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Sample records for aguda vaciamiento radical

  1. Vaciamiento gástrico y diabetes mellitus tipo 2

    Camilo Andrés Quintero-Cadavid; William Otero-Regino; Roberto Franco-Vega

    2015-01-01

    El adecuado control de la diabetes mellitus tiene una gran importancia desde muchos puntos de vista. En los últimos años, se ha destacado el impacto que tienen los niveles de la glucemia postprandial sobre el manejo y las complicaciones de esta enfermedad. Controlar la hiperglucemia postprandial y, por lo tanto, su participación en el deterioro clínico de los pacientes con diabetes puede conseguirse retardando el vaciamiento gástrico y estimulando el efecto incretina, los cuales se pueden pro...

  2. Estandarización de valores de vaciamiento gástrico en sujetos normales por estudio gammagráfico en Cali.

    Adriana Rengifo; Eduardo Lima; Gustavo Mariño; Alfredo Rengifo; José Humberto Arango; Alberto Alzate; Fernando Tuffi García; Martha Susana Forero; Matilde De Bernal; Gloria Gamboa

    2009-01-01

    Se presenta una serie de 30 personas normales donde se evaluaron los tiempos de vaciamiento gástrico, por estudio gammagráfico. El objetivo del estudio fue conocer el rango de normalidad, para el tiempo de vaciamiento gástrico en sujetos asintomáticos entre 18 y 55 años. Hasta el presente estudio los valores de normalidad considerados se basaban en criterios de poblaciones en otros países, con características antropométricas y étnicas distintas. Se administró una mezcla semisólida de alimento...

  3. Apendicitis Aguda

    Jorge Fallas González

    2012-03-01

    Full Text Available La apendicitis aguda, descrita desde 1886, es la emergencia quirúrgica más común. Tiene su mayor incidencia durante la adultez joven y su menor incidencia en niños y adultos mayores. Su diagnóstico se basa en una historia clínica completa, un examen físico bien orientado y en una adecuada interpretación de los exámenes de laboratorio y gabinete. A pesar de ser una entidad de resolución quirúrgica, su tratamiento engloba diferentes aspectos médicosAcute appendicitis, described since 1886, is the most common surgical emergency. It has its highest incidence during early adulthood, and its lowest incidence in infants and elders. The base of the diagnosis is a complete medical history, an oriented physical exam and an appropriate interpretation of the laboratory and complementary exams. Even though its resolution is a surgical procedure, its treatment involves different medical aspects

  4. Radicals

    Jahn, Ullrich; Cornils, B.

    Weinheim: Wiley-VCH, 2013 - (Cornils, B.; Herrmann, W.; Wong, C.; Zanthoff, H.), s. 1897-1898 ISBN 978-3-527-33307-3 Institutional support: RVO:61388963 Keywords : radicals * enzymatic catalysis * coenzyme B12 * ribonucleotide reductase * mutases Subject RIV: CC - Organic Chemistry

  5. Insuficiencia renal aguda.

    Carlos Hernán Mejía

    2009-01-01

    La insuficiencia renal aguda se diagnostica aproximadamente en 5% de los pacientes hospitalizados. Sus principales causas se relacionan con la alteración del flujo sanguíneo renal, sea por depleción de volumen, baja perfusión renal o por distribución intrarrenal inadecuada y obstrucción del árbol urinario. El diagnóstico parte de la historia clínica y un buen examen físico que corrobore el estado de volemia del paciente y se complementa con el uso adecuado de los índices urinarios (excreción ...

  6. Insuficiencia renal aguda

    Carlos Hernán Mejía

    1985-01-01

    La insuficiencia renal aguda se diagnostica aproximadamente en 5% de los pacientes hospitalizados. Sus principales causas se relacionan con la alteración del flujo sanguíneo renal, sea por depleción de volumen, baja perfusión renal o por distribución intrarrenal inadecuada y obstrucción del árbol urinario. El diagnóstico parte de la historia clínica y un buen examen físico que corrobore el estado de volemia del paciente y se complementa con el uso adecuado de los índices urinarios (excreción ...

  7. Insuficiencia renal aguda.

    Carlos Hernán Mejía

    2009-10-01

    Full Text Available La insuficiencia renal aguda se diagnostica aproximadamente en 5% de los pacientes hospitalizados. Sus principales causas se relacionan con la alteración del flujo sanguíneo renal, sea por depleción de volumen, baja perfusión renal o por distribución intrarrenal inadecuada y obstrucción del árbol urinario. El diagnóstico parte de la historia clínica y un buen examen físico que corrobore el estado de volemia del paciente y se complementa con el uso adecuado de los índices urinarios (excreción de sodio y osmolaridad, el uroanálisis y la ecografía renal. Su tratamiento consiste en una adecuada recuperación del volumen, manejo de los diuréticos, soporte nutricional, conservación del equilibrio hidroelectrolítico y brindar terapia de diálisis si hay toxicidad urémica, hipercaliemia severa (>6.5 mEq/l, acidosis metabólica o sobrecarga severa de volumen.

  8. Ataxias agudas en la infancia

    Yaline Betancourt Fursow

    2013-09-01

    Full Text Available La ataxia cerebelosa aguda infantil (ACAI es la forma más frecuente de complicación neurológica por el virus de la varicela.Descritas dentro del grupo de las cerebelitis agudas. Los objetivos de este estudio fueron: evaluar la presentación clínica, manejo y seguimiento de niños hospitalizados con ACAI en un hospital pediátrico terciario donde la inmunización para varicela no está disponible (parte I y describir los diagnósticos diferenciales de la cerebelitis aguda (parte II. Estudiamos 95 pacientes. Los criterios diagnósticos de ataxia aguda se basaron en: pérdida aguda de la coordinación o dificultad para la marcha con o sin nistagmo asociado y duración menor de 48 horas, en un niño previamente sano. Estos criterios se cumplían en todos los casos valorados, excepto en las ataxias secundarias a ingesta de tóxicos, en los que la duración debía ser menor de 24 horas para su inclusión en el estudio. Se registraron los datos en una historia clínica pediátrica y neurológica. Entre los pacientes inmunosuprimidos la incidencia mayor fue la complicación por varicela. La mayoría de los pacientes fueron varones. El rango de edad fue la preescolar, 5 años . El intervalo entre la presentación del rash y el ingreso fue de 1 a 3 días. El estudio de LCR se practicó en 59.5% de los casos. La TAC y la resonancia magnética cerebral (RM presentaron edema en el 33.3%. El aciclovir endovenoso fue utilizado en 23 pacientes; pero no hubo diferencias significativas en las manifestaciones clínicas y seguimiento entre tratados y no tratados. La ataxia fue la primera manifestación clínica. La estadía hospitalaria fue de 4 días (rango: 2-11 días.

  9. Esofagitis necrotizante aguda en paciente inestable

    Rodrigo, M.; B.E. Gorraiz; Merino, C.; J. Eguaras; J.M. Elizalde; W. Soler

    2009-01-01

    La esofagitis necrotizante aguda o esófago negro es una afección rara, conocida en la literatura médica desde 1990. Aunque su mecanismo no es del todo conocido, el compromiso isquémico parece ser el factor fisiopatológico fundamental. Cuando la esofagitis necrotizante aguda es un hallazgo en el estudio endoscópico de hemorragia digestiva alta, sin desestabilización hemodinámica, el pronóstico es bueno. Presentamos un caso en el que el diagnóstico de esófago negro fue un mero hallazgo endoscóp...

  10. Leucemia congénita aguda

    Nilvia Esther González García; Regla Broche Cardó; Lissette Trelles Porro; María de los Ángeles Cubero Rego; Eduardo Morales Mesa; Alberto Arencibia Núñez; Luis Enrique Pérez Ulloa

    2011-01-01

    La leucemia aguda durante el período neonatal es poco frecuente de evolución rápida y pronóstico sombrío. Sus características clínicas y biológicas difieren de las encontradas en niños de mayor edad, y su inicio se caracteriza por afectación cutánea, hepatoesplenomegalia, hiperleucocitosis e infiltración del sistema nervioso central. Se han observado pacientes con formas tanto mieloides como linfoides, pero la leucemia mieloide aguda parece predominar en esta etapa de la vida. Se presenta el ...

  11. Esofagitis necrotizante aguda en paciente inestable

    M. Rodrigo

    2009-04-01

    Full Text Available La esofagitis necrotizante aguda o esófago negro es una afección rara, conocida en la literatura médica desde 1990. Aunque su mecanismo no es del todo conocido, el compromiso isquémico parece ser el factor fisiopatológico fundamental. Cuando la esofagitis necrotizante aguda es un hallazgo en el estudio endoscópico de hemorragia digestiva alta, sin desestabilización hemodinámica, el pronóstico es bueno. Presentamos un caso en el que el diagnóstico de esófago negro fue un mero hallazgo endoscópico, secundario a una situación de inestabilidad hemodinámica subyacente, con resultado fatal.

  12. Esofagitis necrotizante aguda: Una entidad inusual

    Silvana E. Pramparo; Pablo M. Ruiz; Rogelio Flores Valencia; José Rodeyro (h)

    2010-01-01

    La esofagitis necrotizante aguda (ENA), también denominada esófago negro, es una rara enfermedad poco descripta en la literatura médica. Describimos el caso de un hombre de 80 años, con hemorragia digestiva alta quien desarrolló un esófago negro luego de un episodio de hipotensión. La necrosis fue confirmada histológicamente. Los pacientes se presentan con hematemesis y melena en más del 70% de los casos. Los hallazgos endoscópicos muestran una coloración negruzca de la mucosa esofágica. El d...

  13. Biomarcadores da injúria renal aguda

    Luis Alberto Batista Peres; Ademar Dantas da Cunha Júnior; Alex Júnior Schäfer; Aline Liene da Silva; Arianne Ditzel Gaspar; Deborah Francisca Scarpari; Julia Barazetti Ferrari Alves; Rodolfo Girelli Neto; Thaís Figueiredo Teodoro de Oliveira

    2013-01-01

    A creatinina continua a ser o padrão laboratorial para diagnóstico da injúria renal aguda (IRA). Esforços para prevenção da nefrotoxicidade foram prejudicados pelo atraso no diagnóstico da IRA por critérios utilizando somente a creatinina como marcador, havendo, por isso, grande interesse em identificar mais precocemente biomarcadores confiáveis. Além disso, o tratamento precoce da IRA pode ser correlacionado com um melhor prognóstico e a identificação de biomarcadores para um diagnóstico pre...

  14. INSUFICIENCIA RENAL AGUDA CON UREMIA NORMAL EN PACIENTE MONO-RENO SECUNDARIA A PIELONEFRITIS AGUDA

    Musso CG

    2006-03-01

    Full Text Available RESUMEN:La insuficiencia renal aguda es un sindrome que característicamente cursa con niveles plasmáticos elevados de urea y creatinina. Sin embargo, hay situaciones clínicas en las cuales este sindrome puede cursar con un incremento de la creatininemia sin presentar elevación de la uremia.En este reporte presentamos un caso clínico de una insuficiencia renal aguda con uremia normal secundaria a una pielonefritis aguda en un paciente con riñón único. El paciente presentaba una elevada excreción fraccional de urea lo cual podía explicar su uremia normal pese a estar cursando una caída del filtrado gomerular. Dicha excreción de urea elevada fue interpretada como secundaria a una diabetes insipida nefrogénica y una alteración en el recirculado intra-renal de la urea ambos producto de la pielonefritis aguda. Concluimos que la pielonefritis aguda en un paciente mono-reno puede presentarse con un patrón de insuficiencia renal aguda con uremia normal. SUMMARYAcute renal failure is a syndrome that usually runs with an increase in creatinine and urea plasma levels. However, there are clinical situations in which this syndrome may run with an increase in plasma creatinine keeping normal the urea one.In this report we present a case of acute renal failure with normal plasma urea level secondary to an acute pyelonephritis in a single kidney patient. The patient had an increased fractional excretion of urea which could explain the normal plasma urea levels found despite of his reduced glomerular filtration. This increased urea excretion state was interpreted as a consequence of the nephrogenic diabetes insipidus and alteration of the intra-renal urea reciclying process that the acute pyelonephritis induced. In conclusion: Acute pyelonephritis in a single kidney patient can appear as a pattern of acute renal failure with normal plasma urea levels.

  15. INSUFICIENCIA RENAL AGUDA CON UREMIA NORMAL EN PACIENTE MONO-RENO SECUNDARIA A PIELONEFRITIS AGUDA

    Musso CG

    2007-04-01

    Full Text Available RESUMENLa insuficiencia renal aguda es un sindrome que característicamente cursa con niveles plasmáticos elevados de urea y creatinina. Sin embargo, hay situaciones clínicas en las cuales este sindrome puede cursar con un incremento de la creatininemia sin presentar elevación de la uremia. En este reporte presentamos un caso clínico de una insuficiencia renal aguda con uremia normal secundaria a una pielonefritis aguda en un paciente con riñón único. El paciente presentaba una elevada excreción fraccional de urea lo cual podía explicar su uremia normal pese a estar cursando una caída del filtrado gomerular. Dicha excreción de urea elevada fue interpretada como secundaria a una diabetes insipida nefrogénica y una alteración en el recirculado intra-renal de la urea ambos producto de la pielonefritis aguda. Concluimos que la pielonefritis aguda en un paciente mono-reno puede presentarse con un patrón de insuficiencia renal aguda con uremia normal.SUMMARYAcute renal failure is a syndrome that usually runs with an increase in creatinine and urea plasma levels. However, there are clinical situations in which this syndrome may run with an increase in plasma creatinine keeping normal the urea one. In this report we present a case of acute renal failure with normal plasma urea level secondary to an acute pyelonephritis in a single kidney patient. The patient had an increased fractional excretion of urea which could explain the normal plasma urea levels found despite of his reduced glomerular filtration. This increased urea excretion state was interpreted as a consequence of the nephrogenic diabetes insipidus and alteration of the intra-renal urea reciclying process that the acute pyelonephritis induced. In conclusion: Acute pyelonephritis in a single kidney patient can appear as a pattern of acute renal failure with normal plasma urea levels.

  16. Apendicite aguda: modelo experimental em coelhos

    EBRAM-NETO João

    2000-01-01

    Full Text Available Com objetivo de estudar experimentalmente as diversas fases evolutivas da apendicite aguda, foram utilizados 60 coelhos (Oryctogalus cuniculus, fêmeas, da linhagem Nova Zelândia, com peso variando de 2510 a 3040 gramas. Os animais foram divididos em dois grupos denominados controle e experimento, e estes subdivididos em três subgrupos com períodos de observação de 12, 24 e 48 horas. No grupo experimento foi realizada a oclusão do lume apendicular por meio de sutura seromuscular circular a 8 cm da extremidade distal do apêndice cecal, com fio de polipropileno 4-0. No controle foi feita somente a simulação da cirurgia. Os aspectos macroscópicos (aumento do tamanho, necrose, perfuração, aderência e secreção na cavidade abdominal bem como os microscópicos do grupo experimento, evidenciaram uma progressão das alterações anatomopatológicas mostrando haver uma relação entre a intensidade dos achados histopatológicos e o tempo de observação. Conclui-se que o método utilizado causa apendicite aguda com alterações anatomopatológicas distintas, de acordo com a fase evolutiva da doença.

  17. Intoxicación aguda por plaguicidas

    Durán-Nah Jaime Jesús

    2000-01-01

    Full Text Available OBJETIVO: Describir la epidemiología de la intoxicación aguda por plaguicidas (IAP en el Hospital General O'Horán de Mérida, Yucatán, México. MATERIAL Y MÉTODOS: Se revisaron los expedientes de 33 pacientes superscript three 13 años, tratados en una unidad de cuidados intensivos (UCI, entre 1994 y 1998. Se recopilaron variables demográficas y clínicas relevantes, y se aplicó estadística descriptiva. RESULTADOS: En la población estudiada predominó el sexo masculino (82% del medio rural (70%, y la edad media fue de 34 ± 15.8 años. El intento de suicidio fue causa frecuente de IAP (79%, y en 33% de los casos la intoxicación se produjo por la utilización de organofosforados. La mortalidad fue de 12%. CONCLUSIONES: La IAP fue baja entre los sujetos del medio rural, por lo que los resultados de este estudio parecen no reflejar la realidad del problema. Es importante añadir que los plaguicidas son utilizados con relativa frecuencia para el intento de suicidio.

  18. Esofagitis necrotizante aguda: Una entidad inusual

    Silvana E. Pramparo

    2010-12-01

    Full Text Available La esofagitis necrotizante aguda (ENA, también denominada esófago negro, es una rara enfermedad poco descripta en la literatura médica. Describimos el caso de un hombre de 80 años, con hemorragia digestiva alta quien desarrolló un esófago negro luego de un episodio de hipotensión. La necrosis fue confirmada histológicamente. Los pacientes se presentan con hematemesis y melena en más del 70% de los casos. Los hallazgos endoscópicos muestran una coloración negruzca de la mucosa esofágica. El diagnóstico se realiza con endoscopia y confirmación histológica. La mortalidad es alta (más del 50% aunque relacionada a las enfermedades de base del paciente. Por último, podemos decir que la sospecha es muy importante en el diagnóstico de ENA, particularmente en pacientes ancianos con enfermedades asociadas y evidencia de hemorragia digestiva alta. En este trabajo describimos las características clínicas, endoscópicas e histopatológicas de un paciente con ENA.

  19. Terapia cognitivo-conductual en las psicosis agudas

    María Isabel Gutiérrez López; María Sánchez Muñoz; Alejandra Trujillo Borrego; Luis Sánchez Bonome

    2012-01-01

    El tratamiento de las psicosis agudas era, hasta hace unos años, algo relegado al tratamiento farmacológico (a excepción del psicoanálisis). En los últimos tiempos esa tendencia ha ido cambiando y diversos estudios han puesto de manifiesto la ventaja de las intervenciones cognitivo conductuales en las fases agudas de las psicosis. A esta tendencia se ha unido un nuevo y prometedor paradigma de intervención temprana en psicosis. En el presente estudio se muestra una revisión bibliográfica de l...

  20. Leucemia congénita aguda Acute congenital leukemia

    Nilvia Esther González García; Regla Broche Cardó; Lissette Trelles Porro; María de los Ángeles Cubero Rego; Eduardo Morales Mesa; Alberto Arencibia Núñez; Luis Enrique Pérez Ulloa

    2011-01-01

    La leucemia aguda durante el período neonatal es poco frecuente de evolución rápida y pronóstico sombrío. Sus características clínicas y biológicas difieren de las encontradas en niños de mayor edad, y su inicio se caracteriza por afectación cutánea, hepatoesplenomegalia, hiperleucocitosis e infiltración del sistema nervioso central. Se han observado pacientes con formas tanto mieloides como linfoides, pero la leucemia mieloide aguda parece predominar en esta etapa de la vida. Se presenta el ...

  1. Radical Evil

    Carlos Manrique

    2007-12-01

    Full Text Available There is an aporia in Kant’s analysis of evil: he defines radical evilas an invisible disposition of the will, but he also demands an inferential connection between visible evil actions and this invisible disposition. This inference,however, undermines the radical invisibility of radical evil according to Kant’s own definition of the latter. Noting how this invisibility of moral worth is a distinctive feature of Kant’s approach to the moral problem, the paper then asks why, in the Groundwork, he nonetheless forecloses a question about evil that seems to be consistent with this approach. It is argued that to account for this aporia and this foreclosure, one has to interrogate the way in which the category of religion orients Kant’s incipient philosophy of history in Die Religion.

  2. Radical Geography

    H. Hataminezhad

    2012-07-01

    Full Text Available Interdisciplinary sciences emerging and specialization were result of historical conditions. Lack of common and grand theories have caused social sciences such as Geography disintegrated to many courses. The Geography science has been divided two main courses, Physical and Human through the time. Every one used another similar science in theoretical principles and methodologies for their domain development and strengthening of their bases. The Human Geography was influenced by Anthropology during nineteenth century and was affected by nineteenth century and dawn twentieth century by Sociology and from mid twentieth century until present time by Biological sciences, Psychology, Political economics and social theories. Radical Geography was one of the Human Geography branches that was influenced by Political economics and left ideology. Radical Geography emphasizes on investigation about quality of life in different spaces and attempts to change socio-economic and spatial relationships, therefore critical Geography is one of its similar approaches.

  3. Leucemia promielocítica aguda. Comportamiento clínico

    José Ignacio Larquin Comet; Angelina Leyva Diviú; Cira León Ramentol; Yisel García Fontes

    2008-01-01

    Fundamento: La leucemia promielocítica aguda es una forma peculiar de leucemia aguda no linfoblástica, con características clínicas y biológicas muy específicas, que la diferencian del resto de las leucemias agudas. Objetivo: Corroborar las características clínicas de la leucemia promielocítica aguda teniendo en cuenta sus variedades morfológicas, así como las manifestaciones clínicas y hematológicas. Método: Se realizó un estudio descriptivo transversal en el departamento de Hematología del ...

  4. Pancreatite aguda : estratificação de risco

    Condado, Daniana Alexandra Sirgado de Alpoim

    2012-01-01

    A pancreatite aguda é definida como uma condição inflamatória aguda do pâncreas, com acometimento variável das estruturas peripancreáticas e órgãos a distância, cuja génese depende da autodigestão do seu parênquima pelas próprias enzimas pancreáticas. Representa uma das principais causas de internamento em unidades de cuidados intensivos de gastroenterologia. A sua incidência varia nos diferentes países e depende da etiologia. A sua patogénese ainda não está completamente esclarecida, mas con...

  5. Toxicología aguda del D-004 en conejos

    Ariadne Gutiérrez Martínez

    2007-01-01

    entre los grupos tratados y el control en ninguno de los sexos. El D-004 presentó una toxicidad intrínseca baja, al mostrar una DL50 superior a los 2 000 mg/kg de peso corporal, dosis con la que no se evidenciaron signos indicativos de toxicidad en ninguno de los sexos, por lo que su toxicidad se puede declarar como no clasificable según el método de las clases de toxicidad aguda.

  6. Miopia aguda induzida por topiramato: relato de dois casos

    Kathy Dadam Sgrott; André Luis Momm da Silva; Luiz Felipe Hagemann; Vilmar Müller; Fernando César Ludwig

    2011-01-01

    RESUMO A miopia aguda pode ser desencadeada pelo uso de medicações sistêmicas, dentre elas, o anticonvulsivante topiramato. Este trabalho descreve dois casos de pacientes jovens com quadro agudo bilateral de miopia induzida por terapia com topiramato para controle de síndrome depressiva, fazendo relação com casos semelhantes descritos na literatura e revisão bibliográfica pertinente.

  7. Miopia aguda induzida por topiramato: relato de dois casos

    Kathy Dadam Sgrott

    2011-06-01

    Full Text Available RESUMO A miopia aguda pode ser desencadeada pelo uso de medicações sistêmicas, dentre elas, o anticonvulsivante topiramato. Este trabalho descreve dois casos de pacientes jovens com quadro agudo bilateral de miopia induzida por terapia com topiramato para controle de síndrome depressiva, fazendo relação com casos semelhantes descritos na literatura e revisão bibliográfica pertinente.

  8. Roaming Radicals

    Bowman, Joel M.; Shepler, Benjamin C.

    2011-05-01

    Roaming is a recently verified unusual pathway to molecular products from unimolecular dissociation of an energized molecule. Here we present the evidence for this pathway for H2CO and CH3CHO. Theoretical analysis shows that this path visits the plateau region of the potential energy surface near dissociation to radical products. It is not clear whether roaming is a distinct isolated pathway, in addition to the conventional one via the well-known molecular saddle-point transition state. Evidence is presented to suggest that the two pathways may originate from a single, but highly complicated, dividing surface. Other examples of unusual reaction dynamics are also reviewed.

  9. Insuficiencia renal aguda asociada a picadura de abeja africanizada

    Verny Huertas-Franco

    2008-03-01

    Full Text Available Se presenta el caso de un adulto mayor diabético tipo 2, que sufrió un ataque masivo de abejas africanizadas, y llegó a la sala de emergencias tres horas después del inicio del ataque. El paciente presentó insuficiencia renal aguda por combinación de factores, y se recuperó con tratamiento de diálisis temprana. Se discuten los problemas que refieren estos pacientes, y cuál sería el manejo ideal de tales casos.

  10. Recomendaciones para el manejo de la faringoamigdalitis aguda del adulto

    Cots, Josep M; Juan-Ignacio Alós; Mario Bárcena; Xavier Boleda; José L. Cañada; Niceto Gómez; Ana Mendoza; Isabel Vilaseca; Carles Llor

    2015-01-01

    La faringoamigdalitis aguda (FAA) en el adulto es una de las enfermedades infecciosas más comunes en la consulta del médico de familia. La etiología más frecuente es viral. Dentro de la etiología bacteriana, el principal agente responsable es Streptococcus pyogenes o estreptococo β-hemolítico del grupo A (EBHGA), causante del 5-30% de los casos. En el manejo diagnóstico, las escalas de valoración clínica para predecir la posible etiología bacteriana, son una buena ayuda para seleccionar a qué...

  11. Carambola como causa de lesão renal aguda

    Karilla Lany Scaranello; Valeria Regina de Cristo Alvares; Daniely Maria Queiroz Carneiro; Flávio Henrique Soares Barros; Thais Marques Sanches Gentil; Myriam José Thomaz; Benedito Jorge Pereira; Mariana Batista Pereira; Graziella Malzoni Leme; Mary Carla Esteves Diz; Sandra Maria Rodrigues Laranja

    2014-01-01

    A carambola pertence à família das Oxalidáceas, espécie Averrhoa carambola. É rica em sais minerais, vitaminas A, C, complexo B e ácido oxálico. Estudos recentes demonstram que a toxicidade da fruta difere entre os indivíduos e pode ser explicada pelas respostas biológicas individuais como idade, quantidade da ingestão, neurotoxinas em cada tipo de fruta. Adicionalmente, a nefrotoxicidade causada pela fruta é dose dependente, podendo levar ao desenvolvimento de lesão renal aguda pela deposiçã...

  12. Toxicología aguda del D-004 en conejos

    Ariadne Gutiérrez Martínez; Rafael Gámez Menéndez; Rosa Más Ferreiro; Miriam Noa Puig; Balia Pardo Acosta; Eddy Goicochea Carrero; Dayisell Curveco Sánchez; Haydée García Cambián

    2007-01-01

    El D-004 es un extracto lipídico obtenido del fruto de la palma real (Roystonea regia) (Arecaceae) que consiste en una mezcla reproducible de ácidos grasos, en la cual el ácido oleico, el láurico y el palmítico son los más abundantes. El tratamiento oral con D-004 inhibe significativamente la hiperplasia prostática inducida por testosterona en roedores. La toxicología preclínica de un nuevo compuesto incluye la evaluación aguda en una especie no roedora. Con este objetivo se realizó el ensayo...

  13. Bronquiolite aguda, uma revisão atualizada

    Werther Brunow de Carvalho; Cíntia Johnston; Marcelo Cunio Fonseca

    2007-01-01

    A bronquiolite aguda (BA) é um diagnóstico freqüente de internação hospitalar em pediatria, ocasionada principalmente pelo vírus sincicial respiratório (VSR). Ocorre epidemicamente nos meses de outono e inverno. Algumas populações de crianças (recém-nascidos pré-termo, cardiopatia congênita, doença pulmonar crônica, imunocomprometidos, desnutridos, entre outros) apresentam maior risco de morbidade e mortalidade. Os vírus multiplicam-se nas células epiteliais ciliadas, e a inflamação e os debr...

  14. Tratamento de leucemia linfóide aguda e crescimento

    Monteiro I.M.U.; Bedone A.J.; Pinto C.L.B.; Brandalise S.R.

    1998-01-01

    OBJETIVO: Determinar alterações no crescimento após o tratamento de leucemia linfóide aguda em meninas. PACIENTES E MÉTODO: Realizou-se estudo retrospectivo com 59 meninas que apresentavam medidas de estatura antes e com no mínimo um ano do tratamento, subdivididas de acordo com a dose de radioterapia cranial utilizada [18 ou 24 Grays (Gy)] e com a idade no início do tratamento (antes e após os cinco anos de idade). RESULTADOS: Observou-se deficiência do crescimento com um, dois e mais de doi...

  15. Diplopia aguda postlaberintectomía química

    Santos Gorjón, Pablo; Collado Lorduy, Teresa; Sánchez Terradillos, Elena; Sánchez-Jara Sánchez, Juan Luis; Velasco García, María Jesús; Martín Hernández, Gonzalo

    2012-01-01

    [ES]Introducción: La laberintectomía química con gentamicina es un procedimiento ambulatorio considerado seguro y eficaz y que provoca poca iatrogenia. Presentamos un caso clínico de una rara complicación de la técnica y se revisa la literatura. Caso clínico: Paciente diagnosticada de enfermedad de Ménière izquierda que no responde a esquema de tratamiento conservador. Se propone realizar terapia intratimpánica con corticoide y después una laberintectomía química. Aparece de forma aguda u...

  16. Pancreatite Aguda Necrosante — Caso Clínico

    Soares, E.; Alves, R.; M. España; Vale, MC; Barata, D; J. Magalhães; C. Vasconcelos

    1998-01-01

    Os autores apresentam um caso clínico de Pancreatite Aguda Hemorrágica, de provável etiologia idiopática, numa criança de 10 meses, que se manifestou inicialmente por vómitos, e alteração do estado de consciência e posteriormente por abdómen agudo. O diagnóstico foi feito durante a laparotomia. Houve boa evolução clínica. Como complicações, refere-se o aparecimento de dois pseudoquistos pancreáticos que regrediram progressiva e espontaneamente.

  17. Carambola como causa de lesão renal aguda

    Karilla Lany Scaranello

    2014-04-01

    Full Text Available A carambola pertence à família das Oxalidáceas, espécie Averrhoa carambola. É rica em sais minerais, vitaminas A, C, complexo B e ácido oxálico. Estudos recentes demonstram que a toxicidade da fruta difere entre os indivíduos e pode ser explicada pelas respostas biológicas individuais como idade, quantidade da ingestão, neurotoxinas em cada tipo de fruta. Adicionalmente, a nefrotoxicidade causada pela fruta é dose dependente, podendo levar ao desenvolvimento de lesão renal aguda pela deposição de cristais de oxalato de cálcio intratubular, assim como por lesão direta das células epiteliais tubulares, levando à apoptose das mesmas. Relatamos o caso de uma paciente que, após a ingestão do suco da fruta e fruta in natura, desenvolveu lesão renal aguda, necessitando de terapia dialítica, evoluindo com desfecho favorável e recuperação da função renal.

  18. Oclusión arterial aguda asociada a hidatidosis diseminada

    Jose Somocurcio

    2014-04-01

    Full Text Available Hidatidosis o equinococosis son términos usados para denominar a la infestación zoonótica causada por los estadios adulto y larvario (metacéstode del céstode del género Equinococcus (familia tenidae. El término hidatidosis debe ser aplicado a la infestación por el metacéstode mientras que el de equinococosis a los estadios larvario y adulto. En el Perú existe una alta prevalencia de esta infección siendo el hígado y pulmón los órganos más afectados. Existen factores tanto del agente infeccioso como del hospedero que contribuyen a esta infección, donde el componente inmunológico del hospedero es un punto importante tanto en la infección como en la diseminación. En el presente artículo se reporta un caso de oclusión arterial aguda asociada a hidatidosis diseminada en un paciente de 54 años de edad, natural y procedente de Huancavelica, de inicio súbito con un cuadro de obstrucción arterial aguda; que no mejoró luego de la cirugía con fallecimiento a las 48 horas de la presentación

  19. Oclusión arterial aguda asociada a hidatidosis diseminada

    Jose Somocurcio

    2014-06-01

    Full Text Available Hidatidosis o equinococosis son términos usados para denominar a la infestación zoonótica causada por los estadios adulto y larvario (metacéstode del céstode del género Equinococcus (familia tenidae. El término hidatidosis debe ser aplicado a la infestación por el metacéstode mientras que el de equinococosis a los estadios larvario y adulto. En el Perú existe una alta prevalencia de esta infección siendo el hígado y pulmón los órganos más afectados. Existen factores tanto del agente infeccioso como del hospedero que contribuyen a esta infección, donde el componente inmunológico del hospedero es un punto importante tanto en la infección como en la diseminación. En el presente artículo se reporta un caso de oclusión arterial aguda asociada a hidatidosis diseminada en un paciente de 54 años de edad, natural y procedente de Huancavelica, de inicio súbito con un cuadro de obstrucción arterial aguda; que no mejoró luego de la cirugía con fallecimiento a las 48 horas de la presentación

  20. Terapia cognitivo-conductual en las psicosis agudas

    María Isabel Gutiérrez López

    2012-01-01

    Full Text Available El tratamiento de las psicosis agudas era, hasta hace unos años, algo relegado al tratamiento farmacológico (a excepción del psicoanálisis. En los últimos tiempos esa tendencia ha ido cambiando y diversos estudios han puesto de manifiesto la ventaja de las intervenciones cognitivo conductuales en las fases agudas de las psicosis. A esta tendencia se ha unido un nuevo y prometedor paradigma de intervención temprana en psicosis. En el presente estudio se muestra una revisión bibliográfica de las investigaciones más relevantes publicadas hasta la fecha en torno a esta temática. Se incluyeron aquellos trabajos con un diseño controlado y aleatorio, que garantizaban requisitos de fiabilidad y validez. Los estudios muestran resultados esperanzadores, en cuanto que avalan la eficacia de la TCC como medida de tratamiento. Sin embargo, todavía se hace necesario un mayor número de investigaciones que avalen estos datos.

  1. Algunas observaciones sobre la apendicitis aguda en los niños

    Piñeros Suárez, Luis

    2011-01-01

    La apendicitis aguda en los niños, presenta actitudes particulares que diferencian de la apendicitis aguda del adulto y que vienen a formar grupos clínicos casi exclusivamente de la infancia. De una manera general, las formas más graves, las formas fulminantes de la apendicitis aguda se encuentran especialmente en la infancia y en estas formas graves llama poderosamente la atención, la falta de relación entre los signos clínicos observados y la importancia de las lesiones encontradas en el ap...

  2. Papel del estrés oxidativo y del tejido adiposo en la pancreatitis aguda experimental

    Pérez Garrido, Salvador

    2013-01-01

    La pancreatitis aguda es un proceso inflamatorio agudo del páncreas con afectación variable de otros tejidos y sistemas orgánicos alejados. La incidencia de la pancreatitis aguda en la Unión Europea y Estados Unidos varía de 5 a 30 casos/100.000/año (Ellis y cols., 2009). La mortalidad en pacientes con pancreatitis aguda es alrededor del 5%, pero este porcentaje aumenta al 17-20% en pacientes con pancreatitis necrotizante (Pandol y cols., 2007). La participación del estrés oxidativo en la ...

  3. Esofagitis necrosante aguda: análisis retrospectivo Acute esophageal necrosis: a retrospective case series

    R Ramos; Mascarenhas, J.; P. Duarte; C. Vicente; Casteleiro, C.

    2008-01-01

    Introducción: la esofagitis necrosante aguda es una entidad rara. Se reconoce por el aspecto negro difuso del esófago a la endoscopia. Su incidencia e patogénesis se desconoce. Pacientes y métodos: se analizaron retrospectivamente 11 pacientes con esofagitis necrosante aguda desde el punto de vista de los datos clínicos, de laboratorio y endoscopicos en 2 años. Resultados: se analizaron las endoscopias realizadas a 3.976 pacientes, observándose esofagitis necrosante aguda en 11 pacientes. El ...

  4. Comportamiento de la enfermedad diarreica aguda en Guatemala

    Mario Enrique Plá Acevedo

    2015-12-01

    Full Text Available Se realizó un estudio descriptivo de corte transversal, con el objetivo de conocer el comportamiento de la Enfermedad Diarreica Aguda (EDA en Tierra Blanca, Departamento Petén, Guatemala; en el período comprendido de enero a diciembre del año 2011. El universo de estudio lo formaron todos los individuos que fueron evaluados en el puesto de salud de Tierra Blanca con diagnóstico clínico de EDA. La muestra estuvo constituida por 529 pacientes. Se trabajó con el Sistema de Información Gerencial en Salud 18 (SIGSA, las fichas de salud individual de cada paciente, así como una entrevista estructurada que se le aplicó a los mismos, previo consentimiento informado; información con la cual se obtuvieron las variables relacionadas con los aspectos socio-demográficos, epidemiológicos y clínicos. Los meses donde más casos se reportaron fueron entre mayo y septiembre, coincidiendo esto con los meses de lluvias. Las edades más frecuentes fueron de uno a diez años y el sexo que predominó fue el masculino. El 40,3% consumían agua procedente de chorro intradomiciliario; las infecciones respiratorias agudas fueron las patologías que con más frecuencia se asociaron a las EDA y el 88,1% recibió tratamiento con sales de rehidratación oral.

  5. Radical prostatectomy - discharge

    ... prostatectomy - discharge; Laparoscopic radical prostatectomy - discharge; LRP - discharge; Robotic-assisted laparoscopic prostatectomy - discharge ; RALP - discharge; Pelvic lymphadenectomy - ...

  6. Free radical inactivation of trypsin

    Reactivities of free radical oxidants, radical OH, Br2-anion radical and Cl3COO radical and a reductant, CO2-anion radical, with trypsin and reactive protein components were determined by pulse radiolysis of aqueous solutions at pH 7, 200C. Highly reactive free radicals, radical OH, Br2-anion radical and CO2-anion radical, react with trypsin at diffusion controlled rates. Moderately reactive trichloroperoxy radical, k(Cl3COO radical + trypsin) preferentially oxidizes histidine residues. The efficiency of inactivation of trypsin by free radicals is inversely proportional to their reactivity. The yields of inactivation of trypsin by radical OH, Br2-anion radical and CO2-anion radical are low, G(inactivation) = 0.6-0.8, which corresponds to ∼ 10% of the initially produced radicals. In contrast, Cl3COO radical inactivates trypsin with ∼ 50% efficiency, i.e. G(inactivation) = 3.2. (author)

  7. Treatment of acute experimental schistosomiasis Tratamento da esquistossomose aguda experimental

    Zilton A. Andrade

    1989-12-01

    Full Text Available A model of acute schistosomiasis of the mouse was used to observe whether curative treatment would be followed by an enhancement of the hepatic and splenic lesions, as a consequence of the massive destruction of worms and eggs within the portal system. Mice infected with 50 cercariae of Schistosoma mansoni were treated with both oxamniquine and praziquantel on the 50th day of infection and submitted to a sequential histologic examination from the 2nd to the 45th day after treatment. Although severe focal lesions due to dead and disintegranting worms were present in the livers of the treated animals, no aggravation of the general changes (reative hepatitis and splenitis, or periovular granulomas was seen in comparison with a control non-treated group. Of 50 animals treated during the acute phase of schistosomiasis only one died espontaneously, while 16 ou of 30 infected controls died before the end of the experiment. The present investigation indicates that curative treatment during the acute phase of schistosomiasis does not enhance previous lesions at first and results in progressive disappearance of the lesions starting six days following chemotherapy.Foi utilizado um modelo de esquistossomose aguda do camundongo para testar se o tratamentop curativo da parasitose nesta fase poderia produzir uma exacerbação das lesões hepáticas e esplênicas, em virtude da destruição maciça de vermes e ovos nointerior do sistema porta. Camundongos infectados com 50 cercárias do Schistosoma mansoni foram tratados no 50º dia da infecção por uma combinação de oxamniquine e praziquantel e submetidos a exames histopatológicos seqüenciados desde o 2º até o 45º dia após o tratamento. Muito embora tenham sido encontrados lesões focais intensas causadas por vermes mortos no interior do fígado, não foi encontrada qualquer evidência de agravamento das lesões gerais (hepatite reacional e esplenite, ou nos granulomas periovulares quando se fez

  8. Recomendaciones para el manejo de la faringoamigdalitis aguda del adulto

    Josep M. Cots

    2015-10-01

    Full Text Available La faringoamigdalitis aguda (FAA en el adulto es una de las enfermedades infecciosas más comunes en la consulta del médico de familia. La etiología más frecuente es viral. Dentro de la etiología bacteriana, el principal agente responsable es Streptococcus pyogenes o estreptococo β-hemolítico del grupo A (EBHGA, causante del 5-30% de los casos. En el manejo diagnóstico, las escalas de valoración clínica para predecir la posible etiología bacteriana, son una buena ayuda para seleccionar a qué pacientes se deben practicar las técnicas de detección rápida de antígeno estreptocócico. Es conocido que, en general, sin estas técnicas se tiende al sobrediagnóstico de FAA estreptocócica, con la consiguiente prescripción innecesaria de antibióticos, muchas veces de amplio espectro. Así, con el manejo de las escalas y la técnica de diagnóstico rápido, elaboramos los algoritmos de manejo de la FAA. Los objetivos del tratamiento son acelerar la resolución de los síntomas, reducir el tiempo de contagio y prevenir las complicaciones supurativas locales y no supurativas. Los antibióticos de elección para el tratamiento de la FAA estreptocócica son penicilina y amoxicilina. La asociación de amoxicilina y clavulánico no está indicada en el tratamiento inicial en la infección aguda. Los macrólidos tampoco son un tratamiento de primera elección; su uso debe reservarse para pacientes con alergia a la penicilina. Es importante en nuestro país adecuar tanto el diagnóstico de la FAA bacteriana y la prescripción de antibióticos a la evidencia científica disponible. La implantación de protocolos de actuación en las farmacias comunitarias puede ser de utilidad para identificar y cribar los casos que no requieran tratamiento antibiótico.

  9. Radical theory of rings

    Gardner, JW

    2003-01-01

    Radical Theory of Rings distills the most noteworthy present-day theoretical topics, gives a unified account of the classical structure theorems for rings, and deepens understanding of key aspects of ring theory via ring and radical constructions. Assimilating radical theory's evolution in the decades since the last major work on rings and radicals was published, the authors deal with some distinctive features of the radical theory of nonassociative rings, associative rings with involution, and near-rings. Written in clear algebraic terms by globally acknowledged authorities, the presentation

  10. Detección molecular de las translocaciones más comunes en leucemia aguda mediante rt-pcr

    Guevara G.; García L.

    2011-01-01

    Evaluar la incidencia de las translocaciones t(4;11), t(1;19), t(9;22) y t(12;21) en leucemia linfoide aguda (LLA) y t(15;17), t(8;21) e Inv.(16) en leucemia mieloide aguda (LMA). Correlacionar los resultados obtenidos con el diagnóstico morfológico y citogenético.

  11. Pericarditis aguda: diagnóstico electrocardiográfico

    Abraham enrique Katime Zúñiga

    2014-06-01

    Full Text Available La pericarditis es un proceso inflamatorio del pericardio, por lo general relacionado con procesos virales respiratorios o gastrointestinales; esta entidad es una de las principales causas de dolor torácico en el servicio de urgencias. El médico debe estar familiarizado con las manifestaciones clínicas y el flujograma diagnóstico. El diagnóstico de la pericarditis usualmente es clínico, los estudios paraclínicos evidencian inflamación sistémica (leucocitosis, aumento de la VSG y PCR. Las enzimas cardíacas (CPK MB – Troponinas se encuentran elevadas en casos de compromiso miocárdico asociado (Miopericarditis. El ecocardiograma revela derrame pericárdico, y el electrocardiograma se caracteriza por elevación difusa del segmento ST. En este artículo revisaremos los principales cambios electrocardiográficos relacionados a la pericarditis aguda y sus complicaciones. (Duazary 2009-II 159-164

  12. Formas agudas de periodontitis Acute conditions of periodontal disease

    L. Pérez-Salcedo

    2008-04-01

    Full Text Available La clasificación de las Enfermedades Periodontales ha cambiado en las últimas décadas. En la clasificación la AAP de 1989 la periodontitis necrotizante ocupaba el cuarto lugar. En el Workshop Europeo de 1993 la periodontitis necrotizante aparece en el grupo de los descriptores primarios. Según el Internacional Workshop for a Classification of Periodontal Diseases and Conditions 1999 en el que se revisó y se modificó la clasificación de las patologías periodontales, las enfermedades periodontales necrotizantes ocupan el punto cinco, diferenciándose entre Gingivitis Necrotizante y Periodontitis Necrotizante. Y se añade en la clasificación el grupo de abscesos periodontales. En este artículo de revisión vamos a profundizar acerca de las formas agudas de periodontitis.The Periodontal Diseases classification had changed in the last decades. In AAP classification of 1989 the necrotize was in the 4th position. In the European Workshop was in the group of primary descriptors. According to the International Workshop for a Classification of Periodontal Diseases and Conditions 1999, review and modificated the classification of periodontal pathologies, the periodontal necrotize diseases are in the 5th position, distinguishing between Necrotize Gingivitis and Necrotize Periodontitis. And Peridontal Abscesses was add to the classification. In this paper we are going to review about the acute forms of Periodontal Diseases.

  13. Laparoscopic radical cystectomy

    Fergany, Amr

    2012-01-01

    Objective Laparoscopic radical cystectomy (LRC) has emerged as a minimally invasive alternative to open radical cystectomy (ORC). This review focuses on patient selection criteria, technical aspects and postoperative outcomes of LRC. Methods Material for the review was obtained by a PubMed search over the last 10 years, using the keywords ‘laparoscopic radical cystectomy’ and ‘laparoscopic bladder cancer’ in human subjects. Results Twenty-two publications selected for relevance and content we...

  14. Laparoscopic Radical Trachelectomy

    Rendón, Gabriel J.; Ramirez, Pedro T.; Frumovitz, Michael; Schmeler, Kathleen M.; Pareja, Rene

    2012-01-01

    Introduction: The standard treatment for patients with early-stage cervical cancer has been radical hysterectomy. However, for women interested in future fertility, radical trachelectomy is now considered a safe and feasible option. The use of minimally invasive surgical techniques to perform this procedure has recently been reported. Case Description: We report the first case of a laparoscopic radical trachelectomy performed in a developing country. The patient is a nulligravid, 30-y-old fem...

  15. Síndrome coronariana aguda em paciente jovem com sintomas atípicos

    Gustavo Daher; Henrique Lane Staniak; Márcio Sommer Bittencourt; Rodolfo Sharovsky

    2012-01-01

    O diagnóstico da dor torácica aguda no setor de emergência pode ser difícil e desafiador, incluindo diversos diagnósticos diferenciais, dentre eles: causas benignas a causas potencialmente fatais. O diagnóstico na maioria das vezesé estabelecido através do quadro clínico e de exames complementares como: marcadores de necrose miocárdica, eletrocardiograma e radiografia de tórax.A angiotomografia coronariana tem sido utilizada nos casos de dor torácica aguda com baixa ou intermediária probabili...

  16. Toxicidad aguda y crónica del lindano sobre Ceriodaphnia cornuta (Cladocera: Daphniidae)

    Jorgelina Juárez; Alcira Villagra de Gamundi

    2011-01-01

    El lindano es un plaguicida organoclorado cuya toxicidad produce efectos nocivos en la salud humana y la biota. El objetivo de este estudio fue evaluar la toxicidad aguda y crónica del lindano sobre el microcrustáceo Ceriodaphnia cornuta. Para las pruebas agudas se empleó un diseño estático, usando 10 neonatos ≤ 24 horas de edad para el control y para cada concentración de lindano (5, 10, 15, 20 y 25 mg/L). Se realizaron tres réplicas de cada tratamiento. Se controló la inmovilización de los ...

  17. Esofagitis necrotizante aguda en paciente inestable Acute necrotizing esophagitis in an unstable patient

    Rodrigo, M.; B.E. Gorraiz; Merino, C.; J. Eguaras; J.M. Elizalde; W. Soler

    2009-01-01

    La esofagitis necrotizante aguda o esófago negro es una afección rara, conocida en la literatura médica desde 1990. Aunque su mecanismo no es del todo conocido, el compromiso isquémico parece ser el factor fisiopatológico fundamental. Cuando la esofagitis necrotizante aguda es un hallazgo en el estudio endoscópico de hemorragia digestiva alta, sin desestabilización hemodinámica, el pronóstico es bueno. Presentamos un caso en el que el diagnóstico de esófago negro fue un mero hallazgo endoscóp...

  18. Nuevas perspectivas en el tratamiento de la diarrea aguda del lactante: racecadotrilo

    Maldonado Lozano, Jos??

    2006-01-01

    El prop??sito del presente trabajo es realizar una puesta al d??a del tratamiento de la diarrea aguda del lactante, as?? como evaluar la efi cacia del racecadotrilo, un nuevo f??rmaco antisecretor intestinal, en el tratamiento de la diarrea aguda. Se revisan los datos disponibles en la bibliograf??a referentes al tratamiento de rehidrataci??n y realimentaci??n y sobre racecadotrilo, en este ??ltimo caso tanto en experimentaci??n animal como sobre el tratamiento de adultos y ni??os...

  19. Intoxicaciones agudas en pacientes mayores de 65 años

    P. Miranda Arto; A. Ferrer Dufol; F.J. Ruiz Ruiz; S. Menao Guillén; E. Civeira Murillo

    2014-01-01

    Fundamento. Los estudios sobre la intoxicación aguda en sujetos de edad avanzada en nuestro país son escasos, a pesar de los riesgos asociados que presenta este grupo de pacientes. Material y métodos. Estudio descriptivo retrospectivo de las intoxicaciones agudas atendidas en el servicio de Urgencias del Hospital Clínico Universitario de Zaragoza entre 1995 y 2009, en pacientes con edad igual o mayor a 65 años. Resultados. Se registraron 762 casos, el 4,74% del total de intoxicados, con una e...

  20. Lúpus eritematoso sistêmico e pancreatite aguda: relato de dois casos

    Ana Beatriz Cordeiro de Azevedo; Fabiano Almeida Brito; Flávia Patrícia Sena Teixeira Santos; Gilda Aparecida Ferreira; Marco Antônio Parreiras de Carvalho

    2003-01-01

    A pancreatite aguda é uma manifestação incomum do lúpus eritematoso sistêmico (LES) e a freqüência desta associação não é conhecida. Contudo, a pancreatite aguda é um diagnóstico diferencial importante na avaliação da dor abdominal em pacientes com LES. Os pacientes, normalmente, apresentam dor de intensidade variável, algumas vezes simulando abdome agudo. Vários fatores têm sido implicados na patogênese desta condição, tais como fenômenos autoimunes, vasculite, anticorpos antifosfolípides e ...

  1. Efectividad de la magnetoterapia como tratamiento en pacientes con lumbalgia aguda

    Raidel González Rodríguez; Juan Cardentey García

    2015-01-01

    Son numerosos los pacientes aquejados de algias vertebrales, tanto lumbares como dorsales y cervicales. Se realizó esta investigación con el objetivo de determinar la efectividad de la magnetoterapia como tratamiento en la lumbalgia aguda, en pacientes atendidos en el policlínico universitario “Raúl Sánchez” de la provincia de Pinar del Río, Cuba. Se realizó un estudio descriptivo, prospectivo, de corte transversal en pacientes con lumbalgia aguda, pertenecientes a dicha área de salud. La mue...

  2. Plasmaférese como modalidade terapêutica na pancreatite aguda por hipertrigliceridemia

    Felipe Soares Castelliano Lucena de Castro; Ana Maria Reis Nascimento; Igor Amorim Coutinho; Fernanda Ribeiro de Fernandez Y Alcazar; Jorge Mugayar Filho

    2012-01-01

    Pancreatite aguda é uma condição inflamatória manifestada clinicamente por dor abdominal e níveis séricos elevados das enzimas pancreáticas. A hipertrigliceridemia é sua terceira causa mais comum. O presente relato teve por objetivo descrever um caso de pancreatite aguda por hipertrigliceridemia, cuja modalidade terapêutica utilizada foi a plasmaférese. Paciente, gênero feminino, 48 anos, apresentou-se ao hospital com queixa de "dor muito forte na barriga". Relatou início do quadro com náusea...

  3. Intoxicación aguda por hidrato de hidracina

    Santiago Nogué Xarau

    2008-06-01

    Full Text Available Se aporta un caso de exposición aguda, debido a un vertido accidental de unos 25 litros de hidrato de hidracina, que el trabajador estuvo recogiendo sin ningún tipo de equipo de protección individual. El trabajador presentó alteraciones bucales, cutáneas y dolores abdominales difusos. De las pruebas complementarias únicamente se detectó un aumento de la bilirrubina total con predominio de la indirecta. Se le separó de la exposición, se le administró un tratamiento sintomático y en un periodo de un mes se recuperó íntegramente. Se comenta los principales casos de intoxicación por hidracina descritos en la literatura médica y se enfatiza en las medidas preventivas que se deben tomar para evitar casos como éste.We report a case of poisoning by acute exposure to hydrazine hydrate in a worker clearing up an accidental spillage of about 25 litres of the product who had no type of individual protective equipment. The patient presented buccal and cutaneous involvement and diffuse abdominal pain. Complementary tests were unremarkable except for an increase in total bilirubin with a predominance of indirect bilirubin. The patient was removed from the occupational exposure, symptomatic treatment was administered and the patient recovered completely after one month. We review the main reported cases of hydrazine poisoning and emphasize the preventive measures that should be taken to avoid this type of poisoning.

  4. Injúria renal aguda: um alerta global

    Philip Kam Tao Li

    2013-03-01

    Full Text Available A Injúria Renal Aguda (IRA é cada vez mais prevalente nos países desenvolvidos e nos em desenvolvimento, e está associada com morbidade e mortalidade severas. A maioria das causas da IRA pode ser evitada por meio de intervenções em nível individual, comunitário, regional e intra-hospitalar. Medidas efetivas devem incluir, em toda a comunidade, os esforços para aumentar a consciência dos efeitos devastadores do IRA e fornecer orientações sobre as estratégias de prevenção, bem como o reconhecimento e tratamento precoces. Os esforços devem ser focados em minimizar as causas de IRA, aumentando a consciência da importância de medidas seriadas de creatinina sérica em pacientes de alto risco para IRA, e documentar o volume de urina em pessoas gravemente doentes para obtenção de diagnóstico precoce; até o momento, não há ainda um papel definitivo para outros biomarcadores. Há a necessidade de protocolos para sistematizar a conduta em condições de IRA pré-renal e em infecções específicas. Dados mais precisos sobre a verdadeira incidência e o impacto clínico da IRA ajudarão a melhor conhecer a importância desta doença, a aumentar o conhecimento de IRA por parte dos governantes, dos médicos em geral e de outros profissionais de saúde para ajudar na prevenção da doença. A prevenção é a chave para evitar a pesado ônus de mortalidade e morbidade associada com IRA.

  5. Bronquiolite aguda, uma revisão atualizada

    Werther Brunow de Carvalho

    2007-04-01

    Full Text Available A bronquiolite aguda (BA é um diagnóstico freqüente de internação hospitalar em pediatria, ocasionada principalmente pelo vírus sincicial respiratório (VSR. Ocorre epidemicamente nos meses de outono e inverno. Algumas populações de crianças (recém-nascidos pré-termo, cardiopatia congênita, doença pulmonar crônica, imunocomprometidos, desnutridos, entre outros apresentam maior risco de morbidade e mortalidade. Os vírus multiplicam-se nas células epiteliais ciliadas, e a inflamação e os debris celulares ocasionam obstrução da via aérea, hiperinsuflação, atelectasia localizada, chiado e alterações das trocas gasosas. Não existem evidências definitivas em relação aos tratamentos utilizados para esta doença. O tratamento inclui a utilização de oxigênio, hidratação, beta-2 agonistas por via inalatória, epinefrina racêmica, DNase recombinante, fisioterapia respiratória, entre outros. Medidas profiláticas: administração de anticorpos monoclonais (palivizumab. A maioria das crianças com BA, independentemente da gravidade da doença, recuperam-se sem seqüelas. O curso natural desta doença, habitualmente, varia entre sete a dez dias, mas algumas crianças permanecem doentes por semanas.

  6. Physiology of free radicals

    Stevanović Jelka

    2011-01-01

    Full Text Available Free radicals imply that every atom, molecule, ion, group of atoms, or molecules with one or several non-paired electrons in outer orbital. Among these are: nitrogenoxide (NO•, superoxide-anion-radical (O2•-, hydroxyl radical (OH•, peroxyl radical (ROO•, alcoxyl radical (RO• and hydroperoxyl radical (HO2•. However, reactive oxygen species also include components without non-paired electrons in outer orbital (so-called reactive non-radical agents, such as: singlet oxygen (1O2, peroxynitrite (ONOO-, hydrogen-peroxide (H2O2, hypochloric acid (eg. HOCl and ozone (O3. High concentrations of free radicals lead to the development of oxidative stress which is a precondition for numerous pathological effects. However, low and moderate concentrations of these matter, which occur quite normally during cell metabolic activity, play multiple significant roles in many reactions. Some of these are: regulation of signal pathways within the cell and between cells, the role of chemoattractors and leukocyte activators, the role in phagocytosis, participation in maintaining, changes in the position and shape of the cell, assisting the cell during adaption and recovery from damage (e.g.caused by physical effort, the role in normal cell growth, programmed cell death (apoptosis and cell ageing, in the synthesis of essential biological compounds and energy production, as well as the contribution to the regulation of the vascular tone, actually, tissue vascularization.

  7. Síndrome de Guillain-Barré associada a pancreatite aguda: relato de caso

    GRZESIUK ANDERSON KUNTZ; SANTOS LUIZ AUGUSTO DOS

    1999-01-01

    Relatamos um caso clínico de síndrome de Guillain-Barré associada a pancreatite aguda, e realizamos revisão na literatura sobre complicações clínicas relacionadas à síndrome de Guillain- Barré. Sugerimos estarem os eventos clínicos relacionados imunologicamente.

  8. Síndrome de Guillain-Barré associada a pancreatite aguda: relato de caso

    GRZESIUK ANDERSON KUNTZ

    1999-01-01

    Full Text Available Relatamos um caso clínico de síndrome de Guillain-Barré associada a pancreatite aguda, e realizamos revisão na literatura sobre complicações clínicas relacionadas à síndrome de Guillain- Barré. Sugerimos estarem os eventos clínicos relacionados imunologicamente.

  9. Efectividad de la magnetoterapia como tratamiento en pacientes con lumbalgia aguda

    Raidel González Rodríguez

    2015-05-01

    Full Text Available Son numerosos los pacientes aquejados de algias vertebrales, tanto lumbares como dorsales y cervicales. Se realizó esta investigación con el objetivo de determinar la efectividad de la magnetoterapia como tratamiento en la lumbalgia aguda, en pacientes atendidos en el policlínico universitario “Raúl Sánchez” de la provincia de Pinar del Río, Cuba. Se realizó un estudio descriptivo, prospectivo, de corte transversal en pacientes con lumbalgia aguda, pertenecientes a dicha área de salud. La muestra quedó conformada por 68 pacientes de ambos sexos con lumbalgia aguda, diagnosticados clínicamente y mayores de 17 años de edad. En la investigación predominó el sexo femenino (67,6 % y el rango de edad estuvo entre 40 y 49 años. El esfuerzo físico fue el principal factor desencadenante (47,1 %. Con el tratamiento de la magnetoterapia aplicado a los pacientes se redujeron los estadios del dolor. La mayoría de los pacientes presentaron una respuesta clínica excelente y mejoraron los síntomas entre los siete y diez días (61,8 %. No se reportaron efectos adversos. La magnetoterapia resultó efectiva en el tratamiento de pacientes aquejados de lumbalgia aguda

  10. Incidencia de la enfermedad diarreica aguda en menores de cinco años

    Mayelín Ávila Labrada

    2015-05-01

    Full Text Available La enfermedad diarreica aguda es motivo frecuente de consulta pediátrica, representando un problema grave de salud pública. Los agentes infecciosos son causa frecuente de diarrea aguda. Se realizó un estudio descriptivo, retrospectivo sobre la prevalencia de la enfermedad diarreica aguda en menores de cinco años, atendidos en la clínica “Simón Bolívar” en la ciudad de Mariara del municipio Diego Ibarra, Carabobo, Venezuela; en el periodo comprendido entre enero de 2008 y diciembre de 2012, lo cual ofreció información de cinco años completos. La prevalencia de la enfermedad diarreica aguda disminuyó significativamente en el intervalo 2009-2011, sin embargo, se caracterizó por tener la mayor prevalencia en los años extremos, 2012 y 2008, por ese orden. Los varones y los del grupo de uno a cuatro años fueron los que más incidieron en cada uno de los años estudiados

  11. Radical chemistry of artemisinin

    Denisov, Evgenii T; Solodova, S L; Denisova, Taisa G [Institute of Problems of Chemical Physics, Russian Academy of Sciences, Chernogolovka, Moscow Region (Russian Federation)

    2010-12-29

    The review summarizes physicochemical characteristics of the natural sesquiterpene peroxide artemisinin. The kinetic schemes of transformations of artemisinin radicals under anaerobic conditions are presented and analyzed. The sequence of radical reactions of artemisinin in the presence of oxygen is considered in detail. Special emphasis is given to the intramolecular chain oxidation resulting in the transformation of artemisinin into polyatomic hydroperoxide. The kinetic characteristics of elementary reaction steps involving alkyl, alkoxyl, and peroxyl radicals generated from artemisinin are discussed. The results of testing of artemisinin and its derivatives for the antimalarial activity and the scheme of the biochemical synthesis of artemisinin in nature are considered.

  12. Radical cystectomy in eldery

    Bančević Vladimir; Aleksić Predrag; Milović Novak; Spasić Aleksandar; Kovačević Božidar; Toševski Perica; Čampara Zoran; Milošević Radovan; Cerović Snežana

    2015-01-01

    Background/Aim. Radical cystectomy is the method of choice for the treatment of muscle invasive bladder cancer. This major surgery is associated with many complications, especially in older patients. The aim of this study was to analyze preoperative comorbidity, and intraoperative and postoperative complicatons in patients older than 75 years. Methods. This clinical, retrospective study included 46 patients over 75 years, who underwent radical cystectomy. I...

  13. Detección molecular de las translocaciones más comunes en Leucemia aguda mediante RT-PCR

    Guevara G.

    2001-06-01

    Full Text Available Evaluar la incidencia de las translocaciones t(4;11, t(1;19, t(9;22 y t(12;21 en leucemia linfoide aguda (LLA y t(15;17, t(8;21 e Inv.(16 en leucemia mieloide aguda (LMA. Correlacionar los resultados obtenidos con el diagnóstico morfológico y citogenético.

  14. Estado oxidante e antioxidante de crianças com bronquiolite aguda

    Rusen Dundaroz

    2013-08-01

    Full Text Available OBJETIVO: O estresse oxidativo demonstrou contribuir para a patogênese de doenças pulmonares inflamatórias agudas e crônicas. Nosso objetivo foi avaliar o estado oxidante/antioxidante de crianças com bronquiolite aguda por meio de mensuração da capacidade antioxidante total do plasma, estado oxidante total e índice de estresse oxidativo. MÉTODOS: As crianças com bronquiolite aguda encaminhadas para o Departamento de Emergência Pediátrica do hospital universitário entre janeiro e abril 2012 foram comparadas a controles saudáveis de mesma idade. Os pacientes com bronquiolite aguda tiveram essa doença classificada como leve e moderada. O estado oxidante e antioxidante foi avaliado pela mensuração da capacidade antioxidante total do plasma, estado oxidante total e índice de estresse oxidativo. RESULTADOS: Foram incluídas 31 crianças com bronquiolite aguda com idade de três meses a dois anos e 37 crianças saudáveis. O estado oxidante total (EOT foi maior em pacientes com bronquiolite aguda do que no grupo de controle (5,16±1,99 µmol H2O2 em comparação a 3,78±1,78 µmol H2O2 [p = 0,004]. A capacidade antioxidante total (CAT foi significativamente menor em crianças com bronquiolite que no grupo de controle (2,51±0,37 µmol Trolox equivalente/L em comparação a 2,75±0,39 µmol Trolox Eqv/L (p = 0,013. Os pacientes com bronquiolite moderada apresentaram níveis de EOT mais elevados que os com bronquiolite leve e os do grupo de controle (p = 0,03, p < 0,001. Os pacientes com bronquiolite moderada apresentaram níveis de IEO mais elevados que os do grupo de controle (p = 0,015. O nível de saturação de oxigênio de pacientes com bronquiolite foi inversamente correlacionado ao nível de EOT (r = -0,476, p < 0,05. CONCLUSÃO: O equilíbrio entre os sistemas oxidante e antioxidante é interrompido em crianças com bronquiolite moderada, indicando que o fator de estresse poderá ter um papel na patogênese da doença.

  15. Esofagitis necrosante aguda: análisis retrospectivo Acute esophageal necrosis: a retrospective case series

    R. Ramos

    2008-09-01

    Full Text Available Introducción: la esofagitis necrosante aguda es una entidad rara. Se reconoce por el aspecto negro difuso del esófago a la endoscopia. Su incidencia e patogénesis se desconoce. Pacientes y métodos: se analizaron retrospectivamente 11 pacientes con esofagitis necrosante aguda desde el punto de vista de los datos clínicos, de laboratorio y endoscopicos en 2 años. Resultados: se analizaron las endoscopias realizadas a 3.976 pacientes, observándose esofagitis necrosante aguda en 11 pacientes. El estado nutricional era malo en 6 pacientes. La resolución completa de la esofagitis se observó en cuatro pacientes. Durante el seguimiento se observó una estenosis en un paciente y un nuevo episodio de esofagitis necrosante aguda en otro paciente. Siete pacientes fallecieron, pero esta elevada mortalidad parece deberse a las enfermedades de base y no es atribuible a las lesiones de la esofagitis necrosante. Conclusiones: la incidencia de esofagitis necrosante aguda en nuestra serie fue 0,28%. La esofagitis necrosante aguda tiene una elevada mortalidad.Background: acute esophageal necrosis has been considered a rare event. It is defined as the presence of diffuse dark pigmentation of the esophagus on upper endoscopy. Its incidence has not yet been established. The pathogenesis remains unknown. Patients and methods: a retrospective analysis of clinical, laboratory, endoscopic, and histological data, and of the clinical course of 11 patients with acute necrotizing esophagitis was carried out over a 2-year period. Results: among 3,976 patients who underwent upper endoscopy, 11 (0.28% with acute esophageal necrosis were identified. Nutritional status was poor for 6 patients. Complete resolution of acute esophageal necrosis without further recurrence was observed in 4. One stricture appeared during follow-up and other patient developed new-onset acute esophageal necrosis. Seven patients died, but no death was directly related to acute esophageal necrosis

  16. RENDIMIENTO Y RECUPERACIÓN AGUDA EN CORREDORES DE RESISTENCIA

    D. A. Boullosa

    2010-09-01

    Full Text Available

     

    RESUMEN

    Dieciséis corredores de fondo bien entrenados fueron evaluados en dos días diferentes mediante la prueba de carrera en pista de la Universidad de Montreal (UMTT y el tiempo límite a la velocidad aeróbica máxima (Tlim. Se examinó la respuesta de la frecuencia cardiaca y la lactatemia en la recuperación aguda (andando. La frecuencia cardiaca máxima fue diferente entre los dos días de valoración (p = 0,001, resultando superior en el UMTT respecto del Tlim. La recuperación de la frecuencia cardiaca en el primer minuto (RFC1 correlacionó con la velocidad aeróbica máxima (r = 0,611 y r = 0,615, p = 0,012; en el UMTT y el Tlim, respectivamente, correlacionando además los dos valores de RFC1 entre sí  (r = 0,824; p = 0,000. La diferencia en la lactatemia entre la finalización y el minuto diez de la recuperación fue estadísticamente significativa sólo después del UMTT (p = 0,013. Se concluye que: 1 fue hallada una relación moderada entre la recuperación cardiaca y la velocidad aeróbica máxima en corredores de resistencia; 2 la frecuencia cardiaca máxima obtenida en una prueba incremental en el campo es superior a la alcanzada en una prueba de tipo rectangular; 3 el descenso significativo de la lactatemia a los 10 min sólo se observó después del UMTT, lo que sugiere una influencia del protocolo de carrera en este parámetro.
    Palabras Clave: frecuencia cardiaca, lactato, recuperación, velocidad aeróbica máxima

     

    ABSTRACT

    Sixteen well-trained endurance runners were evaluated in two different days with the Université de Montréal Track Test (UMTT, and the time limit at maximum aerobic

  17. Free Radical Reactions in Food.

    Taub, Irwin A.

    1984-01-01

    Discusses reactions of free radicals that determine the chemistry of many fresh, processed, and stored foods. Focuses on reactions involving ascorbic acid, myoglobin, and palmitate radicals as representative radicals derived from a vitamin, metallo-protein, and saturated lipid. Basic concepts related to free radical structure, formation, and…

  18. Hepatitis virales agudas en un hospital de adultos, de 1992 a 2001

    José Acuña; Elizabeth Umaña; Mauricio Saldarriaga; Jorge Mora; Fernando Brenes; Alfredo Martén

    2003-01-01

    Justificación y objetivos: Debido al cambio de la distribución etiológica de las hepatitis virales agudas, percibido en la práctica clínica diaria en el ámbito nacional y confirmado en otros países, se hizo evidente la necesidad de realizar un análisis casuístico de las infecciones virales hepáticas agudas en nuestro país. Se puso enfasis en el virus productor de hepatitis Acuya presentación clínica es más severa en adultos en comparación con los niños. Métodos: Se registraron todos los casos...

  19. Gangs, Terrorism, and Radicalization

    Scott Decker

    2011-01-01

    Full Text Available What can street gangs tell us about radicalization and extremist groups? At first glance, these two groups seem to push the boundaries of comparison. In this article, we examine the important similarities and differences across criminal, deviant, and extremist groups. Drawing from research on street gangs, this article explores issues such as levels of explanation,organizational structure, group process, and the increasingly important role of technology and the Internet in the context of radicalization. There are points of convergence across these groups, but it is important to understand the differences between these groups. This review finds little evidence to support the contention that American street gangs are becoming increasingly radicalized. This conclusion is based largely on organizational differences between gangs and terror groups.

  20. Sexuality Following Radical Prostatectomy

    Fode, Mikkel; Serefoglu, Ege C; Albersen, Maarten;

    2016-01-01

    INTRODUCTION: Radical prostatectomies can result in urinary incontinence and sexual dysfunction. Traditionally, these issues have been studied separately, and the sexual problem that has received the most focus has been erectile dysfunction. AIM: To summarize the literature on sexually related side...... effects and their consequences after radical prostatectomy and focus on the occurrence and management of problems beyond erectile dysfunction. METHODS: The literature on sexuality after radical prostatectomy was reviewed through a Medline search. Original research using quantitative and qualitative...... methodologies was considered. Priority was given to studies exploring aspects of sexuality other than erectile function. MAIN OUTCOME MEASURES: The prevalence, predictive factors, and management of post-prostatectomy sexual problems beyond erectile dysfunction. RESULTS: Most patients will develop urinary...

  1. Populismo radical y fragilidad democrática

    Andrés Benavente Urbina

    2005-12-01

    Full Text Available El Populismo Radical – también llamado populismo revolucionario – es planteado por el autor como una amenaza a la democracia en América Latina, en cuanto instrumentaliza problemas económicos y sociales reales para confrontarse con el sistema institucional. En la primera parte del artículo aborda el plano conceptual, proponiéndose una caracterización tanto para el populismo clásico como para el populismo radical. En la segunda, se hace un estudio de los dos casos en que, durante el año 2005, las movilizaciones sociales, que a su vez eran expresiones del populismo revolucionario, provocaron agudas crisis de gobernabilidad en Bolivia y Ecuador, precipitando cambios de gobierno en dichos países. La tercera parte, a manera de conclusión, vincula a las expresiones del populismo radical o revolucionario con la fragilidad de las democracias de la región latinoamericana, y por lo mismo, compartiendo las premisas de la Secretaria de Estado norteamericana Condoleezza Rice, el autor sostiene la necesidad de proteger la democracia con mecanismo efectivos y no meramente declarativos, dado que llama la atención la omisión de la comunidad internacional ante las movilizaciones sociales violentas y rupturistas que atentan en contra del ordenamiento institucional democrático, como ha ocurrido doblemente en Bolivia, argumentando que no se ha producido un quiebre de la Constitución en cuanto funcionan los mecanismos sucesorios regulares. La democracia no es sólo la apelación formal a tales mecanismos, sino el cabal respeto al Estado Derecho y la efectiva vigencia de las libertades personales.

  2. Toxicidade aguda e atividade antibacteriana dos extratos de Tropaeolum majus L.

    Zanetti, Gilberto Dolejal; Manfron, Melânia Palermo; Hoelzel, Solange Cristina da Silva Martins; Morel, Ademir Farias; Pagliarin, Vera Pereira

    2003-01-01

    Foi determinada a toxicidade aguda via oral e a ação antibacteriana por bioautografia, frente a bactérias Gram-positivas e Gram-negativas, de extratos de Tropaeolum majus L., planta reconhecida como medicinal. Nao foram observados sinais de toxicidade do extrato aquoso e etanólico 70%. As frações hexânica e clorofórmica do extrato etanólico 70%, apresentaram atividade contra os microrganismos testados.

  3. Primeiro consenso brasileiro do tratamento da fase aguda do acidente vascular cerebral

    2001-01-01

    Full Text Available Este texto apresenta a síntese das conclusões do Iº Consenso Brasileiro do Tratamento da Fase Aguda do Acidente Vascular Cerebral (AVC. Tratou-se de reunião patrocinada e coordenada pela Sociedade Brasileira de Doenças Cerebrovasculares, com neurologistas especializados nas doenças cerebrovasculares, que analisaram os principais itens da conduta dos AVC.

  4. Sertralina e pancreatite aguda: relato de caso Sertraline and acute pancreatitis: a case-report

    André Malbergier

    2004-03-01

    Full Text Available A pancreatite aguda é uma patologia grave e com considerável morbidade e mortalidade. Vários fatores são apontados como possíveis causas de pancreatite aguda. Neste relato, será apresentado um caso de pancreatite aguda com possível associação causal com um inibidor seletivo de recaptura de serotonina: sertralina. Após um mês de tratamento com sertralina, uma paciente do sexo feminino, 55 anos, desenvolveu forte dor abdominal e elevação da amilase sérica. Após internação e retirada da sertralina, seus sintomas remitiram e os níveis de amilase voltaram ao normal. Pela potencial gravidade do quadro e pelo amplo uso desta medicação, tal associação deve ser lembrada em investigações de casos de pancreatite aguda.Acute pancreatitis is a severe disease with considerable morbidity and mortality. Many risk factors are causally related to acute pancreatitis. In this report, a case of acute pancreatitis with possible causal relationship with the use of a selective serotonin reuptake inhibitor, sertraline, will be discussed. After one month of treatment with sertraline, a female patient, 55 years-old, developed a severe abdominal pain and showed a serum amylase elevation. She was admitted to the hospital and the use of sertraline was interrupted. After that, the symptoms remitted and the serum amylase level returned to normal. Because of the potential severity of this disease and the widespread use of sertraline, this association should be reminded when investigating possible causes for acute pancreatitis.

  5. Citarabina y reacciones cutáneas en leucemia aguda mieloide

    Sofía Grille; Regina Guadagna; Matilde Boada; Victoria Irigoin; Mariana Stevenazzi; Cecilia Guillermo; Lilián Díaz

    2013-01-01

    La citarabina es un antimetabolito utilizado en el tratamiento de las leucemias agudas mieloides (LAM). Esta droga presenta numerosos efectos adversos (mielosupresión, toxicidad en sistema nervioso central, hepática, gastrointestinal, ocular y cutánea). La toxicidad dermatológica es habitualmente descrita como rara, sin embargo existen diferencias en la incidencia comunicada. Se realizó un estudio retrospectivo donde se incluyeron todas las LAM tratadas con quimioterapia que incluía citarabin...

  6. Manifestacoes orais decorrentes da quimioterapia em criancas portadoras de leucemia linfocitica aguda

    Everton Freitas de Morais

    2014-01-01

    Full Text Available Introdução: A leucemia linfocítica aguda é um dos tipos de câncer mais comuns em crianças e é caracterizada pela produção excessiva e desordenada de leucócitos imaturos na medula óssea. Objetivo: Identificar as manifestações orais mais frequentes em crianças portadoras de leucemia linfocítica aguda sob o tratamento quimioterápico. Metodologia: A pesquisa foi realizada nas bases de dados eletrônicas PubMed/Medline, Science Direct, Scielo e Scopus. Procurou-se por artigos apresentados na íntegra, escritos em português, inglês e espanhol, publicados entre janeiro de 1992 e abril de 2013. Resultados: Dos estudos selecionados primariamente, apenas oito atenderam aos critérios de inclusão. A população avaliada foi um grupo de crianças portadoras de leucemia linfócitica aguda. Todos os estudos realizaram exames intraorais para o diagnóstico das lesões bucais. De acordo com os resultados, as lesões mais frequentes foram mucosite, candidíase, periodontite e gengivite. A condição de saúde bucal dos portadores de leucemia linfócitica aguda variou de acordo com a higiene bucal do paciente. Conclusão: Pacientes com LLA podem apresentar alguma lesão na cavidade oral durante ou após o início da quimioterapia. O cirurgião dentista necessita reconhecer as manifestações orais e intervir na saúde bucal do paciente com LLA, contribuindo e auxiliando no seu tratamento.

  7. Homegrown religious radicalization

    Khawaja, Iram

    and their families. Existing literature and ways of thinking about the social psychological process of radicalization will be reviewed, such as social identity theory and transformative learning theory, and a theoretical framework based on a focus on belonging, recognition and the sense of community......It has been reported that a growing number of youngsters from Western Europe are engaging in conflicts motivated by religious and political conflicts in the Middle East. This paper aims at exploring the reasons behind this seemingly religious radicalization from the point of view of the youngsters...

  8. Violent Radicalization in Europe

    Dalgaard-Nielsen, Anja

    2010-01-01

    When, why, and how do people living in a democracy become radicalized to the point of being willing to use or directly support the use of terrorist violence against fellow citizens? This question has been at the center of academic and public debate over the past years as terrorist attacks...

  9. Radical School Reform.

    Gross, Beatrice, Ed.; Gross, Ronald, Ed.

    This book provides a comprehensive examination of the nature of the school crisis and the ways in which radical thinkers and educators are dealing with it. Excerpts from the writings of Jonathan Kozol, John Holt, Kenneth Clark, and others are concerned with the realities of education in ghettos and suburbs. Paul Goodman, Marshall McLuhan, Sylvia…

  10. Radically enhanced molecular recognition

    Trabolsi, Ali

    2009-12-17

    The tendency for viologen radical cations to dimerize has been harnessed to establish a recognition motif based on their ability to form extremely strong inclusion complexes with cyclobis(paraquat-p-phenylene) in its diradical dicationic redox state. This previously unreported complex involving three bipyridinium cation radicals increases the versatility of host-guest chemistry, extending its practice beyond the traditional reliance on neutral and charged guests and hosts. In particular, transporting the concept of radical dimerization into the field of mechanically interlocked molecules introduces a higher level of control within molecular switches and machines. Herein, we report that bistable and tristable [2]rotaxanes can be switched by altering electrochemical potentials. In a tristable [2]rotaxane composed of a cyclobis(paraquat-p-phenylene) ring and a dumbbell with tetrathiafulvalene, dioxynaphthalene and bipyridinium recognition sites, the position of the ring can be switched. On oxidation, it moves from the tetrathiafulvalene to the dioxynaphthalene, and on reduction, to the bipyridinium radical cation, provided the ring is also reduced simultaneously to the diradical dication. © 2010 Macmillan Publishers Limited. All rights reserved.

  11. On Radical Feminism

    翟良锴

    2015-01-01

    <正>All men are created equal.For centuries,human have been struggling for their rights.Women,as a special social force,are fighting vigorously for their equal rights with men.According to an introduction to feminism,there are three main types of feminism:socialist,reformist and radical(Feminism 101).In order

  12. Radical Financial Innovation

    Robert J. Shiller

    2004-01-01

    Radical financial innovation is the development of new institutions and methods that permit risk management to be extended far beyond its former realm, covering important new classes of risks. This paper compares past such innovation with potential future innovation, looking at the process that produced past success and the possibilities for future financial innovation.

  13. OH radicals in the troposphere

    OH radicals are radicals which determine the photochemistry of the troposphere. The reactivity of OH radicals to organic substances is one of the fundamental criteria for the evaluation of abiotic decomposition. Details are given about the photochemical formation and reaction of OH radicals, the decomposition reactions of organic compounds in the gaseous phase, the determination of the specific rates of OH radical decomposition reactions, measuring methods for the determination of OH radical concentrations in the troposphere, selected results, OH concentration distributions obtained from model calculations, and the influence of trace gases on OH concentrations. A summary, conclusions, and research proposals are attached. (orig./BBR)

  14. Infarto esplénico secundario a pancreatitis aguda Splenic infarction secondary to acute pancreatitis

    J. J. Arenal Vera

    2008-05-01

    Full Text Available Fundamento y objetivo: la estrecha relación anatómica del páncreas con los vasos esplénicos y el bazo es responsable de complicaciones esplénicas en el curso de la pancreatitis aguda. El objetivo es presentar dos casos clínicos de pancreatitis aguda grave que sufrieron infarto esplénico como complicación de la enfermedad pancreática. Pacientes, participantes: en un periodo de tres meses, dos pacientes fueron diagnosticados de infarto esplénico secundario a pancreatitis aguda. En ambos casos el diagnóstico y seguimiento evolutivo del infarto esplénico se hizo a través de tomografía axial computerizada. Resultados: en el primer paciente, las imágenes muestran de forma inequívoca la afectación de la arteria esplénica por el proceso inflamatorio pancreático. En el segundo, no se pudo demostrar afectación de los vasos esplénicos, por lo que la única posible explicación etiológica es un incremento de coagulabilidad intravascular. Conclusiones: sería recomendable añadir las complicaciones esplénicas al conjunto de complicaciones graves extrapancreáticas de la pancreatitis aguda. La tomografía axial computerizada es de gran utilidad para la detección y seguimiento de las complicaciones esplénicas de la pancreatitis aguda.Background and objective: the close anatomic relationship of the pancreas with the splenic vessels and the spleen is responsible for splenic complications in the course of acute pancreatitis. Our objective was to report two cases of severe acute pancreatitis complicated by splenic infarction. Patients: in a three-month period of time two patients were diagnosed with splenic infarction secondary to acute pancreatitis. In both cases splenic infarction diagnosis and follow-up were carried out using computed tomography. Results: in the first case images clearly showed a narrowing of the splenic artery due to the inflammatory pancreatic condition. In the second case no involvement of the splenic vessels could

  15. Free radical transfer in polymers

    For the present study of free-radical transfer in polymers pulse radiolysis and product studies have been carried out in aqueous solutions using thus far only the water-soluble polymers polyacrylic acid, polymethacrylic acid and polyvinyl alcohol. When OH radicals, generated in the radiolysis of N2O-saturated aqueous solutions, react with polymers the lifetime of the polymer radical thus created very much depends on the number of radicals per polymer chain. When there are a large number of radicals per chain their bimolecular decay may be faster than the corresponding (diffusion controlled) decay of monomeric radicals, but when the macromolecule contains only few or even just one radical their lifetime is considerably prolonged. Highly charged polymers such as polyacrylic acid at high pH attain a rod-like conformation which again favors a long lifetime of the radicals. Under such conditions, radical transfer reactions can occur. For example, in polyacrylic acid OH radicals generate two kinds of radicals side by side. The radical in β-position to the carboxylate group converts into the thermodynamically more stable α-radicals by an H-transfer reaction as can be followed by spectrophotometry. Besides radical transfer reactions β-fragmentation reactions occur causing chain scission. Such reactions can be followed in a pulse radiolysis experiment by conductometry, because counter ions are released upon chain scission. Such a process is especially effective in the case of polymethacrylic acid, where it results in a chain depolymerization. An intramolecular H-abstraction is also observed in the γ-radiolysis of polyacrylic acid with the corresponding peroxyl radicals. This causes a chain reaction to occur. The resulting hydroperoxides are unstable and decarboxylate given rise to acetylacetone-like products. In polyvinyl alcohol the peroxyl radicals in α-position to the alcohol function undergo HO2-elimination. This prevents a scission of the polymer chain in the

  16. Toward Radicalizing Community Service Learning

    Sheffield, Eric C.

    2015-01-01

    This article advocates a radicalized theoretical construction of community service learning. To accomplish this radicalization, I initially take up a discussion of traditional understandings of CSL rooted in pragmatic/progressive thought. I then suggest that this traditional structural foundation can be radicalized by incorporating Deborah…

  17. Oligorotaxane Radicals under Orders

    WANG, YUPING; Frasconi, Marco; Liu, Wei-Guang; Sun, Junling; Wu, Yilei; Nassar, Majed S.; Botros, Youssry Y.; Goddard, William A.; Wasielewski, Michael R.; Stoddart, J. Fraser

    2016-01-01

    A strategy for creating foldameric oligorotaxanes composed of only positively charged components is reported. Threadlike components—namely oligoviologens—in which different numbers of 4,4′-bipyridinium (BIPY2+) subunits are linked by p-xylylene bridges, are shown to be capable of being threaded by cyclobis(paraquat-p-phenylene) (CBPQT4+) rings following the introduction of radical-pairing interactions under reducing conditions. UV/vis/NIR spectroscopic and electrochemical investigations sugge...

  18. Oligorotaxane Radicals under Orders

    WANG, YUPING; Frasconi, Marco; Liu, Wei-Guang; Sun, Junling; Wu, Yilei; Nassar, Majed S.; Botros, Youssry Y.; Goddard, William A.; Wasielewski, Michael R.; Stoddart, J. Fraser

    2016-01-01

    A strategy for creating foldameric oligorotaxanes composed of only positively charged components is reported. Threadlike components—namely oligoviologens—in which different numbers of 4,4′-bipyridinium (BIPY^(2+)) subunits are linked by p-xylylene bridges, are shown to be capable of being threaded by cyclobis(paraquat-p-phenylene) (CBPQT^(4+)) rings following the introduction of radical-pairing interactions under reducing conditions. UV/vis/NIR spectroscopic and electrochemical investigations...

  19. Síndrome de Guillain-Barré como complicação de amigdalite aguda

    Cecatto Suzana B.; Garcia Roberta I. D.; Costa Kátia S.; Novais Roberta A B.; Yoshimura Ricardo; Rapoport Priscila B.

    2003-01-01

    A Síndrome de Guillain-Barré é uma polirradiculoneuropatia aguda ou subaguda e geralmente ocorre após uma doença infecciosa ou algum procedimento cirúrgico. A patogênese não é bem conhecida, mas provavelmente apresenta uma base imunológica. O objetivo deste trabalho é relatar um caso de amigdalite aguda de má evolução complicada com a Síndrome de Guillain-Barré. Os autores salientam a raridade do caso, a concomitância do início da infecção aguda com a própria Síndrome e a evolução rápida para...

  20. Comportamento da síndrome coronariana aguda: resultados de um registro brasileiro

    Leopoldo Soares Piegas

    2013-06-01

    Full Text Available FUNDAMENTO: O Brasil carece de registros multicêntricos publicados de síndrome coronariana aguda. OBJETIVO: O Registro Brasileiro de Síndrome Coronariana Aguda é um estudo multicêntrico nacional com objetivo de apresentar dados representativos das características clínicas, e manejo e evolução hospitalares dessa síndrome. MÉTODOS: Participaram 23 hospitais de 14 cidades. Foram elegíveis pacientes que se apresentaram com suspeita de síndrome coronariana aguda nas primeiras 24 horas, com quadro clínico sugestivo, associado a alterações eletrocardiográficas compatíveis e/ou marcadores de necrose. O seguimento foi realizado até o óbito ou a alta hospitalar. RESULTADOS: Entre os anos de 2003 e 2008, foram incluídos 2.693 pacientes com diagnóstico de síndrome coronariana aguda, sendo 864 (32,1% mulheres. O diagnóstico final foi de angina instável para 1.141 (42,4% pacientes, com mortalidade de 3,06% deles; de infarto agudo do miocárdio sem supradesnível de ST para 529 (19,6% pacientes, com mortalidade de 6,8% deles; e de infarto agudo do miocárdio com supradesnível de ST para 950 (35,3% pacientes, com mortalidade de 8,1% deles; tiveram diagnóstico não confirmado 73 (2,7% pacientes, com mortalidade de 1,36% deles. A mortalidade global foi de 5,53%. O modelo de regressão logística múltipla identificou o gênero feminino (OR=1,45, o diabetes melito (OR=1,59, o índice de massa corporal (OR=1,27 e a intervenção coronariana percutânea (OR=0,70 como fatores de risco de óbito, para demografia e intervenções. Um modelo para óbito por complicações maiores identificou choque cardiogênico/Edema Agudo de Pulmão (OR=4,57, reinfarto (OR=3,48, acidente vascular cerebral (OR=21,56, sangramento grave (OR=3,33, parada cardiorrespiratória (OR=40,27 e classe funcional de Killip (OR=3,37. CONCLUSÃO: Os dados do Registro Brasileiro de Síndrome Coronariana Aguda não diferem de outros coletados fora do país. Seus achados poder

  1. Lesión pulmonar aguda producida por transfusión Transfusion-related acute lung injury

    J.M. Añón; García de Lorenzo, A.; Quintana, M.; González, E.; M.J. Bruscas

    2010-01-01

    El término TRALI (transfusion related acute lung injury "lesión pulmonar aguda producida por transfusión") fue acuñado en 1985. Es un síndrome clínico relativamente raro, que puede constituir una amenza para la vida y que se caracteriza por insuficiencia respiratoria aguda y edema pulmonar no cardiogénico durante o después de una transfusión de productos hemáticos. Aunque su verdadera incidencia es desconocida se le ha atribuido un caso por cada 5.000 transfusiones de cualquier producto hemát...

  2. Aspectos disautonômicos da porfiria aguda intermitente: a propósito de seis casos

    Charles P. Tilbery

    1979-06-01

    Full Text Available Foram estudados seis casos de porfiria aguda intermitente, sendo enfocados os aspectos disautonômicos apresentados durante a longa permanência hospitalar dos doentes (média de 64 dias. Foram observados taquicardia sinusal e hipertensão arterial (4 casos, parada cardíaca (3 casos e depressão respiratória (5 casos. Os autores tecem comentários a propósito da fisiopatologia destas alterações e chamam a atenção sobre o prognóstico sombrio da porfiria aguda intermitente.

  3. Classificação de gravidade na pancreatite aguda Classification of severity of acute pancreatitis

    Tercio De Campos; José Gustavo Parreira; José Cesar Assef; Sandro Rizoli; Barto Nascimento; Gustavo Pereira Fraga

    2013-01-01

    De acordo com a Classificação de Atlanta a pancreatite aguda pode ser dividida, baseado em sua severidade, em uma forma leve ou grave. Uma série de aspectos têm sido discutidos nos últimos anos, tais como, quantas categorias de gravidade devem ser consideradas; se o doente com falência orgânica é igual ao doente com necrose infectada; qual o papel da falência orgânica transitória; e como avaliar a falência orgânica. A reunião de revista"Telemedicina Baseada em Evidência - Cirurgia do Trauma e...

  4. Hepatite aguda colestática pelo propiltiouracil: relato de caso

    Mônica Beatriz PAROLIN; Lopes, Reginaldo Werneck; José Ederaldo Queiroz TELLES; Ioshii, Sergio Ossamu, 1960-; Nemer HAJAR

    2000-01-01

    Propiltiouracil é uma droga amplamente utilizada no tratamento do hipertiroidismo. A hepatotoxicidade é um dos efeitos colaterais mais raros e também mais graves associados a ela. Relata-se um caso de hepatite aguda colestática que acomete um jovem de 15 anos em uso de propiltiouracil para tratamento de hipertiroidismo. Causas virais, metabólicas e autoimunes foram excluídas e a biopsia hepática revelou achados histopatológicos sugestivos de hepatite colestática induzida por droga. Com a susp...

  5. Estudio de toxicidad aguda por vía oral de plantas medicinales argentinas

    Gorzalczany, Susana; Rojo, Aníbal; Rondina, Rubén Víctor Daniel; Debenedetti, Silvia Laura; Acevedo, María Cristina Dominga

    1999-01-01

    Se efectuó el estudio de la toxicidad aguda en ratones, por vía oral, de los extractos acuosos liofilizados de 14 plantas medicinales argentinas. La dosis administrada fue 100 veces superior al consumo humano habitual (extracto acuoso equivalente a 14,0 -14,4 g de planta seca/kg de peso corporal). A lo largo de los 15 días de observación, los animales no mostraron alteraciones significativas en el consumo de agua o alimentos. No se produjeron cambios de comportamiento ni modificaciones de con...

  6. Toxicidad aguda de las hojas de Xanthium spinosum en ratones BALB/C

    Arturo Silvero-Isidre; Sergio Morínigo-Guayuán; Aaron Meza-Ojeda; Marcelo Mongelós-Cardozo; Aldo González-Ayala; Susy Figueredo-Thiel

    2016-01-01

    Las hojas de la planta Xanthium spinosum se utilizan culturalmente en Paraguay por sus propiedades medicinales. Se evaluó la toxicidad aguda del extracto de hojas maduras; para el estudio se seleccionaron 35 ratones BALB/C machos que fueron distribuidos en 7 grupos, 6 de ensayo y 1 de control. El extracto fue preparado en concentraciones de 6 y 9% (g/dL); se administró la solución 6% a tres grupos y la solución 9% a los otros tres grupos, con dosis entre 200 y 1000 mg/kg. Al final de 14 días ...

  7. Valor pronóstico de nuevos biomarcadores en insuficiencia cardiaca aguda

    Manzano Fernández, Sergio

    2011-01-01

    El contenido de esta tesis esta basado en 3 trabajos previamente publicados en los que se evalúa el valor pronóstico de dos nuevos biomarcadores de función renal (cistatina C y beta-traza-proteína) y un nuevo biomarcador de remodelado cardiaco (sST2) en pacientes con insuficiencia cardiaca aguda. Los principales hallazgos de estos trabajos fueron: i) los niveles elevados de cistatina C y beta-traza proteína se asociaron de forma independiente con la incidencia de mortalidad y / o reingreso po...

  8. Bronquiolite aguda, uma revisão atualizada Acute bronchiolitis, an updated review

    Werther Brunow de Carvalho; Cíntia Johnston; Marcelo Cunio Fonseca

    2007-01-01

    A bronquiolite aguda (BA) é um diagnóstico freqüente de internação hospitalar em pediatria, ocasionada principalmente pelo vírus sincicial respiratório (VSR). Ocorre epidemicamente nos meses de outono e inverno. Algumas populações de crianças (recém-nascidos pré-termo, cardiopatia congênita, doença pulmonar crônica, imunocomprometidos, desnutridos, entre outros) apresentam maior risco de morbidade e mortalidade. Os vírus multiplicam-se nas células epiteliais ciliadas, e a inflamação e os debr...

  9. Esofagitis necrotizante aguda: Una entidad inusual Acute esophageal necrosis: An unusual entity

    Silvana E. Pramparo; Pablo M. Ruiz; Rogelio Flores Valencia; José Rodeyro (h)

    2010-01-01

    La esofagitis necrotizante aguda (ENA), también denominada esófago negro, es una rara enfermedad poco descripta en la literatura médica. Describimos el caso de un hombre de 80 años, con hemorragia digestiva alta quien desarrolló un esófago negro luego de un episodio de hipotensión. La necrosis fue confirmada histológicamente. Los pacientes se presentan con hematemesis y melena en más del 70% de los casos. Los hallazgos endoscópicos muestran una coloración negruzca de la mucosa esofágica. El d...

  10. Intoxicación aguda por inhalación de Acrilato de Etilo, Lima 2002

    Jeannette Ávila VM; Luis Honorio A; Cecilia Chira C; Helga Samatelo V; Carlos Urbano D

    2005-01-01

    Objetivos: Describir las características clínico-epidemiológicas de los casos de intoxicación aguda por inhalación de acrilato de etilo, ocasionado por el manejo clandestino de un envase con restos de ésta sustancia, en una urbanización del distrito Comas, en Lima, Perú en noviembre del año 2002. Materiales y métodos: Estudio transversal analítico realizado en residentes y población del centro educativo aledaño a la zona del accidente. Se realizó una encuesta a todas las personas expuestas, s...

  11. Pruebas de funcionalismo hepático en pacientes con infección viral aguda

    Yraima Lucia Larreal Espina; Edibel Lisett Andrade Zambrano; Yarenny Enmita Cuevas Ruiz; Andrea Shirley Mendoza Rico; Milagros del Valle Montiel Aguilar; Alegría Cecilia Levy Guiffrida; Nereida Josefina Valero Cedeño

    2012-01-01

    Las hepatitis víricas son producidas principalmente por virus de las hepatitis; sin embargo, otros virus han sido asociados a esta entidad clínica. Con el objeto de estudiar estas alteraciones hepáticas se estudiaron 130 pacientes con síntomas de infección viral aguda. Se les realizó una historia clínica y sus muestras de suero fueron procesadas por técnicas inmunoen-zimáticas y espectrofotométrícas para la determinación de anticuerpos específicos de los distintos virus y para pruebas de func...

  12. Inmunofenotipos aberrantes en leucemias agudas en una población hospitalaria de Buenos Aires

    Viviana Novoa

    2013-02-01

    Full Text Available La citometría de flujo multiparamétrica es el método de elección para la caracterización inmunofenotípica de las células hematopoyéticas clonales presentes en los distintos procesos leucémicos agudos. El objetivo fue analizar la expresión de antígenos de membrana y evaluar la presencia de fenotipos aberrantes en los blastos de pacientes con diagnóstico de leucemia aguda, que permiten el monitoreo de la respuesta al tratamiento. Se revisaron los inmunofenotipos de 364 muestras de pacientes adultos derivadas a nuestro laboratorio en un período de 7 años. El inmunofenotipo se realizó por citometría de flujo con un amplio panel de anticuerpos monoclonales con el que se evaluó la expresión de antígenos de linaje linfoide, mieloide y también antígenos de maduración. De las 364 muestras estudiadas, 60.2% presentaron un fenotipo compatible con leucemia mieloide aguda (LMA, 28.8% con leucemia linfoblástica B (LLA-B, 6.6% con leucemia linfoblástica T (LLA-T y 4.4% con leucemias agudas poco frecuentes. La presencia de fenotipos aberrantes se observó en 89% de los casos, los fenotipos aberrantes identificados fueron: 1 infidelidad de linaje: LMA (54%, LLA-B (40%, LLA-T (29%; 2 ausencia de expresión antigénica: LMA (21%, LLA-B (35%, LLA-T (70%; 3 alteración de la expresión antigénica: LMA (67%, LLA-B (66%, LLA-T (84%; 4 asincronismo madurativo: LMA (26%, LLA-B (37% y 5 fenotipo ectópico: LLA-T 96%. El análisis por citometría de flujo multiparamétrica de las leucemias agudas permitió la identificación de fenotipos aberrantes en la mayoría de nuestros pacientes, que son de utilidad para el monitoreo de la respuesta al tratamiento.

  13. Tratamiento adaptado al riesgo de la leucemia promielocítica aguda con ATRA y quimioterapia

    Montesinos Fernández, Pau

    2016-01-01

    El tratamiento actual de la leucemia promielocítica aguda (LPA) con la combinación de ácido trans-retinóico (ATRA) y quimioterapia proporciona una tasa muy elevada de curaciones. No obstante, aunque estrecho, hay un margen de mejora mediante la reducción de cada una de las diferentes causas de fracaso terapéutico. Dada la heterogeneidad de estas causas de fracaso, planteamos la hipótesis de que un análisis de dichas causas y la identificación de las variables ligadas al paciente, a su enferm...

  14. Inmunofenotipos aberrantes en leucemias agudas en una población hospitalaria de Buenos Aires

    Viviana Novoa; Neri A. Núñez; Orlando G. Carballo; Carmen F. Lessa

    2013-01-01

    La citometría de flujo multiparamétrica es el método de elección para la caracterización inmunofenotípica de las células hematopoyéticas clonales presentes en los distintos procesos leucémicos agudos. El objetivo fue analizar la expresión de antígenos de membrana y evaluar la presencia de fenotipos aberrantes en los blastos de pacientes con diagnóstico de leucemia aguda, que permiten el monitoreo de la respuesta al tratamiento. Se revisaron los inmunofenotipos de 364 muestras de pacientes adu...

  15. Caracterización molecular de las leucemias mieloides agudas de novo

    Ibáñez Company, María Amparo

    2013-01-01

    La secuenciación es la técnica de elección para identificar mutaciones. Sin embargo, tiene un coste elevado, es laboriosa y su sensibilidad es limitada. Recientemente, el nuevo método de análisis de alta resolución con curvas de fusión (High Resolution Melt, HRM) permite detectar de forma rápida y específica mutaciones, polimorfismos y cambios epigenéticos. La leucemia mieloide aguda (LMA) son enfermedades heterogéneas con distintos comportamientos clínicos. El 40-50% de los pacientes no p...

  16. Resultados del tratamiento de leucemia linfoblástica aguda en niños.

    Margarita Quintero de Charry

    2009-01-01

    El objetivo general de este estudio fue evaluar los resultados de las fases de inducción, consolidación y reinducción del tratamiento de la leucemia linfoblástica aguda (LLA), utilizado en el Hospital Universitario del Valle (HUV), durante el período comprendido entre enero, 1993 y abril, 1999. Se estudiaron 2 grupos de niños con LLA: 52 de bajo riesgo y 57 de alto riesgo. Se asignaron a diferentes protocolos de quimioterapia, de acuerdo con los criterios de clasificación de riesgo establecid...

  17. Injúria Renal Aguda no paciente politraumatizado Acute Renal Injury in polytrauma patients

    Thiago Gomes Romano; Paulo Fernando Guimarães Morando Marzocchi Tierno

    2013-01-01

    A Injúria Renal Aguda (IRA) no contexto do paciente politraumatizado ocorre, na maioria das vezes, por uma conjuntura de fatores que passam por eventos correlacionados à ressuscitação volêmica inicial, ao grau de resposta inflamatória sistêmica associada ao trauma, ao uso de contraste iodado para procedimentos diagnósticos, à rabdomiólise e à síndrome compartimental abdominal. Atualmente, passamos por uma fase de uniformização dos critérios diagnósticos da IRA com o Acute Kidney Injury Networ...

  18. Mielitis aguda necrotizante en un paciente con Sida Acute necrotizing myelitis in an AIDS patient

    Corti, M.; I Soto; M. F. Villafañe; B. Bouzas; Duarte, J. M.; C. Yampolsky; R. Schtirbu

    2003-01-01

    Como consecuencia de la infección por el virus de la inmunodeficiencia humana tipo-1 (HIV-1), otros patógenos como citomegalovirus (CMV) y herpes simple tipo 1-2 (HSV 1-2) pueden comprometer tanto el sistema nervioso central como el periférico. Estos agentes pueden involucrar también a la médula espinal y causar una mielitis aguda necrotizante. Esta complicación ocurre por lo general en pacientes con enfermedad HIV/sida avanzada y marcada inmunodeficiencia, con recuentos de linfocitos T CD4+ ...

  19. Toxicidad aguda oral de la o-vainillina Acute oral toxicity of o-vanillin

    Yamisleydi Alonso Moreno; Yoagne María Trapero Quintana

    2008-01-01

    El 2-hidroxi-3-metoxibenzaldehído (o-vainillina) posee una probada actividad anti sickling y una baja actividad hemolítica sobre hematíes SS y normales, por lo que puede ser eficaz en el tratamiento de la anemia drepanocítica, enfermedad genética de alta prevalencia a nivel global. En este sentido se desarrolló un estudio de toxicidad aguda oral, con el objetivo de determinar sus efectos adversos. Se administró una dosis de 2 000 mg/kg de peso corporal a un grupo de ratas (3 hembras y 3 macho...

  20. Síndrome de Gradenigo y trombosis de seno cavernoso secundaria a otitis media aguda

    Pelegrín Hernández, Juan Pablo; Díaz Manzano, José A.; Menasalvas Ruíz, Ana I.; Hellín Meseguer, Diego

    2012-01-01

    [ES] El síndrome de Gradenigo se caracteriza por dolor facial en la zona inervada por el trigémino y una oftalmoplejía externa unilateral (parálisis del VI par craneal) secundaria a petrositis apical aguda, por complicación evolutiva de una otitis media. Se trata de una complicación grave que requiere de un tratamiento inmediato para evitar secuelas permanentes y puede asociarse a otras complicaciones intracraneales como la trombosis del seno cavernoso. Presentamos el caso de un varón de 4 añ...

  1. Polirradiculoneurite aguda e vírus da imunodeficiência adquirida

    Milberto Scaff; Getúlio D. Rabello; PAULO E. MARCHIORI

    1989-01-01

    Polirradiculoneurite aguda possivelmente causada pelo vírus da imunodeficiência humana, tratada com plasmaferese, é relatada em paciente com anticorpos anti-HIV positivos por enzimaimunoensaio, confirmados pelo Western-blot. Este revelou bandas p-24, p-38 (fraca) e p-119. Sem evidências clínicas de AIDS, o paciente desenvolveu manifestações psico-orgânicas e severa neutropenia medicamentosa. São discutidas: a etiologia da manifestação neurológica na ausência de infecções oportunistas, pela aç...

  2. A radical publishing collective: the Journal of Radical Librarianship

    Simon Barron

    2015-01-01

    The Journal of Radical Librarianship is a new open-access journal publishing scholarly work in the field of radical librarianship. The focus on critical approaches to librarianship and anti-marketisation of information is reflected not only in our subject matter but in our publishing model, our licensing model, and our organisational practices. We hope to foster open and engaging discussions about radical approaches to librarianship and information studies.

  3. Oligorotaxane Radicals under Orders.

    Wang, Yuping; Frasconi, Marco; Liu, Wei-Guang; Sun, Junling; Wu, Yilei; Nassar, Majed S; Botros, Youssry Y; Goddard, William A; Wasielewski, Michael R; Stoddart, J Fraser

    2016-02-24

    A strategy for creating foldameric oligorotaxanes composed of only positively charged components is reported. Threadlike components-namely oligoviologens-in which different numbers of 4,4'-bipyridinium (BIPY(2+)) subunits are linked by p-xylylene bridges, are shown to be capable of being threaded by cyclobis(paraquat-p-phenylene) (CBPQT(4+)) rings following the introduction of radical-pairing interactions under reducing conditions. UV/vis/NIR spectroscopic and electrochemical investigations suggest that the reduced oligopseudorotaxanes fold into highly ordered secondary structures as a result of the formation of BIPY(•+) radical cation pairs. Furthermore, by installing bulky stoppers at each end of the oligopseudorotaxanes by means of Cu-free alkyne-azide cycloadditions, their analogous oligorotaxanes, which retain the same stoichiometries as their progenitors, can be prepared. Solution-state studies of the oligorotaxanes indicate that their mechanically interlocked structures lead to the enforced interactions between the dumbbell and ring components, allowing them to fold (contract) in their reduced states and unfold (expand) in their fully oxidized states as a result of Coulombic repulsions. This electrochemically controlled reversible folding and unfolding process, during which the oligorotaxanes experience length contractions and expansions, is reminiscent of the mechanisms of actuation associated with muscle fibers. PMID:27163033

  4. Bursectomy at radical gastrectomy

    Cuneyt; Kayaalp

    2015-01-01

    Radical gastrectomy with extended lymph node dissec tion and prophylactic resection of the omentum, peri toneum over the posterior lesser sac, pancreas and/o spleen was advocated at the beginning of the 1960 s in Japan. In time, prophylactic routine resections of the pancreas and/or spleen were abandoned because of the high incidence of postoperative complications. However omentectomy and bursectomy continued to be standard parts of traditional radical gastrectomy. The bursaomentalis was thought to be a natural barrier against invasion of cancer cells into the posterior part of the stomach. The theoretical rationale for bursectomy was to reduce the risk of peritoneal recurrences by eliminating the peritoneum over the lesser sac, which might include free cancer cells or micrometastases. Over time, the indication for bursectomy was gradually reduced to only patients with posterior gastric wall tumors penetrating the serosa. Despite its theoretical advantages, its benefit for recurrence or survival has not been proven yet. The possible reasons for this inconsistency are discussed in this review. In conclusion, the value of bursectomy in the treatment of gastric cancer is still under debate and large-scale randomized studies are necessary. Until clear evidence of patient benefit is obtained, its routine use cannot be recommended.

  5. Intoxicación aguda por plaguicidas en edades pediátricas. Guatemala, 2011

    Mario Enrique Pla Acevedo

    2015-11-01

    Full Text Available Se realizó un estudio descriptivo retrospectivo de la Intoxicación Aguda por plaguicidas en edades pediátricas en Guatemala, que abarcó el  período de enero hasta diciembre del 2011. La muestra estuvo comprendida por 457 pacientes en edades pediátricas. Se analizaron las variables: edad y sexo, actividad que realizaba en el momento de la intoxicación, tipo de plaguicida, severidad, utilización de equipos de protección y lugar de asistencia médica. Las variables para el análisis de los indicadores fueron obtenidas por el Centro Nacional de Epidemiología. Como resultados fundamentales se observó que la Intoxicación Aguda por plaguicidas afectó principalmente al grupo de edades entre 17 y 19 años. El sexo masculino fue el más perjudicado, el mayor porciento de afectados, según causa, fue accidente de trabajo, con un 68% del total de casos; el tipo de plaguicida más utilizado que provocó intoxicación fue el paraquat; predominó la forma severa en los que no usaron medios de protección y el  lugar de atención médica y de notificación correspondió al hospital.

  6. Mielopatia transversa em adulto portador de leucemia aguda linfoblástica: relato de caso

    Brito José Correia de Farias

    2001-01-01

    Full Text Available Relatamos um caso de mielopatia transversa aguda em paciente masculino de 31 anos de idade, branco, portador de leucemia aguda linfoblástica, subtipo L3 (LLA-L3. Esta é uma forma grave de leucemia e compromete mais crianças em relação aos adultos. Menos de 1% dos pacientes leucêmicos apresentam complicações espinais. No paciente em estudo, a sintomatologia instalou-se de modo abrupto e com as seguintes características: dores nas costas, paraplegia crural flácida e perda das funções sensitivas e vegetativas abaixo do segmento afetado. O diagnóstico etiológico foi estabelecido após a realização dos seguintes exames: hemograma, mielograma, análise do líquido cefalorraqueano e ressonância magnética de coluna dorsal. Foi instituído tratamento específico, que não interferiu com a evolução fatal da doença.

  7. Esofagitis necrotizante aguda en paciente inestable Acute necrotizing esophagitis in an unstable patient

    M. Rodrigo

    2009-04-01

    Full Text Available La esofagitis necrotizante aguda o esófago negro es una afección rara, conocida en la literatura médica desde 1990. Aunque su mecanismo no es del todo conocido, el compromiso isquémico parece ser el factor fisiopatológico fundamental. Cuando la esofagitis necrotizante aguda es un hallazgo en el estudio endoscópico de hemorragia digestiva alta, sin desestabilización hemodinámica, el pronóstico es bueno. Presentamos un caso en el que el diagnóstico de esófago negro fue un mero hallazgo endoscópico, secundario a una situación de inestabilidad hemodinámica subyacente, con resultado fatal.Acute necrotizing esophagitis or black esophagus is a rare affection, described in the medical literature since 1990. Although its mechanism is not fully understood, ischemic compromise appears to be the fundamental physiopathological factor. When acute necrotizing esophagitis is found in the endoscopic study of an upper digestive haemorrhage, the prognosis is good. We present a case in which diagnosis of black esophagus was an endoscopic finding, secondary to a situation of underlying hemodynamic instability, with a fatal outcome.

  8. Nódulo solitario esplénico en paciente con leucemia mieloblástica aguda

    Eva García Alberdi; Fidel Fernández Fernández

    2012-01-01

    Historia clínica: Varón de 65 años, diagnosticado de leucemia mieloblástica aguda en tratamiento con quimioterapia. En el bazo se observa un nódulo único, bien circunscrito, de unos dos centímetros de diámetro

  9. Importancia de la producción local de reactantes de fase aguda mayores en la patogenia de la enfermedad pulmonar obstructiva crónica

    Rojano Broz, Belén

    2016-01-01

    Falta palabras clave Los reactantes de fase aguda (RFA) mayores, proteína C reactiva (PCR) y amiloide A sérico (AAS), tiene un papel relevante durante la reacción aguda del organismo ante diversos estímulos nocivos. La inducción de la expresión de estas moléculas (PCR y AAS), cuya concentración se multiplica por 1000 durante una agresión aguda, se realiza principalmente a nivel hepático a través de un complejo sistema de interacción mediado por diversas citoquinas entre las que tiene...

  10. Indicaciones y resultados de la colecistostomía percutánea como opción terapéutica en la colecistitis aguda

    Molina Rodríguez, José Luis

    2013-01-01

    Introducción La colecistitis, una enfermedad resultante de las complicaciones de la colelitiasis, puede ocurrir en dos maneras: aguda o crónica. La colecistitis aguda requiere un tratamiento urgente, normalmente con antibióticos seguidos de colecistectomía. Si la colecistectomía urgente no puede realizarse, la operación puede diferirse hasta que esté resuelto el episodio agudo y realizarse entonces de manera electiva (1). La causa más frecuente de la colecistitis aguda es la impactación...

  11. Pancreatitis aguda secundaria a hipertrigliceridemia: presentación de dos casos clínicos Acute pancreatitis secondary to hypertriglyceridemia: A report of two cases

    S. J. Jiménez Forero; D. X. Roa Saavedra; M. C. Villalba

    2008-01-01

    La pancreatitis aguda es un proceso inflamatorio reversible. La hipertrigliceridemia como etiología de la pancreatitis aguda varía entre un 1,3 y un 11%, de acuerdo a la literatura, cuando los niveles de triglicéridos alcanzan valores por encima de 1.000 mg/dl; sin embargo, la hipertrigliceridemia se observa en un 12 a un 39% de las pancreatitis agudas como factor asociado. El objetivo del tratamiento médico es aumentar la actividad de la lipoproteinlipasa y aumentar la degradación de los qui...

  12. Radical cystectomy in eldery

    Bančević Vladimir

    2015-01-01

    Full Text Available Background/Aim. Radical cystectomy is the method of choice for the treatment of muscle invasive bladder cancer. This major surgery is associated with many complications, especially in older patients. The aim of this study was to analyze preoperative comorbidity, and intraoperative and postoperative complicatons in patients older than 75 years. Methods. This clinical, retrospective study included 46 patients over 75 years, who underwent radical cystectomy. Indications for surgery, and complications during and after the surgery were followed up. Results. Preoperatively, anemia caused by hematuria was registered in 76% of the patients. In 52% of the patients urine derivation was performed by ileal conduit, in 35% by ureterocutaneostomy and in 13% orthotopic ileal neobladder was created. The average duration of surgery was 190 (120-300 min. A total of 76% of the patients were treated by blood supstitution intraoperatively, average 630 (310-1230 mL. Concerning pathological stage of transitional cell carcinoma of urinary bladder, 26% of the patients had T2, 4% T3a, 52% T3b, and 14% T4a stage. In one case, planocellular carcinoma was diagnosed by patohistological examination, and in 2 cases prostate carcinoma was incidentally found. The average duration of hospitalization was 16 (8-35 days. Conclusion. The main reason for cystectomy in patients over 70 and 80 years was gross hematuria caused by bladder cancer, with consecutive anemia which could not be solved using endoscopic treatment or blood supstitution. As expected, a prolonged stay in hospital after cystectomy, and a higher rate of complications were recorded in this population.

  13. Studies of radiation-produced radicals and radical ions

    The radiolytic oxidation of anti-5-methylbicyclo[2.1.0]pentane gives the 1-methylcyclopentene radical cation as the sole rearrangement product H migration whereas oxidation of its syn isomer results in the highly selective formation of the 3-methylcyclopentene radical cation by methyl group migration. Since exactly the same stereoselectivity of olefin formation was observed in corresponding PET (photosensitized electron transfer) studies in the liquid phase, it is concluded that the rearrangement in this case also occurs through the intermediacy of radical cations. Clearly, the radical cation rearrangement must occur very rapidly (10-8--10-9s) under liquid-phase conditions at room temperature to compete with back electron transfer, and therefore the hydrogen (or methyl) migration is a fast process under these conditions. An intramolecular cycloaddition reaction was demonstrated in the radical cation rearrangement of 4-vinylcyclohexene to bicyclo[3.2.1]oct-2-ene. ESR studies show that the radiolytic oxidation of quadricyclane in Freon matrices under conditions of high substrate dilution leads to the bicyclo[3.2.0]hepta-2,6-diene radical cation as well as the previously reported norbornadiene radical cation, the former species predominating at sufficiently low concentrations

  14. Pancreatite aguda em pediatria: revisão sistemática da literatura

    Eduardo Mekitarian Filho

    2012-04-01

    Full Text Available OBJETIVO: Descrever os principais aspectos epidemiológicos, clínicos, diagnósticos e do tratamento de crianças com pancreatite aguda. FONTES DOS DADOS: Realizada revisão sistemática das bases de dados MEDLINE e SciELO nos últimos 5 anos sobre pancreatite aguda em crianças, bem como consultadas referências relevantes dos textos obtidos. SÍNTESE DOS DADOS: Os casos de pancreatite aguda em crianças recebem crescente atenção nos últimos anos, sendo verificado um aumento na incidência da doença em diversos estudos. As principais etiologias em crianças envolvem doença biliar, pancreatite secundária a medicamentos, pancreatite hereditária recorrente e trauma, sendo até 30% dos casos sem etiologia definida. O diagnóstico baseia-se na combinação de aspectos clínicos, laboratoriais com elevação das enzimas acinares e testes radiológicos. Tratamento de suporte inicial, com reposição volêmica adequada e correção dos distúrbios metabólicos, além de terapêutica nutricional específica, são os pontos fundamentais no manejo dos quadros agudos. Complicações a longo prazo são incomuns, e as taxas de mortalidade, inferiores às da população adulta. CONCLUSÃO: O diagnóstico precoce e o manejo apropriado podem contribuir para a melhor evolução da criança com pancreatite e prevenir as complicações imediatas e tardias relacionadas à doença. Mais estudos são necessários para melhor elucidar aspectos relacionados ao diagnóstico clínico e radiológico da pancreatite em crianças, bem como aspectos da terapêutica nutricional nessa faixa etária.

  15. Diagnóstico laboratorial das leucemias linfóides agudas

    Farias Mariela Granero; Castro Simone Martins de

    2004-01-01

    A leucemia linfóide aguda (LLA) é a forma mais comum de câncer na infância, compreendendo 70% dos casos; em adultos a incidência é de apenas 20%. A abordagem inicial do diagnóstico consiste no exame citomorfológico do sangue periférico e da medula óssea. O estudo imunofenotípico eleva para 99% o percentual de casos corretamente classificados, permitindo identificar a linhagem celular (T ou B) e os diferentes estágios de maturação da célula. Aproximadamente 20% dos casos são de origem de célul...

  16. Estudio preliminar de la toxicidad aguda del sulfato y del cloruro de berberina

    Edward J. Acero M.

    2010-07-01

    Full Text Available Se realizaron ensayos para determinar la Toxicidad Aguda (LD50 del Sulfato de Berberina en Hámster dorado administrado tópicamente, y del Cloruro de Berberina administrado vía subcutánea. No se halló LD 50 para el Sulfato de Berberina, y la evaluación hemática de Colesterol, Urea y transaminasas ALAT y ASAT no presentó modificaciones. El Cloruro de Berberina manifestó una LD 50/24 horas de 640 mg/kg.; también acción hipoglicémica y a nivel de SNC hubo acción depresora. La evaluación histológica de hígado y piel para cada una de las presentaciones permitió establecer normalidad.

  17. Estudio preliminar de la toxicidad aguda del sulfato y del cloruro de berberina

    Edward J. Acero M.; Amador Avila T.; Luis Granobles P.; Stella Torres de Young

    2010-01-01

    Se realizaron ensayos para determinar la Toxicidad Aguda (LD50) del Sulfato de Berberina en Hámster dorado administrado tópicamente, y del Cloruro de Berberina administrado vía subcutánea. No se halló LD 50 para el Sulfato de Berberina, y la evaluación hemática de Colesterol, Urea y transaminasas ALAT y ASAT no presentó modificaciones. El Cloruro de Berberina manifestó una LD 50/24 horas de 640 mg/kg.; también acción hipoglicémica y a nivel de SNC hubo acción depresora. La evaluación histo...

  18. Toxicidad Oral Aguda de un Fertilizante Foliar (Sharp Oral toxicity of a Fertilizer to Foliate)

    Jiménez Parada, Graciela; Arbesún Pérez, Oscar; Puente Zapata, Edgar; Betancourt Hernández, Juan E.; Pérez Andrés, Irela; Pascual Simón, José

    2006-01-01

    Se evaluó la Toxicidad Oral Aguda por el método de las Clases de Toxicidad (CTA), de un fertilizante foliar que se identifica como un fertilizante líquido de acción rápida, se aplica en el suelo o por aspersión foliar de acuerdo con el tipo de planta, de su estado fisiológico y uso. Los resultados se analizaron como indica la metodología de la Organización para la Cooperación y Desarrollo Económico (OECD) # 423. Para este estudio se emplearon como modelo animal ratas Sprague Dawley. Se detec...

  19. Crisis aguda de Asma Bronquial. Diagnóstico y tratamiento estandarizado

    Anelia de la Caridad Rojas-Pérez; Andrés Andrés-atos; Dalila Chacón-Bonet; Mariela Parra-Cruz

    2013-01-01

    Se realizó un estudio prospectivo de intervención en 150 pacientes con diagnóstico de Asma Bronquial que acudieron con crisis aguda al Servicio de Urgencias del Hospital Pediátrico de Holguín, de Enero del 2009 hasta Diciembre del 2010; para evaluar la evolución de los mismos después de la aplicación de Guías de Buenas Prácticas. Se aplicó tratamiento a los pacientes según lo establecido, observando su respuesta. Predominó el grupo de 4 a 8 años del sexo masculino, el 52 % de los pacientes pr...

  20. Variables asociadas a necrosis pancreática en pacientes con Pancreatitis Aguda Grave.

    Durbán Serrano, Lucía; Vilaseca Momplet, Jaume; Benlloch Pérez, Salvador

    2012-01-01

    Hem fet un estudi retrospectiu de 73 adults amb pancreatitis aguda greu recollint variables analítiques i radiològiques a l'ingrés i a les 48h i relacionant-les amb l'existència de necrosi pancreàtica a la TC. Les variables relacionades amb la necrosi van ser: edat, leucòcits, VSG, TP, INR, glucèmia, urea, creatinina, proteïnes, albúmina, LDH, calci, PCR i presència de vessament pleural a la Rx. D'aquestes, el vessament pleural a l'ingrés i la hipoalbuminemia, les xifres altes de LDH i PCR a ...

  1. Doença enxerto versus hospedeiro aguda A- GVHD Acute graft-versus-host disease

    Wellington Azevedo

    2010-01-01

    A doença enxerto contra hospedeiro aguda (A-GVHD) é síndrome sistêmica que acomete pacientes transplantados de medula óssea que recebem linfócitos imuno-competentes. A fisiopatologia do fenômeno é complexa e envolve uma série de respostas de diversos efetores imunológicos a estímulos antigênicos naturais ou que são expressos devido ao dano tecidual provocado pela doença ou pelo condicionamento. A ocorrência desta complicação é frequente em transplantes de medula óssea e determina, em grande p...

  2. INSUFICIENCIA RENAL AGUDA EN EL ANCIANO. CONSIDERACIONES ACERCA DE SU VALORACIÓN Y TRATAMIENTO.

    Musso CG

    2005-01-01

    RESUMEN:La insuficiencia renal aguda (IRA) es un trastorno frecuente en los ancianos a raíz de la senescencia renal, la menor metabolización de los fármacos y la mayor exposición a la polifarmacia y enfermedades sistémicas que ellos padecen. Las siguientes son las principales características de la IRA en el anciano: carácter multifactorial, presentación clínica atípica, fragilidad tubular, patrón de síndrome intermedio y poca fiabilidad del examen físico y de los índices urinarios en la inter...

  3. Ataxia cerebelar aguda na criança Acute cerebellar ataxia in children

    Valeriana Moura Ribeiro

    1968-03-01

    Full Text Available São relatados os casos de 6 crianças com ataxia cerebelar aguda. Admitem os autores a presença de um fator etiológico de caráter viral comum a todos êles, discutindo os mecanismos patogênicos com base nos casos da literatura. A evolução foi favorável em todos os pacientes, com regressão completa da sintomatologia, dentro do período de 6 a 60 dias.Clinical observations of 6 children with acute cerebellar ataxia and respective laboratorial data are reported. Considerations are made in order to support the hypothesis of involving virus. The evolution of the disorder was a nonfatal one and the patients regained normal cerebellar function within a period of 6 to 60 days.

  4. Radical production in biological systems

    This paper describes our effort to develop a metric for radiation exposure that is more fundamental than adsorbed dose and upon which a metric for exposure to chemicals could be based. This metric is based on the production of radicals by the two agents. Radicals produced by radiation in biological systems commonly assumed to be the same as those produced in water despite the presence of a variety of complex molecules. This may explain why the extensive efforts to describe the relationship between energy deposition (track structure) and molecular damage to DNA, based on the spectrum of radicals produced, have not been successful in explaining simple biological effects such as cell killing. Current models assume that DNA and its basic elements are immersed in water-like media and only model the production and diffusion of water-based radicals and their interaction with DNA structures; these models lack the cross sections associated with each macro-component of DNA and only treat water-based radicals. It has been found that such models are not realistic because DNA is not immersed in pure water. A computer code capable of simulating electron tracks, low-energy electrons, energy deposition in small molecules, and radical production and diffusion in water like media has been developed. This code is still in at a primitive stage and development is continuing. It is being used to study radical production by radiation, and radical diffusion and interactions in simple molecular systems following their production. We are extending the code to radical production by chemicals to complement our PBPK modeling efforts. It therefore has been developed primarily for use with radionuclides that are in biological materials, and not for radiation fields

  5. Guest Editorial: Processes of Radicalization and De-Radicalization

    Donatella Della Porta

    2012-05-01

    Full Text Available The study of radicalization and de-radicalization, understood as processes leading towards the increased or decreased use of political violence, is central to the question of how political violence emerges, how it can be prevented, and how it can be contained. The focus section of this issue of the International Journal of Conflict and Violence addresses radicalization and de-radicalization, seeking to develop a more comprehensive understanding of the processes, dynamics, and mechanisms involved and taking an interdisciplinary approach to overcome the fragmentation into separate disciplines and focus areas. Contributions by Pénélope Larzillière, Felix Heiduk, Bill Kissane, Hank Johnston, Christian Davenport and Cyanne Loyle, Veronique Dudouet, and Lasse Lindekilde address repressive settings, legitimacy, institutional aspects, organizational outcomes, and dynamics in Europe, Asia, Africa, and North and South America.

  6. Controvérsias no manejo farmacológico da asma aguda infantil

    Amantéa Sérgio Luís

    2002-01-01

    Full Text Available Objetivos: apresentar uma revisão acerca de questões controversas, relativas ao manejo farmacológico utilizado nos pacientes pediátricos portadores de asma aguda. Fontes dos dados: foram utilizadas informações de artigos publicados em revistas científicas nacionais e internacionais, selecionadas das bases de dados Lilacs e Medline. Síntese dos dados: o artigo foi estruturado em tópicos, apresentando aspectos consensuais no tratamento farmacológico da asma infantil. Questões relacionadas à utilização de inaladores dosimetrados versus nebulizadores, o papel das drogas ß2-adrenérgicas utilizadas pela via endovenosa, bem como das metilxantinas e do sulfato de magnésio, são abordados de maneira crítica. Conclusões: os ß2-agonistas administrados pela via inalatória, associados aos coricosteróides, permanecem o tratamento de eleição para episódios agudos de asma na população pediátrica. Tanto os nebulizadores quanto os inaladores dosimetrados, acoplados a espaçadores, são efetivos para alívio dos sintomas agudos. Pacientes refratários ao tratamento convencional, que evoluem para quadros de asma aguda grave, devem ter considerada a utilização de drogas ß2-agonistas pela via endovenosa, desde que adequadamente monitorizados. Quanto às metilxantinas e ao sulfato de magnésio, devem ser considerados alternativas secundárias para pacientes selecionados.

  7. Toxicidad aguda y crónica del lindano sobre Ceriodaphnia cornuta (Cladocera: Daphniidae

    Jorgelina Juárez

    2011-05-01

    Full Text Available El lindano es un plaguicida organoclorado cuya toxicidad produce efectos nocivos en la salud humana y la biota. El objetivo de este estudio fue evaluar la toxicidad aguda y crónica del lindano sobre el microcrustáceo Ceriodaphnia cornuta. Para las pruebas agudas se empleó un diseño estático, usando 10 neonatos ≤ 24 horas de edad para el control y para cada concentración de lindano (5, 10, 15, 20 y 25 mg/L. Se realizaron tres réplicas de cada tratamiento. Se controló la inmovilización de los individuos a las 48 hs y se calcularon los valores de CL50. Los bioensayos crónicos consistieron en un diseño semi-estático, utilizando 10 neonatos menores de 24 horas de edad (uno por recipiente para el control y para cada concentración subletal del tóxico (0,1; 0,15; 0,2; 0,25 y 0,3 mg/L. Se evaluaron los efectos sobre la supervivencia y reproducción durante 21 días. El valor obtenido de CL50 48 horas fue de 5,293 ± 0,7 mg/L. Los parámetros reproductivos (neonatos por hembra, tamaño de la camada e índice de incremento natural disminuyeron al aumentar la concentración del tóxico evaluado, mientras que el inicio de la madurez sexual se retrasó, demostrando la sensibilidad de los organismos prueba al lindano.

  8. Crisis aguda de Asma Bronquial. Diagnóstico y tratamiento estandarizado

    Anelia de la Caridad Rojas-Pérez

    2013-01-01

    Full Text Available Se realizó un estudio prospectivo de intervención en 150 pacientes con diagnóstico de Asma Bronquial que acudieron con crisis aguda al Servicio de Urgencias del Hospital Pediátrico de Holguín, de Enero del 2009 hasta Diciembre del 2010; para evaluar la evolución de los mismos después de la aplicación de Guías de Buenas Prácticas. Se aplicó tratamiento a los pacientes según lo establecido, observando su respuesta. Predominó el grupo de 4 a 8 años del sexo masculino, el 52 % de los pacientes presentaron crisis ligeras, buena respuesta al uso de broncodilatadores en aerosol, se aplicó la Prednisona por vía oral en la mayoría de los casos que lo requirieron, el 68,7 % realizó tratamiento domiciliario con respuestas controladas y solo en el 31,3 % se decidió ingreso hospitalario lo que permitió arribar a la siguiente conclusión: Con la aplicación de Guías de Buenas Prácticas Clínicas par a el manejo de la exacerbación aguda del Asma Bronquial se logró una clasificación adecuada de la severidad de la misma, buena respuesta a los tratamientos utilizados y disminución de los ingresos hospitalarios.

  9. Intoxicaciones agudas en pacientes mayores de 65 años

    P. Miranda Arto

    2014-04-01

    Full Text Available Fundamento. Los estudios sobre la intoxicación aguda en sujetos de edad avanzada en nuestro país son escasos, a pesar de los riesgos asociados que presenta este grupo de pacientes. Material y métodos. Estudio descriptivo retrospectivo de las intoxicaciones agudas atendidas en el servicio de Urgencias del Hospital Clínico Universitario de Zaragoza entre 1995 y 2009, en pacientes con edad igual o mayor a 65 años. Resultados. Se registraron 762 casos, el 4,74% del total de intoxicados, con una edad media de 74,16 (SD ± 6 años. La vía oral fue la más frecuente (85% y por tipo de intoxicación, la sobredosis de alcohol (28,7%. Junto a éste, las benzodiacepinas (14,3% y los productos cáusticos (11% fueron los principales tóxicos involucrados. El 21% de los pacientes recibieron tratamiento específico antitóxico, no precisando ingreso el 82,4%. Se observó en la evolución temporal una tendencia que apuntaba a la disminución del tratamiento emético y del lavado gástrico y un aumento del carbón activado. La mortalidad de la serie fue del 1,04%. Conclusiones. Las intoxicaciones en pacientes mayores presentan una mayor morbimortalidad, precisando más ingresos y más tentativas autolíticas con resultado de muerte.

  10. Doença enxerto versus hospedeiro aguda A- GVHD Acute graft-versus-host disease

    Wellington Azevedo

    2010-05-01

    Full Text Available A doença enxerto contra hospedeiro aguda (A-GVHD é síndrome sistêmica que acomete pacientes transplantados de medula óssea que recebem linfócitos imuno-competentes. A fisiopatologia do fenômeno é complexa e envolve uma série de respostas de diversos efetores imunológicos a estímulos antigênicos naturais ou que são expressos devido ao dano tecidual provocado pela doença ou pelo condicionamento. A ocorrência desta complicação é frequente em transplantes de medula óssea e determina, em grande parte, a evolução clínica do paciente. Neste capítulo são discutidos aspectos da biologia da doença do enxerto versus hospedeiro aguda, da sua evolução clínica e do manejo profilático e terapêutico deste problema, que pode ser devastador para pacientes submetidos a transplantes alogênicos de medula óssea.Graft versus host disease (A-GVHD is a systemic disease that affects bone marrow transplant patients receiving immunocompetent lymphocytes. The pathophysiology of this phenomenon is complex and involves a number of different effector immune responses to antigenic stimuli that are expressed due to tissue damage caused by disease or conditioning. This complication is frequent in bone marrow transplants and often determines the clinical outcome. In this chapter we discuss aspects of the biology of chronic graft versus host disease, its clinical evolution and the prophylactic and therapeutic management of this problem which can be devastating for patients undergoing allogeneic bone marrow transplantation.

  11. Mielitis aguda necrotizante en un paciente con Sida Acute necrotizing myelitis in an AIDS patient

    M. Corti

    2003-04-01

    Full Text Available Como consecuencia de la infección por el virus de la inmunodeficiencia humana tipo-1 (HIV-1, otros patógenos como citomegalovirus (CMV y herpes simple tipo 1-2 (HSV 1-2 pueden comprometer tanto el sistema nervioso central como el periférico. Estos agentes pueden involucrar también a la médula espinal y causar una mielitis aguda necrotizante. Esta complicación ocurre por lo general en pacientes con enfermedad HIV/sida avanzada y marcada inmunodeficiencia, con recuentos de linfocitos T CD4+ de menos de 50 cél/µL. El cuadro clínico, los cambios en el LCR y las neuroimágenes generan una importante sospecha diagnóstica. Es fundamental el inicio precoz de la terapia antiviral específica. Se presenta un paciente con enfermedad avanzada debida al HIV-1 y mielitis aguda necrotizante por CMV y HSV bajo la forma clínica de síndrome de la cola de caballo.In the setting of HIV infection, cytomegalovirus (CMV and herpes simplex virus type 1-2 (HSV 1-2 can affect both the central and peripheral nervous systems. These agents can involve the spinal cord and produce a necrotizing transverse myelitis. This usually occurs in AIDS patients with severe immunodeficiency: CD4 + lymphocyte counts typically are less than 50 cell/µL. The clinical presentation, CSF and imaging studies can provide a high level of suspicion diagnosis. Prompt initiation of antiviral specific drugs is essential. We report a patient with an acute necrotizing myelitis (cauda equina syndrome secondary to CMV and HSV infections.

  12. Diagnóstico laboratorial das leucemias linfóides agudas

    Farias Mariela Granero

    2004-01-01

    Full Text Available A leucemia linfóide aguda (LLA é a forma mais comum de câncer na infância, compreendendo 70% dos casos; em adultos a incidência é de apenas 20%. A abordagem inicial do diagnóstico consiste no exame citomorfológico do sangue periférico e da medula óssea. O estudo imunofenotípico eleva para 99% o percentual de casos corretamente classificados, permitindo identificar a linhagem celular (T ou B e os diferentes estágios de maturação da célula. Aproximadamente 20% dos casos são de origem de célula T; 75%, precursores de célula B; e 5%, de célula B madura. As técnicas citogenéticas têm contribuído de maneira fundamental para a compreensão da biologia molecular e do tratamento da LLA. As anormalidades cromossômicas, quando associadas ao painel de imunofenotipagem, constituem o parâmetro mais importante para a classificação das leucemias, e, juntamente com outros fatores clínicos e laboratoriais, possibilitam a estratificação dos pacientes em diferentes grupos de risco, tendo importância fundamental para determinar o prognóstico e estabelecer o tratamento adequado. O objetivo deste trabalho é fazer uma revisão bibliográfica dos métodos laboratoriais através dos critérios morfológicos, citoquímicos, imunológicos, citogenéticos e de genética molecular, que são úteis para a classificação e o diagnóstico das leucemias linfóides agudas.

  13. Radioterapia radical en el cáncer de pulmón. Factores predictivos de esofagitis

    Rodríguez de Dios, Núria

    2009-01-01

    El cáncer de pulmón es una de las neoplasias más frecuentes a escala mundial, representa el 15-20% de todas las neoplasias. La radioterapia forma parte del tratamiento radical del cáncer de pulmón, la forma de administración más frecuente, es combinada con la quimioterapia en los estadios de enfermedad localmente avanzada (IIIA-IIIB), lo que supone un 35-40% de los casos en el momento del diagnóstico. La mayor limitación para este tratamiento es la toxicidad aguda esofágica. Los objetivos del...

  14. A 56-year-old woman with ampullary adenocarcinoma and acute pancreatitis Mujer de 56 años con adenocarcinoma de la ampolla de Vater y pancreatitis aguda

    V. M. Santos

    2012-12-01

    Full Text Available A 56-year-old woman was admitted with jaundice, and laboratory data were indicative of pancreatitis, which recurred in spite of adequate clinical and nutritional management. The patient was an overweight diabetic using metformin, who had antecedents of cholelithiasis and recent cholecystectomy. Clinical and laboratory features were not conclusive about the cause of this acute pancreatitis. However, imaging data contributed to diagnosis suspicion, and the histopathology study of the transpapillary biopsy confirmed the ampullary adenocarcinoma. Whipple´s surgery was the procedure of choice, associated with radical lymphadenectomy, followed by an uneventful outcome. Recrudescence of signs and symptoms of acute pancreatitis, with elevated serum levels of bilirrubins and of hepatic canalicular enzymes, should enhance the suspicion index about periampullary tumors. High levels of CA 19-9 can constitute a useful marker of this condition. Transpapillary biopsy can characterize the diagnosis of ampullary malignancies.Se presenta el caso de una mujer de 56 años, que presentaba ictericia y cuyos exámenes de laboratorio fueran indicativos de pancreatitis. Presentó recurrencia a pesar de las medidas clínicas y nutricionales adecuadas. La paciente era diabética, con sobrepeso, tomaba metformina y con antecedentes de colelitiasis y reciente colecistectomía. Los datos clínicos y del laboratorio no fueron concluyentes acerca del origen de esta pancreatitis aguda. Sin embargo, los estudios de imagen contribuyeron a la sospecha del diagnóstico; los estudios de citologia exfoliativa y de biopsia transpapilar confirmaron un adenocarcinoma ampular. La cirugía de Whipple fue el procedimiento de opción, asociado con linfadenectomía radical, con resultado favorable. El recrudecimiento de señales y síntomas de pancreatitis aguda, con niveles séricos elevados de bilirrubina y de enzimas hepáticos debe reforzar el índice de sospecha acerca de tumores

  15. Redox Properties of Free Radicals.

    Neta, P.

    1981-01-01

    Describes pulse radiolysis as a useful means in studing one-electron redox potentials. This method allows the production of radicals and the determination of their concentration and rates of reaction. (CS)

  16. Validade da amilasemia e da lipasemia no diagnóstico diferencial entre pancreatite aguda/crônica agudizada e outras causas de dor abdominal aguda Validity of serum amylase and lipase for the differential diagnosis between acute/acutized chronic pancreatitis and other causes of acute abdominal pain

    Ricardo Custódio Pacheco; Sérgio de Andrade Nishioka; Luiz Carlos Marques de Oliveira

    2003-01-01

    RACIONAL: Várias doenças abdominais podem cursar com aumento de amilasemia e lipasemia. OBJETIVO: Avaliar a validade da amilasemia e lipasemia para os diagnósticos diferenciais entre pancreatite aguda/pancreatite crônica agudizada, doenças das vias biliares, úlcera gastroduodenal perfurada e apendicite aguda. PACIENTES E MÉTODOS: Foram avaliados, prospectivamente, 38 pacientes com pancreatite aguda/pancreatite crônica agudizada, 35 com doenças das vias biliares, 17 com úlcera gastroduodenal p...

  17. Radical polymerization of monoethyl itaconate

    Katsikas Lynne; Nišević Nataša; Ignjatović Milka; Adamović Vladimir; Đakov Tatjana A.; Popović Ivanka G.

    2003-01-01

    The radical polymerization of monoethyl itaconate (MEI) was investigated in bulk and in solution at 60°C using a,a'-azobisisobutyronitrile as initiator. It was established that the obtained polymer poly(monoethyl itaconate) was insoluble in its monomer, implying that the bulk polymerization of MEI was a precipitation polymerization. The polymerization kinetics of MEI were discussed and compared to the polymerization kinetics of structurally similar alkyl itaconates. The homogeneous radical po...

  18. Ecoporn, Irrationalities and Radical Environmentalism

    Măntescu, Liviu

    2016-01-01

    This study explores the ‘irrationalities’ of deep ecology activism in the context of radical environmentalism by using the empirical example of ecoporn. Fuck For Forest is an environmental Non-Governmental Organisation which undertakes fund-raising for re-forestation and forest protection by means of pornography. Following twelve months of ethnographic fieldwork, this study presents first research results on a radical environmental project which does not promote democratic and established pro...

  19. Apendicitis aguda sin enfermedad de Crohn en un paciente con inflamación intestinal. Informe de un caso

    Ernesto Sierra-Montenegro; Eduardo Villanueva-Sáenz; José Luis Rocha-Ramírez; Javier Pérez-Aguirre; José Manuel Fernández-Rivero; René Soto-Quirino

    2008-01-01

    Introducción: La enfermedad de Crohn fue descrita por primera ocasión en 1932; la asociación de apendicitis aguda con esta enfermedad es muy rara y ante afectación del ciego el riesgo de fístula es muy alto. El objetivo fue informar un caso de apendicitis aguda en un paciente con diagnóstico de enfermedad de Crohn. Caso clínico: Mujer de 48 años de edad, con diagnóstico reciente de enfermedad de Crohn quien presentó cuadro clínico de dolor abdominal intenso en fosa iliaca derecha con tratamie...

  20. O papel da fisioterapia respiratória na bronquiolite viral aguda = Role of chest physiotherapy in acute viral bronchiolitis

    Luisi, Fernanda

    2008-01-01

    Conclusões: mesmo que não existem evidências diretas, a fisioterapia respiratória tem sido utilizada na bronquiolite aguda com objetivo de desobstrução, higiene brônquica, prevenção de atelectasias e recrutamento alveolar, podendo contribuir para diminuição da resistência das vias aéreas, promover melhor ventilação-perfusão e diminuir o trabalho ventilatório pela remoção do excesso de muco. São necessários estudos clínicos randomizados, controlados e cegados, que avaliem as técnicas mais modernas, para que se possa definir o papel da fisioterapia respiratória no tratamento da bronquiolite viral aguda

  1. Factores pronósticos en leucemia mieloide aguda: utilidad de los estudios inmunofenotípicos y moleculares

    Perea Durán, Granada

    2011-01-01

    La leucemia mieloide aguda (LMA) es una proliferación neoplásica de células inmaduras de estirpe mieloide que se produce por una alteración en la regulación del crecimiento y la diferenciación de las células hematopoyéticas. Durante las décadas de los 80 y 90 se produjo un avance muy importante en el diagnóstico de la leucemia aguda que ha permitido un mayor refinamiento diagnóstico y por tanto un tratamiento más individualizado de los enfermos. Aproximadamente el 60-80% de los adultos c...

  2. The games radicals play : special issue on free radicals and radical ions

    Walton, John C; Ffrancon Williams

    2015-01-01

    Chemistry and Physics have aptly been described as “most excellent children of Intellect and Art” [1]. Both these “children” engage with many playthings, and molecules rank as one of their first favorites, especially radicals, which are amongst the most lively and exciting. Checking out radicals dancing to the music of entropy round their potential energy ballrooms is surely both entertaining and enlightening. Radicals’ old favorite convolutions are noteworthy, but the new styles, modes and a...

  3. Síndrome de Guillain-Barré como complicação de amigdalite aguda

    Cecatto Suzana B.

    2003-01-01

    Full Text Available A Síndrome de Guillain-Barré é uma polirradiculoneuropatia aguda ou subaguda e geralmente ocorre após uma doença infecciosa ou algum procedimento cirúrgico. A patogênese não é bem conhecida, mas provavelmente apresenta uma base imunológica. O objetivo deste trabalho é relatar um caso de amigdalite aguda de má evolução complicada com a Síndrome de Guillain-Barré. Os autores salientam a raridade do caso, a concomitância do início da infecção aguda com a própria Síndrome e a evolução rápida para a falência respiratória que normalmente ocorre somente em 20% dos casos. O tratamento foi a imunoterapia com rápida recuperação do paciente.

  4. Asma aguda em adultos na sala de emergência: o manejo clínico na primeira hora

    DALCIN PAULO DE TARSO ROTH

    2000-01-01

    Full Text Available Asma é doença com alta prevalência em nosso meio e ao redor do mundo. Embora novas opções terapêuticas tenham sido recentemente desenvolvidas, parece haver aumento mundial na sua morbidade e mortalidade. Em muitas instituições, as exacerbações asmáticas ainda constituem emergência médica muito comum. As evidências têm demonstrado que a primeira hora no manejo da asma aguda na sala de emergência concentra decisões cruciais que podem determinar o desfecho desta situação clínica. Nesta revisão não-sistemática, os autores enfocaram a primeira hora da avaliação e tratamento do paciente com asma aguda na sala de emergência, descrevendo uma estratégia apropriada para o seu manejo. São consideradas as seguintes etapas: diagnóstico, avaliação da gravidade, tratamento farmacológico, avaliação das complicações e decisão sobre onde se realizará o tratamento adicional. Espera-se que estas recomendações contribuam para que o médico clínico tome a decisão apropriada na primeira hora do manejo da asma aguda.

  5. Crystalline bipyridinium radical complexes and uses thereof

    Fahrenbach, Albert C.; Barnes, Jonathan C.; Li, Hao; Stoddart, J. Fraser; Basuray, Ashish Neil; Sampath, Srinivasan

    2015-09-01

    Described herein are methods of generating 4,4'-bipyridinium radical cations (BIPY.sup..cndot.+), and methods for utilizing the radical-radical interactions between two or more BIPY.sup..cndot.+ radical cations that ensue for the creation of novel materials for applications in nanotechnology. Synthetic methodologies, crystallographic engineering techniques, methods of physical characterization, and end uses are described.

  6. Crystalline bipyridinium radical complexes and uses thereof

    Fahrenbach, Albert C.; Barnes, Jonathan C.; Li, Hao; Stoddart, J. Fraser; Basuray, Ashish Neil; Sampath, Srinivasan

    2015-09-01

    Described herein are methods of generating 4,4'-bipyridinium radical cations (BIPY.sup..cndot.+), and methods for utilizing the radical-radical interactions between two or more BIPY.sup..cndot.+ radical cations that ensue for the creation of novel materials for applications in nanotechnology. Synthetic methodologies, crystallographic engineering techniques, methods of physical characterization, and end uses are described.

  7. Peroxy radical partitioning during the AMMA radical intercomparison exercise

    M. D. Andrés-Hernández

    2010-11-01

    Full Text Available Peroxy radicals were measured onboard two scientific aircrafts during the AMMA (African Monsoon Multidisciplinary Analysis campaign in summer 2006. This paper reports results from the flight on 16 August 2006 during which measurements of HO2 by laser induced fluorescence spectroscopy at low pressure (LIF-FAGE and total peroxy radicals (RO2* = HO2+ΣRO2, R = organic chain by two similar instruments based on the peroxy radical chemical amplification (PeRCA technique were subject of a blind intercomparison. The German DLR-Falcon and the British FAAM-BAe-146 flew wing tip to wing tip for about 30 min making concurrent measurements on 2 horizontal level runs at 697 and 485 hPa over the same geographical area in Burkina Faso. A full set of supporting measurements comprising photolysis frequencies, and relevant trace gases like CO, NO, NO2, NOy, O3 and a wider range of VOCs were collected simultaneously.

    Results are discussed on the basis of the characteristics and limitations of the different instruments used. Generally, no data bias are identified and the RO2* data available agree quite reasonably within the instrumental errors. The [RO2*]/[HO2] ratios, which vary between 1:1 and 3:1, as well as the peroxy radical variability, concur with variations in photolysis rates and in other potential radical precursors. Model results provide additional information about dominant radical formation and loss processes.

  8. Peroxy radical partitioning during the AMMA radical intercomparison exercise

    M. D. Andrés-Hernández

    2010-04-01

    Full Text Available Peroxy radicals were measured onboard two scientific aircrafts during the AMMA (African Monsoon Multidisciplinary Analysis campaign in summer 2006. This paper reports results from the flight on 16 August 2006 during which measurements of HO2 by laser induced fluorescence spectroscopy at low pressure (LIF-FAGE and total peroxy radicals (RO2*=HO2+ΣRO2, R= organic chain by two similar instruments based on the peroxy radical chemical amplification (PerCA technique were subject of a blind intercomparison. The German DLR-Falcon and the British FAAM-BAe-146 flew wing tip to wing tip for about 30 min making concurrent measurements on 2 horizontal level runs at 697 and 485 hPa over the same geographical area in Burkina Faso. A full set of supporting measurements comprising photolysis frequencies, and relevant trace gases like CO, NO, NO2, NOy, O3 and a wider range of VOCs were collected simultaneously.

    Results are discussed on the basis of the characteristics and limitations of the different instruments used. Generally, no data bias are identified and the RO2* data available agree quite reasonably within the instrumental errors. The [RO2*]/[HO2] ratios, which vary between 1:1 and 3:1, as well as the peroxy radical variability, concur with variations in photolysis rates and in other potential radical precursors. Model results provide additional information about dominant radical formation and loss processes.

  9. Standard Electrode Potentials Involving Radicals in Aqueous Solution: Inorganic Radicals

    Armstrong, David A.; Huie, Robert E.; Koppenol, Willem H.; Lymar, Sergei V.; Merenyi, Gabor; Neta, Pedatsur; Ruscic, Branko; Stanbury, David M.; Steenken, Steen; Wardman, Peter

    2015-12-01

    Recommendations are made for standard potentials involving select inorganic radicals in aqueous solution at 25 °C. These recommendations are based on a critical and thorough literature review and also by performing derivations from various literature reports. The recommended data are summarized in tables of standard potentials, Gibbs energies of formation, radical pKa’s, and hemicolligation equilibrium constants. In all cases, current best estimates of the uncertainties are provided. An extensive set of Data Sheets is appended that provide original literature references, summarize the experimental results, and describe the decisions and procedures leading to each of the recommendations

  10. Classificação de gravidade na pancreatite aguda Classification of severity of acute pancreatitis

    Tercio De Campos

    2013-04-01

    Full Text Available De acordo com a Classificação de Atlanta a pancreatite aguda pode ser dividida, baseado em sua severidade, em uma forma leve ou grave. Uma série de aspectos têm sido discutidos nos últimos anos, tais como, quantas categorias de gravidade devem ser consideradas; se o doente com falência orgânica é igual ao doente com necrose infectada; qual o papel da falência orgânica transitória; e como avaliar a falência orgânica. A reunião de revista"Telemedicina Baseada em Evidência - Cirurgia do Trauma e Emergência" (TBE-CiTE realizou uma avaliação crítica de artigos relacionados a este tema, considerando três artigos recentes que delinearam duas grandes revisões publicadas nos últimos meses. Estes artigos sugerem a classificação de gravidade em três ou quatro categorias, ao invés de pancreatite aguda leve ou grave, além de discutir qual o melhor escore para avaliar a falência orgânica. As seguintes recomendações foram propostas: (1 A pancreatite aguda deve ser classificada em quatro categorias: leve, moderada, grave e crítica, o que permite uma melhor determinação das características dos doentes; (2 Avaliação de falência orgânica com um escore de gravidade, preferencialmente algum que avalie diretamente cada falência orgânica, tais como o SOFA e o MODS (Marshall. O SOFA parece ter maior acurácia, mas o MODS tem melhor aplicabilidade devido à facilidade de uso.Based on the Atlanta Classification, acute pancreatitis is classified according to its severity in either mild or severe acute pancreatitis. In recent years, several issues regarding acute pancreatitis have been discussed in the literature. These issues include how many categories of severity should be considered; whether or not a patient with organ failure holds similar holds severity of disease and prognosis of a patient with infected necrosis; the role of transient organ failure; and how to evaluate organ failure. The"Evidence-based Telemedicine - Trauma

  11. Radical-Enhanced Chinese Character Embedding

    Sun, Yaming; Lin, Lei; Tang, Duyu; Yang, Nan; Ji, Zhenzhou; Wang, Xiaolong

    2014-01-01

    We present a method to leverage radical for learning Chinese character embedding. Radical is a semantic and phonetic component of Chinese character. It plays an important role as characters with the same radical usually have similar semantic meaning and grammatical usage. However, existing Chinese processing algorithms typically regard word or character as the basic unit but ignore the crucial radical information. In this paper, we fill this gap by leveraging radical for learning continuous r...

  12. Efeitos hemodinâmicos da sobrecarga ventricular direita aguda experimental

    Flávio Brito Filho

    2011-04-01

    Full Text Available FUNDAMENTO: A sobrecarga ventricular direita aguda está associada a situações clínicas de elevada morbimortalidade, tais como: ressecções pulmonares extensas, tromboembolismo pulmonar, transplante pulmonar e edema pulmonar das altitudes. Alguns pontos de sua fisiopatologia permanecem obscuros. OBJETIVO: Avaliar os efeitos hemodinâmicos da sobrecarga ventricular direita aguda experimental em suínos. MÉTODOS: A sobrecarga ventricular direita foi induzida pela oclusão das artérias pulmonares através de ligaduras. Vinte porcos foram utilizados no estudo, sendo alocados em 04 grupos: um controle, não submetido à oclusão vascular pulmonar, e três de sobrecarga ventricular direita submetidos à oclusão das seguintes artérias pulmonares: SVD1 (artéria pulmonar esquerda; SVD2 (artéria pulmonar esquerda e do lobo inferior direito e SVD3 (artéria pulmonar esquerda, do lobo inferior direito e do lobo mediastinal, obstruindo a vasculatura pulmonar em 42, 76 e 82,0% respectivamente. Variáveis de hemodinâmica foram medidas a cada 15 minutos durante a uma hora do estudo. Na análise estatística, foram utilizados ajustes de modelos lineares mistos com estrutura de variâncias e covariâncias. RESULTADOS: Nas comparações intergrupais, houve aumento significativo da frequência cardíaca (p = 0,004, pressão arterial pulmonar média (p = 0,001 e pressão capilar pulmonar (p < 0,0001. Houve redução significativa da pressão arterial média (p = 0,01 e do índice sistólico (p = 0,002. Não houve diferença significativa no índice cardíaco (p = 0,94. CONCLUSÃO: Apesar da intensa sobrecarga ventricular direita promovida pela obstrução de 82,0% da vasculatura pulmonar e pelo aumento significativo da pressão arterial pulmonar não houve disfunção cardiovascular severa e/ou choque circulatório no período estudado.

  13. SINDROME INTERMEDIO: UN PATRÓN TÍPICO DE INSUFICIENCIA RENAL AGUDA EN EL ANCIANO

    Algranati L

    2004-01-01

    Full Text Available Acute renal failure is a frequent entity in the elderly. This is due on one hand to the structural and physiological changes of the aged kidney, and on the other hand to the exposure of this population to polypharmacy and their reduced capability to metabolize drugs. In the present report we present a case of a seventy year-old woman who developed acute renal failure secondary to severe dehydration with a clinical and laboratory pattern of intermediate syndrome: laboratory results compatible with parenchymal renal insufficiency (elevated urinary sodium, plasma urea and creatinine, but with a positive response to hydration. The main characteristics of the aged kidney that predispose to the development of an intermediate syndrome are: the vascular dysautonomy and reduced capability of sodium and water reabsorption. The intermediate syndrome is a typical pattern of pre-renal insufficiency in the elderly. RESUMEN: La insuficiencia renal aguda es frecuente en el anciano. Esto se debe por un lado a los cambios estructurales y funcionales propios del riñón senil, y por otro a la gran exposición que esta población tiene a la polifarmacia, y su reducida capacidad para metabolizar los medicamentos. En este reporte presentamos el caso de una mujer de 70 años que desarrolló una insuficiencia renal aguda secundaria a severa deshidratación, mostrando un patrón clínico y de laboratorio propio de un sindrome intermedio: laboratorios compatibles con una insuficiencia renal parenquimatosa (sodio urinario, uremia y creatininemia elevadas, pero con una respuesta favorable a la hidratación. Las principales características del riñón senil que predisponen al desarrollo del sindrome intermedio: son la disautonomía vascular y la reducida capacidad en la recuperación de sodio y agua El sindrome intermedio es un patrón típico de insuficiencia prerrenal en el anciano.

  14. Plasmaférese como modalidade terapêutica na pancreatite aguda por hipertrigliceridemia

    Felipe Soares Castelliano Lucena de Castro

    2012-09-01

    Full Text Available Pancreatite aguda é uma condição inflamatória manifestada clinicamente por dor abdominal e níveis séricos elevados das enzimas pancreáticas. A hipertrigliceridemia é sua terceira causa mais comum. O presente relato teve por objetivo descrever um caso de pancreatite aguda por hipertrigliceridemia, cuja modalidade terapêutica utilizada foi a plasmaférese. Paciente, gênero feminino, 48 anos, apresentou-se ao hospital com queixa de "dor muito forte na barriga". Relatou início do quadro com náuseas, vômitos e dor abdominal do tipo queimação, iniciada em região epigástrica. Negou febre. Ao exame: obesa, orientada, taquipneica, normotensa, taquicárdica, normocorada, desidratada, afebril, anictérica, acianótica; abdome: distendido, ruídos hidroaéreos presentes, timpânico, doloroso difusamente, porém, principalmente em andar supramesocólico. Aos exames de admissão: triglicerídeo 10.932 mg/dL, colesterol 1.548 mg/dL, amilase 226 mg/dL, lípase 899 mg/dL. A tomografia computadorizada de abdome evidenciou pâncreas aumentado de volume (Balthazar E. Evoluiu com piora do estado geral, sendo encaminhada para o centro de terapia intensiva. Foi realizada plasmaférese sem intercorrências. No 14º dia, teve alta do centro de terapia intensiva indo para enfermaria de gastrenterologia, onde foi reiniciada dieta oral, com boa aceitação. Evoluiu bem, com alta hospitalar no 25º de internação. São necessários níveis elevados de triglicerídeos para causar pancreatite, sendo importante excluir causas mais comuns. A abordagem terapêutica utilizada foi importante para reduzir, rapidamente, a hipertrigliceridemia elevada, evitando, assim, danos tissulares maiores.

  15. PROTEÍNAS DE FASE AGUDA EM CÃES - REVISÃO DE LITERATURA

    VIEIRA , Manuela Cristina

    2014-05-01

    Full Text Available In animals with disorder homeostasis due to infection, inflammation, tissue injury, cancer or immune disorder, there is an acute phase response (APR nonspecific. The APR is an immediate innate immune response, that produces protein mediators, they stand out among the acute phase proteins (APP, which are essential for the restoration of body homeostasis. After the stimulus generated by proinflammatory cytokines, particularly interleukin-1 (IL-1, interleukin-6 (IL-6 and tumor necrosis factor alpha (TNF-α, released by immune cells, the liver synthesizes and releases the majority of APP, which results in an increase in their bloodstream. Recent research has shown that the qualification and quantification of these proteins may aid diagnosis and provide valuable prognostic information and monitoring of diseases. Therefore, we present this review of the literature in order to describe the main PFA in small animals, and also update the veterinarians regarding the evaluation of these proteins in addition to the diagnosis, prognosis and monitoring treatment in dogs. Em animais com distúrbios na homeostase devido à infecção, inflamação, injúria tecidual, neoplasia ou desordem imunológica, há uma resposta de fase aguda (RFA inespecífica. A RFA é uma resposta imune inata imediata que produz mediadores proteicos, e entre eles se destacam as proteínas de fase aguda (PFA, que são indispensáveis para o restabelecimento da homeostasia corporal. Após o estímulo gerado pelas citocinas pró-inflamatórias, principalmente a interleucina-1 (IL-1, interleucina-6 (IL-6 e fator alfa de necrose tumoral (TNF-α, liberadas por células de defesa, o fígado sintetiza e libera a maioria das PFA, o que resulta no seu aumento na corrente sanguínea. Pesquisas recentes têm evidenciado que a qualificação e a quantificação destas proteínas podem subsidiar o diagnóstico e trazer valiosas informações prognósticas e de monitoramento de doenças. Portanto

  16. Laparoscopic radical and partial cystectomy

    Challacombe Ben

    2005-01-01

    Full Text Available Radical cystectomy remains the standard treatment for muscle invasive organ confined bladder carcinoma. Laparoscopic radical cystoprostatectomy (LRC is an advanced laparoscopic procedure that places significant demands on the patient and the surgeon alike. It is a prolonged procedure which includes several technical steps and requires highly developed laparoscopic skills including intra-corporeal suturing. Here we review the development of the technique, the indications, complications and outcomes. We also examine the potential benefits of robotic-assisted LRC and explore the indications and technique of laparoscopic partial cystectomy.

  17. Radical democratic politics and feminism

    Martínez Labrin, Soledad

    2006-05-01

    Full Text Available In the article I present a reflection around the radical democratic project proposed by Chantal Mouffe and Ernesto Laclau. Specifically, I examine the application of the project in the context of the “new social movements” and especially, of feminist movement. I state the need of drawing attention to universalism and essentialism as the main obstacles to generate a collective proposal without margins. Nevertheless, doubts remind about the possibility of building up a feminism tailored by the radical democratic project, in a stage in which the political action of such a movement is characterized by categories that are closed and crystallized

  18. Quantification of a radical beam source for methyl radicals

    A radical beam source for methyl radicals (CH3) was characterized applying ionization-threshold mass spectrometry. The beam source is based on thermal dissociation of methane (CH4) or azomethane (N2(CH3)2) in a heated tungsten capillary. A flux of (3±1)x1013 cm-2 s-1 CH3 radicals is produced using methane as precursor gas and a capillary temperature of 1650 K. Alternatively, a flux of (3±1)x1014 cm-2 s-1 CH3 is produced using azomethane as precursor gas and a capillary temperature of 1150 K. The dominant production of methyl from the precursor methane occurs due to reaction 2 CH4+M→2 CH3+H2+M at the hot tungsten surface. The dominant production of methyl from azomethane occurs due to the reaction N2(CH3)2→2 CH3+N2. Besides methyl radicals, only stable molecules contribute to the emitted flux; within the detection limit, no atomic hydrogen is observed. From the comparison of ionization-threshold mass spectrometry and standard mass spectrometry, it is concluded that the cracking pattern of methane varies with the methane gas temperature. This is explained by the vibrational assisted dissociation of methane

  19. Insuficiência renal aguda em paciente tratada com ATRA e anfotericina B: relato de caso

    Gelcimar Moresco

    2011-06-01

    Full Text Available O presente relato apresenta o caso clínico de uma paciente com leucemia promie-locítica aguda tratada com ácido todo-transretinoico (ATRA, que apresentou suspeita de síndrome do ácido transreti-noico (síndrome de ATRA. Com a ocor-rência de leucopenia febril inespecífica, foram associados ao tratamento antimi-crobianos e antifúngicos. A diminuição da função renal, observada inicialmente, contribuiu para a suspeita de síndrome de ATRA, que foi agravada pelos antifúngi-cos. Assim, o uso de ATRA foi suspenso, mas somente 8 dias depois foi caracteriza-da pneumonia e descartada a hipótese de síndrome de ATRA. Nesse contexto, foi discutida a nefrotoxicidade do ATRA e a potencialização desse efeito adverso pelo uso de antifúngicos nefrotóxicos, em par-ticular da anfotericina B, assim como a im-portância do diagnóstico diferencial entre síndrome de ATRA e doença infecciosa.

  20. Actuación de enfermería en la leucemia mieloide aguda.

    Melchor Pino, Pilar

    2012-08-01

    Full Text Available La leucemia mieloide aguda (LMA es una proliferación neoplásica de células inmaduras de estirpe mieloide que se produce por una alteración en el crecimiento y diferenciación de las células hematopoyéticas.En este trabajo se presenta un caso clínico sobre un paciente de 37 años diagnosticado de LMA. Se hace una valoración de las necesidades básicas siguiendo el modelo de Virginia Henderson al ingreso del paciente, mediante una entrevista dirigida y la obtención de datos mediante la observación.El objetivo general es elaborar un plan individualizado de cuidados a dicho paciente, mediante la aplicación del Proceso Enfermero y la utilización de la taxonomía NANDA-NOC-NIC que nos permitirá aplicar unos cuidados de calidad a este paciente.Cuando el paciente abandone el hospital, la enfermera le entregará un informe de alta, que asegurará la continuidad de sus cuidados.

  1. Consumo alimentar e estresse em pacientes com síndrome coronariana aguda

    Evelise Helena Fadini Reis Brunori

    2015-10-01

    Full Text Available RESUMOObjetivo:Avaliar se o consumo alimentar de pacientes com síndrome coronariana aguda (SCA segue as recomendações nacionais e internacionais e se existe relação com níveis de estresseMétodo:Estudo transversal com 150 pacientes com SCA que foram entrevistados utilizando-se os Questionários de Frequência Alimentar e Escala de Estresse Percebido-10.Resultados:Consumo diário acima das recomendações: colesterol (92%, fi bras (42,7% e proteínas (68%; consumo abaixo das recomendações: potássio (88% e carboidratos (68,7%; consumo conforme recomendações: sódio (53,3% e lípides (53,3%. A maioria (54% com consumo alimentar inadequado era estressada ou altamente estressada. Houve associação estatisticamente signifi cante entre menor nível de estresse e maior consumo de fibras.Conclusão:Em pacientes com SCA, o consumo alimentar esteve fora do recomendado pelas diretrizes e o menor consumo de fibras ocorre concomitantemente com maior estresse. Esforços educativos podem instrumentalizar os pacientes na adequação do consumo alimentar e no controle do estresse.

  2. Toxicidad aguda de las hojas de Xanthium spinosum en ratones BALB/C

    Arturo Silvero-Isidre

    2016-01-01

    Full Text Available Las hojas de la planta Xanthium spinosum se utilizan culturalmente en Paraguay por sus propiedades medicinales. Se evaluó la toxicidad aguda del extracto de hojas maduras; para el estudio se seleccionaron 35 ratones BALB/C machos que fueron distribuidos en 7 grupos, 6 de ensayo y 1 de control. El extracto fue preparado en concentraciones de 6 y 9% (g/dL; se administró la solución 6% a tres grupos y la solución 9% a los otros tres grupos, con dosis entre 200 y 1000 mg/kg. Al final de 14 días de observación, se extrajeron muestras de sangre para estudios laboratoriales de urea y transaminasas, además de órganos para estudios anatomopatológicos. Se determinaron aumentos en los niveles de GOT y urea en comparación al grupo control. Se concluye que el consumo del extracto de hojas maduras de Xanthium spinosum puede causar daño hepático.

  3. Epidemia de esquistossomose aguda na praia de Porto de Galinhas, Pernambuco, Brasil

    Constança Simões Barbosa

    2001-06-01

    Full Text Available Este trabalho notifica a ocorrência de um surto de esquistossomose aguda na praia de Porto de Galinhas, Pernambuco, Brasil, quando 662 pessoas tiveram diagnóstico positivo para Schistosoma mansoni. A infecção humana em massa ocorreu no feriado de 7 de setembro, quando chuvas pesadas provocaram a enchente do rio Ipojuca que invadiu as residências. A maioria dos casos agudos foi representada por famílias de residentes locais que tiveram exposição diária às cercárias durante três semanas, até que as águas baixassem. O inquérito malacológico aponta para a possibilidade dos caramujos vetores terem sido introduzidos na localidade com os aterros realizados em quintais, onde vieram a se reproduzir em criadouros peridomiciliares. A infecção dos moluscos se deu a partir de vazamentos de fossas. Os resultados da clínica e do laboratório apontam para cerca de 62% de casos agudos. Estudos complementares estão sendo realizados, para a melhor compreensão deste evento epidemiológico de significativa magnitude para os órgãos de saúde pública e impacto para a população afetada.

  4. O desafio de diagnosticar tromboembolia pulmonar aguda em pacientes com doença pulmonar obstrutiva crônica The challenge of diagnosing acute pulmonary thromboembolism in patients with chronic obstructive pulmonary disease

    Sérgio Saldanha Menna-Barreto

    2005-01-01

    Tromboembolia pulmonar aguda e exacerbação aguda de doença pulmonar obstrutiva crônica são doenças comuns. A doença pulmonar obstrutiva crônica é um fator clínico de risco para tromboembolia pulmonar aguda. As apresentações clínicas da tromboembolia pulmonar aguda e da exacerbação aguda da doença pulmonar obstrutiva crônica freqüentemente mimetizam-se tanto que pode ser difícil distingui-las. Anormalidades estruturais nos pulmões com doença pulmonar obstrutiva crônica tornam também difícil a ...

  5. Detecting Social Polarization and Radicalization

    Qureshi, Pir Abdul Rasool; Memon, Nasrullah; Wiil, Uffe Kock;

    2011-01-01

    This paper proposes a novel system to detect social polarization and to estimate the chances of violent radicalization associated with it. The required processes for such a system are indicated; it is also analyzed how existing technologies can be integrated into the proposed system to fulfill the...

  6. Exploring the Theories of Radicalization

    Maskaliūnaitė Asta

    2015-12-01

    Full Text Available After the London bombings in July 2005, the concern of terrorism scholars and policy makers has turned to “home-grown” terrorism and potential for political violence from within the states. “Radicalization” became a new buzz word. This article follows a number of reviews of the literature on radicalization and offers another angle for looking at this research. First, it discusses the term “radicalization” and suggests the use of the following definition of radicalization as a process by which a person adopts belief systems which justify the use of violence to effect social change and comes to actively support as well as employ violent means for political purposes. Next, it proposes to see the theories of radicalization focusing on the individual and the two dimensions of his/her motivation: whether that motivation is internal or external and whether it is due to personal choice or either internal (due to some psychological traits or external compulsion. Though not all theories fall neatly within these categories, they make it possible to make comparisons of contributions from a variety of different areas thus reflecting on the interdisciplinary nature of the study of terrorism in general and radicalization as a part of it.

  7. Kinetics of nitroxyl radical reactions

    Absolute rate-constants for the reaction of the nitroxyl free radicals TAN and TMPN with radiation-chemically-formed radicals and ions have been determined. k(TAN + X) (in M-1 sec-1) = 4.0 x 109 (for X =OH), 2.9 x 1010(esub(aq)-), 8.0 x 109 (H), 7.2 x 108 (CH2OH), 4.0 x 108 (CH3CHOH), 4.3 x 108 ((CH3)2COH), 2.8 x 108 (CH2(CH3)2COH), 5.9 x 107 (glucose radical), 4.0 x 108 (c-C5H9), and k(TMPN + X) = 3.4 x 109 (OH), 7.8 x 109 (esub(aq)-), 4.9 x 109 (H), 4.4 x 108 (CH2OH), 4.9 x 108 (CH3CHOH), 3.6 x 108 ((CH3)2COH), 1.5 x 108 (CH2(CH3)2COH), 4.9 x 107 (glucose radical), 4.3 x 108 (c-C5H9). Direct measurements by means of a pulse-radiolysis conductivity technique were based on the formation and destruction of charged species in these reactions within certain pH ranges. It is indicated that the radiosensitizing nitroxyles undergo both redox and addition reactions. (author)

  8. Reaction between protein radicals and other biomolecules

    Østdal, Henrik; Davies, Michael Jonathan; Andersen, Henrik J

    2002-01-01

    The present study investigates the reactivity of bovine serum albumin (BSA) radicals towards different biomolecules (urate, linoleic acid, and a polypeptide, poly(Glu-Ala-Tyr)). The BSA radical was formed at room temperature through a direct protein-to-protein radical transfer from H(2)O(2....... Subsequent analysis showed a decrease in the concentration of urate upon reaction with the BSA radical, while the BSA radical in the presence of poly(Glu-Ala-Tyr) resulted in increased formation of the characteristic protein oxidation product, dityrosine. Reaction between the BSA radical and a linoleic acid...

  9. Orbital abscess secondary to acute dacryocystitis: case report Abscesso orbitário secundário à dacriocistite aguda: relato de caso

    Marcia Clivati Martins

    2008-08-01

    Full Text Available Acute dacryocystitis usually induces preseptal infection. In rare instances the infection that is confined to the lacrimal sac can extend to the orbital contents resulting in orbital cellulitis. We present a case of intraconal abscess secondary to acute dacryocystitis and review the literature of orbital cellulitis resulting from acute lacrimal sac infection.A dacriocistite aguda comumente evolui para infecção pré-septal. Raramente a infecção localizada no saco lacrimal pode estender-se ao conteúdo orbitário resultando em celulite orbitária. Apresentamos um caso de abscesso orbitário intraconal secundário à dacriocistite aguda e uma revisão de literatura de celulite orbitária causada por infecção aguda do saco lacrimal.

  10. From Radical Translation to Radical Interpretation and Back

    António Zilhão

    2003-12-01

    Full Text Available Both Quine and Davidson put forth programs of empirical semantics satisfying the conditions that characterize the so-called “standpoint of interpretation.” Quine’s less ambitious program of radical translation rests upon two buttresses: causality and empathy. Davidson’s more ambitious program of radical interpretation replaces causality with truth and empathy with rationality. Although the replacement of causality with intersubjective truth seems to me to be a fully justified move, I nevertheless contend that it is more realistic to develop the work of interpretation drawing upon Quine’s less ambitious requirement of empathy than upon Davidson’s view of human agency as rational agency. In order to substantiate this contention, I present an argument to the effect that Davidson’s characterization of human agency as rational is not compatible with his other requirement that truth should pro-vide the essential link connecting speech with environment and action.

  11. Neutrophil gelatinase-associated lipocalin (NGAL) como biomarcador de disfunción renal aguda en pacientes postoperados de cirugía cardiaca

    García Álvarez, Mercedes

    2015-01-01

    La disfunción renal aguda (DRA) es una complicación frecuente en el postoperatorio inmediato de cirugía cardiaca; la probabilidad de desarrollarla puede llegar a ser de un 40%. La disfunción renal aguda con necesidad de diálisis (DRA-D), la forma más grave de DRA, tiene una incidencia que alcanza un 5%. El desarrollo de DRA asociada a la cirugía cardiaca (DRA-ACC) tiene un impacto directo en el pronóstico de estos pacientes aumentando la morbi-mortalidad a corto y largo plazo; además se a...

  12. Neutrophil gelatinase-associated lipocalin (NGAL) como biomarcador de disfunción renal aguda en pacientes postoperados de cirugía cardiaca

    García Álvarez, Mercedes; Betbesé Roig, Antoni-Jordi; Rius Cornadó, Xavier

    2015-01-01

    La disfunción renal aguda (DRA) es una complicación frecuente en el postoperatorio inmediato de cirugía cardiaca; la probabilidad de desarrollarla puede llegar a ser de un 40%. La disfunción renal aguda con necesidad de diálisis (DRA-D), la forma más grave de DRA, tiene una incidencia que alcanza un 5%. El desarrollo de DRA asociada a la cirugía cardiaca (DRA-ACC) tiene un impacto directo en el pronóstico de estos pacientes aumentando la morbi-mortalidad a corto y largo plazo; además se asoci...

  13. Valor prognóstico da interleucina-6 na evolução de pacientes com síndrome coronariana aguda sem supradesnivelamento de segmento ST

    Azevedo, Eduardo Mascarenhas et al.

    2006-01-01

    Objetivos: Identificar o valor prognóstico da interleucina-6 (IL-6) em pacientes com síndrome coronariana aguda sem supradesnivelamento de segmento ST internados na Unidade Coronariana do Hospital São Lucas da PUCRS. Métodos: Foram selecionados 90 pacientes consecutivos com síndrome coronariana aguda sem supradesnivelamento de segmento ST, acompanhados por um período médio de 29,4 meses, em busca de desfechos tais como: óbito, infarto agudo do miocárdio, angina instável e cirurgia de revascul...

  14. Síndromes coronarianas agudas na ausência de doença arterial coronariana significativa Acute coronary syndromes in the absence of significant coronary artery disease

    Maria das Graças Viana Pinheiro; Alvaro Rabelo Jr.; Rogerio Santos de Jesus; Luciana Cunha Nascimento; Ursula Maria Moreira Costa

    2005-01-01

    OBJETIVO: Avaliar as características clínicas, a evolução e as complicações intra-hospitalares de pacientes com síndromes coronarianas agudas (SCA) na ausência de doença arterial coronariana (DAC) obstrutiva significativa. MÉTODOS: Estudo transversal envolvendo pacientes internados, de agosto/96 a março/02, com síndromes coronarianas agudas, com e sem supradesnivelamento ST, analisando as características clinicas, demográficas e complicações intra-hospitalares nos casos com (>50%) e sem (< 50...

  15. Uso do sulfato de magnésio venoso para tratamento da asma aguda grave da criança no pronto-socorro

    Tânia Mara Baraky Bittar; Sérgio Diniz Guerra

    2012-01-01

    A asma aguda grave é uma emergência médica que deve ser diagnosticada e tratada rapidamente. O tratamento inicial inclui broncodilatadores e corticosteróides sistêmicos. Em casos graves, com fraca resposta ao tratamento padrão, o sulfato de magnésio venoso surge como opção terapêutica. O objetivo deste artigo foi revisar a literatura sobre o uso do sulfato de magnésio venoso na asma aguda em crianças no pronto-socorro no que se refere a eficácia, indicação, dosagem, efeitos adversos e contrai...

  16. Factores pronósticos en la insuficiencia cardiaca aguda atendida en los servicios de urgencias hospitalarios españoles. Análisis del registro EAHFE.

    Jacob Rodríguez, Fco. Javier

    2012-01-01

    Con el objetivo de contrastar algunas herramientas pronósticas que puedan utilizarse en los pacientes con insuficiencia cardiaca aguda que consultan a un servicio de urgencias, la presente tesis doctoral plantea los siguientes objetivos: 1) Contrastar si la existencia de una ecocardiografía previa a la consulta por episodio de insuficiencia cardiaca aguda puede ser una herramienta pronóstico útil a la hora de establecer el pronóstico en la ICA. . 2) Investigar si el valor de los pép...

  17. Acción analgésica de la digitopuntura previa al tratamiento estomatológico convencional en las pulpitis agudas

    Kenia Betancourt Gamboa; Julio Barciela Calderón; Julio Guerra Menéndez; Lissette Alberti Vázquez; Sonia Rodríguez Ramos

    2011-01-01

    Fundamento: los pacientes con pulpitis aguda, producto al dolor que las caracteriza, en ocasiones no permiten realizar un tratamiento endodóntico de urgencia satisfactorio. Objetivo: evaluar la acción analgésica de la digitopuntura previo al tratamiento estomatológico convencional en las pulpitis agudas. Método: se realizó un estudio de evaluación, cuasi-experimental de tipo antes y después, en la consulta de urgencias estomatológica del policlínico Previsora desde septiembre de 2008 hasta ab...

  18. Supervivencia a largo plazo de los pacientes trasplantados por leucemia mieloblástica aguda. Análisis de los factores de riesgo

    Montes Gaisán, Carmen

    2015-01-01

    RESUMEN: La leucemia mieloblástica aguda (LMA) es un grupo heterogéneo de leucemias con perfiles biológicos y clínicos singulares y diferente pronóstico, englobando desde la Leucemia Promielocítica Aguda que responde a ácido retinoico en combinación con quimioterapia, hasta casos que solo pueden curarse con un procedimiento tan agresivo como es el trasplante alogénico (Alo-TPH). El trasplante autólogo (Auto-TPH) tiene un papel intermedio, con resultados discretamente mejores que la quimiotera...

  19. Evidencia de la fisioterapia del pulmón profundo (postiaux) versus tratamiento convencional en niños con bronquitis vírica aguda

    Barranco Gómez, Miriam

    2014-01-01

    La bronquiolitis vírica aguda supone un grave problema para la sanidad debido a que tiene una elevada prevalencia los primeros años de edad y a los alarmantes costes que supone para la sanidad pública. El objetivo de este estudio es contrastar la eficacia del tratamiento llevado a cabo con las técnicas de fisioterapia respiratoria descritas por Guy Postiaux comparándolo con el tratamiento con técnicas convencionales de fisioterapia respiratoria en pacientes con bronquiolitis vírica aguda. ...

  20. A videolaparoscopia na apendicite aguda na mulher em idade fértil The videolaparoscopy in acute appendicitis in woman of childbearing age

    Cláudio de Oliveira Chiari Campolina; Antônio Sérgio Alves; Álvaro Vieira Júnior; Cláudio Almeida de Oliveira; José Luiz Campelo de Mello Vianna; Marcos Eduardo Valadares Meirelles M. Costa

    1998-01-01

    O diagnóstico de apendicite aguda na mulher em idade fértil é um desafio para o cirurgião devido ao alto índice de explorações cirúrgicas negativas. O objetivo deste trabalho foi estabelecer um índice de probabilidade diagnóstica e o valor da videolaparoscopia nestes casos. Foram analisadas, prospectivamente, 34 mulheres em idade fértil referendadas para o serviço com diagnóstico de apendicite aguda. As pacientes foram submetidas à videolaparoscopia de urgência, e o tratamento cirúrgico, quan...

  1. Mastoiditis aguda: estudio epidemiológico de una década Acute mastoiditis: one-decade long epidemiological study

    C. Suárez Castañón; M. Morán Poladura; R. Pardo de la Vega; C. Pérez Méndez

    2009-01-01

    Objetivos: Describir las características clínicas de los pacientes ingresados por mastoiditis aguda en nuestro hospital.
    Material y métodos: Estudio descriptivo retrospectivo de niños con mastoiditis aguda ingresados en el Hospital de Cabueñes (Gijón), entre enero de 1997 y diciembre de 2007.
    Resultados: Se incluyeron 28 pacientes (54% varones) con edad media de 35,5 meses. Siete casos (25%) ocurrieron en 2007. El 28% de pacientes refería antecedente de otiti...

  2. Avaliação da reprodutibilidade da tomografia computadorizada no estadiamento da pancreatite aguda Reproducibility in the assessment of acute pancreatitis with computed tomography

    Edison de Oliveira Freire Filho; David Carlos Shigueoka; Daniel Bekhor; Renata La Rocca Vieira; André Fukunishi Yamada; Maxime Figueiredo de Oliveira Freire; Sergio Ajzen; Giuseppe D'Ippolito

    2007-01-01

    OBJETIVO: Medir a reprodutibilidade da tomografia computadorizada sem e com contraste na avaliação da gravidade da pancreatite aguda. MATERIAIS E MÉTODOS: Cinqüenta e um exames de tomografia computadorizada abdominal sem e com contraste de pacientes com pancreatite aguda foram analisados por dois radiologistas (observadores 1 e 2). Calculamos o índice morfológico pela tomografia computadorizada sem e com contraste, separadamente, e o índice de gravidade da tomografia computadorizada para panc...

  3. Electron attachment to fluorocarbon radicals

    Shuman, Nicholas

    2014-10-01

    Most plasma environments contain populations of short-lived species such as radicals, the chemistry of which can have significant effects on the overall chemistry of the system. However, few experimental measurements of the kinetics of electron attachment to radicals exist due to the inherent difficulties of working with transient species. Calculations from first principles have been attempted, but are arduous and, because electron attachment is so sensitive to the specifics of the potential surface, their accuracy has not been established. Electron attachment to small fluorocarbon radicals is particularly important, as the data are needed for predictive modeling of plasma etching of semiconductor materials, a key process in the industrial fabrication of microelectronics. We have recently developed a novel flowing afterglow technique to measure several types of otherwise difficult to study plasma processes, including thermal electron attachment to radicals. Variable Electron and Neutral Density Attachment Mass Spectrometry (VENDAMS) exploits dissociative electron attachment in a weakly ionized plasma as a radical source. Here, we apply VENDAMS to a series of halofluorocarbon precursors in order to measure the kinetics of thermal electron attachment to fluorocarbon radicals. Results are presented for CF2, CF3, C2F5,C2F3,1-C3F7, 2-C3F7, and C3F5 from 300 K to 900 K. Both the magnitude and the temperature dependences of rate coefficients as well as product branching between associative and dissociative attachment are highly system specific; however, thermal attachment to all species is inefficient, never exceeding 5% of the collision rate. The data are analyzed using a recently developed kinetic modeling approach, which uses extended Vogt-Wannier theory as a starting point, accounts for dynamic effects such as coupling between the electron and nuclear motions through empirically validated functional forms, and finally uses statistical theory to determine the fate of

  4. Hepatite aguda colestática pelo propiltiouracil: relato de caso Acute cholestatic hepatitis induced by propylthiouracil: case report

    Mônica Beatriz PAROLIN; Lopes, Reginaldo Werneck; José Ederaldo Queiroz TELLES; Ioshii, Sergio Ossamu, 1960-; Nemer HAJAR

    2000-01-01

    Propiltiouracil é uma droga amplamente utilizada no tratamento do hipertiroidismo. A hepatotoxicidade é um dos efeitos colaterais mais raros e também mais graves associados a ela. Relata-se um caso de hepatite aguda colestática que acomete um jovem de 15 anos em uso de propiltiouracil para tratamento de hipertiroidismo. Causas virais, metabólicas e autoimunes foram excluídas e a biopsia hepática revelou achados histopatológicos sugestivos de hepatite colestática induzida por droga. Com a susp...

  5. Consenso intersociedades para el manejo de infecciones respiratorias: bronquitis aguda y enfermedad pulmonar obstructiva crónica

    Gustavo Lopardo; Claudia Pensotti; Pablo Scapellato; Oscar Caberlotto; Aníbal Calmaggi; Liliana Clara; Manuel Klein; Gabriel Levy Hara; María J. López Furst; Analía Mykietiuk; Daniel Pryluka; Maria J. Rial; Claudia Vujacich; Diego Yahni

    2013-01-01

    La Sociedad Argentina de Infectología convocó a otras sociedades científicas para elaborar una guía práctica y actualizada para el manejo del tratamiento antibiótico de las bronquitis agudas (BA) y los episodios de reagudización de enfermedad pulmonar obstructiva crónica (EPOC), con el objetivo de promover el uso racional de los recursos diagnósticos y terapéuticos. La BA se caracteriza por la inflamación del árbol bronquial que afecta tanto a adultos como a niños sin enfermedades pulmonares ...

  6. Adiponectina sérica e risco cardiometabólico em pacientes com síndromes coronarianas agudas

    Gustavo Bernardes de Figueiredo Oliveira; João Ítalo Dias França; Leopoldo Soares Piegas

    2013-01-01

    FUNDAMENTO: O tecido adiposo representa não somente uma fonte de energia estocável, mas principalmente um órgão endócrino que secreta várias citoquinas. A adiponectina, uma nova proteína semelhante ao colágeno, foi descoberta como uma citoquina específica do adipócito e um promissor marcador de risco cardiovascular. OBJETIVO: Avaliar a associação entre os níveis séricos da adiponectina e o risco para a ocorrência de eventos cardiovasculares, em pacientes com síndromes coronarianas agudas (SCA...

  7. Ensayo de toxicidad aguda oral de un fitofármaco obtenido a partir del pseudotallo de Musa paradisiaca L.

    Guevara Orellanes, Irania; Rodriguez Torres, Caridad C.; Pérez Capote, María Regla; León Fernández, Olga Sonia; Rodriguez, Susana Sam; Álvarez, Dalia; Castañeda, Juana; Vega, Jorge Luis

    2003-01-01

    El fitofármaco elaborado a partir del extracto de pseudotallo de Musa paradisiaca es un producto natural que presenta además en su composición miel de abejas (edulcorante) y propóleos (preservante). Entre los requisitos para el registro de medicamentos se encuentran los ensayos toxicológicos, los cuales garantizan un margen de seguridad para el empleo de los productos que son evaluados, según las normativas establecidas por la OECD. Para el estudio de toxicidad aguda oral se emplearon rata...

  8. Custo-efetividade de fondaparinux em pacientes com Síndrome Coronariana Aguda sem supradesnivelamento do ST

    Camila Pepe; Márcio Machado; Alexandre Olimpio; Rui Ramos

    2012-01-01

    FUNDAMENTO: O uso combinado de agentes antitrombínicos, antiplaquetários e estratégias invasivas na síndrome coronariana aguda sem supradesnivelamento do ST (SCAsSST) reduz eventos cardiovasculares. O fondaparinux demonstrou equivalência à enoxaparina na redução de eventos cardiovasculares, porém com menor índice de sangramento nos pacientes que usaram fondaparinux. OBJETIVO: Avaliar o custo-efetividade de fondaparinux versus enoxaparina em pacientes com SCAsSST no Brasil a partir da perspect...

  9. Intoxicaciones agudas en un Servicio de Urgencias. Estudio descriptivo en el Área Sanitaria III de Asturias

    D González-Fernández

    2009-01-01

    Full Text Available En los últimos años ha aumentado el número de intoxicaciones agudas en nuestro país, constituyen el 1-2% de las atenciones en los servicios de urgencias. El objetivo de este estudio es conocer la incidencia de las intoxicaciones agudas atendidas en el Servicio de Urgencias del Hospital San Agustín, sus principales características clínicas y sociodemográficas. Para ello, se ha realizado un estudio retrospectivo de las intoxicaciones agudas atendidas, durante el año 2007, en el Servicio de Urgencias del Hospital San Agustín. Se realizó un análisis descriptivo de las variables clínicas y sociodemográficas incluidas en el protocolo. Se atendieron 515 casos (1,06% de las urgencias atendidas con una incidencia de 333 casos/105hab/año. La edad media de los pacientes fue de 42 años (±15 D.E. siendo un 66,8% varones. El 53,1% de las intoxicaciones se atendieron en fin de semana y el 50,4%se atendieron en el tramo horario entre las 22 y las 8 horas. En función de la intencionalidad: 73,2% Ingesta voluntaria de alcohol y drogas. 22,1 % Intentos de suicidio. 4,7% Intoxicaciones accidentales. Los tóxicos más utilizados fueron: el etanol (75%, en segundo lugar las benzodiacepinas (29,5% y en tercer lugar lacocaína (5,2%. Destino: Alta 42%, Box observación 51%, Ingreso en planta 5%, Ingreso en UCI: 2%. Solo falleció un paciente (0,19%. En conclusión, las intoxicaciones agudas son más frecuentes en varones y su incidencia aumenta durante el fin de semana y la noche. Lostóxicos mas empleados son el alcohol y las benzodiacepinas. La mayoría de las intoxicaciones fueron resueltas en el Servicio de Urgencias.

  10. Mecanismos del daño celular en la insuficiencia renal aguda Mechanisms of cell damage in acute renal failure

    José Martínez

    1989-01-01

    Los mecanismos del da no celular en la insuficiencia renal aguda Incluyen alteraciones en la producción de energía, la permeabilidad celular y el transporte de calcio. Dichas alteraciones producen cambios progresivos en la estructura celular que pueden ser reversibles si desaparece la causa que llevó a la falla renal, excepto cuando se alcanza la fase final de la lesión de la membrana y se llega a necrosis celu...

  11. Estrategia de atención de niños hospitalizados por infecciones respiratorias agudas bajas

    Ana M Ferrari; María C Pirez; Alicia Ferreira; Ivonne Rubio; Alicia Montano; Rosa Lojo; Graciela Palomino; Gustavo Giachetto; Alvaro Galiana; María J Sarachaga; Silvana Mercado; Osvaldo Martinez; Marta Alberti; Hector Chiparelli; Soledad Mateos

    2002-01-01

    OBJETIVO: Mejorar la calidad de la atención hospitalaria de los niños con infecciones respiratorias agudas bajas, aumentar los conocimientos sobre esa patología y mejorar la eficiencia en el uso de los recursos asistenciales, por medio de una estrategia que se denominó Plan de Invierno.MÉTODOS: La estrategia se basó en la utilización de protocolos de diagnóstico y tratamiento, internación por cuidados progresivos y por enfermedad, adecuación de los recursos asistenciales y creación de un sist...

  12. Insuficiência renal aguda em pacientes internados por insuficiência cardíaca descompensada - Reincade

    Larissa Cristina Nascimento de Barros; Fábio Serra Silveira; Marcos Serra Silveira; Thamara Carvalho Morais; Marco Antônio Prado Nunes; Kleyton de Andrade Bastos

    2012-01-01

    INTRODUÇÃO: Insuficiência renal aguda (IRA) acontece com frequência em pacientes críticos, porém a significância clínica de sua ocorrência não tem sido determinada na insuficiência cardíaca descompensada (ICD). OBJETIVOS: Estudar a ocorrência e valor prognóstico da IRA em pacientes internados por ICD e avaliar comparativamente com aqueles sem a complicação o perfil clínico-laboratorial e a mortalidade intra-hospitalar. MÉTODOS: Estudo prospectivo em 85 pacientes internados em terapia intensiv...

  13. Lesão pulmonar aguda associada à transfusão Transfusion-related acute lung injury

    Antonio Fabron Junior; Larissa Barbosa Lopes; José Orlando Bordin

    2007-01-01

    Lesão pulmonar aguda associada à transfusão (transfusion-related acute lung injury, TRALI) é uma complicação clínica grave relacionada à transfusão de hemocomponentes que contêm plasma. Recentemente, TRALI foi considerada a principal causa de morte associada à transfusão nos Estados Unidos e Reino Unido. É manifestada tipicamente por dispnéia, hipoxemia, hipotensão, febre e edema pulmonar não cardiogênico, que ocorre durante ou dentro de 6 h, após completada a transfusão. Embora o exato mecan...

  14. Intoxicaciones agudas por psicofármacos y drogas de abuso en Pontevedra durante el año 2001

    Fernández, P.; R. Sertal; A.M. Bermejo; M.J. Tabernero

    2005-01-01

    Se presenta un estudio epidemiológico de las intoxicaciones agudas por psicofármacos y drogas de abuso (excluyendo el alcohol), atendidas en el Servicio de Urgencias de adultos del Complejo Hospitalario de Pontevedra (CHOP) durante el año 2001. Utilizando el test cualitativo de screening de drogas de abuso Triage TM8 (Biosite Diagnostics), se analizaron 554 orinas, de las cuales 318 resultaron positivas, lo que supone un 0,56% del total de urgencias atendidas en este Cent...

  15. Intoxicaciones agudas en Santiago de Compostela,en un período de cuatro años

    Fernández, P.; M. Ortega; A.M. Bermejo; M.J. Tabernero; M. López Rivadulla; ME Concheiro

    2003-01-01

    El objetivo de este trabajo fue evaluar las caracterís-ticas de un grupo de pacientes intoxicados en el área sanitaria deSantiago de Compostela. Para ello, se estudiaron 1192 intoxica-ciones agudas atendidas en el Servicio de Urgencias y Unidadde Cuidados Intensivos del Hospital Clínico Universitario deesta ciudad, desde el 1 de enero de 1993 al 31 de diciembre de1996. Se han considerado solo aquellos casos en los que se soli-citó un análisis toxicológico a este Instituto de Medicina Legal,de...

  16. Nefrotoxicidad glomerular tardía en niños con leucemia aguda linfoblástica

    Fraga Rodriguez, Gloria Mª

    2015-01-01

    Introducción En el tratamiento de la leucemia aguda linfoblástica (LAL) infantil se utilizan habitualmente altas dosis de methotrexate (MTX), entre otros quimioterápicos. Este tratamiento puede ocasionar un deterioro transitorio de la función renal que es bien conocido, si bien los posibles cambios a largo plazo no están muy descritos. El objetivo general de este estudio es evaluar la posible toxicidad glomerular tardía de dos protocolos de tratamiento de LAL de la Sociedad Española de ...

  17. Impacto de las alteraciones moleculares en el pronóstico de la Leucemia Mieloide Aguda (LMA) "de novo"

    Hoyos Colell, Montserrat

    2014-01-01

    [spa] La Leucemia Mieloide Aguda (LMA) es una enfermedad hematológica heterogénea, que se caracteriza por la acumulación de células inmaduras en médula ósea. Los pacientes diagnosticados de LMA tienen una supervivencia del 40%, aproximadamente. Existen factores que predicen el pronóstico de los pacientes, como la edad, la leucocitosis, las comorbilidades, la enfermedad residual mínima y la citogenética. Además y gracias a la aparición de las nuevas técnicas moleculares se han descrito un elev...

  18. Etnografía de la infección respiratoria aguda en una zona rural del altiplano mexicano

    MARTÍNEZ HOMERO; SURIANO KIMBERLY; RYAN GERY W.; PELTO GRETEL H.

    1997-01-01

    Objetivo. Identificar los términos utilizados por las madres para referirse a enfermedades, signos y síntomas relacionados con infecciones respiratorias agudas, así como los signos de alarma que las motivan a buscar atención médica; asimismo, describir prácticas comunes de manejo de la enfermedad en el hogar. Material y métodos. Se trata de un estudio etnográfico en seis comunidades rurales del altiplano mexicano. Se entrevistó a 12 informantes clave, a seis madres de niños fallecidos por inf...

  19. Oclusão arterial aguda de stent fêmoro-poplíteo Acute femoropopliteal artery stent obstruction

    Fabio Henrique Rossi; Milton Kiyonory Uehara; Juliana Chen; Thiago Emilio Burza Maia; Eduardo Mulinari Darold; Andréia Silveira Martins; Akash Kuzhiparambil Prakasan; Nilo Mitsuro Izukawa

    2009-01-01

    A oclusão aguda de stent fêmoro-poplíteo pode ser causa de isquemia crítica dos membros inferiores. A terapia fibrinolítica pode não ser a forma de tratamento mais indicada para o grupo de pacientes com esse quadro clínico. Neste artigo, apresentamos um caso em que a retirada de um fragmento de stent por endarterectomia tornou possível a revascularização do membro.Femoropopliteal stent obstruction may be responsible for acute lower limb ischemia. Fibrinolytic treatment may not be the best the...

  20. Tratamiento quirúrgico de la diverticulitis aguda en la Comunidad Valenciana. Estudio multicéntrico.

    Salvador Martínez, Antonio

    2015-01-01

    Diverticulitis aguda. Estado actual y controversias Este término representa un espectro de los cambios inflamatorios que van desde una inflamación local subclínica hasta la peritonitis generalizada con perforación libre. Su mecanismo de aparición gira alrededor de una perforación de un divertículo. El antiguo concepto de obstrucción luminal probablemente represente un hecho raro. El aumento de la presión intraluminal o las partículas espesadas de alimentos pueden erosionar la pared d...

  1. Infección respiratoria aguda en niños que acuden a un centro de desarrollo infantil

    Nandí-Lozano Eugenia

    2002-01-01

    Full Text Available Objetivo. Establecer la incidencia de infección respiratoria y los patrones de colonización faríngea en niños que asisten a guarderías. Material y métodos. Se realizó un estudio de cohorte en niños menores de cuatro años de edad, de uno u otro sexo, asistentes a la guardería del Hospital Infantil de México Federico Gómez, de la Ciudad de México, durante abril a octubre de 1999. Se registró la presencia de infección de vías aéreas superiores cada semana, y de colonización cada tres meses, mediante un exudado nasofaríngeo. Se hizo estadística descriptiva de las variables analizadas. Se determinaron tasas de infección respiratoria aguda. Resultados. Se estudiaron 85 niños, 40 del sexo femenino (47% y 45 del sexo masculino (53% durante un total de 9 090 niños/día de seguimiento. Tres niños tenían antecedentes de atopia (3.52%, seis niños antecedentes de asma (7.05%, y 39 eran expuestos a tabaquismo pasivo (45.88%. Se diagnosticaron 246 rinofaringitis (95.3%, nueve otitis media aguda (3.48%, tres bronquiolitis (1.16%, para un total de 258 eventos de infección respiratoria aguda. La tasa de incidencia global fue de 10.35 infecciones por niño/año de observación (IC 95% 8.7-12.0. La incidencia de otitis y bronquiolitis fue de 0.36 y 0.12 eventos por niño/año de observación. Se tomaron cultivos nasofaríngeos con una prevalencia de colonización para S. pneumoniae de 20.4%, H. influenzae no tipificable 13.1% y Moraxella catarrhalis 8.1%. Conclusiones. Los resultados no sólo demuestran una alta prevalencia de colonización debido a cepas invasivas, sino que también revelan una tasa de incidencia de infección respiratoria aguda del doble de lo reportado en estudios de comunidad. Estos resultados ayudan a caracterizar un problema pobremente documentado en nuestro país.

  2. Abscesso subperiosteal com extensão epidural devido à rinossinusite aguda em criança de dez anos

    Epaminondas de Souza Mendes Junior

    2016-04-01

    Full Text Available RESUMO A rinossinusite aguda é uma das afecções mais prevalentes das vias aéreas superiores. Fatores anatômicos presentes em crianças e jovens propiciam o aparecimento de complicações orbitárias. Embora mais raras, as complicações intracranianas das rinossinusites perfazem um grau alto de letalidade, são mais comuns em pacientes acima de sete anos, e devem ser tratadas por uma equipe multidisciplinar.

  3. Radical carbonylations using a continuous microflow system

    Takahide Fukuyama

    2009-07-01

    Full Text Available Radical-based carbonylation reactions of alkyl halides were conducted in a microflow reactor under pressurized carbon monoxide gas. Good to excellent yields of carbonylated products were obtained via radical formylation, carbonylative cyclization and three-component coupling reactions, using tributyltin hydride or TTMSS as a radical mediator.

  4. EPR spin trapping of protein radicals

    Davies, Michael Jonathan; Hawkins, Clare L

    2004-01-01

    Electron paramagnetic resonance (EPR) spin trapping was originally developed to aid the detection of low-molecular-mass radicals formed in chemical systems. It has subsequently found widespread use in biology and medicine for the direct detection of radical species formed during oxidative stress...... selected examples of radical formation on proteins....

  5. Free radicals and Dupuytren's contracture.

    Murrell, G. A.; Francis, M. J.; Bromley, L.

    1987-01-01

    The concentration of substrate expressed as hypoxanthine capable of reacting with xanthine oxidase to release superoxide free radicals (O2-) was measured in control and Dupuytren's contracture palmar fascia. In Dupuytren's contracture palmar fascia the concentration of hypoxanthine was six times that of control and was greatest in "nodular" areas. Xanthine oxidase activity was also detected in Dupuytren's contracture palmar fascia. These results suggest a greater potential for hypoxanthine-xa...

  6. Doença de Chagas aguda pós-transfusional sem miocardite

    Evanil Pires de Campos

    1988-12-01

    Full Text Available Trata-se de paciente do sexo feminino, com 59 anos de idade, procedente de Itaporanga (SP, diabética e nefropata crônica, internada em virtude de surtos de pielonefnte e insuficiência renal aguda. Dentre outras medidas terapêuticas, recebeu transfusão de sangue. Cerca de dois dias após a última transfusão (sangue oriundo de doador, posteriormente identificado como chagásico encontraram-se formas tripomastigotas de Trypanosoma cruzi em lâmina preparada para execução de hemograma. Iniciou-se tratamento com Benzonidazol. A paciente cursou para, pleuropneumonia e de secreção purulenta cirúrgica isolou-se Klebsiella spp. A septicemia conduziu a paciente ao êxito letal. Nenhuma lesão tecidual foi observada no miocárdio, no sistema nervoso central, adrenal ou nos demais órgãos examinados.D.E. O., a 59 years old white female bom in Paranagua (PR, came from Itaporanga with Kimmelstiel Wilson nephropathy diabetes and pyelonephritis with acute renal failure followed by a nephrectomy. Anaemia and malnutrition led to blood transfusions before and after surgery. On the 34th day, she developed high fever, prostration, agressivity with mental confusion, abdominal cramps and diarrhea. Trypanosomes were seen in peripheral blood smears. Haemoculture and xenodiagnosis was positive. A complement fixation test was negative. Benznidazole (6 mg/kg/day was started. During treatment she presented pulmonary infection and a surgical purulent secretion showed Klebsiella sp. Despite intensive medical care she died of sepsis. Autopsy revealed evidence of diabetes mellitus (glomerulosclerosis, hepatic lesions, pancreatic fibrosis and generalised arteriolar disease. No chagasic lesions were detected in the heart, central nervous system, adrenal or other tissues.

  7. Esofagitis necrotizante aguda: Una patología poco conocida Acute esophageal necrosis: An underdiagnosed disease

    L. Julián Gómez

    2008-11-01

    Full Text Available La esofagitis necrotizante aguda (ENA es una rara entidad cuya etiología es desconocida, siendo el mecanismo patogénico multifactorial, participando fundamentalmente el compromiso isquémico, la malnutrición y la obstrucción del tracto digestivo alto. Los hallazgos endoscópicos muestran una coloración negruzca de la mucosa esofágica con transición brusca a nivel de la unión esofagogástrica. El pronóstico depende de las enfermedades de base. Se revisan los casos de ENA, excluyendo los secundarios a caústicos, recogidos de forma retrospectiva durante los últimos 2 años. Se analizan los factores de riesgo, la presentación clínica, los hallazgos endoscópicos, la histología, el tratamiento y la evolución. En nuestro departamento, se han diagnosticado 7 casos de ENA en 6.003 gastroscopias realizadas en el periodo de estudio, representando así la ENA el 0,11% de la exploraciones.Acute esophageal necrosis is a rare disorder, and its etiology is unknown, the mechanism of damage being usually multifactorial and secondary to ischemic compromise, acute gastric outlet obstruction, and malnutrition. Endoscopic findings show circumferential black discoloration of the distal esophagus with proximal extension ending sharply at the gastroesophageal junction, which is the most common presentation. Prognosis depends on comorbid illnesses. In this study we analyze all cases reported in a retrospective analysis over a 2-year period to define risk factors, clinical presentation, endoscopic features, histological appearance, treatment and outcome. Our department has recorded 7 cases from 6,003 endoscopies performed in the last 2 years. The finding of a "black esophagus" represented 0.11% of cases.

  8. INSUFICIENCIA RENAL AGUDA EN EL ANCIANO. CONSIDERACIONES ACERCA DE SU VALORACIÓN Y TRATAMIENTO.

    Musso CG

    2005-02-01

    Full Text Available RESUMEN:La insuficiencia renal aguda (IRA es un trastorno frecuente en los ancianos a raíz de la senescencia renal, la menor metabolización de los fármacos y la mayor exposición a la polifarmacia y enfermedades sistémicas que ellos padecen. Las siguientes son las principales características de la IRA en el anciano: carácter multifactorial, presentación clínica atípica, fragilidad tubular, patrón de síndrome intermedio y poca fiabilidad del examen físico y de los índices urinarios en la interpretación de su etiología. Las medidas de profilaxis y rehidratación siguen siendo los mejores tratamientos de la IRA en el viejo. La biopsia renal y la diálisis tienen el mismo rol tanto en el grupo senil como en el joven.ABSTRACTACUTE RENAL FAILURE IN THE ELDERLY: PEARLS FOR ITS ASSESSMENT AND TREATMENT.Acute renal failure (ARF is a frequent disorder in the elderly, and this phenomenon is due to the senescence process, reduced metabolization of drugs, increased exposure to polypharmacy and systemic diseases of the aged group. The following are the main characteristics of the ARF in the elderly: mulfactorial, atypical presentation, tubular frailty, intermediate syndrome pattern, low reliable physical examination and urinary indeces. Profilaxis and rehydration are the best treatments for ARF in the old population. Renal biopsy and dialysis have the same role in young and old people.

  9. Citarabina y reacciones cutáneas en leucemia aguda mieloide

    Sofía Grille

    2013-12-01

    Full Text Available La citarabina es un antimetabolito utilizado en el tratamiento de las leucemias agudas mieloides (LAM. Esta droga presenta numerosos efectos adversos (mielosupresión, toxicidad en sistema nervioso central, hepática, gastrointestinal, ocular y cutánea. La toxicidad dermatológica es habitualmente descrita como rara, sin embargo existen diferencias en la incidencia comunicada. Se realizó un estudio retrospectivo donde se incluyeron todas las LAM tratadas con quimioterapia que incluía citarabina, entre el 1º de julio 2006 y el 1° de julio 2012. Se incluyeron 46 pacientes con una mediana de edad de 55 años. La incidencia global de reacciones cutáneas fue de 39% (n = 18. La presencia de lesiones cutáneas no se asoció con sexo, edad, antecedentes de atopía, de reacciones medicamentosas, tipo de LAM ni dosis de citarabina utilizada. Las lesiones se observaron entre 2 a 8 días de iniciado el tratamiento. En cuanto al grado lesional, 27.8% presentaron grado 1, 38.9% grado 2 y 33.3% grado 3. No existieron lesiones grado 4 ni muerte vinculada a toxicidad cutánea. En cuanto al tipo de lesiones, 55.6% se presentaban con máculas, 22.2% con pápulas y 22.2% con eritema. Con respecto a la distribución de las lesiones, 52% de los pacientes presentaron una distribución difusa, 39.3% acral y 8.7% a nivel flexural. Las reacciones adversas cutáneas con la administración de citarabina son frecuentes en nuestro medio, en algunos casos con afectación grave. Si bien suelen resolverse espontáneamente, pueden determinar mayor riesgo de infección, así como comprometer la calidad de vida.

  10. Injúria renal aguda: um alerta global Acute kidney injury: a global alert

    Philip Kam Tao Li

    2013-03-01

    Full Text Available A Injúria Renal Aguda (IRA é cada vez mais prevalente nos países desenvolvidos e nos em desenvolvimento, e está associada com morbidade e mortalidade severas. A maioria das causas da IRA pode ser evitada por meio de intervenções em nível individual, comunitário, regional e intra-hospitalar. Medidas efetivas devem incluir, em toda a comunidade, os esforços para aumentar a consciência dos efeitos devastadores do IRA e fornecer orientações sobre as estratégias de prevenção, bem como o reconhecimento e tratamento precoces. Os esforços devem ser focados em minimizar as causas de IRA, aumentando a consciência da importância de medidas seriadas de creatinina sérica em pacientes de alto risco para IRA, e documentar o volume de urina em pessoas gravemente doentes para obtenção de diagnóstico precoce; até o momento, não há ainda um papel definitivo para outros biomarcadores. Há a necessidade de protocolos para sistematizar a conduta em condições de IRA pré-renal e em infecções específicas. Dados mais precisos sobre a verdadeira incidência e o impacto clínico da IRA ajudarão a melhor conhecer a importância desta doença, a aumentar o conhecimento de IRA por parte dos governantes, dos médicos em geral e de outros profissionais de saúde para ajudar na prevenção da doença. A prevenção é a chave para evitar a pesado ônus de mortalidade e morbidade associada com IRA.

  11. Experimental model of severe acute pancreatitis in rabbits Modelo experimental de pancreatite aguda grave em coelhos

    Alberto Goldenberg

    2007-10-01

    Full Text Available PURPOSE: To develop an experimental model of severe acute pancreatitis in rabbits through a pancreatic ductal injection of sodium taurocholate. METHODS: Twenty-four albino rabbits of the New Zealand lineage were distributed into four groups of six animals (A, B, C and S. The rabbits of three experimental groups (A, B and C were submitted to a laparatomy and received a pancreatic ductal injection of 1ml/kg sodium taurocholate 5%. Also, they were submitted to further laparatomies after 4h, 8h and 12h, respectively. The control group (S was subdivided into two groups of three animals: in subgroup S1 only the pancreatic duct catheterization was performed whereas in subgroup S2 the pancreatic duct catheterization as well as an injection of 1ml/kg physiologic solution 0.9% were carried out. After 12 hours, the rabbits were evaluated. In the re-intervention, blood was collected to determine the amylasemia and a pancreatectomy was carried out to investigate interstitial infiltration, steatonecrosis and necrosis of the organ, using an optical microscope. RESULTS: There was an elevation of amylase in all groups thus proving the existence of acute pancreatitis. The size of the interlobular septum increased progressively with a greater variation between group S1 (0.13 and group C (0. 53 (p=0.035. While all the animals in group A exhibited focal cellular necrosis, it was more intense in the rabbits of group B and culminated with a high proportion of severe pancreatic necrosis in group C animals. The difference in the intensity of cellular necrosis showed statistic significance (p=0.001. CONCLUSION: The proposed experimental model demonstrated its reproducibility and effectiveness in producing severe acute pancreatitis in rabbits.OBJETIVO: Desenvolver modelo experimental de pancreatite aguda grave em coelhos por meio da injeção de taurocolato de sódio no ducto pancreático. MÉTODOS: Vinte e quatro coelhos albinos da linhagem Nova Zelândia foram distribu

  12. Chemical repair of trypsin-histidinyl radical

    Oxyl radicals, such as hydroxyl, alkoxyl and peroxyl, react with biomolecules to produce bioradicals. Unless chemically repaired by suitable antioxidants, these bioradicals form stable products. This leads to loss of biological function of parent biomolecules with deleterious biological results, such as mutagenesis and cancer. Consequently, the understanding of the mechanisms of oxyl radical damage to biomolecules and chemical repair of such damage is crucial for the development of strategies for anticarcinogenesis and radioprotection. In this study the chemical repair of the histidinyl radical generated upon the trichloromethylperoxyl radical reaction with trypsin vas investigated by gamma radiolysis. The trypsin histidinyl radical is a resonance-stabilized heterocyclic free radical which was found to be unreactive with oxygen. The efficacy of the chemical repair of the trypsin-histidinyl radical by endogenous antioxidants which are electron donors (e.g. 5-hydroxytryptophan, uric acid) is compared to that of antioxidants which are H-atom donors (e. g. glutathione). 9 refs., 2 figs., 1 tab

  13. Abordaje transumbilical en pacientes pediátricos con sospecha de apendicitis aguda. Un serie de 424 pacientes

    Luis Augusto Zárate Suárez

    2013-05-01

    Full Text Available Antecedentes: El tratamiento de la apendicitis aguda implica su extirpación; es frecuente la solicitud de cicatrices postquirúrgicas del mejor tamaño posible. Una de las estrategias disponibles es el abordaje transumbilical. Objetivos: Descubrir las características clínicas y los desenlaces operatorios de los pacientes pediátricos en quienes se realiza apendicectomía vía transumbilical. Metodología: Estudio prospectivo de 424 pacientes sucesivos en cuanto a los desenlaces operatorios a corto plazo. Resultados: El tiempo promedio de intervención quirúrgica fue de 22 minutos; 95,8% de los pacientes presentó evolución satisfactoria del postquirúrgico; 1,4% de los pacientes se reintervino para drenar un absceso intracavitario residual y 0,2% presentó infencción de sitio operatorio sin mas complicaciones. Conclusión: El abordaje transumbilical de la apendicitis es una alternativa minimamente invasiva para todos los estados de apendicitis aguda e implica disminución del tiempo de realización, menor estancia del postquirúrgico, menor incidencia de complicaciones y mayor conformidad con los resultados estéticos.

  14. Meningencefalites bacterianas agudas em crianças: complicações e sequelas neurológicas

    NATALINO WLADIMIR

    1999-01-01

    Full Text Available Foram estudadas 271 crianças com idade inferior a 15 anos, com diagnóstico de meningencefalite bacteriana aguda (MBA, no período 1980 -- 1990. Os pacientes foram divididos em dois grupos, conforme não tivessem recebido tratamento prévio (STP, 153 casos, e os que receberam tratamento prévio (CTP, 118 casos. Ocorreram diferenças significativas em relação a identificação do agente etiológico, que foi maior no grupo STP, e em relação a ocorrência de ventriculite, maior no grupo CTP. Ocorreu óbito em 19,5% dos 271 casos, com predomínio em crianças de idade abaixo de 12 meses (29,7% e nos pacientes com MBA por Streptococcus pneumoniae. As manifestações epilépticas e as paresias na fase aguda da MBA predominaram em crianças de idade abaixo de 1 ano. Foram identificados e tratados do ponto de vista neurocirúrgico as ventriculites, higroma subdural, hidrocefalia, empiema subdural e abscesso cerebral.

  15. Efecto de los hits de un cribado HTS en la estructura y función de mutantes de nucleofosmina asociados a leucemia mieloide aguda

    Sendino Mouliet, Maria

    2015-01-01

    Validación térmica de un compuesto estabilizador de nucleofosmina seleccionado en un estudio HTS y análisis de dicho compuesto en células HeLa portadoras de la mutación que más comunmente causa la leucemia mieloide aguda.

  16. Aportación del análisis inmunofenotípico en la caracterización de la leucemia aguda y en la identificación de subgrupos moleculares

    Muñoz Marín, Luz

    2006-01-01

    Consultable des del TDX Títol obtingut de la portada digitalitzada La leucemia aguda es una alterción clonal de los progenitores hematopoyéticos, con una gran heterogeneidad tando desde el punto de vista clínico como biológico. Actualmente el tratamiento de los pacientes con leucemia aguda se estratifica según factores pronósticos. Disponemos de diversas técnicas útiles en el diagnóstico, clasificación y seguimiento de los enfermos con leucemia aguda y es necesario integrar todas ellas ...

  17. Iron and iron derived radicals

    We have discussed some reactions of iron and iron-derived oxygen radicals that may be important in the production or treatment of tissue injury. Our conclusions challenge, to some extent, the usual lines of thought in this field of research. Insofar as they are born out by subsequent developments, the lessons they teach are two: Think fast! Think small! In other words, think of the many fast reactions that can rapidly alter the production and fate of highly reactive intermediates, and when considering the impact of competitive reactions on such species, think how they affect the microenvironment (on the molecular scale) ''seen'' by each reactive molecule. 21 refs., 3 figs., 1 tab

  18. Aromatic-radical oxidation chemistry

    Glassman, I.; Brezinsky, K. [Princeton Univ., NJ (United States)

    1993-12-01

    The research effort has focussed on discovering an explanation for the anomalously high CO{sub 2} concentrations observed early in the reaction sequence of the oxidation of cyclopentadiene. To explain this observation, a number of plausible mechanisms have been developed which now await experimental verification. One experimental technique for verifying mechanisms is to probe the reacting system by perturbing the radical concentrations. Two forms of chemical perturbation of the oxidation of cyclopentadiene were begun during this past year--the addition of NO{sub 2} and CO to the reacting mixture.

  19. Laser spectroscopy of hydrocarbon radicals

    Chen, P. [Harvard Univ., Cambridge, MA (United States)

    1993-12-01

    The author reports the application of supersonic jet flash pyrolysis to the specific preparation of a range of organic radicals, biradicals, and carbenes in a skimmed molecular beam. Each species was produced cleanly and specifically, with little or no secondary reactions by the thermal dissociation of appropriately designed and synthesized organic precursors. Photoelectron spectra of the three isomeric C{sub 3}H{sub 2} carbenes, ortho-benzyne, and the {alpha},3-dehydrotoluene biradical, were used to establish adiabatic ionization potentials for use in thermochemical determinations.

  20. Detection of a secondary muoniated radical

    McCollum, Brett M.; Brodovitch, Jean-Claude [TRIUMF and Department of Chemistry, Simon Fraser University, Burnaby, BC, V5A 1S6 (Canada); Clyburne, Jason A.C. [Department of Chemistry, Saint Mary' s University, Halifax, NS, B3H 3C3 (Canada); Percival, Paul W., E-mail: percival@sfu.c [TRIUMF and Department of Chemistry, Simon Fraser University, Burnaby, BC, V5A 1S6 (Canada); West, Robert [Organosilicon Research Center, University of Wisconsin, Madison, WI 53706 (United States)

    2009-04-15

    Muoniated free radicals are formed by addition of muonium to unsaturated molecules. Successful detection by transverse-field muon spin rotation (muSR) usually requires pure or highly concentrated samples and a muonium reaction rate in excess of 10{sup 9} M{sup -1}s{sup -1} to ensure that the muon spin polarization is coherently transferred to the radical. For this reason muoniated radicals reported to date are all the primary radical products of Mu reaction. Thus, it was expected that Mu addition to a silylene would result in detection of a silyl radical. However, the muon hyperfine constant determined by experiment is much smaller than the value predicted by density functional calculations. Instead, it is consistent with a disilanyl radical, the secondary radical formed by reaction of the initially formed silyl radical with a second silylene molecule. From an analysis of the signal amplitude it was deduced that the second-order rate constant for reaction of the muoniated silyl radical with the parent silylene is 5.7x10{sup 8} M{sup -1}s{sup -1}. This work represents the first example of direct detection of a secondary radical product by transverse-field muSR.

  1. Doenças respiratórias agudas em serviços de saúde entre 1996 e 2001, Fortaleza, CE

    Façanha Mônica Cardoso

    2004-01-01

    Full Text Available OBJETIVO: As doenças respiratórias agudas, principalmente as pneumonias, são a causa mais importante de óbito em menores de cinco anos e são responsáveis por doença grave nos maiores de 60 anos. O estudo realizado tem como objetivo descrever as principais características epidemiológicas dos casos de doenças respiratórias agudas notificadas pelas unidades de saúde. MÉTODOS: Todos os registros de atendimentos de pacientes com doença respiratória aguda, no período entre 1996 e 2001, foram revistos semanalmente, em formulário específico, a partir dos boletins de atendimento médico preenchidos por 100 unidades públicas de saúde. Os dados foram classificados em não pneumonia e pneumonia por faixa etária. RESULTADOS: Foram informados 2.050.845 casos de doença respiratória aguda no período estudado. Os meses com maior número de casos foram maio e junho. A faixa etária mais acometida foi a de um a quatro anos, com cerca do dobro do número de casos das outras faixas etárias. Pneumonias representaram, aproximadamente, 7,7% dos casos. CONCLUSÕES: O acompanhamento das doenças respiratórias agudas serve para mostrar sua magnitude em termos numéricos, e estimular seu diagnóstico apropriado, tratamento precoce e prevenção, tanto das complicações, quanto de sua ocorrência.

  2. Bronquiolite aguda, uma revisão atualizada Acute bronchiolitis, an updated review

    Werther Brunow de Carvalho

    2007-04-01

    Full Text Available A bronquiolite aguda (BA é um diagnóstico freqüente de internação hospitalar em pediatria, ocasionada principalmente pelo vírus sincicial respiratório (VSR. Ocorre epidemicamente nos meses de outono e inverno. Algumas populações de crianças (recém-nascidos pré-termo, cardiopatia congênita, doença pulmonar crônica, imunocomprometidos, desnutridos, entre outros apresentam maior risco de morbidade e mortalidade. Os vírus multiplicam-se nas células epiteliais ciliadas, e a inflamação e os debris celulares ocasionam obstrução da via aérea, hiperinsuflação, atelectasia localizada, chiado e alterações das trocas gasosas. Não existem evidências definitivas em relação aos tratamentos utilizados para esta doença. O tratamento inclui a utilização de oxigênio, hidratação, beta-2 agonistas por via inalatória, epinefrina racêmica, DNase recombinante, fisioterapia respiratória, entre outros. Medidas profiláticas: administração de anticorpos monoclonais (palivizumab. A maioria das crianças com BA, independentemente da gravidade da doença, recuperam-se sem seqüelas. O curso natural desta doença, habitualmente, varia entre sete a dez dias, mas algumas crianças permanecem doentes por semanas.Acute bronchiolitis (AB is a frequent cause of hospitalization among children and its main etiological agent is respiratory syncytial virus (RSV. It occurs epidemically during autumn and winter. Some populations of children such as premature newborns, infants with congenital heart disease and those with chronic lung disease, immunocompromised, undernourished, among others, present increased morbidity and mortality risk. The virus multiplies in epithelial ciliated cells while inflammation and cellular debris cause obstruction of the airways, hyperinflation, atelectasis, and wheezing and gas exchange imbalance. Definitive evidence still does not exist about treatment of this disease, Treatment includes oxygen therapy, hydration

  3. Histoplasmose disseminada aguda em indivíduo imunocompetente Acute disseminated histoplasmosis in an immunocompetent patient

    Simone Castelo Branco Fortaleza

    2004-06-01

    Full Text Available A histoplasmose é uma doença fúngica causada pela inalação de esporos de Histoplasma capsulatum. A maioria dos indivíduos normais não apresenta doença após pequena inalação, porém exposições mais prolongadas podem levar ao desenvolvimento de infecção pulmonar aguda, crônica ou disseminada. Nos pacientes imunocomprometidos a infecção é disseminada e grave. Relatamos o caso de um paciente de treze anos, imunocompetente, com febre, tosse seca e dispnéia progressiva havia dois meses. O radiograma e a tomografia computadorizada de tórax evidenciavam infiltrado intersticial com micronódulos difusos. O paciente relatava contato intenso com pássaros em sua residência. Foi submetido a biópsia pulmonar a céu aberto, que evidenciou Histoplasma capsulatum em tecido pulmonar. A cultura do fragmento da biópsia confirmou a presença de Histoplasma capsulatum sp. O paciente foi tratado com anfotericina-B por 28 dias, seguida de itraconazol por seis meses, com resolução do quadro.Histoplasmosis is a fungal disease caused by inhalation of Histoplasma capsulatum fungus. The disease does not normally affect immunocompetent individuals after a single, transient inhalation exposure. However, longer exposure may cause chronic or disseminated acute pulmonary infection. In immunocompromised patients, the infection is disseminated and severe. We report the case of a 13-year-old immunocompetent patient, presenting with fever, cough and dyspnea for one month. The chest X-ray and computed tomography scan revealed interstitial infiltrate and diffuse micronodules. The patient reported having had close and prolonged contact with birds. He was submitted to an open lung biopsy and the tissue culture was positive for Histoplasma capsulatum sp. He was treated with amphotericin B for 28 days, followed by treatment with itraconazole for 6 months, and there was complete resolution of the disease.

  4. Toxicidad Oral Aguda de un Fertilizante Foliar (Sharp Oral toxicity of a Fertilizer to Foliate

    Jiménez Parada, Graciela

    2006-04-01

    Full Text Available Se evaluó la Toxicidad Oral Aguda por el método de las Clases de Toxicidad (CTA, de un fertilizante foliar que se identifica como un fertilizante líquido de acción rápida, se aplica en el suelo o por aspersión foliar de acuerdo con el tipo de planta, de su estado fisiológico y uso. Los resultados se analizaron como indica la metodología de la Organización para la Cooperación y Desarrollo Económico (OECD # 423. Para este estudio se emplearon como modelo animal ratas Sprague Dawley. Se detectaron signos de toxicidad evidentes y muerte de animales experimentales en el nivel de dosis de 2000 mg/Kg, no siendo así en el nivel inmediato inferior, 200mg/Kg, por lo que se considera que estos signos de toxicidad observados son inherentes al producto aplicado. Se clasifica a la sustancia en estudio como Peligrosa, en la especie animal utilizada y los niveles de dosis empleados. ABSTRACT.- The Sharp Oral Toxicity was evaluated by the method of the Classes of Toxicity (CTA, of a fertilizer to foliate that it is identified as a liquid fertilizer of quick action, it is applied in the floor or for aspersion to foliate of agreement with the plant type and its physiologic state. The results were analyzed like it indicates the methodology of the Organization for the Cooperation and Economic Development (OECD #423. For this study they were used like model animal rats Sprague Dawley. Evident toxicity signs and death of experimental animals were detected in the level of dose of 2000 mg/Kg, not being this way in the inferior immediate level, 200mg/Kg, for what is considered that these observed toxicity signs are inherent to the applied product. It is classified to the substance in study as Dangerous, in the used animal species and the used dose levels.

  5. Diarrea aguda en trasplantes renales y reno-pancreáticos

    Alberto A Carena

    2015-02-01

    Full Text Available La diarrea es una complicación frecuente y potencialmente grave del trasplante renal. Se describen aquí, en un estudio de corte transversal, las características epidemiológicas y microbiológicas de la diarrea aguda y persistente en pacientes internados con trasplante renal o reno-páncreas. Se incluyeron 52 pacientes internados en un hospital de la Ciudad de Buenos Aires, 42 (80.8% habían recibido un trasplante renal y 10 (19.2% reno-páncreas. La diarrea fue el motivo de ingreso en 34 casos (65.4%. La etiología de la diarrea pudo estudiarse en 50 pacientes: en 25 (50% no se arribó a un diagnóstico etiológico y en 18 (36% se constató diarrea con causa microbiológica específica: 3 (6% enfermedad por citomegalovirus, 6 (12% diarrea atribuida a citomegalovirus, 5 (10% a rotavirus y 4 (8% a Clostridium difficile. En 7 (14% la diarrea fue atribuida a fármacos (mofetil micofenolato y sirolimus. Aquellos con diarrea con causa microbiológica habían recibido recientemente inmunosupresores a altas dosis con mayor frecuencia que el resto (p = 0.048. Los pacientes con diarrea atribuida a fármacos recibían más frecuentemente mofetil micofenolato (p = 0.039. En 16 (30.8% se realizaron modificaciones de los inmunosupresores como medida terapéutica, y a 47 (90.4% se les indicó antibioticoterapia empírica. La mediana de duración de internación fue de 6 días y 7 pacientes (14.6% persistieron con diarrea al quinto día. Todos tuvieron resolución de la diarrea al alta y un tercio persistió con insuficiencia renal. La información de este estudio puede servir para mejorar las medidas preventivas, diagnósticas y terapéuticas en estos pacientes.

  6. Esofagitis necrotizante aguda: Una entidad inusual Acute esophageal necrosis: An unusual entity

    Silvana E. Pramparo

    2010-12-01

    Full Text Available La esofagitis necrotizante aguda (ENA, también denominada esófago negro, es una rara enfermedad poco descripta en la literatura médica. Describimos el caso de un hombre de 80 años, con hemorragia digestiva alta quien desarrolló un esófago negro luego de un episodio de hipotensión. La necrosis fue confirmada histológicamente. Los pacientes se presentan con hematemesis y melena en más del 70% de los casos. Los hallazgos endoscópicos muestran una coloración negruzca de la mucosa esofágica. El diagnóstico se realiza con endoscopia y confirmación histológica. La mortalidad es alta (más del 50% aunque relacionada a las enfermedades de base del paciente. Por último, podemos decir que la sospecha es muy importante en el diagnóstico de ENA, particularmente en pacientes ancianos con enfermedades asociadas y evidencia de hemorragia digestiva alta. En este trabajo describimos las características clínicas, endoscópicas e histopatológicas de un paciente con ENA.Acute esophageal necrosis (AEN, also designated black esophagus, is a rare disorder that is poorly described in the medical literature. We present the case of an 80 years old man, with upper gastrointestinal bleeding who developed a black esophagus after hypotensive episodes. Necrosis was confirmed histologically. Hematemesis and melena are present in more than 70% of the cases. Endoscopic findings show black discoloration of the distal esophagus with proximal extension ending sharply at the gastroesophageal junction. Diagnosis is reached endoscopically with histological support. Mortality is high (up to 50% even though related to the patient's underlying condition. Finally, we may say that to keep in mind the posibility of AEN is a key factor in its diagnosis, particularly in older patients with associated morbidity and evidence of upper gastrointestinal bleeding. In the present report we describe the clinical, endoscopic and histophatological characteristics of a patient with a

  7. Rinovirus: Frecuencia en niños con infección respiratoria aguda, no internados

    Débora N. Marcone

    2012-02-01

    Full Text Available Los métodos moleculares para diagnosticar rinovirus humanos (RVH han aumentado la sensibilidad de detección. Esto ha permitido documentar la asociación entre los RVH y las infecciones respiratorias agudas (IRA altas y bajas. La infección por RVH durante la infancia se asoció con posterior desarrollo de asma. Se estudió la frecuencia de RVH en 186 niños menores de 6 años ambulatorios con IRA (alta o baja, durante 2 años consecutivos (1/6/2008 - 31/5/2010. Se correlacionó la presencia de RVH con los antecedentes y características clínico-epidemiológicas. La detección de RVH se realizó con una RT-PCR en tiempo real que amplifica parte de la región 5' no codificante del genoma. Los virus respiratorios clásicos se estudiaron por inmunofluorescencia. En el 61% de los niños se detectó etiología viral. Las frecuencias fueron: RVH 27%, virus sincicial respiratorio (VSR 16%, influenza A y B 9%, parainfluenza 8%, metapneumovirus 7% y adenovirus 0.5%. Se observaron coinfecciones duales en 8 casos, siendo RVH el más frecuente (en 4 de ellos. Los RVH circularon durante todo el período estudiado, con picos en invierno y primavera. No se observaron diferencias clínico-epidemiológicas significativas entre pacientes con o sin RVH, excepto un mayor porcentaje de niños afebriles con RVH. Los RVH fueron los virus más detectados en niños ambulatorios, principalmente en menores de 2 años, los segundos virus asociados a bronquiolitis, luego del VSR, y detectados tres veces más en los niños expuestos a tabaquismo pasivo (OR: 2,91; p = 0.012 que en el resto. Fueron identificados como único agente en el 28% de las bronquiolitis.

  8. Sindrome confusional agudo por abstinencia aguda de nicotina Delirium due to acute nicotine withdrawal

    Manuel Klein

    2002-08-01

    Full Text Available El síndrome confusional agudo (SCA o delirium en pacientes hospitalizados es un problema frecuente y grave. Se caracteriza por síntomas de comienzo agudo y curso fluctuante con inatención, pensamiento desorganizado, y con distintos niveles de alteración de la conciencia.En la bibliografía consultada, el SCA como manifestación de un síndrome de abstinencia aguda nicotínica fue descripto en solo ocho casos. Presentamos el caso de un tabaquista grave que, internado por una reagudización de su enfermedad pulmonar obstructiva crónica (EPOC, presentó un cuadro de SCA al tercer día de abstinencia tabacal, cediendo los síntomas tras la administración de un parche de nicotina. Lo descripto sugiere que en pacientes internados que presentan SCA y agitación, con fuertes antecedentes de tabaquismo, un simple ensayo con un parche de nicotina puede ofrecer en pocas horas una notable respuesta terapéutica y a su vez un test confirmatorio. El reconocimiento del SCA como forma de presentación de la abstinencia nicotínica permitirá identificar casos habitualmente complejos en los que se podrá implementar una sencilla y eficaz alternativa terapéutica.Delirium or acute confusional state among hospitalized patients is a frequent and serious problem. It is characterized by acute onset symptoms, fluctuating course, impaired attention, unorganized thinking, and altered level of conciousness. Delirium, as a manifestation of acute nicotine withdrawal syndrome has been reported in the reviewed literature only in eight cases. We report the case of a heavy smoker admitted because of a reagudization of his chronic obstructive pulmonary disease. At the third day of nicotine abstinence, he developed delirium with a rapid improvement of his symptoms after treatment with a transdermal nicotine patch. This description suggests that in hospitalized heavy smokers who develop delirium with agitation, a simple trial with a nicotine patch can offer a dramatic

  9. Injúria Renal Aguda no paciente politraumatizado Acute Renal Injury in polytrauma patients

    Thiago Gomes Romano

    2013-03-01

    Full Text Available A Injúria Renal Aguda (IRA no contexto do paciente politraumatizado ocorre, na maioria das vezes, por uma conjuntura de fatores que passam por eventos correlacionados à ressuscitação volêmica inicial, ao grau de resposta inflamatória sistêmica associada ao trauma, ao uso de contraste iodado para procedimentos diagnósticos, à rabdomiólise e à síndrome compartimental abdominal. Atualmente, passamos por uma fase de uniformização dos critérios diagnósticos da IRA com o Acute Kidney Injury Network (AKIN, sendo a referência mais aceita. Consequentemente, o estudo da IRA no politraumatismo também passa por uma fase de reformulação. Esta revisão da literatura médica visa trazer dados epidemiológicos, fisiológicos e de implicação clínica para o manuseio destes pacientes, bem como expor os riscos do uso indiscriminado de expansores volêmicos e particularidades sobre a instituição de terapia renal substitutiva em indivíduos sob risco de hipertensão intracraniana.Acute Kidney Injury (AKI in trauma is, in most cases, multifactorial. Factors related to the initial ressuscitation protocol, degree of the systemic inflamatory response to trauma, contrast nephropathy in diagnostic procedures, rhabdomyolysis and abdominal compartment syndrome are some of those factors. Nowadays a uniformization in diagnostic criteria for AKI has been proposed by the Acute Kidney Injury Network (AKIN and as a result the incidence of AKI and its impact in outcomes in trauma patients also needs to be reconsider. In this review we aim to approach epidemiologic, physiologic and clinical relevant data in the critical care of patients victims of trauma and also to expose the risks of indiscriminate use of volume expanders and the interaction between renal replacement theraphy and intracranial hypertension.

  10. Intoxicación aguda por inhalación de Acrilato de Etilo, Lima 2002

    Jeannette Ávila VM

    2005-10-01

    Full Text Available Objetivos: Describir las características clínico-epidemiológicas de los casos de intoxicación aguda por inhalación de acrilato de etilo, ocasionado por el manejo clandestino de un envase con restos de ésta sustancia, en una urbanización del distrito Comas, en Lima, Perú en noviembre del año 2002. Materiales y métodos: Estudio transversal analítico realizado en residentes y población del centro educativo aledaño a la zona del accidente. Se realizó una encuesta a todas las personas expuestas, se consideró como caso la presencia de cefalea, irritación ocular, nauseas, dolor abdominal y prurito intenso en el cuerpo. Se caracterizó el accidente en tiempo, espacio y persona. En el centro educativo se exploraron factores de exposición que favorecieron la presencia de intoxicados. Los datos fueron ingresados en Epi Info v 6.0 y analizados en STATA v.8.0 Resultados: Se encuestó 456 residentes y 326 personas en la escuela. La tasa de ataque general fue 21,9%, 46,9% en la escuela y 4,2% en viviendas. Los síntomas predominantes fueron cefalea 56%, irritación ocular 47%, dolor abdominal 42%. El 23% requirió hospitalización. El permanecer en pisos superiores de la escuela fue un factor de riesgo OR 4,54 (IC95% 2,66-7,84 y en el pabellón A OR 3,82 (IC95% 2,33-6,25. Conclusiones: Los síntomas predominantes fueron cefalea, irritación ocular y dolor abdominal. La cercanía a la zona de exposición del cilindro y la dispersión de los vapores tóxicos influyeron para afectar mayormente a la escuela y a aquellos que ocupaban aulas en pisos superiores y el pabellón A. La legislación peruana debe contemplar el problema del manejo clandestino de residuos peligrosos.

  11. Intoxicación aguda por plaguicidas Acute poisoning from pesticides

    Jaime Jesús Durán-Nah

    2000-02-01

    Full Text Available OBJETIVO: Describir la epidemiología de la intoxicación aguda por plaguicidas (IAP en el Hospital General O'Horán de Mérida, Yucatán, México. MATERIAL Y MÉTODOS: Se revisaron los expedientes de 33 pacientes ³ 13 años, tratados en una unidad de cuidados intensivos (UCI, entre 1994 y 1998. Se recopilaron variables demográficas y clínicas relevantes, y se aplicó estadística descriptiva. RESULTADOS: En la población estudiada predominó el sexo masculino (82% del medio rural (70%, y la edad media fue de 34 ± 15.8 años. El intento de suicidio fue causa frecuente de IAP (79%, y en 33% de los casos la intoxicación se produjo por la utilización de organofosforados. La mortalidad fue de 12%. CONCLUSIONES: La IAP fue baja entre los sujetos del medio rural, por lo que los resultados de este estudio parecen no reflejar la realidad del problema. Es importante añadir que los plaguicidas son utilizados con relativa frecuencia para el intento de suicidio.OBJECTIVE: To describe the epidemiologic pattern of acute pesticide poisoning (APP in a general hospital in Merida, Yucatan, Mexico. MATERIAL AND METHODS: From 1994 to 1998, 33 patients 13 years of age or older with diagnosis of APP were studied. Descriptive statistics were used to analyze information. RESULTS: Males were frequently affected (82%, specially those coming from rural areas (60%. The mean age of the group was 34 ± 15.8 years. In 79% of the cases, pesticides were used to commit suicide and 33% of poisoning cases were due to organophospate pesticides. The mortality rate was 12%. CONCLUSIONS: In this small sample, acute poisoning from pesticides in the agricultural setting may be underestimated, since it was less frequent than in the general population. APP was more commonly used by indigent people to commit suicide.

  12. Osteomielite hematogênica aguda em Pediatria: análise de casos atendidos em hospital universitário Osteomielitis hematogénica aguda en Pediatría: análisis de casos atendidos en hospital universitario Pediatric acute hematogenous osteomyelitis: analysis of patients assisted in a university hospital

    Pedro Fiorini Puccini; Maria Aparecida G Ferrarini; Antônio Vladir Iazzetti

    2012-01-01

    OBJETIVO: Descrever a ocorrência, a evolução e o desfecho de pacientes com osteomielite hematogênica aguda na faixa etária pediátrica. MÉTODOS: Estudo descritivo de 21 casos de pacientes de zero a 14 anos com diagnóstico de osteomielite hematogênica aguda, em acompanhamento no Ambulatório de Infectologia Pediátrica da Escola Paulista de Medicina entre 2005 e 2009. A coleta de dados ocorreu pelo levantamento de prontuários. Realizaram-se a análise descritiva e o teste de correlação de Spearman...

  13. A Radically Configurable Six-State Compound

    Barnes, Jonathan C.; Fahrenbach, Albert C.; Cao, Dennis; Dyar, Scott M.; Frasconi, Marco; Giesener, Marc A.; Benítez, Diego; Tkatchouk, Ekaterina; Chernyashevskyy, Oleksandr; Shin, Weon Ho; Li, Hao; Sampath, Srinivasan; Stern, Charlotte L.; Sarjeant, Amy A.; Hartlieb, Karel J.

    2013-01-01

    Most organic radicals possess short lifetimes and quickly undergo dimerization or oxidation. Here, we report on the synthesis by radical templation of a class of air- and water-stable organic radicals, trapped within a homo[2]catenane composed of two rigid and fixed cyclobis (paraquat-p-phenylene) rings. The highly energetic octacationic homo[2]catenane, which is capable of accepting up to eight electrons, can be configured reversibly, both chemically and electrochemically, bet...

  14. Quantitative determination of atmospheric hydroperoxyl radical

    Springston, Stephen R. (Upton, NY); Lloyd, Judith (Westbury, NY); Zheng, Jun (Stony Brook, NY)

    2007-10-23

    A method for the quantitative determination of atmospheric hydroperoxyl radical comprising: (a) contacting a liquid phase atmospheric sample with a chemiluminescent compound which luminesces on contact with hydroperoxyl radical; (b) determining luminescence intensity from the liquid phase atmospheric sample; and (c) comparing said luminescence intensity from the liquid phase atmospheric sample to a standard luminescence intensity for hydroperoxyl radical. An apparatus for automating the method is also included.

  15. Photodynamically generated bovine serum albumin radicals

    Silvester, J A; Timmins, G S; Davies, Michael Jonathan

    1998-01-01

    Porphyrin-sensitized photoxidation of bovine serum albumin (BSA) results in oxidation of the protein at (at least) two different, specific sites: the Cys-34 residue giving rise to a thiyl radical (RS.); and one or both of the tryptophan residues (Trp-134 and Trp-214) resulting in the formation of...... by a range of proteases. The generation of protein-derived radicals also results in an enhancement of photobleaching of the porphyrin, suggesting that protein radical generation is linked to porphyrin photooxidation....

  16. Involvement of free radicals in breast cancer

    Ríos-Arrabal, Sandra; Artacho-Cordón, Francisco; León, Josefa; Román-Marinetto, Elisa; del Mar Salinas-Asensio, María; Calvente, Irene; Núñez, Maria Isabel

    2013-01-01

    Researchers have recently shown an increased interest in free radicals and their role in the tumor microenvironment. Free radicals are molecules with high instability and reactivity due to the presence of an odd number of electrons in the outermost orbit of their atoms. Free radicals include reactive oxygen and nitrogen species, which are key players in the initiation and progression of tumor cells and enhance their metastatic potential. In fact, they are now considered a hallmark of cancer. ...

  17. Suspected acute toxoplasmosis in pregnant women Suspeita de toxoplasmose aguda em gestantes

    Marcela Peres Castilho-Pelloso

    2007-02-01

    Full Text Available OBJECTIVE: To determine the prevalence of reagent serology for suspected acute toxoplasmosis in pregnant women and to describe clinical, laboratory and therapeutic profiles of mothers and their children. METHODS: A retrospective study was conducted with IgM-anti-Toxoplasma gondii-reagent pregnant women and their children who attended the public health system in the state of Paraná, Southern Brazil, from January 2001 to December 2003. Information were obtained from clinical, laboratory (ELISA IgM/IgG and ultrasonographic data and from interviews with the mothers. To test the homogeneity of the IgM indices in relation to the treatment used, the Pearson's Chi-square test was applied. Comparisons were considered significant at a 5% level. RESULTS: Two hundred and ninety (1.0% cases of suspected IgM-reagent infection were documented, with a prevalence of 10.7 IgM-reagent women per 1,000 births. Prenatal care started within the first 12 weeks for 214/290; 146/204 were asymptomatic. Frequent complaints included headaches, visual disturbance and myalgia. Ultrasonography revealed abnormalities in 13 of 204 pregnancies. Chemoprophylaxis was administered to 112/227; a single ELISA test supported most decisions to begin treatment. Pregnant women with IgM indices =2.000 tended to be treated more often. Among exposed children, 44/208 were serologically followed up and all were IgG-reagent, and three IgM-reagent cases showed clinical symptoms. CONCLUSIONS: The existence of pregnant women with laboratorially suspected acute toxoplasmosis who were not properly followed up, and of fetuses that were not adequately monitored, shows that basic aspects of the prenatal care are not being systematically observed. There is need of implementing a surveillance system of pregnant women and their children exposed to T. gondii.OBJETIVO: Determinar a prevalência de gestantes com sorologia reagente suspeita de toxoplasmose aguda e descrever as variáveis maternas e do

  18. Avaliação ultra-sonográfica da apendicite aguda Ultrasonographic evaluation of acute appendicitis

    Orlando Jorge Martins Torres

    2001-02-01

    Full Text Available OBJETIVO: A apendicite aguda é a mais comum urgência cirúrgica abdominal. Na tentativa de aumentar a acurácia diagnóstica a ultra-sonografia abdominal tem sido observada como método sensível e específico. O presente estudo tem por objetivo avaliar a ultra-sonografia do abdome no diagnóstico de apendicite aguda. MÉTODO: Um total de 138 pacientes submetidos a tratamento cirúrgico com suspeita diagnóstica admitidos no Hospital Municipal Djalma Marques foi estudado no período de janeiro de 1997 a dezembro de 1998. Todos os exames foram realizados na mesma instituição e havia 87 pacientes do sexo masculino (63,0% e 51 do sexo feminino (37,0% com idade variando de 11 a 81 anos (média de 28,4 anos. RESULTADOS: Dos 134 casos com diagnóstico comprovado cirurgicamente, o estudo ultra-sonográfico foi positivo em 114 (sensibilidade de 85,0%. O apêndice foi visualizado como imagem longitudinal ou transversal maior do que 7mm em 75 dos 114 achados positivos (65,8%. CONCLUSÕES: Os autores concluem que a ultra-sonografia abdominal é um instrumento valioso no diagnóstico de apendicite aguda.BACKGROUND: Acute appendicitis is the most common disease leading to emergency abdominal surgery. Many diagnostic tools have been evaluated. Abdominal ultrasonography is sensitive and specific which increase diagnostic accuracy in acute appendicitis. The aim of the present study is to evaluate the abdominal ultrasonography in the diagnosis of acute appendicitis. METHOD: A total of 138 patients underwent surgical treatment for suspected appendicitis admitted to the Hospital Municipal Djalma Marques from January 1997 to December 1998. All abdominal ultrasonography examinations were performed at same hospital. There were 87 male (63.0% and 51 female (37.0%, and their ages ranged from 11 to 81 years (mean 28.4 years. RESULTS: Of the 134 patients with proved appendicitis at surgery the ultrasonographic diagnosis was positive in 114 (sensitivity of 85.0%. The

  19. Estrategia de atención de niños hospitalizados por infecciones respiratorias agudas bajas

    Ferrari Ana M

    2002-01-01

    Full Text Available OBJETIVO: Mejorar la calidad de la atención hospitalaria de los niños con infecciones respiratorias agudas bajas, aumentar los conocimientos sobre esa patología y mejorar la eficiencia en el uso de los recursos asistenciales, por medio de una estrategia que se denominó Plan de Invierno.MÉTODOS: La estrategia se basó en la utilización de protocolos de diagnóstico y tratamiento, internación por cuidados progresivos y por enfermedad, adecuación de los recursos asistenciales y creación de un sistema de registro permanente, informatizado. Se incorporó la investigación sistemática de la etiología viral para racionalizar el uso de la medicación y reducir las infecciones intrahospitalarias. RESULTADOS: Durante la aplicación del Plan (19/V-19/IX/99 ingresaron 3.317 niños; 1.347 (40.61% presentaban infecciones respiratorias agudas bajas. Se captaron 1.096 (81%, de los cuales 71% eran menores de un año. Predominaron las infecciones respiratorias virales (68%. Los criterios de ingreso fueron saturación de oxígeno <95%, polipnea, tiraje o derrame pleural en el 92.4% de los niños. La magnitud de la demanda impidió que las pautas de aislamiento individual o en grupo se cumplieran en todos los casos. El uso de la medicación se ajustó a lo recomendado en un elevado porcentaje: no recibieron antibióticos 73% de las bronquiolitis ni 72% de las neumonías virales, y 96% de las neumonias bacterianas los recibieron según pauta; se redujo el uso de broncodilatadores y de corticoides. El gasto en medicamentos disminuyó fundamentalmente en el grupo de los corticoides y tuvo el mayor impacto en el costo por día/cama de antibióticos. CONCLUSIONES: Disminuir la morbimortalidad por infecciones respiratorias agudas bajas requiere continuar mejorando la calidad de la atención hospitalaria y fortalecer los programas de promoción de salud y de control de las enfermedades prevalentes, en el primer nivel de atención.

  20. Estrategia de atención de niños hospitalizados por infecciones respiratorias agudas bajas

    Ana M Ferrari

    2002-06-01

    Full Text Available OBJETIVO: Mejorar la calidad de la atención hospitalaria de los niños con infecciones respiratorias agudas bajas, aumentar los conocimientos sobre esa patología y mejorar la eficiencia en el uso de los recursos asistenciales, por medio de una estrategia que se denominó Plan de Invierno.MÉTODOS: La estrategia se basó en la utilización de protocolos de diagnóstico y tratamiento, internación por cuidados progresivos y por enfermedad, adecuación de los recursos asistenciales y creación de un sistema de registro permanente, informatizado. Se incorporó la investigación sistemática de la etiología viral para racionalizar el uso de la medicación y reducir las infecciones intrahospitalarias. RESULTADOS: Durante la aplicación del Plan (19/V-19/IX/99 ingresaron 3.317 niños; 1.347 (40.61% presentaban infecciones respiratorias agudas bajas. Se captaron 1.096 (81%, de los cuales 71% eran menores de un año. Predominaron las infecciones respiratorias virales (68%. Los criterios de ingreso fueron saturación de oxígeno <95%, polipnea, tiraje o derrame pleural en el 92.4% de los niños. La magnitud de la demanda impidió que las pautas de aislamiento individual o en grupo se cumplieran en todos los casos. El uso de la medicación se ajustó a lo recomendado en un elevado porcentaje: no recibieron antibióticos 73% de las bronquiolitis ni 72% de las neumonías virales, y 96% de las neumonias bacterianas los recibieron según pauta; se redujo el uso de broncodilatadores y de corticoides. El gasto en medicamentos disminuyó fundamentalmente en el grupo de los corticoides y tuvo el mayor impacto en el costo por día/cama de antibióticos. CONCLUSIONES: Disminuir la morbimortalidad por infecciones respiratorias agudas bajas requiere continuar mejorando la calidad de la atención hospitalaria y fortalecer los programas de promoción de salud y de control de las enfermedades prevalentes, en el primer nivel de atención.

  1. Avaliação da toxicidade aguda do extrato aquoso de Apeiba tibourbou Aubl (Tiliaceae, em camundongos e ratos

    Luiz Carlos da Cunha

    2013-08-01

    Full Text Available O teste de toxicidade aguda estima a dose letal mediana (DL50 e classifica os toxicantes quanto à periculosidade, inclusive para extratos de plantas. A espécie Apeiba tibourbou Aubl (Tiliaceae, conhecida como paude-jangada ou pente-de-macaco, é empregada popularmente como antirreumática, antiespasmódica e expectorante, embora seja desconhecida quanto aos seus efeitos tóxicos. Assim, o objetivo desta pesquisa foi investigar o potencial de toxicidade aguda do extrato aquoso de A. tibourbou (EAT, administrado por gavagem, em camundongos fêmeas e ratos fêmeas, seguindo as diretrizes OECD Guideline 423/2001 e o screening hipocrático. Os camundongos fêmeas foram divididos em três grupos de três animais cada (C1 – controle, água filtrada, 0,25 mL; C2 – 300 mg/kg de EAT; e C3 – 2000 mg/kg de EAT. Os ratos fêmeas foram divididos em dois grupos de três animais cada (R1 – controle, água filtrada, 0,5 mL; e R2 – 2000 mg/ kg de EAT. O grupo C2 consumiu 28% de água a mais que o grupo C1 (p < 0,05; o grupo C3 produziu 31% de excretas a mais que o grupo C1 (p < 0,0001; o grupo R2 reduziu o consumo de ração e a produção de excretas em 20% e 28% em relação ao grupo R1 (p < 0,05, respectivamente. No screening hipocrático, nenhuma alteração motora e/ou sensorial foi observada. Não houve morte nem estado moribundo de nenhum animal. Conclui-se que o EAT possui DL50 estimada maior que 2000 mg/kg (Classe 5 de toxicidade, segundo o Globally Harmonized System – GHS, ONU, demonstrando reduzido potencial de toxicidade aguda.

  2. Optimal pain management for radical prostatectomy surgery

    Joshi, Grish P; Jaschinski, Thomas; Bonnet, Francis; Kehlet, Henrik

    2015-01-01

    evidence to develop an optimal pain management protocol in patients undergoing radical prostatectomy. Most studies assessed unimodal analgesic approaches rather than a multimodal technique. There is a need for more procedure-specific studies comparing pain and analgesic requirements for open and minimally...... invasive surgical procedures. Finally, while we wait for appropriate procedure specific evidence from publication of adequate studies assessing optimal pain management after radical prostatectomy, we propose a basic analgesic guideline.......BACKGROUND: Increase in the diagnosis of prostate cancer has increased the incidence of radical prostatectomy. However, the literature assessing pain therapy for this procedure has not been systematically evaluated. Thus, optimal pain therapy for patients undergoing radical prostatectomy remains...

  3. Near-Ring Radicals and Class Pairs

    L.Godloza; N.J.Groenewald; W.A.Olivier

    2005-01-01

    For near-ring ideal mappings p1 and p2, we investigate radical theoretical properties of and the relationship among the class pairs (p1: p2), (Sp2: Sp1) and (Rp2:Rp1). Conditions on p1 and p2 are given for a general class pair to form a radical class of various types. These types include the Plotkin and KA-radical varieties. A number of examples are shown to motivate the suitability of the theory of Hoehnke-radicals over KA-radicals when radical pairs of near-rings are studied. In particular, it is shown that (pc: P3) forms a KA-radical class, where Pc denotes the class of completely prime nearrings and P3 the class of 3-prime near-rings. This gives another near-ring generalization of the 2-primal ring concept. The theory of radical pairs are also used to show that in general the class of 3-semiprime near-rings is not the semisimple class of the 3-prime radical.

  4. Dynamics of Radical-Mediated Enzyme Catalyses

    Warncke, Kurt

    1997-11-01

    An emergent class of enzymes harnesses the extreme reactivity of electron-deficient free radical species to perform some of the most difficult reactions in biology. The regio- and stereo-selectivity achieved by these enzymes defies long-held ideas that radical reactions are non-specific. The common primary step in these catalyses is metal- or metallocenter-assisted generation of an electron-deficient organic "initiator radical". The initiator radical abstracts a hydrogen atom from the substrate, opening a new reaction channel for rearrangement to the product. Our aim is to elucidate the detailed molecular mechanisms of the radical pair separation and radical rearrangement steps. Radical pair separation and substrate radical rearrangement are tracked by using time-resolved (10-7 to 10-3 s) techniques of pulsed-electron paramagnetic resonance spectroscopy (FT-EPR, ESEEM). Synchronous time-evolution of the reactions is attained by triggering with a visible laser pulse. Transient non-Boltzmann population of the states of the spin-coupled systems, and resultant electron spin polarization, facilitates study at or near room temperature under conditions where the enzymes are operative. The systems examined include ethanolamine deaminase, a vitamin B12 coenzyme-dependent enzyme, ribonucleotide reductase and photosynthetic reaction centers. The electronic and nuclear structural and kinetic information obtained from the pulsed-EPR studies is used to address how the initiator radicals are stabilized against deleterious recombination with the metal, and to distinguish the participation of concerted versus sequential rearrangement pathways.

  5. The Games Radicals Play: Special Issue on Free Radicals and Radical Ions

    John C. Walton

    2015-02-01

    Full Text Available Chemistry and Physics have aptly been described as “most excellent children of Intellect and Art” [1]. Both these “children” engage with many playthings, and molecules rank as one of their first favorites, especially radicals, which are amongst the most lively and exciting. Checking out radicals dancing to the music of entropy round their potential energy ballrooms is surely both entertaining and enlightening. Radicals’ old favorite convolutions are noteworthy, but the new styles, modes and arrangements appearing on the scene are even more interesting. Some of these are ephemeral and enjoy only a brief appearance, others are retro-types reappearing in new guises, still others are genuinely new and “go viral” in the scientific world. This Special Issue of Molecules contains the observations and reflections of a select group of chemists and physicists fascinated by this spectacle. It contains an eclectic mix reflecting on new modes and advances as well as on permutations and combinations that revive mature themes. [...

  6. Photoionisation of the tropyl radical

    Kathrin H. Fischer

    2013-04-01

    Full Text Available We present a study on the photoionisation of the cycloheptatrienyl (tropyl radical, C7H7, using tunable vacuum ultraviolet synchrotron radiation. Tropyl is generated by flash pyrolysis from bitropyl. Ions and electrons are detected in coincidence, permitting us to record mass-selected photoelectron spectra. The threshold photoelectron spectrum of tropyl, corresponding to the X+ 1A1’ ← X 2E2” transition, reveals an ionisation energy of 6.23 ± 0.02 eV, in good agreement with Rydberg extrapolations, but slightly lower than the value derived from earlier photoelectron spectra. Several vibrations can be resolved and are reassigned to the C–C stretch mode ν16+ and to a combination of ν16+ with the ring breathing mode ν2+. Above 10.55 eV dissociative photoionisation of tropyl is observed, leading to the formation of C5H5+ and C2H2.

  7. Radical surgery in septic abortion.

    Chatterjee, P; Ghosh, M; Ghosh, S

    1979-08-01

    At R.G. Kar Medical College Hospital, Calcutta, 10 cases of septic abortion from 1975-1977 were studied. Hysterectomies were preformed on 4 cases due to emergency situations including traumatised uterine fundus and perforated cervix, and on 6 cases after conservative treatment. Upon performing laparotomy in 9 cases, a uterine rent was detected; in 1 case there was a perforation in the posterior wall of the cervix, and in 5 cases mechanical obstructions due to internal adhesions to the uterine rent were found. 4 patients died primarily because of the patients seeking help too late. It is suggested that under high risk circumstances, laparotomy is advantageous to conservative medical management since bowel injuries and mechanical obstructions can only be detected by laparotomy. Radical surgery, however, should be undertaken before the patients general condition deteriorates to the point that the patient cannot tolerate surgical intervention. PMID:12336028

  8. Students' Ideas and Radical Constructivism

    Sánchez Gómez, Pedro J.

    2016-08-01

    In this article, I study, from the point of view of the analytic philosophy of mind, the compatibility of students' ideas studies (SIS) with radical constructivism (RC). I demonstrate that RC is based on a psychology of narrow mental states; that is, the idea that the mental content of an individual can be fully characterised without any reference external to her or him. I show that this fact imposes some severe restrictions to SIS to be incorporated into RC. In particular, I argue that only qualitative studies can comply with the requirement of narrowness. Nevertheless, I propose that quantitative works can be employed as sources of types in order to study token actual students. I use this type-token dichotomy to put forward an outline of a theory of the relation between school contents and mental contents. In this view, token mental contents regarding a given topic can be defined, and probed, only by resorting to typical school contents.

  9. Students' Ideas and Radical Constructivism

    Sánchez Gómez, Pedro J.

    2016-04-01

    In this article, I study, from the point of view of the analytic philosophy of mind, the compatibility of students' ideas studies (SIS) with radical constructivism (RC). I demonstrate that RC is based on a psychology of narrow mental states; that is, the idea that the mental content of an individual can be fully characterised without any reference external to her or him. I show that this fact imposes some severe restrictions to SIS to be incorporated into RC. In particular, I argue that only qualitative studies can comply with the requirement of narrowness. Nevertheless, I propose that quantitative works can be employed as sources of types in order to study token actual students. I use this type-token dichotomy to put forward an outline of a theory of the relation between school contents and mental contents. In this view, token mental contents regarding a given topic can be defined, and probed, only by resorting to typical school contents.

  10. Iron and iron derived radicals

    Borg, D.C.; Schaich, K.M.

    1987-04-01

    We have discussed some reactions of iron and iron-derived oxygen radicals that may be important in the production or treatment of tissue injury. Our conclusions challenge, to some extent, the usual lines of thought in this field of research. Insofar as they are born out by subsequent developments, the lessons they teach are two: Think fastexclamation Think smallexclamation In other words, think of the many fast reactions that can rapidly alter the production and fate of highly reactive intermediates, and when considering the impact of competitive reactions on such species, think how they affect the microenvironment (on the molecular scale) ''seen'' by each reactive molecule. 21 refs., 3 figs., 1 tab.

  11. Inhibitory effects of chitosan on superoxide anion radicals and lipid free radicals

    2002-01-01

    With the electron spin resonance (ESR) technique, the inhibitory effects of chitosan on superoxide anion radicals and linoleic acid lipid radicals were found. The inhibitory ratio E for these two kinds of radicals is in proportion to the concentration of chitosan. It was also observed that E for linoleic acid lipid radicals increased with the increase of the degree of deacetylation and decreased with the increase of the molecular weight of chitosan.

  12. Insuficiencia renal aguda asociada a picadura de abeja africanizada Acute renal failure secondary to africanized bee stings

    Verny Huertas-Franco

    2008-03-01

    Full Text Available Se presenta el caso de un adulto mayor diabético tipo 2, que sufrió un ataque masivo de abejas africanizadas, y llegó a la sala de emergencias tres horas después del inicio del ataque. El paciente presentó insuficiencia renal aguda por combinación de factores, y se recuperó con tratamiento de diálisis temprana. Se discuten los problemas que refieren estos pacientes, y cuál sería el manejo ideal de tales casos.This is the case of an elderly patient who suffered multiple Africanized bee stings. He developed acute renal failure as a complication. He however recovered completely after treatment with peritoneal dialysis and hemodialysis.

  13. Toxicidad aguda oral y subcrónica en ratas de un extracto acuoso liofilizado de Ocimum tenuiflorum L

    A Lagarto; J Tillán; V Bueno; I Chávez; Guerra, I.; Vega, Y.; Valdés, O.; T Gabilondo

    2005-01-01

    El potencial tóxico de un extracto acuoso liofilizado fue evaluado mediante el ensayo de toxicidad aguda oral y subcrónica a 90 días en ratas Wistar de ambos sexos. Los métodos empleados fueron los descritos por las normas OECD. En el ensayo agudo se administró por vía oral la dosis de 2000 mg/kg y en el ensayo subcrónico 250, 500 y 1000 mg/kg/día durante 13 semanas. Se evaluaron los signos tóxicos y peso corporal en ambos ensayos. En el estudio subcrónico además se evalu...

  14. Toxicología aguda oral del extracto lipídico de Acrocomia crispa en ratones NMRI

    Ariadne Gutiérrez Martínez; Carlos Nodal Flores; Isury Bucarano Lliteras; Eddy Goicochea Carrero

    2016-01-01

    El D-005 es un extracto lipídico del fruto de A. crispa (palma corojo), que contiene una mezcla de ácidos grasos, principalmente láurico, oleico, mirístico y palmítico. El tratamiento con D-005 por vía oral redujo el agrandamiento prostático inducido por testosterona en ratas. Se realizó el ensayo de toxicidad del D-005 con el objetivo de determinar los efectos tóxicos del D-005 administrado por vía oral, a ratones NMRI de ambos sexos. Se utilizó el método de las clases de toxicidad aguda, ad...

  15. Intoxicaciones agudas por cocaína: Caracterización, factores de riesgo, conocimientos y precauciones de los consumidores

    Santos Sanz, Sara

    2012-01-01

    La cocaína es la tercera droga ilegal más consumida después del cannabis y las anfetaminas. España es uno de los países donde su consumo está más extendido, sobretodo en el grupo de adultos jóvenes de 15-34 años. Los problemas de salud asociados al consumo de cocaína son frecuentes (13%-30%) entre los consumidores, aunque la intoxicación aguda por cocaína así como sus factores de riesgo no se han estudiado tanto como en el caso de la sobredosis por heroina. Existen vacios en la literatura sob...

  16. Efecto del ejercicio físico basado en el juego en la leucemia linfocítica aguda

    González García, Laura Ximena; Escobar Zabala, Paola Andrea

    2012-01-01

    Objetivo: Establecer el efecto de un programa de ejercicio físico (EF) basado en el juego sobre el Síndrome de Desacondicionamiento Físico (SDF) de niños con Leucemia Linfocítica Aguda (LLA) entre 5-12 años. Materiales y Métodos: Se realizó un estudio cuasi-experimental con la participación de siete niños tratados por LLA en el Instituto Nacional de Cancerología (INC). Se hizo una evaluación inicial de los determinantes de la condición física (capacidad aeróbica, fuerza muscular, flexibil...

  17. Intercambio gaseoso en el síndrome de dificultad respiratoria aguda Gas exchange in acute respiratory distress syndrome

    G. A. Raimondi

    2003-01-01

    El síndrome de dificultad respiratoria aguda (ARDS) se caracteriza por presentar alteraciones severas del intercambio gaseoso (IG) causadas por «shunt» e importante irregularidad de la ventilación perfusión (V A/Q). Esto es consecuencia del edema intersticial y el colapso y ocupación alveolar. Además de la fracción inspirada de oxígeno y la evolución de la patología pulmonar, hay distintas variables que son capaces de alterar la presión parcial de oxígeno arterial (PaO2). Es así que los cambi...

  18. Uncária tomentosa e a lesão renal aguda isquêmica em ratos

    Maria de Fátima Fernandes Vattimo

    2011-03-01

    Full Text Available O objetivo deste estudo foi avaliar o efeito renoprotetor do fitoterápico Uncaria tomentosa sobre a lesão renal aguda isquêmica induzida pelo clampeamento dos pedículos renais de ratos. A hipóxia e a hipoperfusão geradas com a isquemia intensificam a produção de espécies reativas já presentes no processo inflamatório. Os resultados mostraram que a função renal avaliada pelo clearance de creatinina, a excreção de peróxidos urinários (FOX e a excreção urinária de malondealdeído (TBARS desses animais apresentou renoproteção induzida pela UT, provavelmente relacionada às suas atividades antioxidantes.

  19. Oclusão arterial aguda de stent fêmoro-poplíteo Acute femoropopliteal artery stent obstruction

    Fabio Henrique Rossi

    2009-09-01

    Full Text Available A oclusão aguda de stent fêmoro-poplíteo pode ser causa de isquemia crítica dos membros inferiores. A terapia fibrinolítica pode não ser a forma de tratamento mais indicada para o grupo de pacientes com esse quadro clínico. Neste artigo, apresentamos um caso em que a retirada de um fragmento de stent por endarterectomia tornou possível a revascularização do membro.Femoropopliteal stent obstruction may be responsible for acute lower limb ischemia. Fibrinolytic treatment may not be the best therapeutic approach in this group of patients. We report a clinical case in which stent fragmentation and endarterectomy enabled femoropopliteal below knee bypass and limb revascularization.

  20. Oclusão arterial aguda por derivados da ergotamina Acute arterial occlusion caused by ergotamine derivatives

    Edison Barreto de Souza; Márcia Marinho Gomes de Araújo

    2009-01-01

    Os derivados da ergotamina compõem diversas drogas amplamente utilizadas no tratamento de ataques agudos de migrânea. A intoxicação por estas substâncias resulta geralmente de sua administração crônica, promovendo sintomas secundários ao espasmo arterial e à consequente isquemia distal. Neste artigo, é relatado o caso de uma paciente de 47 anos com diagnóstico de oclusão arterial aguda em membros inferiores secundária ao uso de derivados da ergotamina. Após a suspensão da droga e a prescrição...

  1. Deleción terminal del brazo largo del cromosoma 9 en leucemia promielocítica aguda

    Herrera JC.; Cristancho CM.; Durango NE.; Ramírez JL; Sierra M.; Botero OL.; Taknida T.; Posada A.; Vásquez G.

    2011-01-01

    La Leucemia Promielocítica Aguda (LPA), definida como M3 en la clasificación francesa-americana- británica (FAB)(1), se caracteriza por presentar una translocación cromosómica al azar t(15;17)(q22;q21). En esta translocación se fusionan los receptores del ácido retinoíco ?(? RAR) gen localizado en el cromosoma 17 y el gen PML sobre el cromosoma 15(2). Por otra lado, la deleción del brazo largo del cromosoma 9(9q-) es una alteración rara específica encontrada en (LMA) como una anormalidad únic...

  2. Cirurgia conservadora da endocardite bacteriana aguda da valva tricúspide Conservative operation for bacterial endocardites of the tricuspide valve

    Iseu Affonso da Costa

    1988-08-01

    Full Text Available É relatado o caso de 1 paciente que apresentou endocardite aguda da valva tricúspide pós-aborto, cujo agente causal era o S. aureus. Como não houvesse resposta favorável ao tratamento antibiótico (gentamicina, vancomicina e oxacilina, optou-se pela intervenção, vinte dias após a internação. Foi praticada excisão de uma vegetação única e do tecido valvar adjacente, na comissura ântero-posterior e plicatura anular. O resultado foi favorável, com cura clínica. O exame ecocardiográfico confirmou a presença da vegetação no pré-operatório e o funcionamento conservado da valva, após a plastia. O tratamento cirúrgico, com retirada do tecido infectado e preservação da valva constitui uma alternativa aplicável a certos casos de endocardite aguda das valvas atrioventriculares.One case of acute bacterial endocarditis of the tricuspid valve caused by S. aureus and following a septic abortion is presented. Surgical treatment was indicated after failure of antibiotics. Operation consisted of excision of a large vegetation adherent to the anterior and posterior cusps at the commisure and of the affected valvar tissue. Annular plicature at the segment corresponding to the posterior cuspid was employed to maintain competence. Clinical result was very satisfactory with resolution of sepsis. Dopplerecocardiography revealed the presence of the vegetation before the operation and showed a small regurgitation after valvoplasty. Conservative operation upon the atrioventricular valves must be kept in mind as an alternative in the treatment of acute bacterial endocarditis.

  3. Apendicite aguda: achados na tomografia computadorizada - ensaio iconográfico Acute appendicitis: computed tomography findings - an iconographic essay

    Marcelo Eustáquio Montandon Júnior

    2007-06-01

    Full Text Available A apendicite aguda é a causa mais comum de dor abdominal aguda que requer intervenção cirúrgica no mundo ocidental. O diagnóstico precoce é essencial para minimizar a morbidade da doença. O uso dos métodos de imagem significou grande avanço no diagnóstico desta entidade, até então avaliada apenas com base na história clínica, exame físico e dados laboratoriais, haja vista que 20% a 33% dos pacientes apresentam sintomas atípicos. O diagnóstico é mais difícil nas crianças, nos idosos e nas mulheres em idade fértil. Os principais métodos de imagem para sua avaliação são a ultra-sonografia e a tomografia computadorizada. Os objetivos deste trabalho são: descrever a fisiopatologia da doença, comentar os principais aspectos técnicos da tomografia computadorizada, demonstrar e ilustrar os achados tomográficos e citar os principais diagnósticos diferenciais.Acute appendicitis is the most important cause of abdominal pain requiring surgical intervention in the Western world. The early diagnosis of this disease is of paramount relevance for minimizing its morbidity. Imaging methods have represented a huge progress in the diagnosis of this entity, which used to be based essentially on clinical history, physical examination and laboratory tests results, considering that 20% to 33% of patients present with atypical symptoms. Diagnostic difficulty is higher in children, the elderly, and women in childbearing age. The main imaging methods for evaluation of acute appendicitis are ultrasound and computed tomography. The present study is aimed at describing the disease physiopathology, commenting main computed tomography technical aspects, demonstrating and illustrating tomographic findings, and describing main differential diagnoses.

  4. Toxicología aguda oral del extracto lipídico de Acrocomia crispa en ratones NMRI

    Ariadne Gutiérrez Martínez

    2016-01-01

    Full Text Available El D-005 es un extracto lipídico del fruto de A. crispa (palma corojo, que contiene una mezcla de ácidos grasos, principalmente láurico, oleico, mirístico y palmítico. El tratamiento con D-005 por vía oral redujo el agrandamiento prostático inducido por testosterona en ratas. Se realizó el ensayo de toxicidad del D-005 con el objetivo de determinar los efectos tóxicos del D-005 administrado por vía oral, a ratones NMRI de ambos sexos. Se utilizó el método de las clases de toxicidad aguda, administrando una dosis de 2 000 mg/kg de peso corporal. Luego de la única administración, los animales fueron observados diariamente durante 14 d. Las variables analizadas fueron: mortalidad y signos clínicos, peso corporal, consumo de alimento y observaciones macroscópicas. No existieron diferencias significativas en ninguna de estas variables entre el grupo tratado y el control en ninguno de los sexos. No se evidenció ningún efecto tóxico relacionado con el tratamiento. El D-005 presentó una toxicidad intrínseca baja, mostrando una toxicidad superior a los 2 000 mg/kg de peso corporal, dosis a la que no se evidenciaron signos indicativos de toxicidad en ninguno de los sexos, por lo que su toxicidad se puede declarar como no clasificable según el método de las clases de toxicidad aguda.

  5. Daño pulmonar agudo relacionado con la transfusión (Trali y Bartonelosis aguda

    Douglas López de Guimaraes

    2006-07-01

    Full Text Available Se presenta el caso de un varón de 22 años procedente de la periferia de la ciudad de Huaraz, Perú, que acude al Hospital "Victor Ramos Guardia" de Huaraz con un tiempo de enfermedad de 14 días, febril, pálido e ictérico, en el frotis de sangre periférica se encuentran formas bacilares de Bartonella bacilliformis en 99% de la lámina; se inicia tratamiento antibiótico con ceftriaxona y ciprofloxacino. Al día siguiente se le indica transfusión de dos paquetes globulares (puesto que tenía 6,2 g/dL de Hb, dos horas después presenta dolor toráxico, tos seca exigente, vómitos, dificultad respiratoria y cianosis, en la auscultación se encuentran roncantes y crepitantes, la radiografía de tórax muestra infiltrado alveolar difuso a predominio derecho. Es trasladado a la UCI donde recibe oxígeno con máscara de reservorio, dopamina, corticoides y se inicia el monitoreo hemodinámico; responde en forma satisfactoria, sale de alta con frotis negativo a Bartonella bacilliformis. Es el primer caso de daño pulmonar agudo relacionado con la transfusión (TRALI asociado con Bartonelosis aguda con cuadro clínico - radiológico y evolución compatible, es importante distinguir entre la complicación pulmonar debido a la sepsis grave por Bartonelosis aguda, que puede producir un cuadro clínico similar y el TRALI.

  6. Acute myeloid leukaemia induced by mitoxantrone: case report Leucemia mielóide aguda induzida por mitoxantrone: relato de caso

    Walter Oleschko Arruda

    2005-06-01

    Full Text Available Mitoxantrone (MX is an immunosupressant drug used in secondarily progressive multiple sclerosis (SPMS and in relapsing-remitting multiple sclerosis (RRMS. It has a leukemogenesis potential induced by cytogenetic abnormalities, though with a low incidence. Promyelocitic leukaemia (type M3 and other forms of acute myeloblastic leukaemias (M4 and M5 have been described in a few MS patients who received MX during their treatment. We describe a white female patient, 47 year-old, with SPMS (EDSS = 4 with 14 years of disease. She received MX during her disease and developed acute promyelocytic leukaemia (M3, with severe thrombocytopenia 30 months later. She ultimately died due to intracerebral hemorrhage. Other cases of treatment related to AML are reviewed and discussed.Mitoxantrone (MX é uma agente imunossupressor utilizado nas formas progressivas secundárias de esclerose múltipla (EM ou formas surto-remissão sem resposta com outras formas de tratamento (p.ex. beta-interferon, acetato de glatirâmer. Com o uso desta medicação, ocorre uma incidência maior, embora pequena, de desenvolvimento de leucemia mielóide aguda induzida por quimioterápicos. Descrevemos o caso de uma paciente com forma progressiva secundária de EM, submetida a uma dose única de MX de 15mg e que 30 meses após desenvolveu quadro fulminante de leucemia promieloblástica aguda (M3, com trombocitopenia grave. A paciente faleceu por hemorragia intracerebral maciça. É feita revisão de outros casos relatados na literatura e os possíveis mecanismos de desenvolvimento desta complicação grave secundária ao uso do MX.

  7. Resultados del tratamiento de leucemia linfoblástica aguda en niños.

    Margarita Quintero de Charry

    2009-10-01

    Full Text Available El objetivo general de este estudio fue evaluar los resultados de las fases de inducción, consolidación y reinducción del tratamiento de la leucemia linfoblástica aguda (LLA, utilizado en el Hospital Universitario del Valle (HUV, durante el período comprendido entre enero, 1993 y abril, 1999. Se estudiaron 2 grupos de niños con LLA: 52 de bajo riesgo y 57 de alto riesgo. Se asignaron a diferentes protocolos de quimioterapia, de acuerdo con los criterios de clasificación de riesgo establecidos. Se utilizaron la prueba de chi cuadrado (c2 y la prueba exacta de Fisher para analizar las características de cada cohorte. Se obtuvieron riesgos relativos e intervalos de confianza del 95% para evaluar la asociación entre la edad, el recuento de leucocitos al momento del diagnóstico, la morfología Franco-Américo-Británica (FAB, y la presencia de remisión completa al final de la inducción, con el desarrollo de recaídas, remisión sostenida y muerte. El análisis de supervivencia libre de eventos se realizó con el método de Kaplan-Meier y se compararon las curvas utilizando la prueba de "log rank". No se encontraron diferencias estadísticamente significativas en las tasas de remisión completa entre el grupo de bajo riesgo (94.2% y el de alto riesgo (89.4% (p=0.36; 71% de los niños que lograron remisión completa, permanecieron en remisión sostenida (p=0.00. La incidencia acumulada de recaídas fue mayor en los niños de alto riesgo que en los de bajo riesgo (RR 2.2; IC 95% 1.10-4.70; 94.9% de los pacientes que no hicieron recaídas lograron permanecer en remisión sostenida hasta el final del período de observación (p=0.00. La supervivencia libre de eventos fue más pobre en el grupo de bajo riesgo (40% que en el de riesgo alto (50%, prueba de "log rank"=0.049. Desde el punto de vista biológico, los niños de bajo riesgo deberían tener una mejor supervivencia que los de alto riesgo, como se informa en la literatura. La pobre

  8. Radical Behaviorism and Buddhism: Complementarities and Conflicts

    Diller, James W.; Lattal, Kennon A.

    2008-01-01

    Comparisons have been made between Buddhism and the philosophy of science in general, but there have been only a few attempts to draw comparisons directly with the philosophy of radical behaviorism. The present review therefore considers heretofore unconsidered points of comparison between Buddhism and radical behaviorism in terms of their…

  9. Radical-Local Teaching and Learning

    Hedegaard, Mariane; Chaiklin, Seth

    radical-local teaching and learning approach. The first half of the book introduces the idea of radical-local teaching and learning and develops the theoretical background for this perspective, drawing on the cultural-historical research tradition, particularly from Vygotsky, El'konin, Davydov...

  10. What Is Radical in School Geography Today?

    Morgan, John

    2011-01-01

    This article addresses the question of what "radical school geography" might look like in the present historical moment. It traces the history of a distinctive "radical" tradition in school geography, most prominently associated with the work of John Huckle, who argued for the importance of understanding the content and pedagogy of school…

  11. Free Radical Mechanisms in Autoxidation Processes.

    Simic, Michael G.

    1981-01-01

    Discusses the use of steady-state radiation chemistry and pulse radiolysis for the generation of initial free radicals and formation of peroxy radicals in the autoxidation process. Provides information regarding the autoxidation process. Defines autoxidation reactions and antioxidant action. (CS)

  12. Physicochemical aspects of isomerisation of free radicals

    Denisov, Evgenii T; Denisova, Taisa G [Institute of Problems of Chemical Physics, Russian Academy of Sciences, Chernogolovka, Moscow Region (Russian Federation)

    2004-11-30

    Kinetic data on intramolecular abstraction of hydrogen atoms in alkyl, alkoxyl and peroxyl radicals are generalised and analysed. It is shown that the activation energies of these reactions are affected by ring strain. The kinetic parameters of mono- and bimolecular elimination reactions are compared. The difference between the activation energies of these reactions is interpreted using the model of intersecting parabolas. The same model is used to discuss the results of analysis of cyclisation of alkyl radicals; the ring strain energy is shown to play an important role in the activation of these reactions. It is noted that the difference between the electron affinities of the C, N and O atoms is clearly manifested in the cyclisation of aminyl and {omega}-formylalkyl radicals. The kinetic parameters of cyclisation and bimolecular radical addition reactions are compared. The experimental data on the transfer of the vinyl and aryl groups in alkyl radicals are analysed.

  13. Hydroxyl-radical-induced oxidation of cyclic dipeptides: Reactions of free peptide radicals and their peroxyl radicals

    In the course of this study investigations were carried out into the reactions of hydroxyl radicals and hydrogen atoms with cyclic dipeptides as well as the subsequent reactions of peptide radicals and their peroxyl radicals in aqueous solution. The radiolysis products formed in the absence and presence of oxygen or transient metal complexes were characterized and determined on a quantitative basis. The linking of information from product analyses to the kinetic data for transient species obtained by time-resolving UV/VIS and conductivity measurements (pulse radiolysis) as well as computer-assisted simulations of individual events during the reaction permitted an evaluation of the mechanisms underlying the various processes and an identification of interim products with short life-times, which did or did not belong to the group of radicals. Through the characterization of key reactions of radicals and peroxyl radicals of this substance class a major advance has been made towards a better understanding of the role of radicals in the peptide compound and the mechanisms involved in indirect radiation effects on long-chain peptides and proteins. (orig.)

  14. ORGASMIC FUNCTION AFTER RADICAL PROSTATECTOMY

    D. Yu. Pushkar

    2014-07-01

    Full Text Available Objective: to study orgasmic function (OF in patients undergoing radical prostatectomy (RPE.Subjects and methods. Seventy-nine patients who had undergone RPE for locally advanced prostate cancer without hormone and radiation therapies were examined. The patients’ mean age was 59.3 years. The mean EF-IIEF domain score was 24.4. OF was estimated by IIEF question 10 and the authors’ questionnaire. The Spearman rank correction coefficient and Mann-Whitney U-Wilcoxon tests were used.Results. After RPE, there was a reduction in the mean IIEF question 10 score from 3.9 (confidence interval 3.7–4.1 to 3.3 (3–3.5 (p = 0.000. The following changes were found in orgasm intensity: no changes in 43 %, mild worsening in 42 %, severe worsening in 8 %, and enhancement in 4 %; orgasm could not be achieved in 4 % of the patients. Pain usually of low intensity was reported by 8.8 %. The poor factors for preserving OF were its low baseline level, elderly age, or severe post-RPE erectile dysfunction.Conclusion. There were significant OF changes after RPE, which should be kept in mind while treating this category of patients.

  15. Bacteriemia por Elizabethkingia meningoseptica en paciente con leucemia linfoblástica aguda Bacteriemia by Elizabethkingia meningoseptica in acute linfoblastic leukemia patients

    Lina María Echeverri; Sigifredo Ospina

    2010-01-01

    Se reporta un caso de bacteriemia por Elizabethkingia meningoseptica en un paciente inmunocomprometido, con antecedentes de leucemia linfoblástica aguda, que ingresa por infiltración al sistema nervioso central y sospecha de proceso infeccioso. Elizabethkingia meningoseptica es una bacteria oportunista en infecciones intrahospitalarias, con notable resistencia antimicrobiana, la cual es un inusual patógeno en humanos.A case report of bacteraemia by Elizabethkingia meningoseptica in an immunoc...

  16. Implicación de rs924607 del gen CEP72 en la neurotoxicidad asociada a la vincristina en pacientes con leucemia linfoblastica aguda (LLA)

    De Vicente Martínez, Beatriz

    2016-01-01

    Este trabajo se trata de un estudio estadístico de asociación entre el genotipo del SNP rs924607 presente en la región promotora del gen CEP72, y la neurotoxicidad asociada a la vincristina, en pacientes pediátricos de Leucemia Linfoblástica Aguda. El objetivo es determinar si el alelo presente en dicho SNP puede ser empleado como biomarcador para predecir la neurotoxicidad asociada a la vincristina.

  17. Acute schistosomiasis: clinical, diagnostic and therapeutic features Esquistossomose aguda: aspectos clínicos, diagnósticos e terapêuticos

    J. R. Lambertucci

    1993-10-01

    Full Text Available Three distinct syndromes caused by schistosomiasis have been described: cercarial dermatitis or swimmer's itch, acute schistosomiasis or Katayama fever, and chronic schistosomiasis. Complications of acute schistosomiasis have also been reported. The absence of a serological marker for the acute stage has hindered early diagnosis and treatment. Recently, an ELISA test using KLH (keyhole limpet haemocyanin as antigen, has proved useful in differentiating acute from chronic schistosomiasis mansoni. Clinical and experimental evidence indicate that steroids act synergistically with schistosomicides in the treatment of Katayama syndrome. In this paper, clinical, diagnostic and therapeutic features of acute schistosomiasis are updated.A esquistossomose apresenta-se clinicamente em três formas distintas: dermatite cercariana, esquistossomose aguda ou febre de Katayama e esquistossomose crônica. Há na literatura relatos de complicações da fase aguda. A ausencia de um marcador sorológico simples e confiável tem dificultado o diagnóstico precoce e, como consequência, o tratamento adequado de pacientes na fase aguda da doença. Recentemente, o teste de ELISA, realizado com o antígeno KLM (hemocianina do caramujo Megathura crenulata, tem se mostrado util na identificação dos pacientes com febre de Katayama. Evidências clínicas e experimentais apontam no sentido de uma ação sinérgica entre os corticosteróides e os esquistossomicidas no tratamento da esquistossomose toxêmica. Neste artigo, alguns aspectos clínicos, diagnósticos e terapêuticos da esquistossomose aguda são atualizados.

  18. Infiltración al quiasma y a los nervios y ópticos en un caso de leucemia mieloblástica aguda

    Toro G., Gabriel; Mena R., Hernando; Suárez C., Héctor A.; Pinaud, Rafael

    2011-01-01

    Se presenta el caso de un hombre de 18 años de edad con leucemia mieloblástica aguda quien desarrolló meningitis leucémica con pérdida de la visión, papiledema severo. A la autopsia se encontró marcada infiltración leucémica del quiasma y de los nervios ópticos. Se analiza el compromiso del SNC en leucemia y se revisa la literatura.

  19. Generation of radicals by bimolecular reactions

    Denisov, Evgenii T; Denisova, Taisa G [Institute of Problems of Chemical Physics, Russian Academy of Sciences, Chernogolovka, Moscow Region (Russian Federation)

    2002-05-31

    The published data on bimolecular processes of radical generation in chain degradation, polymerisation, oxidation and halogenation reactions of organic compounds are systematised and analysed within the framework of the parabolic model of homolytic bimolecular reactions. The specific features of these highly endothermic reactions are discussed with a special emphasis on their striking similarity to radical abstraction processes with identical reaction centres in the transition state. The feasibility of theoretical evaluation of the activation energies and the rate constants of bimolecular reactions in radical generation is demonstrated. The bibliography includes 86 references.

  20. Some reactions of oxidizing radicals with enzymes in aqueous solution

    A range of oxidizing radicals including some inorganic radical anions and the superoxide radical, can be generated by radiolysis of aqueous solutions. These radicals are more selective in their reactions with amino acids than the hydroxyl radical. Factors controlling the apparent reactivity of radical anions with proteins, such as free radical equilibria and ion-binding, are described. The superoxide radical inactivates papain by reaction with the cysteine residue. This reaction has been studied in solutions subjected to radiations of varying linear energy transfer. (Auth.)

  1. Radical pancreaticoduodenectomy for benign disease.

    Kavanagh, D O

    2008-01-01

    Whipple\\'s procedure is the treatment of choice for pancreatic and periampullary malignancies. Preoperative histological confirmation of malignancy is frequently unavailable and some patients will subsequently be found to have benign disease. Here, we review our experience with Whipple\\'s procedure for patients ultimately proven to have benign disease. The medical records of all patients who underwent Whipple\\'s procedure during a 15-year period (1987-2002) were reviewed; 112 patients underwent the procedure for suspected malignancy. In eight cases, the final histology was benign (7.1%). One additional patient was known to have benign disease at resection. The mean age was 50 years (range: 30-75). The major presenting features included jaundice (five), pain (two), gastric outlet obstruction (one), and recurrent gastrointestinal haemorrhage (one). Investigations included ultrasound (eight), computerised tomography (eight), endoscopic retrograde cholangiopancreatography (seven; of these, four patients had a stent inserted and three patients had sampling for cytology), and endoscopic ultrasound (two). The pathological diagnosis included benign biliary stricture (two), chronic pancreatitis (two), choledochal cyst (one), inflammatory pseudotumour (one), cystic duodenal wall dysplasia (one), duodenal angiodysplasia (one), and granular cell neoplasm (one). There was no operative mortality. Morbidity included intra-abdominal collection (one), anastomotic leak (one), liver abscess (one), and myocardial infarction (one). All patients remain alive and well at mean follow-up of 41 months. Despite recent advances in diagnostic imaging, 8% of the patients undergoing Whipple\\'s procedure had benign disease. A range of unusual pathological entities can mimic malignancy. Accurate preoperative histological diagnosis may have allowed a less radical operation to be performed. Endoscopic ultrasound-guided fine needle aspirate (EUS-FNA) may reduce the need for Whipple\\'s operation

  2. Radical Pancreaticoduodenectomy for Benign Disease

    D. O. Kavanagh

    2008-01-01

    Full Text Available Whipple's procedure is the treatment of choice for pancreatic and periampullary malignancies. Preoperative histological confirmation of malignancy is frequently unavailable and some patients will subsequently be found to have benign disease. Here, we review our experience with Whipple's procedure for patients ultimately proven to have benign disease. The medical records of all patients who underwent Whipple's procedure during a 15-year period (1987–2002 were reviewed; 112 patients underwent the procedure for suspected malignancy. In eight cases, the final histology was benign (7.1%. One additional patient was known to have benign disease at resection. The mean age was 50 years (range: 30–75. The major presenting features included jaundice (five, pain (two, gastric outlet obstruction (one, and recurrent gastrointestinal haemorrhage (one. Investigations included ultrasound (eight, computerised tomography (eight, endoscopic retrograde cholangiopancreatography (seven; of these, four patients had a stent inserted and three patients had sampling for cytology, and endoscopic ultrasound (two. The pathological diagnosis included benign biliary stricture (two, chronic pancreatitis (two, choledochal cyst (one, inflammatory pseudotumour (one, cystic duodenal wall dysplasia (one, duodenal angiodysplasia (one, and granular cell neoplasm (one. There was no operative mortality. Morbidity included intra-abdominal collection (one, anastomotic leak (one, liver abscess (one, and myocardial infarction (one. All patients remain alive and well at mean follow-up of 41 months. Despite recent advances in diagnostic imaging, 8% of the patients undergoing Whipple'’s procedure had benign disease. A range of unusual pathological entities can mimic malignancy. Accurate preoperative histological diagnosis may have allowed a less radical operation to be performed. Endoscopic ultrasound–guided fine needle aspirate (EUS-FNA may reduce the need for Whipple's operation in

  3. Pancreatitis aguda: Análisis de 97 pacientes Acute pancreatitis: Analysis of 97 patients

    Débora Pellegrini

    2009-04-01

    Full Text Available La pancreatitis aguda (PA es una patología con múltiples etiologías y de curso clínico diverso. En nuestro medio son escasas las comunicaciones acerca de esta entidad y en general abordan temas puntuales dentro del amplio espectro del cuadro. El objetivo de este trabajo es determinar las características clínicas, la etiología, el manejo y la evolución de los pacientes internados en nuestra institución con diagnóstico de PA. Se analizaron retrospectivamente los registros clínicos de los pacientes con diagnóstico de PA entre abril de 2004 y abril de 2007. Se evaluaron los datos poblacionales, etiología, tratamiento instaurado, gravedad y morbimortalidad. En el período analizado, 97 pacientes fueron internados con diagnóstico de PA. Cuarenta y nueve fueron de sexo masculino (50.5%. La edad promedio fue de 58.5 ± 1.6 años (rango 21-93. Noventa y dos pacientes presentaron un solo episodio de PA, y 5 pacientes dos o más episodios (pancreatitis recurrente. Según su etiología, 48 fueron de origen biliar, 23 idiopáticas, 11 post-procedimientos en la vía biliar, 2 de origen alcohólico y 13 de otras causas. La mediana de estadía hospitalaria fue 7 días. El 25% requirió internación en Unidad de Terapia Intensiva. Según la escala de Ranson la mayoría de los pacientes (n: 66; 72% presentaron cuadros leves. La mediana de inicio de alimentación oral fue de 3 días. Con respecto a las complicaciones, 13% presentaron falla multiorgánica, 8% necrosis pancreática (4 infectadas, sólo un paciente desarrolló un seudoquiste y otro un absceso pancreático. La mortalidad fue 7.2% (7 casos, todos con Ranson ≥ 3. La PA de origen biliar resultó ser la más común y si bien la presente es una serie pequeña, llama la atención el bajo número de PA de origen alcohólico. Aunque el número de complicaciones locales fue menor, la mortalidad fue similar a la descripta en la literatura. Nuestros datos también son coincidentes en cuanto al

  4. User involvement competence for radical innovation

    Lettl, Christopher

    One important market related capability for firms which seek to develop radical innovations is the competence to involve the 'right' users at the 'right' time in the 'right' form. While former studies have identified a rather passive role of users in the radical innovation process, this paper...... focuses on the involvement of such users that are in the position to play an active role as inventors and (co)-developers. A multiple case study analysis was conducted in the field of medical technology. Five radical innovation projects within four firms were selected including medical robots and computer......-assisted navigation systems. The case study analysis reveals that firms who closely interact with specific users benefit significantly for their radical innovation work. These users have a high motivation toward new solutions, are open to new technologies, possess diverse competencies, and are embedded into a very...

  5. Radicalization and the Use of Social Media

    Robin Thompson

    2011-01-01

    Full Text Available The use of social media tools by individuals and organizations to radicalize individuals for political and social change has become increasingly popular as the Internet penetrates more of the world and mobile computing devices are more accessible. To establish a construct for radicalization,the power and reach of social media will be described so there is common understanding of what social media is and how it is utilized by various individuals and groups. The second section will answer the question of why social media applications are the perfect platform for the radical voice. Finally, the use of social media and its influence in radicalizing populations in Northern Africa and the Middle East during 2011 will be analyzed and recommendations proposed.

  6. Neo-liberal Governing of 'Radicals'

    Lindekilde, Lasse

    2012-01-01

    The Danish government’s counter-radicalization Action Plan of 2009 had intended and unintended effects. Primarily targeting Danish Muslims, it employs neoliberal governmentality approaches of governance through individual support and response, information and knowledge, empowerment, surveillance ...

  7. Free radical scavenging activity of papaya juice

    Papaya juice is an efficient scavenger of highly reactive hydroxyl radicals (OH radical) formed during 60Co irradiation of water. The OH anion radicals were detected by the electron spin resonance (ESR) technique of spin trapping using DMPO (5,5-dimethyl-1-pyrroline-N-oxide) or by a colorimetric assay in which salicylate is converted into polyhydroxybenzoic acids. Papaya juice is also able to quench the ESR signal of a stable free radical (TEMPOL) and the ESR signal of the DMPO-OH adduct. The active substance(s) in papaya juice are heat-stable, dialyzable, and soluble in water but not in lipid solvents. The active agents do not appear to be ascorbate, tocopherol, or carotenoids. (author)

  8. RADICALLY CONTESTED ASSERTIONS IN ECOSYSTEM MANAGEMENT

    Ecosystem management is a magnet for controversy, in part because some of its formulations rest on questionable assertions that are radically contested. These assertions are important to understanding much of the conflict surrounding ecosystem management and, therrefore, deserve...

  9. Customers as Partners in Radical Service Innovation

    Scupola, Ada; Nicolajsen, Hanne Westh

    2009-01-01

    ongoing collaboration where creativity and trial and error are crucial. These needs require new ways of communicating and interacting between customer and consultants. Originality/value- This article is original because it generates new insights into conditions and challenges in radical innovations in......  Purpose- The main purpose of this paper is to investigate customer involvement and related challenges in radical service innovations in engineering consulting services Design/methodology/approach - The paper uses a case study approach and so called rich descriptions to investigate customer...... involvement, roles and related challenges and conditions in radical service innovations.Findings- One main finding is that customers can engage in radical service innovations in engineering consultancy services and may play a decisive role. In doing this they most likely take on all the three user involvement...

  10. A radical approach to asperparaline C

    Amatov, Tynchtyk; Jahn, Ullrich

    Praha: Czech Chemical Society, 2015. s. 41. [Liblice 2015. Advances in Organic, Bioorganic and Pharmaceutical Chemistry /50./. 06.11.2015-08.11.2015, Olomouc] Institutional support: RVO:61388963 Keywords : asperparalines * bridged diketopiperazines * radical reactions Subject RIV: CC - Organic Chemistry

  11. Innovation Type, Radicalness, and the Adoption Process.

    Damanpour, Fariborz

    1988-01-01

    Reviews studies on the impact of organizational factors on the adoption of innovations along three dimensions (innovation type, innovation radicalness, and stages of adoption), finding considerable agreement. Proposes a research agenda for future studies. (SR)

  12. Rigid Ideals and Radicals of Ore Extensions

    Chan Yong Hong; Tai Keun Kwak; S. Tariq Rizvi

    2005-01-01

    For an endomorphism σ of a ring R, Krempa called σ a rigid endomorphism if aσ(a) = 0 implies a= 0 for a ∈ R. A ring R is called rigid if there exists a rigid endomorphism of R. In this paper, we extend the σ-rigid property of a ring R to an ideal of R. For a σ-ideal Ⅰ of a ring R, we call Ⅰ a σ-rigid ideal if aσ(a) ∈Ⅰ implies a ∈Ⅰ for a ∈ R. We characterize σ-rigid ideals and study related properties. The connections of the prime radical and the upper nil radical of R with the prime radical and the upper nil radical of the Ore extension R[x; σ, δ], respectively, are also investigated.

  13. Fast beam studies of free radical photodissociation

    Neumark, D.M. [Lawrence Berkeley Laboratory, CA (United States)

    1993-12-01

    The authors have developed a novel technique for studying the photodissociation spectroscopy and dynamics of free radicals. In these experiments, radicals are generated by laser photodetachment of a fast (6-8 keV) mass-selected negative ion beam. The resulting radicals are photodissociated with a second laser, and the photofragments are collected and detected with high efficiency using a microchannel plate detector. The overall process is: ABC{sup -} {yields} ABC + e{sup -} {yields} A + BC, AB + C. Two types of fragment detection schemes are used. To map out the photodissociation cross-section of the radical, the photodissociation laser is scanned and the total photofragment yield is measured as a function of wavelength. In other experiments, the photodissociation frequency is fixed and the photofragment masses, kinetic energy release, and scattering angle is determined for each photodissociation event.

  14. Malondialdehyde in early phase of acute pancreatitis Malondialdehído en la fase inicial de la pancreatitis aguda

    Vicent Hernández

    2011-11-01

    Full Text Available Aims: to assess oxidative stress in acute pancreatitis, its evolution over time and its relationship with the severity of the disease. Methods: during a two-year period, patients with acute pancreatitis with less than 24 hours of pain were evaluated. Serum was obtained the first, second and fourth day from admittance, if complications were detected, and after recovery. Malondialdehyde was determined by high performance liquid chromatography. Twenty healthy volunteers constituted the control group. Malondialdehyde between groups was compared with Mann-Whitney and Kruskal-Wallis tests; malondialdehyde evolution was studied with Wilcoxon test. Results: one hundred and sixty-nine patients were included (91 women, median age 67 years, range 20-95; 33 suffered a severe episode. Malondialdehyde decreased from first to fourth day (0.600 vs. 0.451 vs. 0.343 μM, respectively, p 0.05. In severe attacks malondialdehyde was higher than in control group at day 2 (severe: 0.514; mild: 0.440; control: 0.347 μM, p Objetivos: valorar el estrés oxidativo en la pancreatitis aguda, su evolución a lo largo del tiempo y su relación con la gravedad de la enfermedad. Métodos: durante un periodo de dos años, se estudiaron los pacientes ingresados por pancreatitis aguda con dolor abdominal de menos de 24 horas de evolución. Se obtuvo suero de los pacientes el primer, segundo y cuarto día de ingreso, en el momento en que se detectaban complicaciones y tras la recuperación. La concentración de malondialdehído fue determinada utilizando cromatografía líquida de alta resolución. Veinte voluntarios sanos conformaron el grupo control. La concentración de malondialdehído entre los diferentes grupos se comparó utilizando el test de Mann-Whitney y el test de Kruskal-Wallis; la evolución de malondialdehído se valoró mediante el test de Wilcoxon. Resultados: se incluyeron 169 pacientes (91 mujeres, edad mediana 67 años, rango 20-95; 33 sufrieron un episodio

  15. Etnografía de la infección respiratoria aguda en una zona rural del altiplano mexicano

    MARTÍNEZ HOMERO

    1997-01-01

    Full Text Available Objetivo. Identificar los términos utilizados por las madres para referirse a enfermedades, signos y síntomas relacionados con infecciones respiratorias agudas, así como los signos de alarma que las motivan a buscar atención médica; asimismo, describir prácticas comunes de manejo de la enfermedad en el hogar. Material y métodos. Se trata de un estudio etnográfico en seis comunidades rurales del altiplano mexicano. Se entrevistó a 12 informantes clave, a seis madres de niños fallecidos por infección respiratoria aguda, y a 24 madres de niños menores de cinco años, con diversas técnicas etnográficas para complementar la información obtenida ("triangulación". Resultados. Las enfermedades comúnmente identificadas incluyeron gripa, anginas, tos, bronquitis, pulmonía, neumonía y "broncomonía". Los síntomas clave para el diagnóstico fueron escurrimiento de moco nasal, dolor de garganta, tos, dolor de cabeza o de cuerpo, calentura, "hervor" de pecho, y referencias a que el niño "está molesto o llorón", se pone morado o le hace falta el aire. La taquipnea fue referida como "respira fuerte", "respira mucho", "respira rápido" y "tiene sesido"; el tiraje, "se le hunde el pecho"; el estridor, como "quejido o ronquido de pecho"; la sibilancia, como "ronquido de pecho", y para la cianosis; "se pone morado". Entre los tratamientos ofrecidos en el hogar destacan el uso de tés, aplicación de limón, jitomate, tomate o papa en la garganta, y aplicación de sebo o pomada en pecho y espalda. No fue común la autoprescripción de antibióticos pero sí la de antipiréticos. La mayoría de las madres reconoció enfermedades leves y, en menor proporción, graves. Ante un caso grave de insuficiencia respiratoria aguda, la opción más frecuentemente elegida fue acudir a la clínica del proyecto; en segundo lugar al médico particular en la cabecera municipal, y al hospital de la Secretaría de Salud en la Jurisdicción. La cercanía y el

  16. Free radical reactions with subtilisin Carlsberg

    Pulse radiolysis has been used to study the mechanisms of radiation-induced inactivation of enzymes. However, interpretation of the results is often complicated by the fact that the G values for enzyme inactivation are usually much smaller than the G values for the radicals formed from water radiolysis. Where inactivation by oxidative free radical attack is concerned, the problem can often be greatly simplified by the use of the free radical probe technique. These free radicals, which include the halide-type radicals Cl2-, Br2-,I2- and (CNS)2-, react much more selectively than OH radicals with amino acids. They can be used to demonstrate that selective oxidation of certain amino acid residues can lead to enzyme inactivation. The technique assists, therefore, in determining whether such sensitive amino acids are present in the active centre and are crucial to the activity of the protein. A number of enzymes have been studied by this method and the amino acid residues found to be necessary for enzymic activitya are in agreement with those identified by conventional biochemical techniques. In these enzymes, free radical attack by the halide radicals leads to inactivation by damage to a single type of amino acid residue which is involved either in catalysis or binding of the substrate. Subtilisin Carlsberg is a serine protease consisting of a poly-peptide chain lacking both cysteine and cystine residues. This paper indicates the use of the selective probe technique in demonstrating that damage to one or more histidine residues leads to inactivation of the enzyme. (author)

  17. Radicalization and the Use of Social Media

    Robin Thompson

    2011-01-01

    The use of social media tools by individuals and organizations to radicalize individuals for political and social change has become increasingly popular as the Internet penetrates more of the world and mobile computing devices are more accessible. To establish a construct for radicalization,the power and reach of social media will be described so there is common understanding of what social media is and how it is utilized by various individuals and groups. The second section will answer the q...

  18. Modelling of tropospheric ozone and radical chemistry

    Burkert, Jörn

    2003-01-01

    This work describes in detail the photochemistry of ozone and radicals in both remote clean air and heavily polluted regions. The results of two field studies are presented: the Indian Ocean Experiment (INDOEX) and the Peroxy Radical Initiative for Measurements in the Environment (PRIME).The :b:INDOEX:/b: campaign studied the chemistry of remote areas of the Indian Ocean and the influence of the outflow from the Indian subcontinent on these regions. Measurements of trace gases (NMHC, O3, RO2*...

  19. Free Radicals, Antioxidants in Disease and Health

    Pham-Huy, Lien Ai; He, Hua; Pham-Huy, Chuong

    2008-01-01

    Free radicals and oxidants play a dual role as both toxic and beneficial compounds, since they can be either harmful or helpful to the body. They are produced either from normal cell metabolisms in situ or from external sources (pollution, cigarette smoke, radiation, medication). When an overload of free radicals cannot gradually be destroyed, their accumulation in the body generates a phenomenon called oxidative stress. This process plays a major part in the development of chronic and degene...

  20. The stabilization energies of polyenyl radicals

    Luo, Yu-Ran; Holmes, John L.

    1994-10-01

    The resonance stabilization energies, Es, of polyenyl radicals can be estimated by the equation Es( N)=-13.2+[3.95-15.8(2) -2/ n] kcal mol -1, where N is the number of C, C-π bonds in the polyenyl radicals. This correlation has been extended for predicting the weakest HC, CC and COH bond dissociation energies in vitamin A and similar compounds.

  1. OUR 6-YEAR EXPERIENCE IN RADICAL CYSTECTOMY

    Cevdet Kaya; Orhan Koca; Muzaffer Oğuz Keleş; Gülhan Yılmaz; Metin Öztürk; Hüseyin Kanberoğlu; M. İhsan Karaman

    2009-01-01

    Objective: Bladder cancer is the second most common cancer of the urinary tract. Radical cystectomy and urinary diversion is the gold standard treatment model of invasive bladder cancer.Patient and Methods: We evaluated 71 patients who underwent radical cystectomy, retrospectively according to their demographic properties, pre-operative and post-operative pathologies and method of urinary diversion and the complications between January 2003 and 2008.Results: Mean follow-up was 28.8 months aft...

  2. Project Radicalization: Why do "they" hate "us"?

    Eggert, Lasse; Foged, Mathias; Jensen, Martin

    2014-01-01

    The phenomenon of global terrorism is still not fully understood by the international community whether within the contingents of public decision-makers, security agencies and researchers. Radicalization as explanation and analytical tool for understanding terrorism has relatively recently gained new prominence. In this project the question of which discourses can be found in the scientific material within the research field of terrorism and radicalization is addressed. A sample of scientifi...

  3. Uso do sulfato de magnésio venoso para tratamento da asma aguda grave da criança no pronto-socorro

    Tânia Mara Baraky Bittar

    2012-03-01

    Full Text Available A asma aguda grave é uma emergência médica que deve ser diagnosticada e tratada rapidamente. O tratamento inicial inclui broncodilatadores e corticosteróides sistêmicos. Em casos graves, com fraca resposta ao tratamento padrão, o sulfato de magnésio venoso surge como opção terapêutica. O objetivo deste artigo foi revisar a literatura sobre o uso do sulfato de magnésio venoso na asma aguda em crianças no pronto-socorro no que se refere a eficácia, indicação, dosagem, efeitos adversos e contraindicações. Realizada revisão narrativa por meio das Bases de dados Medline, Lilacs e Cochrane Database of Systmatic Reviews, entre 2000 e 2010. Utilizados os descritores: asthma, children, emergency, magnesium sulfate. Incluídos oito ensaios clínicos controlados, três meta-análises, um estudo retrospectivo, oito artigos de revisão e um estudo transversal. A eficácia do magnésio venoso em crianças foi observada por vários autores, com raros efeitos adversos. Seu uso foi indicado para os pacientes com asma aguda moderada e grave que não responderam ao tratamento inicial com broncodilatador e corticosteróide. As contraindicações em pediatria são poucas. Entre elas estão insuficiência renal e bloqueio atrioventricular. Existem poucos relatos da interação do magnésio com drogas de uso pediátrico. Apesar da segurança, na prática, o magnésio venoso é pouco usado na asma aguda em pediatria. Na maioria das vezes, é indicado tardiamente para impedir falência respiratória e internação na unidade de cuidados intensivos. Os estudos demonstram que o magnésio venoso é uma droga eficaz e segura na criança com asma aguda grave, porém o seu uso no pronto-socorro ainda é limitado.

  4. Efecto del calcio sobre la toxicidad aguda de aluminio en alevines de trucha arcoiris (Oncorhynchus mykiss expuestos en aguas de diferente pH

    Rolando Vega

    2015-05-01

    Full Text Available En la producción de alevines de salmón de la región de la Araucanía (sur de Chile se presentan importantes eventos de mortalidad aguda sin rasgos patológicos aparentes. El problema se focaliza en ejemplares de 0,2 a 1 g y las causas apuntan a procesos de acidificación del pH del agua y a la presencia de ciertos metales pesados, entre los cuales destaca el aluminio, que alcanza concentraciones más allá de los rangos de tolerancia de los peces. La información científica indica que concentraciones de 5 mg Ca L-1 en el afluente son suficientes para mantener a salvo los peces del efectos tóxico del aluminio. Sin embargo, los problemas en la producción de alevines de salmón indican que se requiere un mayor conocimiento científico y evidencia experimental que soporte el desarrollo de procesos y tecnologías para el tratamiento de los afluentes de las pisciculturas chilenas. En este trabajo se evaluó el efecto de cuatro concentraciones de calcio (0, 5, 10 y 20 mg Ca L-1 sobre la toxicidad aguda de 500 μg Al L-1 en alevines de trucha arcoiris (Oncorhynchus mykiss de 0,1 g en agua de cultivo a pH 5, 6 y 7. El objetivo del trabajo fue determinar la dosis de calcio que reduce la toxicidad aguda de aluminio y los tiempos mínimos de reacción que podrían disponer los piscicultores para tomar medidas preventivas ante una concentración aguda de aluminio en el agua de cultivo. Los resultados indican que antes de 8 h de exposición a una concentración tóxica de aluminio los piscicultores deberían asegurar en el agua de cultivo una dosis superior a 10 mg Ca L-1 y un pH >6 como medida remedial para reducir el efecto de intoxicación aguda causada por aluminio.

  5. Control of radical chemistry in the AdoMet-radical enzymes

    Duschene, Kaitlin S.; Veneziano, Susan E.; Silver, Sunshine C.; Broderick, Joan B.

    2009-01-01

    The radical AdoMet superfamily comprises a diverse set of >2800 enzymes that utilize iron-sulfur clusters and S-adenosylmethionine (SAM or AdoMet) to initiate a diverse set of radical-mediated reactions. The intricate control these enzymes exercise over the radical transformations they catalyze is an amazing feat of elegance and sophistication in biochemistry. This review focuses on the accumulating evidence for how these enzymes control this remarkable chemistry, including controlling the re...

  6. Reactions of alkoxy radicals in aqueous solutions

    The kinetic and mechanistic properties of alkoxy radicals in organic solvents are briefly reviewed. Owing to the scarcity of such data in aqueous solutions and since reactions at the membrane/water interface may be also biologically important, we have studied the reactivity of these radicals in water and the results of our investigations are reported. Alkoxy radicals were generated by photolytic or radiolytic cleavage of peroxide precursors (tert-butyl hydroperoxide and di-tert-butyl peroxide as well as hydroperoxides of polyunsaturated fatty acids). A quantitative correlation between the structure of various substances, in particular, phenolic antioxidants, and their activity in inhibiting the alkoxy radical-induced bleaching of the water-soluble carotenoid crocin will be discussed. Rate constants for intermolecular reactions of t-BuO. radicals were determined by pulse radiolysis. The diffusion-controlled reaction with the catechol antioxidant nordihydroguaiaretic acid demonstrates an effective competition with the very rapid intra molecular β-fragmentation in water. The results aupport the view that a considerable amount of alkoxy radicals interact with substrates before they can rearrange intramolecularly

  7. Reactions of alkoxy radicals in aqueous solutions

    Bors, W.; Tait, D.; Michel, C.; Saran, M.; Erben-Russ, M. (Gesellschaft fuer Strahlen- und Umweltforschung m.b.H. Muenchen, Neuherberg (Germany, F.R.). Abt. fuer Strahlenbiologie)

    1984-01-01

    The kinetic and mechanistic properties of alkoxy radicals in organic solvents are briefly reviewed. Owing to the scarcity of such data in aqueous solutions and since reactions at the membrane/water interface may be also biologically important, we have studied the reactivity of these radicals in water and the results of our investigations are reported. Alkoxy radicals were generated by photolytic or radiolytic cleavage of peroxide precursors (tert-butyl hydroperoxide and di-tert-butyl peroxide as well as hydroperoxides of polyunsaturated fatty acids). A quantitative correlation between the structure of various substances, in particular, phenolic antioxidants, and their activity in inhibiting the alkoxy radical-induced bleaching of the water-soluble carotenoid crocin will be discussed. Rate constants for intermolecular reactions of t-BuO. radicals were determined by pulse radiolysis. The diffusion-controlled reaction with the catechol antioxidant nordihydroguaiaretic acid demonstrates an effective competition with the very rapid intra molecular ..beta..-fragmentation in water. The results aupport the view that a considerable amount of alkoxy radicals interact with substrates before they can rearrange intramolecularly.

  8. Inactivation of Bacillus atrophaeus by OH radicals

    Ono, Ryo; Yonetamari, Kenta; Tokumitsu, Yusuke; Yonemori, Seiya; Yasuda, Hachiro; Mizuno, Akira

    2016-08-01

    The inactivation of Bacillus atrophaeus by OH radicals is measured. This study aims to evaluate the bactericidal effects of OH radicals produced by atmospheric-pressure nonthermal plasma widely used for plasma medicine; however, in this study, OH radicals are produced by vacuum ultraviolet (VUV) photolysis of water vapor instead of plasma to allow the production of OH radicals with almost no other reactive species. A 172 nm VUV light from a Xe2 excimer lamp irradiates a He–H2O mixture flowing in a quartz tube to photodissociate H2O to produce OH, H, O, HO2, H2O2, and O3. The produced reactive oxygen species (ROS) flow out of the quartz tube nozzle to the bacteria on an agar plate and cause inactivation. The inactivation by OH radicals among the six ROS is observed by properly setting the experimental conditions with the help of simulations calculating the ROS densities. A 30 s treatment with approximately 0.1 ppm OH radicals causes visible inactivation.

  9. Radioprotective thermally generated free-radical dextrins

    Piotr TOMASIK; Oskar MICHALSKI; Ewa BIDZINSKA; Antonina CEBULSKA-WASILEWSKA; Krystyna DYREK; Maciej FIEDOROWICZ; Pawel OLKO

    2008-01-01

    Effect of doses of the X-ray radiation from 0 to 400 Gy upon granular cornstarch and dextrins (British gums, BG) thermally generated from it at 230-300℃ was recognized with quantitative EPR and IR ab-sorption spectroscopy, molecular mass distribution in the depolymerization products, Scanning Elec-tron Microscopy, and X-ray diffractometry. Fractal analysis of the profiles of molecular mass distribu-tion showed that the depolymerization involved debranching of amylopectin. Roasting of cornstarch produced BG which differed in concentration and EPR parameters of stable free radicals from BG generated by X-ray radiation. Two types of stable free radicals, with Gaussian and Lorentzian shapes of EPR signals, were recognized. The shapes of the signals and temperature dependence on free radical intensity indicated exchanging interactions of the antiferromagnetic type, causing partial quenching of the spins at -196℃ (77K). Upon X-ray irradiation, new radicals were generated, the number and stability of which strongly depended on the types of radicals present before irradiation. These radicals slowly ceased because of a repolymerization of BG on storage.

  10. Study of acute hepatotoxicity of Equisetum arvense L. in rats Estudo da hepatotoxicidade aguda da Equisetum arvense L. em ratos

    Nilo César do Vale Baracho

    2009-12-01

    Full Text Available PURPOSE: To evaluate the acute hepatotoxicity of Equisentum arvense L. in rats. METHODS: Fifty Wistar rats were used, these being divided in four groups, one being the control (receiving only water and the other groups receiving graded doses of Equisentum arvense L. (30, 50, and 100mg/kg respectively for 14 days. Blood samples were obtained to determine TGO, TGP, FA, DHL and GT-gamma activities. After that, hepatic tissue samples were collected for the anatomopathologic analysis. RESULTS: The anatomopathologic exam of the hepatic tissue showed organ with preserved lobular structure. In the same way, there was no significant change in the seric activities of the hepatic enzymes when compared to control group. CONCLUSION: The oral treatment with graded doses of Equisentum arvense L. was not able to produce hepatic changes. Further studies are necessary to evaluate the chronic hepatotoxicity of Equisentum arvense L. in rats.OBJETIVO: Investigar a hepatotoxicidade aguda da Equisetum arvense L. em ratos. MÉTODOS: foram utilizados 50 ratos Wistar, os quais foram divididos em quatro grupos, sendo um controle (recebendo apenas água e os outros grupos recebendo doses crescentes de cavalinha (30, 50 e 100mg/Kg, respectivamente por 14 dias. Foram coletadas amostras de sangue para determinação da atividade sérica de TGO, TGP, FA, DHL e gama-GT. Em seguida, foram obtidas amostras de tecido hepático para análise anatomopatológica. RESULTADOS: O exame anatomopatológico de tecido hepático demonstrou órgão com estrutura lobular preservada. Da mesma forma, não houve alteração significativa na atividade sérica das enzimas hepáticas, quando comparado ao grupo controle. CONCLUSÃO: O tratamento com doses crescentes de Equisetum arvense L., não induziu hepatotoxicidade aguda em ratos. Novos estudos são necessários para avaliar a hepatoxicidade crônica de Equisetum arvense L. em ratos.

  11. Lesão pulmonar aguda associada à transfusão Transfusion-related acute lung injury

    Antonio Fabron Junior

    2007-04-01

    Full Text Available Lesão pulmonar aguda associada à transfusão (transfusion-related acute lung injury, TRALI é uma complicação clínica grave relacionada à transfusão de hemocomponentes que contêm plasma. Recentemente, TRALI foi considerada a principal causa de morte associada à transfusão nos Estados Unidos e Reino Unido. É manifestada tipicamente por dispnéia, hipoxemia, hipotensão, febre e edema pulmonar não cardiogênico, que ocorre durante ou dentro de 6 h, após completada a transfusão. Embora o exato mecanismo não tenha sido totalmente elucidado, postula-se que TRALI esteja associada à infusão de anticorpos contra antígenos leucocitários (classes I ou II ou aloantígenos específicos de neutrófilos e a mediadores biologicamente ativos presentes em componentes celulares estocados. A maioria dos doadores implicados em casos da TRALI são mulheres multíparas. TRALI, além de ser pouco diagnosticada, pode ainda ser confundida com outras situações de insuficiência respiratória aguda. Um melhor conhecimento sobre TRALI pode ser crucial na prevenção e tratamento desta severa complicação transfusional.Transfusion-related acute lung injury (TRALI is a serious clinical syndrome associated with the transfusion of plasma-containing blood components. Recently, TRALI has come to be recognized as the leading cause of transfusion-related death in the United States and United Kingdom. This complication typically presents as shortness of breath, hypoxemia, hypotension, fever and noncardiogeneic pulmonary edema, all occurring during or within 6 h after transfusion. Although the mechanism of TRALI has not been fully elucidated, it has been associated with human leukocyte antigen antibodies (class I, class II or neutrophil alloantigens and with biologically active mediators in stored cellular blood components. Most of the donors implicated in cases of TRALI are multiparous women. Rarely diagnosed, TRALI can be confused with other causes of acute

  12. Há evidências favorecendo o uso de betabloqueadores e dobutamina na insuficiência cardíaca aguda?

    Luiz Carlos Santana Passos

    2013-02-01

    Full Text Available Diversos estudos relataram os benefícios dos betabloqueadores (BB para pacientes com insuficiência cardíaca sistólica. No entanto, muitos pacientes hospitalizados em decorrência de insuficiência cardíaca aguda já estão usando os BB e requerem dobutaminas para hipotensão arterial e baixo débito cardíaco. Portanto, deve-se tomar uma decisão a respeito de se o BB deve ser mantido ou até mesmo iniciado nesses casos. O objetivo deste estudo foi determinar se há provas que sustentem a segurança e a eficácia dos BB junto com a dobutamina para pacientes com insuficiência cardíaca aguda descompensada (ICAD. Foi realizada uma pesquisa na literatura de língua inglesa nas bases de dados MEDLINE, ISI Web of Science, Biblioteca Virtual em Saúde, Cochrane Library e o Portal de Revistas Científicas do Capes para identificar estudos relacionados. Literatura adicional foi obtida mediante a análise das respectivas referências encontradas nos artigos identificados. Os resultados esperados incluíram informações sobre o prognóstico (intra-hospitalar e na mortalidade no acompanhamento, número de dias de internação e reinternação, eficácia e segurança (agravamento dos sintomas, choque, intolerância do uso concomitante desses medicamentos em pacientes hospitalizados com ICAD e baixo débito cardíaco. Esta análise incluiu nove estudos. No entanto, não foram encontrados ensaios clínicos randomizados sobre o assunto. A maioria dos estudos inclui baixo número de pacientes, e não foram encontrados estudos que abordem a segurança do uso concomitante desses medicamentos. Os dados resultantes sugerem que uma cuidadosa revisão da literatura não forneceu evidências para o uso sistemático de BB em pacientes com síndrome de baixo débito cardíaco que necessitam de suporte inotrópico com dobutamina.

  13. Transplante de medula óssea em leucemia mielóide aguda Bone marrow transplantation in acute myelogenous leukemia

    Daniel G. Tabak

    2000-04-01

    Full Text Available O transplante de medula óssea constitui terapêutica eficaz no tratamento da leucemia mielóide aguda. Embora utilizado inicialmente em pacientes em fases tardias da doença, os melhores resultados são documentados em pacientes submetidos ao procedimento enquanto em primeira remissão. Avanços no manuseio do paciente neutropênico permitem hoje a utilização com maior segurança de regimes quimioterápicos agressivos que resultam em uma sobrevida prolongada, semelhante àquela observada pós regimes mieloablativos. Ainda existem dúvidas sobre quais os pacientes que deveriam ser submetidos às diferentes modalidades de intensificação. Os estudos citogenéticos e uma melhor definição das características biológicas de cada indivíduo permitirão uma melhor seleção de pacientes. O melhor controle da Doença do Enxerto contra Hospedeiro, o melhor manuseio das complicações infecciosas pós transplante, a utilização de regimes de condicionamento menos agressivos e a maior disponibilidade de doadores não aparentados permite antever uma maior aplicabilidade do transplante de medula óssea alogênico no tratamento da Leucemia Mielóide Aguda, inclusive em pacientes mais idosos. O papel do transplante autólogo precisa ser melhor definido.Bone marrow transplantation represents an effective therapy for acute myelogenous leukemia. Despite its initial use in patients in late stages of their disease, the best results have been documented when the procedure is undertaken while in first complete remission. Recent advances in the management of the neutropenic patient have guaranteed the safe use of aggressive chemoterapy regimens, resulting in a prolonged disease free survival, similar to what is documented after myeloablative regimens. Doubts still remain as of which patients should be submitted to marrow transplantation and at which stage of their disease. Cytogenetics and a better definition of other biological characteristics will allow a

  14. Radicalization and Radical Catalysis of Biomass Sugars: Insights from First-principles Studies

    Yang, Gang; Zhu, Chang; Zou, Xianli; Zhou, Lijun

    2016-01-01

    Ab initio and density functional calculations are conducted to investigate the radicalization processes and radical catalysis of biomass sugars. Structural alterations due to radicalization generally focus on the radicalized sites, and radicalization affects H-bonds in D-fructofuranose more than in D-glucopyranose, potentially with outcome of new H-bonds. Performances of different functionals and basis sets are evaluated for all radicalization processes, and enthalpy changes and Gibbs free energies for these processes are presented with high accuracy, which can be referenced for subsequent experimental and theoretical studies. It shows that radicalization can be utilized for direct transformation of biomass sugars, and for each sugar, C rather than O sites are always preferred for radicalization, thus suggesting the possibility to activate C-H bonds of biomass sugars. Radical catalysis is further combined with Brønsted acids, and it clearly states that functionalization fundamentally regulates the catalytic effects of biomass sugars. In presence of explicit water molecules, functionalization significantly affects the activation barriers and reaction energies of protonation rather than dehydration steps. Tertiary butyl and phenyl groups with large steric hindrances or hydroxyl and amino groups resulting in high stabilities for protonation products drive the protonation steps to occur facilely at ambient conditions. PMID:27405843

  15. Radicalization and Radical Catalysis of Biomass Sugars: Insights from First-principles Studies

    Yang, Gang; Zhu, Chang; Zou, Xianli; Zhou, Lijun

    2016-07-01

    Ab initio and density functional calculations are conducted to investigate the radicalization processes and radical catalysis of biomass sugars. Structural alterations due to radicalization generally focus on the radicalized sites, and radicalization affects H-bonds in D-fructofuranose more than in D-glucopyranose, potentially with outcome of new H-bonds. Performances of different functionals and basis sets are evaluated for all radicalization processes, and enthalpy changes and Gibbs free energies for these processes are presented with high accuracy, which can be referenced for subsequent experimental and theoretical studies. It shows that radicalization can be utilized for direct transformation of biomass sugars, and for each sugar, C rather than O sites are always preferred for radicalization, thus suggesting the possibility to activate C-H bonds of biomass sugars. Radical catalysis is further combined with Brønsted acids, and it clearly states that functionalization fundamentally regulates the catalytic effects of biomass sugars. In presence of explicit water molecules, functionalization significantly affects the activation barriers and reaction energies of protonation rather than dehydration steps. Tertiary butyl and phenyl groups with large steric hindrances or hydroxyl and amino groups resulting in high stabilities for protonation products drive the protonation steps to occur facilely at ambient conditions.

  16. Control of radical chemistry in the AdoMet-radical enzymes

    Duschene, Kaitlin S.; Veneziano, Susan E.; Silver, Sunshine C.; Broderick, Joan B.

    2009-01-01

    Summary The radical AdoMet superfamily comprises a diverse set of >2800 enzymes that utilize iron-sulfur clusters and S-adenosylmethionine (SAM or AdoMet) to initiate a diverse set of radical-mediated reactions. The intricate control these enzymes exercise over the radical transformations they catalyze is an amazing feat of elegance and sophistication in biochemistry. This review focuses on the accumulating evidence for how these enzymes control this remarkable chemistry, including controlling the reactivity between the iron-sulfur cluster and AdoMet, and controlling the subsequent radical transformations. PMID:19269883

  17. Control of radical chemistry in the AdoMet radical enzymes.

    Duschene, Kaitlin S; Veneziano, Susan E; Silver, Sunshine C; Broderick, Joan B

    2009-02-01

    The radical AdoMet superfamily comprises a diverse set of >2800 enzymes that utilize iron-sulfur clusters and S-adenosylmethionine (SAM or AdoMet) to initiate a diverse set of radical-mediated reactions. The intricate control these enzymes exercise over the radical transformations they catalyze is an amazing feat of elegance and sophistication in biochemistry. This review focuses on the accumulating evidence for how these enzymes control this remarkable chemistry, including controlling the reactivity between the iron-sulfur cluster and AdoMet, and controlling the subsequent radical transformations. PMID:19269883

  18. Sumário de atualização da II Diretriz Brasileira de Insuficiência Cardíaca Aguda 2009/2011

    Marcelo Westerlund Montera

    2012-05-01

    Full Text Available Nos últimos dois anos, observamos diversas modificações na abordagem diagnóstica e terapêutica dos pacientes com Insuficiência Cardíaca aguda (IC aguda, o que nos motivou quanto à necessidade da realização de um sumário de atualização da II Diretriz Brasileira de Insuficiência Cardíaca Aguda de 2009. Na avaliação diagnóstica, o fluxograma diagnóstico foi simplificado e foi fortalecido o papel da avaliação clínica e ecocardiograma. Na avaliação clínico-hemodinâmica admissional, o ecocardiograma hemodinâmico ganhou destaque no auxilio da definição dessa condição no paciente com IC aguda na sala de emergência. Na avaliação prognóstica, os biomarcadores tiveram seu papel mais bem estabelecido, e a síndrome cardiorrenal teve seus critérios e valor prognóstico mais bem definidos. Os fluxogramas de abordagem terapêutica foram revistos, tornando-se mais simples e objetivos. Dentre os avanços na terapêutica medicamentosa destacam-se a segurança e a importância da manutenção ou introdução dos betabloqueadores na terapêutica admissional. A anticoagulação, de acordo com as novas evidências, ganha um espectro maior de indicações. O edema agudo de pulmão tem bem estabelecido os seus modelos hemodinâmicos de apresentação com suas distintas formas de abordagens terapêuticas, com novos níveis de indicação e evidência. No tratamento cirúrgico da IC aguda, a revascularização miocárdica, a abordagem das lesões mecânicas e o transplante cardíaco foram revistos e atualizados. Este sumário de atualização fortalece a II Diretriz Brasileira de Insuficiência Cardíaca Aguda por mantê-la atualizada e rejuvenescida. Todos os clínicos cardiologistas que lidam com pacientes com IC aguda encontrarão na diretriz e em seu sumário de atualização importantes instrumentos no auxílio da prática clínica para o melhor diagnóstico e tratamento de seus pacientes.

  19. Efeitos hemodinâmicos da sobrecarga ventricular direita aguda experimental Efectos hemodinámicos de la sobrecarga ventricular derecha aguda experimental Hemodynamic effects of experimental acute right ventricular overload

    Flávio Brito Filho

    2011-04-01

    Full Text Available FUNDAMENTO: A sobrecarga ventricular direita aguda está associada a situações clínicas de elevada morbimortalidade, tais como: ressecções pulmonares extensas, tromboembolismo pulmonar, transplante pulmonar e edema pulmonar das altitudes. Alguns pontos de sua fisiopatologia permanecem obscuros. OBJETIVO: Avaliar os efeitos hemodinâmicos da sobrecarga ventricular direita aguda experimental em suínos. MÉTODOS: A sobrecarga ventricular direita foi induzida pela oclusão das artérias pulmonares através de ligaduras. Vinte porcos foram utilizados no estudo, sendo alocados em 04 grupos: um controle, não submetido à oclusão vascular pulmonar, e três de sobrecarga ventricular direita submetidos à oclusão das seguintes artérias pulmonares: SVD1 (artéria pulmonar esquerda; SVD2 (artéria pulmonar esquerda e do lobo inferior direito e SVD3 (artéria pulmonar esquerda, do lobo inferior direito e do lobo mediastinal, obstruindo a vasculatura pulmonar em 42, 76 e 82,0% respectivamente. Variáveis de hemodinâmica foram medidas a cada 15 minutos durante a uma hora do estudo. Na análise estatística, foram utilizados ajustes de modelos lineares mistos com estrutura de variâncias e covariâncias. RESULTADOS: Nas comparações intergrupais, houve aumento significativo da frequência cardíaca (p = 0,004, pressão arterial pulmonar média (p = 0,001 e pressão capilar pulmonar (p FUNDAMENTO: La sobrecarga ventricular derecha aguda está asociada a situaciones clínicas de elevada morbimortalidad, tales como: resecciones pulmonares extensas, tromboembolismo pulmonar, transplante pulmonar y edema pulmonar de las alturas. Algunos puntos de su fisiopatología permanecen obscuros. OBJETIVO:Evaluar los efectos hemodinámicos de la sobrecarga ventricular derecha aguda experimental en porcinos. MÉTODOS:La sobrecarga ventricular derecha fue inducida por la oclusión de las arterias pulmonares a través de ligaduras. Veinte cerdos fueron utilizados en

  20. ESR study on carboxymethyl chitosan radicals in an aqueous solution

    Saiki, Seiichi, E-mail: saiki.seiichi@jaea.go.j [Graduate School of Engineering, University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-8656 (Japan); Quantum Beam Science Directorate, Japan Atomic Energy Agency, 1233 Watanuki, Takasaki, Gunma 370-1292 (Japan); Nagasawa, Naotsugu; Hiroki, Akihiro; Morishita, Norio; Tamada, Masao [Quantum Beam Science Directorate, Japan Atomic Energy Agency, 1233 Watanuki, Takasaki, Gunma 370-1292 (Japan); Muroya, Yusa; Kudo, Hisaaki [Graduate School of Engineering, University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-8656 (Japan); Katsumura, Yosuke [Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-8656 (Japan); Advanced Science Research Center, Japan Atomic Energy Agency, 2-4 Shirakata-Shirane, Tokai, Naka, Ibaraki 319-1195 (Japan)

    2010-03-15

    Carboxymethyl chitosan (CMCTS) at a highly concentrated aqueous solution forms hydrogel by ionizing irradiation. To study on radiation-induced reaction mechanism of CMCTS in an aqueous solution, CMCTS radicals formed by reactions with OH radical were observed by ESR method. As a result of ESR spectral analysis, CMCTS radicals were identified as radicals on carboxymethyl groups.

  1. Hepatite aguda colestática pelo propiltiouracil: relato de caso Acute cholestatic hepatitis induced by propylthiouracil: case report

    Mônica Beatriz PAROLIN

    2000-04-01

    Full Text Available Propiltiouracil é uma droga amplamente utilizada no tratamento do hipertiroidismo. A hepatotoxicidade é um dos efeitos colaterais mais raros e também mais graves associados a ela. Relata-se um caso de hepatite aguda colestática que acomete um jovem de 15 anos em uso de propiltiouracil para tratamento de hipertiroidismo. Causas virais, metabólicas e autoimunes foram excluídas e a biopsia hepática revelou achados histopatológicos sugestivos de hepatite colestática induzida por droga. Com a suspensão da droga, houve remissão dos sintomas e normalização progressiva das provas de função hepática. Raramente, os pacientes em uso de propiltiouracil podem desenvolver injúria hepática grave.Propylthiouracil is widely used to treat patients with hyperthyroidism. However, propylthiouracil-induced hepatitis is an uncommon entity. The case of a 15-year-old boy treated with propylthiouracil for hyperthyroidism who developed a cholestatic acute hepatitis is reported. Viral, metabolic and autoimmune liver diseases were excluded and liver biopsy showed a pattern suggestive of drug-induced cholestatic hepatitis. After discontinuating the drug, there was a progressive resolution of symptoms and normalization of liver biochemical tests. Despite its rarity, patients receiving propylthiouracil are exposed to develop severe hepatotoxicity.

  2. Mecanismos del daño celular en la insuficiencia renal aguda Mechanisms of cell damage in acute renal failure

    José Martínez

    1989-01-01

    Full Text Available

    Los mecanismos del da no celular en la insuficiencia renal aguda Incluyen alteraciones en la producción de energía, la permeabilidad celular y el transporte de calcio. Dichas alteraciones producen cambios progresivos en la estructura celular que pueden ser reversibles si desaparece la causa que llevó a la falla renal, excepto cuando se alcanza la fase final de la lesión de la membrana y se llega a necrosis celular. Este mismo fenómeno probablemente ocurre tambIén en situaciones clínicas.

    The mechanisms of cellular damage In acute renal failure Include alterations In energy production, cell membrane permeability and calcium transport. These changes lead to progressive damage of the whole cellular structure which In general can be reversible If the precipitating cause disappears, except when the final stages of cell membrane lesion take place and cellular necrosis has occurred. This phenomenon probably applies for the clinical settling as well.

  3. Deleción terminal del brazo largo del cromosoma 9 en Leucemia promielocítica aguda

    Herrera JC.

    2001-06-01

    Full Text Available La Leucemia Promielocítica Aguda (LPA, definida como M3 en la clasificación francesa-americana- británica (FAB(1, se caracteriza por presentar una translocación cromosómica al azar t(15;17(q22;q21. En esta translocación se fusionan los receptores del ácido retinoíco ?(? RAR gen localizado en el cromosoma 17 y el gen PML sobre el cromosoma 15(2. Por otra lado, la deleción del brazo largo del cromosoma 9(9q- es una alteración rara específica encontrada en (LMA como una anormalidad única del cariotipo o como un cambio secundario, particularmente junto con t(8;21(q22;q22(3,4. La mayoría de ellas son deleciones intersticiales, 9q12 y 9q22; constituyen el sitio más común de ruptura proximal y distal (5.

  4. Oclusão arterial aguda por derivados da ergotamina Acute arterial occlusion caused by ergotamine derivatives

    Edison Barreto de Souza

    2009-09-01

    Full Text Available Os derivados da ergotamina compõem diversas drogas amplamente utilizadas no tratamento de ataques agudos de migrânea. A intoxicação por estas substâncias resulta geralmente de sua administração crônica, promovendo sintomas secundários ao espasmo arterial e à consequente isquemia distal. Neste artigo, é relatado o caso de uma paciente de 47 anos com diagnóstico de oclusão arterial aguda em membros inferiores secundária ao uso de derivados da ergotamina. Após a suspensão da droga e a prescrição de anticoagulantes, vasodilatadores e antiagregante plaquetário, a paciente evoluiu com melhora da dor, da parestesia e com o retorno da coloração normal e dos pulsos distais em membros inferiores.Ergotamine derivatives include several drugs widely used in the treatment of acute migraine attacks. Intoxication by these substances generally results from chronic administration, promoting symptoms secondary to arterial spasm and the consequent distal ischemia. The authors report the case of a 47-year old patient with acute arterial occlusion in lower limbs secondary to the use of ergotamine derivatives. After drugs were suspended and anticoagulants, vasodilators and antiplatelet drugs were prescribed, the patient progressed with improvement of pain, paresthesia and return of normal skin color and distal pulses in lower limbs.

  5. Alimentación sostenida durante diarrea aguda en niños menores de cinco años

    MARTÍNEZ-SALGADO HOMERO

    1998-01-01

    Full Text Available Objetivo. Identificar alimentos locales con aceptabilidad cultural para nutrir a niños con diarrea aguda y probar su aceptación e impacto sobre el peso corporal en niños enfermos. Material y métodos. Se entrevistó a 142 madres de niños menores de cinco años en comunidades rurales, para conformar dietas culturalmente aceptables mediante sorteo de grupos, desplegado en un diagrama multidimensional. Se hizo un ensayo sobre el curso clíniño de 54 niños de 4-50 meses de edad cursando las primeras 48 horas de un episodio diarreico, quienes recibieron las dietas desarrolladas. Resultados. Se diseñaron dietas de acuerdo con la edad del niño y con el tiempo de evolución de la enfermedad. En las 47.6 ± 22.2 horas que permanecieron hospitalizados, los niños consumieron 44.8 ± 28.6 kcal/kg/día (además de la leche materna y ganaron 70.6 ± 179.7 g. Hubo una relación directa entre mayor edad y mayor consumo calórico, y entre éste y mayor ganancia de peso. Conclusiones. Los niños mostraron buena aceptabilidad a las dietas ofrecidas, de tal manera que se evitó la pérdida de peso.

  6. Leucemia mieloide aguda versus ocupação profissional: perfil dos trabalhadores atendidos no Hospital de Hematologia de Recife

    Queliane Gomes da Silva Carvalho

    2011-12-01

    Full Text Available O estudo objetivou conhecer o perfil dos trabalhadores em faixa etária economicamente ativa admitidos de 1997 a 2007 em hospital de hematologia com diagnóstico de leucemia mieloide aguda (LMA; verificar as profissões com maior prevalência entre os trabalhadores atendidos que foram a óbito e identificar os riscos ocupacionais compatíveis com o aparecimento da LMA nas profissões prevalentes. Estudo exploratório de natureza quantitativa. A maior parte dos perfis caracterizou-se por ser procedente do agreste e da região metropolitana do estado, do sexo masculino, pertencente à raça branca e com grau de escolaridade fundamental incompleto. As ocupações de maior destaque foram aquelas relacionadas à agricultura e ao trabalho doméstico, sendo as substâncias químicas utilizadas no processo de trabalho de ambas, de acordo com a literatura, possíveis fatores envolvidos no desencadeamento da patologia.

  7. Modeling Radicalization Phenomena in Heterogeneous Populations.

    Galam, Serge; Javarone, Marco Alberto

    2016-01-01

    The phenomenon of radicalization is investigated within a mixed population composed of core and sensitive subpopulations. The latest includes first to third generation immigrants. Respective ways of life may be partially incompatible. In case of a conflict core agents behave as inflexible about the issue. In contrast, sensitive agents can decide either to live peacefully adjusting their way of life to the core one, or to oppose it with eventually joining violent activities. The interplay dynamics between peaceful and opponent sensitive agents is driven by pairwise interactions. These interactions occur both within the sensitive population and by mixing with core agents. The update process is monitored using a Lotka-Volterra-like Ordinary Differential Equation. Given an initial tiny minority of opponents that coexist with both inflexible and peaceful agents, we investigate implications on the emergence of radicalization. Opponents try to turn peaceful agents to opponents driving radicalization. However, inflexible core agents may step in to bring back opponents to a peaceful choice thus weakening the phenomenon. The required minimum individual core involvement to actually curb radicalization is calculated. It is found to be a function of both the majority or minority status of the sensitive subpopulation with respect to the core subpopulation and the degree of activeness of opponents. The results highlight the instrumental role core agents can have to hinder radicalization within the sensitive subpopulation. Some hints are outlined to favor novel public policies towards social integration. PMID:27166677

  8. Modeling Radicalization Phenomena in Heterogeneous Populations.

    Serge Galam

    Full Text Available The phenomenon of radicalization is investigated within a mixed population composed of core and sensitive subpopulations. The latest includes first to third generation immigrants. Respective ways of life may be partially incompatible. In case of a conflict core agents behave as inflexible about the issue. In contrast, sensitive agents can decide either to live peacefully adjusting their way of life to the core one, or to oppose it with eventually joining violent activities. The interplay dynamics between peaceful and opponent sensitive agents is driven by pairwise interactions. These interactions occur both within the sensitive population and by mixing with core agents. The update process is monitored using a Lotka-Volterra-like Ordinary Differential Equation. Given an initial tiny minority of opponents that coexist with both inflexible and peaceful agents, we investigate implications on the emergence of radicalization. Opponents try to turn peaceful agents to opponents driving radicalization. However, inflexible core agents may step in to bring back opponents to a peaceful choice thus weakening the phenomenon. The required minimum individual core involvement to actually curb radicalization is calculated. It is found to be a function of both the majority or minority status of the sensitive subpopulation with respect to the core subpopulation and the degree of activeness of opponents. The results highlight the instrumental role core agents can have to hinder radicalization within the sensitive subpopulation. Some hints are outlined to favor novel public policies towards social integration.

  9. Modeling Radicalization Phenomena in Heterogeneous Populations

    2016-01-01

    The phenomenon of radicalization is investigated within a mixed population composed of core and sensitive subpopulations. The latest includes first to third generation immigrants. Respective ways of life may be partially incompatible. In case of a conflict core agents behave as inflexible about the issue. In contrast, sensitive agents can decide either to live peacefully adjusting their way of life to the core one, or to oppose it with eventually joining violent activities. The interplay dynamics between peaceful and opponent sensitive agents is driven by pairwise interactions. These interactions occur both within the sensitive population and by mixing with core agents. The update process is monitored using a Lotka-Volterra-like Ordinary Differential Equation. Given an initial tiny minority of opponents that coexist with both inflexible and peaceful agents, we investigate implications on the emergence of radicalization. Opponents try to turn peaceful agents to opponents driving radicalization. However, inflexible core agents may step in to bring back opponents to a peaceful choice thus weakening the phenomenon. The required minimum individual core involvement to actually curb radicalization is calculated. It is found to be a function of both the majority or minority status of the sensitive subpopulation with respect to the core subpopulation and the degree of activeness of opponents. The results highlight the instrumental role core agents can have to hinder radicalization within the sensitive subpopulation. Some hints are outlined to favor novel public policies towards social integration. PMID:27166677

  10. Analysis of radicals induced in irradiated foods

    By electron spin resonance (ESR) spectroscopy, we revealed free radicals in γ-ray irradiated foods; black pepper, green coffee bean and ginseng. We also analyzed the decay behavior of radiation induced free radicals during storage of irradiated foods. The ESR spectrum of experimental irradiated foods consists of a sextet signal centered at g=2.0 and a singlet signal at the same g-value position and a singlet signal at g=4.0. The singlet signal at g=2.0 is originated from organic free radicals and its peak intensity showed the dependence of γ-ray irradiation dose levels. The signal intensity was decreased during storage. Only after 3 hours of radiation treatment the peak intensity was decreased fast and after that the intensity was decreased slowly. The relaxation times, T1 and T2, of radiation induced free radicals showed the variations before and after irradiation. During long time storage period it was shown that T1 was increased and T2 was decreased. By analysis of decay process using the simulation methods based on the theory of reaction speed, it is considered that at least two kinds of radicals were induced in irradiated foods during long time storage. (author)

  11. Tuning the Reactivity of Radical through a Triplet Diradical Cu(II) Intermediate in Radical Oxidative Cross-Coupling

    Zhou, Liangliang; Yi, Hong; Zhu, Lei; Qi, Xiaotian; Jiang, Hanpeng; Liu, Chao; Feng, Yuqi; Lan, Yu; Lei, Aiwen

    2015-11-01

    Highly selective radical/radical cross-coupling is paid more attention in bond formations. However, due to their intrinsic active properties, radical species are apt to achieve homo-coupling instead of cross-coupling, which makes the selective cross-coupling as a great challenge and almost untouched. Herein a notable strategy to accomplish direct radical/radical oxidative cross-coupling has been demonstrated, that is metal tuning a transient radical to a persistent radical intermediate followed by coupling with another transient radical. Here, a transient nitrogen-centered radical is tuned to a persistent radical complex by copper catalyst, followed by coupling with a transient allylic carbon-centered radical. Firstly, nitrogen-centered radical generated from N-methoxybenzamide stabilized by copper catalyst was successfully observed by EPR. Then DFT calculations revealed that a triplet diradical Cu(II) complex formed from the chelation N-methoxybenzamide nitrogen-centered radical to Cu(II) is a persistent radical species. Moreover, conceivable nitrogen-centered radical Cu(II) complex was observed by high-resolution electrospray ionization mass spectrometry (ESI-MS). Ultimately, various allylic amides derivatives were obtained in good yields by adopting this strategy, which might inspire a novel and promising landscape in radical chemistry.

  12. Free Radical Scavenging Activity of Leaves of Alocasia indica (Linn)

    Mulla, W. A.; Salunkhe, V. R.; Kuchekar, S. B.; Qureshi, M. N.

    2009-01-01

    The free radical scavenging potential of the plant Alocasia indica(Linn.) was studied by using different antioxidant models of screening like scavenging of 1,1-diphenyl-2-picryl hydrazyl radical, nitric oxide radical, superoxide anion radical, hydroxyl radical, iron chelating activity, total antioxidant capacity, non-enzymatic glycosylation of haemoglobin, rapid screening for antioxidant compounds by thin layer chromatography. The hydroalcoholic extract at 1000 μg/ml showed maximum scavenging...

  13. Formation of semiquinone radical anion and free radical scavenging reactions of plumbagin. A pulse radiolysis study

    Kinetics and mechanism of scavenging of reducing free radicals by plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) are studied using pulse radiolysis technique. It scavenged superoxide radical, hydroxyethyl radical and hydrated electron with bimolecular rate constants of 8.9 × 107, 2.3 × 109 and 1.6 × 1010 M-1 s-1, respectively in aqueous-alcohol medium. Plumbagin also scavenged linoleic acid peroxyl radical and tyrosyl radical with bimolecular rate constants of 1.0 × 108 and 7.0 × 106 M-1 s-1, respectively. Further, redox properties of plumbagin and its transients are studied using standard redox couples and cyclic voltammetry. (author)

  14. Isolation of Hypervalent Group-16 Radicals and Their Application in Organic-Radical Batteries.

    Imada, Yasuyuki; Nakano, Hideyuki; Furukawa, Ko; Kishi, Ryohei; Nakano, Masayoshi; Maruyama, Hitoshi; Nakamoto, Masaaki; Sekiguchi, Akira; Ogawa, Masahiro; Ohta, Toshiaki; Yamamoto, Yohsuke

    2016-01-20

    Using a newly prepared tridentate ligand, we isolated hypervalent sulfur and selenium radicals for the first time and characterized their structures. X-ray crystallography, electron spin resonance spectroscopy, and density functional theory calculations revealed a three-coordinate hypervalent structure. Utilizing the reversible redox reactions between hypervalent radicals and the corresponding anions bearing Li(+), we developed organic radical batteries with these compounds as cathode-active materials. Furthermore, an all-radical battery, with these compounds as the cathode and a silyl radical as the anode, was developed that exhibited a practical discharge potential of ∼ 1.8 V and stable cycle performance, demonstrating the potential of these materials for use in metal-free batteries that can replace conventional Li-ion batteries where Li is used in the metal form. PMID:26721786

  15. Radical kinetics and characterization of the free radicals in gamma irradiated red pepper

    Kinetic behaviors and characterization of the natural and γ-induced radicals in irradiated red pepper have been investigated by electron spin resonance (ESR) spectroscopy to explore the possibility of using this technique in detecting irradiated red pepper and to evaluate the eventual dosimetric features of this widely used food. Unirradiated samples exhibited a single resonance line centered at g=2.0050±0.0005. Photo-exposure of the samples was found to increase the signal intensity. An increase in temperature created a drastic decrease in the concentration of natural radicals responsible for the single resonance line. Irradiation was observed to induce increases in the intensity of single resonance line (signal I) and a radiation specific doublet and/or triplet (signal II) also centered at g=2.0050 but detectable only at high spectrometer gains. The intensities of both signals increased with increasing radiation dose. The signals I and II were found to decay with different rates depending on the temperature. The results of a fitting procedure applied to the experimental signal decay curves and those obtained from room temperature spectra simulation calculations were used together to determine radical species and their spectral characteristics giving rise to the observed experimental spectra. Four radical species, three carbohydrate and one semiquinone radical assigned as radicals A, B, C and D, respectively, were found to best explain the experimental results. All the radicals show large g and hyperfine splitting anisotropies varying between g=2.0028-2.0062 and 1.07-2.58 mT, respectively. The half lives of the radicals were found to depend strongly on temperature. The activation energy calculated using temperature dependent half-life data were the highest for radical A (33.68 kcal/mol) and smallest for radical C (11.83 kcal/mol)

  16. Free-radical chemistry of thiourea in aqueous solution, induced by OH radical, H atom, α-hydroxyalkyl radicals, photoexcited maleimide, and the solvated electron

    Hydroxyl radicals react with thiourea (and its tetramethyl derivative) yielding dimeric radical cations which are characterized by strong absorptions at 400 nm (450 nm). An analysis of the kinetics of the buildup of these absorptions gives evidence for the intermediacy of OH-adducts and the monomeric radical cations. The dimeric radical cations are also generated in the reactions of triplet-excited maleimide with those thioureas. Moreover, in acidic solutions even reducing radicals such as the H atom and α-hydroxy alkyl radicals give rise to these intermediates in full yields, albeit displaying different kinetics. Potential mechanistic implications are discussed. The dimeric thiourea radical cations are strong oxidants and readily oxidize the anions of phenol and 2'-deoxyguanosine. The solvated electron gives rise to an intermediate which is rapidly protonated by water (pKa > 11). Quantum mechanical calculations support the assignment of the 400 nm (450 nm) absorption to the respective dimeric thiourea radical cation. (author)

  17. Exploring how lead users develop radical innovation

    Lettl, Christopher; Gemuenden, Hans Georg; Hienerth, C.

    2008-01-01

    In this study, we explore how lead users develop radical innovations outside of manufacturing firms. We analyze the transition from a very early stage of activities to the ultimate commercialization of these innovations. The focus in this context is on the initiatives undertaken by lead users in...... lead users as surgeons launch entrepreneurial activities and bridge periods in which established medical equipment manufacturers would not risk investing in radical innovations. By doing so, lead users create the conditions usually provided in manufacturer-initiated lead user projects, including the...... supply of diversified knowledge, the development and coordination of a network for further development of the innovation, and initial tests of technical or market feasibility. Our findings have implications for manufacturing firms that wish to design radical innovation projects with (individual) lead...

  18. Radiation chemistry of aromatic dimer radical cations

    π-π Interactions of aromatic molecules are paid attention much in many fields, especially biology, chemistry, and applied physics, represented as protein, DNA, electron donor-accepter complexes, charge transfers, and self assembly molecules. Aromatic molecules including benzene rings are the simplest case to study the π-π interactions. To interpret the charge resonance (CR) structure in the dimer radical cations, spectroscopic and ESR methods have been carried out. The spectroscopic study on the dimer radical ion of molecules with two chromophores would be profitable to identify the electronic and configurational properties. In this article, dynamics of the dimer radical cation of benzenes, polystyrenes, and resist polymers is described on the basis of direct observation of CR band by the nanosecond pulse radiolysis and low temperature γ-radiolysis methods. (author)

  19. Radical abdominoplasty, including body shaping: representative cases.

    Mühlbauer, W

    1989-01-01

    Even in the age of liposuction there exist certain situations for which abdominoplasty in its radical form is indicated--for example, redundant skin after radical weight loss, the stigmata of postpregnancy syndrome, and localized accumulation of adipose tissue--the lipodystrophies and resistant generalized obesity. Redundant skin after radical weight loss is resected simultaneously around the abdomen, the lumbar regions, the perineum, and the thighs. The typical stigmata of postpregnancy syndrome may be excised through an extended abdominoplasty combined with simultaneous excision and pexy of the inner aspects of the thighs leaving a "bikini" scar behind. A mastopexy may be added. Genetically predisposed localized lipodystrophies in the abdominal lumbar, and upper thigh region may be resected through a circular abdominoplasty with or without simultaneous resection of the perineum and inner thighs. Abdominal aprons often contain umbilical or ventral hernias that may need to be repaired simultaneously. Representative cases are presented and dangers and complications are discussed. PMID:2741749

  20. Preparation and study of dialkyl nitroxide radicals

    These radicals are obtained by oxidation of N-hydroxy-imides with lead tetracetate or p-nitro-perbenzoic acid. These imides are prepared by heating dicarboxylic acids anhydrides with benzyloxy-amine followed by catalytic hydrogenation of N-benzyloxy-imides so obtained. Two series of radicals have mainly been studied, the first concerning five-membered cyclic imides, the second six-membered cyclic imides, these molecules having methyls substituents or no on the carbon ring. N. M. R. spectra of some O-benzyl-imides have been analysed. These different results have made it possible to study the conformation and stereochemistry of these imides. (author)

  1. Free Radicals in Adolescent Varicocele Testis

    Carmelo Romeo; Giuseppe Santoro

    2014-01-01

    We examine the relationship between the structure and function of the testis and the oxidative and nitrosative stress, determined by an excessive production of free radicals and/or decreased availability of antioxidant defenses, which occur in the testis of adolescents affected by varicocele. Moreover, the effects of surgical treatment on oxidative stress were provided. We conducted a PubMed and Medline search between 1980 and 2014 using “adolescent,” “varicocele,” “free radicals,” “oxidative...

  2. Free-radical kinetics of coal liquefaction

    Wang, M.; Smith, J.M.; McCoy, B.J.

    1994-07-16

    A rate expression with first- and second-order terms in the concentration of extractable compounds in solid coal particles is derived from a fundamental free-radical mechanism. The expression was suggested empirically by prior experiments for coal liquefaction in the presence of a hydrogen-donor solvent. Radical reactions are considered to occur in both coal and in solvent. The long-chain approximation justifies the neglect of initiation, hydrogen abstraction, and termination rates as quantitatively insignificant relative to propagation reaction rates.

  3. Resonance ionization detection of combustion radicals

    Cool, T.A. [Cornell Univ., Ithaca, NY (United States)

    1993-12-01

    Fundamental research on the combustion of halogenated organic compounds with emphasis on reaction pathways leading to the formation of chlorinated aromatic compounds and the development of continuous emission monitoring methods will assist in DOE efforts in the management and disposal of hazardous chemical wastes. Selective laser ionization techniques are used in this laboratory for the measurement of concentration profiles of radical intermediates in the combustion of chlorinated hydrocarbon flames. A new ultrasensitive detection technique, made possible with the advent of tunable VUV laser sources, enables the selective near-threshold photoionization of all radical intermediates in premixed hydrocarbon and chlorinated hydrocarbon flames.

  4. Resonant cavity spectroscopy of radical species

    Ritchie, Grant

    2015-04-01

    Photo-oxidation in the troposphere is highly complex, being initiated by short lived radical species, in the daytime dominated by the hydroxyl radical, OH, with contributions from Cl atoms, and at night by either NO3 radicals or ozone. Chemical oxidation cycles, which couple OH, HO2 and peroxy (RO2) radical species, remove primary emitted trace species which are harmful to humans or to the wider environment. However, many of the secondary products produced by atmospheric photo-oxidation are also directly harmful, for example O3, NO2, acidic and multifunctional species, many of which are of low volatility and are able to partition effectively to the condensed phase, creating secondary organic aerosol (SOA), which contributes a significant fraction of tropospheric aerosol, with associated impacts on climate and human health. The accuracy of atmospheric models to predict these impacts necessarily requires accurate knowledge of the chemical oxidative cycling. Two of the simplest intermediates are the hydroperoxy radical, HO2, and the smallest and dominant organic peroxy radical, CH3O2, formed directly by the reactions of OH with CO/O2 and CH4/O2, respectively, and indirectly following the oxidation of larger VOCs. OH, HO2 and RO2 (collectively known as ROx) are rapidly cycled, being at the centre of tropospheric oxidation, and hence are some of the best targets for models to compare with field data. The reaction of HO2 and RO2 with NO constitutes the only tropospheric in-situ source of O3. Despite their importance, neither HO2 nor CH3O2 is measured directly in the atmosphere. HO2 is only measured indirectly following its conversion to OH and CH3O2 is not measured at all. Typically only the sum of RO2 radicals is measured, making no distinction between different organic peroxy radicals. This contribution will detail recent studies using (i) optical feedback cavity enhanced absorption spectroscopy with both quantum and inter-band cascade lasers in the mid-IR, and (ii

  5. Utilidad de la determinación de parámetros de inflamación, estrés oxidativo y vitamina D como factores pronósticos en lactantes con bronquiolitis aguda

    Moreno Solís, Gloria María

    2014-01-01

    Introducción. La bronquiolitis aguda (BA) es la infección respiratoria aguda de las respiratorias inferiores más frecuente en los primeros años de la vida, constituyendo la principal causa de ingreso hospitalario en lactantes durante los meses de otoño-invierno. El virus respiratorio sincitial (VRS), como agente etiológico, ha infectado a prácticamente toda la población infantil a los 2 años de edad. En la mayoría se manifiesta sólo con afectación de las vías respiratorias s...

  6. Injúria renal aguda em unidade de terapia intensiva: estudo prospectivo sobre a incidência, fatores de risco e mortalidade Acute kidney injury in intensive care unit patients: a prospective study on incidence, risk factors and

    Daniela Ponce; Caroline de Pietro Franco Zorzenon; Nara Yamane dos Santos; Ubirajara Aparecido Teixeira; André Luís Balbi

    2011-01-01

    OBJETIVO: Comparar características clínicas e evolução de pacientes com e sem injúria renal aguda adquirida em unidade de terapia intensiva geral de um hospital universitário terciário e identificar fatores de risco associados ao desenvolvimento de injúria renal aguda e à mortalidade. MÉTODOS: Estudo prospectivo observacional com 564 pacientes acompanhados diariamente durante a internação em unidade de terapia intensiva geral do Hospital das Clínicas da Faculdade de Medicina de Botucatu por 2...

  7. Excesso de peso em crianças e adolescentes sobreviventes de leucemia linfoide aguda: estudo de coorte Excessive weight in children and adolescents surviving acute lymphoid leukemia: a cohort study

    Alves, João Guilherme B; Clarissa M. A. Pontes; Mecneide M. Lins

    2009-01-01

    A leucemia linfoide aguda (LLA) é a neoplasia maligna mais comum na infância. A taxa de cura é hoje em torno de 80% e entre os sobreviventes tem sido descrito um aumento de risco de obesidade. Entretanto, não há estudos sobre esse risco em países em desenvolvimento, especialmente naqueles que atravessam um momento de transição nutricional, como o Brasil. O objetivo do estudo foi verificar a frequência de excesso de peso em crianças e adolescentes sobreviventes de leucemia linfoide aguda. Foi ...

  8. Estado nutricional de crianças e adolescentes sobreviventes de leucemia linfoide aguda tratados em um Centro de Referência da Região Nordeste do Brasil

    Bianca Araújo de Oliveira; Mecneide Mendes Lins; Francisco Pedrosa; Poliana Coelho Cabral; Janine Maciel Barbosa

    2013-01-01

    OBJETIVO: Avaliar o estado nutricional e os fatores clínicos, laboratoriais e comportamentais associados ao excesso de peso em crianças e adolescentes sobreviventes de leucemia linfoide aguda, tratados em um centro de referência da Região Nordeste do Brasil. MÉTODOS: Estudo de série de casos com 30 sobreviventes de leucemia linfoide aguda. Entre os meses de março e setembro de 2011, foram coletados dados clínicos, comportamentais e laboratoriais. O diagnóstico antropométrico foi realizado em ...

  9. Presença de anticorpo anti-Lutheran B em paciente com leucemia linfóide aguda Anti-Lutheran B in a patient with acute lymphoblastic leukemia

    Maria do Rosário F. Roberti; Cristiane A. Tuma; Janeslane F. Maciel

    2007-01-01

    Leucemias agudas necessitam de suporte hemoterápico para serem tratadas adequadamente. A presença do anticorpo anti-Lutheran B e a alta freqüência do antígeno em nossa população dificulta o tratamento de doenças hematológicas que necessitam de suporte transfusional, tais como a leucemia linfóide aguda (LLA). Alternativas de tratamento hemoterápico são abordadas neste artigo. Descreve-se o caso de uma paciente com LLA e anticorpo anti-Lutheran B. A dificuldade em encontrar sangue compatível le...

  10. Características y resultado a largo plazo de pacientes mayores con leucemia promielocítica aguda tratados con esquemas terapéuticos basados en ATRA más antraciclinas

    Martínez Cuadrón, David

    2015-01-01

    La leucemia promielocítica aguda (LPA) es un subtipo de leucemia mieloide aguda que se diferencia por una morfología característica y la presencia de la t(15;17) y su correspondiente reordenamiento molecular PML/RARa. Clínicamente, no es infrecuente que se presente con coagulopatía, pudiendo ser la responsable de la muerte del paciente incluso antes del diagnóstico. No obstante, su buena respuesta al tratamiento con ácido holo-trans retinoico (ATRA) se ha traducido en una importante mejoría d...

  11. Conducta de Infecciones Respiratorias Agudas con/sin Neumonías en menores de 5 años del Centro de Salud “San Benito”, Abril-Junio del 2010

    Alfredo Chuca Tumiri; Jimena Choque Verduguez; Maria Julia Perez Terceros; Edson Escobar Melendres

    2011-01-01

    Se asume como Infección Respiratoria Aguda al conjunto de infecciones del aparato respiratorio causadas pormicroorganismos, con evolución menor a 15 días, donde la forma más común de presentación, es la RinofaringitisAguda Catarral; con la presencia de signos clínicos, los cuales pueden estar o no acompañados de fiebre y que enocasiones se complican con neumonía.El objetivo del presente trabajo es determinar cuál es la prevalencia y terapéutica de infecciones respiratoriasagudas con o sin neu...

  12. Tipo de lactancia y su relación con el patrón de crecimiento y frecuencia de infección respiratoria y enfermedad diarreica agudas

    R. Espinoza Zavala; P Ocampo-Barrio; J. Quiroz-Pérez

    2005-01-01

    Objetivo: Comparar el patrón de crecimiento ponderal, frecuencia de Infección respiratoria aguda (IRA) y enfermedad diarreica aguda (EDA) del lactante menor de acuerdo al tipo de lactancia. Diseño: Estudio descriptivo, transversal y comparativo. Material y Métodos: Muestra no probabilística por conveniencia que incluyó el total de niños atendidos por la Enfermera Materno Infantil en el primer semestre del año 2004. Se integraron a 116 lactantes menores de acuerdo al tipo de lactancia durante ...

  13. Acute pancreatitis associated with hypercalcemia: A report of two cases Pancreatitis aguda asociada a hipercalcemia: Presentación de dos casos

    J. Egea Valenzuela

    2009-01-01

    Full Text Available Hypercalcemia due to hyperparathyroidism is a rare etiology for acute pancreatitis, oscillating between 1.5 and 7% in the different series. Although the cause-effect relationship and the pathophysiology of the condition are not clear, it seems that the association among them is not incidental, and serum calcium could be a major risk factor, so that pancreatitis would come to occur during severe hypercalcemia attacks. Mutations in different genes have been proposed as well to justify why only some patients with primary hyperparathyroidism and hypercalcemia develop acute pancreatitis. References to cases like these ones are rare in the literature. We report two patients with acute pancreatitis associated with hyperparathyroidism and hypercalcemia, one of them with a fatal outcome.La hipercalcemia secundaria a hiperparatiroidismo es una causa rara de pancreatitis aguda, variando entre el 1,5-7% según las series consultadas. Aunque la relación causal y la fisiopatología del proceso no están totalmente aclaradas, parece claro que la asociación no es incidental y que los niveles de calcio sérico serían un factor de riesgo mayor, desencadenándose los cuadros de pancreatitis durante las crisis de hipercalcemia. También se han descrito alteraciones en diversos genes que podrían estar implicados, justificando por qué sólo unos pocos pacientes con hiperparatiroidismo primario e hipercalcemia sufren pancreatitis aguda. Existen muy pocas referencias en la literatura a casos como los que nos ocupan. Presentamos a continuación dos pacientes con cuadros de pancreatitis aguda asociados a hiperparatiroidismo e hipercalcemia, uno de ellos con desenlace fatal.

  14. Estudio de seguimiento a cinco años de la psicosis aguda: evolución diagnóstica y adaptación psicosocial

    A Pedrós Roselló

    2012-01-01

    Full Text Available Introducción: existe un grupo de psicosis agudas que presenta un pronóstico más favorable. Sin embargo, algunas de estas psicosis pueden evolucionar hacia enfermedades crónicas psicóticas o afectivas. El objetivo de este trabajo es el estudio de la evolución diagnóstica y pronóstico en psicosis aguda. Método. Estudio observacional durante cinco años de una muestra poblacional de pacientes con psicosis aguda. Resultados: a los cinco años el 73,2% de los 41 pacientes analizados recibe un diagnóstico de enfermedad psicótica o afectiva crónica, presentando mayor deterioro en su adaptación y calidad de vida. Aproximadamente un 50% de los casos con psicosis breve al inicio del estudio continúa manteniendo dicho diagnóstico. Aunque no existan diferencias en la evolución diagnóstica en relación al género, las mujeres presentan un menor grado de deterioro con una mejor adaptación. Conclusiones. A los cinco años la mayoría de los pacientes han desarrollado una enfermedad psicótica o afectiva crónica. El único diagnóstico con mayor estabilidady mejor pronóstico es el de trastorno psicótico breve, sobre todo con acontecimientos vitales desencadenantes. Las mujeres presentan un menor deterioro y mejor adaptación y calidad de vida que los hombres.

  15. Evaluación del sistema de vigilancia epidemiológica para la enfermedad diarreica aguda en el área rectora de salud de Alajuela 2

    Manrique Leal-Mateos

    2005-07-01

    Full Text Available Objetivo:El objetivo de este trabajo fue evaluar el sistema de vigilancia epidemiológica para la enfermedad diarreica aguda en el Área Rectora de Salud Alajuela 2 durante el mes de noviembre del año 2004,a .n de tener una apreciación detallada de su desempeño y utilidad. Métodos:Se utilizó la entrevista y observación como métodos directos de recolección de la información.Para esto,se aplicó al personal de salud del área rectora un cuestionario diseñado con base en los atributos cualitativos (simplicidad, flexibilidad,aceptabilidad y cuantitativos (sensibilidad,valor predictivo positivo,representatividad y oportunidad básicos que debe poseer un sistema de vigilancia epidemiológica. Es importante aclarar que durante las actividades realizadas se indagaron y comprobaron todos los aspectos necesarios para responder a las preguntas formuladas durante la evaluación. Resultados:Con base en los atributos evaluados se podría indicar que el sistema de vigilancia epidemiológica para la enfermedad diarreica aguda es relativamente sencillo y flexible.No obstante, existen problemas relacionados con los demás atributos que deben ser solucionados para obtener resultados más satisfactorios. Conclusiones:El presente trabajo demostró que el sistema de vigilancia epidemiológica para la enfermedad diarreica aguda necesita ciertos cambios en su planteamiento.Sin embargo,lejos de ser una debilidad,la identificación de ciertas deficiencias en el cumplimiento de algunos atributos como la sensibilidad,especificidad y oportunidad,debe servir como herramienta para perfeccionar el funcionamiento de éstos.

  16. Glutathione--hydroxyl radical interaction: a theoretical study on radical recognition process.

    Béla Fiser

    Full Text Available Non-reactive, comparative (2 × 1.2 μs molecular dynamics simulations were carried out to characterize the interactions between glutathione (GSH, host molecule and hydroxyl radical (OH(•, guest molecule. From this analysis, two distinct steps were identified in the recognition process of hydroxyl radical by glutathione: catching and steering, based on the interactions between the host-guest molecules. Over 78% of all interactions are related to the catching mechanism via complex formation between anionic carboxyl groups and the OH radical, hence both terminal residues of GSH serve as recognition sites. The glycine residue has an additional role in the recognition of OH radical, namely the steering. The flexibility of the Gly residue enables the formation of further interactions of other parts of glutathione (e.g. thiol, α- and β-carbons with the lone electron pair of the hydroxyl radical. Moreover, quantum chemical calculations were carried out on selected GSH/OH(• complexes and on appropriate GSH conformers to describe the energy profile of the recognition process. The relative enthalpy and the free energy changes of the radical recognition of the strongest complexes varied from -42.4 to -27.8 kJ/mol and from -21.3 to 9.8 kJ/mol, respectively. These complexes, containing two or more intermolecular interactions, would be the starting configurations for the hydrogen atom migration to quench the hydroxyl radical via different reaction channels.

  17. Radical scavenging ability of some compounds isolated from Piper cubeba towards free radicals.

    Aboul-Enein, Hassan Y; Kładna, Aleksandra; Kruk, Irena

    2011-01-01

    The purpose of this study was to identify the antioxidant activity of 16 compounds isolated from Piper cubeba (CNCs) through the extent of their capacities to scavenge free radicals, hydroxyl radical (HO(•)), superoxide anion radical O•(2)(-) and 2,2-diphenyl-1-picrylhydrazyl radical (DPPH(•)), in different systems. Electron paramagnetic resonance (EPR) and 5,5-dimethyl-1-pyrroline-N-oxide, DMPO, as the spin trap, and chemiluminescence techniques were applied. Using the Fenton-like reaction [Fe(II) + H(2)O(2)], CNCs were found to inhibit DMPO-OH radical formation ranging from 5 to 57% at 1.25 mmol L(-1) concentration. The examined CNCs also showed a high DPPH antiradical activity (ranging from 15 to 99% at 5 mmol L(-1) concentration). Furthermore, the results indicated that seven of the 16 tested compounds may catalyse the conversion of superoxide radicals generated in the potassium superoxide/18-crown-6 ether system, thus showing superoxide dismutase-like activity. The data obtained suggest that radical scavenging properties of CNCs might have potential application in many plant medicines. PMID:21681910

  18. Inactivation efficiencies of radical reactions with biologically active DNA

    Dilute aqueous solutions of biologically active ΦX174 DNA may serve as a simplified model system of the cell. Damage to the DNA after irradiation with γ-rays, may be ascribed to reactions with radical OH, radical H and esub(aq)- or secondary radicals, arising from reactions of water radicals with added scavengers. Conversion of primary (water) radicals into secondary (scavenger) radicals leads to a considerable protection of the DNA, which however, would have been larger if these secondary radicals did not contribute to DNA inactivation. The inactivation yield due to isopropanol or formate (secondary) radicals depends on dose rate as well as DNA concentration. Furthermore the inactivation efficiencies of the reactions of both the primary and the secondary radicals with single-stranded DNA could be established. (author)

  19. Nutrición artificial y pancreatitis aguda: revisión y actualización Artificial nutrition and acute pancreatitis: a review and update

    E. Gento Peña

    2007-02-01

    Full Text Available La mayoría de los casos de pancreatitis aguda se presentan como formas leves, en las que no se recomienda el soporte nutricional, a no ser que los pacientes no puedan reanudar su alimentación oral normal después de 5-7 días. Por el contrario, la pancreatitis grave cursa con estrés metabólico, y precisa de soporte nutricional precoz. En estos casos, se recomienda nutrición enteral, que debe complementarse con nutrición parenteral si es preciso. Estudios recientes indican que la nutrición enteral puede mejorar la evolución de la pancreatitis aguda grave, reducir las complicaciones y favorecer una recuperación más rápida de la enfermedad. La mayoría de los pacientes toleran una nutrición enteral oligomérica administrada en infusión continua distalmente al ángulo de Treitz. Estudios recientes apuntan, sin embargo, que la perfusión intragástrica es segura y puede ser una buena opción terapéutica en determinados pacientes con pancreatitis aguda grave. Además, agentes específicos añadidos a la nutrición (inmunomoduladores y probióticos parecen reducir la estancia hospitalaria y las complicaciones infecciosas y no infecciosas de la pancreatitis aguda.Most of acute pancreatitis cases present as mild cases for which nutritional support is not recommended provided the patient is able to restart normal oral intake within 5- days. By contrast, severe pancreatitis associates metabolic stress and requires early nutritional support. In these cases, enteral nutrition is recommended, which should be supplemented with parenteral nutrition if needed. Recent studies indicate that enteral nutrition may improve the course of severe acute pancreatitis, reduce its complications and promote a quicker improvement from the disease. Most of the patients tolerate oligomeric nutrition administered as continuous infusion distally to the Treitz’s angle. Recent studies show, however, that intragastric perfusion is safe and may be an adequate

  20. Insuficiência respiratória aguda durante anestesia pediátrica: atelectasia e pneumotórax hipertensivo: relato de caso

    Joel Massari Rezende; Bruno Ricciardi Silveira

    2012-01-01

    JUSTIFICATIVA E OBJETIVOS: A tarefa primordial do anestesiologista é garantir a adequada oxigenação do paciente. O objetivo deste relato é des crever o diagnóstico e conduta em um caso de insuficiência respiratória aguda durante anestesia, com finalidade didática. RELATO DO CASO: Criança de três anos submetida à anestesia para cirurgia urológica apresentou insuficiência respiratória por obstruções de brônquios por secreção, evoluindo com atelectasia e pneumotórax hipertensivo. Apresentamos o ...

  1. Expresión diferencial de reactantes de fase aguda en distintos tipos celulares de pacientes con enfermedad pulmonar obstructiva crónica

    Calero Acuña, Carmen

    2012-01-01

    La presente Tesis Doctoral se enmarca en el estudio de la enfermedad pulmonar obstructiva crónica (EPOC) como enfermedad pulmonar con repercusión sistémica y se basa en el estudio de la expresión celular diferencial de marcadores inflamatorios inespecíficos haciendo un especial hincapié en la importancia de los reactantes de fase aguda. Con objeto de centrar la exposición de la metodología y poder valorar adecuadamente los resultados, iniciaremos el presente trabajo realizando una revisión...

  2. Reducción de reactantes de fase aguda en mujeres con síndrome metabólico tras 12 semanas de entrenamiento

    Manuel Rosety-Rodríguez; Gabriel Fornieles; Alejandra Camacho-Molina; Ignacio Rosety; Antonio J. Díaz; Rosety, Miguel A.; Antonia Rodríguez-Pareja; Francisco J. Ordonez

    2013-01-01

    Fundamento y objetivo: Actualmente se acepta la importancia del estatus proinflamatorio en la fisiopatología del síndrome metabólico. De hecho, ha sido propuesto como diana terapéutica en el manejo clínico de estos pacientes. Por consiguiente este estudio pretende reducir los niveles plasmáticos de reactantes de fase aguda en mujeres con síndrome metabólico mediante un corto programa de entrenamiento. Material y método: Un total de 135 mujeres jóvenes adultas (38,4 ± 3,3 años) con diagnóstico...

  3. Trasplante de progenitores hematopoyéticos con acondicionamiento de intensidad reducida: aplicabilidad en leucemia mieloide aguda y síndromes mielodisplásicos

    Valcarcel Ferreiras, David

    2014-01-01

    El trasplante alogénico (Alo-TPH) es la única opción curativa en la mayoría de pacientes con leucemia mieloide aguda (LMA) y síndrome mielodisplásico (SMD) así como en otras enfermedades hematológicas neoplásicas y no neoplásicas. Sin embargo su aplicabilidad ha sido reducida por la toxicidad inherente al uso de dosis altas de quimioradioterapia utilizadas durante el acondicionamiento. El desarrollo de esquemas de acondicionamiento de menor intensidad, conocidos como acondicionamientos de int...

  4. Evaluación de la toxicidad aguda de un extracto de Boldoa purpurascens Cav. por el método de las clases

    Pérez, Maykel; Jiménez, Emilio E.; Boffill Cárdenas, María de los Ángeles; González, Dulce M.; Verdecia Machado, Belkys; Blanco Machado, Freisman

    2008-01-01

    Se realizó un estudio experimental con el objetivo de evaluar el posible efecto tóxico de un extracto acuoso liofilizado de Boldoa purpurascens Cav. (nitro blanco). Para el desarrollo del mismo se utilizó el Método de las Clases de Toxicidad Aguda (CTA), utilizando una dosis límite de 2000 mg/kg de peso corporal. Los animales seleccionados fueron ratas de la línea Sprague Dawley, con un peso comprendido entre 180 y 220 g. El peso corporal se comportó acorde a la curva de crecimiento de la ...

  5. Toxicidad aguda del cobre (Cu 2+ ) en postlarvas de camarón de río Cryphiops caementarius (Natantia, Palaemonidae)

    Raúl Mendoza-Rodríguez

    2013-01-01

    El presente trabajo evaluó la toxicidad del cobre sobre postlarvas de camarón de río Cryphiops caementarius mediante pruebas de toxicidad aguda, con el objetivo de determinar la concentración letal media (LC50-96). Los resultados refl ejaron que este estadío es muy sensible al cobre, en- contrando valores de LC50-96 de 0,546 mg.l-1. La sobrevivencia y la actividad natatoria fueron afectadas por el cobre, disminuyendo a medida que aumenta la concentración, encontrándose que las concentraciones...

  6. Comparação de critérios diagnósticos de insuficiência renal aguda em cirurgia cardíaca

    2013-01-01

    FUNDAMENTO: Há grande controvérsia quanto ao diagnóstico de Insuficiência Renal Aguda (IRA), existindo mais de 30 diferentes definições. OBJETIVO: Avaliar a incidência e os fatores de risco para desenvolvimento de IRA no pós-operatório de cirurgia cardíaca de acordo com os critérios RIFLE, AKIN e KDIGO, e comparar o poder prognóstico desses critérios. MÉTODOS: Estudo de corte transversal que incluiu 321 pacientes (62 [53 - 71] anos, 140 homens) consecutivamente submetidos a cirurgia cardíaca ...

  7. Infecções agudas das vias aéreas superiores: diagnóstico e tratamento ambulatorial Acute upper respiratory tract infections: outpatient diagnosis and treatment

    Paulo M.C. Pitrez

    2003-06-01

    Full Text Available OBJETIVO: apresentar uma revisão atualizada sobre as infecções das vias aéreas superiores (IVAS mais comuns na prática diária de consultório do pediatra, visando a uma adequada orientação de condutas diagnósticas e terapêuticas. FONTES DOS DADOS: foram revisadas referências obtidas na base de dados Medline. Foram selecionados os artigos mais relevantes sobre o tema. SÍNTESE DOS DADOS: rinofaringite aguda, sinusite aguda, faringoamigdalite aguda estreptocócica e laringite viral aguda são apresentadas de forma crítica e sucinta. As dificuldades observadas na prática clínica, em relação ao diagnóstico diferencial de determinadas IVAS, limitações na busca do agente etiológico e o uso, muitas vezes abusivo, de antimicrobianos são analisados e discutidos. CONCLUSÕES: as IVAS são um dos motivos mais comuns de visita ao consultório do pediatra. Por isso, conceitos e informações atualizados são essenciais para que o manejo dessa doença seja otimizado, reduzindo a indicação de exames diagnósticos dispensáveis, ou a implementação de tratamentos desnecessários ou prejudiciais ao paciente.OBJECTIVE: to present an updated review of the most common upper respiratory infections (URI in children seen by the pediatrician in outpatient clinics, for better diagnostic and therapeutic decisions. SOURCES OF DATA: references from Medline database were reviewed. The most relevant articles were selected. SUMMARY OF THE FINDINGS: acute rhinopharyngitis, sinusitis, streptococcal tonsillitis and viral croup are presented in a concise and critical view. Differential and etiological diagnosis limitations and the abusive use of antimicrobials in these illnesses are also discussed. CONCLUSIONS: URI are the most common cause of visits to pediatrician clinics. Therefore, update and critical concepts, as well as references are essential for a proper management of these illnesses, decreasing the indication of unnecessary diagnostic tests and

  8. Ventilación no invasiva mediante ventilador volumétrico convencional en la insuficiencia respiratoria aguda pediátrica.

    Flor Macián, Eva Mª

    2009-01-01

    RESUMEN La Insuficiencia respiratoria aguda (IRA) constituye una de las principales causas de ingreso en las UCIPs. La ventilación no invasiva (VNI), es decir, sin intubación endotraqueal ni traqueostomía, supone una alternativa a considerar en el tratamiento de estos pacientes. Existen numerosos estudios publicados sobre su eficacia en pacientes adultos con IRA para evitar la intubación y reducir la mortalidad. Sin embargo, su papel en la IRA pediátrica todavía no está bien definido. ...

  9. Dilatación gástrica aguda en una paciente bulímica: Repercusión sistémica

    Á. Franco-López; Badillo, S.; Contreras, J.

    2012-01-01

    Objetivos: Mostrar mediante un caso clínico, la repercusión sistémica y las complicaciones orgánicas, que pueden darse tras una dilatación gástrica aguda, ocasionada por un atracón bulímico. Caso clínico: Mujer joven, diagnosticada de bulimia nerviosa, acude a urgencias tras un atracón. A su llegada, presenta gran distensión abdominal y refiere dificultad para provocarse el vómito. Con el paso de unas horas, comienza a presentar signos de inestabilidad hemodinámica y oliguria. Se realiza un T...

  10. Indicación de la fisioterapia respiratoria convencional en la bronquiolitis aguda Indications of conventional chest physiotherapy in acute bronchiolitis

    Liliana Bohé; María Elisa Ferrero; Eduardo Cuestas; Laura Polliotto; Mariza Genoff

    2004-01-01

    Los objetivos de este trabajo fueron evaluar la utilidad de la fisioterapia respiratoria convencional en el tratamiento de la bronquiolitis aguda y determinar su influencia sobre los días de hospitalización. Se realizó un ensayo clínico controlado aleatorizado, donde se incluyeron dieciseis pacientes con bronquiolitis que fueron tratados dos veces al día con fisioterapia torácica y se compararon con dieciséis pacientes control, con la misma patología, quienes recibían sólo aspiración nasofarí...

  11. Lactancia materna y diarrea aguda en los primeros tres meses de vida Breast feeding and the incidence of acute diarrhea during the first three months of life

    Claudia Macías-Carrillo; Francisco Franco-Marina; Kurt Long-Dunlap; Sendy Isarel Hernández-Gaytán; Yolanda Martínez-López; Malaquías López-Cervantes

    2005-01-01

    OBJETIVO: Evaluar el efecto de la lactancia materna exclusiva y sus interacciones con algunos factores socioeconómicos, en relación con la incidencia de diarrea aguda durante los primeros tres meses de la vida. MATERIAL Y MÉTODOS: En la ciudad de Durango, México, en 1994 se llevó a cabo un estudio de cohorte con tres meses de seguimiento; la muestra estuvo compuesta por 327 parejas de madre y recién nacido, residentes de la ciudad de Durango, durante el periodo abril-junio de 1994. Para el an...

  12. Endoftalmitis aguda posterior a cirugía de catarata:resultados de un protocolo de diagnóstico y tratamiento

    Ramos López, Meisy

    2011-01-01

    Se realizó un estudio observacional analítico de cohorte retrospectiva de individuos operados de catarata en el período de los años 2000 -2009 en el Instituto Cubano de Oftalmología “Ramón Pando Ferrer”. El propósito de este estudio fue describir la incidencia de Endoftalmitis aguda postoperatoria de catarata en dos períodos: 2000-2007, con tratamientos a criterios del oftalmólogo de asistencia y posterior al 2008 con aplicación de un protocolo de diagnóstico y tratamiento diseñado y validado...

  13. Antitrombóticos nas síndromes coronarianas agudas: diretrizes atuais e novas evidências Antithrombotics in acute coronary syndromes: actual guidelines and new evidences

    Luiz Eduardo Fonteles Ritt; Uri Prync Flato; Hélio Penna Guimarães; Álvaro Avezum; Leopoldo Soares Piegas

    2008-01-01

    JUSTIFICATIVA E OBJETIVOS: As s��ndromes coronarianas agudas (SCA) estão entre as principais causas de admissão em unidades de terapia intensiva (UTI). Novos fármacos vêem sendo desenvolvidos para o manuseio das SCA. O uso combinado destes medicamentos tem reduzido de forma considerável a morbimortalidade desta síndrome, no entanto seus efeitos adversos ou mesmo seu manuseio incorreto podem levar à maior incidência de sangramento. O objetivo deste estudo foi apresentar os principais aspectos ...

  14. FLT3 y NPM1 como marcadores moleculares en la leucemia mieloblástica aguda. Utilidad pronóstica y diagnóstica.

    Pajuelo Gámez, Juan Carlos

    2015-01-01

    La Leucemia Mieloblástica Aguda (LMA) es una neoplasia clonal del tejido hematopoyético caracterizada por la proliferación de células blásticas anormales de estirpe mieloide en la médula ósea. El conocimiento de las alteraciones genéticas en la LMA, principalmente translocaciones cromosómicas, ha permitido establecer grupos de riesgo y conocer el pronóstico de los mismos. Sin embargo, existe una importante proporción de pacientes, en torno al 40-50%, que no pueden ser estratificados en base a...

  15. Composição química, atividade antibacteriana e avaliação da toxicidade aguda de vetiveria zizanoides L. Nash (Poaceae)

    Barros, Gilvana C.; Tresvenzol, Leonice M.F.; Cunha, Luiz C.; Pedro H. Ferri; José R. Paula; Bara, María Teresa. F.

    2009-01-01

    O vetiver (Vetiveria zizanioides L. Nash) é uma planta aromática representante da família Poaceae e utilizada na terapia Ayurvédica. Nesse trabalho objetivou-se investigar a composição química do óleo essencial da raiz do vetiver cultivado no Hospital de Medicina Alternativa em Goiás-Brasil, avaliar seu potencial antimicrobiano e realizar ensaio de toxicidade aguda. A análise química do óleo essencial foi realizada por cromatografia gasosa acoplada a espectrometria de massas (CG/EM), e o khus...

  16. Pancreatitis aguda necrotizante en una intoxicación fatal por metadona Acute necrotizing pancreatitis in a fatal poisoning with methadone

    A. Sibón; Ballesteros, S.; Martínez, M C

    2004-01-01

    La pancreatitis necrotizante es una causa infrecuente de muerte súbita. La metadona, un fármaco empleado en el tratamiento sustitutivo de adictos a opiáceos, ha sido responsable de muertes tras su ingestión accidental por niños cuando estaba a su alcance, en intentos autolíticos o después de un período de abstinencia en pacientes con tolerancia. La muerte se debe a depresión del sistema nervioso central y depresión respiratoria. Reportamos un caso de muerte súbita con pancreatitis aguda necro...

  17. Asociación de encefalomielitis diseminada aguda y síndrome de Guillain-Barré en un adulto

    Miguel A. Pagano; Alberto Allievi; Sebastián A. Muñoz; Verónica Marroquín; Milton Biaggioni; Lucas F. Vallejos

    2011-01-01

    La encefalomielitis diseminada aguda (EMDA) y el síndrome de Guillain-Barré (SGB) son reconocidas como entidades distintas, que afectan diferentes sectores del sistema nervioso, pero que comparten varias características tales como la patogenia autoinmune, el impacto sobre la mielina y el antecedente de infección viral o vacunación una a cuatro semanas previas al cuadro clínico. Se presenta un paciente varón de 41 años de edad que consultó por presentar fiebre, debilidad en miembros inferiores...

  18. Inmunofenotipaje celular en el diagnóstico de las leucemias agudas híbridas Cellular immunophenotyping in the diagnosis of acute hybrid leukemias

    Vianed Marsán Suárez

    1999-12-01

    Full Text Available Se estudiaron 118 leucemias agudas en un período de 4 años. El fenotipaje celular se realizó a través del ultramicrométodo inmunocitoquímico (UMICIQ, mediante la utilización de un panel de anticuerpos monoclonales con el que se evaluó la expresión de antígenos linfoides y mieloides. La expresión de antígenos mieloides en pacientes con leucemia linfoide aguda se encontró en el 28,4 % y de antígenos linfoides en pacientes con leucemia mieloide aguda en el 56,7 %. Las leucemias agudas híbridas representaron el 16,1 % del total de pacientes estudiados: 73,7 % al inicio de la enfermedad y el 26,3 % restante en el estudio posterior al tratamiento de inducción de la remisión, lo que sugiere en estos últimos la posibilidad de cambio de linaje por la selección de variantes resistentes a drogas procedentes del clon original, o la aparición de neoplasias secundarias por el uso de drogas genotóxicas118 acute leukemias were studied during 4 years. The cellular phenotyping was carried out through the immunocytochemical ultramicromethod by using a panel of monoclonal antibodies with which the expression of lymphoid and myeloid antigens was evaluated. The expression of myeloid antigens in patients with acute lymphoid leukemia was found in 28.4 %, whereas the expression of lymphoid antigens in patients suffering from acute myeloid leukemia was observed in 56.7 %. The acute hybrid leukemias accounted for 16.1 % of the total of patients studied: 73.7 % at the onset of the disease and the other 26.3 % in the study following the induction treatment of the referred patients, which suggests in the latter the possibility of changing lineage by selecting variantes resistant to drugs from the original clon, or the appearance of secondary neoplasias due to the use of genotoxic drugs

  19. Factores predictores de mediastinitis aguda en cirugía cardiovascular, protocolo de prevención y algoritmos diagnostico y terapéutico

    Machín Rodríguez, Jorge Carlos

    2013-01-01

    Se efectuó una investigación con el objetivo de identificar los factores predictores de mediastinitis aguda posoperatoria y describir los resultados de la aplicación del protocolo de prevención y de los algoritmos para su diagnóstico y terapéutica en el Cardiocentro de Santiago de Cuba; esta incluyó tres diseños metodológicos: uno para caracterizar a los pacientes con infección mediastínica, una investigación de casos y controles para determinar los factores predictores de esta complicación y...

  20. Optimización de la mecánica respiratoria en el tratamiento de soporte ventilatorio de pacientes con insuficiencia respiratoria aguda grave

    Morán Chorro, Indalecio

    2013-01-01

    Esta tesis se articula como compendio de publicaciones. En ella se incluyen tres estudios originales y una revisión que se enmarcan en una misma línea de investigación clínica enfocada a analizar la implementación de diferentes estrategias durante la ventilación mecánica invasiva de pacientes con insuficiencia respiratoria aguda grave. Las maniobras estudiadas se han dirigido a la optimización individual de los parámetros ventilatorios, a la mejora del intercambio de gases y a la minimización...

  1. Atividade antimicrobiana in vitro de produtos vegetais em otite externa aguda In vitro antimicrobial activity of plants in Acute Otitis Externa

    Janaina Cândida Rodrigues Nogueira; Margareth de Fátima Melo Diniz; Edeltrudes de O. Lima

    2008-01-01

    Otite externa aguda é a inflamação do conduto auditivo externo, e plantas medicinais podem ser utilizadas, na cultura popular, para seu tratamento. OBJETIVO: Avaliar atividade antimicrobiana in vitro de Aleolanthus suaveolens, Caryophyllus aromaticus, Cymbopogon citratus, Matricaria chamomila, Pithecellobium avaremotemo, Plectranthus amboinicus e Ruta graveolens sobre agentes etiológicos de otite externa. CASUÍSTICA E MÉTODOS: A concentração inibitória mínima de extratos e óleos destas planta...

  2. Inmunofenotipos aberrantes en leucemias agudas en una población hospitalaria de Buenos Aires Aberrant immunophenotypes in acute leukemia in a Buenos Aires' hospital population

    Viviana Novoa; Neri A. Núñez; Orlando G. Carballo; Carmen F. Lessa

    2013-01-01

    La citometría de flujo multiparamétrica es el método de elección para la caracterización inmunofenotípica de las células hematopoyéticas clonales presentes en los distintos procesos leucémicos agudos. El objetivo fue analizar la expresión de antígenos de membrana y evaluar la presencia de fenotipos aberrantes en los blastos de pacientes con diagnóstico de leucemia aguda, que permiten el monitoreo de la respuesta al tratamiento. Se revisaron los inmunofenotipos de 364 muestras de pacientes adu...

  3. Factores socioeconómicos que inciden en el abandono del tratamiento médico por pacientes pediátricos con leucemia aguda

    Isaac Otero, Gabriela; Instituto Nacional de Pediatría; Méndez Venegas, José; Instituto Nacional de Pediatría; Mora Magaña, Ignacio; Instituto Nacional de Pediatría; Leal Leal, Carlos; Instituto Nacional de Pediatría

    2013-01-01

    El objetivo del presente estudio fue describir la frecuencia de abandono del tratamiento médico por leucemia aguda por pacientes pediátricos sobre la base de características psicosociales y estadio de la enfermedad. Para ello, se revisaron 134 expedientes clínicos de aquellos pacientes atendidos a lo largo de cinco años. Los resultados muestran un índice de abandono de casi una cuarta parte. El nivel socioeconómico resultó significativo para dicho abandono del tratamiento, siendo la pobreza e...

  4. Quimioterapia intensiva en niños con leucemia linfoblástica aguda. Análisis ínterin en un centro de referencia en Colombia

    Trujillo Gaviria, Ángela María

    2015-01-01

    Antecedentes: La leucemia linfoide aguda es el cáncer más frecuente en los niños. La sobrevida está alrededor de 80% en países desarrollados. En países de bajos ingresos hay menor curación, probablemente por altas tasas de recaída, abandono de tratamiento y muerte relacionada con el tratamiento. Objetivo: Hacer una evaluación ínterin de muerte en inducción y relacionada con el tratamiento, recaídas, abandonos de tratamiento, describir la toxicidad más frecuentemente observada y evaluar la sob...

  5. Avaliação de biomarcadores em vertebrados aquáticos face à exposição aguda de cobre no meio

    Monteiro, Evanildo Tavares

    2012-01-01

    Em dezembro de 2009 ocorreu o colapso das escombreiras das minas do Portelo, tendo sido incorporado uma grande quantidade de sedimentos na rede hídrica e detectadas concentrações elevadas de metais pesados, em especial de cobre (Cu). No presente estudo foi feita a avaliação de biomarcadores em vertebrados aquáticos face à exposição aguda de cobre no meio aquático, tendo sido selecionados indicadores bioquímicos (e.g. concentrações de Na+ e K+ plasmático). Escolheu-se uma espéci...

  6. Evolución de la Mortalidad por Reacción Aguda tras consumo de Drogas en Galicia (1997‐2011)

    Miguel Arias, Domingo

    2015-01-01

    Resumen: Se estudian todos los sujetos fallecidos en Galicia por reacción aguda tras consumo de drogas (RAD) en los que existe intervención judicial a lo largo del periodo 1997-2011, según los criterios establecidos por el Plan Nacional sobre Drogas para todo el territorio nacional. Se recogieron y analizaron variables sociodemográficas, clínicas y toxicológicas de cada uno de los casos. El objetivo fundamental es tratar de determinar los principales factores de riesgo y/o perfil de las po...

  7. Implicaciones en la salud humana de la gastroenteritis aguda por norovirus como producto de la contaminación hídrica

    Brenda Delgadillo Espinoza; Cristian Moreira Segura; Freddy Araya Rodríguez

    2011-01-01

    En julio del 2010, un brote de gastroenteritis Aguda surgió entre los residentes de la ciudad principal de la Región Norte de Costa Rica: Ciudad Quesada. Esta investigación se llevó a cabo para explorar y caracterizar el brote en esa zona rural. Los datos de vigilancia y los registros médicos de los pacientes fueron analizados para elaborar un estudio descriptivo entre el 08 de julio y 14 de julio del 2010 en el Cantón de San Carlos. Una hoja de datos (Ficha Colectiva de Investigación VE 0.2)...

  8. Síndrome de Guillain-Barré associada a pancreatite aguda: relato de caso Guillain-Barré syndrome associated with acute pancreatitis: case report

    ANDERSON KUNTZ GRZESIUK; LUIZ AUGUSTO DOS SANTOS

    1999-01-01

    Relatamos um caso clínico de síndrome de Guillain-Barré associada a pancreatite aguda, e realizamos revisão na literatura sobre complicações clínicas relacionadas à síndrome de Guillain- Barré. Sugerimos estarem os eventos clínicos relacionados imunologicamente.We report a clinical case of Guillain-Barré syndrome associated with acute pancreatitis, and perform a review in literature about clinical complications related to Guillain-Barré syndrome. We suggest the possibility of being the events...

  9. Lesão renal aguda por glicerol: efeito antioxidante da Vitis vinifera L Acute kidney injury by glycerol: antioxidant effect of Vitis vinifera L

    Elisabete Cristina de Oliveira Martim; Carolina Ferreira Pinto; Mirian Watanabe; Maria de Fátima Fernandes Vattimo

    2007-01-01

    JUSTIFICATIVA E OBJETIVOS: A lesão renal aguda (LRA) é a complicação mais grave da rabdomiólise. Nessa síndrome, a liberação do pigmento heme desencadeia uma lesão que se caracteriza por vasoconstrição glomerular e toxicidade celular direta com provável componente oxidante. A renoproteção com antioxidantes tem demonstrado efeito satisfatório. As proantocianidinas são antioxidantes naturais encontradas no extrato da semente da uva. O objetivo deste estudo foi avaliar o efeito antioxidante da V...

  10. Respuesta inflamatoria de la Célula Acinar a diferentes lípidos generados en grasa necrotica durante la pancreatitit aguda

    Mateu Rico, Alberto

    2016-01-01

    [ES] La pancreatitis aguda (PA) es una enfermedad inflamatoria del páncreas en la que tiene lugar la secreción anormal al intersticio pancreático de enzimas digestivas como lipasas y fosfolipasas. Durante la PA se liberan grandes cantidades de ácidos grasos (AGs) y fosfolípidos (FLs) desde grasa peripancreática, habiéndose demostrado su capacidad para modular la respuesta inflamatoria. Como resultado del daño inicial del páncreas, se produce un reclutamiento masivo de leucocitos hacia la glán...

  11. Reflexões acerca da crioterapia na fase aguda da artrite reumatóide e suas correlações com a crioglobulinemia

    Dahyan Wagner da Silva Silveira; Eduardo Nagib Boery; Rita Narriman Silva de Oliveira Boery

    2006-01-01

    Artrite Reumatóide é uma doença sistêmica, caracterizada por um quadro inflamatório crônico com sinovite poliarticular persistente, de etiologia desconhecida e com grande potencial deformante. A imunoglobulina alterada é encontrada na maioria dos portadores, o que aumenta a probabilidade do paciente produzir crioglobulinas e desenvolver vasculite crioglobulinêmica. O objetivo deste estudo é analisar a indicação e a utilização da crioterapia no tratamento da fase aguda da Artrite Reumatóide e ...

  12. Orbital abscess secondary to acute dacryocystitis: case report Abscesso orbitário secundário à dacriocistite aguda: relato de caso

    Marcia Clivati Martins; José Reinaldo da Silva Ricardo; Patrícia Mitiko Santello Akaishi; Antonio Augusto Velasco e Cruz

    2008-01-01

    Acute dacryocystitis usually induces preseptal infection. In rare instances the infection that is confined to the lacrimal sac can extend to the orbital contents resulting in orbital cellulitis. We present a case of intraconal abscess secondary to acute dacryocystitis and review the literature of orbital cellulitis resulting from acute lacrimal sac infection.A dacriocistite aguda comumente evolui para infecção pré-septal. Raramente a infecção localizada no saco lacrimal pode estender-se ao co...

  13. Preditores de injúria renal aguda em pacientes submetidos ao transplante ortotópico de fígado convencional sem desvio venovenoso Predictors of acute kidney injury in patients undergoing a conventional orthotopic liver transplant without veno-venous bypass

    Olival Cirilo L. da Fonseca-Neto

    2011-06-01

    Full Text Available RADICAL: Injúria renal aguda é uma das complicações mais comuns do transplante ortotópico de fígado. A ausência de critério universal para sua definição nestas condições dificulta as comparações entre os estudos. A técnica convencional para o transplante consiste na excisão total da veia cava inferior retro-hepática durante a hepatectomia nativa. Controvérsias sobre o efeito da técnica convencional sem desvio venovenoso na função renal continuam. OBJETIVO: Estimar a incidência e os fatores de risco de injúria renal aguda entre os receptores de transplante ortotópico de fígado convencional sem desvio venovenoso. MÉTODOS: Foram avaliados 375 pacientes submetidos a transplante ortotópico de fígado. Foram analisadas as variáveis pré, intra e pós-operatórias em 153 pacientes submetidos a transplante ortotópico de fígado convencional sem desvio venovenoso. O critério para a injúria renal aguda foi valor da creatinina sérica > 1,5 mg/dl ou débito urinário BACKGROUND: Acute kidney injury is one of the most common complications of orthotopic liver transplantation. The absence of universal criteria for definition of these conditions make comparisons difficult between studies. The conventional technique for transplantation is the total excision of the inferior vena cava during liver retro-native hepatectomy. Controversies about the effect of the conventional technique without venovenous bypass on renal function remain. AIM: To estimate the incidence and risk of acute kidney injury factors among recipients of orthotopic liver transplantation without conventional venovenous bypass. METHODS: Was studied 375 patients undergoing orthotopic liver transplantation. Variables were analyzed in preoperative, intraoperative and postoperative complications in 153 patients undergoing orthotopic liver transplantation without conventional venovenous bypass. The criterion for acute kidney injury was serum creatinine > 1.5 mg/dl or

  14. Lesión pulmonar aguda producida por transfusión Transfusion-related acute lung injury

    J.M. Añón

    2010-03-01

    Full Text Available El término TRALI (transfusion related acute lung injury "lesión pulmonar aguda producida por transfusión" fue acuñado en 1985. Es un síndrome clínico relativamente raro, que puede constituir una amenza para la vida y que se caracteriza por insuficiencia respiratoria aguda y edema pulmonar no cardiogénico durante o después de una transfusión de productos hemáticos. Aunque su verdadera incidencia es desconocida se le ha atribuido un caso por cada 5.000 transfusiones de cualquier producto hemático y ha sido la causa más frecuente de muerte relacionada con la transfusión durante 3 años en Estados Unidos. Se han propuesto 2 etiologías. La primera es un episodio mediado por anticuerpos debido a la transfusión de anticuerpos contra el antígeno leucocitario o anticuerpos antigranulocito a pacientes cuyos leucocitos presentan antígenos afines. La segunda es un modelo en el que se precisan 2 eventos: el primero está relacionado con el cuadro clínico del receptor (sepsis, trauma, etc. que produce activación endotelial y secuestro de neutrófilos, y el segundo es la transfusión de sustancias con capacidad de modificar la respuesta biológica que activa los leucocitos adheridos que produce daño endotelial y aumento de permeabilidad capilar. El tratamiento es de soporte en función de la gravedad del cuadro clínico, y la prevención se centra en 3 estrategias: selección de donantes, actuación sobre el almacenamiento de los productos hemáticos y evitar las transfusiones innecesarias.The term Transfusion-Related Acute Lung Injury (TRALI was coined in 1985. It is a relatively rare, life-threatening clinical syndrome characterized by acute respiratory failure and non-cardiogenic pulmonary edema during or following a blood transfusion. Although its true incidence is unknown, a rate 1 out of every 5000 transfusions has been quoted. TRALI has been the most common cause of transfusion-related fatalities during three years in the USA. Two

  15. Radical recombinations in acetylene-air flames

    Zeegers, P.J.Th.; Alkemade, C.T.J.

    1965-01-01

    In this paper an analysis is given of the behaviour of excess radical concentrations, H, OH and O as a function of height above the reaction zone in premixed acetylene-air flames at 2–200° to 2400°K and 1 atmosphere pressure. The intensity was measured of the Li resonance line which is related to th

  16. Free-radical inactivation of muscle aldolase

    Rabbit muscle aldolase has been shown to be deactivated by addition of irradiated crystals of various sugars and amino acids. Inactivation observed immediately upon dissolution is ascribed to reaction with free radicals, whereas post-dissolution inactivation is ascribed to acid-catalyzed reaction with nonradical radiolysis products. (U.S.)

  17. Lipophilic fluorescent products of free radicals

    Ivica, Josko; Wilhelm, Jiří

    2014-01-01

    Roč. 158, č. 3 (2014), s. 365-372. ISSN 1213-8118 R&D Projects: GA ČR(CZ) GAP303/11/0298 Institutional support: RVO:67985823 Keywords : lipofuscin-like pigments * lipid peroxidation * free radicals * fluorescence Subject RIV: CE - Biochemistry Impact factor: 1.200, year: 2014

  18. Discourses of postmodern epistemology: Radical impetus lost?

    Mueller, Martin

    2006-01-01

    Exhibiting a highly divisive agenda postmodernism has created profound chasms across scientific communities. In development studies its radical impetus has translated into the postdevelopment perspective which violently repudiates the modernist development project. This paper crystallises two distinct discourses of working upon the epistemological raw material of postmodernism: an exclusivist discourse, which reinforces the chasm by isolating postmodernism, and an inclusivist discourse, which...

  19. Identity and Islamic Radicalization in Western Europe

    S.M. Murshed (Syed); S. Pavan (Sara)

    2009-01-01

    textabstractThis paper argues that both socio-economic disadvantage and political factors, such as the West’s foreign policy with regard to the Muslim world, along with historical grievances, play a part in the development of Islamic radicalized collective action in Western Europe. We emphasise the

  20. Designed metalloprotein stabilizes a semiquinone radical.

    Ulas, Gözde; Lemmin, Thomas; Wu, Yibing; Gassner, George T; DeGrado, William F

    2016-04-01

    Enzymes use binding energy to stabilize their substrates in high-energy states that are otherwise inaccessible at ambient temperature. Here we show that a de novo designed Zn(II) metalloprotein stabilizes a chemically reactive organic radical that is otherwise unstable in aqueous media. The protein binds tightly to and stabilizes the radical semiquinone form of 3,5-di-tert-butylcatechol. Solution NMR spectroscopy in conjunction with molecular dynamics simulations show that the substrate binds in the active site pocket where it is stabilized by metal-ligand interactions as well as by burial of its hydrophobic groups. Spectrochemical redox titrations show that the protein stabilized the semiquinone by reducing the electrochemical midpoint potential for its formation via the one-electron oxidation of the catechol by approximately 400 mV (9 kcal mol(-1)). Therefore, the inherent chemical properties of the radical were changed drastically by harnessing its binding energy to the metalloprotein. This model sets the basis for designed enzymes with radical cofactors to tackle challenging chemistry. PMID:27001731

  1. Radical Chemistry in the Gas Phase

    Alcaraz, Ch.; Fischer, I.; Schröder, Detlef

    New York: John Wiley and Sons, 2012 - (Chatgilialoglu, C.; Studer, A.), s. 477-502 ISBN 978-0-470-97125-3 Grant ostatní: European Research Council(XE) AdG HORIZOMS Institutional research plan: CEZ:AV0Z40550506 Keywords : radicals * reactive intermediates * gas phase * photoionization * unimolecular reactions * bimolecular reactions Subject RIV: CF - Physical ; Theoretical Chemistry

  2. Radical Islamism and Migrant Integration in Denmark

    Goli, Marco; Rezaei, Shahamak

    2011-01-01

    for – or consequence of - their societal integration. Conventional wisdom suggests: “The more you associate yourself with the cherished and established goals and means, the more you will disassociate yourself from Radical Islamism”, and vice versa. We believe that, quite surprisingly, an empirical test of this idea...

  3. Designed metalloprotein stabilizes a semiquinone radical

    Ulas, Gözde; Lemmin, Thomas; Wu, Yibing; Gassner, George T.; Degrado, William F.

    2016-04-01

    Enzymes use binding energy to stabilize their substrates in high-energy states that are otherwise inaccessible at ambient temperature. Here we show that a de novo designed Zn(II) metalloprotein stabilizes a chemically reactive organic radical that is otherwise unstable in aqueous media. The protein binds tightly to and stabilizes the radical semiquinone form of 3,5-di-tert-butylcatechol. Solution NMR spectroscopy in conjunction with molecular dynamics simulations show that the substrate binds in the active site pocket where it is stabilized by metal-ligand interactions as well as by burial of its hydrophobic groups. Spectrochemical redox titrations show that the protein stabilized the semiquinone by reducing the electrochemical midpoint potential for its formation via the one-electron oxidation of the catechol by approximately 400 mV (9 kcal mol-1). Therefore, the inherent chemical properties of the radical were changed drastically by harnessing its binding energy to the metalloprotein. This model sets the basis for designed enzymes with radical cofactors to tackle challenging chemistry.

  4. Neglected Side Effects After Radical Prostatectomy

    Frey, Anders Ullmann; Sønksen, Jens; Fode, Mikkel

    2014-01-01

    INTRODUCTION: A series of previously neglected sexually related side effects to radical prostatectomy (RP) has been identified over the recent years. These include orgasm-associated incontinence (OAI), urinary incontinence in relation to sexual stimulation (UISS), altered perception of orgasm, or...

  5. Ultraviolet photodissociation dynamics of the phenyl radical

    Ultraviolet (UV) photodissociation dynamics of jet-cooled phenyl radicals (C6H5 and C6D5) are studied in the photolysis wavelength region of 215-268 nm using high-n Rydberg atom time-of-flight and resonance enhanced multiphoton ionization techniques. The phenyl radicals are produced from 193-nm photolysis of chlorobenzene and bromobenzene precursors. The H-atom photofragment yield spectra have a broad peak centered around 235 nm and are in good agreement with the UV absorption spectra of phenyl. The H + C6H4 product translational energy distributions, P(ET)'s, peak near ∼7 kcal/mol, and the fraction of average translational energy in the total excess energy, T>, is in the range of 0.20-0.35 from 215 to 268 nm. The H-atom product angular distribution is isotropic. The dissociation rates are in the range of 107-108 s-1 with internal energy from 30 to 46 kcal/mol above the threshold of the lowest energy channel H +o-C6H4 (ortho-benzyne), comparable with the rates from the Rice-Ramsperger-Kassel-Marcus theory. The results from the fully deuterated phenyl radical are identical. The dissociation mechanism is consistent with production of H +o-C6H4, as the main channel from unimolecular decomposition of the ground electronic state phenyl radical following internal conversion of the electronically excited state.

  6. DNP with Trityl Radicals in Deuterated Polyethylene

    Wang, Li; Meyer, W.; Berlin, A.; Herick, J.; Hess, C.; Reicherz, G.

    2016-02-01

    Chemically doping with trityl radicals was performed in fully deuterated polyethylene. The behavior of paramagnetic centers has been investigated by ESR X-band spectrometer. The highest deuteron polarization was 8% at 2.5 T and 1 K with a spin concentration of 3 × 1019 spins/g.

  7. Modelo epidemiológico para el diagnóstico de intoxicación aguda por plaguicidas

    J.E Altamirano

    2004-01-01

    Full Text Available Se ha investigado en San Salvador de Jujuy el impacto de plaguicidas sobre poblaciones expuestas y para ello se diseñó un modelo epidemiológico que permita diagnosticar Intoxicación Aguda por Plaguicida (IAP, identificar poblaciones en riesgo e investigar parámetros de intoxicaciones. El modelo epidemiológico propuesto se inicia con una capacitación a los agentes sanitarios del hospital en el cual se desarrolla el estudio a fin de introducirlos en la temática, actualizar sus conocimientos al respecto y entrenarlos para realizar la encuesta adjunta al modelo. En esta investigación se evalúan y clasifican los síntomas que los encuestados reconocen haber sufrido, definido previamente los criterios de especificidad (número de síntomas y se agrupa la población investigada según la especificidad de sus síntomas. Aquellos encuestados que registraron simultáneamente cinco o más síntomas especificados se diagnostican como IAP y de esa población la que no acudió durante el evento a un servicio de salud, es considerado subregistro. Este modelo fue probado en una población de trabajadores rurales del tabaco en el departamento El Carmen (Jujuy. Aplicado el modelo se concluye que el 25% de esta población tuvo al menos una IAP y aproximadamente la mitad (49,5% de ellos no acudieron a servicios de salud, lo que constituye el subregistro de IAP. Hay una problemática grave minimizada por la falta de registro y desconocida para acciones de prevención

  8. Complicaciones agudas de la radioterapia externa convencional en el paciente con cáncer de próstata

    Yandry Medina González

    2014-08-01

    Full Text Available Se realizó un estudio descriptivo y retrospectivo con la finalidad de identificar las toxicidades agudas más frecuentes, provocadas por el tratamiento de radioterapia externa convencional en dos dimensiones, en los pacientes diagnosticados con cáncer de próstata en el Instituto Nacional de Oncología y Radiobiología (INOR, en el período comprendido entre 2008 y 2012. Además se evaluaron otras variables de interés para una mejor descripción de la serie. El universo lo constituyeron los adultos con cáncer de próstata inscritos en el INOR (235 y la muestra fue de 138 individuos con cáncer de próstata confirmado y con criterio de recibir tratamiento radiante. Se obtuvo la información a través de la revisión de las historias clínicas que se encontraban en el archivo del Departamento, previa confección de un cuestionario, que se utilizó como instrumento para la recolección de los datos y que permitió evaluar las variables trazadas. Los resultados obtenidos fueron expresados en porcientos y se plasmaron en tablas. Se pudo llegar a la conclusión de que predominaron las edades comprendidas entre 60 y 79 años, los pacientes en etapa clínica III, así como la enfermedad de alto riesgo. Las toxicidades que prevalecieron fueron la disuria, la diarrea y la polaquiuria

  9. Hydroxyl Radical Dosimetry for High Flux Hydroxyl Radical Protein Footprinting Applications Using a Simple Optical Detection Method.

    Xie, Boer; Sharp, Joshua S

    2015-11-01

    Hydroxyl radical protein footprinting (HRPF) by fast photochemical oxidation of proteins (FPOP) is a powerful benchtop tool used to probe protein structure, interactions, and conformational changes in solution. However, the reproducibility of all HRPF techniques is limited by the ability to deliver a defined concentration of hydroxyl radicals to the protein. This ability is impacted by both the amount of radical generated and the presence of radical scavengers in solution. In order to compare HRPF data from sample to sample, a hydroxyl radical dosimeter is needed that can measure the effective concentration of radical that is delivered to the protein, after accounting for both differences in hydroxyl radical generation and nonanalyte radical consumption. Here, we test three radical dosimeters (Alexa Fluor 488, terepthalic acid, and adenine) for their ability to quantitatively measure the effective radical dose under the high radical concentration conditions of FPOP. Adenine has a quantitative relationship between UV spectrophotometric response, effective hydroxyl radical dose delivered, and peptide and protein oxidation levels over the range of radical concentrations typically encountered in FPOP. The simplicity of an adenine-based dosimeter allows for convenient and flexible incorporation into FPOP applications, and the ability to accurately measure the delivered radical dose will enable reproducible and reliable FPOP across a variety of platforms and applications. PMID:26455423

  10. Free Radicals in Superfluid Liquid Helium Nanodroplets: A Pyrolysis Source for the Production of Propargyl Radical

    Küpper, J; Miller, R E; K\\"upper, Jochen; Merritt, Jeremy M.; Miller, Roger E.

    2002-01-01

    An effusive pyrolysis source is described for generating a continuous beam of radicals under conditions appropriate for the helium droplet pick-up method. Rotationally resolved spectra are reported for the $\

  11. THE RADICAL ONLINE: INDIVIDUAL RADICALIZATION PROCESSES AND THE ROLE OF THE INTERNET

    Daniel Koehler

    2014-12-01

    Full Text Available This paper examines in detail the role of the Internet in individual radicalization processes of eight German former right-wing extremists. Applying Grounded Theory methodology the qualitative interviews were analyzed in several coding and re-coding phases. The findings are integrated into the existing literature afterwards. Besides well known factors, such as more effective communication, anonymity and better networking opportunities, this study found evidence that the Internet is a major driving factor to establish and foster the development of radical contrast societies (cf. Koehler, 2015 transmitting radical and violent ideologies and translating them into political activism. As a venue for information exchange, ideological development and training, the individual radicalization process was characteristically shaped or even made possible through the Internet. This paper also shows the high value of qualitative research regarding the topic in contrast to usually employed quantitative analysis of webpage content.

  12. Classical radical hysterectomy and nerve-sparing radical hysterectomy in the treatment of cervical cancer

    Marcin Makowski; Marek Nowak; Marian Szpakowski; Jacek Władziński; Anna Serwach-Nowińska; Łukasz Janas; Jacek R. Wilczyński

    2014-01-01

    Aim of the study: To compare Piver III radical hysterectomy (RH) with nerve-sparing radical hysterectomy (NSRH) for cervical cancer patients in terms of postoperative physiology of pelvic autonomic nerves and perioperative complications. Material and methods : Seventy-three consecutive patients with invasive cervical cancer underwent RH (53 cases) or NSRH (20 cases) from 2001 to 2012 at the Department of Gynecology and Gynecologic Oncology of Polish Mother’s Memorial Hospital – Research...

  13. Spectroscopy of free radicals and radical containing entrance-channel complexes in superfluid helium nanodroplets

    Küpper, J.; Merritt, J.

    2007-01-01

    The spectroscopy of free radicals and radical containing entrance-channel complexes embedded in superfluid helium nano-droplets is reviewed. The collection of dopants inside individual droplets in the beam represents a micro-canonical ensemble, and as such each droplet may be considered an isolated cryo-reactor. The unique properties of the droplets, namely their low temperature (0.4 K) and fast cooling rates ( ~ 1016 K s-1)provides novel opportunities for the formation and high-resolution st...

  14. Environmentally Persistent Free Radicals (EPFRs) - 2. Are Free Hydroxyl Radicals Generated in Aqueous Solutions?

    Khachatryan, Lavrent; Dellinger, Barry

    2011-01-01

    A chemical spin trap, 5,5-dimethyl-1-pyrroline-N-oxide (DMPO), in conjunction with electron paramagnetic resonance (EPR) spectroscopy was employed to measure the production of hydroxyl radical (.OH) in aqueous suspensions of 5% Cu(II)O/silica (3.9% Cu) particles containing environmentally persistent free radicals (EPFRs) of 2-monochlorophenol (2-MCP). The results indicate: 1) a significant differences in accumulated DMPO-OH adducts between EPFR containing particles and non-EPFR control sample...

  15. Role of oxygen free radicals in patients with acute pancreatitis

    Park, Byung Kyu; Chung, Jae Bock; Lee, Jin Heon; Suh, Jeong Hun; Park, Seung Woo; Song, Si Young; Kim, Hyeyoung; Kim, Kyung Hwan; Kang, Jin Kyung

    2003-01-01

    AIM: The generation of oxygen free radicals has been implicated in the pathogenesis of experimental pancreatitis. The aim of this study was to determine the role of oxygen free radicals in patients with acute pancreatitis.

  16. Acute pancreatitis as a postburn complication: report of two cases in children Pancreatitis aguda como complicación de quemadura en dos niños

    Jairo Alberto Patarroyo Serrano

    2007-04-01

    Full Text Available Acute pancreatitis in burnt adults has been reported with some frequency; contrariwise, there has been only one report of this complication in a burnt child. We reviewed the medical records of two childrenwith acute pancreatitis as a postburn complication, who were treated at the Burns Unit of the San Vicente de Paúl Hospital, in Medellín, Colombia. As a result, we add two documented cases to the limited literature on this subject. La pancreatitis aguda ha sido reportada con alguna frecuencia en adultos quemados pero sólo se ha publicado un caso de esta complicación en un niño quemado. Se revisan las historias clínicas de dos niños con pancreatitis aguda como complicación de quemaduras, atendidos en la Unidad de Quemados del Hospital Universitario San Vicente de Paúl (Medellín. Como resultado de la revisión se añaden dos casos bien documentados a la escasa literatura al respecto.

  17. Free radicals, antioxidants and functional foods: Impact on human health

    Lobo, V.; Patil, A.; A Phatak; N Chandra

    2010-01-01

    In recent years, there has been a great deal of attention toward the field of free radical chemistry. Free radicals reactive oxygen species and reactive nitrogen species are generated by our body by various endogenous systems, exposure to different physiochemical conditions or pathological states. A balance between free radicals and antioxidants is necessary for proper physiological function. If free radicals overwhelm the body's ability to regulate them, a condition known as oxidative stress...

  18. The Serbian Radical movement 1881-1903: A historical aspect

    Protić Milan St.

    2005-01-01

    Focusing on the initial stage (until 1903) of the Serbian Radical movement the paper attempts to delineate and explicate the main phases of its political maturation. In its initial stage Serbian Radicalism passed through several significant phases. The earliest phase (1869-80) may be named the period of rudimentary Radicalism. The movement was unorganized and oscillated between the ideas of socialism, anarchism and peasant democracy. The year 1881 saw the founding of the Radical Party as the ...

  19. Synthesis of glycopolymer architectures by reversible-deactivation radical polymerization

    Ali Ghadban; Luca Albertin

    2013-01-01

    This review summarizes the state of the art in the synthesis of well-defined glycopolymers by Reversible-Deactivation Radical Polymerization (RDRP) from its inception in 1998 until August 2012. Glycopolymers architectures have been successfully synthesized with four major RDRP techniques: Nitroxide-mediated radical polymerization (NMP), cyanoxyl-mediated radical polymerization (CMRP), atom transfer radical polymerization (ATRP) and reversible addition-fragmentation chain transfer (RAFT) polym...

  20. Inguinal hernia developed after radical retropubic surgery for prostate cancer

    Chung, Choon Sik; Jeong, Gyu Young; Kim, Seung Han; Lee, Dong Keun

    2013-01-01

    Purpose In this retrospective study, we aimed to compare the clinical characteristics of inguinal hernia developed after radical retropubic surgery for prostate cancer to the hernia without previous radical prostatectomy. Methods Twenty-three patients (group A) who had radical retropubic surgery for prostate cancer underwent laparoscopic or open tension-free inguinal hernia repair from March 2007 to February 2011. Nine hundred and forty patients (group B) without previous radical retropubic s...

  1. Alteraciones cromosómicas en Leucemias mieloides agudas, un estudio de nueve años en 312 pacientes, implicaciones en el diagnóstico, pronóstico, tratamiento y seguimiento de la enfermedad

    Cárdenas Y.

    2001-06-01

    Full Text Available Definir el tipo, frecuencia y distribución de las alteraciones cromosómicas presentes en una población colombiana con diagnóstico de leucemia mieloide aguda. Determinar su asociación con las características clinicopatológicas y analizar su impacto sobre la sobrevida de los pacientes.

  2. Alteraciones cromosómicas en leucemias mieloides agudas, un estudio de nueve años en 312 pacientes, implicaciones en el diagnóstico, pronóstico, tratamiento y seguimiento de la enfermedad

    Cárdenas Y.; García L.; Guevara G.; Medina V.

    2011-01-01

    Definir el tipo, frecuencia y distribución de las alteraciones cromosómicas presentes en una población colombiana con diagnóstico de leucemia mieloide aguda. Determinar su asociación con las características clinicopatológicas y analizar su impacto sobre la sobrevida de los pacientes.

  3. Tratamento da necrose aguda de retina: revisão sistemática Treatment of acute retinal necrosis: systematic review

    Moysés Eduardo Zajdenweber

    2005-08-01

    Full Text Available OBJETIVO: O objetivo deste estudo foi pela realização de revisão sistemática, determinar o melhor tratamento para a necrose aguda de retina. MÉTODOS: Seguindo a orientação metodológica da Colaboração Cochrane e de seu subgrupo editorial "Eye and Vision Group", o autor, por meio de mecanismos de busca, selecionou trabalhos sobre o tratamento da necrose aguda de retina. RESULTADO: Foram selecionadas 146 referências bibliográficas, sendo considerados como relevantes 13 estudos. Destes estudos 2 foram considerados como preenchendo os critérios de inclusão. O primeiro estudo aponta a possibilidade de o tratamento para necrose aguda de retina, com aciclovir endovenoso associado a corticóide sistêmico, proteger o olho contralateral de acometimento. Foram estudados 54 pacientes, 31 tratados e 23 não tratados, sendo observada incidência de doença no olho contralateral de 12,9% no grupo tratado e de 69,5% no grupo não tratado. O segundo estudo incluído mostra 19 olhos acometidos com necrose aguda de retina, sendo que 12 destes olhos foram submetidos à fotocoagulação com laser de argônio, com o objetivo de prevenir o descolamento de retina. Dos 12 olhos, 2 desenvolveram descolamento de retina (16,6% ao passo que, no grupo não tratado, composto por 7 olhos, 4 desenvolveram descolamento de retina (57,1%. CONCLUSÃO: O autor conclui que os dois tipos de intervenção propostos se mostraram eficazes, porém, como os estudos são metodologicamente fracos, torna-se necessária a realização de estudos clínicos randomizados para que se possa estabelecer o melhor tratamento para a necrose aguda de retina.PURPOSE: The purpose of this study was to identify, according to an sistematic review, the best treatment for acute retinal necrosis. METHODS: Following the methodologic guidance of the Cochrane Collaboration and its editorial subgroup "Eye and Vision Group", using search strategy for study identification, articles about the treatment

  4. Hybrid radical energy storage device and method of making

    Gennett, Thomas; Ginley, David S.; Braunecker, Wade; Ban, Chunmei; Owczarczyk, Zbyslaw

    2016-04-26

    Hybrid radical energy storage devices, such as batteries or electrochemical devices, and methods of use and making are disclosed. Also described herein are electrodes and electrolytes useful in energy storage devices, for example, radical polymer cathode materials and electrolytes for use in organic radical batteries.

  5. Radical radiotherapy for carcinoma of the vulva

    Slevin, N.J.; Pointon, R.C.S.

    1989-02-01

    A study was made of 58 patients with carcinoma of the vulva treated by radical radiotherapy between 1965 and 1982. The choice of treatment technique was influenced by site and extent of disease as well as the general condition of the patient. The crude 5-year survival was 26% (15/58). Local control was achieved in 40% of cases and was associated with tumour size of 4 cm or less. Radionecrosis occurred in nine cases but none of these required surgical intervention. Surgery remains the treatment of choice for carcinoma of the vulva. This report emphasizes that radical radiotherapy has a curative potential in those cases considered unsuitable for surgery and that the necrosis type and rate are within the limits of acceptable morbidity.

  6. Radical radiotherapy for carcinoma of the vulva

    A study was made of 58 patients with carcinoma of the vulva treated by radical radiotherapy between 1965 and 1982. The choice of treatment technique was influenced by site and extent of disease as well as the general condition of the patient. The crude 5-year survival was 26% (15/58). Local control was achieved in 40% of cases and was associated with tumour size of 4 cm or less. Radionecrosis occurred in nine cases but none of these required surgical intervention. Surgery remains the treatment of choice for carcinoma of the vulva. This report emphasizes that radical radiotherapy has a curative potential in those cases considered unsuitable for surgery and that the necrosis type and rate are within the limits of acceptable morbidity. (author)

  7. Editorial: RADICALISM AND POLITICS OF RELIGION

    Editorial Al-Jami'ah: Journal of Islamic Studies

    2008-02-01

    Full Text Available Radical Islamism has become the “sexiest” issue in the international scholarship of religion since the September 11 tragedy in 2001. It has been associated with a number of terrorist attacks not only in the West but also in Muslim countries. Every single of radical Islamism has caught the interest of not only scholars and policy makers but also general public. Interestingly, the general assumption that religion is the source of peace has been seriously challenged, not by non-religious communities, but by the violent practices of particular religious groups, however small they are. Indeed, there are certain groups striving for Islam but by using acts which could give awful image on Islam itself and against humanity.

  8. EPR study of free radicals in bread

    Yordanov, Nicola D.; Mladenova, Ralitsa

    2004-05-01

    The features of the recorded EPR spectra of paramagnetic species formed in bread and rusk are reported. The appearance of free radicals in them is only connected with their thermal treatment since the starting materials (flour and grains) exhibit very weak EPR signal. The obtained EPR spectra are complex and indicate that: (i) the relative number of paramagnetic species depends on the temperature and treating time of the raw product; (ii) the g-values are strongly temperature dependent with a tendency to coincide at t≥220 °C. Because of the relatively low (150-220 °C) temperature of thermal treatment, the studied free radicals can be assumed to appear in the course of the browning (Maillard) reaction and not to the carbonization of the material.

  9. Anion photoelectron spectroscopy of radicals and clusters

    Travis, Taylor R.

    1999-12-16

    Anion photoelectron spectroscopy is used to study free radicals and clusters. The low-lying {sup 2}{Sigma} and {sup 2}{Pi} states of C{sub 2n}H (n = 1--4) have been studied. The anion photoelectron spectra yielded electron affinities, term values, and vibrational frequencies for these combustion and astrophysically relevant species. Photoelectron angular distributions allowed the author to correctly assign the electronic symmetry of the ground and first excited states and to assess the degree of vibronic coupling in C{sub 2}H and C{sub 4}H. Other radicals studied include NCN and I{sub 3}. The author was able to observe the low-lying singlet and triplet states of NCN for the first time. Measurement of the electron affinity of I{sub 3} revealed that it has a bound ground state and attachment of an argon atom to this moiety enabled him to resolve the symmetric stretching progression.

  10. Radical Scavenging Effects of Different Veronica species

    Ummuhan Şebnem Harput; Yasin Genç; Newaj Khan; İclal Saracoglu

    2011-01-01

    It is well known that the excessive production of reactive oxygen species is hazardous for living organisms and damages major cellular constituents such as DNA, lipid and protein. To find new products reducing free radical damage is very important researches in recent pharmaceutical investigations. Considering this information, fourteen Veronica species are decided to research in the view point of their antioxidant capacity and the chemical content. Water extracts of the plants were tested fo...

  11. Ultraviolet photodissociation dynamics of the cyclohexyl radical

    Lucas, Michael; Liu, Yanlin; Zhang, Jingsong

    2015-03-01

    Cycloalkanes are important components in conventional fuels and oil shale derived fuels and the combustion of cyclohexane fuels leads to the production of benzene, a pollutant precursor. One of the pathways from cyclohexane to benzene is through sequential hydrogen loss, including the cyclohexyl radical as an intermediate. The ultraviolet (UV) photodissociation dynamics of the cyclohexyl (c-C6H11) radical was studied for the first time using the high- n Rydberg atom time-of-flight (HRTOF) technique in the range of 232-262 nm. The translational energy distributions of the H-atom loss product channel, P (ET) 's, show a large translational energy release and a large fraction of average translational energy in the total excess energy, , from 232-262 nm. The H-atom product angular distribution is anisotropic with a positive β parameter. The most likely H-atom loss pathway is an axial H ejection from the β-carbon in cyclohexyl to form cyclohexene + H, which along with the positive β parameter, indicates that the transition dipole moment, μ, is perpendicular to the ring. The P (ET) and anisotropy of the H-atom loss product channel are significantly larger than those expected for a statistical unimolecular dissociation of a hot radical, indicating a non-statistical dissociation mechanism. The dissociation mechanism is consistent with direct dissociation on a repulsive excited state surface or on the repulsive part of the ground state surface to produce cyclohexene + H, possibly mediated by a conical intersection. Cyclohexyl is the largest radical so far showing a direct dissociation mechanism.

  12. Computed tomography after radical pancreaticoduodenectomy (Whipple's procedure)

    Whipple's procedure (radical pancreaticoduodenectomy) is currently the only curative option for patients with periampullary malignancy. The surgery is highly complex and involves multiple anastomoses. Complications are common and can lead to significant postoperative morbidity. Early detection and treatment of complications is vital, and high-quality multidetector computed tomography (MDCT) is currently the best method of investigation. This review outlines the surgical technique and illustrates the range of normal postoperative appearances together with the common complications

  13. EI igualitarismo radical de John Rawls

    Rodríguez Zepeda, Jesús

    2004-01-01

    The main purpose of this paper is to offer an interpretation of the canonical statement of justice as fairness (A Theory of Justice) as a deeply egalitarian, even radical, argument. In order to do so, the categories of justice as fairness strongly related to the egalitarian and distributive meaning of the rawlsian liberal model and, specifically, those aimed to solve the problem of social justice, are accurately revised, namely, the fair equality of opportunity and the diff...

  14. The radical of a vertex operator algebra

    Dong, C.; Li, H.; Mason, G.; Montague, P

    1996-01-01

    The radical $J(V)$ of a vertex operator algebra $V$ is defined to be the subspace of $V$ consisting of vectors $v$ such that the zero mode $o(v)=0$ on $V$ where $o(v)=v_{wt v-1}$ if $v$ is homogeneous. We establish various facts about $o(v),$ including the determination of $J(V)$ which is shown to be essentially equal to $(L(0)+L(-1))V.$

  15. AQUEOUS STABLE FREE RADICAL POLYMERIZATION PROCESSES

    Andrea R. Szkurhan; Michael K. Georges

    2004-01-01

    An overview of aqueous polymerizations, which include emulsion, miniemulsion and suspension polymerizations,under stable free radical polymerization (SFRP) conditions is presented. The success of miniemulsion and suspension SFRP polymerizations is contrasted with the difficulties associated with obtaining a stable emulsion polymerization. A recently developed unique microprecipitation technique is referenced as a means of making submicron sized particles that can be used to achieve a stable emulsion SFRP process.

  16. EARLY POSTOPERATIVE COMPLICATIONS AFTER RADICAL CYSTECTOMY

    V. O. Mager

    2014-08-01

    Full Text Available Radical cystectomy (RCE is associated with a considerable number of early postoperative complications as before. Based on 10 years’ experience, this paper demonstrates the frequency (33.9 % and types of early complications following RCE, as well as postoperative mortality (5.5 % and its resulting causes. Although postoperative mortality is relatively low today, the frequency of early postoperative complications remains high as before.

  17. International Radical Cystectomy Consortium: A way forward

    Raza, Syed Johar; Field, Erinn; Kibel, Adam S.; Mottrie, Alex; Weizer, Alon Z; Wagner, Andrew; Hemal, Ashok K.; Scherr, Douglas S.; Schanne, Francis; Gaboardi, Franco; Wu, Guan; Peabody, James O.; Koauk, Jihad; Redorta, Joan Palou; Pattaras, John G.

    2014-01-01

    Robot-assisted radical cystectomy (RARC) is an emerging operative alternative to open surgery for the management of invasive bladder cancer. Studies from single institutions provide limited data due to the small number of patients. In order to better understand the related outcomes, a world-wide consortium was established in 2006 of patients undergoing RARC, called the International Robotic Cystectomy Consortium (IRCC). Thus far, the IRCC has reported its findings on various areas of operativ...

  18. Learning Curve of Robotic Radical Prostatectomy

    Muhammed Ersagun Arslan; Abdullah Erdem Canda; Ali Fuat Atmaca; Mevlana Derya Balbay; Ziya Akbulut; Serkan Altinova; Ahmet Tunc Ozdemir

    2015-01-01

    Introduction: Prostate cancer (PrC) is the fifth most common malignancy worldwide and the second most common malignancy in men. Currently, robotic-assisted laparoscopic radical prostatectomy (RARP) has become a popular treatment for localised PrC treatment worldwide. We aimed to assess the learning curve of RARP in our institution. Methods: A total of 391 patients who underwent RARP in our clinic between February 2009 and April 2013 were included in the study. We retrospectively evaluated ...

  19. Chemical Nonlinearities and Radical Pair Lifetime Estimation

    Robinson, Gregory

    2013-03-01

    Much attention has recently developed around chemical reactions that depend on applied static magnetic fields as weak as earth's. This interest is largely motivated by experiments that implicate the role of spin-selective radical pair recombination in biological magnetic sensing. Existing literature uses a straightforward calculation to approximate the expected lifetime of coherent radical pairs as a function of the minimum RF amplitude that is observed to disrupt magnetic navigation, apparently by decohering the radical pair via electronic Zeeman excitations. But we show that chemical nonlinearities can preclude direct computation of coherent pair lifetime without considering the cellular signalling mechanisms involved, and discuss whether it can explain the surprising fragility of some animals' compass sense. In particular, we demonstrate that an autocatalytic cycle can introduce threshold effects on the disruption sensitivity to applied oscillatory magnetic fields. We will show examples in the mean-field limit and consider the consequences of noise and fluctuations in the Freidlin-Wentzell picture of perturbed dynamical systems.

  20. Complications of Radical Cystectomy and Orthotopic Reconstruction

    Wei Shen Tan

    2015-01-01

    Full Text Available Radical cystectomy and orthotopic reconstruction significant morbidity and mortality despite advances in minimal invasive and robotic technology. In this review, we will discuss early and late complications, as well as describe efforts to minimize morbidity and mortality, with a focus on ileal orthotopic bladder substitute (OBS. We summarise efforts to minimize morbidity and mortality including enhanced recovery as well as early and late complications seen after radical cystectomy and OBS. Centralisation of complex cancer services in the UK has led to a fall in mortality and high volume institutions have a significantly lower rate of 30-day mortality compared to low volume institutions. Enhanced recovery pathways have resulted in shorter length of hospital stay and potentially a reduction in morbidity. Early complications of radical cystectomy occur as a direct result of the surgery itself while late complications, which can occur even after 10 years after surgery, are due to urinary diversion. OBS represents the ideal urinary diversion for patients without contraindications. However, all patients with OBS should have regular long term follow-up for oncological surveillance and to identify complications should they arise.

  1. Radical correction of Budd-Chiari syndrome

    LI Xiao-qiang; WANG Zhong-gao; MENG Qing-you; SANG Hong-fei; QIAN Ai-min; DUAN Peng-fei; RONG Jian-jie

    2007-01-01

    Background Interventional therapy is widely accepted as the first choice for the treatment of the Budd-Chiari syndrome,but the use of radical correctional therapy should not be discarded. This study describes radical correction by controlling bleeding from distal end of pathological segment of the inferior vena cava (IVC) and discusses potential surgical errors and postoperative complications.Methods Of the 216 patients in the study, 78 were treated with simple membranectomy, 64 with dissection of the pathological segment of the IVC and vascular prosthesis or pericardial patch plasty, 60 with resection of the pathological segment of the IVC and orthotopic graft transplantation with vascular prosthesis, and 14 with resection of the occlusive main hepatic vein and its upper IVC, hepatic venous outflow plasty and vascular prosthesis orthotopic graft transplantation from the hepatic venous entrance to the IVC of right atrial ostium.Results Except 14 cases who were discharged after hepatic vein outflow plasty, four cases died postoperatively, and 198 patients were discharged without complications. The symptoms of 15 patients were relieved partially and 2 without any change. There were no deaths intraoperatively. Of the 112 cases who were followed up for 72 months, 13 suffered from a relapse.Conclusions Radical correction is a beneficial therapy in the treatment of Budd-Chiari syndrome.

  2. Radical inactivation of a biological sulphydryl molecule

    Reactive species produced from the free radical-induced chain oxidation of low molecular weight sulphydryl-containing molecules in aerated solutions deactivate the sulphydryl-containing enzyme papain, forming both reparable mixed disulphides and non-reparable products. This inactivation is highly efficient for penicillamine and glutathione, but almost negligible with cysteine, which is a protector of papain for [cysteine] / [papain] >= 5 under all conditions used. In the case of glutathione, superoxide dismutase caused only a small reduction in the inactivation and peroxide yields were small, implying that the deactivating species are not .O2- but RSOO. radicals or products from them. For penicillamine, however, dimutase was highly effective and the peroxide yields were relatively large, demonstrating that .O2- or a radical with similar capabilities for forming H2O2 and being deactivated by dismutase was involved. Although in the presence of dismutase penicillamine is a better protector of non-reparable papain inactivation than glutathione, it suffers from a deficiency in that the papain-penicillamine mixed disulphide, which is always formed, cannot be repaired by spontaneous reaction with RSH molecules. (author)

  3. The detection of hydroxyl radicals in vivo.

    Freinbichler, Wolfhardt; Bianchi, Loria; Colivicchi, M Alessandra; Ballini, Chiara; Tipton, Keith F; Linert, Wolfgang; Corte, Laura Della

    2008-01-01

    Several indirect methods have been developed for the detection and quantification of highly reactive oxygen species (hROS), which may exist either as free hydroxyl radicals, bound "crypto" radicals or Fe(IV)-oxo species, in vivo. This review discusses the strengths and weaknesses associated with those most commonly used, which determine the hydroxylation of salicylate or phenylalanine. Chemical as well as biological arguments indicate that neither the hydroxylation of salicylate nor that of phenylalanine can guarantee an accurate hydroxyl radical quantitation in vivo. This is because not all hydroxylated product-species can be used for detection and the ratio of these species strongly depends on the chemical environment and on the reaction time. Furthermore, at least in the case of salicylate, the high concentrations of the chemical trap required (mM) are known to influence biological processes associated with oxidative stress. Two, newer, alternative methods described, the 4-hydroxy benzoic acid (4-HBA) and the terephthalate (TA) assays, do not have these drawbacks. In each case reaction with hROS leads to only one hydroxylated product. Thus, from a chemical viewpoint, they should provide a better hROS quantitation. Further work is needed to assess any possible biological effects of the required millimolar (4-HBA) and micromolar (TA) concentrations of the chemical traps. PMID:18262275

  4. Incidencia de insuficiencia renal aguda en niños hospitalizados por quemaduras en el Hospital Universitario San Vicente de Paúl de Medellín, 2007-2008

    José William Cornejo Ochoa

    2008-11-01

    Full Text Available INTRODUCCIÓN: las quemaduras en niños se han identificado como causa principal de trauma y su asociación con insuficiencia renal aguda es una de las complicaciones más temidas debido a su alta tasa de mortalidad. OBJETIVO: establecer la incidencia de insuficiencia renal aguda y describir algunos de los factores asociados en niños quemados menores de 18 años atendidos en el Hospital Universitario San Vicente de Paúl de Medellín. MATERIALES Y MÉTODOS: estudio de cohorte prospectivo y descriptivo en pacientes menores de 18 años con quemaduras superiores al 30% de la superficie corporal total que ingresaron al Servicio de quemados del Hospital Universitario San Vicente de Paúl entre abril del 2007 y febrero 2008. RESULTADOS: en total se incluyeron 25 pacientes en el estudio y de acuerdo con los criterios utilizados el 64% desarrollaron insuficiencia renal aguda y presentaron una tasa de mortalidad del 12,5% mientras que en el grupo sin insuficiencia renal aguda no se presentaron muertes. No se encontraron diferencias significativas entre los dos grupos en ninguna de las variables, lo que podría deberse al tamaño de la muestra; sin embargo, la lesión por inhalación se vislumbra como un factor importante de riesgo. CONCLUSIONES: la insuficiencia renal aguda en pacientes quemados es una complicación muy frecuente y se la debe buscar activamente y hacerles un seguimiento estrecho a los pacientes. Hacen falta más estudios en Medellín para determinar los factores de riesgo asociados a esta complicación.

  5. Formation of long-lived radicals on proteins by radical transfer from heme enzymes--a common process?

    Ostdal, H; Andersen, H J; Davies, Michael Jonathan

    1999-01-01

    albumin via the heme edge of the peroxidase. In contrast, albumin radical formation by the HRP/H2O2/free tyrosine system was only marginally affected by proteolysis, consistent with free tyrosine phenoxyl radicals being the mediators of radical transfer, without significant protein-protein interaction...

  6. Generation of acetyl free radicals by radiolysis: comparison of free radicals generated from acetaldehyde and ethylene-glycol

    The optical absorption spectra of the intermediates obtained by pulse radiolysis of N2O-saturated solutions of acetaldehyde or ethylene-glycol and the kinetics of their decays have been investigated. Results suggest that the OH· radical reactions with acetaldehyde or ethylene-glycol produce acetyl and formylmethyl radicals. Besides, these radicals are shown to reduce ferricytochrome c

  7. Disfagia aguda de causa oncológica: Manejo terapéutico Acute dysphagia of oncological origin: Therapeutic treatment

    F. Arias

    2004-01-01

    Full Text Available La disfagia es uno de los síntomas más frecuentes en los pacientes con tumores de cabeza y cuello, y esófago. Éste puede ser el síntoma inicial o, más frecuentemente, relacionado con el tratamiento oncológico. Se revisan los aspectos fisiopatológicos y terapéuticos más importantes de la disfagia aguda de causa oncológica. La deglución es un proceso complejo en el que intervienen numerosas estructuras músculo-esqueléticas bajo el control neurológico de diversos pares craneales. La compleja coordinación neuromuscular necesaria para una correcta deglución puede verse afectada por numerosas situaciones tanto por efecto de los tumores como de su tratamiento, fundamentalmente la cirugía o la radioterapia. En conclusión, se puede afirmar que para un adecuado tratamiento de la disfagia oncológica, es preciso una correcta evaluación inicial y un tratamiento activo, ya que del control de la disfagia, depende no sólo la calidad de vida del paciente, sino en numerosas ocasiones la posibilidad de continuar el tratamiento y por tanto de mantener las posibilidades de curación.Dysphagia is one of the most frequent syndromes in patients with tumours of the head and neck, and the oesophagus. This can be the initial symptom or, more frequently, related to the oncological treatment. We review the most important therapeutic and physio-pathological aspects of acute dysphagia of oncological origin. Deglutition is a complex process in which numerous muscular-skeletal structures intervene under the neurological control of different cranial nerves. The complex neuro-muscular coordination needed for a correct deglutition can be affected by numerous situations, both from the effect of the tumours and from their treatment, basically surgery or radiotherapy. In conclusion, it can be affirmed that for a suitable treatment of oncological dysphagia, a correct initial evaluation and an active treatment are required, since not only the patient’s quality

  8. Consenso intersociedades para el manejo de infecciones respiratorias: bronquitis aguda y enfermedad pulmonar obstructiva crónica

    Gustavo Lopardo

    2013-04-01

    Full Text Available La Sociedad Argentina de Infectología convocó a otras sociedades científicas para elaborar una guía práctica y actualizada para el manejo del tratamiento antibiótico de las bronquitis agudas (BA y los episodios de reagudización de enfermedad pulmonar obstructiva crónica (EPOC, con el objetivo de promover el uso racional de los recursos diagnósticos y terapéuticos. La BA se caracteriza por la inflamación del árbol bronquial que afecta tanto a adultos como a niños sin enfermedades pulmonares crónicas, siendo de origen viral en la mayoría de los casos. El diagnóstico es clínico, debiéndose diferenciar de los episodios de neumonía adquirida en la comunidad. El tratamiento de los episodios de BA es fundamentalmente sintomático. En huéspedes inmunocomprometidos, con enfermedades crónicas respiratorias o cardíacas y en adultos mayores con comorbilidades debe evaluarse el requerimiento de tratamiento antibiótico caso por caso. Se define como exacerbación de la EPOC al cambio agudo en la situación clínica basal del paciente más allá de la variabilidad diaria, que cursa con aumento de la disnea, aumento de la expectoración, expectoración purulenta, o cualquier combinación de estos tres síntomas, y que precisa un cambio terapéutico. La presencia de uno de estos síntomas se define como episodio leve, dos como moderado y tres como grave. En un 50 a 75% de las exacerbaciones de EPOC se aísla en el esputo un agente infeccioso. En los episodios moderados y graves debe iniciarse tratamiento antibiótico. Amoxicilina-inhibidor de betalactamasas, macrólidos y fluoroquinolonas se encuentran entre las opciones terapéuticas.

  9. ENFOQUE DEL PACIENTE CON INTOXICACIÓN AGUDA POR PLAGUICIDAS ORGANOS FOSFORADOS Organophosphorates: acute intoxication practical issues

    Carlos Mauricio Hurtado Clavijo

    2005-10-01

    Full Text Available Un gran número de insecticidas organofosforados se usan en todo el mundo a diario. Las intoxicaciones ocurren generalmente de forma accidental por exposición laboral, o intencional, con fines suicidas. Los organofosforados producen sus efectos tóxicos a través de la inhibición de la acetilcolinesterasa, la enzima responsable de la hidrólisis del neurotransmisor acetilcolina, produciendo ácido acético y colina, productos químicamente inertes. La unión entre los organofosforados y la acetilcolina es una unión irreversible espontáneamente, sin embargo, puede ser reversible con el uso de antídotos específico llamados oximas. La administración temprana de pralidoxima es crucial y muy útil si se inicia en las primeras seis horas luego de la intoxicación aguda. La atropina produce un beneficio clínico dramático para los síntomas muscarínicos del síndrome colinérgico. Pueden ocurrir complicaciones importantes en los pacientes por intoxicación con organofosforados, como hipotensión, arritmias cardíacas fatales, síndrome intermedio, distres respiratorio, neumonía y aún disfunción cerebral severa.Every day more organic phosphorus insecticides, are used in the entire world. Intoxications happen generally accidentally for exhibition work, or intentional as suicides. Organic phosphorus compounds, produces toxic effects, through the inhibition of the acetylcholinesterase, the enzyme responsible for the hydrolisys of the acetylcholine, neurotransmisor producing acetic acid and colina, chemically inert products. The binding between the organic phosphorus compounds and the acetylcholine is spontaneously and irreversible, however, it can be reversible with the use of an antidote specific called oximas. The early administration of pralidoxima is crucial, great benefits are obtained if it begins in the first six hours after the acute intoxication. Atropine produces a dramatic clinical benefit for the symptoms muscarinic of the syndrome

  10. O escore de risco de sangramento como preditor de mortalidade em pacientes com síndromes coronarianas agudas

    José Carlos Nicolau

    2013-12-01

    Full Text Available FUNDAMENTO: A ocorrência de sangramento aumenta a mortalidade intra-hospitalar em pacientes com síndromes coronarianas agudas (SCAs, e há uma boa correlação entre os escores de risco de sangramento e a incidência de eventos hemorrágicos. No entanto, o papel dos escores de risco de sangramento como fatores preditivos de mortalidade é pouco estudado. OBJETIVO: Analisar o papel do escore de risco de sangramento como fator preditivo de mortalidade intra-hospitalar numa coorte de pacientes com SCA tratados num centro terciário de cardiologia. MÉTODOS: Dos 1.655 pacientes com SCA (547 com SCA com supra de ST e 1.118 com SCA sem supra de ST, calculou-se o escore de risco de sangramento ACUITY/HORIZONS prospectivamente em 249 pacientes e retrospectivamente nos demais 1.416. Informações sobre mortalidade e complicações hemorrágicas também foram obtidas. RESULTADOS: A idade média da população estudada foi 64,3 ± 12,6 anos e o escore de risco de sangramento médio foi 18 ± 7,7. A correlação entre sangramento e mortalidade foi altamente significativa (p < 0,001; OR = 5,29, assim como a correlação entre escore de sangramento e hemorragia intra-hospitalar (p < 0,001; OR = 1,058, e entre escore de sangramento e mortalidade intra-hospitalar (OR ajustado = 1,121, p < 0,001, área sob a curva ROC 0,753; p < 0,001. O OR ajustado e a área sob a curva ROC para a população com SCA com supra de ST foram 1,046 (p = 0,046 e 0,686 ± 0,040 (p < 0,001, respectivamente, e para SCA sem supra de ST foram 1,150 (p < 0,001 e 0,769 ± 0,036 (p < 0,001, respectivamente. CONCLUSÃO: O escore de risco de sangramento é um fator preditivo muito útil e altamente confiável para mortalidade intra-hospitalar em uma grande variedade de pacientes com SCAs, especialmente aqueles com angina instável ou infarto agudo do miocárdio sem supra de ST.

  11. Escore Prognóstico para Síndrome Coronariana Aguda em Hospital Terciário Privado

    Edson Renato Romano

    2014-04-01

    Full Text Available Fundamento: Os modelos prognósticos disponíveis para Síndrome Coronariana Aguda (SCA podem ter limitações de performance, por terem sido elaborados há vários anos, ou problemas de aplicabilidade. Objetivos: Elaborar escores para predição de eventos desfavoráveis em 30 dias e 6 meses, em pacientes com SCA, com ou sem Supradesnivelamento de ST (SST, atendida em hospital privado terciário. Métodos: Coorte prospectiva de pacientes consecutivos com SCA admitidos entre agosto/2009 a junho/2012. O desfecho primário composto foi a ocorrência de óbito, infarto ou reinfarto, Acidente Vascular Cerebral (AVC, parada cardiorrespiratória e sangramento maior. As variáveis preditoras foram selecionadas de dados clínicos, laboratoriais, eletrocardiográficos e da terapêutica. O modelo final foi obtido por meio de regressão logística e submetido a validação interna, utilizando-se bootstraping. Resultados: Incluímos 760 pacientes, 132 com SCA com SST e 628 sem SST. A idade média foi 63,2 ± 11,7 anos, sendo 583 homens (76,7%. O modelo final para eventos em 30 dias contém cinco preditores: idade ≥ 70 anos, antecedente de neoplasia, Fração de Ejeção do Ventrículo Esquerdo (FEVE 12,4 ng/mL e trombólise. Na validação interna, o modelo mostrou ter boa performance com área sob a curva de 0,71.Os preditores do modelo para 6 meses são: antecedente de neoplasia, FEVE 14,3 ng/mL, creatinina > 1,2 mg/dL, antecedente de doença pulmonar obstrutiva crônica e hemoglobina < 13,5 g/dL. Na validação interna, o modelo apresentou boa performance com área sob a curva de 0,69. Conclusões: Desenvolvemos escores de fácil utilização e boa performance para predição de eventos adversos em 30 dias e 6 meses em pacientes com SCA.

  12. Adiponectina sérica e risco cardiometabólico em pacientes com síndromes coronarianas agudas

    Gustavo Bernardes de Figueiredo Oliveira

    2013-11-01

    Full Text Available FUNDAMENTO: O tecido adiposo representa não somente uma fonte de energia estocável, mas principalmente um órgão endócrino que secreta várias citoquinas. A adiponectina, uma nova proteína semelhante ao colágeno, foi descoberta como uma citoquina específica do adipócito e um promissor marcador de risco cardiovascular. OBJETIVO: Avaliar a associação entre os níveis séricos da adiponectina e o risco para a ocorrência de eventos cardiovasculares, em pacientes com síndromes coronarianas agudas (SCA, e as correlações entre adiponectina e os biomarcadores metabólicos, inflamatórios e miocárdicos. MÉTODOS: Foram recrutados 114 pacientes com SCA, com seguimento médio de 1,13 ano para avaliação de desfechos clínicos. Modelos de regressão de risco proporcional de Cox com penalização de Firth foram construídos para determinar a associação independente entre adiponectina e o risco subsequente dos desfechos primário (composto de óbito cardiovascular/IAM não fatal/AVE não fatal e coprimário (composto de óbito cardiovascular/ IAM não fatal/AVE não fatal/re-hospitalização requerendo revascularização. RESULTADOS: Houve correlações diretas e significantes entre adiponectina e idade, HDL-colesterol e BNP, e inversas e significantes entre adiponectina e circunferência abdominal, peso corporal, índice de massa corporal, índice HOMA, triglicerídeos e insulina. A adiponectina foi associada a maior risco para os desfechos primário e coprimário (HR ajustado 1,08 e 1,07/incremento de 1.000, respectivamente, p = 0,01 e p = 0,02. CONCLUSÃO: Em pacientes com SCA, a adiponectina sérica foi preditor de risco independente para eventos cardiovasculares. De modo adicional às correlações antropométricas e metabólicas, a adiponectina mostrou correlação significante com BNP.

  13. Custo-efetividade de fondaparinux em pacientes com Síndrome Coronariana Aguda sem supradesnivelamento do ST

    Camila Pepe

    2012-07-01

    Full Text Available FUNDAMENTO: O uso combinado de agentes antitrombínicos, antiplaquetários e estratégias invasivas na síndrome coronariana aguda sem supradesnivelamento do ST (SCAsSST reduz eventos cardiovasculares. O fondaparinux demonstrou equivalência à enoxaparina na redução de eventos cardiovasculares, porém com menor índice de sangramento nos pacientes que usaram fondaparinux. OBJETIVO: Avaliar o custo-efetividade de fondaparinux versus enoxaparina em pacientes com SCAsSST no Brasil a partir da perspectiva econômica do Sistema Único de Saúde (SUS. MÉTODOS: Um modelo de decisão analítico foi construído para calcular os custos e consequências resultantes dos tratamentos comparados. Os parâmetros do modelo foram obtidos do estudo OASIS-5 (N = 20.078 pacientes com SCAsSST randomizados para fondaparinux ou enoxaparina. O desfecho avaliado foi um composto de eventos cardiovasculares (isto é, morte, infarto agudo do miocárdio, isquemia refratária e sangramentos graves nos dias 9, 30 e 180 pós-SCAsSST. Foram avaliados todos os custos diretos de tratamento e eventos relacionados à SCAsSST. O ano da análise foi 2010 e os custos foram descritos em reais (R$. RESULTADOS: No dia 9, o custo de tratamento por paciente foi R$ 2.768 para fondaparinux e R$ 2.852 para enoxaparina. Aproximadamente 80% do custo total foram associados a tratamentos invasivos. Os custos com medicamentos representaram 10% do custo total. As taxas combinadas de eventos cardiovasculares e de sangramentos maiores foram 7,3% e 9,0% para fondaparinux e enoxaparina, respectivamente. Análises de sensibilidade confirmaram os resultados iniciais do modelo. CONCLUSÃO: O fondaparinux para tratamento de pacientes com SCAsSST é superior à enoxaparina em termos de prevenção de novos eventos cardiovasculares com menor custo. (Arq Bras Cardiol. 2012; [online].ahead print, PP.0-0

  14. Intoxicaciones agudas en Santiago de Compostela,en un período de cuatro años

    P. Fernández

    2003-01-01

    Full Text Available El objetivo de este trabajo fue evaluar las caracterís-ticas de un grupo de pacientes intoxicados en el área sanitaria deSantiago de Compostela. Para ello, se estudiaron 1192 intoxica-ciones agudas atendidas en el Servicio de Urgencias y Unidadde Cuidados Intensivos del Hospital Clínico Universitario deesta ciudad, desde el 1 de enero de 1993 al 31 de diciembre de1996. Se han considerado solo aquellos casos en los que se soli-citó un análisis toxicológico a este Instituto de Medicina Legal,desconociéndose el número de casos excluidos. Se diseñó unaficha clínica con todos los parámetros estudiados para su cum-plimentación por los médicos en el momento del ingreso. Seobservó un predominio del sexo masculino (61,4% y una edadmedia, en la población estudiada, de 32,3±12,5 años (rango: 15-93 años. Los tóxicos más frecuentemente implicados fueron lasdrogas de abuso (681 casos, seguidas de los fármacos (545casos y de “otros agentes” (88 casos. Las intoxicaciones vo-luntarias estaban asociadas mayoritariamente con mujeres y coningesta de fármacos, en contra de las accidentales, asociadas conhombres y con consumo de drogas de abuso. Existen anteceden-tes psiquiátricos en 332 casos, tratamiento farmacológico previoen 219 casos, alcoholismo en 189 casos y drogadicción por víaparenteral en 144 casos. Se ha constatado que un 76% de lospacientes presentaban alguna clínica al ingreso, con un predo-minio de las manifestaciones neurológicas (682 casos. Se utili-zó algún tipo de tratamiento específico en 574 sujetos, desta-cando la aplicación de lavado gástrico (444 casos y la adminis-tración de antídotos (358 casos. La mayoría de los pacientesevolucionó satisfactoriamente, con solo un 2% de mortalidad.Esta información permite conocer los patrones de abuso y la efi-cacia del tratamiento aplicado con el fin de mejorar el controldel paciente intoxicado

  15. Determinación de Proteína C Reactiva como predictor de severidad en Pancreatitis Aguda.

    Pablo Betancour M.

    2009-12-01

    Full Text Available INTRODUCCION: La proteína C reactiva (PCR es un examen simple y de bajo costo que según la literatura tiene buena asociación para la evaluación pronóstica en Pancreatitis Aguda (PA. OBJETIVO: Determinar valor pronóstico de PCR para severidad, presencia de complicaciones y mortalidad intrahospitalaria de PA. MATERIAL Y METODO: Estudio de cohorte retrospectiva de pacientes adultos ingresados al Hospital Dr. Gustavo Fricke, Viña del Mar durante el año 2007. Se identificaron características generales, etiología, score de Balthazar, PCR, complicaciones y mortalidad. Se utilizó test de Mann Whitney para comparación de medianas y curvas ROC. RESULTADOS: Se incluyeron 59 pacientes, siendo el 54,23% hombres. La mediana de edad fue 51 años. La etiología biliar se observó en 57,62%. La mediana de hospitalización fueron 12 días. El 40,67% presentó complicaciones, siendo más frecuente la necrosis pancreática (20,33%. El nivel de PCR mostró diferencias significativas entre pacientes con y sin gravedad imagenológica (33,5mg/dL vs 15,9mg/dL, p=0,0009, complicaciones intrahospitalarias (40mg/dL vs 15,9mg/dL, p<0,0001 y mortalidad intrahospitalaria (66mg/dL vs 22mg/dL, p=0,0061. El área bajo la curva ROC fue de 0,75; 0,84 y 0,91 respectivamente, todos estadísticamente significativos. La sensibilidad, especificidad, likelihood ratio (LR positivo, LR negativo para gravedad imagenológica con un punto de corte de 13,14mg/dL fue 88%, 54%, 1,83 y 0,28 respectivamente. Para predecir mortalidad con un valor de 32,76mg/dL, estos fueron 100%, 71%, 3,43 y 0 respectivamente. DISCUSION. Un valor de PCR de 40mg/dL es buen marcador pronóstico de complicaciones intrahospitalarias. Niveles aumentados tienen alta sensibilidad para predecir gravedad imagenológica y mortalidad intrahospitalaria.

  16. Uso de iodóforo tópico em feridas agudas Uso del yodo tópico y/o compuestos en heridas agudas Use of topic iodine in acute wounds

    Alcicléa dos Santos Oliveira

    2008-03-01

    Full Text Available Esta pesquisa objetivou realizar revisão sistemática da literatura relacionada ao uso de iodóforos tópicos no tratamento de feridas agudas. Os ensaios clínicos foram localizados por meio da Base de Dados Cochrane, utilizando-se os seguintes descritores: iodine, acute wound, treatment, healing, infection, surgery, surgical. Vinte (52,6%, dentre 38 artigos, enquadraramse nos critérios de inclusão, sendo analisados quanto às características dos periódicos e dos estudos e classificados em: iodóforo versus outros agentes tópicos (4/ 20%; iodóforo versus coberturas (1/ 5%; iodóforo versus soro fisiológico (5/ 25%; iodóforo versus sem iodóforo (8/ 40% e iodóforos em diferentes concentrações (2/ 10%. Resultados favoráveis para os iodóforos ocorreram em 45% dos artigos. Quanto às tendências dos resultados, três dentre cinco artigos mostraram-se favoráveis para a cicatrização de feridas e prevenção de infecção e nove dentre 15 artigos foram desfavoráveis ao uso de iodóforos tópicos quando somente a prevenção de infecção foi investigada.En esta investigación se tuvo como objetivo realizar una revisión sistemática de la literatura respecto a la utilización del yodo tópico y/o compuestos en el tratamiento de las heridas agudas. Los ensayos clínicos fueron localizados por medio de la Base de Datos Cochrane, utilizándose los siguientes descriptores: iodine, acute wound, treatment, healing, infection, surgery, surgical. Veinte (52,6%, de 38 artículos, se encuadraron en los criterios de inclusión, siendo analizados en cuanto a las características de los periódicos y de los estudios y clasificados en: yodo versus otros agentes tópicos (4/ 20%; yodo versus apósitos (1/ 5%; yodo versus solución fisiológica (5/ 25%; yodo versus sin yodo (8/ 40% y yodo en diferentes concentraciones (2/ 10%. Resultados favorables para el yodo se obtuvieron en el 45% de los artículos. En cuanto a las tendencias de los resultados

  17. Spatial features of radical reactions in irradiated solids

    The Electron Spin Echo (ESE) method is used to obtain data on the spatial distribution of radical particles originated in irradiated solid matrices from two types of precursors: ionized molecules (R+-type radicals), and secondary electrons (R--type radicals). For methanol with Cd+2 acceptors and for water solutions of acids and alkalis the radical tracks are shown to have a complex structure. Possible reasons for long path lengths of secondary electrons in polar media are analyzed. Pair distribution functions, as well as their changes due to diffusion and chemical reactions, are reported for radicals generated by photolysis and radiolysis. (author)

  18. Progress in measurement of free radicals in biological systems

    Free radicals generation and oxidative stress are involved in many pathological processes including neuro-degenerated diseases, diabetes, tumorigenesis and radiation damage. Measurement of free radicals is of importance in the field of radiation protection and radiation damage. The electron spinning resonance (ESR) techniques for measurement of free radicals in biological systems are summarized according to the literature and the author's research work in this review. The recent emerging immuno-spin trapping method for analysis of protein radicals and DNA radicals is also introduced. (authors)

  19. Peroxy radical chemistry and OH radical production during the NO3-initiated oxidation of isoprene

    P. O. Wennberg

    2012-01-01

    Full Text Available Peroxy radical reactions (RO2 + RO2 from the NO3-initiated oxidation of isoprene are studied with both gas chromatography and a chemical ionization mass spectrometry technique that allows for more specific speciation of products than in previous studies of this system. We find high nitrate yields (>~80%, consistent with other studies. We further see evidence of significant hydroxyl radical (OH formation in this system, which we propose comes from RO2 + HO2 reactions with a yield of ~42–62%. An additional OH source is the second generation oxidation of the nitrooxyhydroperoxide, which produces OH and a dinitrooxyepoxide with a yield of ~35%. The branching ratio of the radical propagating, carbonyl- and alcohol-forming, and dimer-forming channels of the RO2 + RO2 reaction are found to be ~18–38%, ~59–77%, and ~3–4%, respectively. HO2 formation in this system is lower than has been previously assumed. Addition of RO2 to isoprene is suggested as a possible route to the formation of several isoprene dimer compounds (ROOR. The nitrooxy, allylic, and C5 peroxy radicals present in this system exhibit different behavior than the limited suite of peroxy radicals that have been studied to date.

  20. Inactivation efficiencies of radical reactions with biologically active DNA

    Lafleur, M. V. M.; Retèl, J.; Loman, H.

    Dilute aqueous solutions of biologically active θX174 DNA may serve as a simplified model system of the cell. Damage to the DNA after irradiation with γ-rays, may be ascribed to reactions with .OH, .H and e -aq or secondary radicals, arising from reactions of water radicals with added scavengers. Conversion of primary (water) radicals into secondary (scavenger) radicals leads to a considerable protection of the DNA, which, however, would have been larger if these secondary radicals did not contribute to DNA inactivation. The inactivation yield due to isopropanol or formate (secondary) radicals depends on dose rate as well as DNA concentration. Furthermore the inactivation efficiencies of the reactions of both the primary and the secondary radicals with single-stranded DNA could be established.

  1. Radical intermediates involved in the bleaching of the carotenoid crocin. Hydroxyl radicals, superoxide anions and hydrated electrons

    Bors, W.; Saran, M.; Michel, C. (Gesellschaft fuer Strahlen- und Umweltforschung m.b.H. Muenchen, Neuherberg (Germany, F.R.). Abt. Strahlenbiologie)

    1982-05-01

    The participation of the primary radicals in the bleaching of aqueous solutions of the carotenoid crocin by ionizing radiation was investigated, employing both X-radiolysis and pulse radiolysis. The pulse-radiolytic data demonstrated a very rapid diffusion-controlled attack by both hydroxyl radicals (radicalsOH) and hydrated electrons (e/sup -/sub(aq)), while superoxide anions (O/sub 2//sup -/) did not react at all. The site of the initial reaction of these radicals was not limited to the polyene chromophore. Slower secondary reactions involving crocin alkyl or peroxy radicals contribute mainly to the overall bleaching, in particular during steady-state irradiation.

  2. Radical intermediates involved in the bleaching of the carotenoid crocin. Hydroxyl radicals, superoxide anions and hydrated electrons

    The participation of the primary radicals in the bleaching of aqueous solutions of the carotenoid crocin by ionizing radiation was investigated, employing both X-radiolysis and pulse radiolysis. The pulse-radiolytic data demonstrated a very rapid diffusion-controlled attack by both hydroxyl radicals (radicalsOH) and hydrated electrons (e-sub(aq)), while superoxide anions (O2-) did not react at all. The site of the initial reaction of these radicals was not limited to the polyene chromophore. Slower secondary reactions involving crocin alkyl or peroxy radicals contribute mainly to the overall bleaching, in particular during steady-state irradiation. (author)

  3. Pancreatite aguda leve: avaliação pela ultra-sonografia. estudo prospectivo Mild acute pancreatitis: ultrasound evaluation: a prospective study

    Márcio Martins Machado

    2002-07-01

    Full Text Available Resumo Neste estudo foram avaliados, por meio da ultra-sonografia, 21 pacientes com pancreatite aguda leve. Foram analisadas a presença ou ausência de hipoecogenicidade do pâncreas e a presença ou ausência de líquido peripancreático. Em 19 pacientes (90,5% foi identificada hipoecogenicidade pancreática, e em três (15,8% destes pacientes foi identificada a presença de pequena quantidade de líquido na pequena cavidade dos epíploons. Em dois pacientes (9,5% não se identificou qualquer alteração pancreática. Com relação à possível etiologia da pancreatite aguda, em 15 pacientes (71,5% pôde-se demonstrar a presença de colecistopatia calculosa, em quatro pacientes (19,0% havia história de alcoolismo crônico e não foram identificados cálculos na vesícula biliar, e em dois pacientes (9,5% não foi identificada qualquer causa aparente. Os autores concluem que a ultra-sonografia pode identificar alteração na maioria dos pacientes com pancreatite aguda leve e permite, ainda, o acompanhamento daqueles com pequenas coleções líquidas peripancreáticas.We analyzed the ultrasonographic findings of 21 patients with mild acute pancreatitis. The presence or absence of pancreatic hypoechogenicity and peripancreatic fluid collection was assessed. Pancreatic hypoechogenicity was identified in 19 patients (90.5% whereas small sac fluid collection was identified in 3 (15.8% of these patients. No abnormality was seen in 2 patients (9.5%. Regarding the etiology of acute pancreatitis, cholelithiasis was identified in 15 patients (71.5%, alcohol abuse was identified in 4 patients (19.0%, and in 2 patients (9.5% no probable etiology could be found. The authors conclude that ultrasonography may identify abnormalities in the majority of patients with mild acute pancreatitis and can be used to assess patients with peripancreatic fluid collections.

  4. Manejo da asma aguda em adultos na sala de emergência: evidências atuais Management of acute asthma in adults in the emergency room: current evidence

    Paulo de Tarso Roth Dalcin

    2009-01-01

    Full Text Available Asma é uma doença com uma alta prevalência em nosso meio e ao redor do mundo. Embora novas opções terapêuticas tenham sido recentemente desenvolvidas, parece haver um aumento mundial na sua morbidade e mortalidade. Em muitas instituições, as exacerbações asmáticas ainda se constituem em uma emergência médica muito comum. As evidências têm demonstrado que o manejo da asma aguda na sala de emergência concentra decisões cruciais que podem determinar o desfecho desta situação clínica. Nesta revisão, enfocaremos a avaliação e o tratamento do paciente com asma aguda na sala de emergência, descrevendo uma estratégia apropriada para o seu manejo. Serão consideradas as seguintes etapas: diagnóstico, avaliação da gravidade, tratamento, avaliação das complicações, decisão sobre onde se realizará o tratamento adicional e orientações por ocasião da alta da emergência. Espera-se que estas recomendações contribuam para que o médico clínico tome as decisões apropriadas durante o manejo da asma aguda na sala de emergência.Asthma is a disease with high prevalence in our country and worldwide. Although new therapeutic approaches have been developed recently, there seems to be a global increase in morbidity and mortality from asthma. In many institutions, asthma exacerbation is still a common medical emergency. Clinical evidence demonstrates that management of acute asthma in the emergency room entails crucial decisions that could determine the clinical outcome. In this review, the authors focus on assessment and treatment of patients with acute asthma and outline an appropriate management strategy. Diagnosis, severity assessment, treatment, complications, decision about where additional treatment will take place and orientations on discharge from the emergency will be considered. It is expected that these recommendations will help physicians to make the appropriate decisions about care of acute asthma in the emergency

  5. Pancreatitis aguda secundaria a hipertrigliceridemia: presentación de dos casos clínicos Acute pancreatitis secondary to hypertriglyceridemia: A report of two cases

    S. J. Jiménez Forero

    2008-06-01

    Full Text Available La pancreatitis aguda es un proceso inflamatorio reversible. La hipertrigliceridemia como etiología de la pancreatitis aguda varía entre un 1,3 y un 11%, de acuerdo a la literatura, cuando los niveles de triglicéridos alcanzan valores por encima de 1.000 mg/dl; sin embargo, la hipertrigliceridemia se observa en un 12 a un 39% de las pancreatitis agudas como factor asociado. El objetivo del tratamiento médico es aumentar la actividad de la lipoproteinlipasa y aumentar la degradación de los quilomicrones; disminuyendo así los valores plasmáticos de triglicéridos a niveles menores de 500 mg/dl, incluso a menos de 200 mg/dl si es posible con diferentes estrategias, entre ellas la insulina. En el presente artículo, presentamos dos casos clínicos de pancreatitis severas inducidas por hipertrigliceridemia, manejadas con terapia de infusión de insulina con adecuada respuesta clínica y paraclínica con disminución significativa de los niveles de triglicéridos, 48 horas postratamiento.Acute pancreatitis is a reversible inflammatory process. Hypertriglyceridemia as a cause of acute pancreatitis reaches frequencies of 1.3-11% according to the literature when triglyceride levels reach values over 1,000 mg/dl; nevertheless hypertriglyceridemia is observed in 12-39% of acute pancreatitis cases as an associated factor. The objective of medical treatment is to increase lipoprotein-lipase activity, and to increase chylomicron breakdown thus diminishing serum triglycerides to levels smaller than 500 or even 200 mg/dl (when possible using a variety of strategies including insulin administration. In the present article, we report two cases of severe pancreatitis induced by hypertriglyceridemia that were managed with insulin infusion; both responded adequately, as measured by a significant reduction of triglyceride levels at 48 hours post-treatment.

  6. Picosecond Control of Photogenerated Radical Pair Lifetimes Using a Stable Third Radical.

    Horwitz, Noah E; Phelan, Brian T; Nelson, Jordan N; Krzyaniak, Matthew D; Wasielewski, Michael R

    2016-05-12

    Photoinduced electron transfer reactions in organic donor-acceptor systems leading to long-lived radical ion pairs (RPs) have attracted broad interest for their potential applications in fields as diverse as solar energy conversion and spintronics. We present the photophysics and spin dynamics of an electron donor - electron acceptor - stable radical system consisting of a meta-phenylenediamine (mPD) donor covalently linked to a 4-aminonaphthalene-1,8-dicarboximide (ANI) electron-accepting chromophore as well as an α,γ-bisdiphenylene-β-phenylallyl (BDPA) stable radical. Selective photoexcitation of ANI produces the BDPA-mPD(+•)-ANI(-•) triradical in which the mPD(+•)-ANI(-•) RP spins are strongly exchange coupled. The presence of BDPA is found to greatly increase the RP intersystem crossing rate from the initially photogenerated BDPA-(1)(mPD(+•)-ANI(-•)) to BDPA-(3)(mPD(+•)-ANI(-•)), resulting in accelerated RP recombination via the triplet channel to produce BDPA-mPD-(3*)ANI as compared to a reference molecule lacking the BDPA radical. The RP recombination rates observed are much faster than those previously reported for weakly coupled triradical systems. Time-resolved EPR spectroscopy shows that this process is also associated with strong spin polarization of the stable radical. Overall, these results show that RP intersystem crossing rates can be strongly influenced by stable radicals nearby strongly coupled RP systems, making it possible to use a third spin to control RP lifetimes down to a picosecond time scale. PMID:27108738

  7. Radical hysterectomy with adjuvant radiotherapy versus radical radiotherapy for FIGO stage IIB cervical cancer

    The goal of this study was to compare treatment outcomes for Federation of Gynecology and Obstetrics (FIGO) stage IIB cervical carcinoma patients receiving radical surgery followed by adjuvant postoperative radiotherapy versus radical radiotherapy. Medical records of FIGO stage IIB cervical cancer patients treated between July 2008 and December 2011 were retrospectively reviewed. A total of 148 patients underwent radical hysterectomy with pelvic lymph node dissection followed by adjuvant radiotherapy (surgery-based group). These patients were compared with 290 patients that received radical radiotherapy alone (RT-based group). Recurrence rates, progression-free survival (PFS), overall survival (OS), local control rates, and treatment-related complications were compared for these two groups. Similar rates of recurrence (16.89% vs. 12.41%, p = 0.200), PFS (log-rank, p = 0.211), OS (log-rank, p = 0.347), and local control rates (log-rank, p = 0.668) were observed for the surgery-based group and the RT-based group, respectively. Moreover, the incidence of acute grade 3–4 gastrointestinal reactions and late grade 3–4 lower limb lymphedema were significantly higher for the surgery-based group versus the RT-based group. Cox multivariate analyses found no significant difference in survival outcome between the two groups, and tumor diameter and histopathology were identified as significant prognostic factors for OS. Radical radiotherapy was associated with fewer treatment-related complications and achieved comparable survival outcomes for patients with FIGO stage IIB cervical cancer compared to radical hysterectomy followed by postoperative radiotherapy

  8. Spectroscopy of free-base N-confused tetraphenylporphyrin radical anion and radical cation.

    Alemán, Elvin A; Manríquez Rocha, Juan; Wongwitwichote, Wongwit; Godínez Mora-Tovar, Luis Arturo; Modarelli, David A

    2011-06-23

    The radical anions and radical cations of the two tautomers (1e and 1i) of 5,10,15,20-tetraphenyl N-confused free-base porphyrin have been studied using a combination of cyclic voltammetry, steady state absorption spectroscopy, and computational chemistry. N-Confused porphyrins (NCPs), alternatively called 2-aza-21-carba-5,10,15,20-tetraphenylporphyrins or inverted porphyrins, are of great interest for their potential as building blocks in assemblies designed for artificial photosynthesis, and understanding the absorption spectra of the corresponding radical ions is paramount to future studies in multicomponent arrays where electron-transfer reactions are involved. NCP 1e was shown to oxidize at a potential of E(ox) 0.65 V vs Fc(+)|Fc in DMF and reduce at E(red) -1.42 V, while the corresponding values for 1i in toluene were E(ox) 0.60 V and E(red) -1.64 V. The geometries of these radical ions were computed at the B3LYP/6-31+G(d)//B3LYP/6-31G(d) level in the gas phase and in solution using the polarizable continuum model (PCM). From these structures and that of H(2)TPP and its corresponding radical ions, the computed redox potentials for 1e and 1i were calculated using the Born-Haber cycle. While the computed reduction potentials and electron affinities were in excellent agreement with the experimental reduction potentials, the calculated oxidation potentials displayed a somewhat less ideal relationship with experiment. The absorption spectra of the four radical ions were also measured experimentally, with radical cations 1e(•+) and 1i(•+) displaying significant changes in the Soret and Q-band regions as well as new low energy absorption bands in the near-IR region. The changes in the absorption spectra of radical anions 1e(•-) and 1i(•-) were not as dramatic, with the changes occurring only in the Soret and Q-band regions. These results were favorably modeled using time-dependent density functional calculations at the TD-B3LYP/6-31+G(d)//B3LYP/6-31G

  9. Uma análise behaviorista radical dos sonhos A radical behaviorist analysis of the dreams

    Francynete Melo e Silva

    2000-01-01

    Embora não haja um consenso acerca de questões sobre o que são os sonhos, porque sonhamos, etc., a maioria dos estudos sobre a natureza dos sonhos concorda que ela está relacionada a condições internas do organismo. Contrariamente, o behaviorismo radical analisa os sonhos como comportamentos privados, sendo produtos das histórias filogenética, ontogenética e cultural. Neste sentido, este trabalho tem como objetivo analisar os sonhos a partir da perspectiva behaviorista radical, considerando-o...

  10. Studies of radiation-produced radicals and radical ions. Progress report, September 1, 1982-August 31, 1983

    During the past year, radiation chemical and solid-state ESR techniques were combined to generate and characterize novel radical ions. Observations have been made on a variety of metastable organometallic radical cations derived from Group IV B metal alkyls. Matrix interactions have been discovered between radical cations and the Freon solvent. The radical cation formed from ethylene oxide is the ring-opened 2-oxa-trimethylene cation with a symmetrical C/sub 2v/ planar structure. The CF3CCl2 radical was formed after γ irradiation of the CF3CCl3 (Freon) matrix. Very large long-range proton hyperfine couplings were found in radical cations of carbonyl compounds. The C8F8- ion was studied in MTHF glass, using ESR. Two new inorganic radicals, SF4- and SF4O-, were discovered

  11. RISE OF RADICALIZATION IN THE GLOBAL VILLAGE. ONLINE RADICALIZATION VS. IN-PERSON RADICALIZATION - IS THERE A DIFFERENCE?

    Tanja Dramac Jiries

    2016-03-01

    Full Text Available In the vicinity of open space, some authors have called the “dark web” the perfect “breeding grounds” for generating conditions for seeds of extremism to thrive and grow. The perceived anonymity and vast information databases found here present a perfect incubator for terrorist activity. Academics and policymakers alike are as well convinced that such an open space filled with recruiter masterminds is perfectly adept at embracing the unadoptable, unconventional, or socially unfit into terrorist or jihadi organizations. Nevertheless, regardless of organizations, modernization and adoption of new technological methods in which one can obtain ideas and information, many individuals are still and to a great extent, influenced by face-to-face interactions. Intimate environments of a religious institution, somewhat of a home-like feeling in community gathering center, can equally impact a person, as can the internet and its vast informational influence. For the reason of contributing to understand the radicalization in the Global Village, this article will examine differences in online and in-person radicalization and illustrate it with some examples and attempt to make a comparison between two different exposures to information and its effects on young individuals.

  12. Isoprene, sulphoxy radical-anions and acidity

    K. J. Rudziński

    2008-12-01

    Full Text Available Transformation of isoprene coupled with autoxidation of SIV in aqueous solutions was studied experimentally and by chemical-kinetic modelling over broad range of solution acidities (pH=3–9 to complement the research on aqueous-phase and heterogeneous transformation of isoprene reported recently by many laboratories. Isoprene significantly slowed down the autoxidation in acidic and basic solutions, and accelerated it slightly in neutral solutions. Simultaneously, production of sulphate ions and formation of solution acidity were significantly reduced. Formation of sulphite and sulphate derivatives of isoprene – sulphurous acid mono-(2-methyl-4-oxo-but-2-enyl ester (m/z=162.9, sulphurous acid mono-(4-hydroxy-2-methyl-but-2-enyl ester (m/z=164.9, sulphuric acid mono-(2-methyl-4-oxo-but-2-enyl ester (m/z=178.9, sulphuric acid mono-(4-hydroxy-2-methyl-but-2-enyl ester (m/z=180.9 – was indicated by mass spectroscopic analysis of post-reaction mixtures. The results of experiments were explained by changes in a subtle quantitative balance of three superimposed processes whose rates depended in different manner on the acidity of reacting solutions – the scavenging of sulphoxy radicals by isoprene, the formation of sulphoxy radicals during further reactions of isoprene radicals, and the autoxidation of SIV itself. A chemical mechanism based on this idea was explored numerically to show good agreement with experimental data. Interaction of isoprene with sulphur(IV species and oxygen can possibly result in formation of new organosulphate components of atmospheric aerosols and waters, and influence distribution of reactive sulphur and oxygen species in isoprene-emitting organisms exposed to SIV pollutants.

  13. Hydroxyl radical induced oxidation of nitrobenzene

    The hydroxylation of nitrobenzene by radiolytic techniques was examined by high-performance liquid chromatographic techniques. Owing to improvements in the method of analysis it was possible to measure phenol in air-saturated nitrobenzene solutions irradiated to low doses. The initial yields for the consumption of nitrobenzene and the formation of phenol and isomeric nitrophenols in N2O- and air-saturated systems were measured in order to establish the primary reactions of hydroxyl radicals with nitrobenzene. The initial yields for the consumption of nitrobenzene were 3.7 and 2.6 and that for total phenol were 2.3 and 2.4 in N2O- and air-saturated systems, respectively, in samples irradiated at low dose rates (0.8 krad g-1 min-1). Nearly 80 percent of the hydroxynitrocyclohexadienyl radicals disproportionate to produce isomeric nitrophenols and nitrobenzene in N2O-saturated systems without added oxidants upon irradiation at low dose rates. For a given dose the distribution of nitrophenols was dependent upon the dose rate. Observed dose rate dependence of nitrophenol production and dose rate independence of nitrobenzene consumption indicate that reactions other than disporportional and dimerization play a significant role at high dose reates. The examination of the effect of added ferricyanide ion in N2O-saturated systems showed that reliable production measurements of o- and p-nitrophenol cannot be made because of complicating secondary reactions. The initial yield for the production of m-nitrophenol was higher by a factor of greater than 3 in the presence than in the absence of ferricyanide ion. This result indicates that in the cross disproportionation reaction of m- and o- or p-hydroxynitrocyclohexadienyl radicals the meta isomer acts as an oxidizing agent and ortho and para isomers act as reducing agents. (U.S.)

  14. Rehabilitation of erectile function following radical prostatectomy

    Andrew R. McCullough

    2008-01-01

    The concept of muscle rehabilitation after nerve injury is not a novel idea and is practiced in many branches of medicine, including urology. Bladder rehabilitation after spinal cord injury is universally practiced. The erectile dysfunction (ED) experienced after radical prostatectomy (RP) is increasingly recognized as being primarily neurogenic followed by secondary penile smooth muscle (SM) changes. There is unfortunately no standard approach to penile rehabilitation after RP because controlled prospective human studies are not available. This article reviews the epidemiology, experimental pathophysiological models, rationale for penile rehabilitation, and currently published rehabilitation strategies.

  15. Superzoom. Italia y el compromiso radical

    Parga Prado, Marcos

    2015-01-01

    Italy: the new domestic landscape, la ambiciosa exposición que en 1972 tuvo lugar en el MoMA, supone la consagración y a la vez escenifica la muerte de lo que algunos críticos acababan de catalogar como Arquitectura Radical, término con el que intentaban unificar el trabajo de un heterogéneo y atomizado grupo de arquitectos, principalmente italianos, comprometidos con el replanteamiento total de la definición y objetivos de la disciplina. Se ponía fin así a un corto pero intenso periodo d...

  16. Resonance Raman study of benzyl radical

    Langkilde, F.W.; Bajdor, K.; Wilbrandt, R.

    1992-01-01

    Time-resolved resonance Raman spectra are obtained of benzyl radicals created by laser flash photolysis of benzylchloride and diphenylacetone in solution. The spectra are obtained in resonance with the intense 2 2A2-1 B-2(2) transition of benzyl. The strong Raman bands are assigned to totally...... symmetric a1 modes. The remaining observed bands are tentatively assigned to fundamental modes of b1, a2, and b2 symmetry, and to overtones and combinations. The resonance Raman spectra are found to be quite different from previous fluorescence spectra of benzyl, and the origins of these differences are...

  17. Acetyl radical generation in cigarette smoke: Quantification and simulations

    Hu, Na; Green, Sarah A.

    2014-10-01

    Free radicals are present in cigarette smoke and can have a negative effect on human health. However, little is known about their formation mechanisms. Acetyl radicals were quantified in tobacco smoke and mechanisms for their generation were investigated by computer simulations. Acetyl radicals were trapped from the gas phase using 3-amino-2, 2, 5, 5-tetramethyl-proxyl (3AP) on solid support to form stable 3AP adducts for later analysis by high-performance liquid chromatography (HPLC), mass spectrometry/tandem mass spectrometry (MS-MS/MS) and liquid chromatography-mass spectrometry (LC-MS). Simulations were performed using the Master Chemical Mechanism (MCM). A range of 10-150 nmol/cigarette of acetyl radical was measured from gas phase tobacco smoke of both commercial and research cigarettes under several different smoking conditions. More radicals were detected from the puff smoking method compared to continuous flow sampling. Approximately twice as many acetyl radicals were trapped when a glass fiber particle filter (GF/F specifications) was placed before the trapping zone. Simulations showed that NO/NO2 reacts with isoprene, initiating chain reactions to produce hydroxyl radical, which abstracts hydrogen from acetaldehyde to generate acetyl radical. These mechanisms can account for the full amount of acetyl radical detected experimentally from cigarette smoke. Similar mechanisms may generate radicals in second hand smoke.

  18. Lipid radicals: Properties and detection by spin trapping

    Unsaturated lipids are rapidly oxidized to toxic products such as lipid hydroperoxides, especially when transition metals such as iron or copper are present. In a Fenton-type reaction Fe2+ converts lipid hydroperoxides to the very short-lived lipid alkoxyl radicals. The reaction was started upon the addition of Fe2+ to an aqueous linoleic acid hydroperoxide (LOOH) emulsion and the spin trap in the absence of oxygen. Even when high concentrations of spin traps were added to the incubation mixture, only secondary radical adducts were detected, probably due to the rapid rearrangement of the primary alkoxyl radicals. With the commercially available nitroso spin trap MNP we observed a slightly immobilized ESR spectrum with only one hydrogen splitting, indicating the trapping of a methinyl fragment of a lipid radical. With DMPO or 5-diethoxyphosphoryl-5-methyl-1-pyrroline N-oxide (DEPMPO) adducts were detected with carbon-centered lipid radical, with acyl radical, and with the hydroxyl radical. We also synthesized lipophilic derivatives of the spin trap DEPMPO in order to detect lipid radical species generated in the lipid phase. With all spin traps studied a lipid-derived carbon-centered radical was obtained in the anaerobic incubation system Fe2+/LOOH indicating the trapping of a lipid radical, possibly generated as a secondary reaction product of the primary lipid alkoxyl radical formed. Under aerobic conditions an SOD-insensitive oxygen-centered radical adduct was formed with DEPMPO and its lipophilic derivatives. The observed ESR parameters were similar to those of alkoxyl radical adducts, which were independently synthesized in model experiments using Fe3+-catalyzed nucleophilic addition of methanol or t-butanol to the respective spin trap. (author)

  19. Impacto económico de la desnutrición crónica, aguda y global en el Perú

    Lorena Alcázar; Diego Ocampo; Lucio Huamán-Espino; Juan Pablo Aparco

    2013-01-01

    Objetivos. Estimar el impacto económico de la desnutrición crónica, aguda y global en el Perú. Materiales y métodos. El presente estudio estimó el impacto económico de la desnutrición infantil en dos horizontes temporales (incidental retrospectiva y prospectiva) para el año 2011, considerando los costos asociados a la desnutrición en salud, educación y productividad para la economía peruana. Se combinó la información proveniente de la Encuesta Demográfica de Salud Familiar, la Encuesta Nacion...

  20. Avaliação da reprodutibilidade da tomografia computadorizada no estadiamento da pancreatite aguda Reproducibility in the assessment of acute pancreatitis with computed tomography

    Edison de Oliveira Freire Filho

    2007-12-01

    Full Text Available OBJETIVO: Medir a reprodutibilidade da tomografia computadorizada sem e com contraste na avaliação da gravidade da pancreatite aguda. MATERIAIS E MÉTODOS: Cinqüenta e um exames de tomografia computadorizada abdominal sem e com contraste de pacientes com pancreatite aguda foram analisados por dois radiologistas (observadores 1 e 2. Calculamos o índice morfológico pela tomografia computadorizada sem e com contraste, separadamente, e o índice de gravidade da tomografia computadorizada para pancreatite aguda. Medimos a reprodutibilidade intra- e interobservador da tomografia computadorizada através do índice kappa (kapa. RESULTADOS: Para a concordância interobservador obtivemos kapa de 0,666, 0,705, 0,648, 0,547 e 0,631 para índice morfológico sem e com contraste, presença de necrose pancreática, extensão da necrose pancreática e índice de gravidade da tomografia computadorizada, respectivamente. Para a concordância intra-observador dos observadores 1 e 2 obtivemos, respectivamente, kapa de 0,796 e 0,732 para o índice morfológico sem contraste; 0,725 e 0,802 para o índice morfológico com contraste; 0,674 e 0,849 para a presença de necrose pancreática; 0,606 e 0,770 para a extensão da necrose pancreática; e 0,801 e 0,687 para o índice de gravidade da tomografia computadorizada. CONCLUSÃO: O estadiamento da pancreatite aguda pela tomografia computadorizada por meio do índice morfológico e do índice de gravidade da tomografia computadorizada é um método bastante reprodutível. O não-uso do contraste não afeta a reprodutibilidade da tomografia computadorizada para o cálculo do índice morfológico.OBJECTIVE: To evaluate the reproducibility of unenhanced and contrast-enhanced computed tomography in the assessment of patients with acute pancreatitis. MATERIALS AND METHODS: Fifty-one unenhanced and contrast-enhanced abdominal computed tomography studies of patients with acute pancreatitis were blindly reviewed by two