da FMVZ - Unesp/Botucatu. Investigou-se a influência de fatores como presença do [...] proprietário, estado de saúde, diagnóstico de doença renal, raça, idade, sexo, decúbito, contenção, fluidoterapia, condição corpórea, temperamento, atividade física, dieta e atitude associados ou não à elevação da pressão arterial. Dos 150 cães, 34% encontravam-se sob a categoria de risco mínimo para o desenvolvimento de lesões hipertensivas, 14,6% com hipertensão branda, 22,6% com hipertensão moderada e 28,66%, com hipertensão grave. Houve influência, dos fatores analisados, na elevação da pressão arterial de acordo com a categoria de risco. Abstract in english The study of systolic, mean, diastolic and heart rate by the oscillometric indirect method (PetMapTM) was performed in 150 dogs attended by the Small Animal Service of Medicine of FMVZ - Unesp/Botucatu. The influence of factors such as presence of the owner, health status, diagnosis of kidney diseas [...] e, race, age, sex, recumbency, containment, fluid, body condition, temperament, physical activity, diet and attitude associated or not with elevated blood pressure was investigated. Of the 150 dogs, 34% were under the category of minimal risk for the development of hypertensive lesions, 14.6% with mild hypertension, 22.6% with moderate hypertension and 28.66% with severe hypertension. The analyzed factors influenced the elevation of blood pressure according to risk category.

M., Tebaldi; M.L.G., Lourenço; L.H.A., Machado; M.J., Sudano; L.R., Carvalho.

1456-14-01

287

Estudo da pressão arterial pelo método indireto oscilométrico (petmap® em cães domésticos não anestesiados Study of blood pressure by the indirect oscillometric method (petmap® in domestic unanesthetized dogs  

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Full Text Available O estudo das pressões arteriais sistólica, média, diastólica e da frequência cardíaca, pelo método indireto oscilométrico (petmap®, foi realizado em 150 cães atendidos pelo Serviço de Clínica Médica de Pequenos Animais da FMVZ - Unesp/Botucatu. Investigou-se a influência de fatores como presença do proprietário, estado de saúde, diagnóstico de doença renal, raça, idade, sexo, decúbito, contenção, fluidoterapia, condição corpórea, temperamento, atividade física, dieta e atitude associados ou não à elevação da pressão arterial. Dos 150 cães, 34% encontravam-se sob a categoria de risco mínimo para o desenvolvimento de lesões hipertensivas, 14,6% com hipertensão branda, 22,6% com hipertensão moderada e 28,66%, com hipertensão grave. Houve influência, dos fatores analisados, na elevação da pressão arterial de acordo com a categoria de risco.The study of systolic, mean, diastolic and heart rate by the oscillometric indirect method (PetMapTM was performed in 150 dogs attended by the Small Animal Service of Medicine of FMVZ - Unesp/Botucatu. The influence of factors such as presence of the owner, health status, diagnosis of kidney disease, race, age, sex, recumbency, containment, fluid, body condition, temperament, physical activity, diet and attitude associated or not with elevated blood pressure was investigated. Of the 150 dogs, 34% were under the category of minimal risk for the development of hypertensive lesions, 14.6% with mild hypertension, 22.6% with moderate hypertension and 28.66% with severe hypertension. The analyzed factors influenced the elevation of blood pressure according to risk category.

M. Tebaldi

2012-12-01

288

Estudo da pressão arterial pelo método indireto oscilométrico (petmap®) em cães domésticos não anestesiados / Study of blood pressure by the indirect oscillometric method (petmap®) in domestic unanesthetized dogs  

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Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese O estudo das pressões arteriais sistólica, média, diastólica e da frequência cardíaca, pelo método indireto oscilométrico (petmap®), foi realizado em 150 cães atendidos pelo Serviço de Clínica Médica de Pequenos Animais da FMVZ - Unesp/Botucatu. Investigou-se a influência de fatores como presença do [...] proprietário, estado de saúde, diagnóstico de doença renal, raça, idade, sexo, decúbito, contenção, fluidoterapia, condição corpórea, temperamento, atividade física, dieta e atitude associados ou não à elevação da pressão arterial. Dos 150 cães, 34% encontravam-se sob a categoria de risco mínimo para o desenvolvimento de lesões hipertensivas, 14,6% com hipertensão branda, 22,6% com hipertensão moderada e 28,66%, com hipertensão grave. Houve influência, dos fatores analisados, na elevação da pressão arterial de acordo com a categoria de risco. Abstract in english The study of systolic, mean, diastolic and heart rate by the oscillometric indirect method (PetMapTM) was performed in 150 dogs attended by the Small Animal Service of Medicine of FMVZ - Unesp/Botucatu. The influence of factors such as presence of the owner, health status, diagnosis of kidney diseas [...] e, race, age, sex, recumbency, containment, fluid, body condition, temperament, physical activity, diet and attitude associated or not with elevated blood pressure was investigated. Of the 150 dogs, 34% were under the category of minimal risk for the development of hypertensive lesions, 14.6% with mild hypertension, 22.6% with moderate hypertension and 28.66% with severe hypertension. The analyzed factors influenced the elevation of blood pressure according to risk category.

M., Tebaldi; M.L.G., Lourenço; L.H.A., Machado; M.J., Sudano; L.R., Carvalho.

289

Mecanismos fisiopatológicos del desbalance glomérulo-tubular en la hipertensión arterial Pathophysiological mechanisms of the lack of glomerulus-tubule balance in arterial high blood pressure  

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Full Text Available Las actuales tendencias e hipótesis para interpretar los mecanismos etiopatogénicos de la hipertensión arterial esencial, involucran al sistema renal como mecanismo preponderante en la regulación a largo plazo de la presión arterial y la existencia en él de algún fenómeno que puede conllevar a desbalance glomérulo-tubular, con preponderancia tubular Aunque el análisis de este último hecho no ha sido como tal abordado en la patogénesis del síndrome hipertensivo. Con el objetivo de interpretar el papel del desbalance glomérulo-tubular, con preponderancia tubular en la fisiopatología de la hipertensión arterial como fenómeno en el que confluyen múltiples mecanismos fisiopatológicos renales ya descritos, se revisaron estos últimos, de forma integrada y su relación causal con el desbalance glomérulo-tubular, con preponderancia tubular. La preponderancia tubular, punto común de los mecanismos que se discuten, favorece la disminución de la excreción fraccional de Na+, la retención hidrosalina y la elevación de la presión arterial.The current trends and hypotheses to know the etiopathogenesis mechanisms of the essential arterial high blood pressure involved the renal system as a prevailing mechanism in the long-term regulation of arterial pressure and the existence in it of some phenomenon that could lead to a glomerulus-tubule lack of balance with tubular preponderance. Although the analysis of this latter fact, has not been approached as such in pathogenesis of hypertensive syndrome. With the aim of to interpret the role of glomerulus-tubule lack of balance with tubular preponderance in pathophysiology of arterial high blood pressure as a phenomenon in which converging multiple renal pathophysiological mechanisms already described, these latter were reviewed in a integrated way and its causal relation with the above mentioned lack of balance with tubular preponderance. This preponderance, a common point of discussed mechanisms, favors the decrease of a fractional releasing of Na+, the hydrosaline retention and the raise of arterial pressure.

María Ofelia Barber Fox

2010-12-01

290

Mecanismos fisiopatológicos del desbalance glomérulo-tubular en la hipertensión arterial / Pathophysiological mechanisms of the lack of glomerulus-tubule balance in arterial high blood pressure  

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Full Text Available SciELO Cuba | Language: Spanish Abstract in spanish Las actuales tendencias e hipótesis para interpretar los mecanismos etiopatogénicos de la hipertensión arterial esencial, involucran al sistema renal como mecanismo preponderante en la regulación a largo plazo de la presión arterial y la existencia en él de algún fenómeno que puede conllevar a desba [...] lance glomérulo-tubular, con preponderancia tubular Aunque el análisis de este último hecho no ha sido como tal abordado en la patogénesis del síndrome hipertensivo. Con el objetivo de interpretar el papel del desbalance glomérulo-tubular, con preponderancia tubular en la fisiopatología de la hipertensión arterial como fenómeno en el que confluyen múltiples mecanismos fisiopatológicos renales ya descritos, se revisaron estos últimos, de forma integrada y su relación causal con el desbalance glomérulo-tubular, con preponderancia tubular. La preponderancia tubular, punto común de los mecanismos que se discuten, favorece la disminución de la excreción fraccional de Na+, la retención hidrosalina y la elevación de la presión arterial. Abstract in english The current trends and hypotheses to know the etiopathogenesis mechanisms of the essential arterial high blood pressure involved the renal system as a prevailing mechanism in the long-term regulation of arterial pressure and the existence in it of some phenomenon that could lead to a glomerulus-tubu [...] le lack of balance with tubular preponderance. Although the analysis of this latter fact, has not been approached as such in pathogenesis of hypertensive syndrome. With the aim of to interpret the role of glomerulus-tubule lack of balance with tubular preponderance in pathophysiology of arterial high blood pressure as a phenomenon in which converging multiple renal pathophysiological mechanisms already described, these latter were reviewed in a integrated way and its causal relation with the above mentioned lack of balance with tubular preponderance. This preponderance, a common point of discussed mechanisms, favors the decrease of a fractional releasing of Na+, the hydrosaline retention and the raise of arterial pressure.

María Ofelia, Barber Fox; Katiana, Galvizu Díaz; Aydelín, Pérez Ramos; María Ofelia, Fox Pascual.

291

Eprosartan-based hypertension therapy, systolic arterial blood pressure and cognitive function: analysis of Middle East data from the OSCAR study  

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Full Text Available Ghazi Ahmad Radaideh1, Patrick Choueiry2, Amr Ismail2, Elie Eid3, Jean-Pascal Berrou4, Armand Sedefdjian5, Frank Sévenier6, Atul Pathak71Rashid Hospital of Dubai, Dubai, United Arab Emirates; 2Abbott Gulf – Levant; 3Division of Cardiology, American University of Beirut, Beirut, Lebanon; 4Abbott Products Operations AG, Allschwill, Switzerland; 5EvidenceBased Communication (EBC, Rueil-Malmaison, France; 6Fovéa Group, Rueil-Malmaison, France; 7Departments of Clinical Pharmacology and Cardiology, Institut National de la Santé et de la Recherche Médicale U1048, Université de Toulouse-UPS, Centre Hospitalier Universitaire de Toulouse, Toulouse, FranceBackground: Studies have indicated a relationship between hypertension and cognitive function. The possible effect of antihypertensive therapy on cognitive disorders is therefore a matter of interest.Materials and methods: The Observational Study on Cognitive function And SBP Reduction (OSCAR was an open-label, multinational trial designed to evaluate the impact of eprosartan-based antihypertensive therapy on cognitive function in patients with essential hypertension. Eprosartan 600 mg/day for 6 months (with provision for additional medication as needed was initiated in hypertensive subjects aged ?50 years. A total of 853 patients in an intention-to-treat cohort from seven countries of the Middle East was identified for subgroup analysis.Results: Arterial blood pressure was reduced significantly (P < 0.001 during the study: At the end of 6 months of eprosartan-based therapy, the mean (±SD reduction from baseline was 32.1 ± 14.3/14.6.3 ± 8.6 mmHg (P < 0.001. Mean pulse pressure was reduced by 18.3 ± 13.1 mmHg (P < 0.0001 vs baseline. Blood pressure was normalized (systolic <140 mmHg and diastolic <90 mmHg in 68.2% of patients. The overall mean Mini-Mental State Examination (MMSE score after 6 months of eprosartan-based therapy was one-point higher than at baseline (P < 0.001. MMSE score on completion of 6 months’ follow-up was either unchanged or increased from baseline in 793 (93% individuals and decreased in 60 (7%. Factors associated with stability of or improvement in cognitive function included MMSE score at baseline, diastolic blood pressure (DBP at baseline, and treatment-induced change in DBP.Conclusion: Results from the Middle East subgroup of OSCAR are supportive of the hypothesis that antihypertensive therapy based on angiotensin-receptor blocker therapy with eprosartan may be associated with preservation or improvement of cognitive function.Keywords: hypertension, eprosartan, cognitive function, Middle East 

Radaideh G

2011-08-01

292

Association Between Atherosclerosis in Carotid Artery and Elastic Modulus of Brachial Artery  

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Full Text Available Background: Common carotid arterial stiffness can be assessed during carotid arterial ultrasonography, but its association with brachial stiffness, a well-defined cardiovascular risk factor, has not been clarified. The aim of this study was to examine the relationship between common carotid artery and brachial artery stiffness. Methods: The static pressure-strain elastic modulus of the common carotid and brachial arteries were evaluated in 40 men with 15 healthy carotids, 15 mild carotid stenoses, and 10 severe carotid stenoses, by B-mode and Doppler ultrasonography. The local elastic modulus was estimated by the measurement of the arterial strain; the static pressure was also measured based on the peak-systolic and end-diastolic velocity in each artery.Results: The elastic modulus of the right common carotid artery (RCCA and right brachial artery (RBA increased linearly with the growth of atherosclerosis from 1772±566 Pa and 2639±1096 Pa for the normal subjects to 6168±1026 Pa and 5587±1592 Pa for the severe stenosis group, respectively. In the three groups; healthy, mild stenosis, and severe stenosis; there was a significant difference in the elastic modulus of the right common carotid artery between the groups and also for the right brachial artery, separately (p-value<0.05. The Pearson correlation analysis showed a significant correlation between the elastic modulus of the right common carotid artery and the elastic modulus of the right brachial artery.Conclusion: The brachial artery elastic modulus is associated with the common carotid elastic modulus. This study showed that atherosclerosis was a generalized process that might involve the entire vasculature. An evaluation of the elastic modulus of the RBA, however, showed that there were fundamental differences in the dynamic behavior of the brachial artery when compared to elastic arteries, such as the common carotid artery.

Manijhe Mokhtari-Dizaji

2007-06-01

293

Influence of anxiety on blood pressure and heart rate during dental treatment / Influência da ansiedade na pressão arterial e frequência cardíaca durante o tratamento odontológico  

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Full Text Available SciELO Brazil | Language: English Abstract in portuguese OBJETIVO: Avaliar a influência da ansiedade detectadas por meio de uma escala de ansiedade sobre os níveis de pressão arterial e a frequência cardíaca, durante o atendimento odontológico de pacientes das Clínicas de Odontologia do Centro Universitário de São José do Rio Preto, São Paulo, Brasil. MET [...] ODOLOGIA: Foram selecionados ao acaso 60 voluntários que receberam atendimento odontológico de urgência. Foi utilizada uma escala para avaliar o grau de ansiedade dos voluntários. Foi verificada também a pressão arterial e a frequência cardíaca dos pacientes em três períodos distintos: pré, trans e pós-anestesia odontológica. RESULTADOS: A ansiedade não foi afetada pelas faixas etárias, apenas pelo gênero. A ansiedade não deve ser uma barreira, entre profissional/paciente e, ainda, a ansiedade apresentada não é um sinal clínico levado em consideração para a aplicação de medidas de controle. CONCLUSÃO: Não houve alteração da pressão arterial sistólica, diastólica e da frequência cardíaca em relação ao grau de ansiedade e dor e ao tipo de solução anestésica empregada. Abstract in english PURPOSE: To evaluate the influence of anxiety on blood pressure and heart rate during dental care in patients of the Dentistry Clinic in Rio Preto University Center - UNIRP, São José do Rio Preto, São Paulo, Brazil. METHODS: A sample of 60 volunteers who sought for the dental screening service was s [...] elected. We used a scale to evaluate the volunteers' anxiety level. Blood pressure and heart rate of patients were also checked in different periods of the dental treatment. RESULTS: Most of the volunteers were women. The relation between anxiety and pain before treatment, revealed that 54 (90.0%) had no pain. The patients had low anxiety towards the use of different anesthetic solutions used during dental procedures. There was no statistically significant difference concerning to systolic blood pressure at first and, after application of anesthetic, given the degree of anxiety. Heart rate does not change as a function of anxiety. There is a slight change in heart rate after anesthesia, and it soon gets back to normal. CONCLUSION: There was no difference in behavior of systolic and diastolic blood pressure in relation to the anxiety level and pain, measured before, during and after the procedure. Heart rate did not change during dental treatment in the patient anxiety level.

Jean Carlos Fernandes, Goulart; Matheus Dias, Pinheiro; Rodrigo Ventura, Rodrigues; Fabiano de Sant' Ana dos, Santos; Alex Tadeu, Martins; Fábio Luiz Ferreira, Scannavino.

294

Correlation between systemic blood pressure measured by oscillometry and age and serum sodium level in healthy dogsCorrelação entre a pressão arterial sistêmica aferida por método oscilométrico com a idade e o nível sérico de sódio em cães hígidos  

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Full Text Available Blood pressure has received attention in current veterinary clinic and can be measured in a non-invasive way by the oscillometric method, among others. Factors such as age have already been related to disorders on blood pressure. Sodium, vital element in cell physiology of animals, has been reported to increase blood pressure. Thus, this work correlates age, the values of blood pressure, both systolic and diastolic, with the serum levels of sodium in healthy adult dogs. We studied 23 adult healthy dogs of both sexes and varying age fed with commercial feed (standard. The arterial pressure, systolic (SBP and diastolic (DBP, and pulse were measured by digital human sphygmomanometer. The level of serum sodium was obtained by the method of enzyme reagent in kinetic mode, using a commercial kit. We performed Pearson correlation between variables. The values of SBP, DBP, pulse and serum sodium varied respectively from 96 – 184mmHg, 53 – 137mmHg, 64 – 135bpm and 120-157mEq/L. We observed a positive correlation between the variables age and SBP, age and DBP, SBP and sodium, and sodium and DBP, while the values of serum sodium and age showed a negative correlation. Regarding this study conditions, we conclude that there is little interference in the values of blood pressure, both systolic and diastolic, regarding age and serum sodium in healthy adult dogs. A pressão arterial vem recebendo destaque na clínica veterinária atual, podendo ser mensurada de forma não-invasiva, pelo método oscilométrico, entre outros. Fatores como a idade já foram relacionados com distúrbios na pressão arterial. O sódio, elemento vital na fisiologia celular de animais, já foi relacionado com o aumento da pressão arterial. Desta forma, este trabalho correlaciona a idade, os valores da pressão arterial sistêmica, sistólica e diastólica, com os níveis séricos de sódio em cães adultos hígidos. Foram estudados 23 cães adultos, hígidos, de ambos os sexos e idade variável, alimentados com ração comercial (standard. As pressões arteriais, sistólica (PAS e diastólica (PAD, e pulso foram aferidas por esfigmomanômetro digital humano. O nível sérico de sódio foi obtido pelo método de reagente enzimático em modo cinético, utilizando kit comercial. Foi realizada a Correlação de Pearson entre as variáveis. Os valores da PAS, PAD, pulso e sódio sérico, variaram respectivamente de 96 – 184mmHg, 53- 137mmHg, 64 – 135bpm e 120 –157mEq/L. Foi observada uma correlação positiva entre as variáveis idade e PAS, idade e PAD, sódio e PAS, e sódio e PAD, enquanto os valores de idade e sódio sérico, demonstraram uma correlação negativa. Nas condições deste estudo conclui-se que há pouca interferência nos valores de pressão arterial, sistólica e diastólica, pela idade e o nível sérico de sódio, em cães adultos hígidos.

Eduardo Garcia Fontoura

2013-06-01

295

Exercício físico controla pressão arterial e melhora qualidade de vida / Exercise control blood pressure and improvement quality of life  

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Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese INTRODUÇÃO: Para o tratamento correto da hipertensão arterial, é plausível a hipótese de que diante da prática regular de exercícios físicos estes pacientes não necessitariam de fármacos anti-hipertensivos. OBJETIVO: Avaliar o efeito do tratamento exclusivo com exercício físico na pressão arterial ( [...] PA) e qualidade de vida (QV) de hipertensos. MÉTODO: Ensaio clínico com 32 hipertensos sedentários, 55±9 anos, que estavam sob tratamento farmacológico (TF) aleatoriamente alocados em Grupo Exercício (GE) e Grupo Controle (GC). No GE, 18 indivíduos (50% mulheres) após pelo menos dez dias de interrupção do TF iniciaram programa de exercício de dez semanas, 3x/semana, 30 minutos de exercício aeróbio seguidos por exercícios resistidos, enquanto 14 do GC (57% mulheres) se mantiveram sob TF. Foi verificada PA sistólica (PAS) e diastólica (PAD) no início e final do estudo pelo método auscultatório clássico e QV pelo questionário MINICHAL. Os dados foram expressos por M±DP, usou-se teste t de Student, U de Mann-Whitney e Wilcoxon, considerando-se p Abstract in english BACKGROUND: Hypertension can be correctly treated when exercise is regularly practiced and hence, patients would not need anti-hypertensive drugs. PURPOSE: To evaluate the effect of treatment exclusively with exercise on blood pressure (BP) and quality of life (QL) of hypertensive subjects. METHODS: [...] Clinical trial with 32 sedentary hypertensive subjects, aged 55 ± 9 years, under pharmacological treatment (PT) randomly allocated to Exercise Group (EG) and Control Group (CG). At EG, 18 subjects (50% women) at least 10 days after the cessation of PT started the exercise program of 10 weeks, 3x/week, 30 minutes of aerobic exercise followed by resistance exercises, while 14 CG (57% women) remained under PT. Systolic blood pressure (SBP) and diastolic blood pressure (DBP) was evaluated by auscultation at the beginning and end and QL was evaluated using the questionnaire MINICHAL. Data were expressed as mean ± SD and statistical analysis was performed using t test, Mann Whitney U and Wilcoxon tests. RESULTS: At the beginning and end of the study, no significant differences in were observed in BP between groups. Within groups, BP in EG remained similar to the values before drugs were removed (SBP 132.2 ± 13.3 x 134.4 ± 10 mmHg, DBP 85.0 ± 9 x 85.3 ± 10 mmHg p = ns) and the CG (SBP 127.2 ± 19 x 130.2 ± 16 mmHg, DBP 82.1 ± 16 x 85.3 ± 12 mmHg p = ns).For QL, no inter-group difference was observed in scores at the beginning and end; intra-group significant improvement in the emotional aspect of the EG (p = 0.02). CONCLUSION: The anti-hypertensive therapy with exercise only in comparison to conventional pharmacological treatment allowed the same BP control and better QL perception.

Daiana Cristine, Bündchen; Isabel de Castro, Schenkel; Rafaella Zulianello dos, Santos; Tales de, Carvalho.

2013-04-01

296

Exercício físico controla pressão arterial e melhora qualidade de vida / Exercise control blood pressure and improvement quality of life  

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Full Text Available SciELO Brazil | Language: Portuguese Abstract in portuguese INTRODUÇÃO: Para o tratamento correto da hipertensão arterial, é plausível a hipótese de que diante da prática regular de exercícios físicos estes pacientes não necessitariam de fármacos anti-hipertensivos. OBJETIVO: Avaliar o efeito do tratamento exclusivo com exercício físico na pressão arterial ( [...] PA) e qualidade de vida (QV) de hipertensos. MÉTODO: Ensaio clínico com 32 hipertensos sedentários, 55±9 anos, que estavam sob tratamento farmacológico (TF) aleatoriamente alocados em Grupo Exercício (GE) e Grupo Controle (GC). No GE, 18 indivíduos (50% mulheres) após pelo menos dez dias de interrupção do TF iniciaram programa de exercício de dez semanas, 3x/semana, 30 minutos de exercício aeróbio seguidos por exercícios resistidos, enquanto 14 do GC (57% mulheres) se mantiveram sob TF. Foi verificada PA sistólica (PAS) e diastólica (PAD) no início e final do estudo pelo método auscultatório clássico e QV pelo questionário MINICHAL. Os dados foram expressos por M±DP, usou-se teste t de Student, U de Mann-Whitney e Wilcoxon, considerando-se p Abstract in english BACKGROUND: Hypertension can be correctly treated when exercise is regularly practiced and hence, patients would not need anti-hypertensive drugs. PURPOSE: To evaluate the effect of treatment exclusively with exercise on blood pressure (BP) and quality of life (QL) of hypertensive subjects. METHODS: [...] Clinical trial with 32 sedentary hypertensive subjects, aged 55 ± 9 years, under pharmacological treatment (PT) randomly allocated to Exercise Group (EG) and Control Group (CG). At EG, 18 subjects (50% women) at least 10 days after the cessation of PT started the exercise program of 10 weeks, 3x/week, 30 minutes of aerobic exercise followed by resistance exercises, while 14 CG (57% women) remained under PT. Systolic blood pressure (SBP) and diastolic blood pressure (DBP) was evaluated by auscultation at the beginning and end and QL was evaluated using the questionnaire MINICHAL. Data were expressed as mean ± SD and statistical analysis was performed using t test, Mann Whitney U and Wilcoxon tests. RESULTS: At the beginning and end of the study, no significant differences in were observed in BP between groups. Within groups, BP in EG remained similar to the values before drugs were removed (SBP 132.2 ± 13.3 x 134.4 ± 10 mmHg, DBP 85.0 ± 9 x 85.3 ± 10 mmHg p = ns) and the CG (SBP 127.2 ± 19 x 130.2 ± 16 mmHg, DBP 82.1 ± 16 x 85.3 ± 12 mmHg p = ns).For QL, no inter-group difference was observed in scores at the beginning and end; intra-group significant improvement in the emotional aspect of the EG (p = 0.02). CONCLUSION: The anti-hypertensive therapy with exercise only in comparison to conventional pharmacological treatment allowed the same BP control and better QL perception.

Daiana Cristine, Bündchen; Isabel de Castro, Schenkel; Rafaella Zulianello dos, Santos; Tales de, Carvalho.

297

Exercício físico controla pressão arterial e melhora qualidade de vida Exercise control blood pressure and improvement quality of life  

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Full Text Available INTRODUÇÃO: Para o tratamento correto da hipertensão arterial, é plausível a hipótese de que diante da prática regular de exercícios físicos estes pacientes não necessitariam de fármacos anti-hipertensivos. OBJETIVO: Avaliar o efeito do tratamento exclusivo com exercício físico na pressão arterial (PA e qualidade de vida (QV de hipertensos. MÉTODO: Ensaio clínico com 32 hipertensos sedentários, 55±9 anos, que estavam sob tratamento farmacológico (TF aleatoriamente alocados em Grupo Exercício (GE e Grupo Controle (GC. No GE, 18 indivíduos (50% mulheres após pelo menos dez dias de interrupção do TF iniciaram programa de exercício de dez semanas, 3x/semana, 30 minutos de exercício aeróbio seguidos por exercícios resistidos, enquanto 14 do GC (57% mulheres se mantiveram sob TF. Foi verificada PA sistólica (PAS e diastólica (PAD no início e final do estudo pelo método auscultatório clássico e QV pelo questionário MINICHAL. Os dados foram expressos por M±DP, usou-se teste t de Student, U de Mann-Whitney e Wilcoxon, considerando-se p BACKGROUND: Hypertension can be correctly treated when exercise is regularly practiced and hence, patients would not need anti-hypertensive drugs. PURPOSE: To evaluate the effect of treatment exclusively with exercise on blood pressure (BP and quality of life (QL of hypertensive subjects. METHODS: Clinical trial with 32 sedentary hypertensive subjects, aged 55 ± 9 years, under pharmacological treatment (PT randomly allocated to Exercise Group (EG and Control Group (CG. At EG, 18 subjects (50% women at least 10 days after the cessation of PT started the exercise program of 10 weeks, 3x/week, 30 minutes of aerobic exercise followed by resistance exercises, while 14 CG (57