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Sample records for adhesion model burgers

  1. Discrete Element Simulation of Asphalt Mastics Based on Burgers Model

    LIU Yu; FENG Shi-rong; HU Xia-guang

    2007-01-01

    In order to investigate the viscoelastic performance of asphalt mastics, a micro-mechanical model for asphalt mastics was built by applying Burgers model to discrete element simulation and constructing Burgers contact model. Then the numerical simulation of creep tests was conducted, and results from the simulation were compared with the analytical solution for Burgers model. The comparision snowed that the two results agreed well with each other, suggesting that discrete element model based on Burgers model could be employed in the numerical simulation for asphalt mastics.

  2. Burgers Turbulence

    Bec, Jeremie; Khanin, Konstantin

    2007-01-01

    The last decades witnessed a renewal of interest in the Burgers equation. Much activities focused on extensions of the original one-dimensional pressureless model introduced in the thirties by the Dutch scientist J.M. Burgers, and more precisely on the problem of Burgers turbulence, that is the study of the solutions to the one- or multi-dimensional Burgers equation with random initial conditions or random forcing. Such work was frequently motivated by new emerging applications of Burgers mod...

  3. Burgers turbulence

    The last decades witnessed a renewal of interest in the Burgers equation. Much activities focused on extensions of the original one-dimensional pressureless model introduced in the thirties by the Dutch scientist J.M. Burgers, and more precisely on the problem of Burgers turbulence, that is the study of the solutions to the one- or multi-dimensional Burgers equation with random initial conditions or random forcing. Such work was frequently motivated by new emerging applications of Burgers model to statistical physics, cosmology, and fluid dynamics. Also Burgers turbulence appeared as one of the simplest instances of a nonlinear system out of equilibrium. The study of random Lagrangian systems, of stochastic partial differential equations and their invariant measures, the theory of dynamical systems, the applications of field theory to the understanding of dissipative anomalies and of multiscaling in hydrodynamic turbulence have benefited significantly from progress in Burgers turbulence. The aim of this review is to give a unified view of selected work stemming from these rather diverse disciplines

  4. The decay of multiscale signals deterministic model of the Burgers turbulence

    Gurbatov, S N

    2000-01-01

    This work is devoted to the study of the decay of multiscale deterministicsolutions of the unforced Burgers' equation in the limit of vanishingviscosity. A deterministic model of turbulence-like evolution is considered. We con-struct the initial perturbation as a piecewise linear analog of the Weierstrassfunction. The wavenumbers of this function form a "Weierstrass spectrum", whichaccumulates at the origin in geometric progression."Reverse" sawtooth functionswith negative initial slope are used in this series as basic functions, whiletheir amplitudes are chosen by the condition that the distribution of energyover exponential intervals of wavenumbers is the same as for the continuousspectrum in Burgers turbulence. Combining these two ideas allows us to obtainan exact analytical solution for the velocity field. We also notice that suchmultiscale waves may be constructed for multidimensional Burgers' equation. This solution has scaling exponent h=-(1+n)/2 and its evolution in time isself-similar with logarithmi...

  5. Mathematical modeling and exact solutions to rotating flows of a Burgers' fluid

    The aim of this study is to provide the modeling and exact analytic solutions for hydromagnetic oscillatory rotating flows of an incompressible Burgers' fluid bounded by a plate. The governing time-dependent equation for the Burgers' fluid is different than those from the Navier-Stokes' equation. The entire system is assumed to rotate around an axis normal to the plate. The governing equations for this investigation are solved analytically for two physical problems. The solutions for the three cases, when the two times angular velocity is greater than the frequency of oscillation or it is smaller than the frequency or it is equal to the frequency (resonant case), are discussed in second problem. In Burgers' fluid, it is also found that hydromagnetic solution in the resonant case satisfies the boundary condition at infinity. Moreover, the obtained analytical results reduce to several previously published results as the special cases. (author)

  6. Burger Jihad

    Rytter, Mikkel

    2016-01-01

    Based on a number of ‘burger episodes’ during ten days of itikaf at a Sufi lodge in Pakistan, this article discusses the difficulties of religious self-cultivation among young Muslim pilgrims from Denmark. The focus on food and eating is not only used to discuss how religious brotherhoods and...

  7. Fractional modelling for BBM-Burger equation by using new homotopy analysis transform method

    Sunil Kumar

    2014-10-01

    Full Text Available The purpose of this study is to introduce a new analytical method namely, fractional homotopy analysis transform method (FHATM for series solution of the time fractional BBM-Burger equation. The homotopy analysis transform method is an innovative adjustment in Laplace transform algorithm (LTA for nonlinear fractional partial differential equation in fluid dynamics and makes the calculation much simpler. The proposed scheme finds the solutions of nonlinear problems without any discretization, restrictive assumptions and avoids the rounding off errors. The numerical solutions obtained by the proposed method indicate that the approach is easy to implement and computationally very attractive.

  8. Analytical solutions for wall slip effects on magnetohydrodynamic oscillatory rotating plate and channel flows in porous media using a fractional Burgers viscoelastic model

    Maqbool, Khadija; Anwar Bég, O.; Sohail, Ayesha; Idreesa, Shafaq

    2016-05-01

    The theoretical analysis of magnetohydrodynamic (MHD) incompressible flows of a Burgers fluid through a porous medium in a rotating frame of reference is presented. The constitutive model of a Burgers fluid is used based on a fractional calculus formulation. Hydrodynamic slip at the wall (plate) is incorporated and the fractional generalized Darcy model deployed to simulate porous medium drag force effects. Three different cases are considered: namely, the flow induced by a general periodic oscillation at a rigid plate, the periodic flow in a parallel plate channel and, finally, the Poiseuille flow. In all cases the plate(s) boundary(ies) are electrically non-conducting and a small magnetic Reynolds number is assumed, negating magnetic induction effects. The well-posed boundary value problems associated with each case are solved via Fourier transforms. Comparisons are made between the results derived with and without slip conditions. Four special cases are retrieved from the general fractional Burgers model, viz. Newtonian fluid, general Maxwell viscoelastic fluid, generalized Oldroyd-B fluid and the conventional Burgers viscoelastic model. Extensive interpretation of graphical plots is included. We study explicitly the influence of the wall slip on primary and secondary velocity evolution. The model is relevant to MHD rotating energy generators employing rheological working fluids.

  9. Exact Solutions of a Coupled Burgers System

    HUANG Ling

    2006-01-01

    The exact solutions of a new coupled Burgers system are studied in three different ways. The first type of solutions are found thanks to the coupled Burgers system possessing a simple single Burgers reduction. The second type of multiple soliton solutions are revealed via the decouple procedure. The third type of exact solutions are found by means of a prior ansatz and solutions of the heat conduction equation. Two different kinds of soliton fission phenomena of the model are discovered and a special type of completely elastic soliton collision without phase shift of the model is also displayed.

  10. The inviscid, compressible and rotational, 2D isotropic Burgers and pressureless Euler-Coriolis fluids: Solvable models with illustrations

    Choquard, Ph.; Vuffray, M.

    2014-10-01

    The coupling between dilatation and vorticity, two coexisting and fundamental processes in fluid dynamics (Wu et al., 2006, pp. 3, 6) is investigated here, in the simplest cases of inviscid 2D isotropic Burgers and pressureless Euler-Coriolis fluids respectively modeled by single vortices confined in compressible, local, inertial and global, rotating, environments. The field equations are established, inductively, starting from the equations of the characteristics solved with an initial Helmholtz decomposition of the velocity fields namely a vorticity free and a divergence free part (Wu et al., 2006, Sects. 2.3.2, 2.3.3) and, deductively, by means of a canonical Hamiltonian Clebsch like formalism (Clebsch, 1857, 1859), implying two pairs of conjugate variables. Two vector valued fields are constants of the motion: the velocity field in the Burgers case and the momentum field per unit mass in the Euler-Coriolis one. Taking advantage of this property, a class of solutions for the mass densities of the fluids is given by the Jacobian of their sum with respect to the actual coordinates. Implementation of the isotropy hypothesis entails a radial dependence of the velocity potentials and of the stream functions associated to the compressible and to the rotational part of the fluids and results in the cancellation of the dilatation-rotational cross terms in the Jacobian. A simple expression is obtained for all the radially symmetric Jacobians occurring in the theory. Representative examples of regular and singular solutions are shown and the competition between dilatation and vorticity is illustrated. Inspired by thermodynamical, mean field theoretical analogies, a genuine variational formula is proposed which yields unique measure solutions for the radially symmetric fluid densities investigated. We stress that this variational formula, unlike the Hopf-Lax formula, enables us to treat systems which are both compressible and rotational. Moreover in the one

  11. Sample Structure of Forced Burgers Turbulence

    Nakazawa, H.

    1981-05-01

    Burgers equation in the inviscid limit with Gaussian white noise type force is analyzed as a model for a class of forced Burgers turbulence problems in the light of a classical work of stochastic differential equations for total energy and total variation (in the space variable) of the field are derived. Significance of the quantity total variation and the prospects on the existence of the invariant measure are also discussed.

  12. Spontaneous Stochasticity and Anomalous Dissipation for Burgers Equation

    Eyink, Gregory L.; Drivas, Theodore D.

    2015-01-01

    We develop a Lagrangian approach to conservation-law anomalies in weak solutions of inviscid Burgers equation, motivated by previous work on the Kraichnan model of turbulent scalar advection. We show that the entropy solutions of Burgers possess Markov stochastic processes of (generalized) Lagrangian trajectories backward in time for which the Burgers velocity is a backward martingale. This property is shown to guarantee dissipativity of conservation-law anomalies for general convex functions of the velocity. The backward stochastic Burgers flows with these properties are not unique, however. We construct infinitely many such stochastic flows, both by a geometric construction and by the zero-noise limit of the Constantin-Iyer stochastic representation of viscous Burgers solutions. The latter proof yields the spontaneous stochasticity of Lagrangian trajectories backward in time for Burgers, at unit Prandtl number. It is conjectured that existence of a backward stochastic flow with the velocity as martingale is an admissibility condition which selects the unique entropy solution for Burgers. We also study linear transport of passive densities and scalars by inviscid Burgers flows. We show that shock solutions of Burgers exhibit spontaneous stochasticity backward in time for all finite Prandtl numbers, implying conservation-law anomalies for linear transport. We discuss the relation of our results for Burgers with incompressible Navier-Stokes turbulence, especially Lagrangian admissibility conditions for Euler solutions and the relation between turbulent cascade directions and time-asymmetry of Lagrangian stochasticity.

  13. Spontaneous Stochasticity and Anomalous Dissipation for Burgers Equation

    Eyink, Gregory L

    2014-01-01

    We develop a Lagrangian approach to conservation-law anomalies in weak solutions of inviscid Burgers equation, motivated by previous work on the Kraichnan model of turbulent scalar advection. We show that the entropy solutions of Burgers possess Markov stochastic processes of (generalized) Lagrangian trajectories backward in time for which the Burgers velocity is a backward martingale. This property is shown to guarantee dissipativity of conservation-law anomalies for general convex functions of the velocity. The backward stochastic Burgers flows with these properties are not unique, however. We construct infinitely many such stochastic flows, both by a geometric construction and by the zero-noise limit of the Constantin-Iyer stochastic representation of viscous Burgers solutions. The latter proof yields the spontaneous stochasticity of Lagrangian trajectories backward in time for Burgers, at unit Prandtl number. It is conjectured that existence of a backward stochastic flow with the velocity as martingale is...

  14. Simulation of seismic waves at the Earth crust (brittle-ductile transition based on the Burgers model

    J. M. Carcione

    2014-06-01

    Full Text Available The Earth crust presents two dissimilar rheological behaviours depending on the in-situ stress-temperature conditions. The upper, cooler, part is brittle while deeper zones are ductile. Seismic waves may reveal the presence of the transition but a proper characterization is required. We first obtain a stress–strain relation including the effects of shear seismic attenuation and ductility due to shear deformations and plastic flow. The anelastic behaviour is based on the Burgers mechanical model to describe the effects of seismic attenuation and steady-state creep flow. The shear Lamé constant of the brittle and ductile media depends on the in-situ stress and temperature through the shear viscosity, which is obtained by the Arrhenius equation and the octahedral stress criterion. The P- and S-wave velocities decrease as depth and temperature increase due to the geothermal gradient, an effect which is more pronounced for shear waves. We then obtain the P-S and SH equations of motion recast in the velocity-stress formulation, including memory variables to avoid the computation of time convolutions. The equations correspond to isotropic anelastic and inhomogeneous media and are solved by a direct grid method based on the Runge–Kutta time stepping technique and the Fourier pseudospectral method. The algorithm is tested with success against known analytical solutions for different shear viscosities. A realistic example illustrates the computation of surface and reverse-VSP synthetic seismograms in the presence of an abrupt brittle-ductile transition.

  15. Rational Solutions in a Coupled Burgers System

    HUANG Ling

    2006-01-01

    Three types of the rational solutions for a new coupled Burgers system are studied in detail in terms of the reduction and decoupled procedures. The first two types of rational solutions are singular and valid for one type of model parameter c>0, and another type of rational solutions is nonsingular at any type and valid for another type of model parameter c<0.

  16. Adhesive joint and composites modeling in SIERRA.

    Ohashi, Yuki; Brown, Arthur A.; Hammerand, Daniel Carl; Adolf, Douglas Brian; Chambers, Robert S.; Foulk, James W., III (.,; )

    2005-11-01

    Polymers and fiber-reinforced polymer matrix composites play an important role in many Defense Program applications. Recently an advanced nonlinear viscoelastic model for polymers has been developed and incorporated into ADAGIO, Sandia's SIERRA-based quasi-static analysis code. Standard linear elastic shell and continuum models for fiber-reinforced polymer-matrix composites have also been added to ADAGIO. This report details the use of these models for advanced adhesive joint and composites simulations carried out as part of an Advanced Simulation and Computing Advanced Deployment (ASC AD) project. More specifically, the thermo-mechanical response of an adhesive joint when loaded during repeated thermal cycling is simulated, the response of some composite rings under internal pressurization is calculated, and the performance of a composite container subjected to internal pressurization, thermal loading, and distributed mechanical loading is determined. Finally, general comparisons between the continuum and shell element approaches for modeling composites using ADAGIO are given.

  17. Symmetry study of the coupled Burgers system

    Lian Zengju [Department of Physics, Ningbo University, Ningbo 315211 (China); Lou, S.Y. [Department of Physics, Ningbo University, Ningbo 315211 (China); Department of Physics, Shanghai Jiao Tong University, Shanghai 200030 (China)

    2006-01-01

    The inverse of the recursion operator of a coupled Burgers equation is given explicitly. Three sets of infinitely many symmetries of the considered model are obtained by acting the recursion operator and it's inverse on the trivial symmetries, space translation, identity transformation and the scaling transformation respectively. These symmetries constitute an infinite dimensional Lie algebra.

  18. Symmetry study of the coupled Burgers system

    The inverse of the recursion operator of a coupled Burgers equation is given explicitly. Three sets of infinitely many symmetries of the considered model are obtained by acting the recursion operator and it's inverse on the trivial symmetries, space translation, identity transformation and the scaling transformation respectively. These symmetries constitute an infinite dimensional Lie algebra

  19. Interfacial adhesion of graphene by multiscale models

    Huang, Rui

    2014-01-01

    This article presents a multiscale study on adhesive interactions between graphene and its substrates. First, van der Waals (vdW) interactions between graphene and a SiO2 substrate are studied by first-principle density functional theory (DFT) calculations with dispersion corrections. It is found that the interaction strength is strongly influenced by changes of the SiO2 surface structures due to surface reactions with water. To scale up the model, molecular dynamics (MD) simulations are perf...

  20. Intermittency of Burgers' Turbulence

    Balkovsky, E; Kolokolov, I V; Lebedev, V

    1997-01-01

    We consider the tails of probability density function (PDF) for the velocity that satisfies Burgers equation driven by a Gaussian large-scale force. The saddle-point approximation is employed in the path integral so that the calculation of the PDF tails boils down to finding the special field-force configuration (instanton) that realizes the extremum of probability. For the PDFs of velocity and it's derivatives $u^{(k)} = \\partial_x^ku$, the general formula is found: $\\ln{\\cal P}(|u^{(k)}|) \\propto -(|u^{(k)}|/{\\rm Re}^k)^{3/(k+1)}$.

  1. Adhesive contact:from atomistic model to continuum model

    Fan Kang-Qi; Jia Jian-Yuan; Zhu Ying-Min; Zhang Xiu-Yan

    2011-01-01

    Two types of Lennard-Jones potential are widely used in modeling adhesive contacts. However, the relationships between the parameters of the two types of Lennard-Jones potential are not well defined. This paper employs a selfconsistent method to derive the Lennard-Jones surface force law from the interatomic Lennard-Jones potential with emphasis on the relationships between the parameters. The effect of using correct parameters in the adhesion models is demonstrated in single sphere-flat contact via continuum models and an atomistic model. Furthermore, the adhesion hysteresis behaviour is investigated, and the S-shaped force-distance relation is revealed by the atomistic model. It shows that the adhesion hysteresis loop is generated by the jump-to-contact and jump-off-contact, which are illustrated by the S-shaped force-distance curve.

  2. An explicit relaxation filtering framework based upon Perona-Malik anisotropic diffusion for shock capturing and subgrid scale modeling of Burgers turbulence

    Maulik, Romit

    2016-01-01

    In this paper, we introduce a relaxation filtering closure approach to account for subgrid scale effects in explicitly filtered large eddy simulations using the concept of anisotropic diffusion. We utilize the Perona-Malik diffusion model and demonstrate its shock capturing ability and spectral performance for solving the Burgers turbulence problem, which is a simplified prototype for more realistic turbulent flows showing the same quadratic nonlinearity. Our numerical assessments present the behavior of various diffusivity functions in conjunction with a detailed sensitivity analysis with respect to the free modeling parameters. In comparison to direct numerical simulation (DNS) and under-resolved DNS results, we find that the proposed closure model is efficient in the prevention of energy accumulation at grid cut-off and is also adept at preventing any possible spurious numerical oscillations due to shock formation under the optimal parameter choices. In contrast to other relaxation filtering approaches, it...

  3. Computational modeling of leukocyte adhesion cascade (LAC)

    Sarkar, Kausik

    2005-11-01

    In response to an inflammation in the body, leukocytes (white blood cell) interact with the endothelium (interior wall of blood vessel) through a series of steps--capture, rolling, adhesion and transmigration--critical for proper functioning of the immune system. We are numerically simulating this process using a Front-tracking finite-difference method. The viscoelastcity of the cell membrane, cytoplasm and nucleus are incorporated and allowed to change with time in response to the cell surface molecular chemistry. The molecular level forces due to specific ligand-receptor interactions are accounted for by stochastic spring-peeling model. Even though leukocyte rolling has been investigated through various models, the transitioning through subsequent steps, specifically firm adhesion and transmigration through endothelial layer, has not been modeled. The change of viscoelastic properties due to the leukocyte activation is observed to play a critical role in mediating the transition from rolling to transmigration. We will provide details of our approach and discuss preliminary results.

  4. Transient Growth in Stochastic Burgers Flows

    Poças, Diogo

    2015-01-01

    This study considers the problem of the extreme behavior exhibited by solutions to Burgers equation subject to stochastic forcing. More specifically, we are interested in the maximum growth achieved by the "enstrophy" (the Sobolev $H^1$ seminorm of the solution) as a function of the initial enstrophy $\\mathcal{E}_0$, in particular, whether in the stochastic setting this growth is different than in the deterministic case considered by Ayala & Protas (2011). This problem is motivated by questions about the effect of noise on the possible singularity formation in hydrodynamic models. The main quantities of interest in the stochastic problem are the expected value of the enstrophy and the enstrophy of the expected value of the solution. The stochastic Burgers equation is solved numerically with a Monte Carlo sampling approach. By studying solutions obtained for a range of optimal initial data and different noise magnitudes, we reveal different solution behaviors and it is demonstrated that the two quantities ...

  5. Multidimensional Potential Burgers Turbulence

    Boritchev, Alexandre

    2016-03-01

    We consider the multidimensional generalised stochastic Burgers equation in the space-periodic setting: partial {u}/partial t+(nabla f({u}) \\cdot nabla) {u}-ν Δ {u}= nabla η, quad t ≥ 0, {x} in{T}^d=({R}/ {Z})^d, under the assumption that u is a gradient. Here f is strongly convex and satisfies a growth condition, ν is small and positive, while η is a random forcing term, smooth in space and white in time. For solutions u of this equation, we study Sobolev norms of u averaged in time and in ensemble: each of these norms behaves as a given negative power of ν. These results yield sharp upper and lower bounds for natural analogues of quantities characterising the hydrodynamical turbulence, namely the averages of the increments and of the energy spectrum. These quantities behave as a power of the norm of the relevant parameter, which is respectively the separation ℓ in the physical space and the wavenumber k in the Fourier space. Our bounds do not depend on the initial condition and hold uniformly in {ν}. We generalise the results obtained for the one-dimensional case in [10], confirming the physical predictions in [4, 30]. Note that the form of the estimates does not depend on the dimension: the powers of {ν, |{{k}}|, ℓ} are the same in the one- and the multi-dimensional setting.

  6. Optimized Baxter model of protein solutions: electrostatics versus adhesion

    Prinsen, P.; Odijk, T.

    2004-01-01

    A theory is set up of spherical proteins interacting by screened electrostatics and constant adhesion, in which the effective adhesion parameter is optimized by a variational principle for the free energy. An analytical approach to the second virial coefficient is first outlined by balancing the repulsive electrostatics against part of the bare adhesion. A theory similar in spirit is developed at nonzero concentrations by assuming an appropriate Baxter model as the reference state. The first-...

  7. Exact Finite Difference Scheme and Nonstandard Finite Difference Scheme for Burgers and Burgers-Fisher Equations

    Lei Zhang; Lisha Wang; Xiaohua Ding

    2014-01-01

    We present finite difference schemes for Burgers equation and Burgers-Fisher equation. A new version of exact finite difference scheme for Burgers equation and Burgers-Fisher equation is proposed using the solitary wave solution. Then nonstandard finite difference schemes are constructed to solve two equations. Numerical experiments are presented to verify the accuracy and efficiency of such NSFD schemes.

  8. BOUNDARY CONTROL OF MKDV-BURGERS EQUATION

    TIAN Li-xin; ZHAO Zhi-feng; WANG Jing-feng

    2006-01-01

    The boundary control of MKdV-Burgers equation was considered by feedback control on the domain [0,1]. The existence of the solution of MKdV-Burgers equation with the feedback control law was proved. On the base, priori estimates for the solution was given. At last, the existence of the weak solution of MKdV-Burgers equation was proved and the global-exponential and asymptotic stability of the solution of MKdV-Burgers equation was given.

  9. Bønner og burgere

    Rytter, Mikkel

    2013-01-01

    Based on a number of burger incidents during ten days of itikaf at a Sufi astana (lodge) in Pakistan, this article discusses religious self-cultivation among Muslim pilgrims from Denmark. The focus on food and eating is not only used to discuss how religious brotherhoods and spiritual kinship are...

  10. Modeling and characterization of interfacial adhesion and fracture

    Yao, Qizhou

    2000-09-01

    The loss of interfacial adhesion is mostly seen in the failure of polymer adhesive joints. In addition to the intrinsic physical attraction across the interface, the interfacial adhesion strength is believed to highly depend on a number of factors, such as adhesive chemistry/structure, surface topology, fracture pattern, thermal and elastic mismatch across the interface. The fracture failure of an adhesive joint involves basically three aspects, namely, the intrinsic interfacial strength, the driving force for fracture and other energy dissipation. One may define the intrinsic interfacial strength as the maximum value of the intrinsic interfacial adhesion. The total work done by external forces to the component that contains the interface is partitioned into two parts. The first part is consumed by all other energy dissipation mechanisms (plasticity, heat generation, viscosity, etc.). The second part is used to debond the interface. This amount should equal to the intrinsic adhesion of the interface according to the laws of conservation of energy. It is clear that in order to understand the fundamental physics of adhesive joint failure, one must be able to characterize the intrinsic interfacial adhesion and be able to identify all the major energy dissipation mechanisms involved in the debonding process. In this study, both physical and chemical adhesion mechanisms were investigated for an aluminum-epoxy interface. The physical bonding energy was estimated by computing the Van de Waals forces across the interface. A hydration model was proposed and the associated chemical bonding energy was calculated through molecular simulations. Other energy dissipation mechanisms such as plasticity and thermal residual stresses were also identified and investigated for several four-point bend specimens. In particular, a micromechanics based model was developed to estimate the adhesion enhancement due to surface roughness. It is found that for this Al-epoxy system the major

  11. Standardised Models for Inducing Experimental Peritoneal Adhesions in Female Rats

    Bernhard Kraemer; Christian Wallwiener; Rajab, Taufiek K; Christoph Brochhausen; Markus Wallwiener; Ralf Rothmund

    2014-01-01

    Animal models for adhesion induction are heterogeneous and often poorly described. We compare and discuss different models to induce peritoneal adhesions in a randomized, experimental in vivo animal study with 72 female Wistar rats. Six different standardized techniques for peritoneal trauma were used: brushing of peritoneal sidewall and uterine horns (group 1), brushing of parietal peritoneum only (group 2), sharp excision of parietal peritoneum closed with interrupted sutures (group 3), isc...

  12. Viscous Instanton for Burgers' Turbulence

    Balkovsky, E.; Falkovich, G.; Kolokolov, I.; Lebedev, V.

    1996-01-01

    We consider the tails of probability density functions (PDF) for different characteristics of velocity that satisfies Burgers equation driven by a large-scale force. The saddle-point approximation is employed in the path integral so that the calculation of the PDF tails boils down to finding the special field-force configuration (instanton) that realizes the extremum of probability. We calculate high moments of the velocity gradient $\\partial_xu$ and find out that they correspond to the PDF w...

  13. Simulation of Cell Adhesion using a Particle Transport Model

    Chesnutt, Jennifer

    2005-11-01

    An efficient computational method for simulation of cell adhesion through protein binding forces is discussed. In this method, the cells are represented by deformable elastic particles, and the protein binding is represented by a rate equation. The method is first developed for collision and adhesion of two similar cells impacting on each other from opposite directions. The computational method is then applied in a particle-transport model for a cloud of interacting and colliding cells, each of which are represented by particles of finite size. One application might include red blood cells adhering together to form rouleaux, which are chains of red blood cells that are found in different parts of the circulatory system. Other potential applications include adhesion of platelets to a blood vessel wall or mechanical heart valve, which is a precursor of thrombosis formation, or adhesion of cancer cells to organ walls in the lymphatic, circulatory, digestive or pulmonary systems.

  14. On two models for charged particle systems: the cometary flow equation and the Burgers-Poisson system

    Two models for charged particle systems are considered. The first chapter treats a kinetic equation with a relaxation time model for wave-particle collisions in cometary flows. Similarly to the BGK-model of gas dynamics, it involves a projection onto the set of equilibrium distributions, nonlinearly dependent on moments of the distribution function. An earlier existence result is extended to bounded domains with reflecting boundaries and to initial conditions permitting vacuum regions. The long time behavior is investigated. Convergence on compact time intervals (shifted to infinity) to the set of equilibrium solutions is proven. All smooth equilibrium solutions are computed and classified according to their geometry. The subset of smooth equilibria satisfying boundary conditions is investigated. Finally, explicit solutions of the Euler equations for ideal gases are constructed as moments of equilibrium solutions. In the second chapter, a dispersive model equation is considered, which has been proposed by Whitham as a shallow water model, and which can also be seen as a caricature of two species Euler-Poisson problems. A number of formal properties as well as similarities to other dispersive equations is derived. A travelling wave analysis and some numerical tests are carried out. The equation features wave breaking in finite time. A local existence result for smooth solutions and a global existence result for weak entropy solutions is proved. Finally a small dispersion limit is carried out for situations where the solution of the limiting equation is smooth. (author)

  15. Convergence of Convectively Filtered Burgers Equation to the Entropy Solution of Inviscid Burgers Equation

    Norgard, Greg

    2008-01-01

    This document provides a proof that the solutions to Convectively Filtered Burgers equation, will converge to the entropy solution of Inviscid Burgers equation when certain restrictions are put on the initial conditions. It does so by first establishing convergence to a weak solution of Inviscid Burgers equation. That solution is then shown to be the entropy solution.

  16. Thermal inactivation of Salmonella spp. in pork burger patties.

    Gurman, P M; Ross, T; Holds, G L; Jarrett, R G; Kiermeier, A

    2016-02-16

    Predictive models, to estimate the reduction in Escherichia coli O157:H7 concentration in beef burgers, have been developed to inform risk management decisions; no analogous model exists for Salmonella spp. in pork burgers. In this study, "Extra Lean" and "Regular" fat pork minces were inoculated with Salmonella spp. (Salmonella 4,[5],12,i:-, Salmonella Senftenberg and Salmonella Typhimurium) and formed into pork burger patties. Patties were cooked on an electric skillet (to imitate home cooking) to one of seven internal temperatures (46, 49, 52, 55, 58, 61, 64 °C) and Salmonella enumerated. A generalised linear logistic regression model was used to develop a predictive model for the Salmonella concentration based on the internal endpoint temperature. It was estimated that in pork mince with a fat content of 6.1%, Salmonella survival will be decreased by -0.2407log10 CFU/g for a 1 °C increase in internal endpoint temperature, with a 5-log10 reduction in Salmonella concentration estimated to occur when the geometric centre temperature reaches 63 °C. The fat content influenced the rate of Salmonella inactivation (P=0.043), with Salmonella survival increasing as fat content increased, though this effect became negligible as the temperature approached 62 °C. Fat content increased the time required for patties to achieve a specified internal temperature (P=0.0106 and 0.0309 for linear and quadratic terms respectively), indicating that reduced fat pork mince may reduce the risk of salmonellosis from consumption of pork burgers. Salmonella serovar did not significantly affect the model intercepts (P=0.86) or slopes (P=0.10) of the fitted logistic curve. This predictive model can be applied to estimate the reduction in Salmonella in pork burgers after cooking to a specific endpoint temperature and hence to assess food safety risk. PMID:26686598

  17. Bacterial Adhesion to Hexadecane (Model NAPL)-Water Interfaces

    Ghoshal, S.; Zoueki, C. R.; Tufenkji, N.

    2009-05-01

    The rates of biodegradation of NAPLs have been shown to be influenced by the adhesion of hydrocarbon- degrading microorganisms as well as their proximity to the NAPL-water interface. Several studies provide evidence for bacterial adhesion or biofilm formation at alkane- or crude oil-water interfaces, but there is a significant knowledge gap in our understanding of the processes that influence initial adhesion of bacteria on to NAPL-water interfaces. In this study bacterial adhesion to hexadecane, and a series of NAPLs comprised of hexadecane amended with toluene, and/or with asphaltenes and resins, which are the surface active fractions of crude oils, were examined using a Microbial Adhesion to Hydrocarbons (MATH) assay. The microorganisms employed were Mycobacterium kubicae, Pseudomonas aeruginosa and Pseudomonas putida, which are hydrocarbon degraders or soil microorganisms. MATH assays as well as electrophoretic mobility measurements of the bacterial cells and the NAPL droplet surfaces in aqueous solutions were conducted at three solution pHs (4, 6 and 7). Asphaltenes and resins were shown to generally decrease microbial adhesion. Results of the MATH assay were not in qualitative agreement with theoretical predictions of bacteria- hydrocarbon interactions based on the extended Derjaguin-Landau-Verwey-Overbeek (XDLVO) model of free energy of interaction between the cell and NAPL droplets. In this model the free energy of interaction between two colloidal particles is predicted based on electrical double layer, van der Waals and hydrophobic forces. It is likely that the steric repulsion between bacteria and NAPL surfaces, caused by biopolymers on bacterial surfaces and aphaltenes and resins at the NAPL-water interface contributed to the decreased adhesion compared to that predicted by the XDLVO model.

  18. Effects of a Temperature-Sensitive, Anti-Adhesive Agent on the Reduction of Adhesion in a Rabbit Laminectomy Model

    Park, Jeong Woo; Bak, Koang Hum; Cho, Tae Koo; Chun, Hyoung-Joon; Ryu, Je Il

    2016-01-01

    Objective A common cause of failure in laminectomy surgery is when epidural, peridural, or perineural adhesion occurs postoperatively. The purpose of this study is to examine the efficacy of a temperature-sensitive, anti-adhesive agent (TSAA agent), Guardix-SG®, as a mechanical barrier for the prevention or reduction of peridural scar adhesion in a rabbit laminectomy model. Methods Twenty-six mature rabbits were used for this study. Each rabbit underwent two separate laminectomies at lumbar v...

  19. Standardised Models for Inducing Experimental Peritoneal Adhesions in Female Rats

    Bernhard Kraemer

    2014-01-01

    Full Text Available Animal models for adhesion induction are heterogeneous and often poorly described. We compare and discuss different models to induce peritoneal adhesions in a randomized, experimental in vivo animal study with 72 female Wistar rats. Six different standardized techniques for peritoneal trauma were used: brushing of peritoneal sidewall and uterine horns (group 1, brushing of parietal peritoneum only (group 2, sharp excision of parietal peritoneum closed with interrupted sutures (group 3, ischemic buttons by grasping the parietal peritoneum and ligating the base with Vicryl suture (group 4, bipolar electrocoagulation of the peritoneum (group 5, and traumatisation by electrocoagulation followed by closure of the resulting peritoneal defect using Vicryl sutures (group 6. Upon second look, there were significant differences in the adhesion incidence between the groups (P<0.01. Analysis of the fraction of adhesions showed that groups 2 (0% and 5 (4% were significantly less than the other groups (P<0.01. Furthermore, group 6 (69% was significantly higher than group 1 (48% (P<0.05 and group 4 (47% (P<0.05. There was no difference between group 3 (60% and group 6 (P=0.2. From a clinical viewpoint, comparison of different electrocoagulation modes and pharmaceutical adhesion barriers is possible with standardised models.

  20. Modified non-linear Burgers' equations and cosmic ray shocks

    Zank, G. P.; Webb, G. M.; Mckenzie, J. F.

    1988-01-01

    A reductive perturbation scheme is used to derive a generalized non-linear Burgers' equation, which includes the effects of dispersion, in the long wavelength regime for the two-fluid hydrodynamical model used to describe cosmic ray acceleration by the first-order Fermi process in astrophysical shocks. The generalized Burger's equation is derived for both relativistic and non-relativistic cosmic ray shocks, and describes the time evolution of weak shocks in the theory of diffusive shock acceleration. The inclusion of dispersive effects modifies the phase velocity of the shock obtained from the lower order non-linear Burger's equation through the introduction of higher order terms from the long wavelength dispersion equation. The travelling wave solution of the generalized Burgers' equation for a single shock shows that larger cosmic ray pressures result in broader shock transitions. The results for relativistic shocks show a steepening of the shock as the shock speed approaches the relativistic cosmic ray sound speed. The dependence of the shock speed on the cosmic ray pressure is also discussed.

  1. The adhesion model considering capillarity for gecko attachment system.

    Kim, Tae Wan; Bhushan, Bharat

    2008-03-01

    Geckos make use of approximately a million microscale hairs (setae) that branch off into hundreds of nanoscale spatulae to cling to different smooth and rough surfaces and detach at will. This hierarchical surface construction gives the gecko the adaptability to create a large real area of contact with surfaces. It is known that van der Waals force is the primary mechanism used to adhere to surfaces, and capillary force is a secondary effect that can further increase adhesive force. To investigate the effects of capillarity on gecko adhesion, we considered the capillary force as well as the solid-to-solid interaction. The capillary force expressed in terms of elliptical integral is calculated by numerical method to cope with surfaces with a wide range of contact angles. The adhesion forces exerted by a single gecko spatula in contact with planes with different contact angles for various relative humidities are calculated, and the contributions of capillary force to total adhesion force are evaluated. The simulation results are compared with experimental data. Finally, using the three-level hierarchical model recently developed to simulate a gecko seta contacting with random rough surface, the effect of the relative humidity and the hydrophobicity of surface on the gecko adhesion is investigated. PMID:17594962

  2. Linear stability of shock waves for the Schrodinger-Burgers system

    Amorim, Paulo; Figueira, Mario; LeFloch, Philippe G

    2012-01-01

    We investigate a system coupling the nonlinear Schrodinger equation and the inviscid Burgers equation, which models interactions between short and long waves (for instance in fluids). Well-posedness for the associated Cauchy problem remains a difficult open problem and so we tackle it here via a linearization technique. We establish a linearized stability theorem for the Schrodinger-Burgers system when the reference solution is an entropy-satisfying shock wave to Burgers equation. Our proof is based on suitable energy estimates and on properties of hyperbolic equations with discontinuous coefficients. Numerical experiments support and expand our theoretical results.

  3. Direct adhesive measurements between wood biopolymer model surfaces.

    Gustafsson, Emil; Johansson, Erik; Wågberg, Lars; Pettersson, Torbjörn

    2012-10-01

    For the first time the dry adhesion was measured for an all-wood biopolymer system using Johnson-Kendall-Roberts (JKR) contact mechanics. The polydimethylsiloxane hemisphere was successfully surface-modified with a Cellulose I model surface using layer-by-layer assembly of nanofibrillated cellulose and polyethyleneimine. Flat surfaces of cellulose were equally prepared on silicon dioxide substrates, and model surfaces of glucomannan and lignin were prepared on silicon dioxide using spin-coating. The measured work of adhesion on loading and the adhesion hysteresis was found to be very similar between cellulose and all three wood polymers, suggesting that the interaction between these biopolymers do not differ greatly. Surface energy calculations from contact angle measurements indicated similar dispersive surface energy components for the model surfaces. The dispersive component was dominating the surface energy for all surfaces. The JKR work of adhesion was lower than that calculated from contact angle measurements, which partially can be ascribed to surface roughness of the model surfaces and overestimation of the surface energies from contact angle determinations. PMID:22924973

  4. Oscillating flow of a Burgers' fluid in a pipe

    An analysis is made to see the influences of Hall current on the flow of a Burgers' fluid. The velocity field corresponding to flow in a pipe is determined. The closed form analytical solutions for several Newtonian and non-Newtonian fluid models can be obtained from the present analysis as the limiting cases. The purpose of this work is twofold. Firstly, to investigate the oscillating flow in a pipe using Burgers? fluid model. Secondly, to see the effects of Hall current on the velocity field. The flow in a pipe is induced due to imposition of an oscillating pressure gradient. An exact analytical solution to the governing problem is given using the Fourier transform technique. The obtained expression for the velocity field shows that there are pronounced effects of Hall and rheological parameters. The considered fluid model is a viscoelastic model and has been used to characterize food products such as cheese, soil, asphalt and asphalt mixes etc. (author)

  5. The relativistic Burgers equation on a FLRW background and its finite volume approximation

    Ceylan, Tuba; LeFloch, Philippe G.; Okutmustur, Baver

    2015-01-01

    A relativistic generalization of the inviscid Burgers equation was proposed by LeFloch, Makhlof, and Okutmustur and then investigated on a Schwarzschild background. Here, we extend their analysis to a Friedmann-Lemaitre-Robertson-Walker (FLRW) background. This problem is more challenging due to the existence of non-trivial spatially homogeneous solutions. First, we derive the relativistic Burgers model of interest and determine its spatially homogeneous solutions. Second, we design a numerica...

  6. The relativistic Burgers equation on a FLRW background and its finite volume approximation

    Ceylan, Tuba; LeFloch, Philippe G.; Okutmustur, Baver

    2015-01-01

    A relativistic generalization of the inviscid Burgers equation was proposed by LeFloch, Makhlof, and Okutmustur and then investigated on a Schwarzschild background. Here, we extend their analysis to a Friedmann–Lemaitre–Robertson–Walker (FLRW) background. This problem is more challenging due to the existence of non-trivial spatially homogeneous solutions. First, we derive the relativistic Burgers model of interest and determine its spatially homogeneous solutions. Second, we design a numerica...

  7. Convergence of a random walk method for the Burgers equation

    In this paper we consider a random walk algorithm for the solution of Burgers' equation. The algorithm uses the method of fractional steps. The non-linear advection term of the equation is solved by advecting ''fluid'' particles in a velocity field induced by the particles. The diffusion term of the equation is approximated by adding an appropriate random perturbation to the positions of the particles. Though the algorithm is inefficient as a method for solving Burgers' equation, it does model a similar method, the random vortex method, which has been used extensively to solve the incompressible Navier-Stokes equations. The purpose of this paper is to demonstrate the strong convergence of our random walk method and so provide a model for the proof of convergence for more complex random walk algorithms; for instance, the random vortex method without boundaries

  8. Slow Burgers Vortices in Hot Conformal Fluids

    Evslin, Jarah

    2011-01-01

    The quintessential vortex solution in (3+1)-dimensional nonrelativistic, incompressible fluid mechanics is the Burgers vortex. We show that, in a finite domain, conformal fluids also admit hot vortex solutions with everywhere nonrelativistic speeds. These are identical to Burgers' solution, except that their radius is reduced by a factor of 2/sqrt(3). A rough calculation indicates that at RHIC these vortices are indeed smaller than the fireball itself during thermalization. Similarly to the B...

  9. Preliminary group classification for generalized inviscid Burger's equation

    Mahdipour-Shirayeh, A

    2010-01-01

    Preliminary group classification for a class of generalized inviscid Burger's equations in the general form $u_t+g(x, u)u_x = f(x, u)$ is given and additional equivalence transformations are found. Adduced results complete and essentially generalize recent works on the subject . A number of new interesting nonlinear invariant models which have non-trivial invariance algebras are obtained. The result of the work is a wide class of equations summarized in table form.

  10. Organizational Communication and Workforce Diversity Case Company: Burger King, Finland

    Raqib, Maliha

    2015-01-01

    The purpose of this Bachelor’s thesis is to examine the internal work process related communication of Burger King, Finland. The main focus of this thesis is to assess the current communication flow and recognize communication weak points. Therefore, three investigative questions were formulated to understand the phenomena and provide development suggestions for further communication progress. The theoretical framework consists of theories related to basic human communication model, organ...

  11. Advances in modeling and design of adhesively bonded systems

    Kumar, S

    2013-01-01

    The book comprehensively charts a way for industry to employ adhesively bonded joints to make systems more efficient and cost-effective Adhesively bonded systems have found applications in a wide spectrum of industries (e.g., aerospace, electronics, construction, ship building, biomedical, etc.) for a variety of purposes. Emerging adhesive materials with improved mechanical properties have allowed adhesion strength approaching that of the bonded materials themselves. Due to advances in adhesive materials and the many potential merits that adhesive bonding offers, adhesive bonding has replac

  12. Viscous instanton for Burgers' turbulence

    Balkovsky, E; Kolokolov, I V; Lebedev, V

    1996-01-01

    We consider the tails of probability density functions (PDF) for different characteristics of velocity that satisfies Burgers equation driven by a large-scale force. The saddle-point approximation is employed in the path integral so that the calculation of the PDF tails boils down to finding the special field-force configuration (instanton) that realizes the extremum of probability. We calculate high moments of the velocity gradient \\partial_xu and find out that they correspond to the PDF with \\ln[{\\cal P}(\\partial_xu)]\\propto-(-\\partia l_xu/{\\rm Re})^{3/2} where {\\rm Re} is the Reynolds number. That stretched exponential form is valid for negative \\partial_xu with the modulus much larger than its root-mean-square (rms) value. The respective tail of PDF for negative velocity differences w is steeper than Gaussian, \\ln{\\cal P}(w)\\sim-(w/u_{\\rm rms})^3, as well as single-point velocity PDF \\ln{\\cal P}(u)\\sim-(|u|/u_{\\rm rms})^3. For high velocity derivatives u^{(k)}=\\partial_x^ku, the general formula is found: ...

  13. A mechanical model of biomimetic adhesive pads with tilted and hierarchical structures

    Schargott, M [Institute of Mechanics, Technische Universitaet Berlin, Strd 17 Juni 135, 10623 Berlin (Germany)], E-mail: martin.schargott@tu-berlin.de

    2009-06-01

    A 3D model for hierarchical biomimetic adhesive pads is constructed. It is based on the main principles of the adhesive pads of the Tokay gecko and consists of hierarchical layers of vertical or tilted beams, where each layer is constructed in such a way that no cohesion between adjacent beams can occur. The elastic and adhesive properties are calculated analytically and numerically. For the adhesive contact on stochastically rough surfaces, the maximum adhesion force increases with increasing number of hierarchical layers. Additional calculations show that the adhesion force also depends on the height spectrum of the rough surface.

  14. The adhesion model as a field theory for cosmological clustering

    The adhesion model has been proposed in the past as an improvement of the Zel'dovich approximation, providing a good description of the formation of the cosmic web. We recast the model as a field theory for cosmological large scale structure, adding a stochastic force to account for power generated from very short, highly non-linear scales that is uncorrelated with the initial power spectrum. The dynamics of this Stochastic Adhesion Model (SAM) is reminiscent of the well known Kardar-Parisi-Zhang equation with the difference that the viscosity and the noise spectrum are time dependent. Choosing the viscosity proportional to the growth factor D restricts the form of noise spectrum through a 1-loop renormalization argument. For this choice, the SAM field theory is renormalizable to one loop. We comment on the suitability of this model for describing the non-linear regime of the CDM power spectrum and its utility as a relatively simple approach to cosmological clustering

  15. Adhesion of Aeromonas sp. to cell lines used as models for intestinal adhesion.

    Kirov, S M; Hayward, L. J.; Nerrie, M. A.

    1995-01-01

    Adhesion to HEp-2 cells has been shown to correlate with enteropathogenicity for Aeromonas species. Such adhesion is thought to reflect the ability of strains to adhere to human intestinal enterocytes, although HEp-2 cells are not of intestinal origin. In this study strains of Aeromonas veronii biotype sobria isolated from various sources were investigated in parallel assays for their ability to adhere to HEp-2 cells and to an intestinal cell line (Caco-2). Quantitative assays showed identica...

  16. Generalized Cole–Hopf transformations for generalized Burgers equations

    B Mayil Vaganan; E Emily Priya

    2015-11-01

    A detailed review of the invention of Cole–Hopf transformations for the Burgers equation and all the subsequent works which include generalizations of the Burgers equation and the corresponding developments in Cole–Hopf transformations are documented.

  17. Forced Burgers Turbulence in 3-Dimensions

    Davoudi, J; Rahimi-Tabar, M R

    1999-01-01

    We investigate non-perturbative results of inviscid forced Burgers equation supplemented to continuity equation in three-dimensions. The exact two-point correlation function of density is calculated in three-dimensions. The two-point correlator $$ behaves as $ |{\\bf {x_1 - x_2}}|^{-\\alpha_3}$ and in the universal region $\\alpha_3 = 2 + universal region we show that the angular dependence of the velocity correlation function satisfies the same equation, which is found in the instanton approach by Gurarie and Migdal {[Phys. Rev. E {\\bf 54}, 4908 (1996)]}. The tail of the velocity increments is also found to behave as drive a Kramers-Moyal equation governing the evolution of the probability density function (PDF) of longitudinal velocity increments for three dimensional Burgers turbulence. In this region we prove Yakhot's conjecture {[Phys. Rev. E {\\bf 57}, 1737 (1998)]} for the equation of PDF for three dimensional Burgers turbulence. We also derive the intermittency exponents for the longitudinal structure fun...

  18. Algebraic dynamics solution and algebraic dynamics algorithm of Burgers equations

    2008-01-01

    Algebraic dynamics solution and algebraic dynamics algorithm of nonlinear partial differential evolution equations in the functional space are applied to Burgers equation. The results indicate that the approach is effective for analytical solutions to Burgers equation, and the algorithm for numerical solutions of Burgers equation is more stable, with higher precision than other existing finite difference algo-rithms.

  19. Axisymmetric Finite Element Modeling of Adhesive Joint Between a Laminated Composite and Metal Cylinder

    Talbot, Casey A.

    2011-01-01

    In order to incorporate fiber-reinforced composite materials in space structures, adhesive joining techniques are required. Because analytical models have a hard time capturing the complex stress state inherent to adhesively joining dissimilar materials, a different modeling technique was deemed necessary. A two-dimensional axisymmetric finite element model capable of capturing the three-dimensional stress state of cylindrical adhesive joints was developed. In order to rigorously validate the...

  20. Exact solution of generalized inviscid Burgers' equation

    Nadjafikhah, Mehdi

    2009-01-01

    Let $f,g:{\\Bbb R}\\to{\\Bbb R}$ be integrable functions, $f$ nowhere zero, and $\\phi (u)=\\int du/f(u)$ be invertible. An exact solution to the generalized nonhomogeneous inviscid Burgers' equation $u_t+g(u).u_x=f(u)$ is given, by quadratures.

  1. Transient flows of a Burgers' fluid

    An analysis is performed to develop the analytical solutions for some unsteady magnetohydrodynamic (MHD) flows of a Burgers' fluid between two plates. A uniform magnetic field is applied transversely to the fluid motion. The exact solutions are given for three problems. Results for the velocity fields are discussed and compared with the flows of Oldroyd-B, Maxwell, second grade and Newtonian fluids. (author)

  2. Structure of Shocks in Burgers Turbulencewith Stable Noise Initial Data

    Bertoin, Jean

    Burgers equation can be used as a simplified model for hydrodynamic turbulence. The purpose of this paper is to study the structure of the shocks for the inviscid equation in dimension 1 when the initial velocity is given by a stable Lévy noise with index α∈ (1/2,2]. We prove that Lagrangian regular points exist (i.e. there are fluid particles that have not participated in shocks at any time between 0 and t) if and only if α0$, there are fluid particles in any non-empty open interval.

  3. Optimized Baxter model of protein solutions: electrostatics versus adhesion

    Prinsen, P.; Odijk, T.

    2004-01-01

    A theory is set up of spherical proteins interacting by screened electrostatics and constant adhesion, in which the effective adhesion parameter is optimized by a variational principle for the free energy. An analytical approach to the second virial coefficient is first outlined by balancing the rep

  4. An innovative wheel–rail contact model for railway vehicles under degraded adhesion conditions

    Meli, E., E-mail: enrico.meli@unifi.it; Ridolfi, A., E-mail: a.ridolfi@unifi.it [University of Florence, Department of Industrial Engineering (Italy)

    2015-03-15

    The accurate modelling of the wheel–rail contact plays a fundamental role in the railway field since the contact forces heavily affect the vehicle dynamics, the wear of the contact surfaces and the vehicle safety. Concerning the wheel–rail contact, an important open problem is represented by the degraded adhesion. A realistic adhesion model is quite difficult to obtain because of the complex and highly non-linear behaviour of the adhesion coefficient and the presence of external unknown contaminants (the third body); this is especially true when degraded adhesion and large sliding between the wheel and rail contact surfaces occur.In this work the authors present an adhesion model particularly developed to describe degraded adhesion conditions. The new approach will have to be suitable to be employed within the wheel–rail contact models typical of the multibody applications. In other words, the contact model, comprising the new adhesion model, will have to guarantee a good accuracy and, at the same time, a high numerical efficiency to be implemented directly online inside the general multibody model of the vehicles (e.g. in Matlab-Simulink or Simpack environments) ( www.mathworks.com http://www.mathworks.com , 2012; www.simpack.com http://www.simpack.com , 2012).The model analysed in the paper is based on some of the main phenomena characterising the degraded adhesion, such as large sliding at the contact interface, high energy dissipation, the consequent cleaning effect on the contact surfaces and the final adhesion recovery due to the removal of external unknown contaminants.The adhesion model has been validated because of the experimental data provided by Trenitalia S.p.A. coming from on-track tests performed in Velim (Czech Republic). The tests have been carried out on a straight railway track under degraded adhesion conditions with the railway vehicle UIC-Z1 equipped with a fully-working Wheel Slide Protection (WSP) system.The validation highlighted the

  5. An innovative wheel–rail contact model for railway vehicles under degraded adhesion conditions

    The accurate modelling of the wheel–rail contact plays a fundamental role in the railway field since the contact forces heavily affect the vehicle dynamics, the wear of the contact surfaces and the vehicle safety. Concerning the wheel–rail contact, an important open problem is represented by the degraded adhesion. A realistic adhesion model is quite difficult to obtain because of the complex and highly non-linear behaviour of the adhesion coefficient and the presence of external unknown contaminants (the third body); this is especially true when degraded adhesion and large sliding between the wheel and rail contact surfaces occur.In this work the authors present an adhesion model particularly developed to describe degraded adhesion conditions. The new approach will have to be suitable to be employed within the wheel–rail contact models typical of the multibody applications. In other words, the contact model, comprising the new adhesion model, will have to guarantee a good accuracy and, at the same time, a high numerical efficiency to be implemented directly online inside the general multibody model of the vehicles (e.g. in Matlab-Simulink or Simpack environments) ( www.mathworks.com http://www.mathworks.com , 2012; www.simpack.com http://www.simpack.com , 2012).The model analysed in the paper is based on some of the main phenomena characterising the degraded adhesion, such as large sliding at the contact interface, high energy dissipation, the consequent cleaning effect on the contact surfaces and the final adhesion recovery due to the removal of external unknown contaminants.The adhesion model has been validated because of the experimental data provided by Trenitalia S.p.A. coming from on-track tests performed in Velim (Czech Republic). The tests have been carried out on a straight railway track under degraded adhesion conditions with the railway vehicle UIC-Z1 equipped with a fully-working Wheel Slide Protection (WSP) system.The validation highlighted the

  6. Mesoscopic Modeling of Blood Clotting: Coagulation Cascade and Platelets Adhesion

    Yazdani, Alireza; Li, Zhen; Karniadakis, George

    2015-11-01

    The process of clot formation and growth at a site on a blood vessel wall involve a number of multi-scale simultaneous processes including: multiple chemical reactions in the coagulation cascade, species transport and flow. To model these processes we have incorporated advection-diffusion-reaction (ADR) of multiple species into an extended version of Dissipative Particle Dynamics (DPD) method which is considered as a coarse-grained Molecular Dynamics method. At the continuum level this is equivalent to the Navier-Stokes equation plus one advection-diffusion equation for each specie. The chemistry of clot formation is now understood to be determined by mechanisms involving reactions among many species in dilute solution, where reaction rate constants and species diffusion coefficients in plasma are known. The role of blood particulates, i.e. red cells and platelets, in the clotting process is studied by including them separately and together in the simulations. An agonist-induced platelet activation mechanism is presented, while platelets adhesive dynamics based on a stochastic bond formation/dissociation process is included in the model.

  7. Dynamic Transitions of Generalized Burgers Equation

    Li, Limei; Ong, Kiah Wah

    2016-03-01

    In this article, we study the dynamic transition for the one dimensional generalized Burgers equation with periodic boundary condition. The types of transition are dictated by the sign of an explicitly given parameter b, which is derived using the dynamic transition theory developed by Ma and Wang (Phase transition dynamics. Springer, New York, 2014). The rigorous result demonstrates clearly the types of dynamics transition in terms of length scale l, dispersive parameter δ and viscosity ν.

  8. Decaying Turbulence in the Generalised Burgers Equation

    Boritchev, Alexandre

    2014-10-01

    We consider the generalised Burgers equation where f is strongly convex and ν is small and positive. We obtain sharp estimates for Sobolev norms of u (upper and lower bounds differ only by a multiplicative constant). Then, we obtain sharp estimates for the dissipation length scale and the small-scale quantities which characterise the decaying Burgers turbulence, i.e., the structure functions and the energy spectrum. The proof uses a quantitative version of an argument by Aurell et al. (J Fluid Mech 238:467-486, 1992). Note that we are dealing with decaying, as opposed to stationary turbulence. Thus, our estimates are not uniform in time. However, they hold on a time interval [ T 1, T 2], where T 1 and T 2 depend only on f and the initial condition, and do not depend on the viscosity. These results allow us to obtain a rigorous theory of the one-dimensional Burgers turbulence in the spirit of Kolmogorov's 1941 theory. In particular, we obtain two results which hold in the inertial range. On one hand, we explain the bifractal behaviour of the moments of increments, or structure functions. On the other hand, we obtain an energy spectrum of the form k -2. These results remain valid in the inviscid limit.

  9. Qualitative improvement of low meat beef burger using Aloe vera.

    Soltanizadeh, Nafiseh; Ghiasi-Esfahani, Hossein

    2015-01-01

    Low meat beef burgers have found their niche in the food markets in developing countries because of their lower price. However, these burgers still lack an acceptable quality. This study investigates the effects of different concentrations of Aloe vera on the quality of this food product. For this purpose, beef burgers were produced with 0%, 1%, 3%, and 5% Aloe vera and the changes in their cooking parameters, lipid oxidation, texture, and appeal to consumers over 7days of refrigerated storage were evaluated. Results indicate that Aloe vera contributed to some extent to decreased cooking loss and diameter reduction in the burgers. Increased concentrations of Aloe vera led to improvements in the water absorption and texture of the burgers as well as their lipid stability. However, a concentration level of 3% led to the most acceptability of the product to the panelists. Finally, it was found that Aloe vera acts as a hydrocolloid and improves the quality of burgers. PMID:25282702

  10. Moyal noncommutative integrability and the Burgers-KdV mapping

    The Moyal momentum algebra, is once again used to discuss some important aspects of NC integrable models and 2d conformal field theories. Among the results presented, we set up algebraic structures and makes useful convention notations leading to extract non trivial properties of the Moyal momentum algebra. We study also the Lax pair building mechanism for particular examples namely, the noncommutative KdV and Burgers systems. We show in a crucial step that these two systems are mapped to each other through the following crucial mapping ∂t2 → ∂t3 ≡ ∂t2∂x + α∂x3. This makes a strong constraint on the NC Burgers system which corresponds to linearizing its associated differential equation. From the CFT's point of view, this constraint equation is nothing but the analogue of the conservation law of the conformal current. We believe that the considered mapping might help to bring new insights towards understanding the integrability of noncommutative 2d-systems. (author)

  11. A Spectral Adaptive Mesh Refinement Method for the Burgers equation

    Nasr Azadani, Leila; Staples, Anne

    2013-03-01

    Adaptive mesh refinement (AMR) is a powerful technique in computational fluid dynamics (CFD). Many CFD problems have a wide range of scales which vary with time and space. In order to resolve all the scales numerically, high grid resolutions are required. The smaller the scales the higher the resolutions should be. However, small scales are usually formed in a small portion of the domain or in a special period of time. AMR is an efficient method to solve these types of problems, allowing high grid resolutions where and when they are needed and minimizing memory and CPU time. Here we formulate a spectral version of AMR in order to accelerate simulations of a 1D model for isotropic homogenous turbulence, the Burgers equation, as a first test of this method. Using pseudo spectral methods, we applied AMR in Fourier space. The spectral AMR (SAMR) method we present here is applied to the Burgers equation and the results are compared with the results obtained using standard solution methods performed using a fine mesh.

  12. Effects of a Temperature-Sensitive, Anti-Adhesive Agent on the Reduction of Adhesion in a Rabbit Laminectomy Model

    Park, Jeong Woo; Cho, Tae Koo; Chun, Hyoung-Joon; Ryu, Je Il

    2016-01-01

    Objective A common cause of failure in laminectomy surgery is when epidural, peridural, or perineural adhesion occurs postoperatively. The purpose of this study is to examine the efficacy of a temperature-sensitive, anti-adhesive agent (TSAA agent), Guardix-SG®, as a mechanical barrier for the prevention or reduction of peridural scar adhesion in a rabbit laminectomy model. Methods Twenty-six mature rabbits were used for this study. Each rabbit underwent two separate laminectomies at lumbar vertebrae L3 and L6, left empty (the control group) and applied 2 mL of the TSAA agent (the experimental group), respectively. Invasive scar formation or inflammation after laminectomy was quantitatively evaluated by measuring the thickness of the dura, the distance from the surface of dura to the scar tissues, the number of inflammatory cells in the scar tissues at the laminectomy site, and the concentration of collagen in histological sections. Results At 6 weeks postsurgery, the dura was significantly thinner and the distance from the surface of dura to the scar tissues was greater in the experimental group than in the control group (p=0.04 and p=0.01). The number of inflammatory cells was not significantly different in the two groups (p=0.08), although the mean number of inflammatory cells was relatively lower in the experimental group than in the control group. Conclusion The current study suggests that the TSAA agent, Guardix-SG®, could be useful as an interpositional physical barrier after laminectomy for the prevention or reduction of adhesion. PMID:27226857

  13. Evaluation of explicit and implicit LES closures for Burgers turbulence

    Maulik, Romit

    2016-01-01

    In this work, we perform an aposteriori error analysis on implicit and explicit large eddy simulation closure models for solving the Burgers turbulence problem. Our closure modeling efforts include both functional and structural models equipped with various low-pass filters. We introduce discrete binomial smoothing filters and an enhanced version of the Van Cittert algorithm to accelerate the convergence of approximate deconvolution processes including regularization and relaxation filtering approaches. Our implicit modeling efforts consist of various high-order schemes including compact and non-compact fifth-order upwind schemes as well as weighted essential non-oscillatory (WENO) and compact reconstructed WENO (CRWENO) schemes, and the resulting schemes are shown to effectively converge to the direct numerical simulation (DNS) for increasing resolutions. Comparing with DNS and underresolved DNS computations, our numerical assessments illustrate the ability of these methods to capture the energy content near...

  14. Model for probing membrane-cortex adhesion by micropipette aspiration and fluctuation spectroscopy

    Alert, Ricard; Casademunt, Jaume; Brugués, Jan; Sens, Pierre

    2016-01-01

    We propose a model for membrane-cortex adhesion that couples membrane deformations, hydrodynamics, and kinetics of membrane-cortex ligands. In its simplest form, the model gives explicit predictions for the critical pressure for membrane detachment and for the value of adhesion energy. We show that these quantities exhibit a significant dependence on the active acto-myosin stresses. The model provides a simple framework to access quantitative information on cortical activity by means of micro...

  15. A Computational Model of Soil Adhesion and Resistance for a Non-smooth Bulldozing Plate

    Shi Wei-ping; Ren Lu-quan; Tian Li-mei

    2005-01-01

    Adhesive forces exist between soil and the surfaces of soil-engaging components; they increase working resistance and energy consumption. This paper tries to find an approach to reduce the adhesion and resistance of bulldozing plate. A simplified mechanical model of adhesion and resistance between soil and a non-smooth bulldozing plate is proposed. The interaction force between moist soil and a non-smooth bulldozing plate is analyzed. The pressure and friction distribution on the bulldozing plate are computed, and the anti-adhesive effect of a corrugated bulldozing plate is simulated numerically.Numerical results show that the wavy bulldozing plate achieves an effective drag reduction in moist soil. The optimal wavy shape of the corrugated bulldozing plate with the minimal resistance is designed. The basic principle of reducing soil adhesion of the non-smooth surface is discovered.

  16. Adhesive behaviour of gecko-inspired nanofibrillar arrays: combination of experiments and finite element modelling

    A polypropylene nanofibrillar array was successfully fabricated by template-assisted nanofabrication strategy. Adhesion properties of this gecko-inspired structure were studied through two parallel and independent approaches: experiments and finite element simulations. Experimental results show relatively good normal adhesion, but accompanied by high preloads. The interfacial adhesion was modelled by effective spring elements with piecewise-linear constitution. The effective elasticity of the fibre-array system was originally calculated from our measured elasticity of single nanowire. Comparisons of the experimental and simulative results reveal quantitative agreement except for some explainable deviations, which suggests the potential applicability of the present models and applied theories. (fast track communication)

  17. Contact Mechanics Modeling of Homogeneous and Layered Elastic-Plastic Media: Surface Roughness and Adhesion Effects

    Song, Zhichao

    2012-01-01

    The main objective of this dissertation was to analyze surface contact interaction at different length scales and to elucidate the effects of material properties (e.g., adhesion and mechanical properties), normal and shear (friction) surface tractions, and topography parameters (e.g., roughness) on contact deformation. To accomplish this objective, a surface adhesion model based on an interatomic potential was incorporated into finite element contact models of rough surfaces exhibiting multi-...

  18. Combined modeling of cell aggregation and adhesion mediated by receptor–ligand interactions under shear flow

    Yu Du

    2015-11-01

    Full Text Available Blood cell aggregation and adhesion to endothelial cells under shear flow are crucial to many biological processes such as thrombi formation, inflammatory cascade, and tumor metastasis, in which these cellular interactions are mainly mediated by the underlying receptor–ligand bindings. While theoretical modeling of aggregation dynamics and adhesion kinetics of interacting cells have been well studied separately, how to couple these two processes remains unclear. Here we develop a combined model that couples cellular aggregation dynamics and adhesion kinetics under shear flow. The impacts of shear rate (or shear stress and molecular binding affinity were elucidated. This study provides a unified model where the action of a fluid flow drives cell aggregation and adhesion under the modulations of the mechanical shear flow and receptor–ligand interaction kinetics. It offers an insight into understanding the relevant biological processes and functions.

  19. The adhesion model considering capillarity for gecko attachment system

    Kim, Tae Wan; Bhushan, Bharat

    2007-01-01

    Geckos make use of approximately a million microscale hairs (setae) that branch off into hundreds of nanoscale spatulae to cling to different smooth and rough surfaces and detach at will. This hierarchical surface construction gives the gecko the adaptability to create a large real area of contact with surfaces. It is known that van der Waals force is the primary mechanism used to adhere to surfaces, and capillary force is a secondary effect that can further increase adhesive force. To invest...

  20. Modelling and Laboratory Studies on the Adhesion Fatigue Performance for Thin-Film Asphalt and Aggregate System

    Dongsheng Wang; Junyan Yi; Decheng Feng

    2014-01-01

    Adhesion between asphalt and aggregate plays an important role in the performance of asphalt mixtures. A low-frequency adhesion fatigue test was proposed in this paper to study the effect of environment on the asphalt-aggregate adhesion system. The stress-based fatigue model had been utilized to describe the fatigue behavior of thin-film asphalt and aggregate system. The factors influencing the adhesion fatigue performance were also investigated. Experiment results show that asphalt has more ...

  1. Modeling of adhesion in tablet compression - I. atomic force microscopy and molecular simulation.

    Wang, J. J.; Li, T.; Bateman, S. D.; Erck, R.; Morris, K. R.; Energy Technology; Purdue Univ.; Novartis Pharmaceutical Corp.

    2003-04-01

    Adhesion problems during tablet manufacturing have been observed to be dependent on many formulation and process factors including the run time on the tablet press. Consequently, problems due to sticking may only become apparent towards the end of the development process when a prolonged run on the tablet press is attempted for the first time. It would be beneficial to predict in a relative sense if a formulation or new chemical entity has the potential for adhesion problems early in the development process. It was hypothesized that favorable intermolecular interaction between the drug molecules and the punch face is the first step or criterion in the adhesion process. Therefore, the rank order of adhesion during tablet compression should follow the rank order of these energies of interaction. The adhesion phenomenon was investigated using molecular simulations and contact mode atomic force microscopy (AFM). Three model compounds were chosen from a family of profen compounds. Silicon nitride AFM tips were modified by coating a 20-nm iron layer on the surfaces by sputter coating. Profen flat surfaces were made by melting and recrystallization. The modified AFM probe and each profen surface were immersed in the corresponding profen saturated water during force measurements using AFM. The work of adhesion between iron and ibuprofen, ketoprofen, and flurbiprofen in vacuum were determined to be -184.1, -2469.3, -17.3 mJ {center_dot} m-2, respectively. The rank order of the work of adhesion between iron and profen compounds decreased in the order: ketoprofen > ibuprofen > flurbiprofen. The rank order of interaction between the drug molecules and the iron superlattice as predicted by molecular simulation using Cerius2 is in agreement with the AFM measurements. It has been demonstrated that Atomic Force Microscopy is a powerful tool in studying the adhesion phenomena between organic drug compounds and metal surface. The study has provided insight into the adhesion problems

  2. Modeling keratinocyte wound healing dynamics: Cell-cell adhesion promotes sustained collective migration.

    Nardini, John T; Chapnick, Douglas A; Liu, Xuedong; Bortz, David M

    2016-07-01

    The in vitro migration of keratinocyte cell sheets displays behavioral and biochemical similarities to the in vivo wound healing response of keratinocytes in animal model systems. In both cases, ligand-dependent Epidermal Growth Factor Receptor (EGFR) activation is sufficient to elicit collective cell migration into the wound. Previous mathematical modeling studies of in vitro wound healing assays assume that physical connections between cells have a hindering effect on cell migration, but biological literature suggests a more complicated story. By combining mathematical modeling and experimental observations of collectively migrating sheets of keratinocytes, we investigate the role of cell-cell adhesion during in vitro keratinocyte wound healing assays. We develop and compare two nonlinear diffusion models of the wound healing process in which cell-cell adhesion either hinders or promotes migration. Both models can accurately fit the leading edge propagation of cell sheets during wound healing when using a time-dependent rate of cell-cell adhesion strength. The model that assumes a positive role of cell-cell adhesion on migration, however, is robust to changes in the leading edge definition and yields a qualitatively accurate density profile. Using RNAi for the critical adherens junction protein, α-catenin, we demonstrate that cell sheets with wild type cell-cell adhesion expression maintain migration into the wound longer than cell sheets with decreased cell-cell adhesion expression, which fails to exhibit collective migration. Our modeling and experimental data thus suggest that cell-cell adhesion promotes sustained migration as cells pull neighboring cells into the wound during wound healing. PMID:27105673

  3. A simple beam model to analyse the durability of adhesively bonded tile floorings in presence of shrinkage

    S. de Miranda

    2014-07-01

    Full Text Available A simple beam model for the evaluation of tile debonding due to substrate shrinkage is presented. The tile-adhesive-substrate package is modeled as an Euler-Bernoulli beam laying on a two-layer elastic foundation. An effective discrete model for inter-tile grouting is introduced with the aim of modelling workmanship defects due to partial filled groutings. The model is validated using the results of a 2D FE model. Different defect configurations and adhesive typologies are analysed, focusing the attention on the prediction of normal stresses in the adhesive layer under the assumption of Mode I failure of the adhesive.

  4. Modeling of the Peeling Process of Pressure-sensitive Adhesive Tapes with the Combination of Maxwell Elements

    Sato, Katsuhiko; Toda, Akihiko

    2004-01-01

    A simple model for the peeling process of pressure-sensitive adhesive tape is presented. The model consists of linear springs and dashpots and can be solved analytically. Based on the modeling, the curved profile of the peeling tape is spontaneously determined in terms of viscoelastic properties of adhesives. Using this model, two experimental results are discussed: critical peel rates in the peel force and the peel rate dependence of the detachment process of adhesive from the substrate.

  5. Model for Probing Membrane-Cortex Adhesion by Micropipette Aspiration and Fluctuation Spectroscopy

    Alert, Ricard; Casademunt, Jaume; Brugués, Jan; Sens, Pierre

    2015-04-01

    We propose a model for membrane-cortex adhesion which couples membrane deformations, hydrodynamics and kinetics of membrane-cortex ligands. In its simplest form, the model gives explicit predictions for the critical pressure for membrane detachment and for the value of adhesion energy. We show that these quantities exhibit a significant dependence on the active acto-myosin stresses. The model provides a simple framework to access quantitative information on cortical activity by means of micropipette experiments. We also extend the model to incorporate fluctuations and show that detailed information on the stability of membrane-cortex coupling can be obtained by a combination of micropipette aspiration and fluctuation spectroscopy measurements.

  6. Adhesion of silver nanoparticles on the clay substrates; modeling and experiment

    Adhesion of silver nanoparticles on the montmorillonite and kaolinite substrates has been investigated using molecular modeling (force field calculations) that enabled the estimation and comparison of adhesion energies for Ag/montmorillonite and Ag/kaolinite nanocomposites and revealed the preferred orientation of Ag nanoparticles on the silicate substrates. Results of the modeling have been confronted with experiment (X-ray fluorescence, high-resolution transmission electron microscopy). This confrontation has shown that the results of the modeling are consistent with the experimental data and illustrated the capability of the molecular modeling for prediction of the nanoparticles orientation, structure and stability of the nanoparticle/substrate nanocomposite.

  7. Model for probing membrane-cortex adhesion by micropipette aspiration and fluctuation spectroscopy

    Alert, Ricard; Brugués, Jan; Sens, Pierre

    2016-01-01

    We propose a model for membrane-cortex adhesion which couples membrane deformations, hydrodynamics and kinetics of membrane-cortex ligands. In its simplest form, the model gives explicit predictions for the critical pressure for membrane detachment and for the value of adhesion energy. We show that these quantities exhibit a significant dependence on the active acto-myosin stresses. The model provides a simple framework to access quantitative information on cortical activity by means of micropipette experiments. We also extend the model to incorporate fluctuations and show that detailed information on the stability of membrane-cortex coupling can be obtained by a combination of micropipette aspiration and fluctuation spectroscopy measurements.

  8. Application of Extended Tanh Method to Generalized Burgers-type Equations

    Hamid Panahipour

    2012-02-01

    Full Text Available In this paper, we show that the extended tanh method can be applied readily to generate exact soliton solutions of generalized forms of Burgers-KdV, Burgers-EW, two-dimensional Burgers-KdV and two-dimensional Burgers-EW equations.

  9. The deterministic and statistical Burgers equation

    Fournier, J.-D.; Frisch, U.

    Fourier-Lagrangian representations of the UV-region inviscid-limit solutions of the equations of Burgers (1939) are developed for deterministic and random initial conditions. The Fourier-mode amplitude behavior of the deterministic case is characterized by complex singularities with fast decrease, power-law preshocks with k indices of about -4/3, and shocks with k to the -1. In the random case, shocks are associated with a k to the -2 spectrum which overruns the smaller wavenumbers and appears immediately under Gaussian initial conditions. The use of the Hopf-Cole solution in the random case is illustrated in calculations of the law of energy decay by a modified Kida (1979) method. Graphs and diagrams of the results are provided.

  10. Dennexin peptides modeled after the homophilic binding sites of the neural cell adhesion molecule (NCAM) promote neuronal survival, modify cell adhesion and impair spatial learning

    Køhler, Lene B; Christensen, Claus; Rossetti, Clara; Fantin, Martina; Sandi, Carmen; Bock, Elisabeth; Berezin, Vladimir

    2010-01-01

    Neural cell adhesion molecule (NCAM)-mediated cell adhesion results in activation of intracellular signaling cascades that lead to cellular responses such as neurite outgrowth, neuronal survival, and modulation of synaptic activity associated with cognitive processes. The crystal structure of the...... between Ig1 and Ig3 and between Ig2 and Ig2, respectively, observed in the crystal structure. Although the two dennexin peptides differed in amino acid sequence, they both modulated cell adhesion, reflected by inhibition of NCAM-mediated neurite outgrowth. Both dennexins also promoted neuronal survival...... immunoglobulin (Ig) 1-2-3 fragment of the NCAM ectodomain has revealed novel mechanisms for NCAM homophilic adhesion. The present study addressed the biological significance of the so called dense zipper formation of NCAM. Two peptides, termed dennexinA and dennexinB, were modeled after the contact interfaces...

  11. The superposition method in seeking the solitary wave solutions to the KdV-Burgers equation

    Yuanxi Xie; Jilashi Tang

    2006-03-01

    In this paper, starting from the careful analysis on the characteristics of the Burgers equation and the KdV equation as well as the KdV-Burgers equation, the superposition method is put forward for constructing the solitary wave solutions of the KdV-Burgers equation from those of the Burgers equation and the KdV equation. The solitary wave solutions for the KdV-Burgers equation are presented successfully by means of this method.

  12. Improved model for the adhesion of μcantilevers: theory and experiments

    A nonlinear method is proposed to calculate the adhesion energy (strain energy release rate) of stiction-failed μcantilever beams with large deflections. The proposed method uses a nonlinear theory for the deflection of a beam and an energy method for calculating the beam’s strain energy. It is shown that current models used to predict μcantilevers’ profile breakdown when the beam deflection exceeds 27% of the thickness due to the onset of longitudinal stresses in the μcantilevers. Because the present model captures longitudinal stresses in the μcantilevers and consequently their contribution to the strain energy, mode I and mode II contributions to the adhesion energy can be discerned. A set of experiments are performed using the peel test scheme with poly-Si μcantilever stiction failed on a poly-Si substrate. Results processed using the present model indicate that the adhesion energy of the μcantilevers actually increases with increased height of the μcantilever’s base. This increase in the adhesion energy is attributed to the manner of loading that the μcantilevers experience which leads to increased contact area and the concomitant increase of adhesion. (paper)

  13. Numerical analysis of single particle impact in the context of Cold Spray: a new adhesion model

    Profizi, P.; Combescure, A.; Ogawa, K.

    2016-03-01

    A new adhesion model for numerical simulation of single particle impact in the context of Cold Spray is introduced. As in other studies, cohesive forces are put between the particle and substrate to account for adhesion. In this study however, the forces are put only when a local physical criterion is met. The physical phenomenon most often attributed to Cold Spray adhesion is a shear stress instability. The Johnson-Cook material law is used with a shear damage softening law to enable strong localization at the interface without the need for an extremely fine mesh. This localization is then detected as a drop in local yield stress value by the algorithm, which then implements a local cohesive force. The evolution of this cohesive force is defined by an energy dissipative cohesive model, using a surface adhesion energy as a material parameter. Each cohesive link is broken once all its associated surface energy is dissipated. A criterion on the damage value is also used to break a cohesive bond prematurely, to account for the effect of erosion at higher speeds. This model is found to reproduce the Cold Spray-like adhesion behavior with observed critical and maximum speeds.

  14. A New Material Model for 2D FE Analysis of Adhesively Bonded Composite Joints

    Libin ZHAO

    2014-12-01

    Full Text Available Effective and convenient stress analysis techniques play important roles in the analysis and design of adhesively bonded composite joints. A new material model is presented at the level of composite ply according to the orthotropic elastic mechanics theory and plane strain assumption. The model proposed has the potential to reserve nature properties of laminates with ply-to-ply modeling. The equivalent engineering constants in the model are obtained only by the material properties of unidirectional composites. Based on commercial FE software ABAQUS, a 2D FE model of a single-lap adhesively bonded joint was established conveniently by using the new model without complex modeling process and much professional knowledge. Stress distributions in adhesive were compared with the numerical results by Tsai and Morton and interlaminar stresses between adhesive and adherents were compared with the results from a detailed 3D FE analysis. Good agreements in both cases verify the validity of the proposed model. DOI: http://dx.doi.org/10.5755/j01.ms.20.4.5960

  15. A Regularization of Burgers Equation using a Filtered Convective Velocity

    Norgard, Greg

    2008-01-01

    This paper examines the properties of a regularization of Burgers equation in one and multiple dimensions using a filtered convective velocity, which we have dubbed as convectively filtered Burgers (CFB) equation. A physical motivation behind the filtering technique is presented. An existence and uniqueness theorem for multiple dimensions and a general class of filters is proven. Multiple invariants of motion are found for the CFB equation and are compared with those found in viscous and inviscid Burgers equation. Traveling wave solutions are found for a general class of filters and are shown to converge to weak solutions of inviscid Burgers equation with the correct wave speed. Accurate numerical simulations are conducted in 1D and 2D cases where the shock behavior, shock thickness, and kinetic energy decay are examined. Energy spectrum are also examined and are shown to be related to the smoothness of the solutions.

  16. Burgers' turbulence problem with linear or quadratic external potential

    Barndorff-Nielsen, Ole Eiler; Leonenko, N.N.

    2005-01-01

    We consider solutions of Burgers' equation with linear or quadratic external potential and stationary random initial conditions of Ornstein-Uhlenbeck type. We study a class of limit laws that correspond to a scale renormalization of the solutions.......We consider solutions of Burgers' equation with linear or quadratic external potential and stationary random initial conditions of Ornstein-Uhlenbeck type. We study a class of limit laws that correspond to a scale renormalization of the solutions....

  17. Enhanced Lifespan of Smooth Solutions of a Burgers-Hilbert Equation

    Hunter, John

    2011-01-01

    We consider an initial value problem for a quadratically nonlinear inviscid Burgers-Hilbert equation that models the motion of vorticity discontinuities. We use a normal form transformation, which is implemented by means of a near-identity coordinate change of the independent spatial variable, to prove the existence of small, smooth solutions over cubically nonlinear time-scales. For vorticity discontinuities, this result means that there is a cubically nonlinear time-scale before the onset of filamentation.

  18. On exact solutions for oscillatory flows in a generalized Burgers fluid with slip condition

    Hayat, Tasawar [Dept. of Mathematics, Quaid-i-Azam Univ., Islamabad (Pakistan); Dept. of Mathematics, Coll. of Sciences, KS Univ., Riyadh (Saudi Arabia); Najam, Saher [Theoretical Plasma Physics Div., PINSTECH, P.O. Nilore, Islamabad (Pakistan); Sajid, Muhammad; Mesloub, Said [Dept. of Mathematics, Coll. of Sciences, KS Univ., Riyadh (Saudi Arabia); Ayub, Muhammad [Dept. of Mathematics, Quaid-i-Azam Univ., Islamabad (Pakistan)

    2010-05-15

    An analysis is performed for the slip effects on the exact solutions of flows in a generalized Burgers fluid. The flow modelling is based upon the magnetohydrodynamic (MHD) nature of the fluid and modified Darcy law in a porous space. Two illustrative examples of oscillatory flows are considered. The results obtained are compared with several limiting cases. It has been shown here that the derived results hold for all values of frequencies including the resonant frequency. (orig.)

  19. ANALISIS KEPUASAN KONSUMEN RESTORAN CEPAT SAJI MENGGUNAKAN METODE PARTIAL LEAST SQUARE (Studi Kasus: Burger King Bali)

    MADE SANJIWANI; KETUT JAYANEGARA; I PUTU EKA N. KENCANA

    2015-01-01

    The were two aims of this research. First is to get model of the relation between the latent variable quality of service and product quality to customer satisfaction. The second was to determine the influence of service quality on customer satisfaction and the influence of product quality on consumer satisfaction at Burger King Bali. This research implemented Partial Least Square method with 3 second order variables is the service quality, product quality, and customer satisfaction. In this r...

  20. Characterization and Development of General Material Models for use in Modeling Structures Bonded with Ductile Adhesives

    Cassino, Christopher

    2005-01-01

    Structural adhesives are materials that are capable of bearing significant loads in shear, and sometimes tension, over a range of strains and strain rates. Adhesively bonded structures can dissipate large amounts of mechanical energy and can be lighter and more efficient than many bolted or vibration welded parts. The largest barrier to using structural adhesives in more applications is the many challenges engineers are presented with when designing and analyzing adhesively bonded structures....

  1. Advanced adhesives in electronics

    Bailey, C

    2011-01-01

    Adhesives are widely used in the manufacture of electronic devices to act as passive and active components. Recently there has been considerable interest in the use of conductive adhesives. This book reviews key types of conductive adhesives, processing methods, properties and the way they can be modelled as well as potential applications.$bAdhesives for electronic applications serve important functional and structural purposes in electronic components and packaging, and have developed significantly over the last few decades. Advanced adhesives in electronics reviews recent developments in adhesive joining technology, processing and properties. The book opens with an introduction to adhesive joining technology for electronics. Part one goes on to cover different types of adhesive used in electronic systems, including thermally conductive adhesives, isotropic and anisotropic conductive adhesives and underfill adhesives for flip-chip applications. Part two focuses on the properties and processing of electronic ...

  2. A New Material Model for 2D FE Analysis of Adhesively Bonded Composite Joints

    Zhao, Libin; Wang, Yana; TianLiang QIN; Zhang, Jianyu

    2014-01-01

    Effective and convenient stress analysis techniques play important roles in the analysis and design of adhesively bonded composite joints. A new material model is presented at the level of composite ply according to the orthotropic elastic mechanics theory and plane strain assumption. The model proposed has the potential to reserve nature properties of laminates with ply-to-ply modeling. The equivalent engineering constants in the model are obtained only by the material properties of unidirec...

  3. Modeling of cell adhesion and deformation mediated by receptor-ligand interactions.

    Golestaneh, Amirreza F; Nadler, Ben

    2016-04-01

    The current work is devoted to studying adhesion and deformation of biological cells mediated by receptors and ligands in order to enhance the existing models. Due to the sufficient in-plane continuity and fluidity of the phospholipid molecules, an isotropic continuum fluid membrane is proposed for modeling the cell membrane. The developed constitutive model accounts for the influence of the presence of receptors on the deformation and adhesion of the cell membrane through the introduction of spontaneous area dilation. Motivated by physics, a nonlinear receptor-ligand binding force is introduced based on charge-induced dipole interaction. Diffusion of the receptors on the membrane is governed by the receptor-ligand interaction via Fick's Law and receptor-ligand interaction. The developed model is then applied to study the deformation and adhesion of a biological cell. The proposed model is used to study the role of the material, binding, spontaneous area dilation and environmental properties on the deformation and adhesion of the cell. PMID:26093646

  4. SPH modeling of adhesion in fast dynamics: Application to the Cold Spray process

    Profizi, Paul; Combescure, Alain; Ogawa, Kahuziro

    2016-04-01

    The objective of this paper is to show, in a specific case, the importance of modeling adhesive forces when simulating the bouncing of very small particles impacting a substrate at high speed. The implementation of this model into a fast-dynamics SPH code is described. Taking the example of an impacted elastic cylinder, we show that the adhesive forces, which are surface forces, play a significant role only if the particles are sufficiently small. The effect of the choice of the type of interaction law in the cohesive zone is studied and some conclusions on the relevance of the modeling of the adhesive forces for fast-dynamics impacts are drawn. Then, the adhesion model is used to simulate the Cold Spray process. An aluminum particle is projected against a substrate made of the same material at a velocity ranging from 200 to 1000 m ṡs-1. We study the effects of the various modeling assumptions on the final result: bouncing or sticking. Increasingly complex models are considered. At a 200 m ṡs-1 impact velocity, elastic behavior is assumed, the substrate being simply supported at its base and supplied with absorbing boundaries. The same absorbing boundaries are also used for all the other simulations. Then, plasticity is introduced and the impact velocity is increased up to 1000 m ṡs-1. At the highest velocities, the resulting strains are very significant. The calculations show that if the adhesion model is appropriately chosen, it is possible to reproduce the experimental observations: the particles stick to the substrate in a range of impact velocities surrounded by two velocity ranges in which the particles bounce.

  5. Localized Modeling of Biochemical and Flow Interactions during Cancer Cell Adhesion.

    Julie Behr

    Full Text Available This work focuses on one component of a larger research effort to develop a simulation tool to model populations of flowing cells. Specifically, in this study a local model of the biochemical interactions between circulating melanoma tumor cells (TC and substrate adherent polymorphonuclear neutrophils (PMN is developed. This model provides realistic three-dimensional distributions of bond formation and attendant attraction and repulsion forces that are consistent with the time dependent Computational Fluid Dynamics (CFD framework of the full system model which accounts local pressure, shear and repulsion forces. The resulting full dynamics model enables exploration of TC adhesion to adherent PMNs, which is a known participating mechanism in melanoma cell metastasis. The model defines the adhesion molecules present on the TC and PMN cell surfaces, and calculates their interactions as the melanoma cell flows past the PMN. Biochemical rates of reactions between individual molecules are determined based on their local properties. The melanoma cell in the model expresses ICAM-1 molecules on its surface, and the PMN expresses the β-2 integrins LFA-1 and Mac-1. In this work the PMN is fixed to the substrate and is assumed fully rigid and of a prescribed shear-rate dependent shape obtained from micro-PIV experiments. The melanoma cell is transported with full six-degrees-of-freedom dynamics. Adhesion models, which represent the ability of molecules to bond and adhere the cells to each other, and repulsion models, which represent the various physical mechanisms of cellular repulsion, are incorporated with the CFD solver. All models are general enough to allow for future extensions, including arbitrary adhesion molecule types, and the ability to redefine the values of parameters to represent various cell types. The model presented in this study will be part of a clinical tool for development of personalized medical treatment programs.

  6. Systemic EP4 Inhibition Increases Adhesion Formation in a Murine Model of Flexor Tendon Repair.

    Geary, Michael B; Orner, Caitlin A; Bawany, Fatima; Awad, Hani A; Hammert, Warren C; O'Keefe, Regis J; Loiselle, Alayna E

    2015-01-01

    Flexor tendon injuries are a common clinical problem, and repairs are frequently complicated by post-operative adhesions forming between the tendon and surrounding soft tissue. Prostaglandin E2 and the EP4 receptor have been implicated in this process following tendon injury; thus, we hypothesized that inhibiting EP4 after tendon injury would attenuate adhesion formation. A model of flexor tendon laceration and repair was utilized in C57BL/6J female mice to evaluate the effects of EP4 inhibition on adhesion formation and matrix deposition during flexor tendon repair. Systemic EP4 antagonist or vehicle control was given by intraperitoneal injection during the late proliferative phase of healing, and outcomes were analyzed for range of motion, biomechanics, histology, and genetic changes. Repairs treated with an EP4 antagonist demonstrated significant decreases in range of motion with increased resistance to gliding within the first three weeks after injury, suggesting greater adhesion formation. Histologic analysis of the repair site revealed a more robust granulation zone in the EP4 antagonist treated repairs, with early polarization for type III collagen by picrosirius red staining, findings consistent with functional outcomes. RT-PCR analysis demonstrated accelerated peaks in F4/80 and type III collagen (Col3a1) expression in the antagonist group, along with decreases in type I collagen (Col1a1). Mmp9 expression was significantly increased after discontinuing the antagonist, consistent with its role in mediating adhesion formation. Mmp2, which contributes to repair site remodeling, increases steadily between 10 and 28 days post-repair in the EP4 antagonist group, consistent with the increased matrix and granulation zones requiring remodeling in these repairs. These findings suggest that systemic EP4 antagonism leads to increased adhesion formation and matrix deposition during flexor tendon healing. Counter to our hypothesis that EP4 antagonism would improve the

  7. Antioxidant Small-spotted Catshark Burgers

    Joana Patriarca

    2014-06-01

    Full Text Available Tons of fish are rejected daily, not only on board, but also on shore during the industrial processing (INE, 2012. In order to reuse these wastes, restructured seafood products must be developed. On the other hand, in western countries a trend in the increase of the number of cancer cases is observed, especially among the youngsters (Steliarova-Foucher et al, 2004. A healthy and high quality nutrition plays an important role on cancer prevention (Davis et al, 2010; Kuno et al, 2012. Many authors found several phytochemical compounds naturally present in foods with powerful antioxidant properties. These have the ability to stop or delay the development of the tumors, by inducing apoptosis and prevent angiogenesis or metastasis (Kou et al, 2013. In the present work, it was developed a restructured functional food based on rejected small-spotted catshark. The functional capacity of this food is attained by the addition of ingredients with proven antioxidant ability. Studies have been made to optimize the antioxidant extraction process from the fish burger through different combinations of solvent extraction. Furthermore, the antioxidant activity of the restructured product was characterized in terms of total phenolic content (TPC, 2,2-diphenyl-1-picrylhydrazyl (DPPH radical scavenging activity and oxygen radical absorbance capacity (ORAC. Apparently, a higher level of antioxidants is detected when methanol is used for extraction during twelve hours at room temperature. The results also showed the functional fish product presents a higher capacity for DPPH reduction and increased values for ORAC by comparison with small-spotted catshark only.

  8. From flexibility to cooperativity: multiscale modeling of cadherin-mediated cell adhesion

    Wu, Yinghao

    2013-03-01

    Cadherins constitute a large family of Ca2 +-dependent adhesion molecules in the Inter-cellular junctions that play a pivotal role in the assembly of cells into specific three-dimensional tissues. Although the molecular mechanisms underlying cadherin-mediated cell adhesion are still not fully understood, it seems likely that both cis dimers that are formed by binding of extracellular domains of two cadherins on the same cell surface, and trans-dimers formed between cadherins on opposing cell surfaces, are critical to trigger the junction formation. Here we present a new multiscale computational strategy to model the process of junction formation based on the knowledge of cadherin molecular structures and its 3D binding affinities. The cell interfacial region is defined by a simplified system where each of two interacting membrane surfaces is represented as a two-dimensional lattice with each cadherin molecule treated as a randomly diffusing unit. The binding energy for a pair of interacting cadherins in this two-dimensional discrete system is obtained from 3D binding affinities through a renormalization process derived from statistical thermodynamics. The properties of individual cadherins used in the lattice model are based on molecular level simulations. Our results show that within the range of experimentally-measured binding affinities, cadherins condense into junctions driven by the coupling of cis and trans interactions. The key factor appears to be a loss of molecular flexibility during trans dimerization that increases the magnitude of lateral cis interactions. We have also developed stochastic dynamics to study the adhesion of multiple cells. Each cell in the system is described as a mechanical entity and adhesive properties between two cells are derived from the lattice model. The cellular simulations are used to study the specific problems of tissue morphogenesis and tumor metastasis. The consequent question and upcoming challenge is to understand the

  9. On the Maximum Enstrophy Growth in Burgers Equation

    The regularity of solutions of the three-dimensional Navier-Stokes equation is controlled by the boundedness of the enstrophy ε. The best estimate available to-date for its rate of growth is dε/dt ≤ Cε3, where C > 0, which was recently found to be sharp by Lu and Doering (2008). Applying straightforward time-integration to this instantaneous estimate leads to the possibility of loss of regularity in finite time, the so-called blow-up, and therefore the central question is to establish sharpness of such finite-time bounds. We consider an analogous problem for Burgers equation which is used as a toy model. The problem of saturation of finite-time estimates for the enstrophy growth is stated as a PDE-constrained optimization problem, where the control variable φ represents the initial condition, which is solved numerically for a wide range of time windows T > 0 and initial enstrophies ε0. We find that the maximum enstrophy growth in finite time scales as ε0α with α ≈ 3/2. The exponent is smaller than α = 3 predicted by analytic means, therefore suggesting lack of sharpness of analytical estimates.

  10. Non-linear vorticity upsurge in Burgers flow

    Lam, F

    2016-01-01

    We demonstrate that numerical solutions of Burgers' equation can be obtained by a scale-totality algorithm for fluids of small viscosity (down to one billionth). Two sets of initial data, modelling simple shears and wall boundary layers, are chosen for our computations. Most of the solutions are carried out well into the fully turbulent regime over finely-resolved scales in space and in time. It is found that an abrupt spatio-temporal concentration in shear constitutes an essential part during the flow evolution. The vorticity surge has been instigated by the non-linearity complying with instantaneous enstrophy production while ad hoc disturbances play no role in the process. In particular, the present method predicts the precipitous vorticity re-distribution and accumulation, predominantly over localised regions of minute dimension. The growth rate depends on viscosity and is a strong function of initial data. Nevertheless, the long-time energy decay is history-independent and is inversely proportional to ti...

  11. IgG Adhesion on Hydrophobic Surfaces: Theory, Modelling, and Application to ELISA

    de Thier, P

    2016-01-01

    Enzyme-Linked ImmunoSorbent Assays (ELISA) are a range of widely used analytical methods whose implementation requires to build antibodies (IgG) thin films onto surfaces predominantly made of polystyrene. The high hydrophobicity of polystyrene ensures a spontaneous and strong adhesion of proteins allowing to easily build IgG monolayers. Since the ELISA improvements definitely lie in the comprehension of physico-chemical mechanisms on which IgG immobilization on hydrophobic surfaces are relied, this work develops a theorization essay (thermodynamics of the so-called hydrophobic effect and of thin films building) emphasized by numerical modelling (random sequential additions model, i.e. RSA) and experimental estimations by atomic force microscopy (AFM) and ELISA. Keeping in mind the hydrophobic effect, thermodynamics (of irreversible processes) allows to explain why IgG adhesion on polystyrene occurs whereas numerical modelling approaches show a way of surface saturation leading to promote IgG orientations expe...

  12. Modelling and Laboratory Studies on the Adhesion Fatigue Performance for Thin-Film Asphalt and Aggregate System

    Dongsheng Wang

    2014-01-01

    Full Text Available Adhesion between asphalt and aggregate plays an important role in the performance of asphalt mixtures. A low-frequency adhesion fatigue test was proposed in this paper to study the effect of environment on the asphalt-aggregate adhesion system. The stress-based fatigue model had been utilized to describe the fatigue behavior of thin-film asphalt and aggregate system. The factors influencing the adhesion fatigue performance were also investigated. Experiment results show that asphalt has more important effect on the adhesion performance comparing with aggregate. Basalt, which is regarded as hydrophobic aggregates with low silica content, has better adhesion performance to asphalt binder when compared with granite. The effects of aging on the adhesion fatigue performance are different for PG64-22 and rubber asphalt. Long-term aging is found to reduce the adhesion fatigue lives for rubber asphalt and aggregate system, while the effect of long-term aging for aggregate and PG64-22 binder system is positive. Generally the increased stress amplitude and test temperature could induce greater damage and lead to less fatigue lives for adhesion test system.

  13. Modelling and laboratory studies on the adhesion fatigue performance for thin-film asphalt and aggregate system.

    Wang, Dongsheng; Yi, Junyan; Feng, Decheng

    2014-01-01

    Adhesion between asphalt and aggregate plays an important role in the performance of asphalt mixtures. A low-frequency adhesion fatigue test was proposed in this paper to study the effect of environment on the asphalt-aggregate adhesion system. The stress-based fatigue model had been utilized to describe the fatigue behavior of thin-film asphalt and aggregate system. The factors influencing the adhesion fatigue performance were also investigated. Experiment results show that asphalt has more important effect on the adhesion performance comparing with aggregate. Basalt, which is regarded as hydrophobic aggregates with low silica content, has better adhesion performance to asphalt binder when compared with granite. The effects of aging on the adhesion fatigue performance are different for PG64-22 and rubber asphalt. Long-term aging is found to reduce the adhesion fatigue lives for rubber asphalt and aggregate system, while the effect of long-term aging for aggregate and PG64-22 binder system is positive. Generally the increased stress amplitude and test temperature could induce greater damage and lead to less fatigue lives for adhesion test system. PMID:25054187

  14. A Granule Model for Evaluating Adhesion of Pharmaceutical Binders

    Hossein Orafai

    2003-01-01

    Granule capability is defined in terms of the strength of individual granule and friability of granulation batch to withstand breaking, abrasion and compactibility. Binder(s) are added to perform the above properties .The common methods to asses their capability are to test crushing strength of the granules directly and to make statistical analysis and /or testing the friability of bulk granulation. In this work four substrate models including polymethylmetacrylate beads(PMMA),glass powder, a...

  15. Painlevé Analysis and Some Solutions of(2+1)-Dimensional Generalized Burgers Equations

    HONG Ke-Zhu; WU B-in; CHEN Xian-Feng

    2003-01-01

    Burgers equation ut = 2uux + uxx describes a lot of phenomena in physics fields, and it has attracted much attention.In this paper,the Burgers equation is generalized to (2+1) dimensions.By means of the Painlev(e') analysis,the most generalized Painlev(e') integrable(2+1)-dimensional integrable Burgers systems are obtained.Some exact solutions of the generalized Burgers system are obtained via variable separation approach.

  16. A Granule Model for Evaluating Adhesion of Pharmaceutical Binders

    Hossein Orafai

    2003-10-01

    Full Text Available Granule capability is defined in terms of the strength of individual granule and friability of granulation batch to withstand breaking, abrasion and compactibility. Binder(s are added to perform the above properties .The common methods to asses their capability are to test crushing strength of the granules directly and to make statistical analysis and /or testing the friability of bulk granulation. In this work four substrate models including polymethylmetacrylate beads(PMMA,glass powder, acetaminophen, and para-aminobebzoic acid were chosen. The binder models were corn starch, gelatin, methylcellulose (MC and hydroxypropylmethylcellulose (HPMC. After massing the substrates with the binder solutions, discs were produced by the mean of the mold technique. The discs were dried and conditioned and then tested for tensile strength while the failed areas were scanned by SEM. Various granulations were made and the results of friability and crush strength were compared with the discs strength .The bond areas in the SEM showed the trend with the binder concentration .A comparison of the standard deviation shows that discs have much lower level of the strength than granules. The resulting discs showed a higher performance which is related to the stems for the discs shape .In conclusion, this method is a simple and is applicable to differentiate efficacy of binder under studies.

  17. Optimal fixed-finite-dimensional compensator for Burgers' equation with unbounded input/output operators

    Burns, John A.; Marrekchi, Hamadi

    1993-01-01

    The problem of using reduced order dynamic compensators to control a class of nonlinear parabolic distributed parameter systems was considered. Concentration was on a system with unbounded input and output operators governed by Burgers' equation. A linearized model was used to compute low-order-finite-dimensional control laws by minimizing certain energy functionals. Then these laws were applied to the nonlinear model. Standard approaches to this problem employ model/controller reduction techniques in conjunction with linear quadratic Gaussian (LQG) theory. The approach used is based on the finite dimensional Bernstein/Hyland optimal projection theory which yields a fixed-finite-order controller.

  18. A CLASS OF ALTERNATING GROUP METHOD OF BURGERS' EQUATION

    王文洽

    2004-01-01

    Some new Saul' yev type asymmetric difference schemes for Burgers' equation is given, by the use of the schemes, a kind of alternating group four points method for solving nonlinear Burgers' equation is constructed here. The basic idea of the method is that the grid points on the same time level is divided into a number of groups, the difference equations of each group can be solved independently, hence the method with intrinsic parallelism can be used directly on parallel computer. The method is unconditionally stable by analysis of linearization procedure. The numerical experiments show that the method has good stability and accuracy.

  19. Nanobioprobe for the Determination of Pork Adulteration in Burger Formulations

    Ali, M. E.; MUSTAFA, S.; Hashim, U.; Che Man, Y. B.; K L Foo

    2012-01-01

    We report the development of a swine-specific hybrid nanobioprobe through a covalent integration of a fluorophore-labeled 27-nucleotide AluI-fragment of swine cytochrome b gene to a 3 nm gold nanoparticle for the determination of pork adulteration in processed meat products. We tested the probe to estimate adulterated pork in ready-to-eat pork-spiked beef burgers. The probe quantitatively detected 1–100% spiked pork in burger formulations with ≥90% accuracy. A plot of observed fluorescence ag...

  20. On the Stochastic Burgers Equation and the Axiom of Choice

    Noble, John M

    2010-01-01

    The equivalence of the Choice Axiom and Tychonov compactness was proved by Kelley in 1950. Tychonov compactness is required to prove existence of the minimiser of an action functional under standard hypotheses. Solutions to the inviscid Burgers equation may be constructed by considering the minimising trajectories of associated action functionals. This construction has been used in the literature to construct an invariant measure for the stochastic inviscid Burgers equation. This article compares results that may be obtained with and without using this representation and draws conclusions about the Choice Axiom.

  1. Analyzing the dynamics of the forced Burgers equation

    Nejib Smaoui

    2000-01-01

    Full Text Available We study numerically the long-time dynamics of a system of reaction-diffusion equations that arise from the viscous forced Burgers equation (ut+uux−vuxx=F. A nonlinear transformation introduced by Kwak is used to embed the scalar Burgers equation into a system of reaction diffusion equations. The Kwak transformation is used to determine the existence of an inertial manifold for the 2-D Navier-Stokes equation. We show analytically as well as numerically that the two systems have a similar, long-time dynamical, behavior for large viscosity v.

  2. CONVERGENCE OF ADOMIAN METHOD FOR SOLVING KDV– BURGER EQUATION

    M. S. El-Azab

    2012-05-01

    Full Text Available In this paper, convergence of Adomian decomposition method (ADM when applied to KdV–Burgers equation is proved. Two approaches for extracting the soliton solutions to the nonlinear dispersive and dissipative KdV– Burgers equation are implemented. The first one is the classical ADM while, the second is the modified ADM which is called the general iteration method. Test examples are given and a comparison between the two approaches is carried out to illustrate the pertinent feature of the general iteration method.

  3. B-spline collocation methods for numerical solutions of the Burgers' equation

    İdris Dağ; Dursun Irk; Ali Şahin

    2005-01-01

    Both time- and space-splitted Burgers' equations are solved numerically. Cubic B-spline collocation method is applied to the time-splitted Burgers' equation. Quadratic B-spline collocation method is used to get numerical solution of the space-splitted Burgers' equation. The results of both schemes are compared for some test problems.

  4. Mixed-Mode Cohesive Damage Model Applied to the Simulation of the Mechanical Behaviour of Laminated Composite Adhesive Joints

    de Moura, MFSF; Campilho, RDSG; Goncalves, JPM

    2009-01-01

    A study of the mechanical behaviour of laminated composite adhesive joints is presented in this paper. The study consists of both numerical simulations and experimental tests. It concentrates on single lap-shear joints made of carbon-epoxy laminated composites and an epoxy adhesive. The main objective is to verify the adequacy of cohesive damage models for the strength prediction of bonded joints. These models are attractive in modelling fracture problems since they do not require the definit...

  5. Transchromosomic cell model of Down syndrome shows aberrant migration, adhesion and proteome response to extracellular matrix

    Cotter Finbarr E

    2009-08-01

    Full Text Available Abstract Background Down syndrome (DS, caused by trisomy of human chromosome 21 (HSA21, is the most common genetic birth defect. Congenital heart defects (CHD are seen in 40% of DS children, and >50% of all atrioventricular canal defects in infancy are caused by trisomy 21, but the causative genes remain unknown. Results Here we show that aberrant adhesion and proliferation of DS cells can be reproduced using a transchromosomic model of DS (mouse fibroblasts bearing supernumerary HSA21. We also demonstrate a deacrease of cell migration in transchromosomic cells independently of their adhesion properties. We show that cell-autonomous proteome response to the presence of Collagen VI in extracellular matrix is strongly affected by trisomy 21. Conclusion This set of experiments establishes a new model system for genetic dissection of the specific HSA21 gene-overdose contributions to aberrant cell migration, adhesion, proliferation and specific proteome response to collagen VI, cellular phenotypes linked to the pathogenesis of CHD.

  6. The Inviscid Burgers Equation with Brownian Initial Velocity

    Bertoin, Jean

    The law of the (Hopf-Cole) solution of the inviscid Burgers equation with Brownian initial velocity is made explicit. As examples of applications, we investigate the smoothness of the solution, the statistical distribution of the shocks, we determine the exact Hausdorff function of the Lagrangian regular points and investigate the existence of Lagrangian regular points in a fixed Borel set.

  7. Velocity and velocity-difference distributions in Burgers turbulence

    Boldyrev, S.; Linde, T.; Polyakov, A.

    2003-01-01

    We consider the one-dimensional Burgers equation randomly stirred at large scales by a Gaussian short-time correlated force. Using the method of dissipative anomalies, we obtain velocity and velocity-difference probability density functions and confirm the results with high-resolution numerical simulations.

  8. On a stochastic Burgers equation with Dirichlet boundary conditions

    Ekaterina T. Kolkovska

    2003-01-01

    Full Text Available We consider the one-dimensional Burgers equation perturbed by a white noise term with Dirichlet boundary conditions and a non-Lipschitz coefficient. We obtain existence of a weak solution proving tightness for a sequence of polygonal approximations for the equation and solving a martingale problem for the weak limit.

  9. On Nash equilibria for noncooperative games governed by Burgers equation

    Roubíček, Tomáš

    2007-01-01

    Roč. 132, č. 1 (2007), s. 41-50. ISSN 0022-3239 Grant ostatní: GA ČR(CZ) GA201/03/0934 Institutional research plan: CEZ:AV0Z10750506 Keywords : Nash equilibria * noncooperative games * Burgers equation Subject RIV: BA - General Mathematics Impact factor: 0.688, year: 2007

  10. Sensory profile of beef burger with reduced sodium content

    Camila Barbosa Carvalho

    2015-05-01

    Full Text Available This study determined the sensory profile of three beef burger samples, namely, CON (control, F25 (25% sodium reduction and F50 (50% sodium reduction, based on the Quantitative Descriptive Analysis (QDA. The samples´ microbial, physical and chemical composition was evaluated. Twelve panelists were selected and trained using as criteria the panelists´ discrimination power, reproducibility and consensus. Eleven terms were generated by the method of network descriptors. The intensity of each descriptor in each sample was evaluated by unstructured scale of 9 cm. Data were analyzed by ANOVA, Duncan´s mean test and principal component analysis. The sensory profile shows that low sodium beef burgers had lower fat and salty flavor when compared to untreated control and greater flavor and spice aroma. The above proves that reducing sodium intake causes increased perception burger tasters when compared to the presence of spices in the product. Treatment with 50% sodium reduction obtained the best results for texture softness and appearance. There was no significant difference (p < 0.05 in the chemical composition of ash, protein and fat in all burgers. In the case of general sensory attributes, treatments with sodium reduction obtained higher intensities of the attributes evaluated, except for meat and salt flavors.

  11. Composites containing albumin protein or cyanoacrylate adhesives and biodegradable scaffolds: I. Acute wound closure study in a rat model

    Hoffman, Grant T.; Soller, Eric C.; Heintzelman, Douglas L.; Duffy, Mark T.; Bloom, Jeffrey N.; Gilmour, Travis M.; Gonnerman, Krista N.; McNally-Heintzelman, Karen M.

    2004-07-01

    Composite adhesives composed of biodegradable scaffolds impregnated with a biological or synthetic adhesive were investigated for use in wound closure as an alternative to using either one of the adhesives alone. Two different scaffold materials were investigated: (i) a synthetic biodegradable material fabricated from poly(L-lactic-co-glycolic acid); and (ii) a biological material, small intestinal sub mucosa, manufactured by Cook BioTech. The biological adhesive was composed of 50%(w/v) bovine serum albumin solder and 0.5mg/ml indocyanine green dye mixed in deionized water, and activated with an 808-nm diode laser. The synthetic adhesive was Ethicon's Dermabond, a 2-octyl-cyanoacrylate. The tensile strength of skin incisions repaired ex vivo in a rat model, by adhesive alone or in combination with a scaffold, as well as the time-to-failure, were measured and compared. The tensile strength of repairs formed using the scaffold-enhanced biological adhesives were on average, 80% stronger than their non-enhanced counterparts, with an accompanying increase in the time-to-failure of the repairs. These results support the theory that a scaffold material with an irregular surface that bridges the wound provides a stronger, more durable and consistent adhesion, due to the distribution of the tensile stress forces over the many micro-adhesions provided by the irregular surface, rather than the one large continuous adhesive contact. This theory is also supported by several previous ex vivo experiments demonstrating enhanced tensile strength of irregular versus smooth scaffold surfaces in identical tissue repairs performed on bovine thoracic aorta, liver, spleen, small intestine and lung tissue.

  12. Peristaltic transport of a fractional Burgers' fluid with variable viscosity through an inclined tube

    Rachid, Hassan

    2015-12-01

    In the present study,we investigate the unsteady peristaltic transport of a viscoelastic fluid with fractional Burgers' model in an inclined tube. We suppose that the viscosity is variable in the radial direction. This analysis has been carried out under low Reynolds number and long-wavelength approximations. An analytical solution to the problem is obtained using a fractional calculus approach. Figures are plotted to show the effects of angle of inclination, Reynolds number, Froude number, material constants, fractional parameters, parameter of viscosity and amplitude ratio on the pressure gradient, pressure rise, friction force, axial velocity and on the mechanical efficiency.

  13. Application of the Homotopy Analysis Method for Solving the Variable Coefficient KdV-Burgers Equation

    Dianchen Lu

    2014-01-01

    Full Text Available The homotopy analysis method is applied to solve the variable coefficient KdV-Burgers equation. With the aid of generalized elliptic method and Fourier’s transform method, the approximate solutions of double periodic form are obtained. These solutions may be degenerated into the approximate solutions of hyperbolic function form and the approximate solutions of trigonometric function form in the limit cases. The results indicate that this method is efficient for the nonlinear models with the dissipative terms and variable coefficients.

  14. Painlevé property, symmetries and symmetry reductions of the coupled Burgers system

    Lian, Zeng-Ju; Chen, Li-Li; Lou, Sen-Yue

    2005-08-01

    The Painlevé property, inverse recursion operator, infinite number of symmetries and Lie symmetry reductions of the coupled Burgers equation are given explicitly. Three sets of infinitely many symmetries of the considered model are obtained by acting the recursion operator and the inverse recursion operator on the trivial symmetries such as the identity transformation, the space translation and the scaling transformation respectively. These symmetries constitute an infinite dimensional Lie algebra while its finite dimensional Lie point symmetry subalgebra is used to find possible symmetry reductions and then the group invariant solutions.

  15. A class of blowup and global analytical solutions of the viscoelastic Burgers' equations

    An, Hongli, E-mail: hongli.an@connect.polyu.hk [College of Science, Nanjing Agricultural University, Nanjing 210095 (China); Cheung, Ka-Luen, E-mail: kaluen@ied.edu.hk [Department of Mathematics and Information Technology, The Hong Kong Institute of Education, 10 Po Ling Road, Tai Po, New Territories (Hong Kong); Yuen, Manwai, E-mail: nevetsyuen@hotmail.com [Department of Mathematics and Information Technology, The Hong Kong Institute of Education, 10 Po Ling Road, Tai Po, New Territories (Hong Kong)

    2013-11-08

    In this Letter, by employing the perturbational method, we obtain a class of analytical self-similar solutions of the viscoelastic Burgers' equations. These solutions are of polynomial-type whose forms, remarkably, coincide with that given by Yuen for the other physical models, such as the compressible Euler or Navier–Stokes equations and two-component Camassa–Holm equations. Furthermore, we classify the initial conditions into several groups and then discuss the properties on blowup and global existence of the corresponding solutions, which may be readily seen from the phase diagram.

  16. A 3D ductile constitutive mixed-mode model of cohesive elements for the finite element analysis of adhesive joints

    Anyfantis, Konstantinos; Tsouvalis, Nicholas G.

    2013-01-01

    adhesive joint configurations. The specimens have been tested under uni-axial quasi-static load and the respective force and displacement loading history have been recorded. Corresponding numerical and experimental results have been compared for each joint case, respectively. Additionally, the developed...... criterion and damage propagation with the linear energetic fracture criterion. For verification and validation purposes of the proposed laws and mixed-mode model, steel adherends have been adhesively bonded with a structural ductile adhesive material in order to fabricate a series of single and double strap...

  17. Models for ultrasonic characterization of environmental degradation of interfaces in adhesive joints

    In this paper we discuss two models of environmental degradation of adhesive joints developed from experimental observation of the joint failure mode. It is found that after severe degradation, failure is dominated by the interfacial mode, i.e., by failure at the interface between adhesive and adherend. The fraction of failure in the interfacial mode was found to be related to the joint strength and to be proportional to the frequency shift of a minimum in the spectrum of the reflected ultrasonic signal. One model considers an interface as an interphase in the form of a nonhomogeneous layer composed of two phases: ''soft'' which is viscoelastic (degraded part of the interphase) and ''stiff'' corresponding to the nondamaged interphase. Increase of the ''soft'' phase fraction corresponds to the process of degradation in the interphase. The second model describes degradation in a form of disbonds filled by absorbed water at the interface. The disbonded interface is modeled by transverse spring boundary conditions, with the complex spring stiffness representing the quality of the bond. The influence of different disbond growth scenarios is considered. Advantages and drawbacks of these models are discussed

  18. Auto-cross-linked hyaluronic acid gel does not reduce intra-abdominal adhesions or abscess formation in a rat model of peritonitis.

    Sikkink, C.J.J.M.; Man, B.M. de; Bleichrodt, R.P.; Goor, H. van

    2006-01-01

    BACKGROUND: Prevention of adhesion and abscess formation would decrease mortality and morbidity after peritonitis. In this study the effect of a new anti-adhesive, auto-cross-linked hyaluronic acid polysaccharide (ACP) gel, on adhesion and abscess formation was studied in a rat peritonitis model. MA

  19. The Effect of Phospholipids (Surfactant on Adhesion and Biomechanical Properties of Tendon: A Rat Achilles Tendon Repair Model

    T. Kursat Dabak

    2015-01-01

    Full Text Available Adhesion of the tendon is a major challenge for the orthopedic surgeon during tendon repair. Manipulation of biological environment is one of the concepts to prevent adhesion. Lots of biochemicals have been studied for this purpose. We aimed to determine the effect of phospholipids on adhesion and biomechanical properties of tendon in an animal tendon repair model. Seventy-two Wistar rats were divided into 4 groups. Achilles tendons of rats were cut and repaired. Phospholipids were applied at two different dosages. Tendon adhesion was determined histopathologically and biomechanical test was performed. At macroscopic evaluation of adhesion, there are statistically significant differences between multiple-dose phospholipid injection group and Control group and also hyaluronic acid group and Control group (p0.008. Ultimate strength was highest at hyaluronic acid injection group and lowest at multiple-dose phospholipid injection group. Single-dose phospholipids (surfactant application may have a beneficial effect on the tendon adhesion. Although multiple applications of phospholipids seem the most effective regime to reduce the tendon adhesion among groups, it deteriorated the biomechanical properties of tendon.

  20. Wood adhesion cell segmentation scheme based on GVF-Snake model

    Zhao, Lei; Ma, Yan

    2010-08-01

    In order to extract the characteristic parameters of the wood cells accurately, this paper presents an efficient scheme for wood cell segmentation. This scheme is mainly based on GVF-Snake model and the method of image thinning. Firstly, computing the Category Roundness of every connectivity domain is done in order to get the degree of adhesion. Secondly, image thinning helps to get the skeleton of the cell. Finally, according to the location coordinates of skeleton and contour, it can determine the location of segmentation. Experimental results demonstrate the scheme for precise extraction with limited human intervention; it can also determine the correct edge of segmentation. Comparatively speaking, the inaccuracy is rather limited.

  1. Abdominal Adhesions

    ... adhesions? Abdominal adhesions can cause intestinal obstruction and female infertility—the inability to become pregnant after a year of trying. Abdominal adhesions can lead to female infertility by preventing fertilized eggs from reaching the uterus, ...

  2. Myxococcus xanthus gliding motors are elastically coupled to the substrate as predicted by the focal adhesion model of gliding motility

    Balagam, Rajesh; Czerwinski, Fabian; Sun, Mingzhai; Kaplan, Heidi B; Shaevitz, Joshua W; Igoshin, Oleg A

    2014-01-01

    Myxococcus xanthus is a model organism for studying bacterial social behaviors due to its ability to form complex multi-cellular structures. Knowledge of M. xanthus surface gliding motility and the mechanisms that coordinate it are critically important to our understanding of collective cell behaviors. Although the mechanism of gliding motility is still under investigation, recent experiments suggest that there are two possible mechanisms underlying force production for cell motility: the focal adhesion mechanism and the helical rotor mechanism which differ in the biophysics of the cell-substrate interactions. Whereas the focal adhesion model predicts an elastic coupling, the helical rotor model predicts a viscous coupling. Using a combination of computational modeling, imaging, and force microscopy, we find evidence for elastic coupling in support of the focal adhesion model. Using a biophysical model of the M. xanthus cell, we investigated how the mechanical interactions between cells are affected by intera...

  3. Large deformation analysis of adhesive by Eulerian method with new material model

    The material model to describe large deformation of a pressure sensitive adhesive (PSA) is presented. A relationship between stress and strain of PSA includes viscoelasticity and rubber-elasticity. Therefore, we propose the material model for describing viscoelasticity and rubber-elasticity, and extend the presented material model to the rate form for three dimensional finite element analysis. After proposing the material model for PSA, we formulate the Eulerian method to simulate large deformation behavior. In the Eulerian calculation, the Piecewise Linear Interface Calculation (PLIC) method for capturing material surface is employed. By using PLIC method, we can impose dynamic and kinematic boundary conditions on captured material surface. The representative two computational examples are calculated to check validity of the present methods.

  4. Theoretical model for adhesive friction between elastomers and rough solid surfaces

    Momozono, Satoshi; Nakamura, Kenya; Kyogoku, Keiji

    2010-03-01

    A theoretical model for the adhesive friction between elastomers and rough solid surfaces is proposed on the basis of opening crack propagation processes at the boundary of the contact interfaces and the rate processes of formation of molecular bonds on the solid surface. This model, which is expressed as a product of the terms related to the two abovementioned processes, requires some measurable and fitted parameters such as the frictional shear strength expressed as a function of viscoelastic dissipation, rate-dependent elasticity, density of bonded molecular chains at a contact junction, critical velocity related to viscoelastic relaxation, and critical velocity related to the rate process of formation of molecular bonds on the solid surface. The friction-velocity relationship exhibits a remarkable fit to previously obtained experimental results for polymers such as engineering rubber, gels, and plastics (glassy polymers), and all fitting parameters are physically reasonable. The viscoelastic index "n" is also related to the "glass-to-rubber transition" of a nanometer-thick polymer layer for frictional behavior. Thus, from a practical viewpoint, this model can be used effectively for fitting the adhesive friction behavior of polymers.

  5. Sailing the Deep Blue Sea of Decaying Burgers Turbulence

    Bauer, M; Bauer, Michel; Bernard, Denis

    1999-01-01

    We study Lagrangian trajectories and scalar transport statistics in decaying Burgers turbulence. We choose velocity fields, solutions of the inviscid Burgers equation, whose probability distributions are specified by Kida's statistics. They are time-correlated, not time-reversal invariant and not Gaussian. We discuss in some details the effect of shocks on trajectories and transport equations. We derive the inviscid limit of these equations using a formalism of operators localized on shocks. We compute the probability distribution functions of the trajectories although they do not define Markov processes. As physically expected, these trajectories are statistically well-defined but collapse with probability one at infinite time. We point out that the advected scalars enjoy inverse energy cascades. We also make a few comments on the connection between our computations and persistence problems.

  6. Sailing the deep blue sea of decaying Burgers turbulence

    Bauer, Michel; Bernard, Denis

    1999-07-01

    We study Lagrangian trajectories and scalar transport statistics in decaying Burgers turbulence. We choose velocity fields solutions of the inviscid Burgers equation whose probability distributions are specified by Kida's statistics. They are time-correlated, and neither time-reversal invariant nor Gaussian. We discuss in some detail the effect of shocks on trajectories and transport equations. We derive the inviscid limit of these equations using a formalism of operators localized on shocks. We compute the probability distribution functions of the trajectories although they do not define Markov processes. As physically expected, these trajectories are statistically well defined but collapse with probability one at infinite time. We point out that the advected scalars enjoy inverse energy cascades. We also make a few comments on the connection between our computations and persistence problems.

  7. Classical and Quantum Burgers Fluids: A Challenge for Group Analysis

    Philip Broadbridge

    2015-10-01

    Full Text Available The most general second order irrotational vector field evolution equation is constructed, that can be transformed to a single equation for the Cole–Hopf potential. The exact solution to the radial Burgers equation, with constant mass influx through a spherical supply surface, is constructed. The complex linear Schrödinger equation is equivalent to an integrable system of two coupled real vector equations of Burgers type. The first velocity field is the particle current divided by particle probability density. The second vector field gives a complex valued correction to the velocity that results in the correct quantum mechanical correction to the kinetic energy density of the Madelung fluid. It is proposed how to use symmetry analysis to systematically search for other constrained potential systems that generate a closed system of vector component evolution equations with constraints other than irrotationality.

  8. Intermittency in fractal Fourier hydrodynamics: Lessons from the Burgers equation.

    Buzzicotti, Michele; Biferale, Luca; Frisch, Uriel; Ray, Samriddhi Sankar

    2016-03-01

    We present theoretical and numerical results for the one-dimensional stochastically forced Burgers equation decimated on a fractal Fourier set of dimension D. We investigate the robustness of the energy transfer mechanism and of the small-scale statistical fluctuations by changing D. We find that a very small percentage of mode-reduction (D ≲ 1) is enough to destroy most of the characteristics of the original nondecimated equation. In particular, we observe a suppression of intermittent fluctuations for D < 1 and a quasisingular transition from the fully intermittent (D=1) to the nonintermittent case for D ≲ 1. Our results indicate that the existence of strong localized structures (shocks) in the one-dimensional Burgers equation is the result of highly entangled correlations amongst all Fourier modes. PMID:27078449

  9. Intermittency in Fractal Fourier Hydrodynamics: Lessons from the Burgers Equation

    Buzzicotti, Michele; Frisch, Uriel; Ray, Samriddhi Sankar

    2016-01-01

    We present theoretical and numerical results for the one-dimensional stochastically forced Burgers equation decimated on a fractal Fourier set of dimension $D$. We investigate the robustness of the energy transfer mechanism and of the small-scale statistical fluctuations by changing $D$. We find that a very small percentage of mode-reduction ($D \\lesssim 1$) is enough to destroy most of the characteristics of the original non-decimated equation. In particular, we observe a suppression of intermittent fluctuations for $D <1$ and a quasi-singular transition from the fully intermittent ($D=1$) to the non-intermittent case for $D \\lesssim 1$. Our results indicate that the existence of strong localized structures (shocks) in the one-dimensional Burgers equation is the result of highly entangled correlations amongst all Fourier modes.

  10. Power Series Solution for Solving Nonlinear Burgers-Type Equations

    E. López-Sandoval

    2015-01-01

    Full Text Available Power series solution method has been traditionally used to solve ordinary and partial linear differential equations. However, despite their usefulness the application of this method has been limited to this particular kind of equations. In this work we use the method of power series to solve nonlinear partial differential equations. The method is applied to solve three versions of nonlinear time-dependent Burgers-type differential equations in order to demonstrate its scope and applicability.

  11. Conservation laws of inviscid Burgers equation with nonlinear damping

    Abdulwahhab, Muhammad Alim

    2014-06-01

    In this paper, the new conservation theorem presented in Ibragimov (2007) [14] is used to find conservation laws of the inviscid Burgers equation with nonlinear damping ut+g(u)ux+λh(u)=0. We show that this equation is both quasi self-adjoint and self-adjoint, and use these concepts to simplify conserved quantities for various choices of g(u) and h(u).

  12. A weak Galerkin finite element method for Burgers' equation

    Chen, Yanli; Zhang, Tie

    2016-01-01

    We propose a weak Galerkin(WG) finite element method for solving the one-dimensional Burgers' equation. Based on a new weak variational form, both semi-discrete and fully-discrete WG finite element schemes are established and analyzed. We prove the existence of the discrete solution and derive the optimal order error estimates in the discrete $H^1$-norm and $L^2$-norm, respectively. Numerical experiments are presented to illustrate our theoretical analysis.

  13. Exact solutions of (3 + 1)-dimensional stochastic Burgers equation

    A generalized tan h function method is used for constructing exact travelling wave solutions of nonlinear stochastic partial differential equations. The main idea of this method is to take full advantage of the Riccati equation, which has more exact solutions. More Wick-type stochastic multiple soliton-like solutions and triangular periodic solutions are obtained for the (3 + 1)-dimensional Wick-type stochastic Burgers equation via Hermite transformation

  14. High Fat Diet Induces Adhesion of Platelets to Endothelium in Two Models of Dyslipidemia

    Gonzalez, Jaime; Donoso, Wendy; Díaz, Natalia; Albornoz, María Eliana; Huilcaman, Ricardo; Morales, Erik

    2014-01-01

    Cardiovascular diseases (CVD) represent about 30% of all global deaths. It is currently accepted that, in the atherogenic process, platelets play an important role, contributing to endothelial activation and modulation of the inflammatory phenomenon, promoting the beginning and formation of lesions and their subsequent thrombotic complications. The objective of the present work was to study using immunohistochemistry, the presence of platelets, monocytes/macrophages, and cell adhesion molecules (CD61, CD163, and CD54), in two stages of the atheromatous process. CF-1 mice fed a fat diet were used to obtain early stages of atheromatous process, denominated early stage of atherosclerosis, and ApoE−/− mice fed a fat diet were used to observe advanced stages of atherosclerosis. The CF-1 mice model presented immunostaining on endothelial surface for all three markers studied; the advanced atherosclerosis model in ApoE−/− mice also presented granular immunostaining on lesion thickness, for the same markers. These results suggest that platelets participate in atheromatous process from early stages to advance d stages. High fat diet induces adhesion of platelets to endothelial cells in vivo. These findings support studying the participation of platelets in the formation of atheromatous plate. PMID:25328689

  15. Nanobioprobe for the Determination of Pork Adulteration in Burger Formulations

    We report the development of a swine-specific hybrid nanobioprobe through a covalent integration of a fluorophore-labeled 27-nucleotide AluI-fragment of swine cytochrome b gene to a 3 nm gold nanoparticle for the determination of pork adulteration in processed meat products. We tested the probe to estimate adulterated pork in ready-to-eat pork-spiked beef burgers. The probe quantitatively detected 1-100% spiked pork in burger formulations with ≥90% accuracy. A plot of observed fluorescence against the known concentration of AluI-digested pork DNA targets generated a concave curve, demonstrating a power relationship (y=2.956x0.509) with a regression coefficient (R2) of 0.986. No cross-species detection was found in a standard set of pork, beef, chicken, mutton, and chevon burgers. The method is suitable for the determination of very short-length nucleic acid targets which cannot be estimated by conventional and real-time PCR but are essential for the determination of micro RNA in bio diagnostics and degraded DNA in forensic testing and food analysis.

  16. The generalized Burgers equation with and without a time delay

    Nejib Smaoui

    2004-01-01

    Full Text Available We consider the generalized Burgers equation with and without a time delay when the boundary conditions are periodic with period 2π. For the generalized Burgers equation without a time delay, that is, ut=vuxx−uux+u+h(x, 00, u(0,t=u(2π,t, u(x,0=u0(x, a Lyapunov function method is used to show boundedness and uniqueness of a steady state solution and global stability of the equation. As for the generalized time-delayed Burgers equation, that is, ut(x,t=vuxx(x,t−u(x,t−τux(x,t+u(x,t, 00, u(0,t=u(2π,t, t>0, u(x,s=u0(x,s, 0

  17. Asymptotics for the Korteweg-de Vries-Burgers Equation

    Nakao HAYASHI; Pavel I. NAUMKIN

    2006-01-01

    We study large time asymptotics of solutions to the Korteweg-de Vries-Burgers equation ut + uux - uxx + uxxx = 0, x ∈ R, t > 0.We are interested in the large time asymptotics for the case when the initial data have an arbitrary size. We prove that ifthe initial data u0 ∈ Hs (R) ∩L1 (R), where s > -1/2,then there exists a uniquesolution u (t,x) ∈ C∞ ((0, ∞);H∞ (R)) to the Cauchy problem for the Korteweg-de Vries-Burgers equation, which has asymptotics u (t) = t-1/2fM((·)t-1/2) + o(t-1/2) as t →∞, where fM is the self-similar solution for the Burgers equation. Moreover if xu0 (x) ∈ L1 (R),then the asymptotics are true u (t) = t-1/2fM((·)t-1/2) + O(t-1/2-γ),where γ∈ (0,1/2).

  18. The Inviscid, Compressible and Rotational, 2D Isotropic Burgers and Pressureless Euler-Coriolis Fluids; Theory and Illustrations

    Choquard, Philippe

    2013-01-01

    The coupling between dilatation and vorticity, two coexisting and fundamental processes in fluid dynamics is investigated here, in the simplest cases of inviscid 2D isotropic Burgers and pressureless Euler-Coriolis fluids respectively modeled by single vortices confined in compressible, local, inertial and global, rotating, environments. The field equations are established, inductively, starting from the equations of the characteristics solved with an initial Helmholtz decomposition of the velocity fields namely a vorticity free and a divergence free part and, deductively, by means of a canonical Hamiltonian Clebsch like formalism, implying two pairs of conjugate variables. Two vector valued fields are constants of the motion: the velocity field in the Burgers case and the momentum field per unit mass in the Euler-Coriolis one. Taking advantage of this property, a class of solutions for the mass densities of the fluids is given by the Jacobian of their sum with respect to the actual coordinates. Implementatio...

  19. Human neutrophil Fc receptor-mediated adhesion under flow: a hollow fibre model of intravascular arrest.

    D'Arrigo, C; Candal-Couto, J J; Greer, M; Veale, D J; Woof, J M

    1995-04-01

    Human polymorphonuclear cells (PMN) were found to adhere to a novel model of blood vessel wall-associated IgG. The internal surfaces of cellulose acetate hollow fibres, of comparable internal diameter to small blood vessels, were coated with normal serum human IgG, heat-aggregated IgG (HAIgG), laminin or fibrinogen. Under conditions of flow mimicking those in a small vessel, PMN were found to adhere markedly only to immunoglobulin-coated fibres. Arrest on HAIgG was inhibited by excess soluble IgG but not by bovine serum albumin (BSA), demonstrating that the adhesion was IgG-specific and presumably mediated by Fc gamma R on the PMN surface. Pre-adsorption of serum components onto HAIgG-coated fibres enhanced PMN arrest, due most probably to fixation of complement components by immobilized HAIgG, resulting in additional potential to entrap PMN via complement receptors such as CR3. Treatment of PMN with the regulatory neuropeptide substance P also enhanced adhesion to HAIgG-coated fibres and caused increased surface expression of Fc gamma RI, Fc gamma RII and Fc gamma RIII. A mouse cell line derived from L cells, hR4C6, stably transfected with human Fc gamma RII, was found to adhere under flow to HAIgG-coated fibres, whilst untransfected parent L cells did not. This adhesion was similarly inhibited by excess soluble IgG, confirming the capability of Fc gamma R to mediate cell arrest. The study strongly suggests that Fc gamma R may play an important role in intravascular PMN arrest and we speculate that in inflammatory diseases PMN may adhere via Fc gamma R to immobilized immunoglobulin on the vascular endothelium, with subsequent degranulation and tissue damage. PMID:7535210

  20. Modelling liquid crystal elastomers and potential application as a reversibly switchable adhesive

    Adams, James

    2013-03-01

    Liquid crystal elastomers (LCEs) are rubbery materials that composed of liquid crystalline polymers (LCPs) crosslinked into a network. The rod-like mesogens incorporated into the LCPs are have random orientations in the high temperature isotropic phase, but can adopt the canonical liquid crystalline phases as the temperature is lowered. Smectic liquid crystal elastomers have highly anisotropic mechanical behaviour. This arises in side chain smectic-A systems because the smectic layers behave as if they are embedded in the rubber matrix. The macroscopic mechanical behaviour of these solids is sensitive to the buckling of the layers, so is a multiscale problem. A coarse grained free energy that includes the fine-scale buckling of the layers has been developed, which enables continuum modelling of these systems. In the first part of this talk I present a model of the mechanical behaviour of side chain smectic elastomers. The properties of nematic LCEs, such as their high loss tangent, and mechanical strain hardening, might enable them to be used as reversibly switchable pressure sensitive adhesive (PSA). PSAs are typically made from viscoelastic polymers. The quality of their adhesion can be measured by the tack energy, which is the work required to separate two bodies. To obtain a high tack energy a PSA should be capable of a large strain. It should strain soften at low strain to produce crack blunting, and then strain harden at high strain to stiffen the fibrils formed late in the debonding process. I will present a model of the tack energy of weakly crosslinked nematic polymers. To describe the constitutive properties of this system the nematic dumbbell model of Maffettone et al. was used. This constutitive model was then combined with the block model of Yamaguchi et al. describing PSAs. It was found that the parallel orientation of the nematic has a higher tack energy than both the isotropic and the perpendicular director orientation. This work is supported by

  1. Ex Vivo and In Vivo Mice Models to Study Blastocystis spp. Adhesion, Colonization and Pathology: Closer to Proving Koch's Postulates

    Ajjampur, Sitara S. R.; Png, Chin Wen; Chia, Wan Ni; Zhang, Yongliang; Tan, Kevin S. W.

    2016-01-01

    Blastocystis spp. are widely prevalent extra cellular, non-motile anerobic protists that inhabit the gastrointestinal tract. Although Blastocystis spp. have been associated with gastrointestinal symptoms, irritable bowel syndrome and urticaria, their clinical significance has remained controversial. We established an ex vivo mouse explant model to characterize adhesion in the context of tissue architecture and presence of the mucin layer. Using confocal microscopy with tissue whole mounts and two axenic isolates of Blastocystis spp., subtype 7 with notable differences in adhesion to intestinal epithelial cells (IEC), isolate B (ST7-B) and isolate H (more adhesive, ST7-H), we showed that adhesion is both isolate dependent and tissue trophic. The more adhesive isolate, ST7-H was found to bind preferentially to the colon tissue than caecum and terminal ileum. Both isolates were also found to have mucinolytic effects. We then adapted a DSS colitis mouse model as a susceptible model to study colonization and acute infection by intra-caecal inoculation of trophic Blastocystis spp.cells. We found that the more adhesive isolate ST7-H was also a better colonizer with more mice shedding parasites and for a longer duration than ST7-B. Adhesion and colonization was also associated with increased virulence as ST7-H infected mice showed greater tissue damage than ST7-B. Both the ex vivo and in vivo models used in this study showed that Blastocystis spp. remain luminal and predominantly associated with mucin. This was further confirmed using colonic loop experiments. We were also successfully able to re-infect a second batch of mice with ST7-H isolates obtained from fecal cultures and demonstrated similar histopathological findings and tissue damage thereby coming closer to proving Koch’s postulates for this parasite. PMID:27508942

  2. Numerical solutions of the generalized Burgers-Huxley equation by implicit exponential finite difference method

    İnan B.; Bahadir A. R.

    2015-01-01

    In this paper, numerical solutions of the generalized Burgers-Huxley equation are obtained using a new technique of forming improved exponential finite difference method. The technique is called implicit exponential finite difference method for the solution of the equation. Firstly, the implicit exponential finite difference method is applied to the generalized Burgers-Huxley equation. Since the generalized Burgers-Huxley equation is nonlinear the scheme leads to a system of nonlinear equatio...

  3. Analytical model of asymmetrical Mixed-Mode Bending test of adhesively bonded GFRP joint

    M. Ševčík

    2015-10-01

    Full Text Available This paper presents new analytical model of asymmetric mixed-mode bending (MMB specimen of adhesively bonded pultruded GFRP joints. An easily applicable relationship for the calculation of the strain energy release rate of the asymmetric MMB specimens is proposed based on the beam theory. The model is capable to analyze stacking sequence as well as various crack propagation paths. In the paper the effect of the various fiber bridging length and different crack propagation paths is analyzed analytically and supported by experimental results. The methodology and results presented in this paper could be utilized for the design of both joint geometry and lay-up of the laminates constituting the joint or for the prediction of the fracture behavior of such structures.

  4. Cohesive zone modelling of interface fracture near flaws in adhesive joints

    Hansen, Peter Feraren; Jensen, Henrik Myhre

    2004-01-01

    of crack propagation on the location and shape of the crack front and on the initial joint strength. Subsequently, the cohesive zone model is used to model interface fracture through a planar adhesive layer containing a periodic array of elliptical flaws. The effects of flaw shape are investigated......, as well as the significance of fracture process parameters. The results from simulations of fracture in a bond containing circular flaws show that localization of crack propagation in the vicinity of a flaw has significant effect on the joint strength and crack front shape. The localization effects...... are highly dependent on the fracture process zone width relative to the flaw dimensions. It is also seen that with increasing fracture process zone width, the strength variation with the flaw shape decreases, however, the strength is effected over a wider range of propagation, (C) 2004 Elsevier Ltd...

  5. Experimental simulation of model platelet adhesion to a semi-permeable wall exposed to flow disturbance

    DENG Xiaoyan; WANG Guixue; YANG Yang

    2003-01-01

    A sudden tubular expansion with a semi- permeable wall was constructed from a tubular dialysis membrane to investigate the effects of filtration flow and flow disturbance on particle deposition. The expansion was perfused with a dilute, neutrally buoyant suspension of 1.10 ?m diameter polystyrene latex spheres (as models of platelets) in Tris buffer solution containing 10% Dextran T70 and 2% bovine serum albumin. The results showed that adhesion of particles correlated positively with the filtration rate and inversely with the wall shear rate. In the vortex flow region distal to the expansion, particle adhesion was significantly elevated with a maximum at the reattachment point where the wall shear rate was the lowest and particles were constantly carried toward the vessel wall along the curved streamlines. In conclusion, filtration flow has a profound impact on the interaction of blood cells such as platelets with blood vessel walls, and the disturbed flow with a low wall shear rate can enhance the deposits of platelet thrombi to the vessel wall.

  6. Burgers equation with no-flux boundary conditions and its application for complete fluid separation

    Watanabe, Shinya; Matsumoto, Sohei; Higurashi, Tomohiro; Ono, Naoki

    2016-09-01

    Burgers equation in a one-dimensional bounded domain with no-flux boundary conditions at both ends is proven to be exactly solvable. Cole-Hopf transformation converts not only the governing equation to the heat equation with an extra damping but also the nonlinear mixed boundary conditions to Dirichlet boundary conditions. The average of the solution v bar is conserved. Consequently, from an arbitrary initial condition, solutions converge to the equilibrium solution which is unique for the given v bar. The problem arises naturally as a continuum limit of a network of certain micro-devices. Each micro-device imperfectly separates a target fluid component from a mixture of more than one component, and its input-output concentration relationships are modeled by a pair of quadratic maps. The solvability of the initial boundary value problem is used to demonstrate that such a network acts as an ideal macro-separator, separating out the target component almost completely. Another network is also proposed which leads to a modified Burgers equation with a nonlinear diffusion coefficient.

  7. Directional distribution of Burgers vectors of dislocation loops in ion-implanted silicon

    The possible directional distributions of Burgers vectors of perfect dislocation loops and dipoles formed in the silicon single crystals after ion implantation and annealing have been studied. (author)

  8. A systemic review of randomized controlled studies about prevention with pharmacologic agents of adhesion formation in the rat uterine horn model

    Oner, Gokalp; Ulug, Pasa

    2015-01-01

    Introduction Evaluation of treatment attempts in postoperative adhesion formation is pivotal for the prevention of several morbidities including infertility, pelvic pain, bowel obstruction, and subsequent intraoperative complications. The purpose of this systemic review was to assess the literature on the rat uterine horn model for adhesion formation and treatment modalities to prevent adhesion in the most frequently used experimental animal model. Material and methods We performed a systemic...

  9. Composites containing albumin protein or cyanoacrylate adhesives and biodegradable scaffolds: II. In vivo wound closure study in a rat model

    McNally-Heintzelman, Karen M.; Heintzelman, Douglas L.; Duffy, Mark T.; Bloom, Jeffrey N.; Soller, Eric C.; Gilmour, Travis M.; Hoffman, Grant T.; Edward, Deepak

    2004-07-01

    Our Scaffold-Enhanced Biological Adhesive (SEBA) system was investigated as an alternative to sutures or adhesives alone for repair of wounds. Two scaffold materials were investigated: (i) a synthetic biodegradable material fabricated from poly(L-lactic-co-glycolic acid); and (ii) a biologic material, small intestinal submucosa, manufactured by Cook BioTech. Two adhesive materials were also investigated: (i) a biologic adhesive composed of 50%(w/v) bovine serum albumin solder and 0.5mg/ml indocyanine green dye mixed in deionized water, and activated with an 808-nm diode laser; and (ii) Ethicon"s Dermabond, a 2-octyl-cyanoacrylate. The tensile strength and time-to-failure of skin incisions repaired in vivo in a rat model were measured at seven days postoperative. Incisions closed by protein solder alone, by Dermabond alone, or by suture, were also tested for comparison. The tensile strength of repairs formed using the SEBA system were 50% to 65% stronger than repairs formed by suture or either adhesive alone, with significantly less variations within each experimental group (average standard deviations of 15% for SEBA versus 38% for suture and 28% for adhesive alone). In addition, the time-to-failure curves showed a longevity not previously seen with the suture or adhesive alone techniques. The SEBA system acts to keep the dermis in tight apposition during the critical early phase of wound healing when tissue gaps are bridged by scar and granulation tissue. It has the property of being more flexible than either of the adhesives alone and may allow the apposed edges to move in conjunction with each other as a unit for a longer period of time and over a greater range of stresses than adhesives alone. This permits more rapid healing and establishment of integrity since the microgaps between the dermis edges are significantly reduced. By the time the scaffolds are sloughed from the wound site, there is greater strength and healing than that produced by adhesive alone or

  10. Thermosensitive hydrogel containing dexamethasone micelles for preventing postsurgical adhesion in a repeated-injury model

    Qinjie Wu; Ning Wang; Tao He; Jinfeng Shang; Ling Li; Linjiang Song; Xi Yang; Xia Li; Na Luo; Wenli Zhang; Changyang Gong

    2015-01-01

    Tissue adhesion is a common complication after surgery. In this work, a dexamethasone loaded polymeric micelles in thermosensitive hydrogel composite (Dex hydrogel) was prepared, which combined the anti-adhesion barrier with controlled release of anti-adhesion drug. Dexamethasone (Dex) was encapsulated in polymeric micelles (Dex micelles), and then the Dex micelles were loaded into biodegradable and thermosensitive hydrogel. The obtained Dex hydrogel showed a temperature-dependent sol-gel-sol...

  11. Effect of carbodiimide-derivatized hyaluronic acid gelatin on preventing postsurgical intra-abdominal adhesion formation and promoting healing in a rat model.

    Yuan, Fang; Lin, Long-Xiang; Zhang, Hui-Hui; Huang, Dan; Sun, Yu-Long

    2016-05-01

    Adhesions often occur after abdominal surgery. It could cause chronic pelvic pain, intestinal obstruction, and infertility. A hydrogel biomaterial, carbodiimide-derivatized hyaluronic acid gelatin (cd-HA gelatin), has been successfully used to reduce adhesion formation after flexor tendon grafting. This study investigated the efficacy of cd-HA gelatin in preventing postsurgical peritoneal adhesions in a rat model. The surgical traumas were created on the underlying muscle of the abdominal wall and the serosal layer of the cecum. The wounds were covered with or without cd-HA gelatin. Animals were euthanized at day 14 after surgery. Adhesion formation was assessed with adhesion degree and adhesion breaking strength. The healing of abdominal wall was evaluated with biomechanical testing and histological analysis. The adhesions occurred in all rats (n = 12) without cd-HA gelatin treatment. The application of cd-HA gelatin significantly reduced the adhesion rate from 100% to 58%. The decrease of adhesion breaking strength also manifested that cd-HA gelatin could reduce postsurgical intra-abdominal adhesion formation. Moreover, it was found that cd-HA gelatin was a safe material and could promote tissue healing. The cd-HA gelatin hydrogel could reduce the formation of intra-abdominal adhesions without adversely effects on wound healing. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 1175-1181, 2016. PMID:26749008

  12. Computational modeling reveals that a combination of chemotaxis and differential adhesion leads to robust cell sorting during tissue patterning.

    Tan, Rui Zhen; Chiam, Keng-Hwee

    2014-01-01

    Robust tissue patterning is crucial to many processes during development. The "French Flag" model of patterning, whereby naïve cells in a gradient of diffusible morphogen signal adopt different fates due to exposure to different amounts of morphogen concentration, has been the most widely proposed model for tissue patterning. However, recently, using time-lapse experiments, cell sorting has been found to be an alternative model for tissue patterning in the zebrafish neural tube. But it remains unclear what the sorting mechanism is. In this article, we used computational modeling to show that two mechanisms, chemotaxis and differential adhesion, are needed for robust cell sorting. We assessed the performance of each of the two mechanisms by quantifying the fraction of correct sorting, the fraction of stable clusters formed after correct sorting, the time needed to achieve correct sorting, and the size variations of the cells having different fates. We found that chemotaxis and differential adhesion confer different advantages to the sorting process. Chemotaxis leads to high fraction of correct sorting as individual cells will either migrate towards or away from the source depending on its cell type. However after the cells have sorted correctly, there is no interaction among cells of the same type to stabilize the sorted boundaries, leading to cell clusters that are unstable. On the other hand, differential adhesion results in low fraction of correct clusters that are more stable. In the absence of morphogen gradient noise, a combination of both chemotaxis and differential adhesion yields cell sorting that is both accurate and robust. However, in the presence of gradient noise, the simple combination of chemotaxis and differential adhesion is insufficient for cell sorting; instead, chemotaxis coupled with delayed differential adhesion is required to yield optimal sorting. PMID:25302949

  13. Diffusive approximation of a time-fractional Burgers equation in nonlinear acoustics

    Lombard, Bruno

    2016-01-01

    A fractional time derivative is introduced into the Burgers equation to model losses of nonlinear waves. This term amounts to a time convolution product, which greatly penalizes the numerical modeling. A diffusive representation of the fractional derivative is adopted here, replacing this nonlocal operator by a continuum of memory variables that satisfy local-in-time ordinary differential equations. Then a quadrature formula yields a system of local partial differential equations, well-suited to numerical integration. The determination of the quadrature coefficients is crucial to ensure both the well-posedness of the system and the computational efficiency of the diffusive approximation. For this purpose, optimization with constraint is shown to be a very efficient strategy. Strang splitting is used to solve successively the hyperbolic part by a shock-capturing scheme, and the diffusive part exactly. Numerical experiments are proposed to assess the efficiency of the numerical modeling, and to illustrate the e...

  14. Inverting Glacial Isostatic Adjustment with Paleo Sea Level Records using Bayesian Framework and Burgers Rheology

    Caron, L.; Metivier, L.; Greff-Lefftz, M.; Fleitout, L.; Rouby, H.

    2015-12-01

    Glacial Isostatic Adjustment models most often assume a mantle with a viscoelastic Maxwell rheology and a given ice history model. Here we use a Bayesian Monte Carlo with Markov Chains formalism to invert the global GIA signal simultaneously for the mechanical properties of the mantle and for the volume of the various ice-sheets using as starting ice models two distinct previously published ice histories. Burgers as well as Maxwell rheologies are considered.The fitted data consist of 5720 paleo sea level records from the last 35kyrs, with a world-wide distribution. Our ambition is to present not only the best fitting model, but also the range of possible solutions (within the explored space of parameters) with their respective probability of explaining the data, and thus reveal the trade-off effects and range of uncertainty affecting the parameters. Our a posteriori probality maps exhibit in all cases two distinct peaks: both are characterized by an upper mantle viscosity around 5.1020Pa.s but one of the peaks features a lower mantle viscosity around 3.1021Pa.s while the other indicates lower mantle viscosity of more than 1.1022Pa.s. The global maximum depends upon the starting ice history and the chosen rheology: the first peak (P1) has the highest probability only in the case with a Maxwell rheology and ice history based on ICE-5G, while the second peak (P2) is favored when using ANU-based ice history or Burgers rheology, and is our preferred solution as it is also consistent with long-term geodynamics and gravity gradients anomalies over Laurentide. P2 is associated with larger volumes for the Laurentian and Fennoscandian ice-sheets and as a consequence of total ice volume balance, smaller volumes for the Antactic ice-sheet. This last point interfers with the estimate of present-day ice-melting in Antarctica from GRACE data. Finally, we find that P2 with Burgers rheology favors the existence of a tectosphere, i.e. a viscous sublithospheric layer.

  15. Some More Solutions of Burgers' Equation

    In this work, similarity solutions of viscous one-dimensional Burgers' equation are attained by using Lie group theory. The symmetry generators are used for constructing Lie symmetries with commuting infinitesimal operators which lead the governing partial differential equation (PDE) to ordinary differential equation (ODE). Most of the constructed solutions are found in terms of Bessel functions which are new as far as authors are aware. Effect of various parameters in the evolutional profile of the solutions are shown graphically and discussed them physically

  16. Asymptotic Theory for the Probability Density Functions in Burgers Turbulence

    Weinan, E; Eijnden, Eric Vanden

    1999-01-01

    A rigorous study is carried out for the randomly forced Burgers equation in the inviscid limit. No closure approximations are made. Instead the probability density functions of velocity and velocity gradient are related to the statistics of quantities defined along the shocks. This method allows one to compute the anomalies, as well as asymptotics for the structure functions and the probability density functions. It is shown that the left tail for the probability density function of the velocity gradient has to decay faster than $|\\xi|^{-3}$. A further argument confirms the prediction of E et al., Phys. Rev. Lett. {\\bf 78}, 1904 (1997), that it should decay as $|\\xi|^{-7/2}$.

  17. Approximate solutions of general perturbed KdV-Burgers equations

    Baojian Hong

    2014-09-01

    Full Text Available In this article, we present some approximate analytical solutions to the general perturbed KdV-Burgers equation with nonlinear terms of any order by applying the homotopy analysis method (HAM. While compared with the Adomain decomposition method (ADM and the homotopy perturbation method (HPM, the HAM contains the auxiliary convergence-control parameter $\\hbar$ and the control function $H(x,t$, which provides a useful way to adjust and control the convergence region of solution series. The numerical results reveal that HAM is accurate and effective when it is applied to the perturbed PDEs.

  18. Burger King in Portugal : to lead or to follow?

    Patrone, Sara Saraiva

    2012-01-01

    In 2001, the Burger King (BK) brand, managed by Ibersol group entered the growing fast food Portuguese market. Marginally higher prices along with the fact of having entered the market 10 years after its most direct competitor (McDonald´s), led BK to a sub leader position. Although being recognized as offering superior quality products when compared to McDonald´s, BK´s growth margins in the Portuguese market have been decreasing since 2007. The company´s uncertainty situation, offers the p...

  19. Three-dimensional multi-scale model of deformable platelets adhesion to vessel wall in blood flow.

    Wu, Ziheng; Xu, Zhiliang; Kim, Oleg; Alber, Mark

    2014-08-01

    When a blood vessel ruptures or gets inflamed, the human body responds by rapidly forming a clot to restrict the loss of blood. Platelets aggregation at the injury site of the blood vessel occurring via platelet-platelet adhesion, tethering and rolling on the injured endothelium is a critical initial step in blood clot formation. A novel three-dimensional multi-scale model is introduced and used in this paper to simulate receptor-mediated adhesion of deformable platelets at the site of vascular injury under different shear rates of blood flow. The novelty of the model is based on a new approach of coupling submodels at three biological scales crucial for the early clot formation: novel hybrid cell membrane submodel to represent physiological elastic properties of a platelet, stochastic receptor-ligand binding submodel to describe cell adhesion kinetics and lattice Boltzmann submodel for simulating blood flow. The model implementation on the GPU cluster significantly improved simulation performance. Predictive model simulations revealed that platelet deformation, interactions between platelets in the vicinity of the vessel wall as well as the number of functional GPIbα platelet receptors played significant roles in platelet adhesion to the injury site. Variation of the number of functional GPIbα platelet receptors as well as changes of platelet stiffness can represent effects of specific drugs reducing or enhancing platelet activity. Therefore, predictive simulations can improve the search for new drug targets and help to make treatment of thrombosis patient-specific. PMID:24982253

  20. Adhesion of DOPA-Functionalized Model Membranes to Hard and Soft Surfaces.

    Guvendiren, Murat; Brass, David A; Messersmith, Phillip B; Shull, Kenneth R

    2009-01-01

    The adhesive proteins secreted by marine mussels form a natural glue that cures rapidly to form strong and durable bonds in aqueous environments. These mussel adhesive proteins contain an unusual amino acid, 3,4-dihydroxy-L-phenylalanine (DOPA), which is largely responsible for their cohesive and adhesive strengths. In this study, we incorporated DOPA into diblock and triblock polymers and developed a membrane contact experiment to assess the adhesive interactions of these materials with TiO(2) and tissue surfaces. In a typical experiment a micrometer-thick DOPA-functionalized elastomeric membrane is attached to the end of a cylindrical glass tube. Application of a positive pressure to the tube brings the membrane into contact with the surface of interest. The negative pressure needed to separate the membrane from the substrate is a measure of the strength of the adhesive interaction. The test confirms previous results obtained with TiO(2) substrates. Because the membrane geometry is well suited for rough or chemically heterogeneous surfaces, it is ideal for studies of tissue adhesion. DOPA was found to give strong adhesion to tissue surfaces, with the strongest adhesion obtained when the DOPA groups were oxidized while in contact with the tissue surface. PMID:21461121

  1. Some remarks on Li-Sinai-type solutions of the Burgers equation

    Pauls, W.

    2011-07-01

    For a class of complex-valued initial conditions, we construct solutions for the inviscid Burgers equations of the same type as those recently introduced by Li and Sinai. Obtained by very simple considerations, these solutions correspond to stable distributions with 1 Gaussian type can be constructed for the viscous Burgers equation.

  2. Discrete Symmetries Analysis and Exact Solutions of the Inviscid Burgers Equation

    Hongwei Yang

    2012-01-01

    Full Text Available We discuss the Lie point symmetries and discrete symmetries of the inviscid Burgers equation. By employing the Lie group method of infinitesimal transformations, symmetry reductions and similarity solutions of the governing equation are given. Based on discrete symmetries analysis, two groups of discrete symmetries are obtained, which lead to new exact solutions of the inviscid Burgers equation.

  3. On the solution of two-dimensional coupled Burgers' equations by variational iteration method

    By means of variational iteration method the solutions of two-dimensional Burgers' and inhomogeneous coupled Burgers' equations are exactly obtained, comparison with the Adomian decomposition method is made, showing that the former is more effective than the later. In this paper, He's variational iteration method is given approximate solutions that can converge to its exact solutions faster than those of Adomain's method.

  4. Adhesive Categories

    Lack, Stephen; Sobocinski, Pawel

    2003-01-01

    We introduce adhesive categories, which are categories with structure ensuring that pushouts along monomorphisms are well-behaved. Many types of graphical structures used in computer science are shown to be examples of adhesive categories. Double-pushout graph rewriting generalises well to...... rewriting on arbitrary adhesive categories....

  5. Adhesive Categories

    Lack, Stephen; Sobocinski, Pawel

    2004-01-01

    We introduce adhesive categories, which are categories with structure ensuring that pushouts along monomorphisms are well-behaved. Many types of graphical structures used in computer science are shown to be examples of adhesive categories. Double-pushout graph rewriting generalises well to...... rewriting on arbitrary adhesive categories....

  6. Evaluation of the Effectiveness of Peritoneal Adhesion Prevention Devices in a Rat Model

    Poehnert, D; Grethe, L; Maegel, L; Jonigk, D; Lippmann, T; Kaltenborn, A; Schrem, H; Klempnauer, J; Winny, M

    2016-01-01

    Background: Abdominal operations are followed by adhesions, a prevalent cause of abdominal pain, and the most frequent cause for bowel obstruction and secondary female infertility. This rat study addresses adhesion prevention capability of Adept®, Interceed®, Seprafilm®, and a novel device, 4DryField® PH which is provided as powder and generates its effect as gel. Methods: Sixty-eight male Lewis rats had cecal abrasion and creation of an equally sized abdominal wall defect, and were grouped randomly: A control group without treatment (n=10); two groups treated with 4DryField® PH using premixed gel (n=15) or in-situ gel technique (n=16); one group each was treated with Seprafilm® (n=8), Interceed® (n=9), or Adept® (n=10). Sacrifice was on day 7 to evaluate incidence, quality, and quantity of adhesions, as expressed via adhesion reduction rate (AR). Histologic specimens were evaluated. Statistical analyses used ANOVA and unpaired t-tests. Results: 4DryField® PH significantly reduced incidence and severity of adhesions both as premixed gel (AR: 85.2%) and as in-situ made gel (AR: 100%), a comparison between these two application techniques showed no differences in efficacy. Seprafilm® did not reduce incidence but severity of adhesions significantly (AR: 53.5%). With Interceed® (AR: 3.7%) and Adept® (AR: 16.1%) no significant adhesion-reduction was achieved. Except for inflammatory response with Interceed®, histopathology showed good tissue compatibility of all other devices. Conclusion: 4DryField® PH and Seprafilm® showed significant adhesion prevention capabilities. 4DryField® PH achieved the highest adhesion prevention effectiveness without restrictions concerning mode of application and compatibility and, thus, is a promising strategy to prevent abdominal adhesions. PMID:27429589

  7. Surface conductivity of insulators: one-dimensional initial value problems and the inviscid Burgers equation

    A generalized derivation of the equations governing surface carrier diffusion in the surface region of an insulator is presented, based on the Mott-Gurney model of ionic diffusion as first proposed in Liesegang et al (1995 J. Appl. Phys. 77 5782; 1996 J. Appl. Phys. 80 6336). The resulting non-linear equations are decoupled for the case of one-dimensional diffusion and we show that the decay of the electric field is described by the inviscid Burgers equation. Imposing initial and boundary conditions reflecting the experimental configuration for a Cartesian system as discussed in Liesegang et al, a general solution for the carrier density in the surface of an insulating sample is derived for the case of one-dimensional charge motion

  8. Burgers-like equation for spontaneous breakdown of the chiral symmetry in QCD

    Blaizot, Jean-Paul; Warchoł, Piotr

    2013-01-01

    We link the spontaneous breakdown of chiral symmetry in Euclidean QCD to the collision of spectral shock waves in the vicinity of zero eigenvalue of Dirac operator. The mechanism, originating from complex Burger's-like equation for viscid, pressureless, one-dimensional flow of eigenvalues, is similar to recently observed weak-strong coupling phase transition in large $N_c$ Yang-Mills theory. The spectral viscosity is proportional to the inverse of the size of the random matrix that replaces the Dirac operator in the universal (ergodic) regime. We obtain the exact scaling function and critical exponents of the chiral phase transition for the averaged characteristic polynomial for $N_c \\ge3$ QCD. We reinterpret our results in terms of known properties of chiral random matrix models and lattice data.

  9. Burgers-like equation for spontaneous breakdown of the chiral symmetry in QCD

    We link the spontaneous breakdown of chiral symmetry in Euclidean QCD to the collision of spectral shock waves in the vicinity of zero eigenvalue of the Dirac operator. The mechanism, originating from complex Burger's-like equation for viscid, pressureless, one-dimensional flows of eigenvalues, is similar to the recently observed weak-strong coupling phase transition in large Nc Yang–Mills theory. The spectral viscosity is proportional to the inverse size of the random matrix that replaces the Dirac operator in the universal (ergodic) regime. We obtain the exact scaling function and critical exponents of the chiral phase transition for the averaged characteristic polynomial for Nc⩾3 QCD. We reinterpret our results in terms of known properties of chiral random matrix models and lattice data

  10. Modeling and design optimization of adhesion between surfaces at the microscale.

    Sylves, Kevin T. (University of Colorado, Boulder, CO)

    2008-08-01

    This research applies design optimization techniques to structures in adhesive contact where the dominant adhesive mechanism is the van der Waals force. Interface finite elements are developed for domains discretized by beam elements, quadrilateral elements or triangular shell elements. Example analysis problems comparing finite element results to analytical solutions are presented. These examples are then optimized, where the objective is matching a force-displacement relationship and the optimization variables are the interface element energy of adhesion or the width of beam elements in the structure. Several parameter studies are conducted and discussed.

  11. Effect of hyaluronic acid on postoperative intraperitoneal adhesion formation in the rat model

    Urman, B.; Gomel, V.; Jetha, N. (Department of Obstetrics and Gynecology, University of British Columbia, Vancouver (Canada))

    1991-09-01

    The aim of this study was to determine the effectiveness of hyaluronic acid solution in preventing intraperitoneal (IP) adhesions. The study design was prospective, randomized and blinded and involved 83 rats. Measured serosal injury was inflicted using a CO2 laser on the right uterine horn of the rat. Animals randomized to groups 1 and 2 received either 0.4% hyaluronic acid or its diluent phosphate-buffered saline (PBS) intraperitoneally before and after the injury. In groups 3 and 4, the same solutions were used only after the injury. Postoperative adhesions were assessed at second-look laparotomy. Histologic assessment of the fresh laser injury was carried out on uteri pretreated with hyaluronic acid, PBS, or nothing. Pretreatment with hyaluronic acid was associated with a significant reduction in postoperative adhesions and a significantly decreased crater depth. Hyaluronic acid appears to reduce postoperative IP adhesion formation by coating the serosal surfaces and decreasing the extent of initial tissue injury.

  12. Effect of hyaluronic acid on postoperative intraperitoneal adhesion formation and reformation in the rat model

    Urman, B.; Gomel, V. (Department of Obstetrics and Gynecology, University of British Columbia, Vancouver (Canada))

    1991-09-01

    The local application of 0.25% or 0.4% HA before the induction of a measured laser injury on the rat uterine horn was associated with a significant reduction (P less than 0.05) in postoperative IP adhesions when compared with the group of animals pretreated with the diluent vehicle PBS or received no pretreatment. However, 0.4% HA, when applied in a similar manner, was ineffective in reducing reformation of adhesions after microsurgical adhesiolysis.

  13. Experimental characterization and numerical simulation of composite adhesive joints using the cohesive zone model approach

    Sarrado Molina, Carlos

    2015-01-01

    The present thesis aims at developing robust numerical and experimental methods for the simulation of composite adhesive joints. Firstly, a new method for the experimental characterization of adhesive joints is presented. The proposed method widens the range of applicability of the existing methods at the same time that lowers the uncertainty of the results. By means of this method, a critical study on the validity of the existing experimental methods is presented, as well as the thorough cha...

  14. Staphylococcus aureus and Staphylococcus epidermidis adhesion to nanohydroxyapatite in the presence of model proteins

    Bacterial infections can have adverse effects on the efficacy, lifetime, and safety of an implanted device. The aim of this study was to investigate the initial adhesion of several strains, namely S. aureus and S. epidermidis, on two distinct types of nanohydroxyapatite (nanoHA), sintered at 725 °C and 1000 °C. A comparison was also made with nanohydroxyapatite having adsorbed fetal bovine serum (FBS), human fibronectin (FN) and human serum albumin (HSA). Adhered bacterial cells were examined by scanning electron microscopy and quantified as colony forming units after being released by sonication. The wettability of the sample surface with and without adsorbed protein was assessed by contact-angle measurements. NanoHA sintered at 1000 °C showed lower bacterial adhesion than this heat-treated at 725 °C. Adsorption of FBS onto the nanoHA surface caused a decrease in the adhesion of all strains on both materials. The bacterial adhesion patterns in the presence of FN were different for both nanoHA substrates; the adherence of the bacterial strains, except for the clinical strain of S. epidermidis, was significantly higher on nanoHA 1000 in comparison to nanoHA 1000 without protein and the bacterial adhesion on the FN-coated nanoHA 725 was lower in comparison to the bare nanoHA 725. The effect of HSA on bacterial adhesion was concentration and bacterial strain dependent. (paper)

  15. Real and Complex Turbulence for the Stochastic Burgers Equation

    Neate, A

    2004-01-01

    The inviscid limit of Burgers equation, with body forces white noise in time, is discussed in terms of the level surfaces of the minimising Hamilton-Jacobi function and the classical mechanical caustic. Presurfaces and precaustics are introduced by using the classical mechanical flow map. When the prelevel surface touches the precaustic, the geometry (number of cusps) on the level surface changes infinitely rapidly causing `real turbulence' (Davies, Truman and Zhao). Using an idea of Felix Klein, it is shown that the geometry (number of swallowtails) on the caustic also changes infinitely rapidly when the real part of the precaustic touches its complex counterpart, which we call `complex turbulence'. These two new kinds of turbulence are both inherently stochastic in nature. A complete analysis of this problem is given in terms of a reduced (one dimensional) action function. This characterises which parts of the original caustic are singular - an old problem in applied mathematics relevant for our `elementary...

  16. The Application of Hypoxanthine Activity as a Quality Indicator of Cold Stored Fish Burgers

    METİN, Suhendan; ERKAN, Nuray; VARLIK, Candan

    2002-01-01

    Seafoods are very perishable, and many different methods are used for the determination of their quality. Sensory and hypoxanthine values of cold stored trout burgers, which we prepared, were determined during a 28-day period. Burgers spoiled after the 21st day of storage. The TVB-N values were still very low when the burgers spoiled and the pH values decreased during their storage. Therefore total volatile bases nitrogen and pH analyses were not useful for the determination of the quality...

  17. QUALITY CHARACTERISTICS OF CHICKEN BURGERS ENRICHED WITH VEGETABLE OILS, INULIN AND WHEAT FIBER

    A. Cegielka

    2015-09-01

    Full Text Available The aim of the study was to modify the composition of chicken burgers in terms of nutritional value by substitution of 20% of pork jowl with a mixture of rapeseed oil and linseed oil, and addition of inulin (1% or wheat fiber (3%. Substitution of pork jowl with vegetable oils resulted in significant increase in polyunsaturated fatty acids, and rosemary extract retarded the oxidation process of lipids. Addition of wheat fiber was helpful in maintaining the thermal processing yield and texture of burgers. Microbiological quality of vacuum packed burgers subjected to 21-day storage at +4°C±1 and -20°C±1 was satisfactory.

  18. A numerical solution of the Burgers' equation using septic B-splines

    Ramadan, Mohamed A. [Department of Mathematics, Faculty of Science, Menoufia University, Shiben El-Koom (Egypt)] e-mail: mramadan@mailer.eun.eg; El-Danaf, Talaat S. [Department of Mathematics, Faculty of Science, Menoufia University, Shiben El-Koom (Egypt); Abd Alaal, Faisal E.I. [Department of Mathematics, Faculty of Science, Menoufia University, Shiben El-Koom (Egypt)

    2005-11-01

    In this paper, numerical solutions of the nonlinear Burgers' equation are obtained by a method based on collocation of septic B-splines over finite elements. Applying the Von-Neumann stability analysis, the proposed method is shown to be unconditionally stable. Numerical solutions of the modified Burgers' equation are also obtained by making a simple change of the suggested numerical scheme for the Burgers' equation. The accuracy of the presented method is demonstrated by two test problems. The numerical results are found to be in good agreement with the exact solutions.

  19. A numerical solution of the Burgers' equation using septic B-sp lines

    Ramadan, Mohamed A. [Department of Mathematics, Faculty of Science, Menoufia University, Shiben El-Koom (Egypt)] e-mail: mramadan@mailer.eun.eg; El-Danaf, Talaat S. [Department of Mathematics, Faculty of Science, Menoufia University, Shiben El-Koom (Egypt); Abd Alaal, Faisal E.I. [Department of Mathematics, Faculty of Science, Menoufia University, Shiben El-Koom (Egypt)

    2005-11-01

    In this paper, numerical solutions of the nonlinear Burgers' equation are obtained by a method based on collocation of septic B-sp lines over finite elements. Applying the Von-Neumann stability analysis, the proposed method is shown to be unconditionally stable. Numerical solutions of the modified Burgers' equation are also obtained by making a simple change of the suggested numerical scheme for the Burgers' equation. The accuracy of the presented method is demonstrated by two test problems. The numerical results are found to be in good agreement with the exact solutions.

  20. Reductions and conserved quantities for discrete compound KdV-Burgers equations

    He Yu-Fang; Liu Yong-Song; Fu Jing-Li

    2011-01-01

    We present two methods to reduce the discrete compound KdV-Burgers equation, which are reductions of the independent and dependent variables: the translational invariant method has been applied in order to reduce the independent variables; and a discrete spectral matrix has been introduced to reduce the number of dependent variables.Based on the invariance of a discrete compound KdV-Burgers equation under infinitesimal transformation with respect to its dependent and independent variables, we present the determining equations of transformation Lie groups for the KdV-Burgers equation and use the characteristic equations to obtain new forms of invariants.

  1. Dynamical arrest, percolation, gelation, and glass formation in model nanoparticle dispersions with thermoreversible adhesive interactions.

    Eberle, Aaron P R; Castañeda-Priego, Ramón; Kim, Jung M; Wagner, Norman J

    2012-01-24

    We report an experimental study of the dynamical arrest transition for a model system consisting of octadecyl coated silica suspended in n-tetradecane from dilute to concentrated conditions spanning the state diagram. The dispersion's interparticle potential is tuned by temperature affecting the brush conformation leading to a thermoreversible model system. The critical temperature for dynamical arrest, T*, is determined as a function of dispersion volume fraction by small-amplitude dynamic oscillatory shear rheology. We corroborate this transition temperature by measuring a power-law decay of the autocorrelation function and a loss of ergodicity via fiber-optic quasi-elastic light scattering. The structure at T* is measured using small-angle neutron scattering. The scattering intensity is fit to extract the interparticle pair-potential using the Ornstein-Zernike equation with the Percus-Yevick closure approximation, assuming a square-well interaction potential with a short-range interaction (1% of particle diameter). (1) The strength of attraction is characterized using the Baxter temperature (2) and mapped onto the adhesive hard sphere state diagram. The experiments show a continuous dynamical arrest transition line that follows the predicted dynamical percolation line until ϕ ≈ 0.41 where it subtends the predictions toward the mode coupling theory attractive-driven glass line. An alternative analysis of the phase transition through the reduced second virial coefficient B(2)* shows a change in the functional dependence of B(2)* on particle concentration around ϕ ≈ 0.36. We propose this signifies the location of a gel-to-glass transition. The results presented herein differ from those observed for depletion flocculated dispersion of micrometer-sized particles in polymer solutions, where dynamical arrest is a consequence of multicomponent phase separation, suggesting dynamical arrest is sensitive to the physical mechanism of attraction. PMID:22148874

  2. The effect of temperature on adhesion forces between surfaces and model foods containing whey protein and sugar

    Goode, K. R.; Bowen, J.; Akhtar, N; Robbins, P. T.; Fryer, P. J.

    2013-01-01

    The formation of fouling deposit from foods and food components is a severe problem in food processing and leads to frequent cleaning. The design of surfaces that resist fouling may decrease the need for cleaning and thus increase efficiency. Atomic force microscopy has been used to measure adhesion forces between stainless steel (SS) and fluoro-coated glass (FCG) microparticles and the model food deposits (i) whey protein (WPC), (ii) sweetened condensed milk, and (iii) caramel. Measurements ...

  3. Surgical adhesives

    I. A. THOMAZINI-SANTOS

    2001-12-01

    Full Text Available The authors have performed a literature review of surgical adhesives, such as cyanoacrylate, collagen gelatin, and fibrin glue. They have included different types of commercial and non-commercial fibrin sealants and have reported on the different components in these adhesives, such as fibrinogen, cryoprecipitate, bovine thrombin, and thrombin-like fraction of snake venom.

  4. Statistical properties of large ensembles of exact solutions to Burgers' equation with random initial conditions

    The study of Burgers' equation is important to the understanding of the Navier-Stokes equation, as Burgers' equation is so often used in preliminary investigations of turbulence (i.e., statistical closures). In this work, the difficulties in implementing exact solutions to Burgers' equation have been overcome, allowing the study of the statistical properties of Burgers' equation using the exact solution for piecewise linear initial velocity fields. The statistical and spectral properties commonly used in studies of turbulence are presented for three different types of initial conditions. It is found that the energy spectrum quickly evolves to a self-similar functional form which can be simply characterized. A full-spectrum nonlinear similarity transformation based on this characterization is developed. It is found that the probability distribution of the velocity field approaches a bell-shaped distribution, but that the higher moments of this distribution do not rapidly approach those of a Gaussian distribution

  5. PHYSICOCHEMICAL, MICROBIOLOGICAL QUALITY AND OXIDATIVE STABILITY IN SPICED LAMB MEAT BURGERS

    Almudena Cózar

    2013-12-01

    Full Text Available The effect of adding two powdered spices (rosemary and thyme on the pH, colour coordinates, Cooking yield (CY Cooking loss (CL, Diameter Reduction (DR, Shear Force (SF, microbiological levels and lipid oxidation (LO in two types of lamb burgers (L= leg meat; LNB= leg+neck+breast meat was assessed over a six day period. Both spices increased stability during the storage period, LO values being six times lower than those of the non-spiced control group at 6 days. L samples showed higher CY, lower CL and DR than LNB burgers, with significant differences at 6 d (P < 0.001. The length of storage only affected (P < 0.01 these parameters in L burgers. In general, SF was higher in LNB than in L burgers but did not vary with time. The colour coordinates showed lower values in L than in LNB samples. The formulation type affected TVC and Pseudomonas spp.

  6. New multi-soliton solutions for generalized Burgers-Huxley equation

    Liu Jun

    2013-01-01

    Full Text Available The double exp-function method is used to obtain a two-soliton solution of the generalized Burgers-Huxley equation. The wave has two different velocities and two different frequencies.

  7. Lactobacillus Adhesion to Mucus

    Maxwell L. Van Tassell

    2011-05-01

    Full Text Available Mucus provides protective functions in the gastrointestinal tract and plays an important role in the adhesion of microorganisms to host surfaces. Mucin glycoproteins polymerize, forming a framework to which certain microbial populations can adhere, including probiotic Lactobacillus species. Numerous mechanisms for adhesion to mucus have been discovered in lactobacilli, including partially characterized mucus binding proteins. These mechanisms vary in importance with the in vitro models studied, which could significantly affect the perceived probiotic potential of the organisms. Understanding the nature of mucus-microbe interactions could be the key to elucidating the mechanisms of probiotic adhesion within the host.

  8. Finite symmetry transformation group and localized structures of the (2+1)-dimensional coupled Burgers equation

    Lei Ya; Yang Duo

    2013-01-01

    In this paper,the finite symmetry transformation group of the (2+ 1)-dimensional coupled Burgers equation is studied by the modified direct method,and with the help of the truncated Painlevé expansion approach,some special localized structures for the (2+ 1)-dimensional coupled Burgers equation are obtained,in particular,the dromion-like and solitoff-like structures.

  9. PAINLEV PROPERTY OF BURGERS-KDV EQUATION AND ITS EXACT SOLUTIONS

    2010-01-01

    In this paper, we introduce the Painlev property of the Burgers-KdV equation. Two types of exact solutions to the equation are obtained by the standard truncated expansion metIn this paper, we introduce the Painlev property of the Burgers-KdV equation. Two types of exact solutions to the equation are obtained by the standard truncated expansion method and the extended standard truncated expansion method, respectively.hod and the extended standard truncated expansion method, respectively.

  10. Modelling the Interfacial Adhesion in Polyethylene/Polypropylene Blends Compatibilized by Means of Reactive Extrusion

    Gerard, J. F.; Kotek, Jiří; Colbeaux, A.; Fenouillot, F.; Wautier, H.

    University of Florida: American Chemical Society, 2002, s. 419-420. (PMSE Preprints.. 86). [Spring Meeting of the American Chemical Society, Division of Polymeric Materials: Science and Engineering. Orlando (US), 07.04.2002-11.04.2002] R&D Projects: GA AV ČR KSK4050111 Keywords : PP/HDPE blend * compatibilization * interfacial adhesion Subject RIV: CD - Macromolecular Chemistry

  11. Chemical Composition and Storage Stability of Beef burger Steaks as Influenced by Cooking and Irradiation

    Meat industry in Egypt has a great economic potential, but till now it has not received adequate attention. Beef burgers were prepared (50 g, 1 cm thick steaks) and aerobically packaged into polyethylene pages then divided into control, cooking and gamma-irradiated (3 and 4 kGy) groups. Samples stored at (5±degree c) and periodically judged after 5, 10, 15, 20,25 and 30 days. The results showed that irradiation increased the shelf life of stored cooked beef burger, as compared to control samples. In addition, the dose of 3 kGy is considered the most adequate for irradiation of this meat product because it obtained the same results reflected by 4 kGy. The microbiological, chemical and sensorial testing for stored cooking and irradiated beef burger steaks were examined according an experimental design presented conditions that were adequate for human consumption of this product during the refrigeration storage periods. For the non-irradiated beef burger samples, bacterial contamination was the main limiting factor with respect to the shelf life, whereas for the irradiated beef burger samples this factor was lipid oxidation. Conclusion: The cooking before food irradiation may be of practical efficacy in enhancing the technical effectiveness and feasibility of irradiation of a variety of meat products. Recommendation: The necessity for a proper preservation method for marketing the processing beef burger steaks in each of its numerous retail markets should be established central irradiation units for processing and packing before distribution in these retail markets

  12. A numerical model of a HIL scaled roller rig for simulation of wheel-rail degraded adhesion condition

    Conti, Roberto; Meli, Enrico; Pugi, Luca; Malvezzi, Monica; Bartolini, Fabio; Allotta, Benedetto; Rindi, Andrea; Toni, Paolo

    2012-05-01

    Scaled roller rigs used for railway applications play a fundamental role in the development of new technologies and new devices, combining the hardware in the loop (HIL) benefits with the reduction of the economic investments. The main problem of the scaled roller rig with respect to the full scale ones is the improved complexity due to the scaling factors. For this reason, before building the test rig, the development of a software model of the HIL system can be useful to analyse the system behaviour in different operative conditions. One has to consider the multi-body behaviour of the scaled roller rig, the controller and the model of the virtual vehicle, whose dynamics has to be reproduced on the rig. The main purpose of this work is the development of a complete model that satisfies the previous requirements and in particular the performance analysis of the controller and of the dynamical behaviour of the scaled roller rig when some disturbances are simulated with low adhesion conditions. Since the scaled roller rig will be used to simulate degraded adhesion conditions, accurate and realistic wheel-roller contact model also has to be included in the model. The contact model consists of two parts: the contact point detection and the adhesion model. The first part is based on a numerical method described in some previous studies for the wheel-rail case and modified to simulate the three-dimensional contact between revolute surfaces (wheel-roller). The second part consists in the evaluation of the contact forces by means of the Hertz theory for the normal problem and the Kalker theory for the tangential problem. Some numerical tests were performed, in particular low adhesion conditions were simulated, and bogie hunting and dynamical imbalance of the wheelsets were introduced. The tests were devoted to verify the robustness of control system with respect to some of the more frequent disturbances that may influence the roller rig dynamics. In particular we verified

  13. A brand loyalty model for arts festivals / Susanna Elizabeth Burger

    Burger, Susanna Elizabeth

    2015-01-01

    The number of festivals and events worldwide as well as in South Africa has increased significantly over the past decade. With more than 600 festivals being staged annually in South Africa, it is clear that festivals are competing with each other to attract and retain visitors in order to remain sustainable. For this reason, creating and sustaining a loyal visitor base through marketing and branding activities has become increasingly important for festivals. This, however, is a complex task s...

  14. Analytical modeling of mixed-Mode bending behavior of asymmetric adhesively bonded pultruded GFRP joints

    Ševčík, Martin; Shahverdi, M.; Hutař, Pavel; Vassilopoulos, Anastasios P.

    2015-01-01

    Roč. 147, OCT (2015), s. 228-242. ISSN 0013-7944 R&D Projects: GA MŠk(CZ) ED1.1.00/02.0068; GA MŠk(CZ) EE2.3.30.0063 Institutional support: RVO:68081723 Keywords : Mixed-Mode delamination * Asymmetric joint * Adhesively bonded joint * Failure criterion * Analytical prediction * GFRP Subject RIV: JL - Materials Fatigue, Friction Mechanics Impact factor: 1.767, year: 2014

  15. Nonempirical potentials in modelling of boron adhesion on a (110) tungsten surface

    Dorfman, S; Mundim, K C; Fuks, D; Gordon, A; Felsteiner, J

    2003-01-01

    We have performed the atomistic simulations of the adhesion process of a boron atom on a tungsten(110) surface on the basis of the generalized simulation annealing formalism. The interatomic potentials used in these simulations were obtained from ab initio total energy calculations on the basis of the recursion procedure. The nonempirical calculations have been carried out in the framework of density functional theory in the coherent potential approximation.

  16. Damage modelling procedure and fastener positioning optimization of adhesively reinforced frictional interfaces

    Oinonen, Ahti

    2011-01-01

    This thesis is concerned with the development of the shear damage simulation procedure for combined mechanically clamped and adhesively reinforced frictional joint interfaces. The first step has been to experimentally measure the shear fracture behaviour of high strength steel interfaces using annular ring specimens subject to constant normal pre-stress. The experimental programme included variations of the pre-stress, surface roughness and epoxy curing temperature. Results showed that these ...

  17. Impairment of the Peritoneal Surface as a Decisive Factor for Intestinal Adhesions in Intraperitoneal Onlay Mesh Surgery - Introducing a New Rat Model

    Winny, M; Grethe, L; Maegel, L; Jonigk, D; Lippmann, T.; Klempnauer, J; Poehnert, D

    2016-01-01

    Background: Meshes implanted intraperitoneally are known to cause adhesions potentially resulting in complications such as chronic pain, enterocutaneous fistula, or mesh infection. This study introduces a model for investigation of intestine-to-mesh adhesions and evaluates as to whether missing of visceral peritoneum is causative. Methods: In 18 rats, rectangular 1.5 x 2 cm patches of an uncoated polypropylene mesh (Ultrapro®) were sewn to the inner abdominal wall next to the cecum. Additiona...

  18. Creep curve measurement to support wear and adhesion modelling, using a continuously variable creep twin disc machine

    Fletcher, D. I.; Lewis, S.

    2013-01-01

    Predictive modelling of wear and adhesion at rolling-sliding contacts such as a railway rail and wheel depends on understanding the relationship between slip and shear force at the contact surface, i.e. the creep verses force curve. This paper describes a new approach to creep curve measurement using a twin disc machine running with a continuous programmed variation of creep, enabling an entire creep curve to be defined in a single experiment. The work focuses on very low levels of creep, ran...

  19. Stokes' second problem for magnetohydrodynamics flow in a Burgers' fluid: the cases γ = λ²/4 and γ>λ²/4.

    Ilyas Khan

    Full Text Available The present work is concerned with exact solutions of Stokes second problem for magnetohydrodynamics (MHD flow of a Burgers' fluid. The fluid over a flat plate is assumed to be electrically conducting in the presence of a uniform magnetic field applied in outward transverse direction to the flow. The equations governing the flow are modeled and then solved using the Laplace transform technique. The expressions of velocity field and tangential stress are developed when the relaxation time satisfies the condition γ =  λ²/4 or γ> λ²/4. The obtained closed form solutions are presented in the form of simple or multiple integrals in terms of Bessel functions and terms with only Bessel functions. The numerical integration is performed and the graphical results are displayed for the involved flow parameters. It is found that the velocity decreases whereas the shear stress increases when the Hartmann number is increased. The solutions corresponding to the Stokes' first problem for hydrodynamic Burgers' fluids are obtained as limiting cases of the present solutions. Similar solutions for Stokes' second problem of hydrodynamic Burgers' fluids and those for Newtonian and Oldroyd-B fluids can also be obtained as limiting cases of these solutions.

  20. Stokes' second problem for magnetohydrodynamics flow in a Burgers' fluid: the cases γ = λ²/4 and γ>λ²/4.

    Khan, Ilyas; Ali, Farhad; Shafie, Sharidan

    2013-01-01

    The present work is concerned with exact solutions of Stokes second problem for magnetohydrodynamics (MHD) flow of a Burgers' fluid. The fluid over a flat plate is assumed to be electrically conducting in the presence of a uniform magnetic field applied in outward transverse direction to the flow. The equations governing the flow are modeled and then solved using the Laplace transform technique. The expressions of velocity field and tangential stress are developed when the relaxation time satisfies the condition γ =  λ²/4 or γ> λ²/4. The obtained closed form solutions are presented in the form of simple or multiple integrals in terms of Bessel functions and terms with only Bessel functions. The numerical integration is performed and the graphical results are displayed for the involved flow parameters. It is found that the velocity decreases whereas the shear stress increases when the Hartmann number is increased. The solutions corresponding to the Stokes' first problem for hydrodynamic Burgers' fluids are obtained as limiting cases of the present solutions. Similar solutions for Stokes' second problem of hydrodynamic Burgers' fluids and those for Newtonian and Oldroyd-B fluids can also be obtained as limiting cases of these solutions. PMID:23667442

  1. Determination of Burgers vector of screw dislocations in 6H-SiC single crystals by synchrotron white beam x-ray topography

    Individual screw dislocations along the [0001] axis in 6H-SiC single crystals have been characterized by means of Synchrotron White Beam X-ray Topography (SWBXT). The magnitude of the Burgers vector was determined from: (1) the diameter of circular diffraction-contrast images of dislocations in back-reflection topographs, (2) the width of bi-model images associated with screw dislocations in transmission topographs, (3) the magnitude of the tilt of the lattice planes on both sides of dislocation core in projection topographs, and (4) also the magnitude of the tilt of the lattice planes in section topographs. All of the four methods showed reasonable consistency. The sense of the Burgers vector can also be deduced from the above-mentioned tilt of the lattice planes. Results revealed that in 6H-SiC a variety of screw dislocations can be found with Burgers vector magnitude ranging from 1c to 7c (c is the lattice constant along [0001] axis). This work demonstrates that SWBXT can be used as a quantitative technique for detailed analyses of line defect configurations

  2. Stokes' Second Problem for Magnetohydrodynamics Flow in a Burgers' Fluid: The Cases γ = λ2/4 and γ>λ2/4

    Khan, Ilyas; Ali, Farhad; Shafie, Sharidan

    2013-01-01

    The present work is concerned with exact solutions of Stokes second problem for magnetohydrodynamics (MHD) flow of a Burgers' fluid. The fluid over a flat plate is assumed to be electrically conducting in the presence of a uniform magnetic field applied in outward transverse direction to the flow. The equations governing the flow are modeled and then solved using the Laplace transform technique. The expressions of velocity field and tangential stress are developed when the relaxation time satisfies the condition γ = λ2/4 or γ>λ2/4. The obtained closed form solutions are presented in the form of simple or multiple integrals in terms of Bessel functions and terms with only Bessel functions. The numerical integration is performed and the graphical results are displayed for the involved flow parameters. It is found that the velocity decreases whereas the shear stress increases when the Hartmann number is increased. The solutions corresponding to the Stokes' first problem for hydrodynamic Burgers' fluids are obtained as limiting cases of the present solutions. Similar solutions for Stokes' second problem of hydrodynamic Burgers' fluids and those for Newtonian and Oldroyd-B fluids can also be obtained as limiting cases of these solutions. PMID:23667442

  3. Adhesive contact on power-law graded elastic solids: The JKR-DMT transition using a double-Hertz model

    Jin, Fan; Guo, Xu; Gao, Huajian

    2013-12-01

    A cohesive zone model of axisymmetric adhesive contact between a rigid sphere and a power-law graded elastic half-space is established by extending the double-Hertz model of Greenwood and Johnson (1998). Closed-form solutions are obtained analytically for the surface stress, deformation fields and equilibrium relations among applied load, indentation depth, inner and outer radii of the cohesive zone, which include the corresponding solutions for homogeneous isotropic materials and the Gibson solid as special cases. These solutions provide a continuous transition between JKR and DMT type contact models through a generalized Tabor parameter μ. Our analysis reveals that the magnitude of the pull-off force ranges from (3+k)πRΔγ/2 to 2πRΔγ, where k, R and Δγ denote the gradient exponent of the elastic modulus for the half-space, the radius of the sphere and the work of adhesion, respectively. Interestingly, the pull-off force for the Gibson solid is found to be identically equal to 2πRΔγ, independent of the corresponding Tabor parameter. The obtained analytical solutions are validated with finite element simulations.

  4. Technological aspects of manufacturing and numerical modelling of clinch-adhesive joints

    Sadowski, Tomasz; Golewski, Przemysław

    2015-01-01

    This short book describes the basic technological aspects involved in the creation of purely clinch and clinch-adhesive joints made of different types of adherent materials and employing different joining technologies. Basic parameters that need to be taken into account in the design process are also presented, while a comparison of experimental testing of the hybrid joint with simple clinching for a combination of different joining materials underlines the advantages of opting for hybrid joints. The book’s conclusions will facilitate the practical application of this new fastening technology.

  5. Effect of grilling and baking on physicochemical and textural properties of tilapia (Oreochromis niloticus) fish burger.

    Bainy, Eduarda Molardi; Bertan, Larissa Canhadas; Corazza, Marcos Lucio; Lenzi, Marcelo Kaminski

    2015-08-01

    The influence of two common cooking methods, grilling and baking, on chemical composition, water retention, fat retention, cooking yield, diameter reduction, expressible water, color and mechanical texture of tilapia (Oreochromis niloticus) fish burgers was investigated. Texture analyses were performed using a Warner-Bratzler test. The fish burger had a softer texture with a lower shear force than other meat products reported in the literature. There were no significant differences in proximate composition, diameter reduction, fat retention and expressible water between the grilled and oven-baked fish burgers. Cooking methods did not affect the cooking times and cooking rates. Warner-Bratzler parameters and color were significantly influenced by the cooking method. Grilling contributed to a shear force and work of shearing increase due to the lower cooking yield and water retention. Raw burgers had the highest L* (69.13 ± 0.96) and lowest b* (17.50 ± 0.75) values. Results indicated that baking yielded a product with better cooking characteristics, such as a desired softer texture with lower shear values (4.01 ± 0.54) and increased water retention (95.82 ± 0.77). Additionally, the baked fish burgers were lighter (higher L*) and less red (lower a*) than the grilled ones. PMID:26243932

  6. The inviscid Burgers equation with initial data of Brownian type

    She, Zhen-Su; Aurell, Erik; Frisch, Uriel

    1992-09-01

    The solutions to Burgers equation, in the limit of vanishing viscosity, are investigated when the initial velocity is a Brownian motion (or fractional Brownian motion) function, i.e. a Gaussian process with scaling exponent 0< h<1 (type A) or the derivative thereof, with scaling exponent -1< h<0 (type B). Largesize numerical experiments are performed, helped by the fact that the solution is essentially obtained by performing a Legendre transform. The main result is obtained for type A and concerns the Lagrangian function x(a) which gives the location at time t=1 of the fluid particle which started at the location a. It is found to be a complete Devil's staircase. The cumulative probability of Lagrangian shock intervals Δ a (also the distribution of shock amplitudes) follows a ( Δa)- h law for small Δ a. The remaining (regular) Lagrangian locations form a Cantor set of dimension h. In Eulerian coordinates, the shock locations are everywhere dense. The scaling properties of various statistical quantities are also found. Heuristic interpretations are provided for some of these results. Rigorous results for the case of Brownian motion are established in a companion paper by Ya. Sinai. For type B initial velocities (e.g. white noise), there are very few small shocks and shock locations appear to be isolated. Finally, it is shown that there are universality classes of random but smooth (non-scaling) initial velocities such that the long-time large-scale behavior is, after rescaling, the same as for type A or B.

  7. West Nile virus-induced cell adhesion molecules on human brain microvascular endothelial cells regulate leukocyte adhesion and modulate permeability of the in vitro blood-brain barrier model.

    Kelsey Roe

    Full Text Available Characterizing the mechanisms by which West Nile virus (WNV causes blood-brain barrier (BBB disruption, leukocyte infiltration into the brain and neuroinflammation is important to understand the pathogenesis of WNV encephalitis. Here, we examined the role of endothelial cell adhesion molecules (CAMs in mediating the adhesion and transendothelial migration of leukocytes across human brain microvascular endothelial cells (HBMVE. Infection with WNV (NY99 strain significantly induced ICAM-1, VCAM-1, and E-selectin in human endothelial cells and infected mice brain, although the levels of their ligands on leukocytes (VLA-4, LFA-1and MAC-1 did not alter. The permeability of the in vitro BBB model increased dramatically following the transmigration of monocytes and lymphocytes across the models infected with WNV, which was reversed in the presence of a cocktail of blocking antibodies against ICAM-1, VCAM-1, and E-selectin. Further, WNV infection of HBMVE significantly increased leukocyte adhesion to the HBMVE monolayer and transmigration across the infected BBB model. The blockade of these CAMs reduced the adhesion and transmigration of leukocytes across the infected BBB model. Further, comparison of infection with highly neuroinvasive NY99 and non-lethal (Eg101 strain of WNV demonstrated similar level of virus replication and fold-increase of CAMs in HBMVE cells suggesting that the non-neuropathogenic response of Eg101 is not because of its inability to infect HBMVE cells. Collectively, these results suggest that increased expression of specific CAMs is a pathological event associated with WNV infection and may contribute to leukocyte infiltration and BBB disruption in vivo. Our data further implicate that strategies to block CAMs to reduce BBB disruption may limit neuroinflammation and virus-CNS entry via 'Trojan horse' route, and improve WNV disease outcome.

  8. Efficacy of vitamin E and selenium for the prevention of intra-abdominal adhesions in rats: uterine horn models

    Ali Said Durmus

    2011-01-01

    Full Text Available OBJECTIVE: This study compares the efficacies of vitamin E and selenium, both individually and in combination, for the prevention of postoperative intra-abdominal adhesions in rats. METHODS: Forty-seven female rats were divided into five groups. The sham animals (S group, n = 7 were given only laparotomies and intraperitoneally received 0.9% NaCl (2 ml. In the 40 other rats, abrasions of the left uterine horn were performed, followed by intraperitoneal administration of either 2 ml 0.9% NaCl (C group, 10 mg vitamin E (vitamin E group, 0.2 mg/kg selenium (Se group or 10 mg vitamin E with 0.2 mg/kg selenium (vitamin E + Se group, with 10 animals in each treatment group. RESULTS: Adhesion formation was significantly reduced in animals in the Se and vitamin E + Se groups (p<0.05. Tissue catalase and glutathione peroxidase activities did not significantly differ between the groups. However, catalase and glutathione peroxidase activities and reduced glutathione levels were slightly increased in the vitamin E, Se and vitamin E + Se groups. In the vitamin E group, malondialdehyde concentrations were significantly lower than in the C group (p<0.05, but no significant differences were present among the S, C, Se and vitamin E + Se groups. Levels of nitric oxide were significantly higher in the C group than in the other groups (p<0.01. CONCLUSION: Intraperitoneal administration of selenium or combined vitamin E and selenium appears to be effective in preventing intra-abdominal adhesion formation in rat models through the reduction of lipid peroxidation products.

  9. Bacterial Adhesion & Blocking Bacterial Adhesion

    Vejborg, Rebecca Munk

    2008-01-01

    parameters, which influence the transition from a planktonic lifestyle to a sessile lifestyle, have been studied. Protein conditioning film formation was found to influence bacterial adhesion and subsequent biofilm formation considerable, and an aqueous extract of fish muscle tissue was shown to...... tract to the microbial flocs in waste water treatment facilities. Microbial biofilms may however also cause a wide range of industrial and medical problems, and have been implicated in a wide range of persistent infectious diseases, including implantassociated microbial infections. Bacterial adhesion is...... the first committing step in biofilm formation, and has therefore been intensely scrutinized. Much however, still remains elusive. Bacterial adhesion is a highly complex process, which is influenced by a variety of factors. In this thesis, a range of physico-chemical, molecular and environmental...

  10. Existence and uniqueness of entropy solution to initial boundary value problem for the inviscid Burgers equation

    Zhu, C

    2003-01-01

    This paper is concerned with the existence and uniqueness of the entropy solution to the initial boundary value problem for the inviscid Burgers equation. To apply the method of vanishing viscosity to study the existence of the entropy solution, we first introduce the initial boundary value problem for the viscous Burgers equation, and as in Evans (1998 Partial Differential Equations (Providence, RI: American Mathematical Society) and Hopf (1950 Commun. Pure Appl. Math. 3 201-30), give the formula of the corresponding viscosity solutions by Hopf-Cole transformation. Secondly, we prove the convergence of the viscosity solution sequences and verify that the limiting function is an entropy solution. Finally, we give an example to show how our main result can be applied to solve the initial boundary value problem for the Burgers equation.

  11. Existence and uniqueness of entropy solution to initial boundary value problem for the inviscid Burgers equation

    This paper is concerned with the existence and uniqueness of the entropy solution to the initial boundary value problem for the inviscid Burgers equation. To apply the method of vanishing viscosity to study the existence of the entropy solution, we first introduce the initial boundary value problem for the viscous Burgers equation, and as in Evans (1998 Partial Differential Equations (Providence, RI: American Mathematical Society) and Hopf (1950 Commun. Pure Appl. Math. 3 201-30), give the formula of the corresponding viscosity solutions by Hopf-Cole transformation. Secondly, we prove the convergence of the viscosity solution sequences and verify that the limiting function is an entropy solution. Finally, we give an example to show how our main result can be applied to solve the initial boundary value problem for the Burgers equation

  12. Existence and uniqueness of entropy solution to initial boundary value problem for the inviscid Burgers equation

    Zhu, Changjiang; Duan, Renjun [Laboratory of Nonlinear Analysis, Department of Mathematics, Central China Normal University, Wuhan 430079, People' s Republic of China (China)

    2003-02-28

    This paper is concerned with the existence and uniqueness of the entropy solution to the initial boundary value problem for the inviscid Burgers equation. To apply the method of vanishing viscosity to study the existence of the entropy solution, we first introduce the initial boundary value problem for the viscous Burgers equation, and as in Evans (1998 Partial Differential Equations (Providence, RI: American Mathematical Society) and Hopf (1950 Commun. Pure Appl. Math. 3 201-30), give the formula of the corresponding viscosity solutions by Hopf-Cole transformation. Secondly, we prove the convergence of the viscosity solution sequences and verify that the limiting function is an entropy solution. Finally, we give an example to show how our main result can be applied to solve the initial boundary value problem for the Burgers equation.

  13. Accurate Solutions of the Plasma Motion Equation May be Composed with the Accurate Solutions of the Burgers Equation

    Weng Jianping

    2005-01-01

    The travelling solutions of the Burgers equation may be used as the seed solutions.According to the fraction-type deforming relation between the Burgers equation and the plasma motion equation, some travelling solutions of the plasma motion equation are achieved with this seed solutions as discussed in this paper.

  14. The Legacy of the Burger Court and the Schools, 1969-1986. NOLPE Monograph/Book Series No. 41.

    Vacca, Richard S.; Hudgins, H. C., Jr.

    This book is limited to a study of the education opinions of the Supreme Court during the time that Warren Earl Burger served as Chief Justice. Over 100 opinions having direct bearing on education were issued during the Burger years, a total greater than in the entire Court's history. The first chapter presents the history of the establishment of…

  15. Effects of Rhodomyrtus tomentosa Leaf Extract on Staphylococcal Adhesion and Invasion in Bovine Udder Epidermal Tissue Model

    Mordmuang, Auemphon; Shankar, Shiv; Chethanond, Usa; Voravuthikunchai, Supayang Piyawan

    2015-01-01

    Bovine mastitis is one of the most important infectious diseases in dairy herds, and staphylococci are the most important etiologic agents of this disease. Antibiotics and chemical agents used in livestock for prevention and cure of the disease can accumulate in milk and give rise to food safety concerns. Rhodomyrtus tomentosa leaf extract was studied as an alternative approach to reduce the bacterial infections. The ethanolic extract of this plant demonstrated antibacterial activity with minimum inhibitory concentration (MIC) values as low as 16–64 μg/mL against staphylococcal isolates. In addition, the extract had an effect on the bacterial cell surface properties by increasing its hydrophobicity in a concentration dependent manner. To further extend the antibacterial efficacy, silver nanoparticles synthesized with the extract, a pure rhodomyrtone, and liposomal encapsulated rhodomyrtone were applied and their inhibitory effects on bacterial adhesion and invasion were determined by ex vivo study in a bovine udder epidermal tissue model. These agents exerted remarkable antibacterial activity against staphylococci and decreased the adhesion of the bacterial cells to the tissues. These results supported that R. tomentosa ethanolic extract could be applied as an alternative agent for bovine udder care in dairy farms. PMID:26501314

  16. On the MHD flow of fractional generalized Burgers' fluid with modified Darcy's law

    T. Hayat; M. Khan; S. Asghar

    2007-01-01

    This work is concerned with applying the fractional calculus approach to the magnetohydrodynamic(MHD) pipe flow of a fractional generalized Burgers' fluid in a porous space by using modified Darcy's relationship. The fluid is electrically conducting in the presence of a constant applied magnetic field in the transverse direction. Exact solution for the velocity distribution is developed with the help of Fourier transform for fractional calculus. The solutions for a Navier-Stokes, second grade, Maxwell, Oldroyd-B and Burgers' fluids appear as the limiting cases of the present analysis.

  17. The Statistics of Burgers Turbulence Initialized with Fractional Brownian Noise Data

    Ryan, Reade

    The statistics of the solution to the inviscid Burgers equation are investigated when the initial velocity potential is fractional Brownian motion. Using the theory of large deviations for Gaussian processes, we characterize the tails of the probability distribution functions (PDFs) of the velocity, the distance between shocks, and the shock strength. These PDFs are shown to decay like ``stretched'' exponentials of the form . Our method of proof can also be used to extend these results to a much larger class of Gaussian potentials. This work generalizes the results of Avellaneda and E [2, 3] on the inviscid Burgers equation with white-noise initial data.

  18. A spectral domain decomposition approach for the generalized Burger's-Fisher equation

    In this study, we use the spectral collocation method using Chebyshev polynomials for spatial derivatives and fourth order Runge-Kutta method for time integration to solve the generalized Burger's-Fisher equation (B-F). Firstly, theory of application of Chebyshev spectral collocation method (CSCM) and domain decomposition on the generalized Burger's-Fisher equation is presented. This method yields a system of ordinary differential algebraic equations (DAEs). Secondly, we use fourth order Runge-Kutta formula for the numerical integration of the system of DAEs. The numerical results obtained by this way have been compared with the exact solution to show the efficiency of the method

  19. The Cauchy problem for the (generalized) Kadomtsev-Petviashvili-Burgers equation

    Molinet, Luc

    2000-01-01

    We investigate the Cauchy problem for the generalized Kadomtsev-Petviashvili-Burgers (KP-Burgers) equation in Sobolev spaces. This nonlinear wave equation has both dispersive and dissipative parts which makes it quite particular. After showing local existence by contraction principle for initial data $ \\varphi\\in H^s(\\mathbb R^2) $ such that $ {\\mathcal F}^{-1} (\\frac{k_2}{k_1} \\widehat{\\varphi})\\in H^r(\\mathbb R^2) $, $ 0{\\leqslant} r {\\leqslant} s- 1 $, we try to extend the s...

  20. Note on the single-shock solutions of the Korteweg-de Vries-Burgers equation

    Kourakis, Ioannis; Verheest, Frank

    2011-01-01

    The well-known shock solutions of the Korteweg-de Vries-Burgers equation are revisited, together with their limitations in the context of plasma (astro)physical applications. Although available in the literature for a long time, it seems to have been forgotten in recent papers that such shocks are monotonic and unique, for a given plasma configuration, and cannot show oscillatory or bell-shaped features. This uniqueness is contrasted to solitary wave solutions of the two parent equations (Korteweg-de Vries and Burgers), which form a family of curves parameterized by the excess velocity over the linear phase speed.

  1. Exact Solutions for the (2+1)-Dimensional Nonlinear Modified Korteweg-de Vries-Burger Equation in Shallow Water

    In this work, we have investigated the solitary and shock waves solutions for the two-dimensional modified KdV-Burger (MKdV-B) equation that combines the effects of both dispersion and nonlinearity in shallow water model. The methods of energy integral approach and modified extended Tanh-function have been applied on the ordinary differential equation of the non dimensional MKdV-B equation to obtain the exact soliton solutions. We also found the dispersion relation of the linear non dimensional MKdV-B equation, which used to find the phase and group velocities; the relations between them are discussed. The results studied analytically and indicated in graphics

  2. Electrically Conductive Epoxy Adhesives

    Lan Bai

    2011-02-01

    Full Text Available Conductive adhesives are widely used in electronic packaging applications such as die attachment and solderless interconnections, component repair, display interconnections, and heat dissipation. The effects of film thickness as functions of filler volume fraction, conductive filler size, shape, as well as uncured adhesive matrix viscosity on the electrical conduction behavior of epoxy-based adhesives are presented in this work. For this purpose, epoxy-based adhesives were prepared using conductive fillers of different size, shape, and types, including Ni powder, flakes, and filaments, Ag powder, and Cu powder. The filaments were 20 μm in diameter, and 160 or 260 μm in length. HCl and H3PO4 acid solutions were used to etch and remove the surface oxide layers from the fillers. The plane resistance of filled adhesive films was measured using the four-point method. In all cases of conductive filler addition, the planar resistivity levels for the composite adhesive films increased when the film thickness was reduced. The shape of resistivity-thickness curves was negative exponential decaying type and was modeled using a mathematical relation. The relationships between the conductive film resistivities and the filler volume fractions were also derived mathematically based on the experimental data. Thus, the effects of surface treatment of filler particles, the type, size, shape of fillers, and the uncured epoxy viscosity could be included empirically by using these mathematical relations based on the experimental data. By utilizing the relations we proposed to model thickness-dependent and volume fraction-dependent conduction behaviors separately, we were able to describe the combined and coupled volume fraction-film thickness relationship mathematically based on our experimental data.

  3. Variable Separation Solutions for the (2+1)-Dimensional Burgers Equation

    唐晓艳; 楼森岳

    2003-01-01

    Considering that the multi-linear variable separation approach has been proved to be very useful to solve many (2+1)-dimensional integrable systems, we obtain the variable separation solutions of the Burgers equation with arbitrary number of variable separated functions. The Y-shaped soliton fusion phenomenon is revealed.

  4. Bifractality of the Devil's staircase appearing in the Burgers equation with Brownian initial velocity

    Aurell, E; Noullez, A; Blank, M

    1996-01-01

    It is shown that the inverse Lagrangian map for the solution of the Burgers equation (in the inviscid limit) with Brownian initial velocity presents a bifractality (phase transition) similar to that of the Devil's staircase for the standard triadic Cantor set. Both heuristic and rigorous derivations are given. It is explained why artifacts can easily mask this phenomenon in numerical simulations.

  5. Stochastic heat and Burgers equations and their singularities II - Analytical Properties and Limiting Distributions

    Davies, I M; Zhao, H

    2004-01-01

    We study the inviscid limit, $\\mu\\to 0$, of the stochastic viscous Burgers equation, for the velocity field $v^{\\mu}(x,t)$, $t>0$, $x\\in\\mathbb R^d$,\\frac{\\partial{v^{\\mu}}}{\\partial{t}} + (v^{\\mu}\\cdot\

  6. Exponential ergodicity for stochastic Burgers and 2D Navier-Stokes equations

    Goldys, B.; Maslowski, Bohdan

    2005-01-01

    Roč. 226, č. 1 (2005), s. 230-255. ISSN 0022-1236 R&D Projects: GA ČR(CZ) GA201/04/0750 Institutional research plan: CEZ:AV0Z10190503 Keywords : exponential ergodicity * v-uniform ergodicity * stochastic Burgers equation Subject RIV: BA - General Mathematics Impact factor: 0.806, year: 2005

  7. EXISTENCE OF WEAK SOLUTIONS FOR A DEGENERATE GENERALIZED BURGERS EQUATION WITH LARGE INITIAL DATA

    张辉

    2002-01-01

    It is obtained the existence of the weak solution for a degenerate generalized Burgers equation under the restriction u0 ∈ L∞. The main method is to add viscosity perturbation and obtain some estimates in L1 norm. Meanwhile it is obtained the solution is exponential decay when the initial data has compact support.

  8. A New Method to Construct Integrable Coupling System for Burgers Equation Hierarchy by Kronecker Product

    It is shown that the Kronecker product can be applied to construct a new integrable coupling system of soliton equation hierarchy in this paper. A direct application to the Burgers spectral problem leads to a novel soliton equation hierarchy of integrable coupling system. It indicates that the Kronecker product is an efficient and straightforward method to construct the integrable couplings.

  9. A control problem for Burgers' equation with bounded input/output

    Burns, John A.; Kang, Sungkwon

    1990-01-01

    A stabilization problem for Burgers' equation is considered. Using linearization, various controllers are constructed which minimize certain weighted energy functionals. These controllers produce the desired degree of stability for the closed-loop nonlinear system. A numerical scheme for computing the feedback gain functional is developed and several numerical experiments are performed to show the theoretical results.

  10. On the well-posedness for Kadomtsev-Petviashvili-Burgers I equation

    Darwich, Mohamad

    We prove local and global well-posedness in H(R2), s>-1/2 >, for the Cauchy problem associated with the Kadomtsev-Petviashvili-Burgers I equation (KPBI) by working in Bourgain's type spaces. This result is almost sharp if one requires the flow-map to be smooth.

  11. On the well-posedness for Kadomtsev-Petviashvili-Burgers I equation

    Darwich, Mohamad

    2011-01-01

    We prove local and global well-posedness in $H^{s,0}(\\mathbb{R}^{2})$, $s > -1/2$, for the Cauchy problem associated with the Kadomotsev-Petviashvili-Burgers-I equation (KPBI) by working in Bourgain's type spaces. This result is almost sharp if one requires the flow-map to be smooth.

  12. On the well-posedness for Kadomtsev-Petviashvili-Burgers I equation.

    Darwich, Mohamad

    2012-01-01

    We prove local and global well-posedness in $H^{s,0}(\\mathbb{R}^{2})$, $s > -\\frac{1}{2}$, for the Cauchy problem associated with the Kadomotsev-Petviashvili-Burgers-I equation (KPBI) by working in Bourgain's type spaces. This result is almost sharp if one requires the flow-map to be smooth.

  13. A unified approach to an augmented Burgers equation for the propagation of sonic booms.

    Yamamoto, Masafumi; Hashimoto, Atsushi; Aoyama, Takashi; Sakai, Takeharu

    2015-04-01

    Nonlinear propagation through a relaxing atmosphere of pressure disturbances extracted from a computational fluid dynamics (CFD) solution of the flow around a supersonic aircraft is simulated using an augmented Burgers equation. The effects of nonlinearity, geometrical spreading, atmospheric inhomogeneity, thermoviscous attenuation, and molecular vibration relaxation are taken into account. The augmented Burgers equation used for sonic boom propagation calculations is often solved by the operator splitting method, but numerical difficulties arise with this approach when dissipation is not effective. By re-examining the solution algorithms for the augmented Burgers equation, a stable method for handling the relaxation effect has been developed. This approach can handle the Burgers equation in a unified manner without operator splitting and, therefore, the resulting scheme is twice as fast as the original one. The approach is validated by comparing it with an analytical solution and a detailed CFD of dispersed plane wave propagation. In addition, a rise time prediction of low-boom supersonic aircraft is demonstrated. PMID:25920838

  14. Large Time Behaviour of Solutions of a System of Generalized Burgers Equation

    K T Joseph

    2005-11-01

    In this paper we study the asymptotic behaviour of solutions of a system of partial differential equations. When = 1 the equation reduces to the Burgers equation and was studied by Hopf. We consider both the inviscid and viscous case and show a new feature in the asymptotic behaviour.

  15. Okara, a soymilk industry by-product, as a non-meat protein source in reduced fat beef burgers

    Simone Ing Tie Su

    2013-02-01

    Full Text Available Okara is a by-product generated during the manufacture of soymilk and tofu. Wet okara was added to beef burgers at 0%, 20%, and 25%. The effects of okara on certain physicochemical, textural, and sensory properties of reduced fat beef burgers were investigated. The beef burgers formulated with okara (104.0-106.0 kcal/100 g had 60% less calories than commercial beef burgers (268.8 kcal/100 g. The texture profile analysis showed that the addition of wet okara led to a significant increase in hardness (p < 0.05 and a concomitant reduction in the values of chewiness, springiness, and cohesiveness. Lower sensory scores (p < 0.05 of flavour were observed in the beef burgers containing 25% wet okara. However, the sensory evaluation results showed that juiciness, appearance, tenderness, and overall acceptability of beef burgers formulated with okara did not differ statistically from that of the control (0% okara. Wet okara (20% can be used as a non-meat protein source in the production of reduced-fat beef burgers without changing their sensory quality.

  16. Effect of Temperature-Sensitive Poloxamer Solution/Gel Material on Pericardial Adhesion Prevention: Supine Rabbit Model Study Mimicking Cardiac Surgery.

    Hyun Kang

    Full Text Available We investigated the mobility of a temperature-sensitive poloxamer/Alginate/CaCl2 mixture (PACM in relation to gravity and cardiac motion and the efficacy of PACM on the prevention of pericardial adhesion in a supine rabbit model.A total of 50 rabbits were randomly divided into two groups according to materials applied after epicardial abrasion: PACM and dye mixture (group PD; n = 25 and saline as the control group (group CO; n = 25. In group PD, rabbits were maintained in a supine position with appropriate sedation, and location of mixture of PACM and dye was assessed by CT scan at the immediate postoperative period and 12 hours after surgery. The grade of adhesions was evaluated macroscopically and microscopically two weeks after surgery.In group PD, enhancement was localized in the anterior pericardial space, where PACM and dye mixture was applied, on immediate post-surgical CT scans. However, the volume of the enhancement was significantly decreased at the anterior pericardial space 12 hours later (P < .001. Two weeks after surgery, group PD had significantly lower macroscopic adhesion score (P = .002 and fibrosis score (P = .018 than did group CO. Inflammation score and expression of anti-macrophage antibody in group PD were lower than those in group CO, although the differences were not significant.In a supine rabbit model study, the anti-adhesion effect was maintained at the area of PACM application, although PACM shifted with gravity and heart motion. For more potent pericardial adhesion prevention, further research and development on the maintenance of anti-adhesion material position are required.

  17. Analysis of a Burgers equation with singular resonant source term and convergence of well-balanced schemes [Well-posedness of a singular balance law

    Andreianov, Boris; Seguin, Nicolas

    2012-01-01

    We define entropy weak solutions and establish well-posedness for the Cauchy problem for the formal equation $$\\partial_t u(t,x) + \\partial_x \\frac{u^2}2(t,x) = - \\lambda u(t,x) \\delta_0(x),$$ which can be seen as two Burgers equations coupled in a non-conservative way through the interface located at $x=0$. This problem appears as an important auxiliary step in the theoretical and numerical study of the one-dimensional particle-in-fluid model developed by Lagoutière, Seguin and Takahashi [LS...

  18. Adhesion and Cohesion

    J. Anthony von Fraunhofer

    2012-01-01

    Full Text Available The phenomena of adhesion and cohesion are reviewed and discussed with particular reference to dentistry. This review considers the forces involved in cohesion and adhesion together with the mechanisms of adhesion and the underlying molecular processes involved in bonding of dissimilar materials. The forces involved in surface tension, surface wetting, chemical adhesion, dispersive adhesion, diffusive adhesion, and mechanical adhesion are reviewed in detail and examples relevant to adhesive dentistry and bonding are given. Substrate surface chemistry and its influence on adhesion, together with the properties of adhesive materials, are evaluated. The underlying mechanisms involved in adhesion failure are covered. The relevance of the adhesion zone and its importance with regard to adhesive dentistry and bonding to enamel and dentin is discussed.

  19. In vitro model of bone to facilitate measurement of adhesion forces and super-resolution imaging of osteoclasts.

    Deguchi, Takahiro; Alanne, Maria H; Fazeli, Elnaz; Fagerlund, Katja M; Pennanen, Paula; Lehenkari, Petri; Hänninen, Pekka E; Peltonen, Juha; Näreoja, Tuomas

    2016-01-01

    To elucidate processes in the osteoclastic bone resorption, visualise resorption and related actin reorganisation, a combination of imaging technologies and an applicable in vitro model is needed. Nanosized bone powder from matching species is deposited on any biocompatible surface in order to form a thin, translucent, smooth and elastic representation of injured bone. Osteoclasts cultured on the layer expressed matching morphology to ones cultured on sawed cortical bone slices. Resorption pits were easily identified by reflectance microscopy. The coating allowed actin structures on the bone interface to be visualised with super-resolution microscopy along with a detailed interlinked actin networks and actin branching in conjunction with V-ATPase, dynamin and Arp2/3 at actin patches. Furthermore, we measured the timescale of an adaptive osteoclast adhesion to bone by force spectroscopy experiments on live osteoclasts with bone-coated AFM cantilevers. Utilising the in vitro model and the advanced imaging technologies we localised immunofluorescence signals in respect to bone with high precision and detected resorption at its early stages. Put together, our data supports a cyclic model for resorption in human osteoclasts. PMID:26935172

  20. Adhesion and multi-materials

    Adhesion is a multidisciplinary science relevant to many practical fields. The main application of adhesion is bonding by adhesives. This technique is widely used in the industrial world and more specifically in the advanced technical domains. Adhesion is also involved in multi-component materials such as coatings, multilayer materials, polymer blends, composite materials... The multidisciplinary aspect of adhesion is well demonstrated by considering the wide variety of concepts, models and theories proposed for its description. An example of the adhesion between a fiber and a matrix in a composite material will lead to a general model relating the molecular properties of the interface to its capacity of stress transfer and hence to the macroscopic mechanical properties of the composite. This relationship is valid whatever the fiber (glass, carbon, polymeric) or the polymer matrix (thermoplastics, thermosetting). Any deviation from this model can be attributed to the existence of an interfacial zone or interphase exhibiting properties, mainly mechanical properties, different from the bulk matrix. Two examples are examined: the first one deals with the creation of a trans crystalline interphase in a semi-crystalline thermoplastic matrix and the second one is concerned with the formation of a pseudo glassy interphase in an elastomer matrix. These examples stress the need for complementary approaches in the understanding of adhesion phenomena at different levels of knowledge, from molecular to macroscopic. They also show how important it is to understand the mechanisms of formation of inter phases in order to be able to master the performance of multicomponent materials. (Author)

  1. Improving the physico-chemical and sensory characteristics of camel meat burger patties using ginger extract and papain.

    Abdel-Naeem, Heba H S; Mohamed, Hussein M H

    2016-08-01

    The objective of the current study was to include tenderizing agents in the formulation of camel meat burger patties to improve the physico-chemical and sensory characteristics of the product. Camel meat burger patties were processed with addition of ginger extract (7%), papain (0.01%) and mixture of ginger extract (5%) and papain (0.005%) in addition to control. Addition of ginger, papain and their mixture resulted in significant (Ppapain extract caused noticeable destructive effect on connective tissue. Moreover, ginger and papain resulted in improvement of the lipid stability of treated burger patties during storage. Therefore, addition of ginger extract and papain powder during formulation of camel burger patties can improve their physico-chemical and sensory properties. PMID:27045253

  2. Integrable Hierarchy Covering the Lattice Burgers Equation in Fluid Mechanics: N-fold Darboux Transformation and Conservation Laws

    Burgers-type equations can describe some phenomena in fluids, plasmas, gas dynamics, traffic, etc. In this paper, an integrable hierarchy covering the lattice Burgers equation is derived from a discrete spectral problem. N-fold Darboux transformation (DT) and conservation laws for the lattice Burgers equation are constructed based on its Lax pair. N-soliton solutions in the form of Vandermonde-like determinant are derived via the resulting DT with symbolic computation, structures of which are shown graphically. Coexistence of the elastic-inelastic interaction among the three solitons is firstly reported for the lattice Burgers equation, even if the similar phenomenon for certern continuous systems is known. Results in this paper might be helpful for understanding some ecological problems describing the evolution of competing species and the propagation of nonlinear waves in fluids.

  3. Integrable Hierarchy Covering the Lattice Burgers Equation in Fluid Mechanics: N-fold Darboux Transformation and Conservation Laws

    闻小永; 高以天; 薛玉山; 郭睿; 齐风华; 丁鑫

    2012-01-01

    Burgers-type equations can describe some phenomena in fluids, plasmas, gas dynamics, traffic, etc. In this paper, an integrable hierarchy covering the lattice Burgers equation is derived from a discrete spectral problem. N-fold Darboux transformation (DT) and conservation laws for the lattice Burgers equation are constructed based on its Lax pair. N-soliton solutions in the form of Vandermonde-like determinant are derived via the resulting DT with symbolic computation, structures of which are shown graphically. Coexistence of the elastic-inelastic interaction among the three solitons is firstly reported for the lattice Burgers equation, even if the similar phenomenon for certern continuous systems is known. Results in this paper might be helpful for understanding some ecological problems describing the evolution of competing species and the propagation of nonlinear waves in fluids.

  4. Power and power-logarithmic expansions for travelling-wave solutions of the Burgers-Huxley equation

    Efimova, Olga Yu.; Kudryashov, Nikolai A.; Chmykhov, Mikhail A.

    2005-01-01

    The Burgers-Huxley equation is studied. All power and power-logarithmic expansions for travelling-wave solutions of this equation are presented. Using the power expansions, some exact solutions of this equation are found.

  5. Host Selection of Microbiota via Differential Adhesion.

    McLoughlin, Kirstie; Schluter, Jonas; Rakoff-Nahoum, Seth; Smith, Adrian L; Foster, Kevin R

    2016-04-13

    The host epithelium is the critical interface with microbial communities, but the mechanisms by which the host regulates these communities are poorly understood. Here we develop the hypothesis that hosts use differential adhesion to select for and against particular members of their microbiota. We use an established computational, individual-based model to study the impact of host factors that regulate adhesion at the epithelial surface. Our simulations predict that host-mediated adhesion can increase the competitive advantage of microbes and create ecological refugia for slow-growing species. We show how positive selection via adhesion can be transformed into negative selection if the host secretes large quantities of a matrix such as mucus. Our work predicts that adhesion is a powerful mechanism for both positive and negative selection within the microbiota. We discuss molecules-mucus glycans and IgA-that affect microbe adhesion and identify testable predictions of the adhesion-as-selection model. PMID:27053168

  6. Theoretical modeling of the catch-slip bond transition in biological adhesion

    Gunnerson, Kim; Pereverzev, Yuriy; Prezhdo, Oleg

    2006-05-01

    The mechanism by which leukocytes leave the blood stream and enter inflamed tissue is called extravasation. This process is facilitated by the ability of selectin proteins, produced by the endothelial cells of blood vessels, to form transient bonds with the leukocytes. In the case of P-selectin, the protein bonds with P-selectin glycoprotein ligands (PSGL-1) produced by the leukocyte. Recent atomic force microscopy and flow chamber analyses of the binding of P-selectin to PSGL-1 provide evidence for an unusual biphasic catch-bond/slip-bond behavior in response to the strength of exerted force. This biphasic process is not well-understood. There are several theoretical models for describing this phenomenon. These models use different profiles for potential energy landscapes and how they change under forces. We are exploring these changes using molecular dynamics. We will present a simple theoretical model as well as share some of our early MD results for describing this phenomenon.

  7. Restoration of non-carious cervical lesions with ceramic inlays: A possible model for clinical testing of adhesive cements

    Michal Staninec; Tsuji, Grant H.

    2012-01-01

    Introduction: There are many luting cements coming to market which claim to be adhesive, but there is no clinical protocol currently for testing these claims. There is a standardized protocol for testing direct restorations bonded to dentin and it is used extensively. Case Report: We describe a clinical procedure for restoring a non-carious cervical lesion (NCCL) with a ceramic inlay using Computer-Aided Design and Computer-Aided Manufacturing (CAD-CAM) technology and an adhesive resin cement...

  8. Analysis of stress-induced Burgers vector anisotropy in pressurized tube specimens of irradiated ferritic-martensitic steel: JLF-1

    Gelles, D.S. [Pacific Northwest National Lab., Richland, WA (United States); Shibayama, T. [Univ. of Hokkaido, Oarai, Ibaraki (Japan). Inst. for Materials Research

    1998-09-01

    A procedure for determining the Burgers vector anisotropy in irradiated ferritic steels allowing identification of all a<100> and all a/2<111> dislocations in a region of interest is applied to a pressurized tube specimen of JLF-1 irradiated at 430 C to 14.3 {times} 10{sup 22} n/cm{sup 2} (E > 0.1 MeV) or 61 dpa. Analysis of micrographs indicates large anisotropy in Burgers vector populations develop during irradiation creep.

  9. Analytical model of asymmetrical Mixed-Mode Bending test of adhesively bonded GFRP joint

    Ševčík, Martin; Hutař, Pavel; Vassilopoulos, Anastasios P.; Shahverdi, M.

    2015-01-01

    Roč. 9, č. 34 (2015), s. 237-246. ISSN 1971-8993 R&D Projects: GA MŠk(CZ) EE2.3.30.0063; GA ČR GA15-09347S Institutional support: RVO:68081723 Keywords : GFRP materials * Mixed-Mode bending * Fiber bridging * Analytical model Subject RIV: JL - Materials Fatigue, Friction Mechanics

  10. Colloid chemistry: available sorption models and the question of colloid adhesion

    A safety analysis of a radioactive waste repository should consider the possibility of nuclide transport by colloids. This would involve describing the sorption properties of the colloids and their transport in porous and fissured media. This report deals with a few selected aspects of the chemistry of this complex subject. Because the mechanisms of ion adsorption onto surfaces are material-specific, increased attention should be paid to identifying the material constitution of aquatic colloids. Suitable models already exist for describing reversible adsorption; these models describe sorption using mass action equations. The surface coordination model, developed for hydrous oxide surfaces, allows a uniform approach to be adopted for different classes of materials. This model is also predictive and has been applied successfully to natural systems. From the point of view of nuclide transport by colloids, irreversible sorption represents the most unfavourable situation. There is virtually no information available on the extent of reversibility and on the desorption kinetics of important nuclide/colloid combinations. Experimental investigations are therefore necessary in this respect. The only question considered in connection with colloid transport and its modelling is that of colloid sticking. Natural colloids, and the surfaces of the rock on which they may be collected, generally have negative surface charges so that colloid sticking will be difficult. The DLVO theory contains an approach for calculating the sticking factor from the surface potentials of the solid phases and the ionic strength of the water. However, it has been shown that this theory is inapplicable because of inherent shortcomings which lead to completely unrealistic predictions. The sticking probability of colloids should therefore be determined experimentally for systems which correspond as closely as possible to reality. (author) 66 figs., 12 tabs., 204 refs

  11. USING OF COMBINED TREATMENT BETWEEN PROPOLIS (BEE GLUE) AND GAMMA RADIATION FOR EXTENDING SHELF-LIFE OF CHICKEN BURGER

    This investigation was carried out to extend the shelf-life of chicken burger using ethanol extract of propolis (EEP) at different concentrations (1 and 2%) as individual treatment using gamma irradiation at doses of 1.5, 3 and 4.5 kGy as individual treatment and combined treatments. The untreated and treated samples of chicken burger were divided into three groups, the first was control, the second group was chicken burger samples treated with 1% EEP then irradiated at doses of 1.5, 3 and 4.5 kGy and the third group was chicken burger samples treated with 2 % EEP then irradiated at doses of 1.5, 3 and 4.5 kGy. The effects of these treatments on the microbiological, chemical and sensory characteristics of chicken burger samples were studied post-treatment and during cold storage (4±10C). The results showed that concentrations of EEP at 1 and 2% reduced the total bacterial count, lactic acid bacteria, Enterobacteriaceae total mold and yeast count, Staphylococcus aureus, Enterococccus faecalis and Bacillus cereus, and the growth of Salmonella spp, was not detected in all treated samples. Also, shelf-life periods were increased up to 27 days for chicken burger treated by 2% EEP and gamma radiation at dose of 4.5 kGy and these combined treatment were more effective as antimicrobial, consequently may be useful as natural food preservative

  12. Symmetries and invariant solutions of the two-dimensional variable coefficient Burgers equation

    We discuss symmetries and reductions of the two-dimensional Burgers equation with variable coefficient. We classify one-dimensional and two-dimensional subalgebras of the Burgers symmetry algebra which is infinite-dimensional into conjugacy classes under the adjoint action of the symmetry group. Invariance under one-dimensional subalgebras provides reductions to lower-dimensional partial differential equations. Further reductions of these equations to second order ordinary differential equations are obtained through invariance under two-dimensional subalgebras. The reduced ODEs are then analysed and shown that they belong to the polynomial class of second-order equations which can be linearized only for particular values of parameters figuring in the coefficient. (author)

  13. The tyger phenomenon for the Galerkin-truncated Burgers and Euler equations

    Ray, Samriddhi Sankar; Nazarenko, Sergei; Matsumoto, Takeshi

    2010-01-01

    It is shown that the solutions of inviscid hydrodynamical equations with suppression of all spatial Fourier modes having wavenumbers in excess of a threshold $\\kg$ exhibit unexpected features. The study is carried out for both the one-dimensional Burgers equation and the two-dimensional incompressible Euler equation. At large $\\kg$, for smooth initial conditions, the first symptom of truncation, a localized short-wavelength oscillation which we call a "tyger", is caused by a resonant interaction between fluid particle motion and truncation waves generated by small-scale features (shocks, layers with strong vorticity gradients, etc). These tygers appear when complex-space singularities come within one Galerkin wavelength $\\lambdag = 2\\pi/\\kg$ from the real domain and typically arise far away from preexisting small-scale structures at locations whose velocities match that of such structures. Tygers are weak and strongly localized at first - in the Burgers case at the time of appearance of the first shock their ...

  14. Adhesion to Primary and Permanent Dentin and a Simple Model Approach

    Can-Karabulut, Deniz C.; Oz, Firdevs Tulga; Karabulut, Baris; Batmaz, Inci; Ilk, Ozlem

    2009-01-01

    Objectives First to compare different dentin bonding agents’ shear bond strength to primary and permanent dentin. Secondly to compare the fracture failure modes and making an attempt to develop a statistical model that could be helpful in predicting them. Methods Extracted human primary and permanent molars were used as substrates (dentin). The shear bond strength of composite to substrate was measured and fracture surfaces were evaluated visually and with stereomicroscope. Using the data obt...

  15. Multicomponent adhesive hard sphere models and short-ranged attractive interactions in colloidal or micellar solutions

    Gazzillo, Domenico; Giacometti, Achille; Fantoni, Riccardo; Sollich, Peter

    2006-11-01

    We investigate the dependence of the stickiness parameters tij=1/(12τij) —where the τij are the conventional Baxter parameters—on the solute diameters σi and σj in multicomponent sticky hard sphere (SHS) models for fluid mixtures of mesoscopic neutral particles. A variety of simple but realistic interaction potentials, utilized in the literature to model short-ranged attractions present in real solutions of colloids or reverse micelles, is reviewed. We consider: (i) van der Waals attractions, (ii) hard-sphere-depletion forces, (iii) polymer-coated colloids, and (iv) solvation effects (in particular hydrophobic bonding and attractions between reverse micelles of water-in-oil microemulsions). We map each of these potentials onto an equivalent SHS model by requiring the equality of the second virial coefficients. The main finding is that, for most of the potentials considered, the size-dependence of tij(T,σi,σj) can be approximated by essentially the same expression, i.e., a simple polynomial in the variable σiσj/σij2 , with coefficients depending on the temperature T , or—for depletion interactions—on the packing fraction η0 of the depletant particles.

  16. Using plukenetia volubilis (sacha inchi) to improve the nutritional components of burger

    Daniela Baldeón Clavijo; Francisco Velásquez Rodríguez; Jesús Eligio Castellanos Estupiñán

    2015-01-01

    (Received: 2015/03/18 - Accepted: 2015/05/27)Three levels of paste Plukenetia volubilis (Sacha Inchi) consisting of 10, 15% and 20% were evaluated to replace the weight percent lard conventionally used to improve the nutritional quality of the common hamburger, compared with a reference group. The experimental units were 10 burgers, weighing 100 g. each and a total of 120 were analyzed in a completely randomized design with three replications. The research was conducted in the Universidad Est...

  17. Anomalous scaling in the random-force-driven Burgers equation. A Monte Carlo study

    Mesterhazy, D. [Technische Univ. Darmstadt (Germany). Inst. fuer Kernphysik; Jansen, K. [Deutsches Elektronen-Synchrotron (DESY), Zeuthen (Germany)

    2011-07-15

    We present a new approach to determine numerically the statistical behavior of small-scale structures in hydrodynamic turbulence. Starting from the functional integral for the random-force-driven Burgers equation we show that Monte Carlo simulations allow for the computation of structure function scaling exponents to high precision. Given the general applicability of Monte Carlo methods, this opens up the possibility to address also other systems relevant to turbulence within this framework. (orig.)

  18. Anomalous scaling in the random-force-driven Burgers equation. A Monte Carlo study

    Mesterhazy, David [TU Darmstadt (Germany). Inst. fuer Kernphysik; Jansen, Karl [Deutsches Elektronen-Synchrotron (DESY), Zeuthen (Germany). John von Neumann Inst. fuer Computing

    2011-12-15

    We present a new approach to determine the small-scale statistical behavior of hydrodynamic turbulence by means of lattice simulations. Using the functional integral representation of the random-force-driven Burgers equation we show that high-order moments of velocity differences satisfy anomalous scaling. The general applicability of Monte Carlo methods provides the opportunity to study also other systems of interest within this framework. (orig.)

  19. Energy dissipation and resolution of steep gradients in one-dimensional Burgers flows

    Tran, Chuong V

    2009-01-01

    Travelling-wave solutions of the inviscid Burgers equation having smooth initial wave profiles of suitable shapes are known to develop shocks (infinite gradients) in finite times. Such singular solutions are characterized by energy spectra that scale with the wave number $k$ as $k^{-2}$. **** In this study, we carry out an analysis which verifies the dynamical features described above and derive upper bounds for $\\epsilon$ and $N$. It is found that $\\epsilon$ satisfies $\\epsilon \\le \

  20. Hausdorff dimension of regular points in stochastic Burgers flows with Levy α-stable initial data

    This paper studies statistical properties of shocks for the inviscid Burgers equation with an α-stable Levy motion initial data. In the absence of analytic results, numerical and computer simulation tools are utilized. Qualitative and quantitative information on the scaling properties of Lagrangian regular points of solutions is obtained and, in particular, their Hausdorff dimension is estimated to be 1/α. This suggests a possible extension of Ya. Sinai's result for Brownian initial data

  1. Burgers-like equation for spontaneous breakdown of the chiral symmetry in QCD

    Blaizot, Jean-Paul; Nowak, Maciej A.; Warchoł, Piotr

    2013-01-01

    We link the spontaneous breakdown of chiral symmetry in Euclidean QCD to the collision of spectral shock waves in the vicinity of zero eigenvalue of Dirac operator. The mechanism, originating from complex Burger's-like equation for viscid, pressureless, one-dimensional flow of eigenvalues, is similar to recently observed weak-strong coupling phase transition in large $N_c$ Yang-Mills theory. The spectral viscosity is proportional to the inverse of the size of the random matrix that replaces t...

  2. Approximate Damped Oscillatory Solutions for Generalized KdV-Burgers Equation and Their Error Estimates

    Weiguo Zhang; Xiang Li

    2011-01-01

    We focus on studying approximate solutions of damped oscillatory solutions of generalized KdV-Burgers equation and their error estimates. The theory of planar dynamical systems is employed to make qualitative analysis to the dynamical systems which traveling wave solutions of this equation correspond to. We investigate the relations between the behaviors of bounded traveling wave solutions and dissipation coefficient, and give two critical values λ1 and λ2 which can characte...

  3. Determining the Burgers vectors and elastic strain energies of interface dislocation arrays using anisotropic elasticity theory

    Vattre, Aurelien J.; Demkowicz, Michael J.

    2013-01-01

    A formalism for describing interface dislocation arrays linking the Frank–Bilby equation and anisotropic elasticity theory under the condition of vanishing far-field stresses is developed. The present approach enables the determination of a unique reference state for interface misfit dislocations, within which the Burgers vectors of individual dislocations are defined and allows for the unequal partitioning of elastic fields between neighboring crystals. The elastic strain energies of interfa...

  4. Exact solutions of KdV-Burgers' equation by Exp-function method

    This paper applies the Exp-function method to obtain generalized solitary solutions and periodic solutions for nonlinear evolution equations arising in mathematical physics with the aid of symbolic computation method. The Korteweg-de Vries-Burgers (KdVB) equation is used as an example to illustrate the effectiveness of this method. The solution process is straightforward and concise, and its applications is promising for other nonlinear evolution equations.

  5. Analysis of the self-similar solutions of a generalized Burger's equation with nonlinear damping

    Rao Ch. Srinivasa

    2001-01-01

    Full Text Available The nonlinear ordinary differential equation resulting from the self-similar reduction of a generalized Burgers equation with nonlinear damping is studied in some detail. Assuming initial conditions at the origin we observe a wide variety of solutions – (positive single hump, unbounded or those with a finite zero. The existence and nonexistence of positive bounded solutions with different types of decay (exponential or algebraic to zero at infinity for specific parameter ranges are proved.

  6. The Upwind Finite Volume Element Method for Two-Dimensional Burgers Equation

    Qing Yang

    2013-01-01

    A finite volume element method for approximating the solution to two-dimensional Burgers equation is presented. Upwind technique is applied to handle the nonlinear convection term. We present the semi-discrete scheme and fully discrete scheme, respectively. We show that the schemes are convergent to order one in space in ${L}^{\\mathrm{2}}$ -norm. Numerical experiment is presented finally to validate the theoretical analysis.

  7. A Constitutive Model for Uni-axial Compaction of Non-adhesive Corn Stalk Powder

    Zhao Dong; Sun Yanling

    2004-01-01

    In order to study mechanical behaviors of corn stalk powder during the compaction, the yield criterion for corn stalk powder is proposed with a plasticity theory. From the stress-strain curves of uni-axial compaction test for corn stalk powder, the constitutive model, in which the equations are modified by experiments on corn stalk powder, is adopted to describe plastic behaviors of powder, and is discussed based on the incremental theory and deformation theory. The numerical results agree well with the experimental ones.

  8. Impact of essential oils on the taste acceptance of tomato juice, vegetable soup, or poultry burgers.

    Espina, Laura; García-Gonzalo, Diego; Pagán, Rafael

    2014-08-01

    Despite the vast body of available literature on the possibilities of essential oils (EOs) as food preservatives or functional ingredients, the sensory impact of their addition to foods has barely been approached. This work focuses on the hedonic taste acceptance of 3 food products (tomato juice, vegetable soup, and poultry burgers) when they are incorporated with potentially antimicrobial concentrations (20 to 200 μL/L) of 6 selected EOs (lemon, pennyroyal mint, thyme, and rosemary) and individual compounds (carvacrol, p-cymene). Although addition of 20 μL/L of pennyroyal mint or lemon EO did not change the taste acceptance of tomato juice, higher concentrations of these compounds or any concentration of the other 4 compounds did. In vegetable soup, the tolerance limit for rosemary EO, thyme EO, carvacrol, or p-cymene was 20 μL/L, while the addition of 200 μL/L of lemon EO was accepted. Tolerance limits in poultry burgers were established in 20 μL/L for carvacrol and thyme EOs, 100 μL/L for pennyroyal mint EO and p-cymene, and 200 μL/L for lemon and rosemary EOs. Moreover, incorporation of pennyroyal mint EO to tomato juice or poultry burgers, and enrichment of vegetable soup with lemon EO, could contribute to the development of food products with an improved sensory appeal. PMID:25077550

  9. My 2030s. Citizens about the Biobased Economy; My 2030s. Burgers over de Biobased Economy

    Van den Berg, N.; Hulshof, M.; Van der Veen, M.

    2013-02-15

    My 2030s is the first qualitative study of the needs and concerns of citizens about the Biobased Economy, an economy in which fossil fuels are largely substituted by vegetable alternatives. This final report describes the reason and purpose of My 2030s, the course of the public debates and the results of research into ideas of citizens on the Biobased Economy The report concludes with recommendations on how the stakeholders can actively involve citizens in one of the major transitions of the next century [Dutch] My 2030s is het eerste kwalitatieve onderzoek naar de wensen en zorgen van burgers over de Biobased Economy, een economie waarin fossiele grondstoffen grotendeels zijn vervangen door plantaardige alternatieven. Dit eindrapport beschrijft de aanleiding en opzet van My 2030s, het verloop van de publieksdebatten en de resultaten van het onderzoek naar denkbeelden van burgers over de Biobased Economy. Het rapport eindigt met aanbevelingen over hoe de stakeholders burgers actief kunnen betrekken bij een van de belangrijkste transities van de komende eeuw.

  10. Approximate Damped Oscillatory Solutions for Compound KdV-Burgers Equation and Their Error Estimates

    Wei-guo ZHANG; Yan ZHAO; Xiao-yan TENG

    2012-01-01

    In this paper,we focus on studying approximate solutions of damped oscillatory solutions of the compound KdV-Burgers equation and their error estimates.We employ the theory of planar dynamical systems to study traveling wave solutions of the compound KdV-Burgers equation.We obtain some global phase portraits under different parameter conditions as well as the existence of bounded traveling wave solutions.Furthermore,we investigate the relations between the behavior of bounded traveling wave solutions and the dissipation coefficient r of the equation.We obtain two critical values of r,and find that a bounded traveling wave appears as a kink profile solitary wave if |r| is greater than or equal to some critical value,while it appears as a damped oscillatory wave if |r| is less than some critical value.By means of analysis and the undetermined coefficients method,we find that the compound KdV-Burgers equation only has three kinds of bell profile solitary wave solutions without dissipation.Based on the above discussions and according to the evolution relations of orbits in the global phase portraits,we obtain all approximate damped oscillatory solutions by using the undetermined coefficients method.Finally,using the homogenization principle,we establish the integral equations reflecting the relations between exact solutions and approximate solutions of damped oscillatory solutions.Moreover,we also give the error estimates for these approximate solutions.

  11. On the multivariate Burgers equation and the incompressible Navier-Stokes equation

    Kampen, Joerg

    2009-01-01

    We prove global existence of the multivariate viscous Burgers equation system defined on the whole space or on a domain isomorphic to the $n$-torus and with time horizon up to infinity and $C^{\\infty}$- data (satisfying some growth conditions if the problem is posed on the whole space). The proof is by a semi-explicit perturbative expansion in transformed coordinates where the convergence is guaranteed by certain a priori estimates. Under some moderate conditions uniqueness of the global solution of the multivariate Burgers equation is a consequence of uniqueness of solutions of a semilinear system. The global solution ${\\bf u}$ constructed is H\\"older continuous and serves to define coefficients of a system which is linear in terms of ${\\bf u}$. The fundamental solution of the latter system is called the fundamental functional and is dependent on the initial data of the Burgers problem in a generic way. The fundamental functional proves useful in order to construct solutions for a class of semilinear partial...

  12. Bacterial adhesion and biofilms on surfaces

    Trevor Roger Garrett; Manmohan Bhakoo; Zhibing Zhang

    2008-01-01

    Bacterial adhesion has become a significant problem in industry and in the domicile,and much research has been done for deeper understanding of the processes involved.A generic biological model of bacterial adhesion and population growth called the bacterial biofilm growth cycle,has been described and modified many times.The biofilm growth cycle encompasses bacterial adhesion at all levels,starting with the initial physical attraction of bacteria to a substrate,and ending with the eventual liberation of cell dusters from the biofilm matrix.When describing bacterial adhesion one is simply describing one or more stages of biofilm development,neglecting the fact that the population may not reach maturity.This article provides an overview of bacterial adhesion.cites examples of how bac-terial adhesion affects industry and summarises methods and instrumentation used to improve our understanding of the adhesive prop-erties of bacteria.

  13. Prolonged Morphine Exposure Induces Increased Firm Adhesion in an in Vitro Model of the Blood-Brain Barrier.

    Strazza, Marianne; Pirrone, Vanessa; Wigdahl, Brian; Dampier, Will; Lin, Wei; Feng, Rui; Maubert, Monique E; Weksler, Babette; Romero, Ignacio A; Couraud, Pierre-Olivier; Nonnemacher, Michael R

    2016-01-01

    The blood-brain barrier (BBB) has been defined as a critically important protective barrier that is involved in providing essential biologic, physiologic, and immunologic separation between the central nervous system (CNS) and the periphery. Insults to the BBB can cause overall barrier damage or deregulation of the careful homeostasis maintained between the periphery and the CNS. These insults can, therefore, yield numerous phenotypes including increased overall permeability, interendothelial gap formation, alterations in cytokine and chemokine secretion, and accelerated cellular passage. The current studies expose the human brain microvascular endothelial cell line, hCMEC/D3, to prolonged morphine exposure and aim to uncover the mechanisms underlying alterations in barrier function in vitro. These studies show alterations in the mRNA and protein levels of the cellular adhesion molecules (CAMs) intercellular adhesion molecule-1, vascular cell adhesion molecule-1, and activated leukocyte cell adhesion molecule that correlate with an increased firm adhesion of the CD3⁺ subpopulation of peripheral blood mononuclear cells (PBMCs). Overall, these studies suggest that prolonged morphine exposure may result in increased cell migration into the CNS, which may accelerate pathological processes in many diseases that involve the BBB. PMID:27294916

  14. Prolonged Morphine Exposure Induces Increased Firm Adhesion in an in Vitro Model of the Blood–Brain Barrier

    Strazza, Marianne; Pirrone, Vanessa; Wigdahl, Brian; Dampier, Will; Lin, Wei; Feng, Rui; Maubert, Monique E.; Weksler, Babette; Romero, Ignacio A.; Couraud, Pierre-Olivier; Nonnemacher, Michael R.

    2016-01-01

    The blood–brain barrier (BBB) has been defined as a critically important protective barrier that is involved in providing essential biologic, physiologic, and immunologic separation between the central nervous system (CNS) and the periphery. Insults to the BBB can cause overall barrier damage or deregulation of the careful homeostasis maintained between the periphery and the CNS. These insults can, therefore, yield numerous phenotypes including increased overall permeability, interendothelial gap formation, alterations in cytokine and chemokine secretion, and accelerated cellular passage. The current studies expose the human brain microvascular endothelial cell line, hCMEC/D3, to prolonged morphine exposure and aim to uncover the mechanisms underlying alterations in barrier function in vitro. These studies show alterations in the mRNA and protein levels of the cellular adhesion molecules (CAMs) intercellular adhesion molecule-1, vascular cell adhesion molecule-1, and activated leukocyte cell adhesion molecule that correlate with an increased firm adhesion of the CD3+ subpopulation of peripheral blood mononuclear cells (PBMCs). Overall, these studies suggest that prolonged morphine exposure may result in increased cell migration into the CNS, which may accelerate pathological processes in many diseases that involve the BBB. PMID:27294916

  15. On the Transition from Bulk to Ordered Form of Water: A Theoretical Model to Calculate Adhesion Force Due to Capillary and van der Waals Interaction

    Yaqoob, M.A.; de, Rooij, R.; Schipper, D.J.

    2013-01-01

    The adhesion force due to capillary interaction between two hydrophilic surfaces is strongly dependent on the partial pressure of water and is often calculated using the Kelvin equation. The validity of the Kelvin equation is questionable at low relative humidity (RH) of water, like in high vacuum and dry nitrogen environments, where water is only present as layers of several molecules thick at the surfaces. A model from ordered to bulk form of water has been developed using the Brunauer, Emm...

  16. Adhesion in microelectronics

    Mittal, K L

    2014-01-01

    This comprehensive book will provide both fundamental and applied aspects of adhesion pertaining to microelectronics in a single and easily accessible source. Among the topics to be covered include; Various theories or mechanisms of adhesionSurface (physical or chemical) characterization of materials as it pertains to adhesionSurface cleaning as it pertains to adhesionWays to improve adhesionUnraveling of interfacial interactions using an array of pertinent techniquesCharacterization of interfaces / interphasesPolymer-polymer adhesionMetal-polymer adhesion  (metallized polymers)Polymer adhesi

  17. Derde evaluatie van de Algemene wet bestuursrecht 2006: Awb-procedures vanuit het gezichtspunt van de burger; stand van zaken in theorie en eerder onderzoek

    Laemers, M.T.A.B.; Groot-van Leeuwen, L.E. de; Fredriks, R.

    2007-01-01

    In de eerste Awb-evaluatie is de werking van de Awb voornamelijk vanuit het perspectief van bestuursorganen en rechters onderzocht. Aangezien de Awb-procedure er onder andere toe dient om problemen tussen belanghebbenden (veelal burgers) en overheidsorganen te beslechten is het perspectief van de burger eveneens van belang. In de tweede evaluatie is op kleine schaal aandacht besteed aan de ervaringen van burgers met Awb-procedures. In dat onderzoek zijn repeat players (personen die – veelal b...

  18. Restoration of non-carious cervical lesions with ceramic inlays: A possible model for clinical testing of adhesive cements

    Michal Staninec

    2012-01-01

    Full Text Available Introduction: There are many luting cements coming to market which claim to be adhesive, but there is no clinical protocol currently for testing these claims. There is a standardized protocol for testing direct restorations bonded to dentin and it is used extensively. Case Report: We describe a clinical procedure for restoring a non-carious cervical lesion (NCCL with a ceramic inlay using Computer-Aided Design and Computer-Aided Manufacturing (CAD-CAM technology and an adhesive resin cement.The procedure was straightforward and the result was good at one month. Discussion: NCCL′s can be restored with CAD-CAM technology in one appointment. This technique can be used to clinically test adhesion of luting cements to dentin, similarly to the current standard for direct restorations.

  19. Mild hypothermia effects on intercellular adhesion molecule-1 and serum interleukin-6 expression in brain tissues of a rat focal ischemia model

    Shengqi Fu; Lei Yang; Shuling Zhang; Shilong Sun; Xingai Mao

    2008-01-01

    BACKGROUND: Previous studies have confirmed the neuroprotective effect of mild hypothermia on ischemic brain injury.OBJECTIVE: To investigate the effects of mild hypothermia on intercellular adhesion molecule-1 expression and serum interleukin-6 levels in ischemic brain tissues of focal brain ischemia rats, and to explore the neuroprotective effects of mild hypothermia on ischemic brain injury.DESIGN, TIME AND SETTING: A randomized, controlled, neurobiological experiment was performed at the Central Laboratory, First Affiliated Hospital, Xinxiang Medical College, China from February to July 2006.MATERIALS: Thirty healthy, adult, Sprague Dawley rats were used to establish middle cerebral artery occlusion models using the suture method. The immunohistochemistry (streptavidin-biotin-peroxidase complex method) kit was purchased from Boster, China. Interleukin-6 radioimmunoassay was supplied by Institute of Radioimmunity, Technology Development Center, General Hospital of Chinese PLA. METHODS: The rats were equally and randomly assigned into mild hypothermia and control groups, and middle cerebral artery occlusion models were established. The rectal temperature was maintained at (37 ± 0.5)℃ in the control group. In the mild hypothermia group, the rectal temperature was maintained at (33±1)℃.MAIN OUTCOME MEASURES: At 12 hours after model establishment, the ischemic brain hemispheres were coronally sliced at the level of the optic chiasm. The number of intercellular adhesion molecule- 1 -positive vessels per high-power field was observed with an optical microscope. Serum interleukin-6 levels were measured by radioimmunoassay.RESULTS: Compared with the control group, intercellular adhesion molecule-I and serum interleukin-6 expressions were significantly decreased in ischemic brain tissues of the mild hypothermia group (P < 0.01).CONCLUSION: Mild hypothermia exhibits a neuroprotective effect by reducing serum interleukin-6 and intercellular adhesion molecule- 1

  20. Thermal Characterization of Adhesive

    Spomer, Ken A.

    1999-01-01

    The current Space Shuttle Reusable Solid Rocket Motor (RSRM) nozzle adhesive bond system is being replaced due to obsolescence. Down-selection and performance testing of the structural adhesives resulted in the selection of two candidate replacement adhesives, Resin Technology Group's Tiga 321 and 3M's EC2615XLW. This paper describes rocket motor testing of these two adhesives. Four forty-pound charge motors were fabricated in configurations that would allow side by side comparison testing of the candidate replacement adhesives and the current RSRM adhesives. The motors provided an environment where the thermal performance of adhesives in flame surface bondlines was compared. Results of the FPC testing show that: 1) The phenolic char depths on radial bond lines is approximately the same and vary depending on the position in the blast tube regardless of which adhesive was used; 2) The adhesive char depth of the candidate replacement adhesives is less than the char depth of the current adhesives; 3) The heat-affected depth of the candidate replacement adhesives is less than the heat-affected depth of the current adhesives; and 4) The ablation rates for both replacement adhesives are slower than that of the current adhesives.

  1. Transcriptional analysis of genes associated with stress and adhesion in Lactobacillus acidophilus NCFM during the passage through an in vitro gastrointestial tract model

    Weiss, Gudrun Margarethe; Jespersen, Lene

    2010-01-01

    The aim of the present study was to investigate the transcription of genes associated with stress and adhesion in Lactobacillus acidophilus NCFM during the passage through an in vitro gastrointestinal tract model. As acidified milk exerted a protective effect on the bacteria leading to increased...... survival, the gene expression studies were carried out with pre-inoculation of L. acidophilus NCFM in acidified milk. The induction of the genes encoding the stress-related proteins GroEL, DnaK and ClpP, and adhesion-related genes encoding mucin-binding proteins, fibronectin-binding protein and S-layer was...... juice, but they were significantly upregulated during incubation in duodenal juice and bile (6- to 7-fold). A significant induction of the gene encoding the S-layer protein was not detected. Our results give a better understanding of the functionality of L. acidophilus NCFM and other probiotics during...

  2. Design and fabrication of polymer based dry adhesives inspired by the gecko adhesive system

    Jin, Kejia

    There has been significant interest in developing dry adhesives mimicking the gecko adhesive system, which offers several advantages compared to conventional pressure sensitive adhesives. Specifically, gecko adhesive pads have anisotropic adhesion properties: the adhesive pads (spatulae) stick strongly when sheared in one direction but are non-adherent when sheared in the opposite direction. This anisotropy property is attributed to the complex topography of the array of fine tilted and curved columnar structures (setae) that bear the spatulae. In this thesis, easy, scalable methods, relying on conventional and unconventional techniques are presented to incorporate tilt in the fabrication of synthetic polymer-based dry adhesives mimicking the gecko adhesive system, which provide anisotropic adhesion properties. In the first part of the study, the anisotropic adhesion and friction properties of samples with various tilt angles to test the validity of a nanoscale tape-peeling model of spatular function are measured. Consistent with the Peel Zone model, samples with lower tilt angles yielded larger adhesion forces. Contact mechanics of the synthetic array were highly anisotropic, consistent with the frictional adhesion model and gecko-like. Based on the original design, a new design of gecko-like dry adhesives was developed which showed superior tribological properties and furthermore showed anisotropic adhesive properties without the need for tilt in the structures. These adhesives can be used to reversibly suspend weights from vertical surfaces (e.g., walls) and, for the first time to our knowledge, horizontal surfaces (e.g., ceilings) by simultaneously and judiciously activating anisotropic friction and adhesion forces. Furthermore, adhesion properties between artificial gecko-inspired dry adhesives and rough substrates with varying roughness are studied. The results suggest that both adhesion and friction forces on a rough substrate depends significantly on the

  3. Understanding Marine Mussel Adhesion

    H. G. Silverman; F. F. Roberto

    2007-12-01

    In addition to identifying the proteins that have a role in underwater adhesion by marine mussels, research efforts have focused on identifying the genes responsible for the adhesive proteins, environmental factors that may influence protein production, and strategies for producing natural adhesives similar to the native mussel adhesive proteins. The production-scale availability of recombinant mussel adhesive proteins will enable researchers to formulate adhesives that are waterimpervious and ecologically safe and can bind materials ranging from glass, plastics, metals, and wood to materials, such as bone or teeth, biological organisms, and other chemicals or molecules. Unfortunately, as of yet scientists have been unable to duplicate the processes that marine mussels use to create adhesive structures. This study provides a background on adhesive proteins identified in the blue mussel, Mytilus edulis, and introduces our research interests and discusses the future for continued research related to mussel adhesion.

  4. Understanding marine mussel adhesion.

    Silverman, Heather G; Roberto, Francisco F

    2007-01-01

    In addition to identifying the proteins that have a role in underwater adhesion by marine mussels, research efforts have focused on identifying the genes responsible for the adhesive proteins, environmental factors that may influence protein production, and strategies for producing natural adhesives similar to the native mussel adhesive proteins. The production-scale availability of recombinant mussel adhesive proteins will enable researchers to formulate adhesives that are water-impervious and ecologically safe and can bind materials ranging from glass, plastics, metals, and wood to materials, such as bone or teeth, biological organisms, and other chemicals or molecules. Unfortunately, as of yet scientists have been unable to duplicate the processes that marine mussels use to create adhesive structures. This study provides a background on adhesive proteins identified in the blue mussel, Mytilus edulis, and introduces our research interests and discusses the future for continued research related to mussel adhesion. PMID:17990038

  5. Adhesion mechanism of a gecko-inspired oblique structure with an adhesive tip for asymmetric detachment

    Sekiguchi, Yu; Takahashi, Kunio; Sato, Chiaki

    2015-12-01

    An adhesion model of an oblique structure with an adhesive tip is proposed by considering a limiting stress for adhesion to describe the detachment mechanism of gecko foot hairs. When a force is applied to the root of the oblique structure, normal and shear stresses are generated at contact and the adhesive tip is detached from the surface when reaching the limiting stress. An adhesion criterion that considers both the normal and shear stresses is introduced, and the asymmetric detachment of the oblique structure is theoretically investigated. In addition, oblique beam array structures are manufactured, and an inclination effect of the structure on the asymmetric detachment is experimentally verified.

  6. Dynamic analysis of two adhesively bonded rods

    Kenneth L. Kuttler

    2009-07-01

    Full Text Available This work presents two models for the dynamic analysis of two rods that are adhesively bonded. The first model assumes that the adhesive is an elasto-plastic material and that complete debonding occurs when the stress reaches the yield limit. In the second model the degradation of the adhesive is described by the introduction of material damage. Failure occurs when the material is completely damaged, or the damage reaches a critical floor value. Both models are analyzed and the existence of a weak solution is established for the model with damage. In the quasistatic case, a new condition for adhesion is found as the limit of the adhesive thickness tends to zero.

  7. Adhesion of Cercaria (Larva of Helminth Parasites to Host by Lectins- Carbohydrates Bonds as a Model for Evaluation of Schistosoma Entrance Mechanisms in Cercarial Dermatitis

    A Farahnak

    2008-07-01

    Full Text Available Background: Cercariae (larva of helminth parasites are covered by a thick glycocalyx coat, which serves as an osmotic protection during their free existence, and contain carbohydrates conjugated as glycoproteins, glycolipids and mucopolysaccharides. Although, limited studies have been made on life cycle of cercariae from fresh water snails, however, carbohydrate studies on cercariae have not been done in Iran so far. This study was made to determine the cercariae specifications from Lymnaea gedrosiana and evaluation of surface carbohydrates as receptors for host lectins in a host-parasite relationship system as a model in human schistosomiasis including cercarial dermatitis in Khuzestan Province. Methods: For this purpose, snails were collected from Dezful region in Khuzestan Province and cercariae were obtained by shedding method and identified by valuable keys. Experimental infection was established in the Culex pipiens (Culicidae mosquitoes larvae for further identification and mode of adhesion. To detect the mode of adhesion, surface carbohydrates of cercariae were detected by lentil (Lens culinaris lectins. Results: Examined snails were infected with xiphidiocerceria of trematodes and metacercariae were obtained from Culex pipiens. Also, Mannose monosaccharides- CH2OH (CHOH 4CHO - were detected particularly on the glands of cercariae. Conclusion: Adhesion of cercariae to their host by lectins-carbohydrates bonds is the first stage of host-parasite relationship. This phenomenon could be happened for animal schistosome's cercaria in cercarial dermatitis.

  8. Abdominal Adhesions

    ... campuses in Maryland and Arizona Research Resources Protocols, repositories, mouse models, plasmids, and more Technology Advancement & Transfer ... through its clearinghouses and education programs to increase knowledge and understanding about health and disease among patients, ...

  9. Impact of Nisin-Activated Packaging on Microbiota of Beef Burgers during Storage

    Ferrocino, Ilario; Greppi, Anna; La Storia, Antonietta; Rantsiou, Kalliopi; Ercolini, Danilo

    2015-01-01

    Beef burgers were stored at 4°C in a vacuum in nisin-activated antimicrobial packaging. Microbial ecology analyses were performed on samples collected between days 0 and 21 of storage to discover the population diversity. Two batches were analyzed using RNA-based denaturing gradient gel electrophoresis (DGGE) and pyrosequencing. The active packaging retarded the growth of the total viable bacteria and lactic acid bacteria. Culture-independent analysis by pyrosequencing of RNA extracted directly from meat showed that Photobacterium phosphoreum, Lactococcus piscium, Lactobacillus sakei, and Leuconostoc carnosum were the major operational taxonomic units (OTUs) shared between control and treated samples. Beta diversity analysis of the 16S rRNA sequence data and RNA-DGGE showed a clear separation between two batches based on the microbiota. Control samples from batch B showed a significant high abundance of some taxa sensitive to nisin, such as Kocuria rhizophila, Staphylococcus xylosus, Leuconostoc carnosum, and Carnobacterium divergens, compared to control samples from batch A. However, only from batch B was it possible to find a significant difference between controls and treated samples during storage due to the active packaging. Predicted metagenomes confirmed differences between the two batches and indicated that the use of nisin-based antimicrobial packaging can determine a reduction in the abundance of specific metabolic pathways related to spoilage. The present study aimed to assess the viable bacterial communities in beef burgers stored in nisin-based antimicrobial packaging, and it highlights the efficacy of this strategy to prolong beef burger shelf life. PMID:26546424

  10. Investigation of detonation propagation through an array of random discrete energy sources using the reactive Burgers' analog

    di Labbio, Giuseppe; Kiyanda, Charles Basenga; Mi, Xiaocheng; Higgins, Andrew Jason; Nikiforakis, Nikolaos; Ng, Hoi Dick

    2015-11-01

    For a homogeneous reactive medium such as a combustible gaseous mixture, the detonation wave is nearly always observed to propagate at a velocity predicted by the Chapman-Jouguet (CJ) condition. Although the CJ condition was originally formulated for a wave propagating in homogeneous media at constant velocity, it has been posited that this condition may also determine the average detonation velocity in heterogeneous media. This work aims to test the applicability of the CJ condition to heterogeneous media on the one-dimensional reactive Burgers' equation, a tractable analog to the reactive Euler equations, with the reaction governed by an Arrhenius rate law. In this study, heterogeneity is modeled using discrete energy sources, of random energy content, randomly distributed throughout space such that the total energy release is equivalent to that of a homogeneous medium with constant energy density. The equations are solved using a second-order finite volume approach with an exact Riemann solver. The evolution of the discrete detonation is tracked over a long duration and its average propagation velocity is computed. In all cases, the average detonation velocity was found to be in agreement with the velocity predicted by the CJ condition for the equivalent homogeneous system.

  11. Critical length scale controls adhesive wear mechanisms

    Aghababaei, Ramin; Warner, Derek H.; Molinari, Jean-Francois

    2016-06-01

    The adhesive wear process remains one of the least understood areas of mechanics. While it has long been established that adhesive wear is a direct result of contacting surface asperities, an agreed upon understanding of how contacting asperities lead to wear debris particle has remained elusive. This has restricted adhesive wear prediction to empirical models with limited transferability. Here we show that discrepant observations and predictions of two distinct adhesive wear mechanisms can be reconciled into a unified framework. Using atomistic simulations with model interatomic potentials, we reveal a transition in the asperity wear mechanism when contact junctions fall below a critical length scale. A simple analytic model is formulated to predict the transition in both the simulation results and experiments. This new understanding may help expand use of computer modelling to explore adhesive wear processes and to advance physics-based wear laws without empirical coefficients.

  12. Exact Solutions for an MHD Generalized Burgers fluid: Stokes' Second Problem

    Khan, Masood; Anjum, Asia

    2013-01-01

    This paper offers the exact analytical solutions for the magnetohydrodynamic (MHD) flow of an incompressible generalized Burgers fluid corresponding to the second problem of Stokes in the presence of the transverse magnetic field. Modified Darcy's law has been taken into account. The expression for the velocity field and associated tangential stress, presented as a sum of the steady-state and transient solutions, are obtained by means of the integral transforms. Moreover, several figures are plotted to investigate the effects of various emerging parameters on the velocity field. The obtained results show that the magnitude of the velocity and boundary layer thickness significantly reduce in the presence of magnetic field.

  13. Integrability, analyticity, isochrony, equilibria, small oscillations, and Diophantine relations: results from the stationary Burgers hierarchy

    Bruschi, M; Calogero, F [Dipartimento di Fisica, Universita di Roma ' La Sapienza' , 00185 Roma (Italy); Droghei, R [Dipartimento di Fisica, Universita Roma Tre (Italy)], E-mail: mario.bruschi@roma1.infn.it, E-mail: francesco.calogero@roma1.infn.it, E-mail: francesco.calogero@uniroma1.it, E-mail: droghei@fis.uniroma3.it

    2009-11-27

    An isochronous system is introduced by modifying the Nth ODE of the stationary Burgers hierarchy, and then, by investigating its behaviour near its equilibria, neat Diophantine relations are identified, involving (well-known) polynomials of arbitrary degree having integer zeros, or equivalently matrices the determinants of which yield such polynomials. The basic idea to arrive at such relations is not new, but the specific application reported in this paper is new, and it is likely to open the way to several analogous new findings.

  14. Nonequivalent Similarity Reductions and Exact Solutions for Coupled Burgers-Type Equations

    Using the machinery of Lie group analysis, the nonlinear system of coupled Burgers-type equations is studied. Using the infinitesimal generators in the optimal system of subalgebra of the said Lie algebras, it leads to two nonequivalent similarity transformations by using it we obtain two reductions in the form of system of nonlinear ordinary differential equations. The search for solutions of these systems by using the G'/G-method has yielded certain exact solutions expressed by rational functions, hyperbolic functions, and trigonometric functions. Some figures are given to show the properties of the solutions. (general)

  15. 2D Zakharov-Kuznetsov-Burgers equations with variable dissipation on a strip

    Nikolai A. Larkin

    2015-03-01

    Full Text Available An initial-boundary value problem for a 2D Zakharov-Kuznetsov-Burgers type equation with dissipation located in a neighborhood of $x=-\\infty$ and posed on a channel-type strip was considered. The existence and uniqueness results for regular and weak solutions in weighted spaces as well as exponential decay of small solutions without restrictions on the width of a strip were proven both for regular solutions in an elevated norm and for weak solutions in the $L^2$-norm.

  16. Solitary wave and periodic wave solutions for variants of the KdV-Burger and the K(n, n-Burger equations by the generalized tanh-coth method

    Jalil Manafian Heris

    2013-08-01

    Full Text Available An application of the generalized tanh-coth method to search for exact solutions of nonlinear partial differential equations is analyzed. This method is used for variants of the KdV-Burger and the K(n, n-Burger equations. The generalized tanh-coth method was used to construct periodic wave and solitary wave solutions of nonlinear evolution equations. This method is developed for searching exact travelling wave solutions of nonlinear partial differential equations. It is shown that the generalized tanh-coth method, with the help of symbolic computation, provides a straightforward and powerful mathematical tool for solving nonlinear problems.

  17. A physical model to describe the distribution of adhesion strength in MEMS, or why one MEMS device sticks and another ‘identical’ one does not

    In this paper a model is presented that describes the distribution of adhesion values typically experimentally observed for different MEMS devices that have been fabricated in the same way. This spread is attributed to the fact that different devices differ in the details of their surface roughness, even if these surface roughnesses are modeled as coming from the same ‘parent’ stochastic process. Using Monte Carlo simulations, the effect of surface roughness and relative humidity has been evaluated in detail, both on the expected mean value of the surface interaction energy between the MEMS surfaces, and the expected spread on this value from device to device. By comparing the new model to existing literature reporting this experimentally observed spread, we have found excellent agreement between the experimental spread observed, and the spread calculated with the theoretical model using Monte Carlo simulations. This work paves the way to detailed adhesion failure predictive modeling. It may be used to assess the reliability of MEMS designs that rely on contacting surfaces for their operation, but have a limited restoring force available to separate the surfaces when in contact. (paper)

  18. Juiciness improvement of frozen battered shrimp burger using modified tapioca starch, sodium alginate, and iota-carrageenan

    Kongkarn Kijroongrojana

    2009-11-01

    Full Text Available A battered shrimp burger, as a new value-added shrimp product, was developed by increasing the juiciness of a frozen battered shrimp burger using a mixture of hydrocolloids. The formulations of hydrocolloid mixtures containing modified tapioca starch (MTS, sodium alginate (AL, and iota-carrageenan (CA were optimized. Juiciness measurements were defined and analyzed by 13 trained panelists. Texture Profile Analysis (TPA as well as moisture and fat contents of the products were analyzed. The mixture of MTS and AL had an impact on moisture content and juiciness scores, while CA influenced the hardness. The product made using the optimized formulation (0.3% MTS + 0.7% AL had a higher moisture content andjuiciness scores (p0.05. However, higher springiness and gumminess were found in the control burger (p0.05.

  19. Adhesion of endometrial cells labeled with 111 Indium-tropolonate to peritoneum: a novel in vitro model to study endometriosis

    Beliard, Aude; Noël, Agnès; Goffin, Frédéric; Frankenne, Francis; Foidart, Jean-Michel

    2003-01-01

    Objective: To evaluate, in a new original in vitro assay, putative factors that could modulate the adhesion of endometrial cells to peritoneum. Design: Prospective, controlled in vitro study. Setting: Academic research laboratory. Patient(s): Fourteen nonmenopausal women undergoing hysterectomy or laparoscopy for benign gynecologic indication. Intervention(s): Endometrial cells obtained from women with regular cycles without endometriosis were labeled with (111)Indium and confronted in vitro ...

  20. An occludin-focal adhesion kinase protein complex at the blood-testis barrier: a study using the cadmium model.

    Siu, Erica R; Wong, Elissa W P; Mruk, Dolores D; Sze, K L; Porto, Catarina S; Cheng, C Yan

    2009-07-01

    Several integral membrane proteins that constitute the blood-testis barrier (BTB) in mammalian testes, in particular rodents, are known to date. These include tight junction (TJ) proteins (e.g. occludin, junctional adhesion molecule-A, claudins), basal ectoplasmic specialization proteins (e.g. N-cadherin), and gap junction proteins (e.g. connexin43). However, the regulators (e.g. protein kinases and phosphatases) that affect these proteins, such as their interaction with the cytoskeletal actin, which in turn confer cell adhesion at the TJ, remain largely unknown. We report herein that focal adhesion kinase (FAK) is a putative interacting partner of occludin, but not claudin-11 or junctional adhesion molecule-A. Immunohistochemistry and fluorescence microscopy studies illustrated that the expression of FAK in the seminiferous epithelium of adult rat testes was stage specific. FAK colocalized with occludin at the BTB in virtually all stages of the seminiferous epithelial cycle but considerably diminished in stages VIII-IX, at the time of BTB restructuring to facilitate the transit of primary leptotene spermatocytes. Using Sertoli cells cultured in vitro with established TJ-permeability barrier and ultrastructures of TJ, basal ectoplasmic specialization and desmosome-like junction that mimicked the BTB in vivo, FAK was shown to colocalize with occludin and zonula occludens-1 (ZO-1) at the Sertoli-Sertoli cell interface. When these Sertoli cell cultures were treated with CdCl(2) to perturb the TJ-barrier function, occludin underwent endocytic-mediated internalization in parallel with FAK and ZO-1. Thus, these findings demonstrate that FAK is an integrated regulatory component of the occludin-ZO-1 protein complex, suggesting that functional studies can be performed to study the role of FAK in BTB dynamics. PMID:19213829

  1. Adhesive strength of atherosclerotic plaque in a mouse model depends on local collagen content and elastin fragmentation.

    Wang, Ying; Johnson, John A; Fulp, Abigail; Sutton, Michael A; Lessner, Susan M

    2013-02-22

    Atherosclerotic plaque rupture is a major cause of myocardial infarction and ischemic stroke. The adhesive strength of the bond between a plaque and the vascular wall, measured as local energy release rate, G, is used for quantitative plaque stability estimation. We tested the hypothesis that adhesive strength varies with plaque composition. Matrix metalloproteinase-12 (MMP12) deficiency was previously reported to alter lesion composition. To estimate G values, peeling experiments are performed on aortic plaques from apolipoprotein E knockout (apoE KO) and apoE MMP12 double knockout (DKO) male mice after 8 months on high-fat diet. For plaques in apoE KO and apoE MMP12 DKO mice, experimental values for G differ significantly (paveraging 19.2J/m(2) and 12.1J/m(2), respectively. Histology confirms that plaques delaminate along their interface with the underlying internal elastic lamina (IEL) in both genotypes. Quantitative image analysis of stained tissue sections demonstrates a significant positive correlation (p<0.05) between local collagen content of lesions and G values in both genotypes, indicating that adhesive strength of plaques depends on local collagen content. Surprisingly, macrophage content of aortic plaques is neither significantly correlated with G values nor significantly different between genotypes. The IEL underlying plaques in apoE KO mice is significantly more fragmented (number of breaks and length of breaks) than in apoE MMP12 DKO mice, suggesting that elastin fragmentation also influences adhesion strength of plaques. Overall, our results suggest that plaques adhere more strongly to the underlying IEL in apoE KO mice than in apoE MMP12 DKO mice. PMID:23261250

  2. Evaluation of a new range of light-activated surgical adhesives for tissue repair in a porcine model

    Riley, Jill N.; Hodges, Diane E.; March, Keith L.; McNally-Heintzelman, Karen M.

    2001-05-01

    An in vitro study was conducted to determine the feasibility of using a new range of light-activated surgical adhesives for incision repair in a wide range of tissue types. Biodegradable polymer membranes of controlled porosity were fabricated with poly(L-lactic-co-glycolic acid) (PLGA) and salt particles using a solvent-casting and particulate- leaching technique. The porous membranes were doped with protein solder composed of 50%(w/v) bovine serum albumin solder and 0.5 mg/ml indocyanine green (ICG) dye mixed in deionized water. Tissue incisions were repaired using the surgical adhesive in conjunction with an 805-nm diode laser. Nine organs were tested ranging from skin to liver to the small intestine, as well as the coronary, pulmonary, carotid, femoral and splenetic arteries. Acute breaking strengths were measured and the data were analyzed by Student's T-test. Repairs formed on the small intestine were most successful followed by spleen, atrium, kidney, muscle and skin. The strongest vascular repairs were achieved in the carotid artery and femoral artery. The new surgical adhesive could possibly be used as a simple and effective method to stop bleeding and repair tissue quickly in an emergency situation, or as a substitute to mechanical staples or sutures in many clinical applications.

  3. Glutamine Supplementation Attenuates Expressions of Adhesion Molecules and Chemokine Receptors on T Cells in a Murine Model of Acute Colitis

    Yu-Chen Hou

    2014-01-01

    Full Text Available Background. Migration of T cells into the colon plays a major role in the pathogenesis in inflammatory bowel disease. This study investigated the effects of glutamine (Gln supplementation on chemokine receptors and adhesion molecules expressed by T cells in mice with dextran sulfate sodium- (DSS- induced colitis. Methods. C57BL/6 mice were fed either a standard diet or a Gln diet replacing 25% of the total nitrogen. After being fed the diets for 5 days, half of the mice from both groups were given 1.5% DSS in drinking water to induce colitis. Mice were killed after 5 days of DSS exposure. Results. DSS colitis resulted in higher expression levels of P-selectin glycoprotein ligand- (PSGL- 1, leukocyte function-associated antigen- (LFA- 1, and C-C chemokine receptor type 9 (CCR9 by T helper (Th and cytotoxic T (Tc cells, and mRNA levels of endothelial adhesion molecules in colons were upregulated. Gln supplementation decreased expressions of PSGL-1, LFA-1, and CCR9 by Th cells. Colonic gene expressions of endothelial adhesion molecules were also lower in Gln-colitis mice. Histological finding showed that colon infiltrating Th cells were less in the DSS group with Gln administration. Conclusions. Gln supplementation may ameliorate the inflammation of colitis possibly via suppression of T cell migration.

  4. Effect of turmeric powder (Curcuma longa L. and ascorbic acid on antioxidant capacity and oxidative status in rabbit burgers after cooking

    S. Mancini

    2016-06-01

    Full Text Available The aim of this study was to evaluate the effects of turmeric powder and ascorbic acid on lipid oxidation and antioxidant capacity in cooked rabbit burgers. The burgers were derived from 3 different formulations (C, control, with no additives; Tu with 3.5% of turmeric powder and AA with 0.1% of ascorbic acid and were stored at 4°C for 0 and 7 d and cooked. The lipid oxidation (thiobarbituric acid reactive substances [TBARS] and antioxidant capacity (2,2-azinobis-[3 ethylbenzothiazoline-6-sulfonic acid] {ABTS}, 1,1-diphenyl-2-pircydrazyl [DPPH] and ferric reducing ability [FRAP] were evaluated. A significant interaction between storage time and formulation (P<0.001 was observed for DPPH, FRAP and TBARS in cooked burgers. At day 0 and day 7, the DPPH value was higher in Tu and AA compared to C burgers. At day 0, C showed a lower level of FRAP than the Tu and AA burgers. At day 7, the FRAP values tended to decrease but remained significantly higher in Tu and AA compared to C burgers. Lipid oxidation at day 0 in Tu and AA showed lower TBARS values compared to C burgers. The addition of 3.5% turmeric powder in rabbit burgers exerts an antioxidant effect during storage and it seems more effective in controlling lipid oxidation than ascorbic acid after cooking.

  5. Psychological stress increases expression of aortic plaque intercellular adhesion molecule-1 and serum inflammatory cytokines in atherosclerotic rabbit model

    Muwei Li; Xianpei Wang; Lei Yang; Chuanyu Gao; Yexin Ma

    2008-01-01

    Plaque rupture,platelet aggregation,and thrombogenesis are the main mechanisms of acute coronary syndrome (ACS),and inflammation factors play key roles in plaque unstability.Psychological stress promotes acute inflammatory response,leading to increased circulating levels of C-reactive protein (CRP),IL-6,and serum intercellular adhesion molecule (sICAM)-1.But it is not clear that whether psychological stress has a direct effect on atherosclerotic plaque stability.The purpose of this study was to investigate effects of chronic psychological stress on inflammatory marker (ICAM-1 ) in atherosclerotic plaque,and inflammatory markers in peripheral blood.Materials and methods Sixty male rabbits were randomized into 2 groups:the control group (n =10) and the atherosclerotic group (n =50).The latter were fed on high fatty diet and were given a large dose of vitamin D3 (3 600 000IU/kg) via intraperitoneal injection.After 8 weeks,the atherosclerotic model was estaslished.Then the 50 atherosclerotic model rabbits were divided into 3 subgroups:no-stress subgroup (n = 16),physiological stress subgroup (n = 16) and psychological stress subgroup (n =18).In physiological stress subgroup and psychological stress subgroup,drinking was cut from twice a day to once a day.At the same time,psychological stress subgroup was given empty bottle stress,and this process lasted for 2 weeks.One hour after the last stress,the blood samples were collected and the serum levels of CRP,IL-6 amd ICAM-1 were tested by radioimmunoassay or enzyme linked immunosorbent assay.The aorta and heart were extracted for pathology examination,and the express of ICAM-1 was tested by immunohistochemical examination.Results (1) After effective atherosclerotic animal model construction,the expression of ICAM-1 in aorta was higher in atherosclerotic group than that in control group (P<0.01),and was notably higher in psychological stress subgroup than that in no-stress subgroup or in physiological stress subgroup (2

  6. PH dependent adhesive peptides

    Tomich, John; Iwamoto, Takeo; Shen, Xinchun; Sun, Xiuzhi Susan

    2010-06-29

    A novel peptide adhesive motif is described that requires no receptor or cross-links to achieve maximal adhesive strength. Several peptides with different degrees of adhesive strength have been designed and synthesized using solid phase chemistries. All peptides contain a common hydrophobic core sequence flanked by positively or negatively charged amino acids sequences.

  7. Elastocapilllarity in insect adhesion: the case of beetle adhesive hair

    Gernay, Sophie; Gilet, Tristan; Lambert, Pierre; Federle, Walter

    2014-11-01

    The feet of many insects are covered with dense arrays of hair-like structures called setae. Liquid capillary bridges at the tip of these micrometric structures are responsible for the controlled adhesion of the insect on a large variety of substrates. The resulting adhesion force can exceed several times the body weight of the insect. The high aspect-ratio of setae suggests that flexibility is a key ingredient in this capillary-based adhesion mechanism. There is indeed a strong coupling between their elastic deformation and the shape of the liquid meniscus. In this experimental work, we observe and quantify the local deflection of dock beetle seta tips under perpendicular loading using interference microscopy. Our results are then interpreted in the light of an analytic model of elastocapillarity. This research has been funded by the FRIA/FNRS and the Interuniversity Attraction Poles Programme (IAP 7/38 MicroMAST) initiated by the Belgian Science Policy Office.

  8. Painlevé Property, Bäcklund Transformations and Rouge Wave Solutions of (3 + 1)-Dimensional Burgers Equation

    Burgers equation is the simplest one in soliton theory, which has been widely applied in almost all the physical branches. In this paper, we discuss the Painlevé property of the (3+1)-dimensional Burgers equation, and then Bäcklund transformation is derived according to the truncated expansion of the obtained Painlevé analysis. Using the Bäcklund transformation, we find the rouge wave solutions to the equation via the multilinear variable separation approach. And we also give an exact solution obtained by general variable separation approach, which is proved to possess abundant structures. (general)

  9. A Modified Three-Level Average Linear-Implicit Finite Difference Method for the Rosenau-Burgers Equation

    Jiraporn Janwised; Ben Wongsaijai; Thanasak Mouktonglang; Kanyuta Poochinapan

    2014-01-01

    We introduce a new technique, a three-level average linear-implicit finite difference method, for solving the Rosenau-Burgers equation. A second-order accuracy on both space and time numerical solution of the Rosenau-Burgers equation is obtained using a five-point stencil. We prove the existence and uniqueness of the numerical solution. Moreover, the convergence and stability of the numerical solution are also shown. The numerical results show that our method improves the accuracy of the solu...

  10. A Modified Three-Level Average Linear-Implicit Finite Difference Method for the Rosenau-Burgers Equation

    Jiraporn Janwised

    2014-01-01

    Full Text Available We introduce a new technique, a three-level average linear-implicit finite difference method, for solving the Rosenau-Burgers equation. A second-order accuracy on both space and time numerical solution of the Rosenau-Burgers equation is obtained using a five-point stencil. We prove the existence and uniqueness of the numerical solution. Moreover, the convergence and stability of the numerical solution are also shown. The numerical results show that our method improves the accuracy of the solution significantly.

  11. Entropy Stable Staggered Grid Spectral Collocation for the Burgers' and Compressible Navier-Stokes Equations

    Carpenter, Mark H.; Parsani, Matteo; Fisher, Travis C.; Nielsen, Eric J.

    2015-01-01

    Staggered grid, entropy stable discontinuous spectral collocation operators of any order are developed for Burgers' and the compressible Navier-Stokes equations on unstructured hexahedral elements. This generalization of previous entropy stable spectral collocation work [1, 2], extends the applicable set of points from tensor product, Legendre-Gauss-Lobatto (LGL) to a combination of tensor product Legendre-Gauss (LG) and LGL points. The new semi-discrete operators discretely conserve mass, momentum, energy and satisfy a mathematical entropy inequality for both Burgers' and the compressible Navier-Stokes equations in three spatial dimensions. They are valid for smooth as well as discontinuous flows. The staggered LG and conventional LGL point formulations are compared on several challenging test problems. The staggered LG operators are significantly more accurate, although more costly to implement. The LG and LGL operators exhibit similar robustness, as is demonstrated using test problems known to be problematic for operators that lack a nonlinearly stability proof for the compressible Navier-Stokes equations (e.g., discontinuous Galerkin, spectral difference, or flux reconstruction operators).

  12. Particle adhesion and removal

    Mittal, K L

    2015-01-01

    The book provides a comprehensive and easily accessible reference source covering all important aspects of particle adhesion and removal.  The core objective is to cover both fundamental and applied aspects of particle adhesion and removal with emphasis on recent developments.  Among the topics to be covered include: 1. Fundamentals of surface forces in particle adhesion and removal.2. Mechanisms of particle adhesion and removal.3. Experimental methods (e.g. AFM, SFA,SFM,IFM, etc.) to understand  particle-particle and particle-substrate interactions.4. Mechanics of adhesion of micro- and  n

  13. Nucleation and growth of cadherin adhesions

    Cell-cell contact formation relies on the recruitment of cadherin molecules and their anchoring to actin. However, the precise chronology of events from initial cadherin trans-interactions to adhesion strengthening is unclear, in part due to the lack of access to the distribution of cadherins within adhesion zones. Using N-cadherin expressing cells interacting with N-cadherin coated surfaces, we characterized the formation of cadherin adhesions at the ventral cell surface. TIRF and RIC microscopies revealed streak-like accumulations of cadherin along actin fibers. FRAP analysis indicated that engaged cadherins display a slow turnover at equilibrium, compatible with a continuous addition and removal of cadherin molecules within the adhesive contact. Association of cadherin cytoplasmic tail to actin as well as actin cables and myosin II activity are required for the formation and maintenance of cadherin adhesions. Using time lapse microscopy we deciphered how cadherin adhesions form and grow. As lamellipodia protrude, cadherin foci stochastically formed a few microns away from the cell margin. Neo-formed foci coalesced aligned and coalesced with preformed foci either by rearward sliding or gap filling to form cadherin adhesions. Foci experienced collapse at the rear of cadherin adhesions. Based on these results, we present a model for the nucleation, directional growth and shrinkage of cadherin adhesions

  14. Comparison of scaffold-enhanced albumin and n-butyl-cyanoacrylate adhesives for joining of tissue in a porcine model

    McNally-Heintzelman, Karen M.; Riley, Jill N.; Heintzelman, Douglas L.

    2003-06-01

    An ex vivo study was conducted to compare the tensile strength of tissue samples repaired using three different techniques: (i) application of a scaffold-enhanced light-activated albumin protein solder, (ii) application of a scaffold-enhanced n-butyl-cyanoacrylate adhesive, and (iii) repair via conventional suture technique. Biodegradable polymer scaffolds of controlled porosity were fabricated with poly(L-lactic-co-glycolic acid) and salt particles using a solvent-casting and particulate-leaching technique. Group I porous scaffolds were doped with protein solder composed of 50%(w/v) bovine serum albumin solder and 0.5mg/ml indocyanine green dye mixed in deionized water, and activated with an 808-nm diode laser. Group II scaffolds were doped with n-butyl-cyanoacrylate, and required no light-activation. No stay sutures were required for Group I or II experiments. Group III repairs were performed using a single 4-0 suture. Thirteen organs were tested ranging from skin to liver to the small intestine, as well as the coronary, pulmonary, carotid, femoral and splenic arteries. Acute breaking strengths were measured and the data were analyzed by Student"s T-test. Using the protein solder of Group I, repairs formed on the ureter were most successful followed by small intestine, sciatic nerve, spleen, atrium, kidney, muscle, skin and ventricle. The strongest vascular repairs were achieved in the carotid artery and femoral artery. Overall, the tensile strength of Group III repairs performed via suture techniques were equivalent in magnitude to that of Group I repairs, however, a larger variance was observed in the suture repair group. Group II repairs utilizing the cyanoacrylate-doped scaffold all performed extremely well. Bonds formed using the Group II adhesive were approximately 30% stronger than Group I and III organ repairs and approximately 20% stronger than Group I and III vascular repairs. Application of the polymer scaffold assists in tissue alignment and reduces

  15. The Almost Periodic Solution of a KdV-Burgers Equation%一类KdV-Burgers方程的概周期解

    施秀莲

    2014-01-01

    KdV-Burgers方程出现在许多物理模型中,是非线性科学领域中的重要模型之一。本文讨论一类具有阻尼和非齐次项的KdV-Burgers方程的概周期解存在性问题。首先利用Galerkin方法构造出方程的有界解,并利用一些数学不等式给出这个解的先验估计;然后利用所得的先验估计和标准的紧致性方法证明方程广义解的存在性;最后证明当方程的非齐次项函数是关于时间变量的概周期函数时,该广义解就是方程的概周期解。%The KdV-Burgers equation appears in many physical models. It is one of the most important models in nonlinear science. This paper mainly investigates the existence of the almost periodic solution to a class of KdV-Burgers equations with damping and non-homogeneous terms. The bounded solution to this equation is constructed by using the Galerkin method and the priori estimates are given by employing some mathematical inequalities. Then the existence of the generalized solution is proved by means of the obtained priori estimates and the standard compact method. Finally, it is proved that the generalized solution is the almost periodic solution to the discussed equation when the non-homogeneous term is an almost periodic function with respect to the time variable.

  16. Repairing Fetal Membranes with a Self-adhesive Ultrathin Polymeric Film: Evaluation in Mid-gestational Rabbit Model.

    Pensabene, Virginia; Patel, Premal P; Williams, Phillip; Cooper, Trisha L; Kirkbride, Kellye C; Giorgio, Todd D; Tulipan, Noel B

    2015-08-01

    Preterm premature rupture of membranes causes 40% of all preterm births, affecting 150000 women each year in the United States. Prenatal diagnostic procedures and surgical interventions increase incidence of adverse events, leading to iatrogenic membrane rupture after a fetoscopic procedure in 45% of cases. We propose an ultrathin, self-adherent, poly-L-lactic acid patch ("nanofilm") as a reparative wound closure after endoscopic/fetoscopic procedures. These nanofilms are compatible with application in wet conditions and with minimally invasive instrumentation. Ex vivo studies to evaluate the nanofilm were conducted using human chorion-amnion (CA) membranes. A custom-built inflation device was used for mechanical characterization of CA membranes and for assessment of nanofilm adhesion and sealing of membrane defects up to 3 mm in size. These ex vivo tests demonstrated the ability of the nanofilm to seal human CA defects ranging in size from 1 to 3 mm in diameter. In vivo survival studies were conducted in 25 mid-gestational rabbits, defects were created by perforating the uterus and the CA membranes and subsequently using the nanofilm to seal these wounds. These in vivo studies confirmed the successful sealing of defects smaller than 3 mm observed ex vivo. Histological analysis of whole harvested uteri 7 days after surgery showed intact uterine walls in 59% of the nanofilm repaired fetuses, along with increased uterine size and intrauterine development in 63% of the cases. In summary, we have developed an ultrathin, self-adhesive nanofilm for repair of uterine membrane defects. PMID:25549772

  17. Adhesion force studies of nanofibers and nanoparticles.

    Xing, Malcolm; Zhong, Wen; Xu, Xiuling; Thomson, Douglas

    2010-07-20

    Surface adhesion between nanofibers and nanoparticles has attracted attention for potential biomedical applications, but the measurement has not been reported. Adhesion forces were measured using a polystyrene (PS) nanoparticle attached to an atomic force microscopy (AFM) tip/probe. Electrospun PS nanofibers of different diameters were tapped with the probe to study the effect of fiber diameters on adhesion force. Both AFM experiments and numerical models suggest that the adhesion force increases with increased fiber diameters. Numerical models further demonstrated that local deformation of the fiber surface, including the flattening of surface asperities and the nanofiber wrapping around the particle during contact, may have a significant impact on the adhesion force. The adhesion forces are in the order of 100 nN, much smaller than the adhesion forces of the gecko foot hair, but much larger than that of the receptor-ligand pair, antibody-antigen pair, and single-stranded DNA from a substrate. Adhesion forces of nanofibers with roughness were predicted by numerical analysis. This study is expected to provide approaches and information useful in the design of nanomedicine and scaffold based on nanofibers for tissue engineering and regenerative medicine. PMID:20552953

  18. An injured tissue affects the opposite intact peritoneum during postoperative adhesion formation

    Suzuki, Tatsuya; Kono, Toru; Bochimoto, Hiroki; Hira, Yoshiki; Watanabe, Tsuyoshi; Furukawa, Hiroyuki

    2015-01-01

    The pathophysiology of adhesion formation needs to be clarified to reduce the adhesion-related morbidity. The epithelial characteristics of the peritoneum suggest a protective role against adhesion formation, yet how the peritoneum is involved in adhesion formation is not well characterized. We microscopically observed an experimental model of adhesion formation to investigate the effects of an injured tissue on the opposite intact peritoneum. Adhesions were induced between injured and intact...

  19. A note on the inviscid limit of the Benjamin-Ono-Burgers equation in the energy space

    Molinet, Luc

    2011-01-01

    In this paper we study the inviscid limit of the Benjamin-Ono-Burgers equation in the energy space $ H^{1/2} (\\R) $ or $ H^{1/2}(\\T) $. We prove the strong convergence in the energy space of the solution to this equation toward the solution of the Benjamin-Ono equation as the dissipation coefficient converges to $ 0 $.

  20. Radiation-curable adhesives

    Radiation-curable adhesives may be classified into two broad categories. In the first category, adhesive bonding occurs as a direct result of irradiation. The second category includes pressure-sensitive and hot-melt adhesives, which are composed of linear or lightly cross-linked polymers prepared by a radiation-induced polymerization reaction. This chapter is mainly concerned with radiation-curable adhesives of the first category. The various adhesive types are discussed and adhesive performance is examined, particularly in relation to the chemistry and chemical technology which underlies the individual materials. A description of a limited number of representative applications is included as is an outline of recent developments of curing and dispensing equipment. 268 refs., 14 figs., 13 tabs

  1. Prevention of bacterial adhesion

    Klemm, Per; Vejborg, Rebecca Munk; Hancock, Viktoria

    2010-01-01

    Management of bacterial infections is becoming increasingly difficult due to the emergence and increasing prevalence of bacterial pathogens that are resistant to available antibiotics. Conventional antibiotics generally kill bacteria by interfering with vital cellular functions, an approach that....... As such, adhesion represents the Achilles heel of crucial pathogenic functions. It follows that interference with adhesion can reduce bacterial virulence. Here, we illustrate this important topic with examples of techniques being developed that can inhibit bacterial adhesion. Some of these will...

  2. Transcriptional analysis of genes associated with stress and adhesion in Lactobacillus acidophilus NCFM during the passage through an in vitro gastrointestinal tract model.

    Weiss, G; Jespersen, L

    2010-01-01

    The aim of the present study was to investigate the transcription of genes associated with stress and adhesion in Lactobacillus acidophilus NCFM during the passage through an in vitro gastrointestinal tract model. As acidified milk exerted a protective effect on the bacteria leading to increased survival, the gene expression studies were carried out with pre-inoculation of L. acidophilus NCFM in acidified milk. The induction of the genes encoding the stress-related proteins GroEL, DnaK and ClpP, and adhesion-related genes encoding mucin-binding proteins, fibronectin-binding protein and S-layer was analyzed by real-time PCR. The genes encoding GroEL, DnaK and ClpP were significantly up-regulated (9- to 16-fold) during gastric digestion and declined upon subsequent duodenal digestion. The genes encoding mucin-binding proteins and fibronectin-binding protein were not influenced by saliva and gastric juice, but they were significantly upregulated during incubation in duodenal juice and bile (6- to 7-fold). A significant induction of the gene encoding the S-layer protein was not detected. Our results give a better understanding of the functionality of L. acidophilus NCFM and other probiotics during passage through the gastrointestinal tract; hence, they provide an implementable basis for the selection of prospective probiotic candidates. PMID:20559014

  3. Biomimetic design of platelet adhesion inhibitors to block integrin α2β1-collagen interactions: I. Construction of an affinity binding model.

    Zhang, Lin; Sun, Yan

    2014-04-29

    Platelet adhesion on a collagen surface through integrin α2β1 has been proven to be significant for the formation of arterial thrombus. However, the molecular determinants mediating the integrin-collagen complex remain unclear. In the present study, the dynamics of integrin-collagen binding and molecular interactions were investigated using molecular dynamics (MD) simulations and molecular mechanics-Poisson-Boltzmann surface area (MM-PBSA) analysis. Hydrophobic interaction is identified as the major driving force for the formation of the integrin-collagen complex. On the basis of the MD simulation and MM-PBSA results, an affinity binding model (ABM) of integrin for collagen is constructed; it is composed of five residues, including Y157, N154, S155, R288, and L220. The ABM has been proven to capture the major binding motif contributing 84.8% of the total binding free energy. On the basis of the ABM, we expect to establish a biomimetic design strategy of platelet adhesion inhibitors, which would be beneficial for the development of potent peptide-based drugs for thrombotic diseases. PMID:24697616

  4. Flow of Generalized Burgers' Fluid between Side Walls Induced by Sawtooth Pulses Stress

    Qamar Sultan

    2016-01-01

    Full Text Available This paper presents the unsteady magnetohydrodynamic (MHD flow of a generalized Burgers' fluid between two parallel side walls perpendicular to a plate. The flow is generated from rest at time induced by sawtooth pulses stress applied to the bottom plate. The solutions obtained by means of the Laplace and the Fourier cosine and sine transforms in this order are presented as a sum between the corresponding Newtonian and non-Newtonian contributions. We investigate the effect of magnetic field and permeability on the fluid motion by a numerical procedure for the inverse Laplace transform, namely Stehfest's algorithm. Moreover, the influence of side walls on the fluid motion, the effect of pulse period, magnetic and porosity parameters and material parameters is presented by graphical illustrations.

  5. Investigation of detonation velocity in heterogeneous explosive system using the reactive Burgers' analog

    Di Labbio, G.; Kiyanda, C. B.; Mi, X.; Higgins, A. J.; Nikiforakis, N.; Ng, H. D.

    2016-06-01

    In this study, the applicability of the Chapman-Jouguet (CJ) criterion is tested numerically for heterogeneous explosive media using a simple detonation analog. The analog system consists of a reactive Burgers' equation coupled with an Arrhenius type reaction wave, and the heterogeneity of the explosive media is mimicked using a discrete energy source approach. The governing equation is solved using a second order, finite-volume approach and the average propagation velocity of the discrete detonation is determined by tracking the leading shock front. Consistent with previous studies, the averaged velocity of the leading shock front from the unsteady numerical simulations is also found to be in good agreement with the velocity of a CJ detonation in a uniform medium wherein the energy source is spatially homogenized. These simulations have thus implications for whether the CJ criterion is valid to predict the detonation velocity in heterogeneous explosive media.

  6. Multilinear Variable Separation Approach in (3+1)-Dimensions: the Burgers Equation

    应金萍; 楼森岳

    2003-01-01

    The multi-linear variable separation approach has been proved to be very useful in solving many (2+ 1 )-dimensional integrable systems. Taking the (3+1)-dimensional Burgers equation as a simple example, here we extend the multi-linear variable separation approach to (3+1)-dimensions. The form of the universal formula obtained from many (2+1)-dimensional system is still valid. However, a more general arbitrary function (with three independent variables) has been included in the formula. Starting from the universal formula, one may obtain abundant (3+1)-dimensional localized excitations. In particular, we display a special paraboloid-type camber soliton solution and a dipole-type dromion solution which is localized in all directions.

  7. Structure of shocks in Burgers turbulence with L\\'evy noise initial data

    Abramson, Joshua

    2012-01-01

    We study the structure of the shocks for the inviscid Burgers equation in dimension 1 when the initial velocity is given by L\\'evy noise, or equivalently when the initial potential is a two-sided L\\'evy process $\\psi_0$. When $\\psi_0$ is abrupt in the sense of Vigon or has bounded variation with $\\lim_{|h| \\downarrow 0} h^{-2} \\psi_0(h) = \\infty$, we prove that the set of points with zero velocity is regenerative, and that in the latter case this set is equal to the set of Lagrangian regular points, which is non-empty. When $\\psi_0$ is abrupt we show that the shock structure is discrete. When $\\psi_0$ is eroded we show that there are no rarefaction intervals.

  8. Statistical Theory for the Stochastic Burgers Equation in the Inviscid Limit

    Weinan, E; Eijnden, Eric Vanden

    1999-01-01

    A statistical theory is developed for the stochastic Burgers equation in the inviscid limit. Master equations for the probability density functions of velocity, velocity difference and velocity gradient are derived. No closure assumptions are made. Instead closure is achieved through a dimension reduction process, namely the unclosed terms are expressed in terms of statistical quantities for the singular structures of the velocity field, here the shocks. Master equations for the environment of the shocks are further expressed in terms of the statistics of singular structures on the shocks, namely the points of shock generation and collisions. The scaling laws of the structure functions are derived through the analysis of the master equations. Rigorous bounds on the decay of the tail probabilities for the velocity gradient are obtained using realizability constraints. We also establish that the probability density function of the velocity gradient has a left power tail with exponent -7/2.

  9. Probabilistic Aspects of Equation of Motion of Forced Burgers and Navier-Stokes Turbulence

    Nakazawa, H.

    1980-11-01

    Physical requirements and limitations on the force terms of the equations of motion for forced Burgers turbulence and for a class of forced, incompressible Navier-Stokes turbulence are discussed from probabilistic point of view. A basic problem, to determine the appropriate normalization of equations of motion, is answered. The normalization and the physical requirements are shown to stipulate that the force terms must bear Gaussian and white character for their time dependence as an exclusive consequence of the central limit theorem of Rosenblatt. A range of physical phenomena is thus pointed out to substantialize Kraichnan-Wyld-Edwards type of equations of motion for turbulence. A problem is found in the definition, as stochastic partial differential equations, of such equations with Gaussian-white-noise forces in the inviscid limit, and a possible way to circumvent the difficulty is shown to be inherent in the central limit theorem itself.

  10. Asymptotic behavior of a generalized Burgers' equation solutions on a finite interval

    The article is concerned with the study of asymptotic behavior of solutions of the Burgers equation and its generalizations with initial value — boundary problem on a finite interval, with constant boundary conditions. Since these equations take a dissipation into account, it is naturally to presuppose that any initial profile will evolve to an invariant time-independent solution with the same boundary values. Yet the answer happens to be slightly more complex. There are three possibilities: the initial profile may regularly decay to an invariant solution; or a Heaviside-type gap develops through a dispersive shock and multi-oscillations; or, exotically, an asymptotic limit is a 'frozen multi-oscillation' piecewise-differentiable solution, composed of different smooth invariant solutions

  11. Using plukenetia volubilis (sacha inchi to improve the nutritional components of burger

    Daniela Baldeón Clavijo

    2015-06-01

    Full Text Available (Received: 2015/03/18 - Accepted: 2015/05/27Three levels of paste Plukenetia volubilis (Sacha Inchi consisting of 10, 15% and 20% were evaluated to replace the weight percent lard conventionally used to improve the nutritional quality of the common hamburger, compared with a reference group. The experimental units were 10 burgers, weighing 100 g. each and a total of 120 were analyzed in a completely randomized design with three replications. The research was conducted in the Universidad Estatal Amazónica and bromatológics and microbiological analyzes to determine the quality of the raw material and products are made in laboratory of the Faculty of Chemical Sciences of the Universidad Central del Ecuador. As supplements sensory tests and studies Benefit / Cost performed. The results show the variation of 10% pulp Sacha Inchi as the most recommended for use in industry.

  12. Nonlinear wave solutions of the three-dimensional Zakharov-Kuznetsov-Burgers equation in dusty plasma

    Seadawy, Aly R.

    2015-12-01

    The propagation of dust-ion-acoustic waves with high-energy electrons and positrons in three-dimensional is considered. The Zakharov-Kuznetsov-Burgers (ZKB) equations for the dust-ion-acoustic waves in dusty plasmas is obtained. The conservations laws and integrals of motion for the ZKB equation are deduced. In the present study, by applying the modified direct algebraic method, we found the electric field potential, electric field and quantum statistical pressure in form water wave solutions for three-dimensional ZKB equation. The solutions for the ZKB equation are obtained precisely and efficiency of the method can be demonstrated. The stability of the obtained solutions and the movement role of the waves by making the graphs of the exact solutions are discussed and analyzed.

  13. A unified approach for the numerical solution of time fractional Burgers' type equations

    Esen, A.; Bulut, F.; Oruç, Ö.

    2016-04-01

    In this paper, a relatively new approach is devised for obtaining approximate solution of time fractional partial differential equations. Time fractional diffusion equation and time fractional Burgers-Fisher equation are solved with Haar wavelet method where fractional derivatives are Caputo derivative. Time discretization of the problems made by L1 discretization formula and space derivatives discretized by Haar series. L2 and L_{∞} error norms are used for measuring accuracy of the proposed method. Numerical results obtained with proposed method compared with exact solutions as well as with available results from the literature. The numerical results verify the feasibility of Haar wavelet combined with L1 discretization formula for the considered problems.

  14. Existence of solutions to Burgers equations in domains that can be transformed into rectangles

    Yassine Benia

    2016-06-01

    Full Text Available This work is concerned with Burgers equation $\\partial _{t}u+u\\partial_x u-\\partial _x^2u=f$ (with Dirichlet boundary conditions in the non rectangular domain $\\Omega =\\{(t,x\\in R^2;\\ 0

  15. The evolution of adhesiveness as a social adaptation.

    Garcia, Thomas; Doulcier, Guilhem; De Monte, Silvia

    2015-01-01

    Cellular adhesion is a key ingredient to sustain collective functions of microbial aggregates. Here, we investigate the evolutionary origins of adhesion and the emergence of groups of genealogically unrelated cells with a game-theoretical model. The considered adhesiveness trait is costly, continuous and affects both group formation and group-derived benefits. The formalism of adaptive dynamics reveals two evolutionary stable strategies, at each extreme on the axis of adhesiveness. We show that cohesive groups can evolve by small mutational steps, provided the population is already endowed with a minimum adhesiveness level. Assortment between more adhesive types, and in particular differential propensities to leave a fraction of individuals ungrouped at the end of the aggregation process, can compensate for the cost of increased adhesiveness. We also discuss the change in the social nature of more adhesive mutations along evolutionary trajectories, and find that altruism arises before directly beneficial behavior, despite being the most challenging form of cooperation. PMID:26613415

  16. Controllable and switchable capillary adhesion mechanism for bio-adhesive pads: Effect of micro patterns

    ZHANG XiangJun; LIU Yuan; LIU YongHe; AHMED S.I.-U.

    2009-01-01

    Some insects and animals, such as bugs, grasshoppers and tree frogs, realize their efficient adhesion mechanism to glass surface, wall and ceiling by injecting a wetting liquid thin film into the pad-substrate contact area. Their ability to control adhesion (attaching or detaching from a surface) is in many cases connected to the contact geometry and surface patterns of their attachment pads. This paper focuses on the dependence of the capillary adhesion (wet adhesion) on the micro patterns of the bio-adhesive pads. The objective is to reveal the possible mechanism for a bio-adhesive pad to control capillary force through adjusting its micro-scale surface pattern and topography. A capillary adhesion force model is built up taking account of the combined role of micro-dimple geometry as well as the wetting behavior of the confined liquid thin film. Calculated results of the apparent contact angle on the regularly micro-dimpled surfaces are compared with and in good agreement with the experimental measurements. Simulation of the capillary adhesion force reveals that it is controllable in a large mag-nitude by adjusting a dimensionless surface pattern parameter k defined as a/(a+b), where a is the dia-meter of micro dimple, and (a+b) is the side length of one pattern cell. When adjusting the parameter k more than 0.75, the capillary adhesion force could be switchable from attractive to repulsive. This effect of micro patterns on the interfacial capillary force is proved to be dominant when the pad-substrate clearance decreases to the nano/micrometer scale. These results indicate that a controllable and switchable capillary adhesive mechanism might be utilized by a living insect or animal to realize its stable adhesion and quick releasing movement through adjusting the micro-pattern topography of its bio-adhesive pad.

  17. Tissue adhesives in otorhinolaryngology

    Schneider, Gerlind

    2009-01-01

    Full Text Available The development of medical tissue adhesives has a long history without finding an all-purpose tissue adhesive for clinical daily routine. This is caused by the specific demands which are made on a tissue adhesive, and the different areas of application. In otorhinolaryngology, on the one hand, this is the mucosal environment as well as the application on bones, cartilage and periphery nerves. On the other hand, there are stressed regions (skin, oral cavity, pharynx, oesophagus, trachea and unstressed regions (middle ear, nose and paranasal sinuses, cranial bones. But due to the facts that adhesives can have considerable advantages in assuring surgery results, prevention of complications and so reduction of medical costs/treatment expenses, the search for new adhesives for use in otorhinolaryngology will be continued intensively. In parallel, appropriate application systems have to be developed for microscopic and endoscopic use.

  18. Modelling the Fracture Behaviour of Adhesively-Bonded Joints as a Function of Test Rate - A Rate Dependent CZM is Required to Predict the Full Range of Behaviour

    Ivankovic, Alojz; Karac, Aleksandar; Blackman, B.R.K.; et al

    2011-01-01

    Adhesive bonding of lightweight, high-performance materials is regarded as a key enabling technology for the development of vehicles with increased crashworthiness, better fuel economy and reduced exhaust emissions. However, as automotive structures can be exposed to impact events during service, it is necessary to gain a sound understanding of the performance of adhesive joints under different rates of loading. Therefore, characterising the behaviour of adhesive joint...

  19. Tubular occlusion prevents water-treeing and through-and-through fluid movement in a single-bottle, one-step self-etch adhesive model

    King, NM; Tay, FR; Pashley, DH; Hiraishi, N.; Imazato, S.; Rueggeberg, FA; Salz, U; Zimmermann, J.

    2005-01-01

    Water entrapment occurs at resin-dentin interfaces of one-step self-etch adhesives. We hypothesized that by preventing water fluxes from dentin, any water entrapment would be attributed to incomplete removal of adhesive solvents. We tested this hypothesis by bonding to transparent carious dentin containing occluded dentinal tubules. An experimental single-bottle, one-step self-etch adhesive was applied to flat surfaces of caries-affected dentin surrounded by sound dentin, with or without pulp...

  20. Analysis on Adhesively-Bonded Joints of FRP-steel Composite Bridge under Combined Loading: Arcan Test Study and Numerical Modeling

    Xu Jiang; Xuhong Qiang; Henk Kolstein; Frans Bijlaard

    2016-01-01

    The research presented in this paper is an experimental study and numerical analysis on mechanical behavior of the adhesively-bonded joint between FRP sandwich bridge deck and steel girder. Generally, there are three typical stress states in the adhesively-bonded joint: shear stress, tensile stress, and combination of both. To realize these stress states in the adhesively-bonded joint during tests, a specific loading device is developed with the capacity of providing six different loading ang...

  1. Targeted gene disruption in Candida parapsilosis demonstrates a role for CPAR2_404800 in adhesion to a biotic surface and in a murine model of ascending urinary tract infection.

    Bertini, Alessia; Zoppo, Marina; Lombardi, Lisa; Rizzato, Cosmeri; De Carolis, Elena; Vella, Antonietta; Torelli, Riccardo; Sanguinetti, Maurizio; Tavanti, Arianna

    2016-02-17

    Candida parapsilosis is an emerging opportunistic pathogen, second in frequency only to C. albicans and commonly associated with both mucosal and systemic infections. Adhesion to biotic surfaces is a key step for the development of mycoses. The C. parapsilosis genome encodes 5 predicted agglutinin-like sequence proteins and their precise role in the adhesion process still remains to be elucidated. In this study, we focused on the putative adhesin Cpar2_404800, in view of its high homology to the most important adhesion molecule in C. albicans. Two independent lineages of C. parapsilosis CPAR2_404800 heterozygous and null mutants were obtained by site-specific deletion. CPAR2_404800 mutants did not differ from wild-type strain in terms of in vitro growth or in their ability to undergo morphogenesis. However, when compared for adhesion to a biotic surface, CPAR2_404800 null mutants exhibited a marked reduction in their adhesion to buccal epithelial cells (>60% reduction of adhesion index). Reintroduction of one copy of CPAR2_404800 gene in the null background restored wild type phenotype. A murine model of urinary tract infection was used to elucidate the in vivo contribution of CPAR2_404800. A 0.5 and 1 log10 reduction in colony forming unit numbers (per gram) was observed respectively in bladder and kidneys obtained from mice infected with null mutant compared to wild-type infected ones. Taken together, these findings provide the first evidence for a direct role of CPAR2_404800 in C. parapsilosis adhesion to host surfaces and demonstrate its contribution to the pathogenesis of murine urinary candidiasis. PMID:26632333

  2. Fabrication and characterization of hierarchical nanostructured smart adhesion surfaces.

    Lee, Hyungoo; Bhushan, Bharat

    2012-04-15

    The mechanics of fibrillar adhesive surfaces of biological systems such as a Lotus leaf and a gecko are widely studied due to their unique surface properties. The Lotus leaf is a model for superhydrophobic surfaces, self-cleaning properties, and low adhesion. Gecko feet have high adhesion due to the high micro/nanofibrillar hierarchical structures. A nanostructured surface may exhibit low adhesion or high adhesion depending upon fibrillar density, and it presents the possibility of realizing eco-friendly surface structures with desirable adhesion. The current research, for the first time uses a patterning technique to fabricate smart adhesion surfaces: single- and two-level hierarchical synthetic adhesive structure surfaces with various fibrillar densities and diameters that allows the observation of either the Lotus or gecko adhesion effects. Contact angles of the fabricated structured samples were measured to characterize their wettability, and contamination experiments were performed to study for self-cleaning ability. A conventional and a glass ball attached to an atomic force microscope (AFM) tip were used to obtain the adhesive forces via force-distance curves to study scale effect. A further increase of the adhesive forces on the samples was achieved by applying an adhesive to the surfaces. PMID:22285098

  3. Entrepreneur, social capital and the survival of Afrikaner business on the Witwatersrand, 1930 – 2007: the case of Burgers Brothers Clothing enterprise.

    Verhoef, Grietjie

    2009-01-01

    • Opsomming: Die ekonomiese afswaaifase van die 1930s is verswaar deur die geweldige droogte, plae en peste in die landbou en toenemende verarming onder blanke Suid-Afrikaners. Verstedeliking het een oorlewingstrategie gebied. Ty Burgers het ‘n klerewinkel begin met as teikenmark die verarmde blankes veral verarmde Afrikaners op die Witwatersrand. Hierdie artikel maak gebruik van sosiale kapitaalteorie om die vestiging van nuwe netwerke deur die Burgers onderneming in die sake-omgewing te...

  4. Pengaruh Keunikan Produk Terhadap Terciptanya Word of Mouth pada Produk Burger (Studi pada Usaha “Rumah Burger” Jln. Medan Area Selatan – Medan)

    Lubis, Rini Dwi Martha

    2015-01-01

    Persaingan dunia usaha saat ini sangatlah ketat. Untuk dapat memenangkan persaingan dan mempertahankan kelangsungan hidupnya, suatu usaha dituntut untuk mengembangkan strategi pemasaran yang tepat. Salah satunya adalah dengan mengembangkan produk unik yang mampu memikat hati konsumen. Rumah Burger merupakan salah satu usaha yang memiliki produk burger yang unik. Usaha ini mengalami perkembangan yang sangat pesat. Unsur keunikan produk yang dapat mempengaruhi terciptanya word of mouth adalah b...

  5. Ze luisteren gewillig en vinden het prachtig. Maar ik roep dit al jaren. Onderzoek naar bewonersbijeenkomsten en de relatie tussen burgers en gemeente in Almere

    Bleijenberg, Christine; Dessing, Nick; Renes, Reint Jan

    2013-01-01

    Burgerparticipatie en interactieve beleidsontwikkeling zijn niet meer weg te denken uit de manier van werken van Nederlandse gemeenten (WRR, 2012). Bewonersbijeenkomsten zijn hierbij, ondanks alle online mogelijkheden, een bekende en frequent toegepaste methode voor interactie tussen gemeente en burgers. Bestuurskundig onderzoek naar burgerparticipatie richt zich vaak op de tevredenheid van burgers en overheid met de resultaten, de samenwerking, de vorm en het democratisch gehalte van project...

  6. Embedded adhesive connection for laminated glass plates

    Hansen, Jens Zangenberg; Poulsen, S.H.; Bagger, A.; Stang, Henrik; Olesen, John Forbes

    2012-01-01

    The structural behavior of a new connection design, the embedded adhesive connection, used for laminated glass plates is investigated. The connection consists of an aluminum plate encapsulated in-between two adjacent triple layered laminated glass plates. Fastening between glass and aluminum is...... ensured using a structural adhesive. At first, the elastic and viscoelastic material properties of the adhesive are identified where the influence of load-rate and failure properties are also examined. Through an inverse analysis using the finite element method, the experimental observations are...... replicated to identify a material model of the adhesive. The material model consists of an elastic and linear viscoelastic formulation suitable for a numerical implementation of the material. Based on two relevant load cases, out-of-plane bending and in-plane shear, the connection performance is investigated...

  7. A new domain decomposition algorithm for generalized Burger's-Huxley equation based on Chebyshev polynomials and preconditioning

    In this study, we use the spectral collocation method using Chebyshev polynomials for spatial derivatives and fourth order Runge-Kutta method for time integration to solve the generalized Burger's-Huxley equation (GBHE). To reduce round-off error in spectral collocation (pseudospectral) method we use preconditioning. Firstly, theory of application of Chebyshev spectral collocation method with preconditioning (CSCMP) and domain decomposition on the generalized Burger's-Huxley equation presented. This method yields a system of ordinary differential algebric equations (DAEs). Secondly, we use fourth order Runge-Kutta formula for the numerical integration of the system of DAEs. The numerical results obtained by this way have been compared with the exact solution to show the efficiency of the method.

  8. Self-similar solutions for some nonlinear evolution equations: KdV, mKdV and Burgers equations

    S.A. El-Wakil

    2016-02-01

    Full Text Available A method for solving three types of nonlinear evolution equations namely KdV, modified KdV and Burgers equations, with self-similar solutions is presented. The method employs ideas from symmetry reduction to space and time variables and similarity reductions for nonlinear evolution equations are performed. The obtained self-similar solutions of KdV and mKdV equations are related to Bessel and Airy functions whereas those of Burgers equation are related to the error and Hermite functions. These solutions appear as new types of solitary, shock and periodic waves. Also, the method can be applied to other nonlinear evolution equations in mathematical physics.

  9. Particle diameter influences adhesion under flow.

    Shinde Patil, V R; Campbell, C. J.; Yun, Y.H.; Slack, S M; Goetz, D J

    2001-01-01

    The diameter of circulating cells that may adhere to the vascular endothelium spans an order of magnitude from approximately 2 microm (e.g., platelets) to approximately 20 microm (e.g., a metastatic cell). Although mathematical models indicate that the adhesion exhibited by a cell will be a function of cell diameter, there have been few experimental investigations into the role of cell diameter in adhesion. Thus, in this study, we coated 5-, 10-, 15-, and 20-microm-diameter microspheres with ...

  10. Solid-liquid work of adhesion of coarse-grained models of n-hexane on graphene layers derived from the conditional reversible work method

    Ardham, Vikram Reddy; Leroy, Frédéric, E-mail: vandervegt@csi.tu-darmstadt.de, E-mail: f.leroy@theo.chemie.tu-darmstadt.de [Eduard-Zintl-Institut für Anorganische und Physikalische Chemie, Technische Universität Darmstadt, Alarich-Weiss-Strasse 4, 64287 Darmstadt (Germany); Deichmann, Gregor; Vegt, Nico F. A. van der, E-mail: vandervegt@csi.tu-darmstadt.de, E-mail: f.leroy@theo.chemie.tu-darmstadt.de [Center of Smart Interfaces, Technische Universität Darmstadt, Alarich-Weiss-Strasse 10, 64287 Darmstadt (Germany)

    2015-12-28

    We address the question of how reducing the number of degrees of freedom modifies the interfacial thermodynamic properties of heterogeneous solid-liquid systems. We consider the example of n-hexane interacting with multi-layer graphene which we model both with fully atomistic and coarse-grained (CG) models. The CG models are obtained by means of the conditional reversible work (CRW) method. The interfacial thermodynamics of these models is characterized by the solid-liquid work of adhesion W{sub SL} calculated by means of the dry-surface methodology through molecular dynamics simulations. We find that the CRW potentials lead to values of W{sub SL} that are larger than the atomistic ones. Clear understanding of the relationship between the structure of n-hexane in the vicinity of the surface and W{sub SL} is elucidated through a detailed study of the energy and entropy components of W{sub SL}. We highlight the crucial role played by the solid-liquid energy fluctuations. Our approach suggests that CG potentials should be designed in such a way that they preserve the range of solid-liquid interaction energies, but also their fluctuations in order to preserve the reference atomistic value of W{sub SL}. Our study thus opens perspectives into deriving CG interaction potentials that preserve the thermodynamics of solid-liquid contacts and will find application in studies that intend to address materials driven by interfaces.

  11. Solid-liquid work of adhesion of coarse-grained models of n-hexane on graphene layers derived from the conditional reversible work method

    We address the question of how reducing the number of degrees of freedom modifies the interfacial thermodynamic properties of heterogeneous solid-liquid systems. We consider the example of n-hexane interacting with multi-layer graphene which we model both with fully atomistic and coarse-grained (CG) models. The CG models are obtained by means of the conditional reversible work (CRW) method. The interfacial thermodynamics of these models is characterized by the solid-liquid work of adhesion WSL calculated by means of the dry-surface methodology through molecular dynamics simulations. We find that the CRW potentials lead to values of WSL that are larger than the atomistic ones. Clear understanding of the relationship between the structure of n-hexane in the vicinity of the surface and WSL is elucidated through a detailed study of the energy and entropy components of WSL. We highlight the crucial role played by the solid-liquid energy fluctuations. Our approach suggests that CG potentials should be designed in such a way that they preserve the range of solid-liquid interaction energies, but also their fluctuations in order to preserve the reference atomistic value of WSL. Our study thus opens perspectives into deriving CG interaction potentials that preserve the thermodynamics of solid-liquid contacts and will find application in studies that intend to address materials driven by interfaces

  12. Handbook of adhesion

    Packham, D E

    2006-01-01

    This second edition of the successful Handbook of Adhesion provides concise and authoritative articles covering many aspects of the science and technology associated with adhesion and adhesives. It is intended to fill a gap between the necessarily simplified treatment of the student textbook and the full and thorough treatment of the research monograph and review article. The articles are structured in such a way, with internal cross-referencing and external literature references, that the reader can build up a broader and deeper understanding, as their needs require.This second edition includ

  13. Variable Separation Approach to Solve (2 + 1)-Dimensional Generalized Burgers System:Solitary Wave and Jacobi Periodic Wave Excitations

    ZHENG Chun-Long

    2004-01-01

    By means of the standard truncated Painleve expansion and a variable separation approach, a general variable separation solution of the generalized Burgers system is derived. In addition to the usual localized coherent soliton excitations like dromions, lumps, rings, breathers, instantons, oscillating soliton excitations, peakons, foldons,and previously revealed chaotic and fractal localized solutions, some new types of excitations - compacton and Jacobi periodic wave solutions are obtained by introducing appropriate lower dimensional piecewise smooth functions and Jacobi elliptic functions.

  14. Surface perturbations of a shallow viscous fluid heated from below and the (2+1)-dimensional Burgers equation

    The (2+1)-dimensional Burgers equation is obtained as the equation of motion governing the surface perturbations of a shallow viscous fluid heated from below, provided the Rayleigh number of the system satisfy the condition R ≠ 30. A solution to this equation is explicity exhibited and it is argued that it describes the nonlinear evolution of a nearly one-dimensional kink. (author)

  15. Influence of natural antioxidants on lipid composition of beef burgers submitted to irradiation in 60 Co source and electron beams

    Radiation processing has been employed in some countries as a mean of treatment to assure microbiological safety of meat and meat products, avoiding the occurrence of food-borne disease. The ionizing radiation may cause some undesirable changes on chemistry composition of food and the lipid oxidation is one of the main reactions. In meat products processing industry, the lipid composition is directly related to nutritional and sensory quality of the product. For preventing oxidation, use of antioxidants which can be synthetic or natural, has been practically applied in some products. Currently, most attention has been given to natural antioxidants from herbs and spices like rosemary and oregano. The aim this study was to assess the antioxidant effects of either rosemary and oregano extract in beef burgers submitted to irradiation in 60Co source with dose 6, 7 e 8 kGy, electron beams with dose 3,5 e 7 kGy and storage under freeze along 0, 45 e 90 days. The results showed that rosemary extract has the major antioxidant effects when it is used on heterogeneous food matrix like beef burger, but oregano extract was better efficient to delay lipid oxidation along storage time when it is used in synergism with rosemary and/or BHT/BHA. Although to have occurred changes in the fatty acids composition it was not possible to demonstrate a straight dependence of irradiation dose and/or storage time. Sensory analysis showed that between the samples prepared with natural antioxidants, the beef burger prepared with oregano has received better scores by panelists. Irradiated beef burger prepared with rosemary has received better scores when compared to non-irradiated one. The use of spices with antioxidant activity to avoid the oxidative damage in foods that contain fats in their formulation is thought to be promising to application in food facilities. (author)

  16. Solar vision Amsterdam. Citizens and businesses go for the sun; Zonvisie Amsterdam. Burgers en bedrijven gaan voor de zon

    Stam, T.; Diependaal, F.; Van ' t Hull, C.

    2013-06-15

    In the Solar Vision it is explained how the Amsterdam municipality plans to enable its citizens and businesses to realize their own solar energy project. The Solar Vision is prepared based on input from residents, businesses and institutions [Dutch] In de zonvisie staat hoe de gemeente Amsterdam haar burgers en bedrijven in staat wil stellen om hun eigen zonne-energieproject te realiseren. De zonvisie is mede opgesteld op basis van input van bewoners, bedrijven en instellingen.

  17. The Lie algebra of invariant group of the KdV, MKdV, or Burgers equation

    In this paper it is proved that all generators of the invariant group of the KdV, MKdV or Burgers equation form a commutative Lie algebra, from which it follows that for any symmetry of these three equations, the evolution equation possesses an infinite number of symmetries (or conservation laws in the case of KdV and MKdV equations). The authors conjecture that this result holds for a yet wider class of equations. (Auth.)

  18. FINITE ELEMENT ANALYSIS OF WOOD ADHESIVE JOINTS

    Thomas GEREKE

    2016-03-01

    Full Text Available Engineered wood products such as glulam or cross-laminated timber are widely established in the construction industry. Their structural behaviour and reliability clearly bases on the adhesive bonding. In order to understand and improve the performance of glued wood members a finite element modelling of standard single lap shear samples was carried out. A three-dimensional model of a longitudinal tensile-shear specimen with quasi-centric load application was developed. The main influences of wood and adhesive parameters on structural performance were identified. Therefore, variations of the elasticity, the annual ring angle, fibre angle, and the interface zone and their effect on the occurring stresses in the adhesive bond line were investigated numerically. The adhesive bond line is most significantly sensitive to the Young´s modulus of the adhesive itself. A variation of the fibre angle of the glued members in the standard test is an essential criterion and to be considered when preparing lap shear specimens. A model with representation of early- and latewood gives a more detailed insight into wooden adhesive joints.

  19. Mediterranean Berries as Inhibitors of Lipid Oxidation in Porcine Burger Patties Subjected to Cooking and Chilled Storage

    Rui Ganho; Mario Estvez; Mnica Armenteros; David Morcuende

    2013-01-01

    The efifciency of extracts from Arbutus unedo L. (AU), Crataegus monogyna L. (CM), Rosa canina L. (RC), and Rubus ulmifolius Schott. (RU) to inhibit lipid oxidation in raw, cooked and cooked and chilled (2°C/12 d) porcine burger patties, was investigated. The modiifcation of the fatty acid proifle during processing treatments (cooking and chilling), the quantitative measurements of thiobarbituric acid reactive substances (TBA-RS), and lipid-derived volatiles, were used as indicators of lipid oxidation. Polyunsaturated fatty acids (PUFA) gradually decreased during cooking and the subsequent storage of cooked burger patties with this decrease being signiifcantly greater (P<0.05) in control patties than in those with added berry extracts. In accordance, the control patties showed signiifcantly higher TBA-RS numbers and counts of lipid-derived volatiles in all treatments when compared to the berry-added counterparts (P<0.05). Results from the present work show, for the ifrst time, that extracts from A. unedo, C. monogyna, R. canina, and R. ulmifolius are promising antioxidants which could enhance the nutritional, safety and sensory properties of porcine burger patties.

  20. Isolation and biochemical characterization of underwater adhesives from diatoms.

    Poulsen, Nicole; Kröger, Nils; Harrington, Matthew J; Brunner, Eike; Paasch, Silvia; Buhmann, Matthias T

    2014-01-01

    Many aquatic organisms are able to colonize surfaces through the secretion of underwater adhesives. Diatoms are unicellular algae that have the capability to colonize any natural and man-made submerged surfaces. There is great technological interest in both mimicking and preventing diatom adhesion, yet the biomolecules responsible have so far remained unidentified. A new method for the isolation of diatom adhesive material is described and its amino acid and carbohydrate composition determined. The adhesive materials from two model diatoms show differences in their amino acid and carbohydrate compositions, but also share characteristic features including a high content of uronic acids, the predominance of hydrophilic amino acid residues, and the presence of 3,4-dihydroxyproline, an extremely rare amino acid. Proteins containing dihydroxyphenylalanine, which mediate underwater adhesion of mussels, are absent. The data on the composition of diatom adhesives are consistent with an adhesion mechanism based on complex coacervation of polyelectrolyte-like biomolecules. PMID:24689803

  1. Adhesion of Lunar Dust

    Walton, Otis R.

    2007-04-01

    This paper reviews the physical characteristics of lunar dust and the effects of various fundamental forces acting on dust particles on surfaces in a lunar environment. There are transport forces and adhesion forces after contact. Mechanical forces (i.e., from rover wheels, astronaut boots and rocket engine blast) and static electric effects (from UV photo-ionization and/or tribo-electric charging) are likely to be the major contributors to the transport of dust particles. If fine regolith particles are deposited on a surface, then surface energy-related (e.g., van der Walls) adhesion forces and static-electric-image forces are likely to be the strongest contributors to adhesion. Some measurement techniques are offered to quantify the strength of adhesion forces. And finally some dust removal techniques are discussed.

  2. Leukocyte Adhesion Deficiency (LAD)

    ... Content Marketing Share this: Main Content Area Leukocyte Adhesion Deficiency (LAD) LAD is an immune deficiency in ... are slow to heal also may have LAD. Treatment and Research Doctors prescribe antibiotics to prevent and ...

  3. Management of adhesive capsulitis

    Neviaser, Andrew

    2015-01-01

    Kristen L Stupay,1 Andrew S Neviaser2 1Tulane University School of Medicine, New Orleans, LA, USA; 2George Washington University Medical Faculty Associates, Washington, DC, USA Abstract: Adhesive capsulitis of the shoulder is a condition of capsular contracture that reduces both active and passive glenohumeral motion. The cause of adhesive capsulitis is not known but it is strongly associated with endocrine abnormalities such as diabetes. Diverse terminology and the absence of definitive cri...

  4. Nanorough titanium surfaces reduce adhesion of Escherichia coli and Staphylococcus aureus via nano adhesion points.

    Lüdecke, Claudia; Roth, Martin; Yu, Wenqi; Horn, Uwe; Bossert, Jörg; Jandt, Klaus D

    2016-09-01

    Microbial adhesion to natural and synthetic materials surfaces is a key issue e.g. in food industry, sewage treatment and most importantly in the biomedical field. The current development and progress in nanoscale structuring of materials surfaces to control microbial adhesion requires an advanced understanding of the microbe-material-interaction. This study aimed to investigate the nanostructure of the microbe-material-interface and link it to microbial adhesion kinetics as function of titanium surface nanoroughness to gain new insight into controlling microbial adhesion via materials' surface nanoroughness. Adhesion of Escherichia coli and Staphylococcus aureus was statistically significantly reduced (p≤0.05) by 55.6 % and 40.5 %, respectively, on physical vapor deposited titanium thin films with a nanoroughness of 6nm and the lowest surface peak density compared to 2nm with the highest surface peak density. Cross-sectioning of the microbial cells with a focused ion beam (FIB) and SEM imaging provided for the first time direct insight into the titanium-microbe-interface. High resolution SEM micrographs gave evidence that the surface peaks are the loci of initial contact between the microbial cells and the material's surface. In a qualitative model we propose that the initial microbial adhesion on nanorough surfaces is controlled by the titanium surface peak density via nano adhesion points. This new understanding will help towards the design of materials surfaces for controlling microbial adhesion. PMID:27288816

  5. Preventive effect of carboxymethyl chitosan solution on postoperative peritoneal adhesions in a rat model%羧甲基壳聚糖冲洗液预防大鼠术后腹膜粘连

    崔娟娟; 冯占芹; 张守强; 郑增娟; 张维芬

    2014-01-01

    背景:开腹手术后常造成腹膜粘连,给患者带来极大的痛苦,至今仍没有发现一种有效的药物或方法能够完全预防腹膜粘连,羧甲基壳聚糖是具有优良生物相容性和生物降解性,是理想的预防腹腔粘连的生物材料。目的:研究羧甲基壳聚糖防粘连冲洗液预防大鼠术后腹膜粘连的效果,探讨其防粘连的作用机制。  方法:取56只成年雄性Wistar大鼠建立盲肠刮伤/腹壁缺损的动物手术模型,随机分为4组,分别以生理盐水、医用透明质酸、医用几丁糖和羧甲基壳聚糖防粘连冲洗液涂布于盲肠刮伤面及腹壁缺损处。术后2,3周进行粘连分级和病理组织观察,同时测定转化生长因子β1表达、血液中白细胞数量及羟脯氨酸含量。  结果与结论:透明质酸组、几丁糖组粘连分级评分结果优于生理盐水组(P OBJECTIVE:To investigate the novel anti-adhesion properties of carboxymethyl chitosan anti-adhesion solution on the prevention of postsurgical adhesion in vivo in a rat model. METHODS:Fifty-six adult male Wistar rats were randomly divided into four groups: 0.9% normal saline solution (group A), hyaluronic acid gels (group B), medical chitosan gels (group C) and carboxymethyl chitosan anti-adhesion solution (group D). The model of postoperative intestinal adhesion was established by making cecal scratches/abdominal wal defects. Al the rats were scarified after 2 or 3 weeks. Whole blood was colected by cardio-puncture, lung tissue and tissue adhesion were stripped. The incidence and degree of adhesions, histological effects, expression of transforming growth factor-β1 (TGF-β1), the amounts of hydroxyproline and white blood cels were observed. RESULTS AND CONCLUSION:The formation of postsurgical adhesions in groups B, C and D was significantly decreased, which was lighter than that of group A (P < 0.05). Furthermore, the adhesion formation in group D was

  6. Airway Hyperresponsiveness in Asthma Model Occurs Independently of Secretion of β1 Integrins in Airway Wall and Focal Adhesions Proteins Down Regulation.

    Álvarez-Santos, Mayra; Carbajal, Verónica; Tellez-Jiménez, Olivia; Martínez-Cordero, Erasmo; Ruiz, Victor; Hernández-Pando, Rogelio; Lascurain, Ricardo; Santibañez-Salgado, Alfredo; Bazan-Perkins, Blanca

    2016-10-01

    The extracellular domains of some membrane proteins can be shed from the cell. A similar phenomenon occurs with β1 integrins (α1β1 and α2β1) in guinea pig. The putative role of β1 integrin subunit alterations due to shedding in airway smooth muscle (ASM) in an allergic asthma model was evaluated. Guinea pigs were sensitized and challenged with antigen. Antigenic challenges induced bronchoobstruction and hyperresponsiveness at the third antigenic challenge. Immunohistochemistry and immunoelectronmicroscopy studies showed that the cytosolic and extracellular domains of the β1 integrin subunit shared the same distribution in airway structures in both groups. Various polypeptides with similar molecular weights were detected with both the cytosolic and extracellular β1 integrin subunit antibodies in isolated airway myocytes and the connective tissue that surrounds the ASM bundle. Flow cytometry and Western blot studies showed that the expression of cytosolic and extracellular β1 integrin subunit domains in ASM was similar between groups. An increment of ITGB1 mRNA in ASM was observed in the asthma model group. RACE-PCR of ITGB1 in ASM did not show splicing variants. The expression levels of integrin-linked kinase (ILK) and paxillin diminished in the asthma model, but not talin. The levels of phosphorylation of myosin phosphatase target subunit 1 (MYPT1) at Thr(696) increased in asthma model. Our work suggests that β1 integrin is secreted in guinea pig airway wall. This secretion is not altered in asthma model; nevertheless, β1 integrin cytodomain assembly proteins in focal cell adhesions in which ILK and paxillin are involved are altered in asthma model. J. Cell. Biochem. 117: 2385-2396, 2016. © 2016 Wiley Periodicals, Inc. PMID:26969873

  7. Fourth-order compact schemes for the numerical simulation of coupled Burgers' equation

    Bhatt, H. P.; Khaliq, A. Q. M.

    2016-03-01

    This paper introduces two new modified fourth-order exponential time differencing Runge-Kutta (ETDRK) schemes in combination with a global fourth-order compact finite difference scheme (in space) for direct integration of nonlinear coupled viscous Burgers' equations in their original form without using any transformations or linearization techniques. One scheme is a modification of the Cox and Matthews ETDRK4 scheme based on (1 , 3) -Padé approximation and other is a modification of Krogstad's ETDRK4-B scheme based on (2 , 2) -Padé approximation. Efficient versions of the proposed schemes are obtained by using a partial fraction splitting technique of rational functions. The stability properties of the proposed schemes are studied by plotting the stability regions, which provide an explanation of their behavior for dispersive and dissipative problems. The order of convergence of the schemes is examined empirically and found that the modification of ETDRK4 converges with the expected rate even if the initial data are nonsmooth. On the other hand, modification of ETDRK4-B suffers with order reduction if the initial data are nonsmooth. Several numerical experiments are carried out in order to demonstrate the performance and adaptability of the proposed schemes. The numerical results indicate that the proposed schemes provide better accuracy than other schemes available in the literature. Moreover, the results show that the modification of ETDRK4 is reliable and yields more accurate results than modification of ETDRK4-B, while solving problems with nonsmooth data or with high Reynolds number.

  8. Influence of Discrete Sources on Detonation Propagation in a Burgers Equation Analog System

    Mi, XiaoCheng

    2015-01-01

    An analog to the equations of compressible flow that is based on the inviscid Burgers equation is utilized to investigate the effect of spatial discreteness of energy release on the propagation of a detonation wave. While the traditional Chapman-Jouguet (CJ) treatment of a detonation wave assumes that the energy release of the medium is homogeneous through space, the system examined here consists of sources represented by $\\delta$-functions embedded in an otherwise inert medium. The sources are triggered by the passage of the leading shock wave following a delay that is either of fixed period or randomly generated. The solution for wave propagation through a large array ($10^3$-$10^4$) of sources in one dimension can be constructed without the use of a finite difference approximation by tracking the interaction of sawtooth-profiled waves for which an analytic solution is available. A detonation-like wave results from the interaction of the shock and rarefaction waves generated by the sources. The measurement ...

  9. Influence of discrete sources on detonation propagation in a Burgers equation analog system

    Mi, XiaoCheng; Higgins, Andrew J.

    2015-05-01

    An analog to the equations of compressible flow that is based on the inviscid Burgers equation is utilized to investigate the effect of spatial discreteness of energy release on the propagation of a detonation wave. While the traditional Chapman-Jouguet (CJ) treatment of a detonation wave assumes that the energy release of the medium is homogeneous through space, the system examined here consists of sources represented by δ functions embedded in an otherwise inert medium. The sources are triggered by the passage of the leading shock wave following a delay that is either of fixed period or randomly generated. The solution for wave propagation through a large array (103-104) of sources in one dimension can be constructed without the use of a finite difference approximation by tracking the interaction of sawtooth-profiled waves for which an analytic solution is available. A detonation-like wave results from the interaction of the shock and rarefaction waves generated by the sources. The measurement of the average velocity of the leading shock front for systems of both regular, fixed-period and randomized sources is found to be in close agreement with the velocity of the equivalent CJ detonation in a uniform medium, wherein the sources have been spatially homogenized. This result may have implications for the applicability of the CJ criterion to detonations in highly heterogeneous media (e.g., polycrystalline, solid explosives) and unstable detonations with a transient and multidimensional structure (e.g., gaseous detonation waves).

  10. Wavelet methods to eliminate resonances in the Galerkin-truncated Burgers and Euler equations

    Pereira, Rodrigo M; Farge, Marie; Schneider, Kai

    2013-01-01

    It is well known that solutions to the Fourier-Galerkin truncation of the inviscid Burgers equation (and other hyperbolic conservation laws) do not converge to the physically relevant entropy solution after the formation of the first shock. This loss of convergence was recently studied in detail in [S. S. Ray et al., Phys. Rev. E 84, 016301 (2011)], and traced back to the appearance of a spatially localized resonance phenomenon perturbing the solution. In this work, we propose a way to remove this resonance by filtering a wavelet representation of the Galerkin-truncated equations. A method previously developed with a complex-valued wavelet frame is applied and expanded to embrace the use of real-valued orthogonal wavelet basis, which we show to yield satisfactory results only under the condition of adding a safety zone in wavelet space. We also apply the complex-valued wavelet based method to the 2D Euler equation problem, showing that it is able to filter the resonances in this case as well.

  11. Exponentially slow traveling waves on a finite interval for Burgers' type equation

    Pieter De Groen

    1998-11-01

    Full Text Available In this paper we study for small positive $epsilon$ the slow motion of the solution for evolution equations of Burgers' type with small diffusion, $$ u_t=epsilon u_{xx}+f(u,u_x,, quad u(x,0=u_0(x, quad u(pm 1,t=pm 1, $$ on the bounded spatial domain $[-1,1]$; $f$ is a smooth function satisfying $f(1>0, f(-1<0$ and $int_{-1}^{1}f(tdt=0$. The initial and boundary value problem~($star$ has a unique asymptotically stable equilibrium solution that attracts all solutions starting with continuous initial data $u_0$. On the infinite spatial domain ${mathbb R}$ the differential equation has slow speed traveling wave solutions generated by profiles that satisfy the boundary conditions of~($star$. As long as its zero stays inside the interval $[-1,1]$, such a traveling wave suitably describes the slow long term behaviour of the solution of ($star$ and its speed characterizes the local velocity of the slow motion with exponential precision. A solution that starts near a traveling wave moves in a small neighborhood of the traveling wave with exponentially slow velocity (measured as the speed of the unique zero during an exponentially long time interval $(0,T$. In this paper we give a unified treatment of the problem, using both Hilbert space and maximum principle methods, and we give rigorous proofs of convergence of the solution and of the asymptotic estimate of the velocity.

  12. Computational Modeling Reveals that a Combination of Chemotaxis and Differential Adhesion Leads to Robust Cell Sorting during Tissue Patterning

    Tan, Rui Zhen; Chiam, Keng-Hwee

    2014-01-01

    Robust tissue patterning is crucial to many processes during development. The "French Flag" model of patterning, whereby naïve cells in a gradient of diffusible morphogen signal adopt different fates due to exposure to different amounts of morphogen concentration, has been the most widely proposed model for tissue patterning. However, recently, using time-lapse experiments, cell sorting has been found to be an alternative model for tissue patterning in the zebrafish neural tube. But it remain...

  13. 应用于爬壁机器人的静电吸附原理建模及关键因素分析%Principle modeling and key factors analysis of the electrostatic adhesion mechanism used in wall climbing robot

    王黎明; 胡青春

    2012-01-01

    This paper includes an illustration of the electrostatic adhesion mechanism which is applied in the parti cular area of wall climbing robots. The adhesion mechanism of electrostatic adhesion technology will be researched at the beginning, then, the theoretical attraction force model between the electrodes and wall is built. Through the principle of virtual work, the paper obtains a mathematical expression of electrostatic adhesion, and for more com plexity, makes a specific investigation of double electrodes type, which is the base of comb-shaped electrodes. Schwarz-Christoffel transform will be utilized in this part, and it is an effective method in dealing with non-uniform electric field. Next, Matlab software is used to analyze the key factors which affect the adsorption strength in the e lectrodes. To illustrate the problem further, a simulation of voltage between the electrodes is done. Finally, to veri fy this adhesive function, an experiment with comb-shaped electrodes is done, from which it can be concluded that electrostatic adhesion can be a large attraction power in wall-climbing robots application.%本文对应用于静电吸附式爬壁机器人这一特殊领域的静电吸附原理进行分析,对静电力进行数学解析建模,通过施瓦兹-克里斯托菲数学变换重点分析影响梳状电极吸附力的结构因素,并借助Ansoft软件求解出不同占空比下的电极电容矩阵,最后通对设计的柔性板梳状电极进行实际实验测试,验证静电吸附在爬壁机器人应用上的可靠性.

  14. ING-1(heMAb, a Monoclonal Antibody to Epithelial Cell Adhesion Molecule, Inhibits Tumor Metastases in a Murine Cancer Model

    Harry H. Ruan

    2003-11-01

    Full Text Available ING-1(heMAb, a human-engineered monoclonal antibody (MAb that specifically targets the epithelial cell adhesion molecule (Ep-CAM, kills adenocarcinoma cells in vitro and inhibits tumor growth in vivo. In the current study, we evaluated the efficacy of ING-1(heMAb in a murine model of cancer metastases. Mice received intravenous dosing of 1 mg/kg ING-1(heMAb, twice a week, starting on day 2 or day 5. A negative control group received 1 mg/kg human immunoglobulin G with the same dose frequency starting on day 2. A positive control group received weekly 100 mg/kg 54lurouracil/leucovorin starting on day 2. ING-1(heMAb/day 2 treatment significantly reduced both the number of visible tumor nodules in body cavities (P < .01 and the number of metastases on lung surfaces (P < .005. The treatment also resulted in a 91% reduction of micrometastases in lung tissues (P <.0001. Delaying ING-1(heMAb treatment until day 5 caused 54% reduction in micrometastases (P <.005. Our results indicate that a number of parameters, including treatment starting day, dose level, and dose frequency, are critical in achieving the optimal efficacy of ING-1(heMAb. We conclude that ING-1(heMAb effectively reduced tumor metastases in a murine cancer model. Immunotherapy with ING-1(heMAb may be beneficial in treating human metastatic diseases.

  15. Dual-axis MEMS force sensors for gecko adhesion studies

    Hill, Ginel Corina

    Dual-axis piezoresistive microelectromechanical systems (MEMS) force sensors were used to investigate the effects of orientation angle on the adhesion of gecko hairs, called setae. These hairs are part of a fantastic, robust dry adhesive. Their adhesion is highly angle-dependent, with both the "pitch" and "roll" orientation angles playing a role. This anisotropy in adhesion properties is critical for locomotion, as it enables detachment of the gecko's foot with limited pull-off force. Many synthetic mimics of the gecko adhesive are isotropic. This work on the anisotropy of natural setae will inform future work on synthetic dry adhesives. A dual-axis microscale force sensor was needed to study single seta adhesive forces, which are stronger parallel to a substrate than perpendicular. Piezoresistive silicon cantilevers that separately detect lateral and normal forces applied at the tip were used. The fabrication process and rigorous characterization of new devices are reported. A novel calibration method was developed that uses resonant frequency measurements in concert with finite element models to correct for the expected variability of critical dimensions. These corrected models were used to predict the stiffnesses of each cantilever, and thus improve the accuracy of force measurements made with these sensors. This calibration technique was also validated by direct measurement of the dual-axis cantilever stiffnesses using a reference cantilever. The adhesion force of a single gecko seta is dramatically enhanced by proper orientation. The dual-axis cantilevers were used to measure two components of force between a substrate and a Gekko gecko seta. Lateral adhesion was highest with the stalk oriented parallel to the surface at 0° pitch. Adhesion decreased smoothly as the pitch angle of the stalk was increased, until detachment or no adhesion occurred at approximately 30°. To display enhanced adhesion, the splayed tuft at the end of the seta needed to be only

  16. Dynamic force spectroscopy to probe adhesion strength of living cells

    Prechtel, K.; Bausch, A. R.; Marchi-Artzner, V.; Kantlehner, M.; Kessler, H; Merkel, R

    2002-01-01

    We studied the mechanical strength of the adhesion of living cells to model membranes. The latter contained a RGD lipopeptide which is a high affinity binding site for a cell adhesion molecule (integrin alpha(V)beta(3)). Cells adhered specifically to the vesicles. We used micropipette aspiration for breaking this adhesion with well defined forces. Systematic variation of the rate of force application revealed pronounced kinetic effects. The dependence of the detachment forces on the loading r...

  17. Multibody simulation of adhesion pili

    Zakrisson, Johan; Servin, Martin; Axner, Ove; Lacoursiere, Claude; Andersson, Magnus

    2014-01-01

    We present a coarse grained rigid multibody model of a subunit assembled helix-like polymer, e.g., adhesion pili expressed by bacteria, that is capable of describing the polymers force-extension response. With building blocks representing individual subunits the model appropriately describes the complex behavior of pili expressed by the gram-negative uropathogenic Escherichia coli bacteria under the action of an external force. Numerical simulations show that the dynamics of the model, which include both the effects of unwinding and rewinding, are in good quantitative agreement with the characteristic force-extension response as observed experimentally for type 1 and P pili. By tuning the model, it is also possible to reproduce the force-extension response in the presence of anti-shaft antibodies, which dramatically changes the mechanical properties. Thus, the model and the results in this work give enhanced understanding of how a pilus unwinds under action of external forces and provide new perspective of th...

  18. Detection of vascular cell adhesion molecule-1 expression with USPIO-enhanced molecular MRI in a mouse model of cerebral ischemia

    Vascular damage plays a critical role after stroke, leading notably to edema, hemorrhages and stroke recurrence. Tools to characterize the vascular lesion are thus a real medical need. In this context, the specific nano-particular contrast agent P03011, an USPIO (ultra-small superparamagnetic iron oxide) conjugated to a peptide that targets VCAM-1 (vascular cell adhesion molecule-1), was developed to detect this major component of the vascular inflammatory response. This study aimed to make the proof of concept of the capacity of this targeted USPIO to detect VCAM-1 with MRI after cerebral ischemia in mouse. The time course of VCAM-1 expression was first examined by immunohistochemistry in our model of cerebral ischemia-reperfusion. Secondly, P03011 or non-targeted USPIO P03007 were injected 5 h after ischemia (100 mmol iron kg-1; i.v.) and in vivo and ex vivo MRI were performed 24 h after ischemia onset. Double labeling immunofluorescence was then performed on brain slices in order to detect both USPIO and VCAM-1. VCAM-1 expression was significantly up-regulated 24 h after ischemia in our model. In animals receiving P03011, both in vivo and ex vivo MRI performed 24 h after ischemia onset showed hypointense foci which could correspond to iron particles. Histological analysis showed a co-localization of the targeted USPIO and VCAM-1. This study demonstrates that VCAM-1 detection is possible with the USPIO P03011 in a model of cerebral ischemia. This kind of contrast agent could be an interesting clinical tool to characterize ischemic lesions in terms of vascular damage. (authors)

  19. Adhesion of Neisseria meningitidis to Dermal Vessels Leads to Local Vascular Damage and Purpura in a Humanized Mouse Model

    Keira Melican; Paula Michea Veloso; Tiffany Martin; Patrick Bruneval; Guillaume Duménil

    2013-01-01

    Septic shock caused by Neisseria meningitidis is typically rapidly evolving and often fatal despite antibiotic therapy. Further understanding of the mechanisms underlying the disease is necessary to reduce fatality rates. Postmortem samples from the characteristic purpuric rashes of the infection show bacterial aggregates in close association with microvessel endothelium but the species specificity of N. meningitidis has previously hindered the development of an in vivo model to study the rol...

  20. Comment on "Application of the extended Lie group analysis to the Hopf functional formulation of the Burgers equation" [J. Math. Phys. 54, 072901 (2013)

    Frewer, Michael; Khujadze, George; Foysi, Holger

    2016-03-01

    The quest to find new statistical symmetries in the theory of turbulence is an ongoing research endeavor which is still in its beginning and exploratory stage. In our comment we show that the recently performed study of Wacławczyk and Oberlack [J. Math. Phys. 54, 072901 (2013)] failed to present such new statistical symmetries. Despite their existence within a functional Fourier space of the statistical Burgers equation, they all can be reduced to the classical and well-known symmetries of the underlying deterministic Burgers equation itself, except for one symmetry, but which, as we will demonstrate, is only a mathematical artefact without any physical meaning. Moreover, we show that the proposed connection between the translation invariance of the multi-point moments and a symmetry transformation associated to a certain invariant solution of the inviscid functional Burgers equation is invalid. In general, their study constructs and discusses new particular solutions of the functional Burgers equation without referring them to the well-established general solution. Finally, we also see a shortcoming in the presented methodology as being too restricted to construct a complete set of Lie point symmetries for functional equations. In particular, for the considered Burgers equation essential symmetries are not captured.

  1. Structural Evaluation of the RSRM Nozzle Replacement Adhesive

    Batista-Rodriguez, A.; McLennan, M. L.; Palumbos, A. V.; Richardson, D. E.

    1999-01-01

    This paper describes the structural performance evaluation of a replacement adhesive for the Reusable Solid Rocket Motor (RSRM) nozzle utilizing finite element analysis. Due to material obsolescence and industrial safety issues, the two current structural adhesives, EA 913 and EA 946 are to be replaced with a new adhesive. TIGA 321. The structural evaluation in support of the adhesive replacement effort includes residual stress, transportation, and flight analyses. Factors of safety are calculated using the stress response from each analysis. The factors of safety are used as the limiting criteria to compare the replacement adhesive against the current adhesives. Included in this paper are the analytical approach, assumptions and modeling techniques as well as the results of the evaluation. An important factor to the evaluation is the similarity in constitutive material properties (elastic modulus and Poisson's ratio) between TIGA 321 and EA 913. This similarity leads to equivalent material response from the two adhesives. However, TIGA 321 surpasses EA 913's performance due to higher material capabilities. Conversely, the change in stress response from EA 946 to TIGA 321 is more apparent: this is primarily attributed to the difference in the modulii of the two adhesives, which differ by two orders of magnitude. The results of the bondline evaluation indicate that the replacement adhesive provides superior performance than the current adhesives with only minor exceptions. Furthermore, TIGA 321 causes only a minor chance in the response of the phenolic and metal components.

  2. Towards a methodology for educational modelling: a case in educational assessment

    Giesbers, Bas; Van Bruggen, Jan; Hermans, Henry; Joosten-ten Brinke, Desirée; Burgers, Jan; Koper, Rob; Latour, Ignace

    2005-01-01

    Giesbers, B., van Bruggen, J., Hermans, H., Joosten-ten Brinke, D., Burgers, J., Koper, R., & Latour, I. (2007). Towards a methodology for educational modelling: a case in educational assessment. Educational Technology & Society, 10 (1), 237-247.

  3. Changes on lipid profile in beef burgers prepared with Rosemary extract and submitted to e-beam processing

    Radiation processing has been employed in some countries as a mean of treatment to assure microbiological safety of meat and meat products. Use of antioxidants for preventing lipid oxidation has been applied in those products. The present study aimed at evaluating the protecting effects of rosemary extract on the lipid profile of irradiated beef burgers. The samples were prepared with 400 ppm of rosemary extract, irradiated at doses 0, 3.5 and 7 kGy, stored at - 20 deg C for 45 days and after this time, evaluated in regard to the oxidative stability of lipids (TBARS values) and lipid profile in a GC (Gas chromatography). Non-irradiated and non-rosemary extract samples were used as a control. TBARS values were of 0.3 and 1.1 mgTBARS/kg of sample for rosemary extract and control samples (without extract) irradiated at 3.5 kGy, respectively. At 7 kGy, TBARS values were of 0.6 and 1.3 mgTBARS/kg of samples for rosemary extract and control samples (without extract), respectively. Total saturated fatty acid (SFA), monounsaturated fatty acid (MUFA) and polyunsaturated fatty acid (PUFA) did not change in beef burgers, although they showed small differences between the batches, this differences were not significant (P<0.05). The amounts of Trans fatty acid increased significantly (P<0.05) only when used irradiation dose of 7 kGy (0.86 g/100 g of sample). These results showed that the rosemary extract can avoid the developing of lipid oxidation and the irradiation processing did not change lipid profile in beef burgers. (author)

  4. Changes on lipid profile in beef burgers prepared with Rosemary extract and submitted to e-beam processing

    Trindade, Reginaldo A.; Sabundjian, Ingrid T.; Nunes, Thaise C.F.; Rogovschi, Vladimir D.; Villavicencio, Anna Lucia C.H. [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)]. E-mail: villavic@ipen.br; Mancini-Filho, Jorge [Universidade de Sao Paulo (USP), SP (Brazil). Faculdade de Ciencias Farmaceuticas. Lab. de Lipides]. E-mail: jmancini@usp.br

    2007-07-01

    Radiation processing has been employed in some countries as a mean of treatment to assure microbiological safety of meat and meat products. Use of antioxidants for preventing lipid oxidation has been applied in those products. The present study aimed at evaluating the protecting effects of rosemary extract on the lipid profile of irradiated beef burgers. The samples were prepared with 400 ppm of rosemary extract, irradiated at doses 0, 3.5 and 7 kGy, stored at - 20 deg C for 45 days and after this time, evaluated in regard to the oxidative stability of lipids (TBARS values) and lipid profile in a GC (Gas chromatography). Non-irradiated and non-rosemary extract samples were used as a control. TBARS values were of 0.3 and 1.1 mgTBARS/kg of sample for rosemary extract and control samples (without extract) irradiated at 3.5 kGy, respectively. At 7 kGy, TBARS values were of 0.6 and 1.3 mgTBARS/kg of samples for rosemary extract and control samples (without extract), respectively. Total saturated fatty acid (SFA), monounsaturated fatty acid (MUFA) and polyunsaturated fatty acid (PUFA) did not change in beef burgers, although they showed small differences between the batches, this differences were not significant (P<0.05). The amounts of Trans fatty acid increased significantly (P<0.05) only when used irradiation dose of 7 kGy (0.86 g/100 g of sample). These results showed that the rosemary extract can avoid the developing of lipid oxidation and the irradiation processing did not change lipid profile in beef burgers. (author)

  5. Switchable Adhesion in Vacuum Using Bio-Inspired Dry Adhesives.

    Purtov, Julia; Frensemeier, Mareike; Kroner, Elmar

    2015-11-01

    Suction based attachment systems for pick and place handling of fragile objects like glass plates or optical lenses are energy-consuming and noisy and fail at reduced air pressure, which is essential, e.g., in chemical and physical vapor deposition processes. Recently, an alternative approach toward reversible adhesion of sensitive objects based on bioinspired dry adhesive structures has emerged. There, the switching in adhesion is achieved by a reversible buckling of adhesive pillar structures. In this study, we demonstrate that these adhesives are capable of switching adhesion not only in ambient air conditions but also in vacuum. Our bioinspired patterned adhesive with an area of 1 cm(2) provided an adhesion force of 2.6 N ± 0.2 N in air, which was reduced to 1.9 N ± 0.2 N if measured in vacuum. Detachment was induced by buckling of the structures due to a high compressive preload and occurred, independent of air pressure, at approximately 0.9 N ± 0.1 N. The switch in adhesion was observed at a compressive preload between 5.6 and 6.0 N and was independent of air pressure. The difference between maximum adhesion force and adhesion force after buckling gives a reasonable window of operation for pick and place processes. High reversibility of the switching behavior is shown over 50 cycles in air and in vacuum, making the bioinspired switchable adhesive applicable for handling operations of fragile objects. PMID:26457864

  6. Sticking around: an up-close look at drop adhesion

    Paxson, Adam T

    2013-01-01

    We present a fluid dynamics video showing the adhesion of a drop to a superhydrophobic surface. We use environmental scanning electron microscopy to observe depinning events at the microscale. As the drop moves along the surface, the advancing portion of the contact line simply lies down onto the upcoming roughness features, contributing negligibly to adhesion. After measuring the local receding contact angle of capillary bridges formed on a micropillar array, we find that these depinning events follow the Gibbs depinning criterion. We further extend this technique to two-scale hierarchical structures to reveal a self-similar depinning mechanism in which the adhesion of the entire drop depends only on the pinning at the very smallest level of roughness hierarchy. With this self-similar depinning mechanism we develop a model to predict the adhesion of drops to superhydrophobic surfaces that explains both the low adhesion on sparsely structured surfaces and the surprisingly high adhesion on surfaces whose featu...

  7. Immunotherapeutic modulation of intraperitoneal adhesions by Asparagus racemosus.

    Rege N

    1989-10-01

    Full Text Available The hypothesis that macrophages appear to play a pivotal role in the development of intraperitoneal adhesions and that modulation of macrophage activity, therefore, is likely to provide a tool for prevention of adhesions, was tested in the present study. Effect of Asparagus racemosus, an indigenous agent with immunostimulant properties, was evaluated in an animal model of intraperitoneal adhesions induced by caecal rubbing. Animals were sacrificed 15 days following surgery. The peritoneal macrophages were collected to assess their activity. At the same time, peritoneal cavity was examined for the presence of adhesions, which were graded. A significant decrease was observed in the adhesion scores attained by animals receiving Asparagus racemosus. This was associated with significant increase in the activity of macrophages (70.1 +/- 2.52, compared to that in surgical controls (53.77 +/- 10.8. These findings support our hypothesis and provide a novel approach for the prevention and management of post-operative adhesions.

  8. Wood Composite Adhesives

    Gomez-Bueso, Jose; Haupt, Robert

    The global environment, in which phenolic resins are being used for wood composite manufacture, has changed significantly during the last decade. This chapter reviews trends that are driving the use and consumption of phenolic resins around the world. The review begins with recent data on volume usage and regional trends, followed by an analysis of factors affecting global markets. In a section on environmental factors, the impact of recent formaldehyde emission regulations is discussed. The section on economics introduces wood composite production as it relates to the available adhesive systems, with special emphasis on the technical requirement to improve phenolic reactivity. Advances in composite process technology are introduced, especially in regard to the increased demands the improvements place upon adhesive system performance. The specific requirements for the various wood composite families are considered in the context of adhesive performance needs. The results of research into current chemistries are discussed, with a review of recent findings regarding the mechanisms of phenolic condensation and acceleration. Also, the work regarding alternate natural materials, such as carbohydrates, lignins, tannins, and proteinaceous materials, is presented. Finally, new developments in alternative adhesive technologies are reported.

  9. Physical model of granule adhesion to the belt-electrodes of a tribo-aero-electrostatic separator

    Recent studies have demonstrated the effectiveness of tribo-aero-electrostatic separation technologies, which consist in the selective sorting of mixed granular insulating materials in a fluidized bed affected by an electric field orthogonally oriented to the direction of the fluidization air. The aim of the present paper is to put the theoretical bases for the optimization of this process, i. e. maximize the total mass of the granules collected at the two electrodes that generate the electric field. The various forces that drive a granule of given mass and electric charge through the electric field and make it stick to an electrode are expressed as functions of the several input variables and parameters of the process, such as the applied high-voltage or the surface roughness, the size and the position of the electrodes. The concepts of 'critical electrostatic field' and 'virtual climbing distance' are introduced. The prediction of the theoretical model are confirmed by the results of three sets of experiments, carried out on samples of a granular mixture consisting of 50% Acrylonitrile Butadiene Styrene (ABS) and 50% High Impact Polystyrene (HIPS), originating from the recycling of waste electric and electronic equipment. Higher separation efficiency was obtained when the electric field in the active zone was intensified by the use of an additional electrode connected to the ground and when the collecting electrodes were covered by a thin insulating layer.

  10. Coating Reduces Ice Adhesion

    Smith, Trent; Prince, Michael; DwWeese, Charles; Curtis, Leslie

    2008-01-01

    The Shuttle Ice Liberation Coating (SILC) has been developed to reduce the adhesion of ice to surfaces on the space shuttle. SILC, when coated on a surface (foam, metal, epoxy primer, polymer surfaces), will reduce the adhesion of ice by as much as 90 percent as compared to the corresponding uncoated surface. This innovation is a durable coating that can withstand several cycles of ice growth and removal without loss of anti-adhesion properties. SILC is made of a binder composed of varying weight percents of siloxane(s), ethyl alcohol, ethyl sulfate, isopropyl alcohol, and of fine-particle polytetrafluoroethylene (PTFE). The combination of these components produces a coating with significantly improved weathering characteristics over the siloxane system alone. In some cases, the coating will delay ice formation and can reduce the amount of ice formed. SILC is not an ice prevention coating, but the very high water contact angle (greater than 140 ) causes water to readily run off the surface. This coating was designed for use at temperatures near -170 F (-112 C). Ice adhesion tests performed at temperatures from -170 to 20 F (-112 to -7 C) show that SILC is a very effective ice release coating. SILC can be left as applied (opaque) or buffed off until the surface appears clear. Energy dispersive spectroscopy (EDS) and x-ray photoelectron spectroscopy (XPS) data show that the coating is still present after buffing to transparency. This means SILC can be used to prevent ice adhesion even when coating windows or other objects, or items that require transmission of optical light. Car windshields are kept cleaner and SILC effectively mitigates rain and snow under driving conditions.

  11. A design methodology for biologically inspired dry fibrillar adhesives

    Aksak, Burak

    Realization of the unique aspects of gecko adhesion and incorporating these aspects into a comprehensive design methodology is essential to enable fabrication of application oriented gecko-inspired dry fibrillar adhesives. To address the need for such a design methodology, we propose a fibrillar adhesion model that evaluates the effect of fiber dimensions and material on adhesive performance of fiber arrays. A fibrillar adhesion model is developed to predict the adhesive characteristics of an array of fibrillar structures, and quantify the effect of fiber length, radius, spacing, and material. Photolithography techniques were utilized to fabricate elastomer microfiber arrays. Fibers that are fabricated from stiff SU-8 photoresist are used to fabricate a flexible negative mold that facilitates fabrication of fiber arrays from various elastomers with high yield. The tips of the cylindrical fibers are modified to mushroom-like tip shapes. Adhesive strengths in excess of 100 kPa is obtained with mushroom tipped elastomer microfibers. Vertically aligned carbon nanofibers (VACNFs) are utilized as enhanced friction materials by partially embedding inside soft polyurethanes. Friction coefficients up to 1 were repeatedly obtained from the resulting VACNF composite structures. A novel fabrication method is used to attach Poly(n-butyl acrylate) (PBA) molecular brush-like structures on the surface of polydimethylsiloxane (PDMS). These brushes are grown on unstructured PDMS and PDMS fibers with mushroom tips. Pull-off force is enhanced by up to 7 times with PBA brush grafted micro-fiber arrays over unstructured PDMS substrate. Adhesion model, initially developed for curved smooth surfaces, is extended to self-affine fractal surfaces to better reflect the adhesion performance of fiber arrays on natural surfaces. Developed adhesion model for fiber arrays is used in an optimization scheme which estimates optimal design parameters to obtain maximum adhesive strength on a given

  12. Pathogenesis of postoperative adhesion formation

    Hellebrekers, B.W.J.; Kooistra, T.

    2011-01-01

    Background: Current views on the pathogenesis of adhesion formation are based on the "classical concept of adhesion formation", namely that a reduction in peritoneal fibrinolytic activity following peritoneal trauma is of key importance in adhesion development. Methods: A non-systematic literature s

  13. Fundamentals of adhesion of thermal spray coatings: Adhesion of single splats

    Indentation experiments were performed inside a scanning electron microscope to measure adhesive strength of individual alumina splats on a steel substrate. The in situ nature of experimental evaluations made characterization of interfacial crack propagation possible by direct observation. The increase in the strain energy of brittle alumina splats originating from indentation deformation was correlated to the strain energy release rate through the characterization of interfacial crack propagation. An analytical model previously reported and evaluated in studies of the adhesive strength of thin films was employed. An average calculated strain energy release rate of 80 J m-2 was found for single splats. This high value suggests that splat adhesion can make a significant contribution to the adhesion of thermal sprayed coatings.

  14. The Weighted Burgers Vector: a new quantity for constraining dislocation densities and types using electron backscatter diffraction on 2D sections through crystalline materials.

    Wheeler, J; Mariani, E; Piazolo, S; Prior, D J; Trimby, P; Drury, M R

    2009-03-01

    The Weighted Burgers Vector (WBV) is defined here as the sum, over all types of dislocations, of [(density of intersections of dislocation lines with a map) x (Burgers vector)]. Here we show that it can be calculated, for any crystal system, solely from orientation gradients in a map view, unlike the full dislocation density tensor, which requires gradients in the third dimension. No assumption is made about gradients in the third dimension and they may be non-zero. The only assumption involved is that elastic strains are small so the lattice distortion is entirely due to dislocations. Orientation gradients can be estimated from gridded orientation measurements obtained by EBSD mapping, so the WBV can be calculated as a vector field on an EBSD map. The magnitude of the WBV gives a lower bound on the magnitude of the dislocation density tensor when that magnitude is defined in a coordinate invariant way. The direction of the WBV can constrain the types of Burgers vectors of geometrically necessary dislocations present in the microstructure, most clearly when it is broken down in terms of lattice vectors. The WBV has three advantages over other measures of local lattice distortion: it is a vector and hence carries more information than a scalar quantity, it has an explicit mathematical link to the individual Burgers vectors of dislocations and, since it is derived via tensor calculus, it is not dependent on the map coordinate system. If a sub-grain wall is included in the WBV calculation, the magnitude of the WBV becomes dependent on the step size but its direction still carries information on the Burgers vectors in the wall. The net Burgers vector content of dislocations intersecting an area of a map can be simply calculated by an integration round the edge of that area, a method which is fast and complements point-by-point WBV calculations. PMID:19250469

  15. Ultrasonic Nondestructive Characterization of Adhesive Bonds

    Qu, Jianmin

    1999-01-01

    Adhesives and adhesive joints are widely used in various industrial applications to reduce weight and costs, and to increase reliability. For example, advances in aerospace technology have been made possible, in part, through the use of lightweight materials and weight-saving structural designs. Joints, in particular, have been and continue to be areas in which weight can be trimmed from an airframe through the use of novel attachment techniques. In order to save weight over traditional riveted designs, to avoid the introduction of stress concentrations associated with rivet holes, and to take full advantage of advanced composite materials, engineers and designers have been specifying an ever-increasing number of adhesively bonded joints for use on airframes. Nondestructive characterization for quality control and remaining life prediction has been a key enabling technology for the effective use of adhesive joints. Conventional linear ultrasonic techniques generally can only detect flaws (delamination, cracks, voids, etc) in the joint assembly. However, more important to structural reliability is the bond strength. Although strength, in principle, cannot be measured nondestructively, a slight change in material nonlinearity may indicate the onset of failure. Furthermore, microstructural variations due to aging or under-curing may also cause changes in the third order elastic constants, which are related to the ultrasonic nonlinear parameter of the polymer adhesive. It is therefore reasonable to anticipate a correlation between changes in the ultrasonic nonlinear acoustic parameter and the remaining bond strength. It has been observed that higher harmonics of the fundamental frequency are generated when an ultrasonic wave passes through a nonlinear material. It seems that such nonlinearity can be effectively used to characterize bond strength. Several theories have been developed to model this nonlinear effect. Based on a microscopic description of the nonlinear

  16. Characterization of selected wild Mediterranean fruits and comparative efficacy as inhibitors of oxidative reactions in emulsified raw pork burger patties.

    Ganhão, Rui; Estévez, Mario; Kylli, Petri; Heinonen, Marina; Morcuende, David

    2010-08-11

    In the present study, water, ethanolic, and methanolic extracts from seven selected wild fruits originally from the Mediterranean area, namely, strawberry tree ( Arbutus unedo L., AU), azarole ( Crataegus azarolus L., CA), common hawthorn ( Crataegus monogyna L., CM), blackthorn ( Prunus spinosa L., PS), dog rose ( Rosa canina L., RC), elm-leaf blackberry ( Rubus ulmifolius Schott, RU), and rowan ( Sorbus aucuparia L., SA), were analyzed for the total amount and profile of phenolic compounds and for the in vitro antioxidant activity against the DPPH and ABTS radicals (study 1). The seven fruits showed different chemical compositions, which consequently led to different antioxidant potentials. Among the seven fruits initially analyzed, AU, CM, RC, and RU had the highest amount of phenolic compounds and displayed the greatest antioxidant activity in vitro. Extracts from these four fruits were tested as inhibitors of lipid oxidation in raw pork burger patties subjected to refrigerated storage at 2 degrees C for 12 days (study 2). The quantitative measurements of thiobarbituric acid reactive substances (TBA-RS), hexanal content, and color stability were used as indicators of oxidative reactions. The four selected fruits displayed intense antioxidant activity against lipid oxidation, which highlights the potential usage of these fruits as ingredients for the manufacture of healthy meat products. Among them, RC and AU were particularly efficient as their protective effect against lipid oxidation was more intense than that displayed by quercetin (230 mg/kg of burger patty). PMID:20681673

  17. Direct Determination of Burgers Vectors of Threading Mixed Dislocations in 4H-SiC Grown by PVT Method

    Guo, Jianqiu; Yang, Yu; Wu, Fangzhen; Sumakeris, Joe; Leonard, Robert; Goue, Ouloide; Raghothamachar, Balaji; Dudley, Michael

    2016-04-01

    In addition to pure threading screw dislocations (TSDs), the presence of threading mixed dislocations (TMDs) (with a component) has been reported both in 4H-SiC axial slices (wafers cut parallel to the growth axis) and in commercial offcut wafers (cut almost perpendicular to the growth axis). In this paper, we first demonstrate a method to quickly distinguish TMDs from TSDs in axial slices via synchrotron white-beam x-ray topography. Since such axial slices are usually not available for commercial purposes, a systematic method is then developed and demonstrated here to unambiguously determine the Burgers vectors of TMDs in 4H-SiC commercial offcut wafers. In this second study, both synchrotron monochromatic-beam x-ray topography and ray-tracing simulation are used. The x-ray topographs were recorded using grazing-incidence geometry. The principle of this method is that the contrast of dislocations on different reflections varies with the relative orientation of Burgers vectors with respect to the diffraction vectors. Measurements confirm that, in a commercial offcut wafer, the majority of the threading dislocations with screw component are mixed-type dislocations.

  18. Biologically Inspired Mushroom-Shaped Adhesive Microstructures

    Heepe, Lars; Gorb, Stanislav N.

    2014-07-01

    Adhesion is a fundamental phenomenon with great importance in technology, in our everyday life, and in nature. In this article, we review physical interactions that resist the separation of two solids in contact. By using examples of biological attachment systems, we summarize and categorize various principles that contribute to the so-called gecko effect. Emphasis is placed on the contact geometry and in particular on the mushroom-shaped geometry, which is observed in long-term biological adhesive systems. Furthermore, we report on artificial model systems with this bio-inspired geometry and demonstrate that surface microstructures with this geometry are promising candidates for technical applications, in which repeatable, reversible, and residue-free adhesion under different environmental conditions—such as air, fluid, and vacuum—is required. Various applications in robotic systems and in industrial pick-and-place processes are discussed.

  19. Management of adhesive capsulitis

    Stupay KL

    2015-08-01

    Full Text Available Kristen L Stupay,1 Andrew S Neviaser2 1Tulane University School of Medicine, New Orleans, LA, USA; 2George Washington University Medical Faculty Associates, Washington, DC, USA Abstract: Adhesive capsulitis of the shoulder is a condition of capsular contracture that reduces both active and passive glenohumeral motion. The cause of adhesive capsulitis is not known but it is strongly associated with endocrine abnormalities such as diabetes. Diverse terminology and the absence of definitive criteria for diagnosis make evaluating treatment modalities difficult. Many treatment methods have been reported, most with some success, but few have been proved to alter the natural course of this disease. Most afflicted patients will achieve acceptable shoulder function without surgery. Those who remain debilitated after 8–12 months are reasonable candidates for invasive treatments. Here, the various treatment methods and the data to support their use are reviewed. Keywords: frozen shoulder, stiff shoulder, periarthritis, painful shoulder 

  20. 聚烯烃织物背胶干燥特性及干燥模型研究%Study on drying characteristics and drying model of polyolefin fabric adhesive

    许利; 林珩; 易红玲; 贾丽洲; 郑柏存

    2014-01-01

    研究了聚烯烃织物背胶在不同干燥温度和风速时的干燥曲线、干燥速率曲线、水分有效扩散系数(Def )以及干燥活化能(Ea),建立了干燥的数学模型。研究结果表明:聚烯烃织物背胶的整个干燥过程属于降速干燥,干燥温度和风速的升高都有利于缩短干燥时间;Page模型能较好描述聚烯烃织物背胶的干燥过程,并且Def为(2.46~4.15)×10-8 m2/s ,Ea为26.95 kJ/mol。%The drying curves,drying rate curves,moisture effective diffusivity(Def) and drying activation energy(Ea)of polyolefin fabric adhesive were investigated at different drying temperatures and air velocities. The drying mathematics model of the polyolefin fabric adhesive was established. The research results showed that the entire drying process of polyolefin fabric adhesive was falling rate drying. The drying time was shortened with increasing drying temperatures and air velocities. The Page model could preferably describe the drying process of the polyolefin fabric adhesive,and the Def and Ea were(2.46-4.15)×10-8 m2/s and 26.95 kJ/mol respectively.

  1. Study on drying characteristics and drying model of polyolefin fabric adhesive%聚烯烃织物背胶干燥特性及干燥模型研究

    许利; 林珩; 易红玲; 贾丽洲; 郑柏存

    2014-01-01

    The drying curves,drying rate curves,moisture effective diffusivity(Def) and drying activation energy(Ea)of polyolefin fabric adhesive were investigated at different drying temperatures and air velocities. The drying mathematics model of the polyolefin fabric adhesive was established. The research results showed that the entire drying process of polyolefin fabric adhesive was falling rate drying. The drying time was shortened with increasing drying temperatures and air velocities. The Page model could preferably describe the drying process of the polyolefin fabric adhesive,and the Def and Ea were(2.46-4.15)×10-8 m2/s and 26.95 kJ/mol respectively.%研究了聚烯烃织物背胶在不同干燥温度和风速时的干燥曲线、干燥速率曲线、水分有效扩散系数(Def )以及干燥活化能(Ea),建立了干燥的数学模型。研究结果表明:聚烯烃织物背胶的整个干燥过程属于降速干燥,干燥温度和风速的升高都有利于缩短干燥时间;Page模型能较好描述聚烯烃织物背胶的干燥过程,并且Def为(2.46~4.15)×10-8 m2/s ,Ea为26.95 kJ/mol。

  2. Syndecans and cell adhesion

    Couchman, J R; Chen, L; Woods, A

    2001-01-01

    Now that transmembrane signaling through primary cell-matrix receptors, integrins, is being elucidated, attention is turning to how integrin-ligand interactions can be modulated. Syndecans are transmembrane proteoglycans implicated as coreceptors in a variety of physiological processes, including...... cell adhesion, migration, response to growth factors, development, and tumorigenesis. This review will describe this family of proteoglycans in terms of their structures and functions and their signaling in conjunction with integrins, and indicate areas for future research....

  3. Determination of the Complex Dielectric Permittivity Industrial Materials of the Adhesive Products for the Modeling of an Electromagnetic Field at the Level of a Glue Joint

    Mahmoud Abbas

    2011-05-01

    Full Text Available To achieve out this work we were interested in the study of microwaves techniques and also of the measurement of complex relative dielectric permittivity. It is important to measure this dielectric permittivity for the used adhesive before subjecting it to electromagnetic energy. This prediction enables us to avoid an exothermic phenomenon due to the brutal rise in the temperature in the joint of adhesive. However, these results are used calculations program, to trace cartography of the electric field and of a temperature gradient in standardized test-tubes. At the end of this step, we have physical and experimental tools that can be used in the study of an optimized process using the microwaves. We check also the strong absorption of energy on the level of joint of adhesive (attenuation electric field, that the microwaves make it possible to well polymerize the adhesives with less times and low energy consumption without rise in prejudicial temperature of the parts to be stucked.

  4. Metal-ceramic adhesion: Synthesis of aluminum and chromium mixed metal oxides and extended Hueckel modeling of metal-metal oxide interfaces

    Boorse, R.S.

    1993-01-01

    Methods of chemical synthesis and theoretical calculation was used to form new materials that have improved adhesion of a thin metal film to a ceramic. Two goals of this investigation were to develop new synthesis of metal-ceramic couples with improved adhesion between the two components and a fundamental understanding of the chemical factors that affect adhesion. Extended Hueckel calculations were performed on a series of Pt- and NiPt-NiO metal-ceramic couples to examine bonding. The calculations showed an 5 fold increase in adhesion energy in NiPt-NiO over Pt-NiO. Bonding across the interface is found to decrease with increased electron donation as interfacially antibonding orbitals are filled. The synthesis of (Al[sub 1[minus]x]Cr[sub x])[sub 2]O[sub 3] mixed metal oxide powders and coatings by sol-gel methodology utilizing three chromium precursors is reported. Thus, Al[Cr(CO)[sub 3]C[sub 5]H[sub 5

  5. Ceramic microstructure and adhesion

    Buckley, D. H.

    1985-01-01

    When a ceramic is brought into contact with a ceramic, a polymer, or a metal, strong bond forces can develop between the materials. The bonding forces will depend upon the state of the surfaces, cleanliness and the fundamental properties of the two solids, both surface and bulk. Adhesion between a ceramic and another solid are discussed from a theoretical consideration of the nature of the surfaces and experimentally by relating bond forces to interface resulting from solid state contact. Surface properties of ceramics correlated with adhesion include, orientation, reconstruction and diffusion as well as the chemistry of the surface specie. Where a ceramic is in contact with a metal their interactive chemistry and bond strength is considered. Bulk properties examined include elastic and plastic behavior in the surficial regions, cohesive binding energies, crystal structures and crystallographic orientation. Materials examined with respect to interfacial adhesive interactions include silicon carbide, nickel zinc ferrite, manganese zinc ferrite, and aluminum oxide. The surfaces of the contacting solids are studied both in the atomic or molecularly clean state and in the presence of selected surface contaminants.

  6. Material characterization of structural adhesives in the lap shear mode

    Sancaktar, E.; Schenck, S. C.

    1983-01-01

    A general method for characterizing structual adhesives in the bonded lap shear mode is proposed. Two approaches in the form of semiempirical and theoretical approaches are used. The semiempirical approach includes Ludwik's and Zhurkov's equations to describe respectively, the failure stresses in the constant strain rate and constant stress loading modes with the inclusion of the temperature effects. The theoretical approach is used to describe adhesive shear stress-strain behavior with the use of viscoelastic or nonlinear elastic constitutive equations. Two different model adhesives are used in the single lap shear mode with titanium adherends. These adhesives (one of which was developed at NASA Langley Research Center) are currently considered by NASA for possible aerospace applications. Use of different model adhesives helps in assessment of the generality of the method.

  7. Engineering bio-adhesive functions in an antimicrobial polymer multilayer

    Functionalization of a biomaterial surface with adhesive ligands is an effective way to promote specific cell adhesion. Ideally, biomaterial for applications in biomedical implants should simultaneously promote host cell adhesion and inhibit bacterial adhesion. Currently, little attention has been paid to the design of antimicrobial biomaterial with selective adhesiveness towards only targeted cells or tissues. In this study, the role of two typical adhesive ligands on the bioadhesion functions of a model antimicrobial film was elucidated. First, an adhesive ligand including an RGD peptide or collagen (CL) was chemically coupled to an antimicrobial polymeric multilayer composed of dextran sulfate (DS) and chitosan (CS). It was demonstrated that the density of RGD and CL immobilized on the DS/CS multilayer ranges between 4 to 137 ng cm−2 and 100 to 1000 ng cm−2, respectively. Then the effect of immobilized RGD or CL on both bacterial and fibroblast adhesion was investigated. By determining the density and morphology of adherent fibroblast on a DS/CS multilayer with or without an adhesive ligand, it was shown that RGD or CL effectively promoted fibroblast adhesion and proliferation in a concentration-dependent manner. Interestingly, the type of adhesive ligands imposed distinct effects in bacterial adhesion. Immobilized RGD did not enhance Staphylococcus aureus and Escherichia coli adhesion on DS/CS multilayers under all concentrations. In contrast, CL triggered significant S. aureus adhesion on DS/CS multilayers even at low surface concentration and when fibroblast adhesion was absent. Moreover, the detachment forces of individual S. aureus on CL coated DS/CS multilayers probed by atomic force microscopy (AFM) was 3 times and 20 times higher than that on the control substrate and on unmodified DS/CS multilayers, respectively. Interestingly, the lowest detachment force of E. coli was found on the CL coated DS/CS multilayers. This study demonstrated the

  8. Characterization of adhesively bonded joints using bulk adhesive properties

    Kon, Haruhiko

    1991-01-01

    Though using bulk adhesive properties to predict adhesively bonded joint response has yet to be proven infallible, based upon the success of previous works, this effort attempts to shed some light on the stresses present in a typical automotive bonded joint. Adhesive material properties obtained in previous works were used in a finite element analysis of a simulated automotive joint to predict the stresses in that joint. The automotive joint analyzed was a simplified repr...

  9. The structure and properties of quartz crystals grown from fluoride solutions: Part II. The burgers vector of the growth screw superdislocations

    The birefringence method is used to investigate the distribution of microstresses around screw superdislocations with a hollow core in quartz crystals and to determine the Burgers vector and core size. The core size was found to be 5 x 10-7 m; this value was confirmed independently by studying the light diffraction on hollow cores in different quartz cuts.

  10. Prediction of the adhesive behavior of bio-inspired functionally graded materials against rough surfaces

    Chen Peijian; Peng Juan; Zhao Yucheng; Gao Feng

    2014-01-01

    Roughness effect and adhesion properties are important characteristics to be accessed in the development of functionally graded materials for biological and biomimetic applications, particularly for the hierarchical composition in biomimetic gecko robot. A multi-asperities adhesion model to predict the adhesive forces is presented in this work. The effect of surface roughness and graded material properties, which significantly alter the adhesive strength between contact bodies, can be simulta...

  11. Wall Climbing Robot Using Electrostatic Adhesion Force Generated by Flexible Interdigital Electrodes

    Rong Liu; Rui Chen; Hua Shen; Rong Zhang

    2013-01-01

    Electrostatic adhesion technology has broad application prospects on wall climbing robots because of its unique characteristics compared with other types of adhesion technologies. A double tracked wall climbing robot based on electrostatic adhesion technology is presented including electrode panel design, mechanical structure design, power supply system design and control system design. A theoretical adhesion model was established and the electrostatic potential and field were expressed by se...

  12. Adhesive tape exfoliation

    Bohr, Jakob

    2015-01-01

    Single-crystal graphite can be cleaved by the use of an adhesive tape. This was also the initial route for obtaining graphene, a one-layer thick graphite slab. In this letter a few simple and fun considerations are presented in an attempt to shed some light on why this procedure is successful. In...... particular on the nature of the surprisingly small number of repetitive steps that are needed in order to obtain a single-layer slab. Two frameworks for exfoliation are investigated: parallel exfoliation involving repetitive simultaneous cleaving, the other, serial exfoliation, which involves the repetitive...

  13. Polyurethane adhesive ingestion.

    Fitzgerald, Kevin T; Bronstein, Alvin C

    2013-02-01

    Polyurethane adhesives are found in a large number of household products in the United States and are used for a variety of purposes. Several brands of these expanding wood glues (those containing diphenylmethane diisocyanate [MDI]) have the potential to form gastrointestinal (GI) foreign bodies if ingested. The ingested adhesive forms an expanding ball of glue in the esophagus and gastric lumen. This expansion is caused by a polymerization reaction using the heat, water, and gastric acids of the stomach. A firm mass is created that can be 4-8 times its original volume. As little as 2 oz of glue have been reported to develop gastric foreign bodies. The obstructive mass is reported to form within minutes of ingestion of the adhesive. The foreign body can lead to esophageal impaction and obstruction, airway obstruction, gastric outflow obstruction, mucosal hemorrhage, ulceration, laceration, perforation of the esophageal and gastric linings, and death. Clinical signs following ingestion include anorexia, lethargy, vomiting, tachypnea, and abdominal distention and pain, and typically develop within 12 hours. Clinical signs may depend upon the size of the mass. If left untreated, perforation and rupture of the esophagus or stomach can occur. The glue mass does not stick to the GI mucosa and is not always detectable on abdominal palpation. Radiographs are recommended to confirm the presence of the "glue-ball" foreign body, and radiographic evidence of the obstruction may be seen as early as 4-6 hours following ingestion. Emesis is contraindicated owing to the risk of aspiration of the glue into the respiratory tree or the subsequent lodging of the expanding glue mass in the esophagus. Likewise, efforts to dilute the glue and prevent the formation of the foreign body through administration of liquids, activated charcoal, or bulk-forming products to push the foreign body through the GI tract have proven ineffective. Even endoscopy performed to remove the foreign body has

  14. Investigation of Efficacy of Mitomycin-C, Sodium Hyaluronate and Human Amniotic Fluid in Preventing Epidural Fibrosis and Adhesion Using a Rat Laminectomy Model

    Bolat, Elif; Kocamaz, Erdoğan; Kulahcilar, Zeki; Yilmaz, Ali; Topcu, Abdullah; Ozdemir, Mevci; Coskun, Mehmet Erdal

    2013-01-01

    Study Design A retrospective study. Purpose The aim of this study was to evalute the effects of mitomycin-C, sodium hyaluronate and human amniotic fluid on preventing spinal epidural fibrosis. Overview of Literature The role of scar tissue in pain formation is not exactly known, but it is reported that scar tissue causes adhesions between anatomic structures. Intensive fibrotic tissue compresses on anatomic structures and increases the sensitivity of the nerve root for recurrent herniation an...

  15. 3D Modeling of the Elastic-Plastic Behavior of Thin Aeronautical Adhesive Films Suited for a Wide Range of Tensile/Compression-Shear Loads

    Maurice, Julien; Creac'Hcadec, Romain; Cognard, Jean-Yves; Davies, Peter; Meirinhos, Georges; Mahdi, Stephane

    2013-01-01

    Adhesive bonding is an interesting structural assembling technique for weight saving in modern commercial aircraft, in which the use of composites materials is increasing. In order to meet both optimization and respect of safety conception constraints, the development of accurate numerical strategies is required. Thus, improvement in the experimental characterization and in the design of reliable numerical tools for bonded assemblies is necessary. This paper presents the characterization of t...

  16. Syndecan proteoglycans and cell adhesion

    Woods, A; Oh, E S; Couchman, J R

    1998-01-01

    It is now becoming clear that a family of transmembrane proteoglycans, the syndecans, have important roles in cell adhesion. They participate through binding of matrix ligand to their glycosaminoglycan chains, clustering, and the induction of signaling cascades to modify the internal microfilament...... organization. Syndecans can modulate the type of adhesive responses induced by other matrix ligand-receptor interactions, such as those involving the integrins, and so contribute to the control of cell morphology, adhesion and migration....

  17. Sensory and Physicochemical Studies of Thermally Micronized Chickpea (Cicer arietinum) and Green Lentil (Lens culinaris) Flours as Binders in Low-Fat Beef Burgers.

    Shariati-Ievari, Shiva; Ryland, Donna; Edel, Andrea; Nicholson, Tiffany; Suh, Miyoung; Aliani, Michel

    2016-05-01

    Pulses are known to be nutritious foods but are susceptible to oxidation due to the reaction of lipoxygenase (LOX) with linolenic and linoleic acids which can lead to off flavors caused by the formation of volatile organic compounds (VOCs). Infrared micronization at 130 and 150 °C was investigated as a heat treatment to determine its effect on LOX activity and VOCs of chickpea and green lentil flour. The pulse flours were added to low-fat beef burgers at 6% and measured for consumer acceptability and physicochemical properties. Micronization at 130 °C significantly decreased LOX activity for both flours. The lentil flour micronized at 150 °C showed a further significant decrease in LOX activity similar to that of the chickpea flour at 150 °C. The lowering of VOCs was accomplished more successfully with micronization at 130 °C for chickpea flour while micronization at 150 °C for the green lentil flour was more effective. Micronization minimally affected the characteristic fatty acid content in each flour but significantly increased omega-3 and n-6 fatty acids at 150 °C in burgers with lentil and chickpea flours, respectively. Burgers with green lentil flour micronized at 130 and 150 °C, and chickpea flour micronized at 150 °C were positively associated with acceptability. Micronization did not affect the shear force and cooking losses of the burgers made with both flours. Formulation of low-fat beef burgers containing 6% micronized gluten-free binder made from lentil and chickpea flour is possible based on favorable results for physicochemical properties and consumer acceptability. PMID:26990186

  18. Adhesion and non-linear rheology of adhesives with supramolecular crosslinking points.

    Callies, X; Fonteneau, C; Pensec, S; Bouteiller, L; Ducouret, G; Creton, C

    2016-09-14

    Soft supramolecular materials are promising for the design of innovative and highly tunable adhesives. These materials are composed of polymer chains functionalized by strongly interacting moieties, sometimes called "stickers". In order to systematically investigate the effect of the presence of associative groups on the debonding properties of a supramolecular adhesive, a series of supramolecular model systems has been characterized by probe-tack tests. These model materials, composed of linear and low dispersity poly(butylacrylate) chains functionalized in the middle by a single tri-urea sticker, are able to self-associate by six hydrogen bonds and range in molecular weight (Mn) between 5 and 85 kg mol(-1). The linear rheology and the nanostructure of the same materials (called "PnBA3U") were the object of a previous study. At room temperature, the association of polymers via hydrogen bonds induces the formation of rod-like aggregates structured into bundles for Mn tools analysis developed by our group. The measure of the projected area covered by cavities growing in the adhesive layer during debonding can be used to estimate the true stress in the walls of the cavities and thus to characterize the in situ large strain deformation of the thin layer during the adhesion test itself. This analysis revealed in particular that the PnBA3U materials with Mn < 40 kg mol(-1) soften very markedly at large deformation like yield stress fluids, explaining the low adhesion energies measured for these viscoelastic gels. PMID:27498899

  19. The neural cell adhesion molecule

    Berezin, V; Bock, E; Poulsen, F M

    2000-01-01

    During the past year, the understanding of the structure and function of neural cell adhesion has advanced considerably. The three-dimensional structures of several of the individual modules of the neural cell adhesion molecule (NCAM) have been determined, as well as the structure of the complex...... between two identical fragments of the NCAM. Also during the past year, a link between homophilic cell adhesion and several signal transduction pathways has been proposed, connecting the event of cell surface adhesion to cellular responses such as neurite outgrowth. Finally, the stimulation of neurite...

  20. Analysis of the surface effects on adhesion in MEMS structures

    Rusu, F.; Pustan, M.; Bîrleanu, C.; Müller, R.; Voicu, R.; Baracu, A.

    2015-12-01

    One of the main failure causes in microelectromechanical systems (MEMS) is stiction. Stiction is the adhesion of contacting surfaces due to surface forces. Adhesion force depends on the operating conditions and is influenced by the contact area. In this study, the adhesion force between MEMS materials and the AFM tips is analyzed using the spectroscopy in point mode of the AFM. The aim is to predict the stiction failure mode in MEMS. The investigated MEMS materials are silicon, polysilicon, platinum, aluminum, and gold. Three types of investigations were conducted. The first one aimed to determine the variation of the adhesion force with respect to the variation of the roughness. The roughness has a strong influence on the adhesion because the contact area between components increases if the roughness decreases. The second type of investigation aimed to determine the adhesion force in multiple points of each considered sample. The values obtained experimentally for the adhesion force were also validated using the JKR and DMT models. The third type of investigation was conducted with the purpose of determining the influence of the temperature on the adhesion force.

  1. Shewanella putrefaciens adhesion and biofilm formation on food processing surfaces

    Bagge, Dorthe; Hjelm, M.; Johansen, C.;

    2001-01-01

    Laboratory model systems were developed for studying Shewanella putrefaciens adhesion and biofilm formation under batch and flow conditions. S. putrefaciens plays a major role in food spoilage and may cause microbially induced corrosion on steel surfaces. S. putrefaciens bacteria suspended...

  2. Bacterial adhesion to glass and metal-oxide surfaces.

    Li, Baikun; Logan, Bruce E

    2004-07-15

    significantly (P < 10(-25)) correlated with total adhesion free energy (U) between the bacteria and surface (A = 2162e(-1.8U)). Although the correlation was significant, agreement between the model and data was poor for the low energy surfaces (R2 = 0.68), indicating that better models or additional methods to characterize bacteria and surfaces are still needed to more accurately describe initial bacterial adhesion to inorganic surfaces. PMID:15261011

  3. Unveiling the significance of eigenvectors in diffusing non-hermitian matrices by identifying the underlying Burgers dynamics

    Burda, Zdzislaw; Nowak, Maciej A; Tarnowski, Wojciech; Warchoł, Piotr

    2015-01-01

    Following our recent letter, we study in detail an entry-wise diffusion of non-hermitian complex matrices. We obtain an exact partial differential equation (valid for any matrix size $N$ and arbitrary initial conditions) for evolution of the averaged extended characteristic polynomial. The logarithm of this polynomial has an interpretation of a potential which generates a Burgers dynamics in quaternionic space. The dynamics of the ensemble in the large $N$ is completely determined by the coevolution of the spectral density and a certain eigenvector correlation function. This coevolution is best visible in an electrostatic potential of a quaternionic argument built of two complex variables, the first of which governs standard spectral properties while the second unravels the hidden dynamics of eigenvector correlation function. We obtain general large $N$ formulas for both spectral density and 1-point eigenvector correlation function valid for any initial conditions. We exemplify our studies by solving three ex...

  4. Experimental model of the formation of pelvic adhesions by videolaparoscopic in female rabbits Modelo experimental de formação de aderências pélvicas por videolaparoscopia em coelhas

    Rosi Pereira Balbinotto

    2010-02-01

    Full Text Available PURPOSE: To verify the frequency of postsurgical pelvic adhesion formation in an experimental animal model using videolaparoscopy. METHODS: Experimental study in a sample of 11 non-pregnant female rabbits, aged 5 to 7 months. After general anesthesia, access to the abdominal cavity was performed by an open puncture technique, with 10mm optics, placing two other 5 mm trochars under direct visualization, in the iliac fossae. Then a fragment of peritoneum was resected, followed by electrocauterization. In 21 days, the videolaparoscopy was repeated, and adhesion formation and score was looked at, with biopsies at the surgical site. RESULTS: 54 % of adhesion formation was observed, and the median score of adhesions was 6 (minimum of 3 and maximum of 10, all of them found in the bladder and the anterior abdominal wall. CONCLUSION: The method used presents a high frequency of intra-abdominal adhesion formation.OBJETIVO: Verificar a freqüência da formação de aderências pélvicas pós-cirúrgicas, em um modelo experimental animal, por videolaparoscopia. MÉTODOS: Estudo experimental, em uma amostra de 11 coelhas, não prenhas, com idade entre cinco e sete meses. Após anestesia geral, o acesso da cavidade abdominal foi efetuado por técnica de punção aberta, com óptica de 10 mm, colocando-se outros dois trocateres de 5 mm, sob visão direta, nas fossas ilíacas. Realizou-se, então, ressecção de fragmento de peritônio, seguida de cauterização com eletrocautério. Em 21 dias, foi repetida a videolaparoscopia, verificando-se a formação e escore de aderências e realizando-se biópsias do local da cirurgia. RESULTADOS: Observou-se 54,5% de formação de aderências, sendo o escore total mediano de aderências seis (mínimo de três e máximo de 10, todas encontradas na bexiga e na parede abdominal anterior. CONCLUSÃO: O procedimento utilizado apresentou alta freqüência de formação de aderências intra-abdominais.

  5. Stretchable, Adhesion-Tunable Dry Adhesive by Surface Wrinkling

    Jeong, Hoon Eui

    2010-02-16

    We introduce a simple yet robust method of fabricating a stretchable, adhesion-tunable dry adhesive by combining replica molding and surface wrinkling. By utilizing a thin, wrinkled polydimethyl siloxane (PDMS) sheet with a thickness of 1 mm with built-in micropillars, active, dynamic control of normal and shear adhesion was achieved. Relatively strong normal (∼10.8 N/cm2) and shear adhesion (∼14.7 N/cm2) forces could be obtained for a fully extended (strained) PDMS sheet (prestrain of∼3%), whereas the forces could be rapidly reduced to nearly zero once the prestrain was released (prestrain of ∼0.5%). Moreover, durability tests demonstrated that the adhesion strength in both the normal and shear directions was maintained over more than 100 cycles of attachment and detachment. © 2010 American Chemical Society.

  6. Improved Adhesion and Compliancy of Hierarchical Fibrillar Adhesives.

    Li, Yasong; Gates, Byron D; Menon, Carlo

    2015-08-01

    The gecko relies on van der Waals forces to cling onto surfaces with a variety of topography and composition. The hierarchical fibrillar structures on their climbing feet, ranging from mesoscale to nanoscale, are hypothesized to be key elements for the animal to conquer both smooth and rough surfaces. An epoxy-based artificial hierarchical fibrillar adhesive was prepared to study the influence of the hierarchical structures on the properties of a dry adhesive. The presented experiments highlight the advantages of a hierarchical structure despite a reduction of overall density and aspect ratio of nanofibrils. In contrast to an adhesive containing only nanometer-size fibrils, the hierarchical fibrillar adhesives exhibited a higher adhesion force and better compliancy when tested on an identical substrate. PMID:26167951

  7. Effect of adhesive thickness on adhesively bonded T-joint

    The aim of this work is to analyze the effect of adhesive thickness on tensile strength of adhesively bonded stainless steel T-joint. Specimens were made from SUS 304 Stainless Steel plate and SUS 304 Stainless Steel perforated plate. Four T-joint specimens with different adhesive thicknesses (0.5, 1.0, 1.5 and 2.0 mm) were made. Experiment result shows T-joint specimen with adhesive thickness of 1.0 mm yield highest maximum load. Identical T-joint specimen jointed by spot welding was also tested. Tensile test shows welded T-Joint had eight times higher tensile load than adhesively bonded T-joint. However, in low pressure application such as urea granulator chamber, high tensile strength is not mandatory. This work is useful for designer in fertilizer industry and others who are searching for alternative to spot welding

  8. Numerical study on multiphase flows induced by wall adhesion

    Myong, Hyon Kook [Kookmin Univ., Seoul (Korea, Republic of)

    2012-07-15

    The present paper presents a numerical study on multiphase flows induced by wall adhesion. The continuum surface force (CSF) model with the wall adhesion boundary condition model is used for calculating the surface tension force; this model is implemented in an in house solution code (PowerCFD). The present method (code) employs an unstructured cell centered method based on a conservative pressure based finite volume method with a volume capturing method (CICSAM) in a volume of fluid (VOF) scheme for phase interface capturing. The effects of wall adhesion are then numerically simulated by using the present method for a shallow pool of water located at the bottom of a cylindrical tank with no external forces such as gravity. Two different cases are computed, one it which the water wets the wall and one in which the water does not wet the wall. It is found that the present method efficiently simulates the surface tension dominant multiphase flows induced by wall adhesion.

  9. Syndecans, signaling, and cell adhesion

    Couchman, J R; Woods, A

    1996-01-01

    structures within the heparan sulfate chains, leaving the roles of chondroitin sulfate chains and extracellular portion of the core proteins to be elucidated. Evidence that syndecans are a class of receptor involved in cell adhesion is mounting, and their small cytoplasmic domains may link with the...... transmembrane signaling from matrix to cytoskeleton, as proposed for other classes of adhesion receptors....

  10. Hyaluronan-mediated cellular adhesion

    Curtis, Jennifer

    2005-03-01

    Many cells surround themselves with a cushioning halo of polysaccharides that is further strengthened and organized by proteins. In fibroblasts and chrondrocytes, the primary component of this pericellular matrix is hyaluronan, a large linear polyanion. Hyaluronan production is linked to a variety of disease, developmental, and physiological processes. Cells manipulate the concentration of hyaluronan and hyaluronan receptors for numerous activities including modulation of cell adhesion, cell motility, and differentiation. Recent investigations by identify hyaluronan's role in mediating early-stage cell adhesion. An open question is how the cell removes the 0.5-10 micron thick pericellular matrix to allow for further mature adhesion events requiring nanometer scale separations. In this investigation, holographic optical tweezers are used to study the adhesion and viscoelastic properties of chondrocytes' pericellular matrix. Ultimately, we aim to shed further light on the spatial and temporal details of the dramatic transition from micron to nanometer gaps between the cell and its adhesive substrate.

  11. [Retention of adhesive bridges].

    Raes, F; De Boever, J

    1994-04-01

    Since the development of adhesive bridges in the early seventies, the retention and therefore the durability of these bridges has been tremendously improved. Conditioning of the non-precious metal by silanisation, careful acid etching of the enamel and the use of the appropriate composite resin are of prime importance. Furthermore, the meticulous preparation with enough interproximal embrace, occlusal rests, interocclusal clearance and cingulum stops is equally important. Including more teeth in the design does not necessarily lead to an improved retention. Besides the material and technical aspects, the whole clinical procedure needs much attention. The retention does not depend on one single factor, but on the precision of all the necessary clinical steps and on a well-defined selection of the material. In this way a five-year survival rate of close to 80% can be obtained. PMID:11830965

  12. Effect of fibril shape on adhesive properties

    Soto, Daniel; Hill, Ginel; Parness, Aaron; Esparza, Noé; Cutkosky, Mark; Kenny, Tom

    2010-08-01

    Research into the gecko's adhesive system revealed a unique architecture for adhesives using tiny hairs. By using a stiff material (β-keratin) to create a highly structured adhesive, the gecko's system demonstrates properties not seen in traditional pressure-sensitive adhesives which use a soft, unstructured planar layer. In contrast to pressure sensitive adhesives, the gecko adhesive displays frictional adhesion, in which increased shear force allows it to withstand higher normal loads. Synthetic fibrillar adhesives have been fabricated but not all demonstrate this frictional adhesion property. Here we report the dual-axis force testing of single silicone rubber pillars from synthetic adhesive arrays. We find that the shape of the adhesive pillar dictates whether frictional adhesion or pressure-sensitive behavior is observed. This work suggests that both types of behavior can be achieved with structures much larger than gecko terminal structures. It also indicates that subtle differences in the shape of these pillars can significantly influence their properties.

  13. Influence of antioxidant complex on the adhesion of leukocytes in chronic venous insufficiency of lower limbs in rats

    Mark Plotnikov

    2012-01-01

    Conclusions: Model of CVI of lower limb is accompanied by increased venous pressure and raised adhesion activity of leukocytes. Administration of AOC for 14 days reduces the adhesive activity of leukocytes.

  14. The present and future of biologically inspired adhesive interfaces and materials.

    Brubaker, Carrie E; Messersmith, Phillip B

    2012-01-31

    The natural world provides many examples of robust, permanent adhesive platforms. Synthetic adhesive interfaces and materials inspired by mussels of genus Mytulis have been extensively applied, and it is expected that characterization and adaptation of several other biological adhesive strategies will follow the Mytilus edulis model. These candidate species will be introduced, along with a discussion of the adhesive behaviors that make them attractive for synthetic adaptation. While significant progress has been made in the development of biologically inspired adhesive interfaces and materials, persistent questions, current challenges, and emergent areas of research will be also be discussed. PMID:22224862

  15. Impact of oils and coatings on adhesion of structural adhesives

    Hagström, Marcus

    2015-01-01

    This is a master thesis project conducted for Scania CV AB in collaboration with Swerea Kimab. The purpose is to examine how oils and coatings on the surface affect the adhesion of adhesives. Earlier work done by Scania indicate that the amount of oil applied may have an impact on the adhesion. Substrates tested are hot dipped galvanised steel, electro galvanised. AlSi and ZnMg. Oils used are Anticorit RP 3802 that is an anti-corrosive oil and Renoform 3802 that is a drawing oil. The two adhes...

  16. Nonlinear viscoelastic characterization of structural adhesives

    Rochefort, M. A.; Brinson, H. F.

    1983-01-01

    Measurements of the nonliner viscoelastic behavior of two adhesives, FM-73 and FM-300, are presented and discussed. Analytical methods to quantify the measurements are given and fitted into a framework of an accelerated testing and analysis procedure. The single integral model used is shown to function well and is analogous to a time-temperature stress-superposition procedure (TTSSP). Advantages and disadvantages of the creep power law method used in this study are given.

  17. Preparation and characterization of hierarchical patterned adhesives

    Bauer, Christina T.

    2015-01-01

    The remarkable adherence of geckos is attributed to the hierarchical structure on their feet pads. Although significant progress has been made, inspired by nature, in fabrication of dry adhesive materials on smooth surfaces, materials with similar adherence against rough surfaces are yet to be found. To better understand the effect of hierarchy on adherence we fabricated macroscopic models made of polydimethylsiloxane with different levels of hierarchy that were brought into contact with glas...

  18. Wet adhesion and adhesive locomotion of snails on anti-adhesive non-wetting surfaces.

    Neil J Shirtcliffe

    Full Text Available Creating surfaces capable of resisting liquid-mediated adhesion is extremely difficult due to the strong capillary forces that exist between surfaces. Land snails use this to adhere to and traverse across almost any type of solid surface of any orientation (horizontal, vertical or inverted, texture (smooth, rough or granular or wetting property (hydrophilic or hydrophobic via a layer of mucus. However, the wetting properties that enable snails to generate strong temporary attachment and the effectiveness of this adhesive locomotion on modern super-slippy superhydrophobic surfaces are unclear. Here we report that snail adhesion overcomes a wide range of these microscale and nanoscale topographically structured non-stick surfaces. For the one surface which we found to be snail resistant, we show that the effect is correlated with the wetting response of the surface to a weak surfactant. Our results elucidate some critical wetting factors for the design of anti-adhesive and bio-adhesion resistant surfaces.

  19. Wet Adhesion and Adhesive Locomotion of Snails on Anti-Adhesive Non-Wetting Surfaces

    Shirtcliffe, Neil J.; McHale, Glen; Newton, Michael I.

    2012-01-01

    Creating surfaces capable of resisting liquid-mediated adhesion is extremely difficult due to the strong capillary forces that exist between surfaces. Land snails use this to adhere to and traverse across almost any type of solid surface of any orientation (horizontal, vertical or inverted), texture (smooth, rough or granular) or wetting property (hydrophilic or hydrophobic) via a layer of mucus. However, the wetting properties that enable snails to generate strong temporary attachment and the effectiveness of this adhesive locomotion on modern super-slippy superhydrophobic surfaces are unclear. Here we report that snail adhesion overcomes a wide range of these microscale and nanoscale topographically structured non-stick surfaces. For the one surface which we found to be snail resistant, we show that the effect is correlated with the wetting response of the surface to a weak surfactant. Our results elucidate some critical wetting factors for the design of anti-adhesive and bio-adhesion resistant surfaces. PMID:22693563

  20. Epithelial to mesenchymal transition-the roles of cell morphology, labile adhesion and junctional coupling.

    Abdulla, Tariq; Luna-Zurita, Luis; de la Pompa, José Luis; Schleich, Jean-Marc; Summers, Ron

    2013-08-01

    Epithelial to mesenchymal transition (EMT) is a fundamental process during development and disease, including development of the heart valves and tumour metastases. An extended cellular Potts model was implemented to represent the behaviour emerging from autonomous cell morphology, labile adhesion, junctional coupling and cell motility. Computer simulations normally focus on these functional changes independently whereas this model facilitates exploration of the interplay between cell shape changes, adhesion and migration. The simulation model is fitted to an in vitro model of endocardial EMT, and agrees with the finding that Notch signalling increases cell-matrix adhesion in addition to modulating cell-cell adhesion. PMID:23787029

  1. Marine Bioinspired Underwater Contact Adhesion.

    Clancy, Sean K; Sodano, Antonio; Cunningham, Dylan J; Huang, Sharon S; Zalicki, Piotr J; Shin, Seunghan; Ahn, B Kollbe

    2016-05-01

    Marine mussels and barnacles are sessile biofouling organisms that adhere to a number of surfaces in wet environments and maintain remarkably strong bonds. Previous synthetic approaches to mimic biological wet adhesive properties have focused mainly on the catechol moiety, present in mussel foot proteins (mfps), and especially rich in the interfacial mfps, for example, mfp-3 and -5, found at the interface between the mussel plaque and substrate. Barnacles, however, do not use Dopa for their wet adhesion, but are instead rich in noncatecholic aromatic residues. Due to this anomaly, we were intrigued to study the initial contact adhesion properties of copolymerized acrylate films containing the key functionalities of barnacle cement proteins and interfacial mfps, for example, aromatic (catecholic or noncatecholic), cationic, anionic, and nonpolar residues. The initial wet contact adhesion of the copolymers was measured using a probe tack testing apparatus with a flat-punch contact geometry. The wet contact adhesion of an optimized, bioinspired copolymer film was ∼15.0 N/cm(2) in deionized water and ∼9.0 N/cm(2) in artificial seawater, up to 150 times greater than commercial pressure-sensitive adhesive (PSA) tapes (∼0.1 N/cm(2)). Furthermore, maximum wet contact adhesion was obtained at ∼pH 7, suggesting viability for biomedical applications. PMID:27046671

  2. Molecular Dynamics Simulations of Adhesion at Epoxy Interfaces

    Frankland, Sarah-Jane V.; Clancy, Thomas C.; Hinkley, J. A.; Gates. T. S.

    2008-01-01

    The effect of moisture on adhesives used in aerospace applications can be modeled with chemically specific techniques such as molecular dynamics simulation. In the present study, the surface energy and work of adhesion are calculated for epoxy surfaces and interfaces, respectively, by using molecular dynamics simulation. Modifications are made to current theory to calculate the work of adhesion at the epoxy-epoxy interface with and without water. Quantitative agreement with experimental values is obtained for the surface energy and work of adhesion at the interface without water. The work of adhesion agrees qualitatively with the experimental values for the interface with water: the magnitude is reduced 15% with respect to the value for the interface without water. A variation of 26% in the magnitude is observed depending on the water configuration at a concentration of 1.6 wt%. The methods and modifications to the method that are employed to obtain these values are expected to be applicable for other epoxy adhesives to determine the effects of moisture uptake on their work of adhesion.

  3. Effect of Hypericum perforatum on intraperitoneal adhesion formation in rats

    Hızlı, Deniz; Hızlı, Fatih; Köşüş, Aydın; Yılmaz, Saynur; KÖŞÜŞ, NERMIN; HALTAŞ, Hacer; Dede, Hülya; Kafalı, Hasan

    2013-01-01

    Introduction The aim of this study was to evaluate the efficacy of Hypericum perforatum for prevention of adhesion formation in rats. Material and methods Twenty-four female wistar rats underwent left uterine horn adhesion model. Rats were randomised into 4 groups. Group 1 (Control): Closure of abdominal incision without any agent administration. Group 2: Closure of incision after administration of intraperitoneal (i.p.) Ringer's lactate solution. Group 3: Closure of incision after administra...

  4. Focal Adhesion Kinases in Adhesion Structures and Disease

    Pierre P. Eleniste

    2012-01-01

    Full Text Available Cell adhesion to the extracellular matrix (ECM is essential for cell migration, proliferation, and embryonic development. Cells can contact the ECM through a wide range of matrix contact structures such as focal adhesions, podosomes, and invadopodia. Although they are different in structural design and basic function, they share common remodeling proteins such as integrins, talin, paxillin, and the tyrosine kinases FAK, Pyk2, and Src. In this paper, we compare and contrast the basic organization and role of focal adhesions, podosomes, and invadopodia in different cells. In addition, we discuss the role of the tyrosine kinases, FAK, Pyk2, and Src, which are critical for the function of the different adhesion structures. Finally, we discuss the essential role of these tyrosine kinases from the perspective of human diseases.

  5. Focal adhesion kinases in adhesion structures and disease.

    Eleniste, Pierre P; Bruzzaniti, Angela

    2012-01-01

    Cell adhesion to the extracellular matrix (ECM) is essential for cell migration, proliferation, and embryonic development. Cells can contact the ECM through a wide range of matrix contact structures such as focal adhesions, podosomes, and invadopodia. Although they are different in structural design and basic function, they share common remodeling proteins such as integrins, talin, paxillin, and the tyrosine kinases FAK, Pyk2, and Src. In this paper, we compare and contrast the basic organization and role of focal adhesions, podosomes, and invadopodia in different cells. In addition, we discuss the role of the tyrosine kinases, FAK, Pyk2, and Src, which are critical for the function of the different adhesion structures. Finally, we discuss the essential role of these tyrosine kinases from the perspective of human diseases. PMID:22888421

  6. Effect of Moringa (Moringa oleifera leaf powder and sweet basil (Ocimum basilicum leaf paste on sensory and nutritional qualities of beef and ham burgers – A preliminary study

    Gabriel Teye

    2013-03-01

    Full Text Available Moringa leaf powder and sweet basil leaf paste are commonly used in local dishes in Ghana for purposes of flavour enhancement and nutrient supplements. This study was conducted to determine the effects of Moringa (Moringa oleifera leaf powder (MLP and Sweet basil (Ocimum basilicum leaf paste (SBLP on the sensory characteristics and nutritional compositions of beef and hamburgers. MLP and SBLP were incorporated at 0g (Control, T1, 2g, 4g and 6g/kg meat (T2, T3 and T4 respectively during the production of the burgers. The burgers were vacuum-packed and frozen for sensory and laboratory analyses. The M. oleifera leaf powder had significant (P0.01 the crude protein content but no significant effect on sensory characteristics of the products.

  7. Photovoltaic module with adhesion promoter

    Xavier, Grace

    2013-10-08

    Photovoltaic modules with adhesion promoters and methods for fabricating photovoltaic modules with adhesion promoters are described. A photovoltaic module includes a solar cell including a first surface and a second surface, the second surface including a plurality of interspaced back-side contacts. A first glass layer is coupled to the first surface by a first encapsulating layer. A second glass layer is coupled to the second surface by a second encapsulating layer. At least a portion of the second encapsulating layer is bonded directly to the plurality of interspaced back-side contacts by an adhesion promoter.

  8. Adhesives from modified soy protein

    Sun, Susan; Wang, Donghai; Zhong, Zhikai; Yang, Guang

    2008-08-26

    The, present invention provides useful adhesive compositions having similar adhesive properties to conventional UF and PPF resins. The compositions generally include a protein portion and modifying ingredient portion selected from the group consisting of carboxyl-containing compounds, aldehyde-containing compounds, epoxy group-containing compounds, and mixtures thereof. The composition is preferably prepared at a pH level at or near the isoelectric point of the protein. In other preferred forms, the adhesive composition includes a protein portion and a carboxyl-containing group portion.

  9. Focal Adhesion Kinases in Adhesion Structures and Disease

    Pierre P. Eleniste; Angela Bruzzaniti

    2012-01-01

    Cell adhesion to the extracellular matrix (ECM) is essential for cell migration, proliferation, and embryonic development. Cells can contact the ECM through a wide range of matrix contact structures such as focal adhesions, podosomes, and invadopodia. Although they are different in structural design and basic function, they share common remodeling proteins such as integrins, talin, paxillin, and the tyrosine kinases FAK, Pyk2, and Src. In this paper, we compare and contrast the basic organiza...

  10. Adhesion of nanoscale asperities with power-law profiles

    Grierson, David S.; Liu, Jingjing; Carpick, Robert W.; Turner, Kevin T.

    2013-02-01

    The behavior of single-asperity micro- and nanoscale contacts in which adhesion is present is important for the performance of many small-scale mechanical systems and processes, such as atomic force microscopy (AFM). When analyzing such problems, the bodies in contact are often assumed to have paraboloidal shapes, thus allowing the application of the familiar Johnson-Kendall-Roberts (JKR), Derjaguin-Müller-Toporov (DMT), or Maugis-Dugdale (M-D) adhesive contact models. However, in many situations the asperities do not have paraboloidal shapes and, instead, have geometries that may be better described by a power-law function. An M-D-n analytical model has recently been developed to extend the M-D model to asperities with power-law profiles. We use a combination of M-D-n analytical modeling, finite element (FE) analysis, and experimental measurements to investigate the behavior of nanoscale adhesive contacts with non-paraboloidal geometries. Specifically, we examine the relationship between pull-off force, work of adhesion, and range of adhesion for asperities with power-law-shaped geometries. FE analysis is used to validate the M-D-n model and examine the effect of the shape of the adhesive interaction potential on the pull-off force. In the experiments, the extended M-D model is applied to analyze pull-off force measurements made on nanoscale tips that are engineered via gradual wear to have power-law shapes. The experimental and modeling results demonstrate that the range of the adhesive interaction is a crucial parameter when quantifying the adhesion of non-paraboloidal tips, quite different than the familiar paraboloidal case. The application of the M-D-n model to the experimental results yields an unusually large adhesion range of 4-5 nm, a finding we attribute to either the presence of long-range van der Waals forces or deviations from continuum theory due to atomic-scale roughness of the tips. Finally, an adhesion map to aid in analysis of pull-off force

  11. Application of the (′/)-expansion method for the Burgers, Burgers–Huxley and modified Burgers–KdV equations

    H Kheiri; M R Moghaddam; V Vafaei

    2011-06-01

    In this work, we present travelling wave solutions for the Burgers, Burgers–Huxley and modified Burgers–KdV equations. The (′/)-expansion method is used to determine travelling wave solutions of these sets of equations. The travelling wave solutions are expressed by the hyperbolic functions, the trigonometric functions and the rational functions. It is shown that the proposed method is direct, effective and can be used for many other nonlinear evolution equations in mathematical physics.

  12. Tryptophan depletion and formation of alpha-aminoadipic and gamma-glutamic semialdehydes in porcine burger patties with added phenolic-rich fruit extracts.

    Ganhão, Rui; Morcuende, David; Estévez, Mario

    2010-03-24

    The effect of added fruit extracts on the oxidation of muscle proteins in porcine burger patties subjected to cooking and chill storage was studied. Extracts from arbutus berries (Arbutus unedo L., AU), common hawthorns (Crataegus monogyna L., CM), dog roses (Rosa canina L., RC), and elm-leaf blackberries (Rubus ulmifolius Schott, RU) were prepared, characterized, added to burger patties (3% of total weight), and evaluated as inhibitors of protein oxidation. Negative (no added extract, C) and positive control (added quercetin, 230 mg/kg, Q) groups were also included in the design. Protein oxidation was assessed by means of tryptophan loss using fluorescence spectroscopy (FS) and formation of the specific protein carbonyls alpha-aminoadipic (AAS) and gamma-glutamic semialdehyde (GGS) using liquid chromatography and mass spectroscopy (LC-MS). Both advanced methodologies (FS and LC-MS) were found to be reliable and specific protein oxidation measurements that allow us to gain chemical insight into protein oxidation. The mechanisms likely involved in the oxidative reactions affecting proteins during cooking and storage of burger patties are profusely discussed. Phenolic-rich fruit extracts protected tryptophan residues against oxidation and inhibited the formation of both semialdehydes in burger patties during cooking and subsequent chill storage. In general, RC, RU, and AU were the most effective inhibitors of protein oxidation, with this effect being more intense than that of pure polyphenols like quercetin. These fruit extracts could be considered functional ingredients as their antioxidant actions contribute to the enhancement of the nutritional value of the meat products. PMID:20170109

  13. Burgers vector population, dislocation types and dislocation densities in single grains extracted from a polycrystalline commercial-purity Ti specimen by X-ray line-profile analysis

    Burgers vector populations, dislocation types and dislocation densities are determined within individual grains of a polycrystalline commercial-purity titanium specimen by extending prior method of differentiating individual grains in a polycrystalline sample. The procedure has been tested at the focused X-ray beamline ID11 at the European Synchrotron Research Facility in Grenoble, France. The results provided by the method can be used as input for different crystal-plasticity calculations and for the experimental verification of numerical simulations.

  14. Arachnids secrete a fluid over their adhesive pads.

    Anne M Peattie

    Full Text Available BACKGROUND: Many arachnids possess adhesive pads on their feet that help them climb smooth surfaces and capture prey. Spider and gecko adhesives have converged on a branched, hairy structure, which theoretically allows them to adhere solely by dry (solid-solid intermolecular interactions. Indeed, the consensus in the literature is that spiders and their smooth-padded relatives, the solifugids, adhere without the aid of a secretion. METHODOLOGY AND PRINCIPAL FINDINGS: We investigated the adhesive contact zone of living spiders, solifugids and mites using interference reflection microscopy, which allows the detection of thin liquid films. Like insects, all the arachnids we studied left behind hydrophobic fluid footprints on glass (mean refractive index: 1.48-1.50; contact angle: 3.7-11.2°. Fluid was not always secreted continuously, suggesting that pads can function in both wet and dry modes. We measured the attachment forces of single adhesive setae from tarantulas (Grammostola rosea by attaching them to a bending beam with a known spring constant and filming the resulting deflection. Individual spider setae showed a lower static friction at rest (26%±2.8 SE of the peak friction than single gecko setae (Thecadactylus rapicauda; 96%±1.7 SE. This may be explained by the fact that spider setae continued to release fluid after isolation from the animal, lubricating the contact zone. SIGNIFICANCE: This finding implies that tarsal secretions occur within all major groups of terrestrial arthropods with adhesive pads. The presence of liquid in an adhesive contact zone has important consequences for attachment performance, improving adhesion to rough surfaces and introducing rate-dependent effects. Our results leave geckos and anoles as the only known representatives of truly dry adhesive pads in nature. Engineers seeking biological inspiration for synthetic adhesives should consider whether model species with fluid secretions are appropriate to their

  15. Consumer's evaluation of the effects of gamma irradiation and natural antioxidants on general acceptance of frozen beef burger

    The effect of addition of rosemary and oregano extracts on the sensory quality of irradiated beef burger was investigated. Batches of beef burgers were prepared with 400 ppm of rosemary or oregano extract and a group prepared with 200 ppm of synthetic butyl-hydroxytoluene (BHT)/butyl-hydroxy-anisol (BHA) was used as a control. Half of each formulation was irradiated at the maximum dose allowed for frozen meat (7 kGy). Samples were kept under frozen conditions (-20 deg. C) during the whole storage period, including during irradiation. Two analyses were performed after 20 and 90 days to verify the influence of the addition of the different types of antioxidants and the effect of irradiation and storage time on the acceptance of the product. Thirty-three and thirty-four untrained panelists were invited to participate in the first and second test, respectively. A structured hedonic scale ranging from 1 to 9 points was used in both analyses. BHT/BHA formulation obtained the highest score (6.73) and regarding the natural antioxidants, oregano received better acceptance (6.36). Irradiated samples formulated with oregano received a lower score, 6.03 in the first test and 5.06 in the second one, compared to the non-irradiated sample (6.36 and 5.79). In the second test (90 days), the sample formulated with BHT/BHA and which was irradiated received a higher score (6.59) when compared to the non-irradiated one (5.85). In both tests, the irradiated samples formulated with rosemary extract obtained a better score compared to the non-irradiated one, the scores being 5.00-3.82 and 5.00-3.76 in the first and second test, respectively. Our results allowed us to conclude that the natural antioxidants, rosemary and oregano extracts, present a good alternative for replacing synthetic additives in food industries, and that the irradiation process, in some cases, may help to enhance the sensory quality of food

  16. Consumer's evaluation of the effects of gamma irradiation and natural antioxidants on general acceptance of frozen beef burger

    Trindade, R. A.; Lima, A.; Andrade-Wartha, E. R.; Oliveira e Silva, A. M.; Mancini-Filho, J.; Villavicencio, A. L. C. H.

    2009-04-01

    The effect of addition of rosemary and oregano extracts on the sensory quality of irradiated beef burger was investigated. Batches of beef burgers were prepared with 400 ppm of rosemary or oregano extract and a group prepared with 200 ppm of synthetic butyl-hydroxytoluene (BHT)/butyl-hydroxy-anisol (BHA) was used as a control. Half of each formulation was irradiated at the maximum dose allowed for frozen meat (7 kGy). Samples were kept under frozen conditions (-20 °C) during the whole storage period, including during irradiation. Two analyses were performed after 20 and 90 days to verify the influence of the addition of the different types of antioxidants and the effect of irradiation and storage time on the acceptance of the product. Thirty-three and thirty-four untrained panelists were invited to participate in the first and second test, respectively. A structured hedonic scale ranging from 1 to 9 points was used in both analyses. BHT/BHA formulation obtained the highest score (6.73) and regarding the natural antioxidants, oregano received better acceptance (6.36). Irradiated samples formulated with oregano received a lower score, 6.03 in the first test and 5.06 in the second one, compared to the non-irradiated sample (6.36 and 5.79). In the second test (90 days), the sample formulated with BHT/BHA and which was irradiated received a higher score (6.59) when compared to the non-irradiated one (5.85). In both tests, the irradiated samples formulated with rosemary extract obtained a better score compared to the non-irradiated one, the scores being 5.00-3.82 and 5.00-3.76 in the first and second test, respectively. Our results allowed us to conclude that the natural antioxidants, rosemary and oregano extracts, present a good alternative for replacing synthetic additives in food industries, and that the irradiation process, in some cases, may help to enhance the sensory quality of food.

  17. Failure strength prediction for adhesively bonded single lap joints

    Rahman, Niat Mahmud

    For adhesively bonded joint, failure strength depends on many factors such as material properties (both adhesive and adherend), specimen geometries, test environments, surface preparation procedures, etc. Failure occurs inside constitutive materials or along joint interfaces. Based on location, adhesively bonded failure mode can be classified as adhesive failure mode, cohesive failure mode and adherend failure mode. Failure mode directly affects the failure strength of joint. For last eight decades, researchers have developed analytical, empirical or semi-empirical methods capable of predicting failure strength for adhesively bonded joints generating either cohesive failure or adherend failure. Applicability of most of the methods is limited to particular cases. In this research, different failure modes for single lap joints (SLJs) were generated experimentally using epoxy based paste adhesive. Based on experimental data and analytical study, simplified failure prediction methods were developed for each failure mode. For adhesive failure mode, it is observed that peel stress distributions concur along interface near crack initiation points. All SLJs for this test endured consistent surface treatments. Geometric parameters of the joints were varied to study their effect on failure strength. Peel stress distributions were calculated using finite analysis (FEA). Based on peel stress distribution near crack initiation point, a failure model is proposed. Numerous analytical, empirical and semi-empirical models are available for predicting failure strengths of SLJs generating cohesive failures. However, most of the methods in the literature failed to capture failure behavior of SLJs having thickness of adhesive layer as variable. Cohesive failure mode was generated experimentally using aluminum as adherend and epoxy adhesive considering thickness of adhesive layers as variable within SLJs. Comparative study was performed among various methods. It was observed that

  18. Nanostructured niobium oxide coatings influence osteoblast adhesion.

    Eisenbarth, E; Velten, D; Müller, M; Thull, R; Breme, J

    2006-10-01

    The interaction of osteoblasts was correlated to the roughness of nanosized surface structures of Nb(2)O(5) coatings on polished CP titanium grade 2. Nb(2)O(5) sol-gel coatings were selected as a model surface to study the interaction of osteoblasts with nanosized surface structures. The surface roughness was quantified by determination of the average surface finish (Ra number) by means of atomic force microscopy. Surface topographies with Ra = 7, 15, and 40 nm were adjusted by means of the annealing process parameters (time and temperature) within a sol-gel coating procedure. The observed osteoblast migration was fastest on smooth surfaces with Ra = 7 nm. The adhesion strength, spreading area, and collagen-I synthesis showed the best results on an intermediate roughness of Ra = 15 nm. The surface roughness of Ra = 40 nm was rather peaked and reduced the speed of cell reactions belonging to the adhesion process. PMID:16788971

  19. Melanocyte Transformation Associated with Substrate Adhesion Impediment

    Sueli M. Oba-Shinjo

    2006-03-01

    Full Text Available Exclude experimental models of malignant transformation employ chemical and physical carcinogens or genetic manipulations to study tumor progression. In this work, different melanoma cell lines were established after submitting a nontumorigenic melanocyte lineage (melan-a to sequential cycles of forced anchorage impediment. The great majority of these cells underwent anoikis when maintained in suspension. After one deadhesion cycle, phenotypic alterations were noticeable in the few surviving cells, which became more numerous and showed progressive alterations after each adhesion impediment step. No significant differences in cell surface expression of integrins were detected, but a clear electrophoretic migration shift, compatible with an altered glycosylation pattern, was observed for β1 chain in transformed cell lines. In parallel, a progressive enrichment of tri- and tetra-antennary N-glycans was apparent, suggesting increased N-acetylglucosaminyl-transferase V activity. Alterations both in proteoglycan glycosylation pattern and core protein expression were detected during the transformation process. In conclusion, this model corroborates the role of adhesion state as a promoting agent in transformation process and demonstrates that cell adhesion disturbances may act as carcinogenic stimuli, at least for a nontumorigenic immortalized melanocyte lineage. These findings have intriguing implications for in vivo carcinogenesis, suggesting that anchorage independence may precede, and contribute to, neoplastic conversion.

  20. CADM1 controls actin cytoskeleton assembly and regulates extracellular matrix adhesion in human mast cells.

    Elena P Moiseeva

    Full Text Available CADM1 is a major receptor for the adhesion of mast cells (MCs to fibroblasts, human airway smooth muscle cells (HASMCs and neurons. It also regulates E-cadherin and alpha6beta4 integrin in other cell types. Here we investigated a role for CADM1 in MC adhesion to both cells and extracellular matrix (ECM. Downregulation of CADM1 in the human MC line HMC-1 resulted not only in reduced adhesion to HASMCs, but also reduced adhesion to their ECM. Time-course studies in the presence of EDTA to inhibit integrins demonstrated that CADM1 provided fast initial adhesion to HASMCs and assisted with slower adhesion to ECM. CADM1 downregulation, but not antibody-dependent CADM1 inhibition, reduced MC adhesion to ECM, suggesting indirect regulation of ECM adhesion. To investigate potential mechanisms, phosphotyrosine signalling and polymerisation of actin filaments, essential for integrin-mediated adhesion, were examined. Modulation of CADM1 expression positively correlated with surface KIT levels and polymerisation of cortical F-actin in HMC-1 cells. It also influenced phosphotyrosine signalling and KIT tyrosine autophosphorylation. CADM1 accounted for 46% of surface KIT levels and 31% of F-actin in HMC-1 cells. CADM1 downregulation resulted in elongation of cortical actin filaments in both HMC-1 cells and human lung MCs and increased cell rigidity of HMC-1 cells. Collectively these data suggest that CADM1 is a key adhesion receptor, which regulates MC net adhesion, both directly through CADM1-dependent adhesion, and indirectly through the regulation of other adhesion receptors. The latter is likely to occur via docking of KIT and polymerisation of cortical F-actin. Here we propose a stepwise model of adhesion with CADM1 as a driving force for net MC adhesion.

  1. Cadherin-Based Intercellular Adhesions Organize Epithelial Cell-Matrix Traction Forces

    Mertz, Aaron F; Banerjee, Shiladitya; Goldstein, Jill; Rosowski, Kathryn R; Niessen, Carien M; Marchetti, M Cristina; Dufresne, Eric R; Horsley, Valerie

    2012-01-01

    Cell--cell and cell-matrix adhesions play essential roles in the function of tissues. There is growing evidence for the importance of crosstalk between these two adhesion types, yet little is known about the impact of these interactions on the mechanical coupling of cells to the extracellular-matrix (ECM). Here, we combine experiment and theory to reveal how intercellular adhesions modulate forces transmitted to the ECM. In the absence of cadherin-based adhesions, primary mouse keratinocytes within a colony appear to act independently, with significant traction forces extending throughout the colony. In contrast, with strong cadherin-based adhesions, keratinocytes in a cohesive colony localize traction forces to the colony periphery. Through genetic or antibody-mediated loss of cadherin expression or function, we show that cadherin-based adhesions are essential for this mechanical cooperativity. A minimal physical model in which cell--cell adhesions modulate the physical cohesion between contractile cells is ...

  2. Effect of gamma-irradiation on some microbial, organoleptic and chemical aspects of fresh meat, ground beef and beef burgers stored at 5 degree

    The effect of gamma-irradiation on the microbial aspects, organoleptic quality and chemical composition of fresh beef, ground beef, and beef burgers were investigated. High bacterial counts were recorded for beef burger samples than fresh and ground beef. Treatment with gamma radiation at doses of 1.0 and 1.50 Kgy, resulted in an immediate reduction in total bacterial numbers during 2 weeks of storage at 5 degree C. No pseudomonal-like organisms survived irradiation (0.50-1.50 Kgy). The 1.50 kGy treated samples were judged brighter (redder) in surface colour than raw (unirradiated) and irradiation did not affect the internal colour until the end of storage (day 15).Spoilage odours were not detected in 1.50 kGy-treated samples after 15 days of storage at 5 degree. However, irradiation odours were detectable at 1.0 and 1.50-kGy levels, when samples were exposed to air. Irradiation did not cause an increase in free fatty acids but significantly increased the peroxide values in fresh, ground beef and burgers stored at 5 degree for 2 weeks

  3. Denture Adhesives - A Literature Review

    Sudhanshu Shekhar

    2016-06-01

    Full Text Available Successful complete denture treatment combines exemplary technique, effective patient rapport and education and familiarity with all possible management options to provide the highest degree of patient satisfaction. Dentists need to know about denture adhesives to be able to identify those patients who actually need them and to be able to educate them about the advantages, disadvantages and correct use of these products. Denture adhesives are commercially available nontoxic, soluble materials that when applied to the tissue surface of dentures enhance their retention, stability and performance. They were introduced in dentistry in the late 18th century. The first patent related to adhesives was issued in 1913, followed in the 1920’s and 1930’s. The purpose of the use of denture adhesives can be described as to subjectively benefit denture-wearers with improved stability, retention and comfort of their dentures, and with improved incisal force, masticatory ability, and confidence.

  4. The effect of adhesive layer elasticity on the fracture mechanics of a blister test specimen

    Updike, D. P.

    1975-01-01

    An analytical model of a blister type specimen for evaluating adhesive bond strength was developed. Plate theory with shear deformation was used to model the deformation of the plate, and elastic deformation of the adhesive layer is taken into account. It is shown that the inclusion of the elastic deformation of the adhesive layer can have a significant influence in the energy balance calculations of fracture mechanics.

  5. Laser surface modification and adhesion

    Mittal, K L

    2014-01-01

    The book provides a unique overview on laser techniques and applications for the purpose of improving adhesion by altering surface chemistry and topography/morphology of the substrate. It details laser surface modification techniques for a wide range of industrially relevant materials (plastics, metals, ceramics, composites) with the aim to improve and enhance their adhesion to other materials. The joining of different materials is of critical importance in the fabrication of many and varied products.

  6. Notch-Mediated Cell Adhesion

    Akihiko Murata; Shin-Ichi Hayashi

    2016-01-01

    Notch family members are generally recognized as signaling molecules that control various cellular responses in metazoan organisms. Early fly studies and our mammalian studies demonstrated that Notch family members are also cell adhesion molecules; however, information on the physiological roles of this function and its origin is limited. In this review, we discuss the potential present and ancestral roles of Notch-mediated cell adhesion in order to explore its origin and the initial roles of...

  7. Adhesive capsulitis: a case report

    Kazemi, Mohsen

    2000-01-01

    Adhesive capsulitis or frozen shoulder is an uncommon entity in athletes. However, it is a common cause of shoulder pain and disability in the general population. Although it is a self limiting ailment, its rather long, restrictive and painful course forces the affected person to seek treatment. Conservative management remains the mainstay treatment of adhesive capsulitis. This includes chiropractic manipulation of the shoulder, therapeutic modalities, mobilization, exercise, soft tissue ther...

  8. Adhesion hysteresis of a film-terminated fibrillar array

    Yan, ShunPing; He, LingHui; Wang, HuiJing

    2012-06-01

    Motivated by the recent biomimic design of microstructured adhesive surfaces, we study adhesion between a film-terminated fibrillar array and a rigid substrate. Using a two-dimensional model and ignoring the deformation of the fibers and the backing layer, we show that the adhesion behavior is dominated by a dimensionless parameter reflecting the global flexibility of the terminal film. In particular, if the parameter is larger than 0.4, the adhesion is reversible; otherwise one or more hysteresis loops will appear after an approach-retraction cycle, leading to significant increase in the specific separation work. The result is expected to help not only optimal design of the structure, but also other applications such as micro-manipulation in micromechanical systems.

  9. Adhesion at WC/diamond interfaces - A theoretical study

    We investigate the adhesion at the interface of face-centered tungsten-carbide (001) and diamond (001) from density-functional calculations. Four high-symmetry model interfaces, representing different lattice orientations for either side of the interface, are constructed to incorporate different degrees of strain arising due to lattice mismatch. The adhesion, estimated from the ideal work of separation, is found to be in the range of 4 - 7 J m−2 and is comparable to that of metal-carbide interfaces. Maximum adhesion occurs when WC and diamond slabs have the same orientation, even though such a growth induces large epitaxial strain at the interface. From electronic structure calculations, we attribute the adhesion to covalent interaction between carbon p-orbitals as well as partial ionic interaction between the tungsten d- and carbon p-orbitals across the interface

  10. ADHESION STRENGTH OF COATING SUBSTRATE AND SURFACE MORPHOLOGY OF PRETREATMENT

    2003-01-01

    Premature failure of coated tool often results from a poor adhesion of coating-substrate and shortens the lifetime of the tool.The results of increasing the adhesion strength of thin film coatings on cutting tool inserts by pretreating the inserts with sandblasting technique to obtain a desirable surface morphology of the inserts are presented.A geometric model representing the ideal surface morphology is established to enhance the nucleation density and adhesion strength of coating-substrate.Thin film coating experiment is conducted on the substrates of four different sample groups.Indentation and wear tests are performed on coated inserts to evaluate the effect of sandblasting on the adhesion strength of the coatings.A theoretical analysis is provided on the formation and growth of atom clusters in terms of the contact angle and the thermodynamic barrier of a substrate to predict thin film nucleation.

  11. Adhesion Dynamics in Probing Micro- and Nanoscale Thin Solid Films

    Xiaoling He

    2008-01-01

    Full Text Available This study focuses on modeling the probe dynamics in scratching and indenting thin solid films at micro- and nanoscales. The model identifies bifurcation conditions that define the stick-slip oscillation patterns of the tip. It is found that the local energy fluctuations as a function of the inelastic deformation, defect formation, material properties, and contact parameters determine the oscillation behavior. The transient variation of the localized function makes the response nonlinear at the adhesion junction. By quantifying the relation between the bifurcation parameters and the oscillation behavior, this model gives a realistic representation of the complex adhesion dynamics. Specifically, the model establishes the link between the stick-slip behavior and the inelastic deformation and the local potentials. This model justifies the experimental observations and the molecular dynamics simulation of the adhesion and friction dynamics in both the micro- and nanoscale contact.

  12. Pressure sensitive microparticle adhesion through biomimicry of the pollen-stigma interaction.

    Lin, Haisheng; Qu, Zihao; Meredith, J Carson

    2016-03-21

    Many soft biomimetic synthetic adhesives, optimized to support macroscopic masses (∼kg), have been inspired by geckos, insects and other animals. Far less work has investigated bioinspired adhesion that is tuned to micro- and nano-scale sizes and forces. However, such adhesive forces are extremely important in the adhesion of micro- and nanoparticles to surfaces, relevant to a wide range of industrial and biological systems. Pollens, whose adhesion is critical to plant reproduction, are an evolutionary-optimized system for biomimicry to engineer tunable adhesion between particles and micro-patterned soft matter surfaces. In addition, the adhesion of pollen particles is relevant to topics as varied as pollinator ecology, transport of allergens, and atmospheric phenomena. We report the first observation of structurally-derived pressure-sensitive adhesion of a microparticle by using the sunflower pollen and stigma surfaces as a model. This strong, pressure-sensitive adhesion results from interlocking between the pollen's conical spines and the stigma's receptive papillae. Inspired by this behavior, we fabricated synthetic polymeric patterned surfaces that mimic the stigma surface's receptivity to pollen. These soft mimics allow the magnitude of the pressure-sensitive response to be tuned by adjusting the size and spacing of surface features. These results provide an important new insight for soft material adhesion based on bio-inspired principles, namely that ornamented microparticles and micro-patterned surfaces can be designed with complementarity that enable a tunable, pressure-sensitive adhesion on the microparticle size and length scale. PMID:26883733

  13. Adhesion of Spores of Bacillus thuringiensis on a Planar Surface

    Chung, Eunhyea [Georgia Institute of Technology; Kweon, Hyojin [Georgia Institute of Technology; Yiacoumi, Sotira [Georgia Institute of Technology; Lee, Ida [University of Tennessee, Knoxville (UTK); Joy, David Charles [ORNL; Palumbo, Anthony Vito [ORNL; Tsouris, Costas [ORNL

    2010-01-01

    Adhesion of spores of Bacillus thuringiensis (Bt) and spherical silica particles on surfaces was experimentally and theoretically investigated in this study. Topography analysis via atomic force microscopy (AFM) and electron microscopy indicates that Bt spores are rod shaped, {approx}1.3 {mu}m in length and {approx}0.8 {mu}m in diameter. The adhesion force of Bt spores and silica particles on gold-coated glass was measured at various relative humidity (RH) levels by AFM. It was expected that the adhesion force would vary with RH because the individual force components contributing to the adhesion force depend on RH. The adhesion force between a particle and a planar surface in atmospheric environments was modeled as the contribution of three major force components: capillary, van der Waals, and electrostatic interaction forces. Adhesion force measurements for Bt spore (silica particle) and the gold surface system were comparable with calculations. Modeling results show that there is a critical RH value, which depends on the hydrophobicity of the materials involved, below which the water meniscus does not form and the contribution of the capillary force is zero. As RH increases, the van der Waals force decreases while the capillary force increases to a maximum value.

  14. Spatial chaos in weakly dispersive and viscous media a nonperturbative theory of the driven KdV-Burgers equation

    Malkov, M A

    1996-01-01

    The asymptotic travelling wave solution of the KdV-Burgers equation driven by the long scale periodic driver is constructed. The solution represents a shock-train in which the quasi-periodic sequence of dispersive shocks or soliton chains is interspersed by smoothly varying regions. It is shown that the periodic solution which has the spatial driver period undergoes period doublings as the governing parameter changes. Two types of chaotic behavior are considered. The first type is a weak chaos, where only a small chaotic deviation from the periodic solution occurs. The second type corresponds to the developed chaos where the solution ``ignores'' the driver period and represents a random sequence of uncorrelated shocks. In the case of weak chaos the shock coordinate being repeatedly mapped over the driver period moves on a chaotic attractor, while in the case of developed chaos it moves on a repellor. Both solutions depend on a parameter indicating the reference shock position in the shock-train. The structure...

  15. Unveiling the significance of eigenvectors in diffusing non-Hermitian matrices by identifying the underlying Burgers dynamics

    Burda, Zdzislaw, E-mail: zdzislaw.burda@agh.edu.pl [AGH University of Science and Technology, Faculty of Physics and Applied Computer Science, al. Mickiewicza 30, PL-30059 Kraków (Poland); Grela, Jacek, E-mail: jacekgrela@gmail.com [M. Smoluchowski Institute of Physics and Mark Kac Complex Systems Research Centre, Jagiellonian University, PL-30348 Kraków (Poland); Nowak, Maciej A., E-mail: nowak@th.if.uj.edu.pl [M. Smoluchowski Institute of Physics and Mark Kac Complex Systems Research Centre, Jagiellonian University, PL-30348 Kraków (Poland); Tarnowski, Wojciech, E-mail: wojciech.tarnowski@uj.edu.pl [M. Smoluchowski Institute of Physics and Mark Kac Complex Systems Research Centre, Jagiellonian University, PL-30348 Kraków (Poland); Warchoł, Piotr, E-mail: piotr.warchol@uj.edu.pl [M. Smoluchowski Institute of Physics and Mark Kac Complex Systems Research Centre, Jagiellonian University, PL-30348 Kraków (Poland)

    2015-08-15

    Following our recent letter, we study in detail an entry-wise diffusion of non-hermitian complex matrices. We obtain an exact partial differential equation (valid for any matrix size N and arbitrary initial conditions) for evolution of the averaged extended characteristic polynomial. The logarithm of this polynomial has an interpretation of a potential which generates a Burgers dynamics in quaternionic space. The dynamics of the ensemble in the large N limit is completely determined by the coevolution of the spectral density and a certain eigenvector correlation function. This coevolution is best visible in an electrostatic potential of a quaternionic argument built of two complex variables, the first of which governs standard spectral properties while the second unravels the hidden dynamics of eigenvector correlation function. We obtain general formulas for the spectral density and the eigenvector correlation function for large N and for any initial conditions. We exemplify our studies by solving three examples, and we verify the analytic form of our solutions with numerical simulations.

  16. Unveiling the significance of eigenvectors in diffusing non-Hermitian matrices by identifying the underlying Burgers dynamics

    Zdzislaw Burda

    2015-08-01

    Full Text Available Following our recent letter [1], we study in detail an entry-wise diffusion of non-hermitian complex matrices. We obtain an exact partial differential equation (valid for any matrix size N and arbitrary initial conditions for evolution of the averaged extended characteristic polynomial. The logarithm of this polynomial has an interpretation of a potential which generates a Burgers dynamics in quaternionic space. The dynamics of the ensemble in the large N limit is completely determined by the coevolution of the spectral density and a certain eigenvector correlation function. This coevolution is best visible in an electrostatic potential of a quaternionic argument built of two complex variables, the first of which governs standard spectral properties while the second unravels the hidden dynamics of eigenvector correlation function. We obtain general formulas for the spectral density and the eigenvector correlation function for large N and for any initial conditions. We exemplify our studies by solving three examples, and we verify the analytic form of our solutions with numerical simulations.

  17. Unveiling the significance of eigenvectors in diffusing non-Hermitian matrices by identifying the underlying Burgers dynamics

    Following our recent letter, we study in detail an entry-wise diffusion of non-hermitian complex matrices. We obtain an exact partial differential equation (valid for any matrix size N and arbitrary initial conditions) for evolution of the averaged extended characteristic polynomial. The logarithm of this polynomial has an interpretation of a potential which generates a Burgers dynamics in quaternionic space. The dynamics of the ensemble in the large N limit is completely determined by the coevolution of the spectral density and a certain eigenvector correlation function. This coevolution is best visible in an electrostatic potential of a quaternionic argument built of two complex variables, the first of which governs standard spectral properties while the second unravels the hidden dynamics of eigenvector correlation function. We obtain general formulas for the spectral density and the eigenvector correlation function for large N and for any initial conditions. We exemplify our studies by solving three examples, and we verify the analytic form of our solutions with numerical simulations

  18. Plasma polymerization for cell adhesive/anti-adhesive implant coating

    Meichsner, Juergen; Testrich, Holger; Rebl, Henrike; Nebe, Barbara

    2015-09-01

    Plasma polymerization of ethylenediamine (C2H8N2, EDA) and perfluoropropane (C3F8, PFP) with admixture of argon and hydrogen, respectively, was studied using an asymmetric 13.56 MHz CCP. The analysis of the plasma chemical gas phase processes for stable molecules revealed consecutive reactions: C2H8N2 consumption, intermediate product NH3, and main final product HCN. In C3F8- H2 plasma the precursor molecule C3F8 and molecular hydrogen are consumed and HF as well as CF4 and C2F6 are found as main gaseous reaction products. The deposited plasma polymer films on the powered electrode are strongly cross-linked due to ion bombardment. The stable plasma polymerized films from EDA are characterized by high content of nitrogen with N/C ratio of about 0.35. The plasma polymerized fluorocarbon film exhibit a reduced F/C ratio of about 1.2. Adhesion tests with human osteoblast cell line MG-63 on coated Ti6Al4V samples (polished) compared with uncoated reference sample yielded both, the enhanced cell adhesion for plasma polymerized EDA and significantly reduced cell adhesion for fluorocarbon coating, respectively. Aging of the plasma polymerized EDA film, in particular due to the reactions with oxygen from air, showed no significant change in the cell adhesion. The fluorocarbon coating with low cell adhesion is of interest for temporary implants. Funded by the Campus PlasmaMed.

  19. Finite element analysis of multi-piece post-crown restoration using different types of adhesives

    Lin-Wei Lu; Guang-Wei Meng; Zhi-Hui Liu

    2013-01-01

    The multi-piece post-crown technique is more effective in restoring residual root than other restoration techniques. Various types of adhesives have different material properties that affect restoration. Therefore, the choice of adhesive is particularly important for patients. However, the effect of different kinds of adhesives was not too precise by experimental methods when concerning about individual differences of teeth. One tooth root can only be restored with one type of adhesive in experiment. After the mechanical test, this tooth root cannot be restored with other adhesives. With the help of medical imaging technology, reverse engineering and finite element analysis, a molar model can be reconstructed precisely and restored using different types of adhesives. The same occlusal and chewing loads were exerted on the same restored residual root models with different types of adhesives separately. Results of von Mises stress analysis showed that the adhesives with low Young’s modulus can protect the root canal effectively. However, a root canal concentration is apparently produced around the root canal orifice when chewing. Adhesives with large Young’s modulus can buffer the stress concentration of the root canal orifice. However, the root canal tissue may be destroyed because the adhesive is too hard to buffer the load.

  20. Innovative Electrostatic Adhesion Technologies

    Bryan, Tom; Macleod, Todd; Gagliano, Larry; Williams, Scott; McCoy, Brian

    2015-01-01

    Developing specialized Electro-Static grippers (commercially used in Semiconductor Manufacturing and in package handling) will allow gentle and secure Capture, Soft Docking, and Handling of a wide variety of materials and shapes (such as upper-stages, satellites, arrays, and possibly asteroids) without requiring physical features or cavities for a pincher or probe or using harpoons or nets. Combined with new rigid boom mechanisms or small agile chaser vehicles, flexible, high speed Electro-Static Grippers can enable compliant capture of spinning objects starting from a safe stand-off distance. Electroadhesion (EA) can enable lightweight, ultra-low-power, compliant attachment in space by using an electrostatic force to adhere similar and dissimilar surfaces. A typical EA enabled device is composed of compliant space-rated materials, such as copper-clad polyimide encapsulated by polymers. Attachment is induced by strong electrostatic forces between any substrate material, such as an exterior satellite panel and a compliant EA gripper pad surface. When alternate positive and negative charges are induced in adjacent planar electrodes in an EA surface, the electric fields set up opposite charges on the substrate and cause an electrostatic adhesion between the electrodes and the induced charges on the substrate. Since the electrodes and the polymer are compliant and can conform to uneven or rough surfaces, the electrodes can remain intimately close to the entire surface, enabling high clamping pressures. Clamping pressures of more than 3 N/cm2 in shear can be achieved on a variety of substrates with ultra-low holding power consumption (measured values are less than 20 microW/Newton weight held). A single EA surface geometry can be used to clamp both dielectric and conductive substrates, with slightly different physical mechanisms. Furthermore EA clamping requires no normal force be placed on the substrate, as conventional docking requires. Internally funded research and