A new non-metallic anchorage system for post-tensioning applications using CFRP tendons

Science.gov (United States)

Taha, Mahmoud Reda

The objective of the work described in this thesis is to design, develop and test a new non-metallic anchorage system for post-tensioning applications using CFRP tendons. The use of a non-metallic anchorage system should eliminate corrosion and deterioration concerns in the anchorage zone. The development of a reliable non-metallic anchorage would provide an important contribution to this field of knowledge. The idea of the new anchorage is to hold the tendon through mechanical gripping. The anchorage consists of a barrel with a conical housing and four wedges. The anchorage components are made of ultra high performance concrete (UHPC) specially developed for the anchorage. Sixteen concrete mixtures with different casting and curing regimes were examined to develop four UHPC mixtures with compressive strengths in excess of 200 MPa. The UHPC mixtures showed very dense microstructures with some unique characteristics. To enhance the fracture toughness of the newly developed UHPC, analytical and experimental analyses were performed. Using 3 mm chopped carbon fibres, a significant increase in the fracture toughness of UHPC was achieved. The non-metallic anchorage was developed with the UHPC with enhanced fracture toughness. The barrel required careful wrapping with CFRP sheets to provide the confinement required to utilize the strength and toughness of the UHPC. Thirty-three anchorages were tested under both static and dynamic loading conditions. The non-metallic anchorage showed excellent mechanical performance and fulfilled the different requirements of a post-tensioning anchorage system. The development of the new non-metallic anchorage will widen the inclusion of CFRP tendons in post-tensioned concrete/masonry structures. The new system will offer the opportunity to exploit CFRP tendons effectively creating an innovative generation of corrosion-free, smart structures.

Finite element simulation and testing of ISW CFRP anchorage

DEFF Research Database (Denmark)

Schmidt, Jacob Wittrup; Goltermann, Per; Hertz, Kristian Dahl

2013-01-01

is modelled in the 3D finite Element program ABAQUS, just as digital image correlation (DIC) testing was performed to verify the finite element simulation. Also a new optimized design was produced to ensure that the finite element simulation and anchorage behaviour correlated well. It is seen....... This paper presents a novel mechanical integrated sleeve wedge anchorage which seem very promising when perusing the scope of ultimate utilization of CFRP 8mm rods (with a tension capacity of approximately 140kN). Compression transverse to the CFRP is evaluated to prevent premature failure. The anchorage...

Comparison of anchorage reinforcement with temporary anchorage devices or a Herbst appliance during lingual orthodontic protraction of mandibular molars without maxillary counterbalance extraction.

Science.gov (United States)

Metzner, Rebecca; Schwestka-Polly, Rainer; Helms, Hans-Joachim; Wiechmann, Dirk

2015-06-20

Orthodontic protraction of mandibular molars without maxillary counterbalance extraction in cases of aplasia or extraction requires stable anchorage. Reinforcement may be achieved by using either temporary anchorage devices (TAD) or a fixed, functional appliance. The objective was to compare the clinical effectiveness of both methods by testing the null-hypothesis of no significant difference in velocity of space closure (in mm/month) between them. In addition, we set out to describe the quality of posterior space management and treatment-related factors, such as loss of anchorage (assessed in terms of proportions of gap closure by posterior protraction or anterior retraction), frequencies of incomplete space closure, and potential improvement in the sagittal canine relationship. Twenty-seven subjects (15 male/12 female) with a total of 36 sites treated with a lingual multi-bracket appliance were available for retrospective evaluation of the effects of anchorage reinforcement achieved with either a Herbst appliance (n(subjects) = 15; 7 both-sided/8 single-sided Herbst appliances; n(sites) = 22) or TADs (n(subjects )= 12; 2 both-sided; 10 single-sided; n(sites) = 14). Descriptive analysis was based on measurements using intra-oral photographs which were individually scaled to corresponding plaster casts and taken on insertion of anchorage mechanics (T1), following removal of anchorage mechanics (T2), and at the end of multi-bracket treatment (T3). The null-hypothesis was rejected: The rate of mean molar protraction was significantly faster in the Herbst-reinforced group (0.51 mm/month) than in the TAD group (0.35). While complete space closure by sheer protraction of posterior teeth was achieved in all Herbst-treated cases, space closure in the TAD group was achieved in 76.9% of subjects by sheer protraction of molars, and it was incomplete in 50% of cases (mean gap residues: 1 mm). Whilst there was a deterioration in the canine relationship towards

Seismic verification of nuclear plant equipment anchorage

International Nuclear Information System (INIS)

Lepiece, M.; Van Vyve, J.

1991-01-01

More than 60% of the electrical power of Belgium is generated by seven PWR nuclear power plants. For three of them, the electro-mechanical equipment had to be reassessed after ten years of operation, because the seismic requirements were upgraded from 0.1 g to 0.17 g free field ground acceleration. The seismic requalification of the active equipment was a critical problem as the classical methods were too conservative. The approach based on the use of the past experience on the seismic behavior of nonnuclear equipment, chosen and developed by the SQUG, had to be transposed to the Belgian N.P.P. The decision of the accept-ability of equipment relies heavily on the aseismatic capacity of anchorage. The Electrical Power Research Institute (EPRI) developed the procedure and guideline for the demonstration of the aseismatic adequacy of equipment anchorage in a cost-effective and consistent manner, to support the decision by Seismic Review Team. The field inspection procedure to identify the type of fasteners and detect their possible defects and the verification procedure developed to calculate the aseismatic capacity of equipment anchorage on the strength of fasteners, the aseismatic capacity of anchorage and the comparison of the capacity with the demand are reported. (K.I.)

Research on the Bond Anchorage Properties of Alkali-Activated Slag Cementitious Material

Science.gov (United States)

Zhu, J.; Zheng, W. Z.; Leng, Y. F.; Qin, C. Z.; Xu, Z. Z.

2017-12-01

By bond-anchorage property tests at 20°C ∼500°C, the distribution of shear stress between carbon fiber sheets and concrete at all levels of loading and anchorage lengths were measured, which means the bond lengths during CFRP sheets are pulled off at the same time when the concrete is torn and stripped were gotten. The failure modes were obtained. In addition, the failure loads were measured, and the calculated formulas of anchorage lengths were identified by fitting at high temperature. It can be seen that the anchorage lengths of carbon fiber sheets increase with increasing temperature at 20°C ∼100°C, the anchorage lengths of carbon fiber sheets decrease with increasing temperature at 100°C ∼500°C. Tests prove that AASCM has favorable high-temperature resistant and bond anchorage properties.

Procedures adopted by orthodontists for space closure and anchorage control

OpenAIRE

Monini,André da Costa; Gandini Júnior,Luiz Gonzaga; Santos-Pinto,Ary dos; Maia,Luiz Guilherme Martins; Rodrigues,Willian Caetano

2013-01-01

OBJECTIVE: The aim of this study was to identify the procedures adopted by Brazilian orthodontists in the following situations: extraction space closure, anchorage control in case of necessary anchorage for group A and frequency of skeletal anchorage use, especially in the upper jaw. METHOD: A questionnaire was sent to the e-mail address of all dentists registered in the Brazilian Federal Council of Dentistry. RESULTS: The results showed that most Brazilian orthodontists usually perform extra...

Mini-Implants in the Anchorage Armamentarium: New Paradigms in the Orthodontics

Directory of Open Access Journals (Sweden)

Masaru Yamaguchi

2012-01-01

Full Text Available Paradigms have started to shift in the orthodontic world since the introduction of mini-implants in the anchorage armamentarium. Various forms of skeletal anchorage, including miniscrews and miniplates, have been reported in the literature. Recently, great emphasis has been placed on the miniscrew type of temporary anchorage device (TAD. These devices are small, are implanted with a relatively simple surgical procedure, and increase the potential for better orthodontic results. Therefore, miniscrews not only free orthodontists from anchorage-demanding cases, but they also enable clinicians to have good control over tooth movement in 3 dimensions. The miniplate type also produces significant improvements in treatment outcomes and has widened the spectrum of orthodontics. The purpose of this paper is to update clinicians on the current concepts and versatile uses and clinical applications of skeletal anchorage in orthodontics.

77 FR 43514 - Anchorage Regulations; Narragansett Bay and Rhode Island Sound, RI

Science.gov (United States)

2012-07-25

...-AA01 Anchorage Regulations; Narragansett Bay and Rhode Island Sound, RI AGENCY: Coast Guard, DHS... Narragansett Bay, Rhode Island, and adding an offshore anchorage in Rhode Island Sound south of Brenton Point... rulemaking (NPRM) entitled ``Anchorage Regulations; Narragansett Bay and Rhode Island Sound, RI,'' in the...

[Clinical effects of micro-implant and traditional anchorage in orthodontic treatments].

Science.gov (United States)

Qian, Yi; Zhou, Hua-Jie; Wu, Jian-Hua

2017-06-01

To analyze the value of micro-implant and traditional anchorage in the treatment of malocclusion. From Jan 2015 to Jan 2016, 20 cases with malocclusion were randomly divided into control group(10) and experimental group (10). A comparison was conducted between the control group, in which traditional anchorage was used and the experimental group, in which micro-implant anchorage was adopted. The data were analyzed with SPSS 17.0 software package. There was significant difference of U1-NA, L1-NB, U1-APg, U6-PtPNS between the 2 groups(PMicro-implant anchorage can improve overjet relation of the anterior teeth and effect of orthodontic treatment.

Factors predisposing to maxillary anchorage loss: a retrospective study of 1403 cases.

Directory of Open Access Journals (Sweden)

Hong Su

Full Text Available Anchorage loss is very disturbing for orthodontists and patients during orthodontic treatment, which usually results in bad treatment effects. Despite the same treatment strategy, different patients show different tendencies toward anchorage loss, which influences the treatment results and should preferably be predicted before the treatment is begun. However, relatively little research has been conducted on which patients are more likely to lose anchorage. The mesial tipping of the first molar marks the onset of anchorage loss, and changes in the angulation of the first molar are closely related to anchorage loss. This cross-sectional study aimed to determine how the mesiodistal angulation of the upper first molars changes during general orthodontic treatment and to identify the individual physiologic factors leading to these changes in a large sample of 1403 patients with malocclusion. The data indicate that the upper first molars tend to be tipped mesially during orthodontic treatment, and this constitutes a type of anchorage loss that orthodontists should consider carefully. Compared to treatment-related factors, patients' physiologic characteristics have a greater influence on changes in the angulation of the upper first molars during orthodontic treatment. The more distally tipped the upper first molars are before treatment, the more they will tip mesially during treatment. Mesial tipping of the upper first molars, and therefore, anchorage loss, is more likely to occur in adolescents, males, patients with class II malocclusion and patients who have undergone maxillary premolar extraction. This finding is of clinical significance to orthodontists who wish to prevent iatrogenic anchorage loss by tipping originally distally tipped upper molars forward, and provides a new perspective on anchorage during orthodontic treatment planning.

Research on Anchorage Performance of Grouting Anchor Connection of Precast Concrete Structure

Science.gov (United States)

Wang, Donghui; Liu, Xudong; Wang, Sheng; Cao, Xixi

2018-03-01

The bonding of grouted anchor bars is one of the vertical connection forms of steel bars in fabricated concrete structures. The performance of grouted connection is mainly affected by the anchorage length and lap length of steel bars. The mechanisms of bond and anchorage between steel bar and concrete are analyzed, and the factors that influence the anchorage performance of steel bar are systematically summarized. Results show that the bond and anchorage performance of steel and concrete have been studied widely, but there are still shortcomings, and the connection forms need to be further improved.

Application and Curative Effect of Micro-implant Anchorage in ...

African Journals Online (AJOL)

research hot spot in the Department of. Stomatology. Instead of taking teeth as the basis, as was previously the case, this new anchorage exerts the counteracting force of orthodontics on the jaw, thus completely avoiding the displacement of teeth. It solves a lot of problems existing in clinical anchorage. Micro - implant.

Flexural Strengthening of RC Slabs with Prestressed CFRP Strips Using Different Anchorage Systems

Directory of Open Access Journals (Sweden)

José Sena-Cruz

2015-10-01

Full Text Available Externally Bonded Reinforcement (EBR technique has been widely used for flexural strengthening of concrete structures by using carbon fiber-reinforced polymers (CFRP. EBR technique offers several structural advantages when the CFRP material is prestressed. This paper presents an experimental and numerical study on reinforced (RC slabs strengthened in flexure with prestressed CFRP strips as a structural strengthening system. The strips are applied as an externally bonded reinforcement (EBR and anchored with either a mechanical or a gradient anchorage. The former foresees metallic anchorage plates fixed to the concrete substrate, while the latter is based on an accelerated epoxy resin curing followed by a segment-wise prestress force decrease at the strip ends. Both anchorage systems, in combination with different CFRP strip geometries, were subjected to static loading tests. It could be demonstrated that the composite strip’s performance is better exploited when prestressing is used, with slightly higher overall load carrying capacities for mechanical anchorages than for the gradient anchorage. The performed investigations by means of a cross-section analysis supported the experimental observation that in case a mechanical anchorage is used, progressive strip debonding changes the fully bonded configuration to an unbonded end-anchored system. The inclusion of defined debonding criteria for both the anchorage zones and free length between the anchorage regions allowed to precisely capture the ultimate loading forces.

77 FR 60081 - Anchorages; Captain of the Port Puget Sound Zone, WA

Science.gov (United States)

2012-10-02

...'31'' W. Thorndike Bay Emergency Explosives Anchorage. Coordinates would be revised to read: All... 048[deg]T to point of origin. (6) Thorndike Bay Emergency Explosives Anchorage. All waters in a...

78 FR 59914 - Foreign-Trade Zone 160-Anchorage, Alaska; Application for Reorganization Under Alternative Site...

Science.gov (United States)

2013-09-30

...: Site 1 (56.89 acres)--the Port of Anchorage and Port of Anchorage Industrial Park, 1075 Dock Rd., 1076... acres)--619 East Ship Creek Ave., Anchorage; Site 6 (12.2 acres)-- Douglas Management Company, 660...

Anchorage Behaviors of Frictional Tieback Anchors in Silty Sand

Science.gov (United States)

Hsu, Shih-Tsung; Hsiao, Wen-Ta; Chen, Ke-Ting; Hu, Wen-Chi; Wu, Ssu-Yi

2017-06-01

Soil anchors are extensively used in geotechnical applications, most commonly serve as tieback walls in deep excavations. To investigate the anchorage mechanisms of this tieback anchor, a constitutive model that considers both strain hardening and softening and volume dilatancy entitled SHASOVOD model, and FLAC3D software are used to perform 3-D numerical analyses. The results from field anchor tests are compared with those calculated by numerical analyses to enhance the applicability of the numerical method. After the calibration, this research carried out the parameter studies by numerical analyses. The numerical results reveal that whether the yield of soil around an anchor develops to ground surface and/or touches the diaphragm wall depending on the overburden depth H and the embedded depth Z of an anchor, this study suggests the minimum overburden and embedded depths to avoid the yield of soils develop to ground surface and/or touch the diaphragm wall. When the embedded depth, overburden depth or fixed length of an anchor increases, the anchorage capacity also increases. Increasing fixed length should be the optimum method to increase the anchorage capacity for fixed length less than 20m. However, when the fixed length of an anchor exceeds 30 m, the increasing rate of anchorage capacity per fixed length decreases, and progressive yield occurs obviously between the fixed length and surrounding soil.

76 FR 59596 - Anchorage Regulations; Newport, RI

Science.gov (United States)

2011-09-27

... up to three cruise ships simultaneously in anchorage ``D''. For the convenience and safety of... standards (e.g., specifications of materials, performance, design, or operation; test methods; sampling...

77 FR 6010 - Anchorage Regulations; Newport, RI

Science.gov (United States)

2012-02-07

... anchor up to three cruise ships simultaneously in anchorage ``D''. For the convenience and safety of..., design, or operation; test methods; sampling procedures; and related management systems practices) that...

Inspection Mechanism and Experimental Study of Prestressed Reverse Tension Method under PC Beam Bridge Anchorage

Science.gov (United States)

Peng, Zhang

2018-03-01

the prestress under anchorage is directly related to the structural security and performance of PC beam bridge. The reverse tension method is a kind of inspection which confirms the prestress by exerting reversed tension load on the exposed prestressing tendon of beam bridge anchoring system. The thesis elaborately expounds the inspection mechanism and mechanical effect of reverse tension method, theoretically analyzes the influential elements of inspection like tool anchorage deformation, compression of conjuncture, device glide, friction of anchorage loop mouth and elastic compression of concrete, and then presents the following formula to calculate prestress under anchorage. On the basis of model experiment, the thesis systematically studies some key issues during the reverse tension process of PC beam bridge anchorage system like the formation of stress-elongation curve, influential factors, judgment method of prestress under anchorage, variation trend and compensation scale, verifies the accuracy of mechanism analysis and demonstrates: the prestress under anchorage is less than or equal to 75% of the ultimate strength of prestressing tendon, the error of inspect result is less than 1%, which can meet with the demands of construction. The research result has provided theoretical basis and technical foundation for the promotion and application of reverse tension in bridge construction.

Quantification of temperature effect on impedance monitoring via PZT interface for prestressed tendon anchorage

Science.gov (United States)

Huynh, Thanh-Canh; Kim, Jeong-Tae

2017-12-01

In this study, the quantification of temperature effect on impedance monitoring via a PZT interface for prestressed tendon-anchorage is presented. Firstly, a PZT interface-based impedance monitoring technique is selected to monitor impedance signatures by predetermining sensitive frequency bands. An analytical model is designed to represent coupled dynamic responses of the PZT interface-tendon anchorage system. Secondly, experiments on a lab-scaled tendon anchorage are described. Impedance signatures are measured via the PZT interface for a series of temperature and prestress-force changes. Thirdly, temperature effects on measured impedance responses of the tendon anchorage are estimated by quantifying relative changes in impedance features (such as RMSD and CCD indices) induced by temperature variation and prestress-force change. Finally, finite element analyses are conducted to investigate the mechanism of temperature variation and prestress-loss effects on the impedance responses of prestressed tendon anchorage. Temperature effects on impedance monitoring are filtered by effective frequency shift-based algorithm for distinguishing prestress-loss effects on impedance signatures.

76 FR 15246 - Anchorage Regulations; Narragansett Bay and Rhode Island Sound, RI

Science.gov (United States)

2011-03-21

...-AA01 Anchorage Regulations; Narragansett Bay and Rhode Island Sound, RI AGENCY: Coast Guard, DHS... Rhode Island Sound south of Brenton Point, Rhode Island, for use by vessels waiting to enter... Sound that under current informal practice is routinely used by mariners as an anchorage while waiting...

The anchorage capacity of reinforcing bars at normal and high temperatures

DEFF Research Database (Denmark)

Hertz, Kristian Dahl

1982-01-01

of the cross-section. A simple method for calculating the resistance to splitting is proposed, and a test method for determining the bond strength is presented. Test results are shown from a series of 280 specimens exposed to various maximum temperatures, and a relation between the bond strength......The anchorage failure of reinforcing bars is analysed, and it is shown that two modes of failures are possible: splitting or bond failure. It is concluded that the anchorage capacity cannot be estimated by means of a standard specimen, since splitting failure is dependent upon the geometry...... and the ultimate limit stress of concrete under plane strain conditions is indicated. The influence of high temperatures upon the anchorage resistance is explained, and the theory is illustrated by examples....

Improved anchorage of steel linings at WWER nuclear power plants

International Nuclear Information System (INIS)

Bouda, M.; Cepicky, J.

1987-01-01

Three variants were tested of anchoring the steel lining of special structures of nuclear power plants with WWER reactors, such as the containment, viz.: point anchorage with pins according to a Czechoslovak design, and two methods of linear anchorage according to a Soviet design and a design by the Institute for Industrial Construction of the GDR. Graphically shown are some results of the tests of the point anchorage with pins that showed the reliability of the method with respect to deformation and strain of the lining and of the anchoring elements at a lining temperature of up to 300 degC, which significantly exceeded the design-basis accident temperature of 150 degC. The advantages of the variant include a lower content of labour and an increased quality of welding jobs thanks to the application of the Nelson semi-automatic welding technique. (Z.M.). 10 figs., 7 refs

Modification of evaluation response spectrum by ductility of equipment anchorage

International Nuclear Information System (INIS)

Choi, I. G.; Jun, Y. S.; Su, J. M.

2003-01-01

The failure mode of welded anchorage is assumed as brittle in the seismic capacity evaluation of nuclear power plant equipments. But the welded anchorage has some ductile capacity. This limited displacement capacity can cause the reduction of the effective frequency of high frequency equipments and the increase of the inelastic energy absorption capacity due to the nonlinear behavior. In this study, the uniform hazard spectrum for Korean nuclear power plant site was modified using the response spectrum reduction factor developed by EPRI. The spectral acceleration for various damping ratio was determined by the theoretical method based on the random vibration theory. In conclusion, the high frequency components of evaluation response spectra were greatly reduced due to the consideration of welded anchorage ductility. This reduced response spectra can be used for the development of in-structure response spectra used in the seismic capacity evaluation of high frequency equipments

Implants for orthodontic anchorage

Science.gov (United States)

Zheng, Xiaowen; Sun, Yannan; Zhang, Yimei; Cai, Ting; Sun, Feng; Lin, Jiuxiang

2018-01-01

Abstract Implantanchorage continues to receive much attention as an important orthodontic anchorage. Since the development of orthodontic implants, the scope of applications has continued to increase. Although multiple reviews detailing implants have been published, no comprehensive evaluations have been performed. Thus, the purpose of this study was to comprehensively evaluate the effects of implants based on data published in review articles. An electronic search of the Cochrane Library, Medline, Embase, Ebsco and Sicencedirect for reviews with “orthodontic” and “systematic review or meta analysis” in the title, abstract, keywords, or full text was performed. A subsequent manual search was then performed to identify reviews concerning orthodontic implants. A manual search of the orthodontic journals American Journal of Orthodontics and Dentofacial Orthopedics (AJODO), European Journal of Orthodontics (EJO), and Angle Othodontist was also performed. Such systematic reviews that evaluated the efficacy and safety of orthodontic implants were used to indicate success rates and molar movements. A total of 23 reviews were included in the analysis. The quality of each review was assessed using a measurement tool for Assessment of Multiple Systematic Reviews (AMSTAR), and the review chosen to summarize outcomes had a quality score of >6. Most reviews were less than moderate quality. Success rates of implants ranged in a broad scope, and movement of the maxillary first molar was superior with implants compared with traditional anchorage. PMID:29595673

Calculation of absorbed dose of anchorage-dependent cells from internal beta-rays irradiation

International Nuclear Information System (INIS)

Chen Jianwei; Huang Gang; Li Shijun

2001-01-01

Objective: To elicit the formula of internal dosimetry in anchorage-dependent cells by beta-emitting radionuclides from uniformly distributed volume sources. Methods: By means of the definition of absorbed dose and the MIRD (Medical International Radiation Dose) scheme the formula of internal dosimetry was reasonably deduced. Firstly, studying the systems of suspension culture cells. Then, taking account of the speciality of the systems of the anchorage-dependent cells and the directions of irradiation, the absorbed dose of anchorage -dependent cells was calculated by the accumulated radioactivity, beta-ray energy, and the volume of the cultured systems. Results: The formula of internal dosimetry of suspension culture cells and anchorage-dependent cells were achieved. At the same time, the formula of internal dosimetry of suspension culture cells was compared with that of MIRD and was confirmed accurate. Conclusion: The formula of internal dosimetry is concise, reliable and accurate

Water quality and bathymetry of Sand Lake, Anchorage, Alaska

Science.gov (United States)

Donaldson, Donald E.

1976-01-01

Sand Lake, a dimictic lowland lake in Anchorage, Alaska, has recently become as urban lake. Analyses indicate that the lake is oligotrophic, having low dissolved solids and nutrient concentrations. Snowmelt runoff from an adjacent residential area, however, has a dissolved-solids concentration 10 times that of the main body of Sand Lake. Lead concentrations in the runoff exceed known values from other water in the ANchorage area, including water samples taken beneath landfills. The volume of the snowmelt runoff has not been measured. The data presented can be used as a baseline for water-resource management. (Woodard-USGS)

Guidelines for evaluation of anchorage adequacy for safety-related equipment typically used on WWER-type NPPs

International Nuclear Information System (INIS)

Masopust, R.

1999-01-01

This report describes the criteria which should be met when the capacity evaluation of anchorage of safety related equipment is performed for the WWER type NPPs. It should be noted that these criteria were developed specifically for anchorage of WWER type equipment and components to the concrete or steel building structures and they cover different types of anchor bolts and other anchorage details which are typical just for the existing, constructed or reconstructed WWER type NPPs. The screening approach for verifying of equipment anchorage presented in this report is based on a combination of inspections, calculations, and engineering judgement

Feasibility Verification of Mountable PZT-Interface for Impedance Monitoring in Tendon-Anchorage

Directory of Open Access Journals (Sweden)

Thanh-Canh Huynh

2015-01-01

Full Text Available This study has been motivated to numerically evaluate the performance of the mountable PZT-interface for impedance monitoring in tendon-anchorage. Firstly, electromechanical impedance monitoring and feature classification methods are outlined. Secondly, a structural model of tendon-anchorage subsystem with mountable PZT-interface is designed for impedance monitoring. Finally, the feasibility of the mountable PZT-interface is numerically examined. A finite element (FE model is designed for the lab-scaled tendon-anchorage. The FE model of the PZT-interface is tuned as its impedance signatures meet the experimental test results at the same frequency ranges and also with identical patterns. Equivalent model properties of the FE model corresponding to prestress forces inflicted on the lab-tested structure are identified from the fine-tuning practice.

33 CFR 166.200 - Shipping safety fairways and anchorage areas, Gulf of Mexico.

Science.gov (United States)

2010-07-01

... anchorage areas, Gulf of Mexico. 166.200 Section 166.200 Navigation and Navigable Waters COAST GUARD... the erection of structures therein to provide safe approaches through oil fields in the Gulf of Mexico... for Fairway Anchorages in the Gulf of Mexico. Structures may be placed within an area designated as a...

Numerical Simulation and Experimental Validation of an Integrated Sleeve-Wedge Anchorage for CFRP Rods

DEFF Research Database (Denmark)

Schmidt, Jacob Wittrup; Smith, Scott T.; Täljsten, Björn

2011-01-01

. Recently, an integrated sleeve-wedge anchorage has been successfully developed specifically for CFRP rods. This paper in turn presents a numerical simulation of the newly developed anchorage using ABAQUS. The three-dimensional finite element (FE) model, which considers material non-linearity, uses...

Image guided placement of temporary anchorage devices for tooth movement

Energy Technology Data Exchange (ETDEWEB)

Bahl-Palomo, L.; Bissada, N. [Case Western Reserve Univ. School of Dental Medicine, Dept. of Periodontics, Cleveland, OH (United States); Palomo, J.M.; Hans, M.G. [Case Western Reserve Univ. School of Dental Medicine, Dept. of Orthodontics, Cleveland, OH (United States)

2007-06-15

The aim of this project is to develop an image guided protocol for placement of a temporary anchorage device without surgically reflecting a mucoperiosteal flap. Eighteen orthodontic cases were selected for skeletal anchorage from the department of orthodontics at Case University. CBCT images of the subjects were taken using the Hitachi CB MercuRay system set at 15 mA, 120 kVp. CBCT images evaluated the ideal location for TAD placement in three dimensions. Horizontal and vertical linear measurements were taken from fixed dental landmarks to clearly define the location for placement. Transverse slices were used to evaluate the thickness of the buccal plate. Using the transverse view, the angle of insertion was determined such that the maximum buccal plate surface area would contact the screw. TADs were placed in the optimum location, with the most appropriate angle of insertion using a closed approach and with minimal local anesthesia and without flap elevation. Results: All TADs were placed without anatomic encroachment and enabled fixed orthodontic anchorage. (orig.)

Image guided placement of temporary anchorage devices for tooth movement

International Nuclear Information System (INIS)

Bahl-Palomo, L.; Bissada, N.; Palomo, J.M.; Hans, M.G.

2007-01-01

The aim of this project is to develop an image guided protocol for placement of a temporary anchorage device without surgically reflecting a mucoperiosteal flap. Eighteen orthodontic cases were selected for skeletal anchorage from the department of orthodontics at Case University. CBCT images of the subjects were taken using the Hitachi CB MercuRay system set at 15 mA, 120 kVp. CBCT images evaluated the ideal location for TAD placement in three dimensions. Horizontal and vertical linear measurements were taken from fixed dental landmarks to clearly define the location for placement. Transverse slices were used to evaluate the thickness of the buccal plate. Using the transverse view, the angle of insertion was determined such that the maximum buccal plate surface area would contact the screw. TADs were placed in the optimum location, with the most appropriate angle of insertion using a closed approach and with minimal local anesthesia and without flap elevation. Results: All TADs were placed without anatomic encroachment and enabled fixed orthodontic anchorage. (orig.)

Thick-Walled Cylinder Theory Applied on a Conical Wedge Anchorage

DEFF Research Database (Denmark)

Bennitz, Anders; Grip, Niklas; Schmidt, Jacob Wittrup

2011-01-01

for further development of the anchorage.In this paper, we derive and examine an analytical model for the internal stresses and strains within the anchorage for a prescribed presetting distance. This model is derived from the theory of thick walled cylinders under the assumptions regarding plane stress...... and axial symmetry. We simplify the resulting system of ten nonlinear equations and derive a method for solving them numerically. A comparison of plotted results for three different angles on the wedge’s outer surface and six different presetting distances follows.These results are also compared to both axi...

Orthodontic treatment with skeletal anchorage system

Directory of Open Access Journals (Sweden)

Arya Brahmanta

2011-06-01

Full Text Available Background: Correction of class I malocclusion with bimaxillary dental protrusion and unilateral free end right upper ridge in adult patient is one of difficult biomechanical case in orthodontics. Due to this case that needs proper anchorage for upper incisor retraction with missing teeth in the right posterior segment. Purpose: The aim of this study to find an effective therapy for correction of bimaxillary protrusion with unilateral free and ridge. Case: A female patient, 36 year old complaining for the difficulty of lip closure due to severe bimaxillary protrusion with incompetence lip. Case management: Firstly correction of the maxillary and mandibular incisor proclination were done by extraction of the mandibular first premolar, the maxillary second premolar on left side and finally placement of miniplates implant in the zygomatic process on right side as an absolut anchorage. Conclusion: Skeletal anchorage system (SAS can be considered as an effective therapy for corection of bimaxillary protrusion with unilateral free end ridge.Latar belakang: Koreksi dari maloklusi klas I dari penderita dewasa yang disertai protrusi bimaksiler dengan kehilangan gigi posterior pada regio kanan atas merupakan salah satu kasus sulit untuk dikerjakan terutama berhubungan dengan biomekanik pergerakan giginya dalam perawatan ortodonti. Tujuan: Tujuan dari penulisan artikel ini adalah untuk menemukan terapi yang efektif untuk perbaikan protrusi bimaksiler dan kehilangan gigi posterior pada satu sisi. Kasus: Seorang penderita wanita usia 35 tahun datang dengan keluhan utama kesulitan untuk menutup mulut oleh karena gigi rahang atas dan rahang bawahnya maju dan bibirnya tidak kompeten. Tatalaksana kasus: Koreksi pada gigi insisivus rahang atas dan insisivus rahang bawah yang protrusi dilakukan dengan melakukan pencabutan terlebih dahulu pada gigi premolar pertama dirahang bawah sisi kanan dan sisi kiri serta pencabutan pada gigi premolar kedua di rahang atas sisi

33 CFR 162.136 - Connecting waters from Lake Huron to Lake Erie; anchorage grounds.

Science.gov (United States)

2010-07-01

... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Connecting waters from Lake Huron to Lake Erie; anchorage grounds. 162.136 Section 162.136 Navigation and Navigable Waters COAST GUARD... REGULATIONS § 162.136 Connecting waters from Lake Huron to Lake Erie; anchorage grounds. (a) In the Detroit...

Behaviour of Prestressed CFRP Anchorages during and after Freeze-Thaw Cycle Exposure

Directory of Open Access Journals (Sweden)

Yunus Emre Harmanci

2018-05-01

Full Text Available The long-term performance of externally-bonded reinforcements (EBR on reinforced concrete (RC structures highly depends on the behavior of constituent materials and their interfaces to various environmental loads, such as temperature and humidity exposure. Although significant efforts have been devoted to understanding the effect of such conditions on the anchorage resistance of unstressed EBR, with or without sustained loading, the effect of a released prestressing has not been thoroughly investigated. For this purpose, a series of experiments has been carried out herein, with concrete blocks strengthened with carbon fiber-reinforced polymer (CFRP strips, both unstressed, as well as prestressed using the gradient anchorage. The gradient anchorage is a non-mechanical technique to anchor prestressed CFRP by exploiting the accelerated curing property of epoxy under higher temperatures and segment-wise prestress-force releasing. Subsequently, strengthened blocks are transferred into a chamber for exposure in dry freeze-thaw cycles (FTC. Following FTC exposure, the blocks are tested in a conventional lap-shear test setup to determine their residual anchorage resistance and then compared with reference specimens. Blocks were monitored during FTC by conventional and Fabry–Pérot-based fiber optic strain (FOS sensors and a 3D-digital image correlation (3D-DIC system during gradient application and lap-shear testing. Results indicate a reduction of residual anchorage resistance, stiffness and deformation capacity of the system after FTC and a change in the failure mode from concrete substrate to epoxy-concrete interface failure. It was further observed that all of these properties experienced a more significant reduction for prestressed specimens. These findings are presented with a complementary finite element model to shed more light onto the durability of such systems.

A genetic screen for anchorage-independent proliferation in mammalian cells identifies a membrane-bound neuregulin.

Directory of Open Access Journals (Sweden)

Davide Danovi

2010-07-01

Full Text Available Anchorage-independent proliferation is a hallmark of oncogenic transformation and is thought to be conducive to proliferation of cancer cells away from their site of origin. We have previously reported that primary Schwann cells expressing the SV40 Large T antigen (LT are not fully transformed in that they maintain a strict requirement for attachment, requiring a further genetic change, such as oncogenic Ras, to gain anchorage-independence. Using the LT-expressing cells, we performed a genetic screen for anchorage-independent proliferation and identified Sensory and Motor Neuron Derived Factor (SMDF, a transmembrane class III isoform of Neuregulin 1. In contrast to oncogenic Ras, SMDF induced enhanced proliferation in normal primary Schwann cells but did not trigger cellular senescence. In cooperation with LT, SMDF drove anchorage-independent proliferation, loss of contact inhibition and tumourigenicity. This transforming ability was shared with membrane-bound class III but not secreted class I isoforms of Neuregulin, indicating a distinct mechanism of action. Importantly, we show that despite being membrane-bound signalling molecules, class III neuregulins transform via a cell intrinsic mechanism, as a result of constitutive, elevated levels of ErbB signalling at high cell density and in anchorage-free conditions. This novel transforming mechanism may provide new targets for cancer therapy.

Ground Water in the Anchorage Area, Alaska--Meeting the Challenges of Ground-Water Sustainability

Science.gov (United States)

Moran, Edward H.; Galloway, Devin L.

2006-01-01

Ground water is an important component of Anchorage's water supply. During the 1970s and early 80s when ground water extracted from aquifers near Ship Creek was the principal source of supply, area-wide declines in ground-water levels resulted in near record low streamflows in Ship Creek. Since the importation of Eklutna Lake water in the late 1980s, ground-water use has been reduced and ground water has contributed 14-30 percent of the annual supply. As Anchorage grows, given the current constraints on the Eklutna Lake water availability, the increasing demand for water could place an increasing reliance on local ground-water resources. The sustainability of Anchorage's ground-water resources challenges stakeholders to develop a comprehensive water-resources management strategy.

Maxillary incisors changes during space closure with conventional and skeletal anchorage methods: a systematic review.

Science.gov (United States)

Jayaratne, Yasas Shri Nalaka; Uribe, Flavio; Janakiraman, Nandakumar

2017-01-01

The objective of this systematic review was to compare the antero-posterior, vertical and angular changes of maxillary incisors with conventional anchorage control techniques and mini-implant based space closure methods. The electronic databases Pubmed, Scopus, ISI Web of knowledge, Cochrane Library and Open Grey were searched for potentially eligible studies using a set of predetermined keywords. Full texts meeting the inclusion criteria as well as their references were manually searched. The primary outcome data (linear, angular, and vertical maxillary incisor changes) and secondary outcome data (overbite changes, soft tissue changes, biomechanical factors, root resorption and treatment duration) were extracted from the selected articles and entered into spreadsheets based on the type of anchorage used. The methodological quality of each study was assessed. Six studies met the inclusion criteria. The amount of incisor retraction was greater with buccally placed mini-implants than conventional anchorage techniques. The incisor retraction with indirect anchorage from palatal mini-implants was less when compared with buccally placed mini-implants. Incisor intrusion occurred with buccal mini-implants, whereas extrusion was seen with conventional anchorage. Limited data on the biomechanical variables or adverse effects such as root resorption were reported in these studies. More RCT's that take in to account relevant biomechanical variables and employ three-dimensional quantification of tooth movements are required to provide information on incisor changes during space closure.

Experimental evidence of pharmacological management of anchorage in Orthodontics: A systematic review

Science.gov (United States)

Fernández-González, Felipe José; Cañigral, Aránzazu; Balbontín-Ayala, Felipe; Gonzalo-Orden, José Manuel; de Carlos, Felix; Cobo, Teresa; Fernández-Vázquez, Jose Pedro; Sánchez-Lasheras, Fernando; Vega, José Antonio

2015-01-01

Introduction: Orthodontic anchorage is one of the most challenging aspects of Orthodontics. Preventing undesired movement of teeth could result in safer and less complicated orthodontic treatment. Recently, several reviews have been published about the effects of different molecules on bone physiology and the clinical side effects in Orthodontics. However, the effects of local application of these substances on the rate of orthodontic tooth movement have not been assessed. Objectives: The aim of this research was to analyze the scientific evidence published in the literature about the effects of different molecules on orthodontic anchorage. Methods: The literature was systematically reviewed using PubMed/Medline, Scopus and Cochrane databases from 2000 up to July 31st, 2014. Articles were independently selected by two different researchers based on previously established inclusion and exclusion criteria, with a concordance Kappa index of 0.86. The methodological quality of the reviewed papers was performed. Results: Search strategy identified 270 articles. Twenty-five of them were selected after application of inclusion/exclusion criteria, and only 11 qualified for final analysis. Molecules involved in orthodontic anchorage were divided into three main groups: osteoprotegerin (OPG), bisphosphonates (BPs) and other molecules (OMs). Conclusions: Different drugs are able to alter the bone remodeling cycle, influencing osteoclast function and, therefore, tooth movement. Thus, they could be used in order to provide maximal anchorage while preventing undesired movements. OPG was found the most effective molecule in blocking the action of osteoclasts, thereby reducing undesired movements. PMID:26560822

Use of miniplates as a method for orthodontic anchorage: a case report.

Science.gov (United States)

Peres, Fernando Gianzanti; Padovan, Luis Eduardo Marques; Kluppel, Leandro Eduardo; Albuquerque, Gustavo Calvalcanti; Souza, Paulo Cesar Ulson de; Claudino, Marcela

2016-01-01

Temporary anchorage devices (TADs) have been developed to be used as direct adjuncts in orthodontic treatment and have facilitated treatment of more complex orthodontic cases, including patients with dental impaction. This clinical case reports the applicability of TADs in the orthodontic treatment of a patient with impacted mandibular second molars. Surgical and orthodontic procedures related to the use of miniplates were also discussed in this study. The use of temporary anchorage devices, such as miniplates, can be suggested as an alternative to treat patients with impacted mandibular second molars.

Electromechanical impedance-based health diagnosis for tendon and anchorage zone in a nuclear containment structure

Science.gov (United States)

Min, Jiyoung; Shim, Hyojin; Yun, Chung-Bang

2012-04-01

For a nuclear containment structure, the structural health monitoring is essential because of its high potential risk and grave social impact. In particular, the tendon and anchorage zone are to be monitored because they are under high tensile or compressive stress. In this paper, a method to monitor the tendon force and the condition of the anchorage zone is presented by using the impedance-based health diagnosis system. First, numerical simulations were conducted for cases with various loose tensile forces on the tendon as well as damages on the bearing plate and concrete structure. Then, experimental studies were carried out on a scaled model of the anchorage system. The relationship between the loose tensile force and the impedance-based damage index was analyzed by a regression analysis. When a structure gets damaged, the damage index increases so that the status of damage can be identified. The results of the numerical and experimental studies indicate a big potential of the proposed impedance-based method for monitoring the tendon and anchorage system.

75 FR 3641 - Television Broadcasting Services; Anchorage, AK

Science.gov (United States)

2010-01-22

... FEDERAL COMMUNICATIONS COMMISSION 47 CFR Part 73 [DA 10-40; MB Docket No. 09-210; RM-11583] Television Broadcasting Services; Anchorage, AK AGENCY: Federal Communications Commission. ACTION: Final rule... review Act, see 5 U.S.C. 801(a)(1)(A). List of Subjects in 47 CFR Part 73 Television, Television...

Comparative evaluation of sagittal anchorage loss in lingual and labial appliances during space closure: A pilot study

Directory of Open Access Journals (Sweden)

Shivanand Venkatesh

2015-01-01

Full Text Available Aim: The purpose of this investigation was to assess and compare the anchorage loss between labial and lingual appliance systems during space closure. Materials and Methods: Twenty subjects were part of the study among which 10 subjects (mean age 21 ± 3.6 years were treated using lingual appliance system (0.018" slot-STb™ and 10 subjects (mean age 19 ± 6.1 years were treated using labial preadjusted edgewise appliance system (0.018" slot-MBT™ . First premolar extractions were performed to enable retraction of anterior teeth. Lateral cephalometric radiographs were taken at two intervals, before starting space closure and after space closure that were connoted as T0 and T1 and were analyzed using the method described by Pancherz to measure anchorage loss. Intraclass correlation coefficient (ICC was used to evaluate intraexaminer reliability of the measurements. Student′s t-test was performed to verify any statistical significant correlation between the labial and lingual appliance systems. Statistical differences were determined at the 95% confidence level (P < 0.05. Results: The results showed that all ICC for lingual and labial group were ≥0.90 showing good repeatability of the measurements. Mean anchorage loss of 1.238 ± 0.17 mm in lingual appliance system and an anchorage loss of 2.06 ± 0.39 mm occurred with the labial appliance system. On the comparison between the two appliance systems, lingual appliance demonstrated a significantly lesser anchorage loss than did the labial appliance. Interpretation and Conclusion: This prospective study concludes with the fact that lingual appliance provided better anchorage control than labial appliance during space closure. Use of lingual appliance could be considered in critical anchorage cases when compared with labial appliance.

MAXILLARY INCISORS CHANGES DURING SPACE CLOSURE WITH CONVENTIONAL AND SKELETAL ANCHORAGE METHODS: A SYSTEMATIC REVIEW

Directory of Open Access Journals (Sweden)

Yasas Shri Nalaka JAYARATNE

2017-12-01

Full Text Available Purpose: The objective of this systematic review was to compare the antero-posterior, vertical and angular changes of maxillary incisors with conventional anchorage control techniques and mini-implant based space closure methods. Materials and Methods: The electronic databases Pubmed, Scopus, ISI Web of knowledge, Cochrane Library and Open Grey were searched for potentially eligible studies using a set of predetermined keywords. Full texts meeting the inclusion criteria as well as their references were manually searched. The primary outcome data (linear, angular, and vertical maxillary incisor changes and secondary outcome data (overbite changes, soft tissue changes, biomechanical factors, root resorption and treatment duration were extracted from the selected articles and entered into spreadsheets based on the type of anchorage used. The methodological quality of each study was assessed. Results: Six studies met the inclusion criteria. The amount of incisor retraction was greater with buccally placed mini-implants than conventional anchorage techniques. The incisor retraction with indirect anchorage from palatal mini-implants was less when compared with buccally placed mini-implants. Incisor intrusion occurred with buccal mini-implants, whereas extrusion was seen with conventional anchorage. Limited data on the biomechanical variables or adverse effects such as root resorption were reported in these studies. Conclusion: More RCT’s that take in to account relevant biomechanical variables and employ three-dimensional quantification of tooth movements are required to provide information on incisor changes during space closure.

The Plurality of Harbors at Caesarea: The Southern Anchorage in Late Antiquity

Science.gov (United States)

Ratzlaff, Alexandra; Galili, Ehud; Waiman-Barak, Paula; Yasur-Landau, Assaf

2017-08-01

The engineering marvel of Sebastos, or Portus Augusti as it was called in Late Antiquity (284-638 CE), dominated Caesarea's harbor center along modern Israel's central coast but it was only one part of a larger maritime complex. The Southern Anchorage provides a case study as one portion of the Caesarea complex, as well as a node within the regional network of anchorages and small harbors. Ceramics recovered from here show a high percentage of locally, and provincially, produced storage jars engaged in maritime trade. The ceramic evidence points towards an intensified regional trade or cabotage rather than favouring long distance trade from large port to port. Working out of these small harbors, opportunities arose for greater flexibility in specialization of commodities and materials passing through the network of subsidiary ports, contributing to a more diversified market economy. This analysis provides another example in the growing focus on how these simple and semi-modified anchorages in the Eastern Mediterranean were often the predominant economic networks connecting hinterland and coastal trade.

Success rates of a skeletal anchorage system in orthodontics: A retrospective analysis.

Science.gov (United States)

Lam, Raymond; Goonewardene, Mithran S; Allan, Brent P; Sugawara, Junji

2018-01-01

To evaluate the premise that skeletal anchorage with SAS miniplates are highly successful and predictable for a range of complex orthodontic movements. This retrospective cross-sectional analysis consisted of 421 bone plates placed by one clinician in 163 patients (95 female, 68 male, mean age 29.4 years ± 12.02). Simple descriptive statistics were performed for a wide range of malocclusions and desired movements to obtain success, complication, and failure rates. The success rate of skeletal anchorage system miniplates was 98.6%, where approximately 40% of cases experienced mild complications. The most common complication was soft tissue inflammation, which was amenable to focused oral hygiene and antiseptic rinses. Infection occurred in approximately 15% of patients where there was a statistically significant correlation with poor oral hygiene. The most common movements were distalization and intrusion of teeth. More than a third of the cases involved complex movements in more than one plane of space. The success rate of skeletal anchorage system miniplates is high and predictable for a wide range of complex orthodontic movements.

Orthodontic space closure after first molar extraction without skeletal anchorage.

Science.gov (United States)

Jacobs, Collin; Jacobs-Müller, Claudia; Luley, Carolin; Erbe, Christina; Wehrbein, Heiner

2011-03-01

The aim of the study was an analysis of effects and side-effects during mesialization of second molars after extraction of the first permanent molars using the anterior dentition/premolars (PM) as an anchorage unit. A total of 35 patients were examined retrospectively who had undergone unilateral or bilateral first permanent molar extraction in the upper or lower arch due to carious lesions. Space closure was carried out in all cases through mesialization of the second molar using an elastic chain fixed to an edgewise stainless steel archwire and tying the anterior dentition/PM together with a continuous laceback ligature. Tooth movement was assessed from lateral cephalograms, orthopantomograms (OPGs) and images of the patient's study casts taken before and after the end of therapy. Space closure after first molar extractions by mesialization of the second molars without skeletal anchorage was largely achieved by bodily forward movement of the teeth, including a small tipping component or tooth-uprighting component when molars were already mesially inclined. Unilateral and bilateral mesialization of the second molars led to retrusion in the maxilla and mandible [(∆incl.=-3.6° (max., bil.), ∆incl.=-4.2° (mand., bil.)] and to translational retraction [(∆s=-2.3 mm (max., bil.), ∆s=-1.6 mm (mand., bil.)] of the incisors. Examination of the soft tissues revealed an increased posterior displacement of the upper and lower lips to the esthetic line [(∆s=-2.8 mm (max. bil.), ∆s=-2.2 mm (mand., bil.)]. In cases of unilateral mesialization less than 50% of the patients had a slight midline deviation in the mandible towards the extraction side. Side effects during mesialization of the second molars without skeletal anchorage in the anterior dentition/PM were observed primarily affecting the incisors integrated into the anterior anchorage unit. These side-effects resulted in posterior displacement of the soft tissues, including a change in profile. This must be

Fatigue of cable anchorage of large cable stayed bridge; Daikibo shachokyo cable teichaku kozo no hiro

Energy Technology Data Exchange (ETDEWEB)

Endo, T.; Matsumoto, T. [Honshu-Shikoku Bridge Authority, Tokyo (Japan); Tsukahara, H. [Yokogawa Bridge Corp., Tokyo (Japan); Miki, C. [Tokyo Institute of Technology, Tokyo (Japan)

1995-10-21

Design considerations such as design schemes, the assemblage and welding of steel plates, and safety for fatigue of welded connections have to be taken for the cable anchorages of the steel cable stayed bridges. In this study, two full scale models, which have different shape of box anchorages welded to the web of the main girder, were made to investigate fatigue characteristics as well as assemblage of plate and gelding details. Finite element analyses for both test models and actual bridges here carried out to compare stress distribution. It was confirmed that the assemblage and welding of both types of box anchorage were attainable kith required quality and accuracy. According to the fatigue test, fatigue cracks originated from the weldings of the bearing plate to which the load from cable socket applied directly were caused by out-of-plane bending of the bearing plate. It was proved that the slight modifications of the details around the bearing plate resulted in sufficient fatigue strength in both types of anchorage. 1 ref., 23 figs., 2 tabs.

The benefit of differential moment concept in managing posterior anchorage and avoiding bite deepening

Directory of Open Access Journals (Sweden)

Harryanto Wijaya

2012-09-01

Full Text Available Background: Anchorage is one of the major concerns in orthodontic space closure. Various methods have been proposed to enhance posterior anchorage in space closure such as headgear, Nance holding appliance, and micro implant as temporary anchorage devices. However, several issues such as patient's compliance, appliance effectiveness, and cost of the device become many clinicians concern. The differential moment concept in segmented arch is a technique that requires no patient compliance but can effectively manage posterior anchorage and avoid bite deepening by careful application of forces and moments. Purpose: The purpose of this case report is to show the use of differential moment concept in segmented arch technique to manage posterior anchorage and to avoid bite deepening. Case: A 21 years old female patient with protrusive teeth as her chief complaint was treated using fixed orthodontic appliance. Case management: The treatment included four first bicuspid extraction and space closure utilizing differential moment concept in segmented arch. Conclusion: It can be concluded that application of differential moment concept in segmented arch technique is a non invasive, compliance independent, effective, and cost efficient method to manage posterior anchorage and to avoid bite deepening.latar belakang: Penjangkaran merupakan salah satu aspek yang sering kali menjadi masalah dalam penutupan ruang pada perawatan ortodonti. Berbagai metode disarankan untuk memperkuat penjangkaran posterior dalam penutupan ruang seperti headgear, piranti penahan Nance, dan implan mikro sebagai alat penjangkar sementara. Namun demikian, beberapa hal seperti kerjasama pasien, efektivitas piranti, dan biaya dari alat-alat tersebut sering menjadi perhatian/pertimbangan bagi klinisi. Konsep momen diferensial pada segmented arch adalah suatu cara yang efektif untuk memperkuat penjangkaran dan menghindari pendalaman gigitan tanpa memerlukan kerjasama pasien. tujuan

Anchorage of equipment - requirements and verification methods with emphasis on equipment of existing and constructed VVER-type nuclear power plants

International Nuclear Information System (INIS)

Masopust, R.

1999-01-01

Criteria and verification methods which are recommended for use in the capacity evaluation of anchorage of safety-related equipment at WWER-type nuclear power plants are presented. Developed in compliance with the relevant basic standards documents specifically for anchorage of WWER-type equipment components, the criteria and methods cover different types of anchor bolts and other anchorage elements which are typical of existing, constructed, or reconstructed WWER-type nuclear power plants

78 FR 44917 - Anchorage Regulations; Port of New York

Science.gov (United States)

2013-07-25

...-AA01 Anchorage Regulations; Port of New York AGENCY: Coast Guard, DHS. ACTION: Notice of proposed... New York. This action is necessary to facilitate safe navigation and provide safe and secure... this rule, call or email Mr. Jeff Yunker, Sector New York, Waterways Management Division, U.S. Coast...

75 FR 22323 - Anchorage Regulations; Port of New York

Science.gov (United States)

2010-04-28

...-AA01 Anchorage Regulations; Port of New York AGENCY: Coast Guard, DHS. ACTION: Supplemental notice of..., Coast Guard Sector New York, Waterways Management Division; telephone 718-354-4195, e-mail Jeff.M.Yunker... Purpose The Hudson River Pilots Association, through the Port of New York/ New Jersey Harbor Safety...

Herbst appliance with skeletal anchorage versus dental anchorage in adolescents with Class II malocclusion: study protocol for a randomised controlled trial.

Science.gov (United States)

Batista, Klaus Barretto Dos Santos Lopes; Lima, Tatiana; Palomares, Nathália; Carvalho, Felipe de Assis; Quintão, Cátia; Miguel, José Augusto Mendes; Lin, Yin-Ling; Su, Ting-Li; O'Brien, Kevin

2017-11-25

The Herbst appliance is an orthodontic appliance that is used for the correction of class II malocclusion with skeletal discrepancies. Research has shown that this is effective. However, a potential harm is excessive protrusion of the lower front teeth. This is associated with gingival recession, loss of tooth support, and root resorption. This trial evaluates a method of reducing this problem. The study is a single-center, randomised, assessor-blinded, superiority clinical trial with parallel 1:1 allocation. Male and female young people (10-14 years old) with prominent front teeth (class II, division 1) will be treated in one orthodontic clinic. Group 1 will be treated with the conventional Herbst appliance with dental anchorage and group 2 with the Herbst appliance with indirect skeletal anchorage for 12 months. The primary objective will be to compare the proclination of the lower incisors between the Herbst appliance with dental anchorage and skeletal anchorage. Secondary objectives will be to evaluate the changes occurring between the groups in the mandible, maxilla, lower and upper molars, and in gingival recession and root resorption at the end of the treatment. Additionally, the young patient's experience using the appliances will be assessed. The primary outcome measure will be the amount of lower incisor proclination at the end of treatment. This will be assessed by cone-beam computed tomography (CBCT) superimposition. Secondary outcome measures will be the changes in the mandible, maxilla, lower and upper molars at the end of treatment assessed by tomography superimposition and the young patient's experience using the appliances assessed by self-reported questionnaires and semi-structured interviews. The randomisation method will be blocked randomisation, using software to generate a randomised list. The allocation concealment will be done in opaque envelopes numbered from 1 to 40 containing the treatment modality. The randomisation will be

SATB2 expression increased anchorage-independent growth and cell migration in human bronchial epithelial cells

Energy Technology Data Exchange (ETDEWEB)

Wu, Feng; Jordan, Ashley; Kluz, Thomas [Department of Environmental Medicine, New York University School of Medicine, 57 Old Forge Road, Tuxedo, NY 10987 (United States); Shen, Steven [Center for Health Informatics and Bioinformatics, New York University Langone Medical Center, New York, NY 10016 (United States); Sun, Hong; Cartularo, Laura A. [Department of Environmental Medicine, New York University School of Medicine, 57 Old Forge Road, Tuxedo, NY 10987 (United States); Costa, Max, E-mail: Max.Costa@nyumc.org [Department of Environmental Medicine, New York University School of Medicine, 57 Old Forge Road, Tuxedo, NY 10987 (United States)

2016-02-15

The special AT-rich sequence-binding protein 2 (SATB2) is a protein that binds to the nuclear matrix attachment region of the cell and regulates gene expression by altering chromatin structure. In our previous study, we reported that SATB2 gene expression was induced in human bronchial epithelial BEAS-2B cells transformed by arsenic, chromium, nickel and vanadium. In this study, we show that ectopic expression of SATB2 in the normal human bronchial epithelial cell-line BEAS-2B increased anchorage-independent growth and cell migration, meanwhile, shRNA-mediated knockdown of SATB2 significantly decreased anchorage-independent growth in Ni transformed BEAS-2B cells. RNA sequencing analyses of SATB2 regulated genes revealed the enrichment of those involved in cytoskeleton, cell adhesion and cell-movement pathways. Our evidence supports the hypothesis that SATB2 plays an important role in BEAS-2B cell transformation. - Highlights: • We performed SATB2 overexpression in the BEAS-2B cell line. • We performed SATB2 knockdown in a Ni transformed BEAS-2B cell line. • SATB2 induced anchorage-independent growth and increased cell migration. • SATB2 knockdown significantly decreased anchorage-independent growth. • We identified alterations in gene involved in cytoskeleton, cell adhesion.

SATB2 expression increased anchorage-independent growth and cell migration in human bronchial epithelial cells

International Nuclear Information System (INIS)

Wu, Feng; Jordan, Ashley; Kluz, Thomas; Shen, Steven; Sun, Hong; Cartularo, Laura A.; Costa, Max

2016-01-01

The special AT-rich sequence-binding protein 2 (SATB2) is a protein that binds to the nuclear matrix attachment region of the cell and regulates gene expression by altering chromatin structure. In our previous study, we reported that SATB2 gene expression was induced in human bronchial epithelial BEAS-2B cells transformed by arsenic, chromium, nickel and vanadium. In this study, we show that ectopic expression of SATB2 in the normal human bronchial epithelial cell-line BEAS-2B increased anchorage-independent growth and cell migration, meanwhile, shRNA-mediated knockdown of SATB2 significantly decreased anchorage-independent growth in Ni transformed BEAS-2B cells. RNA sequencing analyses of SATB2 regulated genes revealed the enrichment of those involved in cytoskeleton, cell adhesion and cell-movement pathways. Our evidence supports the hypothesis that SATB2 plays an important role in BEAS-2B cell transformation. - Highlights: • We performed SATB2 overexpression in the BEAS-2B cell line. • We performed SATB2 knockdown in a Ni transformed BEAS-2B cell line. • SATB2 induced anchorage-independent growth and increased cell migration. • SATB2 knockdown significantly decreased anchorage-independent growth. • We identified alterations in gene involved in cytoskeleton, cell adhesion.

76 FR 20524 - Anchorage Regulations; Port of New York

Science.gov (United States)

2011-04-13

...-AA01 Anchorage Regulations; Port of New York AGENCY: Coast Guard, DHS. ACTION: Final rule. SUMMARY: The... Yunker, Coast Guard Sector New York, Waterways Management Division; telephone 718-354-4195, e-mail Jeff.M... New York in the Federal Register (74 FR 47906). We received one comment on the NPRM. No public meeting...

Local application of zoledronate for maximum anchorage during space closure.

Science.gov (United States)

Ortega, Adam J A J; Campbell, Phillip M; Hinton, Robert; Naidu, Aparna; Buschang, Peter H

2012-12-01

Orthodontists have used various compliance-dependent physical means such as headgears and intraoral appliances to prevent anchorage loss. The aim of this study was to determine whether 1 local application of the bisphosphonate zoledronate could be used to prevent anchorage loss during extraction space closure in rats. Thirty rats had their maxillary left first molars extracted and their maxillary left second molars protracted into the extraction space with a 10-g nickel-titanium closing coil for 21 days. Fifteen control rats received a local injection of phosphate-buffered saline solution, and 15 experimental rats received 16 μg of the bisphosphonate zoledronate. Bisphosphonate was also delivered directly into the extraction site and left undisturbed for 5 minutes. Cephalograms and incremental thickness gauges were used to measure tooth movements. Tissues were analyzed by microcomputed tomography and histology. The control group demonstrated significant (P <0.05) tooth movements throughout the 21-day period. They showed significantly greater tooth movements than the experimental group beginning in the second week. The experimental group showed no significant tooth movement after the first week. The microcomputed tomography and histologic observations showed significant bone loss in the extraction sites and around the second molars of the controls. In contrast, the experimental group had bone preservation and bone fill. There was no evidence of bisphosphonate-associated osteonecrosis in any sample. A single small, locally applied dose of zoledronate provided maximum anchorage and prevented significant bone loss. Copyright © 2012 American Association of Orthodontists. Published by Mosby, Inc. All rights reserved.

Distinct spinning patterns gain differentiated loading tolerance of silk thread anchorages in spiders with different ecology.

Science.gov (United States)

Wolff, Jonas O; van der Meijden, Arie; Herberstein, Marie E

2017-07-26

Building behaviour in animals extends biological functions beyond bodies. Many studies have emphasized the role of behavioural programmes, physiology and extrinsic factors for the structure and function of buildings. Structure attachments associated with animal constructions offer yet unrealized research opportunities. Spiders build a variety of one- to three-dimensional structures from silk fibres. The evolution of economic web shapes as a key for ecological success in spiders has been related to the emergence of high performance silks and thread coating glues. However, the role of thread anchorages has been widely neglected in those models. Here, we show that orb-web (Araneidae) and hunting spiders (Sparassidae) use different silk application patterns that determine the structure and robustness of the joint in silk thread anchorages. Silk anchorages of orb-web spiders show a greater robustness against different loading situations, whereas the silk anchorages of hunting spiders have their highest pull-off resistance when loaded parallel to the substrate along the direction of dragline spinning. This suggests that the behavioural 'printing' of silk into attachment discs along with spinneret morphology was a prerequisite for the evolution of extended silk use in a three-dimensional space. This highlights the ecological role of attachments in the evolution of animal architectures. © 2017 The Author(s).

Customized lingual bracket system and skeletal anchorage system for open bite correction

Directory of Open Access Journals (Sweden)

Toru Inami

2016-01-01

Full Text Available We treated a female patient with open bite and high-angle Class II Division 2 malocclusion using fully customized lingual appliances, orthodontic anchor screws (OAS, and a skeletal anchorage system (SAS. By carefully controlling torque, anchorage, and vertical skeletal and dental factors, we were able to obtain proper anterior coupling. Even after the retention phase of treatment, the occlusion was maintained, indicating that we provided proper treatment according to the properly designed treatment plan. This also indicates that cases with an extremely high level of difficulty, as in the present case with high-angle retrognathic mandible and open bite, can be treated by combining the Incognito appliance (a fully customized lingual bracket appliance with a SAS and OAS.

Maxillary distraction osteogenesis in cleft lip and palate patients with skeletal anchorage.

Science.gov (United States)

Minami, Katsuhiro; Mori, Yoshihide; Tae-Geon, Kwon; Shimizu, Hidetaka; Ohtani, Miyuki; Yura, Yoshiaki

2007-03-01

Maxillary distraction osteogenesis with the rigid external distraction (RED) system has been used to treat cleft lip and palate (CLP) patients with severe maxillary hypoplasia. We introduce maxillary distraction osteogenesis for CLP patients with skeletal anchorage adapted on a stereolithographic model. Six maxillary deficiency CLP patients treated according to our CLP treatment protocol had undergone maxillary distraction osteogenesis. In all patients, computed tomography (CT) images were recorded preoperatively, and the data were transferred to a workstation. Three-dimensional skeletal structures were reconstructed with CT data sets, and a stereolithographic model was produced. On the stereolithographic model, miniplates were adapted to the surface of maxilla beside aperture piriforms. The operation performed involved a high Le Fort I osteotomy with pterygomaxillary disjunction. Miniplates were fixed to the maxillary segment with three or four screws and used for anchorage of the RED system. Retraction of the maxillary segment was initiated after 1 week. The accuracy of the stereolithographic models was enough to adapt the miniplates so that there was no need to readjust the plates during surgery. Postoperative cephalometric analysis showed that the direction of the retraction was almost parallel to the palatal plane, and dental compensation did not occur. We performed maxillary distraction osteogenesis with skeletal anchorage adapted on the stereolithographic models. Excellent esthetic outcome and skeletal advancement were achieved without dentoalveolar compensations.

Anchorage strategies in geriatric hip fracture management

Directory of Open Access Journals (Sweden)

Knobe Matthias

2016-12-01

Full Text Available There is an enormous humanitarian and socioeconomic need to improve the quality and effectiveness of care for patients with hip fracture. To reduce mechanical complications in the osteosynthesis of proximal femoral fractures, improved fixation techniques have been developed including blade or screw-anchor devices, locked minimally invasive or cement augmentation strategies. However, despite numerous innovations and advances regarding implant design and surgical techniques, systemic and mechanical complication rates remain high. Treatment success depends on secure implant fixation in often-osteoporotic bone as well as on patient-specific factors (fracture stability, bone quality, comorbidity, and gender and surgeon-related factors (experience, correct reduction, and optimal screw placement in the head/neck fragment. For fracture fixation, the anchorage of the lag screw within the femoral head plays a crucial role depending on the implant’s design. Meta-analyses and randomized controlled studies demonstrate that there is a strong trend towards arthroplasty treating geriatric femoral neck fractures. However, for young adults as well as older patients with less compromised bone quality, or in undisplaced fractures, head-preserving therapy is preferred as it is less invasive and associated with good functional results. This review summarizes the evidence for the internal fixation of femoral neck fractures and trochanteric femoral fractures in elderly patients. In addition, biomechanical considerations regarding implant anchorage in the femoral head including rotation, migration, and femoral neck shortening are made. Finally, cement augmentation strategies for hip fracture implants are evaluated critically.

Revisiting the stability of mini-implants used for orthodontic anchorage

Directory of Open Access Journals (Sweden)

Chung-Chen Jane Yao

2015-11-01

Conclusion: This study revealed that once the dental surgeon becomes familiar with the procedure, the stability of orthodontic mini-implants depends on the type of mini-implant, age of the patient, implantation site, and the healing time of the mini-implant. Miniplates are a more feasible anchorage system when miniscrews fail repeatedly.

Clinical application of micro-implant anchorage in initial orthodontic retraction.

Science.gov (United States)

Wahabuddin, Shaji; Mascarenhas, Rohan; Iqbal, Mahamad; Husain, Akhter

2015-02-01

Micro-implant is a device that is temporarily fixed to bone for the purpose of enhancing orthodontic anchorage either by supporting the teeth of the reactive unit or by obviating the need for the reactive unit altogether, and which is subsequently removed after use. The purpose of this study was to evaluate the clinical efficiency of micro-implants in reinforcing anchorage during the initial retraction of anterior teeth, check the rate of initial retraction for 8 weeks, and assess the stability of micro-implants during this period. Eighteen micro-implants were placed (10 in the maxilla and 8 in the mandible) and immediately loaded with 200-250 g of force using 9-mm closed coil Nitinol springs. The amount of space closure was measured every 2 weeks until the eighth week. Cephalometric measurements were made at the end of the study to evaluate anchor loss, if any. Micro-implant stability was also assessed. The rate of initial retraction in the maxilla at the end of 8 weeks was 1.65 mm/quadrant and 1.51 mm/quadrant in the mandible. The amount of retraction on the left side of the arches was 1.66 mm/quadrant and 1.49 mm/quadrant on the right side. The average initial retraction for both arches per month was 0.78 mm. An anchor loss of 0.1 mm (0.06%) was observed in the maxilla while no mandibular anchor loss was recorded. The rate of initial retraction observed in the maxilla was more than that achieved in the mandible. Initial retraction was also more on the left side of the arches. There was no anchor loss in the mandible. The micro-implant-reinforced anchorage was helpful in minimizing anchor loss and accepted heavy traction forces but did not bring about a faster rate of retraction.

A novel anchorage technique for transnasal traction in rigid external maxillary distraction.

Science.gov (United States)

Varol, A; Basa, S

2013-12-01

We describe an effective technique for anchorage of transnasal traction in the management of maxillary rotation during external distraction. Copyright © 2012 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.

Three-dimensional printing spiders: back-and-forth glue application yields silk anchorages with high pull-off resistance under varying loading situations.

Science.gov (United States)

Wolff, Jonas O; Herberstein, Marie E

2017-02-01

The anchorage of structures is a crucial element of construction, both for humans and animals. Spiders use adhesive plaques to attach silk threads to substrates. Both biological and artificial adhesive structures usually have an optimal loading angle, and are prone to varying loading situations. Silk anchorages, however, must cope with loading in highly variable directions. Here we show that the detachment forces of thread anchorages of orb-web spiders are highly robust against pulling in different directions. This is gained by a two-step back-and-forth spinning pattern during the rapid production of the adhesive plaque, which shifts the thread insertion point towards the plaque centre and forms a flexible tree root-like network of branching fibres around the loading point. Using a morphometric approach and a tape-and-thread model we show that neither area, nor width of the plaque, but the shift of the loading point towards the plaque centre has the highest effect on pull-off resistance. This is explained by a circular propagation of the delamination crack with a low peeling angle. We further show that silken attachment discs are highly directional and adjusted to provide maximal performance in the upstream dragline. These results show that the way the glue is applied, crucially enhances the toughness of the anchorage without the need of additional material intake. This work is a starting point to study the evolution of tough and universal thread anchorages among spiders, and to develop bioinspired 'instant' anchorages of thread- and cable-like structures to a broad bandwidth of substrates. © 2017 The Author(s).

Randomized clinical trial comparing control of maxillary anchorage with 2 retraction techniques.

Science.gov (United States)

Xu, Tian-Min; Zhang, Xiaoyun; Oh, Hee Soo; Boyd, Robert L; Korn, Edward L; Baumrind, Sheldon

2010-11-01

The objective of this pilot randomized clinical trial was to investigate the relative effectiveness of anchorage conservation of en-masse and 2-step retraction techniques during maximum anchorage treatment in patients with Angle Class I and Class II malocclusions. Sixty-four growing subjects (25 boys, 39 girls; 10.2-15.9 years old) who required maximum anchorage were randomized to 2 treatment techniques: en-masse retraction (n = 32) and 2-step retraction (n = 32); the groups were stratified by sex and starting age. Each patient was treated by a full-time clinic instructor experienced in the use of both retraction techniques at the orthodontic clinic of Peking University School of Stomatology in China. All patients used headgear, and most had transpalatal appliances. Lateral cephalograms taken before treatment and at the end of treatment were used to evaluate treatment-associated changes. Differences in maxillary molar mesial displacement and maxillary incisor retraction were measured with the before and after treatment tracings superimposed on the anatomic best fit of the palatal structures. Differences in mesial displacement of the maxillary first molar were compared between the 2 treatment techniques, between sexes, and between different starting-age groups. Average mesial displacement of the maxillary first molar was slightly less in the en-masse group than in the 2-step group (mean, -0.36 mm; 95% CI, -1.42 to 0.71 mm). The average mesial displacement of the maxillary first molar for both treatment groups pooled (n = 63, because 1 patient was lost to follow-up) was 4.3 ± 2.1 mm (mean ± standard deviation). Boys had significantly more mesial displacement than girls (mean difference, 1.3 mm; P <0.03). Younger adolescents had significantly more mesial displacement than older adolescents (mean difference, 1.3 mm; P <0.02). Average mesial displacement of the maxillary first molar with 2-step retraction was slightly greater than that for en-masse retraction, but the

A review on the technical basis for ACI 349 code revision to anchorage criteria

International Nuclear Information System (INIS)

Lee, N. H.; You, S. H.

1999-01-01

Anchors are widely used to attach structural and nonstructural elements to concrete in nuclear power plant construction. Anchorage to concrete in nuclear-related structure plant has been designed per ACI 349-90 Appendix B. However, a new criteria for anchorage based on the concrete capacity design(CCD) approach is ready for publication under the normal publication procedures by ACI 349 Code Committee. Both design procedures(ACI 349-90 and ACI 349-New) show rather different concrete capacities. Earlier comparable studies show that the CCD method is a more reliable predictor of concrete breakout than the 45-degree cone method(ACI 349-90), hence the CCD method adopted by ACI 349-New Code has been recommended. The philosophy of the current code is to design ductile fastenings, which requires a limit to guard against brittle concrete failure. On the other hand, the new code requires calculations for the concrete breakout strength, pullout strength, side-face blowout strength of fastener in tension, and concrete breakout strength, pryout strength of fastener in shear. Therefore, the new code can accurately predict the concrete failure capacity for different behavior of the anchorage system. In this review, the provisions of ACI 349-90 and ACI 349-New are compared to show the major differences with emphasis on the concrete breakout capacity

Biofilm formation on surface characterized micro-implants for skeletal anchorage in orthodontics

NARCIS (Netherlands)

Chin, Yeen; Sandham, John; de Vries, Jacob; van der Mei, Henderina; Busscher, Hendrik

Micro-implants are increasingly popular in clinical orthodontics to effect skeletal anchorage. However, biofilm formation on their surfaces and subsequent infection of peri-implant tissues can result in either exfoliation or surgical removal of these devices. The present study aimed to assess

Impedance-Based Cable Force Monitoring in Tendon-Anchorage Using Portable PZT-Interface Technique

Directory of Open Access Journals (Sweden)

Thanh-Canh Huynh

2014-01-01

Full Text Available In this paper, a portable PZT interface for tension force monitoring in the cable-anchorage subsystem is developed. Firstly, the theoretical background of the impedance-based method is presented. A few damage evaluation approaches are outlined to quantify the variation of impedance signatures. Secondly, a portable PZT interface is designed to monitor impedance signatures from the cable-anchorage subsystem. One degree-of-freedom analytical model of the PZT interface is established to explain how to represent the loss of cable force from the change in the electromechanical impedance of the PZT interface as well as reducing the sensitive frequency band by implementing the interface device. Finally, the applicability of the proposed PZT-interface technique is experimentally evaluated for cable force-loss monitoring in a lab-scaled test structure.

Testing of large prestressing tendon end anchorage regions

International Nuclear Information System (INIS)

Johnson, T.E.

1976-01-01

Tests were performed on concrete end anchorage regions for prestressing tendons with ultimate strengths of approximately 8,900 kN. One test structure simulated a full scale concrete containment buttress and the other two test specimens were concrete blocks. The behavior of the test structure and specimens, when subjected to loading, was monitored by strain gages and dial gages. The testing illustrated that all of the amounts of reinforcing tested should be acceptable for the end anchor zones of large tendons presently used in prestressed concrete containment structures. (author)

Evaluating School Wellness Policy in Curbing Childhood Obesity in Anchorage, Alaska

Science.gov (United States)

Parsons, Wendy G.; Garcia, Gabriel M.; Hoffman, Pamela K.

2014-01-01

In 2006, the Anchorage School District implemented a school wellness policy to address the problem of obesity among its elementary-aged students. We assessed whether the addition of this policy is effective in protecting or preventing students from becoming overweight/obese over time. The methods involved following two cohorts of students for 5…

Indian Board of Orthodontics case report: Orthodontic management of vertical excess using skeletal anchorage

Directory of Open Access Journals (Sweden)

Ajit J Kalia

2016-01-01

Full Text Available B.B., a 21-year-old girl, presented with the chief complaint of forwardly placed upper front teeth and gummy smile. Diagnosis revealed prognathic maxilla and average mandible, Class II skeletal base with vertical growth pattern, end-on molars and Class II canine relationship bilaterally, convex profile, potentially incompetent lips, gummy smile, and protrusive lower lip. The patient′s treatment plan was extraction of all first bicuspids and retraction using temporary anchorage devices. Anchorage was reinforced using microimplants in the maxillary arch and second molar banding in the mandibular arch. The implants were placed high up in the vestibule to have more of an intrusive component and to reduce gummy smile at the end of the treatment.

Numerical implementation of multiple peeling theory and its application to spider web anchorages.

Science.gov (United States)

Brely, Lucas; Bosia, Federico; Pugno, Nicola M

2015-02-06

Adhesion of spider web anchorages has been studied in recent years, including the specific functionalities achieved through different architectures. To better understand the delamination mechanisms of these and other biological or artificial fibrillar adhesives, and how their adhesion can be optimized, we develop a novel numerical model to simulate the multiple peeling of structures with arbitrary branching and adhesion angles, including complex architectures. The numerical model is based on a recently developed multiple peeling theory, which extends the energy-based single peeling theory of Kendall, and can be applied to arbitrarily complex structures. In particular, we numerically show that a multiple peeling problem can be treated as the superposition of single peeling configurations even for complex structures. Finally, we apply the developed numerical approach to study spider web anchorages, showing how their function is achieved through optimal geometrical configurations.

Anchorage onto deciduous teeth: effectiveness of early rapid maxillary expansion in increasing dental arch dimension and improving anterior crowding

OpenAIRE

Mutinelli, Sabrina; Manfredi, Mario; Guiducci, Antonio; Denotti, Gloria; Cozzani, Mauro

2015-01-01

Background Anchorage onto permanent dentition is a common procedure in rapid maxillary expansion. However, replacing first permanent molars with the second deciduous molars seems to be an option to reduce some negative side effects during orthodontic treatment. The purpose of this study was to evaluate the dental effect of rapid maxillary expansion with anchorage exclusively onto deciduous teeth performed in the first period of transition. Methods Twenty patients with a lateral cross-bite tre...

Internal structure of mandible around mandibular molar using computed tomography. Anatomical consideration of molar anchorage in orthodontic treatment

International Nuclear Information System (INIS)

Enomoto, Yutaka; Yamashita, Daisuke; Saito, Katsuhiko; Kasai, Kazutaka

2008-01-01

For establishment of fine occlusion, facial profile and oral function in orthodontic treatment, molar anchorage in teeth movement is important manner in extracted cases. The aims of this study were to investigate the relationship between facial morphology and internal structure of mandibular body in molar region by computer tomography, and to discuss about molar anchorage in orthodontic treatment. The data for this study were obtained from 35 modern male Japanese skulls (mean age; 27 year-old, ranged from 18 year-old to 47 year-old). Measurement variables were FMA, SN to mandibular plane angle, gonial angle, alveolar breadth, cortical bone thickness of buccal and lingual sides, and the distance between dental root and cortical bone. As a result, alveolar breadth and the distance between dental root and cortical bone were narrow in long facial type, on the contrary, these variables were wide in short facial type. The result suggested that these variables were considered important factors as molar anchorage in extracted cases. (author)

[Treatment of adult bimaxillary arch protrusion with micro-implant anchorage].

Science.gov (United States)

Chen, Cheng; Zhang, Xiao-Rong

2015-02-01

In this study, micro-implants were used in 15 adult patients with mild and moderate bimaxillary arch protrusion or crowding. Cephalometric analysis was used to analyze hard and soft-tissues change before and after treatment, with the aim to investigate the effects of treatment on adult bimaxillary arch protrusion with micro-implant anchorage. Fifteen adult patients with mild and moderate bimaxillary arch protrusion were selected in this study. Micro-implants were inserted into the zygomaticoalveolar ridge of maxilla and the external oblique line of mandible. A NiTi coil spring was attached to the micro-implant to drag the whole upper and lower dentition for distal movement. Cephalometrics were taken before and after treatment, and the changes of soft and hard-tissue profile were studied. SPSS13.0 software package was used to analyze the data. (1)Sixty micro-implants remained stable.(2)SNA, SNB had no significant changes (P>0.05), and the relationship between the maxilla and the mandible did not change significantly. U1/NA, U1-NA, L1/NB, L1-NB and U1/L1 changes in hard tissue had significant difference in cephalometric measurement (PMicro-implant can provide not only excellent skeletal anchorage but also a novel way to distalize the whole dentition efficiently.

Explaining the democratic anchorage of governance networks

DEFF Research Database (Denmark)

Skelcher, Chris; Klijn, Erik-Hans; Kübler, Daniel

2011-01-01

Advances in understanding the democratic anchorage of governance networks require carefully designed and contextually grounded empirical analysis that take into account contextual factors. The article uses a conjectural framework to study the impact of the national democratic milieu...... on the relationship between network governance and representative institutions in four European countries: the United Kingdom, Switzerland, the Netherlands, and Denmark. The article shows that the distinction between majoritarian and consensus democracy as well as the varying strength of voluntary associations...... are important contextual factors that help explain cross-national differences in the relationship between governance networks and representative institutions. We conclude that a context of weak associationalism in majoritarian democracies facilitates the instrumentalization of networks by government actors...

Barium promotes anchorage-independent growth and invasion of human HaCaT keratinocytes via activation of c-SRC kinase.

Science.gov (United States)

Thang, Nguyen Dinh; Yajima, Ichiro; Kumasaka, Mayuko Y; Ohnuma, Shoko; Yanagishita, Takeshi; Hayashi, Rumiko; Shekhar, Hossain U; Watanabe, Daisuke; Kato, Masashi

2011-01-01

Explosive increases in skin cancers have been reported in more than 36 million patients with arsenicosis caused by drinking arsenic-polluted well water. This study and previous studies showed high levels of barium as well as arsenic in the well water. However, there have been no reports showing a correlation between barium and cancer. In this study, we examined whether barium (BaCl(2)) may independently have cancer-related effects on human precancerous keratinocytes (HaCaT). Barium (5-50 µM) biologically promoted anchorage-independent growth and invasion of HaCaT cells in vitro. Barium (5 µM) biochemically enhanced activities of c-SRC, FAK, ERK and MT1-MMP molecules, which regulate anchorage-independent growth and/or invasion. A SRC kinase specific inhibitor, protein phosphatase 2 (PP2), blocked barium-mediated promotion of anchorage-independent growth and invasion with decreased c-SRC kinase activity. Barium (2.5-5 µM) also promoted anchorage-independent growth and invasion of fibroblasts (NIH3T3) and immortalized nontumorigenic melanocytes (melan-a), but not transformed cutaneous squamous cell carcinoma (HSC5 and A431) and malignant melanoma (Mel-ret) cells, with activation of c-SRC kinase. Taken together, our biological and biochemical findings newly suggest that the levels of barium shown in drinking well water independently has the cancer-promoting effects on precancerous keratinocytes, fibroblast and melanocytes in vitro.

Mini-placa como ancoragem ortodôntica: relato de caso Mini screw as orthodontic anchorage: case report

Directory of Open Access Journals (Sweden)

André Luiz Zétola

2005-08-01

ígida pode ser utilizada com bastante propriedade no tratamento ortodôntico qunado for requerida uma ancoragem máxima.It is needless to say that anchorage control is necessary to a successful orthodontic treatment. Without it, it would be impossible to obtain an ideal occlusion through orthodontic mechanics in the majority of cases. The utilization of rigid devices, originated from face traumatology and implant dentistry principles, to obtain rigid anchorage in orthodontics revolutionized the way of treating cases with an unsatisfactory prognosis. Specially in cases where a lot of anchorage is needed and it is difficult or impossible to get it. The objective of this article was to revise the literature related to the use of mini-screw implant systems, to report a case where it was utilized and to discuss some aspects related to the usage of rigid anchorage orthodontics. The rigid anchorage was used in a 39 year old female patient, who had the upper left molars with a relevant extrusion due to the absence of the lower left molars. Fixed appliances were placed on the upper arch with a TPA connecting the second bicuspids. The TPA was used to anchor the intrusion of the upper left molars. A quad-helix appliance was used to correct the upper right third molar crossbite. Since the orthodontic intrusion with only dental anchorage did not have a satisfactory result, an "L" shaped titanium plate was placed on the maxilla, at the apical region of the upper first and second left molars, with the purpose of obtaining a rigid orthodontic anchorage to intrude them. Elastics were used during five months with intrusive force,the obtained intrusion was 6 millimeters. After the removal of the appliance, upper and lower dental bleaching was made and final prosthesis were placed over the implants. Through the literature reviewed and the case reported, it can be concluded that rigid anchorage can be indicated in orthodontic treatments where there is lack of anchorage or the need of an absolute

Comparison of rate of En masse retraction and anchorage loss in conventional labial appliance with labial and lingual force: A clinical study

Directory of Open Access Journals (Sweden)

Dilshad Quraishi

2018-01-01

Full Text Available Aims: The rate of en masse retraction and anchorage loss were compared between labial appliance with lingual force and conventional labial appliance. Subjects and Methods: The sample consists of 14 patients and they were divided into two groups. In Group 1 – labial appliance with lingual force, elastomeric chain was placed from the palatal surface of the canines to the palatal surface of the molars. In Group 2 – labial appliance with labial force, elastomeric chain was placed from the crimpable hook distal to lateral incisor to the molar tube hooks. The rate of en masse retraction and anchorage loss was calculated for both the groups during retraction in dental casts (R0, initial; R1, 4 weeks; R2, 8 weeks; and R3, 12 weeks. Statistical Analysis Used: Student's paired t-test. Results: The rate of retraction was faster and anchorage loss was lower with labial appliance with lingual force, i.e., Group 1. The difference of anchorage loss in Group 1 and Group 2 shows t = 4.824 and P value= 0.000, which is statistically highly significant. The difference of rate of retraction in Group 1 and Group 2 shows t = 3.573 and P value = 0.004, which is statistically signifcant. Conclusions: The rate of retraction was faster and anchorage loss was lower with labial appliance with lingual force, thus indicating that this new technique of space closure utilizes biomechanical advantage of lingual force in conventional labial appliance.

Disimpaction of maxillary canines using temporary bone anchorage and cantilever springs.

Science.gov (United States)

Thebault, Benoit; Dutertre, Eric

2015-03-01

Impacted canines, particularly in the maxilla, are frequently encountered in orthodontic practice. Unfortunately, depending on their position, correction can often be difficult and sometimes unsuccessful. Thorough diagnosis along with orthodontic treatment combining bone-supported anchorage and cantilever springs appears, in our view, to offer the best solution to this tricky orthodontic challenge while limiting, as far as possible, the risk of failure. Copyright © 2015. Published by Elsevier Masson SAS.

Impact of a new gasoline benzene regulation on ambient air pollutants in Anchorage, Alaska

Science.gov (United States)

Yano, Yuriko; Morris, Stephen S.; Salerno, Christopher; Schlapia, Anne M.; Stichick, Mathew

2016-05-01

The purpose of this study was to quantify the impact of a new U.S. Environmental Protection Agency (EPA) standard that limits the amount of benzene allowed in gasoline on ambient benzene concentrations. This new standard, together with two companion regulations that limit cold-temperature automotive emissions and the permeability of portable fuel containers, was expected to lower the levels of ambient benzene and other volatile organic compounds (VOCs) nationwide. In this study the impact of the gasoline benzene standard was evaluated in Anchorage, Alaska in a two-phase ambient air monitoring study conducted before and after the new gasoline standard was implemented. Gasoline sold by Anchorage retailers was also evaluated in each phase to determine the content of benzene and other gasoline components. The average benzene content in Anchorage gasoline was reduced by 70%, from 5.05% (w/w) to 1.53% (w/w) following the implementation of the standard. The annual mean ambient benzene concentration fell by 51%, from 0.99 ppbv in Phase 1 to 0.49 ppbv in Phase 2. Analysis suggests the change in gasoline benzene content alone reduced benzene emissions by 46%. The changes in toluene, ethylbenzene, and xylene content in gasoline between Phase 1 and 2 were relatively small and the differences in the mean ambient concentrations of these compounds between phases were modest. Our results suggest that cold winter communities in high latitude and mountainous regions may benefit more from the gasoline benzene standard because of high benzene emissions resulting from vehicle cold start and a tendency to develop atmospheric stagnation conditions in the winter.

Strontium ranelate improved tooth anchorage and reduced root resorption in orthodontic treatment of rats.

Science.gov (United States)

Kirschneck, Christian; Wolf, Michael; Reicheneder, Claudia; Wahlmann, Ulrich; Proff, Peter; Roemer, Piero

2014-12-05

The anchorage mechanisms currently used in orthodontic treatment have various disadvantages. The objective of this study was to determine the applicability of the osteoporosis medication strontium ranelate in pharmacologically induced orthodontic tooth anchorage. In 48 male Wistar rats, a constant orthodontic force of 0.25 N was reciprocally applied to the upper first molar and the incisors by means of a Sentalloy(®) closed coil spring for two to four weeks. 50% of the animals received strontium ranelate at a daily oral dosage of 900 mg per kilogramme of body weight. Bioavailability was determined by blood analyses. The extent of tooth movement was measured both optometrically and cephalometrically (CBCT). Relative alveolar gene expression of osteoclastic markers and OPG-RANKL was assessed by qRT-PCR and root resorption area and osteoclastic activity were determined in TRAP-stained histologic sections of the alveolar process. Compared to controls, the animals treated with strontium ranelate showed up to 40% less tooth movement after four weeks of orthodontic treatment. Gene expression and histologic analyses showed significantly less osteoclastic activity and a significantly smaller root resorption area. Blood analyses confirmed sufficient bioavailability of strontium ranelate. Because of its pharmacologic effects on bone metabolism, strontium ranelate significantly reduced tooth movement and root resorption in orthodontic treatment of rats. Strontium ranelate may be a viable agent for inducing tooth anchorage and reducing undesired root resorption in orthodontic treatment. Patients under medication of strontium ranelate have to expect prolonged orthodontic treatment times. Copyright © 2014 Elsevier B.V. All rights reserved.

Root perforation associated with the use of a miniscrew implant used for orthodontic anchorage: a case report.

Science.gov (United States)

McCabe, P; Kavanagh, C

2012-07-01

To highlight one of the possible complications associated with the inter-radicular placement of orthodontic miniscrews. This case report describes the endodontic treatment and surgical repair of an iatrogenic root perforation involving a maxillary first molar tooth following the placement of an orthodontic miniscrew placed for anchorage purposes in the treatment of an adult patient. The orthodontic treatment plan was completed. The long-term follow-up shows a successful treatment outcome. Inter-radicular placement of orthodontic miniscrews is a valuable source of anchorage in the treatment of orthodontic patients. Root perforation is a possible complication from inter-radicular placement of orthodontic miniscrews. Root perforation can be successfully treated, but may involve apical surgery. © 2012 International Endodontic Journal.

[Comparing the anchorage effects of micro-implant and J hook on treating patients with maxillary protrusion].

Science.gov (United States)

Wu, Xin; Liu, Guo-yuan; Jiang, Yong-lian

2015-10-01

To investigate the differences in anchorage effects between micro-implants and J hook in treating patients with Class II division 1 maxillary protrusion. Thirty-one cases of adult patients with Class II division 1 maxillary protrusion were treated. They were divided into 2 groups depending on their selection. The first group included 17 patients for micro-implant anchorage, who adopted micro-implant and sliding mechanism to close maxillary extraction space and depress the mandibular molar. The second group encompassed 14 cases for J hook, who adopted sliding mechanism, J hooks in high traction and Class II intermaxillary traction to close extraction space. X-ray lateral cephalometric radiographs were measured before and after treatment, and SPSS16.0 software package was employed to compare the differences in soft and hard tissue changes before and after treatment between 2 groups. There were statistically significant differences in SNB, ANB, MP-FH, U1-Y, U6-Y, L6-MP, NLA, and UL-Y between the 2 groups before and after treatment, while there was no significant difference in SNA, U1-SN, U1-X, and U6-X between the 2 groups. In treating patients with Class II division 1 maxillary protrusion, micro-implant has stronger anchorage effects than J hook, while at the same time depressing the mandibular molars, and making it more favorable to improve Class II faces.

Skeletal anchorage in orthodontics : A review of various systems in animal and human studies

NARCIS (Netherlands)

Janssen, Krista I.; Raghoebar, Gerry M.; Vissink, Arjan; Sandham, John

2008-01-01

Purpose: The aim of the present investigation was to review and evaluate the current literature on skeletal bone anchorage in orthodontics with regard to success rates of the various systems. Materials and Methods: MEDLINE, PubMed, and Cochrane searches (period January 1966 to January 2006, English

Role for cER and Mmr1p in anchorage of mitochondria at sites of polarized surface growth in budding yeast.

Science.gov (United States)

Swayne, Theresa C; Zhou, Chun; Boldogh, Istvan R; Charalel, Joseph K; McFaline-Figueroa, José Ricardo; Thoms, Sven; Yang, Christine; Leung, Galen; McInnes, Joseph; Erdmann, Ralf; Pon, Liza A

2011-12-06

Mitochondria accumulate at neuronal and immunological synapses and yeast bud tips and associate with the ER during phospholipid biosynthesis, calcium homeostasis, and mitochondrial fission. Here we show that mitochondria are associated with cortical ER (cER) sheets underlying the plasma membrane in the bud tip and confirm that a deletion in YPT11, which inhibits cER accumulation in the bud tip, also inhibits bud tip anchorage of mitochondria. Time-lapse imaging reveals that mitochondria are anchored at specific sites in the bud tip. Mmr1p, a member of the DSL1 family of tethering proteins, localizes to punctate structures on opposing surfaces of mitochondria and cER sheets underlying the bud tip and is recovered with isolated mitochondria and ER. Deletion of MMR1 impairs bud tip anchorage of mitochondria without affecting mitochondrial velocity or cER distribution. Deletion of the phosphatase PTC1 results in increased Mmr1p phosphorylation, mislocalization of Mmr1p, defects in association of Mmr1p with mitochondria and ER, and defects in bud tip anchorage of mitochondria. These findings indicate that Mmr1p contributes to mitochondrial inheritance as a mediator of anchorage of mitochondria to cER sheets in the yeast bud tip and that Ptc1p regulates Mmr1p phosphorylation, localization, and function. Copyright © 2011 Elsevier Ltd. All rights reserved.

1964 Great Alaska Earthquake: a photographic tour of Anchorage, Alaska

Science.gov (United States)

Thoms, Evan E.; Haeussler, Peter J.; Anderson, Rebecca D.; McGimsey, Robert G.

2014-01-01

On March 27, 1964, at 5:36 p.m., a magnitude 9.2 earthquake, the largest recorded earthquake in U.S. history, struck southcentral Alaska (fig. 1). The Great Alaska Earthquake (also known as the Good Friday Earthquake) occurred at a pivotal time in the history of earth science, and helped lead to the acceptance of plate tectonic theory (Cox, 1973; Brocher and others, 2014). All large subduction zone earthquakes are understood through insights learned from the 1964 event, and observations and interpretations of the earthquake have influenced the design of infrastructure and seismic monitoring systems now in place. The earthquake caused extensive damage across the State, and triggered local tsunamis that devastated the Alaskan towns of Whittier, Valdez, and Seward. In Anchorage, the main cause of damage was ground shaking, which lasted approximately 4.5 minutes. Many buildings could not withstand this motion and were damaged or collapsed even though their foundations remained intact. More significantly, ground shaking triggered a number of landslides along coastal and drainage valley bluffs underlain by the Bootlegger Cove Formation, a composite of facies containing variably mixed gravel, sand, silt, and clay which were deposited over much of upper Cook Inlet during the Late Pleistocene (Ulery and others, 1983). Cyclic (or strain) softening of the more sensitive clay facies caused overlying blocks of soil to slide sideways along surfaces dipping by only a few degrees. This guide is the document version of an interactive web map that was created as part of the commemoration events for the 50th anniversary of the 1964 Great Alaska Earthquake. It is accessible at the U.S. Geological Survey (USGS) Alaska Science Center website: http://alaska.usgs.gov/announcements/news/1964Earthquake/. The website features a map display with suggested tour stops in Anchorage, historical photographs taken shortly after the earthquake, repeat photography of selected sites, scanned documents

77 FR 8252 - Adequacy Status of the Anchorage, Alaska, Carbon Monoxide Maintenance Plan for Transportation...

Science.gov (United States)

2012-02-14

... a SIP means that transportation activities will not produce new air quality violations, worsen... Anchorage, Alaska, Carbon Monoxide Maintenance Plan for Transportation Conformity Purposes AGENCY... Transportation & Public Facilities, and the U.S. Department of Transportation will be required to use [[Page 8253...

Anchorage failure of young trees in sandy soils is prevented by a rigid central part of the root system with various designs

Science.gov (United States)

Danquechin Dorval, Antoine; Meredieu, Céline; Danjon, Frédéric

2016-01-01

Background and Aims Storms can cause huge damage to European forests. Even pole-stage trees with 80-cm rooting depth can topple. Therefore, good anchorage is needed for trees to survive and grow up from an early age. We hypothesized that root architecture is a predominant factor determining anchorage failure caused by strong winds. Methods We sampled 48 seeded or planted Pinus pinaster trees of similar aerial size from four stands damaged by a major storm 3 years before. The trees were gathered into three classes: undamaged, leaning and heavily toppled. After uprooting and 3D digitizing of their full root architectures, we computed the mechanical characteristics of the main components of the root system from our morphological measurements. Key Results Variability in root architecture was quite large. A large main taproot, either short and thick or long and thin, and guyed by a large volume of deep roots, was the major component that prevented stem leaning. Greater shallow root flexural stiffness mainly at the end of the zone of rapid taper on the windward side also prevented leaning. Toppling in less than 90-cm-deep soil was avoided in trees with a stocky taproots or with a very big leeward shallow root. Toppled trees also had a lower relative root biomass – stump excluded – than straight trees. Conclusions It was mainly the flexural stiffness of the central part of the root system that secured anchorage, preventing a weak displacement of the stump. The distal part of the longest taproot and attached deep roots may be the only parts of the root system contributing to anchorage through their maximum tensile load. Several designs provided good anchorage, depending partly on available soil depth. Pole-stage trees are in-between the juvenile phase when they fail by toppling and the mature phase when they fail by uprooting. PMID:27456136

Silver oxide-containing hydroxyapatite coating supports osteoblast function and enhances implant anchorage strength in rat femur.

Science.gov (United States)

Eto, Shuichi; Miyamoto, Hiroshi; Shobuike, Takeo; Noda, Iwao; Akiyama, Takayuki; Tsukamoto, Masatsugu; Ueno, Masaya; Someya, Shinsuke; Kawano, Shunsuke; Sonohata, Motoki; Mawatari, Masaaki

2015-09-01

Antibacterial silver with hydroxyapatite (Ag-HA) is a promising coating material for imparting antibacterial properties to implants. We previously reported that 3% (w/w) silver with HA (3% Ag-HA) has both antibacterial activity and osteoconductivity. In this study, we investigated the effects of Ag-HA on the in vitro osteoblast function and the in vivo anchorage strength and osteoconductivity of implants. Production of the osteoblast marker alkaline phosphatase, but not cytotoxicity, was observed in cells of the osteoblast cell line MC3T3-E1 cultured on the 3% Ag-HA-coated surface. These results were similar to those observed with silver-free HA coating. In contrast, a significant high level of cytotoxicity was observed when the cells were cultured on a 50% Ag-HA-coated surface. The anchorage strength of implants inserted into the femur of Sprague-Dawley (SD) rats was enhanced by coating the implants with 3% Ag-HA. On the 3% Ag-HA-coated surface, both metaphyseal and diaphyseal areas were largely covered with new bone and had adequate osteoconductivity. These results suggest that 3% Ag-HA, like conventional HA, promotes osteogenesis by supporting osteoblast viability and function and thereby contributes to sufficient anchorage strength of implants. Application of 3% Ag-HA, which combines the osteoconductivity of HA and the antibacterial activity of silver, to prosthetic joints will help prevent postoperative infections. © 2015 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.

Ground-water quality beneath solid-waste disposal sites at anchorage, Alaska

Science.gov (United States)

Zenone, Chester; Donaldson, D.E.; Grunwaldt, J.J.

1975-01-01

Studies at three solid-waste disposal sites in the Anchorage area suggest that differences in local geohydrologic conditions influence ground-water quality. A leachate was detected in ground water within and beneath two sites where the water table is very near land surface and refuse is deposited either at or below the water table in some parts of the filled areas. No leachate was detected in ground water beneath a third site where waste disposal is well above the local water table.

[Comparison between J-hook and micro-implant anchorage in the treatment of patients with bimaxillary protrusion].

Science.gov (United States)

Chen, Wen-Jing; Li, Qing-Yi; Gong, Ai-Xiu; Hu, Fang; Gu, Yong-Jia

2008-02-01

To compare the difference between J-hook and micro-implant anchorage in the treatment of patient with bimaxillary protrusion. Thirty patients with bimaxillary protrusion were divided into two groups (J-hook and micro-implant groups) and treated with MBT appliance. Four first premolars were extracted in all patients. Cephalometric analyses were carried out before and after treatment. In J-hook group and micro-implant group,computerized cephalometric analysis revealed that before treatment U6C-PP was (12.4 +/- 0.2) mm and (12.5 +/- 0.1) mm, respectively,and after treatment U6C-PP was (12.6 +/- 0.1) mm and (12.8 +/- 0.1) mm,respectively. The difference between J-hook group and microimplant group was significant (P micro-implant group was not significant. Both J-hook and micro-implant could provide adequate anchorage in the treatment of patients with bimaxillary protrusion.

Management of post midface distraction occlusal discrepancy using temporary anchorage devices in a cleft patient

Science.gov (United States)

Koteswara Prasad, N. K.; Hussain, Syed Altaf; Chitharanjan, Arun B.; Murthy, Jyotsna

2015-01-01

Open bite deformity following a successful midface advancement by distraction osteogenesis is a common complication. Temporary anchorage devices can be deployed during the distraction and post-distraction settling phases for restoring the occlusion even in severe cases. The following report describes the management of severe anterior open bite following maxillary distraction. PMID:25991895

Modified Miniplates for Temporary Skeletal Anchorage in Orthodontics: Placement and Removal Surgeries

Science.gov (United States)

Cornelis, Marie A.; Scheffler, Nicole R.; Mahy, Pierre; Siciliano, Sergio; De Clerck, Hugo J.; Tulloch, J.F. Camilla

2009-01-01

Purpose Skeletal anchorage systems are increasingly used in orthodontics. This article describes the techniques of placement and removal of modified surgical miniplates used for temporary orthodontic anchorage and reports surgeons’ perceptions of their use. Patients and Methods We enrolled 97 consecutive orthodontic patients having miniplates placed as an adjunct to treatment. A total of 200 miniplates were placed by 9 oral surgeons. Patients and surgeons completed questionnaires after placement and removal surgeries. Results Fifteen miniplates needed to be removed prematurely. Antibiotics and anti-inflammatories were generally prescribed after placement but not after removal surgery. Most surgeries were performed with the patient under local anesthesia. Placement surgery lasted on average between 15 and 30 minutes per plate and was considered by the surgeons to be very easy to moderately easy. The surgery to remove the miniplates was considered easier and took less time. The patients’ chief complaint was swelling, lasting on average 5.3 ± 2.8 days after placement and 4.5 ± 2.6 days after removal. Conclusions Although miniplate placement/removal surgery requires the elevation of a flap, this was considered an easy and relatively short surgical procedure that can typically be performed with the patient under local anesthesia without complications, and it may be considered a safe and effective adjunct for orthodontic treatment. PMID:18571028

A Manual for the Anchorage School District Bilingual Education Program Revised Scope and Sequence, K-3.

Science.gov (United States)

Heinrich, Maria Nieves Bumanlag Lilagan

The manual offers a systematic set of procedures and relevant information to facilitate effective use of the Anchorage school district (ASD) bilingual education program (BEP). The historical background of the program's development is presented, available manuals for teaching English to limited English proficiency (LEP) students and related…

Management of post midface distraction occlusal discrepancy using temporary anchorage devices in a cleft patient

Directory of Open Access Journals (Sweden)

N K Koteswara Prasad

2015-01-01

Full Text Available Open bite deformity following a successful midface advancement by distraction osteogenesis is a common complication. Temporary anchorage devices can be deployed during the distraction and post-distraction settling phases for restoring the occlusion even in severe cases. The following report describes the management of severe anterior open bite following maxillary distraction.

Mini-screw implant or transpalatal arch-mediated anchorage reinforcement during canine retraction: a randomized clinical trial.

Science.gov (United States)

Sharma, Mohit; Sharma, Vineet; Khanna, Bharat

2012-06-01

To compare mesial movement of upper first molars during maxillary canine retraction using a pre-adjusted edgewise appliance provided by anchorage reinforcement and a transpalatal arch or mini-screw implant. Randomized clinical trial. Department of Orthodontics and Dentofacial Orthopedics, Armed Forces Medical College, Pune, India. From a cohort of subjects requiring the extraction of both upper first premolars and pre-adjusted edgewise appliances to correct their malocclusion, a total of 30 were randomly allocated to receive two different forms of anchorage reinforcement: group A--receiving mini-screw implant and group B--receiving a transpalatal arch Group A subjects received titanium mini-screw implants placed at the start of treatment between the maxillary second premolar and maxillary first molar. Maxillary second premolars were secured to the mini-screw implants using of 0.010-inch stainless steel ligature wire. Group B subjects received a custom-made transpalatal arch which was soldered to maxillary first molar bands. Active canine retraction was initiated in both groups on placement of a 0.019×0.025-inch stainless steel archwire using nickel titanium closed coil springs. Mesial movement of the upper first molars as measured on pre- (T1) and post-treatment (T2) lateral skull radiographs. The results showed that in group A the mean mesial movement of the first molars between T1 and T2 was 0.0 mm (SD 0.02; P = 0.90), whereas in Group B there was a mean forward movement of the first maolars of 2.48 mm (SD 0.71; Pimplants placed prior to levelling and aligning were able to provide absolute anchorage during maxillary canine retraction, in contrast to a transpalatal arch.

Orthodontic retreatment using anchorage with miniplate to camouflage a Class III skeletal pattern

OpenAIRE

Farret,Marcel Marchiori

2016-01-01

ABSTRACT This manuscript describes the treatment of a 27-year-old patient who was previously treated with two maxillary first premolar extractions. The patient had skeletal Class III malocclusion, Class III canine relationship, anterior crossbite, and a concave profile. As the patient refused orthognathic surgery, a miniplate was used on the right side of the lower arch as an anchorage unit after the extraction of mandibular first premolars, aiding the retraction of anterior teeth. At the end...

Dental Extrusion with Orthodontic Miniscrew Anchorage: A Case Report Describing a Modified Method

OpenAIRE

Horliana, Ricardo Fidos; Horliana, Anna Carolina Ratto Tempestini; Wuo, Alexandre do Vale; Perez, Fl?vio Eduardo Guillin; Abr?o, Jorge

2015-01-01

In recent years, the skeletal anchorage through miniscrews has expanded the treatment options in orthodontics (Yamaguchi et al., 2012). We hereby present a modified method for tooth extrusion for cases where crown-lengthening surgery is contraindicated for aesthetic reasons. This modified method uses three orthodontic appliances: a mini-implant, an orthodontic wire, and a bracket. The aim of this case report was to increase the length of the clinical crown of a fractured tooth (tooth 23) by m...

77 FR 35104 - Notice of Request To Release Airport Property at Merrill Field Airport, Anchorage, AK

Science.gov (United States)

2012-06-12

... delivered to: Michelle Colby, Real Estate Services Manager, DOWL HKM, 4041 B Street, Anchorage, AK 99503...- 271-3665, email [email protected] or Michelle Colby, Real Estate Services Manager, DOWL HKM, 4041... Section 6.13 of the State of Alaska Right of Way Manual. This purchase offer was predicated on DOT&PF's...

Transfer and anchorage bond behaviour in self-compacting concrete

Directory of Open Access Journals (Sweden)

Rigueira-Víctor, J. W.

2006-12-01

Full Text Available Self-compacting concretes (SCC provide solutions to the problems facing precast concrete construction, enhancing competitiveness, reducing turnaround times and improving final product quality. SCC is fast becoming a key product for the future development of the precast pre-stressed concrete industry.The present paper compares the bond performance of SCC and traditional concrete (TC. The bond performance results confirm the viability of SCC in precast pre-stressed concrete manufacture, despite a slightly higher loss of pre-stressing force and slightly greater anchorage lengths in SCC with a low water/cement ratio. No differences in transfer or anchorage length were detected,however, when high strength TC and SCC were compared. The ECADA test method proved to be well suited to detecting the differences between the concretes analyzed.El desarrollo de los hormigones autocompactantes (SCCofrece muchas posibilidades a las construcciones con hormigón prefabricado, aumentando su competitividad, reduciéndolos plazos de fabricación y ofreciendo mejoras en la calidad del producto final. El SCC se está convirtiendo en un producto clave para el futuro desarrollo de la industria de prefabricados de hormigón pretensado.En este estudio se compara el comportamiento adherente de los SCC con el de los hormigones tradicionales (TC actuales. Los resultados obtenidos confirman la viabilidad del uso de los SCC para la fabricación de elementos prefabricados con hormigón pretensado, en lo relativo a su comportamiento adherente, aunque con la necesidad de considerar unas pérdidas de pretensado ligeramente mayores. Asimismo,debe esperarse un ligero aumento de las longitudes de anclaje cuando se trabaje con SCC de baja relación agua/cemento. Sin embargo, no se han detectado diferencias de comportamiento entre ambos tipos de hormigón cuando la resistencia a compresión es alta en lo relativo a las longitudes de transmisión y anclaje. El método de ensayo ECADA

Digital lingual orthodontics and temporary anchorage devices for efficient biomechanics

Directory of Open Access Journals (Sweden)

Pravin Shetty

2016-01-01

Full Text Available Adult patients seeking orthodontic treatment at all times present with an esthetic demand even during treatment. The lingual orthodontics, apart from its esthetic values, also presents several other advantages. Currently, it has become a complete system in itself, starting from an accurate diagnosis, treatment protocol, and laboratory procedure to placement of the appliance in the patient′s mouth. With the advent of computer-aided design/computer-aided manufacturing system, the lingual orthodontics is more evolved and made ease operators in respect to more efficient mechanics and reduced archwire adjustments. The present article presents two cases to show the efficiency of lingual orthodontics with temporary anchorage devices and anterior retraction hook.

Verification of the local structural response of building structures in the anchorage areas of heavy components

International Nuclear Information System (INIS)

Krutzik, N.J.; Tropp, R.

1989-01-01

In conventional dynamic structural analyses for determining dynamic system response for various locations at which components are installed inside the structures it is common practice (in order to simplify analytical effort) to assume that the anchorage (anchor plate, anchor bolts or throughbolts, concrete and reinforcement in the area of bound) has rigid body characteristics and that the building structure itself does not display any local response of its own. The influence of the stiffness of the anchor plate as well anchor bolts and its stress level on the dynamic response is also neglected. For a large number of anchoring systems, especially for all those components and systems having only a small mass, this assumption is certainly appropriate. At some locations, particularly at points where heavy components are anchored or when loading input has been increased, this can lead to local loading of the anchor system as well as of the building structure well into the nonlinear range. Often, verification of capability to accommodate these loads is not possible without changing the wall thicknesses or increasing the percentage of reinforcement. Since the presence of linear or nonlinear effects can be expected to result in energy dissipation (increase in damping capacity and also a change in the stiffness of the coupled system) it must be assumed that the dynamic response between the theoretical coupling point A and the real connection point B of the component on the anchor plate can be considerably altered. Some changes of the dynamic response in the connection point B have to be expected generally even in cases of linear-elastic loading of the anchorage. Using typical anchoring systems as an example, the influence of consideration of nonlinear effects in the anchorage area of a typical anchor plate on the dynamic response as well as the conservatism of conventional analytical approaches are investigated

78 FR 11745 - Anchorages; Lower Mississippi River, Above Head of Passes, Convent, LA and Point Pleasant, LA

Science.gov (United States)

2013-02-20

... able to maneuver in, around, and through the anchorage. Operators who choose to maneuver their vessels... respects the First Amendment rights of protesters. Protesters are asked to contact the person listed in the FOR FURTHER INTFORMATION CONTACT section to coordinate protest activities so that your message can be...

Bioreactor design for successive culture of anchorage-dependent cells operated in an automated manner.

Science.gov (United States)

Kino-Oka, Masahiro; Ogawa, Natsuki; Umegaki, Ryota; Taya, Masahito

2005-01-01

A novel bioreactor system was designed to perform a series of batchwise cultures of anchorage-dependent cells by means of automated operations of medium change and passage for cell transfer. The experimental data on contamination frequency ensured the biological cleanliness in the bioreactor system, which facilitated the operations in a closed environment, as compared with that in flask culture system with manual handlings. In addition, the tools for growth prediction (based on growth kinetics) and real-time growth monitoring by measurement of medium components (based on small-volume analyzing machinery) were installed into the bioreactor system to schedule the operations of medium change and passage and to confirm that culture proceeds as scheduled, respectively. The successive culture of anchorage-dependent cells was conducted with the bioreactor running in an automated way. The automated bioreactor gave a successful culture performance with fair accordance to preset scheduling based on the information in the latest subculture, realizing 79- fold cell expansion for 169 h. In addition, the correlation factor between experimental data and scheduled values through the bioreactor performance was 0.998. It was concluded that the proposed bioreactor with the integration of the prediction and monitoring tools could offer a feasible system for the manufacturing process of cultured tissue products.

Mechanical anchorage of FRP tendons – A literature review

DEFF Research Database (Denmark)

Schmidt, Jacob W.; Bennitz, Anders; Täljsten, Björn

2012-01-01

High tensile strength, good resistance to degradation and creep, low weight and, to some extent, the ability to change the modulus of elasticity are some of the advantages of using prestressed, unidirectional FRP (Fibre Reinforced Polymer) tendon systems. Bonded and non-bonded versions of these s......High tensile strength, good resistance to degradation and creep, low weight and, to some extent, the ability to change the modulus of elasticity are some of the advantages of using prestressed, unidirectional FRP (Fibre Reinforced Polymer) tendon systems. Bonded and non-bonded versions...... with such systems. This is especially important in external post-tensioned tendon systems, where the anchorage points are exposed to the full load throughout the life span of the structure. Consequently, there are large requirements related to the long-term capacity and fatigue resistance of such systems. Several...

33 CFR 110.236 - Pacific Ocean off Barbers Point, Island of Oahu, Hawaii: Offshore pipeline terminal anchorages.

Science.gov (United States)

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Pacific Ocean off Barbers Point... Grounds § 110.236 Pacific Ocean off Barbers Point, Island of Oahu, Hawaii: Offshore pipeline terminal... regulations. (1) No vessels may anchor, moor, or navigate in anchorages A, B, C, or D except: (i) Vessels...

Asymmetrical distalization of maxillary molars with zygomatic anchorage, improved superelastic nickel-titanium alloy wires, and open-coil springs.

Science.gov (United States)

Ishida, Takayoshi; Yoon, Hyung Sik; Ono, Takashi

2013-10-01

In nongrowing patients with skeletal Class II malocclusion, premolar extraction or maxillary distalization can be used as camouflage treatment. Zygomatic anchorage enables distalization in uncooperative or noncompliant patients. We describe 1 such procedure in a 24-year-old woman. We used novel improved superelastic nickel-titanium archwires combined with nickel-titanium open-coil springs to provide a constant and continuous low force to the dentition. We were able to successfully eliminate the protrusive profile and correct the Class II molar relationship using this system of zygomatic anchorage. The posterior occlusal relationships were improved to achieve Class I canine and molar relationships on both sides, and ideal overbite and overjet relationships were established. Facial esthetics was improved with decreased protrusion of the upper and lower lips. The method used here is a promising alternative to traditional distalization techniques and might offer an effective and simple means of distalizing maxillary molars in uncooperative patients. Copyright © 2013 American Association of Orthodontists. Published by Mosby, Inc. All rights reserved.

Dental extrusion with orthodontic miniscrew anchorage: a case report describing a modified method.

Science.gov (United States)

Horliana, Ricardo Fidos; Horliana, Anna Carolina Ratto Tempestini; Wuo, Alexandre do Vale; Perez, Flávio Eduardo Guillin; Abrão, Jorge

2015-01-01

In recent years, the skeletal anchorage through miniscrews has expanded the treatment options in orthodontics (Yamaguchi et al., 2012). We hereby present a modified method for tooth extrusion for cases where crown-lengthening surgery is contraindicated for aesthetic reasons. This modified method uses three orthodontic appliances: a mini-implant, an orthodontic wire, and a bracket. The aim of this case report was to increase the length of the clinical crown of a fractured tooth (tooth 23) by means of an orthodontic extrusion with the modified method of Roth and Diedrich.

Advances in cell culture: anchorage dependence

Science.gov (United States)

Merten, Otto-Wilhelm

2015-01-01

Anchorage-dependent cells are of great interest for various biotechnological applications. (i) They represent a formidable production means of viruses for vaccination purposes at very large scales (in 1000–6000 l reactors) using microcarriers, and in the last decade many more novel viral vaccines have been developed using this production technology. (ii) With the advent of stem cells and their use/potential use in clinics for cell therapy and regenerative medicine purposes, the development of novel culture devices and technologies for adherent cells has accelerated greatly with a view to the large-scale expansion of these cells. Presently, the really scalable systems—microcarrier/microcarrier-clump cultures using stirred-tank reactors—for the expansion of stem cells are still in their infancy. Only laboratory scale reactors of maximally 2.5 l working volume have been evaluated because thorough knowledge and basic understanding of critical issues with respect to cell expansion while retaining pluripotency and differentiation potential, and the impact of the culture environment on stem cell fate, etc., are still lacking and require further studies. This article gives an overview on critical issues common to all cell culture systems for adherent cells as well as specifics for different types of stem cells in view of small- and large-scale cell expansion and production processes. PMID:25533097

Bio-cultural anchorage of the prickly pear cactus in Tlalnepantla (Morelos, Mexico

Directory of Open Access Journals (Sweden)

Torres-Salcido, Gerardo

2016-06-01

Full Text Available The prickly pear cactus is a source of food with strong bio-cultural anchorage in Mexico. This is due to at least three factors: 1 the nature and heritage of cacti; 2 cultural heritage; and 3 the socio-cultural relationships with historical and symbolic roots that have facilitated knowledge of how to cultivate it and how to use it. The aim of this article is to put factors of territorial anchorage and its historical transformation in context by examining the case of the municipality of Tlalnepantla in the state of Morelos, Mexico. This community has experienced accelerated change due to the exchange of traditional crops for the prickly pear cactus and the integration of farming, commercialization and agro-transformation. Our hypothesis is that the market, internal conflicts and a lack of socio-institutional coordination have put social organization into crisis, favoring the territorial spread of the prickly pear cactus and making the Local Agro-Food Systems (LAFS of Tlalnepantla less competitive. The conclusions highlight important economic and social advances whose roots lie in the strengthening and anchorage of the territory-product. However, circumstances both internal and external to the community persist, such as intra-community conflicts, the international market and cultural paradigm shifts that affect the producers and put consolidation of the LAFS at risk.El nopal es un alimento con un fuerte anclaje bio-cultural en México, propiciado por al menos tres factores: 1 la naturaleza y el patrimonio de cactáceas; 2 el patrimonio cultural; y, 3 las relaciones socio-culturales que han permitido un “saber hacer” y un “saber utilizar” con raíces históricas y simbólicas. El objetivo es situar los factores de anclaje territorial y su transformación histórica tomando como caso el municipio de Tlalnepantla, en el estado de Morelos, México. Esta comunidad ha experimentado un acelerado cambio por la reconversión de los cultivos

Prestressed CFRP Strips with Gradient Anchorage for Structural Concrete Retrofitting: Experiments and Numerical Modeling

Directory of Open Access Journals (Sweden)

Julien Michels

2014-01-01

Full Text Available This paper presents a study on the load carrying capacity of reinforced concrete (RC beams strengthened with externally bonded (EB carbon fiber reinforced polymer (CFRP strips prestressed up to 0.6% in strain. At the strip ends, the innovative gradient anchorage is used instead of conventional mechanical fasteners. This method, based on the epoxy resin’s ability to rapidly cure under high temperatures, foresees a sector-wise heating followed by a gradual decrease of the initial prestress force towards the strip ends. The experimental investigation shows a promising structural behavior, resulting in high strip tensile strains, eventually almost reaching tensile failure of the composite strip. Additionally, ductility when considering deflection at steel yielding and at ultimate load is satisfying, too. From a practical point of view, it is demonstrated that premature strip grinding in the anchorage zone is not beneficial. In addition, a non-commercial 1D finite element code has been enlarged to an EB reinforcement with prestressed composite strips. A bilinear bond stress-slip relation obtained in earlier investigations is introduced as an additional failure criterion to the code. The numerical code is able to almost perfectly predict the overall structural behavior. Furthermore, the calculations are used for comparison purposes between an initially unstressed and a prestressed externally bonded composite reinforcement. The increase in cracking and yielding load, as well as differences in structural stiffness are apparent.

Verification of the local structural response of building structures in the anchorage areas of heavy components

International Nuclear Information System (INIS)

Krutzik, N.J.; Tropp, R.

1993-01-01

In both nuclear and non-nuclear areas of power plants, sections of structures, parts of systems and components are attached to walls and floors by means of anchor plates with bolts, anchor sleeves and bolts and through bolts arranged either in groups or individually. In order to simplify the determination of the transfered vibrations induced by external events (e.g. earthquake, aircraft crash), it is normally assumed that the nodal point between component and concrete possesses rigid body characteristics and the building structure (walls, floors) is also inflexible in the anchorage area. In the course of the parametric studies performed, the nonlinear effects on the anchorage area of a component (in this case an anchor plate and concrete slab) were calculated and the effect of these on the actual vibration behavior and the local structural responses of the building structure at the place of installation of heavy components were investigated. The investigations performed reveal that by taking into account the local behaviour in the anchoring point, it is possible to reduce the dynamic response considerably. More detailed examination of the influence of additional parameters (especially of the geometry of the anchor plates and anchor bolts and their material characteristics) will require further investigations aimed at establishing the characteristics of typical anchor plates. (orig.)

Design of steel-liners and their anchorage with regard to non-linear behaviour of liner-material and anchorage

International Nuclear Information System (INIS)

Oberpichler, R.

1979-01-01

The thin steel liner attached by studs or rib-type anchors to the interior wall of a Prestressed Concrete Reactor Pressure Vessel (PCRV) or a Concrete Containment Vessel (PCCV) has to provide the leak-tightness of the vessel. The liner also may serve as internal shuttering for placing concrete as well as a support for the cooling system or thermal isolation. Mainly strained by self-limited loads imposed on the liner by deformations of the vessel-wall or by heatup inside the vessel the liner predominantly will function in a compressive biaxially strained state like a membrane. The vessel-wall is assumed to be a rigid boundary without reactions caused by the liner-anchor-restraints. Furthermore it is assumed that the liner supported in a close-spaced pattern to the concrete with respect to self-limited loads and all effects of non-linear behaviour of liner-material and non-linear anchor-characteristics will not fail by instability, especially not by an effect of snapthrough. Only one essential mode of failure, the shear connector failure is assumed to be basis for all liner investigations. Design of the liner and its anchorage therefore is based on the analysis of large deformations with regard to elastic-plastic behaviour of liner-material and non-linear anchor characteristics. By this method both economical and safe sizing and spacing of the anchors can be calculated. (orig.)

Morphologic and hemodynamic analysis of dental pulp in dogs after molar intrusion with the skeletal anchorage system.

Science.gov (United States)

Konno, Yuichi; Daimaruya, Takayoshi; Iikubo, Masahiro; Kanzaki, Reiko; Takahashi, Ichiro; Sugawara, Junji; Sasano, Takashi

2007-08-01

We have successfully treated skeletal open bite by intruding posterior teeth with the skeletal anchorage system. Our aim in this study was to morphologically and hemodynamically evaluate the changes in pulp tissues when molars are radically intruded. The mandibular fourth premolars of 9 adult beagle dogs were divided into 3 groups: a sham operated group (n = 6, 3 dogs), 4-month intrusion group (n = 6, 3 dogs), and a further 4-month retention group (n = 6, 3 dogs). We evaluated the morphological changes of the pulp and dentin-the amount of vacuolar degeneration in the odontoblast layer, the predentin width and nervous continuity in the pulp tissue, and the pulpal blood-flow response evoked by electrical stimulation in the dental pulp. Extreme molar intrusion with the skeletal anchorage system caused slight degenerative changes in the pulp tissue, followed by recovery after the orthodontic force was released. Circulatory system and nervous functions were basically maintained during the intrusion, although a certain level of downregulation was observed. These morphologic and functional regressive changes in the pulp tissue after molar intrusion improved during the retention period. Histologic changes and changes in pulpal blood flow and function are reversible, even during radical intrusion of molars.

Elevated p21-Activated Kinase 2 Activity Results in Anchorage-Independent Growth and Resistance to Anticancer Drug–Induced Cell Death

Directory of Open Access Journals (Sweden)

Jerry W. Marlin

2009-03-01

Full Text Available p21-Activated kinase 2 (PAK-2 seems to be a regulatory switch between cell survival and cell death signaling. We have shown previously that activation of full-length PAK-2 by Rac or Cdc42 stimulates cell survival, whereas caspase activation of PAK-2 to the proapoptotic PAK-2p34 fragment is involved in the cell death response. In this study, we present a role of elevated activity of full-length PAK-2 in anchorage-independent growth and resistance to anticancer drug–induced apoptosis of cancer cells. Hs578T human breast cancer cells that have low levels of PAK-2 activity were more sensitive to anticancer drug–induced apoptosis and showed higher levels of caspase activation of PAK-2 than MDA-MB435 and MCF-7 human breast cancer cells that have high levels of PAK-2 activity. To examine the role of elevated PAK-2 activity in breast cancer, we have introduced a conditionally active PAK-2 into Hs578T human breast cells. Conditional activation of PAK-2 causes loss of contact inhibition and anchorage-independent growth of Hs578T cells. Furthermore, conditional activation of PAK-2 suppresses activation of caspase 3, caspase activation of PAK-2, and apoptosis of Hs578T cells in response to the anticancer drug cisplatin. Our data suggest a novel mechanism by which full-length PAK-2 activity controls the apoptotic response by regulating levels of activated caspase 3 and thereby its own cleavage to the proapoptotic PAK-2p34 fragment. As a result, elevated PAK-2 activity interrupts the apoptotic response and thereby causes anchorage-independent survival and growth and resistance to anticancer drug–induced apoptosis.

Bst1 is required for Candida albicans infecting host via facilitating cell wall anchorage of Glycosylphosphatidyl inositol anchored proteins

Science.gov (United States)

Liu, Wei; Zou, Zui; Huang, Xin; Shen, Hui; He, Li Juan; Chen, Si Min; Li, Li Ping; Yan, Lan; Zhang, Shi Qun; Zhang, Jun Dong; Xu, Zheng; Xu, Guo Tong; An, Mao Mao; Jiang, Yuan Ying

2016-01-01

Glycosylphosphatidyl inositol anchored proteins (GPI-APs) on fungal cell wall are essential for invasive infections. While the function of inositol deacylation of GPI-APs in mammalian cells has been previously characterized the impact of inositol deacylation in fungi and implications to host infection remains largely unexplored. Herein we describe our identification of BST1, an inositol deacylase of GPI-Aps in Candida albicans, was critical for GPI-APs cell wall attachment and host infection. BST1-deficient C. albicans (bst1Δ/Δ) was associated with severely impaired cell wall anchorage of GPI-APs and subsequen unmasked β-(1,3)-glucan. Consistent with the aberrant cell wall structures, bst1Δ/Δ strain did not display an invasive ability and could be recognized more efficiently by host immune systems. Moreover, BST1 null mutants or those expressing Bst1 variants did not display inositol deacylation activity and exhibited severely attenuated virulence and reduced organic colonization in a murine systemic candidiasis model. Thus, Bst1 can facilitate cell wall anchorage of GPI-APs in C. albicans by inositol deacylation, and is critical for host invasion and immune escape. PMID:27708385

A comparison of lower canine retraction and loss of anchorage between conventional and self-ligating brackets: a single-center randomized split-mouth controlled trial.

Science.gov (United States)

da Costa Monini, André; Júnior, Luiz Gonzaga Gandini; Vianna, Alexandre Protásio; Martins, Renato Parsekian

2017-05-01

To evaluate the rate of lower canine retraction, anchorage loss, and changes on lower canines and first molars axial inclination using self-ligating and conventional brackets. Twenty-five adult patients with a treatment plan involving extractions of four first premolars were selected for this split-mouth trial and had either conventional or self-ligating brackets bonded to lower canines in a block randomization. Retraction was accomplished using 100-g nickel titanium closed-coil springs, which were reactivated each 4 weeks. Oblique radiographs were taken before and after total canine retraction and the cephalograms were superimposed on stable structures of the mandible. Cephalometric points were digitized twice by a single-blinded operator for error control and the average of the points were used to determine the following variables: canine cusp horizontal changes, molar cusp horizontal changes, and angulation changes in canines and molars. Paired t tests were used to analyze the blinded data for group differences. All patients reached final phase without bracket debonds. No differences were found between the two groups for all variables tested. No serious harm was observed. Both brackets showed the same rate of canine retraction and loss of anteroposterior anchorage of the molars. No changes were found between brackets regarding the inclination of canines and first molars. Using self-ligating brackets to retract lower canines will not increase the velocity of tooth movement, does not increase anchorage, and does not decrease tipping.

Transverse maxillary distraction in patients with periodontal pathology or insufficient tooth anchorage using custom-made devices.

Science.gov (United States)

Fernández-Sanromán, Jacinto; Donascimento, Montserrat González; López, Alberto Costas; Ferro, Martín Fernández; Berrondo, Ibon Almandoz

2010-07-01

We present our experience using modified Hyrax devices for treating transverse deficiencies of the maxilla in adult patients with periodontal pathology or insufficient tooth anchorage. The surgical technique, clinical indications, and results are discussed. Eight adult patients (6 females, 2 males) requiring maxillary expansion were studied prospectively between July 2002 and July 2007. All the patients had periodontal pathology or insufficient tooth anchorage preventing the use of conventional Hyrax devices. Patients underwent surgically assisted rapid maxillary expansion with the use of custom-made modified Hyrax devices (bone-borne or tooth-bone-borne devices). Patients received preoperatively (T1), at the end of distraction (T2), at removal of the expansion device (T3), and 12 months after surgery (T4) lateral and posterior anterior cephalograms and study models to measure the width of the anterior and posterior dental arches with a digital sliding calliper. Mean age was 28.5 years (range, 18-45 years). A significant widening of the anterior (6.3 +/- 1.6 mm) and posterior (7.1 +/- 1.2 mm) dental arches was demonstrated. No significant differences were found when comparing T3 with T4 measures. No significant complications were found. The results indicated that maxillary expansion with custom-made devices in adults was an easy, affordable, predictable and stable technique without significant complications in patients who suffer periodontal pathology or patients without enough dental support. Copyright 2010 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.

British Orthodontic Society national audit of temporary anchorage devices (TADs): report of the first thousand TADs placed.

Science.gov (United States)

Bearn, David R; Alharbi, Fahad

2015-09-01

To provide data from the British Orthodontic Society (BOS) national clinical audit on temporary anchorage device (TAD) use following the recommendations of the National Institute for Health and Clinical Excellence (NIHCE) Design and setting: The Audit commenced on 1 January 2008 and is still ongoing. This article reports the data for TADs placed from 1 January 2008 to 1 November 2013. Audit data was collected from participants using a system of both on-line data entry and hard copy forms. The criteria and standards for the audit were set following the NIHCE report in conjunction with the Development and Standards Committee of the BOS. Virtually all participants used the on-line data entry available on the BOS website. The data submitted was checked and entered manually into an Excel spreadsheet, and transferred to SPSS for analysis. Written information and documented discussion of risks were provided in over 90% of TADs placed, but 17.4% were placed without a specific signed consent form. Temporary anchorage device failure rate was 24.2% overall. Among failed TADs, 93.1% were lost or removed due to excess mobility. Infection or inflammation resulting in loss or removal was reported in 6% of TADs. The only audit standard that was met was failures due to infection of inflammation. The rest of the audit standards were not met. Recommendations are made to address these issues.

Spheroid Culture of Head and Neck Cancer Cells Reveals an Important Role of EGFR Signalling in Anchorage Independent Survival.

Science.gov (United States)

Braunholz, Diana; Saki, Mohammad; Niehr, Franziska; Öztürk, Merve; Borràs Puértolas, Berta; Konschak, Robert; Budach, Volker; Tinhofer, Ingeborg

2016-01-01

In solid tumours millions of cells are shed into the blood circulation each day. Only a subset of these circulating tumour cells (CTCs) survive, many of them presumable because of their potential to form multi-cellular clusters also named spheroids. Tumour cells within these spheroids are protected from anoikis, which allows them to metastasize to distant organs or re-seed at the primary site. We used spheroid cultures of head and neck squamous cell carcinoma (HNSCC) cell lines as a model for such CTC clusters for determining the role of the epidermal growth factor receptor (EGFR) in cluster formation ability and cell survival after detachment from the extra-cellular matrix. The HNSCC cell lines FaDu, SCC-9 and UT-SCC-9 (UT-SCC-9P) as well as its cetuximab (CTX)-resistant sub-clone (UT-SCC-9R) were forced to grow in an anchorage-independent manner by coating culture dishes with the anti-adhesive polymer poly-2-hydroxyethylmethacrylate (poly-HEMA). The extent of apoptosis, clonogenic survival and EGFR signalling under such culture conditions was evaluated. The potential of spheroid formation in suspension culture was found to be positively correlated with the proliferation rate of HNSCC cell lines as well as their basal EGFR expression levels. CTX and gefitinib blocked, whereas the addition of EGFR ligands promoted anchorage-independent cell survival and spheroid formation. Increased spheroid formation and growth were associated with persistent activation of EGFR and its downstream signalling component (MAPK/ERK). Importantly, HNSCC cells derived from spheroid cultures retained their clonogenic potential in the absence of cell-matrix contact. Addition of CTX under these conditions strongly inhibited colony formation in CTX-sensitive cell lines but not their resistant subclones. Altogether, EGFR activation was identified as crucial factor for anchorage-independent survival of HNSCC cells. Targeting EGFR in CTC cluster formation might represent an attractive anti

Remains of the ancient ports and anchorage points at Miyani and Visawada, on the west coast of India: A study based on underwater investigations

Digital Repository Service at National Institute of Oceanography (India)

Gaur, A.S.; Sundaresh; Tripati, S.

as an excellent natural harbour. The important antiquities include varieties of stone anchors, which are very similar to those reported from Dwarka and Bet Dwarka. The identification of ancient anchorage points between water depth of 5 and 15 m is another...

A comparitive clinical study between self tapping and drill free screws as a source of rigid orthodontic anchorage.

Science.gov (United States)

Gupta, Nishant; Kotrashetti, S M; Naik, Vijay

2012-03-01

Self-tapping miniscrews are commonly being used as a temporary anchorage device for orthodontic purpose. A prerequisite for the insertion of these screws is the preparation of a pilot hole, which is time consuming and may result in damage to nerves, tooth root, drill bit breakage and thermal necrosis of bone. On the other hand the design of drill-free screws enables them to be inserted without drilling. The aim of this prospective study was to compare the stability and clinical response of the soft tissue around the self tapping and drill free screws when used for orthodontic anchorage for en mass retraction of maxillary anterior teeth. The study sample consisted of 20 patients requiring retraction of maxillary anterior teeth. The screws were placed in the alveolar bone between maxillary 2nd premolar and 1st molar bilaterally at the junction of attached gingiva and moveable mucosa. Pilot hole was drilled on the side which was selected for insertion of the self tapping screw under copious irrigation, after which it was inserted. Drill free screw was inserted on the contralateral side without predrilling. All screws were immediately loaded with 150-200 gm of retraction force. Patients were recalled for regular follow up for a period of 6 months. If the screws became mobile or showed any signs of inflammation during the course of the study, they were considered to be a failure. After a period of 6 months an overall success rate of 77.5% was noted. Four self tapping and five drill-free screws failed during the study. There was no statistically significant difference between the two types of screws with respect to success/failure. Mobility was found to be the major cause for the failure. Both self-tapping and the drill-free screws are effective anchorage units. But the latter have an edge over the conventional self-tapping screws because of decrease in operative time, little bone debris, less thermal damage, lower morbidity, and minimal patient discomfort as

Success rates and factors associated with failure of temporary anchorage devices: A prospective clinical trial.

Science.gov (United States)

Aly, Shehab A; Alyan, Doha; Fayed, Mona S; Alhammadi, Maged S; Mostafa, Yehya A

2018-03-06

The objective of the present study was to investigate success rates and associated factors affecting temporary anchorage device (TAD) failure in different biomechanical applications. A total of 180 TADs were used as a part of 82 patients' treatment plan (24 males and 58 females); their mean age was 21.41 years. Three types of TADs were used: 50 (3M ESPE, Neuss, Germany), 56 (Bone screw; Jeil Medical, Seoul, Korea), and 74 (Morelli, Sorocaba, Brazil). Eight maxillary and four mandibular sites were selected for insertion. Three different lengths (6, 8, and 10 mm) and three different diameters (1.5, 1.6, and 1.8 mm) were used. The force levels were set at 50, 100, 150, 200, and 250 g. Patient-, implant-, and operator-dependent factors were evaluated throughout the 266 days of function. Qualitative variables were described by proportions and percentages and analyzed using χ 2 test. The overall success rate was 82.2%. The higher age group showed a significantly higher success rate. Oral hygiene showed a statistically-significant (P ˂ .05) difference between both success and failure groups. All other patient-related factors showed no significant differences. Regarding force levels used, the highest success rate was in 250 g and the lowest was in 100 g. There were no significant differences between both groups regarding other implant- and operator-related factors. Temporary anchorage devices have a good success rate and are beneficial to be integrated in orthodontic treatment planning. Patient age, oral hygiene, and force level are the most significant factors affecting TAD success. © 2018 John Wiley & Sons Australia, Ltd.

Early bone anchorage to micro- and nano-topographically complex implant surfaces in hyperglycemia.

Science.gov (United States)

Ajami, Elnaz; Bell, Spencer; Liddell, Robert S; Davies, John E

2016-07-15

The aim of this work was to investigate the effect of implant surface design on early bone anchorage in the presence of hyperglycemia. 108 Wistar rats were separated into euglycemic (EG) controls and STZ-treated hyperglycemic (HG) groups, and received bilateral femoral custom rectangular implants of two surface topographies: grit blasted (GB) and grit-blast with a superimposed calcium phosphate nanotopography (GB-DCD). The peri-implant bone was subjected to a tensile disruption test 5, 7, and 9days post-operatively (n=28/time point); the force was measured; and the residual peri-implant bone was observed by scanning electron microscopy (SEM). Disruption forces at 5days were not significantly different from zero for the GB implants (p=0.24) in either metabolic group; but were for GB+DCD implants in both metabolic groups (pmicro-surfaced implants showed significantly different disruption forces at all time points (e.g. >15N and implants, as all values were very low (implant bone showed compromised intra-fibrillar collagen mineralization in hyperglycemia, while inter-fibrillar and cement line mineralization remained unaffected. Enhanced bone anchorage to the implant surfaces was observed on the nanotopographically complex surface independent of metabolic group. The compromised intra-fibrillar mineralization observed provides a mechanism by which early bone mineralization is affected in hyperglycemia. It is generally accepted that the hyperglycemia associated with diabetes mellitus compromises bone quality, although the mechanism by which this occurs is unknown. Uncontrolled hyperglycemia is therefore a contra-indication for bone implant placement. It is also known that nano-topographically complex implant surfaces accelerate early peri-implant healing. In this report we show that, in our experimental model, nano-topographically complex surfaces can mitigate the compromised bone healing seen in hyperglycemia. Importantly, we also provide a mechanistic explanation for

[The application of Edgewise technique auxillary with extra oral anchorage and class III elastic in the treatment of bimaxillary protrusion.].

Science.gov (United States)

Liu, H H; Weng, S E; Chen, R J

1995-12-01

In the treatment of growing bimaxillary protrusion patients,Edgewise technique auxillary with extra oral anchorage and class III elastic help to improve the patient's chin shape,recover his beauty of lower facial part and get a good occlusion along with the growing of mandible.The purpose of this study is:analysis the force system in the treatment and evaluate the result of the treatment with some typical cases.

Anchorage of TiO2-blasted, HA-coated, and machined implants: an experimental study with rabbits

DEFF Research Database (Denmark)

Gotfredsen, K; Wennerberg, A; Johansson, C

1995-01-01

The purpose of this study was to evaluate the histometrical and biomechanical anchorage of TiO2-blasted implants and TiO2-blasted implants coated with hydroxyapatite. The control implants were machined. Twenty-six rabbits had a total of 156 implants placed in the proximal part of the tibia. Each...... rabbit had a machined, a TiO2-blasted, and a TiO2-blasted, HA-coated implant placed in each tibia. After a healing period of 3 and 12 weeks, respectively, the implants placed in the right tibia were used for removal torque test, and the implants placed in the left tibia were used for histomorphometrical...

Association of ultraviolet-induced retrovirus expression with anchorage-independent survival in rat embryo cells

International Nuclear Information System (INIS)

Suk, W.A.

1985-01-01

The authors have shown in the AI assay that the nontransforming retrovirus increases the differential in enhanced survival response in infected cultures. To more fully understand this aspect of the system, they examined the effect of UV irradiation on infected and uninfected FRE cells. In this communication the authors report that UV irradiation induces AI survival in infected and uninfected cells;in uninfected cells there is a concomitant induction of endogenous retrovirus expression. The AI survival of both cell lines was determined using a previously described procedure. Anchorage-dependent media control and solvent control cells, when suspended in medium above an agar base layer, showed a rapid decline in cell survival;however, cells that had been treated with carcinogen did not undergo the destructive process that took place in control cells, indicating specificity

Orthodontic retreatment using anchorage with miniplate to camouflage a Class III skeletal pattern.

Science.gov (United States)

Farret, Marcel Marchiori

2016-06-01

This manuscript describes the treatment of a 27-year-old patient who was previously treated with two maxillary first premolar extractions. The patient had skeletal Class III malocclusion, Class III canine relationship, anterior crossbite, and a concave profile. As the patient refused orthognathic surgery, a miniplate was used on the right side of the lower arch as an anchorage unit after the extraction of mandibular first premolars, aiding the retraction of anterior teeth. At the end of treatment, anterior crossbite was corrected, in which first molars and canines were in a Class I relationship, and an excellent intercuspation was reached. Furthermore, patient's profile remarkably improved as a result of mandibular incisor retraction. A 30-month follow-up showed good stability of the results obtained. This case was presented to the Brazilian Board of Orthodontics and Dentofacial Orthopedics (BBO) as one of the requirements to become diplomate by the BBO.

Characterization of the aspects of osteoprogenitor cell interactions with physical tetracalcium phosphate anchorage on titanium implant surfaces

Energy Technology Data Exchange (ETDEWEB)

Ko, Chia-Ling [Advanced Medical Devices and Composites Laboratory, Department of Fiber and Composite Materials, Feng Chia University, Taichung 40724, Taiwan (China); Dental Medical Devices and Materials Research Center, College of Dental Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan (China); Chang, Ya-Yuan; Liou, Cian-Hua [Alliance Global Technology Co., Ltd., Kaohsiung Medical Device Special Zone in Southern Taiwan Science Park, Kaohsiung 82151, Taiwan (China); Chen, Wen-Cheng, E-mail: wencchen@fcu.edu.tw [Advanced Medical Devices and Composites Laboratory, Department of Fiber and Composite Materials, Feng Chia University, Taichung 40724, Taiwan (China)

2015-04-01

Well-designed implants are used not only to modify the geometry of the implant but also to change the chemical properties of its surfaces. The present study aims to assess the biofunctional effects of tetracalcium phosphate (TTCP) particles as a physical anchor on the implant surface derived through sandblasting. The characteristics of the surface, cell viability, and alkaline phosphatase (ALP) activity toward osteoprogenitor cells (D1) were obtained. D1 cells were cultured on a plain surface that underwent sandblasting and acid etching (SLA) (control SLA group) and on different SLA surfaces with different anchoring TTCP rates (new test groups, M and H). The mean anchoring rates were 57% (M) and 74% (H), and the anchored thickness was estimated to range from 12.6 μm to 18.3 μm. Compared with the control SLA surface on Ti substrate, the new test groups with different TTCP anchoring rates (M and H) failed to improve cell proliferation significantly but had a well-differentiated D1 cell phenotype that enhanced ALP expression in the early stage of cell cultures, specifically, at day 7. Results suggest that the SLA surface with anchored TTCP can accelerate progenitor bone cell mineralization. This study shows the potential clinical application of the constructed geometry in TTCP anchorage on Ti for dental implant surface modification. - Highlights: • TTCP (tetracalcium phosphate) as a physical anchorage on implant is characterized. • Theoretical values of anchored thickness and capping areas were estimated. • TTCP anchored by sandblasting can accelerate progenitor bone cell mineralization. • TTCP anchored on SLA (sandblasting and acid etching) surface is a promising method.

Characterization of the aspects of osteoprogenitor cell interactions with physical tetracalcium phosphate anchorage on titanium implant surfaces

International Nuclear Information System (INIS)

Ko, Chia-Ling; Chang, Ya-Yuan; Liou, Cian-Hua; Chen, Wen-Cheng

2015-01-01

Well-designed implants are used not only to modify the geometry of the implant but also to change the chemical properties of its surfaces. The present study aims to assess the biofunctional effects of tetracalcium phosphate (TTCP) particles as a physical anchor on the implant surface derived through sandblasting. The characteristics of the surface, cell viability, and alkaline phosphatase (ALP) activity toward osteoprogenitor cells (D1) were obtained. D1 cells were cultured on a plain surface that underwent sandblasting and acid etching (SLA) (control SLA group) and on different SLA surfaces with different anchoring TTCP rates (new test groups, M and H). The mean anchoring rates were 57% (M) and 74% (H), and the anchored thickness was estimated to range from 12.6 μm to 18.3 μm. Compared with the control SLA surface on Ti substrate, the new test groups with different TTCP anchoring rates (M and H) failed to improve cell proliferation significantly but had a well-differentiated D1 cell phenotype that enhanced ALP expression in the early stage of cell cultures, specifically, at day 7. Results suggest that the SLA surface with anchored TTCP can accelerate progenitor bone cell mineralization. This study shows the potential clinical application of the constructed geometry in TTCP anchorage on Ti for dental implant surface modification. - Highlights: • TTCP (tetracalcium phosphate) as a physical anchorage on implant is characterized. • Theoretical values of anchored thickness and capping areas were estimated. • TTCP anchored by sandblasting can accelerate progenitor bone cell mineralization. • TTCP anchored on SLA (sandblasting and acid etching) surface is a promising method

Assessing the Frequency and Material Consequences of Collisions with Vessels Lying at an Anchorage in Line with IALA iWrap MkII

Directory of Open Access Journals (Sweden)

Hans-Christoph Burmeister

2014-03-01

Full Text Available This paper proposes a collision model for ships underway and temporary objects as an extension to state-of-the-art maritime risk assessment like IALA iWrap MkII. It gives a brief review of frequency modeling's and consequence calculation theory as well as its applications, before it analogously derives a model to assess the risk of anchorage areas. Subsequently, its benefit is demonstrated by an example scenario.

Isolated scaphotrapeziotrapezoid osteoarthritis treatment using resurfacing arthroplasty with scaphoid anchorage.

Science.gov (United States)

Humada Álvarez, G; Simón Pérez, C; García Medrano, B; Faour Martín, O; Marcos Rodríguez, J J; Vega Castrillo, A; Martín Ferrero, M A

The aim of this study is to show the results of scaphotrapeziotrapezoid (STT) joint osteoarthritis treatment performing resurfacing arthroplasty with scaphoid anchorage. An observational, descriptive and retrospective study was performed. Ten patients with isolated STT joint osteoarthritis were studied between 2013 and 2015. The mean follow-up time was 26months. Clinical results, functional and subjective scores were reviewed. The patients were satisfied, achieving an average of 2.1 (0-3) on the VAS score and 16 (2 to 28) in the DASH questionnaire, and returning to work in the first three months post-surgery. Recovery of range of motion compared to the contralateral wrist was 96% in extension, 95% in flexion, 87% in ulnar deviation and 91% in radial deviation. The average handgrip strength of the wrist was 95% and pinch strength was 95% compared to the contralateral side. There were no intraoperative complications or alterations in postoperative carpal alignment. Resurfacing arthroplasty is proposed as a good and novel alternative in treating isolated SST joint arthritis. Achieving the correct balance between the strength and mobility of the wrist, without causing carpal destabilisation, is important to obtain satisfactory clinical and functional results. Copyright © 2017. Publicado por Elsevier España, S.L.U.

Study on reinforced concrete high-rise building using prefabricated beam-column joints. Part 3. ; Basic anchorage behaviors of longitudinal bars of beams. Hahsirater dot hari setsugobu PC ka koho (PG connection koho) wo mochiita RC koso tatemono no kaihatsu. 3. ; Hari shukin no kisoteki teichaku seijo

Energy Technology Data Exchange (ETDEWEB)

SEkine, M.; Yoshioka, K.; Eto, H. (Obayashi Corp., Tokyo (Japan))

1991-08-10

Pull-out tests were carried out to examine basic anchorage behaviors of through holes for beam re-bars by using a PG connection method, in which columns and beam-column joints with through holes for beam re-bars in the reinforced concrete framed construction are precast simultaneously. Specimens made by the PG connection method showed better anchorage behaviors than specimens made by the conventional anchorage method. In case of anchorage width of 80cm and concrete strength of about 350kgf/cm{sup 2}, it was recognized that large slipping of re-bars did not occur under allowable bond stress when the interval between re-bars was not less than 15cm and covering depth to the core of re-bars was not less than 8cm. Concerning a specimen which did not show splitting bond failure because of lateral compressive stress, bond stress of re-bars when large slipping occurred was 1.5 times or more in comparison with the allowable bond stress. Since this specimen held high slipping rigidity even after increase of slipping, its anchoring stress increased by 32-57% compared with a specimen without lateral compressive stress. 4 refs., 7 figs., 3 tabs.

Orthodontic retreatment using anchorage with miniplate to camouflage a Class III skeletal pattern

Directory of Open Access Journals (Sweden)

Marcel Marchiori Farret

Full Text Available ABSTRACT This manuscript describes the treatment of a 27-year-old patient who was previously treated with two maxillary first premolar extractions. The patient had skeletal Class III malocclusion, Class III canine relationship, anterior crossbite, and a concave profile. As the patient refused orthognathic surgery, a miniplate was used on the right side of the lower arch as an anchorage unit after the extraction of mandibular first premolars, aiding the retraction of anterior teeth. At the end of treatment, anterior crossbite was corrected, in which first molars and canines were in a Class I relationship, and an excellent intercuspation was reached. Furthermore, patient's profile remarkably improved as a result of mandibular incisor retraction. A 30-month follow-up showed good stability of the results obtained. This case was presented to the Brazilian Board of Orthodontics and Dentofacial Orthopedics (BBO as one of the requirements to become diplomate by the BBO.

Characterization of mutagen-activated cellular oncogenes that confer anchorage independence to human fibroblasts and tumorigenicity to NIH 3T3 cells: Sequence analysis of an enzymatically amplified mutant HRAS allele

International Nuclear Information System (INIS)

Stevens, C.W.; Manoharan, T.H.; Fahl, W.E.

1988-01-01

Treatment of diploid human fibroblasts with an alkylating mutagen has been shown to induce stable, anchorage-independent cell populations at frequencies consistent with an activating mutation. After treatment of human foreskin fibroblasts with the mutagen benzo[α]pyrene (±)anti-7,8-dihydrodiol 9,10-epoxide and selection in soft agar, 17 anchorage-independent clones were isolated and expanded, and their cellular DNA was used to cotransfect NIH 3T3 cells along with pSV2neo. DNA from 11 of the 17 clones induced multiple NIH 3T3 cell tumors in recipient nude mice. Southern blot analyses showed the presence of human Alu repetitive sequences in all of the NIH 3T3 tumor cell DNAs. Intact, human HRAS sequences were observed in 2 of the 11 tumor groups, whereas no hybridization was detected when human KRAS or NRAS probes were used. Slow-migrating ras p21 proteins, consistent with codon 12 mutations, were observed in the same two NIH 3T3 tumor cell groups that contained the human HRAS bands. Genomic DNA from one of these two human anchorage-independent cell populations (clone 21A) was used to enzymatically amplify a portion of exon 1 of the HRAS gene. The results demonstrate that exposure of normal human cells to a common environmental mutagen yields HRAS GC → TA codon 12 transversions that have been commonly observed in human tumors

En-masse retraction with a preformed nickel-titanium and stainless steel archwire assembly and temporary skeletal anchorage devices without posterior bonding.

Science.gov (United States)

Jee, Jeong-Hyun; Ahn, Hyo-Won; Seo, Kyung-Won; Kim, Seong-Hun; Kook, Yoon-Ah; Chung, Kyu-Rhim; Nelson, Gerald

2014-09-01

To evaluate the therapeutic effects of a preformed assembly of nickel-titanium (NiTi) and stainless steel (SS) archwires (preformed C-wire) combined with temporary skeletal anchorage devices (TSADs) as the sole source of anchorage and to compare these effects with those of a SS version of C-wire (conventional C-wire) for en-masse retraction. Thirty-one adult female patients with skeletal Class I or II dentoalveolar protrusion, mild-to-moderate anterior crowding (3.0-6.0 mm), and stable Class I posterior occlusion were divided into conventional (n = 15) and preformed (n = 16) C-wire groups. All subjects underwent first premolar extractions and en-masse retraction with pre-adjusted edgewise anterior brackets, the assigned C-wire, and maxillary C-tubes or C-implants; bonded mesh-tube appliances were used in the mandibular dentition. Differences in pretreatment and post-retraction measurements of skeletal, dental, and soft-tissue cephalometric variables were statistically analyzed. Both groups showed full retraction of the maxillary anterior teeth by controlled tipping and space closure without altered posterior occlusion. However, the preformed C-wire group had a shorter retraction period (by 3.2 months). Furthermore, the maxillary molars in this group showed no significant mesialization, mesial tipping, or extrusion; some mesialization and mesial tipping occurred in the conventional C-wire group. Preformed C-wires combined with maxillary TSADs enable simultaneous leveling and space closure from the beginning of the treatment without maxillary posterior bonding. This allows for faster treatment of dentoalveolar protrusion without unwanted side effects, when compared with conventional C-wire, evidencing its clinical expediency.

Anchorage onto deciduous teeth: effectiveness of early rapid maxillary expansion in increasing dental arch dimension and improving anterior crowding.

Science.gov (United States)

Mutinelli, Sabrina; Manfredi, Mario; Guiducci, Antonio; Denotti, Gloria; Cozzani, Mauro

2015-01-01

Anchorage onto permanent dentition is a common procedure in rapid maxillary expansion. However, replacing first permanent molars with the second deciduous molars seems to be an option to reduce some negative side effects during orthodontic treatment. The purpose of this study was to evaluate the dental effect of rapid maxillary expansion with anchorage exclusively onto deciduous teeth performed in the first period of transition. Twenty patients with a lateral cross-bite treated exclusively by a Haas expander in early mixed dentition were retrospectively analyzed before treatment, at appliance removal, and at 21 months out of retention. The sagittal and transverse dimensions, together with the inter-canine arch and irregularity index, were digitally measured on scanned images of dental casts. The patients were compared with three balanced control groups (in total, 60 individuals) matched for gender. Two control groups had the same canine dental class as the treated group at T1, were in the inter-transitional period, and either had or lacked a lateral cross-bite. The last control group was comprised of adolescents in permanent dentition with a dental class I. The statistical analysis was performed by means of repeated-measures ANOVA for paired data and one-way ANOVA, the Kruskal-Wallis test, and the Mann-Whitney test for independent measures (α-level p dentition), the dental arch dimensions of treated patients were similar to those of adolescents with a dental class I and significantly wider than those of patients with a lateral cross-bite. Also, the anterior irregularity index was lower among patients who had undergone expansion treatments than in all untreated study participants. The Haas expander anchored to the deciduous teeth is effective in increasing the dental arch width in patients with a lateral cross-bite. The dimensions of the dental arch were modified earlier toward the values of the permanent dentition.

Pedicle screw anchorage of carbon fiber-reinforced PEEK screws under cyclic loading.

Science.gov (United States)

Lindtner, Richard A; Schmid, Rene; Nydegger, Thomas; Konschake, Marko; Schmoelz, Werner

2018-03-01

Pedicle screw loosening is a common and significant complication after posterior spinal instrumentation, particularly in osteoporosis. Radiolucent carbon fiber-reinforced polyetheretherketone (CF/PEEK) pedicle screws have been developed recently to overcome drawbacks of conventional metallic screws, such as metal-induced imaging artifacts and interference with postoperative radiotherapy. Beyond radiolucency, CF/PEEK may also be advantageous over standard titanium in terms of pedicle screw loosening due to its unique material properties. However, screw anchorage and loosening of CF/PEEK pedicle screws have not been evaluated yet. The aim of this biomechanical study therefore was to evaluate whether the use of this alternative nonmetallic pedicle screw material affects screw loosening. The hypotheses tested were that (1) nonmetallic CF/PEEK pedicle screws resist an equal or higher number of load cycles until loosening than standard titanium screws and that (2) PMMA cement augmentation further increases the number of load cycles until loosening of CF/PEEK screws. In the first part of the study, left and right pedicles of ten cadaveric lumbar vertebrae (BMD 70.8 mg/cm 3  ± 14.5) were randomly instrumented with either CF/PEEK or standard titanium pedicle screws. In the second part, left and right pedicles of ten vertebrae (BMD 56.3 mg/cm 3  ± 15.8) were randomly instrumented with either PMMA-augmented or nonaugmented CF/PEEK pedicle screws. Each pedicle screw was subjected to cyclic cranio-caudal loading (initial load ranging from - 50 N to + 50 N) with stepwise increasing compressive loads (5 N every 100 cycles) until loosening or a maximum of 10,000 cycles. Angular screw motion ("screw toggling") within the vertebra was measured with a 3D motion analysis system every 100 cycles and by stress fluoroscopy every 500 cycles. The nonmetallic CF/PEEK pedicle screws resisted a similar number of load cycles until loosening as the contralateral standard

En-masse retraction with a preformed nickel-titanium and stainless steel archwire assembly and temporary skeletal anchorage devices without posterior bonding

Science.gov (United States)

Jee, Jeong-Hyun; Ahn, Hyo-Won; Seo, Kyung-Won; Kook, Yoon-Ah; Chung, Kyu-Rhim; Nelson, Gerald

2014-01-01

Objective To evaluate the therapeutic effects of a preformed assembly of nickel-titanium (NiTi) and stainless steel (SS) archwires (preformed C-wire) combined with temporary skeletal anchorage devices (TSADs) as the sole source of anchorage and to compare these effects with those of a SS version of C-wire (conventional C-wire) for en-masse retraction. Methods Thirty-one adult female patients with skeletal Class I or II dentoalveolar protrusion, mild-to-moderate anterior crowding (3.0-6.0 mm), and stable Class I posterior occlusion were divided into conventional (n = 15) and preformed (n = 16) C-wire groups. All subjects underwent first premolar extractions and en-masse retraction with pre-adjusted edgewise anterior brackets, the assigned C-wire, and maxillary C-tubes or C-implants; bonded mesh-tube appliances were used in the mandibular dentition. Differences in pretreatment and post-retraction measurements of skeletal, dental, and soft-tissue cephalometric variables were statistically analyzed. Results Both groups showed full retraction of the maxillary anterior teeth by controlled tipping and space closure without altered posterior occlusion. However, the preformed C-wire group had a shorter retraction period (by 3.2 months). Furthermore, the maxillary molars in this group showed no significant mesialization, mesial tipping, or extrusion; some mesialization and mesial tipping occurred in the conventional C-wire group. Conclusions Preformed C-wires combined with maxillary TSADs enable simultaneous leveling and space closure from the beginning of the treatment without maxillary posterior bonding. This allows for faster treatment of dentoalveolar protrusion without unwanted side effects, when compared with conventional C-wire, evidencing its clinical expediency. PMID:25309863

DIRECT USAGE OF MINISCREW ANCHORAGE TO INTRUDE OVERERUPTED MAXILLARY POSTERIOR TEETH BEFORE PROSTHODONTIC PREPARATION:A CASE REPORT

Directory of Open Access Journals (Sweden)

Yasemin Bahar Acar

2016-01-01

Full Text Available Overeruption of maxillary molars due loss of opposing teeth creates occlusal and functional interferences. Before reconstruction can be initiated, intrusion of overerupted molars becomes essential. This report illustrates treatment of overerupted maxillary premolar and molar via direct use of miniscrew anchorage. A 24-year old female had lost first and second left mandibular molars due to pulpal necrotizing agents, resulting with a large alveolar bone defect and overerupted maxillary premolar and molar. She had a history of unsuccessful alveolar distraction of mandibular left premolars to increase the alveolar bone height prior to implant placement. Patient was satisfied with her smile and refused comprehensive orthodontic treatment. Maxillary premolar and molar were intruded segmentally for 4mm in 8 months, using a combination of a mini-implant and partialfixed edgewise appliances. Biological responses of teeth and surrounding bony structures to intrusion appeared normal and acceptable in radiographic and clinical examination.

[Three dimensional finite element analysis of maxillary anterior teeth retraction with micro-implant anchorage and sliding mechanics].

Science.gov (United States)

Zhang, Yi; Zhang, Lei; Fan, Yu-bo; Song, Jin-lin; Deng, Feng

2009-10-01

To investigate the biomechanical effects of micro-implant anchorage technique with sliding mechanics on maxillary anterior teeth retraction under different implant insertion heights and different retraction hook heights. The three dimensional finite element model of maxillary anterior teeth retraction force system was constructed with CT scanning and MIMICS software and the relationships between brackets, teeth, wire and micro-implant were simulating the clinical factions. Then the initial tooth displacement was calculated when the insertion heights were 4 mm and 8 mm and the retraction hook heights were 1, 4, 7, 10 mm respectively. With retraction hook height added, the anterior teeth movement changed from lingual crown tipping to labial crown tipping and the intrusion movement was more apparent when the micro-implant was inserted in a higher location. The ideal teeth movement control could be achieved by different insertion heights of micro-implant and different retraction hook heights in straight wire retraction force system.

Movimentação de molares inferiores ancorados em mini-parafusos Mandibular molar uprighting, using mini-screw as anchorage

Directory of Open Access Journals (Sweden)

Rosana Canteras Di Matteo

2005-08-01

Full Text Available Freqüentemente a movimentação ortodôntica exige recursos adicionais de ancoragem. Os mini-parafusos têm-se apresentado como uma possível solução. O propósito deste trabalho foi estabelecer um método para a verticalização de molares inferiores inclinados para mesial, utilizando ancoragem em mini-parafusos colocados na região de linha oblíqüa externa da mandíbula. Foram selecionados três pacientes entre 40 a 48 anos (dois do gênero feminino, um do gênero masculino, com molares inferiores inclinados para mesial e distalmente posicionados às áreas edêntulas. Os pacientes foram tratados ortodonticamente durante um período de 6 a 12 meses, com técnica ortodôntica MD3. Mini-parafusos de titânio foram colocados bilateralmente com anestesia local. Uma incisão sobre a linha oblíqüa externa da mandíbula, medindo aproximadamente 1 cm foi realizada em cada lado, distalmente aos molares inclinados. Após descolamento muco-periosteal, mini-parafusos foram implantados e foram realizadas suturas deixando suas cabeças exteriorizadas. Uma semana após a remoção das suturas, cargas ortodônticas (entre 150 a 200 gramas/força foram aplicadas através de forças elásticas. Verificamos que alguma inflamação foi observada ao redor dos mini-parafusos, mas foi controlada com procedimentos de higienização. O procedimento cirúrgico é simples, podendo ser realizado pelo ortodontista; as formas dimensionais dos mini-parafusos são adequadas e estes são de fácil remoção após uso. Concluímos que o uso de mini-parafusos representa uma alternativa efetiva de ancoragem ortodôntica na verticalização de molares inferiores.Tooth movement frequently requires additional anchorage resources. Mini-screws have been used as a possible solution to this matter. The purpose of this study was to establish a method of mandibular molar uprighting, using mini-screw as anchorage, positioned on the mandibular external oblique line, behind and

Bilateral en-masse distalization of maxillary posterior teeth with skeletal anchorage: a case report

Directory of Open Access Journals (Sweden)

Saeed Noorollahian

Full Text Available ABSTRACT Objective: The aim of this study was to introduce a new method for bilateral distal movement of the entire maxillary posterior segment. Case report: A 17-year-old girl with Class I skeletal malocclusion (end-to-end molar relationships, deviated midline and space deficiency for left maxillary canine was referred for orthodontic treatment. She did not accept maxillary first premolars extraction. A modified Hyrax appliance (Dentaurum Ispringen, Germany was used for bilateral distalization of maxillary posterior teeth simultaneously. Expansion vector was set anteroposteriorly. Posterior legs of Hyrax were welded to first maxillary molar bands. All posterior teeth on each side consolidated with a segment of 0.017 × 0.025-in stainless steel wire from the buccal side. Anterior legs of Hyrax were bent into eyelet form and attached to the anterior palate with two mini-screws (2 × 10 mm (Jeil Medical Corporation Seoul, South Korea. Hyrax opening rate was 0.8 mm per month. Lateral cephalometric radiographs were used to evaluate the extent of distal movement. 3.5-mm distalization of posterior maxillary teeth was achieved in five months. Results: A nearly bodily distal movement without anchorage loss was obtained. Conclusion: The mini-screw-supported modified Hyrax appliance was found to be helpful for achieving en-masse distal movement of maxillary posterior teeth.

Anchorage strength models for end-debonding predictions in RC beams strengthened with FRP composites

Science.gov (United States)

Nardini, V.; Guadagnini, M.; Valluzzi, M. R.

2008-05-01

The increase in the flexural capacity of RC beams obtained by externally bonding FRP composites to their tension side is often limited by the premature and brittle debonding of the external reinforcement. An in-depth understanding of this complex failure mechanism, however, has not yet been achieved. With specific regard to end-debonding failure modes, extensive experimental observations reported in the literature highlight the important distinction, often neglected in strength models proposed by researchers, between the peel-off and rip-off end-debonding types of failure. The peel-off failure is generally characterized by a failure plane located within the first few millimetres of the concrete cover, whilst the rip-off failure penetrates deeper into the concrete cover and propagates along the tensile steel reinforcement. A new rip-off strength model is described in this paper. The model proposed is based on the Chen and Teng peel-off model and relies upon additional theoretical considerations. The influence of the amount of the internal tensile steel reinforcement and the effective anchorage length of FRP are considered and discussed. The validity of the new model is analyzed further through comparisons with test results, findings of a numerical investigation, and a parametric study. The new rip-off strength model is assessed against a database comprising results from 62 beams tested by various researchers and is shown to yield less conservative results.

Comparison of in-vivo failure of single-thread and dual-thread temporary anchorage devices over 18 months: A split-mouth randomized controlled trial.

Science.gov (United States)

Durrani, Owais Khalid; Shaheed, Sohrab; Khan, Arsalan; Bashir, Ulfat

2017-10-01

The purpose of this study was to compare the in-vivo failure rates of single-thread and dual-thread temporary anchorage device (TAD) designs over 18 months. Thirty patients with skeletal Class II Division 1 malocclusion requiring anchorage from TADs for retraction of maxillary incisors into the extracted premolar space were recruited in this parallel group, split-mouth, randomized controlled trial. A block randomization sequence was generated with Random Allocation Software (version 2.0; Isfahan, Iran) with the allocations concealed in sequentially numbered, opaque, sealed envelopes. A total of 60 TADs (diameter, 2 mm; length, 10 mm) were placed in the maxillary arches of these patients with random allocation of the 2 types to the left and the right sides in a 1:1 ratio. All TADs were placed between the roots of the second premolar and the first molar and were immediately loaded. Patients were followed for a minimum of 12 months and a maximum of 18 months for the failure of the TADs. Data were analyzed blindly on an intention-to-treat basis. Four TADs (13.3%) failed in the single-thread group, and 6 TADs (20%) failed in the dual-thread group. The McNemar test showed an insignificant difference (P = 0.72) between the 2 groups. An odds ratio of 1.6 (95% confidence interval, 0.39-6.97) showed no significant associations among the variables. Most TADs failed in the first month after insertion (50%). The failure rate of dual-thread TADs compared with single-thread TADs is statistically insignificant when placed in the maxilla for retraction of the anterior segment. Registration: The trial was not registered before commencement. The protocol was not published before the trial. Copyright © 2016 American Association of Orthodontists. Published by Elsevier Inc. All rights reserved.

Molecular and functional analysis of anchorage independent, treatment-evasive neuroblastoma tumorspheres with enhanced malignant properties: A possible explanation for radio-therapy resistance.

Science.gov (United States)

Abou-Antoun, Tamara J; Nazarian, Javad; Ghanem, Anthony; Vukmanovic, Stanislav; Sandler, Anthony D

2018-01-01

Despite significant advances in cancer treatment and management, more than 60% of patients with neuroblastoma present with very poor prognosis in the form of metastatic and aggressive disease. Solid tumors including neuroblastoma are thought to be heterogeneous with a sub-population of stem-like cells that are treatment-evasive with highly malignant characteristics. We previously identified a phenomenon of reversible adaptive plasticity (RAP) between anchorage dependent (AD) cells and anchorage independent (AI) tumorspheres in neuroblastoma cell cultures. To expand our molecular characterization of the AI tumorspheres, we sought to define the comprehensive proteomic profile of murine AD and AI neuroblastoma cells. The proteomic profiles of the two phenotypic cell populations were compared to each other to determine the differential protein expression and molecular pathways of interest. We report exclusive or significant up-regulation of tumorigenic pathways expressed by the AI tumorspheres compared to the AD cancer cells. These pathways govern metastatic potential, enhanced malignancy and epithelial to mesenchymal transition. Furthermore, radio-therapy induced significant up-regulation of specific tumorigenic and proliferative proteins, namely survivin, CDC2 and the enzyme Poly [ADP-ribose] polymerase 1. Bio-functional characteristics of the AI tumorspheres were resistant to sutent inhibition of receptor tyrosine kinases (RTKs) as well as to 2.5 Gy radio-therapy as assessed by cell survival, proliferation, apoptosis and migration. Interestingly, PDGF-BB stimulation of the PDGFRβ led to transactivation of EGFR and VEGFR in AI tumorspheres more potently than in AD cells. Sutent inhibition of PDGFRβ abrogated this transactivation in both cell types. In addition, 48 h sutent treatment significantly down-regulated the protein expression of PDGFRβ, MYCN, SOX2 and Survivin in the AI tumorspheres and inhibited tumorsphere self-renewal. Radio-sensitivity in AI

Use of reconstructed CT images for evaluation of the position of screw-type temporary anchorage devices implanted in the maxillary molar region

International Nuclear Information System (INIS)

Hashimoto, Kazuya

2007-01-01

Temporary anchorage devices (TAD) have recently been employed for orthodontic treatment. I attempted to find the safest position for placing the screw-type TAD in the maxillary molar region. Using reconstructed CT images, I investigated the buccolingual and mesiodistal lengths of the interalveolar septums between the maxillary first premolar, second premolar, first molar, and the second molar. For the first and second molars, I measured the distance from the alveolar crest to the maxillary sinus. The results indicated that the safest position for placing a screw-type TAD was the interalveolar septum between the maxillary first molar and the second premolar at about a depth of 4-6 mm from the alveolar crest on the buccal side, and at about a depth of 2-6 mm from the alveolar crest on the palatal side. (author)

Mesialização de molares com ancoragem em mini-implantes Mesial movement of molars with mini-implants anchorage

Directory of Open Access Journals (Sweden)

Marcos Janson

2008-10-01

Full Text Available INTRODUÇÃO: é muito comum, na rotina do consultório odontológico, especialmente em Ortodontia, o paciente, após avaliar o plano de tratamento proposto, questionar sobre a possibilidade de fechamento de espaços presentes, ocasionados pela perda de dentes permanentes. O ortodontista, frente a essa questão, tem que avaliar diversos fatores, tais como a má oclusão presente, a integridade do osso e das raízes, o tempo de tratamento e a geometria do posicionamento dentário, que é o que permite avaliar se, com o fechamento dos espaços e, conseqüentemente, a perda de ancoragem dos segmentos anteriores, a finalização estará de acordo com os ideais que regem a especialidade. Com o advento dos mini-implantes, as possibilidades desta abordagem terapêutica aumentaram, pois o efeito adverso da perda de ancoragem pode ser eliminado e, com isso, o paciente pode ser beneficiado. No entanto, os outros fatores envolvidos, assim como a mecânica do movimento, requerem especial atenção. OBJETIVOS: no presente artigo serão abordados os fatores envolvidos neste tipo de tratamento, o raciocínio na tomada de decisões e os detalhes importantes que devem ser observados durante a condução da mecânica, ilustrados com casos clínicos.INTRODUCTION: It's routine, especially at the orthodontic office, the patient, after the assessment of the proposed treatment plan, answer about the possibility of closing their edentulous spaces caused by missed permanent teeth. In these situations, several factors must be evaluated, like the present malocclusion, the bone and roots integrity, the treatment time and the geometry of teeth positioning, that is what permits to assess if the loss of anchorage from the anterior segments, during the space closure, would permit the occlusion to end within the orthodontic ideals. With the mini-implants, the possibilities of this therapeutic approach have been improved, since the adverse effects are eliminated with the

PAX2 regulates ADAM10 expression and mediates anchorage-independent cell growth of melanoma cells.

Directory of Open Access Journals (Sweden)

Sophia Boyoung Lee

Full Text Available PAX transcription factors play an important role during development and carcinogenesis. In this study, we investigated PAX2 protein levels in melanocytes and melanoma cells by Western Blot and immunofluorescence analysis and characterized the role of PAX2 in the pathogenesis of melanoma. In vitro we found weak PAX2 protein expression in keratinocytes and melanocytes. Compared to melanocytes increased PAX2 protein levels were detectable in melanoma cell lines. Interestingly, in tissue sections of melanoma patients nuclear PAX2 expression strongly correlated with nuclear atypia and the degree of prominent nucleoli, indicating an association of PAX2 with a more atypical cellular phenotype. In addition, with chromatin immunoprecipitation assay, PAX2 overexpression and PAX2 siRNA we present compelling evidence that PAX2 can regulate ADAM10 expression, a metalloproteinase known to play important roles in melanoma metastasis. In human tissue samples we found co-expression of PAX2 and ADAM10 in melanocytes of benign nevi and in melanoma cells of patients with malignant melanoma. Importantly, the downregulation of PAX2 by specific siRNA inhibited the anchorage independent cell growth and decreased the migratory and invasive capacity of melanoma cells. Furthermore, the downregulation of PAX2 abrogated the chemoresistance of melanoma cells against cisplatin, indicating that PAX2 expression mediates cell survival and plays important roles during melanoma progression.

Peptide array-based interaction assay of solid-bound peptides and anchorage-dependant cells and its effectiveness in cell-adhesive peptide design.

Science.gov (United States)

Kato, Ryuji; Kaga, Chiaki; Kunimatsu, Mitoshi; Kobayashi, Takeshi; Honda, Hiroyuki

2006-06-01

Peptide array, the designable peptide library covalently synthesized on cellulose support, was applied to assay peptide-cell interaction, between solid-bound peptides and anchorage-dependant cells, to study objective peptide design. As a model case, cell-adhesive peptides that could enhance cell growth as tissue engineering scaffold material, was studied. On the peptide array, the relative cell-adhesion ratio of NIH/3T3 cells was 2.5-fold higher on the RGDS (Arg-Gly-Asp-Ser) peptide spot as compared to the spot with no peptide, thus indicating integrin-mediated peptide-cell interaction. Such strong cell adhesion mediated by the RGDS peptide was easily disrupted by single residue substitution on the peptide array, thus indicating that the sequence recognition accuracy of cells was strictly conserved in our optimized scheme. The observed cellular morphological extension with active actin stress-fiber on the RGD motif-containing peptide supported our strategy that peptide array-based interaction assay of solid-bound peptide and anchorage-dependant cells (PIASPAC) could provide quantitative data on biological peptide-cell interaction. The analysis of 180 peptides obtained from fibronectin type III domain (no. 1447-1629) yielded 18 novel cell-adhesive peptides without the RGD motif. Taken together with the novel candidates, representative rules of ineffective amino acid usage were obtained from non-effective candidate sequences for the effective designing of cell-adhesive peptides. On comparing the amino acid usage of the top 20 and last 20 peptides from the 180 peptides, the following four brief design rules were indicated: (i) Arg or Lys of positively charged amino acids (except His) could enhance cell adhesion, (ii) small hydrophilic amino acids are favored in cell-adhesion peptides, (iii) negatively charged amino acids and small amino acids (except Gly) could reduce cell adhesion, and (iv) Cys and Met could be excluded from the sequence combination since they have

Role of postreplication repair in transformation of human fibroblasts to anchorage independence

International Nuclear Information System (INIS)

Boyer, J.C.; Kaufmann, W.K.; Cordeiro-Stone, M.

1991-01-01

Cellular capacity for postreplication repair (PRR) and sensitivity to transformation to anchorage independence (AI) were quantified in normal foreskin and xeroderma pigmentosum (XP) variant fibroblasts after treatment with UV or benzo(a)pyrene-diol-epoxide I (BPDE-I). PRR is defined here as a collection of pathways that facilitate the replication of DNA damaged by genotoxic agents. It is recognized biochemically as the process by which nascent DNA grows longer than the average distance between two lesions in the DNA template. PRR refers more directly to the elimination of gaps in the daughter-strand DNA by mechanisms which remain to be determined for human cells, but which may include translesion replication and recombination. PRR was measured in diploid human fibroblasts by analysis of the dose kinetics for inhibition of DNA strand growth in carcinogen-treated cells. Logarithmically growing foreskin fibroblasts (NHF1) displayed D0 values of 4.3 J/m 2 and 0.14 microM for the inhibition of DNA synthesis in active replicons by UV and BPDE-I, respectively. XP variant cells (CRL1162) exhibited corresponding D0 values of 1.5 J/m 2 and 0.16 microM. The increased sensitivity to inhibition of DNA replication by UV in these XP variant fibroblasts (2.9-fold greater than normal) was mirrored by an enhanced frequency of transformation to AI. XP variant fibroblasts (CRL1162) were 3.2 times more sensitive to transformation to AI by UV than were the normal foreskin fibroblasts. As predicted by the PRR studies, both cell types exhibited similar frequencies of AI colonies induced by BPDE-I. Apparent thresholds were observed for induction of AI by UV (normal fibroblasts, 2.7 J/m 2 ; XP variant fibroblasts, 0.3 J/m 2 ) and BPDE-I (both, 0.05 microM)

Automation of the Design of the Anchorage System Taking into Account the Geomechanical State of the Massif and Mining Development Schemes

Directory of Open Access Journals (Sweden)

Demin Vladimir

2018-01-01

Full Text Available The article presents the system for the automation of the design of the anchorage, which regulates the calculation of the required parameters of the fasteners for the fastening of the fastening system. The main factors affecting the operation of the anchor support are grouped in the following way: mining and geological conditions, technical characteristics of the anchor support, geomechanical conditions for conducting and operating the mine workings. Mining and geological conditions for carrying out excavations include: physical and mechanical properties of rocks, the category of roof stability, fracturing, etc. Technical characteristics of the anchor support: material of the rod, filler, filling completeness, etc. Conditions (geomechanical of carrying out and exploitation of the mine workings: the depth of the conduct, the location relative to the zone of influence of the cleaning works, the location relative to the waste zone, etc. As a result of calculations the program gives out the basic parameters of the anchor support, which coincide with the parameters adopted by the passport.

Maxillary protraction in adult cleft lip and palate by a rigid external distraction device with dentoskeletal anchorage

Science.gov (United States)

Akarsu, Bengisu; Taner, Tulin; Tuncbilek, Gokhan; Mavili, M. Emin

2012-01-01

Objective: The objective is to evaluate the effects of maxillary distraction osteogenesis (DO) in an adult patient with unilateral cleft lip and palate (UCLP) by using a rigid external distraction (RED) device with dentoskeletal anchorage. Method: 31-year-old male patient with UCLP with severe maxillary hypoplasia, dolichofacial growth pattern, negative overjet and 1.5 mm openbite. After pre-surgical orthodontic treatment, an intra-oral appliance was modified to prevent extrusion of the molars and clockwise rotation of the mandible. Stainless steel plates were soldered bilaterally to the intra oral appliance at the level of canines. During surgery, miniplates were inserted in the maxillary segment and fixed to the plates of the intra oral appliance with screws. Results: The mean distraction length was 12 mm immediately after DO. SNA increased from 73o to 82o after distraction. A significant advancement of the maxilla and correction of the sagittal Class III skeletal relationship was achieved. The vertical position of the mandible and the face was kept stable, and the soft tissue profile became more balanced. Conclusion: This intra oral appliance design achieved desired skeletal changes during maxillary protraction with RED device in dolichofacial CLP patient. Occlusion and facial profile changes was found to be stable in 1-year follow-up. PMID:22509125

Maxillary protraction in adult cleft lip and palate by a rigid external distraction device with dentoskeletal anchorage.

Science.gov (United States)

Akarsu, Bengisu; Taner, Tulin; Tuncbilek, Gokhan; Mavili, M Emin

2012-04-01

The objective is to evaluate the effects of maxillary distraction osteogenesis (DO) in an adult patient with unilateral cleft lip and palate (UCLP) by using a rigid external distraction (RED) device with dentoskeletal anchorage. 31-year-old male patient with UCLP with severe maxillary hypoplasia, dolichofacial growth pattern, negative overjet and 1.5 mm openbite. After pre-surgical orthodontic treatment, an intra-oral appliance was modified to prevent extrusion of the molars and clockwise rotation of the mandible. Stainless steel plates were soldered bilaterally to the intra oral appliance at the level of canines. During surgery, miniplates were inserted in the maxillary segment and fixed to the plates of the intra oral appliance with screws. The mean distraction length was 12 mm immediately after DO. SNA increased from 73o to 82o after distraction. A significant advancement of the maxilla and correction of the sagittal Class III skeletal relationship was achieved. The vertical position of the mandible and the face was kept stable, and the soft tissue profile became more balanced. This intra oral appliance design achieved desired skeletal changes during maxillary protraction with RED device in dolichofacial CLP patient. Occlusion and facial profile changes was found to be stable in 1-year follow-up.

Evaluation of stress patterns on maxillary posterior segment when intruded with mini implant anchorage: A three-dimensional finite element study

Directory of Open Access Journals (Sweden)

Nikhita Pekhale

2016-01-01

Full Text Available Introduction: The aim of this study is to evaluate stress and displacement effects of maxillary posterior intrusion mechanics with mini-implant anchorage by using finite element method. Materials and Methods: A computer stimulation of three-dimensional model maxilla with all teeth, PDL, bone, mini-implants, brackets, arch wire, force element, and transpalatal arch was constructed on the basis of average anatomic morphology. Finite element analysis was done to evaluate the amount of stress and its distribution during orthodontic intrusive force. Results: Increased Von Mises stress values were observed in mesio-cervical region of first molar. The middle third of second premolar and second molar and regions adjacent to force application sites also showed relatively high stress values. Minimum stress values were observed in apical region of first premolar as it is away from force application. Conclusion: Using three mini-implant and transpalatal arches, this study demonstrates that significant amount of true intrusion of maxillary molars could be obtained with lesser concentration of stresses in the apical area recorded.

Chlamydia induces anchorage independence in 3T3 cells and detrimental cytological defects in an infection model.

Directory of Open Access Journals (Sweden)

Andrea E Knowlton

Full Text Available Chlamydia are gram negative, obligate intracellular bacterial organisms with different species causing a multitude of infections in both humans and animals. Chlamydia trachomatis is the causative agent of the sexually transmitted infection (STI Chlamydia, the most commonly acquired bacterial STI in the United States. Chlamydial infections have also been epidemiologically linked to cervical cancer in women co-infected with the human papillomavirus (HPV. We have previously shown chlamydial infection results in centrosome amplification and multipolar spindle formation leading to chromosomal instability. Many studies indicate that centrosome abnormalities, spindle defects, and chromosome segregation errors can lead to cell transformation. We hypothesize that the presence of these defects within infected dividing cells identifies a possible mechanism for Chlamydia as a cofactor in cervical cancer formation. Here we demonstrate that infection with Chlamydia trachomatis is able to transform 3T3 cells in soft agar resulting in anchorage independence and increased colony formation. Additionally, we show for the first time Chlamydia infects actively replicating cells in vivo. Infection of mice with Chlamydia results in significantly increased cell proliferation within the cervix, and in evidence of cervical dysplasia. Confocal examination of these infected tissues also revealed elements of chlamydial induced chromosome instability. These results contribute to a growing body of data implicating a role for Chlamydia in cervical cancer development and suggest a possible molecular mechanism for this effect.

Comparative study of the anchorage and the catalytic properties of nanoporous TiO2 films modified with ruthenium (II) and rhenium (I) carbonyl complexes

Science.gov (United States)

Oyarzún, Diego P.; Chardon-Noblat, Sylvie; Linarez Pérez, Omar E.; López Teijelo, Manuel; Zúñiga, César; Zarate, Ximena; Shott, Eduardo; Carreño, Alexander; Arratia-Perez, Ramiro

2018-02-01

In this article we study the anchoring of cis-[Ru(bpyC4pyr)(CO)2(CH3CN)2]2+, cis-[Ru(bpy)2(CO)2]2+ and cis-[Ru(bpyac)(CO)2Cl2], onto nanoporous TiO2 employing electropolymerization, electrostatic interaction and chemical bonding. Also, the [Re(bpyac)(CO)3Cl] rhenium(I) complex for chemical anchorage was analyzed. The characterization of TiO2/Ru(II) and TiO2/Re(I) nanocomposite films was performed by field emission scanning electron microscopy (FESEM), electron dispersive X-ray spectroscopy (EDS) and Raman spectroscopy. In addition, for the more stable nanocomposites obtained, the catalytic properties (solar energy conversion and CO2 reduction) were evaluated. The efficiency improvement in redox process derived from the (photo)electrochemical evidence indicates that modified nanoporous TiO2 structures enhance the rate of charge transfer reactions.

Recorded earthquake responses from the integrated seismic monitoring network of the Atwood Building, Anchorage, Alaska

Science.gov (United States)

Celebi, M.

2006-01-01

An integrated seismic monitoring system with a total of 53 channels of accelerometers is now operating in and at the nearby free-field site of the 20-story steel-framed Atwood Building in highly seismic Anchorage, Alaska. The building has a single-story basement and a reinforced concrete foundation without piles. The monitoring system comprises a 32-channel structural array and a 21-channel site array. Accelerometers are deployed on 10 levels of the building to assess translational, torsional, and rocking motions, interstory drift (displacement) between selected pairs of adjacent floors, and average drift between floors. The site array, located approximately a city block from the building, comprises seven triaxial accelerometers, one at the surface and six in boreholes ranging in depths from 15 to 200 feet (???5-60 meters). The arrays have already recorded low-amplitude shaking responses of the building and the site caused by numerous earthquakes at distances ranging from tens to a couple of hundred kilometers. Data from an earthquake that occurred 186 km away traces the propagation of waves from the deepest borehole to the roof of the building in approximately 0.5 seconds. Fundamental structural frequencies [0.58 Hz (NS) and 0.47 Hz (EW)], low damping percentages (2-4%), mode coupling, and beating effects are identified. The fundamental site frequency at approximately 1.5 Hz is close to the second modal frequencies (1.83 Hz NS and 1.43 EW) of the building, which may cause resonance of the building. Additional earthquakes prove repeatability of these characteristics; however, stronger shaking may alter these conclusions. ?? 2006, Earthquake Engineering Research Institute.

Protein disulfide isomerases in the endoplasmic reticulum promote anchorage-independent growth of breast cancer cells.

Science.gov (United States)

Wise, Randi; Duhachek-Muggy, Sara; Qi, Yue; Zolkiewski, Michal; Zolkiewska, Anna

2016-06-01

Metastatic breast cancer cells are exposed to stress of detachment from the extracellular matrix (ECM). Cultured breast cancer cells that survive this stress and are capable of anchorage-independent proliferation form mammospheres. The purpose of this study was to explore a link between mammosphere growth, ECM gene expression, and the protein quality control system in the endoplasmic reticulum (ER). We compared the mRNA and protein levels of ER folding factors in SUM159PT and MCF10DCIS.com breast cancer cells grown as mammospheres versus adherent conditions. Publicly available gene expression data for mammospheres formed by primary breast cancer cells and for circulating tumor cells (CTCs) were analyzed to assess the status of ECM/ER folding factor genes in clinically relevant samples. Knock-down of selected protein disulfide isomerase (PDI) family members was performed to examine their roles in SUM159PT mammosphere growth. We found that cells grown as mammospheres had elevated expression of ECM genes and ER folding quality control genes. CTC gene expression data for an index patient indicated that upregulation of ECM and ER folding factor genes occurred at the time of acquired therapy resistance and disease progression. Knock-down of PDI, ERp44, or ERp57, three members of the PDI family with elevated protein levels in mammospheres, in SUM159PT cells partially inhibited the mammosphere growth. Thus, breast cancer cell survival and growth under detachment conditions require enhanced assistance of the ER protein folding machinery. Targeting ER folding factors, in particular members of the PDI family, may improve the therapeutic outcomes in metastatic breast cancer.

Comparison of short-term effects between face mask and skeletal anchorage therapy with intermaxillary elastics in patients with maxillary retrognathia.

Science.gov (United States)

Ağlarcı, Cahide; Esenlik, Elçin; Fındık, Yavuz

2016-06-01

The aim of this study was to compare the short-term dental and skeletal effects of a face mask (FM) with those of skeletal anchorage (SA) therapy with intermaxillary elastics in prepubertal patients with skeletal Class III malocclusion. Fifty patients with skeletal Class III malocclusion and maxillary deficiency were divided into two groups. In the FM group, an FM was applied by a bite plate with a force of 400g for each side. In the SA group, mini-plates were placed between mandibular lateral incisors and canines, and mini-implants were inserted between maxillary second premolars and first molars. A bite plate was inserted into the upper arch, and Class III elastics were applied with a force of 200g between each mini-plate and mini-implant. Mean treatment durations were 0.52±0.09 years for FM and 0.76±0.09 years for SA. After the treatment, statistically significant increases in SNA°, ANB°, A-y, 1-NA, SnGoGn°, Co-A, Co-Gn, and A-Nperp, and reductions in SNB° and FH┴N-Pg were observed in both groups, and these changes were similar in both groups. In the FM group, 1-NB decreased significantly, and in the SA group, it increased significantly (P journals.permissions@oup.com.

Induction of anchorage-independent growth in primary human cells exposed to protons or HZE ions separately or in dual exposures.

Science.gov (United States)

Sutherland, B M; Cuomo, N C; Bennett, P V

2005-10-01

Travelers on space missions will be exposed to a complex radiation environment that includes protons and heavy charged particles. Since protons are present at much higher levels than are heavy ions, the most likely scenario for cellular radiation exposure will be proton exposure followed by a hit by a heavy ion. Although the effects of individual ion species on human cells are being investigated extensively, little is known about the effects of exposure to both radiation types. One useful measure of mammalian cell damage is induction of the ability to grow in a semi-solid agar medium highly inhibitory to the growth of normal human cells, termed neoplastic transformation. Using primary human cells, we evaluated induction of soft-agar growth and survival of cells exposed to protons only or to heavy charged particles (600 MeV/nucleon silicon) only as well as of cells exposed to protons followed after a 4-day interval by silicon ions. Both ions alone efficiently transformed the human cells to anchorage-independent growth. Initial experiments indicate that the dose responses for neoplastic transformation of cells exposed to protons and then after 4 days to silicon ions appear similar to that of cells exposed to silicon ions alone.

The influence of social anchorage on the gender difference in the use of mental health services.

Science.gov (United States)

Drapeau, Aline; Boyer, Richard; Lesage, Alain

2009-07-01

Overall, women are more likely than men to seek professional care when they face light or moderate mental health problems. This difference is usually attributed to culture-related factors, but neither women nor men form a homogeneous cultural group. The help-seeking behavior may reflect not only the cultural values and expectations associated with a specific gender but also those associated with specific social roles endorsed by women and men. In addition, the influence of these culture-related factors on the help-seeking behavior is constrained by barriers to care, which apply similarly to women and men. In consequence, the gender difference in the use of mental health services should vary across social roles and types of service. This hypothesis was tested on data from the cycle 1.2 of the Canadian Community Health Survey. Logistic regression analyses show that, although women are more likely than men to use mental health services, this gender difference is larger for general services than for psychiatric and psychological services whose access in Canada is constrained, respectively, by systemic and financial barriers to care. They also suggest that holding the role of worker tends to foster the use of psychological services in women, especially in married women, and to a lesser degree in men, whereas it tends to hinder the use of general and psychiatric services in men but to exert no or less influence in women. Thus, professional anchorage seems to be an important source of the societal norms that influence the decision of women and men to seek or not to seek medical care for mental health problems.

Impact of radiation history, gender and age on bone quality in sites for orthodontic skeletal anchorage device placement.

Science.gov (United States)

Konermann, A; Appel, T; Wenghoefer, M; Sirokay, S; Dirk, C; Jäger, A; Götz, W

2015-05-01

Stability of orthodontic miniscrew implants is prerequisite to their success and durability in orthodontic treatment. As investigations revealed a positive correlation of miniscrew stability to periimplant bone quality, it has been the aim of this study to analyze the bone structure of resection preparations of human mandibles histologically by investigating the samples according to age, gender and exposure to radiotherapy. Inflammation- and tumor-free alveolar bone sections from human mandibles (n = 31) with previously diagnosed carcinoma, chronic osteomyelitis or cysts were analyzed histomorphologically and histomorphometrically as to the dimension of trabeculae in cancellous areas. Group A investigated the impact of a history of radiation therapy, group B of gender and group C contrasted biopsies from individuals aging under 60 or over 60 years. Statistics were performed using the Kruskal-Wallis-test. Radiation, gender and age did not significantly influence bone density. The mean bone density averaged 40.7 ± 15.0% of spongiosa for the total collective with a median age of 58.4 years ± 14.7 years. Our findings provide new information on bone quality, thus contributing to a more precise evaluation of the parameters affecting and those not affecting miniscrew implant stability. On the basis of these results, the formulation of clinical guidelines for risk assessment of therapeutic approaches in patients prior to insertion of orthodontic skeletal anchorage devices seems to be conceivable. Copyright © 2014 Elsevier GmbH. All rights reserved.

L’ancrage squelettique au passé, présent et futur

DEFF Research Database (Denmark)

Melsen, Birte; Dalstra, Michel

2017-01-01

INTRODUCTION: Skeletal anchorage was not introduced as an alternative to conventional anchorage modalities. The first skeletal anchorage was a ligature through a hole in the infrazygomatic crest. This was replaced by surgical screws and finally the TADs, which were optimized with respect to the m......INTRODUCTION: Skeletal anchorage was not introduced as an alternative to conventional anchorage modalities. The first skeletal anchorage was a ligature through a hole in the infrazygomatic crest. This was replaced by surgical screws and finally the TADs, which were optimized with respect...

Cellular Dichotomy Between Anchorage-Independent Growth Responses to bFGF and TA Reflects Molecular Switch in Commitment to Carcinogenesis

Energy Technology Data Exchange (ETDEWEB)

Waters, Katrina M.; Tan, Ruimin; Opresko, Lee K.; Quesenberry, Ryan D.; Bandyopadhyay, Somnath; Chrisler, William B.; Weber, Thomas J.

2009-11-01

We have investigated gene expression patterns underlying reversible and irreversible anchorage-independent growth (AIG) phenotypes to identify more sensitive markers of cell transformation for studies directed at interrogating carcinogenesis responses. In JB6 mouse epidermal cells, basic fibroblast growth factor (bFGF) induces an unusually efficient and reversible AIG response, relative to 12-O-tetradecanoyl phorbol-13-acetate (TPA)-induced AIG which is irreversible. The reversible and irreversible AIG phenotypes are characterized by largely non-overlapping global gene expression profiles. However, a subset of differentially expressed genes were identified as common to reversible and irreversible AIG phenotypes, including genes regulated in a reciprocal fashion. Hepatic leukemia factor (HLF) and D-site albumin promoter-binding protein (DBP) were increased in both bFGF and TPA soft agar colonies and selected for functional validation. Ectopic expression of human HLF and DBP in JB6 cells resulted in a marked increase in TPA- and bFGF-regulated AIG responses. HLF and DBP expression were increased in soft agar colonies arising from JB6 cells exposed to gamma radiation and in a human basal cell carcinoma tumor tissue, relative to paired non-tumor tissue. Subsequent biological network analysis suggests that many of the differentially expressed genes that are common to bFGF- and TPA-dependent AIG are regulated by c-Myc, SP-1 and HNF-4 transcription factors. Collectively, we have identified a potential molecular switch that mediates the transition from reversible to irreversible AIG.

Enhanced caveolin-1 expression increases migration, anchorage-independent growth and invasion of endometrial adenocarcinoma cells

International Nuclear Information System (INIS)

Diaz-Valdivia, Natalia; Bravo, Denisse; Huerta, Hernán; Henriquez, Soledad; Gabler, Fernando; Vega, Margarita; Romero, Carmen; Calderon, Claudia; Owen, Gareth I.; Leyton, Lisette; Quest, Andrew F. G.

2015-01-01

Caveolin-1 (CAV1) has been implicated both in tumor suppression and progression, whereby the specific role appears to be context dependent. Endometrial cancer is one of the most common malignancies of the female genital tract; however, little is known about the role of CAV1 in this disease. Here, we first determined by immunohistochemistry CAV1 protein levels in normal proliferative human endometrium and endometrial tumor samples. Then using two endometrial cancer cell lines (ECC: Ishikawa and Hec-1A) we evaluated mRNA and protein levels of CAV1 by real time qPCR and Western blot analysis, respectively. The role of CAV1 expression in ECC malignancy was further studied by either inducing its expression in endometrial cancer cells with the tumor promotor 12-O-tetradecanoyl-phorbol-13-acetate (4β-TPA) or decreasing expression using short-hairpin RNA constructs, and then evaluating the effects of these changes on ECC proliferation, transmigration, matrigel invasion, and colony formation in soft agar. Immunohistochemical analysis of endometrial epithelia revealed that substantially higher levels of CAV1 were present in endometrial tumors than the normal proliferative epithelium. Also, in Ishikawa and Hec-1A endometrial cancer cells CAV1 expression was readily detectable. Upon treatment with 4β-TPA CAV1 levels increased and coincided with augmented cell transmigration, matrigel invasion, as well as colony formation in soft agar. Reduction of CAV1 expression using short-hairpin RNA constructs ablated these effects in both cell types whether treated or not with 4β-TPA. Alternatively, CAV1 expression appeared not to modulate significantly proliferation of these cells. Our study shows that elevated CAV1, observed in patients with endometrial cancer, is linked to enhanced malignancy of endometrial cancer cells, as evidenced by increased migration, invasion and anchorage-independent growth. The online version of this article (doi:10.1186/s12885-015-1477-5) contains

33 CFR 110.238 - Apra Harbor, Guam.

Science.gov (United States)

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Apra Harbor, Guam. 110.238 Section 110.238 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Anchorage Grounds § 110.238 Apra Harbor, Guam. (a) The anchorage grounds (Datum: WGS...

33 CFR 110.208 - Buffalo Harbor, N.Y.

Science.gov (United States)

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Buffalo Harbor, N.Y. 110.208 Section 110.208 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Anchorage Grounds § 110.208 Buffalo Harbor, N.Y. (a) The anchorage grounds—(1...

33 CFR 110.156 - Randall Bay, Freeport, Long Island, N.Y.

Science.gov (United States)

2010-07-01

... Island, N.Y. 110.156 Section 110.156 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Anchorage Grounds § 110.156 Randall Bay, Freeport, Long Island, N.Y. (a) The anchorage grounds. Southward of a line 312 feet south of and parallel to the south side...

Apical root resorption in maxillary incisors when employing micro-implant and J-hook headgear anchorage: a 4-month radiographic study.

Science.gov (United States)

Wang, Qingzhu; Chen, Wenjing; Smales, Roger J; Peng, Hui; Hu, Xiaokun; Yin, Lu

2012-10-01

This study evaluated, over a 4-month study period, the amount of apical root resorption occurring in maxillary central incisors following their retraction when employing either micro-implant or J-hook headgear anchorage. The prospective randomised clinical trial was conducted in Orthodontic Clinic, College of Stomatology, China from 2008-2009. Subjects are patients requiring fixed appliances on waiting list (n=20). In female Han Chinese patients aged from 16-26 years, standardized periapical radiographs from 10 randomly assigned patients with maxillary protrusions comprising the micro-implant group, and from 10 similar patients comprising the J-hook headgear group, were assessed for maxillary central incisor apical root resorption. Measurements before and after orthodontic therapy were also obtained from lateral cephalometric radiographs to calculate incisor horizontal retraction and vertical intrusion distances. Estimated retraction force vectors were calculated in horizontal and vertical directions for both treatment groups. Data analysis employed t-tests and the Pearson correlation test, with α=0.05 for statistical significance. The results showed that when compared with the J-hook group, significantly more apical root resorption shortening of the maxillary central incisors was observed in the micro-implant group (1.27 mm difference, 95% CI=0.70-1.84, Pmicro-implant group resulted in significantly more apical root resorption shortening and maxillary central incisor retraction than when intermittent J-hook retraction was employed. The employment of continuous duration orthodontic forces presents a risk for increased apical root resorption that requires careful radiographic monitoring.

33 CFR 110.233 - Prince William Sound, Alaska.

Science.gov (United States)

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Prince William Sound, Alaska. 110... ANCHORAGES ANCHORAGE REGULATIONS Anchorage Grounds § 110.233 Prince William Sound, Alaska. (a) The anchorage grounds. In Prince William Sound, Alaska, beginning at a point at latitude 60°40′00″ N., longitude 146°40...

78 FR 78824 - North Pacific Fishery Management Council; Public Meeting

Science.gov (United States)

2013-12-27

...-17 at the Hilton Hotel, 500 West Third Avenue, Katmai/King Salmon, Anchorage, AK. DATES: The workshop... Anchorage Hilton Hotel, 500 West Third Avenue, Anchorage, AK. Council address: North Pacific Fishery...

A Component-Based Study of the Effect of Diameter on Bond and Anchorage Characteristics of Blind-Bolted Connections.

Directory of Open Access Journals (Sweden)

Muhammad Nasir Amin

Full Text Available Structural hollow sections are gaining worldwide importance due to their structural and architectural advantages over open steel sections. The only obstacle to their use is their connection with other structural members. To overcome the obstacle of tightening the bolt from one side has given birth to the concept of blind bolts. Blind bolts, being the practical solution to the connection hindrance for the use of hollow and concrete filled hollow sections play a vital role. Flowdrill, the Huck High Strength Blind Bolt and the Lindapter Hollobolt are the well-known commercially available blind bolts. Although the development of blind bolts has largely resolved this issue, the use of structural hollow sections remains limited to shear resistance. Therefore, a new modified version of the blind bolt, known as the "Extended Hollo-Bolt" (EHB due to its enhanced capacity for bonding with concrete, can overcome the issue of low moment resistance capacity associated with blind-bolted connections. The load transfer mechanism of this recently developed blind bolt remains unclear, however. This study uses a parametric approach to characterising the EHB, using diameter as the variable parameter. Stiffness and load-carrying capacity were evaluated at two different bolt sizes. To investigate the load transfer mechanism, a component-based study of the bond and anchorage characteristics was performed by breaking down the EHB into its components. The results of the study provide insight into the load transfer mechanism of the blind bolt in question. The proposed component-based model was validated by a spring model, through which the stiffness of the EHB was compared to that of its components combined. The combined stiffness of the components was found to be roughly equivalent to that of the EHB as a whole, validating the use of this component-based approach.

A Component-Based Study of the Effect of Diameter on Bond and Anchorage Characteristics of Blind-Bolted Connections.

Science.gov (United States)

Amin, Muhammad Nasir; Zaheer, Salman; Alazba, Abdulrahman Ali; Saleem, Muhammad Umair; Niazi, Muhammad Umar Khan; Khurram, Nauman; Amin, Muhammad Tahir

2016-01-01

Structural hollow sections are gaining worldwide importance due to their structural and architectural advantages over open steel sections. The only obstacle to their use is their connection with other structural members. To overcome the obstacle of tightening the bolt from one side has given birth to the concept of blind bolts. Blind bolts, being the practical solution to the connection hindrance for the use of hollow and concrete filled hollow sections play a vital role. Flowdrill, the Huck High Strength Blind Bolt and the Lindapter Hollobolt are the well-known commercially available blind bolts. Although the development of blind bolts has largely resolved this issue, the use of structural hollow sections remains limited to shear resistance. Therefore, a new modified version of the blind bolt, known as the "Extended Hollo-Bolt" (EHB) due to its enhanced capacity for bonding with concrete, can overcome the issue of low moment resistance capacity associated with blind-bolted connections. The load transfer mechanism of this recently developed blind bolt remains unclear, however. This study uses a parametric approach to characterising the EHB, using diameter as the variable parameter. Stiffness and load-carrying capacity were evaluated at two different bolt sizes. To investigate the load transfer mechanism, a component-based study of the bond and anchorage characteristics was performed by breaking down the EHB into its components. The results of the study provide insight into the load transfer mechanism of the blind bolt in question. The proposed component-based model was validated by a spring model, through which the stiffness of the EHB was compared to that of its components combined. The combined stiffness of the components was found to be roughly equivalent to that of the EHB as a whole, validating the use of this component-based approach.

Efficacy of transpalatal arch as an anchorage reinforcing unit during orthodontic space closure: A three-dimensional finite element study

Directory of Open Access Journals (Sweden)

Vishal Shrishail Kudagi

2017-01-01

Full Text Available Background and Objectives: Connecting the contralateral upper molars by means of a transpalatal arch (TPA is thought to decrease the tendency of the molars to move mesially in response to orthodontic force (i.e., provide orthodontic anchorage. This study was hence conducted to investigate the effects of the TPA on the displacement of the molars and stresses generated in the periodontium during orthodontic tooth movement using the finite element method (FEM. Materials and Methods: A three-dimensional (3D model was generated using medical modeling software (Mimics using the computed tomography slice images of the skull which were obtained at a slice thickness of 1 mm. From this, the finite element model was built using HyperMesh and analysis was performed using PATRAN software (MSC Software Corporation, 4675 MacArthur Court, Newport Beach, California 92660. The 3D finite element models were fabricated in two versions such as maxillary first molars including their associated periodontal ligament and alveolar bone one with TPA and another without TPA. Both were subjected to orthodontic forces, and the resultant stress patterns and displacements between the models with and without TPA were determined. Results: The stress and displacement plots in this study failed to show any significant differences in stress and displacement within the periodontium of molars, between the two models – one with TPA and the other without, in response to the orthodontic force. Interpretation and Conclusion: The results of the current finite element analysis, therefore, suggest that the presence of a TPA brings about no change in the initial dental and periodontal stress distribution and displacement.

Development, testing and installation of prestressing of the PCPV's at Hinkley Point B and Hunterston B

International Nuclear Information System (INIS)

Taylor, S.J.; Eadie, D.McD.

1976-01-01

In order to keep the walls of the PCPVs at Hinkley Point B and Hunterston B as thin as possible it was desirable to have a prestressing system which permitted close spacing of the tendons and anchorages. A seven strand tendon system was adopted in which the strands are individually anchored by the well-established wedge and barrel system. The seven anchorages bear on to a square plate which transmits the anchorage load to the concrete via a cast steel trumpet. These seven strand anchorages are arranged in groups of four and precast into a steel box as an anchorage unit with an ultimate tendon load of about 1050 tonnes. The development leading up to the adoption of this prestressing system and anchorage arrangement is described. Full size proving tests were carried out on the four tendon anchorage box unit, together with an alternative arrangement using a square helix of bonded reinforcement. Information is given on the friction tests carried out on the completed vessel, prestressing of the PCPVs and the corrosion prevention methods adopted. (author)

77 FR 68567 - Announcement of Funding Awards for the Continuum of Care Program for Fiscal Year (FY) 2011

Science.gov (United States)

2012-11-15

... Corporation... AK 208,404 Alaskan AIDS Assistance Association.. AK 104,665 Anchorage Community Mental Health AK 646,563 Services, Inc. Anchorage Community Mental Health AK 203,464 Services, Inc. Anchorage... the City of AR 43,104 Fayetteville, Arkansas. Little Rock Community Mental Health AR 562,993 Center...

33 CFR 110.25 - Salem Sound, Mass.

Science.gov (United States)

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Salem Sound, Mass. 110.25 Section 110.25 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.25 Salem Sound, Mass. (a) Beverly Harbor, north of Salem...

33 CFR 110.170 - Lockwoods Folly Inlet, N.C.

Science.gov (United States)

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Lockwoods Folly Inlet, N.C. 110.170 Section 110.170 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Anchorage Grounds § 110.170 Lockwoods Folly Inlet, N.C. (a) Explosives...

33 CFR 110.168 - Hampton Roads, Virginia and adjacent waters (Datum: NAD 83).

Science.gov (United States)

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Hampton Roads, Virginia and adjacent waters (Datum: NAD 83). 110.168 Section 110.168 Navigation and Navigable Waters COAST GUARD..., Virginia and adjacent waters (Datum: NAD 83). (a) Anchorage Grounds—(1) Anchorage A [Naval Anchorage]. The...

33 CFR 110.250 - St. Thomas Harbor, Charlotte Amalie, V.I.

Science.gov (United States)

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false St. Thomas Harbor, Charlotte... SECURITY ANCHORAGES ANCHORAGE REGULATIONS Anchorage Grounds § 110.250 St. Thomas Harbor, Charlotte Amalie.... Thomas, V.I. of the United States and approaches thereto, including all waters under its jurisdiction, as...

33 CFR 110.27 - Lynn Harbor in Broad Sound, Mass.

Science.gov (United States)

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Lynn Harbor in Broad Sound, Mass. 110.27 Section 110.27 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.27 Lynn Harbor in Broad Sound, Mass. North of...

Exterior beam-column joint study with non-conventional ...

Indian Academy of Sciences (India)

Reinforced concrete structures beam-column joints are the most critical regions in seismic prone areas. Proper reinforcement anchorage is essential to enhance the performance of the joints. An attempt has been made to appraise the performance of the anchorages and joints. The anchorages are detailed as per ACI-352 ...

33 CFR 110.31 - Hull Bay and Allerton Harbor at Hull, Mass.

Science.gov (United States)

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Hull Bay and Allerton Harbor at Hull, Mass. 110.31 Section 110.31 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.31 Hull Bay and Allerton Harbor at...

33 CFR 110.128b - Island of Hawaii, Hawaii.

Science.gov (United States)

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Island of Hawaii, Hawaii. 110.128b Section 110.128b Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.128b Island of Hawaii, Hawaii. (a) Hilo Bay...

33 CFR 110.179 - Skidaway River, Isle of Hope, Ga.

Science.gov (United States)

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Skidaway River, Isle of Hope, Ga. 110.179 Section 110.179 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Anchorage Grounds § 110.179 Skidaway River, Isle of Hope, Ga. (a) The...

33 CFR 110.129a - Apra Harbor, Guam. (Datum: WGS 84)

Science.gov (United States)

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Apra Harbor, Guam. (Datum: WGS 84) 110.129a Section 110.129a Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.129a Apra Harbor, Guam. (Datum: WGS 84) (a...

33 CFR 110.60 - Captain of the Port, New York.

Science.gov (United States)

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Captain of the Port, New York... ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.60 Captain of the Port, New York. (a) Western... point of origin. (d) New York Harbor. (1) Newark Bay, Southeast. All waters bound by the following...

33 CFR 110.128c - Island of Kauai, Hawaii.

Science.gov (United States)

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Island of Kauai, Hawaii. 110.128c Section 110.128c Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.128c Island of Kauai, Hawaii. (a) Nawiliwili Bay. The...

33 CFR 110.70a - Northeast River, North East, Md.

Science.gov (United States)

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Northeast River, North East, Md. 110.70a Section 110.70a Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.70a Northeast River, North East, Md. The water...

77 FR 47864 - Ocean Energy Safety Advisory Committee (OESC); Notice of Meeting

Science.gov (United States)

2012-08-10

...), Interior. ACTION: Notice of meeting. SUMMARY: OESC will meet at the Anchorage Marriott Downtown Hotel in..., from 8 a.m. to 1 p.m. ADDRESSES: Anchorage Marriott Downtown Hotel, 820 West 7th Avenue, Anchorage... the Office of Management and Budget's Circular No. A-63, Revised. Dated: August 1, 2012. James A...

Laser-Modified Surface Enhances Osseointegration and Biomechanical Anchorage of Commercially Pure Titanium Implants for Bone-Anchored Hearing Systems

Science.gov (United States)

Omar, Omar; Simonsson, Hanna; Palmquist, Anders; Thomsen, Peter

2016-01-01

Osseointegrated implants inserted in the temporal bone are a vital component of bone-anchored hearing systems (BAHS). Despite low implant failure levels, early loading protocols and simplified procedures necessitate the application of implants which promote bone formation, bone bonding and biomechanical stability. Here, screw-shaped, commercially pure titanium implants were selectively laser ablated within the thread valley using an Nd:YAG laser to produce a microtopography with a superimposed nanotexture and a thickened surface oxide layer. State-of-the-art machined implants served as controls. After eight weeks’ implantation in rabbit tibiae, resonance frequency analysis (RFA) values increased from insertion to retrieval for both implant types, while removal torque (RTQ) measurements showed 153% higher biomechanical anchorage of the laser-modified implants. Comparably high bone area (BA) and bone-implant contact (BIC) were recorded for both implant types but with distinctly different failure patterns following biomechanical testing. Fracture lines appeared within the bone ~30–50 μm from the laser-modified surface, while separation occurred at the bone-implant interface for the machined surface. Strong correlations were found between RTQ and BIC and between RFA at retrieval and BA. In the endosteal threads, where all the bone had formed de novo, the extracellular matrix composition, the mineralised bone area and osteocyte densities were comparable for the two types of implant. Using resin cast etching, osteocyte canaliculi were observed directly approaching the laser-modified implant surface. Transmission electron microscopy showed canaliculi in close proximity to the laser-modified surface, in addition to a highly ordered arrangement of collagen fibrils aligned parallel to the implant surface contour. It is concluded that the physico-chemical surface properties of laser-modified surfaces (thicker oxide, micro- and nanoscale texture) promote bone bonding

33 CFR 110.155 - Port of New York.

Science.gov (United States)

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Port of New York. 110.155 Section... ANCHORAGE REGULATIONS Anchorage Grounds § 110.155 Port of New York. (a) Long Island Sound—(1) Anchorage No... northwest corner of the crib icebreaker north of the New York Central Railroad Company drawbridge across...

33 CFR 110.74c - Bahia de San Juan, PR.

Science.gov (United States)

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Bahia de San Juan, PR. 110.74c Section 110.74c Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.74c Bahia de San Juan, PR. The waters of San Antonio...

77 FR 29449 - Toyota Motor Corporation, Inc., Grant of Petition for Decision of Inconsequential Noncompliance

Science.gov (United States)

2012-05-17

... to consumers and would not impair a consumer's ability to locate the lower anchorages. (2) Paragraph... consumers' ability to find the LATCH anchorages. While anchor bars are permitted to be as short as 25 mm in... longitudinal vertical plane tangent to the side of the anchorage bar. If a person were to probe the seat bight...

33 CFR 110.8 - Lake Champlain, N.Y. and Vt.

Science.gov (United States)

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Lake Champlain, N.Y. and Vt. 110... ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.8 Lake Champlain, N.Y. and Vt. (a) Ticonderoga, N.Y. An area shoreward of a line bearing 312° from Ticonderoga Light to the southeast corner of the...

33 CFR 110.120 - San Luis Obispo Bay, Calif.

Science.gov (United States)

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false San Luis Obispo Bay, Calif. 110... ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.120 San Luis Obispo Bay, Calif. (a) Area A-1. Area A-1 is the water area bounded by the San Luis Obispo County wharf, the shoreline, a line drawn...

33 CFR 110.85 - Niagara River, Youngstown, N.Y.

Science.gov (United States)

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Niagara River, Youngstown, N.Y... ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.85 Niagara River, Youngstown, N.Y. (a) Area 1... of the Niagara River at latitude 43°14′33″ N, longitude 79°03′7.5″ W; thence westerly to a point at...

Surgical management of fractured orthodontic mini- implant- a case report.

Science.gov (United States)

Desai, Manthan; Jain, Anoop; Sumra, Nida

2015-01-01

The idea of absolute anchorage has always been an elusive goal for clinicians. Orthodontic mini-implants or temporary anchorage devices allow tooth movements previously thought to be impossible or difficult. Although extensive literature exists on use of temporary anchorage devices, their failures have been hardly focused upon, especially implant fracture. The following case report describes successful management of fractured orthodontic mini-implant.

DETERMINING PULL – OUT DEFORMATIONS OF BONDED METAL ANCHORS EMBEDDED IN CONCRETE BY MEANS OF PHOTOGRAMMETRY

Directory of Open Access Journals (Sweden)

E. O. Avsar

2012-07-01

Full Text Available Chemical anchorages are applied in many engineering implementations, particularly strengthening of reinforced concrete structures. During strengthening procedure; chemical anchorages should be tested, since they supply to transfer the load between existing construction elements and newly added elements. Therefore; the study of the quality of chemical anchorages is an important issue in construction materials science. In this context; the most important experiment is to determine the pull-out loads of embedded anchorage reinforcement by applying axial loads. In this study; it is aimed to determine the displacements of steel reinforcements, embedded into concrete by using chemical anchorages, while applying axial pulling loads. In order to determine the displacements and load – deformation graphs; starting conditions and every 10 bar pressure applied conditions of the steel reinforcements were captured by the cameras. The obtained images were evaluated by using photogrammetric software. Based on the photogrammetric post-processing results, the load – deformation graphs were plotted and the loads at loss of adhesion were determined.

Determining Pull-Out Deformations by Means of an Online Photogrammetry Monitoring System

Directory of Open Access Journals (Sweden)

Emin Özgür Avşar

2015-03-01

Full Text Available Chemical anchorages are applied in many engineering implementations, particularly strengthening of reinforced concrete structures. During strengthening procedure; chemical anchorages should be tested, since they supply to transfer the load between existing construction elements and newly added elements. Therefore; the study of the quality of chemical anchorages is an important issue in construction materials science. In this context; the most important experiment is to determine the pull-out loads of embedded anchorage reinforcement by applying axial loads. In this study; it is aimed to determine the displacements of steel reinforcements, embedded into concrete by using chemical anchorages, while applying axial pulling loads. In order to determine the displacements and load - deformation graphs; starting conditions and every 10 bar pressure applied conditions of the steel reinforcements were captured by the cameras. The obtained images were evaluated by using photogrammetric software. Based on the photogrammetric post-processing results, the load - deformation graphs were plotted and the loads at loss of adhesion were determined

33 CFR 110.150 - Block Island Sound, N.Y.

Science.gov (United States)

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Block Island Sound, N.Y. 110.150... ANCHORAGE REGULATIONS Anchorage Grounds § 110.150 Block Island Sound, N.Y. (a) The anchorage ground. A 3/4... following coordinates: latitude 41°06′12″ N., longitude 72°00′05″ W., latitude 41°07′40″ N., longitude 72°01...

Application of pre-stressed technology in the crossing construction of the China–Myanmar Gas Pipeline

Directory of Open Access Journals (Sweden)

Xuejun Wang

2015-01-01

Full Text Available Concrete structure is commonly used in the anchorages of a large cable-suspended pipeline crossing construction. With the increase of span and load, the stress on the concrete anchorages may rise rapidly. In case of traditional anchoring structure fixed by anchor rods, concrete cracking will occur, thereby reducing the anchorage life. To solve this problem, the pre-stressed structure was designed to effectively improve the efficiency of anchoring and reduce engineering cost. In the crossing construction of China–Myanmar Gas Pipeline, the pre-stressed technology was used to establish an effective pre-stressed anchoring system, which integrates the pre-stressed structures (e.g. tunnel anchorages in the anchors and the optimization measures (e.g. positioning mode, anchorage structure, concrete placement, pre-stressed, and medium injection, in line with the crossing structure and load features of this project. The system can delay the occurrence of concrete cracking and enhance the stress durability of the structure and anchoring efficiency. This technology has been successfully applied in the crossing construction of China–Myanmar Gas Pipeline, with good economic and social benefits, indicating that this technology is a new effective solution to the optimization of suspended pipeline anchorage structures, providing technical support for the development of pipeline crossing structure.

Alaska State Commission for Human Rights

Science.gov (United States)

Harassment Poster Filing a Complaint with the Commission Public Hearing Cases Accusations Decisions Public . vs. Anchorage Plumbing and Heating Vilma Anderson vs. Anchorage School District Robin Block vs. Pulse

Diacylglycerol kinase α mediates 17-β-estradiol-induced proliferation, motility, and anchorage-independent growth of Hec-1A endometrial cancer cell line through the G protein-coupled estrogen receptor GPR30.

Science.gov (United States)

Filigheddu, Nicoletta; Sampietro, Sara; Chianale, Federica; Porporato, Paolo E; Gaggianesi, Miriam; Gregnanin, Ilaria; Rainero, Elena; Ferrara, Michele; Perego, Beatrice; Riboni, Francesca; Baldanzi, Gianluca; Graziani, Andrea; Surico, Nicola

2011-12-01

Increased levels of endogenous and/or exogenous estrogens are one of the well known risk factors of endometrial cancer. Diacylglycerol kinases (DGKs) are a family of enzymes which phosphorylate diacylglycerol (DAG) to produce phosphatidic acid (PA), thus turning off and on DAG-mediated and PA-mediated signaling pathways, respectively. DGK α activity is stimulated by growth factors and oncogenes and is required for chemotactic, proliferative, and angiogenic signaling in vitro. Herein, using either specific siRNAs or the pharmacological inhibitor R59949, we demonstrate that DGK α activity is required for 17-β-estradiol (E2)-induced proliferation, motility, and anchorage-independent growth of Hec-1A endometrial cancer cell line. Impairment of DGK α activity also influences basal cell proliferation and growth in soft agar of Hec-1A, while it has no effects on basal cell motility. Moreover, we show that DGK α activity induced by E2, as well as its observed effects, are mediated by the G protein-coupled estrogen receptor GPR30 (GPER). These findings suggest that DGK α may be a potential target in endometrial cancer therapy. Copyright © 2011 Elsevier Inc. All rights reserved.

77 FR 303 - Sunshine Act Notice

Science.gov (United States)

2012-01-04

...: Sheraton Anchorage Hotel, 401 E. 6th Avenue, Anchorage, AK 99501; telephone: (907) 276-8700; fax: (907) 343... limited to discussions of internal agency processes, personnel, and the budget of the Commission. All...

76 FR 71321 - North Pacific Fishery Management Council; Public Meetings

Science.gov (United States)

2011-11-17

... public meetings, December 5-13, 2011 at the Anchorage Hilton Hotel. DATES: The Council will begin its... sessions. ADDRESSES: The meetings will be held at the Hilton Hotel, 500 West Third Avenue, Anchorage, AK...

Anchorages - USACE IENC

Data.gov (United States)

Department of Homeland Security — These inland electronic Navigational charts (IENCs) were developed from available data used in maintenance of Navigation channels. Users of these IENCs should be...

Do Open Reduction and Internal Fixation With Articular Disc Anatomical Reduction and Rigid Anchorage Manifest a Promising Prospect in the Treatment of Intracapsular Fractures?

Science.gov (United States)

Cai, Bo-Lei; Ren, Rong; Yu, Hong-Bo; Liu, Peng-Chao; Shen, Steve G F; Shi, Jun

2018-05-01

In response to the increased attention to soft tissue reduction in the treatment of intracapsular condylar fractures (ICFs), a modified open reduction technique is proposed and its functional and radiographic outcomes were evaluated in this study. This is a retrospective case series study of patients with all ICF types that were treated with open reduction and internal fixation (ORIF) with articular disc anatomic reduction and rigid anchorage. Inclusion and exclusion criteria were strictly applied. Preoperative and postoperative clinical examinations of malocclusion, maximum incisor opening (MIO), laterotrusion, and temporomandibular disorder symptoms were recorded and analyzed. Computed tomography (CT) and magnetic resonance imaging (MRI) were used to assess articular position and condylar morphology and position. Thirty-four patients with ICFs (47 sides) were treated with the modified ORIF technique. At 6 months of follow-up, no malocclusion was found and the MIO considerably expanded to 3.56 ± 0.13 cm. Only 4 patients (12%) had temporomandibular joint discomfort with mouth opening. Interestingly, for unilateral type B ICFs, the laterotrusion distance to the ORIF sides was notably longer than to the non-ORIF sides. Postoperative CT and MRI showed that all fragments were properly reduced and the condyles were in the normal position. Postoperative anterior disc displacement occurred in 4 sides and condylar morphologic abnormalities (slight surface roughening and articular cartilage absorption) occurred in 3 sides (6.4%). This modified ORIF technique, which achieved good outcomes after treatment of all ICF types, shows promise for the treatment of ICFs. Copyright © 2018 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.

K.S. Micro‑Implant Placement Guide

African Journals Online (AJOL)

after being injured by temporary orthodontic anchorage devices,[3] ... and does not disturb the existing appliance system, clearly ... The wire guide is fabricated using round 0.018 or 0.020 ... their clinical efficiency in anchorage control.

75 FR 55309 - Procurement List Proposed Additions

Science.gov (United States)

2010-09-10

... . SUPPLEMENTARY INFORMATION: This notice is published pursuant to 41 U.S.C 47(a)(2) and 41 CFR 51-2.3. Its purpose..., Anchorage, AK. NPA: MQC Enterprises, Inc., Anchorage, AK. Contracting Activity: Dept of Transportation...

XIAP BIR domain suppresses miR-200a expression and subsequently promotes EGFR protein translation and anchorage-independent growth of bladder cancer cell

Directory of Open Access Journals (Sweden)

Chao Huang

2017-01-01

Full Text Available Abstract Background The X-linked inhibitor of apoptosis protein (XIAP is a well-known potent apoptosis suppressor and also participates in cancer cell biological behaviors, therefore attracting great attentions as a potential antineoplastic therapeutic target for past years. Anti-IAP therapy is reported to be closely related to epidermal growth factor receptor (EGFR expression level. However, whether and how XIAP modulates EGFR expression remains largely unknown. Methods Human XIAP was knockdown with short-hairpin RNA in two different bladder cancer cell lines, T24T and UMUC3. Two XIAP mutants, XIAP ∆BIR (deletion of N-terminal three BIR domains and XIAP ∆RING (deletion of C-terminal RING domain and keeping the function of BIR domains, were generated to determine which domain is involved in regulating EGFR. Results We found here that lacking of XIAP expression resulted in a remarkable suppression of EGFR expression, consequently leading to the deficiency of anchorage-independent cell growth. Further study demonstrated that BIR domain of XIAP was crucial for regulating the EGFR translation by suppressing the transcription and expression of miR-200a. Mechanistic studies indicated that BIR domain activated the protein phosphatase 2 (PP2A activity by decreasing the phosphorylation of PP2A at Tyr307 in its catalytic subunit, PP2A-C. Such activated PP2A prevented the deviant phosphorylation and activation of MAPK kinases/MAPKs, their downstream effector c-Jun, and in turn inhibiting transcription of c-Jun-regulated the miR-200a. Conclusions Our study uncovered a novel function of BIR domain of XIAP in regulating the EGFR translation, providing significant insight into the understanding of the XIAP overexpression in the cancer development and progression, further offering a new theoretical support for using XIAP BIR domain and EGFR as targets for cancer therapy.

Orthodontic intrusion : Conventional and mini-implant assisted intrusion mechanics

Directory of Open Access Journals (Sweden)

Anup Belludi

2012-01-01

intrusion has revolutionized orthodontic anchorage and biomechanics by making anchorage perfectly stable. This article addresses various conventional clinical intrusion mechanics and especially intrusion using mini-implants that have proven effective over the years for intrusion of maxillary anteriors.

76 FR 25308 - Marine Mammals

Science.gov (United States)

2011-05-04

...-XA165 Marine Mammals AGENCY: National Marine Fisheries Service (NMFS), National Oceanic and Atmospheric... Jennifer Burns, Ph.D., University of Alaska Anchorage, Biology Department, 3101 Science Circle, Anchorage, AK, has been issued a permit to conduct [[Page 25309

Penutupan Ruang Pasca Pencabutan pada Perawatan Ortodonti

Directory of Open Access Journals (Sweden)

Monica GA Monica GA

2015-10-01

Full Text Available Orthodontic space closure of every single patient should be planned individually based on the diagnosis and treatment plan. Failure on this procedure due to anchorage loss will inhibit correction of the bimaxillary protrusion because mesial movement of the posterior teeth occupied most of the premolar extraction space. The diagnosis and treatment plan should be considered carefully especially those of the ampunt of crowding, anchorage, axial inclination of canine and incisors, midline discrepancies and left/right symmetry, also the vertical dimension. In general there were two methods of space closure, non-sliding mechanics and sliding mechanics. To achieve space closure with the teeth desired, we must planned the anchorage control strategies. Differential force system are an excellent means in anchorage control, where the M/F ratio of the anchor teeth must be stronger than the teeth which moved.

Study of the interactions between a proline-rich protein and a flavan-3-ol by NMR: residual structures in the natively unfolded protein provides anchorage points for the ligands.

Science.gov (United States)

Pascal, Christine; Paté, Franck; Cheynier, Véronique; Delsuc, Marc-André

2009-09-01

Astringency is one of the major organoleptic properties of food and beverages that are made from plants, such as tea, chocolate, beer, or red wine. This sensation is thought to be due to interactions between tannins and salivary proline-rich proteins, which are natively unfolded proteins. A human salivary proline-rich protein, namely IB-5, was produced by the recombinant method. Its interactions with a model tannin, epigallocatechin gallate (EGCG), the major flavan-3-ol in green tea, were studied here. Circular dichroism experiments showed that IB-5 presents residual structures (PPII helices) when the ionic strength is close to that in saliva. In the presence of these residual structures, IB-5 undergoes an increase in structural content upon binding to EGCG. NMR data corroborated the presence of preformed structural elements within the protein prior to binding and a partial assignment was proposed, showing partial structuration. TOCSY experiments showed that amino acids that are involved in PPII helices are more likely to interact with EGCG than those in random coil regions, as if they were anchorage points for the ligand. The signal from IB-5 in the DOSY NMR spectrum revealed an increase in polydispersity upon addition of EGCG while the mean hydrodynamic radius remained unchanged. This strongly suggests the formation of IB-5/EGCG aggregates.

75 FR 66787 - Notice of Filing of Plats of Survey, Alaska

Science.gov (United States)

2010-10-29

... Office, 222 W. 7th Ave., Anchorage, AK 99513-7599. FOR FURTHER INFORMATION CONTACT: Frank A. Hardt, 907... identified in the Agreement of the Parties in United States v. City of Anchorage, et al., Civil No. A-47-65...

75 FR 54092 - North Pacific Fishery Management Council; Public Meeting

Science.gov (United States)

2010-09-03

... 28th, 2010 at the Anchorage Hilton Hotel. DATES: The meeting will be held on September 28, 2010, from 9 a.m. to 5 p.m. ADDRESSES: The meeting will be held at the Anchorage Hilton Hotel, 500 West 3rd...

An Innovative Treatment Strategy to Counteract Retroactive Forces In Bimaxillary Dentoalveolar Cases

Directory of Open Access Journals (Sweden)

Reena R Kumar

2010-01-01

This paper presents a case report of a 30 yrs old male patient with Class I Bimaxillary Protrusion treated using innovative lingual forces with a labial appliance (without any additional intraoral or extraoral anchorage devices effectively with negligible anchorage loss.

78 FR 14984 - Marine Mammals; File No. 17411

Science.gov (United States)

2013-03-08

... DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration RIN 0648-XC541 Marine Mammals; File No. 17411 AGENCY: National Marine Fisheries Service (NMFS), National Oceanic and Atmospheric.... Jennifer Burns, University of Alaska Anchorage, Biology Department, Anchorage, AK, has applied in due form...

Barriers and facilitators to the implementation of orthodontic mini-implants in clinical practice: a protocol for a systematic review and meta-analysis

NARCIS (Netherlands)

Meursinge Reynders, Reint; Ronchi, Laura; Ladu, Luisa; Di Girolamo, Nicola; de Lange, Jan; Roberts, Nia; Mickan, Sharon

2016-01-01

Most orthodontic treatment plans need some form of anchorage to control the reciprocal forces of tooth movement. Orthodontic mini implants (OMIs) have been hailed for having revolutionized orthodontics, because they provide anchorage without depending on the collaboration of patients, they have a

Caracterização de mini-implantes utilizados na ancoragem ortodôntica Characterization of the mini-implants used to orthodontic anchorage

Directory of Open Access Journals (Sweden)

Luciana Rougemont Squeff

2008-10-01

Full Text Available INTRODUÇÃO: o diâmetro reduzido do mini-implante, e a decorrente facilidade na sua inserção, minimizam a possibilidade de erro do operador e de contato entre a rosca do mini-implante e a raiz dentária. Entretanto, o risco de fratura da peça aumenta à medida que seu diâmetro é diminuído. MÉTODOS: neste trabalho foram analisados quatro produtos de marcas nacionais (INP, SIN, Conexão e Neodente e um de marca alemã (Mondeal, com o objetivo de identificar características importantes para o bom desempenho deste recurso como acessório de ancoragem. Foram observados composição e design das peças e realizado o ensaio mecânico de torque até a fratura (estudo in vitro, cujos valores foram submetidos à análise de variância (ANOVA e teste de Tukey. RESULTADOS: os resultados mostraram que todos os mini-implantes testados estão aptos à utilização clínica como reforço de ancoragem ortodôntica.INTRODUCTION: The reduced diameter of the mini-implants and the simplicity of the technique could minimize the operator mistake's possibility and avoid the contact between the thread of the screw and the dental root. In spite of that, it increases the fracture risk because of the diameter's decrease. METHODS: At the present work, mini-implants from five different trade marks, four Brazilian systems (INP, SIN, Conexão and Neodente and a German system (Mondeal were studied to identify important characteristics of this anchorage accessory, like composition, design and resistance to the insertion torque (in vitro. The values obtained from the mechanical torque test were submitted to variance analysis (ANOVA and Tukey's test. RESULTS: All studied groups presented good results and are recommended to orthodontic clinic use.

Transversely Compressed- and Restrained Shear Joints

DEFF Research Database (Denmark)

Schmidt, Jacob Wittrup; Hansen, Christian Skodborg

2013-01-01

Anchorage of FRP strengthening systems where the deformation perpendicular to the FRP material is restrained or a compressive force is applied on the strengthening, seems to provide ductility, increased utilization of the FRP and failure modes which can be controlled through the anchorage method....

49 CFR 176.2 - Definitions.

Science.gov (United States)

2010-10-01

... not penetrate accommodations, machinery spaces or other work areas by means of entrances or other... cargo, to prevent damage during transportation. Explosives anchorage means an anchorage so designated... whose stowage together may result in undue hazards in the case of leakage, spillage, or other accident...

77 FR 48159 - Tribal Consultation Meeting

Science.gov (United States)

2012-08-13

... Anchorage Hotel, 500 West Third Avenue, Anchorage, AK 99501. FOR FURTHER INFORMATION CONTACT: Ann Linehan... convention. As much as possible, OHS Tribal Consultations are scheduled in conjunction with other Tribal... delivery of Head Start services in their geographic locations. In addition, OHS will share actions taken...

7 CFR Exhibit J to Subpart A of... - Manufactured Home Sites, Rental Projects and Subdivisions: Development, Installation and Set-Up

Science.gov (United States)

2010-01-01

.... Resistance to Wind. Foundations and anchorages shall be designed to resist wind forces specified in American National Standards Institute (ANSI) A-58.1-1982 for the geographic area in which the manufactured home will..., within allowable stress and settlement limitations, all applicable loads. Any foundation and anchorage...

Development of Mechanical Anchor for CFRP Tendons Using Integrated Sleeve

DEFF Research Database (Denmark)

Schmidt, Jacob Wittrup; Bennitz, Anders; Täljsten, Björn

2010-01-01

in the longitudinal direction. Evaluation of the failure modes during testing was one of the main keys in achieving an increasingly better performance of the anchorage until the final anchorage was developed. The obtained failure modes are therefore described to enlighten the importance of addressing them when...

Miniscrew implant applications in contemporary orthodontics

Directory of Open Access Journals (Sweden)

Hong-Po Chang

2014-03-01

Full Text Available The need for orthodontic treatment modalities that provide maximal anchorage control but with minimal patient compliance requirements has led to the development of implant-assisted orthodontics and dentofacial orthopedics. Skeletal anchorage with miniscrew implants has no patient compliance requirements and has been widely incorporated in orthodontic practice. Miniscrew implants are now routinely used as anchorage devices in orthodontic treatment. This review summarizes recent data regarding the interpretation of bone data (i.e., bone quantity and quality obtained by preoperative diagnostic computed tomography (CT or by cone-beam computed tomography (CBCT prior to miniscrew implant placement. Such data are essential when selecting appropriate sites for miniscrew implant placement. Bone characteristics that are indications and contraindications for treatment with miniscrew implants are discussed. Additionally, bicortical orthodontic skeletal anchorage, risks associated with miniscrew implant failure, and miniscrew implants for nonsurgical correction of occlusal cant or vertical excess are reviewed. Finally, implant stability is compared between titanium alloy and stainless steel miniscrew implants.

Early loading of plalatal implants (ortho-type II a prospective multicenter randomized controlled clinical trial

Directory of Open Access Journals (Sweden)

Gedrange Tomasz

2007-09-01

Full Text Available Abstract Background In orthodontic treatment, anchorage control is a fundamental aspect. Usually conventional mechanism for orthodontic anchorage control can be either extraoral or intraoral that is headgear or intermaxillary elastics. Their use are combined with various side effects such as tipping of occlusal plane or undesirable movements of teeth. Especially in cases, where key-teeth are missing, conventional anchorage defined as tooth-borne anchorage will meet limitations. Therefore, the use of endosseous implants for anchorage purposes are increasingly used to achieve positional stability and maximum anchorage. Methods/Design The intended study is designed as a prospective, multicenter randomized controlled trial (RCT, comparing and contrasting the effect of early loading of palatal implant therapy versus implant loading after 12 weeks post implantation using the new ortho-implant type II anchor system device (Orthosystem Straumann, Basel, Switzerland. 124 participants, mainly adult males or females, whose diagnoses require temporary stationary implant-based anchorage treatment will be randomized 1:1 to one of two treatment groups: group 1 will receive a loading of implant standard therapy after a healing period of 12 week (gold standard, whereas group 2 will receive an early loading of orthodontic implants within 1 week after implant insertion. Participants will be at least followed for 12 months after implant placement. The primary endpoint is to investigate the behavior of early loaded palatal implants in order to find out if shorter healing periods might be justified to accelerate active orthodontic treatment. Secondary outcomes will focus e.g. on achievement of orthodontic treatment goals and quantity of direct implant-bone interface of removed bone specimens. As tertiary objective, a histologic and microtomography evaluation of all retrieved implants will be performed to obtain data on the performance of the SLA surface in human bone

Surgical Difficulties, Success, and Complication Rates of ...

African Journals Online (AJOL)

2017-05-22

May 22, 2017 ... and its control is essential for successful treatment outcomes.[2] Implants ... anchorage devices in orthodontics to treat Class II and III malocclusion ... miniplate anchorage systems: Experience with 382 miniplates. Niger. J Clin Pract .... elongated the plate arms by orthodontic wires and then patients used ...

75 FR 10223 - Procurement List Proposed Additions and Deletions

Science.gov (United States)

2010-03-05

....gov . SUPPLEMENTARY INFORMATION: This notice is published pursuant to 41 U.S.C. 47(a)(2) and 41 CFR 51... Services, Alaska VA Healthcare System and Regional Office, Anchorage, AK NPA: MQC Enterprises, Inc., Anchorage, AK Contracting Activity: Department of Veterans Affairs, Network Business Office (10N20VBO...

33 CFR 110.232 - Southeast Alaska.

Science.gov (United States)

2010-07-01

... explosives anchorage. (5) A wooden vessel must: (i) Be fitted with a radar reflector screen of metal of sufficient size to permit target indication on the radar screen of commercial type radar; or (ii) Have steel... 110.232 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES...

33 CFR 110.77 - Amistad Reservoir, Tex.

Science.gov (United States)

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Amistad Reservoir, Tex. 110.77... ANCHORAGE REGULATIONS Special Anchorage Areas § 110.77 Amistad Reservoir, Tex. (a) Diablo East, Tex. That portion of the Amistad Reservoir enclosed by a line connecting the following points, excluding a 300-foot...

76 FR 55325 - Approval and Promulgation of State Implementation Plans: Alaska

Science.gov (United States)

2011-09-07

... discontinuing the I/M program in Anchorage as an active control measure in the SIP and shifting it to a...'' system, which means the EPA will not know your identity or contact information unless you provide it in... discontinuing the I/M program in Anchorage as an active [[Page 55327

Valuing Residential Energy Efficiency in Two Alaska Real Estate Markets: A Hedonic Approach

Science.gov (United States)

Pride, Dominique J.

Alaska households have high home energy consumption and expenditures. Improving the energy efficiency of the housing stock can reduce home energy consumption, thereby reducing home energy expenditures and CO2 emissions. Improving the energy efficiency of a home may also increase its transaction price if the energy efficiency improvements are capitalized into the value of the home. The relationship between energy efficiency and transaction prices in the Fairbanks and Anchorage, Alaska residential real estate markets is examined. Using a hedonic pricing framework and difference-in-differences analysis, the impact of the Alaska Home Energy Rebate program on the transaction prices of single-family homes in the Fairbanks and Anchorage housing markets from 2008 through 2015 is examined. The results indicate that compared to homes that did not complete the program, homes that completed the program sell for a statistically significant price premium between 15.1% and 15.5% in the Fairbanks market and between 5% and 11% in the Anchorage market. A hedonic pricing framework is used to relate energy efficiency ratings and transaction prices of homes in the Fairbanks and Anchorage residential real estate markets from 2008 through 2015. The results indicate that homes with above-average energy efficiency ratings sell for a statistically significant price premium between 6.9% and 17.5% in the Fairbanks market and between 1.8% and 6.0% in the Anchorage market.

33 CFR 110.145 - Narragansett Bay, R.I.

Science.gov (United States)

2010-07-01

... area. Fixed mooring piles or stakes will not be allowed. (2) Anchorage B. Off the west shore of... mooring piles or stakes will not be allowed. (ii) Anchorage X-1, Naval explosives and ammunition handling... buoys for marking anchors or moorings in place will be allowed in this area. Fixed mooring piles or...

Effectiveness of en masse versus two-step retraction: a systematic review and meta-analysis

Directory of Open Access Journals (Sweden)

Mumen Z. Rizk

2018-01-01

Full Text Available Abstract Background This review aims to compare the effectiveness of en masse and two-step retraction methods during orthodontic space closure regarding anchorage preservation and anterior segment retraction and to assess their effect on the duration of treatment and root resorption. Methods An electronic search for potentially eligible randomized controlled trials and prospective controlled trials was performed in five electronic databases up to July 2017. The process of study selection, data extraction, and quality assessment was performed by two reviewers independently. A narrative review is presented in addition to a quantitative synthesis of the pooled results where possible. The Cochrane risk of bias tool and the Newcastle-Ottawa Scale were used for the methodological quality assessment of the included studies. Results Eight studies were included in the qualitative synthesis in this review. Four studies were included in the quantitative synthesis. En masse/miniscrew combination showed a statistically significant standard mean difference regarding anchorage preservation − 2.55 mm (95% CI − 2.99 to − 2.11 and the amount of upper incisor retraction − 0.38 mm (95% CI − 0.70 to − 0.06 when compared to a two-step/conventional anchorage combination. Qualitative synthesis suggested that en masse retraction requires less time than two-step retraction with no difference in the amount of root resorption. Conclusions Both en masse and two-step retraction methods are effective during the space closure phase. The en masse/miniscrew combination is superior to the two-step/conventional anchorage combination with regard to anchorage preservation and amount of retraction. Limited evidence suggests that anchorage reinforcement with a headgear produces similar results with both retraction methods. Limited evidence also suggests that en masse retraction may require less time and that no significant differences exist in the amount of root

76 FR 13234 - Investigations Regarding Certifications of Eligibility To Apply for Worker Adjustment Assistance...

Science.gov (United States)

2011-03-10

... Plastics Richmond, KY 02/14/11 02/11/11. (Company). 75260 Pittsburgh Corning Port Allegany, PA..... 02/14.../One- Stop). 75287 Anchorage Daily News (State/ Anchorage, AK......... 02/15/11 02/14/11. One-Stop...). 75300 Key Plastics, LLC (Company) Hartford City, IN..... 02/15/11 02/14/11. 75301 Springs Global US, Inc...

Anchorage in concrete construction

CERN Document Server

Eligehausen, Rolf; Silva, John F

2013-01-01

A comprehensive treatment of current fastening technology using inserts (anchor channels, headed stud), anchors (metal expansion anchor, undercut anchor, bonded anchor, concrete screw and plastic anchor) as well as power actuated fasteners in concrete. It describes in detail the fastening elements as well as their effects and load-bearing capacities in cracked and non-cracked concrete. It further focuses on corrosion behaviour, fire resistance and characteristics with earthquakes and shocks. It finishes off with the design of fastenings according to the European Technical Approval Guideline (ETAG 001), the Final Draft of the CEN Technical Specification 'Design of fastenings for use in concrete' and the American Standards ACI 318-05, Appendix D and ACI 349-01, Appendix B.

33 CFR 110.212 - Newport Bay Harbor, Calif.

Science.gov (United States)

2010-07-01

... Anchorage C-2. A parallelogram-shaped area, 100 feet wide and 400 feet long, lying 100 feet bayward from and... parallelogram-shaped area, 100 feet wide and 500 feet long, lying 100 feet bayward from and parallel to the... grounds—(1) Temporary Anchorage C-1. Southeast of a line parallel to and 170 feet from the pierhead line...

Pedicle Screw Fixation Study in Immature Porcine Spines to Improve Pullout Resistance during Animal Testing.

Directory of Open Access Journals (Sweden)

Sophie Le Cann

Full Text Available The porcine model is frequently used during development and validation of new spinal devices, because of its likeness to the human spine. These spinal devices are frequently composed of pedicle screws with a reputation for stable fixation but which can suffer pullouts during preclinical implantation on young animals, leading to high morbidity. With a view to identifying the best choices to optimize pedicle screw fixation in the porcine model, this study evaluates ex vivo the impact of weight (age of the animal, the level of the vertebrae (lumbar or thoracic and the type of screw anchorage (mono- or bi-cortical on pedicle screw pullouts. Among the 80 pig vertebrae (90- and 140-day-old tested in this study, the average screw pullout forces ranged between 419.9N and 1341.2N. In addition, statistical differences were found between test groups, pointing out the influence of the three parameters stated above. We found that the the more caudally the screws are positioned (lumbar level, the greater their pullout resistance is, moreover, screw stability increases with the age, and finally, the screws implanted with a mono-cortical anchorage sustained lower pullout forces than those implanted with a bi-cortical anchorage. We conclude that the best anchorage can be obtained with older animals, using a lumbar fixation and long screws traversing the vertebra and inducing bi-cortical anchorage. In very young animals, pedicle screw fixations need to be bi-cortical and more numerous to prevent pullout.

Pedicle Screw Fixation Study in Immature Porcine Spines to Improve Pullout Resistance during Animal Testing.

Science.gov (United States)

Le Cann, Sophie; Cachon, Thibaut; Viguier, Eric; Miladi, Lotfi; Odent, Thierry; Rossi, Jean-Marie; Chabrand, Patrick

2015-01-01

The porcine model is frequently used during development and validation of new spinal devices, because of its likeness to the human spine. These spinal devices are frequently composed of pedicle screws with a reputation for stable fixation but which can suffer pullouts during preclinical implantation on young animals, leading to high morbidity. With a view to identifying the best choices to optimize pedicle screw fixation in the porcine model, this study evaluates ex vivo the impact of weight (age) of the animal, the level of the vertebrae (lumbar or thoracic) and the type of screw anchorage (mono- or bi-cortical) on pedicle screw pullouts. Among the 80 pig vertebrae (90- and 140-day-old) tested in this study, the average screw pullout forces ranged between 419.9N and 1341.2N. In addition, statistical differences were found between test groups, pointing out the influence of the three parameters stated above. We found that the the more caudally the screws are positioned (lumbar level), the greater their pullout resistance is, moreover, screw stability increases with the age, and finally, the screws implanted with a mono-cortical anchorage sustained lower pullout forces than those implanted with a bi-cortical anchorage. We conclude that the best anchorage can be obtained with older animals, using a lumbar fixation and long screws traversing the vertebra and inducing bi-cortical anchorage. In very young animals, pedicle screw fixations need to be bi-cortical and more numerous to prevent pullout.

Environmental Assessment for Watershed Enhancements at Joint Base Elmendorf-Richardson

Science.gov (United States)

2013-07-03

and disposed at the Anchorage Regional Landfill . Dead fish observed after break-up in the spring will again be collected and disposed. Rotenone...Trout Stocking: A Literature Review with Special Reference to Washington Department of Game’s Lake Rehabilitation Program. Fisheries Management Report...office, Anchorage, Alaska. Davis, R. 1973. Report on the Rehabilitation of Otter Lake. October 15. Elmendorf Aero Club. 2010. Standard Operating

Stone cladding engineering

CERN Document Server

Sousa Camposinhos, Rui de

2014-01-01

This volume presents new methodologies for the design of dimension stone based on the concepts of structural design while preserving the excellence of stonemasonry practice in façade engineering. Straightforward formulae are provided for computing action on cladding, with special emphasis on the effect of seismic forces, including an extensive general methodology applied to non-structural elements. Based on the Load and Resistance Factor Design Format (LRDF), minimum slab thickness formulae are presented that take into consideration stress concentrations analysis based on the Finite Element Method (FEM) for the most commonly used modern anchorage systems. Calculation examples allow designers to solve several anchorage engineering problems in a detailed and objective manner, underlining the key parameters. The design of the anchorage metal parts, either in stainless steel or aluminum, is also presented.

Ground-Based Midcourse Defense (GMD) Sea-Based X-Band Radar (SBX) Placement and Operation, Adak, Alaska

Science.gov (United States)

2005-08-03

Zielinski , Environmental Specialist, EDAW, Inc. B.S., 1984, Biology, University of Alabama in Birmingham Years of Experience: 20 6-2 GMD SBX Placement...Management and Division of Water Permitting Juneau AK Anchorage AK Leroy Phillips Dave Jensen US Army Corps of Engineers The Aleut Corporation Elmendorf AFB AK...Army Corps of Engineers Office of Habitat Management and Elmendorf AFB AK Permitting Anchorage AK Dave Jensen Lari Belisle The Aleut Corporation Federal

77 FR 50914 - Anchorage; Change to Cottonwood Island Anchorage, Columbia River, Oregon and Washington

Science.gov (United States)

2012-08-23

... under Executive Order 13211. 13. Technical Standards The National Technology Transfer and Advancement... of Proposed Rulemaking A. Regulatory History and Information On June 13, 2011, the Coast Guard...'' comprises small businesses, not-for-profit organizations that are independently owned and operated and are...

76 FR 34197 - Anchorage; Change to Cottonwood Island Anchorage, Columbia River, Oregon and Washington

Science.gov (United States)

2011-06-13

... Cottonwood Island in the vicinity of the spoil area to approximately the Kalama North dock and the previous... litigation, eliminate ambiguity, and reduce burden. Protection of Children We have analyzed this proposed rule under Executive Order 13045, Protection of Children from Environmental Health Risks and Safety...

Factors affecting the clinical success of orthodontic anchorage: Experience with 266 temporary anchorage devices

Directory of Open Access Journals (Sweden)

Tai-Ting Lai

2014-03-01

Conclusion: In order to improve the success rates, local inflammation should be monitored and controlled, force application should be 4 weeks after insertion, and the location for placement of TADs should be good quality bone with keratinized mucosa.

Lingual biomechanics, case selection and success

Directory of Open Access Journals (Sweden)

Sanjay Labh

2016-01-01

Full Text Available Deeper understanding of lingual biomechanics is prerequisite for success with lingual appliance. The difference between labial and lingual force system must be understood and kept in mind during treatment planning, especially anchorage planning, and extraction decision-making. As point of application of force changes, it completely changes the force system in all planes. This article describes lingual biomechanics, anchorage planning, diagnostic considerations, treatment planning, and case selection criteria in lingual orthodontics.

Anchorage fatigue. Vermoeiing in verankeringen

Energy Technology Data Exchange (ETDEWEB)

Liemberg, B J

1983-01-01

Modern wind turbines are equipped with slender and slack masts with low eigenfrequency, fastened with anchor bolts to a concrete foundation. As a result of wind loads and the behavior of the turbine these joints are subjected to strongly and irregularly fluctuating forces. This aspect of wind turbine design, mostly somewhat neglected, is investigated by the Sima Stevin laboratory at Delft. Static tests and even normal dynamic tests with loads fluctuating with constant amplitude and frequency are not in accordance with the facts and consequently of limited value. S-N diagrams are made up and discussed. Knowledge of stress concentration lines is necessary for further computations and tests. The case of bolted joints anchored in concrete and under strain of tension (the critical point for these constructions) is elaborated in detail.

33 CFR 110.87 - Henderson Harbor, N.Y.

Science.gov (United States)

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Henderson Harbor, N.Y. 110.87... ANCHORAGE REGULATIONS Special Anchorage Areas § 110.87 Henderson Harbor, N.Y. (a) Area A. The area in the... latitude 43°51′08.8″ N, longitude 76°12′08.9″ W, thence to latitude 43°51′09.0″ N, longitude 76°12′19.0″ W...

Plastic material investment in load-bearing silk attachments in spiders.

Science.gov (United States)

Wolff, Jonas O; Jones, Braxton; Herberstein, Marie E

2018-05-17

The nature and size of attachments is a fundamental element of animal constructions. Presumably, these adhesive structures are plastically deployed to balance material investment and attachment strength. Here we studied plasticity in dragline anchorages of the golden orb web spider, Nephila plumipes. Specifically, we predict that spiders adjust the size and structure of dragline anchorages with load, i.e. spider mass. Mass was manipulated by attaching lead pieces to the spider's abdomen resulting in a 50 percent increase in mass. Loaded spiders spun larger but structurally similar thread anchorages than unloaded spiders. Thus, the spinning program that determines the overall anchor structure is highly stereotypic, and flexibility is introduced through varying the anchor size by increasing material investment. Our study showcases substrate attachments as suitable models to investigate the interplay between innate and changeable elements in the economy of building behaviours. Copyright © 2018 Elsevier GmbH. All rights reserved.

Platelet-rich plasma-an 'Elixir' for treatment of alopecia: personal experience on 117 patients with review of literature.

Science.gov (United States)

Garg, Suruchi; Manchanda, Shweta

2017-01-01

Platelet-rich plasma (PRP) has emerged as a new treatment modality in regenerative plastic surgery and dermatology. PRP is a simple, cost-effective and feasible treatment option with high patient satisfaction for hair loss and can be regarded as a valuable adjuvant treatment modality for androgenic alopecia and other types of non-scarring alopecias. Authors have proposed a hair model termed "Golden anchorage with 'molecular locking' of ectodermal and mesenchymal components for survival and integrity of hair follicle (HF)" in this article. Golden anchorage comprises of bulge stem cells, ectodermal basement membrane and bulge portion of APM. PRP with its autologous supply of millions of growth factors works on 'Golden anchorage' along with keratinocytes (PDGF), dermal papilla (IGF and fibroblast growth factor), vasculature (VEGF and PDGF) and neural cells (Nerve Growth Factor) in a multipronged manner serving as an 'elixir' for hair growth and improving overall environment.

Socket sclerosis--an obstacle for orthodontic space closure?

Science.gov (United States)

Baumgaertel, Sebastian

2009-07-01

Socket sclerosis is a rare reaction to tooth extraction resulting in high-density bone in the center of the alveolar process, where, under normal circumstances, cancellous bone is to be expected. In an adult orthodontic patient, routine extractions of the mandibular first permanent bicuspids were performed, resulting in socket sclerosis and unsuccessful orthodontic space closure. Orthodontic mini-implants were inserted to augment anchorage and aid in space closure. In the presence of socket sclerosis, conventional orthodontic mechanics failed to close the extraction spaces. However, with absolute anchorage in place, space closure occurred at a nearly normal rate. After treatment, no signs of socket sclerosis were discernible on the periapical radiographs. Socket sclerosis can be an obstacle for orthodontic space closure if traditional mechanics are employed. However, mini-implant-reinforced anchorage can lead to successful space closure, resulting in complete resolution of the sclerotic sites.

Use of palatally inserted mini-screw for upper molar distalization: A case series

Directory of Open Access Journals (Sweden)

Valliollah Arash

2015-09-01

Full Text Available  Abstract Reports have shown that molars can be distalized successfully with virtually no orthodontic anchorage loss with an intraosseous anchorage, even with fully erupted second molars. The purpose of this study was evaluating the effects of mini-screws as skeletal anchorage for upper molar distalization. In this case series, three patients needing maxillary first molar distalization, were selected. mini-screw was inserted in the anterior part of the palate. The screws were anchored to the first premolars by transpalatal arch and immediately loaded (150-160 g by 0.018-inch arch-wire and steel open-coil spring to distalize maxillary molars. The skeletal and dental changes were measured on cephalograms obtained before and after distalization. The amount of first molar distalization in the patients was 4 mm with 2°of tipping, 4 mm with 5°of tipping, and 3.5 mm with 2°of tipping respectively. Upper incisors and first premolars were stable during distalization.       

Structural failure modes in vertical tanks: reinforcement evaluation and solutions

International Nuclear Information System (INIS)

Alcantud Abellan, M.; Orden Martinez, A.

1995-01-01

Vertical storage tanks are essential components in the safety of nuclear plant systems. It has been shown that the traditional method of analysing seismic loads is not conservative, as it does not take account of the interaction between fluid and tank structure. This paper identifies different possible structural failure modes in tanks due to seismic load, and methods devised by various authors to evaluate tank structure capacity under different failure modes. These methods are based on experimental data relating to the structural behaviour of tanks during actual seismic events, tests, and theoretical analyses. The paper describes the problems of these structures under seismic loads in nuclear plants. It proposes solutions to the main structural problem, tank anchorage, for which the re-evaluation of the anchorage capacity is required, using methods (finite element) less conservative than those proposed by other authors. Also proposed is the local reinforcement of anchorages to increase their capacity. (Author) 4 refs

Peri-implant evaluation of osseointegrated implants subjected to orthodontic forces: results after three years of functional loading

Directory of Open Access Journals (Sweden)

Bruna de Rezende Marins

2016-04-01

Full Text Available ABSTRACT Objective: The objective of this study was to clinically and radiographically assess the peri-implant conditions of implants used as orthodontic anchorage. Methods: Two groups were studied: 1 a test group in which osseointegrated implants were used as orthodontic anchorage, with the application of 200-cN force; and 2 a control group in which implants were not subjected to orthodontic force, but supported a screw-retained prosthesis. Clinical evaluations were performed three, six and nine months after prosthesis installation and 1- and 3-year follow-up examinations. Intraoral periapical radiographs were obtained 30 days after surgical implant placement, at the time of prosthesis installation, and one, two and three years thereafter. The results were compared by Kruskal-Wallis test. Results: There was no statistically significant difference in clinical probing depth (p = 0.1078 or mesial and distal crestal bone resorption (p = 0.1832 during the study period. After three years of follow-up, the mean probing depth was 2.21 mm for the control group and 2.39 mm for the test group. The implants of the control group showed a mean distance between the bone crest and implant shoulder of 2.39 mm, whereas the implants used as orthodontic anchorage showed a mean distance of 2.58 mm at the distal site. Conclusion: Results suggest that the use of stable intraoral orthodontic anchorage did not compromise the health of peri-implant tissues or the longevity of the implant.

Asymmetry a challenge for orthodontists

DEFF Research Database (Denmark)

Melsen, Birte

2007-01-01

planes of space. A systematic approach to the identification of the cause of the asymmetry head precede the decision whether to correct or to camouflage. The definition of a specific treatment goal should be done only following an analysis of the likelihood that the force system necessary to perform...... the required tooth displacements can be generated. In order to control the interaction between the force systems developed in the three planes of space, the appliances should commonly be segmented. Anchorage problems can occasionally only be solved by means of skeletal anchorage....

A Clinical Evaluation of Three Force Delivery Systems in Stage II of the Begg Technique

Directory of Open Access Journals (Sweden)

Vincy Antony Margaret

2013-01-01

Materials and methods: The present study was designed to compare the rates of retraction and anchorage loss between elastics, elastomeric chains and nickel-titanium (NiTi closed coil springs, using a continuous archwire system with the Begg light wire differential force technique. Results: The rate of canine retraction was faster by 0.6 mm per month with the NiTi closed coil spring compared to elastics and elastomeric chains. The NiTi closed coil springs produced more rapid rate of canine retraction but they also produced the greatest amount of anchorage loss.

Mini-Implants: New Possibilities in Interdisciplinary Treatment Approaches

Directory of Open Access Journals (Sweden)

Biju Sebastian

2014-01-01

Full Text Available The introduction of mini-implants has broadened the range of tooth movements possible by fixed appliance therapy alone. The limits of fixed orthodontic treatment have become more a matter of facial appearance than anchorage. Many complex cases which would previously have required surgery or functional appliances can now be treated with fixed appliance therapy using mini-implants. A mutilated dentition case where mini-implants were used to provide anchorage for intrusion of molars and retraction of anterior teeth is reported here to illustrate this point.

Finite element analysis of the equivalent stress distribution in Schanz screws during the use of a femoral fracture distractor

Directory of Open Access Journals (Sweden)

Vincenzo Giordano

Full Text Available ABSTRACT To evaluate the mechanical stress and elastic deformation exercised in the thread/shaft transition of Schanz screws in assemblies with different screw anchorage distances in the entrance to the bone cortex, through the distribution and location of tension in the samples. An analysis of 3D finite elements was performed to evaluate the distribution of the equivalent stress (triple stress state in a Schanz screw fixed bicortically and orthogonally to a tubular bone, using two mounting patterns: (1 thread/shaft transition located 20 mm from the anchorage of the Schanz screws in the entrance to the bone cortex and (2 thread/shaft transition located 3 mm from the anchorage of the Schanz screws in entrance to the bone cortex. The simulations were performed maintaining the same direction of loading and the same distance from the force vector in relation to the center of the hypothetical bone. The load applied, its direction, and the distance to the center of the bone were constant during the simulations in order to maintain the moment of flexion equally constant. The present calculations demonstrated linear behavior during the experiment. It was found that the model with a distance of 20 mm between the Schanz screws anchorage in the entrance to the bone cortex and the thread/shaft transition reduces the risk of breakage or fatigue of the material during the application of constant static loads; in this model, the maximum forces observed were higher (350 MPa. The distance between the Schanz screws anchorage at the entrance to the bone cortex and the smooth thread/shaft transition of the screws used in a femoral distractor during acute distraction of a fracture must be farther from the entrance to the bone cortex, allowing greater degree of elastic deformation of the material, lower mechanical stress in the thread/shaft transition, and minimized breakage or fatigue. The suggested distance is 20 mm.

Utilização de microparafusos ortodônticos na correção de assimetrias The use of orthodontic microscrews in the asymmetries correction

Directory of Open Access Journals (Sweden)

Henrique Mascarenhas Villela

2008-10-01

Full Text Available INTRODUÇÃO: o controle da ancoragem é de fundamental importância para o sucesso do tratamento ortodôntico, principalmente na correção das assimetrias, onde se torna ainda mais crítico. Os métodos convencionais de ancoragem utilizados para tratar estes tipos de anomalia são mais complexos e podem causar movimentos indesejáveis na unidade de reação ou, ainda, ser rejeitados pelos pacientes, devido ao comprometimento estético. A utilização de microparafusos como unidades de ancoragem, além de anular os efeitos colaterais indesejáveis, simplifica a mecânica ortodôntica, fornece uma maior previsibilidade ao resultado do tratamento, proporciona maior conforto e estética ao paciente, reduz o tempo de tratamento e possibilita a correção de casos com perdas dentárias, já que fornece uma ancoragem direta. OBJETIVO: realizar uma revisão de literatura sobre o tratamento das assimetrias dentárias com o uso de microparafusos ortodônticos de titânio como ancoragem, ilustrando-a com alguns casos clínicos.INTRODUCTION: The control of anchorage is of crucial importance to the success of the orthodontic treatment, specially in the correction of asymmetries, where it plays a most critical role. The conventional anchorage methods used to treat those types of anomaly are more complex and may cause undesirable movements in the reaction unit, or else, be rejected by the patients due to the esthetic involvement. The use of microscrews as anchorage unit not only nullifies the undesirable side effects, but also simplifies the orthodontic mechanics, provides a greater predictability of the treatment outcome, gives the patient more comfort and better esthetic results, shortens the treatment length, and enables the correction of dental loss cases, since it provides direct anchorage. AIM: To carry out a review of the literature on the treatment of dental asymmetries using titanium orthodontic microscrews as anchorage, illustrating it with some

Shear behaviour of reinforced phyllite concrete beams

International Nuclear Information System (INIS)

Adom-Asamoah, Mark; Owusu Afrifa, Russell

2013-01-01

Highlights: ► Phyllite concrete beams often exhibited shear with anchorage bond failure. ► Different shear design provisions for reinforced phyllite beams are compared. ► Predicted shear capacity of phyllite beams must be modified by a reduction factor. -- Abstract: The shear behaviour of concrete beams made from phyllite aggregates subjected to monotonic and cyclic loading is reported. First diagonal shear crack load of beams with and without shear reinforcement was between 42–58% and 42–92% of the failure loads respectively. The phyllite concrete beams without shear links had lower post-diagonal cracking shear resistance compared to corresponding phyllite beams with shear links. As a result of hysteretic energy dissipation, limited cyclic loading affected the stiffness, strength and deformation of the phyllite beams with shear reinforcement. Generally, beams with and without shear reinforcement showed anchorage bond failure in addition to the shear failure due to high stress concentration near the supports. The ACI, BS and EC codes are conservative for the prediction of phyllite concrete beams without shear reinforcement but they all overestimate the shear strength of phyllite concrete beams with shear reinforcement. It is recommended that the predicted shear capacity of phyllite beams reinforced with steel stirrups be modified by a reduction factor of 0.7 in order to specify a high enough safety factor on their ultimate strength. It is also recommended that susceptibility of phyllite concrete beams to undergo anchorage bond failure is averted in design by the provision of greater anchorage lengths than usually permitted.

Reconnecting Alaska: Mexican Movements and the Last Frontier

Directory of Open Access Journals (Sweden)

Sara V. Komarnisky

2012-06-01

Full Text Available This paper discusses the initial findings of on-going research with Mexican migrants and immigrants to Alaska. The paper outlines the historical and on-going connections between Alaska and Mexico and explores how and why those connections have been obscured or ignored. Powerful imaginaries are associated with places: Alaska, and 'the north' more generally, and Latin America, and Mexico specifically. My research shows how interesting things happen when they are brought together through movement. People from Acuitzio del Canje, Michoacán began travelling to Alaska (Anchorage, and elsewhere to work in the 1950s, and movement between Mexico and Alaska has continued across generations since then. Today, many Acuitzences who live in Anchorage maintain a close relationship with friends and family members in Acuitzio, and travel back and forth regularly. However, this movement is obscured by ideological work that makes Alaska seem separate, isolated, wild, and a place where Mexicans are not imagined to be. Mexican movements into Alaska over time disrupt this vision, showing how Alaska is connected to multiple other geographies, and making the US-Mexico border a salient reference point in everyday life in Anchorage. When the South moves into the North, it can make us think about both 'Alaska' and 'Mexico' in different ways. When the US-Mexico border is relocated to Anchorage, if only for a moment, it can elicit a reaction of humour or surprise. Why is that? And what does this have to do with how people actually live in an interconnected place?

241-U-701 new compressor building and instrument air piping analyses

International Nuclear Information System (INIS)

Huang, F.H.

1994-01-01

Building anchorage analysis is performed to qualify the design of the new compressor building foundation given in the ECN ''241-U-701 New Compressor Building.'' Recommendations for some changes in the ECN are made accordingly. Calculations show that the 6-in.-slab is capable of supporting the pipe supports, and that the building foundation, air compressor and dryer anchorage, and electric rack are adequate structurally. Analysis also shows that the instrument air piping and pipe supports for the compressed air system meet the applicable code requirements and are acceptable. The building is for the U-Farm instrument air systems

Modified sliding mechanics in extraction cases with a bidimensional approach.

Science.gov (United States)

Giancotti, Aldo; Greco, Mario

2010-01-01

To illustrate a modified archwire during space closure with anterior anchorage in Bidimensional Tecnique. The archwire used was a .018x.025 SS on the anterior teeth and .018 SS on the lateral and posterior teeth in order to maintain anterior anchorage using torque and uprighting springs as showed in Bidmensional Technique but exerting lighter forces (150 g). The double section archwire resulted to be an effective alternative option to optimize the lateral and posterior sliding mechanics with controlled tipping and by the application of lighter forces. Copyright © 2010 Società Italiana di Ortodonzia SIDO. Published by Elsevier Srl. All rights reserved.

Mini-implant-supported Molar Distalization

Directory of Open Access Journals (Sweden)

Amit Goyal

2012-01-01

Full Text Available Temporary anchorage devices popularly called mini-implants or miniscrews are the latest addition to an orthodontist′s armamentarium. The following case report describes the treatment of a 16-year-old girl with a pleasant profile, moderate crowding and Angle′s Class II molar relationship. Maxillary molar distalization was planned and mini-implants were used to preserve the anterior anchorage. After 13 months of treatment, Class I molar and canine relation was achieved bilaterally and there was no anterior proclination. Thus, mini-implants provide a viable option to the clinician to carry out difficult tooth movements without any side effects.

Development and testing of texture discriminators for the analysis of trabecular bone in proximal femur radiographs

International Nuclear Information System (INIS)

Huber, M. B.; Carballido-Gamio, J.; Fritscher, K.; Schubert, R.; Haenni, M.; Hengg, C.; Majumdar, S.; Link, T. M.

2009-01-01

Purpose: Texture analysis of femur radiographs may serve as a potential low cost technique to predict osteoporotic fracture risk and has received considerable attention in the past years. A further application of this technique may be the measurement of the quality of specific bone compartments to provide useful information for treatment of bone fractures. Two challenges of texture analysis are the selection of the best suitable texture measure and reproducible placement of regions of interest (ROIs). The goal of this in vitro study was to automatically place ROIs in radiographs of proximal femur specimens and to calculate correlations between various different texture analysis methods and the femurs' anchorage strength. Methods: Radiographs were obtained from 14 femoral specimens and bone mineral density (BMD) was measured in the femoral neck. Biomechanical testing was performed to assess the anchorage strength in terms of failure load, breakaway torque, and number of cycles. Images were segmented using a framework that is based on the usage of level sets and statistical in-shape models. Five ROIs were automatically placed in the head, upper and lower neck, trochanteric, and shaft compartment in an atlas subject. All other subjects were registered rigidly, affinely, and nonlinearly, and the resulting transformation was used to map the five ROIs onto the individual femora. Results: In each ROI, texture features were extracted using gray level co-occurence matrices (GLCM), third-order GLCM, morphological gradients (MGs), Minkowski dimensions (MDs), Minkowski functionals (MFs), Gaussian Markov random fields, and scaling index method (SIM). Coefficients of determination for each texture feature with parameters of anchorage strength were computed. In a stepwise multiregression analysis, the most predictive parameters were identified in different models. Texture features were highly correlated with anchorage strength estimated by the failure load of up to R 2 =0.61 (MF

Dissipation of Impact Stress Waves within the Artificial Blasting Damage Zone in the Surrounding Rocks of Deep Roadway

Directory of Open Access Journals (Sweden)

Jianguo Ning

2016-01-01

Full Text Available Artificial explosions are commonly used to prevent rockburst in deep roadways. However, the dissipation of the impact stress wave within the artificial blasting damage zone (ABDZ of the rocks surrounding a deep roadway has not yet been clarified. The surrounding rocks were divided into the elastic zone, blasting damage zone, plastic zone, and anchorage zone in this research. Meanwhile, the ABDZ was divided into the pulverizing area, fractured area, and cracked area from the inside out. Besides, the model of the normal incidence of the impact stress waves in the ABDZ was established; the attenuation coefficient of the amplitude of the impact stress waves was obtained after it passed through the intact rock mass, and ABDZ, to the anchorage zone. In addition, a numerical simulation was used to study the dynamic response of the vertical stress and impact-induced vibration energy in the surrounding rocks. By doing so, the dissipation of the impact stress waves within the ABDZ of the surrounding rocks was revealed. As demonstrated in the field application, the establishment of the ABDZ in the surrounding rocks reduced the effect of the impact-induced vibration energy on the anchorage support system of the roadway.

Application study on the first cable-stayed bridge with CFRP cables in China

Directory of Open Access Journals (Sweden)

Kuihua Mei

2015-08-01

Full Text Available In order to push forward the development of CFRP cable-stayed bridge and accumulate experiences, the study on the application of the first cable-stayed bridge with CFRP cables in China was carried out. The design essentials of main components of the bridge were introduced and its integral performances, including static properties, dynamic properties and seismic response were analyzed using finite element method. A new bond-type anchorage was developed and the processes of fabricating and installing CFRP cables were elaborated. Based on the results of construction simulation, a tension scheme for bridge was propound. During constructing, the stresses and displacement of girder and pylon, as well as the forces and stresses of cables, were tested. The results indicate that all sections of the bridge could meet the requirements of the ultimate bearing capacity and normal service; the performance of the anchorage is good and the stresses in each cable system are similar; the tested values accord well with the calculated values. Further, creep deformation of the resin in anchorages under service load is not obvious. All these results demonstrate that the first application of CFRP cables in the cable-stayed bridge in China is successful.

Targeted traction of impacted teeth with C-tube miniplates.

Science.gov (United States)

Chung, Kyu-Rhim; Kim, Yong; Ahn, Hyo-Won; Lee, Dongjoo; Yang, Dong-Min; Kim, Seong-Hun; Nelson, Gerald

2014-09-01

Orthodontic traction of impacted teeth has typically been performed using full fixed appliance as anchorage against the traction force. This conventional approach can be difficult to apply in the mixed dentition if the partial fixed appliance offers an insufficient anchor unit. In addition, full fixed appliance can induce unwanted movement of adjacent teeth. This clinical report presents 3 cases where impacted teeth were recovered in the mixed or transitional dentition with skeletal anchorage on the opposite arch without full fixed appliance. Instead, intermaxillary traction was used to bring the impacted teeth into position. With this approach, side effects on teeth and periodontal tissues adjacent to the impaction were minimized.

Experience in surveillance of the prestress of concrete reactor vessels in Wylfa nuclear power station

International Nuclear Information System (INIS)

Dawson, P.; Paton, A.A.; Walsh, S.R.

1989-01-01

This paper describes experience gained in the in-service surveillance of the prestressing system for the prestressed concrete reactor vessels (PCRVs) at Wylfa nuclear power station. The paper gives details of results for the prestressing system obtained from the statutory in-service inspection program of the PCRVs. The program includes a detailed examination of a selection of prestressing tendon anchorages, anchorage load checks using a lift-off technique on a one percent sample of tendons and corrosion inspection of samples of prestressing strand and determination of their mechanical properties. The results obtained from the above in-service inspections have shown that the prestressing system continues to function within its design limits

El fondeadero romano de Isla del Moral y el comercio marítimo en la desembocadura del Guadiana = The Roman anchorage at the island of Moral and the maritime trade in the river mouth of Guadiana

Directory of Open Access Journals (Sweden)

Juan Aurelio Pérez Macías

2014-12-01

Full Text Available En este trabajo se presentan los resultados de la prospección arqueológica subacuática llevada a cabo en el Río Carreras (Ayamonte, Huelva, España con motivo de su dragado. La localización de un depósito submarino con abundante material arqueológico de época romana, en especial material anfórico, nos lleva a considerar este hallazgo como los restos de un fondeadero cercano al yacimiento romano situado en la Isla del Moral (Ayamonte. El análisis de este material cerámico nos permite reflexionar sobre la posición de este asentamiento de la desembocadura del río Guadiana en el comercio marítimo de las costas atlánticas hispanas, y su verdadero papel para facilitar los abastecimientos e intercambios con las poblaciones del interior en el tráfico fluvial que aprovecha el tramo navegable de este río hasta Mértola (Portugal.This paper presents the results of underwater archaeological survey carried out at the Río Carreras (Ayamonte, Huelva, SW Spain on the occasion of the dredging of the River Race. The location of an underwater deposit with plenty of Roman archaeological material, especially amphorae, leads us to consider this finding as the remains of a Roman site near the anchorage located in Isla del Moral (Ayamonte. The analysis of the pottery allows us to reflect on the position of the settlement of the Guadiana River in the maritime trade of Atlantic coasts, and its true role in facilitating supplies and exchanges with interior populations in river traffic leveraging the navigable stretch of this river to Mértola (Portugal.

75 FR 423 - Native American Housing Assistance and Self-Determination Reauthorization Act of 2008: Notice of...

Science.gov (United States)

2010-01-05

..., Alaska. Carol Gore, President/CEO, Cook Inlet Housing Authority, Anchorage, Alaska. Blake Kazama..., Tahlequah, Oklahoma. Thomas McGeisey, Executive Director, Seminole Nation Housing Authority, Wewoka...

Root hairs aid soil penetration by anchoring the root surface to pore walls.

Science.gov (United States)

Bengough, A Glyn; Loades, Kenneth; McKenzie, Blair M

2016-02-01

The physical role of root hairs in anchoring the root tip during soil penetration was examined. Experiments using a hairless maize mutant (Zea mays: rth3-3) and its wild-type counterpart measured the anchorage force between the primary root of maize and the soil to determine whether root hairs enabled seedling roots in artificial biopores to penetrate sandy loam soil (dry bulk density 1.0-1.5g cm(-3)). Time-lapse imaging was used to analyse root and seedling displacements in soil adjacent to a transparent Perspex interface. Peak anchorage forces were up to five times greater (2.5N cf. 0.5N) for wild-type roots than for hairless mutants in 1.2g cm(-3) soil. Root hair anchorage enabled better soil penetration for 1.0 or 1.2g cm(-3) soil, but there was no significant advantage of root hairs in the densest soil (1.5g cm(-3)). The anchorage force was insufficient to allow root penetration of the denser soil, probably because of less root hair penetration into pore walls and, consequently, poorer adhesion between the root hairs and the pore walls. Hairless seedlings took 33h to anchor themselves compared with 16h for wild-type roots in 1.2g cm(-3) soil. Caryopses were often pushed several millimetres out of the soil before the roots became anchored and hairless roots often never became anchored securely.The physical role of root hairs in anchoring the root tip may be important in loose seed beds above more compact soil layers and may also assist root tips to emerge from biopores and penetrate the bulk soil. © The Author 2016. Published by Oxford University Press on behalf of the Society for Experimental Biology.

Role of ANC-1 in tethering nuclei to the actin cytoskeleton.

Science.gov (United States)

Starr, Daniel A; Han, Min

2002-10-11

Mutations in anc-1 (nuclear anchorage defective) disrupt the positioning of nuclei and mitochondria in Caenorhabditis elegans. ANC-1 is shown to consist of mostly coiled regions with a nuclear envelope localization domain (called the KASH domain) and an actin-binding domain; this structure was conserved with the Drosophila protein Msp-300 and the mammalian Syne proteins. Antibodies against ANC-1 localized cytoplasmically and were enriched at the nuclear periphery in an UNC-84-dependent manner. Overexpression of the KASH domain or the actin-binding domain caused a dominant negative anchorage defect. Thus, ANC-1 may connect nuclei to the cytoskeleton by interacting with UNC-84 at the nuclear envelope and with actin in the cytoplasm.

Compliant threads maximize spider silk connection strength and toughness

Science.gov (United States)

Meyer, Avery; Pugno, Nicola M.; Cranford, Steven W.

2014-01-01

Millions of years of evolution have adapted spider webs to achieve a range of functionalities, including the well-known capture of prey, with efficient use of material. One feature that has escaped extensive investigation is the silk-on-silk connection joints within spider webs, particularly from a structural mechanics perspective. We report a joint theoretical and computational analysis of an idealized silk-on-silk fibre junction. By modifying the theory of multiple peeling, we quantitatively compare the performance of the system while systematically increasing the rigidity of the anchor thread, by both scaling the stress–strain response and the introduction of an applied pre-strain. The results of our study indicate that compliance is a virtue—the more extensible the anchorage, the tougher and stronger the connection becomes. In consideration of the theoretical model, in comparison with rigid substrates, a compliant anchorage enormously increases the effective adhesion strength (work required to detach), independent of the adhered thread itself, attributed to a nonlinear alignment between thread and anchor (contact peeling angle). The results can direct novel engineering design principles to achieve possible load transfer from compliant fibre-to-fibre anchorages, be they silk-on-silk or another, as-yet undeveloped, system. PMID:25008083

PAK1 is a breast cancer oncogene that coordinately activates MAPK and MET signaling.

Science.gov (United States)

Shrestha, Y; Schafer, E J; Boehm, J S; Thomas, S R; He, F; Du, J; Wang, S; Barretina, J; Weir, B A; Zhao, J J; Polyak, K; Golub, T R; Beroukhim, R; Hahn, W C

2012-07-19

Activating mutations in the RAS family or BRAF frequently occur in many types of human cancers but are rarely detected in breast tumors. However, activation of the RAS-RAF-MEK-ERK MAPK pathway is commonly observed in human breast cancers, suggesting that other genetic alterations lead to activation of this signaling pathway. To identify breast cancer oncogenes that activate the MAPK pathway, we screened a library of human kinases for their ability to induce anchorage-independent growth in a derivative of immortalized human mammary epithelial cells (HMLE). We identified p21-activated kinase 1 (PAK1) as a kinase that permitted HMLE cells to form anchorage-independent colonies. PAK1 is amplified in several human cancer types, including 30--33% of breast tumor samples and cancer cell lines. The kinase activity of PAK1 is necessary for PAK1-induced transformation. Moreover, we show that PAK1 simultaneously activates MAPK and MET signaling; the latter via inhibition of merlin. Disruption of these activities inhibits PAK1-driven anchorage-independent growth. These observations establish PAK1 amplification as an alternative mechanism for MAPK activation in human breast cancer and credential PAK1 as a breast cancer oncogene that coordinately regulates multiple signaling pathways, the cooperation of which leads to malignant transformation.

Comparison of topical and infiltration anesthesia for orthodontic mini-implant placement

Directory of Open Access Journals (Sweden)

Matheus Miotello Valieri

2014-04-01

Full Text Available Objective: To compare the acceptability and effectiveness of topical and infiltration anesthesia for placement of mini-implants used as temporary anchorage devices. Methods: The sample comprised 40 patients, 17 males and 23 females, whose mean age was 26 years old and who were all undergoing orthodontic treatment and in need for anchorage reinforcement. Mini-implants were bilaterally placed in the maxilla of all individuals, with infiltration anesthesia on one side and topical anesthesia on the other. These 40 patients completed two questionnaires, one before and another after mini-implant placement and pain was measured through a visual analog scale (VAS. The data collected were analyzed using descriptive statistics and the measurements of pain were compared by means of the non-parametric test of Mann-Whitney. Results: It was found that 60% of patients felt more comfortable with the use of topical anesthesia for mini-implant placement; 72.5% of patients described the occurrence of pressure during placement of the anchorage device as the most unpleasant sensation of the entire process; 62.5% of patients felt more pain with the use of topical anesthesia. Conclusion: It was concluded that patients had less pain with the use of infiltration anesthesia, and also preferred this type of anesthetic.

Biomechanics Strategies for Space Closure in Deep Overbite

Directory of Open Access Journals (Sweden)

Harryanto Wijaya

2013-07-01

Full Text Available Space closure is an interesting aspect of orthodontic treatment related to principles of biomechanics. It should be tailored individually based on patient’s diagnosis and treatment plan. Understanding the space closure biomechanics basis leads to achieve the desired treatment objective. Overbite deepening and losing posterior anchorage are the two most common unwanted side effects in space closure. Conventionally, correction of overbite must be done before space closure resulted in longer treatment. Application of proper space closure biomechanics strategies is necessary to achieve the desired treatment outcome. This cases report aimed to show the space closure biomechanics strategies that effectively control the overbite as well as posterior anchorage in deep overbite patients without increasing treatment time. Two patients who presented with class II division 1 malocclusion were treated with fixed orthodontic appliance. The primary strategies included extraction space closure on segmented arch that employed two-step space closure, namely single canine retraction simultaneously with incisors intrusion followed by enmasse retraction of four incisors by using differential moment concept. These strategies successfully closed the space, corrected deep overbite and controlled posterior anchorage simultaneously so that the treatment time was shortened. Biomechanics strategies that utilized were effective to achieve the desired treatment outcome.

Development and testing of texture discriminators for the analysis of trabecular bone in proximal femur radiographs

Energy Technology Data Exchange (ETDEWEB)

Huber, M. B.; Carballido-Gamio, J.; Fritscher, K.; Schubert, R.; Haenni, M.; Hengg, C.; Majumdar, S.; Link, T. M. [Department of Radiology and Biomedical Imaging, University of California, 400 Parnassus Avenue, San Francisco, California 94143 (United States); University of Health Sciences, Medical Informatics and Technology, 6060 Hall (Austria); AO Development Institute, 7270 Davos Platz (Switzerland); Medical University Innsbruck, 6020 Innsbruck (Austria); Department of Radiology and Biomedical Imaging, University of California, 400 Parnassus Avenue, San Francisco, California 94143 (United States)

2009-11-15

Purpose: Texture analysis of femur radiographs may serve as a potential low cost technique to predict osteoporotic fracture risk and has received considerable attention in the past years. A further application of this technique may be the measurement of the quality of specific bone compartments to provide useful information for treatment of bone fractures. Two challenges of texture analysis are the selection of the best suitable texture measure and reproducible placement of regions of interest (ROIs). The goal of this in vitro study was to automatically place ROIs in radiographs of proximal femur specimens and to calculate correlations between various different texture analysis methods and the femurs' anchorage strength. Methods: Radiographs were obtained from 14 femoral specimens and bone mineral density (BMD) was measured in the femoral neck. Biomechanical testing was performed to assess the anchorage strength in terms of failure load, breakaway torque, and number of cycles. Images were segmented using a framework that is based on the usage of level sets and statistical in-shape models. Five ROIs were automatically placed in the head, upper and lower neck, trochanteric, and shaft compartment in an atlas subject. All other subjects were registered rigidly, affinely, and nonlinearly, and the resulting transformation was used to map the five ROIs onto the individual femora. Results: In each ROI, texture features were extracted using gray level co-occurence matrices (GLCM), third-order GLCM, morphological gradients (MGs), Minkowski dimensions (MDs), Minkowski functionals (MFs), Gaussian Markov random fields, and scaling index method (SIM). Coefficients of determination for each texture feature with parameters of anchorage strength were computed. In a stepwise multiregression analysis, the most predictive parameters were identified in different models. Texture features were highly correlated with anchorage strength estimated by the failure load of up to R{sup 2

Inelastic seismic behavior of post-installed anchors for nuclear safety related structures: Generation of experimental database

Energy Technology Data Exchange (ETDEWEB)

Mahadik, Vinay, E-mail: vinay.mahadik@iwb.uni-stuttgart.de; Sharma, Akanshu; Hofmann, Jan

2016-02-15

Highlights: • Experiments for evaluating seismic behavior of anchors were performed. • Two undercut anchor products in use in nuclear facilities were considered. • Monotonic tension, shear and cycling tension tests at different crack widths. • Crack cycling tests at constant, in-phase and out-of phase tension loads. • Characteristics for the two anchors as a function of crack width were identified. - Abstract: Post installed (PI) anchors are often employed for connections between concrete structure and components or systems in nuclear power plants (NPP) and related facilities. Standardized practices for nuclear related structures demand stringent criteria, which an anchor has to satisfy in order to qualify for use in NPP related structures. In NPP and related facilities, the structure–component interaction in the event of an earthquake depends on the inelastic behavior of the concrete structure, the component system and also the anchorage system that connects them. For analysis, anchorages are usually assumed to be rigid. Under seismic actions, however, it is known that anchors may undergo significant plastic displacement and strength degradation. Analysis of structure–component interaction under seismic loads calls for numerical models simulating inelastic behavior of anchorage systems. A testing program covering different seismic loading scenarios in a reasonably conservative manner is required to establish a basis for generating numerical models of anchorage systems. Currently there is a general lack of modeling techniques to consider the inelastic behavior of anchorages in structure–component interaction under seismic loads. In this work, in view of establishing a basis for development of numerical models simulating the inelastic behavior of anchors, seismic tests on two different undercut anchors qualified for their use in NPP related structures were carried out. The test program was primarily based on the DIBt-KKW-Leitfaden (2010) guidelines

78 FR 54669 - Exxon Valdez Oil Spill Public Advisory Committee

Science.gov (United States)

2013-09-05

.... ADDRESSES: First floor conference room, Glenn Olds Hall, 4210 University Drive, Anchorage, Alaska. FOR... public. Willie R. Taylor, Director, Office of Environmental Policy and Compliance. [FR Doc. 2013-21569...

77 FR 32978 - Exxon Valdez Oil Spill Trustee Council; Notice of Meeting

Science.gov (United States)

2012-06-04

... Hall Conference Room, 4210 University Drive, Anchorage, Alaska. FOR FURTHER INFORMATION CONTACT... R. Taylor, Director, Office of Environmental Policy and Compliance. [FR Doc. 2012-13380 Filed 6-1-12...

Measuring the democratic anchorage of governance networks

DEFF Research Database (Denmark)

Fotel, Trine; Sørensen, Eva; Torfing, Jacob

There has been a growing debate about the democratic problems and potentials of governance networks among political scientists and public managers. While some claim that governance networks tend to undermine democracy, others argue that they have the potential to improve and strengthen democracy....... This debate is found wanting in two respects. First of all, there has been far too little discussion about what democracy means in relation to pluricentric governance networks. Second, the current debate builds on the assumption that it is possible to give a clear-cut answer to the question of the democratic...... problems and merits of governance networks. This assumption is highly questionable, and prevents a more nuanced assessment of the democratic performance of governance networks. As such, it diverts the focus of attention away from the fact that governance networks may be democratic in some respects...

76 FR 52599 - Anchorage Regulations; Wells, ME

Science.gov (United States)

2011-08-23

... shape in the ``Actions'' column. If you submit your comments by mail or hand delivery, submit them in an... or shapes as per Rule 30 of the Inland Navigation Rules (33 U.S.C. 2030) when at anchor in a special... limited due to depth (less than or equal to 18 feet). Small Entities Under the Regulatory Flexibility Act...

The Role of a Novel Protease NES1 in Breast Cancer

National Research Council Canada - National Science Library

Band, Vimla

2001-01-01

...). IVGG sequence is required for salt bridge formation. Transfection of NESl cDNA into NESl-negative breast cancer cell line suppressed the anchorage-independent growth and tumor formation in nude mice...

76 FR 29640 - Special Local Regulations for Marine Events; Chester River, Chestertown, MD

Science.gov (United States)

2011-05-23

... 200 yards to an anchorage location, embarking and disembarking Tea Party actors by dinghy, and then... reference Datum NAD 1983. (b) Definitions: (1) Coast Guard Patrol Commander means a commissioned, warrant...

76 FR 11961 - Safety Zone, Dredging Operations; Delaware River, Marcus Hook, PA

Science.gov (United States)

2011-03-04

... term ``small entities'' comprises small businesses, not-for-profit organizations that are independently... effect for only a limited period. Vessel traffic will be diverted through the lower end of Anchorage 7 to...

77 FR 52674 - Fisheries of the Exclusive Economic Zone Off Alaska; Groundfish Fisheries in the Bering Sea and...

Science.gov (United States)

2012-08-30

... Dillingham/Katmai room at the Hilton Hotel, 500 West 3rd Street, Anchorage, AK. You may submit comments on... the legal authority, history of the Steller sea lion protection measures, litigation, potential...

The effect of propagation methods on some growth and physiological characteristics of seed- and vegetatively propagated Eucalyptus varieties

CSIR Research Space (South Africa)

Mokotedi, O

2011-11-01

Full Text Available between root characteristics (hydraulics, anchorage efficiency) and above-ground parameters (survival, leaf gas exchange). Cold-tolerant GN clones are planted across low-productivity, high altitude sites in South Africa....

Unilateral maxillary molar distalization with zygoma-gear appliance.

Science.gov (United States)

Kilkis, Dogan; Bayram, Mehmet; Celikoglu, Mevlut; Nur, Metin

2012-08-01

The aim of this study was to present the orthodontic treatment of a 15-year-old boy with a unilateral maxillary molar distalization system, called the zygoma-gear appliance. It consisted of a zygomatic anchorage miniplate, an inner bow, and a Sentalloy closed coil spring (GAC International, Bohemia, NY). A distalizing force of 350 g was used during the distalization period. The unilateral Class II malocclusion was corrected in 5 months with the zygoma-gear appliance. The maxillary left first molar showed distalization of 4 mm with an inclination of 3°. The maxillary premolars moved distally with the help of the transseptal fibers. In addition, there were slight decreases in overjet (-0.5 mm) and maxillary incisor inclination (-1°), indicating no anchorage loss from the zygoma-gear appliance. Preadjusted fixed appliances (0.022 × 0.028-in, MBT system; 3M Unitek, Monrovia, Calif) were placed in both arches to achieve leveling and alignment. After 14 months of unilateral distalization with the zygoma-gear appliance and fixed appliances, Class I molar and canine relationships were established with satisfactory interdigitation of the posterior teeth. Acceptable overjet and overbite were also achieved. This article shows that this new system, the zygoma-gear appliance, can be used for unilateral maxillary molar distalization without anchorage loss. Copyright © 2012 American Association of Orthodontists. Published by Mosby, Inc. All rights reserved.

77 FR 41909 - Safety Zone; Port of Dutch Harbor; Dutch Harbor, AK

Science.gov (United States)

2012-07-17

... are as follows: NORDICA, FENNICA, AIVIQ, TOR VIKING, HARVEY EXPLORER, HARVEY SPIRIT, SISUAQ, AFFINITY..., Commander, Sector Anchorage. [FR Doc. 2012-17223 Filed 7-16-12; 8:45 am] BILLING CODE 9110-04-P ...

75 FR 23244 - North Pacific Fishery Management Council; Public Meeting

Science.gov (United States)

2010-05-03

.... ADDRESSES: The meeting will be held at the Hotel Captain Cook, 939 W 5th Avenue, Anchorage, AK 99501...); Marine Protection Area (MPA) nominations; President's budget and other budget issues, 2010 National SSC...

Exploiting orthologue diversity for systematic detection of gain-of-function phenotypes

Directory of Open Access Journals (Sweden)

Cantarella Daniela

2008-05-01

Full Text Available Abstract Background Systematic search for genes whose gain-of-function by exogenous expression confers an advantage in cell-based selective screenings is a powerful method for unbiased functional exploration of the genome, and has the potential to disclose new targets for cancer therapy. A major limit of this approach resides in the labor-intensive cloning of resistant cells, identification of the integrated genes and validation of their ability to confer a selective advantage. Moreover, the selection has to be drastic and genes conferring a limited advantage are typically missed. Results We developed a new functional screening strategy based on transduction of mammalian cells of a given species with an expression library from another species, followed by one-shot quantitative tracing with DNA microarrays of all library-derived transcripts before and after selection. In this way, exogenous transcripts enriched after selection, and therefore likely to confer resistance, are readily detected. We transduced a retroviral cDNA expression library from mouse testis into human and canine cells, and optimized the use of commercial murine gene expression arrays for species-specific detection of library-derived transcripts. We then conducted a functional screening by growing library-transduced canine MDCK cells in suspension, to enrich for cDNAs conferring anchorage independence. Notably, these cells show partial resistance to loss of anchorage, and the selection can be of limited stringency, compromising approaches based on clonal selection or anyway requiring high stringency. Microarray analysis revealed reproducible enrichment after three weeks of growth on polyhema for seven genes, among which the Hras proto-oncogene and Sox5. When individually transduced into MDCK cells, Sox5 specifically promoted anchorage-independent growth, thereby confirming the validity and specificity of the approach. Conclusion The procedure described here brings substantial

Quantifying the Traction Force of a Single Cell by Aligned Silicon Nanowire Array

KAUST Repository

Li, Zhou; Song, Jinhui; Mantini, Giulia; Lu, Ming-Yen; Fang, Hao; Falconi, Christian; Chen, Lih-Juann; Wang, Zhong Lin

2009-01-01

The physical behaviors of stationary cells, such as the morphology, motility, adhesion, anchorage, invasion and metastasis, are likely to be important for governing their biological characteristics. A change in the physical properties of mammalian

33 CFR 110.195 - Mississippi River below Baton Rouge, LA, including South and Southwest Passes.

Science.gov (United States)

2010-07-01

... designated anchorage (e.g. cargo transfer, tank cleaning, stack blowing, etc.) may be restricted by other... hawsed position, as rigged for sea transits. Deck-mounted cranes, deck booms and stiff legs may be used...

75 FR 17900 - Fisheries of the South Atlantic, Gulf of Mexico, and Caribbean; Southeastern Data, Assessment...

Science.gov (United States)

2010-04-08

.... ADDRESSES: The meeting will be held at the Hotel Captain Cook, 939 West 5th Avenue, Anchorage, AK 99501... assessment scheduling for 2010-2015, and discuss the SEDAR budget, conflict of interest policies, and...

Uqaaqtut Kuuvanmin (Stories of the Upper Kobuk).

Science.gov (United States)

Pulu, Tupou L.; And Others

This elementary language text is designed for children in bilingual Inupiat-English programs in the Alaskan villages of Ambler, Kobuk, Kiana, Noorvik, and Shungnak. It contains twenty-two short passages entitled "Anchorage,""A New…

Interdisciplinary treatment of a patient with multiple missing teeth and periodontitis.

Science.gov (United States)

Ahn, Jae-Chan; Lee, Jae-Hong; Yoon, Joon-Ho; Lee, Ji-Yeon; Kim, Jung-Hoon

2018-02-01

A 49-year-old woman with several missing and periodontically compromised teeth was referred to the orthodontic department of National Health Insurance Service Ilsan Hospital by the periodontic department for interdisciplinary treatment. Multiple posterior teeth had been extracted 10 days earlier. Her chief complaint was crowding of the anterior teeth, and she wanted to improve both esthetics and function. Orthodontic, periodontic, and prosthodontic treatments were undertaken in the proper timing and sequence with an interdisciplinary approach. As a result, improved periodontal health and a stable occlusion and vertical dimension were achieved. Although there were limited teeth and alveolar bone for anchorage, good esthetic and functional treatment results were obtained through the application of temporary anchorage devices and proper biomechanics. Copyright © 2017 American Association of Orthodontists. Published by Elsevier Inc. All rights reserved.

HER-2 as a Progression Factor and Therapeutic Target in Breast Cancer

National Research Council Canada - National Science Library

1999-01-01

...). We had observed previously that upon reduction of llER-2 in MCF-7 cells by ribozyme-targeting estradiol lost its ability to induce anchorage- independent colony formation in soft agar of the tumor cell...

The Role of EMMPRIN in Tumor Angiogenesis and Metastasis

National Research Council Canada - National Science Library

Marieb, Erica

2002-01-01

.... Using a soft agar assay to assess anchorage-independent growth, increased expression of EMMPRIN stimulated 10-fold and 5-fold increases respectively in the number of colonies formed by MDA-MB-436 and MCF-7...

78 FR 47048 - Notice of Availability of Final Environmental Impact Statement (Final EIS)

Science.gov (United States)

2013-08-02

... may be viewed online or during regular business hours at the following locations: 1. Online at www..., Anchorage, AK 99513. Ms. Grey may be contacted during business hours at (907) 271-5453 (telephone) and (907...

Strengthening of non-seismically detailed reinforced concrete beam ...

Indian Academy of Sciences (India)

work and in order to carry the anchorages sufficiently away from the column face ..... Owing to the strengthening application, joint shear stress–strain behaviour was ..... structures (ACI 352R-02), MI: American Concrete Institute, Farmington Hills.

Experimental study on an electrical deicing technology utilizing carbon fiber tape.

Science.gov (United States)

2012-11-01

In cold regions, snow and ice cause serious safety problems to transportation systems. South central Alaska, particularly Anchorage, is susceptible to a number of icing : events due to frequent freeze/thaw cycles in the winter season. Traditionally, ...

Effects of Permafrost and Seasonally Frozen Ground on the Seismic Response of Transportation Infrastructure Sites

Science.gov (United States)

2010-02-01

This interdisciplinary project combined seismic data recorded at bridge sites with computer models to identify how highway bridges built on permanently and seasonally frozen ground behave during an earthquake. Two sites one in Anchorage and one in...

Opposing activities of the Ras and Hippo pathways converge on regulation of YAP protein turnover

DEFF Research Database (Denmark)

Hong, Xin; Nguyen, Thanh Hung; Chen, Qingfeng

2014-01-01

Cancer genomes accumulate numerous genetic and epigenetic modifications. Yet, human cellular transformation can be accomplished by a few genetically defined elements. These elements activate key pathways required to support replicative immortality and anchorage independent growth, a predictor...

76 FR 11978 - Proposed Amendment of Federal Airways; Alaska

Science.gov (United States)

2011-03-04

... Federal airways in Alaska. Due to construction of wind turbines on Fire Island, AK, the Anchorage VOR is... to assign the use of the airspace necessary to ensure the safety of aircraft and the efficient use of...

Inhibition of Estrogen-induced Growth of Breast Cancer by Targeting Mitochondrial Oxidants

National Research Council Canada - National Science Library

Roy, Deodutta; Felty, Quentin; Kunkle, Brian

2008-01-01

...) Anchorage-independent cell growth, and (c) tumor spheroid formation using new 3D HuBiogel bioassay whether estrogen induced conversion of normal cells to transformed cells is inhibited by treatment with antioxidants, over expression of MnSOD...

Titanium alloy vs. stainless steel miniscrews: an in vivo split-mouth study.

Science.gov (United States)

Bollero, P; Di Fazio, V; Pavoni, C; Cordaro, M; Cozza, P; Lione, R

2018-04-01

To compare in vivo Titanium Alloy (TiA) with Stainless Steel (SS) miniscrews Temporary Anchorage Devices (TADs) using removal torque and Scanning Electron Microscopic (SEM) analysis. 15 subjects (6 males and 9 females) who required maximum anchorage were recruited. For each patient, a TiA TAD and a SS TAD with same length and width were implanted following a randomized split-mouth study design. Retraction was carried out with nickel-titanium spring ligated directly from the anterior hooks of the archwire to the TADs to produce 90 to 100 g of force. When no further anchorage supplementation was needed, the TADs were removed. The removal torque values were registered with a digital screwdriver. After removal, the TADs were collected in a fixed solution and examined using SEM and X-ray microanalysis. All TADs remained intact, with a 100% success rate. There was no difference in removal torque between TiA and SS miniscrews (4.4 ± 1.3 N-cm and 5.1 ± 0.7 N-cm, respectively). All specimens' loss of gloss with signs of biological contaminations resulted in a dull implant surface. SEM photomicrographs of TiA miniscrews showed predominantly blood cells while SS miniscrews showed the precipitation of an amorphous layer with low cellular component. There was no difference in spectroscopic analysis between TiA and SS miniscrews. TiA and SS miniscrews had comparable removal torque values. SEM photomicrographs showed no evidence of osseointegration with both TADs having similar biological responses.

Loss of tumorigenic potential by human lung tumor cells in the presence of antisense RNA specific to the ectopically synthesized alpha subunit of human chorionic gonadotropin.

Science.gov (United States)

Rivera, R T; Pasion, S G; Wong, D T; Fei, Y B; Biswas, D K

1989-06-01

A clonal strain of human lung tumor cells in culture (ChaGo), derived from a bronchogenic carcinoma, synthesizes and secretes large amounts of alpha (alpha) and a comparatively lower level of beta (beta) subunit of the glycoprotein hormone, human chorionic gonadotropin (HCG). ChaGo cells lost their characteristic anchorage-independent growth phenotype in the presence of anti-alpha-HCG antibody. The effect of the antibody was partially reversed by addition of alpha-HCG to the culture medium. ChaGo cells were transfected with an expression vector (pRSV-anti-alpha-HCG), that directs synthesis of RNA complementary to alpha-HCG mRNA. The transfectants produced alpha-HCG antisense RNA which was associated with the reduced level of alpha-HCG. Transfectants also displayed several altered phenotypic properties, including altered morphology, less mitosis, reduced growth rate, loss of anchorage-independent growth, and loss of tumorigenicity in nude mice. Treatment of transfectants with 8,bromo-cAMP resulted in increased accumulation of alpha-HCG mRNA, no change in the level of alpha-HCG antisense RNA, release of the inhibition of [3H]thymidine incorporation, and restoration of anchorage-independent growth phenotype. The overexpression of c-myc, observed in ChaGo cells, was unaffected by the reduced level of alpha-HCG. These results suggest that ectopic synthesis of the alpha subunit of HCG plays a functional role in the transformation of these human lung cells.

Comparison of canine retraction using single and Siamese edgewise brackets: An in vivo study

Directory of Open Access Journals (Sweden)

Zeeshan Iqbal Bhat

2013-01-01

Full Text Available Objectives: The purpose of this study was to check the rate of canine retraction with bodily mechanics using two different pre-adjusted edgewise bracket Systems. Materials and Methods: A split mouth study with twenty patients who were randomly selected and allotted to a single operator. Duration of canine retraction, angulation of canine during its retraction, degree of Rotation, anchorage Loss, distance between canine and premolar at different time intervals were then evaluated, pre- (To, 3 months- (T1 and canine tip touches the second premolar- (T2. Descriptive statistics including mean values and standard deviations were calculated. Paired and unpaired t-test was performed to evaluate the differences between the groups. Results: Rotation and angulation of the canines did not show significant difference in both the systems. There was statistically significant difference (P<0.01 in anchorage loss between single wing and Siamese bracket being 2.65 ±1.41 mm and 1.31 ± 0.93 respectively. There was statistically significant intergroup difference (P<0.01 in canine movement i.e distance between canine and premolar was recorded as 4.72mm (15.06 ± 1.69 to 10.34 ± 1.68mm in single wing bracket and 6.25mm in Siamese (15.52 ± 1.41 to 9.27 ± 1.94. Conclusion: In cases where high anchorage is required and the rate of canine retraction is a concern, Siamese brackets pose a definite advantage over Single wing brackets.

78 FR 69844 - Alaska Village Electric Cooperative, Inc.; Notice of Application Tendered for Filing With the...

Science.gov (United States)

2013-11-21

... CEO, AVEC, 4831 Eagle Street, Anchorage, AK 99503; Telephone (907) 561-1818. i. FERC Contact: Mary... system in Old Harbor. Transmission Line A 6,500-foot-long, 12.47-kV, 3-phase overhead power line will be...

77 FR 41777 - Jacob Focht; Notice of Declaration of Intention and Soliciting Comments, Protests, and/or Motions...

Science.gov (United States)

2012-07-16

... 23(b)(1) of the Federal Power Act, 16 U.S.C. 817(b). h. Applicant Contact: Troy Hardwick, H & K Energy Solutions LLC, P.O. Box 90961, Anchorage, AK 99509; telephone: (907) 301-1641; email: www.troy...

Up to 10-year follow-up of the Symax stem in THA

DEFF Research Database (Denmark)

Edwards, Nina M; Varnum, Claus; Kjærsgaard-Andersen, Per

2018-01-01

INTRODUCTION: The design of the cementless Symax-HA femoral stem is based on geometrical analysis of human femoral anatomy to optimise the fit within the femur. The stem combines an anatomical proximal section enabling a metaphyseal anchorage with a straight distal section. This results in an imp......INTRODUCTION: The design of the cementless Symax-HA femoral stem is based on geometrical analysis of human femoral anatomy to optimise the fit within the femur. The stem combines an anatomical proximal section enabling a metaphyseal anchorage with a straight distal section. This results...... with results from a single centre, Vejle Hospital. From the Danish Hip Arthroplasty Registry, we identified all THAs operated with the Symax stem. The primary outcome was revision. The secondary outcomes were aseptic loosening, periprosthetic fracture, and all other causes for revision. RESULTS: In total, 1...

A Speedy Yet Simple Tip to Align Imbricated Anterior Teeth.

Science.gov (United States)

Saklecha, Bhuwan; Tekale, Pawankumar Dnyandeo; Sonawane, Shivprasad V; Shah, Pratik Rajesh; Patil, Harshal Ashok

2017-05-01

Correction of dental crowding can be achieved with several orthodontic procedures like extraction of teeth, proximal stripping etc. In contemporary orthodontic practice, resolution of incisor crowding is most commonly achieved by the use of canine lacebacks. This method takes time, requires frequent activations and taxes anchorage since it involves the "PULL" mechanics. In order to overcome these disadvantages, mostly the time factor, we devised a method of using open coil NiTi spring on 0.016" SS wire piggy backed on the 0.014" heat activated NiTi base arch wire ligated only at the canines. This method, resolved the incisor crowding in almost one third of the time taken with the use of canine lacebacks. Moreover, the result was more physiologic since light continuous force was applied with the spring and it essentially eliminated the anchorage loss since it involved "PUSH" mechanics.

Improving the cell affinity of a poly(D,L-lactide) film modified by grafting collagen via a plasma technique

International Nuclear Information System (INIS)

Zhao Jianhao; Wang Jue; Tu Mei; Luo Binghong; Zhou Changren

2006-01-01

Poly(D,L-lactide) films were surface-modified by grafting collagen via NH 3 plasma to improve cell affinity. The modified films were characterized by IR analysis, contact angle measurement, SEM analysis and collagen quantity determination. It was demonstrated that -NH 2 and collagen were incorporated into the surface of PDLLA films. The hydrophilicity of the PDLLA film increased after NH 3 plasma treatment, but decreased with further collagen modification. More collagen was incorporated into the PDLLA films by a grating method as compared to that with an anchorage treatment. L929 fibroblast cells were used to evaluate the cell affinity of the modified films and control. It was shown that PDLLA films surface-modified by grafting collagen via NH 3 plasma more efficiently enhanced the cells attachment and proliferation than those films modified by collagen anchorage or only NH 3 plasma treatment

Prosthetic considerations for orthodontic implant site development in the adult patient.

Science.gov (United States)

Holst, Alexandra I; Nkenke, Emeka; Blatz, Markus B; Geiselhöringer, Hans; Holst, Stefan

2009-11-01

Proper site development is a key factor for long-term clinical success of dental implants. Whereas surgical and restorative techniques have been refined to ensure predictable functional and esthetic outcome, individual clinical prerequisites do not always allow proper placement of implants when prosthetic and material properties are considered. Orthodontic tooth movement may be a viable and nonsurgical site development treatment option. With the introduction and advancements of minimal invasive and less visible orthodontic appliances, a growing number of adult patients are willing to obtain orthodontic treatment. The spectrum of modern appliances is broad and ranges from clear aligners to lingual brackets. Skeletal anchorage devices such as orthodontic mini-implants often eliminate unpopular external anchorage devices (ie, headgear) in adult patients, This article discusses the selection of an appropriate pretreatment approach by taking patient-specific criteria into account.

75 FR 17760 - Endangered and Threatened Wildlife and Plants; Spectacled Eider (Somateria fischeri): Initiation...

Science.gov (United States)

2010-04-07

... 94- 98 percent between the early 1970s and the 1993 listing date, from 47,700-70,000 nesting pairs to.... Fish and Wildlife Service, MS-361, 1011 E. Tudor Road, Anchorage, AK 99503. In-Person drop-off or...

75 FR 12536 - City of Tenakee Springs; Notice of Declaration of Intention and Soliciting Comments, Protests...

Science.gov (United States)

2010-03-16

.... 47 S, R. 63 E, secs. 15, 21, and 22, Copper River Meridian. g. Filed Pursuant to: Section 23(b)(1) of..., Anchorage, AK 99503; telephone: (907) 258-2420; FAX: (907) 258-2419; e- mail: [email protected] . i...

Civil Division - Alaska Department of Law

Science.gov (United States)

Attorney General Opinions Executive Branch Ethics Criminal Justice Alaska Medicaid Fraud Control Anchorage department and other agencies on the management, retention, communication, and disclosure of information matters. In addition, the legislative liaison coordinates responses to media requests. Natural Resources

75 FR 76275 - Anchorage Regulations; Long Island Sound

Science.gov (United States)

2010-12-08

... tailored to the safety purpose of that notification requirement. In paragraph (b)(4), for the convenience... standards (e.g., specifications of materials, performance, design, or operation; test methods; sampling...

"Dinosaurs." Kindergarten. Anchorage School District Elementary Science Program.

Science.gov (United States)

Herminghaus, Trisha, Ed.

This unit contains 15 lessons on dinosaurs for kindergarten children. It provides a materials list, supplementary materials list, use of process skill terminology, unit objectives, vocabulary, six major dinosaurs, and background information. Lessons are: (1) "Webbing"; (2) "Introduction to the Big Six"; (3) "Paleontology…

78 FR 42757 - Marine Mammals; File No. 17411

Science.gov (United States)

2013-07-17

... DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration RIN 0648-XC541 Marine Mammals; File No. 17411 AGENCY: National Marine Fisheries Service (NMFS), National Oceanic and Atmospheric... permit has been issued to Dr. Jennifer Burns, University of Alaska Anchorage, Biology Department...

Mini-implants in orthodontics: A systematic review of the literature

NARCIS (Netherlands)

Reynders, Reint; Ronchi, Laura; Bipat, Shandra

2009-01-01

Introduction: In this article, we systematically reviewed the literature to quantify success and complications encountered with the use of mini-implants for orthodontic anchorage, and to analyze factors associated with success or failure. Methods: Computerized and manual searches were conducted up

Sadhana | Indian Academy of Sciences

Indian Academy of Sciences (India)

Damage detection in submerged plates using ultrasonic guided waves ... Information extraction from topographic map using colour and shape analysis ... Mathematical modelling on transport of petroleum hydrocarbons in saturated ... Proper reinforcement anchorage is essential to enhance the performance of the joints.

75 FR 52385 - Office of Hazardous Materials Safety; Actions on Special Permit Applications

Science.gov (United States)

2010-08-25

... communication requirements, quantity limitations and certain loading and stowage requirements (mode 4). Nature... Dog 172.101 Column transportation in Operations, 9(B). commerce of Anchorage, AK. Xanthates, which... subject to hazard communication requirements, quantity limitations and certain loading and stowage...

Quantitative analysis on orientation of human bone integrated with midpalatal implant by micro X-ray diffractometer

International Nuclear Information System (INIS)

Murata, Masaru; Akazawa, Toshiyuki; Yuasa, Toshihiro; Okayama, Miki; Tazaki, Junichi; Hanawa, Takao; Arisue, Makoto; Mizoguchi, Itaru

2012-01-01

Highlights: ► A titanium fixture is implanted into palatal bone of an 18-year-old patient as the unmoved anchorage for the orthodontic treatment. ► The fixture is integrated with compact bone with cortical bone-like osteon. ► Microbeam X-ray diffraction denotes the crystallinity and orientation of HAp. ► X-ray images of c-face in HAp reveal functionally graded distribution of bone quality. ► The crystal growth of c-face is caused by propagation of the continuous lateral stress. - Abstract: A midpalatal implant system has been used as the unmoved anchorage for teeth movement. An 18-year-old male patient presented with reversed occlusion and was diagnosed as malocclusion. A pure titanium fixture (lengths: 4 mm, diameter: 3.3 mm, Orthosystem ® , Institute Straumann, Switzerland) was implanted into the palatal bone of the patient as the orthodontic anchorage. The implant anchorage was connected with the upper left and right first molars, and had been used for 3 years. After dynamic treatments, the titanium fixture connected with bone was removed surgically, fixed in formalin solution, and embedded in resin. Specimens were cut along the frontal section of face and the direction of longitudinal axis of the implant, stained, and observed histologically. The titanium fixture was integrated directly with compact bone showing cortical bone-like structure such as lamella and osteon. In addition, to qualitatively characterize the implant-supported human bone, the crystallinity and orientation of hydroxyapatite (HAp) phase were evaluated by the microbeam X-ray diffraction analysis. Preferential alignment of c-axis of HAp crystals was represented by the relative intensity ratio of (0 0 2)-face diffraction peak to (3 1 0)-face one. The values decreased monotonously along the direction of the lateral stress from the site near the implant thread to the distant site in all horizontal lines of the map. These results indicated that the X-ray images for the intensity of c

Quantitative analysis on orientation of human bone integrated with midpalatal implant by micro X-ray diffractometer

Energy Technology Data Exchange (ETDEWEB)

Murata, Masaru, E-mail: murata@hoku-iryo-u.ac.jp [Health Sciences University of Hokkaido, 1757 Kanazawa, Tobetsu-cho 061-0293 (Japan); Akazawa, Toshiyuki [Hokkaido Research Organization, Nishi-11, Kita-19, Kita-ku, Sapporo 060-0819 (Japan); Yuasa, Toshihiro; Okayama, Miki; Tazaki, Junichi [Health Sciences University of Hokkaido, 1757 Kanazawa, Tobetsu-cho 061-0293 (Japan); Hanawa, Takao [Tokyo Medical and Dental University, 2-3-10 Kandasurugadai, Chiyoda-ku, Tokyo 101-0062 (Japan); Arisue, Makoto; Mizoguchi, Itaru [Health Sciences University of Hokkaido, 1757 Kanazawa, Tobetsu-cho 061-0293 (Japan)

2012-12-01

Highlights: Black-Right-Pointing-Pointer A titanium fixture is implanted into palatal bone of an 18-year-old patient as the unmoved anchorage for the orthodontic treatment. Black-Right-Pointing-Pointer The fixture is integrated with compact bone with cortical bone-like osteon. Black-Right-Pointing-Pointer Microbeam X-ray diffraction denotes the crystallinity and orientation of HAp. Black-Right-Pointing-Pointer X-ray images of c-face in HAp reveal functionally graded distribution of bone quality. Black-Right-Pointing-Pointer The crystal growth of c-face is caused by propagation of the continuous lateral stress. - Abstract: A midpalatal implant system has been used as the unmoved anchorage for teeth movement. An 18-year-old male patient presented with reversed occlusion and was diagnosed as malocclusion. A pure titanium fixture (lengths: 4 mm, diameter: 3.3 mm, Orthosystem{sup Registered-Sign }, Institute Straumann, Switzerland) was implanted into the palatal bone of the patient as the orthodontic anchorage. The implant anchorage was connected with the upper left and right first molars, and had been used for 3 years. After dynamic treatments, the titanium fixture connected with bone was removed surgically, fixed in formalin solution, and embedded in resin. Specimens were cut along the frontal section of face and the direction of longitudinal axis of the implant, stained, and observed histologically. The titanium fixture was integrated directly with compact bone showing cortical bone-like structure such as lamella and osteon. In addition, to qualitatively characterize the implant-supported human bone, the crystallinity and orientation of hydroxyapatite (HAp) phase were evaluated by the microbeam X-ray diffraction analysis. Preferential alignment of c-axis of HAp crystals was represented by the relative intensity ratio of (0 0 2)-face diffraction peak to (3 1 0)-face one. The values decreased monotonously along the direction of the lateral stress from the site near the

76 FR 77887 - Notice of Passenger Facility Charge (PFC) Approvals and Disapprovals

Science.gov (United States)

2011-12-14

... mounted snow plow blade Service road rehabilitation Acquire aircraft rescue and firefighting fire suits..., Anchorage, AK 11/04/11 22,000,000 21,043,173 01/01/06 01/01/06 06-17-C-01-ORD, Chicago, IL 11/08/11 73,198...

75 FR 39910 - Prince William Sound Resource Advisory Committee; Meeting

Science.gov (United States)

2010-07-13

... DEPARTMENT OF AGRICULTURE Forest Service Prince William Sound Resource Advisory Committee; Meeting AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Prince William Sound Resource..., Anchorage, Alaska 99503. Send written comments to Prince William Sound Resource Advisory Committee, c/o USDA...

Emerging boundaries

DEFF Research Database (Denmark)

Løvschal, Mette

2014-01-01

of temporal and material variables have been applied as a means of exploring the processes leading to their socioconceptual anchorage. The outcome of this analysis is a series of interrelated, generative boundary principles, including boundaries as markers, articulations, process-related devices, and fixation...

Is the pull-out force of the Meniscus Arrow in bone affected by the inward curling of the barbs during biodegradation? An in vitro study

NARCIS (Netherlands)

Wouters, Diederick B.; Burgerhof, Johannes G. M.; de Hosson, Jeff T. M.; Bos, Rudolf R. M.

Background: Inward curling of the barbs of Meniscus Arrows during degradation was observed in a previous study, in which swelling, distention, and water uptake by Meniscus Arrows was evaluated. This change of configuration could have consequences with respect to anchorage capacity in bone.

Actomyosin organisation for adhesion, spreading, growth and movement in chick fibroblasts

DEFF Research Database (Denmark)

Couchman, J R; Rees, D A

1979-01-01

for anchorage-dependent growth, rather than facilitate their movement. The fibroblasts specialized for movement from the explants, though equally well spread, make contact with substratum through extensive areas of relatively unspecialized membrane, have less well developed stress fibres and a low growth rate....

29 CFR 1601.74 - Designated and notice agencies.

Science.gov (United States)

2010-07-01

... Human Relations law to include charges of retaliation. Therefore, retaliation charges will be deferred... agencies are: Alaska Commission for Human Rights Alexandria (VA) Human Rights Office Allentown (PA) Human Relations Commission Anchorage (AK) Equal Rights Commission Anderson (IN) Human Relations Commission Arizona...

[Effects of ezrin silencing on pancreatic cancer cell line Panc-1].

Science.gov (United States)

Meng, Yun-xiao; Yu, Shuang-ni; Lu, Zhao-hui; Chen, Jie

2012-12-01

To explore the effects of ezrin silencing on pancreatic cancer cell line Panc-1. Pancreatic cancer cell line Panc-1 was transfected with ezrin silencing plasmid. The proliferation and the cell cycle status were determined by CCK-8 assay and flow cytometry analysis, respectively. Cellular membrane protrusions/microvilli formation were visualized by scanning election microscopy. Colony formation assay was used to determine the cell anchor-independent growth ability in vitro. Trans-filter migration and invasion assays were performed with 8 µm pore inserts in a 24-well BioCoat chamber with/without Matrigel. Ezrin silencing decreased cellular protrusions/microvilli formation, anchorage-independent growth, cell migration and invasion, but had no effects on cell proliferation in vitro and cell cycle, in pancreatic cancer cell line Panc-1. Ezrin expression affects the cellular protrusions/microvilli formation, anchorage-independent growth, cell migration and invasion in pancreatic cancer cell line Panc-1.

Lower limit of strength wedge-type anchor bolts

International Nuclear Information System (INIS)

Arnedo Pena, A.; Frances Urmeneta, M.

1998-01-01

Simple expansion bolts, with a split expansion ring and a threaded bolt with an integral cone expander, called wedge type, are very used in securing and anchoring structures. The anchorage is obtained by a mechanism of torque-controlled expansion. Although less resistant than other types, its easy installation and low cost make them very competitive in light structures. In this paper, the minimum capacity values are analysed, when they are used to anchor safety-related equipment in NPP. The EPRI criteria developed in response to USI A-46 are applied and complemented by the new CEB Anchorage Design Guide. The results are compared with the information from european manufactures, adopting different safety factors for cracked and non-cracked concrete. With adequate control and inspection measures, including areas of noticeable cracking of concrete. minimum values for equipment can be obtained satisfying the strictest seismic validation requirements. (Author) 5 refs

Redefining orthodontic space closure: sequential repetitive loading of the periodontal ligament--a clinical study.

Science.gov (United States)

Kalha, Anmol S; Kachiwala, Viral Ashok; Govardhan, Singatagere Nagaraj; McLaughlin, Richard P; Khurshaid, Syed Zameer

2010-01-01

To assess the rate of tooth movement, anchorage loss, root resorption, and alkaline phosphatase (ALP) activity in the gingival crevicular fluid (GCF) as a marker for bone remodeling during orthodontic space closure using two different mechanisms. Space closure was completed in 20 patients with extraction of all 4 premolars. Lateral cephalograms and radio-visiographs taken before (T1) and after (T2) space closure were assessed for anchorage loss and root resorption. Alkaline phosphatase levels were measured in 10 patients, which were divided into two groups of five each. Spaces were closed with a screw device in the first group and with active tie-backs in the second. Gingival crevicular fluid samples, collected at intervals, were assayed for alkaline phosphatase spectrophotometrically in each patient. The mean rate of tooth movement was 1.32 ± 0.22 mm/month. The mean amount of anchorage loss in the maxilla and mandible was 1.23 ± 0.60 mm and 1.08 ± 0.65 mm, respectively. Sixty (25%) roots showed no root resorption, while 180 (75%) roots displayed mild to moderate blunting of their apices. Gingival crevicular fluid-alkaline phosphatase level increased significantly from day 7 to day 28 in both groups, but significantly more in the screw retraction group (Pspace closure occurs more rapidly with sequential repetitive loading of the periodontal ligament than with conventional active tie-backs. This observation is in concurrence with a significant increase in the gingival crevicular fluid-alkaline phosphatase level. © 2010 BY QUINTESSENCE PUBLISHING CO, INC.

The Effect of Using Self-ligating Brackets on Maxillary Canine Retraction: A Split-mouth Design Randomized Controlled Trial.

Science.gov (United States)

Hassan, Siba E; Hajeer, Mohammad Y; Alali, Osama H; Kaddah, Ayham S

2016-06-01

The results of previous studies about the efficacy of using self-ligating brackets (SLBs) in controlling canine movement during retraction are not in harmony. Therefore, the current study aimed to compare the effects of using new passive SLBs on maxillary canine retraction with sliding mechanics vs conventional ligating brackets (CLBs) tied with metal ligatures. The sample comprised 15 adult patients (4 males, 11 females; 18-24 years) requiring bilateral extraction of maxillary first premolars. Units of randomization are the left or right maxillary canines within the same patient. The two maxillary canines in each patient were randomly assigned to one of the two groups in a simple split-mouth design. The canines in the SLBs group (n = 15) were bracketed with SLBs (Damon Q™), while the canines in the CLBs group (n = 15) were bracketed with conventional brackets (Mini Master Series). Transpalatal bars were used for anchorage. After leveling and alignment, 0.019 × 0.025" stainless steel working archwires were placed. Canines were retracted using a nickel-titanium close-coil springs with a 150 gm force. The amount and rate of maxillary canine retraction, canine rotation, and loss of anchorage were measured on study models collected at the beginning of canine retraction (T0) and 12 weeks later (T1). Differences were analyzed using paired-samples t-tests. The effect differences were statistically significant (p brackets gave better results compared to the CLBs in terms of rate of movement, amount of canine rotation following extraction, and anchorage loss.

Enhanced carcinogenicity by coexposure to arsenic and iron and a novel remediation system for the elements in well drinking water.

Science.gov (United States)

Kumasaka, Mayuko Y; Yamanoshita, Osamu; Shimizu, Shingo; Ohnuma, Shoko; Furuta, Akio; Yajima, Ichiro; Nizam, Saika; Khalequzzaman, Md; Shekhar, Hossain U; Nakajima, Tamie; Kato, Masashi

2013-03-01

Various carcinomas including skin cancer are explosively increasing in arsenicosis patients who drink arsenic-polluted well water, especially in Bangladesh. Although well drinking water in the cancer-prone areas contains various elements, very little is known about the effects of elements except arsenic on carcinogenicity. In order to clarify the carcinogenic effects of coexposure to arsenic and iron, anchorage-independent growth and invasion in human untransformed HaCaT and transformed A431 keratinocytes were examined. Since the mean ratio of arsenic and iron in well water was 1:10 in cancer-prone areas of Bangladesh, effects of 1 μM arsenic and 10 μM iron were investigated. Iron synergistically promoted arsenic-mediated anchorage-independent growth in untransformed and transformed keratinocytes. Iron additionally increased invasion in both types of keratinocytes. Activities of c-SRC and ERK that regulate anchorage-independent growth and invasion were synergistically enhanced in both types of keratinocytes. Our results suggest that iron promotes arsenic-mediated transformation of untransformed keratinocytes and progression of transformed keratinocytes. We then developed a low-cost and high-performance adsorbent composed of a hydrotalcite-like compound for arsenic and iron. The adsorbent rapidly reduced concentrations of both elements from well drinking water in cancer-prone areas of Bangladesh to levels less than those in WHO health-based guidelines for drinking water. Thus, we not only demonstrated for the first time increased carcinogenicity by coexposure to arsenic and iron but also proposed a novel remediation system for well drinking water.

Nonlinear analysis of pre-stressed concrete containment vessel (PCCV) using the damage plasticity model

Energy Technology Data Exchange (ETDEWEB)

Shokoohfar, Ahmad; Rahai, Alireza, E-mail: rahai@aut.ac.ir

2016-03-15

Highlights: • This paper describes nonlinear analyses of a 1:4 scale model of a (PCCV). • Coupled temp-disp. analysis and concrete damage plasticity are considered. • Temperature has limited effects on correct failure mode estimation. • Higher pre-stressing forces have limited effects on ultimate radial displacements. • Anchorage details of liner plates leads to prediction of correct failure mode. - Abstract: This paper describes the nonlinear analyses of a 1:4 scale model of a pre-stressed concrete containment vessel (PCCV). The analyses are performed under pressure and high temperature effects with considering anchorage details of liner plate. The temperature-time history of the model test is considered as an input boundary condition in the coupled temp-displacement analysis. The constitutive model developed by Chang and Mander (1994) is adopted in the model as the basis for the concrete stress–strain relation. To trace the crack pattern of the PCCV concrete faces, the concrete damage plasticity model is applied. This study includes the results of the thermal and mechanical behaviors of the PCCV subject to temperature loading and internal pressure at the same time. The test results are compared with the analysis results. The analysis results show that the temperature has little impact on the ultimate pressure capacity of the PCCV. To simulate the exact failure mode of the PCCV, the anchorage details of the liner plates around openings should be maintained in the analytical models. Also the failure mode of the PCCV structure hasn’t influenced by hoop tendons pre-stressing force variations.

The eukaryotic translation elongation factor eEF1A2 induces neoplastic properties and mediates tumorigenic effects of ZNF217 in precursor cells of human ovarian carcinomas

Energy Technology Data Exchange (ETDEWEB)

Sun, Yu; Wong, Nicholas; Guan, Yinghui; Salamanca, Clara M.; Cheng, Jung Chien; Lee, Jonathan M.; Gray, Joe W.; Auersperg, Nelly

2008-04-25

Ovarian epithelial carcinomas (OEC) frequently exhibit amplifications at the 20q13 locus which is the site of several oncogenes, including the eukaryotic elongation factor EEF1A2 and the transcription factor ZNF217. We reported previously that overexpressed ZNF217 induces neoplastic characteristics in precursor cells of OEC. Unexpectedly, ZNF217, which is a transcriptional repressor, enhanced expression of eEF1A2. In this study, array comparative genomic hybridization, single nucleotide polymorphism and Affymetrix analysis of ZNF217-overexpressing cell lines confirmed consistently increased expression of eEF1A2 but not of other oncogenes, and revealed early changes in EEF1A2 gene copy numbers and increased expression at crisis during immortalization. We defined the influence of eEF1A2 overexpression on immortalized ovarian surface epithelial cells, and investigated interrelationships between effects of ZNF217 and eEF1A2 on cellular phenotypes. Lentivirally induced eEF1A2 overexpression caused delayed crisis, apoptosis resistance and increases in serum-independence, saturation densities, and anchorage independence. siRNA to eEF1A2 reversed apoptosis resistance and reduced anchorage independence in eEF1A2-overexpressing lines. Remarkably, siRNA to eEF1A2 was equally efficient in inhibiting both anchorage independence and resistance to apoptosis conferred by ZNF217 overexpression. Our data define neoplastic properties that are caused by eEF1A2 in nontumorigenic ovarian cancer precursor cells, and suggest that eEF1A2 plays a role in mediating ZNF217-induced neoplastic progression.

Mitochondrial clearance by the STK38 kinase supports oncogenic Ras-induced cell transformation

Science.gov (United States)

Bettoun, Audrey; Surdez, Didier; Vallerand, David; Gundogdu, Ramazan; Sharif, Ahmad A.D.; Gomez, Marta; Cascone, Ilaria; Meunier, Brigitte; White, Michael A.; Codogno, Patrice; Parrini, Maria Carla; Camonis, Jacques H.; Hergovich, Alexander

2016-01-01

Oncogenic Ras signalling occurs frequently in many human cancers. However, no effective targeted therapies are currently available to treat patients suffering from Ras-driven tumours. Therefore, it is imperative to identify downstream effectors of Ras signalling that potentially represent promising new therapeutic options. Particularly, considering that autophagy inhibition can impair the survival of Ras-transformed cells in tissue culture and mouse models, an understanding of factors regulating the balance between autophagy and apoptosis in Ras-transformed human cells is needed. Here, we report critical roles of the STK38 protein kinase in oncogenic Ras transformation. STK38 knockdown impaired anoikis resistance, anchorage-independent soft agar growth, and in vivo xenograft growth of Ras-transformed human cells. Mechanistically, STK38 supports Ras-driven transformation through promoting detachment-induced autophagy. Even more importantly, upon cell detachment STK38 is required to sustain the removal of damaged mitochondria by mitophagy, a selective autophagic process, to prevent excessive mitochondrial reactive oxygen species production that can negatively affect cancer cell survival. Significantly, knockdown of PINK1 or Parkin, two positive regulators of mitophagy, also impaired anoikis resistance and anchorage-independent growth of Ras-transformed human cells, while knockdown of USP30, a negative regulator of PINK1/Parkin-mediated mitophagy, restored anchorage-independent growth of STK38-depleted Ras-transformed human cells. Therefore, our findings collectively reveal novel molecular players that determine whether Ras-transformed human cells die or survive upon cell detachment, which potentially could be exploited for the development of novel strategies to target Ras-transformed cells. PMID:27283898

Division of Forestry Directory

Science.gov (United States)

Conservation Education Timber Management Wildland Fire & Aviation Burn Permits Firewise Alaska Brochure -8441 Safety Officer Tom Greiling thomas.greiling@alaska.gov (907) 761-6247 Fire Prevention Officer /SATS Radio Shop 5900 East Tudor Road Anchorage, AK 99507 nathan.skinner@alaska.gov (907) 451-2810 State

Seismic Adequacy Review of PC012 SCEs that are Potential Seismic Hazards with PC3 SCEs - CVD Facility

International Nuclear Information System (INIS)

OCOMA, E.C.

1999-01-01

This document provides seismic adequacy review of PCO12 Systems, Components L Equipment anchorage that are potential seismic interaction hazards with PC3 SCEs during a Design Basis Earthquake. The PCO12 items are identified in the Safety Equipment List as 3/1 SCEs

Tools to Compare Diving-Animal Kinematics with Acoustic Behavior and Exposure

Science.gov (United States)

2011-09-30

to humpback whales; under Dr. Stephen Insley, then at the University of California at Santa Cruz , to northern fur seals (Figure 3; Insley et al...Richardson (Anchorage, Alaska) and Dr. Manuel Castellote of the National Marine Mammal Laboratory to assess applicability of the Acousonde 3B to

Welcome Aboard Starship MIR: Mission Is Russian

Science.gov (United States)

Gullickson, Janice

2009-01-01

Six years ago Project Starship MIR, the Russian language "shuttle," launched at Turnagain Elementary, one of the Anchorage School District's 65 elementary schools. The MIR "peace" mission originated with encouragement from the local business community to prepare students for Alaska's future economic, social and political ties…

Un error en los calculos matematicos destroza el acelerador de particulas del CERN

CERN Multimedia

Cernuda, Olalla

2007-01-01

The most famous particle accelerator in the world, who is at CERN, has suffered a catastrophic damage after a great explosion took place in its depths. This explosion has an absolutely scientific explanation: a mathematical mistake in the design of the anchorages of great magnets. (1 page)

14 CFR 93.51 - Applicability.

Science.gov (United States)

2010-01-01

... AND GENERAL OPERATING RULES SPECIAL AIR TRAFFIC RULES Anchorage, Alaska, Terminal Area § 93.51... 14 Aeronautics and Space 2 2010-01-01 2010-01-01 false Applicability. 93.51 Section 93.51..., Terminal Area. [Doc. No. FAA-2002-13235, 68 FR 9795, Feb. 28, 2003] ...

29 CFR 1918.85 - Containerized cargo operations.

Science.gov (United States)

2010-07-01

...” (activated) container gantry crane lifting beams or attached devices are used as anchorage points, the... maximum cargo weight, in pounds. (b) Container weight. No container shall be hoisted by any lifting... of loading or discharging, or every crane or other hoisting equipment operator and signalman, that...

The politics of symmetry

NARCIS (Netherlands)

Pels, D.L.

While symmetry and impartiality have become ruling principles in S&TS, defining its core ideal of a 'value-free relativism', their philosophical anchorage has attracted much less discussion than the issue or:how far their jurisdiction can be extended or generalized. This paper seeks to argue that

On the plastic behaviour of multi directional epoxy-bolted CFRP laminates

DEFF Research Database (Denmark)

Jensen, Aage; Poulsen, Ervin

2004-01-01

The second generation of CFRP laminate has recently been developed. It is a multi directional CFRP laminate, i.e. a laminate with carbon fibres having several directions other than the first generation. The paper describes the laboratory tests carried out in order to develop anchorage devices for...

Public Health Nursing: Public Health Centers

Science.gov (United States)

Misuse and Addiction Prevention Finance & Management Services Health Care Services Juvenile Justice , Alaska 99752 Phone: 442-7144 Fax: 442-7292 e-mail: Josephine Oke, Program Manager [back to top] North Phone: 852-0270 Fax: 852-2855 email: Andrey Boskhomdzhiev [back to top] Municipality of Anchorage P.O

Immediate endovascular stent-graft repair of an acute traumatic

African Journals Online (AJOL)

Enrique

device intended for abdominal deployment. The stent-graft was manually removed from its short delivery device and ... Largely on the basis of the Parmley report, standard teaching was that these injuries ... 5 mm to allow adequate proximal anchorage. Tactics to ... Temporary hypotension is generally induced during the.

CANINE ECTOPIC TREATMENT WITH FIRST MOLAR EXTRACTION

Directory of Open Access Journals (Sweden)

Angelica Margo

2015-06-01

Full Text Available Decision to extract or not and the type of tooth must be analyzed carefully in orthodontic treatment. Preferable tooth to be extracted was the tooth with large caries or restoration. Usually the type of tooth to be extracted was second molar (if the third molar appears, incisor, first molar, and combination of several teeth. Orthodontic treatment with molar extraction is more difficult to treat and the result is usually compromise. There are several considerations in extracting first molar such as tooth with large caries or restoration, hypoplasia, periapical disease, large discrepancy, high maxilla-mandibular plane angle, and cases with anterior open bite. Nowadays, orthodontic cases with molar extraction do not prolong the treatment time compared to premolar extraction case, but the anchorage system must be considered carefully. The present case was treated with extraction of first molar to solve anterior crowding with maximum anchorage at the upper jaw and using Nance Holding Appliance.

Flexural Behavior of Self-Compacting RC Continuous Beams Strengthened by CFRP Sheets

Directory of Open Access Journals (Sweden)

Sabih Z. Al-Sarraf

2018-01-01

Full Text Available This search presented an experimental study of the flexural behavior of self-compacting reinforced concrete continuous beams externally strengthened by carbon fiber reinforced polymer (CFRP Sheets. The practical study contained eight self-compacting reinforced concrete continuous beams (with two span, each span had (1500 mm length and (150x250 mm cross sectional dimensions. Seven of these beams strengthened externally by CFRP sheets with and without external anchorage. The experimental variables included location of CFRP sheets and anchor type and location. The results, shows that the beams strengthened externally by CFRP sheets provided improvement in ultimate loads reached (60.71%. The usage of CFRP in the anchorage zone indicated an effective method in comparison to increasing the CFRP sheets lengths or extending them up to the support or under the loading points. Test results also showed that side strengthening provided an effective tool for increasing the load at the cracking stage and also the load capacity and reducing flexural crack widths.

Platelet-rich plasma—an ‘Elixir’ for treatment of alopecia: personal experience on 117 patients with review of literature

Science.gov (United States)

Manchanda, Shweta

2017-01-01

Platelet-rich plasma (PRP) has emerged as a new treatment modality in regenerative plastic surgery and dermatology. PRP is a simple, cost-effective and feasible treatment option with high patient satisfaction for hair loss and can be regarded as a valuable adjuvant treatment modality for androgenic alopecia and other types of non-scarring alopecias. Authors have proposed a hair model termed “Golden anchorage with ‘molecular locking’ of ectodermal and mesenchymal components for survival and integrity of hair follicle (HF)” in this article. Golden anchorage comprises of bulge stem cells, ectodermal basement membrane and bulge portion of APM. PRP with its autologous supply of millions of growth factors works on ‘Golden anchorage’ along with keratinocytes (PDGF), dermal papilla (IGF and fibroblast growth factor), vasculature (VEGF and PDGF) and neural cells (Nerve Growth Factor) in a multipronged manner serving as an ‘elixir’ for hair growth and improving overall environment. PMID:28815175

Understanding the basis of space closure in Orthodontics for a more efficient orthodontic treatment.

Science.gov (United States)

Ribeiro, Gerson Luiz Ulema; Jacob, Helder B

2016-01-01

Space closure is one of the most challenging processes in Orthodontics and requires a solid comprehension of biomechanics in order to avoid undesirable side effects. Understanding the biomechanical basis of space closure better enables clinicians to determine anchorage and treatment options. In spite of the variety of appliance designs, space closure can be performed by means of friction or frictionless mechanics, and each technique has its advantages and disadvantages. Friction mechanics or sliding mechanics is attractive because of its simplicity; the space site is closed by means of elastics or coil springs to provide force, and the brackets slide on the orthodontic archwire. On the other hand, frictionless mechanics uses loop bends to generate force to close the space site, allowing differential moments in the active and reactive units, leading to a less or more anchorage control, depending on the situation. This article will discuss various theoretical aspects and methods of space closure based on biomechanical concepts.

Understanding the basis of space closure in Orthodontics for a more efficient orthodontic treatment

Directory of Open Access Journals (Sweden)

Gerson Luiz Ulema Ribeiro

2016-04-01

Full Text Available ABSTRACT Introduction: Space closure is one of the most challenging processes in Orthodontics and requires a solid comprehension of biomechanics in order to avoid undesirable side effects. Understanding the biomechanical basis of space closure better enables clinicians to determine anchorage and treatment options. In spite of the variety of appliance designs, space closure can be performed by means of friction or frictionless mechanics, and each technique has its advantages and disadvantages. Friction mechanics or sliding mechanics is attractive because of its simplicity; the space site is closed by means of elastics or coil springs to provide force, and the brackets slide on the orthodontic archwire. On the other hand, frictionless mechanics uses loop bends to generate force to close the space site, allowing differential moments in the active and reactive units, leading to a less or more anchorage control, depending on the situation. Objective: This article will discuss various theoretical aspects and methods of space closure based on biomechanical concepts.

Contemporary solutions for managing Class III malocclusion

Directory of Open Access Journals (Sweden)

Nathamuni Rengarajan Krishnaswamy

2015-01-01

Full Text Available Although patients with Class III malocclusions constitute a small percentage of the average orthodontic practice, providing them with optimal treatment is a daunting task. The treatment approach is dependent upon the growth status of the individual and the severity of the skeletal dysplasia. For growing individuals, facemask therapy to protract the maxilla is ineffective because of its dependence on dental anchorage to bring forth skeletal correction. Orthodontic camouflage in nongrowing mild skeletal Class III individuals is met with limited success because of the anatomical boundaries and the conventional biomechanics. Orthognathic surgery to correct the maxillomandibular relations is time-consuming, and the facial esthetics is compromised during the orthodontic decompensation period. Contemporary solutions to overcome these limitations are now viable with the use of temporary anchorage devices and by performing surgery prior to orthodontic decompensation. The rationale for employing these contemporary approaches will be discussed in this study with illustrative cases.

Down-regulation of Rab5 decreases characteristics associated with maintenance of cell transformation

International Nuclear Information System (INIS)

Silva, Patricio; Soto, Nicolás; Díaz, Jorge; Mendoza, Pablo; Díaz, Natalia; Quest, Andrew F.G.; Torres, Vicente A.

2015-01-01

The early endosomal protein Rab5 is highly expressed in tumor samples, although a causal relationship between Rab5 expression and cell transformation has not been established. Here, we report the functional effects of targeting endogenous Rab5 with specific shRNA sequences in different tumor cell lines. Rab5 down-regulation in B16-F10 cells decreased tumor formation by subcutaneous injection into C57/BL6 mice. Accordingly, Rab5 targeting in B16-F10 and A549, but not MDA-MB-231 cells was followed by decreased cell proliferation, increased apoptosis and decreased anchorage-independent growth. These findings suggest that Rab5 expression is required to maintain characteristics associated with cell transformation. - Highlights: • Rab5 is important to the maintenance of cell transformation characteristics. • Down-regulation of Rab5 decreases cell proliferation and increases apoptosis in different cancer cells. • Rab5 is required for anchorage-independent growth and tumorigenicity in-vivo

75 FR 26100 - Danger Zone, Pacific Ocean, Naval Base Coronado, Coronado, California

Science.gov (United States)

2010-05-11

... the maritime community, including yacht club races; bait hauling for sports fishing charters... anchorage along the Zuniga Jetty is not affected by the final rule. The majority of yacht and sailboat.... Coast Guard and the NBC SAR would be necessary, no loss of organized yacht racing areas or sailing...

33 CFR 110.230 - Puget Sound Area, Wash.

Science.gov (United States)

2010-07-01

..., the following hierarchy will be applied for assignment of a berth: tankers conducting lightering operations, then loaded tankers, and then all other vessels. (ii) Tugs and oil barges using the Cap Sante and... the Captain of the Port. (5) Within the Anacortes General Anchorages, lightering operations shall only...

77 FR 24265 - Toyota Motor Corporation, Inc., on Behalf of Toyota Corporation, and Toyota Manufacturing...

Science.gov (United States)

2012-04-23

..., symbols or pictograms are used, their meaning is explained to the consumer in writing, such as in the... and horizontal longitudinal planes intersecting at the horizontal centerline of each lower anchorage, as illustrated in Figure 22. The center of the circle must be in the vertical longitudinal plane that...

30 CFR 902.10 - State regulatory program approval.

Science.gov (United States)

2010-07-01

... Mining and Water Management, 3601 C Street, Suite 800, Anchorage, AK 99503-5925, Telephone: (907) 762... Section 902.10 Mineral Resources OFFICE OF SURFACE MINING RECLAMATION AND ENFORCEMENT, DEPARTMENT OF THE INTERIOR PROGRAMS FOR THE CONDUCT OF SURFACE MINING OPERATIONS WITHIN EACH STATE ALASKA § 902.10 State...

50 CFR 27.92 - Private structures.

Science.gov (United States)

2010-10-01

... 50 Wildlife and Fisheries 6 2010-10-01 2010-10-01 false Private structures. 27.92 Section 27.92... NATIONAL WILDLIFE REFUGE SYSTEM PROHIBITED ACTS Other Disturbing Violations § 27.92 Private structures. No..., pier, dock, fence, wall, pile, anchorage, or other structure or obstruction in any national wildlife...

33 CFR 110.235 - Pacific Ocean (Mamala Bay), Honolulu Harbor, Hawaii (Datum: NAD 83).

Science.gov (United States)

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Pacific Ocean (Mamala Bay), Honolulu Harbor, Hawaii (Datum: NAD 83). 110.235 Section 110.235 Navigation and Navigable Waters COAST... Pacific Ocean (Mamala Bay), Honolulu Harbor, Hawaii (Datum: NAD 83). (a) The anchorage grounds—(1...

75 FR 7517 - Notice of Intent To Prepare an Amendment to the Ring of Fire Resource Management Plan for the...

Science.gov (United States)

2010-02-19

... Municipality of Anchorage. This planning activity encompasses approximately 730 acres of public land in the Ring of Fire planning area. The BLM released the Ring of Fire RMP Record of Decision (ROD) in March... be addressed by this planning effort are increased annual visitation, commercial use, on- going trail...

76 FR 9868 - Office of Hazardous Materials Safety; Notice of Application for Special Permits

Science.gov (United States)

2011-02-22

... intermediate bulk containers for use as the outer packaging for certain Class waste paints and waste paint.... commerce of certain Anchorage, AK. flammable and combustible liquids in alternative packaging having a... Structural 49 CFR 173.302a and To authorize the Composites 173.304a. manufacture, marking, Industries, (SCI...

75 FR 8791 - Continuation of the National Emergency Relating to Cuba and of the Emergency Authority Relating...

Science.gov (United States)

2010-02-25

... to Cuba and of the Emergency Authority Relating to the Regulation of the Anchorage and Movement of... February 23, 2010 Continuation of the National Emergency Relating to Cuba and of the Emergency Authority....-registered civilian aircraft in international airspace north of Cuba. On February 26, 2004, by Proclamation...

33 CFR 110.214 - Los Angeles and Long Beach harbors, California.

Science.gov (United States)

2010-07-01

... Angeles Harbor). A circular area with a radius of 400 yards (approximately 366 meters), centered in... 400 Transportation Corridor. (C) Outer Harbor: The western boundary of Commercial Anchorage B. (2... Thence along a line described as an arc, radius of 460 meters (approximately 1509 feet) centered on 33...

Corticotomy-assisted retraction: An outcome assessment

Directory of Open Access Journals (Sweden)

S Vijayashri Sakthi

2014-01-01

Conclusion: The rate of retraction with study group was twice as faster when compared to the control group, accelerating during the first 2 months of retraction. There was better anchorage control with the undecorticated molar segment during the retraction period but was found to increase as time advanced.

33 CFR 110.197 - Galveston Harbor, Bolivar Roads Channel, Texas.

Science.gov (United States)

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Galveston Harbor, Bolivar Roads Channel, Texas. 110.197 Section 110.197 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF... Roads Channel, Texas. (a)(1) Anchorage area (A). The water bounded by a line connecting the following...

33 CFR 334.865 - Naval Air Station North Island, San Diego, California, restricted area.

Science.gov (United States)

2010-07-01

... shall not be open to swimming, fishing, water-skiing, mooring or anchorage. (2) Dragging, seining, other fishing operations, and other activities not under the direction of the United States, which might foul... shall not be dragged along the bottom while proceeding through the area. (4) All vessels entering the...

Sortilin regulates progranulin action in castration-resistant prostate cancer cells.

Science.gov (United States)

Tanimoto, Ryuta; Morcavallo, Alaide; Terracciano, Mario; Xu, Shi-Qiong; Stefanello, Manuela; Buraschi, Simone; Lu, Kuojung G; Bagley, Demetrius H; Gomella, Leonard G; Scotlandi, Katia; Belfiore, Antonino; Iozzo, Renato V; Morrione, Andrea

2015-01-01

The growth factor progranulin is as an important regulator of transformation in several cellular systems. We have previously demonstrated that progranulin acts as an autocrine growth factor and stimulates motility, proliferation, and anchorage-independent growth of castration-resistant prostate cancer cells, supporting the hypothesis that progranulin may play a critical role in prostate cancer progression. However, the mechanisms regulating progranulin action in castration-resistant prostate cancer cells have not been characterized. Sortilin, a single-pass type I transmembrane protein of the vacuolar protein sorting 10 family, binds progranulin in neurons and negatively regulates progranulin signaling by mediating progranulin targeting for lysosomal degradation. However, whether sortilin is expressed in prostate cancer cells and plays any role in regulating progranulin action has not been established. Here, we show that sortilin is expressed at very low levels in castration-resistant PC3 and DU145 cells. Significantly, enhancing sortilin expression in PC3 and DU145 cells severely diminishes progranulin levels and inhibits motility, invasion, proliferation, and anchorage-independent growth. In addition, sortilin overexpression negatively modulates Akt (protein kinase B, PKB) stability. These results are recapitulated by depleting endogenous progranulin in PC3 and DU145 cells. On the contrary, targeting sortilin by short hairpin RNA approaches enhances progranulin levels and promotes motility, invasion, and anchorage-independent growth. We dissected the mechanisms of sortilin action and demonstrated that sortilin promotes progranulin endocytosis through a clathrin-dependent pathway, sorting into early endosomes and subsequent lysosomal degradation. Collectively, these results point out a critical role for sortilin in regulating progranulin action in castration-resistant prostate cancer cells, suggesting that sortilin loss may contribute to prostate cancer progression.

Quantitative analysis on orientation of human bone integrated with midpalatal implant by micro X-ray diffractometer

Science.gov (United States)

Murata, Masaru; Akazawa, Toshiyuki; Yuasa, Toshihiro; Okayama, Miki; Tazaki, Junichi; Hanawa, Takao; Arisue, Makoto; Mizoguchi, Itaru

2012-12-01

A midpalatal implant system has been used as the unmoved anchorage for teeth movement. An 18-year-old male patient presented with reversed occlusion and was diagnosed as malocclusion. A pure titanium fixture (lengths: 4 mm, diameter: 3.3 mm, Orthosystem®, Institute Straumann, Switzerland) was implanted into the palatal bone of the patient as the orthodontic anchorage. The implant anchorage was connected with the upper left and right first molars, and had been used for 3 years. After dynamic treatments, the titanium fixture connected with bone was removed surgically, fixed in formalin solution, and embedded in resin. Specimens were cut along the frontal section of face and the direction of longitudinal axis of the implant, stained, and observed histologically. The titanium fixture was integrated directly with compact bone showing cortical bone-like structure such as lamella and osteon. In addition, to qualitatively characterize the implant-supported human bone, the crystallinity and orientation of hydroxyapatite (HAp) phase were evaluated by the microbeam X-ray diffraction analysis. Preferential alignment of c-axis of HAp crystals was represented by the relative intensity ratio of (0 0 2)-face diffraction peak to (3 1 0)-face one. The values decreased monotonously along the direction of the lateral stress from the site near the implant thread to the distant site in all horizontal lines of the map. These results indicated that the X-ray images for the intensity of c-face in HAp revealed functionally graded distribution of cortical bone quality. The micro-scale measurements of HAp structure could be a useful method for evaluating the mechanical stress distribution in human hard tissues.

Global ballast water management and the "same location" concept: a clear term or a clear issue?

Science.gov (United States)

David, Matej; Gollasch, Stephan; Pavliha, Marko

2013-03-01

The United Nations recognized the transfer of harmful organisms and pathogens across natural barriers as one of the four greatest pressures to the world's oceans and seas, causing global environmental changes, while also posing a threat to human health, property, and resources. Ballast water transferred by vessels was recognized as a prominent vector of such species and was regulated by the International Convention for the Control and Management of Ship's Ballast Water and Sediments (2004). Permanent exceptions from ballast water management requirements may apply when the uptake and discharge of ballast water occur at the "same location." However, the "same location" concept may be interpreted differently, e.g., a port basin, a port, an anchorage, or a larger area even with more ports inside. Considering that the Convention is nearing the beginning of enforcement, national authorities all around the world will soon be exposed to applications for exceptions. Here we consider possible effects of different interpretations of the "same location" concept. We have considered different possible extensions of the same location through environmental, shipping, and legal aspects. The extension of such areas, and the inclusion of more ports, may compromise the Convention's main purpose. We recommend that "same location" mean the smallest practicable unit, i.e., the same harbor, mooring, or anchorage. An entire smaller port, possibly also including the anchorage, could be considered as same location. For larger ports with a gradient of environmental conditions, "same location" should mean a terminal or a port basin. We further recommend that IMO consider the preparation of a guidance document to include concepts, criteria, and processes outlining how to identify "same location," which limits should be clearly identified.

Resistance to experimental tumorigenesis in cells of a long-lived mammal, the naked mole-rat (Heterocephalus glaber).

Science.gov (United States)

Liang, Sitai; Mele, James; Wu, Yuehong; Buffenstein, Rochelle; Hornsby, Peter J

2010-08-01

The naked mole-rat (NMR, Heterocephalus glaber) is a long-lived mammal in which spontaneous cancer has not been observed. To investigate possible mechanisms for cancer resistance in this species, we studied the properties of skin fibroblasts from the NMR following transduction with oncogenes that cause cells of other mammalian species to form malignant tumors. Naked mole-rat fibroblasts were transduced with a retrovirus encoding SV40 large T antigen and oncogenic Ras(G12V). Following transplantation of transduced cells into immunodeficient mice, cells rapidly entered crisis, as evidenced by the presence of anaphase bridges, giant cells with enlarged nuclei, multinucleated cells, and cells with large number of chromosomes or abnormal chromatin material. In contrast, similarly transduced mouse and rat fibroblasts formed tumors that grew rapidly without crisis. Crisis was also observed after > 40 population doublings in SV40 TAg/Ras-expressing NMR cells in culture. Crisis in culture was prevented by additional infection of the cells with a retrovirus encoding hTERT (telomerase reverse transcriptase). SV40 TAg/Ras/hTERT-expressing NMR cells formed tumors that grew rapidly in immunodeficient mice without evidence of crisis. Crisis could also be induced in SV40 TAg/Ras-expressing NMR cells by loss of anchorage, but after hTERT transduction, cells were able to proliferate normally following loss of anchorage. Thus, rapid crisis is a response of oncogene-expressing NMR cells to growth in an in vivo environment, which requires anchorage independence, and hTERT permits cells to avoid crisis and to achieve malignant tumor growth. The unique reaction of NMR cells to oncogene expression may form part of the cancer resistance of this species.

[Comparison of two types of cell cultures for preparation of sTNFRII-gAD fusion protein].

Science.gov (United States)

Huang, Shigao; Yin, Yuting; Xiong, Chunhui; Wang, Caihong; Lü, Jianxin; Gao, Jimin

2013-01-01

In this study we used two types of cell cultures, i.e., anchorage-dependent basket and full suspension batch cultures of sTNFRII-gAD-expressing CHO cells in the CelliGen 310 bioreactor (7.5 L) to compare their yields in order to optimize the culturing conditions for efficient expression of sTNFRII-gAD fusion protein consisting of soluble tumor necrosis factor receptor II and globular domain of adiponectin. The anchorage-dependent basket culture was performed in 4L 10% serum-containing medium with the final inoculating concentration of 3 x 10(5) to 4 x 10(5) cells/mL of sTNFRII-gAD-expressing CHO cells for 3 days, and then switched to 4 L serum-free LK021 medium to continue the culture for 4 days. The full suspension batch culture was carried out in the 4 L serum-free LK021 medium with the final inoculating concentration of 3 x 10(5) to 4 x 10(5) cells/mL of sTNFRII-gAD-expressing CHO cells for 7 days. The culturing conditions were monitored in real-time to maintain pH and dissolved oxygen stability through the whole process. The supernatants were collected by centrifuge, and the protein was concentrated through Pellicon flow ultrafiltration system and then purified by DEAE anion exchange. The results showed that the yields of sTNFRII-gAD fusion protein were 8.0 mg/L with 95% purity and 7.5 mg/L with 98% purity in the anchorage-dependent basket and the full suspension batch cultures, respectively. The study provided the framework for the pilot production of sTNFRII-gAD fusion protein.

Earthquake Hazard and Risk in Alaska

Science.gov (United States)

Black Porto, N.; Nyst, M.

2014-12-01

Alaska is one of the most seismically active and tectonically diverse regions in the United States. To examine risk, we have updated the seismic hazard model in Alaska. The current RMS Alaska hazard model is based on the 2007 probabilistic seismic hazard maps for Alaska (Wesson et al., 2007; Boyd et al., 2007). The 2015 RMS model will update several key source parameters, including: extending the earthquake catalog, implementing a new set of crustal faults, updating the subduction zone geometry and reoccurrence rate. First, we extend the earthquake catalog to 2013; decluster the catalog, and compute new background rates. We then create a crustal fault model, based on the Alaska 2012 fault and fold database. This new model increased the number of crustal faults from ten in 2007, to 91 faults in the 2015 model. This includes the addition of: the western Denali, Cook Inlet folds near Anchorage, and thrust faults near Fairbanks. Previously the subduction zone was modeled at a uniform depth. In this update, we model the intraslab as a series of deep stepping events. We also use the best available data, such as Slab 1.0, to update the geometry of the subduction zone. The city of Anchorage represents 80% of the risk exposure in Alaska. In the 2007 model, the hazard in Alaska was dominated by the frequent rate of magnitude 7 to 8 events (Gutenberg-Richter distribution), and large magnitude 8+ events had a low reoccurrence rate (Characteristic) and therefore didn't contribute as highly to the overall risk. We will review these reoccurrence rates, and will present the results and impact to Anchorage. We will compare our hazard update to the 2007 USGS hazard map, and discuss the changes and drivers for these changes. Finally, we will examine the impact model changes have on Alaska earthquake risk. Consider risk metrics include average annual loss, an annualized expected loss level used by insurers to determine the costs of earthquake insurance (and premium levels), and the

Class III camouflage using skeletal anchorage and Pendex appliance.

Science.gov (United States)

Miguel, José Augusto M; Zanardi, Gustavo

2011-01-01

This case report describes the orthodontic treatment for a young female, aged 18 years 4 months, with a Class III malocclusion on the right side, with a combination of a posterior and anterior crossbite. Two rigid orthodontic mini-implants were placed in the retromolar region in order to move the entire lower arch distally with nickel-titanium coil springs. In addition, a Pendex appliance was used to create space and to improve the arch form and the transverse relationship. The active treatment period was 17 months. Normal overjet and overbite were obtained, and facial balance was improved. Although the cephalometric superimposition has demonstrated the effects of dental compensation, the final dental and facial results were satisfactory and stable after the second year in retention. Copyright © 2011 Società Italiana di Ortodonzia SIDO. Published by Elsevier Srl. All rights reserved.

77 FR 54493 - Special Anchorage Area; Stockton Springs, ME

Science.gov (United States)

2012-09-05

... and tourist attractions in Penobscot Bay. Vessels not more than 20 meters in length are not required... substantial direct effect on the States, on the relationship between the national government and the States... more Indian tribes, on the relationship between the Federal Government and Indian tribes, or on the...

The North sea, one of the group's anchorage points

International Nuclear Information System (INIS)

Anon.

1995-01-01

The North Sea is one of the pillars of the Elf Aquitaine group's Exploration-Production strategy. The most recent start-up in the North Sea, last february, concerned the Froy field where Elf Petroleum Norge (AS) is an operator with a 24.573 % interest alongside Statoil, Total Norge AS (15.2346 %) and Norsk Hydro. The first gas sales occurred on June 15, as scheduled. The oil production marketed by Elf (net of royalties) remained stable at 13.9 Gm 3 . At january 1,1995, Elf Aquitaine's mining area covered a gross surface area of 435,894 km 2 . In countries where the group is already established, the policy is : - to withdraw from exploration licenses considered as being the least promising in terms of discovery or profitability; - to concentrate on sectors where the existing production means allow for an optimisation of later developments ; - to penetrate more extensive exploration areas with good targets. In the British zone, the additional reserves revealed in the Elgin and Franklin condensate fields have doubled the initial forecast, placing the former among the major fields. All the discoveries made in the British zone have allowed the group to renew productions until now. Elf's production in Piper, Saltire, Chanter is 100,000 b/d which is added to the production of the Claymore and Scapa fields (100,000 b/d). The Flotta terminal processes the crude coming from these fields to which is added the production from the neighbouring fields of Tartan (Texaco) and Ivanhoe-Rob Roy (Amerada Hess), i.e. a total of more than 300,000 b/d. Other than Elgin or the Viking Graben, the future of the Elf group in Great Britain will most certainly come from the West Shetlands and the Irish Sea. In the Norwegian zone, the group has interest in the Frigg, Heimldal, Ekofisk, Valhall, Lille-Frigg, Froy, Oseberg, Hod, Sleipner East an Sleipner West Brage, Troll, Snorre, Statfjord East and Tordis production fields. (authors). 3 tabs., 1 photo

77 FR 74470 - Intent to Prepare an Environmental Impact Statement (EIS) for the Donlin Gold Project

Science.gov (United States)

2012-12-14

... impacts associated with the proposed Donlin Gold Project, which would be an open pit, hardrock gold mine... proposing the development of an open pit, hardrock gold mine located 277 miles west of Anchorage, 145 miles.... Major project components include excavation of an open pit, that ultimately would be approximately 2.2...

'Through a Glass Darkly': Assessing the 'New' War Against ...

African Journals Online (AJOL)

submits that while the legal and institutional anchorages of the war offer a good point of departure, they remain grossly inadequate. This largely explains why the war has been underproductive and caught in a deepening crisis of legitimacy. What is required is the nourishing and re-envisioning of such frameworks, coupled

De veiligheid van vakantie-en recreatievervoer : lading op, in, aan of achter voertuigen. Consult ten behoeve van de Nederlandse Vereniging van Automobielassuradeuren (NVVA).

NARCIS (Netherlands)

Tromp, J.P.M.

1987-01-01

Problems with the load are often due to the strong modified driving behaviour or by the wrong anchorage of the load. The mostly incidental character of these problems in holiday and recreation traffic leads also to a lack of experience in supplied driving. There is also an attitude by many drivers

76 FR 25232 - Standard Instrument Approach Procedures, and Takeoff Minimums and Obstacle Departure Procedures...

Science.gov (United States)

2011-05-04

... a Flight Data Center (FDC) Notice to Airmen (NOTAM) as an emergency action of immediate flight... existing or anticipated at the affected airports. Because of the close and immediate relationship between... Anchorage, AK, Merill Field, Takeoff Minimums and Obstacle DP, Amdt 1 Big Lake, AK, Big Lake, RNAV (GPS) RWY...

49 CFR 179.220-11 - Postweld heat treatment.

Science.gov (United States)

2010-10-01

... 49 Transportation 2 2010-10-01 2010-10-01 false Postweld heat treatment. 179.220-11 Section 179... Postweld heat treatment. (a) Postweld heat treatment of the inner container is not a specification requirement. (b) Postweld heat treatment of the cylindrical portions of the outer shell to which the anchorage...

40 CFR 81.302 - Alaska.

Science.gov (United States)

2010-07-01

... Date Type Anchorage Community of Eagle River 11/15/90 Nonattainment 11/15/90 Moderate Juneau City of... river. Also, Township 1 South, Range 1 East, Sections 7, 8, and 18 and the portion of Section 19 north... urban area designated Nonattainment Kobuk Election District Nome Election District North Slope Election...

76 FR 53648 - Federal Motor Vehicle Safety Standards: Occupant Crash Protection

Science.gov (United States)

2011-08-29

... lower attachment nonusers cited their lack of knowledge--not knowing what the anchorages were, that they... LATCH- equipped DSPs because many parents and caregivers still rely on lockable belts to keep their... indicated that they knew what to do with the seat belt. These drivers who preferred to install CRSs with...

33 CFR 110.190 - Tortugas Harbor, in vicinity of Garden Key, Dry Tortugas, Fla.

Science.gov (United States)

2010-07-01

... Garden Key, Dry Tortugas, Fla. 110.190 Section 110.190 Navigation and Navigable Waters COAST GUARD..., in vicinity of Garden Key, Dry Tortugas, Fla. (a) The anchorage grounds. All of Bird Key Harbor, southwest of Garden Key, bounded by the surrounding reefs and shoals and, on the northeast, by a line...

75 FR 79334 - Meeting Notice

Science.gov (United States)

2010-12-20

... ARCTIC RESEARCH COMMISSION Meeting Notice Notice is hereby given that the U.S. Arctic Research Commission will hold its 95th meeting in Anchorage, AK, on January 21, 2011. The business session, open to... agenda. (2) Approval of the minutes from the 94th meeting. (3) Commissioners and staff reports. (4...

Rural Student Vocational Program (RSVP) [and] Housing Guide for Parents and Students [and] Work Supervisor's Guide.

Science.gov (United States)

Rural Student Vocational Program, Wasilla, AK.

The purpose of the Rural Student Vocational Program (RSVP) is to provide rural high school vocational students with work and other experiences related to their career objective. Students from outlying schools travel to Anchorage, Fairbanks, or Juneau (Alaska) to participate in two weeks of work experience with cooperating agencies and businesses.…

Case Studies Nested in Fuzzy-Set QCA on Sufficiency: Formalizing Case Selection and Causal Inference

Science.gov (United States)

Schneider, Carsten Q.; Rohlfing, Ingo

2016-01-01

Qualitative Comparative Analysis (QCA) is a method for cross-case analyses that works best when complemented with follow-up case studies focusing on the causal quality of the solution and its constitutive terms, the underlying causal mechanisms, and potentially omitted conditions. The anchorage of QCA in set theory demands criteria for follow-up…

77 FR 15455 - Notice of Delays in Processing of Special Permits Applications

Science.gov (United States)

2012-03-15

... Blasting Auburn, NH. 10646-M Schlumberger 4 03-31-2012 Technologies Corporation Sugar Land, TX. 14372-M.... 12283-R Interstate 4 03-31-2012 Battery of Alaska Anchorage, AK. 10709-R Schlumberger 4 03-31-2012 Technologies Corporation Sugar Land, TX. 11227-R Schlumberger 4 03-31-2012 Well Services a Division of...

77 FR 38859 - Governors' Designees Receiving Advance Notification of Transportation of Certain Shipments of...

Science.gov (United States)

2012-06-29

... of Transportation of Certain Shipments of Nuclear Waste and Spent Fuel On January 6, 1982 (47 FR 596 and 47 FR 600), the U.S. Nuclear Regulatory Commission (NRC) published in the Federal Register final... Conservation, State of Alaska, 555 Cordova Street, Anchorage, AK 99501, (907) 269- 1099, 24 hours: (907) 457...

75 FR 18164 - Procurement List: Proposed Additions and Deletions

Science.gov (United States)

2010-04-09

... . SUPPLEMENTARY INFORMATION: This notice is published pursuant to 41 U.S.C. 47(a)(2) and 41 CFR 51-2.3. Its.../Location: Janitorial Services, Corp of Engineers Buildings, Elmendorf AFB, AK, Corp of Engineers Buildings, Fort Richardson, AK. NPA: MQC Enterprises, Inc., Anchorage, AK. Contracting Activity: XR W2SN ENDIST...

29 CFR 1926.758 - Systems-engineered metal buildings.

Science.gov (United States)

2010-07-01

... 29 Labor 8 2010-07-01 2010-07-01 false Systems-engineered metal buildings. 1926.758 Section 1926... Systems-engineered metal buildings. (a) All of the requirements of this subpart apply to the erection of systems-engineered metal buildings except §§ 1926.755 (column anchorage) and 1926.757 (open web steel...

Red alder kitchen cabinets—How does application of commercial stains influence customer choice?

Science.gov (United States)

David Nicholls; Joseph. Roos

2007-01-01

A better understanding of consumer reaction and preferences for red alder (Alnus rubra Bong.) secondary products will help Alaska producers in entering new markets. In this study, red alder kitchen cabinets were commercially stained to six different levels and displayed at home shows in Portland, Oregon, and Anchorage, Alaska. The stains simulated...

77 FR 61157 - Final Fair Market Rents for the Housing Choice Voucher Program and Moderate Rehabilitation Single...

Science.gov (United States)

2012-10-05

... HMFA. Las Vegas-Paradise, NV MSA New Haven-Meriden, CT HMFA. North Port-Bradenton-Sarasota, FL MSA... areas of New Jersey, Anchorage and several non-metropolitan areas of Alaska, Dallas, TX and Burlington... Projects and Low-Income Housing Tax Credit Projects at Risk If a current HUD Section 8 project uses rents...

76 FR 70972 - Fisheries of the Exclusive Economic Zone off Alaska; Application for an Exempted Fishing Permit

Science.gov (United States)

2011-11-16

... meeting will be held at the Hilton Hotel, 500 West Third Ave., Anchorage, AK. The agenda for the Council... return to the sea with a minimum of injury. Halibut caught incidentally by catcher/processors in the... the directed fishery. In the case of the Bering Sea flatfish fishery, seasons have been closed before...

AMTC: Assessing Motivation To Communicate in the Ninth Grade Speech Class.

Science.gov (United States)

Fenton, Ray

A study examined the results of the use of the "Assessing Motivation To Communicate" (AMTC) computerized program with high school students in Anchorage, Alaska, during the 1995-96 school year. The AMTC consists of two self-assessment instruments: the Personal Report of Communication (PRCA-24) and the Willingness to Communicate (WTC).…

78 FR 53189 - Dorel Juvenile Group, Denial of Petition for Decision of Inconsequential Noncompliance

Science.gov (United States)

2013-08-28

... anchorage belts. According to DJG, the 26 vehicles represented a cross-section of vehicles on the road. The... is one of the DJG models included in this petition. Based on CU observations, the rear-facing belt...). NHTSA received one comment from Consumers Union (CU). To view the petition, the comment, and all...

Impaction of Maxillary Central Incisors: Surgical and Orthodontic Treatment--Case Report.

Science.gov (United States)

Knop, Luegya Amorim Henriques; Shintcovsk, Ricardo Lima; Gandini, Luiz Gonzaga; Parsekian, Lidia; Pinto, Ary Santos

2015-01-01

The aim of this paper is to report two clinical cases, which was performed with surgical exposure and orthodontic traction of a maxillary central incisors. Light forces were used during the orthodontic treatment applied on rigid wires as anchorage. It was noted that teeth presented adequate clinical crown height and gingival contours.

33 CFR 110.224 - San Francisco Bay, San Pablo Bay, Carquinez Strait, Suisun Bay, Sacramento River, San Joaquin...

Science.gov (United States)

2010-07-01

... area shown on a Government chart. (5) No vessel may moor, anchor, or tie up to any pier, wharf, or... supervision may go alongside or in any manner moor to any Government-owned vessel, mooring buoy, or pontoon...); and the side boundaries of which are parallel tangents joining the semicircles. A forbidden anchorage...

76 FR 11071 - Continuation of the National Emergency With Respect to Cuba and of the Emergency Authority...

Science.gov (United States)

2011-02-28

...--Continuation of the National Emergency With Respect to Cuba and of the Emergency Authority Relating to the... Respect to Cuba and of the Emergency Authority Relating to the Regulation of the Anchorage and Movement of... north of Cuba. On February 26, 2004, by Proclamation 7757, the national emergency was extended and its...

78 FR 13207 - Continuation of the National Emergency With Respect to Cuba and of the Emergency Authority...

Science.gov (United States)

2013-02-26

...--Continuation of the National Emergency With Respect to Cuba and of the Emergency Authority Relating to the... Respect to Cuba and of the Emergency Authority Relating to the Regulation of the Anchorage and Movement of... north of Cuba. On February 26, 2004, by Proclamation 7757, the national emergency was extended and its...

Assessment of Superstructure Ice Protection as Applied to Offshore Oil Operations Safety: Problems, Hazards, Needs, and Potential Transfer Technologies

Science.gov (United States)

2008-09-01

factor. The Rowan Gorilla I jack-up sank during a tow in a severe North Atlantic storm in December 1988. Severe seas, and not icing, was the suspected...Papineau, J., n.d., Anatomy of High Wind Events Along Alaska’s North Slope. National Weather Service, Anchorage, AK. (http://pafc.arh.noaa.gov/papers

Alaskan Native High School Dropouts: A Report Prepared for Project ANNA.

Science.gov (United States)

Jacobson, Desa

Presented is a summary of the Alaskan Native high school dropouts. The data collected on 180 Native Alaskan high school dropouts was taken from the regional dormitories at Nome, Kodiak, Bethel and Boarding Home programs in Anchorage, Tok, Fairbanks, Dillingham, and Ketchikan. Students who terminated for academic reasons, failed to attend school,…

PHTS, a novel putative tumor suppressor, is involved in the transformation reversion of HeLaHF cells independently of the p53 pathway

International Nuclear Information System (INIS)

Yu Dehua; Fan, Wufang; Liu, Guohong; Nguy, Vivian; Chatterton, Jon E.; Long Shilong; Ke, Ning; Meyhack, Bernd; Bruengger, Adrian; Brachat, Arndt; Wong-Staal, Flossie; Li, Qi-Xiang

2006-01-01

HeLaHF is a non-transformed revertant of HeLa cells, likely resulting from the activation of a putative tumor suppressor(s). p53 protein was stabilized in this revertant and reactivated for certain transactivation functions. Although p53 stabilization has not conclusively been linked to the reversion, it is clear that the genes in p53 pathway are involved. The present study confirms the direct role of p53 in HeLaHF reversion by demonstrating that RNAi-mediated p53 silencing partially restores anchorage-independent growth potential of the revertant through the suppression of anoikis. In addition, we identified a novel gene, named PHTS, with putative tumor suppressor properties, and showed that this gene is also involved in HeLaHF reversion independently of the p53 pathway. Expression profiling revealed that PHTS is one of the genes that is up-regulated in HeLaHF but not in HeLa. It encodes a putative protein with CD59-like domains. RNAi-mediated PHTS silencing resulted in the partial restoration of transformation (anchorage-independent growth) in HeLaHF cells, similar to that of p53 gene silencing, implying its tumor suppressor effect. However, the observed increased transformation potential by PHTS silencing appears to be due to an increased anchorage-independent proliferation rate rather than suppression of anoikis, unlike the effect of p53 silencing. p53 silencing did not affect PHTS gene expression, and vice versa, suggesting PHTS may function in a new and p53-independent tumor suppressor pathway. Furthermore, over-expression of PHTS in different cancer cell lines, in addition to HeLa, reduces cell growth likely via induced apoptosis, confirming the broad PHTS tumor suppressor properties

Sublethal concentrations of the platinum(II) complex [Pt(O,O'-acac)(gamma-acac)(DMS)] alter the motility and induce anoikis in MCF-7 cells.

Science.gov (United States)

Muscella, Antonella; Calabriso, Nadia; Vetrugno, Carla; Urso, Loredana; Fanizzi, Francesco Paolo; De Pascali, Sandra Angelica; Marsigliante, Santo

2010-07-01

We showed previously that a new Pt(II) complex ([Pt(O,O'-acac)(gamma-acac)(DMS)]) exerted high and fast apoptotic processes in MCF-7 cells. The objective of this study was to investigate the hypothesis that [Pt(O,O'-acac)(gamma-acac)(DMS)] is also able to exert anoikis and alter the migration ability of MCF-7 cells, and to show some of the signalling events leading to these alterations. Cells were treated with sublethal doses of [Pt(O,O'-acac)(gamma-acac)(DMS)], and the efficiency of colony initiation and anchorage-independent growth was assayed; cell migration was examined by in vitro culture wounding assay. Gelatin zymography for MMP-2 and -9 activities, Western blottings of MMPs, MAPKs, Src, PKC-epsilon and FAK, after [Pt(O,O'-acac)(gamma-acac)(DMS)] treatment, were also performed. Sub-cytotoxic drug concentrations decreased the: (i) anchorage-dependent and -independent growth; (ii) migration ability; and (iii) expression and activity of MMP-2 and MMP-9. [Pt(O,O'-acac)(gamma-acac)(DMS)] provoked the generation of reactive oxygen species (ROS), and the activation of p38MAPK, Src and PKC-epsilon. p38MAPK phosphorylation, cell anoikis and migration due to [Pt(O,O'-acac)(gamma-acac)(DMS)] were blocked by PKC-epsilon inhibition. Furthermore, Src inhibition blocked the [Pt(O,O'-acac)(gamma-acac)(DMS)]-provoked activation of PKC-epsilon, while ROS generation blockage inhibited the activation of Src, and also the decrement of phosphorylated FAK observed in detached [Pt(O,O'-acac)(gamma-acac)(DMS)]-treated cells. Sublethal concentrations of [Pt(O,O'-acac)(gamma-acac)(DMS)] induced anoikis and prevented events leading to metastasis via alterations in cell migration, anchorage independency, stromal interactions and MMP activity. Hence, [Pt(O,O'-acac)(gamma-acac)(DMS)] may be a promising therapeutic agent for preventing growth and metastasis of breast cancer.

Effectiveness of nickel-titanium springs vs elastomeric chains in orthodontic space closure: A systematic review and meta-analysis.

Science.gov (United States)

Mohammed, H; Rizk, M Z; Wafaie, K; Almuzian, M

2018-02-01

The aim of this study is to explore the effectiveness of nickel titanium closing springs (NiTi-CS) and elastomeric power chains (EPC) in orthodontic space closure and to assess the adverse periodontal effects, cost efficiency and patient-centred outcomes between both of these methods. An electronic search of online databases (Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, EMBASE, Scopus, LILACS and Web of Science), reference lists and grey literature as well as hand search were conducted without language restriction up to November/2017. Two authors blindly and in duplicate were involved in study selection, quality assessment and the extraction of data. Only randomized clinical trials (RCTs) were included. The quality of the studies was assessed using the Cochrane Collaboration's risk of bias tool. 95% confidence intervals and mean difference for continuous data were calculated. A meta-analysis that generated a random-effect model for the comparable outcomes was conducted, and heterogeneity was measured using I 2 statistic. Of 187 records, 4 RCTs met the criteria and were included in the quantitative synthesis featuring 290 test quadrants. Faster space closure with NiTi-CS was observed with a mean difference of (0.20 mm/month, 95% CI: 0.12 to 0.28). Loss of anchorage appears to be similar within both groups when synthesized qualitatively. With exception to anchorage loss, secondary outcomes could not be investigated in the included trials. There is a moderate quality of evidence suggesting a faster orthodontic space closure with the NiTi-CS when compared to EPC. A comparable amount of anchorage loss was observed regardless of the utilized method of space closure. Further high-quality RCTs with parallel-groups, reporting on the adverse effects and patient-centred values, are recommended. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Induction of miR-137 by Isorhapontigenin (ISO) Directly Targets Sp1 Protein Translation and Mediates Its Anticancer Activity Both In Vitro and In Vivo.

Science.gov (United States)

Zeng, Xingruo; Xu, Zhou; Gu, Jiayan; Huang, Haishan; Gao, Guangxun; Zhang, Xiaoru; Li, Jingxia; Jin, Honglei; Jiang, Guosong; Sun, Hong; Huang, Chuanshu

2016-03-01

Our recent studies found that isorhapontigenin (ISO) showed a significant inhibitory effect on human bladder cancer cell growth, accompanied with cell-cycle G0-G1 arrest as well as downregulation of Cyclin D1 expression at transcriptional level via inhibition of Sp1 transactivation in bladder cancer cells. In the current study, the potential ISO inhibition of bladder tumor formation has been explored in a xenograft nude mouse model, and the molecular mechanisms underlying ISO inhibition of Sp1 expression and anticancer activities have been elucidated both in vitro and in vivo. Moreover, the studies demonstrated that ISO treatment induced the expression of miR-137, which in turn suppressed Sp1 protein translation by directly targeting Sp1 mRNA 3'-untranslated region (UTR). Similar to ISO treatment, ectopic expression of miR-137 alone led to G0-G1 cell growth arrest and inhibition of anchorage-independent growth in human bladder cancer cells, which could be completely reversed by overexpression of GFP-Sp1. The inhibition of miR-137 expression attenuated ISO-induced inhibition of Sp1/Cyclin D1 expression, induction of G0-G1 cell growth arrest, and suppression of cell anchorage-independent growth. Taken together, our studies have demonstrated that miR-137 induction by ISO targets Sp1 mRNA 3'-UTR and inhibits Sp1 protein translation, which consequently results in reduction of Cyclin D1 expression, induction of G0-G1 growth arrest, and inhibition of anchorage-independent growth in vitro and in vivo. Our results have provided novel insights into understanding the anticancer activity of ISO in the therapy of human bladder cancer. ©2016 American Association for Cancer Research.

Animal experiment of periodontal tissue remodeling in application of ...

African Journals Online (AJOL)

The aim of the present study is to observe the remodeling of periodontal tissue in application of miniimplant anchorage for incisor intrusion in dogs. Six adult male beagle dogs were used for the experiment. On the buccal site, a mini-implant was placed at the interalveolar septum between the maxillary second incisor and ...

29 CFR Appendix B to Subpart I of... - General Testing Conditions and Additional Guidelines for Personal Fall Protection Systems (Non...

Science.gov (United States)

2010-07-01

..., to its hanging location (6 feet (1.83 m) below the anchorage). The test weight should fall without... belts, the complete belt should withstand a drop test consisting of a 250 pound (113.4 kg) weight.... One belt terminal should be attached to a rigid anchor and the other terminal should hang free. The...

Pyrvinium targets the unfolded protein response to hypoglycemia and its anti-tumor activity is enhanced by combination therapy.

Directory of Open Access Journals (Sweden)

De-Hua Yu

Full Text Available We identified pyrvinium pamoate, an old anthelminthic medicine, which preferentially inhibits anchorage-independent growth of cancer cells over anchorage-dependent growth (approximately 10 fold. It was also reported by others to have anti-tumor activity in vivo and selective toxicity against cancer cells under glucose starvation in vitro, but with unknown mechanism. Here, we provide evidence that pyrvinium suppresses the transcriptional activation of GRP78 and GRP94 induced by glucose deprivation or 2-deoxyglucose (2DG, a glycolysis inhibitor, but not by tunicamycin or A23187. Other UPR pathways induced by glucose starvation, e.g. XBP-1, ATF4, were also found suppressed by pyrvinium. Constitutive expression of GRP78 via transgene partially protected cells from pyrvinium induced cell death under glucose starvation, suggesting that suppression of the UPR is involved in pyrvinium mediated cytotoxicity under glucose starvation. Xenograft experiments showed rather marginal overall anti-tumor activity for pyrvinium as a monotherapy. However, the combination of pyrvinium and Doxorubicin demonstrated significantly enhanced efficacy in vivo, supporting a mechanistic treatment concept based on tumor hypoglycemia and UPR.

Weatherization Apprenticeship Program

Energy Technology Data Exchange (ETDEWEB)

Watson, Eric J

2012-12-18

Weatherization improvement services will be provided to Native people by Native people. The proposed project will recruit, train and hire two full-time weatherization technicians who will improve the energy efficiency of homes of Alaska Natives/American Indians residing in the Indian areas, within the Cook Inlet Region of Alaska. The Region includes Anchorage as well as 8 small tribal villages: The Native Villages of Eklutna, Knik, Chickaloon, Seldovia, Ninilchik, Kenaitze, Salamatof, and Tyonek. This project will be a partnership between three entities, with Cook Inlet Tribal Council (CITC) as the lead agency: CITCA's Employment and Training Services Department, Cook Inlet Housing Authority and Alaska Works Partnership. Additionally, six of the eight tribal villages within the Cook Inlet Region of Alaska have agreed to work with the project in order to improve the energy efficiency of their tribally owned buildings and homes. The remaining three villages will be invited to participate in the establishment of an intertribal consortium through this project. Tribal homes and buildings within Anchorage fall under Cook Inlet Region, Inc. (CIRI) tribal authority.

Role of DNA lesions and repair in the transformation of human cells

International Nuclear Information System (INIS)

Maher, V.M.; McCormick, J.J.

1987-01-01

Results of studies on the transformation of diploid human fibroblasts in culture into tumor-forming cells by exposure to chemical carcinogens or radiation indicate that such transformation is multi-stepped process that at least one step, acquisition of anchorage independence, occurs as a mutagenic event. Studies comparing normal-repairing human cells with DNA repair-deficient cells, such as those derived from cancer-prone xeroderma pigmentosum patients, indicate that excision repair in human fibroblasts is essentially an error-free process that the ability to excise potentially cytotoxic, mutagenic, or transforming lesions induced DNA by carcinogens determines their ultimate biological consequences. Cells deficient in excision repair are abnormally sensitive to these agents. Studies with cells treated at various times in the cell cycle show that there is a certain limited amount of time available for DNA repair between the initial exposure and the onset of the cellular event responsible for mutation induction and transformation to anchorage independence. The data suggest that DNA replication on a template containing unexcised lesions (photoproducts, adducts) is the critical event

Menadione (Vitamin K3) induces apoptosis of human oral cancer cells and reduces their metastatic potential by modulating the expression of epithelial to mesenchymal transition markers and inhibiting migration.

Science.gov (United States)

Suresh, Shruthy; Raghu, Dinesh; Karunagaran, Devarajan

2013-01-01

Oral cancer is one of the most commonly occurring cancers worldwide, decreasing the patient's survival rate due to tumor recurrence and metastasis. Menadione (Vitamin K3) is known to exhibit cytotoxicity in various cancer cells but the present study focused on its effects on viability, apoptosis, epithelial to mesenchymal transition (EMT), anchorage independent growth and migration of oral cancer cells. The results show that menadione is more cytotoxic to SAS (oral squamous carcinoma) cells but not to non-tumorigenic HEK293 and HaCaT cells. Menadione treatment increased the expression of pro-apoptotic proteins, Bax and p53, with a concurrent decrease in anti-apoptotic proteins, Bcl-2 and p65. Menadione induced the expression of E-cadherin but reduced the expression of EMT markers, vimentin and fibronectin. Menadione also inhibited anchorage independent growth and migration in SAS cells. These findings reveal and confirm that menadione is a potential candidate in oral cancer therapy as it exhibits cytotoxic, antineoplastic and antimigratory effects besides effectively blocking EMT in oral cancer cells.

Critical factors for the success of orthodontic mini-implants: a systematic review.

Science.gov (United States)

Chen, Yan; Kyung, Hee Moon; Zhao, Wen Ting; Yu, Won Jae

2009-03-01

This systematic review was undertaken to discuss factors that affect mini-implants as direct and indirect orthodontic anchorage. The data were collected from electronic databases (Medline [Entrez PubMed], Embase, Web of Science, Cochrane Library, and All Evidence Based Medicine Reviews). Randomized clinical trials, prospective and retrospective clinical studies, and clinical trials concerning the properties, affective factors, and requirements of mini-implants were considered. The titles and abstracts that appeared to fulfill the initial selection criteria were collected by consensus, and the original articles were retrieved and evaluated with a methodologic checklist. A hand search of key orthodontic journals was performed to identify recent unindexed literature. The search strategy resulted in 596 articles. By screening titles and abstracts, 126 articles were identified. After the exclusion criteria were applied, 16 articles remained. The analyzed results of the literature were divided into 2 topics: placement-related and loading-related factors. Mini-implants are effective as anchorage, and their success depends on proper initial mechanical stability and loading quality and quantity.

[Comparative evaluation of two kinds of micro-implant system with different size].

Science.gov (United States)

Wang, Zhen-Dong; Li, Qing-Yi; Wang, Lin; Gu, Yong-Jia

2009-04-01

To offer some reference for micro-implant's development and population by analyzing clinical application of two kinds of micro-implant systems. 38 patients treated with MIA (micro-implant anchorage) and 28 patients treated with SDIA (self-driven titanium implant for orthodontic anchorage) were included. Analyzing the rate of lost implants, the gum's reactivity and the efficiency of moving teeth summarized the excellences and shortcomings of two systems. 1) Six of MIA implants fell off after being inserted. Seven of SDIA implants lost when they had been implanted for a month. But they were stable after being inserted again. 2) The gum around 12 SDIA implants got inflammation symptom, but the gum around MIA implants was normal. 3) Both MIA implants and SDIA implants could move teeth effectively and persistently when they were stable. When we apply micro-implant in clinic, we should prevent it from closing roots of teeth and choose the small tip micro-implant. The embedded position should be in area of attachment gum. At the same time, the areas around the tip of micro-implant should be keeping clean.

Successful treatment of multiple bilateral impactions - a case report.

Science.gov (United States)

Schubert, Michael; Proff, Peter; Kirschneck, Christian

2016-07-25

Successful treatment of patients with multiple bilateral impactions can be an orthodontic challenge, but few reports on treatment planning and execution exist. In this case report, we describe the successful orthodontic treatment of a 16.3-year old female patient without systemic or genetic disease with initially nine persisting deciduous and nine impacted permanent teeth with complete root formation and closed apices in both jaws. After extraction of the deciduous and surgical exposure of the impacted permanent teeth, the Easy-Way-Coil™ system was used in conjunction with a skeletal anchorage (maxilla, BENEfit™ system) to guide the eruption of all impacted teeth. After a total treatment time of only 22.8 months all impacted teeth could be aligned successfully and a stable and functional class I occlusion was achieved. In addition, there were no adverse treatment effects such as anchorage loss, root resorptions or periodontal problems and an esthetic result could be achieved. The presented treatment approach thus proved to be highly effective in cases with multiple bilateral impactions with minimal side effects and considerably reduced treatment time.

75 FR 7039 - Investigations Regarding Certifications of Eligibility to Apply for Worker Adjustment Assistance

Science.gov (United States)

2010-02-16

... Chevron North America Anchorage, AK......... 01/11/10 01/07/10 Exploration and Production (State). 73241... 01/12/10 (State). 73260 Supplier Link Services Fremont, CA 01/13/10 01/12/10 (State). 73261 Toyota..., WI 01/14/10 01/13/10 73287 Electronic Data Systems Fort Worth, TX........ 01/14/10 01/12/10 (EDS...

Estimating consumer willingness to pay a price premium for Alaska secondary wood products.

Science.gov (United States)

Geoffrey H. Donovan; David L. Nicholls

2003-01-01

Dichotomous choice contingent valuation survey techniques were used to estimate mean willingness to pay (WTP) a price premium for made-in-Alaska secondary wood products. Respondents were asked to compare two superficially identical end tables, one made in China and one made in Alaska. The surveys were administered at home shows in Anchorage, Fairbanks, and Sitka in...

Sources of product information used by consumers when purchasing kitchen cabinets.

Science.gov (United States)

Geoffrey H. Donovan; David L. Nicholls; Joseph. Roos

2004-01-01

Survey data from home shows in Seattle, Washington and Anchorage, Alaska were used to determine the sources of product information used by consumers when buying kitchen cabinets. Results show that in-store sales staff are the most common source of product information, and that consumers' favorite wood species, age, and gender can influence the source of product...

Wood energy for residential heating in Alaska: current conditions, attitudes, and expected use

Science.gov (United States)

David L. Nicholls; Allen M. Brackley; Valerie. Barber

2010-01-01

This study considered three aspects of residential wood energy use in Alaska: current conditions and fuel consumption, knowledge and attitudes, and future use and conditions. We found that heating oil was the primary fuel for home heating in southeast and interior Alaska, whereas natural gas was used most often in south-central Alaska (Anchorage). Firewood heating...

Analysis and discussion on several problems when testing the thickness of reinforcement cover of concrete component

Science.gov (United States)

Zhanhua, Zhang; Guiling, Ji; Lijie; Zhaobo, Zhang; Na, Han; Jing, Zhao; Tan, Li; Zhaorui, Liu

2018-03-01

Reinforcement cover of concrete component plays a very important role to ensure the durability of various types of structures and the effective anchorage between steel reinforcement and concrete. This paper discusses and analyzes the problems occurred when testing the thickness of reinforcement cover of concrete component, so as to provide reference and help for related work.

Growing pressures on Circumpolar North wilderness: A case for coordinated research and education

Science.gov (United States)

Lilian Alessa; Alan Watson

2002-01-01

Pressures are growing on undeveloped (wild) places in the Circumpolar North. Among them are economic development, oil and gas exploration and extraction, development of geothermal energy resources, development of heavy industry close to energy sources, and lack of appreciation for “other” orientations toward wilderness resources. An international seminar in Anchorage,...

Report of a Class I bimaxillary dental protrusion case with extraction of first premolars treated with Clarity™ SL MBT appliances

Directory of Open Access Journals (Sweden)

Hugo Trevisi

2013-01-01

Full Text Available Bimaxillary protrusion cases are common in orthodontic practice. For the best facial outcome, the biomechanics can often be challenging. A class I bimaxillary protrusion case is presented below illustrating the careful application of extractions and bracket prescription. The case highlights how self-ligating brackets and high precision bracket positioning can reduce the need for additional anchorage.

33 CFR 110.194a - Mobile Bay, Ala., and Mississippi Sound, Miss.

Science.gov (United States)

2010-07-01

... Sound, Miss. 110.194a Section 110.194a Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF... Mississippi Sound, Miss. (a) The anchorage grounds. (1) The waters of lower Mobile Bay, near Cedar Point... south by latitude 30°20′00″, and on the west by longitude 88°06′00″. (2) The waters of Mississippi Sound...

78 FR 21861 - Tribal Consultation on the Draft Regulations Governing the Tribal Transportation Program

Science.gov (United States)

2013-04-12

... Welcome and Introductions. 9:15 a.m.-9:30 a.m Brief history of 25 CFR part 170 and process for updating... following dates, at the following locations: Meeting date Location Time May 14, 2013 Anchorage, AK 9 a.m.-4... result of the enactment of SAFETEA-LU but the regulation was not revised at that time. MAP-21 effectively...

Quantitative assessment of palatal bone thickness in an ethnic Indian population: A computed tomography study

Directory of Open Access Journals (Sweden)

Ganesan Jayakumar

2012-01-01

Conclusions: Despite the palatal bone being thickest in the mid-palatal suture (MPS region, this is not the ideal site for anchorage purposes due to inadequate calcification and interposition of connective tissue, especially in young growing children. So, the alternate optimum position is the paramedian region, 3 mm lateral to the MPS and 4 mm from the incisive foramen (IF.

Twin - Arch technique. Revival of the "edgewise -Technique"?

Directory of Open Access Journals (Sweden)

Jacob Karp

2012-01-01

The SNB – Bracket brings a new dimension into the orthodontic world which is most apparent in extraction cases. Its Teflon – like material has a very low friction coefficient thus, reducing the treatment time considerably. Through the use of low dimensioned arch wires, the Twin – Arch Technique becomes a Light – wire system and simultaneously provides good anchorage and torque control.

Quantitative radioimmunoassay for membranous and soluble H-Y antigen typing

Energy Technology Data Exchange (ETDEWEB)

Casanova-Bettane, M.; Latron, F.; Jakob, H.; Fellous, M.

1981-01-01

Two sensitive and quantitative methods for membranous or soluble H-Y antigen typing using rat anti-H-Y immune sera and /sup 125/I labelled protein A were carried out. These techniques were used to study H-Y antigen expression in human cell lines, and to refine the hypothesis that ..beta../sub 2/m serves as an anchorage point for H-Y antigen.

78 FR 12033 - Programs and Research Projects Affecting the Arctic

Science.gov (United States)

2013-02-21

..., Alaska, on March 21-22, 2013. The business sessions, open to the public, will convene at 8:30 a.m. in Anchorage and reconvene in the afternoon in Bethel on March 21. The commission will meet again at 8:30 a.m. on March 22 in Bethel. The Agenda items include: (1) Call to order and approval of the agenda (2...

2016 NOAA NGS Ortho-rectified Color Mosaic of Anchorage, Alaska

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains ortho-rectified mosaic tiles, created as a product from the NOAA Integrated Ocean and Coastal Mapping (IOCM) initiative. The source imagery...

77 FR 22489 - Special Anchorage Regulations, Newport Bay Harbor, CA

Science.gov (United States)

2012-04-16

... convenience of the reader we have included references pertaining to local municipal codes in the rule..., design, or operation; test methods; sampling procedures; and related management systems practices) that...

Tissue reaction surrounding miniscrews for orthodontic anchorage: An animal experiment

Directory of Open Access Journals (Sweden)

Stephanie Shih-Hsuan Chen

2012-03-01

Results and conclusions: (1 Tissue surrounding roots damaged by a miniscrew showed a significant inflammatory response. (2 Root resorption was occasionally observed after 3 weeks following insertion of a miniscrew even if the miniscrew was not in direct contact with the root. (3 Root repair was noted with a cementoblast lining along the resorption surface at as early as 3 weeks after miniscrew insertion. Alveolar bone filled in the lesion when the root damage was large so that the contour of the alveolar bone followed that of the damaged root, with the width of the periodontal ligament space being maintained. (4 Stable miniscrews were mainly those which did not contact adjacent roots, and for which the surrounding tissue showed only a small inflammatory response with some extent of direct bone contact around the miniscrew. On the contrary, most of the failed miniscrews were those which had direct contact with adjacent roots, and which exhibited severe tissue inflammation and were covered by thick layers of soft tissue. Failure was detected 3 weeks after insertion. Surprisingly, the epithelial lining surrounding the miniscrews might not have spontaneously resolved 6 weeks after screw removal. Persistent infection in the sinus tract was noted, and this would require attention.

Experimental Study on Bond-Slip Behavior of Bamboo Bolt-Modified Slurry Interface under Pull-Out Load

Directory of Open Access Journals (Sweden)

Wei Lu

2018-01-01

Full Text Available This paper presents an analysis of bamboo bolt-modified slurry interfaces based on 26 in situ axial pull-out tests intended to highlight the mechanical behavior of interface under a fracture mode. Three impact factors are analyzed: anchorage length, bolt diameter, and bolt hole diameter, using the same materials of bamboo and modified slurry. The result shows that the interface between the bamboo bolt and anchoring agent is the control interface of an anchorage system, and the local behavior of the interface involves four stages: elastic, soften, friction, and decoupling. Distribution law and change trend of slippage, stress, and strain of anchoring interface along with the axial direction of an anchor bolt were analyzed. The result shows that there is effective anchoring length limit in this kind of interface, and that the complete decoupling phenomenon should not be neglected. Through a comparative analysis of the existing bond-slip model and interface bond-slip curve, and considering the correspondence of the strain-slip curve and trilinear bond-slip model simultaneously, a modified trilinear bond-slip model has been proposed. The friction section of this model is limited, and shearing stress in the complete decoupling section is zero.

Suppression of progranulin expression inhibits bladder cancer growth and sensitizes cancer cells to cisplatin.

Science.gov (United States)

Buraschi, Simone; Xu, Shi-Qiong; Stefanello, Manuela; Moskalev, Igor; Morcavallo, Alaide; Genua, Marco; Tanimoto, Ryuta; Birbe, Ruth; Peiper, Stephen C; Gomella, Leonard G; Belfiore, Antonino; Black, Peter C; Iozzo, Renato V; Morrione, Andrea

2016-06-28

We have recently demonstrated a critical role for progranulin in bladder cancer. Progranulin contributes, as an autocrine growth factor, to the transformed phenotype by modulating Akt-and MAPK-driven motility, invasion and anchorage-independent growth. Progranulin also induces F-actin remodeling by interacting with the F-actin binding protein drebrin. In addition, progranulin is overexpressed in invasive bladder cancer compared to normal tissue controls, suggesting that progranulin might play a key role in driving the transition to the invasive phenotype of urothelial cancer. However, it is not established whether targeting progranulin could have therapeutic effects on bladder cancer. In this study, we stably depleted urothelial cancer cells of endogenous progranulin by shRNA approaches and determined that progranulin depletion severely inhibited the ability of tumorigenic urothelial cancer cells to migrate, invade and grow in anchorage-independency. We further demonstrate that progranulin expression is critical for tumor growth in vivo, in both xenograft and orthotopic tumor models. Notably, progranulin levels correlated with response to cisplatin treatment and were upregulated in bladder tumors. Our data indicate that progranulin may constitute a novel target for therapeutic intervention in bladder tumors. In addition, progranulin may serve as a novel biomarker for bladder cancer.

Comparison between Conventional Mechanical Fixation and Use of Autologous Platelet Rich Plasma (PRP) in Wound Beds Prior to Resurfacing with Split Thickness Skin Graft.

Science.gov (United States)

P Waiker, Veena; Shivalingappa, Shanthakumar

2015-01-01

Platelet rich plasma is known for its hemostatic, adhesive and healing properties in view of the multiple growth factors released from the platelets to the site of wound. The primary objective of this study was to use autologous platelet rich plasma (PRP) in wound beds for anchorage of skin grafts instead of conventional methods like sutures, staplers or glue. In a single center based randomized controlled prospective study of nine months duration, 200 patients with wounds were divided into two equal groups. Autologous PRP was applied on wound beds in PRP group and conventional methods like staples/sutures used to anchor the skin grafts in a control group. Instant graft adherence to wound bed was statistically significant in the PRP group. Time of first post-graft inspection was delayed, and hematoma, graft edema, discharge from graft site, frequency of dressings and duration of stay in plastic surgery unit were significantly less in the PRP group. Autologous PRP ensured instant skin graft adherence to wound bed in comparison to conventional methods of anchorage. Hence, we recommend the use of autologous PRP routinely on wounds prior to resurfacing to ensure the benefits of early healing.

A genetic discontinuity in moose (Alces alces) in Alaska corresponds with fenced transportation infrastructure

Science.gov (United States)

Wilson, Robert E.; Farley, Sean D.; McDonough, Thomas J.; Talbot, Sandra L.; Barboza, Perry S.

2015-01-01

The strength and arrangement of movement barriers can impact the connectivity among habitat patches. Anthropogenic barriers (e.g. roads) are a source of habitat fragmentation that can disrupt these resource networks and can have an influence on the spatial genetic structure of populations. Using microsatellite data, we evaluated whether observed genetic structure of moose (Alces alces) populations were associated with human activities (e.g. roads) in the urban habitat of Anchorage and rural habitat on the Kenai Peninsula, Alaska. We found evidence of a recent genetic subdivision among moose in Anchorage that corresponds to a major highway and associated infrastructure. This subdivision is most likely due to restrictions in gene flow due to alterations to the highway (e.g. moose-resistant fencing with one-way gates) and a significant increase in traffic volume over the past 30 years; genetic subdivision was not detected on the Kenai Peninsula in an area not bisected by a major highway. This study illustrates that anthropogenic barriers can substructure wildlife populations within a few generations and highlights the value of genetic assessments to determine the effects on connectivity among habitat patches in conjunction with behavioral and ecological data..

Sustainability and the Rural Education Course: is such approach possible?

Directory of Open Access Journals (Sweden)

Juliana Pereira Araújo

2017-12-01

Full Text Available The Licentiate Course in Rural Education with a degree in Nature Sciences from the Federal University of Goiás - Region Catalão was created in 2014 and since then has been facing challenges for its consolidation. Besides the implementation of a new curriculum design and the training of teacher trainers who also approach field issues, we notice from our daily practice the need to establish anchorage in concepts and theories that actually act for the benefit of the project itself in training for the field. It is in this context, from the absence of anchorages, that we carry out a reflexive study about the concept of sustainability, seeking both the understanding about it and the evaluation of the possibilities of its use as a guide to the practice or theoretical-methodological inspiration. The result of this study indicates that the concept of sustainability is more complex than it seems and requires greater understanding, however, we consider that it derives from it possibilities that should be admitted as the assumption of another role for education in the dimension of sustainable development.

Prediction of changes due to mandibular autorotation following miniplate-anchored intrusion of maxillary posterior teeth in open bite cases.

Science.gov (United States)

Kassem, Hassan E; Marzouk, Eiman S

2018-05-14

Prediction of the treatment outcome of various orthodontic procedures is an essential part of treatment planning. Using skeletal anchorage for intrusion of posterior teeth is a relatively novel procedure for the treatment of anterior open bite in long-faced subjects. Data were analyzed from lateral cephalometric radiographs of a cohort of 28 open bite adult subjects treated with intrusion of the maxillary posterior segment with zygomatic miniplate anchorage. Mean ratios and regression equations were calculated for selected variables before and after intrusion. Relative to molar intrusion, there was approximately 100% vertical change of the hard and soft tissue mention and 80% horizontal change of the hard and soft tissue pogonion. The overbite deepened two folds with 60% increase in overjet. The lower lip moved forward about 80% of the molar intrusion. Hard tissue pogonion and mention showed the strongest correlations with molar intrusion. There was a general agreement between regression equations and mean ratios at 3 mm molar intrusion. This study attempted to provide the clinician with a tool to predict the changes in key treatment variables following skeletally anchored maxillary molar intrusion and autorotation of the mandible.

Inhibition of connective tissue growth factor (CTGF/CCN2) in gallbladder cancer cells leads to decreased growth in vitro.

Science.gov (United States)

Garcia, Patricia; Leal, Pamela; Ili, Carmen; Brebi, Priscilla; Alvarez, Hector; Roa, Juan C

2013-06-01

Gallbladder cancer (GBC) is an aggressive neoplasm associated with late diagnosis, unsatisfactory treatment and poor prognosis. Previous work showed that connective tissue growth factor (CTGF) expression is increased in this malignancy. This matricellular protein plays an important role in various cellular processes and its involvement in the tumorigenesis of several human cancers has been demonstrated. However, the precise function of CTGF expression in cancer cells is yet to be determined. The aim of this study was to evaluate the CTGF expression in gallbladder cancer cell lines, and its effect on cell viability, colony formation and in vitro cell migration. CTGF expression was evaluated in seven GBC cell lines by Western blot assay. Endogenous CTGF expression was downregulated by lentiviral shRNA directed against CTGF mRNA in G-415 cells, and the effects on cell viability, anchorage-independent growth and migration was assessed by comparing them to scrambled vector-transfected cells. Knockdown of CTGF resulted in significant reduction in cell viability, colony formation and anchorage-independent growth (P cancer may confer a growth advantage for neoplastic cells. © 2013 The Authors. International Journal of Experimental Pathology © 2013 International Journal of Experimental Pathology.

Expression of activated PIK3CA in ovarian surface epithelium results in hyperplasia but not tumor formation.

Directory of Open Access Journals (Sweden)

Shun Liang

Full Text Available The Phosphatidylinositol 3'-kinase is a key regulator in various cancer-associated signal transduction pathways. Genetic alterations of its catalytic subunit alpha, PIK3CA, have been identified in ovarian cancer. Our in vivo data suggests that PIK3CA activation is one of the early genetic events in ovarian cancer. However, its role in malignant transformation of ovarian surface epithelium (OSE is largely unclear.Using the Müllerian inhibiting substance type II receptor (MISIIR promoter, we generated transgenic mice that expressed activated PIK3CA in the Müllerian epithelium. Overexpression of PIK3CA in OSE induced remarkable hyperplasia, but was not able to malignantly transform OSE in vivo. The consistent result was also observed in primary cultured OSEs. Although enforced expression of PIK3CA could not induce OSE anchorage-independent growth, it significantly increased anchorage-independent growth of OSE transformed by mutant K-ras.While PIK3CA activation may not be able to initiate OSE transformation, we conclude that activation of PIK3CA may be an important molecular event contributing to the maintenance of OSE transformation initiated by oncogenes such as K-ras.

Impact of implant design on primary stability of orthodontic mini-implants.

Science.gov (United States)

Wilmes, Benedict; Ottenstreuer, Stephanie; Su, Yu-Yu; Drescher, Dieter

2008-01-01

Skeletal anchorage with mini-implants has greatly broadened the treatment possibilities in orthodontics over the last few years. To reduce implant failure rates, it is advisable to obtain adequate primary stability. The aim of this study was to quantitatively analyze the impact of implant design and dimension on primary stability. Forty-two porcine iliac bone segments were prepared and embedded in resin. To evaluate the primary stability, we documented insertion torques of the following mini-implants: Aarhus Screw, AbsoAnchor, LOMAS, Micro-Anchorage-System, ORLUS and Spider Screw. In each bone, five Dual Top Screws were inserted for reference purposes to achieve comparability among the specimens. We observed wide variation in insertion torques and hence primary stability, depending on mini-implant design and dimension; the great impact that mini-implant diameter has on insertion torques was particularly conspicuous. Conical mini-implants achieved higher primary stabilities than cylindrical designs. The diameter and design of the mini-implant thread have a distinctive impact on primary stability. Depending on the region of insertion and local bone quality, the choice of the mini-implant design and size is crucial to establish sufficient primary stability.

Finishing occlusion in Class II or Class III molar relation: therapeutic Class II and III.

Science.gov (United States)

Nangia, A; Darendeliler, M A

2001-11-01

The most frequent extraction regime consists of the removal of upper and lower premolars. Depending on anchorage requirements, camouflage treatment options, surgical intervention, or the absence of teeth in only one arch, it may become necessary to finalize the occlusion with a one-dental-unit discrepancy between the upper and lower dental arches. Guidelines are presented for finishing occlusions in Class II or Class III molar relation.

How to achieve proper overbite—Lessons from natural dentoalveolar compensation

Directory of Open Access Journals (Sweden)

Jenny Zwei-Chieng Chang

2013-12-01

Conclusion: For orthodontically closing the open bite, intruding upper posteriors and extruding lower anteriors are appropriate ways to simulate the natural occurring compensation. To eliminate deep bite in a low mandibular plane patient, intruding upper and lower anteriors and proclining anteriors will achieve good overbite. Imitating the natural dentoalveolar compensation by using temporary anchorage devices at appropriate sites for intruding teeth helps to resolve orthodontic vertical problems.

In Vitro and In Vivo Survival and Transit Tolerance of Potentially Probiotic Strains Carried by Artichokes in the Gastrointestinal Tract

OpenAIRE

Valerio, Francesca; De Bellis, Palmira; Lonigro, Stella Lisa; Morelli, Lorenzo; Visconti, Angelo; Lavermicocca, Paola

2006-01-01

The ability of potentially probiotic strains of Lactobacillus plantarum and Lactobacillus paracasei to survive on artichokes for at least 90 days was shown. The anchorage of bacterial strains to artichokes improved their survival in simulated gastrointestinal digestion. L. paracasei IMPC2.1 was further used in an artichoke human feeding study involving four volunteers, and it was shown that the organism could be recovered from stools.

Microimplant in Lingual Tori to Correct Anterior Crossbite in Adult

Directory of Open Access Journals (Sweden)

Deepak Rai

2012-01-01

Full Text Available Anterior crossbites are difficult to correct in adults. A case where microimplants were placed in the lingual tori of an adult patient along with a lingual appliance is reported. The use of the esthetic lingual appliance along with the stable anchorage provided by the microimplants, aids in decreasing the duration of treatment as well as making the same more acceptable to the patient.

Improved monolithic reinforced concrete construction for nuclear power stations

International Nuclear Information System (INIS)

Guenther, P.; Fischer, K.

1983-01-01

Experience has shown that in applying monolithic reinforced concrete in nuclear power plant construction the following auxiliary means are useful: measuring sheets in assembling, welding gauges for reaching high tolerance accuracies of prefabricated reinforced concrete members, suitable lining materials, formwork anchorage and formwork release agents, concrete workability agents, mechanized procedures for finishing and assembling. These means were successfully tested in constructing the Greifswald nuclear power station

33 CFR 110.84b - Buffalo, N.Y.

Science.gov (United States)

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Buffalo, N.Y. 110.84b Section 110... REGULATIONS Special Anchorage Areas § 110.84b Buffalo, N.Y. The area within the Port of Buffalo known as Port of Buffalo Small Boat Harbor commencing at a point on shore at latitude 42°51′05″ N., longitude 78°51...

Comparison of Heat and Cold Stress Effects on Cardiovascular Mortality and Morbidity in Central European Urban and Rural Populations

Czech Academy of Sciences Publication Activity Database

Kyncl, J.; Urban, Aleš; Kyselý, Jan; Davídkovová, Hana; Kříž, B.

2015-01-01

Roč. 44 (2015), s. 86 ISSN 0300-5771. [IEA World Congress of Epidemiology (WCE) /20./. 17.08.2014-21.08.2014, Anchorage] R&D Projects: GA ČR(CZ) GAP209/11/1985 Institutional support: RVO:68378289 Keywords : heat stress * cold stress * Central Europe * cardiovascular mortality and morbidity Subject RIV: DG - Athmosphere Sciences, Meteorology https://wce.confex.com/wce/2014/webprogram/Paper1480.html

Orthodontic traction of a transmigrated mandibular canine using mini-implant: a case report and review.

Science.gov (United States)

Plaza, Sonia Patricia

2016-12-01

The patient in this case is an 11-year-old girl, whose mandibular left canine was transmigrated. The traction to the arch was assisted by using a temporary skeletal anchorage device. After 5 months of poor response to traction, the biomechanics were re-adjusted, obtaining effective traction in to the arch in 12 months. After this period, the treatment was completed with fixed orthodontic appliances.

Osseointegration by bone morphogenetic protein-2 and transforming growth factor beta2 coated titanium implants in femora of New Zealand white rabbits

Directory of Open Access Journals (Sweden)

Fritz Thorey

2011-01-01

Conclusions: No differences between BMP-2 alone and a combination of BMP-2+TGF-β2 could be seen in the present study. However, the results of this study confirm the results of other studies that a coating with growth factors is able to enhance bone implant ingrowth. This may be of importance in defect situations during revision surgery to support the implant ingrowth and implant anchorage.

Differential effects of miR-34c-3p and miR-34c-5p on SiHa cells proliferation apoptosis, migration and invasion

Energy Technology Data Exchange (ETDEWEB)

Lopez, Jesus Adrian [Laboratorio de Terapia Genica, Departamento de Genetica y Biologia Molecular, CINVESTAV, Av. IPN 2508, Mexico 07360 D.F. (Mexico); Alvarez-Salas, Luis Marat, E-mail: lalvarez@cinvestav.mx [Laboratorio de Terapia Genica, Departamento de Genetica y Biologia Molecular, CINVESTAV, Av. IPN 2508, Mexico 07360 D.F. (Mexico)

2011-06-10

Highlights: {yields} In this study we examine miR-34c-3p and miR-34c-5p functions in SiHa cells. {yields} We study miRNA effect on cell proliferation, anchorage independent growth, apoptosis, cell motility and invasion. {yields} We find that miR-34c-3p and miR-34c-5p inhibition of proliferation and anchorage independent growth are exclusive to SiHa cells. {yields} miR-34c-3p induces apoptosis and inhibits cell motility and invasion in SiHa cells. {yields} In this study we conclude that miR-34c-3p functions as a tumor suppressor differ from miR-34c-5p. -- Abstract: MicroRNAs (miRNA) regulate expression of several genes associated with human cancer. Here, we analyzed the function of miR-34c, an effector of p53, in cervical carcinoma cells. Expression of either miR-34c-3p or miR-34c-5p mimics caused inhibition of cell proliferation in the HPV-containing SiHa cells but not in other cervical cells irrespective of tumorigenicity and HPV content. These results suggest that SiHa cells may lack of regulatory mechanisms for miR-34c. Monolayer proliferation results showed that miR-34c-3p produced a more pronounced inhibitory effect although both miRNAs caused inhibition of anchorage independent growth at similar extent. However, ectopic expression of pre-miR-34c-3p, but not pre-miR-34c-5p, caused S-phase arrest in SiHa cells triggering a strong dose-dependent apoptosis. A significant inhibition was observed only for miR-34c-3p on SiHa cells migration and invasion, therefore implying alternative regulatory pathways and targets. These results suggest differential tumor suppressor roles for miR-34c-3p and miR-34c-5p and provide new insights in the understanding of miRNA biology.

Rate of retraction of anterior teeth after canine distraction

Directory of Open Access Journals (Sweden)

Litesh Singla

2017-01-01

Full Text Available Background and Objectives: Orthodontists have always strived to develop a new technique to reduce the treatment time with minimal patient cooperation. Canine distraction was introduced as an alternative technique for canine retraction in a minimum possible period of 3 weeks, thus avoiding taxing the anchorage by molars since the canines are retracted within the lag phase of molars. It has been proved by numerous studies that the bone mesial to canine after rapid canine distraction through the extraction socket is a new and immature. The objectives of this study were to evaluate the rate of retraction of anterior teeth, the time taken, and anchorage loss during the retraction of anterior teeth into this newly organized bone. Methods: Six orthodontic patients who required first premolar extractions were selected. Undermining of the interseptal bone distal to the canine was done, and canines were retracted into the extraction space of the first premolar, using a custom-made tooth borne intraoral distraction screw, following which the incisors were retracted into the newly formed bone using closing loops. The patients were called at weekly intervals to measure the amount of space left between canine and lateral incisor, and the rate of retraction was calculated after space was closed. Results: The present study showed that the rate of retraction of mandibular and maxillary teeth was 0.74 ± 0.39 mm and 0.73 ± 0.15 mm/week, respectively. The anchorage loss was found to be 1.83 ± 0.29 mm and 2.08 ± 0.38 mm in mandibular and maxillary arches, respectively. The time taken to retract the incisors was found to be 40.3 ± 1.5 and 41.7 ± 0.6 days for mandibular and maxillary arches, respectively. Interpretation and Conclusion: Retraction of incisors is faster in both maxillary and mandibular arches when the incisors are retracted immediately into the immature bone created after canine distraction.

Differential effects of miR-34c-3p and miR-34c-5p on SiHa cells proliferation apoptosis, migration and invasion

International Nuclear Information System (INIS)

Lopez, Jesus Adrian; Alvarez-Salas, Luis Marat

2011-01-01

Highlights: → In this study we examine miR-34c-3p and miR-34c-5p functions in SiHa cells. → We study miRNA effect on cell proliferation, anchorage independent growth, apoptosis, cell motility and invasion. → We find that miR-34c-3p and miR-34c-5p inhibition of proliferation and anchorage independent growth are exclusive to SiHa cells. → miR-34c-3p induces apoptosis and inhibits cell motility and invasion in SiHa cells. → In this study we conclude that miR-34c-3p functions as a tumor suppressor differ from miR-34c-5p. -- Abstract: MicroRNAs (miRNA) regulate expression of several genes associated with human cancer. Here, we analyzed the function of miR-34c, an effector of p53, in cervical carcinoma cells. Expression of either miR-34c-3p or miR-34c-5p mimics caused inhibition of cell proliferation in the HPV-containing SiHa cells but not in other cervical cells irrespective of tumorigenicity and HPV content. These results suggest that SiHa cells may lack of regulatory mechanisms for miR-34c. Monolayer proliferation results showed that miR-34c-3p produced a more pronounced inhibitory effect although both miRNAs caused inhibition of anchorage independent growth at similar extent. However, ectopic expression of pre-miR-34c-3p, but not pre-miR-34c-5p, caused S-phase arrest in SiHa cells triggering a strong dose-dependent apoptosis. A significant inhibition was observed only for miR-34c-3p on SiHa cells migration and invasion, therefore implying alternative regulatory pathways and targets. These results suggest differential tumor suppressor roles for miR-34c-3p and miR-34c-5p and provide new insights in the understanding of miRNA biology.

Soldered Power Arm: An Easy and Effective Method for Intrusion and Retraction of Anterior Teeth

OpenAIRE

Ketan K Vakil; Pawankumar Dnyandeo Tekale; Jeegar K Vakil

2014-01-01

The orthodontic correction of deep overbite can be achieved with several mechanisms that will result in true intrusion of anterior teeth, extrusion of posterior teeth, or a combination of both. For the orthodontic correction of bimaxillary dentoalveolar protrusion with deep bite, there are several treatment modalities like segmented arch approach, retraction and intrusion utility arches, temporary anchorage devices. Though not a novel therapeutic concept, the use of miniscrew implants to obta...

Development of Friction Pendulum System to Reduce the Seismic Force

International Nuclear Information System (INIS)

Jang, J. B.; Kim, J. K.; Hwang, K. M.; Kwon, H. O.; Lee, C. W

2007-01-01

Most of the damages in electrical facilities are occurred at transformer due to the great earthquake. The damage types of transformer are the failure of upper bushing of transformer, overturning of transformer due to geometry with high height, and the failure of anchorage of transformer. The objective of this study is to develop the seismic isolator to prevent the damage of transformer due to earthquake considering the importance of transformer

Suppression of progranulin expression inhibits bladder cancer growth and sensitizes cancer cells to cisplatin

OpenAIRE

Buraschi, Simone; Xu, Shi-Qiong; Stefanello, Manuela; Moskalev, Igor; Morcavallo, Alaide; Genua, Marco; Tanimoto, Ryuta; Birbe, Ruth; Peiper, Stephen C.; Gomella, Leonard G.; Belfiore, Antonino; Black, Peter C.; Iozzo, Renato V.; Morrione, Andrea

2016-01-01

We have recently demonstrated a critical role for progranulin in bladder cancer. Progranulin contributes, as an autocrine growth factor, to the transformed phenotype by modulating Akt-and MAPK-driven motility, invasion and anchorage-independent growth. Progranulin also induces F-actin remodeling by interacting with the F-actin binding protein drebrin. In addition, progranulin is overexpressed in invasive bladder cancer compared to normal tissue controls, suggesting that progranulin might play...

Optimal Estimation of Glider’s Underwater Trajectory with Depth-Dependent Correction Using the Navy Coastal Ocean Model with Application to Antisubmarine Warfare

Science.gov (United States)

2014-09-01

step study. 2010 IEEE International Conf. on Robotics and Autonomation, Anchorage, Alaska, IEEE Xplore , 4770‒4777, doi:10.1109/ ROBOT.2010.5509240...Autonomation, Karlsruhe, Germany, IEEE Xplore , 5565‒5570, doi:10.1109/ ICRA.2013.6631376. Webb, D. C., P. J. Simonetti, C. P. Jones, 2001: SLOCUM: An...unmanned underwater vehicles for very shallow water mine countermeasures. Proc. OCEANS 2003, San Diego, California, IEEE , 1417‒1423. doi:10.1109

Environmental Impact Statement for the Modernization and Enhancement of Ranges, Airspace, and Training Areas in the Joint Pacific Alaska Range Complex in Alaska. Volume 2 - Appendices A through L

Science.gov (United States)

2013-06-01

Spenard Road, Anchorage, Alaska. Tuesday , January 18, 2011:6:30-8:30 p.m., Caribou Hotel, Mile 186.5 Grand Highway, Glenallen, Alaska. Wednesday...Highway, Healy, Alaska. Tuesday , january 25, 2011:6:30-8:30 p.m., Swiss Alaska Inn, 22056 South F Street, Talkeetna, Alaska. Wednesday, january...Board of Fisheries Mel Morris , Board Member, Alaska Board of Fisheries Mike Smith, Board Member, Alaska Board of Fisheries Cliff Judkins, Chair

Understanding the basis of space closure in Orthodontics for a more efficient orthodontic treatment

OpenAIRE

Ribeiro, Gerson Luiz Ulema; Jacob, Helder B.

2016-01-01

ABSTRACT Introduction: Space closure is one of the most challenging processes in Orthodontics and requires a solid comprehension of biomechanics in order to avoid undesirable side effects. Understanding the biomechanical basis of space closure better enables clinicians to determine anchorage and treatment options. In spite of the variety of appliance designs, space closure can be performed by means of friction or frictionless mechanics, and each technique has its advantages and disadvantages...

An Investigation of Corrosion Mitigation Strategies for Aging Post-Tensioned Cables

Science.gov (United States)

2017-01-01

for Aging Post- Tensioned Cables Ernest L. Miller, Barry C. White, Richard W. Haskins, Robert M. Ebeling, and James A. Evans Information Technology...approach walls) using post- tensioning (PT) seven-wire strand cables is a common approach. In the Portland District, for example, 10% of the projects...hydraulic structures by post- tensioned ground anchorage, appreciable loss of capacity in seven-wire strand cables due to corrosion is a reason for concern

An Investigation of Corrosion Mitigation Strategies for Aging Post Tensioned Cables

Science.gov (United States)

2017-01-01

for Aging Post- Tensioned Cables Ernest L. Miller, Barry C. White, Richard W. Haskins, Robert M. Ebeling, and James A. Evans Information Technology...approach walls) using post- tensioning (PT) seven-wire strand cables is a common approach. In the Portland District, for example, 10% of the projects...hydraulic structures by post- tensioned ground anchorage, appreciable loss of capacity in seven-wire strand cables due to corrosion is a reason for concern

Alterations in integrin expression modulates invasion of pancreatic cancer cells.

LENUS (Irish Health Repository)

Walsh, Naomi

2009-01-01

BACKGROUND: Factors mediating the invasion of pancreatic cancer cells through the extracellular matrix (ECM) are not fully understood. METHODS: In this study, sub-populations of the human pancreatic cancer cell line, MiaPaCa-2 were established which displayed differences in invasion, adhesion, anoikis, anchorage-independent growth and integrin expression. RESULTS: Clone #3 displayed higher invasion with less adhesion, while Clone #8 was less invasive with increased adhesion to ECM proteins compared to MiaPaCa-2. Clone #8 was more sensitive to anoikis than Clone #3 and MiaPaCa-2, and displayed low colony-forming efficiency in an anchorage-independent growth assay. Integrins beta 1, alpha 5 and alpha 6 were over-expressed in Clone #8. Using small interfering RNA (siRNA), integrin beta1 knockdown in Clone #8 cells increased invasion through matrigel and fibronectin, increased motility, decreased adhesion and anoikis. Integrin alpha 5 and alpha 6 knockdown also resulted in increased motility, invasion through matrigel and decreased adhesion. CONCLUSION: Our results suggest that altered expression of integrins interacting with different extracellular matrixes may play a significant role in suppressing the aggressive invasive phenotype. Analysis of these clonal populations of MiaPaCa-2 provides a model for investigations into the invasive properties of pancreatic carcinoma.

A novel role for drebrin in regulating progranulin bioactivity in bladder cancer.

Science.gov (United States)

Xu, Shi-Qiong; Buraschi, Simone; Morcavallo, Alaide; Genua, Marco; Shirao, Tomoaki; Peiper, Stephen C; Gomella, Leonard G; Birbe, Ruth; Belfiore, Antonino; Iozzo, Renato V; Morrione, Andrea

2015-05-10

We recently established a critical role for the growth factor progranulin in bladder cancer insofar as progranulin promotes urothelial cancer cell motility and contributes, as an autocrine growth factor, to the transformed phenotype by modulating invasion and anchorage-independent growth. In addition, progranulin expression is upregulated in invasive bladder cancer tissues compared to normal controls. However, the molecular mechanisms of progranulin action in bladder cancer have not been fully elucidated. In this study, we searched for novel progranulin-interacting proteins using pull-down assays with recombinant progranulin and proteomics. We discovered that drebrin, an F-actin binding protein, bound progranulin in urothelial cancer cells. We characterized drebrin function in urothelial cancer cell lines and showed that drebrin is critical for progranulin-dependent activation of the Akt and MAPK pathways and modulates motility, invasion and anchorage-independent growth. In addition, drebrin regulates tumor formation in vivo and its expression is upregulated in bladder cancer tissues compared to normal tissue controls. Our data are translationally relevant as indicate that drebrin exerts an essential functional role in the regulation of progranulin action and may constitute a novel target for therapeutic intervention in bladder tumors. In addition, drebrin may serve as novel biomarker for bladder cancer.

differentiation in agritourism ventures of a Group of Rural Change (INTA in Coronel Suárez (Buenos Aires

Directory of Open Access Journals (Sweden)

Marina Cordisco

2013-12-01

Full Text Available From the converged concepts identity, culture, heritage and territory, is analyzed the possibility of formulating and implementing a strategy of differentiation for the agritourism activity developed by farms of group Cortaderas II (Cambio Rural, INTA, in Coronel Suárez (province of Buenos Aires. With this aim was made a diagnostic through direct interviews and observations of the farms involved. Emphasizing own aspects of its rural environment, was tried to identify cultural values and products with territorial anchorage that they impose a distinctive stamp to the tourist service that they offer. In addition, was investigated in what measure the members are prepared to manage the business, recognizing in them managerial competitions and enterprising characteristics. Finally, it is thought over brings over of the degree of maturity reached, typifying the individual enterprise culture and according to the group work, of way of evaluating if the putting in value of its resources evolves from a " domestic character " up to coming to a " commercial formal character ". It is observed the construction of a socio- cultural-economic identity that makes viable a competitive differential strategy with anchorage in the territory, as well as conditions for the development of the most formalized tourist activity based on the quality management

Human cell transformation in the study of sunlight-induced cancers in the skin of man

International Nuclear Information System (INIS)

Sutherland, B.M.; Bennett, P.V.

1988-01-01

Human cell transformation provides a powerful approach to understanding - at the cellular and molecular levels - induction of cancers in the skin of man. A principal approach to this problem is the direct transformation of human skin cells by exposure to ultraviolet and/or near-UV radiation. The frequency of human cells transformed to anchorage independence increases with radiation exposure; the relative transforming efficiencies of different wavelengths implies that direct absorption by nucleic acids is a primary initial event. Partial reversal of potential transforming lesions by photoreactivation suggests that pyrimidine dimers, as well as other lesions, are important in UV transformation of human cells. Human cells can also be transformed by transfection with cloned oncogenes, or with DNAs from tumors or tumor cell lines. Cells treated by the transfection procedure (but without DNA) or cells transfected with DNAs from normal mammalian cells or tissues show only background levels of transformation. Human cells can be transformed to anchorage-independent growth by DNAs ineffective in transformation of NIH 3T3 cells (including most human skin cancers), permitting the analysis of oncogenic molecular changes even in tumor DNAs difficult or impossible to analyze in rodent cell systems. 29 refs.; 4 figs.; 1 table

The Experimental Study of the Temperature Effect on the Interfacial Properties of Fully Grouted Rock Bolt

Directory of Open Access Journals (Sweden)

Fuhai Li

2017-03-01

Full Text Available This study analyzes the phenomenon of performance deterioration in fully grouted rock bolts in tunnels with a dry, hot environment and high geothermal activity with a focus on temperature effects on interfacial bond performance. Three groups of fully grouted rock bolt specimens were designed based on similar mechanical principles. They were produced and maintained at 20 °C, 35 °C, and 50 °C. Through the indoor gradual loading tensile test of specimens, variations of axial force and shear stress between the rock bolt and mortar adhesive interface were obtained under different environmental temperatures. Distribution of the axial force and shear stress on the anchorage section were found under different tensile forces. Results showed that, with an increase in specimen environmental temperature, maximum shear stress of the rock bolt section became smaller, while shear stress distribution along the rock bolt segment became more uniform. In addition, the axial force value at the same position along the pull end was greater, while axial stress along the anchorage’s length decayed faster. With an increase in tensile force under different temperatures, the axial force and maximum shear stress of rock bolt specimens along the anchorage section has a corresponding increase.

Tumor-promoting function and prognostic significance of the RNA-binding protein T-cell intracellular antigen-1 in esophageal squamous cell carcinoma.

Science.gov (United States)

Hamada, Junichi; Shoda, Katsutoshi; Masuda, Kiyoshi; Fujita, Yuji; Naruto, Takuya; Kohmoto, Tomohiro; Miyakami, Yuko; Watanabe, Miki; Kudo, Yasusei; Fujiwara, Hitoshi; Ichikawa, Daisuke; Otsuji, Eigo; Imoto, Issei

2016-03-29

T-cell intracellular antigen-1 (TIA1) is an RNA-binding protein involved in many regulatory aspects of mRNA metabolism. Here, we report previously unknown tumor-promoting activity of TIA1, which seems to be associated with its isoform-specific molecular distribution and regulation of a set of cancer-related transcripts, in esophageal squamous cell carcinoma (ESCC). Immunohistochemical overexpression of TIA1 ectopically localized in the cytoplasm of tumor cells was an independent prognosticator for worse overall survival in a cohort of 143 ESCC patients. Knockdown of TIA1 inhibited proliferation of ESCC cells. By exogenously introducing each of two major isoforms, TIA1a and TIA1b, only TIA1a, which was localized to both the nucleus and cytoplasm, promoted anchorage-dependent and anchorage-independent ESCC cell proliferation. Ribonucleoprotein immunoprecipitation, followed by microarray analysis or massive-parallel sequencing, identified a set of TIA1-binding mRNAs, including SKP2 and CCNA2. TIA1 increased SKP2 and CCNA2 protein levels through the suppression of mRNA decay and translational induction, respectively. Our findings uncover a novel oncogenic function of TIA1 in esophageal tumorigenesis, and implicate its use as a marker for prognostic evaluation and as a therapeutic target in ESCC.

Mini-implants in the palatal slope – a retrospective analysis of implant survival and tissue reaction

Directory of Open Access Journals (Sweden)

Ziebura Thomas

2012-11-01

Full Text Available Abstract Background To identify insertion procedure and force application related complications in Jet Screw (JS type mini-implants when inserted in the palatal slope. Methods Setting and Sample Population: The Department of Orthodontics, the University Hospital Münster. Forty-one consecutively started patients treated using mini-implants in the palatal slope. In this retrospective study, 66 JS were evaluated. Patient records were used to obtain data on the mode of utilization and complications. Standardized photographs overlayed with a virtual grid served to test the hypothesis that deviations from the recommended insertion site or the type of mechanics applied might be related to complications regarding bleeding, gingival overgrowth or implant failure. Results Two implants (3% were lost, and two implants (3%, both loaded with a laterally directed force, exhibited loosening while still serving for anchorage. Complications that required treatment did not occur, the most severe problem observed being gingival proliferation which was attributable neither to patients’ age nor to applied mechanics or deviations from the ideal implant position. Conclusions The JS mini-implant is reliable for sagittal and vertical movements or anchorage purposes. Laterally directed forces might be unfavorable. The selection of implant length as well as the insertion procedure should account for the possibility of gingival overgrowth.

The efficacy of short (6 mm) dental implants with a novel thread design.

Science.gov (United States)

Bechara, Soheil; Nimčenko, Tatjana; Kubilius, Ričardas

2017-01-01

To assess efficacy of short (6 mm) implants with a novel macrostructure and thread design placed in a compromised bone situations of edentulous posterior regions of maxilla (3-4 mm of bone height under sinus floor) as compared to results of clinical situations treated with simultaneous maxillary sinus grafting and placement of long (≥10 mm) implants of the same company. Clinical cases of conducted clinical study. Patients with compromised bone height in edentulous posterior regions of maxilla were randomly divided into two groups. Short (6mm length) implant treatment conducted in the test group and simultaneous sinus lift with standard length implant placement treatment in the control group. In general implant stability quotient (ISQ) and marginal bone level (MBL) changes values in both groups were comparable. However, significant negative correlation was found between implant's diameter and MBL changes. Implant's length has little if none impact on initial implant anchorage, especially in greatly compromised residual bone situations. Results have confirmed that implant initial stability mainly depends on implant's macro-design and further its development on implant's micro-design: namely, implant diameter rather than length, tapered shape and improved thread design determines primarily acquired mechanical anchorage, while bioactive surface treatment ensures development of biological stability.

RhoG regulates anoikis through a phosphatidylinositol 3-kinase-dependent mechanism

International Nuclear Information System (INIS)

Yamaki, Nao; Negishi, Manabu; Katoh, Hironori

2007-01-01

In normal epithelial cells, cell-matrix interaction is required for cell survival and proliferation, whereas disruption of this interaction causes epithelial cells to undergo apoptosis called anoikis. Here we show that the small GTPase RhoG plays an important role in the regulation of anoikis. HeLa cells are capable of anchorage-independent cell growth and acquire resistance to anoikis. We found that RNA interference-mediated knockdown of RhoG promoted anoikis in HeLa cells. Previous studies have shown that RhoG activates Rac1 and induces several cellular functions including promotion of cell migration through its effector ELMO and the ELMO-binding protein Dock180 that function as a Rac-specific guanine nucleotide exchange factor. However, RhoG-induced suppression of anoikis was independent of the ELMO- and Dock180-mediated activation of Rac1. On the other hand, the regulation of anoikis by RhoG required phosphatidylinositol 3-kinase (PI3K) activity, and constitutively active RhoG bound to the PI3K regulatory subunit p85α and induced the PI3K-dependent phosphorylation of Akt. Taken together, these results suggest that RhoG protects cells from apoptosis caused by the loss of anchorage through a PI3K-dependent mechanism, independent of its activation of Rac1