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Sample records for added punica granatum

  1. Constituents of the flowers of Punica granatum.

    Wang, Rufeng; Wei Wang; Wang, Liang; Liu, Ruining; Yi Ding; Du, Lijun

    2006-12-01

    A new polyphenol compound named pomegranatate (1), together with, ellagic acid, 3,3',4'-tri-O-methylellagic acid, ethyl brevifolincarboxylate, urolic and maslinic acids, and daucosterol were isolated from the ethanolic extract of the flowers of Punica granatum. The structure of compound 1 was determined by spectroscopic analysis. Maslinic acid exhibited antioxidant activity, evaluated by measurement of LDL susceptibility to oxidation. PMID:16887296

  2. Anthocyanins from pomegranate (Punica granatum L.)

    Cabrita, Luís; Neves, Higuinaldo Chaves das

    2002-01-01

    The anthocyanin contents in the fruits from three cultivars of Punica granatum L. (asseria, mollar and negral) was studied. Six anthocyanins were isolated from the red seeds of pomegranate fruits using a combination of Sephadex LH-20 column chromatography and reverse-phase semi-preparative HPLC. On the basis of chromatographic and spectroscopic techniques, they were identified as the 3-monoglucosides and 3,5-diglucosides of delphinidin, cyanidin and pelargonidin. Total anthocyanin content in...

  3. DETERMINATION OF ANTIBACTERIAL ACTIVITY OF PUNICA GRANATUM FRUIT

    P. P. Lasure*, N. M. Munot and S. S. Lawande

    2012-01-01

    Punica granatum L. belongs to the family Punicaceae, which is originating from the Middle East, extending throughout the Mediterranean, eastward to China and India. Punica granatum has been used extensively as a traditional medicine in many countries for the treatment of dysentery, diarrhea, helminthiasis, acidosis, hemorrhage and respiratory pathologies. In addition, P. granatum is reported to have antioxidant, anti-atherosclerotic and antiviral properties. The dried pomegranate peels (20gms...

  4. Effect of added Punica granatum peel fruits and Nigella sativa seeds on immunology and performance of suckling buffalo calves

    The use of feed additives is considered as a good source to improve the immunity status of newborn calves instead of chemical products because the residuals of chemical products may have side effects on human health on the long-run. Punica granatum fruits peel (Pg-p) has been shown to possess a significant antioxidant activity also valued for their therapeutic properties and used to remove intestinal tapeworm. On the other hand, seeds of Nigella sativa (NS) are rich in fatty acids (Linoleic and Linolenic acid), essential fatty acids and non-starch polysaccharide. Recently, clinical and animal studies have shown that extract of the NS seeds have many therapeutic effects such as immunomodilative, antibacterial, hypotensive, hepatoprotective, and antidiabetic effects. Thirty-six suckling buffalo claves (18 males and 18 females) were used in this study with average live body weight 38.44 ± 0.62 kg. The calves were divided into 3 groups, each group allotted to receive one of 3 tested starters throughout 105 d. The starter was offered without additive in the control group (G1), while it was mixed with 2% Pg-p in group (G2) and with 2% Pg-p plus 3% NS in group (G3). Weekly faecal swabs were collected from the experimental animals for bacteriological examination. Immunoglobulins (Ig) and blood metabolites were determined in blood serum. Three sets of digestion trials were carried out using 3 male calves of each group that fed the same tested rations. Milk consumption was not significantly different among groups while, starter and clover hay intake was significantly (P < 0.05) higher in G3 than those in groups G1 and G2. The total weight gain achieved by group G3 was greater than that of G1 and G2 groups by 25.60% and 7.80%, respectively. Blood TP was significantly (P < 0.05) higher in G3 than that in G1. An albumin value was relatively higher in G1 compared with the treated G2 and G3. Meanwhile, blood urea nitrogen was significantly greater in G2 in comparison with G1 and

  5. A Review Study on Punica granatum L.

    Shaygannia, Erfaneh; Bahmani, Mahmoud; Zamanzad, Behnam; Rafieian-Kopaei, Mahmoud

    2016-07-01

    Punica granatum L (pomegranate) is a deciduous shrub, native to Iran. Nowadays, besides its use as a fruit, its medicinal properties have attracted the interest of researchers of many countries. Pomegranate fruit has medicinal properties such as anti-inflammatory and antibacterial activities. The pomegranate seed oil has inhibitory effect on skin and breast cancers. The pomegranate seed oil has phytoestrogenic compounds and the fruit is rich in phenolic compounds with strong antioxidant activity. Ellagic acid is one of the main components of pomegranate with phenolic structure and antioxidant activity. This review article presents the recently published findings on different aspects of this plant focusing on its medicinal properties. PMID:26232244

  6. Ultrasound assisted extraction of polyphenols from Punica granatum (Grenada) fruit

    Extraction of bioactive compounds from vegetable materials is a classical operation applied in many industrial processes. Few studies have made reference to processes to obtain extracts from Punica granatum. This fruit is generally consumed as such or as fermented juices. In Cuba, it is known as grenade and numerous studies have shown antiviral, antioxidant and antimicrobial properties. Maceration process is the main used technology in the preparation of extracts from Punica granatum fruit, being this a long and expensive process. Ultrasound-assisted extractions have been proven to significantly decreased extraction time and increased extraction yields in many vegetable materials. However, few papers report the use of this methodology in the extraction processes of Punica granatum. To evaluate an ultrasound-assisted extraction process to extract polyphenols from Punica granatum fruit

  7. Punica granatum: A New Host of Bipolaris spicifera in Morocco

    Oumama Kadri; Rachid Benkirane; Amina Ouazzani Touhami; Allal Douira

    2011-01-01

    During March 2009 in the public gardens and the University of Sciences of Kenitra city (Morocco), 60% of leaves of 100 plants of pomegranate (Punica granatum L. ’Nana’) presented foliar lesions that affecting the aesthetic appearance of this ornamental plant. Bipolaris spicifera was isolated from ten necrotic lesions of 25 leaves. The artificial inoculation of the healthy leaves of three plants of Punica granatum L. ’Nana’ by conidial suspension of the pathogen induced the same lesions to tha...

  8. Determination of Bioactive Components of Ethyl Acetate Fraction of Punica granatum Rind Extract

    J. Sangeetha; Vijayalakshmi, K.

    2011-01-01

    Punica granatum belongs to a Punicaceae family. The Punica granatum is valued as a powerful medicinal plant and used in folk medicines. Hence the present investigation was carried out to determine the possible chemical components from ethyl acetate fraction of Punica granatum rind extract by GC-MS Technique. This analysis revealed that ethyl acetate fraction of Punica granatum rind extract contain Pyrogallol (41.88%), 5-Hydroxymethylfurfural (14.10%), D-Allose (9.17%), 2-Methoxy-1, 4-Benzened...

  9. Molluscicidal activity of Punica granatum bark and Canna indica root

    Tripathi, S.M.; Singh, D.K.

    2000-01-01

    The molluscicidal activity of Punica granatum Linn. (Punicaceae) and Canna indica Linn. (Cannaceae) against the snail Lymnaea acuminata was studied. The molluscicidal activity of P. granatum bark and C. indica root was found to be both time and dose dependent. The toxicity of P. granatum bark was more pronounced than that of C. indica. The 24 h LC50 of the column-purified root of C. indica was 6.54 mg/l whereas that of the column-purified bark of P. granatum was 4.39 mg/l. The ethanol extract...

  10. Analgesic activity of various extracts of Punica granatum (Linn flowers

    Chakraborthy Guno

    2008-01-01

    Full Text Available The extracts of flowers of Punica granatum (Linn. (N.O. Family Punicaceae were investigated for analgesic activity in mice using hot plate method. The flowers of Punica granatum (Linn were collected from the local market of Mumbai, Maharashtra and were in a dried condition. The dried powdered flowers (500 gm were extracted in a soxhlet apparatus by using different solvents. Mice weighing 15-25 gm were taken for the experiment. The reaction time of animals in all the groups was noted at 30, 60 and 120 min after drug administration. All data were analyzed with Student-t test. The various extract of the flowers of Punica granatum (Linn showed significant analgesic activity at a dose of 50 mg/kg body weight. A maximum analgesic activity was found at 60 min, after drug administration, which was equivalent to the standard drug used as morphine sulphate.

  11. Isolation of Antidiabetic Principle from Fruit Rinds of Punica granatum

    Vishal Jain; G. L. Viswanatha; Manohar, D.; Shivaprasad, H. N.

    2012-01-01

    Present study was aimed to isolate and evaluate the antidiabetic activity of phytoconstituents from fruit rinds of Punica granatum. With the above objectives Valoneic acid dilactone (VAD) was isolated from methanolic fruit rind extracts of Punica granatum (MEPG) and confirmed by 1H-NMR, 13C-NMR, and mass spectral data. Antidiabetic activity was evaluated by Aldose reductase, α -amylase and PTP1B inhibition assays in in vitro and Alloxan-induced diabetes in rats was used as an in vivo model. I...

  12. Investigation of a betainic alkaloid from Punica granatum.

    Schmidt, Andreas; Mordhorst, Thorsten; Nieger, Martin

    2005-07-01

    Spectroscopic investigations reveal that a hydroquinone pyridinium alkaloid isolated from the leaves of pomegranates Punica granatum L. (X-ray) exists as a mixture of a conjugated and a cross-conjugated heterocyclic mesomeric betaine in aqueous and DMSO-d6 solution. Twofold deprotonation yields an anionic tripole. PMID:15938201

  13. Isolation and Characterization of Novel Microsatellite Markers in Pomegranate (Punica granatum L.)

    Pirseyedi, Seyed Mostafa; Valizadehghan, Sahar; Mardi, Mohsen; Ghaffari, Mohammad Reza; Mahmoodi, Parvaneh; Zahravi, Mehdi; Zeinalabedini, Mehrshad; Nekoui, Seyed Mojtaba Khayam

    2010-01-01

    Pomegranate (Punica granatum L.) has been cultivated from ancient times for its economic, ornamental and medicinal properties globally. Here, we report the isolation and characterization of 12 polymorphic microsatellite markers from a repeat-enriched genomic library of Punica granatum L. The genetic diversity of these loci was assessed in 60 genotypes of Punica granatum L. All loci were variable: the number of polymorphic alleles per locus ranged from two to five (average 2.9). The observed a...

  14. Determination of Bioactive Components of Ethyl Acetate Fraction of Punica granatum Rind Extract

    J. Sangeetha

    2011-04-01

    Full Text Available Punica granatum belongs to a Punicaceae family. The Punica granatum is valued as a powerful medicinal plant and used in folk medicines. Hence the present investigation was carried out to determine the possible chemical components from ethyl acetate fraction of Punica granatum rind extract by GC-MS Technique. This analysis revealed that ethyl acetate fraction of Punica granatum rind extract contain Pyrogallol (41.88%, 5-Hydroxymethylfurfural (14.10%, D-Allose (9.17%, 2-Methoxy-1, 4-Benzenediol (8.34% and 2, 3 Dimethylfumaric acid (3.96% justifying the use of this plant to treat many disease in folk and herbal medicine.

  15. Punica granatum: A New Host of Bipolaris spicifera in Morocco

    Oumama Kadri

    2011-01-01

    Full Text Available During March 2009 in the public gardens and the University of Sciences of Kenitra city (Morocco, 60% of leaves of 100 plants of pomegranate (Punica granatum L. ’Nana’ presented foliar lesions that affecting the aesthetic appearance of this ornamental plant. Bipolaris spicifera was isolated from ten necrotic lesions of 25 leaves. The artificial inoculation of the healthy leaves of three plants of Punica granatum L. ’Nana’ by conidial suspension of the pathogen induced the same lesions to that observed in nature. The diseased foliar surface and the total number of diseased leaves 30 days after inoculation with B. spicifera conidial suspension were 37.5% and 78. Conidia production of B. spicifera on inoculated leaves was 0.81 x 105 spore cm-2 and the fungus was re-isolated from lesions on inoculated plants. This is the first report of B. spicifera on pomegranate in Morocco.

  16. PUNICA GRANATUM ATTENUATES SCIATIC NERVE LIGATION INDUCED-NEUROPATHIC PAIN

    Ramica Sharma et al.

    2012-01-01

    The study has been designed to investigate the effect of aqueous extract of rind of Punica granatum in sciatic nerve ligation induced-neuropathic pain in rats. Surgical procedure was performed with sciatic nerve ligation to develop neuropathic pain in rats. The development of neuropathic pain was assessed by employing behaviour parameters such as hyperalgesia and allodynia. Further, the functionality of sciatic nerve was assessed using the histopathological study of myelinated and unmyelinate...

  17. PUNICA GRANATUM: A REVIEW ON PHARMACOLOGICAL AND THERAPEUTIC PROPERTIES

    Neelam Arun* and D. P. Singh

    2012-01-01

    A wide range of medicinal plant parts is used as raw drugs and they possess varied medicinal properties. The different parts used as raw drugs include root, stem, flower, fruit, twigs exudates and modified plant organs. The Punica granatum is a native shrub of occidental Asia and Mediterranean Europe that has a rich history of traditional use in medicine. For centuries, the barks, leaves, flowers, fruits, and seeds of this plant have been used to treat various diseases. The aim of this presen...

  18. PUNICA GRANATUM ATTENUATES SCIATIC NERVE LIGATION INDUCED-NEUROPATHIC PAIN

    Ramica Sharma et al.

    2012-02-01

    Full Text Available The study has been designed to investigate the effect of aqueous extract of rind of Punica granatum in sciatic nerve ligation induced-neuropathic pain in rats. Surgical procedure was performed with sciatic nerve ligation to develop neuropathic pain in rats. The development of neuropathic pain was assessed by employing behaviour parameters such as hyperalgesia and allodynia. Further, the functionality of sciatic nerve was assessed using the histopathological study of myelinated and unmyelinated fibers in sciatic nerve. Moreover, the oxidative stress was assessed by estimating serum thiobarbituric acid reactive substances (TBARS, catalase, glutathione and tissue TBARS and Superoxide dismutase (SOD. Rats exposed to sciatic nerve ligation produced marked increase in oxidative stress, which was assessed in terms of TBARS and SOD along with decrease in the level of catalase and glutathione. Moreover, it develops neuropathic pain by impairing the normal functions of myelinated and unmyelinated fibers in sciatic nerve. Treatment with aqueous extract of Punica granatum extract (100mg/kg, p.o markedly prevented sciatic nerve ligation-induced neuropathy and oxidative stress by increasing the pain threshold, by improving the functionality of sciatic nerve, by decreasing serum and tissue TBARS and tissue SOD, by increasing levels of serum glutathione and catalase. It may be concluded that Punica granatum extract reduced the oxidative stress via inhibiting p38MAPK and alleviates neuropathic symptoms and consequently improved the functionality of sciatic nerve and prevents sciatic nerve ligation–induced neuropathic pain.

  19. Molluscicidal activity of Punica granatum bark and Canna indica root.

    Tripathi, S M; Singh, D K

    2000-11-01

    The molluscicidal activity of Punica granatum Linn. (Punicaceae) and Canna indica Linn. (Cannaceae) against the snail Lymnaea acuminata was studied. The molluscicidal activity of P. granatum bark and C. indica root was found to be both time and dose dependent. The toxicity of P. granatum bark was more pronounced than that of C. indica. The 24 h LC(50) of the column-purified root of C. indica was 6.54 mg/l whereas that of the column-purified bark of P. granatum was 4.39 mg/l. The ethanol extract of P. granatum (24 h LC(50): 22.42 mg/l) was more effective than the ethanol extract of C. indica (24 h LC(50): 55.65 mg/l) in killing the test animals. P. granatum and C. indica may be used as potent molluscicides since the concentrations used to kill the snails were not toxic for the fish Colisa fasciatus, which shares the same habitat with the snail L. acuminata. PMID:11050667

  20. Molluscicidal activity of Punica granatum bark and Canna indica root

    Tripathi S.M.

    2000-01-01

    Full Text Available The molluscicidal activity of Punica granatum Linn. (Punicaceae and Canna indica Linn. (Cannaceae against the snail Lymnaea acuminata was studied. The molluscicidal activity of P. granatum bark and C. indica root was found to be both time and dose dependent. The toxicity of P. granatum bark was more pronounced than that of C. indica. The 24 h LC50 of the column-purified root of C. indica was 6.54 mg/l whereas that of the column-purified bark of P. granatum was 4.39 mg/l. The ethanol extract of P. granatum (24 h LC50: 22.42 mg/l was more effective than the ethanol extract of C. indica (24 h LC50: 55.65 mg/l in killing the test animals. P. granatum and C. indica may be used as potent molluscicides since the concentrations used to kill the snails were not toxic for the fish Colisa fasciatus, which shares the same habitat with the snail L. acuminata.

  1. Growth-Inhibitory and Apoptosis-Inducing Effects of Punica granatum L. var. spinosa (Apple Punice) on Fibrosarcoma Cell Lines

    Sineh sepehr, Koushan; Baradaran, Behzad; Mazandarani, Masoumeh; Yousefi, Bahman; Abdollahpour Alitappeh, Meghdad; Khori, Vahid

    2014-01-01

    Purpose: Punica granatum L. var. granatum (Pomegranate), an herbaceous plant found in Iran, The aim of this study was to investigate the cytotoxic effects, induction of apoptosis, and the mechanism of cell death of ethanol extract from Punica granatum L. var. spinosa on the mouse fibrosarcoma cell line, WEHI-164.

  2. Fatty acid synthase inhibitors isolated from Punica granatum L

    Jiang, He-Zhong [School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, (China); Ma, Qing-Yun; Liang, Wen-Juan; Huang, Sheng-Zhuo; Dai, Hao-Fu; Wang, Peng-Cheng; Zhao, You-Xing, E-mail: zhaoyx1011@163.com [Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou (China); Fan, Hui-Jin; Ma, Xiao-Feng, E-mail: maxiaofeng@gucas.ac.cn [College of Life Sciences, Graduate University of Chinese Academy of Sciences, Beijing (China)

    2012-05-15

    The aim of this work is the isolation of fatty acid synthase (FAS) inhibitors from the ethyl acetate extracts of fruit peels of Punica granatum L. Bioassay-guided chemical investigation of the fruit peels resulted in the isolation of seventeen compounds mainly including triterpenoids and phenolic compounds, from which one new oleanane-type triterpene (punicaone) along with fourteen known compounds were isolated for the first time from this plant. Seven isolates were evaluated for inhibitory activities of FAS and two compounds showed to be active. Particularly, flavogallonic acid exhibited strong FAS inhibitory activity with IC{sub 50} value of 10.3 {mu}mol L{sup -1}. (author)

  3. PUNICA GRANATUM: A REVIEW ON PHARMACOLOGICAL AND THERAPEUTIC PROPERTIES

    Neelam Arun* and D. P. Singh

    2012-05-01

    Full Text Available A wide range of medicinal plant parts is used as raw drugs and they possess varied medicinal properties. The different parts used as raw drugs include root, stem, flower, fruit, twigs exudates and modified plant organs. The Punica granatum is a native shrub of occidental Asia and Mediterranean Europe that has a rich history of traditional use in medicine. For centuries, the barks, leaves, flowers, fruits, and seeds of this plant have been used to treat various diseases. The aim of this present review is to throw light on the therapeutic utility of various parts of pomegranate.

  4. Fatty acid synthase inhibitors isolated from Punica granatum L

    The aim of this work is the isolation of fatty acid synthase (FAS) inhibitors from the ethyl acetate extracts of fruit peels of Punica granatum L. Bioassay-guided chemical investigation of the fruit peels resulted in the isolation of seventeen compounds mainly including triterpenoids and phenolic compounds, from which one new oleanane-type triterpene (punicaone) along with fourteen known compounds were isolated for the first time from this plant. Seven isolates were evaluated for inhibitory activities of FAS and two compounds showed to be active. Particularly, flavogallonic acid exhibited strong FAS inhibitory activity with IC50 value of 10.3 μmol L-1. (author)

  5. Topical microemulsion containing Punica granatum extract: its control over skin erythema and melanin in healthy Asian subjects

    Parveen, Rashida; Akhtar, Naveed; Mahmood, Tariq

    2014-01-01

    Introduction Punica granatum is apotent source of polyphenolic compounds with strong free radicals scavenging activity. The skin lightening effects of Punica granatum are assumed due to ellagic acid which acts by chelating copper at the active site of tyrosinase. Aim To explore a topical microemulsion (O/W) of pomegranate (Punica granatum) extract for its control on skin erythema and melanin. Material and methods Microemulsions were formulated using a polysorbate surfactant (Tween 80®) along ...

  6. Phytochemical screening and antibacterial activity of aqueous leaf extract of Punica granatum

    Manoj Kumar; Sukumar Dandapat; Manoranjan Prasad Sinha

    2015-01-01

    In the present study the leaves of Punica granatum were subjected to phytochemical screening and the impact of the leaf extract of Punica granatum was tested against Bacillus subtilis, Staphylococcus aureus and Salmonella typhi. The phytochemical analysis revealed the presence of various phytochemicals such as alkaloids, tannins, phenols, flavonoid and saponins. Agar disk diffusion method was employed to test the antibacterial activity and the result showed that the aquesous leaf extract o...

  7. Antibacterial and Antifungal Activities of Punica Granatum Peel Extracts Against Oral Pathogens

    Sh. Abdollahzadeh; RY. Mashouf; H. Mortazavi; MH. Moghaddam; N. Roozbahani; Vahedi, M.

    2011-01-01

    Objective: Punica granatum has been used for many years in folk medicine due to several purposes. The aim of the present study was to evaluate the effect of methanolic extract of Punica granatum peel (MEPGP) against Streptococcus mutans, Staphylococcus aureus, Streptococcus salivarius, Streptococcus sanguinis, Staphylococcus epidermidis, Actynomyces viscosus, Lactobacillus acidophilus and Candida albicans. Materials and Methods: In this in vitro study, the mentioned oral organisms were cultur...

  8. Punica Granatum Juice Effects on Oxidative Stress in Severe Physical Activity

    Naghizadeh-Baghi, Abbas; Mazani, Mohammad; Shadman-Fard, Ali; Nemati, Ali

    2015-01-01

    Aim: The aim of this study was to investigate Punica granatum juice effects on oxidative stress in young healthy males during severe physical activity. Methods: Our subjects were selected from healthy males at 18 - 24 years. They were enrolled and randomly distributed into control and supplemented groups. 240 ml of Punica granatum juice and tap water were given to supplement and control groups daily for two weeks, respectively. Fasting blood samples were taken at the starting and the end of t...

  9. EVALUATION OF ANTI-NOCICEPTIVE AND ANTI-INFLAMMATORY ACTIVITY OF PUNICA GRANATUM SEED EXTRACT

    Gupta Jeetendra Kumar; Sharma Sandeep Kumar; Misra Vimlesh; Patel Kanika

    2011-01-01

    The plant Punica granatum of family Punicaceae is distributed throughout India and reputed to have numerous applications in traditional medicine system. In order to justify its folkloric use in nociception and inflammation, the study was performed.In this study, the extraction of Punica granatum seed extract was carried out in aqueous media. In order to explore its potency, various experimental models of anti-nociceptive and anti-inflammatory activities were taken. The oral administration of ...

  10. ORGANOLEPTIC AND WORMICIDAL EVALUATION OF VARIOUS CRUDE EXTRACTS OF POMEGRANATE (PUNICA GRANATUM) PEEL

    Sikandar Khan Sherwani; Tasveer Zahra Bokhari; Yasmeen Bibi; Syed Aneel Gilani; Shahzad Munir; Muhammad Ajmal Shah; Ikramullah

    2013-01-01

    In the present study, organoleptic evaluation of Pomegranate (Punica granatum L) peel powder was done and found pink in color having no smell and slightly bitter taste. Moreover, aqueous and methanolic extracts of Pomegranate (Punica granatum L) peel were also prepared and investigated for their anthelmintic activity using a model worm i.e. Pheretima posthuma. Three concentrations (25, 50 and 100 mg / ml) of each extracts were studied in activity, which involved the determination of time of p...

  11. Cardioprotective potential of Punica granatum extract in isoproterenol-induced myocardial infarction in Wistar rats

    Mahalaxmi Mohan; Pankaj Patankar; Prakash Ghadi; Sanjay Kasture

    2010-01-01

    Objective: To determine the protective role of Punica granatum L. (Punicaceae) seed juice extract and its butanolic fraction on heart rate, electrocardiographic patterns, vascular reactivity to catecholamines, cardiac marker enzymes, antioxidant enzymes together with morphologic and histopathological changes in isoproterenol-induced myocardial infarction in male Wistar rats. Materials and Methods: The effects of Punica granatum seed juice extract (100 mg/kg, p.o. and 300 mg/kg, p.o.) and but...

  12. Antibacterial Effect of Hydroalcoholic Extract of Punica granatum Linn. Petal on Common Oral Microorganisms

    Farnaz Hajifattahi; Elham Moravej-Salehi; Maryam Taheri; Arash Mahboubi; Mohammad Kamalinejad

    2016-01-01

    Objectives. This study aimed to assess the effect of hydroalcoholic extract of Punica granatum Linn. (P. granatum) petal on Streptococcus sanguinis, Streptococcus mutans, Streptococcus salivarius, Streptococcus sobrinus, and Enterococcus faecalis. Materials and Methods. In this in vitro study, P. granatum extract was prepared using powdered petals and water-ethanol solvent. Antibacterial effect of the extract, chlorhexidine (CHX), and ampicillin was evaluated on brain heart infusion agar (BHI...

  13. Isolation of Antidiabetic Principle from Fruit Rinds of Punica granatum

    Vishal Jain

    2012-01-01

    Full Text Available Present study was aimed to isolate and evaluate the antidiabetic activity of phytoconstituents from fruit rinds of Punica granatum. With the above objectives Valoneic acid dilactone (VAD was isolated from methanolic fruit rind extracts of Punica granatum (MEPG and confirmed by 1H-NMR, 13C-NMR, and mass spectral data. Antidiabetic activity was evaluated by Aldose reductase, α-amylase and PTP1B inhibition assays in in vitro and Alloxan-induced diabetes in rats was used as an in vivo model. In bioactivity studies, MEPG and VAD have showed potent antidiabetic activity in α-amylase, aldose reductase, and PTP1B inhibition assays with IC50 values of 1.02, 2.050, 26.25 μg/mL and 0.284, 0.788, 12.41 μg/mL, respectively. Furthermore, in alloxan-induced diabetes model MEPG (200 and 400 mg/kg, p.o. and VAD (10, 25, and 50 mg/kg, p.o. have showed significant and dose dependent antidiabetic activity by maintaining the blood glucose levels within the normal limits. Inline with the biochemical findings histopathology of MEPG (200 and 400 mg/kg, p.o., VAD (10, 25, and 50 mg/kg, p.o., and glibenclamide (10 mg/kg, p.o. treated animals showed significant protection against alloxan-induced pancreatic tissue damage. These findings suggest that MEPG and VAD possess significant antidiabetic activity in both in vitro and in vivo models.

  14. Antibacterial activity of plant extracts against Xanthomonas axonopodis Pv. Punicae causing bacterial blight of Pomegranate (Punica granatum L.

    Alane S K

    2016-01-01

    Full Text Available Pomegranate (Punica granatum L. is the important fruit crop cultivated throughout the world. It is famous for its refreshing fruits. The crop is affected by ‘bacterial blight’ caused by Xanthomonas axonopodis pv. punicae, which is responsible for the failure of crop. It results in the dropping of leaves as well as fruits. It is very hard to manage the disease with chemicals as well as antibiotics and farmers suffer from heavy economic losses. In the present study, aqueous, ethyl alcohol and acetone extracts of ten medicinally useful plants were used against Xanthomonas axonopodis pv. punicae in vitro. The plant extracts showed antibacterial activity and caused inhibition of growth of Xanthomonas axonopodis pv. Punicae. Among them, Mentha spicata, Murraya Koeninngi, Allium sativum and Tridax procumbens caused maximum inhibition of the test bacterium.

  15. Analgesic activity of various extracts of Punica granatum (Linn) flowers

    Chakraborthy Guno

    2008-01-01

    The extracts of flowers of Punica granatum (Linn). (N.O. Family Punicaceae) were investigated for analgesic activity in mice using hot plate method. The flowers of Punica granatum (Linn) were collected from the local market of Mumbai, Maharashtra and were in a dried condition. The dried powdered flowers (500 gm) were extracted in a soxhlet apparatus by using different solvents. Mice weighing 15-25 gm were taken for the experiment. The reaction time of animals in all the groups was noted at 30...

  16. Bioactivity of Nonedible Parts of Punica granatum L.: A Potential Source of Functional Ingredients

    Nawraj Rummun; Jhoti Somanah; Srishti Ramsaha; Theeshan Bahorun; Vidushi S. Neergheen-Bhujun

    2013-01-01

    Punica granatum L. has a long standing culinary and medicinal traditional use in Mauritius. This prompted a comparative study to determine the bioefficacy of the flower, peel, leaf, stem, and seed extracts of the Mauritian P. granatum. The flower and peel extracts resulting from organic solvent extraction exhibited strong antioxidant activities which correlated with the high levels of total phenolics, flavonoids, and proanthocyanidins. The peel extract had the most potent scavenging capacity ...

  17. Protective Effect of Punica granatum on Ferric Nitrilotriacetate-Induced Toxicity in Oreochromis niloticus

    Piya KOSAI; Wipaphorn JAIKUA; Jiraungkoorskul, Kanitta; Wannee JIRAUNGKOORSKUL

    2015-01-01

    This study evaluates the efficiency of a dietary supplement of Punica granatum in reducing the toxicity of ferric nitrilotriacetate in Oreochromis niloticus, with emphasis on histopathological analysis. Fish were given a dietary supplement in doses of 0 (groups 1 and 2) and 60 mg g-1 of P. granatum (groups 3 and 4) for 28 days. After a time, fish in groups 2 and 4 received intraperitoneal injections of 9 mg kg-1 of ferric nitrilotriacetate. 24 hours after injection, histopathological lesions ...

  18. A Review on Antihyperglycemic and Antihepatoprotective Activity of Eco-Friendly Punica granatum Peel Waste

    Sushil Kumar Middha; Veena Pande; Talambedu Usha

    2013-01-01

    Over the past decade, pomegranate (Punica granatum) is entitled as a wonder fruit because of its voluminous pharmacological properties. In 1830, P. granatum fruit was first recognized in United States Pharmacopeia; the Philadelphia edition introduced the rind of the fruit, the New York edition the bark of the root and further 1890 edition the stem bark was introduced. There are significant efforts and progress made in establishing the pharmacological mechanisms of peel (pericarp or rind) and ...

  19. Molecular genetic diversity of Punica granatum L. (pomegranate) as revealed by microsatellite DNA markers

    Pomegranate (Punica granatum L.) is one of the oldest known edible fruits and more and more it arouse interest of scientific community given its numerous biological activities. However, information about its genetic resources and characterization using reliable molecular markers are still scarce. In...

  20. EVALUTION OF ANTIULCER ACTIVITY OF THE FLOWERS OF PUNICA GRANATUM EXPERIMENTAL ANIMALS

    Jabbar Zoobi; Ali Mohd

    2011-01-01

    Punica granatum L. (Punicaceae), commonly called pomegranate, is a shrub growing in the warm valleys and outer hills of the Himalayas and cultivated throughout India. The plant has been used in traditional system of medicine as antiulcerogenic, antidirrhoeal, antiworm, anticancer and neuroprotective drug.

  1. Cardioprotective potential of Punica granatum extract in isoproterenol-induced myocardial infarction in Wistar rats

    Mahalaxmi Mohan

    2010-01-01

    Full Text Available Objective: To determine the protective role of Punica granatum L. (Punicaceae seed juice extract and its butanolic fraction on heart rate, electrocardiographic patterns, vascular reactivity to catecholamines, cardiac marker enzymes, antioxidant enzymes together with morphologic and histopathological changes in isoproterenol-induced myocardial infarction in male Wistar rats. Materials and Methods: The effects of Punica granatum seed juice extract (100 mg/kg, p.o. and 300 mg/kg, p.o. and butanolic fraction of Punica granatum seed juice extract (100 mg/kg., p.o. on cardiac parameters were studied. Isoproterenol hydrochloride was used to induce myocardial infarction in Wistar rats. At the end of the experiment, heart rate, ECG, pressure rate index and cardiac marker enzyme levels were assessed. Results: Rats treated with isoproterenol (85 mg/kg, administered subcutaneously twice at an interval of 24 h showed a significant increase in heart rate, ST elevation in ECG, pressure rate index and a significant increase in the levels of cardiac marker enzymes- lactate dehydrogenase, and creatine kinase in serum. Isoproterenol significantly reduced superoxide dismutase and catalase activity and increased vascular reactivity to various catecholamines. Pretreatment with PJ (100 mg/kg, p.o. and 300 mg/kg, p.o. and B-PJ (100 mg/kg., p.o. for a period of 21 days significantly inhibited the effects of ISO on heart rate, PRI, ECG patterns, levels of LDH, CK, SOD, CAT, and vascular reactivity changes. Treatment with PJ (100 mg/kg and 300 mg/kg and B-PJ (100 mg/kg., p.o. alone did not alter any of the parameters as compared to vehicle-treated Wistar rats. Punica granatum-treated animals showed a lesser degree of cellular infiltration in histopathological studies. Conclusion: Punica granatum ameliorates cardiotoxic effects of isoproterenol and may be of value in the treatment of MI.

  2. Evaluation of roselle (Hibiscus sabdariffa) leaf and pomegranate (Punica granatum) fruit rind for activity against Meloidogyne incognita

    Pomegranate (Punica granatum) fruit and roselle (Hibiscus sabdariffa) leaves have been used in traditional medicine, including as anthelmintics. Methanolic extracts from these plants were investigated for activity against the southern root-knot nematode (RKN) Meloidogyne incognita. Dried, ground p...

  3. In Vitro and In Vivo Antibacterial Activity of Punica granatum Peel Ethanol Extract against Salmonella

    Jung-Rae Rho; Dong-Won Shin; Hun-Soo Kim; Hyun Park; Dong-Hwan Sohn; Min-San Kim; Obiang-Obounou Brice; You-Chang Oh; Hee-Sung Chae; Young-Seob Lee; Ok-Hwa Kang; Jang-Gi Choi; Dong-Yeul Kwon

    2011-01-01

    Punica granatum is commonly used in Korea as a traditional medicine for the treatment of pathogenic bacteria. In this study, we investigated the in vitro and in vivo antimicrobial activity of P. granatum peel EtOH extract (PGPE) against 16 strains of Salmonella. The minimal inhibitory concentrations of PGPE were in the range of 62.5–1000 x03BCg mL-1. In addition, the in vivo antibacterial activity of the PGPE extract was examined in a S. typhimurium infection mouse model. Mice were initially ...

  4. EVALUTION OF ANTI-INFLAMMATORY AND ANALGESIC ACTIVITY OF PUNICA GRANATUM LINN

    Priyanka Bagri; Mohd. Ali; Vidhu Aeri; Shahnaz Sultana; Malay Bhowmik

    2010-01-01

    The aqueous-ethanolic (50%) extracts of fruit rind (PGR), flower (PGF), and leaves (PGL) of Punica granatum were examined for its oral anti-inflammatory and analgesic activities at the doses of 150, 250 and 500 mg/kg body weight. Oral pretreatment with the dried extracts of P. granatum produced statistically significant and dose dependent inhibition of edema induced by carrageenan at all doses when compared to the control groups. The highest activity was shown in the PGR that at 500 mg/kg p.o...

  5. EVALUATION OF ANTI-NOCICEPTIVE AND ANTI-INFLAMMATORY ACTIVITY OF PUNICA GRANATUM SEED EXTRACT

    Gupta Jeetendra Kumar

    2011-12-01

    Full Text Available The plant Punica granatum of family Punicaceae is distributed throughout India and reputed to have numerous applications in traditional medicine system. In order to justify its folkloric use in nociception and inflammation, the study was performed.In this study, the extraction of Punica granatum seed extract was carried out in aqueous media. In order to explore its potency, various experimental models of anti-nociceptive and anti-inflammatory activities were taken. The oral administration of the extract 100mg and 200mg per kg body weight showed significant pharmacological action. Furthermore the anti-ulcer activity was carried out with the help of Indomethacin induced ulceration model using Mesoprostol as standard drug and it showed no ulcerogenic effect in wistar albino rats.Overall, the extract was found to be significant anti-nociceptive and anti-inflammatory activity with no ulcerogenic adverse effect.

  6. Punica granatum: A review on its potential role in treating periodontal disease.

    Prasad, Divyashree; Kunnaiah, Ravi

    2014-07-01

    A wide variety of plants possess enormous treasure of medicinal value. Majority of these medicinal plants have been used to treat various systemic conditions successfully. Over the recent years, use of these medicinal plants has resurfaced to treat oral conditions. Among the oral conditions, periodontal disease remains one of the most common. Alternative and preventive options has become the need of the hour in order to overcome the adverse effects of the antimicrobial agents used in large as an adjunct to mainstream periodontal treatment. Punica granatum (Pomegranate) is one of the oldest edible fruit which has a long history as a medicinal fruit. This review is an attempt to highlight the potential of Punica granatum as a preventive and therapeutic aid to periodontal disease. PMID:25210254

  7. Atividade citotóxica e antiangiogênica de Punica granatum L., Punicaceae Cytotoxic and antiangiogenic activities of Punica granatum L., Punicaceae

    Ligianne P. Oliveira; Renata C. Pinheiro; Marcelo S. Vieira; José Realino de Paula; Maria Teresa F. Bara; Marize C. Valadares

    2010-01-01

    Punica granatum L., Punicaceae, amplamente usada no Brasil, foi avaliada quanto ao seu potencial antitumoral in vitroe in vivo. Investigou-se in vitro a citotoxicidade do extrato etanólico do fruto e folha da P. granatumutilizando células K-562 e células do Tumor Ascítico de Ehrlich (TAE), pelos métodos de redução do MTT e exclusão do azul de tripano. Nos estudos in vivoavaliou-se o aumento da sobrevida de animais portadores do TAE e tratados, por via oral, com diferentes doses dos extratos e...

  8. Efektivitas Ekstrak Kulit Buah Delima (Punica Granatum L.) Terhadap Bakteri Aggregatibacter Actinomycetemcomitans Secara In Vitro

    Fitri, Arisma Dwita

    2015-01-01

    Aggregatibacter actinomycetemcomintans (Aa) is one type of pathogenic bacteria that cause periodontal disease found in plaque. The occurance of resistance of microorganisms to synthetic antibiotics and the resulting side effects of herbal ingredients make a good alternative to overcome these weaknesses. Pomegranate (Punica granatum L.) is known to have a wide range of therapeutic properties that antimicrobial, antioxidant, anticarcinogenic and antiinflammatory activity. The aim of this study ...

  9. Protective effects of pomegranate (Punica granatum) juice on testes against carbon tetrachloride intoxication in rats

    Ebtesam M Al-Olayan; El-Khadragy, Manal F.; Metwally, Dina M; Ahmed E. Abdel Moneim

    2014-01-01

    Background Pomegranate fruit has been extensively used as a natural medicine in many cultures. The present study was aimed at evaluating the protective effects of pomegranate (Punica granatum) juice against carbon tetrachloride (CCl4)-induced oxidative stress and testes injury in adult Wistar rats. Methods Twenty eight Wistar albino male rats were divided equally into 4 groups for the assessment of protective potential of pomegranate juice. Rats of group I (control) received only vehicles and...

  10. Penetapan kadar kalium dan fosfor dalam buah delima merah (Punica granatum L.)

    Pahrianisa, Juli

    2016-01-01

    Pomegranate (Punica granatum L.) is a plant of the punicaceae, which contains a variety of nutrients, especially minerals are potassium and phosphorus, which can prevent bone damage. From the results of the analysis can be a significant difference between the levels of calcium and phosphorus in red pomegranate’s fruit local and import also in seed and seedless pomegranate. Determination of potassium, phosphorus in pomegranate local and pomegranate import by atomic absorption spectrophotome...

  11. Beneficial effect of Punica granatum peel extract on murine malaria-induced spleen injury

    Mubaraki, Murad A.; Hafiz, Taghreed A.; Dkhil, Mohamed A.; Al-Quraishy, Saleh

    2016-01-01

    Background Multiple drug-resistant malaria parasites have been widely detected, which has encouraged research studies focused on discovering alternative therapies. Medicinal plants such as pomegranate, Punica granatum, have been proven to exhibit antiprotozoal effects and therefore, we examined its effects on murine malaria-induced splenic injury and oxidative stress in this study. Methods Mice were divided into three groups, a vehicle control and two groups that were infected with 106 Plasmo...

  12. Bactericidal Effect of Aqueous Extracts of the Bark of the Pomegranate (Punica granatum L.) on Bacteria

    Rabah Chadli; Aman Bouzid; Khadidja Bouzid; Hamida Nader

    2015-01-01

    This research concerns the study of antibacterial properties of different aqueous extracts of the bark of the pomegranate (Punica granatum L.). Three bacterial strains were used in this test: Staphylococcus aureus, Pseudomonas aeruginosa and Salmonella. Very interesting bactericidal properties of aqueous extracts of the bark of the pomegranate were found on bacteria. The inhibition zones have a very large diameter up to 20 mm and the MIC and MBC are low, of the order of 0.78 mg/ml. This work ...

  13. Efektivitas Ekstrak Kulit Buah Delima (Punica granatum L.) terhadap Bakteri Porphyromonas gingivalis secara in vitro

    Shinta

    2014-01-01

    Porphyromonas gingivalis is one of the most commonly bacteria that found in periodontal disease. The use of a synthetic antimicrobial treatment of periodontal disease has many side effects. The potential of natural ingredients from plants for oral prophylaxis should be considered. Pomegranate (Punica granatum L) has been known for hundreds of years for the benefit of human health, including antimicrobial activity. Pomegranate rich in phenolic, flavonoids, tannins, and anthocyanin. The conten...

  14. Development and characterization of SSR markers for pomegranate (Punica granatum L.) using an enriched library

    Hasnaoui, Nejib; Buonamici, Anna; Sebastiani, Federico; Mars, Messaoud; Trifi, Mokhtar; Vendramin, Giovanni

    2010-01-01

    In the present work, we report the development of 11 microstallite markers (SSR) for Punica granatum. Evaluated on a set of 27 pomegranate accessions sampled in Tunisia, they displayed 25 alleles, with number of alleles per locus ranging between 1 and 4, and an observed heterozygosity from 0.037 and 0.592. This set of SSR markers can be very useful for studies dealing with genetic diversity assessment of germplasm, with cultivars/varieties fingerprinting and pedigree analysis of this economic...

  15. A NEW LANOSTANYL DIGLUCURONOSIDE FROM THE FLOWERS OF PUNICA GRANATUM L.

    Ali Mohd; Jabbar Zoobi

    2011-01-01

    One new triterpene glycoside characterized as lanastan–3β–yl–glucuronopyranosyl–(61)–glucuronopyranoside has been isolated from the flowers of Punica granatum L. (Punicaceae) along with oleanolic acid acetate, n-triacontane, n-henetriacontane, tetratriacontane, n-tetracontane, 3- epi-α-amyrin, lanostenyl glucoside, β-sitosterol glycoside, trixyloside and hydroxynaphthoquinone as the known compounds . The structures of all the phytoconstituents have been elucidated on the basis of spectra...

  16. ASSESSMENT OF ANTIMICROBIAL ACTIVITY OF PUNICA GRANATUM AGAINST ANTIBIOTIC-RESISTANT CLOSTRIDIUM PERFRINGENS TYPE (D)

    FRDOOS AL FADEL , SHAZA AL LAHAM, HASSANA CHOUR

    2015-01-01

    The search for new antibiotics and alternative products to solve the increasing number of bacterial resistance to customary antibiotics has become an urgent need. To investigate the effectiveness of the extracts prepared from different parts of Syrian Punica granatum Linn (family Punicaceae), against Clostridium perfringens type (D), which is resistant against many antibiotics, 684 samples were isolated from intestines and livers of death goats by using blood agar, and a selective agar for gr...

  17. Antioxidant activity, cito- and phototoxicity of pomegranate (Punica granatum L.) seed pulp extract

    Carla Aparecida Pedriali; Adjaci Uchoa Fernandes; Patricia Araujo dos Santos; Moisés Melquíades da Silva; Divinomar Severino; Mauricio Baptista da Silva

    2010-01-01

    In the present work, a hydroethanolic extract was prepared from the entire seeds of pomegranate [Punica granatum L. (Punicaceae)] with Cachaça, a distilled Brazilian alcoholic beverage, protected from light for an 80-hour period. The desorption curve of the seeds, presented an optimal time extraction of approximately 24 hours. The extract was divided into two samples: protected from light, (Extract 1), or not, (Extract 2). The extracts were characterized by UV-Visible absorption spectroscopy,...

  18. Protective Effects of Punica Granatum Seeds Extract Against Aging and Scopolamine Induced Cognitive Impairments in Mice

    Kumar, Sokindra; Maheshwari, Kamal Kishore; Singh, Vijender

    2008-01-01

    Dementia is one of the age related mental problems and characteristic symptom of various neurodegenerative diseases including Alzheimer's disease. This impairment probably is due to the vulnerability of the brain cells to increased oxidative stress during aging process. Many studies have shown that certain phenolic antioxidants attenuate neuronal cell death induced by oxidative stress. The present work was undertaken to assess the effect of ethanolic extract of Punica granatum seeds on cognit...

  19. Lipid Lowering Effect of Punica granatum L. Peel in High Lipid Diet Fed Male Rats

    Alireza Sadeghipour; Maryam Eidi; Ali Ilchizadeh Kavgani; Reza Ghahramani; Saleh Shahabzadeh; Ali Anissian

    2014-01-01

    Many herbal medicines have been recommended for the treatment of dyslipidemia. The antilipidemic effect of hydroethanolic extract of pomegranate peel (Punica granatum L.) was investigated in high lipid diet fed male rats. Intraperitoneally administration of pomegranate peel extract (50, 100, 200, and 300 mg/kg body weight) for 23 days on the levels of serum cholesterol, triglycerides, LDL, HDL, alkaline phosphatase (AP), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) in ...

  20. Lipid composition of seed oils of different pomegranate (Punica granatum L.) cultivars from Spain

    Luana Fernandes; Pereira, José A.; Isabel Lopéz-Cortés; Salazar, Domingo M.; Elsa Ramalhosa; Susana Casal

    2015-01-01

    Pomegranate (Punica granatum L.) is an ancient fruit tree traditionally cultivated in the Near and Middle East. Presently, its most important growing regions include Afghanistan, Iran, Israel, USA, Italy and Spain, the latter country the largest European exporter. The pomegranate fruit can be divided into several anatomical compartments: outside peel, inside peel, and arils (pulp and seeds), the last part being usually used for consumption as is or for juice, jams and jellies production. Even...

  1. ASSESSMENT OF ANTIMICROBIAL ACTIVITY OF PUNICA GRANATUM AGAINST ANTIBIOTIC-RESISTANT CLOSTRIDIUM PERFRINGENS TYPE (D

    FRDOOS AL FADEL , SHAZA AL LAHAM, HASSANA CHOUR

    2015-06-01

    Full Text Available The search for new antibiotics and alternative products to solve the increasing number of bacterial resistance to customary antibiotics has become an urgent need. To investigate the effectiveness of the extracts prepared from different parts of Syrian Punica granatum Linn (family Punicaceae, against Clostridium perfringens type (D, which is resistant against many antibiotics, 684 samples were isolated from intestines and livers of death goats by using blood agar, and a selective agar for growing of Clostridium perfringens(SPS agar. The isolated bacteria were typed by using ELISA apparatus. Many parts of Punica granatum was extracted with water, absolute alcohol, then ether by using soxhlet apparatus and rotary evaporator. The Antibiotic susceptibility testing of many antibiotics was conducted by using disc diffusion method in anaerobic atmosphere and break points method. The alcoholic extracts prepared from many parts of punica granatum (pericarp, leaves, flowers, seeds showed different antibacterial effect against Clostridium perfringens type(D,whereas the studied antibiotics had not shown any antibacterial effect, except Clindamycin which showed partial effectiveness. 

  2. Studies on the Cytotoxic Activities of Punica granatum L. var. spinosa (Apple Punice) Extract on Prostate Cell Line by Induction of Apoptosis

    Koushan Sineh Sepehr; Behzad Baradaran; Masoumeh Mazandarani; Vahid Khori; Fatemeh Zare Shahneh

    2012-01-01

    The Punica granatum L. var. granatum (pomegranate) has been demonstrated to exert antitumor effects on various types of cancer cells. The present study aimed to evaluate the medicinal herbs Punica granatum L. var. spinosa (apple punice) that are native to Iran. This study was determined to test the possible cytotoxic activity and induction of apoptosis on human prostate cell lines. The effect of ethanol extracts of the herbs on the inhibition of cell proliferation was assessed by MTT colorime...

  3. Atividade citotóxica e antiangiogênica de Punica granatum L., Punicaceae Cytotoxic and antiangiogenic activities of Punica granatum L., Punicaceae

    Ligianne P. Oliveira

    2010-05-01

    Full Text Available Punica granatum L., Punicaceae, amplamente usada no Brasil, foi avaliada quanto ao seu potencial antitumoral in vitroe in vivo. Investigou-se in vitro a citotoxicidade do extrato etanólico do fruto e folha da P. granatumutilizando células K-562 e células do Tumor Ascítico de Ehrlich (TAE, pelos métodos de redução do MTT e exclusão do azul de tripano. Nos estudos in vivoavaliou-se o aumento da sobrevida de animais portadores do TAE e tratados, por via oral, com diferentes doses dos extratos etanólicos da P. granatum(12,5; 25; 50 e 100 mg/kg por dez dias consecutivos. Além disso, nestes animais analisou-se o potencial de inibição tumoral e a atividade antiangiogênica da P. granatum. Os resultados dos estudos in vitrodemonstraram uma redução na viabilidade das células K-562 e do TAE, concentração-dependente, nos métodos investigados. Os resultados in vivo demonstraram aumento da sobrevida dos animais portadores do TAE tratados, de forma dose-dependente. Em paralelo, observou-se diminuição do número de células tumorais na cavidade peritoneal dos animais portadores e tratados. Além disto, os tratamentos empregados reduziram o padrão de vascularização da parede abdominal. Dessa forma, os dados apresentados revelaram que o extrato de P. granatumpossui atividade antitumoral in vitroe in vivo em paralelo a redução da angiogênese peritoneal.Punica granatum L., a plant widely used in Brazil, was tested for its antitumor and antiangiogenic activities in vitroand in vivo. In this work, the in vitrocytotoxicity was evaluated using the K-562 cell line and Ehrlich ascites tumour cells, by MTT tetrazolium reduction test and the trypan blue exclusion test. In vivostudies investigated the increase in the survival time of Ehrlich tumour-bearing mice after treatment with different doses of Punica granatumL. ethanol extract (12.5; 25; 50 e and 100 mg/kg, by gavages, for ten consecutive days. In addition, we also investigated the tumour

  4. Pharmacological investigations of Punica granatum in glycerol-induced acute renal failure in rats

    Amrit Pal Singh

    2011-01-01

    Full Text Available Objective : The present study was designed to investigate the ameliorative potential and possible mechanism of hydroalcoholic extract of flowers of P. granatum in glycerol-induced acute renal failure (ARF in rats. Materials and Methods : The rats were subjected to rhabdomyolytic ARF by single intramuscular injection of hypertonic glycerol (50% v/v; 8 ml/kg and the animals were sacrificed after 24 hours of glycerol injection. The plasma creatinine, blood urea nitrogen, creatinine clearance, and histopathological studies were performed to assess the degree of renal injury. Results : Pretreatment with hydroalcoholic extract of flowers of P. granatum (125 and 250 mg/kg p.o. twice daily for 3 days significantly attenuated hypertonic glycerol-induced renal dysfunction in a dose-dependent manner. BADGE (Bisphenol-A-diglycidyl ether (30 mg/kg, a peroxisome proliferator-activated receptor (PPAR-γ antagonist, and N(omega-nitro-l-arginine-methyl ester (L-NAME (10, 20, and 40 mg/kg, nitric oxide synthase inhibitor, were employed to explore the mechanism of renoprotective effects of Punica granatum. Administration of BADGE (30 mg/kg and L-NAME (40 mg/kg abolished the beneficial effects of P. granatum in glycerol-induced renal dysfunction. Conclusion : Hydroalcoholic extract of flowers of P. granatum has ameliorative potential in attenuating myoglobinuric renal failure and its renoprotective effects involve activation of PPAR-γ and nitric oxide-dependent signaling pathway.

  5. Antibacterial Effect of Hydroalcoholic Extract of Punica granatum Linn. Petal on Common Oral Microorganisms.

    Hajifattahi, Farnaz; Moravej-Salehi, Elham; Taheri, Maryam; Mahboubi, Arash; Kamalinejad, Mohammad

    2016-01-01

    Objectives. This study aimed to assess the effect of hydroalcoholic extract of Punica granatum Linn. (P. granatum) petal on Streptococcus sanguinis, Streptococcus mutans, Streptococcus salivarius, Streptococcus sobrinus, and Enterococcus faecalis. Materials and Methods. In this in vitro study, P. granatum extract was prepared using powdered petals and water-ethanol solvent. Antibacterial effect of the extract, chlorhexidine (CHX), and ampicillin was evaluated on brain heart infusion agar (BHIA) using the cup-plate method. By assessing the diameter of the growth inhibition zone, the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of the extract were determined for the above-mentioned bacteria. Results. Hydroalcoholic extract of P. granatum petal had inhibitory effects on the proliferation of all five bacterial strains with maximum effect on S. mutans with MIC and MBC of 3.9 mg/mL. The largest growth inhibition zone diameter belonged to S. sanguinis and the smallest to E. faecalis. Ampicillin and CHX had the greatest inhibitory effect on S. sanguinis. Conclusions. Hydroalcoholic extract of P. granatum had a significant antibacterial effect on common oral bacterial pathogens with maximum effect on S. mutans, which is the main microorganism responsible for dental plaque and caries. PMID:26884763

  6. Antibacterial Effect of Hydroalcoholic Extract of Punica granatum Linn. Petal on Common Oral Microorganisms

    Farnaz Hajifattahi

    2016-01-01

    Full Text Available Objectives. This study aimed to assess the effect of hydroalcoholic extract of Punica granatum Linn. (P. granatum petal on Streptococcus sanguinis, Streptococcus mutans, Streptococcus salivarius, Streptococcus sobrinus, and Enterococcus faecalis. Materials and Methods. In this in vitro study, P. granatum extract was prepared using powdered petals and water-ethanol solvent. Antibacterial effect of the extract, chlorhexidine (CHX, and ampicillin was evaluated on brain heart infusion agar (BHIA using the cup-plate method. By assessing the diameter of the growth inhibition zone, the minimum inhibitory concentration (MIC and minimum bactericidal concentration (MBC of the extract were determined for the above-mentioned bacteria. Results. Hydroalcoholic extract of P. granatum petal had inhibitory effects on the proliferation of all five bacterial strains with maximum effect on S. mutans with MIC and MBC of 3.9 mg/mL. The largest growth inhibition zone diameter belonged to S. sanguinis and the smallest to E. faecalis. Ampicillin and CHX had the greatest inhibitory effect on S. sanguinis. Conclusions. Hydroalcoholic extract of P. granatum had a significant antibacterial effect on common oral bacterial pathogens with maximum effect on S. mutans, which is the main microorganism responsible for dental plaque and caries.

  7. Antihyperglycemic, antioxidant and hypolipidemic effect of Punica granatum L flower extract in streptozotocin induced diabetic rats

    Anusha Bhaskar; Anish Kumar

    2012-01-01

    Objective: To investigate the antihyperglycemic, hypolipidemic and antioxidant effects of aqueous and ethanolic flower extracts of Punica granatum (P. granatum) in streptozotocin (STZ) induced diabetes mellitus in wistar rats. Methods: Antihyperglycemic, hypolipidemic and antioxidant effect of P. granatum aqueous (PGFAet) and ethanolic extracts (PGFEet) at doses of 200 and 400 mg/kg bw was evaluated in streptozotocin induced diabetic rats. Glycosylated hemoglobin, plasma insulin, cholesterol and lipoprotein levels, lipid peroxide levels and the antioxidant enzyme levels were determined. Results: The administration of the extracts markedly reduced blood glucose and glycosylated hemoglobin increased the levels of plasma insulin and liver glycogen. The extract also had a hypolipidemic activity decreasing the levels of total cholesterol, LDL-cholesterol, VLDL-cholesterol and triglycerides. The levels of lipid peroxides in terms of thiobarbituric acid reactive substances (TBARS) were remarkably reduced and the activities of the enzymes SOD, CAT and GPx and GSH were increased. We also saw an increase in the activity of the enzyme glucokinase and decrease in glucose-6-phosphatase. It can be concluded that the flower extracts of P. granatum (PGFAet and PGFEet) has significant restorative effect on the blood glucose, hyperlipidemia and oxidative stress. Conclusions: It can be concluded from the studies that the ethanolic extracts of the flowers of P. granatum at dosage 400 mg/kg/day exhibit significant effect in lowering blood sugar and lipid levels and increasing the antioxidant enzymes when compared to the aqueous extract. Glycosylated hemoglobin levels were reduced and the extract exhibited a stimulatory effect on insulin.

  8. Effect ofPunica granatum peel extract on learning and memory in rats

    Shalini Adiga; Prabhav Trivedi; Ravichandra V; Debashree Deb; Forum Mehta

    2010-01-01

    Objective:To evaluate potential memory enhancing effect ofPunica granatum peel extract on rats.Methods: Healthy adult male albino rats of Wistar strain were used. Each group of6 rats were administered either distilled water or50mg/kg of extract or100 mg/kg of extract for 15days and subjected to passive avoidance test or T-maze test. In the next phase rats were administered distilled water or100 mg/kg of extract for15 days and the rats were given injection diazepam before subjecting them to the tests.Results:The overall performance was better in test groups compared to control groups. Among the test groups,100 mg/kg rats performed better than50mg/kg. The effect on spatial learning parameters like mean number of alternations and mean percentage bias was more marked compared to retention testing parameters like latency. 100 mg/kg Punica extract treated group also improved performance of diazepam treated rats. Conclusions:There is a definite trend of memory improvement byPunica granatum peel with effects being more marked on spatial learning tendency and long term memory than on retention capacity.

  9. Effect of Punica granatum L. Flower Water Extract on Five Common Oral Bacteria and Bacterial Biofilm Formation on Orthodontic Wire

    Elahe Vahid Dastjerdi; Zahra Abdolazimi; Marzieh Ghazanfarian; Parisa Amdjadi; Mohammad Kamalinejad; Arash Mahboubi

    2014-01-01

    Background: Use of herbal extracts and essences as natural antibacterial compounds has become increasingly popular for the control of oral infectious diseases. Therefore, finding natural antimicrobial products with the lowest side effects seems necessary. The present study sought to assess the effect of Punica granatum L. water extract on five oral bacteria and bacterial biofilm formation on orthodontic wire. Methods: Antibacterial property of P. granatum L. water extract was primarily evalua...

  10. A Review on Antihyperglycemic and Antihepatoprotective Activity of Eco-Friendly Punica granatum Peel Waste

    Sushil Kumar Middha

    2013-01-01

    Full Text Available Over the past decade, pomegranate (Punica granatum is entitled as a wonder fruit because of its voluminous pharmacological properties. In 1830, P. granatum fruit was first recognized in United States Pharmacopeia; the Philadelphia edition introduced the rind of the fruit, the New York edition the bark of the root and further 1890 edition the stem bark was introduced. There are significant efforts and progress made in establishing the pharmacological mechanisms of peel (pericarp or rind and the individual constituents responsible for them. This review provides an insight on the phytochemical components that contribute too antihyperglycemic, hepatoprotective, antihyperlipidemic effect, and numerous other effects of wonderful, economic, and eco-friendly pomegranate peel extract (PP.

  11. Chromatographic analysis and antiproliferative potential of aqueous extracts of Punica granatum fruit peels using the Allium cepa test

    Andrielle Wouters Kuhn; Marília Tedesco; Aline Augusti Boligon; Margareth Linde Athayde; Haywood Dail Laughinghouse IV; Solange Bosio Tedesco

    2015-01-01

    Punica granatum L., locally known as romanzeira, is native to Asia but found throughout Brazil. P. granatum is used for treating inflammatory, infectious and respiratory diseases. The aim of this study was to evaluate the chromatography and genotoxicity of an aqueous extract of P. granatum (pomegranate) fruit peel using the Allium cepa L. test. The experiment set-up entailed 7 treatments: T1-distilled water, T2-tea 5 g.L-1, T3-tea 10 g.L-1, T4-glyphosate at 9.6%, T5-glyphosate with subsequent...

  12. Punica granatum and its therapeutic implications on breast carcinogenesis: A review.

    Vini, Ravindran; Sreeja, Sreeharshan

    2015-01-01

    Punica granatum has a recorded history of pharmacological properties which can be attributed to its rich reservoir of phytochemicals. Investigations in recent years have established its tremendous potential as an antitumorogenic agent against various cancers including breast cancer, which is the second leading cause of cancer-related deaths in women. The plausible role of Punica as a therapeutic agent, as an adjuvant in chemotherapy, and its dietary implications as chemopreventive agent in breast cancer have been explored. Mechanistic studies have revealed that Punica extracts and its components, individually or in combination, can modulate and target key proteins and genes involved in breast cancer. Our earlier finding also demonstrated the role of methanolic extract of pomegranate pericarp in reducing proliferation in breast cancer by binding to estrogen receptor at the same time not affecting uterine weight unlike estradiol or tamoxifen. This review analyses other plausible mechanisms of Punica in preventing the progression of breast cancer and how it can possibly be a therapeutic agent by acting at various steps of carcinogenesis including proliferation, invasion, migration, metastasis, angiogenesis, and inflammation via various molecular mechanisms. PMID:25857627

  13. Utilization of the pomegranate tree (Punica granatum L.) in the paper industry

    GÜLSOY, SEZGİN KORAY; PEKGÖZLÜ, AYBEN KILIÇ; AKTAŞ, ASLI CEREN

    2015-01-01

    In this study, the chemical composition, fiber morphology, pulp, and paper properties of the pomegranate tree (Punica granatum L.) were determined. Stem and branch wood were analyzed separately. Kraft and kraft- anthraquinone (AQ) methods were used for the pulping processes. Stem wood showed superiority to branch wood with longer, wider, thicker-walled fibers. The holocellulose, $\\alpha$-cellulose, and lignin contents of branch and stem wood were 72.98%-73.50%, 38.37%-39.92%, and 21.04%-25.29...

  14. Antibacterial activity of crude extract of Punica granatum pericarp on pathogenic Gram-negative bacilli.

    Voravuthikunchai, S.; Supavita, T.; Sirirak, T.; Panthong, K.

    2005-01-01

    The objective of this study was to investigate the effect of crude extracts of Punica granatum Linn. pericarp with 3 different solvents against pathogenic Gram-negative bacilli. Ethanolic extracts showed the antibacterial activity against all strains tested including enterohaemorrhagic Escherichia coli 4 strains (E. coli O157: H7, E. coli O26: H11, E. coli O111: NM, E. coli O22), Pseudomonas aeruginosa, Shigella boydii and Salmonella london. Inhibition zones ranged from 10.02 to 19.15 mm. Min...

  15. AMELIORATIVE EFFECT OF PUNICA GRANATUM ETHANOLIC EXTRACT IN CYCLOPHOSPHAMIDE INDUCED TESTICULAR TOXICITY IN MALE WISTAR RATS

    Divya Bhargavan; Harish Shetty; AP Krishna

    2015-01-01

    Aim: To explore the potential role of Punica granatum ethanolic extract (PGEE) in Cyclophosphamide (CP) induced testicular toxicity. Methods: Healthy male Wistar rats were allotted to 4 groups (N=6, each) Group I: Control, Group II: CP 15mg/kg twice a week, Group III: PGEE 100mg/kg, Group IV: CP and PGEE for 28 days. At the end of the treatment period, organ weight, body weight, epididymal sperm count, motility, morphology, SOD, catalase, GSH, ACP & testosterone level in the testis were evalu...

  16. A NEW LANOSTANYL DIGLUCURONOSIDE FROM THE FLOWERS OF PUNICA GRANATUM L.

    Ali Mohd

    2011-07-01

    Full Text Available One new triterpene glycoside characterized as lanastan–3β–yl–glucuronopyranosyl–(61–glucuronopyranoside has been isolated from the flowers of Punica granatum L. (Punicaceae along with oleanolic acid acetate, n-triacontane, n-henetriacontane, tetratriacontane, n-tetracontane, 3- epi-α-amyrin, lanostenyl glucoside, β-sitosterol glycoside, trixyloside and hydroxynaphthoquinone as the known compounds . The structures of all the phytoconstituents have been elucidated on the basis of spectral data analysis and chemical reactions.

  17. Punica granatum leave extract as green corrosion inhibitor for mild steel in Hydrochloric acid

    Abboud Y.; Chagraoui A.; Tanane O.; El Bouari A.; Hannache H.

    2013-01-01

    Leave of Punica granatum extract (LPGE) as green inhibitor for the corrosion of mild steel in 1M HCl solution was studied using weight-loss and potentiodynamic polarization measurements. The results obtained revealed that LPGE has fairly good inhibiting properties for mild steel corrosion in 1M HCl solution, with efficiency of around 94 % at a concentration of 1 g/l. The inhibition was of a mixed anodic–cathodic nature. The film which is formed over the metal surface was analysed by FT-IR spe...

  18. EVALUATION OF ANTI-INFLAMMATORY AND ANALGESIC ACTIVITY OF PUNICA GRANATUM LINN LEAVES

    Nain Parminder; Saini Mamta; Malik Manisha

    2011-01-01

    The methanolic extract of dried leaves of Punica granatum linn was studied for the anti-inflammatory activity in rat using carrageenan induced paw edema with plethysmometer and analgesic activity on mice by Eddy’s hot plate & tail immersion method. A preliminary phytochemical screening of leaves extract revealed the presence of alkaloids, tannins, flavonoids, and steroids. Among all the doses (200mg/kg, 400mg/kg, 600mg/kg, 800mg/kg) of methanolic extract 600mg/kg orally showed maximum signifi...

  19. Anticoagulant, antiplatelet and antianemic effects of Punica granatum (pomegranate) juice in rabbits.

    Riaz, Azra; Khan, Rafeeq A

    2016-04-01

    Pomegranate (Punica granatum L., Punicaceae) is a good source of minerals and phytochemicals with diverse pharmacological activities such as anxiolytic, antidepressant, hypoglycemic, hypolipidemic, and anti-inflammatory activities. Effects of P. granatum on blood parameters and coagulation have, however, been little studied. The aim of the study was to assess the outcome of P. granatum on coagulation and anticoagulation factors at different doses on blood samples of healthy white rabbits. Blood samples of the animals were collected twice during the study and biochemical assays were performed to assess the effect on hematological, coagulation, anticoagulation, and platelet aggregation. Significant changes were observed in erythrocytes, hemoglobin, and mean corpuscular hemoglobin concentration, while bleeding and thrombin time were also prolonged significantly. There was significant increase in protein C, thrombin antithrombin complex levels, and decrease in platelet aggregation and fibrinogen concentration, in a dose-dependent manner. The results of hematological and coagulation assays lead to the speculation about a possible antianemic and cardioprotective effect of P. granatum. PMID:26881853

  20. Apoptotic effects of non-edible parts of Punica granatum on human multiple myeloma cells.

    Kiraz, Yağmur; Neergheen-Bhujun, Vidushi S; Rummun, Nawraj; Baran, Yusuf

    2016-02-01

    Multiple myeloma is of great concern since existing therapies are unable to cure this clinical condition. Alternative therapeutic approaches are mandatory, and the use of plant extracts is considered interesting. Punica granatum and its derived products were suggested as potential anticancer agents due to the presence of bioactive compounds. Thus, polypenolic-rich extracts of the non-edible parts of P. granatum were investigated for their antiproliferative and apoptotic effects on U266 multiple myeloma cells. We demonstrated that there were dose-dependent decreases in the proliferation of U266 cells in response to P. granatum extracts. Also, exposure to the extracts triggered apoptosis with significant increases in loss of mitochondrial membrane potential in U266 cells exposed to the leaves and stem extracts, while the flower extract resulted in slight increases in loss of MMP. These results were confirmed by Annexin-V analysis. These results documented the cytotoxic and apoptotic effects of P. granatum extracts on human U266 multiple myeloma cells via disruption of mitochondrial membrane potential and increasing cell cycle arrest. The data suggest that the extracts can be envisaged in cancer chemoprevention and call for further exploration into the potential application of these plant parts. PMID:26318303

  1. Antibacterial and Antifungal Activities of Punica Granatum Peel Extracts Against Oral Pathogens

    Sh. Abdollahzadeh

    2011-03-01

    Full Text Available Objective: Punica granatum has been used for many years in folk medicine due to several purposes. The aim of the present study was to evaluate the effect of methanolic extract of Punica granatum peel (MEPGP against Streptococcus mutans, Staphylococcus aureus,Streptococcus salivarius, Streptococcus sanguinis, Staphylococcus epidermidis, Actynomyces viscosus, Lactobacillus acidophilus and Candida albicans.Materials and Methods: In this in vitro study, the mentioned oral organisms were cultured in blood agar and mueller-hinton media and then paper disks containing MEPGP at concentrations of 4 mg/ml, 8 mg/ml and 12 mg/ml were inserted on medias. The antimicrobialactivity was evaluated by agar disk diffusion method. The effects of three different concentrations of MEPGP against microorganisms were compared using one-way ANOVA and Tukey tests.Results: All concentrations of MEPGP had antibacterial activity against S. aureus and S.epidermidis. Only at concentration of 8 mg/ml and 12 mg/ml MEPGP was effective against L. acidophilus, S. mutans and S. salivarius. Furthermore; no concentrations ofMEPGP inhibited A. viscosus and C. albicans.Conclusion: This study suggests that MEPGP might be used as an antibacterial agent in controlling oral infections.

  2. Isolation and Standardization of Various Phytochemical Constituents from Methanolic Extracts of Fruit Rinds of Punica granatum

    Vishal Jain; Murugananthan G; Deepak M; GL Viswanatha; D Manohar

    2011-01-01

    AIM:The present study was undertaken to isolate and standardize the various active phytochemical constituents present in the fruit rinds of Punica granatum.METHODS:Fruit rinds of Punica granatum were dried and extracted with methanol in a static extractor; the percentage yield of the methanolic extract (MEPG) was found to be 26%; the methanolic extract was partitioned using n-butanol,ethyl acetate and water; the percentage yield of the fractions were found to be 17.16%,26.88% and 47.72% respectively.HPLC was carried out for all the fractions and the markers corresponding to the major peaks in HPLC were isolated using column chromatography.The isolated markers were characterized using UV,IR,Mass and NMR spectroscopy.RESULTS & CONCLUSION:Totally four compounds were isolated and identified as punicalin,punicalagin,gallic acid and ellagic acid based on UV,IR,Mass and NMR data,they were standardized by HPLC.

  3. EVALUTION OF ANTI-INFLAMMATORY AND ANALGESIC ACTIVITY OF PUNICA GRANATUM LINN

    Priyanka Bagri

    2010-12-01

    Full Text Available The aqueous-ethanolic (50% extracts of fruit rind (PGR, flower (PGF, and leaves (PGL of Punica granatum were examined for its oral anti-inflammatory and analgesic activities at the doses of 150, 250 and 500 mg/kg body weight. Oral pretreatment with the dried extracts of P. granatum produced statistically significant and dose dependent inhibition of edema induced by carrageenan at all doses when compared to the control groups. The highest activity was shown in the PGR that at 500 mg/kg p.o. inhibited inflammation by 82.14%. (79 % for indomethacin at 10 mg/kg. On the contrary, the aqueous-ethanolic (50 % extracts of PGF and PGL exhibited 71.42% and 67.85% inhibition, respectively, at 500 mg/kg dose. The extracts at tested doses were found to possess analgesic activity in mice against tail-flick method. These results indicated that extracts of P. granatum possessed significant anti-inflammatory and analgesic activities suggesting its potential as an anti-inflammatory agent for use in the treatment of various inflammatory diseases in traditional medicine.

  4. Antibacterial activity of crude extract of Punica granatum pericarp on pathogenic Gram-negative bacilli.

    Voravuthikunchai, S.

    2005-08-01

    Full Text Available The objective of this study was to investigate the effect of crude extracts of Punica granatum Linn. pericarp with 3 different solvents against pathogenic Gram-negative bacilli. Ethanolic extracts showed the antibacterial activity against all strains tested including enterohaemorrhagic Escherichia coli 4 strains (E. coli O157: H7, E. coli O26: H11, E. coli O111: NM, E. coli O22, Pseudomonas aeruginosa, Shigella boydii and Salmonella london. Inhibition zones ranged from 10.02 to 19.15 mm. Minimum inhibitory concentration (MIC and minimum bactericidal concentration (MBC ranged from 0.09 to 3.13 mg/ml and 3.13 to 25 mg/ml, respectively. Aqueous extract had low antibacterial activity while crude chloroform extracts had no effect on the growth of these strains. Ethyl acetate and n-butanol fractions of P. granatum pericarp demonstrated high activity with the best MIC and MBC values of 0.02 to 0.78 mg/ml and 0.19 to 6.25 mg/ml, respectively. As ethanolic extract of P. granatum was very effective against these pathogenic bacteria, further investigation on this plant species may provide alternative, but bioactive, medicines for the treatment of Gram-negative bacterial infection.

  5. Preparation and characterisation of Punica granatum pericarp aqueous extract loaded chitosan-collagen-starch membrane: role in wound healing process.

    Amal, B; Veena, B; Jayachandran, V P; Shilpa, Joy

    2015-05-01

    Engineered scaffolds made from natural biomaterials are crucial elements in tissue engineering strategies. In this study, biological scaffold like chitosan-collagen-starch membrane (CCSM) loaded with the antibacterial agent, Punica granatum pericarp aqueous extract was explored for enhanced regeneration of epithelial tissue during wound healing. Collagen was extracted from Rachycentron canadum fish skin. Membranous scaffold was prepared by mixing collagen, starch and chitosan in a fixed proportion, loaded with aqueous extract of P. granatum and its anti-pseudomonal activity was studied. Morphological characterization by SEM and mechanical property like tensile strength of the membrane were studied. Excision wound of 2 cm(2) size was induced in Guinea pig and the effect of P. granatum extract loaded CCSM in wound healing was studied. The SEM image showed deep pores in the membrane and also possessed good tensile strength. Wound surface area was reduced prominently in the experimental group with P. granatum extract loaded CCSM when compared to the group with unloaded membrane and the one with no membrane. Punica granatum extract loaded CCSM has antipseudomonal property and supported enhanced epithelial cell proliferation without leaving a scar after wound healing. This has significant therapeutic application in membranous scaffold mediated skin repair and regeneration. PMID:25893391

  6. Synthesis of gold nanoparticles using renewable Punica granatum juice and study of its catalytic activity

    Dash, Shib Shankar; Bag, Braja Gopal

    2014-01-01

    Punica granatum juice, a delicious multivitamin drink of great medicinal significance, is rich in different types of phytochemicals, such as terpenoids, alkaloids, sterols, polyphenols, sugars, fatty acids, aromatic compounds, amino acids, tocopherols, etc. We have demonstrated the use of the juice for the synthesis of gold nanoparticles (AuNPs) at room temperature under very mild conditions. The synthesis of the AuNPs was complete in few minutes and no extra stabilizing or capping agents were necessary. The size of the nanoparticles could be controlled by varying the concentration of the fruit extract. The AuNPs were characterized by surface plasmon resonance spectroscopy, high resolution transmission electron microscopy, fourier transform infrared spectroscopy and X-ray diffraction studies. Catalytic activity of the synthesized colloidal AuNPs has also been demonstrated.

  7. AMELIORATIVE EFFECT OF PUNICA GRANATUM ETHANOLIC EXTRACT IN CYCLOPHOSPHAMIDE INDUCED TESTICULAR TOXICITY IN MALE WISTAR RATS

    Divya Bhargavan

    2015-07-01

    Full Text Available Aim: To explore the potential role of Punica granatum ethanolic extract (PGEE in Cyclophosphamide (CP induced testicular toxicity. Methods: Healthy male Wistar rats were allotted to 4 groups (N=6, each Group I: Control, Group II: CP 15mg/kg twice a week, Group III: PGEE 100mg/kg, Group IV: CP and PGEE for 28 days. At the end of the treatment period, organ weight, body weight, epididymal sperm count, motility, morphology, SOD, catalase, GSH, ACP & testosterone level in the testis were evaluated. Results: The CP treated rats showed toxicity evidenced by decreased organ and body weight, decreased sperm quality and testosterone level also increase in MDA and decrease in antioxidants SOD, GSH indicating oxidative stress. In contrast PGEE co-treatment with CP resulted in significant restoration of the above mentioned parameters. Conclusion: These results indicate that PGEE attenuates CP induced testicular toxicity through its ROS scavenging activity.

  8. Punica granatum leave extract as green corrosion inhibitor for mild steel in Hydrochloric acid

    Abboud Y.

    2013-09-01

    Full Text Available Leave of Punica granatum extract (LPGE as green inhibitor for the corrosion of mild steel in 1M HCl solution was studied using weight-loss and potentiodynamic polarization measurements. The results obtained revealed that LPGE has fairly good inhibiting properties for mild steel corrosion in 1M HCl solution, with efficiency of around 94 % at a concentration of 1 g/l. The inhibition was of a mixed anodic–cathodic nature. The film which is formed over the metal surface was analysed by FT-IR spectroscopy. Further examination using X-ray diffraction confirms the role of LPGE as an effective corrosion inhibitor for mild steel in acid media.

  9. Studies on the Cytotoxic Activities of Punica granatum L. var. spinosa (Apple Punice) Extract on Prostate Cell Line by Induction of Apoptosis.

    Sineh Sepehr, Koushan; Baradaran, Behzad; Mazandarani, Masoumeh; Khori, Vahid; Shahneh, Fatemeh Zare

    2012-01-01

    The Punica granatum L. var. granatum (pomegranate) has been demonstrated to exert antitumor effects on various types of cancer cells. The present study aimed to evaluate the medicinal herbs Punica granatum L. var. spinosa (apple punice) that are native to Iran. This study was determined to test the possible cytotoxic activity and induction of apoptosis on human prostate cell lines. The effect of ethanol extracts of the herbs on the inhibition of cell proliferation was assessed by MTT colorimetric assay. PC3 cell lines treated with the extracts were analyzed for the induction of apoptosis by cell death detection (ELISA) and TUNEL assay. Dye exclusion analysis was performed for viability rate. Our results demonstrated that the Punica granatum L. var. spinosa extract dose dependently suppressed the proliferation of PC3 cells (IC(50)= 250.21 μg/mL) when compared with a chemotherapeutic anticancer drug (Toxol) (Vesper Pharmaceuticals) with increased nucleosome production from apoptotic cells. The Punica granatum L. var. spinosa extract attenuated the human prostate cell proliferation in vitro possibly by inducing apoptosis. The Punica granatum L. var. spinosa is likely to be valuable for the treatment of some forms of human prostate cell line. PMID:23320197

  10. Antibiotic activity of the extract of Punica granatum Linn. over bovine strains of Staphylococcus aureus Atividade antimicrobiana do extrato de Punica granatum Linn. em linhagens de Staphylococcus aureus de origem bovina

    Maria A. R. Silva; Jane S. Higino; Jozinete V. Pereira; José P. Siqueira-Júnior; Maria S.V. Pereira

    2008-01-01

    Human and veterinary medicines have not been so well succeeded in order to achieving their goals concerning the treatment of infections for long term caused by Staphylococcus aureus linked to resistance development against antibiotic agents. The antibiotic activity of the Punica granatum Linn. fresh fruit pericarp extract was evaluated by the agar diffusion method on 38 S. aureus strains, isolated from apparently healthy lactating cows in farms situated in counties of the semi-arid region of ...

  11. Antimicrobial Activity of Six Pomegranate (Punica granatum L. Varieties and Their Relation to Some of Their Pomological and Phytonutrient Characteristics

    Nurcan Erbil

    2009-05-01

    Full Text Available Arils from six pomegranate (Punica granatum L. varieties grown in the Mediterranean region of Turkey were tested for their antimicrobial properties by the agar diffusion and minimum inhibitory concentration (MIC methods against seven bacteria: (Bacillus megaterium DSM 32, Pseudomonas aeruginosa DSM 9027, Staphylococcus aureus Cowan 1, Corynebacterium xerosis UC 9165, Escherichia coli DM, Enterococcus faecalis A10, Micrococcus luteus LA 2971, and threefungi (Kluvyeromyces marxianus A230, Rhodotorula rubra MC12, Candida albicans ATCC 1023. It has been observed that the pomegranate aril extracts had antimicrobial effect on all microorganisms, giving inhibition zones ranging in size from 13 to 26 mm. The MIC values for active pomegranate extracts ranged between 30 and >90 µg/mL. The results obtained appeared to confirm the antimicrobial potential of the Punica granatum varieties.

  12. Antibacterial activity of crude ethanolic and fractionated extracts of Punica granatum Linn. fruit peels

    Éverton Silva Santos

    2015-10-01

    Full Text Available Currently it is clear the need to develop new antimicrobial seeking to solve problems such as antibiotic resistance, in this context medicinal plants has been using a prominent place, and knowledge of popular medicine shows itself to be a promising search tool. Peel of Punica granatum fruits are popularly used for the treatment of diarrhea, eye and upper airway inflammation, and in the external treatment of infectious sores. Thus, this study had the objective to evaluate the in vitro inhibitory effect of the crude ethanol extract of peels of P. granatum, three organic fractions and also fractions obtained by column chromatography, on reference microorganisms (Staphylococcus aureus, Escherichia coli, Salmonella typhimurium and Pseudomonas aeruginosa by disk diffusion method. The obtained results evidenced that the ethyl acetate and aqueous fractions facing S. aureus and E. coli showed significant antimicrobial activity, close to the antimicrobial gentamicin and penicillin, respectively. In its turn the crude ethanolic extract of P. granatum and aqueous fraction showed inhibitory effect similar to the antimicrobial tetracycline facing P. aeruginosa. It was observed an increase in the inhibition of the microorganisms with increasing extract volume (from 10 to 30 μL, being S. aureus and P. aeruginosa the most susceptible microorganisms. Differences in activity between the extracts and fractions can be partly explained by qualitative and quantitative variations in the secondary metabolites present in the extracts and fractions.Keywords: Pomegranade. Medicinal plants. Antimicrobial action. RESUMO Atualmente está clara a necessidade do desenvolvimento de novos antimicrobianos buscando resolver problemas como a resistência a antibióticos, neste contexto, as plantas medicinais vem utilizando um lugar de destaque, e os conhecimentos da medicina popular mostram-se uma ferramenta de busca promissora. Cascas dos frutos de Punica granatum s

  13. Wound healing activity of Malva sylvestris and Punica granatum in alloxan-induced diabetic rats.

    Pirbalouti, Abdollah Ghasemi; Azizi, Shahrzad; Koohpayeh, Abed; Hamedi, Behzad

    2010-01-01

    The flowers of Malva sylvestris Linn. (Malvaceae) and Punica granatum Linn. (Punicaceae) are important medicinal plants in Iranian traditional medicine (Unani) whose have been used as remedy against edema, bum, wound and for their carminative, antimicrobial and anti-inflammatory activities. The diethyl ether extract of M. sylvestris and P. granatum flowers were used to evaluate the wound healing activity at 200 mg/kg/day dose in alloxan-induced diabetic rats. Wounds were induced in Wister rats divided into six groups as following; Group I, normal rats were treated with simple ointment base. Group II, diabetic rats were treated with simple ointment base (control). Groups III and IV, diabetic rats were treated with simple ointment base containing of extracts (diabetic animals), Groups V, diabetic rats were treated with simple ointment base containing of mixed extracts (1:1), Group VI, diabetic rats received the standard drug (nitrofurazone). The efficacy of treatment was evaluated based on wound area relative and histopathological characteristics. The extract-treated diabetic animals showed significant reduction in the wound area when compared with control. Also, histological studies of the tissue obtained on days 9th and 18th from the extract-treated by extract of M. sylvestris showed increased well organized bands of collagen, more fibroblasts and few inflammatory cells. These findings demonstrate that extract of M. sylvestis effectively stimulates wound contraction as compared to control group and other groups. M. sylvestris accelerated wound healing in rats and thus supports its traditional use. PMID:20873419

  14. Bioactivity of Nonedible Parts of Punica granatum L.: A Potential Source of Functional Ingredients.

    Rummun, Nawraj; Somanah, Jhoti; Ramsaha, Srishti; Bahorun, Theeshan; Neergheen-Bhujun, Vidushi S

    2013-01-01

    Punica granatum L. has a long standing culinary and medicinal traditional use in Mauritius. This prompted a comparative study to determine the bioefficacy of the flower, peel, leaf, stem, and seed extracts of the Mauritian P. granatum. The flower and peel extracts resulting from organic solvent extraction exhibited strong antioxidant activities which correlated with the high levels of total phenolics, flavonoids, and proanthocyanidins. The peel extract had the most potent scavenging capacity reflected by high Trolox equivalent antioxidant capacity value (5206.01 ± 578.48 μmol/g air dry weight), very low IC50 values for hypochlorous acid (0.004 ± 0.001 mg air dry weight/mL), and hydroxyl radicals scavenging (0.111 ± 0.001 mg air dry weight/mL). Peel extracts also significantly inhibited S. mutans (P flower extract exhibited high ferric reducing, nitric oxide scavenging, and iron (II) ions chelation and significantly inhibited microsomal lipid peroxidation. Furthermore, it showed a dose-dependent inhibition of xanthine oxidase with an IC50 value of 0.058 ± 0.011 mg air dry weight/mL. This study showed that nonedible parts of cultivated pomegranates, that are generally discarded, are bioactive in multiassay systems thereby suggesting their potential use as natural prophylactics and in food applications. PMID:26904607

  15. Bioactivity of Nonedible Parts of Punica granatum L.: A Potential Source of Functional Ingredients

    Nawraj Rummun

    2013-01-01

    Full Text Available Punica granatum L. has a long standing culinary and medicinal traditional use in Mauritius. This prompted a comparative study to determine the bioefficacy of the flower, peel, leaf, stem, and seed extracts of the Mauritian P. granatum. The flower and peel extracts resulting from organic solvent extraction exhibited strong antioxidant activities which correlated with the high levels of total phenolics, flavonoids, and proanthocyanidins. The peel extract had the most potent scavenging capacity reflected by high Trolox equivalent antioxidant capacity value ( μmol/g air dry weight, very low IC50 values for hypochlorous acid ( mg air dry weight/mL, and hydroxyl radicals scavenging ( mg air dry weight/mL. Peel extracts also significantly inhibited S. mutans (, S. mitis (, and L. acidophilus ( growth compared to ciprofloxacin. The flower extract exhibited high ferric reducing, nitric oxide scavenging, and iron (II ions chelation and significantly inhibited microsomal lipid peroxidation. Furthermore, it showed a dose-dependent inhibition of xanthine oxidase with an IC50 value of  mg air dry weight/mL. This study showed that nonedible parts of cultivated pomegranates, that are generally discarded, are bioactive in multiassay systems thereby suggesting their potential use as natural prophylactics and in food applications.

  16. Preventive Effect of Three Pomegranate (Punica granatum L.) Seeds Fractions on Cerulein-Induced Acute Pancreatitis in Mice

    Minaiyan, Mohsen; Zolfaghari, Behzd; Taheri, Diana; Gomarian, Mahdi

    2014-01-01

    Background: Acute pancreatitis (AP) refers to afflicted inflammation of pancreas with unfavorable adverse effects and developed multiple organ failures. Unfortunately, there is not a certain therapeutic method for this disease. Oxidative stress has a serious role in the pathogenesis of AP. Thus, decreasing of oxidative stress may prevent induction and progression of AP. Punica granatum L. has been extensively used in traditional medicine and possesses various active biological elements. Due t...

  17. Antimicrobial Activity of Six Pomegranate (Punica granatum L.) Varieties and Their Relation to Some of Their Pomological and Phytonutrient Characteristics

    Nurcan Erbil; Kenan S. Dayisoylu; Mustafa Ozgen; Ahmet D. Duman; Coskun Durgac

    2009-01-01

    Arils from six pomegranate (Punica granatum L.) varieties grown in the Mediterranean region of Turkey were tested for their antimicrobial properties by the agar diffusion and minimum inhibitory concentration (MIC) methods against seven bacteria: (Bacillus megaterium DSM 32, Pseudomonas aeruginosa DSM 9027, Staphylococcus aureus Cowan 1, Corynebacterium xerosis UC 9165, Escherichia coli DM, Enterococcus faecalis A10, Micrococcus luteus LA 2971), and threefungi (Kluvyeromyces marxianus A230, Rh...

  18. Effect of Punica granatum Linn. (flowers) on blood glucose level in normal and alloxan-induced diabetic rats.

    Jafri, M A; Aslam, M; Javed, K; Singh, S

    2000-06-01

    'Gulnar farsi', male abortive flowers of Punica granatum L., are used for the treatment of diabetes mellitus in Unani medicine. Oral administration of its aqueous-ethanolic (50%, v/v) extract led to significant blood glucose lowering effect in normal, glucose-fed hyperglycaemic and alloxan-induced diabetic rats. This effect of the extract was maximum at 400 mg/kg, b.w. PMID:10837992

  19. EFFECT OF AQUEOUS EXTRACT OF PUNICA GRANATUM FLOWER ON BIOMARKERS AND ECG CHANGES IN ISOPROTERENOL INDUCED MYOCARDIAL INFARCTION IN RATS

    Khatib N. A.; Patel Jignesh; Medi Swathi

    2011-01-01

    The present study was designed to investigate the effect of aqueous extract of Punica granatum flower (PG) against isoproterenol (ISO) induced myocardial infarction (MI) in rats by studying cardiac markers and electrocardiographic changes. MI was induced in rats by subcutaneous injection of ISO (150mg/kg b.w) at an interval of 24 hours for 2 days. ISO treated rats showed significant increase in cardiac markers such as Lactate dehydrogenase (LDH), Creatine kinase (CK-MB), Alanine aminotransfer...

  20. Two UGT84 Family Glycosyltransferases Catalyze a Critical Reaction of Hydrolyzable Tannin Biosynthesis in Pomegranate (Punica granatum)

    Ono, Nadia N.; Xiaoqiong Qin; Wilson, Alexander E.; Gang Li; Li Tian

    2016-01-01

    Hydrolyzable tannins (HTs) play important roles in plant herbivore deterrence and promotion of human health. A critical step in HT production is the formation of 1-O-galloyl-β-D-glucopyranoside (β-glucogallin, ester-linked gallic acid and glucose) by a UDP-glucosyltransferase (UGT) activity. We cloned and biochemically characterized four candidate UGTs from pomegranate (Punica granatum), of which only UGT84A23 and UGT84A24 exhibited β-glucogallin forming activities in enzyme assays. Although ...

  1. HPLC Evaluation of Phenolic Profile, Nutritive Content, and Antioxidant Capacity of Extracts Obtained from Punica granatum Fruit Peel

    Sushil Kumar Middha; Talambedu Usha; Veena Pande

    2013-01-01

    This study revealed polyphenolic content, nutritive content, antioxidant activity, and phenolic profile of methanol and aqueous extracts of Punica granatum peel extract. For this, extracts were screened for possible antioxidant activities by free radical scavenging activity (DPPH), hydrogen peroxide scavenging activity and ferric-reducing antioxidant power (FRAP) assays. The total phenolics and flavonoid recovered by methanolic (MPE) and the water extract (AQPE) were ranged from 185 ± 12.45 t...

  2. A hepatoprotective effect of an aqueous extract of pomegranate ( Punica granatum L. ) rind against acetaminop hen treated rats

    Enas A.M.Khalil

    2004-01-01

    In ancient times Egyptians regarded pomegranate fruit as a symbol of fertility due to the round shape and abundant seeds .They used it to heal many ailments. Pomegranate (El-Ruwmon ) that fruit mentioned in our holy Quran not less than three times, that paid attention for its importance. This investigation aims to evaluate the hepatoprotective activity of an aqueous rind powder extract of pomegranate (Punica granatum L.) in its human therapeutic dose against overdose acetaminophen. Pretreatme...

  3. Rapid and Comprehensive Evaluation of (Poly)phenolic Compounds in Pomegranate (Punica granatum L.) Juice by UHPLC-MSn

    Daniele Del Rio; Alan Crozier; Renato Bruni; Chiara Dall'Asta; Gianni Galaverna; Cristina García-Viguera; Luca Calani; Pedro Mena

    2012-01-01

    The comprehensive identification of phenolic compounds in food and beverages is a crucial starting point for assessing their biological, nutritional, and technological properties. Pomegranate (Punica granatum L.) has been described as a rich source of (poly)phenolic components, with a broad array of different structures (phenolic acids, flavonoids, and hydrolyzable tannins) and a quick, high throughput, and accurate screening of its complete profile is still lacking. In the present work, a me...

  4. ARTEMISIA DRACUNCULUS, PUNICA GRANATUM AND BERBERIS VULGARIS INHIBITORY EFFECTS ON PLATELET ADHESION AND COAGULATION FACTORS IN RATS

    Dr. Razieh Yazdanparast et al

    2012-01-01

    Excessive platelet activity is one of the most important factors responsible for the incidence of cardiovascular diseases and, also, play important role in coagulation cascade. In this study, the comparative effects of methanol extracts of three herbs on adhesion of the activated platelets to fibrinogen coated plates and clotting factors were investigated. Artemisia dracunculus, Punica granatum and Brberis vulgaris are used as blood anti-coagulatory plants in Iranian folk medicine. Platelets ...

  5. Osteogenic potential of punica granatum through matrix mineralization, cell cycle progression and runx2 gene expression in primary rat osteoblasts

    Siddiqui, Sahabjada; Arshad, Mohammad

    2014-01-01

    Background Osteoporosis is one of the prevalent diseases in ageing populations. Due to side effects of many chemotherapeutic agents, there is always a need to search for herbal products to treat the disorder. Punica granatum (PG) represent a potent fruit-bearing medicinal herb which exerted valuable anti-osteoporotic activities. The present study was carried out to validate the in vitro osteogenic effects of the PG seed extract in primary calvarial osteoblast cultures harvested from neonatal ...

  6. Effects of rhaponticum carthamoides versus glycyrrhiza glabra and punica granatum extracts on metabolic syndrome signs in rats

    Dushkin, Michael; Khrapova, Marina; Kovshik, Gennadiy; Chasovskikh, Marina; Menshchikova, Elena; Trufakin, Valeriy; Shurlygina, Anna; Vereschagin, Evgeniy

    2014-01-01

    Background Rhaponticum cathamoides (RC) is an endemic wild Siberian herb with marked medicinal properties that are still poorly understood. The aim of this study is to investigate the therapeutic potential of RC extract (ERC) compared to the effects of Glycyrrhiza glabra (EGG) and Punica granatum extracts (EPG) in a rat model with high-fat diet-(HFD)-induced signs of metabolic syndrome; therefore, this study addresses a significant global public health problem. Methods Six-month-old male Wist...

  7. Draft Genome Sequence of Phosphate-Solubilizing Bacterium Paraburkholderia tropica Strain P-31 Isolated from Pomegranate (Punica granatum) Rhizosphere.

    Kaur, Chandandeep; Selvakumar, Govindan; Ganeshamurthy, Arakalgud Nanjundiah

    2016-01-01

    We report the 8.9 Mb draft genome sequence of phosphate-solubilizing bacterium Paraburkholderia tropica strain P-31, isolated from pomegranate (Punica granatum) rhizosphere. The draft genome sequence of Paraburkholderia tropica strain P-31 consists of 8,881,246 bp with a G+C content of 64.7%, 8,039 protein-coding genes, and 49 RNAs. PMID:27540068

  8. Antifungal efficacy of Punica granatum, Acacia nilotica, Cuminum cyminum and Foeniculum vulgare on Candida albicans: An in vitro study

    Pai Mithun

    2010-01-01

    Full Text Available Background: The establishment and maintenance of oral microbiota is related not only to interbacterial coaggregations but also to interactions of these bacteria with yeasts. Hence, it is important for agents used in the treatment of oral diseases to have antifungal properties for effective therapy. Objective: The main purpose of this study was to evaluate the in vitro antifungal efficacy of Punica granatum, Acacia nilotica, Cuminum cyminum and Foeniculum vulgare on Candida albicans. Materials and Methods: The pomegranate peel is separated, dried and powdered. Fennel, cumin and acacia bark obtained from the tree are powdered. Candida is inoculated at 37˚C and seeded on Sabourauds agar medium. Sterilized filter papers saturated with 30 μl of the extracts are placed on the seeded plates and inoculated at 24 and 48 h. Zones of inhibition on all four sides are measured around the filter paper with a vernier caliper. The experiments were repeated on four plates, with four samples of each extract on one plate for all of the extracts. Results: All the above-mentioned ingredients showed antifungal property, with Punica granatum showing the highest inhibition of Candida albicans with a mean zone of inhibition of 22 mm. P-values <0.05 were obtained for Punica granatum when compared with the other extracts. Conclusion: The results showed the potential use of these products as cheap and convenient adjuvants to pharmaceutical antifungal products.

  9. Evaluation of antidiabetic, hypolipedimic and antioxidant activity of hydroalcoholic extract of leaves and fruit peel of Punica granatum in male Wistar albino rats

    Salwe, Kartik J.; Sachdev, Devender O.; Bahurupi, Yogesh; Kumarappan, Manimekalai

    2015-01-01

    Background: We investigated anti-diabetic, hypolipedimic and antioxidant activity of hydroalcoholic extract from leaves and fruit peel of Punica granatum. Materials and Methods: Streptozotocin induced diabetic Wister rats were used in this study consisting of seven groups of six animals each. Groups (1) normal control, (2) diabetic control, (3) leaves extract 100 mg/kg b.w. of P. granatum, (4) leaves extract 200 mg/kg b.w. of P. granatum, (5) fruit peel extract 100 mg/kg b.w. of P. granatum, ...

  10. Inhibitory Effect of the Punica granatum Fruit Extract on Angiotensin-II Type I Receptor and Thromboxane B2 in Endothelial Cells Induced by Plasma from Preeclamptic Patients.

    Kusumawati, Widya; Keman, Kusnarman; Soeharto, Setyawati

    2016-01-01

    This study aims to evaluate whether the Punica granatum fruit extract modulates the Angiotensin-II Type I receptor (AT1-R) and thromboxane B2 level in endothelial cells induced by plasma from preeclamptic patients. Endothelial cells were obtained from human umbilical vascular endothelial cells. At confluence, endothelial cells were divided into five groups, which included endothelial cells exposed to 2% plasma from normal pregnancy (NP), endothelial cells exposed to 2% plasma from preeclamptic patients (PP), and endothelial cells exposed to PP in the presence of ethanolic extract of Punica granatum (PP + PG) at the following three doses: 14; 28; and 56 ppm. The expression of AT1-R was observed by immunohistochemistry technique, and thromboxane B2 level was done by immunoassay technique. Plasma from PP significantly increased AT1-R expression and thromboxane B2 levels compared to cells treated by normal pregnancy plasma. The increasing of AT1-R expression significantly (P Punica granatum extract. Moreover, the increasing of thromboxane B2 levels significantly (P Punica granatum extract. We further concluded that Punica granatum fruit protects and inhibits the sensitivity of endothelial cells to plasma from preeclamptic patients due to inhibition of AT1-R expression (56 ppm) and reduced thromboxane B2 levels (14 ppm). PMID:26989513

  11. Antidiabetic and antihyperlipidemic effects of ethanolic extract of leaves of Punica granatum in alloxan-induced non-insulin-dependent diabetes mellitus albino rats

    Swarnamoni Das; Sarajita Barman

    2012-01-01

    Objectives: Punica granatum L., (Family: Punicaceae) is used in Indian Unani medicine for treatment of diabetes mellitus. Therefore, the present study was done to evaluate the antidiabetic and antihyperlipidemic effects of ethanolic extract of leaves of P. granatum in alloxan-induced diabetic rats. Materials and Methods: Healthy Wistar albino rats (100-150 g) were divided into four groups of six animals each. Groups A and B received normal saline [(10 ml/kg/day/per oral (p.o.)]; group C ...

  12. Lipid Lowering Effect of Punica granatum L. Peel in High Lipid Diet Fed Male Rats

    Alireza Sadeghipour

    2014-01-01

    Full Text Available Many herbal medicines have been recommended for the treatment of dyslipidemia. The antilipidemic effect of hydroethanolic extract of pomegranate peel (Punica granatum L. was investigated in high lipid diet fed male rats. Intraperitoneally administration of pomegranate peel extract (50, 100, 200, and 300 mg/kg body weight for 23 days on the levels of serum cholesterol, triglycerides, LDL, HDL, alkaline phosphatase (AP, aspartate aminotransferase (AST, and alanine aminotransferase (ALT in high lipid diet fed male rats was evaluated. Treatment of pomegranate extract decreased body weight in treated rats, significantly. Administration of the plant extract significantly decreased serum total cholesterol, triglycerides, LDL-C, alkaline phosphatise, AST, and ALT levels, whereas it increased serum HDL-C in high lipid diet fed rats in comparison to saline control group. Also, histopathological study showed that treatment of pomegranate peel extract attenuates liver damage in high lipid diet fed rats in comparison to saline group. It is concluded that the plant should be considered as an excellent candidate for future studies on dyslipidemia.

  13. Protective Effect of Pomegranate (Punica Granatum), Juice in Rats Consuming Aspartame Peroxidation and Antioxidant Status

    Pomegranate (Punica granatum) has been traditionally used as medicine in many countries due to its high antioxidant activity, which has been related to beneficial health properties. Aspartame (ASP) is a widely used artificial sweetener that may be harmful at abuse levels. The objective of this study was to evaluate the potential efficacy of pomegranate juice (PJ) in protecting tissues from the possible damage induced by aspartame. ASP treated rats were given ASP, by gavages, at a dose of 250 mg/kg /day for 28 days. PJ-ASP treated rats were given PI at a dose of 1ml /kg body weight/day along with ASP. The data obtained indicate that ASP administration results in no significant change in the concentration of serum triglycerides (TG), total cholesterol (Tc), low-density lipoprotein (LDL-c), high density lipoprotein (HDL-c) and glucose while significant decreases have been recorded for insulin. The results demonstrated also that aspartame promotes lipid peroxidation and decreases the level of antioxidants superoxide dismutase (SOD) and catalase (Cat) activities and reduced glutathione (GSH) contents in serum and liver tissues. Significant elevations in the activities of serum aspartate transaminase (AST), serum alanine transaminase (AL T) and alkaline phosphatase (ALP) were also observed. Administration of PI in parallel with aspartame protected rats from aspartame-induced oxidative injury and ameliorated liver function

  14. Triterpenes as uncompetitive inhibitors of α-glucosidase from flowers of Punica granatum L.

    Salah El Dine, Riham; Ma, Qiong; Kandil, Zeinab A; El-Halawany, Ali M

    2014-01-01

    The α-glucosidase and maltase inhibitory effects of Punica granatum L. flowers (PGF) were investigated. The methanol extract (PGFMe), n-hexane extract (PGFH), chloroform extract (PGFC) and the remaining water fraction (PGFW) were assayed for their α-glucosidase and maltase inhibitory effects. PGFW showed potent α-glucosidase inhibition with IC₅₀ of 0.8 μg/mL followed by PGFMe (IC₅₀ of 4.0 μg/mL) then PGFC (IC₅₀ of 5.21 μg/mL) in comparison to acarbose (0.9 μM). Due to its selectivity towards α-glucosidase, PGFC was subjected to bioactivity-guided isolation of its main active constituents. Five known compounds (1-5) were identified as β-sitosterol (1), oleanolic acid (2), ursolic acid (3), p-coumaric acid (4) and apigenin (5). Ursolic and oleanolic acids showed potent α-glucosidase inhibition (IC₅₀ of 39.0 and 35.0 μM, respectively), while they did not show significant maltase inhibition. Kinetic study using the double Lineweaver-Burk plot revealed that ursolic acid uncompetitively inhibited α-glucosidase in comparison with acarbose as a competitive inhibitor. PMID:24956202

  15. Punica granatum peel extract protects against ionizing radiation-induced enteritis and leukocyte apoptosis in rats

    Radiation-induced enteritis is a well-recognized sequel of therapeutic irradiation. Therefore we examined the radioprotective properties of Punica granatum peel extract (PPE) on the oxidative damage in the ileum. Rats were exposed to a single whole-body X-ray irradiation of 800 cGy. Irradiated rats were pretreated orally with saline or PPE (50 mg/kg/day) for 10 days before irradiation and the following 10 days, while control rats received saline or PPE but no irradiation. Then plasma and ileum samples were obtained. Irradiation caused a decrease in glutathione and total antioxidant capacity, which was accompanied by increases in malondialdehyde levels, myeloperoxidase activity, collagen content of the tissue with a concomitant increase 8-hydroxy-2'-deoxyguanosine (an index of oxidative DNA damage). Similarly, pro-inflammatory cytokines (TNF-α, IL-1β and IL-6) and lactate dehydrogenase were elevated in irradiated groups as compared to control. PPE treatment reversed all these biochemical indices, as well as histopathological alterations induced by irradiation. Furthermore, flow cytometric measurements revealed that leukocyte apoptosis and cell death were increased in irradiated animals, while PPE reversed these effects. PPE supplementation reduced oxidative damage in the ileal tissues, probably by a mechanism that is associated with the decreased production of reactive oxygen metabolites and enhancement of antioxidant mechanisms. Adjuvant therapy of PPE may have a potential to support a successful radiotherapy by protecting against radiation-induced enteritis. (author)

  16. Components Analysis of Punica granatum Linn. Seed%石榴籽成分分析

    杭志奇; 韩清波; 许景松

    2010-01-01

    [目的]对石榴(Punica granatum Linn.)籽主要成分进行分析.[方法]测定石榴籽水分、蛋白质、脂肪、灰分、黄酮类物质和单宁含量,并分析石榴籽油脂肪酸组成成分和干燥脱脂石榴籽蛋白质中氨基酸成分.[结果]石榴籽中蛋白质和脂肪含量相对较高,其含量分别为13.62%、20.29%,石榴籽油中含有8种不饱和脂肪酸和4种饱和脂肪酸,其中不饱和脂肪酸相对含量为92.22%,9,12,15-十八碳三烯酸占82.76%.石榴籽蛋白质中氨基酸组成较完全,其中必需氨基酸含量为31.98%.[结论]该研究可为石榴籽的进一步利用奠定理论基础.

  17. In Vitro Antifungal Activity of Various Persian Cultivars of Punica granatum L. Extracts Against Candida species

    Bassiri-Jahromi

    2015-08-01

    Full Text Available Background Resistance of Candida species to antifungal agents has potentially serious implications for management of infections. Candida species are now the fourth most common organisms isolated from hospitalized patients. Prevention and control of these infections will require new antimicrobial agents. Plant-derived antifungal agents have always been a source of novel therapeutics. Objectives The aim of this study was to investigate the antifungal effect of pomegranate peel and pulp extracts against Candida species. Materials and Methods Pomegranate pulp and peel were dried and powdered separately. The dried powders were extracted using a soxhlet extractor. The antifungal effect of pomegranate peel and pulp extracts were determined in vitro by using the minimum inhibitory concentration (MIC against five standard species, including Candida albicans (ATCC 10231, Candida parapsilosis (ATCC 22019, Candida tropicalis (ATCC 750, Candida glabrata (PTCC 5297 and Candida krusei (PTCC 5295. Results Maximum inhibitions were attributed to peel extract of the pomegranate cultivar against Candida species. The greatest antifungal inhibition among the eight different cultivars was observed for sour malas, sour white peel and sour summer extracts respectively, against the five Candida strains. The antifungal activity of pulp extracts against Candida species was somewhat negative. Conclusions Our work suggested that pomegranate (Punica granatum L. peel has potential antifungal activity against Candidiasis, and it is an attractive option for the development of new management strategies for candidiasis.

  18. Efeito antibacteriano e antiaderente in vitro do extrato da Punica granatum Linn. sobre microrganismos do biofilme dental In vitro antibacterial and antiadherence effect of the extract of the Punica granatum Linn. upon dental biofilm microrganisms

    Jozinete V. Pereira; Maria S. Vieira Pereira; Fábio C. Sampaio; Maria C. Correia Sampaio; Pollianna M. Alves; Cristina R. Ferreira de Araújo; Jane S. Higino

    2006-01-01

    Nesta pesquisa foi avaliada a atividade antimicrobiana e a capacidade de inibição da síntese de glucano in vitro do extrato da casca do fruto da romã (Punica granatum Linn.) sobre linhagens bacterianas de Streptococcus mitis, Streptococcus mutans, Streptococcus sanguis, Streptococcus sobrinus e Lactobacillus casei. Os ensaios foram realizados pelas técnicas de ágar-difusão em placas para determinação da Concentração Inibitória Mínima (CIM) e técnica dos tubos inclinados para determinação da C...

  19. Amelioration of radiation induced decrease in activity of catalase and superoxide dismutase in mouse liver by Punica granatum

    Ionizing radiation generates reactive oxygen species (ROS) in irradiated tissue. Cells of liver have their own defence system, the antioxidant system to deactivate ROS. Antioxidant system includes enzymatic and non-enzymatic components. Liver is rich in endogenous antioxidants and related enzymes. Catalase and Superoxide dismutase (SOD) are powerful antioxidant enzymes. In the present study Punica granatum fruit rind Ethanol extract (PGFRE) was tested against 60Co gamma radiation induced alteration in Swiss albino mouse. Healthy adult (25±2) Swiss albino mouse were selected and divided into four groups. The first group was sham irradiated. The second group was irradiated with 8 Gy 60Co gamma radiation only and served as control. The third group was administered with Ethanol extract of Punica granatum fruit rind one hour before irradiation at the dose rate of 10 mg/kg body weight orally. Animals were exposed to 8 Gy 60Co gamma radiation. Fourth group was administered with Ethanol extract of Punica granatum fruit rind at the dose rate of 10 mg/kg body weight. Mice were sacrificed at various post irradiation intervals and liver was removed, weighed and analysed biochemically for Catalase and SOD activity. Catalase and SOD activity decreased up till 7th post irradiation day in 8 Gy irradiated group than normal. In PGFRE pretreated irradiated group catalase and SOD activity were higher than the corresponding control group at all the intervals. These results indicate that PGFRE extract protects damage to the catalase and SOD activity in liver of Swiss albino mouse against lethal dose of gamma radiation. (author)

  20. Comparison of antihyperlipidaemic activity of eugenia jambolana fruit with punica granatum fruit in diet induced hyperlipidaemic rats

    Objective: To compare the antihyperlipidemic effects of Eugenia Jambolana fruit pulp with Punica Granatum fruit in diet induced hyperlipidaemic rats at the same dose level. Methods: An experimental randomized control study was conducted on seventy five male albino rats over a period of 14 weeks in University of Health Sciences Lahore. They were divided into five groups labelled A, B, C, D and E with fifteen rats in each group. Group A was kept as normal control, groups B, C, D and E were given hyperlipidaemic diet for six weeks. In group B no further intervention was done, group C and D were given ethanolic extract of Eugenia Jambolana and Punica Granatum respectively for eight weeks. Group E was given combination of both for same duration. Serum total cholesterol (TC), high density lipoprotein cholesterol (HDL-c), lowdensity lipoprotein cholesterol (LDL-c) and triglycerides (TG) were measured at zero, six and fourteen weeks. Results: At fourteenth week significant reductions in TC, LDL-c and TG and a rise in HDL-c was observed in interventional groups C, D and E as compared to experimental hyperlipidaemic control group B (p 0.57, p > 0.22, p > 0.56, p > 0.76, respectively. On sixth week, there was no significant difference between groups B, C, D and E (p > 0.05). However, 15 rats of group A had significant lower levels of cholesterol, high density lipoproteins, low density lipoproteins and triglycerides when compared to 60 rats of groups B, C, D and E (p<0.05). Conclusion: In male albino rats combination of ethanolic extracts of Eugenia Jambolana and Punica Granatum fruit pulps was most effective in lowering serum total cholesterol and triglycerides while decrease in low density lipoprotein cholesterol and rise in high density lipoprotein cholesterol was same as the extracts given alone. (author)

  1. Inhibitory Effects of Two Varieties of Tunisian Pomegranate (Punica granatum L.) Extracts on Gastrointestinal Transit in Rat.

    Souli, Abdelaziz; Sebai, Hichem; Rtibi, Kais; Chehimi, Latifa; Sakly, Mohsen; Amri, Mohamed; El-Benna, Jamel; Marzouki, Lamjed

    2015-09-01

    The present study was undertaken to determine whether total and methanol juice extracts of two Tunisian Pomegranate (Punica granatum L.) varieties (Garsi and Gabsi) protect against diarrhea as well as their effects on gastrointestinal transit (GIT) in healthy rats. In this respect, male Wistar rats were used and divided into control- and pomegranate-treated groups. The antidiarrheal activity was evaluated using the castor oil-induced diarrhea method and the GIT was assessed using charcoal meal. Our results showed that total and methanol P. granatum juice extracts produced a significant dose-dependent protection against castor oil-induced diarrhea. Pomegranate extracts and juice also decreased the GIT significantly and dose dependently. Importantly, the Garsi variety appeared to be more effective than the Gabsi variety on these two parameters. These findings suggest that pomegranate extracts have a potent antidiarrheal property in rats confirming their efficiency in the Tunisian traditional medicine. PMID:25775227

  2. New Development on Pharmacological Effects ofPunica Granatum L.%石榴药理研究新进展

    刘宇; 蔡霞; 曾勇; 王平; 孟宪丽; 张艺

    2015-01-01

    本文主要对近年来国内外石榴的药理研究进展进行综述.石榴药用历史悠久,不同部位在中医药与民族医药中应用广泛,其化学成分以鞣质类、黄酮类、生物碱和有机酸化合物为主,具有明显的药理活性.近年来,有关石榴的抗菌抗病毒、降血糖、抗肿瘤、调血脂及抗氧化、免疫调节等药理研究进展迅速.通过整理归纳并科学的分析石榴的功效及其新的药理学研究成果,以期能对石榴的研究、临床应用及相关产品的开发利用提供依据.%This article reviewed pharmacological study development of Punica granatum L. both at home and abroad in recent years. P. granatum has a long medical usage history. Different parts of P. granatum have wide applications in both traditional Chinese medicine (TCM) and other ethnic medicine. Its main chemical compositions were tannins, flavonoids, alkaloids and organic acids. It has obvious pharmacological activities. In recent years, the pharmacological research progress on P. granatum in terms of antibacterial, antiviral, hypoglycemic, antitumor, adjusting blood lipids, antioxidant, and immunoregulation has rapid development. The scientific collection and analysis on effects and new pharmacological research results of P. granatum are hoped to provide references for the study, clinical application, development and utilization of P. granatum and its products.

  3. Antispasmodic Effects of Aqueous and Hydroalcoholic Punica granatum Flower Extracts on the Uterus of Non-pregnant Rats

    Ahangarpour, Akram; Heidari, Razieh; Abdolahzadeh, Mahsa; Oroojan, Ali Akbar

    2012-01-01

    Background Punica granatum Linn. (PG) is native to the Mediterranean region. Its flower exhibited antioxidant activity. The present study attempt to investigate the effect of these extract on uterine contraction and its possible mechanism(s). Methods Thirty five female Wistar rats (200–300 g) at estrous phases of cycle was examined in this study; pieces of virgin adult rat uterus (1.5 cm) were suspended in an organ bath containing 10 ml of De Jalon solution at 29 °C. Tissue contractility was ...

  4. Amelioration of Diabetes and Painful Diabetic Neuropathy by Punica granatum L. Extract and Its Spray Dried Biopolymeric Dispersions

    Raafat, K.; Samy, W

    2014-01-01

    Aims. To evaluate the effect of Punica granatum (Pg) rind extract and its spray dried biopolymeric dispersions with casein (F1) or chitosan (F2) against Diabetes mellitus (DM) and diabetic neuropathy (DN). Methods. We measured the acute (6 h) and subacute (8 days) effect of various doses of Pg, F1, and F2 and the active compounds on alloxan-induced DM mouse model. We evaluated DN utilizing latency tests for longer period of time (8 weeks). In addition, the in vivo antioxidant activity was ass...

  5. Antibiotic activity of the extract of Punica granatum Linn. over bovine strains of Staphylococcus aureus Atividade antimicrobiana do extrato de Punica granatum Linn. em linhagens de Staphylococcus aureus de origem bovina

    Maria A. R. Silva

    2008-06-01

    Full Text Available Human and veterinary medicines have not been so well succeeded in order to achieving their goals concerning the treatment of infections for long term caused by Staphylococcus aureus linked to resistance development against antibiotic agents. The antibiotic activity of the Punica granatum Linn. fresh fruit pericarp extract was evaluated by the agar diffusion method on 38 S. aureus strains, isolated from apparently healthy lactating cows in farms situated in counties of the semi-arid region of the State of Paraíba, Brazil to determine the minimum inhibitory concentration (MIC. Twenty-two of the thirty-eight strains are penicillin-resistant (PRSA. The extract of P. granatum presented potential antibiotic action over all the assayed strains, forming 10 to 36 mm diameter inhibition zones. This paper's results claim the effectiveness of the extract of P. granatum as a potential antibacterial agent on S. aureus, and display the significance of evaluating new substances with antimicrobial potential, which can contribute to alternative therapeutics for veterinary and medicine.A medicina humana e veterinária tem falhado no tratamento de infecções em longo prazo causadas por Staphylococcus aureus associadas ao desenvolvimento de resistência a agentes antimicrobianos. A atividade antimicrobiana do extrato da casca do fruto de Punica granatum Linn. foi avaliada sobre 38 linhagens de S. aureus de origem bovina para a determinação da concentração inibitória mínima (CIM. Das 38 linhagens ensaiadas, 22 são resistentes à penicilina.(PRSA. O extrato de P. granatum apresentou potencial ação antimicrobiana sobre todas as linhagens ensaiadas formando halos de inibição variando de 10 a 36 mm de diâmetro. Os resultados deste estudo confirmam a eficácia do extrato de P. granatum como potencial agente antibacteriano sobre S. aureus e demonstram a importância de se avaliar novas substâncias com potencial antimicrobiano, o que pode contribuir para a

  6. Antioxidant Activity of Some Extracts from GAMMA Irradiated Pomegranate (Punica granatum L.) Peel and Seed

    The present study aims to evaluate the antioxidant activity of pomegranate (Punica granatum L.) peel and seed (obtained as waste from juice extraction) using different solvents as diethyl ether, ethyl acetate, ethanol 50 ⁒, ethanol 80⁒: methanol 50⁒, methanol 80⁒ and distilled water. The measurements of the antioxidant activity of all extracts were carried out using a radical scavenging activity against 2,2',-diphenyl-1-picrylhydrazyl (DPPH), β-Carotene⁒linoleic acid bleaching and ferric reducing antioxidant power (FRAP). Moreover, the effect of gamma irradiation at dose levels of 3, 6 and 9 kGy on, antioxidant activity of the best pomegranate peel and seed samples that possessed highest antioxidant activity was investigated. Results showed that ethanolic 50⁒ peel extract had a higher total phenolic contents (TPC) and total flavonoid contents (TFC) in both peel and seed, (9323.17 mg gallic acid equivalent (GAE) 100 g-1, 2998.05 mg quercetin equivalent (QE) 100 g-1 and 352.09 mg GAE 100 g-1,106.78 mg QE 100 g-1 dry weight (DW), respectively than other extracts. Ethanolic 50⁒ extracts showed higher antioxidant activity than other peel and seed extracts. In addition, ethanolic 50⁒ extract of irradiated pomegranate peel and seed at dose level of 6 kGy extract had higher TPC, TFC and antioxidant activity compared to other doses. Thus, ethanolic 50⁒ extract of irradiated pomegranate peel and seed at 6 kGy may be considered as a good source of natural compounds with-antioxidant activity which could be suitable as potential ingredient for food products.

  7. Lipid composition of seed oils of different pomegranate (Punica granatum L. cultivars from Spain

    Luana Fernandes

    2015-04-01

    Full Text Available Pomegranate (Punica granatum L. is an ancient fruit tree traditionally cultivated in the Near and Middle East. Presently, its most important growing regions include Afghanistan, Iran, Israel, USA, Italy and Spain, the latter country the largest European exporter. The pomegranate fruit can be divided into several anatomical compartments: outside peel, inside peel, and arils (pulp and seeds, the last part being usually used for consumption as is or for juice, jams and jellies production. Even though pomegranate seeds are an industrial by-product, recent reports have highlighted their potential use as a source of oil with beneficial chemical attributes. Therefore, the main objective of the present work was to characterize the seed oil of nine European pomegranate varieties, collected in Spain, for their fatty acid and vitamin E compositions. All seed lipid fractions consisted mainly of punicic acid (c9,t11,c13 C-18:3, ranging between 77.3% and 83.6% of total fatty acids, followed by small amounts of linoleic acid (C18:2n6, oleic acid (C18:1n9 and palmitic acid (C16:0. Regarding vitamin E composition, α-, γ-, δ-tocopherols were found in all pomegranate seed oils, but mainly γ-tocopherol, with total tocopherols ranging from 174.5 to 627.3 mg/100g oil.The richness of these pomegranate varieties seed oils in punicic acid, a conjugated linolenic acid with interesting anti-carcinogenic activity, and the elevated amount of tocopherols on the extracted lipids, of technological and nutritional relevance, make this by-product interesting for further exploitation.

  8. COMPORTAMENTO DE SEMENTES DE ROMÃ (Punica granatum L. SUBMETIDAS À FERMENTAÇÃO E SECAGEM

    LOPES KILSON PINHEIRO

    2001-01-01

    Full Text Available Sementes de romã (Punica granatum L. foram submetidas a diferentes períodos de fermentação (0; 24; 48; 72 e 96 horas, com e sem secagem. Avaliaram-se suas qualidades física e fisiológica, através das determinações do grau de umidade, peso de 100 sementes, porcentagem de emergência e velocidade de emergência de plântulas (IVE. O delineamento experimental adotado foi inteiramente casualizado, em esquema fatorial, onde os cinco períodos de fermentação frente às duas condições (com e sem secagem constituíram os tratamentos. Sementes submetidas ao maior período de fermentação apresentaram sarcotestas mais degradadas, favorecendo, conseqüentemente, uma melhor absorção de água, resultando numa porcentagem de emergência de 55% e IVE de 0,38, em 72 horas de fermentação. A secagem das sementes após fermentação promoveu uma menor porcentagem de emergência e IVE, apesar de se verificar um aumento de ambos, quando as sementes permaneceram em fermentação por um maior período. O comportamento verificado nas sementes de romã frente aos tratamentos empregados parece estar associado a fenômenos de dormência ou sensibilidade à secagem, característica esta, de sementes recalcitrantes.

  9. ARTEMISIA DRACUNCULUS, PUNICA GRANATUM AND BERBERIS VULGARIS INHIBITORY EFFECTS ON PLATELET ADHESION AND COAGULATION FACTORS IN RATS

    Dr. Razieh Yazdanparast et al

    2012-10-01

    Full Text Available Excessive platelet activity is one of the most important factors responsible for the incidence of cardiovascular diseases and, also, play important role in coagulation cascade. In this study, the comparative effects of methanol extracts of three herbs on adhesion of the activated platelets to fibrinogen coated plates and clotting factors were investigated. Artemisia dracunculus, Punica granatum and Brberis vulgaris are used as blood anti-coagulatory plants in Iranian folk medicine. Platelets were prepared and incubated with different concentration of the test samples (50-200 μg/ml for 60 min. The treated and un-treated platelets were then activated with thrombin (0.25U/ml and their adhesions to fibrinogen coated plates were investigated. Based on obtained data, the methanol extract of Artemisia dracunculus, Brberis vulgaris and Punica granatum at a concentration of 200 μg /ml reduced platelet adhesion to coated wells by 35%, 25% and 20%, respectively. In addition, the effects of the crude extracts of each plant on atherogenic lipoproteins were also examined. The results indicated that the LDL and cholesterol concentration were dramatically reduced by 56% and 36%, respectively, by B. vulgaris. This result provided the scientific basis for the traditional use of A.dracunculus and B. vulgaris in treatment of cardiovascular related disorders.

  10. Evaluation of Protective Effect of Hydro-alcoholic Extract of Fruit Peels of Punica granatum Linn against Ulcerative Colitis in Rats

    Ashar Kalangottil

    2014-07-01

    Full Text Available The study was designed to evaluate the protective effect of hydro-alcoholic extract of fruits peels of Punica granatum Linn. against acetic acid and trinitrobenzene sulfonic acid (TNBS induced ulcerative colitis in rats. Acute oral toxicity study was performed to find out the test dose according to OECD guidelines 425 and hydro-alcoholic extract of P. granatum fruit peel (PGPE was found to be safe at a dose of 2000 mg/kg body weight. The animals pretreated with hydro-alcoholic extract of P. granatum fruit peel (200 mg/kg and 400 mg/kg respectively significantly restored the altered hematological, biochemical parameters to normal levels when compared with control. The protective effect of P. granatum peel extract was comparable to standard sulfasalazine. The findings of the present study revealed that the hydro-alcoholic extract of P. granatum fruit peel possessed a dose dependent significant inhibitory activity against ulcerative colitis. The results obtained established the efficacy of the Punica granatum fruit peel against inflammatory bowel diseases possibly by its anti-inflammatory and antioxidant properties.

  11. Effect of Punica granatum L. Flower Water Extract on Five Common Oral Bacteria and Bacterial Biofilm Formation on Orthodontic Wire.

    Elahe Vahid Dastjerdi

    2014-12-01

    Full Text Available Use of herbal extracts and essences as natural antibacterial compounds has become increasingly popular for the control of oral infectious diseases. Therefore, finding natural antimicrobial products with the lowest side effects seems necessary. The present study sought to assess the effect of Punica granatum L. water extract on five oral bacteria and bacterial biofilm formation on orthodontic wire.Antibacterial property of P. granatum L. water extract was primarily evaluated in brain heart infusion agar medium using well-plate method. The minimum inhibitory concentration and minimum bactericidal concentration were determined by macro-dilution method. The inhibitory effect on orthodontic wire bacterial biofilm formation was evaluated using viable cell count in biofilm medium. At the final phase, samples were fixed and analyzed by Scanning Electron Microscopy.The growth inhibition zone diameter was proportional to the extract concentration. The water extract demonstrated the maximum antibacterial effect on Streptococcus sanguinis ATCC 10556 with a minimum inhibitory concentration of 6.25 mg/ml and maximum bactericidal effect on S. sanguinis ATCC 10556 and S. sobrinus ATCC 27607 with minimum bactericidal concentration of 25 mg/ml. The water extract decreased bacterial biofilm formation by S. sanguinis, S. sobrinus, S. salivarius, S. mutans ATCC 35608 and E. faecalis CIP 55142 by 93.7-100%, 40.6-99.9%, 85.2-86.5%, 66.4-84.4% and 35.5-56.3% respectively.Punica granatum L. water extract had significant antibacterial properties against 5 oral bacteria and prevented orthodontic wire bacterial biofilm formation. However, further investigations are required to generalize these results to the clinical setting.

  12. Evaluation of Protective Effect of Hydro-alcoholic Extract of Fruit Peels of Punica granatum Linn against Ulcerative Colitis in Rats

    Ashar Kalangottil; Karunakar Hegde; Naseeb K M

    2014-01-01

    The study was designed to evaluate the protective effect of hydro-alcoholic extract of fruits peels of Punica granatum Linn. against acetic acid and trinitrobenzene sulfonic acid (TNBS) induced ulcerative colitis in rats. Acute oral toxicity study was performed to find out the test dose according to OECD guidelines 425 and hydro-alcoholic extract of P. granatum fruit peel (PGPE) was found to be safe at a dose of 2000 mg/kg body weight. The animals pretreated with hydro-alcoholic extract of P....

  13. In vitro assessment of the antimicrobial effects of pomegranate (Punica granatum L. peel decoction on saliva samples

    Solon José de Oliveira Leite

    2014-01-01

    Full Text Available Several products have been developed to eliminate or reduce potential pathogenic microorganisms of the oral microbiome. The continuous use of these synthetic products can result in side effects such as vomiting, diarrhea, darkening of the teeth and the induction of microbial resistance. Pomegranate (Punica granatum peel decoction was tested to assess its antimicrobial activity. In vitro analysis showed the decoction had antimicrobial activity against strains of Pseudomonas aeruginosa and Candida albicans, but none was detected against Enterococcus faecalis. When tested on saliva samples from children, the decoction showed great potential in reducing the load of microorganisms, the inhibition haloes produced with saliva samples being similar to those of the antimicrobial control (0.12% chlorhexidine. The pomegranate peel decoction in water could thus provide a promising source for developing solutions for use against oral diseases.

  14. EFFECT OF AQUEOUS EXTRACT OF PUNICA GRANATUM FLOWER ON BIOMARKERS AND ECG CHANGES IN ISOPROTERENOL INDUCED MYOCARDIAL INFARCTION IN RATS

    Khatib N.A

    2011-03-01

    Full Text Available The present study was designed to investigate the effect of aqueous extract of Punica granatum flower (PG against isoproterenol (ISO induced myocardial infarction (MI in rats by studying cardiac markers and electrocardiographic changes. MI was induced in rats by subcutaneous injection of ISO (150mg/kg b.w at an interval of 24 hours for 2 days. ISO treated rats showed significant increase in cardiac markers such as Lactate dehydrogenase (LDH, Creatine kinase (CK-MB, Alanine aminotransferase (ALT, Aspartate aminotransferase (AST in serum. Altered ECG pattern with ST segment elevation, which conforms the MI. Oral pretreatment with PG at 400mg/kg and Vitamin E (100mg/kg as a standard daily for a period of 28 days showed significant decrease in serum cardiac marker enzymes level and ECG alterations. Thus the result suggests that PG has cardioprotective effect in ISO induced myocardial infracted rats.

  15. Mucoadhesive polyethylenimine-dextran sulfate nanoparticles containing Punica granatum peel extract as a novel sustained-release antimicrobial.

    Tiyaboonchai, Waree; Rodleang, Ingdao; Ounaroon, Anan

    2015-06-01

    Mucoadhesive polyethylenimine-dextran sulfate nanoparticles (PDNPs) were developed for local oral mucosa delivery. Punica granatum peel extract (PGE) was loaded into PDNPs for oral malodor reduction and caries prevention. PDNPs were constructed using the polyelectrolyte complexation technique employing oppositely charged polymers polyethylenimine (PEI) and dextran sulfate (DS), with PEG 400 as a stabilizer. Under optimal conditions, spherical particles of ∼ 500 nm with a zeta potential of ∼+28 mV were produced. Up to 98%, drug entrapment efficiency was observed. The mass ratio of PEI:DS played a significant role in controlling particle size and entrapment efficacy. PDNPs shown to be a good mucoadhesive drug delivery system as confirmed by ex vivo wash off test. In vitro dissolution studies revealed that PGE-loaded PDNPs manifested a prolong release characteristic with a burst release within 5 min. In addition, they remained effectively against oral bacteria. PMID:24438035

  16. Antidiabetic effect of an aqueous extract of Pomegranate (Punica granatum L. peels in normal and alloxan diabetic rats

    Enas A. M. Khalil

    2004-09-01

    Full Text Available Hypoglycaemic drugs are either too expensive or have undesirable side effects including hematological, coma and disturbances of liver and kidney. Limiting of diabetes without any side effects is still a challenge to the medical system. This leads to exert effort to search for effective, safer and less cost antidiabetic plants. This investigation aims to evaluate the role of Punica granatum powder peels extract in its human therapeutic dose on beta cell numbers blood glucose and plasma insulin levels in normal and alloxan diabetic rats for 4-weeks of treatment. The treatment revealed that pomegranate aqueous extract significant decreased blood glucose and increased insulin levels in normal and diabetic treated rats. Pancreas showed increased number of beta cells in normal and treated diabetic rats. In conclusion pomegranate peel aqueous extract can reduce blood sugar through regeneration of ß cells.

  17. Influence of Punica granatum L. on region specific responses in rat brain during Alloxan-Induced diabetes

    Sushil Kumar Middha; Talambedu Usha; Tekupalli RaviKiran

    2012-01-01

    Objective: The present study was carried out to investigate the effects of Punica granatum peel methanolic extract (PGPE) on cerebral cortex (CC) and Hippocampus (HC) brain antioxidant defense system and markers of lipid and protein oxidation in alloxan induced diabetic rats.Methods:Oral administration of PGPE (75 and 150 mg of kg body weight) for 45 days resulted in significant reduction in blood glucose levels. Results: Supplementation of diabetic rats with PGPE showed increased activities of SOD and GPx with concomitant decrease in MDA and PC content. Region-specific changes were more evident in the HC when compared to CC. Conclusions: The present study indicated that PGPE can ameliorate brain oxidative stress in alloxan induced diabetic rats by up regulating antioxidant defense mechanism by attenuating lipid and protein oxidation. PGPE thus may be used as a potential therapeutic agent in preventing diabetic complications in the brain.

  18. The Investigation for Antifungal Effect of Medicinal Plants, Combination Infusion of Piper Bettle Leaves, Punica Granatum Fructus Cortec, Curcuma Domestica Rhizome

    Berna Elya

    2002-12-01

    Full Text Available The tested demartophyta used Candida albicans. This research using dilution method to determine of minimum inhibitory concentration (MIC and difusion method to determine zone inhibition around of disc. The results of determination of MIC showed that combination infusion Piper bettle leaves with Punica granatum Fructus Cortex against C. albicans respectively, 31,2 mg/ml : 7,8 mg/ml; 15,6 mg/ml : 15,6 mg/ml and 7,8 mg/ml : 31,2 mg/ml. The determination for zone inhibition from 3 concentration of infusion of Piper bettle leaves with 3 concentration of Punica granatum Fructus Cortex with 9 combination against C. albicans showed that combination of two infusion is the larger than the single infusion.

  19. Inhibitory Effect of the Punica granatum Fruit Extract on Angiotensin-II Type I Receptor and Thromboxane B2 in Endothelial Cells Induced by Plasma from Preeclamptic Patients

    Widya Kusumawati; Kusnarman Keman; Setyawati Soeharto

    2016-01-01

    This study aims to evaluate whether the Punica granatum fruit extract modulates the Angiotensin-II Type I receptor (AT1-R) and thromboxane B2 level in endothelial cells induced by plasma from preeclamptic patients. Endothelial cells were obtained from human umbilical vascular endothelial cells. At confluence, endothelial cells were divided into five groups, which included endothelial cells exposed to 2% plasma from normal pregnancy (NP), endothelial cells exposed to 2% plasma from preeclampti...

  20. Parasiticidal and brine shrimp cytotoxicity potential of crude methanolic extract of rind of Punica granatum Linn against round worms and tape worms.

    Ali, Niaz; Jamil, Ayesha; Shah, Syed Wadood Ali; Shah, Ismail; Ahmed, Ghayour; Junaid, Muhammad; Ahmed, Zahoor

    2015-05-01

    Rind of Punica granatum is traditionally used for anthelmintic purposes. The current work describes the possible anthelmintic activity of crude methanolic extract of Punica granatum (Pg. Cr) against round worms (Ascaridia galli) and the tape worms (Raillietina spiralis). Brine shrimp cytotoxicity is also performed. Brine shrimp cytotoxic activity was tested using different concentrations (1000 μg/mL, 100 μg/mL and 10 μg/mL) of Pg.Cr. In vitro anthelmintic activity of Pg. Cr was determined against the parasites using albendazole and piperazine citrate as standard anthelmintic drugs in concentration 10 mg/ml. LC50 value for Brine shrimp cytotoxicity was 189.44 ±28 μg/mL. In test concentration of 40mg/ml of the Pg. Cr, Raillietina spiralis was paralyzed in 23 minutes. However, for parasiticidal activity (death of the parasite), it took less time (40 minutes) as compared to standard Albendazole. Time taken for death of the parasite Raillietina spiralis, in concentration 40 mg /ml, is 40 min. While standard drugs took more time to kill the Raillietina spiralis. Pg. Cr took 19 minutes to paralyze the Ascaridia galli at concentration 40 mg/ml whereas; it took 48 minutes for to kill the parasite Ascaridia galli. The current work confirms the traditional use of rind of Punica granatum as anthelmintic against Raillietina spiralis and Ascaridia galli. Results of brine shrimp cytotoxicity assay warrant for the isolation of cytotoxic compounds. List of abbreviation- Pg. Cr = Crude methanolic extract of Punica granatum. PMID:26004729

  1. Antifungal activity of the ethanolic extracts of Punica granatum L. and evaluation of the morphological and structural modifications of its compounds upon the cells of Candida spp.

    Paula Cristina Anibal; Iza Teixeira Alves Peixoto; Mary Ann Foglio; José Francisco Höfling

    2013-01-01

    Ethanolic crude extracts prepared from the arils and seeds, pericarp, peels and from the whole fruit of Punica granatum, known as pomegranate, had their antifungal activity tested against Candida spp. The ethanolic crude extracts were analyzed by Mass Spectrometry and yielded many compounds such as punicalagin and galladydilacton. The extracts from the pericarp and peel showed activity against Candida spp., with MICs of 125 μg/mL. The effect of pericarp and peel extracts upon the morphologica...

  2. Protective Effects of Combined Selenium and Punica granatum Treatment on Some Inflammatory and Oxidative Stress Markers in Arsenic-Induced Hepatotoxicity in Rats.

    Shafik, Noha M; El Batsh, Maha M

    2016-01-01

    Oxidative stress is one of the major mechanisms implicated in inorganic arsenic poisoning. Punica granatum is known by its free radical scavenging properties. The aim of this study was to evaluate the protective role of combined selenium and P. granatum against arsenic-induced liver injury. Seventy-five female albino rats were divided into five groups (of 15 rats each). Toxicity was induced by oral sodium arsenite (5.5 mg/kg body weight (bw) daily) (group ІІ). Treatment of arsenic-intoxicated rats was induced by daily oral administration of sodium selenite (3 mg/kg bw) (group ІІІ), 100 mg of P. granatum ethanol extract per kilogram body weight dissolved in 300 mL distilled water in three divided doses (100 mL of this suspension every 8 h) (group IV), and combined daily oral treatment with both selenite and P. granatum ethanol extract (group V). After 3 weeks, serum and liver tissues were obtained from the decapitated rats for different estimations. Hepatotoxicity was demonstrated by significant elevation in liver weights and activities of liver enzymes, alanine aminotransferase (ALT) and aspartate aminotransferase (AST), and decrease in serum total proteins and albumin (p granatum and selenium. It was concluded that combined P. granatum and selenium treatment had a synergistic hepatoprotective effect against arsenic toxicity through activation of Nrf2 anti-oxidant pathway. PMID:26085057

  3. Two UGT84 Family Glycosyltransferases Catalyze a Critical Reaction of Hydrolyzable Tannin Biosynthesis in Pomegranate (Punica granatum)

    Ono, Nadia N.; Qin, Xiaoqiong; Wilson, Alexander E.; Li, Gang

    2016-01-01

    Hydrolyzable tannins (HTs) play important roles in plant herbivore deterrence and promotion of human health. A critical step in HT production is the formation of 1-O-galloyl-β-D-glucopyranoside (β-glucogallin, ester-linked gallic acid and glucose) by a UDP-glucosyltransferase (UGT) activity. We cloned and biochemically characterized four candidate UGTs from pomegranate (Punica granatum), of which only UGT84A23 and UGT84A24 exhibited β-glucogallin forming activities in enzyme assays. Although overexpression and single RNAi knockdown pomegranate hairy root lines of UGT84A23 or UGT84A24 did not lead to obvious alterations in punicalagin (the prevalent HT in pomegranate) accumulation, double knockdown lines of the two UGTs resulted in largely reduced levels of punicalagins and bis-hexahydroxydiphenyl glucose isomers. An unexpected accumulation of galloyl glucosides (ether-linked gallic acid and glucose) was also detected in the double knockdown lines, suggesting that gallic acid was utilized by an unidentified UGT activity for glucoside formation. Transient expression in Nicotiana benthamiana leaves and immunogold labeling in roots of pomegranate seedlings collectively indicated cytosolic localization of UGT84A23 and UGT84A24. Overall, functional characterization and localization of UGT84A23 and UGT84A24 open up opportunities for further understanding the regulatory control of HT metabolism in plants and its coordination with other biochemical pathways in the metabolic network. PMID:27227328

  4. Two UGT84 Family Glycosyltransferases Catalyze a Critical Reaction of Hydrolyzable Tannin Biosynthesis in Pomegranate (Punica granatum.

    Nadia N Ono

    Full Text Available Hydrolyzable tannins (HTs play important roles in plant herbivore deterrence and promotion of human health. A critical step in HT production is the formation of 1-O-galloyl-β-D-glucopyranoside (β-glucogallin, ester-linked gallic acid and glucose by a UDP-glucosyltransferase (UGT activity. We cloned and biochemically characterized four candidate UGTs from pomegranate (Punica granatum, of which only UGT84A23 and UGT84A24 exhibited β-glucogallin forming activities in enzyme assays. Although overexpression and single RNAi knockdown pomegranate hairy root lines of UGT84A23 or UGT84A24 did not lead to obvious alterations in punicalagin (the prevalent HT in pomegranate accumulation, double knockdown lines of the two UGTs resulted in largely reduced levels of punicalagins and bis-hexahydroxydiphenyl glucose isomers. An unexpected accumulation of galloyl glucosides (ether-linked gallic acid and glucose was also detected in the double knockdown lines, suggesting that gallic acid was utilized by an unidentified UGT activity for glucoside formation. Transient expression in Nicotiana benthamiana leaves and immunogold labeling in roots of pomegranate seedlings collectively indicated cytosolic localization of UGT84A23 and UGT84A24. Overall, functional characterization and localization of UGT84A23 and UGT84A24 open up opportunities for further understanding the regulatory control of HT metabolism in plants and its coordination with other biochemical pathways in the metabolic network.

  5. Prophylactic effects of pomegranate (Punica granatum) juice on sodium fluoride induced oxidative damage in liver and erythrocytes of rats.

    Bouasla, Asma; Bouasla, Ihcène; Boumendjel, Amel; Abdennour, Cherif; El Feki, Abdelfattah; Messarah, Mahfoud

    2016-07-01

    The objective of this study was to investigate the protective effects of pomegranate (Punica granatum) juice (PGJ) on oxidative damages in liver tissue and erythrocytes of rats intoxicated by sodium fluoride (NaF). Rats were randomly divided into two groups: group I received standard diet and group II received orally 1 mL of PGJ. After 5 weeks of pretreatment, each group was divided again into two subgroups and treated for another 3 weeks as follows: group I was subdivided into a control group and a group that was treated with 100 ppm of NaF (in drinking water); group II was subdivided into one group that was treated daily with both 100 ppm NaF and PGJ (1 mL orally) and one that received daily 1 mL of pomegranate juice. Exposure to NaF decreased hematological parameters, changed the total protein, albumin, bilirubin levels, and increased the activities of hepatic marker enzymes. We also noted an increase in lipid peroxidation contents, accompanied by a decrease of reduced glutathione levels. Antioxidant enzyme activities in both tissues were modified in the NaF group compared with the control group. However, the administration of PGJ juice caused an amelioration of the previous parameters. Our results indicated the potential effects of NaF to induce oxidative damage in tissues and the ability of PGJ to attenuate NaF-induced oxidative injury. PMID:27124270

  6. The Effectiveness of Cinnamomum zeylanicum, Punica granatum Flower and Capsicum annuum Extracts Against Parascaris equorum Infective Larvae

    Ehsan RAKHSHANDEHROO

    2016-07-01

    Full Text Available Recent investigations have shown that plants with medicinal peculiarities as good alternative to anthelmintics for livestock. In this study, the anthelmintic effects of three medicinal herbs (Cinnamomum zeylanicum, Punica granatum flower and Capsicum annuum were screened in vitro against the infective larvae of Parascaris equorum. The recovered larvae of the parasite were exposed to four concentrations (50, 75, 100 and 125 mg/mL of the extracts and then they examined for the viability at 0, 10, 20, 30 and 40 minutes after the challenge. The results revealed that all the concentrations of each plant extract had anthelmintic effects on P. equorum larvae. Also, the statistics indicated that there were significant interactions between the concentration of the extracts and time of exposure on the number of viable larvae. In addition, C. annuum extract seemed to be a strong potency to kill larvae at all concentrations from the beginning of the experiment. These results confirmed that those herbal extracts possess good antiparasitic effects against infective larvae of P. equorum and thus could be considered in anthelminth treatment strategies.

  7. Antidiabetic effect of Punica granatum flowers: effect on hyperlipidemia, pancreatic cells lipid peroxidation and antioxidant enzymes in experimental diabetes.

    Bagri, Priyanka; Ali, Mohd; Aeri, Vidhu; Bhowmik, Malay; Sultana, Shahnaz

    2009-01-01

    The present study investigated the effects of Punica granatum aqueous extract (PgAq) on streptozotocin (STZ) induced diabetic rats by measuring fasting blood glucose, lipid profiles (atherogenic index), lipid peroxidation (LPO) and activities of both non-enzymatic and enzymatic antioxidants. Diabetes was induced by single intraperitoneal injection of STZ (60 mg/kg) to albino Wistar rats. The increase in blood glucose level, total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), very low density lipoprotein (VLDL), LPO level with decrease in high density lipoprotein cholesterol (HDL-C), reduced glutathione (GSH) content and antioxidant enzymes namely, glutathione peroxidase (GPx), glutathione reductase (GR), glutathione-S-transferase (GST), superoxide dismutase (SOD) and catalase (CAT) were the salient features observed in diabetic rats. On the other hand, oral administration of PgAq at doses of 250 mg/kg and 500 mg/kg for 21 days resulted in a significant reduction in fasting blood glucose, TC, TG, LDL-C, VLDL-C and tissue LPO levels coupled with elevation of HDL-C, GSH content and antioxidant enzymes in comparison with diabetic control group. The results suggest that PG could be used, as a dietary supplement, in the treatment of chronic diseases characterized by atherogenous lipoprotein profile, aggravated antioxidant status and impaired glucose metabolism and also in their prevention. PMID:18950673

  8. Punica granatum flower extract, a potent alpha-glucosidase inhibitor, improves postprandial hyperglycemia in Zucker diabetic fatty rats.

    Li, Yuhao; Wen, Suping; Kota, Bhavani Prasad; Peng, Gang; Li, George Qian; Yamahara, Johji; Roufogalis, Basil D

    2005-06-01

    Postprandial hyperglycemia plays an important role in the development of type 2 diabetes and has been proposed as an independent risk factor for cardiovascular diseases. The flowering part of Punica granatum Linn. (Punicaceae) (PGF) has been recommended in Unani literature as a remedy for diabetes. We investigated the effect and action mechanism of a methanolic extract from PGF on hyperglycemia in vivo and in vitro. Oral administration of PGF extract markedly lowered plasma glucose levels in non-fasted Zucker diabetic fatty rats (a genetic model of obesity and type 2 diabetes), whereas it had little effect in the fasted animals, suggesting it affected postprandial hyperglycemia in type 2 diabetes. In support of this conclusion the extract was found to markedly inhibit the increase of plasma glucose levels after sucrose loading, but not after glucose loading in mice, and it had no effect on glucose levels in normal mice. In vitro, PGF extract demonstrated a potent inhibitory effect on alpha-glucosidase activity (IC50: 1.8 microg/ml). The inhibition is dependent on the concentration of enzyme and substrate, as well as on the length of pretreatment with the enzyme. These findings strongly suggest that PGF extract improves postprandial hyperglycemia in type 2 diabetes and obesity, at least in part, by inhibiting intestinal alpha-glucosidase activity. PMID:15894133

  9. Amelioration of Diabetes and Painful Diabetic Neuropathy by Punica granatum L. Extract and Its Spray Dried Biopolymeric Dispersions

    K. Raafat

    2014-01-01

    Full Text Available Aims. To evaluate the effect of Punica granatum (Pg rind extract and its spray dried biopolymeric dispersions with casein (F1 or chitosan (F2 against Diabetes mellitus (DM and diabetic neuropathy (DN. Methods. We measured the acute (6 h and subacute (8 days effect of various doses of Pg, F1, and F2 and the active compounds on alloxan-induced DM mouse model. We evaluated DN utilizing latency tests for longer period of time (8 weeks. In addition, the in vivo antioxidant activity was assessed utilizing serum catalase level. Results. The results proved that the highest dose levels of Pg extract, F1, F2 exerted remarkable hypoglycemic activity with 48, 52, and 40% drop in the mice glucose levels after 6 hours, respectively. The tested compounds also improved peripheral nerve function as observed from the latency tests. Bioguided fractionation suggested that gallic acid (GA was Pg main active ingredient responsible for its actions. Conclusion. Pg extract, F1, F2, and GA could be considered as a new therapeutic potential for the amelioration of diabetic neuropathic pain and the observed in vivo antioxidant potential may be involved in its antinociceptive effect. It is highly significant to pay attention to Pg and GA for amelioration and control of DM and its complications.

  10. Two UGT84 Family Glycosyltransferases Catalyze a Critical Reaction of Hydrolyzable Tannin Biosynthesis in Pomegranate (Punica granatum).

    Ono, Nadia N; Qin, Xiaoqiong; Wilson, Alexander E; Li, Gang; Tian, Li

    2016-01-01

    Hydrolyzable tannins (HTs) play important roles in plant herbivore deterrence and promotion of human health. A critical step in HT production is the formation of 1-O-galloyl-β-D-glucopyranoside (β-glucogallin, ester-linked gallic acid and glucose) by a UDP-glucosyltransferase (UGT) activity. We cloned and biochemically characterized four candidate UGTs from pomegranate (Punica granatum), of which only UGT84A23 and UGT84A24 exhibited β-glucogallin forming activities in enzyme assays. Although overexpression and single RNAi knockdown pomegranate hairy root lines of UGT84A23 or UGT84A24 did not lead to obvious alterations in punicalagin (the prevalent HT in pomegranate) accumulation, double knockdown lines of the two UGTs resulted in largely reduced levels of punicalagins and bis-hexahydroxydiphenyl glucose isomers. An unexpected accumulation of galloyl glucosides (ether-linked gallic acid and glucose) was also detected in the double knockdown lines, suggesting that gallic acid was utilized by an unidentified UGT activity for glucoside formation. Transient expression in Nicotiana benthamiana leaves and immunogold labeling in roots of pomegranate seedlings collectively indicated cytosolic localization of UGT84A23 and UGT84A24. Overall, functional characterization and localization of UGT84A23 and UGT84A24 open up opportunities for further understanding the regulatory control of HT metabolism in plants and its coordination with other biochemical pathways in the metabolic network. PMID:27227328

  11. Rapid and Comprehensive Evaluation of (Polyphenolic Compounds in Pomegranate (Punica granatum L. Juice by UHPLC-MSn

    Daniele Del Rio

    2012-12-01

    Full Text Available The comprehensive identification of phenolic compounds in food and beverages is a crucial starting point for assessing their biological, nutritional, and technological properties. Pomegranate (Punica granatum L. has been described as a rich source of (polyphenolic components, with a broad array of different structures (phenolic acids, flavonoids, and hydrolyzable tannins and a quick, high throughput, and accurate screening of its complete profile is still lacking. In the present work, a method for UHPLC separation and linear ion trap mass spectrometric (MSn characterization of pomegranate juice phenolic fraction was optimized by comparing several different analytical conditions. The best solutions for phenolic acids, anthocyanins, flavonoids, and ellagitannins have been delineated and more than 70 compounds have been identified and fully characterized in less than one hour total analysis time. Twenty-one compounds were tentatively detected for the first time in pomegranate juice. The proposed fingerprinting approach could be easily translated to other plant derived food extracts and beverages containing a wide array of phytochemical compounds.

  12. Purification and Antioxidant Activity of Polyphenols from Punica granatum L.%石榴叶多酚的纯化及抗氧化活性研究

    邢佳; 陆文娟; 赵云霞; 陶明煊

    2015-01-01

    采用大孔树脂对石榴叶粗多酚进行纯化,得到3种不同纯度的石榴叶多酚,对这3种多酚的抗氧化活性进行研究并与芦丁对比.结果显示,最佳纯化工艺条件为:上柱质量浓度2.5 mg/mL,pH=4,上柱速率2 mL/min,乙醇体积分数60%,洗脱量为1.7 BV~2.0 BV.经AB-8大孔树脂分离后,石榴叶多酚的纯度提高到62.44%,再经聚酰胺树脂分离后石榴叶多酚的纯度为92.83%.石榴叶多酚的抗氧化性研究结果表明,3种不同纯度的多酚均具有清除自由基的效果及还原能力,而且纯度越高清除自由基的效果越好,还原能力越强.与芦丁相比,纯化后的石榴叶多酚具有更好的还原力及清除亚硝酸盐的能力.%The macroporous resin was choosen for separating crude polyphenols from the leaves of Punica granatum L., three different purity of polyphenols from Punica granatum L. leaves were got,compared with Rutin,three different puri⁃ty of polyphenols from Punica granatum L. were evaluated with different antioxidant tests. The results showed that with sample solution concentration of 2.5 mg/mL,pH=4,feeding speed of 2 mL/min,ethanol concentration of 60%,elution volume of 1.7 BV~2.0 BV,the purity of CPPL was 62.44%,the purity of purified polyphenols of crude polyphenols from Punica granatum L. leaves was 92.83%which was further improved by PA. The results of oxidation stability analysis of polyphenols in Punica granatum L. leaves were showed that it had the better effect in scavenging free radical and reduc⁃ing power with the higher purity,compared with rutin,reducing power and nitrite scavenging activity of purified polyphe⁃nols from Punica granatum L. leaves was stronger.

  13. Pharmacological investigations of Punica granatum in glycerol-induced acute renal failure in rats

    Amrit Pal Singh; Amteshwar Jaggi Singh; Nirmal Singh

    2011-01-01

    Objective : The present study was designed to investigate the ameliorative potential and possible mechanism of hydroalcoholic extract of flowers of P. granatum in glycerol-induced acute renal failure (ARF) in rats. Materials and Methods : The rats were subjected to rhabdomyolytic ARF by single intramuscular injection of hypertonic glycerol (50% v/v; 8 ml/kg) and the animals were sacrificed after 24 hours of glycerol injection. The plasma creatinine, blood urea nitrogen, creatinine clearance, ...

  14. Ellagitannins of the fruit rind of pomegranate (Punica granatum antagonize in vitro the host inflammatory response mechanisms involved in the onset of malaria

    Bhattacharya Deepak

    2010-07-01

    Full Text Available Abstract Background The sun-dried rind of the immature fruit of pomegranate (Punica granatum is presently used as a herbal formulation (OMARIA, Orissa Malaria Research Indigenous Attempt in Orissa, India, for the therapy and prophylaxis of malaria. The pathogenesis of cerebral malaria, a complication of the infection by Plasmodium falciparum, is an inflammatory cytokine-driven disease associated to an up-regulation and activity of metalloproteinase-9 and to the increase of TNF production. The in vitro anti-plasmodial activity of Punica granatum (Pg was recently described. The aim of the present study was to explore whether the anti-malarial effect of OMARIA could also be sustained via other mechanisms among those associated to the host immune response. Methods From the methanolic extract of the fruit rind, a fraction enriched in tannins (Pg-FET was prepared. MMP-9 secretion and expression were evaluated in THP-1 cells stimulated with haemozoin or TNF. The assays were conducted in the presence of the Pg-FET and its chemical constituents ellagic acid and punicalagin. The effect of urolithins, the ellagitannin metabolites formed by human intestinal microflora, was also investigated. Results Pg-FET and its constituents inhibited the secretion of MMP-9 induced by haemozoin or TNF. The effect occurred at transcriptional level since MMP-9 mRNA levels were lower in the presence of the tested compounds. Urolithins as well inhibited MMP-9 secretion and expression. Pg-FET and pure compounds also inhibited MMP-9 promoter activity and NF-kB-driven transcription. Conclusions The beneficial effect of the fruit rind of Punica granatum for the treatment of malarial disease may be attributed to the anti-parasitic activity and the inhibition of the pro-inflammatory mechanisms involved in the onset of cerebral malaria.

  15. Comparing the Extraction Methods of Punica granatum Seed Oil%石榴种籽油提取方法的比较

    杨万政; 路静; 杜晓鸣; 汪丽萍

    2011-01-01

    Objective To optimize the extracting technology of seed oil from Punica Granatum. Methods 4 methods: Supercritical CO2, ultrasonic wave, microwave and solvent reflux were used to extract Punica granatum seed oil. Extraction results were compared to determine the optimal method. Results Supercritical CO2 proved to be the best method. The optimal condition was as follows: extraction press, 30 Mpa; separation press, 10 Mpa; extraction temperature, 50℃; separation temperature, 40 ℃. And extraction time, 2 h. The extraction rate was above 17%. Conclusion Analysis of oil content and fat acids constitution in the seeds shows the fat acid in Punica granatum seeds consist mainly of C18 punicic acid.%目的 研究提取石榴籽油的最佳工艺.方法 采用超临界CO2流体萃取、超声波萃取、微波萃取、溶剂回流萃取四种方法提取石榴种籽中的油脂.结果 确定最佳条件为:超临界CO2流体萃取,当萃取压力30 Mpa,分离压力:10Mpa,萃取温度:50℃,分离温度:40℃,提取2h,提取率可达17%以上.结论 通过对种籽中油脂含量及脂肪酸组成的分析,石榴的脂肪酸主要由C18的石榴酸组成.

  16. Study of nutrient composition in pollen of Punica granatum L.%安石榴花粉产量及营养成分

    张秀春

    2001-01-01

    The authors report the yield and nutrient composition of pollen which were yielded by Punica granatum L. The results show that not only the plant's is rich, but also its nutrient composition is rich Its value of explotation and utitilization is very well.%对安石榴的产量及蛋白质、氨基酸等营养成分进行了分析测定;结果表明安石榴花粉资源丰富,营养成分齐全,具有很好的开发利用价值。

  17. The Investigation for Antifungal Effect of Medicinal Plants, Combination Infusion of Piper Bettle Leaves, Punica Granatum Fructus Cortec, Curcuma Domestica Rhizome

    Berna Elya; Atiek Soemiati

    2002-01-01

    The tested demartophyta used Candida albicans. This research using dilution method to determine of minimum inhibitory concentration (MIC) and difusion method to determine zone inhibition around of disc. The results of determination of MIC showed that combination infusion Piper bettle leaves with Punica granatum Fructus Cortex against C. albicans respectively, 31,2 mg/ml : 7,8 mg/ml; 15,6 mg/ml : 15,6 mg/ml and 7,8 mg/ml : 31,2 mg/ml. The determination for zone inhibition from 3 concentration ...

  18. Potential Anti-Inflammatory Effects of the Hydrophilic Fraction of Pomegranate (Punica granatum L.) Seed Oil on Breast Cancer Cell Lines

    Susan Costantini; Fabiola Rusolo; Valentina De Vito; Stefania Moccia; Gianluca Picariello; Francesca Capone; Eliana Guerriero; Giuseppe Castello; Maria Grazia Volpe

    2014-01-01

    In this work, we characterized conjugated linolenic acids (e.g., punicic acid) as the major components of the hydrophilic fraction (80% aqueous methanol extract) from pomegranate (Punica granatum L.) seed oil (PSO) and evaluated their anti-inflammatory potential on some human colon (HT29 and HCT116), liver (HepG2 and Huh7), breast (MCF-7 and MDA-MB-231) and prostate (DU145) cancer lines. Our results demonstrated that punicic acid and its congeners induce a significant decrease of cell viabili...

  19. Germinação de sementes de romäzeiras (Punica granatum L.) de acordo com a concentração de giberelina

    William Takata; Ewerton Gasparetto da Silva; Jaqueline Malagutti Corsato; Gisela Ferreira

    2014-01-01

    A romäzeira (Punica granatum L.) é fruteira de porte arbustivo, utilizada geralmente como planta ornamental e explorada quanto a suas características medicinais. Seus frutos apresentam cavidades internas onde estäo alojadas numerosas sementes e sem a presença de endosperma. Estas sementes apresentam certa dificuldade para germinar, sendo que se conseguiu atingir porcentagens satisfatórias de germinação com a utilização de estratificação, que é processo necessário para a quebra da dormência fi...

  20. Caracteres morfoanatómicos de diferentes cortezas de la medicina folklórica argentina : II. Punica granatum L. (Punicaceae) y su adulterante Buxus sempervirens L. (Buxaceae)

    Di Sapio Osvaldo Antonio; Gattuso, Martha

    1994-01-01

    Se presenta un estudio comparativo, morfoanatómico e histoquímico, de la corteza de raíz y tailo de Punica granatum L. (Punicaceae), "corteza de granado" -utilizada en medicina popular por sus propiedades tenífugas y antiheimínticas- y de su adulterante, Buxus sempervirens L. (Buxaceae), "boj". El análisis efectuado posibilita la confección de un cuadro de caracteres con valor diagnóstico. Estos permiten la identificación de las citadas especies al estado de droga entera o fragmentada.

  1. High-yielding Horticultural Technique for Punica granatum%蒙自石榴丰产栽培技术研究

    李品荣; 陈强; 常恩福; 周洪昌; 王锡全; 李红兵; 李玉文; 刘永国; 徐珑峰

    2001-01-01

    @@ 蒙自石榴(Punica granatum)早实丰产,是山区群众脱贫致富的最佳经济林树种之一.本研究通过对蒙自石榴的丰产栽培技术措施进行田间试验,寻找较佳的技术组合,为滇东南岩溶山区的经济发展提供技术支撑. 1试验地概况及方法 1.1试验地概况

  2. 濒危品种软籽石榴的组织培养和快速繁殖%Tissue Culture and Rapid Propagation of Punica granatum

    闫志佩

    2004-01-01

    1植物名称 石榴(Punica granatum)。2材料类别 新梢茎尖。3培养条件 (1)芽诱导培养基:MS+6.BA1.5mg·L-1(单位下同)+IBA0.2+NAA0.1;(2)芽增殖培养基:MS+6-BA2.0+IBA0.5;(3)生根培养基:

  3. Mikrobna proizvodnja antioksidativnih dodataka hrani na čvrstoj podlozi od kore šipka (Punica granatum) i lišća grma Larrea tridentata

    Aguilar, Cristóbal Noé; Aguilera-Carbo, Antonio; Robledo, Armando; Ventura, Janeth; Belmares, Ruth; Martinez, Diego; Rodríguez-Herrera, Raul; Contreras, Juan

    2008-01-01

    U radu je istražena mogućnost primjene lišća grma Larrea tridentata i kore šipka (Punica granatum) kao sirovina za dodatak čvrstim podlogama te proizvodnju antioksidanasa. U središtu je istraživanja kinetička procjena fizikalno-kemijskih promjena tih taninima bogatih sirovina, ističući promjenu udjela polifenolnih spojeva tijekom procesa. Za proces je upotrijebljen soj plijesni Aspergillus niger GH1, koji je praćen tijekom 96 sati. Određen je udio proteina, sirovih vlakana, lipida, te ukupnih...

  4. Research progress on pharmacological activities of flowers ofPunica granatum%石榴花的药理作用研究进展

    赵永昕; 热娜·卡斯木

    2015-01-01

    Punica granatum L. has a long medicinal usage history, and the different parts ofP. granatum are very popular in traditional Chinese medicine and other ethnic medicine. In recent years, the pharmacological research of flowers ofP. granatum on antioxidation, hypoglycemic action, and hypolipidemic effect have proceeded rapidly. The scientific collection and analysis on effects and new pharmacological research results of flowers ofP. granatum are reviewed, in order to provide theoretical foundation for the comprehensive development and utilization of resource.%石榴药用历史悠久,不同部位在中医药与民族医药中应用广泛。近年来,有关石榴花的抗氧化、降血糖及调血脂等药理研究进展迅速,通过整理归纳并科学的分析石榴花的功效及其新的药理学研究成果,以期为石榴花的进一步研究和资源的合理利用提供理论依据。

  5. Avaliação da atividade antioxidante em diferentes extratos da polpa e sementes da romã (Punica granatum, L. Antioxidant activity evaluation of different polarities extracts by pulp and seeds of pomegranate (Punica granatum, L.

    Fernanda Archilla Jardini

    2007-03-01

    Full Text Available Avaliou-se a atividade antioxidante dos extratos etéreo, alcoólico e aquoso obtidos da polpa e das sementes da romã (Punica granatum, L., utilizando-se dois sistemas: 1 co-oxidação do beta-caroteno/ácido linoléico e 2 Rancimat®. Inicialmente foram determinados os compostos redutores presentes na polpa (1.214 mg/100 g e nas sementes (1.732 mg/100 g e, em seqüência, avaliou-se nos extratos, através de cromatografia em camada delgada (CCD, a presença de compostos fenólicos com atividade antioxidante. Os extratos aquosos tanto da polpa quanto das sementes apresentaram as maiores porcentagens de inibição da oxidação: 87,31% e 93,08%, respectivamente. Através da avaliação cinética pelo teste de co-oxidação com beta-caroteno e ácido linoléico, pôde-se verificar que a alta porcentagem da atividade antioxidante dos extratos aquosos é devida à capacidade de inibir a oxidação nas fases inicial e mais avançada do processo oxidativo, agindo por mecanismos primário e secundário. Todos os extratos (etéreo, alcoólico e aquoso apresentaram elevada capacidade em prolongar o período de indução da oxidação, medida pelo aparelho Rancimat®, sendo, ainda, significativamente (pIn etheric, alcoholic and aqueous extracts obtained from pomegranate (Punica granatum, L. pulp and seeds their antioxidant activity was evaluated by using two systems: co-oxidation of beta-carotene/linoleic acid and 2 Rancimat®. First of all, the presence of reducing compounds was detected in the pulp (1,214 mg/100 g and in the seeds (1,732 mg/100 g. The phenolic compounds with antioxidant activity were then evaluated in the extracts using thin-layer chromatography (TLC. The aqueous extracts from the pulp and the seeds showed the highest antioxidant activity of 87.31% and of 93.08%, respectively. The kinetic curves obtained by cooxidation of beta-carotene and linoleic acid substrates also showed the highest values in the aqueous. These results were

  6. Protective effects of Punica Granatum (L) and synthetic ellagic acid on radiation induced biochemical alterations in Swiss albino mice

    Ionizing radiations produce deleterious effects in the living organisms and the rapid technological advancement has increased human exposure to ionizing radiations enormously. Radiotherapy, which is a chief modality to treat cancer, faces a major drawback because it produces severe side effects developed due to damage to normal tissue by reactive oxygen species (ROS). Recent studies have indicated that some commonly used medicinal plants may be good sources of potent but non-toxic radioprotectors. The pomegranate, Punica granatum L., an ancient, mystical, and highly distinctive fruit, is the predominant member of the Punicaceae family. It is used in several systems of medicine for a variety of ailments. The objective of the present study was to investigate the protective effects of ethanolic extracts of pomegranate whole fruit (EPWF) and seeds (EPS) and Synthetic Ellagic acid (EA) against Electron beam radiation(EBR) induced biochemical alterations in Swiss albino mice. The extracts and synthetic compound were assessed for its radical scavenging property by DPPH radical scavenging and Ferric Reducing Antioxidant Power assays. The animals were exposed to sub-lethal dose (6 Gy) of Electron Beam Radiation and then treated with 200 mg/kg body wt. of pomegranate extracts and synthetic ellagic acid for 15 consecutive days. The biochemical estimations were carried out in the liver homogenate of the sacrificed animals. Radiation induced depletion in the level of reduced glutathione and total antioxidant capacity were prevented significantly by EPWF, EPS and EA administration. Also there was significant reduction in the levels of membrane lipid peroxidation in the treated groups compared to irradiated control. The findings of our study indicate the protective efficacy of pomegranate extracts and synthetic ellagic acid on radiation induced biochemical changes in mice may be due to its free radical scavenging and increased antioxidant levels. (author)

  7. Anti-diabetic action of Punica granatum flower extract: activation of PPAR-gamma and identification of an active component.

    Huang, Tom H W; Peng, Gang; Kota, Bhavani P; Li, George Q; Yamahara, Johji; Roufogalis, Basil D; Li, Yuhao

    2005-09-01

    Peroxisome proliferator-activated receptor (PPAR)-gamma activators are widely used in the treatment of type 2 diabetes because they improve the sensitivity of insulin receptors. Punica granatum flower (PGF) has been used as an anti-diabetic medicine in Unani medicinal literature. The mechanism of actions is, however, unknown. In the current study, we demonstrated that 6-week oral administration of methanol extract from PGF (500 mg/kg, daily) inhibited glucose loading-induced increase of plasma glucose levels in Zucker diabetic fatty rats (ZDF), a genetic animal model for type 2 diabetes, whereas it did not inhibit the increase in Zucker lean rats (ZL). The treatment did not lower the plasma glucose levels in fasted ZDF and ZL rats. Furthermore, RT-PCR results demonstrated that the PGF extract treatment in ZDF rats enhanced cardiac PPAR-gamma mRNA expression and restored the down-regulated cardiac glucose transporter (GLUT)-4 (the insulin-dependent isoform of GLUTs) mRNA. These results suggest that the anti-diabetic activity of PGF extract may result from improved sensitivity of the insulin receptor. From the in vitro studies, we demonstrated that the PGF extract enhanced PPAR-gamma mRNA and protein expression and increased PPAR-gamma-dependent mRNA expression and activity of lipoprotein lipase in human THP-1-differentiated macrophage cells. Phytochemical investigation demonstrated that gallic acid in PGF extract is mostly responsible for this activity. Thus, our findings indicate that PPAR-gamma is a molecular target for PGF extract and its prominent component gallic acid, and provide a better understanding of the potential mechanism of the anti-diabetic action of PGF. PMID:16102567

  8. Un extracto de Punica granatum L. (BLBu sobre la apoptosis inducida por virus influenza A y B

    Isis Casadelvalle Pérez

    2006-01-01

    Full Text Available La apoptosis ha sido ampliamente reconocida como un mecanismo intrínseco de autodestrucción en las células animales. Este fenómeno puede ser inducido por múltiples factores, entre los que se pueden citar algunos virus, que lo utilizan como vía de diseminación en el hospedero. Para contrarrestar este mecanismo se han usado extractos obtenidos de plantas con propiedades antivirales, los cuales, intuitivamente, pudieran ejercer su efecto sobre la apoptosis inducida por los virus. En el presente trabajo se estudió el efecto de un extracto natural de Punica granatum L. sobre la apoptosis inducida por dos virus: influenza A e influenza B en dos líneas celulares: MDCK y células Vero. Se determinó la citotoxicidad del extracto y se estimó que el valor de CC50 para la línea celular MDCK resulta de (400 ± 59 mg/mL y en las células Vero de (137,3 ± 23 mg/mL. A concentraciones no citotóxicas el extracto no indujo la fragmentación del ADN. El efecto del extracto sobre las células infectadas con los virus influenza A/ Japan/10/99(H3N2, influenza B/Beijing/88 fue evaluado mediante la técnica del MTT y el análisis de la fragmentación del ADN, técnicas usadas para identificar el proceso de muerte apoptótica. El proceso de apoptosis fue inhibido por el extracto a todas las concentraciones y tiempos ensayados. A partir de los resultados, se infiere la existencia de mecanismos comunes de inducción de la apoptosis por estos virus que son interferidos por el extracto natural ensayado.

  9. Anti-diabetic action of Punica granatum flower extract: Activation of PPAR-γ and identification of an active component

    Peroxisome proliferator-activated receptor (PPAR)-γ activators are widely used in the treatment of type 2 diabetes because they improve the sensitivity of insulin receptors. Punica granatum flower (PGF) has been used as an anti-diabetic medicine in Unani medicinal literature. The mechanism of actions is, however, unknown. In the current study, we demonstrated that 6-week oral administration of methanol extract from PGF (500 mg/kg, daily) inhibited glucose loading-induced increase of plasma glucose levels in Zucker diabetic fatty rats (ZDF), a genetic animal model for type 2 diabetes, whereas it did not inhibit the increase in Zucker lean rats (ZL). The treatment did not lower the plasma glucose levels in fasted ZDF and ZL rats. Furthermore, RT-PCR results demonstrated that the PGF extract treatment in ZDF rats enhanced cardiac PPAR-γ mRNA expression and restored the down-regulated cardiac glucose transporter (GLUT)-4 (the insulin-dependent isoform of GLUTs) mRNA. These results suggest that the anti-diabetic activity of PGF extract may result from improved sensitivity of the insulin receptor. From the in vitro studies, we demonstrated that the PGF extract enhanced PPAR-γ mRNA and protein expression and increased PPAR-γ-dependent mRNA expression and activity of lipoprotein lipase in human THP-1-differentiated macrophage cells. Phytochemical investigation demonstrated that gallic acid in PGF extract is mostly responsible for this activity. Thus, our findings indicate that PPAR-γ is a molecular target for PGF extract and its prominent component gallic acid, and provide a better understanding of the potential mechanism of the anti-diabetic action of PGF

  10. Biogenic robust synthesis of silver nanoparticles using Punica granatum peel and its application as a green catalyst for the reduction of an anthropogenic pollutant 4-nitrophenol

    Edison, T. Jebakumar Immanuel; Sethuraman, M. G.

    2013-03-01

    A robust synthesis of silver nanoparticles (AgNPs) using the peel extract of Punica granatum is reported in this article. The formation of AgNPs was confirmed by the appearance of brownish yellow color and the Surface Plasmon Resonance (SPR) peak at 432 nm. The biogenic AgNPs were found to have the size approximately 30 nm with distorted spherical shape. The high negative zeta potential values of AgNPs revealed their high stability which could be attributed to the capping of AgNPs by the phytoconstituents of the Punica granatum peel. The biogenic AgNPs were also found to function as an effective green catalyst in the reduction of anthropogenic pollutant viz., 4-nitrophenol (4-NP) by solid sodium borohydride, which was evident from the instantaneous color change of bright yellow (400 nm) to colorless (294 nm) solution, after the addition of AgNPs. The catalytic action of biogenic AgNPs in the reduction of 4-NP could be explained on the basis of Langmuir-Hinshelwood model.

  11. The High-yield Cultivation Techniques for Soft-seed Punica granatum from Tunisia%突尼斯软子石榴丰产栽培技术

    吕中伟; 王鹏; 王东升; 刘许成; 许领军

    2009-01-01

    Through six-year examination in cultivation, the main variety soft-seed Punica granatum from Tunisia should be matched with pollinizer as the proportion of 6:1. The cultivation techniques were severely thinning blossom and fruit, pruning according to branch trait, adopting frost protection measures in the winter and so on. The soft-seed Punica granatum from Tunisia was of favorable varietal characteristics, fruit properties and economic benefits compared with other varieties. It had better market prospect and broader space for further development.%经过6年栽培试验,突尼斯软子石榴栽培上需要配置授粉树(6:1),严格疏花疏果,根据枝条特性整形修剪,冬季要采取防冻措施等.表现出良好的品种特性,果实性状、经济效益远高于其他品种,具有良好的市场前景,有很大的发展空间.

  12. Estudos com o extrato da Punica granatum Linn. (romã): efeito antimicrobiano in vitro e avaliação clínica de um dentifrício sobre microrganismos do biofilme dental = Studies with the extract of the punica granatum linn. (pomegranate): effect antimicrobial “in vitro” and trial avaliation of a toothpaste upon microrganisms of the oral biofilm

    Pereira, Jozinete Vieira

    2005-01-01

    A atividade antimicrobiana in vitro, CIM (Concentração Inibitória Mínima), CIMA (Concentração Inibitória Mínima de Aderência) e a CBM (Concentração Mínima Bactericida) do extrato da romã (Punica granatum Linn. ) foi avaliada em cinco linhagens bacterianas do biofilme dental: Streptococcus mutans, Streptococcus mitis, Streptococcus sanguis, Streptococcus sobrinus e Lactobacillus casei. Em estudo comparativo com o gluconato de clorexidina, os resultados demonstraram efetiva ação inibitória de a...

  13. Punica granatum (pomegranate) flower extract possesses potent antioxidant activity and abrogates Fe-NTA induced hepatotoxicity in mice.

    Kaur, Gurpreet; Jabbar, Zoobi; Athar, Mohammad; Alam, M Sarwar

    2006-07-01

    Most pomegranate (Punica granatum Linn., Punicaceae) fruit parts are known to possess enormous antioxidant activity. The present study evaluated antioxidant and hepatoprotective activity of pomegranate flowers. Alcoholic (ethanolic) extract of flowers was prepared and used in the present study. The extract was found to contain a large amount of polyphenols and exhibit enormous reducing ability, both indicative of potent antioxidant ability. The extract showed 81.6% antioxidant activity in DPPH model system. The ability of extract to scavenge reactive oxygen species (ROS) and reactive nitrogen species (RNS) was tested and it was found to significantly scavenge superoxide (O(2)(.-)) (by up to 53.3%), hydrogen peroxide (H(2)O(2)) (by up to 30%), hydroxyl radicals (()OH) (by up to 37%) and nitric oxide (NO) (by up to 74.5%). The extract also inhibited (.)OH induced oxidation of lipids and proteins in vitro. These results indicated pomegranate flower extract to exert a significant antioxidant activity in vitro. The efficacy of extract was tested in vivo and it was found to exhibit a potent protective activity in acute oxidative tissue injury animal model: ferric nitrilotriacetate (Fe-NTA) induced hepatotoxicity in mice. Intraperitoneal administration of 9 mg/kg body wt. Fe-NTA to mice induced oxidative stress and liver injury. Pretreatment with pomegranate flower extract at a dose regimen of 50-150 mg/kg body wt. for a week significantly and dose dependently protected against Fe-NTA induced oxidative stress as well as hepatic injury. The extract afforded up to 60% protection against hepatic lipid peroxidation and preserved glutathione (GSH) levels and activities of antioxidant enzymes viz., catalase (CAT), glutathione peroxidase (GPX) glutathione reductase (GR) and glutathione-S-transferase (GST) by up to 36%, 28.5%, 28.7%, 40.2% and 42.5% respectively. A protection against Fe-NTA induced liver injury was apparent as inhibition in the modulation of liver markers viz

  14. Medicinal flowers. XXIII. New taraxastane-type triterpene, punicanolic acid, with tumor necrosis factor-alpha inhibitory activity from the flowers of Punica granatum.

    Xie, Yuanyuan; Morikawa, Toshio; Ninomiya, Kiyofumi; Imura, Katsuya; Muraoka, Osamu; Yuan, Dan; Yoshikawa, Masayuki

    2008-11-01

    The methanolic extract from the flowers of Punica granatum L. (Punicaceae) was found to show inhibitory effect on tumor necrosis factor-alpha (TNF-alpha, 1 ng/ml)-induced cytotoxicity in L929 cells. By bioassay-guided separation, a new taraxastane-type triterpene, punicanolic acid (1), was isolated from the active fraction (ethyl acetate-soluble fraction) together with four triterpenes (2--5), two galloyl glucoses (6, 7), two flavones (8, 9), and beta-sitosterol. Among the constituents, 1, oleanolic acid (2), maslinic acid (4), 1,2,6-tri-O-galloyl beta-D-glucopyranoside (6), 1,2-di-O-galloyl-4,6-O-(S)-hexahydroxydiphenoyl beta-D-glucopyranoside (7), and luteolin (8) significantly inhibited TNF-alpha-induced cytotoxicity in L929 cells at 30 microM. PMID:18981621

  15. CONTRIBUTION A LA VALORISATION ALIMENTAIRE DE LA GRENADE MAROCAINE (Punica Granatum L.) : CARACTERISATION PHYSICOCHIMIQUE, BIOCHIMIQUE ET STABILITE DE LEUR JUS FRAIS

    Hmid, Ilham

    2013-01-01

    Le grenadier (Punica granatum) est adapté aux climats arides et semi-arides d'où l'intérêt d'étudier et valoriser ses fruits à cause de l'accentuation des problèmes de sécheresse qui touchent le Maroc ces dernières années. D'un autre côté, la grenade possède de fortes capacités antioxydantes et anti-inflammatoires liées à la présence d'anthocyanes, de tanins et d'acide ellagique qui est utilisé en thérapeutique pour sa capacité à inhiber la prolifération des cellules cancéreuses. Toutefois, l...

  16. Green approach to corrosion inhibition of mild steel in two acidic solutions by the extract of Punica granatum peel and main constituents

    Behpour, M., E-mail: m.behpour@kashanu.ac.ir [Department of Analytical Chemistry, Faculty of Chemistry, University of Kashan, Kashan, I.R. 87317-51167 (Iran, Islamic Republic of); Ghoreishi, S.M.; Khayatkashani, M. [Department of Analytical Chemistry, Faculty of Chemistry, University of Kashan, Kashan, I.R. 87317-51167 (Iran, Islamic Republic of); Soltani, N. [Department of Chemistry, Payame Noor University (PNU), 19395-4697 Tehran (Iran, Islamic Republic of)

    2012-01-05

    Graphical abstract: Ellagic acid (EA) and tannic acid (TA) were studied as corrosion inhibitors. The electron density HOMO and LUMO of EA and TA were used to explain difference in behavior of them. Highlights: Black-Right-Pointing-Pointer The extract of Punica granatum (PG) and their main constituent (ellagic acid (EA)) are found to be good inhibitors for the corrosion of mild steel in 1 M H{sub 2}SO{sub 4} and 2 M HCl. Black-Right-Pointing-Pointer The electrochemical inhibitive mechanism is explained by potentiodynamic polarization curves and electrochemical impedance spectroscopy (EIS) results. Black-Right-Pointing-Pointer The adsorption of ALLOX on mild steel surface was found to accord with the Temkin adsorption isotherm. Black-Right-Pointing-Pointer The effect of temperature on the corrosion behavior of mild steel in 2 M HCl and 1 M H{sub 2}SO{sub 4} without and with the PG extract was studied. - Abstract: The effect of the extract of Punica granatum (PG) and their main constituents involve ellagic acid (EA) and tannic acid (TA), as mild steel corrosion inhibitor in 2 M HCl and 1 M H{sub 2}SO{sub 4} solutions was investigated by weight loss measurements. The results obtained from the weight loss measurements show that the inhibition efficiency of TA even in high concentration is very low. Thus, potentiodynamic polarization and electrochemical impedance spectroscopy (EIS) investigations were used for different concentrations of PG and EA and best concentration of TA. Potentiodynamic polarization curves indicated that PG and EA behave as mixed-type inhibitors. EIS measurements show an increase of the transfer resistance with increasing inhibitor concentration. The temperature effect on the corrosion behavior of steel without and with the PG extract was studied. The inhibition action of the extract was discussed in view of Langmuir adsorption isotherm.

  17. Green approach to corrosion inhibition of mild steel in two acidic solutions by the extract of Punica granatum peel and main constituents

    Graphical abstract: Ellagic acid (EA) and tannic acid (TA) were studied as corrosion inhibitors. The electron density HOMO and LUMO of EA and TA were used to explain difference in behavior of them. Highlights: ► The extract of Punica granatum (PG) and their main constituent (ellagic acid (EA)) are found to be good inhibitors for the corrosion of mild steel in 1 M H2SO4 and 2 M HCl. ► The electrochemical inhibitive mechanism is explained by potentiodynamic polarization curves and electrochemical impedance spectroscopy (EIS) results. ► The adsorption of ALLOX on mild steel surface was found to accord with the Temkin adsorption isotherm. ► The effect of temperature on the corrosion behavior of mild steel in 2 M HCl and 1 M H2SO4 without and with the PG extract was studied. - Abstract: The effect of the extract of Punica granatum (PG) and their main constituents involve ellagic acid (EA) and tannic acid (TA), as mild steel corrosion inhibitor in 2 M HCl and 1 M H2SO4 solutions was investigated by weight loss measurements. The results obtained from the weight loss measurements show that the inhibition efficiency of TA even in high concentration is very low. Thus, potentiodynamic polarization and electrochemical impedance spectroscopy (EIS) investigations were used for different concentrations of PG and EA and best concentration of TA. Potentiodynamic polarization curves indicated that PG and EA behave as mixed-type inhibitors. EIS measurements show an increase of the transfer resistance with increasing inhibitor concentration. The temperature effect on the corrosion behavior of steel without and with the PG extract was studied. The inhibition action of the extract was discussed in view of Langmuir adsorption isotherm.

  18. Estudos com o extrato da Punica granatum Linn. (romã: efeito antimicrobiano in vitro e avaliação clínica de um dentifrício sobre microrganismos do biofilme dental = Studies with the extract of the punica granatum linn. (pomegranate: effect antimicrobial “in vitro” and trial avaliation of a toothpaste upon microrganisms of the oral biofilm

    Pereira, Jozinete Vieira

    2005-01-01

    Full Text Available A atividade antimicrobiana in vitro, CIM (Concentração Inibitória Mínima, CIMA (Concentração Inibitória Mínima de Aderência e a CBM (Concentração Mínima Bactericida do extrato da romã (Punica granatum Linn. foi avaliada em cinco linhagens bacterianas do biofilme dental: Streptococcus mutans, Streptococcus mitis, Streptococcus sanguis, Streptococcus sobrinus e Lactobacillus casei. Em estudo comparativo com o gluconato de clorexidina, os resultados demonstraram efetiva ação inibitória de ambas as substâncias. O extrato da romã foi efetivo na CIMA das cinco linhagens ensaiadas, representada pela ausência de aderência ao vidro na presença de sacarose. A atividade antimicrobiana in vivo do extrato da romã foi testada em 13 pacientes, através do uso de um dentrifício a base desse extrato e foi observadas redução do número de Streptococcus mutans (53,84% e Índice de Sangramento Gengival. Conclui-se, portanto, que o extrato da Punica granatum Linn. , apresentou potente atividade antimicrobiana in vivo e in vitro sobre as linhagens do biofilme dental. Os resultados sugerem a utilização do extrato da romã em indicações terapêuticas na prática odontológica

  19. 石榴皮鞣质的急性毒性研究%Study of Acute Toxicity of Punica granatum Tannin

    邱红梅; 赖舒; 尚京川; 周岐新

    2011-01-01

    OBJECTIVE: To study the acute toxicity of Punica granatum tannins. METHODS: Mice were randomly divided into 7 groups and given P. granatum tannins 15 963.00 mg·kg-1, 12 978.00 mg·kg-1, 10 551.12 mg·kg-1,8 578.25 mg·kg-1,6 974.19 mg·kg-1, 5 670.07 mg·kg-1 and 4 609.81 mg·kg-1 via intragastric administration. Death cases were observed and recorded twice a day (8 am and 2 pm) for 7d. Pathological changes of liver tissue were observed. RESULTS: The LD50 and 95% confidence limit of P. granatum tannins were 8 469.28 mg· kg-1 and 7 252.70~9 685.83 mg·kg-1, respectively. Injury and necrosis of liver cells were observed in dose-dependent manner. CONCLUTION: High-dose of P. granatum tannins could cause liver damage and death in mice.%目的:研究石榴皮鞣质的急性毒性反应.方法:小鼠随机分为7个组,分别灌胃给予15 963.00、12 978.00、10 551.12、8 578.25、6 974.19、5 670.07、4 609.81 mg·kg-1石榴皮鞣质,于给药后每天8时、14时观察并记录其死亡情况,连续观察7 d;同时观察肝脏病理学改变.结果:石榴皮鞣质的半数致死量(LD50)为8 469.28 mg·kg-1,其95%可信限范围为7 252.70~9 685.83 mg·kg~;病理学改变显示,随剂量增高出现剂量依赖性肝细胞损伤、坏死.结论:石榴皮鞣质高剂量应用可造成小鼠肝脏损伤并导致死亡.

  20. Authentication of Punica granatum L.: Development of SCAR markers for the detection of 10 fruits potentially used in economically motivated adulteration.

    Marieschi, Matteo; Torelli, Anna; Beghé, Deborah; Bruni, Renato

    2016-07-01

    The large commercial success of pomegranate increase the likelihood of economically motivated adulteration (EMA), which has been gradually spotted with the undeclared addition of anthocyanin-rich plants or cheaper fruit juices used as bulking and diluting agents. A method based on Sequence-Characterized Amplified Regions (SCARs) was developed to detect the presence of Aristotelia chilensis, Aronia melanocarpa, Dioscorea alata, Euterpe oleracea, Malus×domestica, Morus nigra, Sambucus nigra, Vaccinium macrocarpon, Vaccinium myrtillus, Vitis vinifera as bulking agents in Punica granatum. The method enabled the unequivocal detection of up to 1% of each adulterant, allowing the preemptive rejection of suspect samples. The recourse to such method may reduce the number of samples to be subjected to further phytochemical analyses when multiple batches have to be evaluated in a short time. Vice versa, it allows the cross-check of suspect batches previously tested only for their anthocyanin profile. The dimension of the amplicons is suitable for the analysis of degraded DNA obtained from stored and processed commercial material. Proper SCAR markers may represent a fast, sensitive, reliable and low-cost screening method for the authentication of processed commercial pomegranate material. PMID:26920316

  1. Potential Anti-Inflammatory Effects of the Hydrophilic Fraction of Pomegranate (Punica granatum L. Seed Oil on Breast Cancer Cell Lines

    Susan Costantini

    2014-06-01

    Full Text Available In this work, we characterized conjugated linolenic acids (e.g., punicic acid as the major components of the hydrophilic fraction (80% aqueous methanol extract from pomegranate (Punica granatum L. seed oil (PSO and evaluated their anti-inflammatory potential on some human colon (HT29 and HCT116, liver (HepG2 and Huh7, breast (MCF-7 and MDA-MB-231 and prostate (DU145 cancer lines. Our results demonstrated that punicic acid and its congeners induce a significant decrease of cell viability for two breast cell lines with a related increase of the cell cycle G0/G1 phase respect to untreated cells. Moreover, the evaluation of a great panel of cytokines expressed by MCF-7 and MDA-MB-231 cells showed that the levels of VEGF and nine pro-inflammatory cytokines (IL-2, IL-6, IL-12, IL-17, IP-10, MIP-1α, MIP-1β, MCP-1 and TNF-α decreased in a dose dependent way with increasing amounts of the hydrophilic extracts of PSO, supporting the evidence of an anti-inflammatory effect. Taken together, the data herein suggest a potential synergistic cytotoxic, anti-inflammatory and anti-oxidant role of the polar compounds from PSO.

  2. Punica granatum (pomegranate) leaves extract induces apoptosis through mitochondrial intrinsic pathway and inhibits migration and invasion in non-small cell lung cancer in vitro.

    Li, Yali; Yang, Fangfang; Zheng, Weidong; Hu, Mingxing; Wang, Juanxiu; Ma, Sisi; Deng, Yuanle; Luo, Yi; Ye, Tinghong; Yin, Wenya

    2016-05-01

    Most conventional treatments on non-small cell lung carcinoma always accompany with awful side effects, and the incidence and mortality rates of this cancer are increasing rapidly worldwide. The objective of this study was to examine the anticancer effects of extract of Punica granatum (pomegranate) leaves extract (PLE) on the non-small cell lung carcinoma cell line A549, H1299 and mouse Lewis lung carcinoma cell line LL/2 in vitro, and explore its mechanisms of action. Our results have shown that PLE inhibited cell proliferation in non-small cell lung carcinoma cell line in a concentration- and time-dependent manner. Flow cytometry (FCM) assay showed that PLE affected H1299 cell survival by arresting cell cycle progression in G2/M phase in a dose-dependent manner and inducing apoptosis. Moreover, PLE could also decrease the reactive oxygen species (ROS) and the mitochondrial membrane potential (ΔYm), indicating that PLE may induce apoptosis via mitochondria-mediated apoptotic pathway. Furthermore, PLE blocked H1299 cell migration and invasion, and the reduction of matrix metalloproteinase (MMP) MMP-2 and MMP-9 expression were also observed in vitro. These results suggested that PLE could be an effective and safe chemotherapeutic agent in non-small cell lung carcinoma treatment by inhibiting proliferation, inducing apoptosis, cell cycle arrest and impairing cell migration and invasion. PMID:27133061

  3. Studies on the Chemical Constituents from Xinjiang Punica granatum%新疆石榴皮化学成分研究

    热娜·卡斯木; 帕丽达·阿不力孜; 张笑颖

    2009-01-01

    目的:研究新疆石榴皮(Punica granatum)的化学成分.方法:采用薄层色谱、硅胶柱色谱、MCI-gel CHP20P、Sephadex LH-20凝胶柱色谱等方法进行分离纯化,使用波谱分析技术和理化常数对照等方法对得到的化合物进行结构鉴定.结果:分离得到了10个化合物,分别为:没食子酸(1)、没食子甲酯(2)、鞣花酸(3)、(+)-儿茶素(4)、异槲皮苷(5)、D-甘露醇(6)、熊果酸(7)、齐墩果酸(8)、β-谷甾醇(9)、胡萝卜苷(10).结论:化合物1~10均、为首次从该植物中分离得到.

  4. 36个石榴(Punica granatum L.)品种的品质测定%Determination of Fruit Quality of 36 Pomegranate Cultivars

    汪小飞; 周耘峰; 赵昌恒; 孙龙; 伍全根

    2010-01-01

    对云南省蒙自县石榴品种园中来源于全国石榴产区的36个石榴(Punica granatum L.)品种,在相同栽培条件,相同树龄,均达到成熟的果实进行可溶性糖含量、有机酸含量、可溶性固形物含量、籽粒硬度等指标进行测定与分析.结果表明:'天红蛋'等29个石榴品种中达到优良,适合在蒙自栽培发展;'净皮甜'等9个品种适合作为水果鲜食类在当地栽培;'酸绿籽'等8个作为有机酸含量高的酸石榴品种,适合作为药用类在当地栽培.结果为当地石榴栽培品种的选择奠定了基础.

  5. Protection against oxidative damage in human erythrocytes and preliminary photosafety assessment of Punica granatum seed oil nanoemulsions entrapping polyphenol-rich ethyl acetate fraction.

    Baccarin, Thaisa; Mitjans, Montserrat; Lemos-Senna, Elenara; Vinardell, Maria Pilar

    2015-12-25

    The main purpose of the present study is to evaluate the ability of nanoemulsion entrapping pomegranate peel polyphenol-rich ethyl acetate fraction (EAF) prepared from pomegranate seed oil and medium chain triglyceride to protect human erythrocyte membrane from oxidative damage and to assess preliminary in vitro photosafety. In order to evaluate the phototoxic effect of nanoemulsions, human red blood cells (RBCs) are used as a biological model and the rate of haemolysis and photohaemolysis (5 J cm(-2) UVA) is assessed in vitro. The level of protection against oxidative damage caused by the peroxyl radical generator AAPH in human RBCs as well as its effects on bilayer membrane characteristics such as fluidity, protein profile and RBCs morphology are determined. EAF-loaded nanoemulsions do not promote haemolysis or photohaemolysis. Anisotropy measurements show that nanoemulsions significantly retrain the increase in membrane fluidity caused by AAPH. SDS-PAGE analysis reveals that AAPH induced degradation of membrane proteins, but that nanoemulsions reduce the extension of degradation. Scanning electron microscopy examinations corroborate the interaction between AAPH, nanoemulsions and the RBC membrane bilayer. Our work demonstrates that Punica granatum nanoemulsions are photosafe and protect RBCs against oxidative damage and possible disturbance of the lipid bilayer of biomembranes. Moreover it suggests that these nanoemulsions could be promising new topical products to reduce the effects of sunlight on skin. PMID:26407526

  6. Recent Advances in Metabolic Products of Flavonoids in Punica granatum%石榴类黄酮代谢产物的研究进展

    刘安成; 李慧; 王亮生; 庞长民; 卫伟光

    2011-01-01

    Pomegranate (Punica granatum) is a cultivated fruit with a long history and great nutritional value. China has 8 major pomegranate-producing areas, including Xingyang and Kaifeng cities, Henan province; Lintong county, Shaanxi province; Zaozhuang county, Shandong province; Huaiyuan county, Anhui province; Huili county, Sichuan province;Mengzi county, Yunnan province; and Kargilik county, Xinjiang Uyghur autonomous region. In total, 33 flavonoids have been detected from pomegranate fruit juice, pericarp and foliage; these include 6 flavanols, 1 flavanone glycoside, 2 flavonols, 3 flavonol glycosides, 3 flavones, 5 flavone glycosides, 1 flavanonol glycoside, 3 anthocyanidins and 9 anthocyanins. These flavonoid compounds are widely used in the health food and medicinal industries. This paper summarizes the recent progress in the constitution, content, detection methods and pharmacological studies of flavonoids in the fruit,leaf and petal of P. granatum. To promote deeper research and use of the active components and for functional characterization for cancer prevention, future study should focus on the rapid analysis, semi-preparation and/or preparation separation, and quantitative analysis of flavonoids in fruits; germplasm resource evaluation; and identification of active components in leaves and flowers of pomegranate.%石榴(Punica granatum)是一种栽培历史悠久且营养价值很高的水果,我国已形成了河南荥阳和开封、陕西临潼、山东枣庄、安徽怀远、四川会理、云南蒙自和新疆叶城8大石榴主产区.迄今为止,从石榴果汁、果皮和叶片中共检测出类黄酮多达33种,其中包括6种黄烷醇、1种黄烷酮苷、2种黄酮醇、3种黄酮醇苷、3种黄酮、5种黄酮苷、1种二氢黄酮醇苷、3种花青素苷元和9种花青素苷,这些化合物在保健食品和医疗应用中具有重要作用.该文对石榴果实、叶片和花瓣中所含类黄酮的组成、含量、检测方法及药理等

  7. Amelioration of radiation induced DNA damage and biochemical alterations by Punica Granatum (L) extracts and synthetic ellagic acid in Swiss albino mice

    Radiation therapy has been used in cancer treatment for many decades; Although effective in killing tumor cells, ROS produced in radiotherapy threaten the integrity and survival of surrounding normal cells. ROS are scavenged by radioprotectors before they can interact with biochemical molecules, thus reducing harmful effects of radiation. The pomegranate, Punica granatum L., an ancient, mystical, and highly distinctive fruit, is the predominant member of the Punicaceae family. It is used in several systems of medicine for a variety of ailments. The objective of the present study was to investigate the protective effects of ethanolic extracts of pomegranate whole fruit (EPWF) and seeds (EPS) and Synthetic Ellagic acid (EA) against Electron Beam Radiation (EBR) induced DNA damage and biochemical alterations in Swiss Albino mice. The extracts and synthetic compound were assessed for its radical scavenging property by DPPH radical scavenging and Ferric Reducing Antioxidant Power assays. The animals were treated with 200 mg/kg body wt. of pomegranate extracts and Ellagic acid for 15 days before exposure to 6 Gy of EBR. Radiation induced DNA damage was assessed by comet assay in the peripheral blood lymphocytes of mice. The biochemical estimations were carried out in the serum and RBC lysate of the animals. The plant extracts and synthetic compound exhibited good radical scavenging and reducing properties.The pretreated animals before irradiation caused a reduction in the comet length, olive tail moment, % DNA in tail when compared to irradiated group. The biochemical parameters such as lipid peroxidation was significantly depleted in the treated groups when compared to irradiated group followed by significant elevation in reduced glutathione. Our findings indicate the ameliorating effects of pomegranate extracts and synthetic ellagic acid on radiation induced DNA damage and biochemical changes in mice may be due to its free radical scavenging and increased antioxidant

  8. In vitro antioxidant, collagenase inhibition, and in vivo anti-wrinkle effects of combined formulation containing Punica granatum, Ginkgo biloba, Ficus carica, and Morus alba fruits extract

    Ghimeray AK

    2015-07-01

    Full Text Available Amal Kumar Ghimeray,1 Un Sun Jung,1,2 Ha Youn Lee,1 Young Hoon Kim,1 Eun Kyung Ryu,1 Moon Sik Chang11R&D Center, Natural Solution Co., Ltd, Gojan-dong, Namdong-gu, Incheon, Republic of Korea; 2Department of Horticultural Biotechnology, Kyung Hee University, Yongin, Republic of KoreaBackground: In phytotherapy, the therapeutic potential is based on the combined action of different herbal drugs. Our objective was to evaluate the antioxidant, anti-collagenase (in vitro, and anti-wrinkle (in vivo effect of combined formulation containing Ginkgo biloba, Punica granatum, Ficus carica, and Morus alba fruits extract.Methods: Antioxidant evaluation was based on the scavenging activity of free radicals (1,1-diphenyl-2-picrylhydrazyl, H2O2, and O2- and the anti-collagenase activity was based on the reduction of collagenase enzyme in vitro. In an in vivo study, 21 female subjects were examined in a placebo-controlled trail. Facial wrinkle, especially the crow's feet region of eyes, was treated with topical formulated 2% cream for 56 days and compared with the placebo.Results: In the in vitro study, the combination of fruits extract showed a higher antioxidant activity which was comparable with the positive standard (ascorbic acid, butylated hydroxyanisole, and Trolox. The data also showed a dose-dependent inhibition of collagenase. In the in vivo study, treatment with 2% formulated cream for 56 days significantly reduced the percentage of wrinkle depth, length, and area with 11.5, 10.07, and 29.55, respectively.Conclusion: The combined formulation of fruit extracts showed excellent antioxidative and anti-collagenase activity as well as a significant effect on anti-wrinkle activity on human skin.Keywords: antioxidant, anti-collagenase, anti-wrinkle, fruits, topical formulation

  9. 提高石榴坐果率的试验研究%Experimental Study on Improving the Fruit-set Percentage of Punica granatum

    王立忠

    2012-01-01

    Experiments were carried out on the cultivation techniques including artificial supplementary pollination in florescence and spray of gibberellin, etc., aimed to solve the problem of low fruit-set percentage of the soft-seed pomegranate (Punica granatum) in Huaibei City. The results showed that on the basis of intensive soil, fertilizer and water management and regular pruning, the fruit-set percentage could be increased by 31.7%~32.2%, 7.9%~22.3% and 51.3%~ 63.5% respectively with the application of artificial supplementary pollination in florescence, spray of gihberellin and their integrated application, compared with the control group. The optimal technical measures were figured out for maximum increase of the fruit-set percentage.%针对淮北软籽石榴坐果率低的问题,进行了花期人工辅助授粉和喷施赤霉素等栽培技术试验,结果表明:除加强土肥水管理和正常修剪外,花期采取人工辅助授粉、喷施赤霉素和授粉与喷施综合应用措施,其坐果率分别比对照提高31.7%~32.2%、7.9%~22.3%、51.3%~63.5%,摸索出提高坐果率的最佳技术措施。

  10. Avaliação da atividade antioxidante do extrato hidroalcoólico da romã (Punica granatum, L. sobre células da linhagem Caco-2 Antioxidant activity evaluation of the pomegranate (Punica granatum, L. hidroalcoholic extract at Caco-2 cell line

    Fernanda Archilla Jardini

    2007-08-01

    Full Text Available A absorção dos compostos antioxidantes presentes no extrato hidroalcoólico da polpa da romã (Punica granatum, L. foi avaliada utilizando-se o modelo de cultura de células, cuja linhagem escolhida foi a Caco-2, provenientes de um adenocarcinoma do cólon. O extrato hidroalcoólico da polpa apresentou um conteúdo de 832 µg equivalente de ácido gálico.mL-1 de extrato e sua atividade antioxidante mostrou valores de 5,9% (0,1 ppm a 93,09% (8 ppm de capacidade de redução do radical DPPH•. As células tratadas com o extrato apresentaram uma inibição de crescimento celular de 4,16% (200 ppm, e a absorção dos compostos antioxidantes foi de 63,25%. Para o ácido gálico, os resultados mostraram uma inibição de 2,98% (400 ppm e uma absorção de 72,54% dos compostos antioxidantes. Os resultados mostraram que o método de avaliação de absorção através de cultura de células foi eficaz, e que os compostos antioxidantes foram absorvidos pelas células, que se apresentaram viáveis, após um período de exposição prolongado aos compostos.The absorption of antioxidant compounds present in hydroalcoholic extract of pomegranate pulp (Punica granatum, L. was evaluated by a cell culture model, using the Caco-2 cells (from an adenocarcinom of the colon. The hydroalcoholic extract of the pulp showed a content of reducing compounds of approximately 832 µg equivalent to gallic acid.mL-1 of the extract and its antioxidant activity was from 5.9% (0.1 ppm to 93.09% (8 ppm, measured by the capacity of reducing the DPPH• radical. The cells that were treated with the extract showed a 4.16% of growing inibition (at a concentration of 200 ppm, and an absorption of the antioxidants compounds of approximately 63.25%. The gallic acid showed, at 400 ppm of concentration, a growing inhibition of 2.98% and anabsorption of 72.54% of the antioxidant compounds. These results pointed out that the method of evaluating the absorption by using cell culture was

  11. Controlling Biofilm Formation by Inhibiting the Quorum-Sensing Activity of Pseudomonas aeruginosa using the Ethanolic Extracts of Piper nigrum (Piperaceae Fruit, Punica granatum (Lythraceae Pericarp, and Pisum sativum (Fabaceae Seed

    M.V. Dazal

    2015-07-01

    Full Text Available Bacterial biofilm formation can cause serious problems in clinical and industrial settings, which drives the development or screening of biofilm inhibitors. Pseudomonas aeruginosa is a well-known pathogen that exhibit biofilm formation through quorum-sensing, which is a bacterial cell-to-cell communication that regulates the production of many virulence factors. The inhibition of biofilm formation is a viable option for bacterial eradication. The antibacterial effect of Piper nigrum is related to the presence of phenolic and flavonoid components. Punica granatum has been reported to possess a wide range of biological actions, with tannins and alkaloids stated to be the reason of its antibacterial property. Pisum sativum, on the other hand, contains various constituents, but the tannins and phenolic compounds stated as responsible for its antibacterial property. The minimum inhibitory concentration using the susceptibility testing of P. nigrum, P. granatum, P. sativum ethanolic extracts were 6.67×10-4 g/mL, 2.1978×10-5 g/mL, and 6.25×10-4 g/mL, respectively. On the swarming assay, P. granatum and P. sativum inhibits swarming motility at concentrations of 2.1978×10-2 up to 2.1978×10-4 g/mL, and 6.25×10-2 to 6.25×10-3 g/mL, respectively. The P. nigrum extract did not inhibit the motility.

  12. Study on the Effects of Different Methods on Punica granatum L.DNA Extraction from Leaves%不同方法对石榴叶片DNA提取效果的影响

    陈延惠; 张四普; 胡青霞; 栗燕; 阿依古丽·喀斯木; 朱道圩

    2005-01-01

    以4个石榴(Punica granatum L.)品种为实验材料,用SDSⅠ,SDSⅡ,CTABⅠ,CTABⅡ 4种方法提取石榴叶片DNA.结果表明,SDS法提取得率为500~600 μg·g-1,但OD值偏低,为1.50~1.70;RAPD分析无扩增;CTAB法所得DNA得率为200~500 μg·g-1,OD值为1.80~1.90;RAPD分析扩增带清晰.CTABⅠ和CTABⅡ相比,操作简单、省时,得率高,综合考虑CTABⅠ是石榴叶片DNA提取的最佳方法.

  13. Contribution à l'étude de i'activllé antioxydante et inhibitrice de l'a-amylase des proanthocyanidines extraites de l'épicarpe de Punica granatum L. (grenadier).

    bachiri, asma

    2015-01-01

    Le travail est réalisé dans le cadre d'évaluer les propriétés antioxydant et l'influence des proanthicyanidines extraites a partie de l'épicarpe de punica granatum sur l'hyperglycémie provoquée par voie orale(HGPO) ainsi que l'activité inhibitrice vis-à-vis de l'a amylase. Le pouvoir antioxydant de notre extrait est évalué par la méthode de FRAP (Ferric reducing antioxidantpower), et le résultat obtenu montre une activité très puissante pour réduire le fer, similaire avec celle...

  14. Preliminary Assessment of Punica granatum on Characteristics in Pupiao of Yunnan Province%云南蒲缥地方优良石榴品种白水籽和红水籽性状初步评价

    邹云昌

    2011-01-01

    通过对云南蒲缥地方石榴品种白水籽和红水籽的植物学性状、经济性状的观测,和与省内外16个优良石榴品种的比较,初步认为白水籽和红水籽品种已符合石榴良种指标,值得深入研究和开发。%Punica granatum,known as pomegranate,is a kind of fruit tree with high economic value.In this paper,comparative experiment of different varieties on their characteristics was carried out.Two local cultivars(with red meat and white meat respectively) are thought to be good enough to develop in Pupiao.

  15. 宾川石榴品种资源调查及其果实主要品质的比较分析%Investigation of Punica granatum L. Germplasm Resources in Binchuan and Comparative Analysis of Major Fruit Qualities

    陈黎虹; 袁责华; 李品兰; 王军; 杨黎静; 徐娟萍; 张波; 张庆辉; 杨荣萍

    2012-01-01

    [Objective] This study aimed to provide a basis for enriching the Punica granatum L. germplasm resources through investigating Punica granatum L. vari- eties in Binchuan. [Method] In this study, biological traits of Punica granatum L. vari- eties in Binchuan (including two local varieties-'Binchuan Red Coat' and 'Binchuan Green Coat', 'Cyan Coat and Soft Seeds' and 'Little Red Coat' introduced from Huili, Sichuan, 'Acid Pomegranate' introduced from Shandong Province and "Ma Pomegranate" from Fengqiu, Henan) were investigated and their major fruit qualities were also analyzed. [Result] "Cyan Coat and Soft Seeds' and "Ma Pomegranate' grew well with good fruit quality, which adapted well to the climate and environment in Binchuan; "Little Red Coat' showed average performance in growth and major fruit qualities with inferior flavour; "Binchuan Red Coat' and 'Binchuan Green Coat' also showed average performance in major fruit qualities and and inferior flavour; 'Acid Pomegranate' grew while was inferior in flavour. [Conclusion] This study pro- vides references for presenting the directions for studies of P. granatum L. germplasm resources and determining the genetic relationship among germplasm resources, as well as breeding, introduction and cultivation of P. granatum L., further providing a variety basis for pomegranate production.%[目的]调查研究宾川石榴品种资源,以期为扩大石榴品种资源奠定基础。[方法]对大理宾川的红皮石榴和绿皮石榴、以及引种的四川会理青皮软籽和小红皮、山东酸石榴、河南封丘麻石榴进行了生物学性状调查和果实主要品质分析。[结果]青皮软籽和麻石榴果树长势和果实主要品质较好,对宾川的气候环境有较强的适应性;而小红皮果树长势一般,果实主要品质一般,风味差;宾川本地红皮和绿皮石榴果树和果实主要品质一般,风味差;酸石榴虽然长势好,但风味差。[结论]该研究结果为

  16. Comparation of Pollen Ultrastructural Morphology Among Pomegranate (Punica granatum)Cultivars in Shandong Province%山东20个石榴品种花粉亚微形态学比较研究

    尹燕雷; 苑兆和; 冯立娟; 招雪晴; 陶吉寒

    2011-01-01

    The ultrastructures of pollen grains from 20 pomegranate (Punica granatum) cultivars in Shandong Province were examined using a Hitachi S-570 scanning electron microscope. The results showed that pollen grains were tricolporate, N3P4C5 type according to Erdtman's NPC system. They were sub-spheroidal in equatorial view, and 3-lobed sub-spheroidal or triangle in polar view. The polar axis length of pollen grains was 23.08- 28.57 μm. The equatorial axis length of pollen grains was 13.07-19.74 μm. In addition, there were significant differences in some morphological aspects of pollen grains,for example, pollen size and colporate, between cultivars. Thus, it was suggested that morphological characters of pollen grains were very important for cultivars differentiation in pomegranate.%利用日立S-570扫描电镜对山东省20个石榴(Punica granatum)品种花粉的亚微形态特征进行了观察分析,结果表明:供试品种的花粉具3条萌发沟,属N3P4C5类型;赤道面观均呈近长球形,极面观呈三裂圆形或三角形:花粉粒极轴长23.08~28.57μm,赤道轴宽13.07~19.74 μm;供试品种间花粉的大小、表面纹饰等均有明显差别.初步认为花粉粒的形态特征可以作为石榴品种间分类的一个标准.

  17. Genetic Diversity and Genetic Relationship of Pomegranate(Punica granatum)in Sichuan and Yunnan Evaluated by AFLP Markers%川滇石榴品种遗传多样性及亲缘关系的AFLP分析

    赵丽华; 李名扬; 王先磊

    2010-01-01

    @@ 石榴(Punica granatum)为石榴科(Punicaceae)石榴属(Punica)落叶灌木或小乔木,原产伊朗、阿富汗等中亚一带,从西汉张骞出使西域将涂林安石榴引入我国,石榴作为水果和观赏树木在我国已有2000多年的栽培历史.经长期天然杂交和基因突变,以及采用实生、分株、嫁接等多种繁殖方法,产生了复杂而多样的品种和类型,据不完全统计,我国现有石榴品种资源200多个,遍及南北各地20多个省区,形成了山东枣庄、新疆叶城、陕西临潼、安徽怀远、河南开封、云南蒙自和四川会理等著名的栽培区(汪小飞,2007).

  18. Photoprotection by Punica granatum seed oil nanoemulsion entrapping polyphenol-rich ethyl acetate fraction against UVB-induced DNA damage in human keratinocyte (HaCaT) cell line.

    Baccarin, Thaisa; Mitjans, Montserrat; Ramos, David; Lemos-Senna, Elenara; Vinardell, Maria Pilar

    2015-12-01

    There has been an increase in the use of botanicals as skin photoprotective agents. Pomegranate (Punica granatum L.) is well known for its high concentration of polyphenolic compounds and for its antioxidant and anti-inflammatory properties. The aim of this study was to analyze the photoprotection provided by P. granatum seed oil nanoemulsion entrapping the polyphenol-rich ethyl acetate fraction against UVB-induced DNA damage in the keratinocyte HaCaT cell line. For this purpose, HaCaT cells were pretreated for 1h with nanoemulsions in a serum-free medium and then irradiated with UVB (90-200 mJ/cm(2)) rays. Fluorescence microscopy analysis provided information about the cellular internalization of the nanodroplets. We also determined the in vitro SPF of the nanoemulsions and evaluated their phototoxicity using the 3T3 Neutral Red Uptake Phototoxicity Test. The nanoemulsions were able to protect the cells' DNA against UVB-induced damage in a concentration dependent manner. Nanodroplets were internalized by the cells but a higher proportion was detected along the cell membrane. The SPF obtained (~25) depended on the concentration of the ethyl acetate fraction and pomegranate seed oil in the nanoemulsion. The photoprotective formulations were classified as non-phototoxic. In conclusion, nanoemulsions entrapping the polyphenol-rich ethyl acetate fraction show potential for use as a sunscreen product. PMID:26406978

  19. Punica granatum – Granatapfelbaum (Punicaceae)

    Jagel, Armin

    2010-01-01

    Der Granatapfel ist bei uns zur Weihnachtszeit mittlerweile regelmäßig an Obstständen zu finden. Trotzdem gehört er für Mitteleuropäer noch immer zu den exotischen Früchten und oft weiß man nicht so recht, was man mit ihm anfangen soll. Ganz anders im Mittelmeergebiet. Hier wird der Granatapfel einerseits als Obstbaum, andererseits wegen seiner prachtvollen leuchtend roten Blüten häufig gepflanzt. Ihn umgibt eine Fülle von Symbolik und mythologischen Geschichten von der Antike bis ins Mittela...

  20. 河阴石榴茎尖脱毒快繁技术研究%The Research on the Fast Breeding and Virus-free Technologies of the Stem-tips of Punica granatum L. of Heyin

    范春丽

    2012-01-01

    The pomegranate explants from stem-tips were studied to obtain the optimum tissue culture system for punica granatum L. of heyin.The results showed that the most optimum multiplication medium was MS + 1.0 mg/L 6-BA + 0.30 mg/L NAA,whose multiplication index reached 4.20.The best rooting medium was 1 /2MS +0.50 mg/L NAA,whose rooting rate was 90.0%.The transplant survival rate could reach 96.0%.%以河阴石榴茎尖为材料,对其组织培养快繁体系进行了研究。结果表明,河阴石榴茎尖的最适增殖培养基为MS+1.0 mg/L 6-BA+0.30mg/L NAA,其增殖系数达4.20。最适宜生根培养基为1/2MS+0.50mg/L NAA,其生根率可达90.0%,移栽成活率达95.0%。

  1. Study of pomegranate (Punica granatum L.) peel extract containing anthocyanins on fatty streak formation in the renal arteries in hypercholesterolemic rabbits

    Fatemeh Sharifiyan; Ahmad Movahedian-Attar; Nafiseh Nili; Sedigheh Asgary

    2016-01-01

    Background: The influence of the supplementation of pomegranate peel extract containing anthocyanins on atherosclerotic plaque formation induced by hypercholesterolemia was investigated in renal arteries in rabbits. Materials and Methods: After the determination of polyphenol and anthocyanin′s content of P. granatum peel hydroalcoholic extract, 30 male rabbits were randomly divided into three groups. They were fed basic diet, hypercholesterolemic diet and hypercholesterolemic diet along w...

  2. 石榴皮鞣质对糖尿病大鼠血脂的影响及对肝脏的保护作用%Effects of Tannin in Punica granatum L.on Blood Lipids and Its Protecting Liver Ability in Diabetic Rats

    谭红军; 杨林; 罗春华; 张玉红

    2012-01-01

    Objective To study the effects of Tannin in Punica granatum L. on blood lipids and its protecting liver ability in diabeticrats. Methods Diabetic rat models were induced by i. p. injection of streptozotocin (75mg/kg). The diabetic rats were randomly divided into four groups;model group, tannin in punica granatum L. 50, 75, lOOmg/kg treatment Group. The blank control group was composed by normal rats. Serum alanine transaminase( ALT) activity of rats in each group, and glucose (GLU) , triglyceride ( TG) ,total cholesterol TC) ,high density lipoprotein - cholesterol ( HDL -C) , low density lipoprotein - cholesterol ( LDL C) levels were studied 21 days after medication administration. Results Compared with model Group, Tannin in punica granatum L. can lower GLU , TG,TC , LDL -C concentration and ALT activity significantly (P <0. 05 ,P <0. 01) , increase HDL - C levels (P < 0.05 ,P <0. 01). Conclusion Tannin in punica granatum L. has the function of good protection in liver of diabetic rats, It can lower blood glucose and regulate blood lipids.%目的 初步观察石榴皮鞣质对糖尿病大鼠血脂的影响及肝脏的保护作用.方法 采用腹腔注射链脲佐菌素(75mg/kg)的方法建立糖尿病大鼠模型,将成模大鼠随机分为4组:模型组、石榴皮鞣质低、中、高剂量组,另取正常大鼠作为空白对照组.连续给药21天后,观察石榴皮鞣质对血糖血脂和肝功能的影响.结果 与模型组比较,石榴皮鞣质可显著降低GLU、TG、TC、LDL-C浓度、ALT活性(P <0.05,P<0.01),提高HDL-C浓度(P <0.05,P<0.01).结论 石榴皮鞣质对糖尿病大鼠的肝脏具有保护作用,可降低血糖调节血脂.

  3. Effect of pectin methyl esterase and Ca²⁺ ions treatment on antioxidant capacity, shelf-life and quality of minimally processed pomegranate (Punica granatum L.) arils.

    Kumar, Sunil; Kumar, Ramesh; Nambi, V E

    2016-03-01

    Pomegranate fruits are difficult to peel and once peeled, extracted arils have very short shelf-life. Therefore, present investigation was carried out to extend the shelf life of minimally processed pomegranate arils using pectin methyl esterase (PME) and CaCl2 treatment during refrigerated storage. The arils of freshly harvested pomegranate fruits (Punica granatum L.) were treated with different concentrations of food-grade PME (50-300 units) and calcium ions (0.5-2.0% CaCl₂) for a period of 5-30 min using response surface methodology. Treated and untreated arils were then packed in low density polyethylene bags (25 μ) and maintained under low temperature (5°C; 90% RH) for evaluating the physical, biochemical and microbial quality of pomegranate arils at four day interval. Physiological loss in weight increased during storage but no food-borne pathogens were found during 28 day of cold storage in treated arils. Color and firmness of both treated and untreated arils decreased during storage but it was better maintained in treated arils. The firmness was found to be 0.630 N in treated samples compared to untreated one (0.511 N) after 20 d of storage. Total antioxidant capacity, ferric reducing antioxidant power, polyphenol oxidase and lipoxygenase activities increased during storage. Treatment with 249.33 units of PME and 1.70% CaCl₂for an immersion time of 24.93 min was found to be most effective treatment for maintaining the quality of minimally processed arils for longer period. Sensory score was also higher in treated pomegranate arils that were quite acceptable even after 20 day of referigerated storage as against 12 day for untreated ones. PMID:27097437

  4. 土壤水分对石榴光合速率的影响%Effect of soil water content on net photosynthetic rate of Punica granatum

    邓恒芳; 王克勤

    2005-01-01

    通过对不同土壤水分条件下石榴Punica granatum叶片光合速率的研究.结果表明,净光合速率和气孔导度都随着土壤含水量的减少而降低,二者的变化基本一致.净光合速率和气孔导度的日变化曲线都是典型的"双峰"型曲线,且随着土壤含水量的下降都有不同程度的下降.同时也表明土壤含水量为19.14%~13.23%时净光合速率的变化主要与气孔因素有关.图4表1参19

  5. 石榴皮鞣质对糖尿病大鼠血管保护作用及其机制初探%Study on Vascular Protection and Its Mechanism of Tannin in Punica Granatum L.in Diabetes Rats

    王明智; 梅志刚; 曾永保; 杨林; 谭红军

    2011-01-01

    目的 初步探讨石榴皮鞣质(tannin in punica granatum L.)对糖尿病大鼠血管保护作用及其机制.方法 采用腹腔注射链脲佐菌素(75mg/kg)的方法建立糖尿病大鼠模型,将成模大鼠随机分为三组:模型对照组、石榴皮鞣质低剂量组、石榴皮鞣质高剂量组,另取正常大鼠作为正常对照组.连续给药21天后,观察大鼠一般生理状况,测定血清葡萄糖(GLU)、三酰甘油(TG)、C反应蛋白(CRP)、一氧化氮(NO)、内皮素-1(ET-1)浓度以及NO/ET-1比值,并分析其相关性.结果 与模型对照组比较,低剂量的石榴皮鞣质可显著改善糖尿病大鼠生理状态,显著降低血清GLU、TG、CRP、ET-1浓度,显著提高血清NO浓度、NO/ET-1比值.单因素相关分析显示:血清GLU浓度与ET-1浓度呈显著正相关,与NO/ET-1比值呈显著负相关;血清TG浓度与ET-1浓度呈显著正相关,与NO/ET-1比值呈显著负相关.结论 石榴皮鞣质对糖尿病大鼠血管有较好的保护作用,其机制可能与其降低血糖、TG浓度,直接或间接的升高ET-1浓度、降低NO/ET-1比值有关.%Objective To study the vascular protection and its mechanism of tannin in punica granatum L in diahetes rats. Methods Diabetic rat models were induced by i. p. injection of streptozotocin (75mg/kg). The diabetic rats were randomly divided into three groups: model control group,tannin in punica granatum L low - dose group and high - dose group. Nurmal control group was composed by normal rats. Physiological state of of rats in each group, serum glucose. ( GLU) .triglyceride ( TG) , Creactive protein ( CRP) , NO, FT - 1 levels. NO/ET - 1 ratio and the correlation analysis were studied after 21 days medication administration. Results Compared with model control group, low dose of tannin in punica granatum L. can improve the physiological state of diabetic rats significantly, lower serum CRP. GLU, TC; and ET - 1 levels significantly, and inrrease serum NO level and NO/ET - 1

  6. 石榴皮多酚有效部位单次给药毒性及对无水乙醇致大鼠胃溃疡的保护作用%Single dose toxicity of polyphenols effective parts from Punica granatum and their protective effect on ethanol-induced gastric ulcer in rats

    史李娜; 王雪飞; 马桂芝; 康金森; 高晓黎

    2015-01-01

    上皮细胞合成、提高再生黏膜功能、增强抗氧化能力和诱导、促进NO合成有关。%Aims To study single dose toxicity of poly-phenols effective parts from Punica granatum,to eval-uate their safety,and thus to provide a theoretical basis for drug development and clinical use.To observe their protective effect on ethanol-induced gastric ulcer in rats.Methods 50 healthy Kunming mice were ran-domly divided into five groups and given different doses of polyphenols’effective parts from Punica granatum via intragastric administration.Toxicity and death in each group of mice were observed and recorded after administration for 14 d.The median lethal dose was calculated by Bliss method.70 rats were randomly di-vided into normal group,model group(constant volume of normal saline),sanjiuweitai particles(1 850 mg· kg-1 )group,colloidal bismuth subcitrate (33 mg · kg-1 )group and polyphenols effective parts from Puni-ca granatum low-dose,medium-dose,high-dose(430, 852,1 704 mg·kg-1 )groups.On the 9th day of 10 days’gavage,all except the normal group were fed ethanol (1.5 mL/only)to induce gastric mucosal inju-ry in rats with acute gastric ulcer.Gastric ulcer index, the rate of ulcer inhibition were calculated for each group.The morphological changes of gastric mucosa were observed.The gastric mucosa levels of PGE2 , NO,SOD and MDA were determined.Results The LD50 and 95%confidence limit of the polyphenols’ef-fective parts from Punica granatum were 8 520.9 mg· kg-1 and 7 291.2 ~9 914.4 mg·kg-1,respectively. Pathology showed that the organs receiving dose of 16 000 mg · kg-1 had different degrees of damage . Compared with the model group,the extract from Puni-ca granatum significantly repaired the gastric mucosa, and significantly increased the gastric mucosa levels of NO and reduced MDA content,and improved SOD content and the levels of PGE2 .Conclousion The dose of 5 063 mg · kg-1 of polyphenols effective part from Punica granatum showed no

  7. HPLC测定石榴皮提取物颗粒剂中不同时期鞣花酸含量的变化%Detection of Ellagic Acid in the Granules of Extracts of Punica granatum L. Pericarp in Different Periods by HPLC

    任杰; 姚敬明; 武果桃; 樊振华; 赵娟; 吴忻; 刘文俊; 孟冬霞

    2012-01-01

    The ellagic acid in the granules of extracts of Punica granatum L. pericarp in different periods was detected by HPLC. Chromatography was performed on a PT -230A Colume heater Apollo C18 column (150 mm×4.6 mm, 5 μm) at 254 nm and 30℃. The mobile phase consisted of a mixture of acetonitrile - 1.2% phosphoric acid (20 : 80) at a flow rate of 1.0 mL/min. The linear range of ellagic acid was 0.52 -5.20 txg with (R2 =0. 99786). The average recovery was 97.8% and RSD was 1.6%. The samples of March 25, 2008 and March 25, 2011 were 0. 495 mg/g, 0. 439 mg/g. The results showed that the granules of extracts of Punica granatum L. pericarp was stable within three years. The method is simple and accurate and reproducibe for quality control of Punica granatum L. pericarp.%采用高效液相色谱法测定了石榴皮提取物颗粒剂在不同时期的有效成分鞣花酸含量的变化。色谱柱PT-230A Colume heater Apollo C18柱(150 mm×4.6 mm,5μm),柱温30℃;流动相为乙腈-1.2%磷酸溶液(20∶80);检测波长254 nm;流速1.0 mL/min。结果显示,鞣花酸含量测定的线性范围0.52~5.20μg(R2=0.99786),平均加样回收率为97.8%,RSD为1.6%。样品于2008年3月25日测定的颗粒剂鞣花酸含量为0.495 mg/g,2011年3月25日测定的含量为0.439 mg/g。表明该石榴皮提取物颗粒剂稳定性良好,有效期可达到三年以上。该方法简便、准确,可用于中药石榴皮的质量控制。

  8. 石榴皮鞣质对腺嘌呤性慢性肾衰大鼠保护作用的研究%Protective Effect of Tannin in Punica granatum L.on Chronic Renal Failure in Rats Induced by Adenine

    周本宏; 郭志磊; 王慧媛; 冯琪

    2009-01-01

    目的 观察石榴皮鞣质对腺嘌呤性慢性肾功能衰竭(CRF)大鼠的影响.方法 用250 mg·kg~(-1)腺嘌呤溶液连续灌胃21 d使Wistar大鼠产生类似慢性肾袁的症状.21d后,治疗组大鼠每天用石榴皮鞣质(40,20,10mg·kg~(-1).d~(-1))灌胃,阳性组用20%尿毒清混悬液按2.1 g·kg~(-1)·灌胃.60 d后收集尿液,处死大鼠,取血、留取肾组织,测定血Ca~(2+)、P~(3+)及血肌酐(Scr)、尿素氮(BUN),血脂和24h尿蛋白定量、尿Ca~(2+)、P~(3+),进行统计学处理,并进行形态学观察.结果 石榴皮鞣质对慢性肾衰竭大鼠的血Ca~(2+)、P~(3+)及Scr、BUN和24 h尿蛋白定量、尿Ca~(2+)、P~(3+)有不同程度的改善.结论 石榴皮鞣质对腺嘌呤导致的大鼠慢性肾衰竭有一定的保护作用.%OBJECTIVE To observe the effeets of tannin in Punica granatum L.on chronic renal failure(CRF)in rats induced by adenine.METHODS The Wistar rats were administered intragastrically with adenine(200 mg·kg~(-1)·d~(-1))for 21 d to induce the symptoms similar to chronic renal failure.Then,the rats were administered intragastrically with tannin(40,20 and 10 blood urea nitrogen(BUN),calcium ion(Ca~(2+)),phosphorus ion(P~(3+)),blood lipids and urine protein of 24 h were determined and analyzed.Meanwhile morphology was observed.RESULTS Serum levels of Scr,BUN and P~(3+) were decreased but Ca~(2+) level was increased by tannin in Punica granatum L.CONCLUSION Tannin in Punica granatum L can improve the renal function injuried by metabolic products in adenine-modeled CRF rats.

  9. Changes of Photosynthetic Capability and Pigment Contents of Malus spectabilis,Punica granatum and Amygdalus persica Under Salt Stress%盐胁迫对海棠等3树种光合能力及色素变化的影响

    孙方行; 周勃; 孙明高

    2010-01-01

    以2年生海棠(Malus spectabilis)、石榴(Punica granatum)和桃树(Amygdalus persica)的盆栽苗为试验材料,测定它们在不同浓度NaCl胁迫下的光合能力及色素变化.结果表明,3树种的耐盐性依次为海棠>石榴>桃树;盐胁迫下3种非盐生树种净光合速率(Pn)和气孔导度(Gs)下降,胞内CO2浓度(Ci)变化没有规律,非气孔因素是导致光合下降的限制因子;盐胁迫导致3树种叶绿素含量下降,但叶绿素a/b的变化各不相同.

  10. Effect of S. macrosiphon and L. perfoliatum seed gums on rheological characterization of bitter orange (Citrus aurantium L.) and pomegranate (Punica granatum L.) paste blends.

    Asnaashari, Maryam; Motamedzadegan, Ali; Farahmandfar, Reza; Rad, Tandis Khosravi

    2016-02-01

    The steady shear flow properties of bitter orange and pomegranate pastes and blend of two pastes including 0.5% Salvia macrosiphon (SMG) and L. perfoliatum (LPG) seed gums, two traditional Iranian hydrocolloids, were determined. All treatments exhibited shear-thinning behaviour. LPG added sample showed stronger shear thinning behaviour than the other due to its high molecular weight and intermolecular through hydrogen bonds and polymer entanglement. Ostwald model was found the best model to describe steady shear flow behaviour among different time-independent rheological model applied. Treatments including 0.5% these two seed gums indicated a flow behaviour index less than 0.6 and consistency coefficient raised by increasing concentration from 60 °Bx to 76 °Bx in bitter orange paste (from 0.55 Pa s(n) to 32.58 Pa s(n)), pomegranate paste (from 0.55 Pa s(n) to 84.87 Pa s(n)) and mix of these two pastes (from 0.64 Pa s(n) to 56.9 Pa s(n)). Oscillatory shear data showed weak gel-like behaviour of bitter orange and pomegranate pastes treatments including seed gums with the elastic modulus predominating over the viscous one at lower frequency. However, after weak gel formation, G″ was higher than G' in the frequency range of 0.01 to 10 Hz. An Ostwald model was used to describe the changes of viscose modulus with frequency. The results indicate that the elastic properties of bitter orange/ pomegranate paste and bitter orange paste may be increased by the presence of LPG and SMG due to associations of ordered chain segments of these gums, resulting in a weak three-dimensional network. PMID:27162409

  11. Antioxidant activity directed isolations form punica granatum

    The extracts derived from pomegranate juice following antioxidant activity directed isolation were screened for their antioxidant activity through their ability to scavenge 2,2- diphenyl-l-picrylhydrazyl (DPPH) radicals. Only fractions which exhibited >50/0 DPPH scavenging effect at each step of isolation were selected for further purification and their ability to reduce peroxide formation (peroxide value) in heated com oil. Phytochemical analysis of the pure compounds finally obtained, revealed the presence of pelargonidin-3- galactose (Pg-3-galactose), cyanidin-3-glucose (Cy-3-Glucose), gallic acid, quercetin and myricetin in the fractions exhibiting >50% DPPH scavenging potential. The order of antioxidant activity of these pure compounds by DPPH method was found to be gallic acid> quercetin> myricetin> Cy-3-galactose> Pg-3-Glucose while order with respect to reduction in peroxide value (PV) was the reverse of DPPH. (author)

  12. Antibacterial Activity of Punica granatum Linn.

    Kenan Tunç

    2013-08-01

    Full Text Available In this study, it was investigated that the extracts (ethanol, aceton, methanol, ethyl acetat obtained from fruit peels of the plant to whether has antibacterial effect against Streptococcus mitis CNCTC 4/77, Streptococcus salivarius CNCTC 64/59, Streptococcus mutans CNCTC 8/77, Staphylococcus epidermidis ATCC 12228, Staphylococcus aureus ATCC 29213, Escherichia coli ATCC 25922, Salmonella abony NCTC 6017, Salmonella typhimurium ATCC 14028, Enterococcus faecalis ATCC 29212, Bacillus subtilis ATCC 6633 bacteria strains in vitro. The antibacterial activity of extracts was evaluated according to disc diffusion method. It has been determined that pomegranate peel's extract had the highest inhibition zone diameters ( 18-30 mm against S. epidermidis and S. aureus bacteria strains. The antibacterial activity of plant against Streptococcus mitis is determined in this study for the first time.

  13. Estudo da ação antimicrobiana conjunta de extratos aquosos de Tansagem (Plantago major l., Plantaginaceae e Romã (Punica granatum l., Punicaceae e interferência dos mesmos na ação da amoxicilina in vitro

    D.G. Teles

    2014-01-01

    Full Text Available O uso de plantas medicinais no tratamento de doenças (fitoterapia é uma prática de diversos povos, sendo realizada desde a Antiguidade. Diversos estudos são realizados para determinar a eficácia dessas plantas, sendo desconhecida a existência de interações e interferências na combinação das mesmas, quer seja benéfica, quer cause algum dano para o organismo. A fim de descobrir a existência dessas interações ou a interferência na ação do antibiótico amoxicilina testou-se Punica granatum e Plantago major contra as bactérias Staphylococcus aureus e Escherichia coli. A matéria prima foi obtida nas regiões de Montes Claros e Curvelo e seus extratos aquosos foi obtido através da decocção. A Concentração Inibitória Mínima (CIM dos extratos foi determinada pela técnica de microdiluição em caldo. Para o teste de interferência realizou-se o teste de disco-difusão. No teste de microdiluição em caldo, Punica granatum apresentou CIM de 6,25% contra o S. aureus e de 25% contra E. coli. O extrato de Plantago major não apresentou atividade contra as bactérias. O teste de disco-difusão confirmou a existência de interações, sendo apenas quatro resultados significativos (Amoxicilina + Plantago major Pura (PgP, Amoxicilina + Plantago major Diluição 1 (PgD1 e Amoxicilia + Plantago major Diluição 2 (PgD2 contra E. coli e Amoxicilina + PgP contra S. aureus. Conclui-se que existe interação dos extratos entre si e dos extratos com a amoxicilina, o que também pode acontecer com outros antibióticos e gerar riscos para a população. Portanto é indispensável à realização de testes que complementem essa pesquisa oferecendo mais informação à população para segurança na utilização de plantas medicinais. informações à população assegurando sua segurança na utilização de plantas medicinais.

  14. Root activity distribution pattern of Ganesh pomegranate (Punica granatum) seedlings

    In one-year old Ganesh pomegranate seedlings raised on a loamy sand (Typic Haplustalf) under rain fed conditions, during winter (January-March) one-half of the active roots (44-51%) resided at 50 cm radial distance. Depth wise, bulk (44-78%) of the roots were found at 15 cm depth. The results indicate that the zone of high root activity is located around 50 cm distance from trunk and applications of fertilizers in this zone may lead to enhanced use efficiency of fertilizers. (author)

  15. Medicinal Uses of Punica Granatum And Its Health Benefits

    Debjit Bhowmik

    2013-01-01

    Full Text Available Pomegranate has been used for thousands of years to cure a wide range of diseases across different cultures and civilizations. It has great nutritional values and numerous health benefits. Pomegranates as a Treatment for Cancer, Osteoarthritis and Other Diseases. The pomegranate has been used in natural and holistic medicine to treat sore throats, coughs, urinary infections, digestive disorders, skin disorders, arthritis, and to expel tapeworms. However, modern research suggests that pomegranates might be useful in treating such serious conditions as prostate cancer, skin cancer, osteoarthritis, and diabetes. Studies also show that pomegranate seeds might help rid the digestive system of fats. Clinical research shows that pomegranates, when part of a healthy diet, might help prevent heart disease, heart attacks and strokes. This is because pomegranates have the potential to thin the blood, increase blood flow to the heart, reduce blood pressure, reduce plaque in the arteries, and reduce bad cholesterol while increasing good cholesterol. A decoction of seed is used to treat syphilis. Juice used to treat jaundice and diarrhoea. Juice of flower is used to treat nose bleeds. The fruit pulp and the seed are stomachic. Dried, pulverized flower buds are employed as a remedy for bronchitis.

  16. Medicinal Uses of Punica Granatum And Its Health Benefits

    Debjit Bhowmik; Harish Gopinath; B. Pragati Kumar; S.Duraivel; Aravind. G; K.P. Sampath Kumar

    2013-01-01

    Pomegranate has been used for thousands of years to cure a wide range of diseases across different cultures and civilizations. It has great nutritional values and numerous health benefits. Pomegranates as a Treatment for Cancer, Osteoarthritis and Other Diseases. The pomegranate has been used in natural and holistic medicine to treat sore throats, coughs, urinary infections, digestive disorders, skin disorders, arthritis, and to expel tapeworms. However, modern research suggests that pomegran...

  17. Ellagitannins of the fruit rind of pomegranate (Punica granatutm) antagonize in vitro the host inflammatory response mechanisms involved in the onset of malaria

    Bhattacharya Deepak; Romeo Sergio; Basilico Nicoletta; Bulgari Michela; Galli Germana V; Dell'Agli Mario; Taramelli Donatella; Bosisio Enrica

    2010-01-01

    Abstract Background The sun-dried rind of the immature fruit of pomegranate (Punica granatum) is presently used as a herbal formulation (OMARIA, Orissa Malaria Research Indigenous Attempt) in Orissa, India, for the therapy and prophylaxis of malaria. The pathogenesis of cerebral malaria, a complication of the infection by Plasmodium falciparum, is an inflammatory cytokine-driven disease associated to an up-regulation and activity of metalloproteinase-9 and to the increase of TNF production. T...

  18. КЛИНИКО-ЛАБОРАТОРНАЯ ОЦЕНКА ЭФФЕКТИВНОСТИ ГРАНАТОВОГО МАСЛА (PUNICA GRANATUM L.) В ЛЕЧЕНИИ ВОСПАЛИТЕЛЬНЫХ ЗАБОЛЕВАНИЙ ПАРОДОНТА

    ГАРАЕВ З.И.; АЛИЕВ А. А.

    2014-01-01

    В выборе лечебных манипуляций при воспалительных заболеваниях пародонта наиболее часто применяется профессиональная гигиена полости рта. При этом по мере отягощения воспалительного процесса в тканях пародонта наблюдается тенденция к снижению частоты ее применения. Хирургическое лечение чаще проводится при диагностировании пародонтита тяжелой степени. По результатам клинических и лабораторных исследований доказано выраженное противовоспалительное действие гранатового масла «Punica granatum». П...

  19. Comparative proteomics analysis of pomegranate seeds on fruit maturation period (Punica granatumL.)

    CAO Shang-yin; NIU Juan; CAO Da; LI Hao-xian; XUE Hui; CHEN Li-na; ZHANG Fu-hong; ZHAO Di-guang

    2015-01-01

    Seeds play a central role in the life cycle of plants. Seed hardness in pomegranates is of economic relevance, yet scarcely studied and poorly understood in China. In this study, we compared the proteomic differences between Zhong-nonghong (soft-seeded) and Sanbai (hard-seeded) pomegranates. A total of 892 protein spots from both varieties were detected on two-dimensional electrophoresis gels (2-DE); 76 spots showed greater than a 1.5-fold or less than a 0.66-fold difference (P<0.05) in Zhongnonghong compared to Sanbai, of which 24 exhibited greater than a 2-fold change. Compared with Sanbai, Zhongnonghong possessed 14 up-regulated, and 10 down-regulated proteins. We identiifed and annotated 5 of these by using MALDI-TOF-TOF MS: pyruvate dehydrogenase (PDH) E1-β family protein (spot 4609); alanine aminotransferase 2-like (ALT2L); mitochondrial glycine decarboxylase complex P-protein (spot 5803);phosphofructokinase B (PfkB)-type family of carbohydrate kinase (spot 8411); and putative dnaK-type molecular chaperone heat shock cognate protein 70 (Hsc70) (spot 9006). Of these, 3 proteins (spots 4609, 5608, 5803) were hypothesized to play a role in the formation of seed hardness. The other two proteins (spots 8411, 9006) were theo-rized to play a role in protecting the seeds from adverse stress during periods of fruit maturation. This study sets the foundation for further research on molecular mechanisms related to pomegranate seed hardness.

  20. CALLUS INDUCTION AND PLANT REGENERATION IN PUNICA GRANATUM L. ?NANA' FROM LEAF EXPLANTS

    Alireza Bonyanpour

    2013-09-01

    Full Text Available ABSTRACT In this investigation, leaf explants of a local cultivar of dwarf pomegranate were placed on Murashige and Skoog (1962 (MS medium supplemented with various concentrations of 6-benzyl adenin (BA and naphthalene acetic acid (NAA for callus induction. After 40 days, maximum callus induction was observed on a media containing 1 mg L-1 BA and 0.2 to 0.4 mg L-1 NAA. However, the highest callus growth was obtained on a medium containing 1 mg L-1 BA and 1 mg L-1 NAA. The highest number of shoots (7 shoots per explants was obtained by transferring the calli to the media containing 5 mg L-1 BA with 0.1 mg L-1 NAA. Maximum shoot proliferation was observed when shoots were cultured on woody plant medium (WPM supplemented with 5 mg L-1 kinetin (Kin. In this treatment, after 4 subcultures, 36 shoots were produced from one original explant. Among treatments used in rooting experiments, shoots cultured on WPM medium containing 0.2 mg L-1 indol butyric acid (IBA had the maximum root percentage (100% and good root growth (2.06 cm mean length and 2 roots in each explants. Rooted plantlets were cultured in a soil mixture containing vermiculite (60%, perlite (30% and coco peat (10% v/v. After 2 months, 80% of plants survived and transferred to the greenhouse.

  1. Evaluation of antioxidant and antiradical properties of Pomegranate (Punica granatum L.) seed and defatted seed extracts

    Basiri, Shadi

    2013-01-01

    Pomegranate seeds are byproducts of the Pomegranate juice industries that contains functional compounds such as phenols. This study was aimed to evaluate the effect of solvents on extraction from Pomegranate seed and Pomegranate defatted seed and to measure the yield extract and phenolic content and antioxidant properties. For this purpose, the seeds and defatted seeds were directly isolated from fruits and seeds by cold pressing respectively, then were crushed and extracted with different so...

  2. Spatial distribution of root activity of Ganesh pomegranate (Punica granatum) plants

    Information on the root activity pattern is invaluable while adopting appropriate time and method of fertilizer application, irrigation, planting distance and other cultural practices. The pattern of root activity distribution determined using the technique of soil injection of 32P compares well with actual pattern ascertained by root excavation method. The isotopic technique is also non-destructive, quick and inexpensive. Root activity distribution pattern has been determined using this technique in citrus, grape, mango, guava and papaya. To generate the information on inbred Ganesh pomegranate seedlings, studies were undertaken and the results are reported in this paper. (author)

  3. Molecular Polymorphisms in Tunisian Pomegranate (Punica granatum L. as Revealed by RAPD Fingerprints

    Jemni Chibani

    2010-01-01

    Full Text Available The genetic diversity among Tunisian pomegranate cultivars has been investigated. Using universal primers, the random amplified polymorphic DNA (RAPD method was used to generate banding profiles from a set of twelve cultivars. Data was then computed with appropriate programs to construct a dendrogram illustrating the relationships between the studied cultivars. Our data proved the efficiency of the designed method to examine the DNA polymorphism in this crop since the tested primers are characterized by a collective resolving power of 12.83. In addition, the cluster analysis has exhibited a parsimonious tree branching independent from the geographic origin of the cultivars. In spite of the relatively low number of primers and cultivars, RAPD constitutes an appropriate procedure to assess the genetic diversity and to survey the phylogenetic relationships in this crop.

  4. CALLUS INDUCTION AND PLANT REGENERATION IN PUNICA GRANATUM L. ?NANA' FROM LEAF EXPLANTS

    Alireza Bonyanpour; Morteza Khosh-Khui

    2013-01-01

    ABSTRACT In this investigation, leaf explants of a local cultivar of dwarf pomegranate were placed on Murashige and Skoog (1962) (MS) medium supplemented with various concentrations of 6-benzyl adenin (BA) and naphthalene acetic acid (NAA) for callus induction. After 40 days, maximum callus induction was observed on a media containing 1 mg L-1 BA and 0.2 to 0.4 mg L-1 NAA. However, the highest callus growth was obtained on a medium containing 1 mg L-1 BA and 1 mg L-1 NAA. The highest number o...

  5. Bioactive properties of commercialised pomegranate (Punica granatum) juice: antioxidant, antiproliferative and enzyme inhibiting activities.

    Les, Francisco; Prieto, Jose M; Arbonés-Mainar, Jose Miguel; Valero, Marta Sofía; López, Víctor

    2015-06-01

    Pomegranate juice and related products have long been used either in traditional medicine or as nutritional supplements claiming beneficial effects. Although there are several studies on this food plant, only a few studies have been performed with pomegranate juice or marketed products. The aim of this work is to evaluate the antioxidant effects of pomegranate juice on cellular models using hydrogen peroxide as an oxidizing agent or DPPH and superoxide radicals in cell free systems. The antiproliferative effects of the juice were measured on HeLa and PC-3 cells by the MTT assay and pharmacologically relevant enzymes (cyclooxygenases, xanthine oxidase, acetylcholinesterase and monoamine oxidase A) were selected for enzymatic inhibition assays. Pomegranate juice showed significant protective effects against hydrogen peroxide induced toxicity in the Artemia salina and HepG2 models; these effects may be attributed to radical scavenging properties of pomegranate as the juice was able to reduce DPPH and superoxide radicals. Moderate antiproliferative activities in HeLa and PC-3 cancer cells were observed. However, pomegranate juice was also able to inhibit COX-2 and MAO-A enzymes. This study reveals some mechanisms by which pomegranate juice may have interesting and beneficial effects in human health. PMID:26030005

  6. Molecular Polymorphisms in Tunisian Pomegranate (Punica granatum L.) as Revealed by RAPD Fingerprints

    Jemni Chibani; Mokhtar Trifi; Messaoud Mars; Néjib Hasnaoui

    2010-01-01

    The genetic diversity among Tunisian pomegranate cultivars has been investigated. Using universal primers, the random amplified polymorphic DNA (RAPD) method was used to generate banding profiles from a set of twelve cultivars. Data was then computed with appropriate programs to construct a dendrogram illustrating the relationships between the studied cultivars. Our data proved the efficiency of the designed method to examine the DNA polymorphism in this crop since the tested primers are char...

  7. The arils characterization of five different pomegranate (Punica granatum) genotypes stored after minimal processing technology.

    Ghasemnezhad, Mahmood; Zareh, Somayeh; Shiri, Mohammad Ali; Javdani, Zahra

    2015-04-01

    In this study, the quality of minimally processed different Iranian pomegranate genotypes was investigated during storage at 4 °C for 14 days. The results showed that at the end of storage time, the lowest microbial count was found on the arils of "Torsh Syabe Lorestan" genotype. There was a significant difference in titratable acidity, total soluble solids, total anthocyanin, catechin, and quercetin content in most genotypes after 14-day cold storage; while no difference was found between studied genotypes in antioxidant capacity, total phenolic, and flavonoid content. In general, total phenolic content and antioxidant capacity of pomegranate arils gradually decreased over storage time. Diphenolase activity of polyphenol oxidase (PPO) enzyme with dopamine hydrochloride substrate and peroxidase (POD) decreased over storage time, whereas diphenolase activity of PPO with pyrocatechol substrate significantly increased. The lowest diphenolase activity with dopamine hydrochloride and pyrocatechol substrates, as well as POD activity was found in Torsh Syabe Lorestan. The results suggested that the genotype of Torsh Syabe Lorestan, which showed the lowest microbial count on the arils and enzymes, could be more appropriate for minimal processing technology. PMID:25829582

  8. Punica granatum: A review on its potential role in treating periodontal disease

    Prasad, Divyashree; Kunnaiah, Ravi

    2014-01-01

    A wide variety of plants possess enormous treasure of medicinal value. Majority of these medicinal plants have been used to treat various systemic conditions successfully. Over the recent years, use of these medicinal plants has resurfaced to treat oral conditions. Among the oral conditions, periodontal disease remains one of the most common. Alternative and preventive options has become the need of the hour in order to overcome the adverse effects of the antimicrobial agents used in large as...

  9. Evaluation of antioxidant and antiradical properties of Pomegranate (Punica granatum L.) seed and defatted seed extracts.

    Basiri, Shadi

    2015-02-01

    Pomegranate seeds are byproducts of the Pomegranate juice industries that contains functional compounds such as phenols. This study was aimed to evaluate the effect of solvents on extraction from Pomegranate seed and Pomegranate defatted seed and to measure the yield extract and phenolic content and antioxidant properties. For this purpose, the seeds and defatted seeds were directly isolated from fruits and seeds by cold pressing respectively, then were crushed and extracted with different solvents, including water, Methanol, Acetone, Ethyl acetate and Hexane and finally the extracts of them were evaluted. Phenolic compounds, ferric reducing-antioxidant power and radicals scavenging property of extracts were measured. The results showed the highest extraction efficiencies were for Hexane and Acetone solvents in extraction of seed and defatted seed respectively. The highest phenolic content was obtained from Methanol seed extract. Reducing activity test proved that the Methanol extracts of Pomegranate seed and Pomegranate defatted seed had the highest reducing strength. Results of radical scavenging activity were similar to reducing activity results. The order of antioxidant capacity of Pomegranate seed and Pomegranate defatted seed were found to be Methanol > Water > Acetone > Butanol > Ethyl acetate > Hexane. It can be concluded Pomegranate seed, which possesses high levels of polyphenols, can be one of the sources of the natural antioxidants. The Methanol extract had a higher antioxidant efficiency than seed and defatted seed extracts. PMID:25694727

  10. Pomegranate juice (punica granatum: a new storage medium for avulsed teeth.

    Sara Tavassoli-Hojjati

    2014-04-01

    Full Text Available There is evidence indicating that pomegranate juice contains many of the essential properties necessary to retain cell viability and cell proliferation. These properties indicate that pomegranate juice is a suitable storage medium for avulsed teeth. However, this idea has not yet been tested. In this study, the capacity of pomegranate juice (PJ as a storage medium for retaining avulsed teeth was evaluated.PDL fibroblasts were obtained from healthy human premolars and cultured in Dulbecco's Modified Eagle's Medium (DMEM. Cultured cells were subjected to different concentrations of pomegranate juice (PJ, 1% Hank's balanced salt solution (HBSS and tap water for 1, 3, 6 and 24 hours. PDL cell viability was assessed by the neutral red uptake assay.The results indicated that 7.5% PJ was the most effective solution for maintaining PDL cell viability amongst all the experimental solution's and time intervals (P<0.05. The results also showed that 1% PJ was as effective as HBSS for maintaining PDL cell viability. The amount of cell viability increased with increasing concentration of PJ at all time intervals (P<0.001. This effect is suggestive of the proliferative potential of PJ solution.In conclusion, PJ can be recommended as a suitable transport medium for avulsed teeth.

  11. Bioactive properties of commercialised pomegranate (Punica granatum) juice: antioxidant, antiproliferative and enzyme inhibiting activities

    Les, F.; Prieto, J.M.; Arbonés-Mainar, J. M.; Valero, M. S.; López, V.

    2015-01-01

    Pomegranate juice and related products have long been used either in traditional medicine or as nutritional supplements claiming beneficial effects. Although there are several studies on this food plant, only a few studies have been performed with pomegranate juice or marketed products. The aim of this work is to evaluate the antioxidant effects of pomegranate juice on cellular models using hydrogen peroxide as an oxidizing agent or DPPH and superoxide radicals in cell free systems. The antip...

  12. Punica granatum (Pomegranate juice provides an HIV-1 entry inhibitor and candidate topical microbicide

    Li Yun-Yao

    2004-10-01

    Full Text Available Abstract Background For ≈ 24 years the AIDS pandemic has claimed ≈ 30 million lives, causing ≈ 14,000 new HIV-1 infections daily worldwide in 2003. About 80% of infections occur by heterosexual transmission. In the absence of vaccines, topical microbicides, expected to block virus transmission, offer hope for controlling the pandemic. Antiretroviral chemotherapeutics have decreased AIDS mortality in industrialized countries, but only minimally in developing countries. To prevent an analogous dichotomy, microbicides should be: acceptable; accessible; affordable; and accelerative in transition from development to marketing. Already marketed pharmaceutical excipients or foods, with established safety records and adequate anti-HIV-1 activity, may provide this option. Methods Fruit juices were screened for inhibitory activity against HIV-1 IIIB using CD4 and CXCR4 as cell receptors. The best juice was tested for inhibition of: (1 infection by HIV-1 BaL, utilizing CCR5 as the cellular coreceptor; and (2 binding of gp120 IIIB and gp120 BaL, respectively, to CXCR4 and CCR5. To remove most colored juice components, the adsorption of the effective ingredient(s to dispersible excipients and other foods was investigated. A selected complex was assayed for inhibition of infection by primary HIV-1 isolates. Results HIV-1 entry inhibitors from pomegranate juice adsorb onto corn starch. The resulting complex blocks virus binding to CD4 and CXCR4/CCR5 and inhibits infection by primary virus clades A to G and group O. Conclusion These results suggest the possibility of producing an anti-HIV-1 microbicide from inexpensive, widely available sources, whose safety has been established throughout centuries, provided that its quality is adequately standardized and monitored.

  13. Pomegranate juice (punica granatum): a new storage medium for avulsed teeth.

    Sara Tavassoli-Hojjati; Elham Aliasghar; Fatemeh Ahmadian Babaki; Fatemeh Emadi; Maliheh Parsa; Shohreh Tavajohi; Maryam Ahmadyar; Seyed Nasser Ostad

    2014-01-01

    Objective There is evidence indicating that pomegranate juice contains many of the essential properties necessary to retain cell viability and cell proliferation. These properties indicate that pomegranate juice is a suitable storage medium for avulsed teeth. However, this idea has not yet been tested. In this study, the capacity of pomegranate juice (PJ) as a storage medium for retaining avulsed teeth was evaluated. Materials and Methods: PDL fibroblasts were obtained from healthy human prem...

  14. Correlation between the morphological characters of pomegranate (Punica granatum) traits and their implications for breeding

    Karimi, Hamid Reza; MIRDEHGHAN, Seyed Hossein

    2013-01-01

    Pomegranate is one of the most important horticultural crops in Iran. Selection of suitable genotypes resistant to unfavourable environmental and soil conditions and diseases is important for increasing the yield efficiency and acreage of this important crop. The aim of this research was to compare commercial pomegranate genotypes in Iran and to determine any correlations between morphological characteristics. Eight pomegranate types were used during the research. Twenty-six morphological cha...

  15. Optimization of ultrasonic-assisted extraction of pomegranate (Punica granatum L.) seed oil.

    Tian, Yuting; Xu, Zhenbo; Zheng, Baodong; Martin Lo, Y

    2013-01-01

    The effectiveness of ultrasonic-assisted extraction (UAE) of pomegranate seed oil (PSO) was evaluated using a variety of solvents. Petroleum ether was the most effective for oil extraction, followed by n-hexane, ethyl acetate, diethyl ether, acetone, and isopropanol. Several variables, such as ultrasonic power, extraction temperature, extraction time, and the ratio of solvent volume and seed weight (S/S ratio) were studied for optimization using response surface methodology (RSM). The highest oil yield, 25.11% (w/w), was obtained using petroleum ether under optimal conditions for ultrasonic power, extraction temperature, extraction time, and S/S ratio at 140 W, 40 °C, 36 min, and 10 ml/g, respectively. The PSO yield extracted by UAE was significantly higher than by using Soxhlet extraction (SE; 20.50%) and supercriti cal fluid extraction (SFE; 15.72%). The fatty acid compositions were significantly different among the PSO extracted by Soxhlet extraction, SFE, and UAE, with punicic acid (>65%) being the most dominant using UAE. PMID:22964031

  16. Characterization of constituents, quality and stability of pomegranate seed oil (Punica granatum L.

    Illana Louise Pereira de MELO

    2016-03-01

    Full Text Available Abstract This study aimed to characterize pomegranate seed oil and evaluate its quality and stability parameters against those of linseed oil. The profile of fatty acids and phytosterols and the content of tocopherols were analyzed by gas chromatography and high performance liquid chromatography, respectively. The quality of both oils was assessed as recommended by the American Oil Chemists' Society (AOCS and stability was evaluated using 2,2-diphenyl-1-picrylhydrazyl (DPPH, β-carotene bleaching (coupled oxidation of β-carotene/linoleic acid and Rancimat® assays. While α-linolenic acid (52% was the most abundant fatty acid in linseed oil (LO, punicic acid (55% was highest in pomegranate seed oil (PSO. Tocopherols and phytosterols (175 and 539 mg/100 g, respectively were greater in PSO than in LO (51 and 328 mg/100 g, respectively. Both oils met quality standards. The β-carotene bleaching and the DPPH assays showed greater oxidative stability for PSO than for LO. The Rancimat® method, on the other hand, indicated low stability for both oils.

  17. Pomegranate juice (Punica granatum as an ideal mouthrinse for fixed orthodontic patients

    Haryono Utomo

    2012-12-01

    Full Text Available Background: Prevention of caries as well as periodontal disease is mandatory during orthodontic treatment. Nevertheless, the use of antiseptic mouthrinse is contraindicated for prolonged use. Pomegranate juice is a polyphenol-rich juice with high antioxidant capacity as well as antimicrobial properties. It has been shown to exert beneficial characteristics for orthodontic patients such as antioxidant and anti inflammatory effects. Moreover, it contained fluoride and phosphorous which are cariostatic. Previous study in fixed orthodontic patients revealed that rinsing with this juice showed reduced dental plaque and superior compared with chlorhexidine. If it has unwanted effect by reducing pro-inflammatory reaction that also needed in orthodontic movement is not clearly understood. Purpose: The aim of the present review was to discuss the beneficial and unwanted effect of pomegranate juice mouthrinse towards orthodontic treatment. Reviews: Pomegranate has antimicrobial activity, its methanolic skin extract is the most potent followed by seed juice. Nevertheless, seed juice is not only tastier, easier to make but also has mild antimicrobial potency which is beneficial for long-term use. Healthy periodontal tissue is preferable for orthodontic movement since it resulted in less unwanted bone resorption. Conclusion: Regarding its beneficial effect and safety of pomegranate juice if use daily mouthrinse in fixed orthodontic patients, it could be proposed as an ideal long term use mouthrinse for fixed orthodontic patients. However, further researches should be done to verify this concept.Latar belakang: Pencegahan karies dan penyakit periodontal sangat penting dalam perawatan ortodontik. Walaupun demikian, penggunaan obat kumur antiseptik jangka panjang merupakan kontraindikasi. Jus buah delima sangat kaya akan polifenol dengan kemampuan antioksidan yang tinggi disertai kemampuan antimikroba. Beberapa penelitian telah menunjukkan dampak menguntungkan pada pasien ortodonti, yaitu sebagai antioksidan dan anti radang. Selain itu juga mengandung fluor dan fosfor yang bersifat kariostatik. Penelitian terdahulu pada pasien ortodonti cekat menunjukkan penurunan plak gigi yang lebih banyak dibanding dengan klorheksidin. Akan tetapi, apakah juga menyebabkan dampak merugikan yaitu mengurangi reaksi keradangan yang juga penting bagi pergerakan ortodonti masih belum jelas. Tujuan: Membahas dampak menguntungkan maupun merugikan jus buah delima pada perawatan ortodonti. Tinjauan pustaka: Buah delima merupakan antimikroba, ekstrak dari kulit yang mengandung metanol adalah paling kuat diikuti jus biji delima. Akan tetapi, jus biji lebih enak rasanya, mudah dibuat dan merupakan antimikroba ringan sehingga menguntungkan untuk pemakaian jangka panjang. Jaringan periodontal yang sehat diperlukan untuk pergerakan ortodonti karena dapat mengurangi resorpsi tulang. Kesimpulan: Berdasarkan dampak menguntungkan dan keamanan jus buah delima bila digunakan tiap hari, bahan ini dapat diusulkan sebagai obat kumur jangka panjang yang ideal untuk pasien ortodonti cekat. Walaupun begitu, penelitian lebih lanjut harus dilakukan untuk verifikasi konsep ini.

  18. In vitro propagation of pomegranate (Punica granatum l.) Cv. ‘Males Yazdi’

    Babak Valizadeh Kaji; Ahmad Ershadi; Masoud Tohidfar

    2013-01-01

    Conventional method of propagation of pomegranate is time consuming and tiresome, and it does not ensure disease free and healthy plants. In vitro technique is the only prospect of plant tissue culture that has the potential to circumvent these problems. An efficient in vitro propagation is described for pomegranate using shoot tips and nodal explants. The influence of two basal medium, WPM and MS, and different plant growth regulators was investigated on micropropagation of the Iranian culti...

  19. Antimicrobial Analysis of an Antiseptic Made from Ethanol Crude Extracts of P. granatum and E. uniflora in Wistar Rats against Staphylococcus aureus and Staphylococcus epidermidis

    Thaís Honório Lins Bernardo

    2015-01-01

    Full Text Available Introduction. Surgical site infection remains a challenge for hospital infection control, especially when it relates to skin antisepsis in the surgical site. Objective. To analyze the antimicrobial activity in vivo of an antiseptic from ethanol crude extracts of P. granatum and E. uniflora against Gram-positive and Gram-negative bacteria. Methods. Agar drilling and minimal inhibitory tests were conducted for in vitro evaluation. In the in vivo bioassay were used Wistar rats and Staphylococcus aureus (ATCC 25923 and Staphylococcus epidermidis (ATCC 14990. Statistical analysis was performed through variance analysis and Scott-Knott cluster test at 5% probability and significance level. Results. In the in vitro, ethanolic extracts of Punica granatum and Eugenia uniflora and their combination showed the best antimicrobial potential against S. epidermidis and S. aureus. In the in vivo bioassay against S. epidermidis, there was no statistically significant difference between the tested product and the patterns used after five minutes of applying the product. Conclusion. The results indicate that the originated product is an antiseptic alternative source against S. epidermidis compared to chlorhexidine gluconate. It is suggested that further researches are to be conducted in different concentrations of the test product, evaluating its effectiveness and operational costs.

  20. Optimization of Callua Induction Conditions of Vitro Leaves from Soft-seed Punica granatm L.%软籽石榴离体叶片愈伤组织诱导条件的优化

    彭丽萍; 郑雷

    2011-01-01

    [目的]研究软籽石榴离体叶片愈伤组织诱导的最佳条件.[方法]以软籽石榴的幼嫩叶片为外植体,以MS为基本培养基,研究了不同浓度和类型的植物生长调节剂、叶片的不同部分、不同糖浓度和类型对愈伤组织诱导的影响.[结果]培养基MS+0.1 mg/LNAA+0.1 mg/L IBA+1.0 mg/L6-BA+30 g/L蔗糖对愈伤组织的诱导效果最好,选择叶片中部或叶片基部为外植体,可以有效提高诱导率,降低褐化率,诱导率最高达93.3%,褐化率最低达23.3%.[结论]为石榴的离体快繁、种质保存和利用基因工程技术改良品质奠定一定的理论和实践基础.%[ Objective] The aim was to study the best conditions of callus induction conditions of vitro leaves from soft-secd Punica granatum L. [ Method ] The vitro leaves of soft-seed Punica granatum L. was as explant, MS was basic medium. Effect of different concentrations and types of hormone , different parts of the leaves and different sugar concentration and types on callus induction were studyed. [ Result ] The results showed that the medium MS + 0. 1 mg/L/NAA + 0. 1 mg/L IBA + 1.0 mg/L 6-BA + 30 g/L sucrose was best for callus induction, the base or midcdle of leaves(including part of petiole) was as explant 1,lt could improve callus rate and reduce browning rate. [ Conclusion]The study provided theory and practice basic for callus induction, germinal conversation and improving quality. of soft-seed Punica granatum L

  1. Resources of Punica granatum Linn. and Its Exploitation and Utilization in Xinjiang%新疆石榴(Punica L.)资源及其开发利用

    刘文江

    2007-01-01

    石榴作为新疆一种绿色食品资源,受到国内外市场广泛关注,使得新疆近几年石榴的种植面积迅速扩大.本文对新疆石榴生物学特性、种类、品种和开发利用价值等方面进行了详细论述,阐明了新疆大力发展石榴产业的优势,并在分析现状和存在问题的基础上,提出了新疆发展石榴产业的几点建议.

  2. Genetic diversity of pomegranate (Punica granatum L.) population in China by RAMP markers%中国石榴(Punica granatum L.)居群遗传多样性

    赵丽华

    2013-01-01

    为了更有效地保护和利用石榴种质资源,利用RAMP标记对中国7个石榴主产区的46个石榴品种进行遗传分析.结果显示:14对RAMP引物共扩出127条DNA条带,其中113条显示多态性,多态位点百分率(P)为88.98%;7个石榴居群遗传多样性依次为:山东居群>陕西居群>云南居群>河南居群>安徽居群>四川居群>新疆居群;7个居群间的基因分化系数(Gst)为0.183 0;群间基因流的估测值(Nm)为2.231 5.表明中国石榴具有较大的遗传变异及丰富的遗传多样性,居群间存在较强的基因流.%To protect and utilize pomegranate resources in China,random amplified microsatellite polymorphism (RAMP) technique was used to analyze the genetic relationships among 46 pomegranate genotypes collected from seven major production areas in China.A total of 127 bands were amplified by fourteen pairs of high polymorphism primers,among which 113 (88.98%) were polymorphic loci.The genetic diversity of seven pomegranate populations followed the order of Shandong > Shannxi > Yunnan > Henan > Anhui > Sichuan > Xinjiang.The gene differentiation coefficient (Gst) of seven populations was 0.183 0,and the gene flow (Nm) was 2.231 5.These statistics indicated that the present pomegranate resources in China had high genetic variation and genetic diversity,and a strong gene flow existed among these populations.

  3. Study on the Mechanism of Browning of Pomegranate (Punica granatum L.cv. Ganesh) Peel in Different Storage Conditions

    2008-01-01

    Peel browning of pomegranate fruit is the key problem during storage. The mechanism of it during storage in relation to the technology of the browning control was studied in this paper. The effects of storage temperature, gas component and Ph value on peel browning of sweet pomegranate fruit in Lintong, Shaanxi Province, China, were investigated. Change in tannin content was measured and the relationship between the activities of ascorbic acid oxidase (AAO), polypenoloxidase (PPO), peroxidase (POD), catalase (CAT) and peel browning was analysed. The results showed tannin was the basic substance of pomegranate peel browning. The activities of the browning index of peel were correlated positively with AAO, PPO and POD, correlated negatively with CAT activity. Application of intermittent warming for 24 h at (15 ±0.5)℃ every 5 days for pomegranate fruit storage under the conditions of Ph 4.0, (5.0 ± 0.5)℃ and 5.0% CO2 + 8.0% O2 +87.0% N2 gas component could delay browning, with the browning index being 0.15 after 120 days of storage. Enzymatic tannin denaturation was the main cause that led to peel browning of pomegranate fruit during storage. The browning control of pomegranate fruit peel was effective using intermittent warming storage with suitable Ph, temperature and gas component.

  4. High-capacity calcium-binding chitinase III from pomegranate seeds (Punica granatum Linn.) is located in amyloplasts

    Lv, Chenyan; Masuda, Taro; Yang, Haixia; Sun, Lei; Zhao, Guanghua

    2011-01-01

    We have recently identified a new class III chitinase from pomegranate seeds (PSC). Interestingly, this new chitinase naturally binds calcium ions with high capacity and low affinity, suggesting that PSC is a Ca-storage protein. Analysis of the amino acid sequence showed that this enzyme is rich in acidic amino acid residues, especially Asp, which are responsible for calcium binding. Different from other known chitinases, PSC is located in the stroma of amyloplasts in pomegranate seeds. Trans...

  5. Irradiation Effect on the antioxidant properties, anti-microbial and cytoprotective of the bark of Punica granatum

    The bark of pomegranate has been used for some years to treat various health problems . Several studies have focused on specifying these problems, including antibacterial , antioxidant and cytoprotective . The use of pomegranate rind powder is an effective treatment against gastric ulcer and intestines and to strengthen the wall of the gastrointestinal tract. In this work, we studied the effects of gamma irradiation on the type antibacterial, anti-ulcer and bark grenade. This study was conducted on powdered pomegranate bark irradiated by applying decreasing radiation doses from 25kGy to 1.25KGy. All of our results shows that irradiation with a low degree improves the effectiveness of pomegranate bark for the treatment of gastric ulcer , however high degree irradiation enhances the antibacterial activity of bark pomegranate against Staphylococcus aureus.

  6. Preparation and antibacterial activities of Ag/Ag+/Ag3+ nanoparticle composites made by pomegranate (Punica granatum) rind extract

    Yang, Hui; Ren, Yan-yu; Wang, Tao; Wang, Chuang

    Nano-silver and its composite materials are widely used in medicine, food and other industries due to their strong conductivity, size effect and other special performances. So far, more microbial researches have been applied, but a plant method is rarely reported. In order to open up a new way to prepare AgNP composites, pomegranate peel extract was used in this work to reduce Ag+ to prepare Ag/Ag+/Ag3+ nanoparticle composites. UV-Vis was employed to detect and track the reduction of Ag+ and the forming process of AgNPs. The composition, structure and size of the crystal were analyzed by XRD and TEM. Results showed that, under mild conditions, pomegranate peel extract reacted with dilute AgNO3 solution to produce Ag/Ag+/Ag3+ nanoparticle composites. At pH = 8 and 10 mmol/L of AgNO3 concentration, the size of the achieved composites ranged between 15 and 35 nm with spherical shapes and good crystallinity. The bactericidal experiment indicated that the prepared Ag/Ag+/Ag3+ nanoparticles had strong antibacterial activity against gram positive bacteria and gram negative bacteria. FTIR analysis revealed that biological macromolecules with groups of sbnd NH2, sbnd OH, and others were distributed on the surface of the newly synthesized Ag/Ag+/Ag3+ nanoparticles. This provided a useful clue to further study the AgNP biosynthesis mechanism.

  7. Facile synthesis of size-tunable gold nanoparticles by pomegranate (Punica granatum) leaf extract: Applications in arsenate sensing

    Highlights: ► Pomegranate leaf extracts mediated rapid gold nanoparticle (AuNP) synthesis. ► The phyto-inspired AuNPs were size-tuned and characterized. ► The reducing and capping agents in the extract were identified. ► The nanoparticles reacted specifically with arsenate (V) ions. - Abstract: When pomegranate leaf extracts were incubated with chloroauric acid (HAuCl4), gold nanoparticles (AuNPs) were synthesized. These were characterized by a variety of techniques. With an increasing content of the leaf extract, a gradual decrease in size and an increase in monodispersity were observed. Transmission electron microscope (TEM) images showed that the phyto-fabricated AuNPs were surrounded by an amorphous layer. Gallic acid in the extract mediated the reduction and a natural decapeptide capped the nanostructures. Blocking of thiol groups in the decapeptide cysteine residues caused the nanoparticles to aggregate. On interaction with arsenate (V) ions, the UV–vis spectra of the nanoparticles showed a decrease in intensity and a red-shift. Energy dispersive spectra confirmed the presence of arsenate associated with the AuNPs. Thus, by using these AuNPs, a method for sensing the toxic arsenate ions could be developed

  8. Evaluation of pomegranate rind (Punica granatum hydroethanolic extract on blood parameters in male mice treated by Irinotecan Hcl

    N Mirazi

    2015-05-01

    Full Text Available Background & aim: Irinotecan Hcl is the first order drug for some neoplasm treatment in patients. Irinotecan Hcl has side effects on blood such as anemia and leukopeny. The aim of this study was to evaluate erythropoetic effects of the pomegranate hydroethanolic extract were examined on mice which treated by irinotecan Hcl. Methods: In this experimental study, 49 male mice (25-30 g were divided in 7 groups (control, sham, treated by irinotecan Hcl (100 mg/kg, treated by pomegranate extract (100 and 400 mg/kg, i.p, daily for one week and treated by irinotecan Hcl plus pomegranate extract (100 and 400 mg/kg, i.p, daily for one week randomly. Anemia induced by administration of irinotecan in the experimental animal. At the end of experiment the blood samples were collected by cardiac puncture method and analized for RBC, WBC, Hb, Hct parameters. Data were analyzed using one-way ANOVA and Tukey’s test. Results: The results of this study showed that irinotecan has affected on blood factors and cause to significance decrese compared with control group (p<0.001. Also groups which treated with pomegranate extract (100 and 400 mg/kg significantly reduce the side effects of irinotecan and cause to increasing in blood factors (p<0.001. The number of WBC counts in the group which received Irinotecan (100 kg significantly decreased as compared with the control group (p<0.001. Irinotecan affected on blood Hb level and cause to significant decrease compared with control group. Groups which received pomegranate extract (100 and 400 kg had positive effect and significantly increased the blood Hb levels as compared to controls (p<0.001. Conclusion: These results showed that consumption of pomegranate rind extract in a dose-dependent manner has protective effect on blood parameters in mice which treated with Irinotecan Hcl.

  9. Physicochemical properties and aroma volatile profiles in a diverse collection of California-grown pomegranate (Punica granatum L.) germplasm

    There are thousands of pomegranate accessions and more than 500 known pomegranate cultivars with around 50 available commercially, exhibiting different growing characteristics and quality attributes; such as fruit size, color, shape, seed hardness, taste and flavor traits which are sometimes not wel...

  10. Facile synthesis of size-tunable gold nanoparticles by pomegranate (Punica granatum) leaf extract: Applications in arsenate sensing

    Rao, Ashit; Mahajan, Ketakee; Bankar, Ashok [Institute of Bioinformatics and Biotechnology, University of Pune, Pune 411007 (India); Srikanth, Rapole [Proteomics Laboratory, National Centre for Cell Science, Pune 411007 (India); Kumar, Ameeta Ravi [Institute of Bioinformatics and Biotechnology, University of Pune, Pune 411007 (India); Gosavi, Suresh, E-mail: swg@physics.unipune.ac.in [Department of Physics, University of Pune, Pune 411007 (India); Centre for Sensor Studies, University of Pune, Pune 411007 (India); Zinjarde, Smita, E-mail: smita@unipune.ac.in [Institute of Bioinformatics and Biotechnology, University of Pune, Pune 411007 (India); Centre for Sensor Studies, University of Pune, Pune 411007 (India)

    2013-03-15

    Highlights: ► Pomegranate leaf extracts mediated rapid gold nanoparticle (AuNP) synthesis. ► The phyto-inspired AuNPs were size-tuned and characterized. ► The reducing and capping agents in the extract were identified. ► The nanoparticles reacted specifically with arsenate (V) ions. - Abstract: When pomegranate leaf extracts were incubated with chloroauric acid (HAuCl{sub 4}), gold nanoparticles (AuNPs) were synthesized. These were characterized by a variety of techniques. With an increasing content of the leaf extract, a gradual decrease in size and an increase in monodispersity were observed. Transmission electron microscope (TEM) images showed that the phyto-fabricated AuNPs were surrounded by an amorphous layer. Gallic acid in the extract mediated the reduction and a natural decapeptide capped the nanostructures. Blocking of thiol groups in the decapeptide cysteine residues caused the nanoparticles to aggregate. On interaction with arsenate (V) ions, the UV–vis spectra of the nanoparticles showed a decrease in intensity and a red-shift. Energy dispersive spectra confirmed the presence of arsenate associated with the AuNPs. Thus, by using these AuNPs, a method for sensing the toxic arsenate ions could be developed.

  11. The potential role of Punica granatum treatment on murine malaria-induced hepatic injury and oxidative stress.

    Hafiz, Taghreed A; Mubaraki, Murad A; Al-Quraishy, Saleh; Dkhil, Mohamed A

    2016-04-01

    Malaria is a health burden disease where the world harnessed the power of expertise and innovation to understand the biology of the parasite and the pathogenesis of the disease as well as to discover effective drugs. However, the treatment of malaria remains a challenging task and inadequate to address today's perplexing problem, the emergence of resistant strains. Historically, traditional medicine has been a mainstay for remediation and still retains its importance with the presence of potent natural products. Pomegranate has been used as antioxidant and anti-inflammatory against a range of diseases. Therefore, pomegranate peel extract (PPE) was used in this study to examine its effect on Plasmodium chabaudi-induced hepatic inflammation. Animals were allocated into three groups: a vehicle control group, a group infected with 10(6) P. chabaudi-parasitized erythrocytes and a pomegranate-treated group infected with 10(6) P. chabaudi-parasitized erythrocytes. This group received 100 μl of 300 mg/kg PPE after infection. The results showed the effectiveness of PPE on reversing the anaemic signs that have been provoked by P. chabaudi infection through instating the haemoglobin concentration and erythrocyte count back to normal values. Moreover, PPE exhibited hepatoprotective activities upon histopathological examination and liver function tests. These data were further confirmed by the significant reduction of the hepatic oxidative markers, glutathione, nitric oxide and malondialdehyde, in mice infected with P. chabaudi. Based on these outcomes, pomegranate could be used as a hepatoprotective agent against P. chabaudi-induced hepatic injury. However, further studies are needed in order to determine the mode of action of pomegranate upon infection. PMID:26670312

  12. Antioxidant and Anti-Inflammatory Activities of Pomegranate (Punica granatum) on Eimeria papillata-Induced Infection in Mice

    Amer, Omar S. O.; Dkhil, Mohamed A; Wafaa M. Hikal; Saleh Al-Quraishy

    2015-01-01

    Coccidiosis is the most prevalent disease causing widespread economic loss, especially in poultry farms. Here, we investigated the effects of pomegranate peel extract (PPE) on the outcome of coccidiosis caused by Eimeria papillata in mice. The data showed that mice infected with E. papillata and treated with PPE revealed a significant decrease in the output of oocysts in their faeces by day 5 p.i. Infection also induced inflammation and injury of the jejunum. This was evidenced (i) as increas...

  13. The effect of two methods of pomegranate (Punica granatum L) juice extraction on quality during storage at 4 degrees C

    Miguel Graça; Dandlen Susana; Antunes Dulce; Neves Alcinda; Martins Denise

    2004-01-01

    The effect of two extraction methods of pomegranate juice on its quality and stability was evaluated. The first method consisted of separation of the seeds from fruits and centrifugation. The second method consisted of squeezing fruit halves with an electric lemon squeezer. During a period of 72 hours of cold storage at 4 ∘ C, the juices were evaluated for the presence of sugars, organic acids, and anthocyanins. Delphinidin 3-glucoside was identified to be the major anthoc...

  14. Effect of different coatings on post-harvest quality and bioactive compounds of pomegranate (Punica granatum L.) fruits.

    Meighani, Hossein; Ghasemnezhad, Mahmood; Bakhshi, Davood

    2015-07-01

    The effect of three different coatings; resin wax (Britex Ti), carnauba wax (Xedasol M14), and chitosan (1 and 2 % w/v) on postharvest quality of pomegranate fruits were investigated. Fruits quality characteristics and bioactive compounds were evaluated during 40, 80 and 120 days storage at 4.5 °C and 3 additional days at 20 °C. The results showed that uncoated fruits showed higher respiration rate, weight loss, L* and b* values of arils, total soluble solids (TSS)/titratable acidity (TA), and pH than coated fruits during storage. Coating treatments could delay declining TSS and TA percent, a* value of arils, as well as bioactive compounds such as total phenolics, flavonoids and anthocyanins content and antioxidant activity. The coated fruits with commercial resin and carnauba waxes showed significantly lower respiration rate and weight loss than other treatments, however carnauba wax could maintain considerably higher fruits quality and bioactive compounds than other coating treatments. The results suggested that postharvest application of carnauba wax have a potential to extend storage life of pomegranate fruits by reducing respiration rate, water loss and maintaining fruit quality. PMID:26139918

  15. Physicochemical properties and aroma volatile profiles in a diverse collection of California-grown pomegranate (Punica granatum L.) germplasm.

    Beaulieu, J C; Lloyd, S W; Preece, J E; Moersfelder, J W; Stein-Chisholm, R E; Obando-Ulloa, J M

    2015-08-15

    Colorful antioxidant-rich fruits often convey astringency and sourness that juice consumers may not appreciate. We assessed properties in juices from a collection of California-grown pomegranate from the National Clonal Germplasm Repository. The goal was to evaluate overall differences in germplasm with quality traits classified as sweet, sweet-sour and sour. Previous relationships noted in sweet and sour cultivar attributes were observed. Wonderful generally clustered with sweet-sour and sour cultivars. Sweet low acid cultivars occasionally clustered closely with Wonderful which is hard to rationalize. The dominant compounds were 3-hexenol and 1-hexanol which allowed separation of Kara Gul, Haku-botan and Wonderful. Aldehyde and terpene content can be used to characterize cultivars. The study represents the first data on variation in juice qualities in different sweet, sweet-sour and sour cultivars, grown in California, compared with Wonderful. Data may help the juice industry better select raw juice materials in order to ultimately satisfy consumers. PMID:25794761

  16. Pomegranate (Punica granatum) Peel Extract as a Green Corrosion Inhibitor for Mild Steel in Hydrochloric Acid Solution

    Habib Ashassi-Sorkhabi; Shoja Mirzaee; Taghi Rostamikia; Robabeh Bagheri

    2015-01-01

    The inhibition effect of pomegranate peel extract (PPE) on the corrosion of mild steel in hydrochloric acid (HCl) solution was investigated. The polarization, mass loss, and electrochemical impendence techniques were used to evaluate the corrosion inhibition performance of the pomegranate peel extract. The results revealed that PPE acts as a corrosion inhibitor in HCl solution. The inhibition efficiency increased with the increase of extract concentration. The inhibition action was attributed...

  17. The Effect of Pomegranate (Punica granatum L.) Byproducts and Ellagitannins on the Growth of Human Gut Bacteria

    The consumption of pomegranate products leads to a significant accumulation of ellagitannins in the large intestines, where they interact with complex gut microflora. This study investigated the effect of pomegranate tannin constituents on the growth of various species of human gut bacteria. Our r...

  18. Anti-Glycation Effects of Pomegranate (Punica granatum L.) Fruit Extract and Its Components in Vivo and in Vitro.

    Kumagai, Yuya; Nakatani, Sachie; Onodera, Hideaki; Nagatomo, Akifumi; Nishida, Norihisa; Matsuura, Yoichi; Kobata, Kenji; Wada, Masahiro

    2015-09-01

    Accumulation of advanced glycation end products (AGEs) leads to various diseases such as diabetic complications and arteriosclerosis. In this study, we examined the effect of pomegranate fruit extract (PFE) and its constituent polyphenols on AGE formation in vivo and in vitro. PFE, fed with a high-fat and high-sucrose (HFS) diet to KK-A(y) mice, significantly reduced glycation products such as glycoalbumin (22.0 ± 2.4%), hemoglobin A1c (5.84 ± 0.23%), and serum AGEs (8.22 ± 0.17 μg/mL), as compared to a control HFS group (30.6 ± 2.6%, 7.45 ± 0.12%, and 9.55 ± 0.17 μg/mL, respectively, P < 0.05). In antiglycation assays, PFE, punicalin, punicalagin, ellagic acid, and gallic acid suppressed the formation of AGEs from bovine serum albumin and sugars. In this study, we discuss the mechanism of the antiglycation effects of PFE and its components in vivo and in vitro. PMID:26242637

  19. Antioxidant and Anti-Inflammatory Activities of Pomegranate (Punica granatum on Eimeria papillata-Induced Infection in Mice

    Omar S. O. Amer

    2015-01-01

    Full Text Available Coccidiosis is the most prevalent disease causing widespread economic loss, especially in poultry farms. Here, we investigated the effects of pomegranate peel extract (PPE on the outcome of coccidiosis caused by Eimeria papillata in mice. The data showed that mice infected with E. papillata and treated with PPE revealed a significant decrease in the output of oocysts in their faeces by day 5 p.i. Infection also induced inflammation and injury of the jejunum. This was evidenced (i as increases in reactive oxygen species, (ii, as increased neutrophils and decreased lymphocytes in blood (ii as increased mRNA levels of inducible nitric oxide synthase (iNOS, Bcl-2 gene, and of the cytokines interferon gamma (IFN-γ, tumour necrosis factor-α (TNF-α, and interleukin-1β (IL-1β, and (iv as downregulation of mucin gene MUC2 mRNA. All these infection-induced parameters were significantly altered during PPE treatment. In particular, PPE counteracted the E. papillata-induced loss of the total antioxidant capacity. Our data indicated that PPE treatment significantly attenuated inflammation and injury of the jejunum induced by E. papillata infections.

  20. Formulasi dan Uji Efek Anti-Aging dari Krim Mengandung Ekstrak Kulit Buah Delima (Punica granatum L)

    Ramadhilla, Nailul

    2015-01-01

    Anti-aging is a process that useful to prevent or slow down the effects of aging. Pomegranate peel is rich with flavonoids, phenolic acids, catechins and tannins which are using as an antioxidant. The objective of this study is to prepare an anti-aging cream using pomegranate peel extract and determine how long its to provide an anti-aging effects. This study was carried out experimentally. Pomegranate peel extracted by maceration using ethanol 70% and concentrated by using rotary evaporat...

  1. Pomegranate (Punica granatum Peel Extract as a Green Corrosion Inhibitor for Mild Steel in Hydrochloric Acid Solution

    Habib Ashassi-Sorkhabi

    2015-01-01

    Full Text Available The inhibition effect of pomegranate peel extract (PPE on the corrosion of mild steel in hydrochloric acid (HCl solution was investigated. The polarization, mass loss, and electrochemical impendence techniques were used to evaluate the corrosion inhibition performance of the pomegranate peel extract. The results revealed that PPE acts as a corrosion inhibitor in HCl solution. The inhibition efficiency increased with the increase of extract concentration. The inhibition action was attributed to the adsorption of the chemical compounds present in the extract solution, on mild steel surface.

  2. Influence of putrescine and carnauba wax on functional and sensory quality of pomegranate (Punica granatum L.) fruits during storage

    Barman, Kalyan; Asrey, Ram; Pal, R. K.; Kaur, Charanjit; Jha, S. K.

    2011-01-01

    Functional properties (anthocyanins, antioxidant, ascorbic acid and tannin) and sensory score were determined in pomegranate fruits at two storage temperatures (3 and 5 °C) after treatment with 2 mM putrescine and 1 : 10 carnauba wax (carnauba wax : water). The treatments (putrescine and carnauba wax) were given by immersion method followed by storage up to 60 days. Both treatments retained significantly higher anthocyanins, antioxidant, ascorbic acid, tannin and sensory qualities as compared...

  3. The effect of pomegranate (Punica granatum L.) byproducts and ellagitannins on the growth of human gut bacteria.

    Bialonska, Dobroslawa; Kasimsetty, Sashi G; Schrader, Kevin K; Ferreira, Daneel

    2009-09-23

    The consumption of pomegranate products leads to a significant accumulation of ellagitannins in the large intestines, where they interact with complex gut microflora. This study investigated the effect of pomegranate tannin constituents on the growth of various species of human gut bacteria. Our results showed that pomegranate byproducts and punicalagins inhibited the growth of pathogenic clostridia and Staphyloccocus aureus. Probiotic lactobacilli and bifidobacteria were generally not affected by ellagitannins, while relatively small growth inhibition by ellagic acid likely resulted from decreasing media quality due to the formation of tannin-protein complexes. The effect of pomegranate ellagitannins on bifidobacteria was species- and tannin-dependent. The growth of Bifidobacterium animalis ssp. lactis was slightly inhibited by punicalagins, punicalins, and ellagic acid. POMx supplementation significantly enhanced the growth of Bifidobacterium breve and Bifidobacterium infantis. PMID:19705832

  4. Evaluation of pomegranate rind (Punica granatum) hydroethanolic extract on blood parameters in male mice treated by Irinotecan Hcl

    N Mirazi; Sh Nosrati; Hosseini, A.

    2015-01-01

    Background & aim: Irinotecan Hcl is the first order drug for some neoplasm treatment in patients. Irinotecan Hcl has side effects on blood such as anemia and leukopeny. The aim of this study was to evaluate erythropoetic effects of the pomegranate hydroethanolic extract were examined on mice which treated by irinotecan Hcl. Methods: In this experimental study, 49 male mice (25-30 g) were divided in 7 groups (control, sham, treated by irinotecan Hcl (100 mg/kg), treated by pomegranate extr...

  5. Genome-wide identification of microRNAs in pomegranate (Punica granatum L.) by high-throughput sequencing

    Background: MicroRNAs (miRNAs), a class of small non-coding endogenous RNAs that regulate gene expression post-transcriptionally, play multiple key roles in plant growth and development and in biotic and abiotic stress response. Knowledge and roles of miRNAs in pomegranate fruit development have not...

  6. Biological studies of Oligonychus punicae (Acari: Tetranychidae) on grapevine cultivars.

    Vásquez, Carlos; Aponte, Orlando; Morales, José; Sanabria, María E; García, Grisaly

    2008-06-01

    Life cycle, fecundity and longevity of the avocado brown mite, Oligonychus punicae (Hirst), were studied on six grapevine cultivars (Tucupita, Villanueva, Red Globe, Sirah, Sauvignon and Chenin Blanc), under laboratory conditions at 27 +/- 2 degrees C, 80 +/- 10% RH, and L12:D12 photoperiod. Mite-infested leaves were collected from vineyards, placed in paper bags and taken to the laboratory. A laboratory mite culture was established using the grape cultivar Criolla Negra as host plant. To elucidate potential effects on avocado brown mite parameters, we assessed levels of secondary metabolites, such as alkaloids, flavonoids, tannins and polyphenols, of leaves of the six grape cultivars, as well as the thickness of the adaxial cuticle-epidermis. The life cycle of O. punicae differed among cultivars with average values ranging between 8.2 days on Tucupita leaves and 9.1 days on Sirah. Relatively high fecundity was found on Tucupita leaves (2.8 eggs/female/day) during 11.4 oviposition days, while low fecundity values occurred on Sirah and Villanueva leaves, with 0.9 and 1.8 eggs/female/day during 7.9 and 6.7 days, respectively. Average longevity of O. punicae females ranged from 8.1 to 17.5 days on Sirah and Sauvignon leaves, respectively. Intrinsic rate of increase (r (m)) was highest on Sauvignon (0.292) and Tucupita (0.261), and lowest on Sirah (0.146) and Villanueva (0.135). Although significant differences in cuticle-epidermis thickness were detected among the six cultivars, it seemed not to affect mite parameters. Secondary metabolite content also varied between the cultivars. Generally, increasing flavonoid content coincided with decreasing reproductive parameters. The natural plant resistance observed in this study could be useful in the development of an integrated pest management program for mite pests in grape production. PMID:18483791

  7. CHARACTERIZATION OF XANTHOMONAS AXONOPODIS PV. PUNICAE ISOLATES FROM WESTERN MAHARASHTRA AND THEIR SENSITIVITY TO CHEMICAL TREATMENTS

    K. S. RAGHUWANSHI; B. A. HUJARE; V. P. CHIMOTE; S. G. BORKAR

    2013-01-01

    Bacterial blight of pomegranate caused by Xanthomonas axonopodis pv. punicae is a major biotic constraint inpeninsular India. Field survey was undertaken in the major pomegranate growing regions of Western Maharashtra,which revealed the high prevalence of bacterial blight incidence in Solapur, Sangli and Nashik districts. Fourdifferent isolates of this pathogen were obtained from the highly infected plant materials collected during the fieldsurvey. X. axonopodis pv. punicae was detected from ...

  8. Study of pomegranate (Punica granatum L. peel extract containing anthocyanins on fatty streak formation in the renal arteries in hypercholesterolemic rabbits

    Fatemeh Sharifiyan

    2016-01-01

    Conclusion: The results of this study indicate that consumption of pomegranate peel extract containing anthocyanins (polyphenol content 1 g/kg diet despite of a significant increase in serum antioxidant capacity cannot protect the kidneys from hypercholesterolemia-induced damages during the treatment period.

  9. BİR ZİRAAT COĞRAFYASI ÇALIŞMASI: TÜRKİYE’DE NAR (Punica granatum L.) TARIMI

    KURT, HALİL; ŞAHİN, Güven

    2013-01-01

    Pomegranate plant that its homeland is Asia Minor is one of the oldest cultivated agricultural products. Pomegranate finds the most common habitat between tropics 40º latitudes, in regions where Mediterranean rainfall regime to be effective, fields up to 1000 meters altitude from the coast. Respectively, the Mediterranean, Aegean and Southeast Anatolia are the regions producing the most amount of pomegranate in Turkey. In terms of provinces, Antalya, Mugla, Mersin and Adana are foremost in po...

  10. 石榴抗糖尿病生物活性的研究进展%Research progress in anti-diabetic actions of pomegranate( Punica granatum L.)

    刘慧; 赵文恩; 康保珊

    2012-01-01

    体外和体内实验均证实石榴汁、石榴皮、石榴花、石榴籽和石榴叶等具有抗糖尿病的功效,综述了石榴多个部位的降血糖效果、降血糖活性成分及其作用机制的研究进展。石榴中的多酚类是抗糖尿病的主要活性物质,主要通过提高胰岛素受体敏感性、增强PPAR-γ(Peroxisome proliferator—activated receptor,过氧化酶体增殖物激活受体)的表达、抑制α-葡萄糖苷酶活性等作用达到抗糖尿病的功效,为石榴的进一步开发利用提供参考。%There are anti-diabetic constituents in several parts of pomegranate including juice, peels, flowers, seeds,and leaves in vivo or vitro research.The anti-diabetic activities, major active compounds and mechanisms of different parts in pomegranate were summarized in this paper.Polyphenols were the major active components for anti-diabetic activity.The sensitivity of insulin receptor and the expression of peroxisome proliferator-activated receptor were improved as well as the activity of a-glucosidase was inhibited, which were major reasons for hypoglycemic activity of pomegranate. The results provide a powerful support for further development of pomegranate utilization.

  11. A "White" Anthocyanin-less Pomegranate (Punica granatum L.) Caused by an Insertion in the Coding Region of the Leucoanthocyanidin Dioxygenase (LDOX; ANS) Gene

    Zohar Ben-Simhon; Sylvie Judeinstein; Taly Trainin; Rotem Harel-Beja; Irit Bar-Ya'akov; Hamutal Borochov-Neori; Doron Holland

    2015-01-01

    Color is an important determinant of pomegranate fruit quality and commercial value. To understand the genetic factors controlling color in pomegranate, chemical, molecular and genetic characterization of a "white" pomegranate was performed. This unique accession is lacking the typical pomegranate color rendered by anthocyanins in all tissues of the plant, including flowers, fruit (skin and arils) and leaves. Steady-state gene-expression analysis indicated that none of the analyzed "white" po...

  12. Anti-proliferative effects of polyphenols from pomegranate rind (Punica granatum L.) on EJ bladder cancer cells via regulation of p53/miR-34a axis.

    Zhou, Benhong; Yi, Huilan; Tan, Jun; Wu, Yue; Liu, Gang; Qiu, Zhenpeng

    2015-03-01

    miRNAs and their validated miRNA targets appear as novel effectors in biological activities of plant polyphenols; however, limited information is available on miR-34a mediated cytotoxicity of pomegranate rind polyphenols in cancer cell lines. For this purpose, cell viability assay, Realtime quantitative PCR for mRNA quantification, western blot for essential protein expression, p53 silencing by shRNA and miR-34a knockdown were performed in the present study. EJ cell treatment with 100 µg (GAE)/mL PRE for 48 h evoked poor cell viability and caspase-dependent pro-apoptosis appearance. PRE also elevated p53 protein and triggered miR-34a expression. The c-Myc and CD44 were confirmed as direct targets of miR-34a in EJ cell apoptosis induced by PRE. Our results provide sufficient evidence that polyphenols in PRE can be potential molecular clusters to suppress bladder cancer cell EJ proliferation via p53/miR-34a axis. PMID:25572695

  13. Polyphenol Extracts from Punica granatum and Terminalia chebula are anti-inflammatory and increase the survival rate of chickens challenged with Escherichia coli

    Avian pathogenic Escherichia coli (APEC) causes avian colibacillosis, inflammation in multi-organs of chickens, and results in serious economic loss to the chicken industry. Polyphenolic compounds possess a wide range of physiological activities that may contribute to their beneficial effects again...

  14. Ülkemizde Yetiştirilen Önemli Nar (Punica granatum) Çeşitlerine Ait Çekirdeklerin Bazı Özellikleri

    GÖLÜKCÜ, Muharrem; TOKGÖZ, Haluk; Kıralan, Mustafa

    2008-01-01

    Bu çalışma kapsamında, Türkiye'de ticari boyutta yetiştirilen 15 nar çeşidine ait meyvelerin çekirdek oranları, çekirdeklerin bazı fiziksel ve kimyasal özellikleri ile bazı mineral madde içerikleri belirlenmiştir. Araştırma kapsamında incelenen nar çeşitlerinin çekirdek oranları %8.11 ile %15.11 ve çekirdeklerin bin dane ağırlıkları 19.36 g ile 36.81 g arasında değişim göstermiştir. Örneklerin çeşitlere göre yağ, protein, kül ve toplam fenolik madde içerikleri sırasıyla kurumadde üzerind...

  15. The inhibition of malignant epithelial cells in mucosal injury in the oral cavity of strains by pomegranate fruit extract (Punica granatum linn through Bcl-2 expression

    Sri Hernawati

    2013-03-01

    Full Text Available Background: Squamous cell carcinoma of oral cavity is a malignant neoplasms derived from epithelia. The malignant neoplasms are cells that have changed their structure and function, and their number becomes increasing abnormally, invasive, and metastatic. Carcinoma can be caused by the resistance of malignant cell apoptosis. Bcl-2 is a proto-oncogene of Bcl family that inhibits the process of cell apoptosis and suppresses Bax protein (pro-apoptotic. The management efforts of cancer diseases, however, still have many obstacles. Thus, the researcher was triggered to explore more herbal plants, namely pomegranate. Pomegranate as a medicinal plant is accessible and cheap. Ellagic acid (EA is a single active compound derived from whole pomegranate fruit extract (PGL, which has anti-cancer activity as in vitro, but EA is low concentration in plasma, low water solubility, and insoluble in intestinal. These facts prompted the researcher to compare between pomegranate extract, which consists of several active compounds, and that, which only consists of ellagic acid. Thus, this research is expected to know how some active compounds can work synergistically in the PGL, so the effect can be more potent. Purpose: The purpose of this research, therefore, was to compare EA with PGL in reducing the expression of Bcl-2. Methods: This laboratory experimental research was used 32 male mice (Balb/c in the age of 5 months. They were randomly divided into 4 groups: 2 control groups (K0: which was not exposed with benzopirene and also untreated and K1: which was exposed with benzopirene and also untreated, 2 treatment groups (P1: which was exposed with benzopirene and also treated with EA and P2: which was exposed with benzopirene and also treated with the PGL. Next, an examination was conducted by using immunohistochemical techniques. results: The results then showed that the provision of the PGL could decrease the expression of Bcl-2 significantly higher than that of EA in the malignant epithelial cells of the oral mucosa of those mice. Conclusion: It may be concluded that the provision of the PGL can kill malignant cells in the oral cavity of mice by increasing apoptosis through decreasing Bcl-2 expression that was higher than the provision of EA.latar belakang: Karsinoma sel skuamosa rongga mulut adalah istilah yang digunakan menyebut neoplasma ganas berasal dari epitel. Neoplasma ganas adalah sel yang telah berubah struktur dan fungsi, sehingga mengalami peningkatan jumlah secara abnormal,invasif dan metastasis. Terjadinya karsinoma salah satu disebabkan oleh karena hambatan apoptosis terhadap sel ganas. Bcl-2 adalah protoonkogen keluarga Bcl yang berperan menghambat proses apoptosis sel dan bekerja menekan protein Bax (pro apoptosis. Berbagai upaya penatalaksanaan penyakit kanker masih banyak menemui kendala,sehingga peneliti menggali tanaman obat yaitu buah delima. Buah delima sebagai tanaman obat, mudah didapat dan harganya murah. Ellagic acid (EA senyawa tunggal bahan aktif dari ekstrak buah delima yang memiliki aktivitas sebagai anti kanker secara in-vitro tetapi EA aktivitas dan konsentrasinya dalam plasma rendah, kelarutan dalam air rendah, metabolisme (EA tidak larut dalam intestinal. Fakta ini mendorong peneliti untuk membandingkan dengan whole ekstrak delima (PGL yang terdiri dari beberapa senyawa bahan aktif, tidak hanya ellagic acid, memungkinkan beberapa senyawa bahan aktif pada PGL bisa bekerja sinergis, sehingga efeknya lebih poten. tujuan: Tujuan penelitian ini membandingkan antara EA, dengan whole ekstrak buah delima (PGL dalam menurunkan ekspresi Bcl-2. Metode: Metode penelitian yang digunakan adalah eksperimental laboratories, 32 ekor mencit (Balb/c, jantan, umur 5 bulan dibagi secara random menjadi 4 kelompok, 2 kelompok kontrol (K0: tidak dipapar benzopirene dan tidak diberi perlakuan, K1: dipapar benzopirene dan tidak diberi perlakuan, 2 kelompok perlakuan (P1: dipapar benzopirene dan diberi EA, P2: dipapar benzopirene dan diberi PGL. Pemeriksaan dengan menggunakan teknik imunohistokimia. hasil: Hasil penelitian menunjukkan bahwa pemberian PGL dapat menurunkan ekspresi Bcl-2 lebih tinggi dibandingkan EA pada sel epitel ganas mukosa rongga mulut mencit. Kesimpulan: Kesimpulan penelitian ini adalah pemberian PGL dapat membunuh sel ganas pada rongga mulut mencit dengan jalan meningkatkan apoptosis melalui penurunan ekspresi Bcl-2 lebih tinggi dibandingkan pemberian EA.

  16. Plantlet Regeneration from the Embryo of Punica granatum cv.Nana in vitro%大花石榴胚培养再生植株

    闵炜; 陈志萍

    2010-01-01

    以大花石榴的胚为外植体在MS+BA1+NAA0.2培养基中诱导愈伤并产生不定芽,在MS+BA0.5+NAA0.2培养基中进行芽苗的增殖培养,在1/2MS+ NAA0.5+IBA0.5培养基中诱导芽苗生根.试管苗在珍珠岩基质中罩塑料杯保湿炼苗后即可移栽入土中.

  17. ISOLATION IPG3-1 AND IPG3-3, ENDOPHYTIC FUNGI FROM DELIMA (PUNICA GRANATUM LINN. TWIGS AND IN VITRO ASSESSMENT OF THEIR ANTI MICROBIAL ACTIVITY

    Shirly Kumala

    2013-06-01

    Full Text Available IPG3-1,2,3,4,5 were endophytic fungi isolated from Delima twigs via direct seed inoculation on Potato Dextrose Agar (PDA. Macroscopic identification of the isolates showed clearly that IPG3-3 and 4 have radial wrinkles in the centre with black spots while IPG3-5 has flower shape in the middle. The microscopic observation on the other hand, showed that IPG3-1 and 3 has branched septate while IPG3-4 has unbranched septate. Furthermore, IPG3-2 and 5 were branched but septateless. Overall, these endophytes showed no spore formation. Secondary metabolites of IPG3-1 and IPG3-3 endophytic fungi isolates demonstrated stronger inhibition zone percentage against Candida albicans and than towards Staphylococcus aureus and Escherichia coli when campare to their respectively positive control amphotericin B and Chloramphenicol.

  18. Meat composition, fatty acid profile and oxidative stability of meat from broilers supplemented with pomegranate (Punica granatum L.) by-products.

    Ahmed, Sonia Tabasum; Islam, Md Manirul; Bostami, A B M Rubayet; Mun, Hong-Seok; Kim, Ye-Jin; Yang, Chul-Ju

    2015-12-01

    The effects of diets supplemented with four levels (0%, 0.5%, 1.0% and 2.0%) of pomegranate by-product (PB) on meat composition, fatty acid profile and oxidative stability of broiler meat were evaluated. The crude protein and moisture contents increased, whereas ether extract in breast and thigh meat and cholesterol in breast meat decreased in response to dietary PB supplementation (p<0.05). In breast and thigh meat, the sum of saturated fatty acids was lower, while the sum of mono-unsaturated and n-3 fatty acids were higher, alongside lower n-6/n-3 ratio in the 1.0% and 2.0% PB supplemented group (p<0.05). The TBARS values and pH of breast and thigh meat were reduced in the PB supplemented groups (p<0.05). Overall, the results presented herein indicate that supplementation of diets with up to 2% pomegranate by-products improved the meat composition, fatty acid profile and reduced lipid oxidation of broiler meat. PMID:26041221

  19. Inhibitory effect of pomegranate (Punica granatum L.) polyphenol extracts on the bacterial growth and survival of clinical isolates of pathogenic Staphylococcus aureus and Escherichia coli.

    Pagliarulo, Caterina; De Vito, Valentina; Picariello, Gianluca; Colicchio, Roberta; Pastore, Gabiria; Salvatore, Paola; Volpe, Maria Grazia

    2016-01-01

    In the present study major polyphenols of pomegranate arils and peel by-products were extracted in 50% (v/v) aqueous ethanol, characterized and used in microbiological assays in order to test antimicrobial activity against clinically isolated human pathogenic microorganisms. Total concentration of polyphenols and in vitro antioxidant properties were determined by the Folin-Ciocalteu and DPPH methods, respectively. The most abundant bioactive molecules, including anthocyanins, catechins, tannins, gallic and ellagic acids were identified by RP-HPLC-DAD, also coupled to off-line matrix assisted laser desorption/ionization (MALDI-TOF) mass spectrometry (MS). The inhibitory spectrum of extracts against test microorganisms was assessed by the agar well-diffusion method. Data herein indicated that both pomegranate aril and peel extracts have an effective antimicrobial activity, as evidenced by the inhibitory effect on the bacterial growth of two important human pathogens, including Staphylococcus aureus and Escherichia coli, which are often involved in foodborne illness. PMID:26213044

  20. DYYABETYK SIÇANLARDA NAR (Punica granatum) ÇYÇE?YNYN SERUMDAKY ASPARTAT AMYNOTRANSFERAZ VE ALANYN AMYNOTRANSFERAZ DÜZEYLERYNE ETKYLERYNYN ARA?TIRILMASI

    ÇAMBAY, ZAFER

    2011-01-01

    Bu çaly?mada, STZ ile diyabet olu?turulmu? ratlarda nar çiçe?inin AST(Aspartat Aminotransferaz) ve ALT (Alanin Aminotransferaz) gibi karaci?er enzimlerindeki etkileri ara?tyrylmy?tyr. Naryn özelikle çiçe?i içerdi?i zengin polifenolik bile?ikler ve flavonoidler sayesinde diyabetin tedavisinde kullanylmaktadyr. Syçanlar her grupta 12 hayvan olmak üzere Kontrol, diyabet(STZ), STZ+NÇI(300mg/kg/gün), STZ+NÇII(400mg/kg/gün), STZ+NÇIII (500mg/kg/gün) be? gruba ayryldy. Diyabet hastaly?yndan dolayy ...

  1. The Effect of Two Methods of Pomegranate (Punica granatum L Juice Extraction on Quality During Storage at 4∘C

    Graça Miguel

    2004-01-01

    Full Text Available The effect of two extraction methods of pomegranate juice on its quality and stability was evaluated. The first method consisted of separation of the seeds from fruits and centrifugation. The second method consisted of squeezing fruit halves with an electric lemon squeezer. During a period of 72 hours of cold storage at 4∘C, the juices were evaluated for the presence of sugars, organic acids, and anthocyanins. Delphinidin 3-glucoside was identified to be the major anthocyanin present at the level of 45–69 mg/L. Among the organic acids, oxalic and tartaric acids dominated. The major sugars detected in pomegranate juice were glucose and sucrose. No significant differences in the content of sugars, organic acids, or anthocyanins in juices obtained through application of the two different extraction methods were detected, with the exception of the drastic decrease of cyanidin 3,5-diglucoside level in juice obtained by seed centrifugation. The pH did not show differences between treatments. Titrable acidity and the level of sugars expressed as ∘Brix decreased after 32 and 15 hours after extraction, respectively, when juice was obtained by centrifuging the seeds.

  2. Protective effect of pomegranate (Punica granatum Linn.) juice against hepatotoxicity and testicular toxicity induced by ethanol in mice

    Ampa Luangpirom; Thanaree Junaimuang; Watchara Kourchampa; Pichet Somsapt; Opass Sritragool

    2013-01-01

    Ethanol commonly causes hepatotoxicity and testicular toxicity after chronic consumption. Silymarin, a commercial drug for protective and curative treatment of liver disease, was used as a standard drug. This study aimed to evaluate the protective activities of pomegranate juice on liver damage and sperm quality impairment caused by ethanol consumption. The experiment was conducted on 5 groups of male mice. Group I as negative control received distilled water, group II as positive...

  3. Antimicrobial Activity of Aloevera barbedensis, Daucus carota, Emblica officinalis, Honey and Punica granatum and Formulation of a Health Drink and Salad

    Jeswin Philip

    2012-09-01

    Full Text Available Aims: Indian folk medicine has been in practice from time immemorial. Traditional medicine interconnects our body with nature for a healthy living. The naturally occurring antimicrobials in food vary in their efficacy and function, toxicology, safety and mechanism of action against microorganisms.Methodology and Results: The study revitalizes the traditional system of medicine in order to achieve self reliance in health care and health for all by analyzing the antimicrobial property of aqueous extracts of aloevera (Aloevera barbedensis, carrot (Daucus carota, Indian gooseberry (Emblica officinalis, honey and pomegranate (Punicagranatum, and to assess the reason for inhibition of growth of pathogenic organisms by DNA and protein analysis. Various aqueous extracts showed inhibition to microrganisms like Escherichia coli, Pseudomonas aeruginosa, Salmonella typhi, Shigella flexineri and Staphylococcus aureus.Conclusion significance and impact of study: The study also formulated and standardized a nourishing health drink and salad using the tested foods and estimated their shelf life and nutritive value. The health drink and salad had a low protein, low fat and moderate carbohydrate content. Therapeutically this drink and salad can be used to treat obesity.

  4. In vitro antioxidant, collagenase inhibition, and in vivo anti-wrinkle effects of combined formulation containing Punica granatum, Ginkgo biloba, Ficus carica, and Morus alba fruits extract

    Ghimeray AK; Jung US; Lee HY; Kim YH; Ryu EK; Chang MS

    2015-01-01

    Amal Kumar Ghimeray,1 Un Sun Jung,1,2 Ha Youn Lee,1 Young Hoon Kim,1 Eun Kyung Ryu,1 Moon Sik Chang11R&D Center, Natural Solution Co., Ltd, Gojan-dong, Namdong-gu, Incheon, Republic of Korea; 2Department of Horticultural Biotechnology, Kyung Hee University, Yongin, Republic of KoreaBackground: In phytotherapy, the therapeutic potential is based on the combined action of different herbal drugs. Our objective was to evaluate the antioxidant, anti-collagenase (in vitro), and anti-wrinkle (in...

  5. In vitro antioxidant, collagenase inhibition, and in vivo anti-wrinkle effects of combined formulation containing Punica granatum, Ginkgo biloba, Ficus carica, and Morus alba fruits extract

    Ghimeray, Amal

    2015-01-01

    Amal Kumar Ghimeray,1 Un Sun Jung,1,2 Ha Youn Lee,1 Young Hoon Kim,1 Eun Kyung Ryu,1 Moon Sik Chang11R&D Center, Natural Solution Co., Ltd, Gojan-dong, Namdong-gu, Incheon, Republic of Korea; 2Department of Horticultural Biotechnology, Kyung Hee University, Yongin, Republic of KoreaBackground: In phytotherapy, the therapeutic potential is based on the combined action of different herbal drugs. Our objective was to evaluate the antioxidant, anti-collagenase (in vitro), and anti-wrinkle...

  6. Antimicrobial Activity of Aloevera barbedensis, Daucus carota, Emblica officinalis, Honey and Punica granatum and Formulation of a Health Drink and Salad

    Jeswin Philip; Sheila John; Priya Iyer

    2012-01-01

    Aims: Indian folk medicine has been in practice from time immemorial. Traditional medicine interconnects our body with nature for a healthy living. The naturally occurring antimicrobials in food vary in their efficacy and function, toxicology, safety and mechanism of action against microorganisms.Methodology and Results: The study revitalizes the traditional system of medicine in order to achieve self reliance in health care and health for all by analyzing the antimicrobial property of aqueou...

  7. Potensi limbah kulit buah Nyirih Xylocarpus granatum sebagai inhibitor tirosinase

    Mohamad Gazali

    2014-01-01

    Full Text Available The aim of the present study was to analyse the peel waste of Xylocarpus granatum fruits as potential source of tyrosinase inhibitors. Dried peel samples were ground to yield a powder (simplicia. Subsequently, they were extracted with organic solvents of distinct polarity levels, namely n-hexane (non-polar, chloroform (semi-polar and methanol (polar by use of the single-maceration method. Inhibitory effects on tyrosinase activity (monophenolase and DOPA auto-oxidation (diphenolase were determined in bioassays. Assays with the methanol extract revealed IC50 values of 784.87 μg mL-1 (monophenolase and of 1176.66 μg mL-1 (diphenolase, respectively. In contrast, n-hexane and chloroform extracts showed no activity. These results indicate that the methanolic fruit peel extract contained tyrosinase-inhibiting compounds, such as flavonoids, tannins and saponins, whereas the n-hexane and chloroform extracts yielded alkaloids, steroids and triterpenoids without tyrosinase-inhibiting activity. The phenolic compounds had a strong effect on the tyrosinase enzymes, inhibiting monophenolases by 97% and diphenolases by 96%, with a positive correlation between the total phenolic content and the inhibition rate in both activities.

  8. A new pomegranate pest for Turkey; Pomegranate false spidermite, Tenuipalpus punicae Pirtchard and Baker (Acari: Tenuipalpidae)

    DÖKER, İsmail; KAZAK, Cengiz; KARUT, Kamil

    2013-01-01

    In this study, the pomegranate false spider mite Tenuipalpus punicae Pirtchard and Baker (Acari: Tenuipalpidae) collected from pomegranate growing areas of Adana province is determined for the first record for Turkish mite fauna. Some information related to world distribution, damage, biology and control of this pest are presented in the paper.

  9. Hairy AdS Solitons

    Anabalon, Andres; Choque, David

    2016-01-01

    We construct exact hairy AdS soliton solutions in Einstein-dilaton gravity theory. We discuss the role of these solutions for the existence of first order phase transitions for planar hairy black holes within these theories.

  10. Added Sugars

    ... Restaurant Deciphering the Menu Ordering Your Meal Eating Fast Food Dining Out Tips by Cuisine Physical Activity Fitness ... Learn more about reading food labels . Limit your consumption of foods with high amounts of added sugars, ...

  11. Effects of water extracts of apple and pomegranate peel on the quality of orange squash

    Salah-ud Din; Kashif Akram; Umar Farooq; Afshan Shafi; Farkhandah Sarfraz; Hafeez ur Rehman; Muhammad Asim Ijaz Sidhu

    2015-01-01

    Punica granatum (pomegranate) and Malus domestica (apple) are rich source of bioactive compounds i.e. phenolics components, anthocyanins and tannins that can be potential preservative agents. The aim of the present research plan was to evaluate the quality characteristics of orange squash after addition of aqueous extracts of apple and pomegranate peels. For this purpose aqueous extracts of pomegranate and apple peels were added in orange squash and then the final product was examined for phy...

  12. Effects of Flavonoid-rich Plant Extracts on In vitro Ruminal Methanogenesis, Microbial Populations and Fermentation Characteristics

    Kim, Eun T.; Guan, Le Luo; Lee, Shin J.; Sang M. Lee; Lee, Sang S.; Lee, Il D.; Lee, Su K.; Lee, Sung S.

    2015-01-01

    The objective of this study was to evaluate the in vitro effects of flavonoid-rich plant extracts (PE) on ruminal fermentation characteristics and methane emission by studying their effectiveness for methanogenesis in the rumen. A fistulated Holstein cow was used as a donor of rumen fluid. The PE (Punica granatum, Betula schmidtii, Ginkgo biloba, Camellia japonica, and Cudrania tricuspidata) known to have high concentrations of flavonoid were added to an in vitro fermentation incubated with r...

  13. CHARACTERIZATION OF XANTHOMONAS AXONOPODIS PV. PUNICAE ISOLATES FROM WESTERN MAHARASHTRA AND THEIR SENSITIVITY TO CHEMICAL TREATMENTS

    K. S. RAGHUWANSHI

    2013-01-01

    Full Text Available Bacterial blight of pomegranate caused by Xanthomonas axonopodis pv. punicae is a major biotic constraint inpeninsular India. Field survey was undertaken in the major pomegranate growing regions of Western Maharashtra,which revealed the high prevalence of bacterial blight incidence in Solapur, Sangli and Nashik districts. Fourdifferent isolates of this pathogen were obtained from the highly infected plant materials collected during the fieldsurvey. X. axonopodis pv. punicae was detected from infected plant material and its identity was confirmed bymorphological, physiological, hypersensitive and pathogenicity tests. Nashik isolate was most virulent. On InterSimple Sequence Repeat (ISSR analysis they formed separate clusters with Akkalkot-Solapur isolate being mostdivergent, while Deola-Nashik and Sangamner-Ahmednagar isolates were most similar. Six chemical treatmentsshowed complete control under in vitro conditions while rest varied in their response to isolates. Completecontrol in all four isolates was observed with Bordeaux mixture (1%; captan (0.25% + Copper oxychloride(0.3%, captan (0.25% + copper hydroxide (0.3%, bromopol (500 ppm + copper oxychloride (0.3%,streptocycline (250 ppm + copper hydroxide (0.3%, streptocycline (500 ppm + copper hydroxide (0.3%during in vitro study

  14. Wormholes in AdS

    Maldacena, Juan; Maoz, Liat

    2004-01-01

    We construct a few Euclidean supergravity solutions with multiple boundaries. We consider examples where the corresponding boundary field theory is well defined on each boundary. We point out that these configurations are puzzling from the AdS/CFT point of view. A proper understanding of the AdS/CFT dictionary for these cases might yield some information about the physics of closed universes.

  15. Adding Ajax

    Powers, Shelley

    2007-01-01

    Ajax can bring many advantages to an existing web application without forcing you to redo the whole thing. This book explains how you can add Ajax to enhance, rather than replace, the way your application works. For instance, if you have a traditional web application based on submitting a form to update a table, you can enhance it by adding the capability to update the table with changes to the form fields, without actually having to submit the form. That's just one example.Adding Ajax is for those of you more interested in extending existing applications than in creating Rich Internet Applica

  16. Molecular and morphological identification of hymenoptran parasitoids from the pomegranate aphid, Aphis punicae in Razavi Khorasan province, Iran

    FARROKHZADEH, Hadi; Moravvej, Gholamhossein; Awal, Mehdi Modarres; Karimi, Javad

    2014-01-01

    Parasitoids play the positive role in aphids control management by keeping the population of aphids below the economic threshold. The pomegranate aphid, Aphis punicae is attacked by several parasitoids which mostly belong to Aphidiinae subfamily. The identification of parasitoids and hyperparasitoids is problematic due to their small size and ambiguous morphological characteristics. The analysis of molecular data of DNA sequences has been suggested as a complementary approach to the classical...

  17. Determination and Comparison of Pigment Contents in Leaves of Punica granatum L.Hybrids with Different Leaf Colors%不同叶色石榴杂种单株叶片色素含量的比较

    郭晓丽; 李洪涛; 李东伟; 张丽婷; 昊亚君; 陈延惠

    2013-01-01

    [目的]石榴杂种后代不同叶片颜色的成因.[方法]采用分光光度法对8个石榴杂种单株和2个亲本对照单株生长期叶片中叶绿素、类胡萝卜素和花青素的含量进行了研究.[结果]在生长初期,叶片表现红色的4个单株花青素含量均高于对照,其中5号单株花青素含量最高,达到4.12 mg/g;叶片表现黄绿色的4个单株叶绿素与类胡萝卜素的含量变化趋势与对照基本一致,其中4号单株叶绿素的含量和叶绿素/类胡萝卜素的值最高,而3号单株叶绿素a/叶绿素b的值最低.在生长旺盛期,8个石榴单株叶绿素、类胡萝卜素和花青素含量的变化趋势一致,与对照无明显差异.经方差分析,不同石榴单株在不同的生长期其叶绿素和类胡萝卜素含量均存在显著差异,不同石榴单株间花青素含量存在显著差异,而不同石榴单株在不同的生长期其叶绿素/类胡萝卜素的值不存在显著差异.[结论]石榴杂种后代间叶片颜色不同是由于生长期花青素、叶绿素含量和比值不同造成的.%[Objective] This study aimed to investigate the reason for the different leaf colors of pomegranate hybrid progeny.[Method] Spectrophotometry was used to determine the contents of three pigments,including chlorophyll,carotenoid and anthocyanin,in the leaves of eight pomegranate individuals and their parents at growth stage.[Result] The results showed that during the early growth stage,the anthocyanin contents of four pomegranate individuals with red leaves were higher than the control,to be specific,the anthocyanin content of No.5 pomegranate individual reached the highest of 4.12 mg/g; the chlorophyll and carotenoid contents of four pomegranate individuals with yellow-green leaves showed consistent dynamic trends with the control,to be specific,the chlorophyll content and chlorophyll/carotenoid ratio of No.4 pomegranate individual reached the highest,while the chlorophyll a/carotenoid b ratio of No.3 pomegranate individual was the lowest.During vigorous growth stage,the contents of chlorophyll,carotenoid and anthocyanin of eight pomegranate individuals showed consistent dynamic trends,with no significant difference with the control.Analysis of variance indicated that there were significant differences in the contents of chlorophyll and carotenoid among different pomegranate individuals at different growth stages and in the content of anthocyanin among different pomegranate individuals,while no significant difference was observed in the chlorophyll/carotenoid ratio among different pomegranate individuals at different growth stages.[Conclusion] The differonces in leaf colors among pomegranate hybrid progeny are caused by different contents and ratios of anthocyanin and chlorophyll at growth stage.

  18. 石榴皮总黄酮的提取及其体外抗氧化活性测定%Extraction and Free Radical Scavenging Activity of Total Flavonoids from the Peel of Punica granatum Linn.

    库尔班江·巴拉提; 阿依努尔

    2015-01-01

    以总黄酮的含量为考察指标,采用正交试验优化了石榴皮总黄酮的提取工艺条件;分别采用清除 DPPH 自由基能力及铁离子还原能力对石榴皮总黄酮的体外抗氧化活性进行了测定与评价.结果表明,石榴皮总黄酮的回流提取最佳工艺为:以体积分数70%的乙醇为提取溶剂、料液比为1∶20、提取温度为80℃、提取时间为2h时,石榴皮总黄酮的提取率达到22.6%,影响石榴皮总黄酮提取效果的主次因素为:乙醇体积分数>提取温度>料液比>提取时间;石榴皮总黄酮对DPPH自由基的最大清除率为80.59%,其IC50值为31.59mg/L.石榴皮总黄酮具有较高的抗氧化活性,且其体外抗氧化能力在一定范围内随着总黄酮质量浓度的增加而增强,可以作为天然抗氧化剂原料.%Taking the content of total flavonoids as index,orthogonal experiment to optimize the extraction pro⁃cess of total flavonoids of pomegranate peel were used to clear the DPPH radical scavenging and ferric reducing ability of pomegranate peel total flavonoids in vitro antioxidant activity of Determination and Evaluation. The results showed that total flavonoids of pomegranate peel extract reflux optimum extraction process: the volume fraction of 70% ethanol as extraction solvent,solid-liquid ratio was 1∶20,extraction temperature of 80℃,extraction time was 2h,the pomegranate rind total flavonoids extraction rate reached 22.6%,affecting the extraction of total flavo⁃noids of pomegranate peel primary and secondary factors as: ethanol concentration> extraction temperature> solid-liquid ratio> extraction time; total flavonoids of pomegranate peel largest DPPH radical scavenging rate 80.59%with an IC50 value of 31.59mg/L. Pomegranate rind with higher total flavonoid antioxidant activity and in vitro antiox⁃idant capacity increases within a certain range of the mass concentration of total flavonoids and enhanced as a natu⁃ral antioxidant ingredients.

  19. Optimization of the Extraction Process of Polyphenols from the Flower of Pomegranate(Punica granatum L.)in Xinjiang%新疆石榴花多酚的提取工艺

    热依木古丽·阿布都拉; 刘力; 阿吉艾克拜尔·艾萨

    2011-01-01

    采用单因素和正交试验,考察提取溶剂、提取时间、提取温度、料液比等因素对石榴花多酚提取的影响.结果显示:石榴花中多酚的最佳提取条件为以体积分数60%乙醇作溶剂、料液比1:20(g/mL)、温度50℃、提取时间1h;在该优化条件下提取,多酚粗提物的得率为44.20%、纯度46.19%,即石榴花多酚得率达到20.42%.该方法操作简便、成本低、提取效果好,适合于工业化大生产.

  20. 石榴酒、蜂蜜酒营养价值和保健作用的比较%The Comparation of Nutrients Value and Health-care Function Between the Full Fermentation Punica Granatum Wine and Mead.

    濮智颖; 翟文俊

    2008-01-01

    本文通过对石榴酒、蜂蜜酒中矿物质元素、维生素、氨基酸、蛋白质、糖类等营养成分的分析测定,阐述了这两种果酒的共同营养特点和各自独特的营养价值.

  1. 四川会理石榴产业化开发的构想%Thoughts on exploitation and industrialization of Punica granatum L. In Huili county Sichuan province

    潭兴荣

    2001-01-01

    会理石榴是国内主要名产之一,尤以主栽品种--青皮软籽石榴,独树一帜,久负盛名.作者结合会理县的自然地理优势和已有的石榴种植经验和技术条件,论述了石榴在促进农业产业结构调整和石榴系列产品实行产业化经营方面的经验和做法.

  2. 利用超临界技术萃取石榴叶总酚工艺研究%Orthogonal Array Design as An Approach to Optimize Supercritical Fluid Extraction Conditions of Total Polyphenols from Punica granatum L. Leaves

    王华

    2009-01-01

    利用超临界CO2装置对石榴叶中总酚提取工艺进行研究,以期得到高生理活性和高纯度的石榴叶活性物质.通过单因素和正交试验,得到最佳萃取条件为料液比1:2.5(g/ml)、萃取压力25MPa、萃取温度60℃、萃取时间120min.活性物质得率为0.1728%,纯度为42.61%.

  3. Online Ad Assignment with an Ad Exchange

    Dvořák, Wolfgang; Henzinger, Monika

    2016-01-01

    Ad exchanges are becoming an increasingly popular way to sell advertisement slots on the internet. An ad exchange is basically a spot market for ad impressions. A publisher who has already signed contracts reserving advertisement impressions on his pages can choose between assigning a new ad impression for a new page view to a contracted advertiser or to sell it at an ad exchange. This leads to an online revenue maximization problem for the publisher. Given a new impression to sell decide whe...

  4. Two AdS2 branes in the euclidean AdS3

    We compute the density of open strings stretching between AdS2 branes in the euclidean AdS3. This is done by solving the factorization constraint of a degenerate boundary field, and the result is checked by a Cardy-type computation. We mention applications to branes in the minkowskian AdS3 and its cigar coset. (author)

  5. Two AdS2 branes in the Euclidean AdS3

    Ribault, S

    2003-01-01

    We compute the density of open strings stretching between AdS2 branes in the Euclidean AdS3. This is done by solving the factorization constraint of a degenerate boundary field, and the result is checked by a Cardy-type computation. We mention applications to branes in the Minkowskian AdS3 and its cigar coset.

  6. AdS solutions through transgression

    We present new classes of explicit supersymmetric AdS3 solutions of type IIB supergravity with non-vanishing five-form flux and AdS2 solutions of D=11 supergravity with electric four-form flux. The former are dual to two-dimensional SCFTs with (0,2) supersymmetry and the latter to supersymmetric quantum mechanics with two supercharges. We also investigate more general classes of AdS3 solutions of type IIB supergravity and AdS2 solutions of D=11 supergravity which in addition have non-vanishing three-form flux and magnetic four-form flux, respectively. The construction of these more general solutions makes essential use of the Chern-Simons or ''transgression'' terms in the Bianchi identity or the equation of motion of the field strengths in the supergravity theories. We construct infinite new classes of explicit examples and for some of the type IIB solutions determine the central charge of the dual SCFTs. The type IIB solutions with non-vanishing three-form flux that we construct include a two-torus, and after two T-dualities and an S-duality, we obtain new AdS3 solutions with only the NS fields being non-trivial. (orig.)

  7. Polarised Black Holes in AdS

    Costa, Miguel S; Oliveira, Miguel; Penedones, João; Santos, Jorge E

    2015-01-01

    We consider solutions in Einstein-Maxwell theory with a negative cosmological constant that asymptote to global $AdS_{4}$ with conformal boundary $S^{2}\\times\\mathbb{R}_{t}$. At the sphere at infinity we turn on a space-dependent electrostatic potential, which does not destroy the asymptotic $AdS$ behaviour. For simplicity we focus on the case of a dipolar electrostatic potential. We find two new geometries: (i) an $AdS$ soliton that includes the full backreaction of the electric field on the $AdS$ geometry; (ii) a polarised neutral black hole that is deformed by the electric field, accumulating opposite charges in each hemisphere. For both geometries we study boundary data such as the charge density and the stress tensor. For the black hole we also study the horizon charge density and area, and further verify a Smarr formula. Then we consider this system at finite temperature and compute the Gibbs free energy for both $AdS$ soliton and black hole phases. The corresponding phase diagram generalizes the Hawkin...

  8. Baby Skyrmions in AdS

    Elliot-Ripley, Matthew; Winyard, Thomas

    2015-01-01

    We study the baby Skyrme model in a pure AdS background without a mass term. The tail decays and scalings of massless radial solutions are demonstrated to take a similar form to those of the massive flat space model, with the AdS curvature playing a similar role to the flat space pion mass. We also numerically find minimal energy solutions for a range of higher topological charges and find that they form concentric ring-like solutions. Popcorn transitions (named in analogy with studies of toy...

  9. Current status of AdS instability

    CERN. Geneva

    2016-01-01

    arXiv:1403.6471 and thoroughly developed in arXiv:1407.6273. On the other hand the negative cosmological constant allows for the existence of stable, time-periodic, asymptotically AdS solutions of Einstein equations [arXiv:1303.3186].

  10. Eternal Black Holes in AdS

    Maldacena, Juan M.

    2001-01-01

    We propose a dual non-perturbative description for maximally extended Schwarzschild Anti-de-Sitter spacetimes. The description involves two copies of the conformal field theory associated to the AdS spacetime and an initial entangled state. In this context we also discuss a version of the information loss paradox and its resolution.

  11. AdS braneworld with Backreaction

    Bilić Neven; Tupper Gary

    2013-01-01

    We review the tachyon model derived from the dynamics of a 3-brane moving in the AdS5 bulk. The bulk geometry is based on the Randall-Sundrum II model extended to include the radion. The effective tachyon Lagrangian is modified due to the back-reaction of the brane on the bulk geometry.

  12. AdS braneworld with Backreaction

    Bilic, Neven

    2014-01-01

    We review the tachyon model derived from the dynamics of a 3-brane moving in the AdS5 bulk. The bulk geometry is based on the Randall-Sundrum II model extended to include the radion. The effective tachyon Lagrangian is modified due to the back-reaction of the brane on the bulk geometry.

  13. Superradiant instability in AdS

    Ganchev, Bogdan

    2016-01-01

    The phenomenon of superradiance in the context of asymptotically global AdS spacetimes is investigated with particular accent on its effect on the stability of the systems under consideration. To this end, the concept of an asymptotically AdS spacetime is explained, together with its implications on the boundary conditions at $\\mathcal{I}$, as well as the Newman-Penrose-Teukolsky formalism, whereby the Teukolsky master equation in a most general form for Kerr-AdS is given. Furthermore, work done in the cases of RN-AdS and Kerr-AdS is laid out in a concise manner, putting emphasis on the important steps taken in determining the endpoint of the superradiant instability in the two configurations. For the former this turns out to be a black hole with reduced charge and a static charged scalar condensate around it, whereas for the latter two of the more probable outcomes are presented, both of which imply a violation of one of the cosmic censorships.

  14. Instability corners in AdS space

    Dimitrakopoulos, Fotios V; Lippert, Matthew; Yang, I-Sheng

    2014-01-01

    We investigate whether arbitrarily small perturbations in global AdS space are generically unstable and collapse into black holes on the time scale set by gravitational interactions. We argue that current evidence, combined with our analysis, strongly suggests that a set of nonzero measure in the space of initial conditions does not collapse on this time scale. On the other hand, existing results do not provide an equally strong indication whether the unstable solutions also form a set of nonzero measure. We perform an analysis in position space to address this puzzle, and our formalism allows us to directly address the vanishing-amplitude limit. We show that gravitational self-interaction leads to tidal deformations which are equally likely to focus or defocus energy, and we sketch the phase diagram accordingly. We also clarify the connection between gravitational evolution in global AdS and holographic thermalization.

  15. Baby Skyrmions in AdS

    Elliot-Ripley, Matthew

    2015-01-01

    We study the baby Skyrme model in a pure AdS background without a mass term. The tail decays and scalings of massless radial solutions are demonstrated to take a similar form to those of the massive flat space model, with the AdS curvature playing a similar role to the flat space pion mass. We also numerically find minimal energy solutions for a range of higher topological charges and find that they form concentric ring-like solutions. Popcorn transitions (named in analogy with studies of toy models of holographic QCD) from an n layer to an n+1-layer configuration are observed at topological charges 9 and 27 and further popcorn transitions for higher charges are predicted. Finally, a point-particle approximation for the model is derived and used to successfully predict the ring structures and popcorn transitions for higher charge solitons.

  16. Boson Stars in AdS

    Buchel, Alex; Lehner, Luis

    2013-01-01

    We construct boson stars in global Anti de Sitter (AdS) space and study their stability. Linear perturbation results suggest that the ground state along with the first three excited state boson stars are stable. We evolve some of these solutions and study their nonlinear stability in light of recent work \\cite{Bizon:2011gg} arguing that a weakly turbulent instability drives scalar perturbations of AdS to black hole formation. However evolutions suggest that boson stars are nonlinearly stable and immune to the instability for sufficiently small perturbation. Furthermore, these studies find other families of initial data which similarly avoid the instability for sufficiently weak parameters. Heuristically, we argue that initial data families with widely distributed mass-energy distort the spacetime sufficiently to oppose the coherent amplification favored by the instability. From the dual CFT perspective our findings suggest that there exist families of rather generic initial conditions in strongly coupled CFT ...

  17. Conformal Mass in AdS gravity

    Jatkar, Dileep P; Miskovic, Olivera; Olea, Rodrigo

    2014-01-01

    We show that the Ashtekar-Magnon-Das (AMD) mass and other conserved quantities are equivalent to the Kounterterm charges in the asymptotically AdS spacetimes that satisfy the Einstein equations, if we assume the same asymptotic fall-off behavior of the Weyl tensor as considered by AMD. This therefore implies that, in all dimensions, the conformal mass can be directly derived from the bulk action and the boundary terms, which are written in terms of the extrinsic curvature.

  18. Antimicrobial Analysis of an Antiseptic Made from Ethanol Crude Extracts of P. granatum and E. uniflora in Wistar Rats against Staphylococcus aureus and Staphylococcus epidermidis

    Thaís Honório Lins Bernardo; Regina Célia Sales Santos Veríssimo; Valter Alvino; Maria Gabriella Silva Araujo; Raíssa Fernanda Evangelista Pires dos Santos; Max Denisson Maurício Viana; Maria Lysete de Assis Bastos; Magna Suzana Alexandre-Moreira; João Xavier de Araújo-Júnior

    2015-01-01

    Introduction. Surgical site infection remains a challenge for hospital infection control, especially when it relates to skin antisepsis in the surgical site. Objective. To analyze the antimicrobial activity in vivo of an antiseptic from ethanol crude extracts of P. granatum and E. uniflora against Gram-positive and Gram-negative bacteria. Methods. Agar drilling and minimal inhibitory tests were conducted for in vitro evaluation. In the in vivo bioassay were used Wistar rats and Staphylococcus...

  19. Aroma compounds in fresh cut pomegranate arils.

    Little published information exists regarding flavor and aroma compounds in pomegranate (Punica granatum). Although arils have fruity and sweet characteristics, we found no publications describing actual compounds responsible for their typical flavor. Since most commercial usage of pomegranates in...

  20. Augmentation and Evaluation of a Parasitoid, Encarsia inaron, and a Predator, Clitostethus arcuatus, for Biological Control of the Pomegranate Whitefly, Siphoninus phillyreae

    The pomegranate whitefly, Siphoninus phillyreae (Haliday) (Homoptera: Aleyrodidae), attacks at least 60 plant species of economic importance including pomegranate (Punica granatum), apple (Malus domestica), pear (Pyrus communis) and ash trees (Fraxinus spp.). A study was conducted to evaluate the b...

  1. Environ: E00495 [KEGG MEDICUS

    Full Text Available E00495 Punica granatum bark or root bark Granati cortex Gratati radix cortex Crude drug Pelletie...rine [CPD:C06182], Isopelletierine, Methylpelletierine [CPD:C06184], Methylisopelletierine, Pseudopelletie

  2. Refined holographic entanglement entropy for the AdS solitons and AdS black holes

    We consider the refinement of the holographic entanglement entropy for the holographic dual theories to the AdS solitons and AdS black holes, including the corrected ones by the Gauss–Bonnet term. The refinement is obtained by extracting the UV-independent piece of the holographic entanglement entropy, the so-called renormalized entanglement entropy which is independent of the choices of UV cutoff. Our main results are: (i) the renormalized entanglement entropies of the AdSd+1 soliton for d=4,5 are neither monotonically decreasing along the RG flow nor positive-definite, especially around the deconfinement/confinement phase transition; (ii) there is no topological entanglement entropy for AdS5 soliton even with Gauss–Bonnet correction; (iii) for the AdS black holes, the renormalized entanglement entropy obeys an expected volume law at IR regime, and the transition between UV and IR regimes is a smooth crossover even with Gauss–Bonnet correction; (iv) based on AdS/MERA conjecture, we postulate that the IR fixed-point state for the non-extremal AdS soliton is a trivial product state

  3. Predicting AD conversion

    Liu, Yawu; Mattila, Jussi; Ruiz, Miguel �ngel Mu�oz;

    2013-01-01

    To compare the accuracies of predicting AD conversion by using a decision support system (PredictAD tool) and current research criteria of prodromal AD as identified by combinations of episodic memory impairment of hippocampal type and visual assessment of medial temporal lobe atrophy (MTA) on MRI...

  4. Winding Strings in AdS_3

    Minces, P; Minces, Pablo; Nunez, Carmen

    2006-01-01

    Correlation functions of one-unit spectral flowed states in string theory on AdS_3 are considered. We present a formalism which allows to explicitly find the modified Knizhnik-Zamolodchikov and null vector equations to be satisfied by amplitudes of states in w=1 sectors. We give a precise prescription to solve this system of linear differential equations in cases that are relevant to obtain three and four point functions involving spectral flowed string states. We specifically compute three point functions with two and three one-unit spectral flowed operators and also discuss four point functions.

  5. Probing crunching AdS cosmologies

    Kumar, S. Prem; Vaganov, Vladislav

    2016-02-01

    Holographic gravity duals of deformations of CFTs formulated on de Sitter spacetime contain FRW geometries behind a horizon, with cosmological big crunch singularities. Using a specific analytically tractable solution within a particular single scalar truncation of {N}=8 supergravity on AdS4, we first probe such crunching cosmologies with spacelike radial geodesics that compute spatially antipodal correlators of large dimension boundary operators. At late times, the geodesics lie on the FRW slice of maximal expansion behind the horizon. The late time two-point functions factorise, and when transformed to the Einstein static universe, they exhibit a temporal non-analyticity determined by the maximal value of the scale factor ã max. Radial geodesics connecting antipodal points necessarily have de Sitter energy Ɛ ≲ ã max, while geodesics with Ɛ > ã max terminate at the crunch, the two categories of geodesics being separated by the maximal expansion slice. The spacelike crunch singularity is curved "outward" in the Penrose diagram for the deformed AdS backgrounds, and thus geodesic limits of the antipodal correlators do not directly probe the crunch. Beyond the geodesic limit, we point out that the scalar wave equation, analytically continued into the FRW patch, has a potential which is singular at the crunch along with complex WKB turning points in the vicinity of the FRW crunch. We then argue that the frequency space Green's function has a branch point determined by ã max which corresponds to the lowest quasinormal frequency.

  6. Adding Flavor to AdS4/CFT3

    Ammon, Martin; Meyer, Rene; O'Bannon, Andy; Wrase, Timm

    2009-01-01

    Aharony, Bergman, Jafferis, and Maldacena have proposed that the low-energy description of multiple M2-branes at a C4/Zk singularity is a (2+1)-dimensional N=6 supersymmetric U(Nc) x U(Nc) Chern-Simons matter theory, the ABJM theory. In the large-Nc limit, its holographic dual is supergravity in AdS4 x S7/Zk. We study various ways to add fields that transform in the fundamental representation of the gauge groups, i.e. flavor fields, to the ABJM theory. We work in a probe limit and perform analyses in both the supergravity and field theory descriptions. In the supergravity description we find a large class of supersymmetric embeddings of probe flavor branes. In the field theory description, we present a general method to determine the couplings of the flavor fields to the fields of the ABJM theory. We then study four examples in detail: codimension-zero N=3 supersymmetric flavor, described in supergravity by Kaluza-Klein monopoles or D6-branes; codimension-one N=(0,6) supersymmetric chiral flavor, described by...

  7. Holography of AdS vacuum bubbles

    We consider the fate of AdS vacua connected by tunneling events. A precise holographic dual of thin-walled Coleman-de Luccia bounces is proposed in terms of Fubini instantons in an unstable CFT. This proposal is backed by several qualitative and quantitative checks, including the precise calculation of the instanton action appearing in evaluating the decay rate. Big crunches manifest themselves as time dependent processes which reach the boundary of field space in a finite time. The infinite energy difference involved is identified on the boundary and highlights the ill-defined nature of the bulk setup. We propose a qualitative scenario in which the crunch is resolved by stabilizing the CFT, so that all attempts at crunching always end up shielded from the boundary by the formation of black hole horizons. In all these well defined bulk processes the configurations have the same asymptotics and are finite energy excitations.

  8. Twistor methods for AdS$_5$

    Adamo, Tim; Williams, Jack

    2016-01-01

    We consider the application of twistor theory to five-dimensional anti-de Sitter space. The twistor space of AdS$_5$ is the same as the ambitwistor space of the four-dimensional conformal boundary; the geometry of this correspondence is reviewed for both the bulk and boundary. A Penrose transform allows us to describe free bulk fields, with or without mass, in terms of data on twistor space. Explicit representatives for the bulk-to-boundary propagators of scalars and spinors are constructed, along with twistor action functionals for the free theories. Evaluating these twistor actions on bulk-to-boundary propagators is shown to produce the correct two-point functions.

  9. Probing crunching AdS cosmologies

    Kumar, S Prem

    2015-01-01

    Holographic gravity duals of deformations of CFTs formulated on de Sitter spacetime contain FRW geometries behind a horizon, with cosmological big crunch singularities. Using a specific analytically tractable solution within a particular single scalar truncation of N=8 supergravity on AdS_4, we first probe such crunching cosmologies with spacelike radial geodesics that compute spatially antipodal correlators of large dimension boundary operators. At late times, the geodesics lie on the FRW slice of maximal expansion behind the horizon. The late time two-point functions factorise, and when transformed to the Einstein static universe, they exhibit a temporal non-analyticity determined by the maximal value of the scale factor a_{max} . Radial geodesics connecting antipodal points necessarily have de Sitter energy E \\leq a_{max}, while geodesics with E > a_{max} terminate at the crunch, the two categories of geodesics being separated by the maximal expansion slice. The spacelike crunch singularity is curved "outw...

  10. AdS3: the NHEK generation

    Bena, Iosif; Heurtier, Lucien; Puhm, Andrea

    2016-05-01

    It was argued in [1] that the five-dimensional near-horizon extremal Kerr (NHEK) geometry can be embedded in String Theory as the infrared region of an infinite family of non-supersymmetric geometries that have D1, D5, momentum and KK monopole charges. We show that there exists a method to embed these geometries into asymptotically- {AdS}_3× {S}^3/{{Z}}_N solutions, and hence to obtain infinite families of flows whose infrared is NHEK. This indicates that the CFT dual to the NHEK geometry is the IR fixed point of a Renormalization Group flow from a known local UV CFT and opens the door to its explicit construction.

  11. ADS National Programmes: India

    Initial preliminary studies in India on ADS concepts were aimed toward applications such as, one way coupled booster reactor concept, thorium burner concept, enhancement of breeding rate of thorium– fueled fast reactors, and to incinerate Pu and minor actinides discharged from heavy water and fast reactors. These studies led to a roadmap on development of ADS subsystems in India, which was chalked out initially in June 2001. It was realized in these studies that the most challenging subsystem in terms of technology development and capital investment for ADS in India would be the high intensity proton accelerator, and that it must be accomplished in phased manner. Of the two alternative accelerator types, viz. the cyclotron and linear accelerator (linac), it is concluded that only linac would provide the necessary intense beam current for ADS applications. The energy amplifier (EA) scheme, with lead (45.5%) bismuth (55.5%) eutectic (LBE) as target & coolant, which was proposed in the early nineties would be one of the desired configurations of ADS for Indian applications. Additionally, subcritical reactor core of Indian Advanced Heavy Water Reactor (AHWR), with advantages of its low fission power density, and neutron economy is also a candidate among various ADS reactor configurations. These options of ADS configurations for thorium utilization are based on the neutronic properties of 233U isotope as fissile fuel, which are more or less similar in thermal and in moderately fast neutron spectra

  12. Gedunin and photogedunin of Xylocarpus granatum show significant anti-secretory effects and protect the gastric mucosa of peptic ulcer in rats.

    Lakshmi, V; Singh, N; Shrivastva, S; Mishra, S K; Dharmani, P; Mishra, V; Palit, G

    2010-07-01

    In the present study, the gastroprotective mechanism of Xylocarpus granatum fruit and its active constituents gedunin and photogedunin was investigated. Chloroform fraction (Fr-CHCl(3)) of X. granatum fruit was evaluated against cold restraint (CRU), aspirin (AS), alcohol (AL) and pyloric ligation (PL) induced gastric ulcer models in rats and histamine (HA) induced duodenal ulcer model in guinea pigs. Potential anti-ulcer activity of Fr-CHCl(3) was observed against CRU (58.28%), AS (67.81%), AL (84.38%), PL (65.66%) and HA (61.93%) induced ulcer models. The standard drug omeprazole (10mg/kg, p.o.) showed 68.25% protection against CRU, 57.08% against AS and 69.42% against PL model and 70.79% against HA induced duodenal ulcer. Sucralfate, another standard drug (500 mg/kg, p.o.) showed 62.72% protection in AL induced ulcer model. Fr-CHCl(3) significantly reduced free acidity (51.42%), total acidity (30.76%) and upregulated mucin secretion by 58.37% respectively. Phytochemical investigations of Fr-CHCl(3) yielded gedunin (36%), photogedunin (2%). Further, Fr-CHCl(3) and its compounds gedunin and photogedunin significantly inhibited H(+) K(+)-ATPase activity in vitro with IC(50) of 89.37, 56.86 and 66.54 microg/ml respectively as compared to the IC(50) value of omeprazole (30.24 microg/ml) confirming their anti-secretory activity. Conclusively, Fr-CHCl(3) of Xylocarpus granatum was found to possess anti-ulcerogenic activity which might be due to its anti-secretory activity and subsequent strengthening of the defensive mechanism. This study is the first of its kind to show significant anti-secretory effect of gedunin and photogedunin. Therefore it could act as a potent therapeutic agent against peptic ulcer disease. PMID:19962286

  13. Study on the Dyeing of Silk Fabrics with Granatum Pigment%石榴色素用于真丝织物染色的研究

    唐孝明; 黄继红; 张淑云; 赵春梅

    2012-01-01

    探讨了真丝织物用石榴色素的染色过程,并以K/S值为主要依据确定了最佳工艺,测试了染色真丝织物的色牢度和增重率。得到了石榴色素用于真丝织物最佳的染色工艺:石榴色素提取物浓度20g/L,染色温度70℃,染色时间60min,pH为5,浴比1:40;结果表明:石榴色素用于真丝织物染色,可以得到较好的染色效果;并且可使真丝增重率达2.00%。%The dyeing course of silk fiber fabrics with granatum pigment was investigated, according to the K/S value, the optimal processes were confirmed, and the color fastness and weight gain rate of dyed fabrics were tested. The optimum conditions are defined as follows, the concentration 20g/L of granatum pigment extracts, dyeing temperature 70℃, dyeing time 60 min , pH value 5,liquor ratio 1: 40, The results showed that the good effect was achieved after dyeing with granatum pigment, and the weight gain rate of the dyed silk was 2.0%.

  14. Pengaruh Variasi Volume Sari Buah Delima (Punica granacum) dengan Air Nira terhadap Kadar Gula, Vitamin C dan Kadar Serat pada Pembuatan Nata De Arenga dengan Menggunakan Acetobbacter xylinum

    Ningsih, Supiya

    2016-01-01

    The effect of pomegranate juice (Punica granacum) for sugar, vitamin C and fiber content in making nata de arenga has been done using Acetobacter xylinum. The determination of fibe applied by the method of defatting and degastion. Determination of the levels of vitamin C applied with iodometric titration method and the determination of glucose applied by the method line eynon. The highest fiber content contained in the ratio of 50:50 was 93,14%. The levels of vitamin C was also presented in a...

  15. Antiproton-Decelerator (AD)

    Laurent Guiraud

    1998-01-01

    When the Low-Energy Antiproton Ring (LEAR) was stopped in 1996, because of its costly operation, a cheaper way of continuing low-energy antiproton physics was sought. The Antiproton-Collector (AC), added in 1987 to the Antiproton Accumulator (AA) to provide a tenfold intensity increase, was converted into the Antiproton-Decelerator (AD). Antiprotons from the target at 3.5 GeV/c are decelerated to 100 MeV/c, and fast-ejected to the experiments. Major changes were necessary. Above all, the conversion from a constant-field machine to one with a magnetic cycle, modulating the field by an impressive factor 35. New systems for stochastic and electron cooling had to be added. Beam diagnostics at an intensity of only 2E7 antiprotons was a challenge. In 2000, the AD began delivery of antiprotons to the experiments.

  16. Value Adding Management

    Jensen, Per Anker; Katchamart, Akarapong

    2011-01-01

    Purpose: To investigate how Facilities Management (FM) can add value and develop a management concept that can assist facilities managers in implementing value adding strategies and practices. Theory: The study is based on the management model for FM included in the European FM standards, recent...... theories on added value of FM and real estate and the related concept of Value Management from building projects. The study is related to the EuroFM research group on The Added Value of FM. Design/methodology/approach: The study outlines a preliminary theoretical based management concept, which...... is investigated, tested and discussed based on a case study of an international corporation. Findings: The study shows that the management model for FM creates a relevant starting point but also that stakeholder and relationship management is an essential aspect of Value Adding Management. The case study confirms...

  17. Coopetitive Ad Auctions

    Hoy, Darrell; Jain, Kamal; Wilkens, Christopher A.

    2012-01-01

    A single advertisement often benefits many parties, for example, an ad for a Samsung laptop benefits Microsoft. We study this phenomenon in search advertising auctions and show that standard solutions, including the status quo ignorance of mutual benefit and a benefit-aware Vickrey-Clarke-Groves mechanism, perform poorly. In contrast, we show that an appropriate first-price auction has nice equilibria in a single-slot ad auction --- all equilibria that satisfy a natural cooperative envy-freen...

  18. AdS_3: the NHEK generation

    Bena, Iosif; Puhm, Andrea

    2015-01-01

    It was argued in arXiv:1203.4227 that the five-dimensional near-horizon extremal Kerr (NHEK) geometry can be embedded in String Theory as the infrared region of an infinite family of non-supersymmetric geometries that have D1, D5, momentum and KK monopole charges. We show that there exists a method to embed these geometries into asymptotically-AdS_3 x S^3/Z_N solutions, and hence to obtain infinite families of flows whose infrared is NHEK. This indicates that the CFT dual to the NHEK geometry is the IR fixed point of a Renormalization Group flow from a known local UV CFT and opens the door to its explicit construction.

  19. Hadronization at the AdS wall

    We describe hadronization events, using the AdS/CFT Correspondence, which display many of the qualitative features expected in QCD. In particular we study the motion of strings with separating end points in a back-reacted hard wall geometry. The solutions show the development of a linear QCD-like string. The end points oscillate in the absence of string breaking. We introduce string breaking by hand and evolve the new state forward in time to observe the separation of two string segments. A kink associated with this breaking evolves to the end points of the string inducing rho meson production. We explicitly compute the rho meson production at the end point.

  20. AdS backgrounds from black hole horizons

    We utilize the classification of IIB horizons with 5-form flux to present a unified description for the geometry of AdSn, n = 3, 5, 7 solutions. In particular, we show that all such backgrounds can be constructed from eight-dimensional 2-strong Calabi–Yau geometries with torsion which admit some additional isometries. We explore the geometry of AdS3 and AdS5 solutions but we do not find AdS7 solutions. (paper)

  1. ADS National Programmes: Italy

    Following a preliminary design developed in 1998, based on the Energy Amplifier concept proposed by CERN, a first configuration of a lead-bismuth Eutectic cooled Experimental ADS (LBE-XADS) was worked out in the period 1999–2001, under the aegis of MURST, by a group of Italian organizations led by Ansado Nucleare, with the aim of assessing the feasibility of a small sized (80 MWth) ADS. At the end of 1997 a joint effort of ENEA (National Agency for New Technology, Energy and the Environment) and INFN (National Institute for Nuclear Physics) led to the approval of a national programme by MURST (Minister for University and Scientific and Technological Research) named TRASCO (TRAsmutazione SCOrie) aiming at the study of physics and technologies needed to design an ADS for radioactive waste transmutation. The programme consisted of research subprogrammes on accelerator, neutronics, thermalhydraulics analysis, beam window technology, and material technology and compatibility with Pb and Pb-Bi. At now, most of the activities in support to the ADS development carried out at national level are part of EU-funded Projects. These activities are complemented by the programme agreement (AdP -Accordo di programma), signed between ENEA and the Ministry of Economic Development, which provides in general a range of activities aimed at the development of sustainable nuclear fission systems. Several universities and the national industry are involved, besides ENEA, in the activities

  2. Value Adding Management

    Jensen, Per Anker; Katchamart, Akarapong

    2011-01-01

    Purpose: To investigate how Facilities Management (FM) can add value and develop a management concept that can assist facilities managers in implementing value adding strategies and practices. Theory: The study is based on the management model for FM included in the European FM standards, recent...... impacts and strategic importance of FM for organisations and can be a practical tool for facilities managers in implementing value adding strategies and practices....... investigated, tested and discussed based on a case study of an international corporation. Findings: The study shows that the management model for FM creates a relevant starting point but also that stakeholder and relationship management is an essential aspect of Value Adding Management. The case study confirms...

  3. ADS National Programmes: China

    In China the conceptual study of an ADS concept which lasted for about five years ended in 1999. As one project of the National Basic Research Programme of China (973 Programme) in energy domain, which is sponsored by the China Ministry of Science and Technology (MOST), a five year programme of fundamental research of ADS physics and related technology was launched in 2000 and passed national review at the end of 2005. From 2007, another five year 973 Programme Key Technology Research of Accelerator Driven Subcritical System for Nuclear waste Transmutation started. The research activities were focused on HPPA physics and technology, reactor physics of external source driven subcritical assembly, nuclear data base and material study. For HPPA, a high current injector consisting of an ECR ion source, LEBT and an RFQ accelerating structure of 3.5 MeV has been built and were being improved. In reactor physics study, a series of neutron multiplication experimental study has been carrying out. The VENUS I facility has been constructed as the basic experimental platform for neutronics study in ADS blanket. VENUS I a zero power subcritical neutron multiplying assembly driven by external neutron produced by a pulsed neutron generator or 252Cf neutron source. The theoretical, experimental and simulation studies on nuclear data, material properties and nuclear fuel circulation related to ADS are carried out in order to provide the database for ADS system analysis. China Institute of Atomic Energy (CIAE), Institute of High Energy Physics (IHEP) and other Chinese institutes carried out the MOST project together. Besides CIAE, China Academy of Science (CAS) pays more and more attention to Advanced Nuclear Fuel Cycles (ANFC). A large programme of ANFC, including ADS and Th based nuclear fuel cycle, has been launched by CAS

  4. Dynamic ad hoc networks

    Rashvand, Habib

    2013-01-01

    Motivated by the exciting new application paradigm of using amalgamated technologies of the Internet and wireless, the next generation communication networks (also called 'ubiquitous', 'complex' and 'unstructured' networking) are changing the way we develop and apply our future systems and services at home and on local, national and global scales. Whatever the interconnection - a WiMAX enabled networked mobile vehicle, MEMS or nanotechnology enabled distributed sensor systems, Vehicular Ad hoc Networking (VANET) or Mobile Ad hoc Networking (MANET) - all can be classified under new networking s

  5. ADS National Programmes: Belgium

    The Belgian activities in the field of Accelerator Driven Systems (ADS) are mainly related to the MYRRHA project development. MYRRHA is an accelerator driven, multi purpose fast neutron spectrum facility for R&D, cooled by a lead-bismuth eutectic. SCK•CEN has started the MYRRHA project as a national programme with several national & international bilateral collaboration agreements; the project has now evolved as an European integrated project in the frame of the IPEUROTRANS (European Commission, Sixth Framework Programme). The MYRRHA ‘Draft-2’ predesign file (completed in the early 2005) has been proposed to the partners as a basis for the XT-ADS machine. After a detailed investigation of potential alternatives, the MYRRHA concept (for the subcritical core, the primary coolant system, the accommodation of experimental rigs, the reactor vessel and the spallation target) has been kept with some modifications to achieve the XT-ADS objectives. The most recent version of the XT-ADS design was presented in the 2007 TWG meeting

  6. ADS National Programmes: Japan

    In Japan, the research and development (R&D) activities on partitioning and transmutation (P&T) technology had been promoted under the OMEGA programme since 1988. The main institutes involved in these activities were the Japan Atomic Energy Research Institute (JAERI), the Japan Nuclear Cycle Development Institute (JNC), and the Central Research Institute of Electric Power Industry (CRIEPI). Among these institutes, JAERI had mainly conducted the R&D on ADS. In 1999 and 2000, the Atomic Energy Commission (AEC) of Japan implemented the check and review (C&R) on the P&T technology, and the ADS was considered as one of candidates for transmutation systems together with fast reactors. In 2005, JAERI and JNC were merged and the Japan Atomic Energy Agency (JAEA) was established. In JAEA, the R&D activities on both ADS and fast reactors have been continued. In August, 2008, the AEC of Japan launched the Technical Subcommittee on P&T Technology under the Advisory Committee on R&D, and conducted the discussion about the current state of the art concerning P&T technology in Japan and the future R&D programme. The Subcommittee issued the final report in April, 2009. The final report covered the impact of the P&T technology, the state of the art of the technology, evaluation on the progress of the R&D, and the recommendations of the future R&D. As the basic policy on the P&T technology, the report stated that the R&D should not aim at only the improvement of the P&T performance, but at the achievement of the requirements for whole performance of nuclear power generation. This means that the performance of the Double strata fuel cycle concept should be evaluated from viewpoints of safety, economy, environmental friendliness, saving resource, and non-proliferation of the first stratum as well as those of the second stratum. The Double strata concept, therefore, should be studied as a part of the whole nuclear system both in the transient phase of LWR to FBR and the equilibrium

  7. Management job ads

    Holmgreen, Lise-Lotte

    2014-01-01

    jobs by discursively constructing job ads that appeal to both sexes. This argument is part of the broader field of corporate social responsibility, corporate citizenship, and stakeholder management, which involves discussions of the obligations of corporations to acknowledge and mitigate the......The article asks whether it is not the responsibility of corporations to address the issue of women being underrepresented in Danish management jobs. In other words, it is argued that corporations should be encouraged to engage more actively in the recruitment of both men and women for management...... increasingly widespread impact that their activities have on communities and social structures. The article emphasises the need for more active engagement on the part of corporations by analysing the discursive construction of preferred candidates in a small sample of Danish management job ads. By means of...

  8. Adding linear orders

    Shelah, Saharon

    2011-01-01

    We address the following question: Can we expand an NIP theory by adding a linear order such that the expansion is still NIP? Easily, if acl(A)=A for all A, then this is true. Otherwise, we give counterexamples. More precisely, there is a totally categorical theory for which every expansion by a linear order has IP. There is also an \\omega-stable NDOP theory for which every expansion by a linear order interprets bounded arithmetic.

  9. ADS National Programmes: France

    Studies related to nuclear reactors and radioactive waste started at the French National Centre for Scientific research, CNRS, as a result of the French law on radioactive waste that was published in 1991. They were initially organized around the programme PACE (Physique pour l’Aval du Cycle Electronucléaire = physics of the back end of the nuclear fuel cycle), which became PACEN (Physique pour l’Aval du Cycle et production d’Energie Nucléaire = Physics of the back end of the nuclear fuel cycle and production of nuclear energy) in 2006. Research on accelerator driven systems was from the beginning part of this programme. This research is mainly funded by the National Institute for Nuclear end Particle Physics (IN2P3) of CNRS and within the EURATOM European programmes (FP5, 6 and 7). The programme took place in several stages, and covered various scientific fields, benefitting from expertise of CNRS in the field. More specifically, it aimed and still aims to: – Test and verify the feasibility and design of the ADS concept, in terms of neutronics, physics of materials, design of the accelerator and tests of its prototypical components that have been built (or are at present under construction); – Measure and-or improve nuclear data related to radioactive waste transmutation. Today, most of the activities in support to ADS development carried out by CNRS focus on accelerator developments, GUINEVERE (Generator of Uninterrupted Intense NEutron at the lead VEnus REactor) experiment, ADS core studies, deployment scenarios and nuclear data measurements. The CEA R&D programmes on ADS are mainly focused on the European project EUROTRANS of the 6th Framework programme (2005–2010) and continued in the FREYA project of the 7th Framework Programme

  10. AdS 3-manifolds and Higgs bundles

    Alessandrini, Daniele; Li, Qiongling

    2015-01-01

    In this paper we investigate the relationships between closed AdS 3-manifolds and Higgs bundles. We have a new way to construct AdS structures that allows us to see many of their properties explicitly, for example we can recover the very recent formula by Tholozan for the volumes. We also find...

  11. Evaporation of large black holes in AdS

    The AdS/CFT correspondence offers a new perspective on the long-standing black hole information paradox. However, to be able to use the available gauge/gravity machinery one is forced to consider so-called 'large' black holes in AdS, and these objects are thermodynamically stable - they do not evaporate. We describe a simple toy model that allows large AdS black holes to decay, by coupling the emitted radiation to an external scalar field propagating in an auxiliary space. This effectively changes the properties of the boundary of AdS, making it partly absorbing. We demonstrate that the evaporation process never ceases by explicitly presenting (a) the transmission coefficient for a wave scattering from the bulk into auxiliary space and (b) the greybody factor for a black 3-brane in an AdS background. Therefore, the model provides an interesting framework to address the information paradox using AdS/CFT techniques.

  12. The effect of Ad

    李小艳

    2010-01-01

    There is the trend that now people appreciate those who are slim and regard slim even thin people beautiful. The thinner a person is, the more beautiful. Women, born to pursuit beauty, try various means to follow the trend. We all watch TV, and find a lot of advertisements on diet. The effect of them is tremendous. We all know the fact that it is not at all the better mouse trap will catch mouse. The sales methods are more important. If an advertisement is very interesting and seemingly effective, people will be lured by the ad and then try some of the products.

  13. Eating ad Libitum

    Hillersdal, Line

    in the context of the 'ad libitum meal'. The analytical interest is thus what kind of eaters and bodies are enacted in the meal test and what ideas of prevention and treatment are embedded in their standards. Drawing from ongoing empirical work among Danish obesity researchers performing scientific...... producing an eater who: ”shouldn't restrain herself”. Practices of food and eating in the test meal I suggest, will allow us to tackle reductionism by showing the complex cultural context shaping clinical intervention....

  14. Dirac operator on fuzzy AdS2

    In this article we construct the chirality and Dirac operators on fuzzy AdS2. We also derive the discrete spectrum of the Dirac operator which is important in the study of the spectral triple associated to AdS2. It is shown that the degeneracy of the spectrum present in the commutative AdS2 is lifted in the noncommutative case. The way we construct the chirality operator is suggestive of how to introduce the projector operators of the corresponding projective modules on this space. (author)

  15. Dirac Operator on Noncommutative AdS_2

    Fakhri, H

    2003-01-01

    In this article we construct the chirality and Dirac operators on noncommutative AdS_2. We also derive the discrete spectrum of the Dirac operator which is important in the study of the spectral triple associated with AdS_2. It is shown that the degeneracy of the spectrum present in the commutative AdS_2 is lifted in the noncommutative case. The way we construct the chirality operator is suggestive of how to introduce the projector operators of the corresponding projective modules on this space.

  16. Dirac operator on fuzzy AdS2

    Fakhri, Hossein; Imaanpur, Ali

    2003-03-01

    In this article we construct the chirality and Dirac operators on noncommutative AdS2. We also derive the discrete spectrum of the Dirac operator which is important in the study of the spectral triple associated to AdS2. It is shown that the degeneracy of the spectrum present in the commutative AdS2 is lifted in the noncommutative case. The way we construct the chirality operator is suggestive of how to introduce the projector operators of the corresponding projective modules on this space.

  17. Dirac Operator on Fuzzy AdS_2

    H. Fakhri; Imaanpur, A.

    2003-01-01

    In this article we construct the chirality and Dirac operators on noncommutative AdS_2. We also derive the discrete spectrum of the Dirac operator which is important in the study of the spectral triple associated with AdS_2. It is shown that the degeneracy of the spectrum present in the commutative AdS_2 is lifted in the noncommutative case. The way we construct the chirality operator is suggestive of how to introduce the projector operators of the corresponding projective modules on this space.

  18. Radius-dependent gauge unification in AdS5

    Choi, Kiwoon; Kim, Hyung Do; Kim, Ian-Woo

    2002-01-01

    We examine the relation of the 4-dimensional low energy coupling of bulk gauge boson in a slice of AdS5 to the 5-dimensional fundamental couplings as a function of the orbifold radius R. This allows us to address the gauge coupling unification in AdS5 by means of the radius running as well as the conventional momentum running. We then compute the radius dependence of 1-loop low energy couplings in generic AdS5 theory with 4-dimensional supersymmetry, and discuss the low energy predictions whe...

  19. Open Strings on AdS_2 Branes

    Lee, Peter; Ooguri, Hirosi; Park, Jongwon; Tannenhauser, Jonathan

    2001-01-01

    We study the spectrum of open strings on AdS_2 branes in AdS_3 in an NS-NS background, using the SL(2,R) WZW model. When the brane carries no fundamental string charge, the open string spectrum is the holomorphic square root of the spectrum of closed strings in AdS_3. It contains short and long strings, and is invariant under spectral flow. When the brane carries fundamental string charge, the open string spectrum again contains short and long strings in all winding sectors. However, branes w...

  20. Thermodynamics of Asymptotically Locally AdS Spacetimes

    Papadimitriou, I; Papadimitriou, Ioannis; Skenderis, Kostas

    2005-01-01

    We formulate the variational problem for AdS gravity with Dirichlet boundary conditions and demonstrate that the covariant counterterms are necessary to make the variational problem well-posed. The holographic charges associated with asymptotic symmetries are then rederived via Noether's theorem and `covariant phase space' techniques. This allows us to prove the first law of black hole mechanics for general asymptotically locally AdS black hole spacetimes. We illustrate our discussion by computing the conserved charges and verifying the first law for the four dimensional Kerr-Newman-AdS and the five dimensional Kerr-AdS black holes.

  1. Killing spinors and supersymmetry on AdS

    In this paper we construct several supersymmetric theories on AdS5 background. We discuss the proper definition of the Killing equation for the symplectic Majorana spinors required in AdS5 supersymmetric theories. We find that the symplectic Killing spinor equation involves a matrix M in the USp(2N) indices whose role was not recognized previously. Using the correct Killing spinors we explicitly confirm that the particle masses in the constructed theories agree with the predictions of the AdS/CFT correspondence. Finally, we establish correct O(d - 1,2) isometry transformations required to keep the Lagrangian invariant on AdSd

  2. Conical singularities in AdS space time

    Full text: In recent years, the study of conformal gauge theories from 10-D has been motivated by the AdSd+1/CFTd correspondence, first conjectured by J. Maldacena. The aim of this work is to consider the d = 4 case by analysing the configuration of the N coincident D3 branes. In this context, the work shows that there is a duality between type IIB string theory in AdS5 x S5 and N = 4 SU(N) Super Yang-Mills Theory in the IR. The AdS5/CFT4 correspondence brought also new approaches to the strong coupling problem in QCD. Nowadays, there is a whole line of works that focus on the low dimensional correspondence AdS4/CFT3, like the application to graphene and topological insulators, and the AdS3/CFT2 correspondence, related with the entanglement entropy. In this work, we consider the vortex configuration solution to the AdS4 and AdS3 space-time. The most important motivation is to discuss the boundary theory resulting from these solutions. We have examined a straightforward approach to a holographic computation of the graphene and entanglement entropy in the presence of the conical singularity. After this analysis, we consider the scalar field in the bulk in the presence of this metrics and work out the compactification modes. Taking the holographic point of view, we study and discuss the resulting Green function. (author)

  3. Wireless Ad Hoc Networks

    Hong-Chuan Yang

    2007-01-01

    Full Text Available We study the energy-efficient configuration of multihop paths with automatic repeat request (ARQ mechanism in wireless ad hoc networks. We adopt a cross-layer design approach and take both the quality of each radio hop and the battery capacity of each transmitting node into consideration. Under certain constraints on the maximum tolerable transmission delay and the required packet delivery ratio, we solve optimization problems to jointly schedule the transmitting power of each transmitting node and the retransmission limit over each hop. Numerical results demonstrate that the path configuration methods can either significantly reduce the average energy consumption per packet delivery or considerably extend the average lifetime of the multihop route.

  4. Thermodynamics of large AdS black holes

    We consider leading order quantum corrections to the geometry of large AdS black holes in a spherical reduction of four-dimensional Einstein gravity with negative cosmological constant. The Hawking temperature grows without bound with increasing black hole mass, yet the semiclassical back-reaction on the geometry is relatively mild, indicating that observers in free fall outside a large AdS black hole never see thermal radiation at the Hawking temperature. The positive specific heat of large AdS black holes is a statement about the dual gauge theory rather than an observable property on the gravity side. Implications for string thermodynamics with an AdS infrared regulator are briefly discussed

  5. Supersymmetric Kaluza-Klein reductions of AdS backgrounds

    Figueroa-O'Farrill, J M; Farrill, Jos\\'e Figueroa-O'; Sim\\'on, Joan

    2004-01-01

    This paper contains a classification of smooth Kaluza--Klein reductions (by one-parameter subgroups) of the maximally supersymmetric anti de Sitter backgrounds of supergravity theories. We present a classification of one-parameter subgroups of isometries of anti de Sitter spaces, discuss the causal properties of their orbits on these manifolds, and discuss their action on the space of Killing spinors. We analyse the problem of which quotients admit a spin structure. We then apply these results to write down the list of smooth everywhere spacelike supersymmetric quotients of AdS_3 x S^3 (x R^4), AdS_4 x S^7, AdS_5 x S^5 and AdS_7 x S^4, and the fraction of supersymmetry preserved by each quotient. The results are summarised in tables which should be useful on their own. The paper also includes a discussion of supersymmetry of singular quotients.

  6. ADS National Programmes: Netherlands

    The ADS related activities within the Netherlands are concentrated at NRG. From 2000 to 2006, NRG supported SCK•CEN in their development of MYRRHA. The support was mainly devoted to Computational Fluid Dynamics (CFD) simulations for the windowless target option. This collaboration was prolonged within the framework of the EU FP6 EUROTRANS project. Eventually this lead to a solution strategy for the hydraulic (without heat transfer) evaluation of a windowless target with one free surface using an Eulerian-Eulerian modeling approach. As a second free surface was added to the target design later, this approach would need to be revisited. The developed approach was applied to an assess the feasibility of a three feeder windowless target design. This preliminary assessment confirmed that there were no serious show stoppers for a three feeder design. Another study undertaken using related to the windowless target was a preliminary assessment of the risk of lead-bismuth splashing in case of a sudden heat deposition by the beam, e.g. at beam startup or beam interuptions. Within the framework of the EU FP7 CDT project, a window target is currently being assessed thermalhydraulicly in collaboration with SCK•CEN. Within the EU FP5 ASCHLIM project, the state of the art with regard to turbulence modelling for CFD approaches was determined. It was concluded that accurate simulation of heat transport in HLM was not feasible, especially in natural or mixed convection regimes. Within the EU FP7 THINS project this issue is currently being treated. NRG assists the commercial CFD code vendor CD adapco in implementing and testing a promising, academically tested, algebraic heat flux model

  7. Chaos and hydrodynamics near AdS$_2$

    Jensen, Kristan

    2016-01-01

    We revisit AdS$_2$ holography with the Sachdev-Ye-Kitaev models in mind. Our main result is to rewrite a generic theory of gravity near an AdS$_2$ throat as a novel hydrodynamics coupled to the correlation functions of a conformal quantum mechanics. This gives a prescription for the computation of $n$-point functions in the dual quantum mechanics. We thereby find that the dual is maximally chaotic.

  8. Minisuperspace limit of the AdS3 WZNW model

    Ribault, Sylvain

    2009-01-01

    We derive the three-point function of the AdS3 WZNW model in the minisuperspace limit by Wick rotation from the H3+ model. The result is expressed in terms of Clebsch-Gordan coefficients of the Lie algebra sl(2,R). We also introduce a covariant basis of functions on AdS3, which can be interpreted as bulk-boundary propagators.

  9. ADS National Programmes: Belarus

    The Belarus activities in the field of Accelerator Driven Systems (ADS) are mainly related to the investigations performed at the subcritical facility YALINA. Yalina is a zero power subcritical facility to study neutronics of ADS and the transmutation reaction rates. The first assembly YALINA-T was put into operation in 2000. YALINA-T is a multiplying system (kmax<0.98), located inside a graphite reflector of parallelepiped configuration that is arranged of high purity reactor graphite blocks. The core of the assembly is of parallelepiped configuration too and consists of bare polyethylene subassemblies where fuel rods of EK-10 type (UO2 of 10% enrichment by U235) are located. At the core center a neutron producing Pb target is located that reminds fuel subassembly by shape and size. Graphite reflector is covered from outside by Cd. At the distances R=50 mm, 100 mm, 150 mm from the core center three experimental channels (D=25 mm) are situated for location of samples of radioactive targets and various detectors for measurement of neutron flux density functionals. For the same purpose two axial channels (D=25 mm) are located in graphite reflector at the distances 250 mm and 358 mm; by Z=H/2 one more radial channel (D=25 mm) is located. YALINA-B core is arranged of rectangular parallelepipeds too. The fast (booster) zone consists of lead subassemblies, the thermal one of polyethylene subassemblies. Central part of the booster zone, containing highly enriched (90%) metallic uranium fuel and Pb target is encased into a separate stainless steel frame. The absorber zone is located at the outer boundary of the booster zone. It consists of inner layer of rods with metallic natural uranium fixed in lead blocks, as in the previous cases, and of an outer layer of rods filled by boron carbide powder, B4C. Boron carbide rods are located in the same lattice as the uranium fuel pins in the booster zone with pin pitch 16.00 mm. This absorber zone enables fast neutrons to

  10. Discrimination in Online Ad Delivery

    Sweeney, Latanya

    2013-01-01

    A Google search for a person's name, such as "Trevon Jones", may yield a personalized ad for public records about Trevon that may be neutral, such as "Looking for Trevon Jones?", or may be suggestive of an arrest record, such as "Trevon Jones, Arrested?". This writing investigates the delivery of these kinds of ads by Google AdSense using a sample of racially associated names and finds statistically significant discrimination in ad delivery based on searches of 2184 racially associated person...

  11. Complexity Growth for AdS Black Holes

    Cai, Rong-Gen; Wang, Shao-Jiang; Yang, Run-Qiu; Peng, Rong-Hui

    2016-01-01

    We further investigate the Complexity-Action (CA) duality conjecture for stationary anti de-Sitter (AdS) black holes and derive some exact results for the growth rate of action within Wheeler-DeWitt (WDW) patch at late time approximation, which is dual to the growth rate of quantum complexity of holographic state. Based on the results from the general $D$-dimensional Reissner-Nordstr\\"{o}m (RN)-AdS black hole, rotating/charged Ba\\~{n}ados-Teitelboim-Zanelli (BTZ) black hole, Kerr-AdS black hole and charged Gauss-Bonnet-AdS black hole, we present a new complexity bound but leave unchanged the conjecture that the stationary AdS black hole in Einstein gravity is the fastest computer in nature.

  12. Constructing the AdS dual of a Fermi liquid: AdS Black holes with Dirac hair

    \\vCubrović, Mihailo; Schalm, Koenraad

    2010-01-01

    We provide new evidence that the holographic dual to a strongly coupled charged Fermi Liquid has a non-zero fermion density in the bulk. We show that the pole-strength of the stable quasiparticle characterizing the Fermi surface is encoded in the spatially averaged AdS probability density of a single normalizable fermion wavefunction in AdS. Recalling Migdal's theorem which relates the pole strength to the Fermi-Dirac characteristic discontinuity in the number density at $\\ome_F$, we conclude that the AdS dual of a Fermi liquid is described by occupied on-shell fermionic modes in AdS. Encoding the occupied levels in the total probability density of the fermion field directly, we show that an AdS Reissner-Nordstr\\"{o}m black hole in a theory with charged fermions has a critical temperature, at which the system undergoes a first-order transition to a black hole with a non-vanishing profile for the bulk fermion field. Thermodynamics and spectral analysis confirm that the solution with non-zero AdS fermion-profil...

  13. ADS National Programmes: Germany

    The German R&D programme for ADS development is related to the partitioning and transmutation of spent fuel. This programme is implemented mainly by the three national research centres belonging to the Helmholtz Association, i.e. Karlsruhe Institute of Technology (KIT), Forschungszentrum Jülich (FZJ) in cooperation with the Technical University of Aachen (RWTH Aachen) and the Helmholtz Zentrum Dresden Rossendorf (HZDR). The main purpose of this R&D programme is the prospect to manage the high level radioactive waste such as to reduce the burden on a final repository. P&T does not eliminate the need for a final repository whatever the strategy, but it allows the reduction of the radio-toxicity associated with radioactive waste, the increase of the repository capacity as a consequence of the reduction of masses to be stored and their associated residual heat load. Different fuel cycle scenarios to implement P&T can be envisaged. These scenarios have been evaluated to identify the impact of P&T on the characteristics, number and deployment pace of the installations of the fuel cycle (reprocessing, fuel fabrication, storage etc). Almost all activities conducted in the R&D programme are embedded in European and international projects and initiatives. In the following more details on the relevant components of the R&D programme are summarized

  14. AdS-Carroll Branes

    Clark, T E

    2016-01-01

    Coset methods are used to determine the action of a co-dimension one brane (domain wall) embedded in (d+1)-dimensional AdS space in the Carroll limit in which the speed of light goes to zero. The action is invariant under the non-linearly realized symmetries of the AdS-Carroll spacetime. The Nambu-Goldstone field exhibits a static spatial distribution for the brane with a time varying momentum density related to the brane's spatial shape as well as the AdS-C geometry. The AdS-C vector field dual theory is obtained.

  15. Logarithmic AdS waves and Zwei-Dreibein gravity

    We show that the parameter space of Zwei-Dreibein Gravity (ZDG) in AdS3 exhibits critical points, where massive graviton modes coincide with pure gauge modes and new ‘logarithmic’ modes appear, similar to what happens in New Massive Gravity. The existence of critical points is shown both at the linearized level, as well as by finding AdS wave solutions of the full non-linear theory, that behave as logarithmic modes towards the AdS boundary. In order to find these solutions explicitly, we give a reformulation of ZDG in terms of a single Dreibein, that involves an infinite number of derivatives. At the critical points, ZDG can be conjectured to be dual to a logarithmic conformal field theory with zero central charges, characterized by new anomalies whose conjectured values are calculated

  16. Asymptotically AdS spacetimes with a timelike Kasner singularity

    Ren, Jie

    2016-07-01

    Exact solutions to Einstein's equations for holographic models are presented and studied. The IR geometry has a timelike cousin of the Kasner singularity, which is the less generic case of the BKL (Belinski-Khalatnikov-Lifshitz) singularity, and the UV is asymptotically AdS. This solution describes a holographic RG flow between them. The solution's appearance is an interpolation between the planar AdS black hole and the AdS soliton. The causality constraint is always satisfied. The entanglement entropy and Wilson loops are discussed. The boundary condition for the current-current correlation function and the Laplacian in the IR is examined. There is no infalling wave in the IR, but instead, there is a normalizable solution in the IR. In a special case, a hyperscaling-violating geometry is obtained after a dimensional reduction.

  17. Null warped AdS in higher spin gravity

    Breunhoelder, Veronika; Grumiller, Daniel; Prohazka, Stefan

    2015-01-01

    We equip three-dimensional spin-3 gravity in the principal embedding with a new set of boundary conditions that we call "asymptotically null warped AdS". We find a chiral copy of the Polyakov-Bershadsky algebra as asymptotic symmetry algebra, reminiscent of the situation in topologically massive gravity with strict null warped AdS boundary conditions. We prove the invertibility of the map between zuvielbein and metric variables and construct a global gauge transformation to half of AdS spin-3 gravity in the diagonal embedding. This explains why the theory is chiral and why the Polyakov-Bershadsky algebra arises. We then introduce chemical potentials, derive the entropy, free energy, and the holographic response functions, and conclude with a discussion.

  18. Branes in the euclidean AdS3

    In this work we propose an exact microscopic description of maximally symmetric branes in a euclidean AdS3 background. As shown by Bachas and Petropoulos, the most important such branes are localized along a euclidean AdS2 is contained in AdS3. We provide explicit formulas for the coupling of closed strings to such branes (boundary states) and for the spectral density of open strings. The latter is computed in two different ways first in terms of the open string reflection amplitude and then also from the boundary states by world-sheet duality. This gives rise to an important Cardy type consistency check. All the results are compared in detail with the geometrical picture. We also discuss a second class of branes with spherical symmetry and finally comment on some implications for D-branes in a 2D back hole geometry. (author)

  19. New Massive Gravity and AdS4 Counterterms

    We show that the recently proposed Dirac-Born-Infeld extension of new massive gravity emerges naturally as a counterterm in four-dimensional anti-de Sitter space (AdS4). The resulting on-shell Euclidean action is independent of the cutoff at zero temperature. We also find that the same choice of counterterm gives the usual area law for the AdS4 Schwarzschild black hole entropy in a cutoff-independent manner. The parameter values of the resulting counterterm action correspond to a c=0 theory in the context of the duality between AdS3 gravity and two-dimensional conformal field theory. We rewrite this theory in terms of the gauge field that is used to recast 3D gravity as a Chern-Simons theory.

  20. Detailed ultraviolet asymptotics for AdS scalar field perturbations

    Evnin, Oleg

    2016-01-01

    We present a range of methods suitable for accurate evaluation of the leading asymptotics for integrals of products of Jacobi polynomials in limits when the degrees of some or all polynomials inside the integral become large. The structures in question have recently emerged in the context of effective descriptions of small amplitude perturbations in anti-de Sitter (AdS) spacetime. The limit of high degree polynomials corresponds in this situation to effective interactions involving extreme short-wavelength modes, whose dynamics is crucial for the turbulent instabilities that determine the ultimate fate of small AdS perturbations. We explicitly apply the relevant asymptotic techniques to the case of a self-interacting probe scalar field in AdS and extract a detailed form of the leading large degree behavior, including closed form analytic expressions for the numerical coefficients appearing in the asymptotics.

  1. All AdS7 solutions of type II supergravity

    In M-theory, the only AdS7 supersymmetric solutions are AdS7×S4 and its orbifolds. In this paper, we find and classify new supersymmetric solutions of the type AdS7×M3 in type II supergravity. While in IIB none exist, in IIA with Romans mass (which does not lift to M-theory) there are many new ones. We use a pure spinor approach reminiscent of generalized complex geometry. Without the need for any Ansatz, the system determines uniquely the form of the metric and fluxes, up to solving a system of ODEs. Namely, the metric on M3 is that of an S2 fibered over an interval; this is consistent with the Sp(1) R-symmetry of the holographically dual (1,0) theory. By including D8 brane sources, one can numerically obtain regular solutions, where topologically M3≅S3

  2. Entanglement entropy for free scalar fields in AdS

    Sugishita, Sotaro

    2016-01-01

    We compute entanglement entropy for free massive scalar fields in anti-de Sitter (AdS) space. The entangling surface is a minimal surface whose boundary is a sphere at the boundary of AdS. The entropy can be evaluated from the thermal free energy of the fields on a topological black hole by using the replica method. In odd-dimensional AdS, exact expressions of the Renyi entropy S_n are obtained for arbitrary n. We also evaluate 1-loop corrections coming from the scalar fields to holographic entanglement entropy. Applying the results, we compute the leading difference of entanglement entropy between two holographic CFTs related by a renormalization group flow triggered by a double trace deformation. The difference is proportional to the shift of a central charge under the flow.

  3. New massive gravity and AdS(4) counterterms.

    Jatkar, Dileep P; Sinha, Aninda

    2011-04-29

    We show that the recently proposed Dirac-Born-Infeld extension of new massive gravity emerges naturally as a counterterm in four-dimensional anti-de Sitter space (AdS(4)). The resulting on-shell Euclidean action is independent of the cutoff at zero temperature. We also find that the same choice of counterterm gives the usual area law for the AdS(4) Schwarzschild black hole entropy in a cutoff-independent manner. The parameter values of the resulting counterterm action correspond to a c=0 theory in the context of the duality between AdS(3) gravity and two-dimensional conformal field theory. We rewrite this theory in terms of the gauge field that is used to recast 3D gravity as a Chern-Simons theory. PMID:21635026

  4. Towards integrability for AdS3/CFT2

    We review the recent progress towards applying worldsheet integrability techniques to the AdS3/CFT2 correspondence to find its all-loop S matrix and Bethe–Yang equations. We study in full detail the massive sector of AdS3×S3×T4 superstrings supported by pure Ramond–Ramond (RR) fluxes. The extension of this machinery to accommodate massless modes, to the AdS3×S3×S3×S1 pure-RR background and to backgrounds supported by mixed background fluxes is also reviewed. While the results discussed here were found elsewhere, our presentation sometimes deviates from the one found in the original literature in an effort to be pedagogical and self-contained. (topical review)

  5. Logarithmic conformal field theories and AdS correspondence

    Khorrami, A. M. Ghezelbash. M.; Aghamohammadi, A

    1998-01-01

    We generalize the Maldacena correspondence to the logarithmic conformal field theories. We study the correspondence between field theories in (d+1)-dimensional AdS space and the d-dimensional logarithmic conformal field theories in the boundary of $AdS_{d+1}$. Using this correspondence, we get the n-point functions of the corresponding logarithmic conformal field theory in d-dimensions.

  6. AdS black holes as reflecting cavities

    We use the identification between null singularities of correlators in the bulk with time singularities in the boundary correlators to study the analytic structure of time-dependent thermal Green functions using the eikonal approximation for classical solutions in the AdS black hole background. We show that the location of singularities in complex time can be understood in terms of null rays bouncing on the boundaries and singularities of the eternal black hole, giving the picture of a 'reflecting cavity'. We can then extract the general analytic expression for the asymptotic values of the frequencies of quasinormal modes in large AdS black holes.

  7. AdS black holes as reflecting cavities

    Amado, Irene

    2008-01-01

    We use the identification between null singularities of correlators in the bulk with time singularities in the boundary correlators to study the analytic structure of time-dependent thermal Green functions using the eikonal approximation for classical solutions in the AdS black hole background. We show that the location of singularities in complex time can be understood in terms of null rays bouncing on the boundaries and singularities of the eternal black hole, giving the picture of a `reflecting cavity'. We can then extract the general analytic expression for the asymptotic values of the frequencies of quasinormal modes in large AdS black holes.

  8. Smoothed Transitions in Higher Spin AdS Gravity

    Banerjee, Shamik; Castro, Alejandra; Hellerman, Simeon; Hijano, Eliot; Lepage-Jutier, Arnaud; Maloney, Alexander; Shenker, Stephen

    2012-01-01

    We consider CFTs conjectured to be dual to higher spin theories of gravity in AdS_3 and AdS_4. Two dimensional CFTs with W_N symmetry are considered in the lambda=0 (k --> infinity) limit, where they are conjectured to be described by continuous orbifolds. The torus partition function is computed, using reasonable assumptions, and equals that of a free field theory. We find no phase transition at temperatures of order one; the usual Hawking-Page phase transition is removed by the highly degen...

  9. Small black holes in global AdS spacetime

    Jokela, Niko; Vuorinen, Aleksi

    2015-01-01

    We study finite temperature correlation functions and quasinormal modes in a strongly coupled conformal field theory holographically dual to a small black hole in global Anti-de Sitter spacetime. Upon variation of the black hole radius, our results smoothly interpolate between known limits corresponding to large black holes and thermal AdS space, implying that a non-Hermitian eigenvalue problem gets continuously transitioned into a Hermitian one. This provides justification for the use of small black holes as regulators in studies of black hole formation in global AdS spacetime.

  10. Phases of Global AdS Black Holes

    Basu, Pallab; Subramanian, P N Bala

    2016-01-01

    We study the phases of gravity coupled to a charged scalar and gauge field in an asymptotically Anti-de Sitter spacetime ($AdS_4$) in the grand canonical ensemble. For the conformally coupled scalar, an intricate phase diagram is charted out between the four relevant solutions: global AdS, boson star, Reissner-Nordstrom black hole and the hairy black hole. The nature of the phase diagram undergoes qualitative changes as the charge of the scalar is changed, which we discuss. We also discuss the new features that arise in the extremal limit.

  11. Phases of global AdS black holes

    Basu, Pallab; Krishnan, Chethan; Subramanian, P. N. Bala

    2016-06-01

    We study the phases of gravity coupled to a charged scalar and gauge field in an asymptotically Anti-de Sitter spacetime ( AdS 4) in the grand canonical ensemble. For the conformally coupled scalar, an intricate phase diagram is charted out between the four relevant solutions: global AdS, boson star, Reissner-Nordstrom black hole and the hairy black hole. The nature of the phase diagram undergoes qualitative changes as the charge of the scalar is changed, which we discuss. We also discuss the new features that arise in the extremal limit.

  12. Branes in AdS and pp-wave spacetimes

    Skenderis, K; Skenderis, Kostas; Taylor, Marika

    2002-01-01

    We find half supersymmetric AdS-embeddings in AdS_5 x S^5 corresponding to all quarter BPS orthogonal intersections of D3-branes with Dp-branes. A particular case is the Karch-Randall embedding AdS_4 x S^2. We explicitly prove that these embeddings are supersymmetric by showing that the kappa symmetry projections are compatible with half of the target space Killing spinors and argue that all these cases lead to AdS/dCFT dualities involving a CFT with a defect. We also find an asymptotically AdS_4 x S^2 embedding that corresponds to a holographic RG-flow on the defect. We then consider the pp-wave limit of the supersymmetric AdS-embeddings and show how it leads to half supersymmetric D-brane embeddings in the pp-wave background. We systematically analyze D-brane embeddings in the pp-wave background along with their supersymmetry. We construct all supersymmetric D-branes wrapped along the light-cone using operators in the dual gauge theory: the open string states are constructed using defect fields. We also fin...

  13. Positivity of energy for asymptotically locally AdS spacetimes

    Cheng, M C N; Cheng, Miranda C.N.; Skenderis, Kostas

    2005-01-01

    We derive necessary conditions for the spinorial Witten-Nester energy to be well-defined for asymptotically locally AdS spacetimes. We find that the conformal boundary should admit a spinor satisfying certain differential conditions and in odd dimensions the boundary metric should be conformally Einstein. We show that these conditions are satisfied by asymptotically AdS spacetimes. The gravitational energy (obtained using the holographic stress energy tensor) and the spinorial energy are equal in even dimensions and differ by a bounded quantity related to the conformal anomaly in odd dimensions.

  14. Perturbative entanglement thermodynamics for AdS spacetime: renormalization

    Mishra, Rohit; Singh, Harvendra

    2015-01-01

    We study the effect of charged excitations in the AdS spacetime on the first law of entanglement thermodynamics. It is found that `boosted' AdS black holes give rise to a more general form of first law which includes chemical potential and charge density. To obtain this result we have to resort to a second order perturbative calculation of entanglement entropy for small size subsystems. At first order the form of entanglement law remains unchanged even in the presence of charged excitations. ...

  15. Mixed-symmetry fields in AdS(5), conformal fields, and AdS/CFT

    Metsaev, R R

    2014-01-01

    Mixed-symmetry arbitrary spin massive, massless, and self-dual massive fields in AdS(5) are studied. Light-cone gauge actions for such fields leading to decoupled equations of motion are constructed. Light-cone gauge formulation of mixed-symmetry anomalous conformal currents and shadows in 4d flat space is also developed. AdS/CFT correspondence for normalizable and non-normalizable modes of mixed-symmetry AdS fields and the respective boundary mixed-symmetry anomalous conformal currents and shadows is studied. We demonstrate that the light-cone gauge action for massive mixed-symmetry AdS field evaluated on solution of the Dirichlet problem amounts to the light-cone gauge 2-point vertex of mixed-symmetry anomalous shadow. Also we show that UV divergence of the action for mixed-symmetry massive AdS field with some particular value of mass parameter evaluated on the Dirichlet problem amounts to the action of long mixed-symmetry conformal field, while UV divergence of the action for mixed-symmetry massless AdS fi...

  16. AdS (instability: Lessons from the scalar field

    Pallab Basu

    2015-06-01

    Full Text Available We argued in arXiv:1408.0624 that the quartic scalar field in AdS has features that could be instructive for answering the gravitational stability question of AdS. Indeed, the conserved charges identified there have recently been observed in the full gravity theory as well. In this paper, we continue our investigation of the scalar field in AdS and provide evidence that in the Two-Time Formalism (TTF, even for initial conditions that are far from quasi-periodicity, the energy in the higher modes at late times is exponentially suppressed in the mode number. Based on this and some related observations, we argue that there is no thermalization in the scalar TTF model within time-scales that go as ∼1/ϵ2, where ϵ measures the initial amplitude (with only low-lying modes excited. It is tempting to speculate that the result holds also for AdS collapse.

  17. Penrose inequality for asymptotically AdS spaces

    Itkin, Igor [Raymond and Beverly Sackler School of Physics and Astronomy, Tel-Aviv University, Tel-Aviv 69978 (Israel); Oz, Yaron, E-mail: yaronoz@post.tau.ac.il [Raymond and Beverly Sackler School of Physics and Astronomy, Tel-Aviv University, Tel-Aviv 69978 (Israel)

    2012-02-28

    In general relativity, the Penrose inequality relates the mass and the entropy associated with a gravitational background. If the inequality is violated by an initial Cauchy data, it suggests a creation of a naked singularity, thus providing means to consider the cosmic censorship hypothesis. We propose a general form of Penrose inequality for asymptotically locally AdS spaces.

  18. BRST Quantization of String Theory in AdS(3)

    Pakman, A

    2003-01-01

    We study the BRST quantization of bosonic and NSR strings propagating in AdS(3) x N backgrounds. The no-ghost theorem is proved using the Frenkel-Garland-Zuckerman method. Regular and spectrally-flowed representations of affine SL(2,R) appear on an equal footing. Possible generalizations to related curved backgrounds are discussed.

  19. Internet Advertising. Google AdWords versus Facebook Ads

    Paul PAŞCU

    2014-05-01

    Full Text Available This article describes how to use the applications for Internet advertising, Google AdWords and Facebook Ads. Our attempt is to present the advantages and disadvantages of each of them, the costs and benefits, a useful aspect for companies that plan to start advertising campaigns on the Internet.

  20. Entanglement temperature and perturbed AdS3 geometry

    Levine, G. C.; Caravan, B.

    2016-06-01

    Generalizing the first law of thermodynamics, the increase in entropy density δ S (x ) of a conformal field theory (CFT) is proportional to the increase in energy density, δ E (x ) , of a subsystem divided by a spatially dependent entanglement temperature, TE(x ) , a fixed parameter determined by the geometry of the subsystem, crossing over to thermodynamic temperature at high temperatures. In this paper we derive a generalization of the thermodynamic Clausius relation, showing that deformations of the CFT by marginal operators are associated with spatial temperature variations, δ TE(x ) , and spatial energy correlations play the role of specific heat. Using AdS/CFT duality we develop a relationship between a perturbation in the local entanglement temperature of the CFT and the perturbation of the bulk AdS metric. In two dimensions, we demonstrate a method through which direct diagonalizations of the boundary quantum theory may be used to construct geometric perturbations of AdS3 .

  1. AdS5 backgrounds with 24 supersymmetries

    Beck, S.; Gutowski, J.; Papadopoulos, G.

    2016-06-01

    We prove a non-existence theorem for smooth AdS 5 solutions with connected, compact without boundary internal space that preserve strictly 24 supersymmetries. In particular, we show that D = 11 supergravity does not admit such solutions, and that all such solutions of IIB supergravity are locally isometric to the AdS 5 × S 5 maximally supersymmetric background. Furthermore, we prove that (massive) IIA supergravity also does not admit such solutions, provided that the homogeneity conjecture for massive IIA supergravity is valid. In the context of AdS/CFT these results imply that if gravitational duals for strictly mathcal{N}=3 superconformal theories in 4-dimensions exist, they are either singular or their internal spaces are not compact.

  2. AdS5 Backgrounds with 24 Supersymmetries

    Beck, S W; Papadopoulos, G

    2016-01-01

    We prove a non-existence theorem for smooth AdS5 solutions with connected, compact without boundary internal space that preserve strictly 24 supersymmetries. In particular, we show that D=11 supergravity does not admit such solutions, and that all such solutions of IIB supergravity are locally isometric to the AdS_5 * S^5 maximally supersymmetric background. Furthermore, we prove that (massive) IIA supergravity also does not admit such solutions, provided that the homogeneity conjecture for massive IIA supergravity is valid. In the context of AdS/CFT these results imply that if strictly N=3 superconformal theories in 4-dimensions exist, their gravitational dual backgrounds are either singular or their internal spaces are not compact.

  3. The PredictAD project

    Antila, Kari; Lötjönen, Jyrki; Thurfjell, Lennart;

    2013-01-01

    objective of the PredictAD project was to find and integrate efficient biomarkers from heterogeneous patient data to make early diagnosis and to monitor the progress of AD in a more efficient, reliable and objective manner. The project focused on discovering biomarkers from biomolecular data...

  4. Self-dual warped AdS3 black holes

    Chen, Bin; Ning, Bo

    2010-12-01

    We study a new class of solutions of three-dimensional topological massive gravity. These solutions can be taken as nonextremal black holes, with their extremal counterparts being discrete quotients of spacelike warped AdS3 along the U(1)L isometry. We study the thermodynamics of these black holes and show that the first law is satisfied. We also show that for consistent boundary conditions, the asymptotic symmetry generators form only one copy of the Virasoro algebra with central charge cL=(4νℓ)/(G(ν2+3)), with which the Cardy formula reproduces the black hole entropy. We compute the real-time correlators of scalar perturbations and find a perfect match with the dual conformal field theory (CFT) predictions. Our study provides a novel example of warped AdS/CFT correspondence: the self-dual warped AdS3 black hole is dual to a CFT with nonvanishing left central charge. Moreover, our investigation suggests that the quantum topological massive gravity asymptotic to the same spacelike warped AdS3 in different consistent ways may be dual to different two-dimensional CFTs.

  5. String theory in AdS3 background

    In this thesis we study string theory in AdS3 background in the context of AdS/CFT correspondence. We discuss unitarity, modular invariance and closure of operator product expansion (OPE) in the theory. A construction of spacetime conformal field theory from worldsheet affine symmetry due to Giveon, Kutasov and Seiberg is presented. The spacetime CFT has the meaning boundary CFT in AdS/CFT correspondence. The knowledge of two dimensional N extended superconformal algebras is used to construct superstrings on AdS3 x N with extended spacetime supersymmetry. A classification of vacua of superstrings on AdS3 is proposed from the knowledge of superconformal algebras in two dimensions. We present some exact solutions of Kniznik-Zamolodochikov (KZ) equation for SL(2, R) WZNW model for four point functions, which have logarithmic singularities of conformally invariant cross ratios, from a simple ansatz. Some asymptotic solutions with logarithmic behaviour are also presented. We analyze the logarithmic solutions and show that they can give rise to logarithmic operators in the theory. It has been shown by OPE analysis and otherwise that representation with SL(2, R) quantum number j = -1/2 play a very special role. The possibility of contribution oj logarithmic operators to the OPE is discussed. We find that OPE can not close or unitary representations if we include the logarithmic operators in the theory. We discuss the implications of logarithmic operators about the unitarity of the theory. The role of singleton representation is clarified in the context of logarithmic operators in AdS/CFT correspondence. (author)

  6. Observing quantum gravity in asymptotically AdS space

    Emelyanov, Slava

    2015-12-01

    The question is studied of whether an observer can discover quantum gravity in the semiclassical regime. It is shown that it is indeed possible to probe a certain quantum gravity effect by employing an appropriately designed detector. The effect is related to the possibility of having topologically inequivalent geometries in the path-integral approach at the same time. A conformal field theory (CFT) state which is expected to describe the eternal anti-de Sitter (AdS) black hole in the large-N limit is discussed. It is argued under certain assumptions that the black hole boundary should be merely a patch of the entire AdS boundary. This leads then to a conclusion that that CFT state is the ordinary CFT vacuum restricted to that patch. If existent, the bulk CFT operators can behave as the ordinary semiclassical quantum field theory in the large-N limit in the weak sense.

  7. Smoothed transitions in higher spin AdS gravity

    We consider CFTs conjectured to be dual to higher spin theories of gravity in AdS3 and AdS4. Two-dimensional CFTs with WN symmetry are considered in the λ = 0 (k → ∞) limit where they are conjectured to be described by continuous orbifolds. The torus partition function is computed, using reasonable assumptions, and equals that of a free-field theory. We find no phase transition at temperatures of order 1; the usual Hawking–Page phase transition is removed by the highly degenerate light states associated with conical defect states in the bulk. Three-dimensional Chern–Simons matter CFTs with vector-like matter are considered on T3, where the dynamics is described by an effective theory for the eigenvalues of the holonomies. Likewise, we find no evidence for a Hawking–Page phase transition at a large level k. (paper)

  8. AdS nonlinear instability: moving beyond spherical symmetry

    Dias, Oscar J C

    2016-01-01

    Anti-de Sitter (AdS) is conjectured to be nonlinear unstable to a weakly turbulent mechanism that develops a cascade towards high frequencies, leading to black hole formation [1,2]. We give evidence that the gravitational sector of perturbations behaves differently from the scalar one studied in [2]. In contrast with [2], we find that not all gravitational normal modes of AdS can be nonlinearly extended into periodic horizonless smooth solutions of the Einstein equation. In particular, we show that even seeds with a single normal mode can develop secular resonances, unlike the spherically symmetric scalar field collapse studied in [2]. Moreover, if the seed has two normal modes, more than one resonance can be generated at third order, unlike the spherical collapse of [2]. We also show that weak turbulent perturbative theory predicts the existence of direct and inverse cascades, with the former dominating the latter for equal energy two-mode seeds.

  9. Ambitwistors, oscillators and massless fields on $AdS_5$

    Uvarov, D V

    2016-01-01

    Positive energy unitary irreducible representations of $SU(2,2)$ can be constructed with the aid of bosonic oscillators in (anti)fundamental representation of $SU(2)_L\\times SU(2)_R$ that are closely related to Penrose twistors. Starting with the correspondence between the doubleton representations, homogeneous functions on projective twistor space and on-shell $SL(2,\\mathbb C)$ generalized Weyl curvature spinors and their low-spin counterparts, we study in the similar way the correspondence between the massless representations, homogeneous functions on ambitwistor space and, via the Penrose transform, with the gauge fields on Minkowski boundary of $AdS_5$. The possibilities of reconstructing massless fields on $AdS_5$ and some applications are also discussed.

  10. The Mixed Phase of Charged AdS Black Holes

    Piyabut Burikham

    2016-01-01

    Full Text Available We study the mixed phase of charged AdS black hole and radiation when the total energy is fixed below the threshold to produce a stable charged black hole branch. The coexistence conditions for the charged AdS black hole and radiation are derived for the generic case when radiation particles carry charge. The phase diagram of the mixed phase is demonstrated for both fixed potential and charge ensemble. In the dual gauge picture, they correspond to the mixed phase of quark-gluon plasma (QGP and hadron gas in the fixed chemical potential and density ensemble, respectively. In the nuclei and heavy-ion collisions at intermediate energies, the mixed phase of exotic QGP and hadron gas could be produced. The mixed phase will condense and evaporate into the hadron gas as the fireball expands.

  11. Semiclassical Virasoro Blocks from AdS$_3$ Gravity

    Hijano, Eliot; Perlmutter, Eric; Snively, River

    2015-01-01

    We present a unified framework for the holographic computation of Virasoro conformal blocks at large central charge. In particular, we provide bulk constructions that correctly reproduce all semiclassical Virasoro blocks that are known explicitly from conformal field theory computations. The results revolve around the use of geodesic Witten diagrams, recently introduced in arXiv:1508.00501, evaluated in locally AdS$_3$ geometries generated by backreaction of heavy operators. We also provide an alternative computation of the heavy-light semiclassical block -- in which two external operators become parametrically heavy -- as a certain scattering process involving higher spin gauge fields in AdS$_3$; this approach highlights the chiral nature of Virasoro blocks. These techniques may be systematically extended to compute corrections to these blocks and to interpolate amongst the different semiclassical regimes.

  12. Semiclassical Virasoro blocks from AdS3 gravity

    Hijano, Eliot; Kraus, Per; Perlmutter, Eric; Snively, River

    2015-12-01

    We present a unified framework for the holographic computation of Virasoro conformal blocks at large central charge. In particular, we provide bulk constructions that correctly reproduce all semiclassical Virasoro blocks that are known explicitly from conformal field theory computations. The results revolve around the use of geodesic Witten diagrams, recently introduced in [1], evaluated in locally AdS3 geometries generated by backreaction of heavy operators. We also provide an alternative computation of the heavy-light semiclassical block — in which two external operators become parametrically heavy — as a certain scattering process involving higher spin gauge fields in AdS3; this approach highlights the chiral nature of Virasoro blocks. These techniques may be systematically extended to compute corrections to these blocks and to interpolate amongst the different semiclassical regimes.

  13. Perturbative entanglement thermodynamics for AdS spacetime: Renormalization

    Mishra, Rohit

    2015-01-01

    We study the effect of charged excitations in the AdS spacetime on the first law of entanglement thermodynamics. It is found that `boosted' AdS black holes give rise to a more general form of first law which includes chemical potential and charge density. To obtain this result we have to resort to a second order perturbative calculation of entanglement entropy for small size subsystems. At first order the form of entanglement law remains unchanged even in the presence of charged excitations. But the thermodynamic quantities have to be appropriately `renormalized' at the second order due to the corrections. We work in the perturbative regime where $T_{thermal}\\ll T_E$.

  14. Universal isolation in the AdS landscape

    Danielsson, U H; Vargas, S C

    2016-01-01

    We study the universal conditions for quantum non-perturbative stability against bubble nucleation for pertubatively stable AdS vacua based on positive energy theorems. We also compare our analysis with the pre-existing ones in the literature carried out within the thin-wall approximation. The aforementioned criterion is then tested in two explicit examples describing massive type IIA string theory compactified on $S^3$ and $S^3\\,\\times\\,S^3$, respectively. The AdS landscape of both classes of compactifications is known to consist of a set of isolated points. The main result is that all critical points respecting the Breitenlohner-Freedaman (BF) bound also turn out be stable at a non-perturbative level. Finally, we speculate on the possible universal features that may be extracted from the above specific examples.

  15. Supersymmetric AdS6 solutions of type IIB supergravity

    We study the general requirement for supersymmetric AdS6 solutions in type IIB supergravity. We employ the Killing spinor technique and study the differential and algebraic relations among various Killing spinor bilinears to find the canonical form of the solutions. Our result agrees precisely with the work of Apruzzi et al. (JHEP 1411:099, 2014), which used the pure spinor technique. Hoping to identify the geometry of the problem, we also computed four-dimensional theory through the dimensional reduction of type IIB supergravity on AdS6. This effective action is essentially a non-linear sigma model with five scalar fields parametrizing SL(3,ℝ)/SO(2,1), modified by a scalar potential and coupled to Einstein gravity in Euclidean signature. We argue that the scalar potential can be explained by a subgroup CSO(1,1,1) ⊂SL(3,ℝ) in a way analogous to gauged supergravity

  16. Supersymmetric AdS6 solutions of type IIB supergravity

    We study the general requirement for supersymmetric AdS6 solutions in type IIB supergravity. We employ the Killing spinor technique and study the differential and algebraic relations among various Killing spinor bilinears to find the canonical form of the solutions. Our result agrees precisely with the work of Apruzzi et al. (JHEP 1411:099, 2014), which used the pure spinor technique. Hoping to identify the geometry of the problem, we also computed four-dimensional theory through the dimensional reduction of type IIB supergravity on AdS6. This effective action is essentially a non-linear sigma model with five scalar fields parametrizing SL(3,R)/ SO(2,1), modified by a scalar potential and coupled to Einstein gravity in Euclidean signature. We argue that the scalar potential can be explained by a subgroup CSO(1,1,1) is contained in SL(3,R) in a way analogous to gauged supergravity. (orig.)

  17. One loop gauge couplings in AdS5

    Choi, Kiwoon; Kim, Ian-Woo

    2002-01-01

    We calculate the full 1-loop corrections to the low energy coupling of bulk gauge boson in a slice of AdS5 which are induced by generic 5-dimensional scalar, Dirac fermion, and vector fields with arbitrary Z_2 times Z_2' orbifold boundary conditions. In supersymmetric limit, our results correctly reproduce the results obtained by an independent method based on 4-dimensional effective supergravity. This provides a nontrivial check of our results and assures the regularization scheme-independen...

  18. Extended Superconformal Algebras on AdS_{3}

    Ito, Katsushi

    1998-01-01

    We study a supersymmetric extension of the Virasoro algebra on the boundary of the anti-de Sitter space-time AdS_{3}. Using the free field realization of the currents, we show that the world-sheet affine Lie superalgebras osp(1|2)^{(1)}, sl(1|2)^{(1)} and sl(2|2)^{(1)} provide the boundary N=1,2 and 4 extended superconformal algebras, respectively.

  19. Universal Kounterterms in Lovelock AdS gravity

    Kofinas, Georgios; Olea, Rodrigo

    2008-01-01

    We show the universal form of the boundary term (Kounterterm series) which regularizes the Euclidean action and background-independent definition of conserved quantities for any Lovelock gravity theory with AdS asymptotics (including Einstein-Hilbert and Einstein-Gauss-Bonnet). We discuss on the connection of this procedure to the existence of topological invariants and Chern-Simons forms in the corresponding dimensions.

  20. Mellin amplitudes for $AdS_5\\times S^5$

    Rastelli, Leonardo

    2016-01-01

    We revisit the calculation of holographic correlation functions in IIB supergravity on $AdS_5\\times S^5$. Results for four-point functions simplify drastically when expressed in Mellin space. We conjecture a compact formula for the four-point functions of one-half BPS singe-trace operators of arbitrary weight. Our methods rely on general consistency conditions and eschew detailed knowledge of the supergravity effective action.

  1. Spectrum and Statistical Entropy of AdS Black Holes

    Vaz, Cenalo; Wijewardhana, L. C. R.

    2009-01-01

    Popular approaches to quantum gravity describe black hole microstates differently and apply different statistics to count them. Since the relationship between the approaches is not clear, this obscures the role of statistics in calculating the black hole entropy. We address this issue by discussing the entropy of eternal AdS black holes in dimension four and above within the context of a midisuperspace model. We determine the black hole eigenstates and find that they describe the quantization...

  2. Alday-Maldacena duality and AdS Plateau problem

    Morozov, A.

    2008-01-01

    A short summary of approximate approach to the study of minimal surfaces in AdS, based on solving Nambu-Goto equations iteratively. Today, after partial denunciation of the BDS conjecture, this looks like the only constructive approach to understanding the ways of its possible modification and thus to saving the Alday-Maldacena duality. Numerous open technical problems are explicitly formulated throughout the text.

  3. Smooth Causal Patches for AdS Black Holes

    Raju, Suvrat

    2016-01-01

    We review the paradox of low energy excitations about an AdS black hole. An appropriately chosen unitary operator in the boundary theory can create a locally strong excitation near the black hole horizon, whose global energy is small as a result of the gravitational redshift. The paradox is that this seems to violate a general rule of statistical mechanics, which states that an operator with energy parametrically smaller than $k T$ cannot create a significant excitation in a thermal system. W...

  4. AdS sub 3 gravity and conformal field theories

    Behrndt, K; Gaida, I

    1999-01-01

    We present a detailed analysis of AdS sub 3 gravity, the BTZ black hole and the associated conformal field theories (CFTs). In particular we focus on the non-extreme six-dimensional string solution with background metric AdS sub 3 x S sup 3 near the horizon. In addition we introduce momentum modes along the string, corresponding to a BTZ black hole, and a Taub-NUT soliton in the transverse Euclidean space. We show that the AdS sub 3 space-time of this configuration has the spatial geometry of an annulus with a Liouville model at the outer boundary and a two-dimensional black hole at the inner boundary. These CFTs provide the dynamical degrees of freedom of the three-dimensional effective model and, together with the CFT corresponding to S sup 3 , provide a statistical interpretation of the corresponding Bekenstein-Hawking entropy. We test the proposed exact black hole entropy, which should hold to all orders in alpha', by an independent field theoretical analysis including higher-order curvature corrections. ...

  5. SUSY properties of warped AdS$_3$

    Jeong, Jaehoon; Yoshida, Kentaroh

    2014-01-01

    We examine supersymmetric properties of null-warped AdS$_3$, or alternatively Schrodinger geometries, dual to putative warped CFTs in two dimensions. We classify super Schrodinger subalgebras of the superalgebra psu(1, 1$|$2) $\\oplus$ psu(1, 1$|$2) , corresponding to the superconformal algebra of the AdS$_3 \\times$ S$^3$ geometry. We comment on geometric realisations and provide a string theory description with enhanced supersymmetry in terms of intersecting D3-branes. For type IIB supergravity solutions based on T$^{1,1}$, we consider the relationship between five-dimensional Schrodinger solutions and their three-dimensional null-warped counterparts, corresponding to R symmetry twists. Finally, we study a family of null-warped AdS$_3$ solutions in a setting where there is an ambiguity over the R symmetry and confirm that, for examples admitting a KK reduction to three dimensions, the minimisation of a real superpotential of the three-dimensional gauged supergravity captures the central charge and R symmetry.

  6. AdS Field Theory from Conformal Field Theory

    Fitzpatrick, A Liam

    2012-01-01

    We provide necessary and sufficient conditions for a Conformal Field Theory to have a description in terms of a perturbative Effective Field Theory in AdS. The first two conditions are well-known: the existence of a perturbative `1/N' expansion and an approximate Fock space of states generated by a finite number of low-dimension operators. We add a third condition, that the Mellin amplitudes of the CFT correlators must be well-approximated by functions that are bounded by a polynomial at infinity in Mellin space, or in other words, that the Mellin amplitudes have an effective theory-type expansion. We explain the relationship between our conditions and unitarity, and provide an analogy with scattering amplitudes that becomes exact in the flat space limit of AdS. The analysis also yields a simple connection between conformal blocks and AdS diagrams, providing a new calculational tool very much in the spirit of the S-Matrix program. We also begin to explore the potential pathologies associated with higher spin ...

  7. Ultraviolet asymptotics and singular dynamics of AdS perturbations

    Craps, Ben; Vanhoof, Joris

    2015-01-01

    Important insights into the dynamics of spherically symmetric AdS-scalar field perturbations can be obtained by considering a simplified time-averaged theory accurately describing perturbations of amplitude epsilon on time-scales of order 1/epsilon^2. The coefficients of the time-averaged equations are complicated expressions in terms of the AdS scalar field mode functions, which are in turn related to the Jacobi polynomials. We analyze the behavior of these coefficients for high frequency modes. The resulting asymptotics can be useful for understanding the properties of the finite-time singularity in solutions of the time-averaged theory recently reported in the literature. We highlight, in particular, the gauge dependence of this asymptotics, with respect to the two most commonly used gauges. The harsher growth of the coefficients at large frequencies in higher-dimensional AdS suggests strengthening of turbulent instabilities in higher dimensions. In the course of our derivations, we arrive at recursive rel...

  8. Entanglement Entropy and Duality in AdS(4)

    Bakas, Ioannis

    2015-01-01

    Small variations of the entanglement entropy \\delta S and the expectation value of the modular Hamiltonian \\delta E are computed holographically for circular entangling curves in the boundary of AdS(4), using gravitational perturbations with general boundary conditions in spherical coordinates. Agreement with the first law of thermodynamics, \\delta S = \\delta E, requires that the line element of the entangling curve remains constant. In this context, we also find a manifestation of electric-magnetic duality for the entanglement entropy and the corresponding modular Hamiltonian, following from the holographic energy-momentum/Cotton tensor duality.

  9. Internal Structure of Charged AdS Black Holes

    Bhattacharjee, Srijit; Virmani, Amitabh

    2016-01-01

    When an electrically charged black hole is perturbed its inner horizon becomes a singularity, often referred to as the Poisson-Israel mass inflation singularity. Ori constructed a model of this phenomenon for asymptotically flat black holes, in which the metric can be determined explicitly in the mass inflation region. In this paper we implement the Ori model for charged AdS black holes. We find that the mass function inflates faster than the flat space case as the inner horizon is approached. Nevertheless, the mass inflation singularity is still a weak singularity: although spacetime curvature becomes infinite, tidal distortions remain finite on physical objects attempting to cross it.

  10. The AdS3 central charge in string theory

    We evaluate the vacuum expectation value of the central charge operator in string theory in an AdS3 vacuum. Our calculation provides a rare non-zero one-point function on a spherical worldsheet. The evaluation involves the regularization both of a worldsheet ultraviolet divergence (associated to the infinite volume of the conformal Killing group), and a space-time infrared divergence (corresponding to the infinite volume of space-time). The two divergences conspire to give a finite result, which is the classical general relativity value for the central charge, corrected in bosonic string theory by an infinite series of tree level higher derivative terms.

  11. Small black holes in global AdS spacetime

    Jokela, Niko; Pönni, Arttu; Vuorinen, Aleksi

    2016-04-01

    We study the properties of two-point functions and quasinormal modes in a strongly coupled field theory holographically dual to a small black hole in global anti-de Sitter spacetime. Our results are seen to smoothly interpolate between known limits corresponding to large black holes and thermal AdS space, demonstrating that the Son-Starinets prescription works even when there is no black hole in the spacetime. Omitting issues related to the internal space, the results can be given a field theory interpretation in terms of the microcanonical ensemble, which provides access to energy densities forbidden in the canonical description.

  12. Self-Dual Warped AdS$_3$ Black Holes

    Chen, Bin; Ning, Bo

    2010-01-01

    We propose a new class of solutions of three-dimensional topological massive gravity. These solutions are non-extremal black holes, with their extremal counterparts being discrete quotients of spacelike warped AdS$_3$ along the $U(1)_L$ isometry. We study the thermodynamics of these black holes and show that the first law is satisfied. We also show that for consistent boundary conditions, the asymptotic symmetry generators form only one copy of the Virasoro algebra with central charge $c_L = \\frac{4\

  13. Thermal Fluctuations in a Charged AdS Black Hole

    Pourhassan, B

    2015-01-01

    In this paper, we will analyze the effects of thermal fluctuations on a charged AdS black hole. This will be done by analyzing the corrections to black hole thermodynamics due to these thermal fluctuations. We will demonstrate that the entropy of this black hole get corrected by logarithmic term. We will also calculate other corrections to other important thermodynamic quantities for this black hole. Finally, we will use the corrected value of the specific heat to analyze the phase transition in this system.

  14. Most general AdS_3 boundary conditions

    Grumiller, Daniel

    2016-01-01

    We consider the most general asymptotically anti-de Sitter boundary conditions in three-dimensional Einstein gravity with negative cosmological constant. The metric contains in total twelve independent functions, six of which are interpreted as chemical potentials (or non-normalizable fluctuations) and the other half as canonical boundary charges (or normalizable fluctuations). Their presence modifies the usual Fefferman-Graham expansion. The asymptotic symmetry algebra consists of two sl(2)_k current algebras, the levels of which are given by k=l/(4G_N), where l is the AdS radius and G_N the three-dimensional Newton constant.

  15. AdS Chern-Simons Gravity induces Conformal Gravity

    Aros, Rodrigo

    2013-01-01

    The leitmotif of this paper is the question of whether four- and higher even-dimensional Conformal Gravities do have a Chern-Simons pedigree. We show that Weyl gravity can be obtained as dimensional reduction of a five-dimensional Chern-Simons action for a suitable (gauged-fixed, tractor-like) five-dimensional AdS connection. The gauge-fixing and dimensional reduction program admits a readily generalization to higher dimensions for the case of certain conformal gravities obtained by contractions of the Weyl tensor.

  16. Fake gaps in AdS_3/CFT_2

    Belin, Alexandre; Hung, Ling-Yan

    2015-01-01

    We discuss properties of interpolating geometries in three dimensional gravity in the presence of a chiral anomaly. This anomaly, which introduces an unbalance between left and right central charges, is protected under RG flows. For this simple reason it is impossible to gap a system with such an anomaly. Our goal is to discuss how holography captures this basic and robust feature. We demonstrate the absence of a mass gap by analysing the linearized spectrum and holographic entanglement entropy of these backgrounds in the context of AdS$_3$/CFT$_2$.

  17. Internal Structure of Charged AdS Black Holes

    Bhattacharjee, Srijit(Astroparticle Physics & Cosmology Division, Saha Institute of Nuclear Physics, Kolkata, 700064, India); Sarkar, Sudipta; Virmani, Amitabh

    2016-01-01

    When an electrically charged black hole is perturbed its inner horizon becomes a singularity, often referred to as the Poisson-Israel mass inflation singularity. Ori constructed a model of this phenomenon for asymptotically flat black holes, in which the metric can be determined explicitly in the mass inflation region. In this paper we implement the Ori model for charged AdS black holes. We find that the mass function inflates faster than the flat space case as the inner horizon is approached...

  18. Pure Spinors in AdS and Lie Algebra Cohomology

    Mikhailov, Andrei

    2014-10-01

    We show that the BRST cohomology of the massless sector of the Type IIB superstring on AdS5 × S 5 can be described as the relative cohomology of an infinite-dimensional Lie superalgebra. We explain how the vertex operators of ghost number 1, which correspond to conserved currents, are described in this language. We also give some algebraic description of the ghost number 2 vertices, which appears to be new. We use this algebraic description to clarify the structure of the zero mode sector of the ghost number two states in flat space, and initiate the study of the vertices of the higher ghost number.

  19. ADS National Programmes: Russian Federation

    Studies on accelerator driven systems (ADS), which be used as burners of long lived radioactive waste accrued due to operation of thermal reactors, first of all, minor actinides (MA), are carried out in some Russian research institutes (ITEP, SSC RF - IPPE, VNIIEF, JINR, RSC KI, IYaI RAN, OKB ‘GIDROPRESS’, VNIITF etc.). These researches are mainly connected with studying physical processes existing in ADS and their parameters and with design studies and substantiation of experimental ADS facilities. One of the most important directions of researches is the acquirement of quite precise and reliable nuclear data on MA with reference to conditions existing in ADS. Now a coordinated programme of researches on measurement and estimation of nuclear data for 22 isotopes of U, Pu, Np, Am, Cm, Bk and Cf in neutron energy range from 0.05 eV up to 30 MeV has been prepared. Development of different variants of ADS has put a task of comparison of their efficiency as burners of MA

  20. Introducing ADS 2.0

    Accomazzi, Alberto; Kurtz, M. J.; Henneken, E. A.; Grant, C. S.; Thompson, D.; Luker, J.; Chyla, R.; Murray, S. S.

    2014-01-01

    In the spring of 1993, the Smithsonian/NASA Astrophysics Data System (ADS) first launched its bibliographic search system. It was known then as the ADS Abstract Service, a component of the larger Astrophysics Data System effort which had developed an interoperable data system now seen as a precursor of the Virtual Observatory. As a result of the massive technological and sociological changes in the field of scholarly communication, the ADS is now completing the most ambitious technological upgrade in its twenty-year history. Code-named ADS 2.0, the new system features: an IT platform built on web and digital library standards; a new, extensible, industrial strength search engine; a public API with various access control capabilities; a set of applications supporting search, export, visualization, analysis; a collaborative, open source development model; and enhanced indexing of content which includes the full-text of astronomy and physics publications. The changes in the ADS platform affect all aspects of the system and its operations, including: the process through which data and metadata are harvested, curated and indexed; the interface and paradigm used for searching the database; and the follow-up analysis capabilities available to the users. This poster describes the choices behind the technical overhaul of the system, the technology stack used, and the opportunities which the upgrade is providing us with, namely gains in productivity and enhancements in our system capabilities.

  1. AdCell: Ad Allocation in Cellular Networks

    Alaei, Saeed; Liaghat, Vahid; Pei, Dan; Saha, Barna

    2011-01-01

    With more than four billion usage of cellular phones worldwide, mobile advertising has become an attractive alternative to online advertisements. In this paper, we propose a new targeted advertising policy for Wireless Service Providers (WSPs) via SMS or MMS- namely {\\em AdCell}. In our model, a WSP charges the advertisers for showing their ads. Each advertiser has a valuation for specific types of customers in various times and locations and has a limit on the maximum available budget. Each query is in the form of time and location and is associated with one individual customer. In order to achieve a non-intrusive delivery, only a limited number of ads can be sent to each customer. Recently, new services have been introduced that offer location-based advertising over cellular network that fit in our model (e.g., ShopAlerts by AT&T) . We consider both online and offline version of the AdCell problem and develop approximation algorithms with constant competitive ratio. For the online version, we assume tha...

  2. No Holography for Eternal AdS Black Holes

    Avery, Steven G

    2013-01-01

    It is generally believed that the eternal AdS black hole is dual to two conformal field theories with compact spatial sections that are together in a thermofield double state. We argue that this proposal is incorrect, and by extension so are the "entanglement=geometry" proposal of Van Raamsdonk and "ER=EPR" proposal of Maldacena and Susskind. We show that in the bulk there is an interaction needed between the two halves of the Hilbert space for connectivity across the horizon; however, there is no such interaction between the CFTs. This rules out the possibility of the dual to the CFTs being the eternal AdS black hole. We argue the correct dual "geometries" resemble the exterior of the black hole outside the stretched horizon but cap off before the global horizon. This disallows the possibility of a shared future (and past) wedge where Alice falling from one side can meet Bob falling from the other. We expect that in the UV complete theory the aforementioned caps will be fuzzballs.

  3. AdS Twistors for Higher Spin Theory

    We construct spectra of supersymmetric higher spin theories in D = 4, 5 and 7 from twistors describing massless (super-)particles on AdS spaces. A massless twistor transform is derived in a geometric way from classical kinematics. Relaxing the spin-shell constraints on twistor space gives an infinite tower of massless states of a 'higher spin particle', generalizing previous work of Bandos et al.. This can generically be done in a number of ways, each defining the states of a distinct higher spin theory, and the method provides a systematic way of finding these. We reproduce known results in D = 4, minimal supersymmetric 5- and 7-dimensional models, as well as supersymmetrisations of Vasiliev's Sp-models as special cases. In the latter models a dimensional enhancement takes place, meaning that the theory lives on a space of higher dimension than the original AdS space, and becomes a theory of doubletons. This talk was presented at the XIX-th Max Born Symposium 'Fundamental Interactions and Twistor-Like Methods', September 2004, in Wroclaw, Poland

  4. Bi-Local Fields in AdS${}_5$ Spacetime

    Aouda, Kenichi; Toyoda, Haruki

    2016-01-01

    Recently, the bi-local fields attracts the interest in studying the duality between $O(N)$ vector model and a higher-spin gauge theory in $AdS$ spacetime. In those theories, the bi-local fields are realized as collective one's of the $O(N)$ vector fields, which are the source of higher spin bulk fields. Historically, the bi-local fields are introduced as a candidate of non-local fields by Yukawa. Today, Yukawa's bi-local fields are understood from a viewpoint of relativistic two-particle bound systems, the bi-local systems. We study the relation between the collective bi-local fields out of HS bulk fields and the fields out of bi-local systems embedded in AdS${}_5$ spacetime with warped metric. It is shown that the effective spring tension of the bi-local system depends on the brane, on which the bi-local system is located. In paticular, a tensionless bi-local sytem, being similar to the collective bi-local fields, can be realized on a low-energy visible brane.

  5. Smooth Causal Patches for AdS Black Holes

    Raju, Suvrat

    2016-01-01

    We review the paradox of low energy excitations about an AdS black hole. An appropriately chosen unitary operator in the boundary theory can create a locally strong excitation near the black hole horizon, whose global energy is small as a result of the gravitational redshift. The paradox is that this seems to violate a general rule of statistical mechanics, which states that an operator with energy parametrically smaller than $k T$ cannot create a significant excitation in a thermal system. When we carefully examine the position dependence of the boundary unitary operator that produces the excitation and the bulk observable necessary to detect the anomalously large effect, we find that they do not both fit in a single causal patch. This follows from a remarkable property of position space AdS correlators that we establish explicitly, and resolves the paradox in a generic state of the system, since no combination of observers can both create the excitation and observe its effect. As a special case of our analy...

  6. Conserved charges in timelike warped AdS3 spaces

    Donnay, L.; Fernández-Melgarejo, J. J.; Giribet, G.; Goya, A.; Lavia, E.

    2015-06-01

    We consider the timelike version of warped anti-de Sitter space (WAdS), which corresponds to the three-dimensional section of the Gödel solution of four-dimensional cosmological Einstein equations. This geometry presents closed timelike curves (CTCs), which are inherited from its four-dimensional embedding. In three dimensions, this type of solution can be supported without matter provided the graviton acquires mass. Here, among the different ways to consistently give mass to the graviton in three dimensions, we consider the parity-even model known as new massive gravity (NMG). In the bulk of timelike WAdS3 space, we introduce defects that, from the three-dimensional point of view, represent spinning massive particlelike objects. For this type of source, we investigate the definition of quasilocal gravitational energy as seen from infinity, far beyond the region where the CTCs appear. We also consider the covariant formalism applied to NMG to compute the mass and the angular momentum of spinning particlelike defects and compare the result with the one obtained by means of the quasilocal stress tensor. We apply these methods to special limits in which the WAdS3 solutions coincide with locally AdS3 and locally AdS2×R spaces. Finally, we make some comments about the asymptotic symmetry algebra of asymptotically WAdS3 spaces in NMG.

  7. The CFT dual of AdS gravity with torsion

    We consider the Mielke-Baekler model of three-dimensional AdS gravity with torsion, which has gravitational and translational Chern-Simons terms in addition to the usual Einstein-Hilbert action with cosmological constant. It is shown that the topological nature of the model leads to a finite Fefferman-Graham expansion. We derive the holographic stress tensor and the associated Ward identities and show that, due to the asymmetry of the left- and right-moving central charges, a Lorentz anomaly appears in the dual conformal field theory. Both the consistent and the covariant Weyl and Lorentz anomaly are determined, and the Wess-Zumino consistency conditions for the former are verified. Moreover we consider the most general solution with flat boundary geometry, which describes left- and right-moving gravitational waves on AdS3 with torsion, and show that in this case the holographic energy-momentum tensor is given by the wave profiles. The anomalous transformation laws of the wave profiles under diffeomorphisms preserving the asymptotic form of the bulk solution yield the central charges of the dual CFT and confirm the results that appeared earlier on in the literature. Finally we comment on some points concerning the microstate counting for the Riemann-Cartan black hole

  8. Quantum cat map dynamics on AdS$_2$

    Axenides, Minos; Nicolis, Stam

    2016-01-01

    We present a toy model for the chaotic unitary scattering of single particle wave packets on the radial AdS$_2$ geometry of extremal BH horizons. Based on our recent work for the discretization of the AdS$_2$ space-time, which describes a finite and random geometry, by modular arithmetic, we investigate the validity of the eigenstate thermalization hypothesis (ETH), as well as that of the fast scrambling time bound conjecture (STB), for an observer with time evolution operator the quantum Arnol'd cat map (QACM). We find that the QACM, while possessing a linear spectrum, has eigenstates, which can be expressed in closed form, are found to be random and to satisfy the assumptions of the ETH.The implications are that the dynamics is described by a chaotic, unitary, single particle S-matrix, which completely delocalizes and randomizes initial gaussian wave packets . Applying results obtained by Dyson and Falk for the periods of the Arnol'd Cat Map(ACM),which are related to its mixing time, we also find that the t...

  9. Influence of coagulation factor x on in vitro and in vivo gene delivery by adenovirus (Ad) 5, Ad35, and chimeric Ad5/Ad35 vectors.

    Greig, Jenny A; Buckley, Suzanne Mk; Waddington, Simon N; Parker, Alan L; Bhella, David; Pink, Rebecca; Rahim, Ahad A; Morita, Takashi; Nicklin, Stuart A; McVey, John H; Baker, Andrew H

    2009-10-01

    The binding of coagulation factor X (FX) to the hexon of adenovirus (Ad) 5 is pivotal for hepatocyte transduction. However, vectors based on Ad35, a subspecies B Ad, are in development for cancer gene therapy, as Ad35 utilizes CD46 (which is upregulated in many cancers) for transduction. We investigated whether interaction of Ad35 with FX influenced vector tropism using Ad5, Ad35, and Ad5/Ad35 chimeras: Ad5/fiber(f)35, Ad5/penton(p)35/f35, and Ad35/f5. Surface plasmon resonance (SPR) revealed that Ad35 and Ad35/f5 bound FX with approximately tenfold lower affinities than Ad5 hexon-containing viruses, and electron cryomicroscopy (cryo-EM) demonstrated a direct Ad35 hexon:FX interaction. The presence of physiological levels of FX significantly inhibited transduction of vectors containing Ad35 fibers (Ad5/f35, Ad5/p35/f35, and Ad35) in CD46-positive cells. Vectors were intravenously administered to CD46 transgenic mice in the presence and absence of FX-binding protein (X-bp), resulting in reduced liver accumulation for all vectors. Moreover, Ad5/f35 and Ad5/p35/f35 efficiently accumulated in the lung, whereas Ad5 demonstrated poor lung targeting. Additionally, X-bp significantly reduced lung genome accumulation for Ad5/f35 and Ad5/p35/f35, whereas Ad35 was significantly enhanced. In summary, vectors based on the full Ad35 serotype will be useful vectors for selective gene transfer via CD46 due to a weaker FX interaction compared to Ad5. PMID:19603000

  10. Online Ad Slotting With Cancellations

    Constantin, Florin; Muthukrishnan, S; Pal, Martin

    2008-01-01

    Many advertisers buy advertisements (ads) on the Internet or on traditional media and seek simple, online mechanisms to reserve ad slots in advance. Media publishers represent a vast and varying inventory, and they too seek automatic, online mechanisms for pricing and allocating such reservations. In this paper, we present and study a simple model for auctioning such ad slots in advance. Bidders arrive sequentially and report which slots they are interested in. The seller must decide immediately whether or not to grant a reservation. Our model allows a seller to accept reservations, but possibly cancel the allocations later and pay the bidder a cancellation compensation (bump payment). Our main result is an online mechanism to derive prices and bump payments that is efficient to implement. This mechanism has many desirable properties. It is individually rational; winners have an incentive to be honest and bidding one's true value dominates any lower bid. Our mechanism's efficiency is within a constant fractio...

  11. Neutronic design of an ADS

    We present a LEU-ADS design based on an existing Argentine experimental facility, the RA-8 pool type zero power reactor. The versatility of this reactor allows measurement of different core configurations using different fuel enrichment, burnable poison rods, water perturbations and different control rods types in critical or subcritical configurations with an external source. To assess the feasibility of the LEU-ADS, multiplication factors, kinetic parameters, spectra, and time flux evolution were computed. Two external sources were considered: an isotopic 252Cf source, and a D-D pulsed neutron source. Parameters for different core configurations were calculated, and the feasibility of using continuous and pulsed neutron sources was verified.

  12. Belarus activity in ADS field

    Conclusions: • The YALINA facility is a unique installation which was designed as a zero power model of real ADS. • It is intended to study neutronics and kinetics of the sub-critical reactors driven by external neutron sources. • The successful operation of this facility is a scientific contribution from the Republic of Belarus, as well as the international team from EC and USA. • The experimental data are used to benchmark and validate methods and computer codes for designing and licensing ADS

  13. Holographic properties in three-dimensional AdS soliton using $AdS_3/CFT_2$

    Peng, Yan

    2016-01-01

    We study the holographic description of a superconductor by the $AdS_{3}/CFT_{2}$ correspondence. The system is constructed with a Maxwell field and a charged scalar field coupled in the (2+1)-dimensional AdS soliton background. With analytical methods, we obtain the exact expression for the critical chemical potential as $\\mu_{c} = 1 + \\sqrt{1+m^2}$, which has also been generalized to higher dimensions as $\\mu_c \\thickapprox a + \\sqrt{m^2-m_{BF}^2}$ in this work. Around the phase transition points, we find a correspondence between the value of the scalar field at the tip and the scalar operator at infinity. We also arrive at the classical second order phase transition threshold exponent $\\beta=\\frac{1}{2}$ as the same as the mean field theory near the critical chemical potential. As the condensation becomes heavier, we show surprisingly that superconducting phases exist only in a certain range of the chemical potential, which is very different from higher-dimensional cases. And for the small enough negative ...

  14. The AdMit Package

    D. David (David); L.F. Hoogerheide (Lennart); H.K. van Dijk (Herman)

    2008-01-01

    textabstractThis short note presents the R package AdMit which provides flexible functions to approximate a certain target distribution and it provides an efficient sample of random draws from it, given only a kernel of the target density function. The estimation procedure is fully automatic and thu

  15. An Investigation of AdS2 Backreaction and Holography

    Engelsöy, Julius; Verlinde, Herman

    2016-01-01

    We investigate a dilaton gravity model in AdS2 proposed by Almheiri and Polchinski and develop an 1D effective description in terms of a dynamical boundary time with a Schwarzian derivative action. We show that the effective model is equivalent to a 1D version of Liouville theory, and investigate its dynamics and symmetries via a standard canonical framework. We include the coupling to arbitrary conformal matter and analyze the effective action in the presence of possible sources. We compute commutators of local operators at large time separation, and match the result with the time shift due to a gravitational shockwave interaction. We study a black hole evaporation process and comment on the role of entropy in this model.

  16. On jordanian deformations of AdS_5 and supergravity

    Hoare, Ben

    2016-01-01

    We consider various homogeneous Yang-Baxter deformations of the AdS_5 x S^5 superstring that can be obtained from the eta-deformed superstring and related models by singular boosts. The jordanian deformations we obtain in this way behave similarly to the eta-deformed model with regard to supergravity: T dualizing the classical sigma model it is possible to find corresponding solutions of supergravity, which, however, have dilatons that prevent T dualizing back. Hence the backgrounds of these jordanian deformations are not solutions of supergravity. Still, they do satisfy a set of recently found modified supergravity equations which should imply that the corresponding sigma models are scale invariant. The abelian models that we obtain by singular boosts do directly correspond to solutions of supergravity. In addition to our main results we consider contraction limits of our main example, which also do not correspond to supergravity solutions.

  17. Colliding waves on a string in AdS$_3$

    Vegh, David

    2015-01-01

    This paper is concerned with the classical motion of a string in global AdS$_3$. The initially static string stretches between two antipodal points on the boundary circle. Both endpoints are perturbed which creates cusps at a steady rate. The cusps propagate towards the interior where they collide. The behavior of the string depends on the strength of forcing. Three qualitatively different phases can be distinguished: transparent, gray, and black. The transparent region is analogous to a standing wave. In the black phase, there is a horizon on the worldsheet and cusps never reach the other endpoint. The string keeps folding and its length grows linearly over time. In the gray phase, the string still grows linearly. However, cusps do cross to the other side. The transparent and gray regions are separated by a transition point where a logarithmic accumulation of cusps is numerically observed. A simple model reproduces the qualitative behavior of the string in the three phases.

  18. Thermodynamics of charged Lovelock: AdS black holes

    Prasobh, C.B.; Suresh, Jishnu; Kuriakose, V.C. [Cochin University of Science and Technology, Department of Physics, Cochin (India)

    2016-04-15

    We investigate the thermodynamic behavior of maximally symmetric charged, asymptotically AdS black hole solutions of Lovelock gravity. We explore the thermodynamic stability of such solutions by the ordinary method of calculating the specific heat of the black holes and investigating its divergences which signal second-order phase transitions between black hole states. We then utilize the methods of thermodynamic geometry of black hole spacetimes in order to explain the origin of these points of divergence. We calculate the curvature scalar corresponding to a Legendre-invariant thermodynamic metric of these spacetimes and find that the divergences in the black hole specific heat correspond to singularities in the thermodynamic phase space. We also calculate the area spectrum for large black holes in the model by applying the Bohr-Sommerfeld quantization to the adiabatic invariant calculated for the spacetime. (orig.)

  19. The Analytic Bootstrap and AdS Superhorizon Locality

    Fitzpatrick, A Liam; Poland, David; Simmons-Duffin, David

    2012-01-01

    We take an analytic approach to the CFT bootstrap, studying the 4-pt correlators of d > 2 dimensional CFTs in an Eikonal-type limit, where the conformal cross ratios satisfy |u| 2\\Delta_\\phi\\ + 2n for each integer n as l -> infinity. We show how the rate of approach is controlled by the twist and OPE coefficient of the leading twist operator in the \\phi\\ x \\phi\\ OPE, and we discuss SCFTs and the 3d Ising Model as examples. Additionally, we show that the OPE coefficients of other large spin operators appearing in the OPE are bounded as l -> infinity. We interpret these results as a statement about superhorizon locality in AdS for general CFTs.

  20. Thermodynamics of charged Lovelock: AdS black holes

    We investigate the thermodynamic behavior of maximally symmetric charged, asymptotically AdS black hole solutions of Lovelock gravity. We explore the thermodynamic stability of such solutions by the ordinary method of calculating the specific heat of the black holes and investigating its divergences which signal second-order phase transitions between black hole states. We then utilize the methods of thermodynamic geometry of black hole spacetimes in order to explain the origin of these points of divergence. We calculate the curvature scalar corresponding to a Legendre-invariant thermodynamic metric of these spacetimes and find that the divergences in the black hole specific heat correspond to singularities in the thermodynamic phase space. We also calculate the area spectrum for large black holes in the model by applying the Bohr-Sommerfeld quantization to the adiabatic invariant calculated for the spacetime. (orig.)

  1. An investigation of AdS2 backreaction and holography

    Engelsöy, Julius; Mertens, Thomas G.; Verlinde, Herman

    2016-07-01

    We investigate a dilaton gravity model in AdS2 proposed by Almheiri and Polchinski [1] and develop a 1d effective description in terms of a dynamical boundary time with a Schwarzian derivative action. We show that the effective model is equivalent to a 1d version of Liouville theory, and investigate its dynamics and symmetries via a standard canonical framework. We include the coupling to arbitrary conformal matter and analyze the effective action in the presence of possible sources. We compute commutators of local operators at large time separation, and match the result with the time shift due to a gravitational shockwave interaction. We study a black hole evaporation process and comment on the role of entropy in this model.

  2. On Information Loss in AdS$_3$/CFT$_2$

    Fitzpatrick, A Liam; Li, Daliang; Wang, Junpu

    2016-01-01

    We discuss information loss from black hole physics in AdS$_3$, focusing on two sharp signatures infecting CFT$_2$ correlators at large central charge $c$: 'forbidden singularities' arising from Euclidean-time periodicity due to the effective Hawking temperature, and late-time exponential decay in the Lorentzian region. We study an infinite class of examples where forbidden singularities can be resolved by non-perturbative effects at finite $c$, and we show that the resolution has certain universal features that also apply in the general case. Analytically continuing to the Lorentzian regime, we find that the non-perturbative effects that resolve forbidden singularities qualitatively change the behavior of correlators at times $t \\sim S_{BH}$, the black hole entropy. This may resolve the exponential decay of correlators at late times in black hole backgrounds. By Borel resumming the $1/c$ expansion of exact examples, we explicitly identify 'information-restoring' effects from heavy states that should correspo...

  3. Correlation Functions of Winding Strings in AdS_3

    Minces, Pablo

    2008-01-01

    We review certain results for amplitudes of spectral flowed operators in string theory on AdS_3. We present the modified Knizhnik-Zamolodchikov and null vector equations to be satisfied by correlators including w=1 operators. We then discuss the three point function of two w=1 and one w=0 operators in the x-basis, and perform a consistency check on the definition of the w=1 operator. We finally exhibit the steps in the calculation of the winding conserving four point functions for operators in arbitrary spectral flowed sectors, both in the m- and x-basis, under the only assumption that at least one of the operators is in the spectral flowed image of the highest weight discrete representation.

  4. International Programmes on ADS: The Asian ADS Network

    As the management of radioactive wastes is a common issue for all the countries utilizing nuclear energy and also for those intending to start it, international multilateral collaboration must be of great importance for effective research and development of transmutation technology for long lived nuclides. Collaboration in Asian region, however, had been less active in comparison to European countries, though nuclear power generation would increase significantly in Asia. Considering this context, the former Japan Atomic Energy Research Institute (JAERI) convened the ‘International Symposium on Accelerator driven Transmutation Systems and Asia ADS Network Initiative’ on March 24 and 25, 2003 at Tokyo, Japan in cooperation with Kyoto University, Osaka University, High Energy Accelerator Research Organization and Tokyo Institute of Technology. Through the discussion in the symposium, common understanding was developed in Japanese, Korean and Chinese scientists concerning the importance of establishing an international network among Asian countries to facilitate information exchange for R&D of ADS. Based on this understanding, five workshops were held so far. The workshop covers the national R&D programmes on ADS including subcritical reactor physics, cross-section measurements, high energy particle physics, accelerator technology, material technology and MA fuel technology. From the fifth workshop, information exchange for R&D on innovative fast reactors for nuclear transmutation was also included

  5. Islands of stability and recurrence times in AdS

    Green, Stephen R; Lehner, Luis; Liebling, Steven L

    2015-01-01

    We study the stability of anti-de Sitter (AdS) spacetime to spherically symmetric perturbations of a real scalar field in general relativity. Further, we work within the context of the "two time framework" (TTF) approximation, which describes the leading nonlinear effects for small amplitude perturbations, and is therefore suitable for studying the weakly turbulent instability of AdS---including both collapsing and non-collapsing solutions. We have previously identified a class of quasi-periodic (QP) solutions to the TTF equations, and in this work we analyze their stability. We show that there exist several families of QP solutions that are stable to linear order, and we argue that these solutions represent islands of stability in TTF. We extract the eigenmodes of small oscillations about QP solutions, and we use them to predict approximate recurrence times for generic non-collapsing initial data in the full (non-TTF) system. Alternatively, when sufficient energy is driven to high-frequency modes, as occurs ...

  6. Islands of stability and recurrence times in AdS

    Green, Stephen R.; Maillard, Antoine; Lehner, Luis; Liebling, Steven L.

    2015-10-01

    We study the stability of anti-de Sitter (AdS) spacetime to spherically symmetric perturbations of a real scalar field in general relativity. Further, we work within the context of the "two time framework" (TTF) approximation, which describes the leading nonlinear effects for small amplitude perturbations, and is therefore suitable for studying the weakly turbulent instability of AdS—including both collapsing and noncollapsing solutions. We have previously identified a class of quasiperiodic (QP) solutions to the TTF equations, and in this paper we analyze their stability. We show that there exist several families of QP solutions that are stable to linear order, and we argue that these solutions represent islands of stability in TTF. We extract the eigenmodes of small oscillations about QP solutions, and we use them to predict approximate recurrence times for generic noncollapsing initial data in the full (non-TTF) system. Alternatively, when sufficient energy is driven to high-frequency modes, as occurs for initial data far from a QP solution, the TTF description breaks down as an approximation to the full system. Depending on the higher order dynamics of the full system, this often signals an imminent collapse to a black hole.

  7. Scattering States in AdS/CFT

    Fitzpatrick, A.Liam; /Boston U.; Kaplan, Jared; /SLAC

    2012-02-14

    We show that suitably regulated multi-trace primary states in large N CFTs behave like 'in' and 'out' scattering states in the flat-space limit of AdS. Their transition matrix elements approach the exact scattering amplitudes for the bulk theory, providing a natural CFT definition of the flat space S-Matrix. We study corrections resulting from the AdS curvature and particle propagation far from the center of AdS, and show that AdS simply provides an IR regulator that disappears in the flat space limit.

  8. Facilities Management and Added Value

    Jensen, Per Anker

    2010-01-01

    is based on literature reviews of the most influential journals within the academic fields of FM, Corporate Real Estate Management and Business to Business Marketing and discussions between participants of the research group working on a further exploration and testing of the FM Value Map. Conclusions......Aim: This paper aims to present different models of the concept of the added value of Facilities Management (FM), including the FM Value Map, which forms the basis of research group in EuroFM, and to present some of the results of this research collaboration. Approach and methodology: The paper...... on the aimed output) and the internal resource based view (with a focus on the input from FM and RE). Good relationship management and building on trust shows to be equally important as delivering the agreed services. In order to measure the multi-dimensional components of adding value both qualitative...

  9. MUSICAL ARRANGEMENT OF MEDIA ADS

    Chernyshov Alexander V.

    2015-01-01

    The music-compositional principles of commercial and political advertising and also the self-promotion of electronic media (radio, television, Internet) are considered in this mediatext: from the elementary beeps, symbolic functions, emblems/logos and musical brands to the sound engineering technology to underscore the product's name and the complex synthesis between music and intra movements and color-light design of frames. Simultaneously examines, how the musical arrangement of ethereal ad...

  10. Functional foods for added value

    Mark-Herbert, Cecilia

    2002-01-01

    In this study innovation involves the development of a new product category; i.e. new products, new processes and new business. The development process is conveyed in narratives where a radically new product group, functional foods, is developed. These high-tech food products are associated with added value for the food business as well as for individuals and society at large. In the past decades Swedish food companies have faced an increasing competition. With increased competitive pressures...

  11. International Programmes on ADS: ISTC

    The International Science and Technology Center (ISTC) is an intergovernmental organization, created to serve the goal of improving global safety and security. The European Union, Japan, the Russian Federation and the United States of America, on the basis of a multinational agreement, established ISTC in 1992. The ISTC focused its efforts on funding research projects related to key safety and security technologies including advanced nuclear technology. Since the first ISTC funded project in 1994, Accelerator Driven Systems, Transmutation research and a holistic approach to the nuclear fuel cycle were the areas where ISTC made a real impact on international development in these fields. Given the international dimension of the problem, the research communities of the ISTC member states quickly realized that ISTC projects offered a very flexible and fruitful cooperation platform to address many difficult issues of the nuclear fuel cycle. Highly competent expert communities of ISTC member states benefited from a well defined and transparent mode of operation of ISTC and objective oriented project funding strategy. The ISTC projects related to transmutation of radioactive waste and ADS can be classified in the following thematic areas: - ADS concepts; - Accelerator development; - Spallation target studies; - Nuclear data and spallation process studies; - Minor actinides studies related to ADS; - Partitioning and extraction

  12. Effects of Flavonoid-rich Plant Extracts on In vitro Ruminal Methanogenesis, Microbial Populations and Fermentation Characteristics.

    Kim, Eun T; Guan, Le Luo; Lee, Shin J; Lee, Sang M; Lee, Sang S; Lee, Il D; Lee, Su K; Lee, Sung S

    2015-04-01

    The objective of this study was to evaluate the in vitro effects of flavonoid-rich plant extracts (PE) on ruminal fermentation characteristics and methane emission by studying their effectiveness for methanogenesis in the rumen. A fistulated Holstein cow was used as a donor of rumen fluid. The PE (Punica granatum, Betula schmidtii, Ginkgo biloba, Camellia japonica, and Cudrania tricuspidata) known to have high concentrations of flavonoid were added to an in vitro fermentation incubated with rumen fluid. Total gas production and microbial growth with all PE was higher than that of the control at 24 h incubation, while the methane emission was significantly lower (pPunica, Betula, Ginkgo, Camellia, and Cudrania treatments, respectively. Ciliate populations were reduced by more than 60% in flavonoid-rich PE treatments. The Fibrobacter succinogenes diversity in all added flavonoid-rich PE was shown to increase, while the Ruminoccocus albus and R. flavefaciens populations in all PE decreased as compared with the control. In particular, the F. succinogenes community with the addition of Birch extract increased to a greater extent than that of others. In conclusion, the results of this study showed that flavonoid-rich PE decreased ruminal methane emission without adversely affecting ruminal fermentation characteristics in vitro in 24 h incubation time, suggesting that the flavonoid-rich PE have potential possibility as bio-active regulator for ruminants. PMID:25656200

  13. AdS/Ricci-flat correspondence

    We present a comprehensive analysis of the AdS/Ricci-flat correspondence, a map between a class of asymptotically locally AdS spacetimes and a class of Ricci-flat spacetimes. We provide a detailed derivation of the map, discuss a number of extensions and apply it to a number of important examples, such as AdS on a torus, AdS black branes and fluids/gravity metrics. In particular, the correspondence links the hydrodynamic regime of asymptotically flat black p-branes or the Rindler fluid with that of AdS. It implies that this class of Ricci-flat spacetimes inherits from AdS a generalized conformal symmetry and has a holographic structure. We initiate the discussion of holography by analyzing how the map acts on boundary conditions and holographic 2-point functions

  14. AdS/Ricci-flat correspondence

    Caldarelli, M M; Goutéraux, B; Skenderis, K

    2014-01-01

    We present a comprehensive analysis of the AdS/Ricci-flat correspondence, a map between a class of asymptotically locally AdS spacetimes and a class of Ricci-flat spacetimes. We provide a detailed derivation of the map, discuss a number of extensions and apply the map to a number of important examples, such as AdS on a torus, AdS black branes and fluids/gravity metrics. In particular, the map links the hydrodynamic regime of asymptotically flat black $p$-branes or the Rindler fluid with that of AdS. The map implies that this class of Ricci-flat spacetimes inherits from AdS a generalized conformal symmetry and has a holographic structure. We initiate the discussion of holography by analyzing how the map acts on boundary conditions and holographic 2-point functions.

  15. Magnetic Mass in 4D AdS Gravity

    Araneda, Rene; Miskovic, Olivera; Olea, Rodrigo

    2016-01-01

    We provide a fully-covariant expression for the diffeomorphic charge in 4D anti-de Sitter gravity, when the Gauss-Bonnet and Pontryagin terms are added to the action. The couplings of these topological invariants are such that the Weyl tensor and its dual appear in the on-shell variation of the action, and such that the action is stationary for asymptotic (anti) self-dual solutions in the Weyl tensor. In analogy with Euclidean electromagnetism, whenever the self-duality condition is global, both the action and the total charge are identically vanishing. Therefore, for such configurations the magnetic mass equals the Ashtekhar-Magnon-Das definition.

  16. Magnetic mass in 4D AdS gravity

    Araneda, René; Aros, Rodrigo; Miskovic, Olivera; Olea, Rodrigo

    2016-04-01

    We provide a fully covariant expression for the diffeomorphic charge in four-dimensional anti-de Sitter gravity, when the Gauss-Bonnet and Pontryagin terms are added to the action. The couplings of these topological invariants are such that the Weyl tensor and its dual appear in the on-shell variation of the action and such that the action is stationary for asymptotic (anti-)self-dual solutions in the Weyl tensor. In analogy with Euclidean electromagnetism, whenever the self-duality condition is global, both the action and the total charge are identically vanishing. Therefore, for such configurations, the magnetic mass equals the Ashtekhar-Magnon-Das definition.

  17. Canonical energy and hairy AdS black holes

    Hyun, Seungjoon; Park, Sang-A.; Yi, Sang-Heon

    2016-08-01

    We propose the modified version of the canonical energy which was introduced originally by Hollands and Wald. Our construction depends only on the Euler-Lagrange expression of the system and thus is independent of the ambiguity in the Lagrangian. After some comments on our construction, we briefly mention on the relevance of our construction to the boundary information metric in the context of the AdS/CFT correspondence. We also study the stability of three-dimensional hairy extremal black holes by using our construction.

  18. Stability of Charged Global AdS$_4$ Spacetimes

    Arias, Raúl; Serantes, Alexandre

    2016-01-01

    We study linear and nonlinear stability of asymptotically AdS$_4$ solutions in Einstein-Maxwell-scalar theory. After summarizing the set of static solutions we first examine thermodynamical stability in the grand canonical ensemble and the phase transitions that occur among them. In the second part of the paper we focus on nonlinear stability in the microcanonical ensemble by evolving radial perturbations numerically. We find hints of an instability corner for vanishingly small perturbations of the same kind as the ones present in the uncharged case. Collapses are avoided, instead, if the charge and mass of the perturbations come to close the line of solitons. Finally we examine the soliton solutions. The linear spectrum of normal modes is not resonant and instability turns on at extrema of the mass curve. Linear stability extends to nonlinear stability up to some threshold for the amplitude of the perturbation. Beyond that, the soliton is destroyed and collapses to a hairy black hole. The relative width of t...

  19. Spectrum and statistical entropy of AdS black holes

    Popular approaches to quantum gravity describe black hole microstates differently and apply different statistics to count them. Since the relationship between the approaches is not clear, this obscures the role of statistics in calculating the black hole entropy. We address this issue by discussing the entropy of eternal AdS black holes in dimension four and above within the context of a midisuperspace model. We determine the black hole eigenstates and find that they describe the quantization in half integer units of a certain function of the Arnowitt-Deser-Misner (ADM) mass and the cosmological constant. In the limit of a vanishing cosmological constant (the Schwarzschild limit) the quantized function becomes the horizon area and in the limit of a large cosmological constant it approaches the ADM mass of the black holes. We show that in the Schwarzschild limit the area quatization leads to the Bekenstein-Hawking entropy if Boltzmann statistics are employed. In the limit of a large cosmological constant the Bekenstein-Hawking entropy can be recovered only via Bose statistics. The two limits are separated by a first order phase transition, which seems to suggest a shift from ''particlelike'' degrees of freedom at large cosmological constant to geometric degrees of freedom as the cosmological constant approaches zero.

  20. International Programmes on ADS: IAEA

    The IAEA recognizes that there are four major challenges facing the long term development of nuclear energy as a part of the world’s energy mix: improvement of the economic competitiveness, meeting increasingly stringent safety requirements, adhering to the criteria of sustainable development, and public acceptance. Meeting the sustainability criteria is the driving force behind IAEA’s activity in the area of innovative transmutation reactor technology development and, in particular, Accelerator Driven Systems. The framework for all the IAEA activities in the ADS area is the Technical Working Group on Fast Reactors (TWG-FR). In response to strong common R&D needs in the Member States, the TWG-FR acts as a catalyst for international information exchange and collaborative R&D. It provides a forum for exchange of non-commercial scientific and technical information, and a forum for international cooperation on generic research and development programmes on advances in fast reactors and fast spectrum accelerator driven systems. Its present members are the following 15 IAEA Member States: Belarus, Brazil, China, France, Germany, India, Italy, Japan, Kazakhstan, Republic of Korea, Russian Federation, Sweden, Switzerland, United Kingdom, and United States of America, as well as 3 international organizations: ISTC, OECD-NEA, and EU (EC). As observers, the TWG-FR has welcomed Argentina and Belgium. Last but not least, the IAEA is providing the ADS Research and Development Database. It contains information about ADS related R&D programmes, existing and planned experimental facilities as well as programmes, methods and data development efforts, design studies, and so forth

  1. ADS activities in the Netherlands

    The problem of long-lived nuclear waste was under consideration in the Netherlands during a number of years. Within this framework different reactor concepts have been considered. One of the most promising concepts appears to be the Accelerator Driven System (ADS) or Fast Energy Amplifier (FEA), as it has been proposed by C. Rubbia of CERN. To unite the effort on accelerator driven reactor concepts in the Netherlands, KEMA, NIKHEF, ECN, KVI, and IRI have joined their forces in a co-operative program since 1996. Cupertino covers the technical fields of nuclear data, reactor physics, and innovative fuels. (author)

  2. Entanglement Entropy of AdS Black Holes

    Maurizio Melis

    2010-11-01

    Full Text Available We review recent progress in understanding the entanglement entropy of gravitational configurations for anti-de Sitter gravity in two and three spacetime dimensions using the AdS/CFT correspondence. We derive simple expressions for the entanglement entropy of two- and three-dimensional black holes. In both cases, the leading term of the entanglement entropy in the large black hole mass expansion reproduces exactly the Bekenstein-Hawking entropy, whereas the subleading term behaves logarithmically. In particular, for the BTZ black hole the leading term of the entanglement entropy can be obtained from the large temperature expansion of the partition function of a broad class of 2D CFTs on the torus.

  3. Minimal area submanifolds in AdS x compact

    Graham, C Robin

    2014-01-01

    We describe the asymptotic behavior of minimal area submanifolds in product spacetimes of an asymptotically hyperbolic space times a compact internal manifold. In particular, we find that unlike the case of a minimal area submanifold just in an asymptotically hyperbolic space, the internal part of the boundary submanifold is constrained to be itself a minimal area submanifold. For applications to holography, this tells us what are the allowed "flavor branes" that can be added to a holographic field theory. We also give a compact geometric expression for the spectrum of operator dimensions associated with the slipping modes of the submanifold in the internal space. We illustrate our results with several examples, including some that haven't appeared in the literature before.

  4. Characterizing endogenous and oxidative low molecular weight flavor/aroma compounds in fresh squeezed/blended pomegranate juice.

    Little published information exists regarding flavor and aroma compounds in pomegranate (Punica granatum) juices. Although, arils have fruity and sweet characteristics, we found no publications describing volatile and semi-volatile compounds responsible for their typical flavor. Only two reports w...

  5. Influence of nitrogen rate and drip application method on pomegranate fruit yield and quality

    Currently, 98% of domestic commercial pomegranate fruit (Punica granatum L.) are produced in California on over 13,000 ha. Developing more efficient methods of water and fertilizer application are important in reducing production costs. In 2012, a pomegranate orchard established in 2010 with a den...

  6. Priapism, pomegranate juice, and sildenafil: Is there a connection?

    Subramanian Senthilkumaran; Namasivayam Balamurugan; Ponuswamy Suresh; Ponniah Thirumalaikolundusubramanian

    2012-01-01

    We report the development of low flow priapism in three patients related to simultaneous consumption of sildenafil with pomegranate (Punica granatum) (POM) juice. There were no other concurrent diseases, intake of drugs, and chemicals or other risk factors in these patients. We want to create awareness among patients and practitioners for recognition and timely intervention. Probable mechanisms are highlighted.

  7. Pomegranate flower extract diminishes cardiac fibrosis in Zucker diabetic fatty rats: modulation of cardiac endothelin-1 and nuclear factor-kappaB pathways.

    Huang, Tom H W; Yang, Qinglin; Harada, Masaki; Li, George Q; Yamahara, Johji; Roufogalis, Basil D; Li, Yuhao

    2005-12-01

    The diabetic heart shows increased fibrosis, which impairs cardiac function. Endothelin (ET)-1 and nuclear factor-kappaB (NF-kappaB) interactively regulate fibroblast growth. We have recently demonstrated that Punica granatum flower (PGF), a Unani anti-diabetic medicine, is a dual activator of peroxisome proliferator-activated receptor (PPAR)-alpha and -gamma, and improves hyperglycemia, hyperlipidemia, and fatty heart in Zucker diabetic fatty (ZDF) rat, a genetic animal model of type 2 diabetes and obesity. Here, we demonstrated that six-week treatment with PGF extract (500 mg/kg, p.o.) in Zucker diabetic fatty rats reduced the ratios of van Gieson-stained interstitial collagen deposit area to total left ventricular area and perivascular collagen deposit areas to coronary artery media area in the heart. This was accompanied by suppression of overexpressed cardiac fibronectin and collagen I and III mRNAs. Punica granatum flower extract reduced the up-regulated cardiac mRNA expression of ET-1, ETA, inhibitor-kappaBbeta and c-jun, and normalized the down-regulated mRNA expression of inhibitor-kappaBalpha in Zucker diabetic fatty rats. In vitro, Punica granatum flower extract and its components oleanolic acid, ursolic acid, and gallic acid inhibited lipopolysaccharide-induced NF-kappaB activation in macrophages. Our findings indicate that Punica granatum flower extract diminishes cardiac fibrosis in Zucker diabetic fatty rats, at least in part, by modulating cardiac ET-1 and NF-kappaB signaling. PMID:16306813

  8. Influence of white plastic and water replacement rates on pomegranate orchard phenology, fruit yield and quality

    Currently, 98% of domestic commercial pomegranate fruit (Punica granatum L.) are produced in California on over 13,000 ha. In 2013, a pomegranate orchard, established in 2010 with a density of 558 trees/ha, was irrigated at water replacement rates of 35, 50 and 100% based on rainfall, tree water r...

  9. Stigmaeus ceylani, a new species of the genus Stigmaeus Koch (Acari: Stigmaeidae) from Turkey

    Uluçay, İsmail

    2015-01-01

    In this study a new species of Stigmaeus Koch (Acari: Stigmaeidae), Stigmaeus ceylani sp. nov., is described and illustrated. Specimens have been collected from the soil and litter under Punica granatum, 2014, İskenderun, Hatay, Turkey. Besides, the male, female, deutonymph, protonymph and larva of the species are illustrated in this article.  

  10. Emerging fruit crops

    Hundreds of fruit species with commercial potential are currently in a status of low economic importance. Some, such as quince (Cydonia oblonga L.), pomegranate (Punica granatum L.), and figs (Ficus carica L.) , have been cultivated for thousands of years. Others have only been locally collected an...

  11. THE POMEGRANATE: A NEW LOOK AT THE FRUIT OF PARADISE

    The pomegranate, Punica granatum, is one of 2 members of the Punicaceae family. The plant was first domesticated approximately 10,000 years ago in Iran, where it is native, and Turkey. The fruit may have been the “apple” that Eve was deceived by the snake into partaking. Cultivation of the fruit q...

  12. Antimicrobial and Free Radical Scavenging Activities of Five Palestinian Medicinal Plants

    Qabaha, Khaled Ibraheem

    2013-01-01

    Extracts from five indigenous Palestinian medicinal plants including Rosmarinus officinalis, Pisidium guajava, Punica granatum peel, grape seeds and Teucrium polium were investigated for antimicrobial and free radical scavenging activities against eight microorganisms, using well diffusion method. The microorganisms included six bacterial isolates (i.e. Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginos, Klebsiella pneumonia, Bacillus subtilis and Micrococcus luteus) and two funga...

  13. Priapism, pomegranate juice, and sildenafil: Is there a connection?

    Subramanian Senthilkumaran

    2012-01-01

    Full Text Available We report the development of low flow priapism in three patients related to simultaneous consumption of sildenafil with pomegranate (Punica granatum (POM juice. There were no other concurrent diseases, intake of drugs, and chemicals or other risk factors in these patients. We want to create awareness among patients and practitioners for recognition and timely intervention. Probable mechanisms are highlighted.

  14. Antibacterial activity of plant extracts and phytochemicals on antibiotic-resistant bacteria Atividade de extratos vegetais e fitofármacos sobre bactérias resistentes a antibióticos

    Gislene G. F. Nascimento; Juliana Locatelli; Paulo C. Freitas; Giuliana L. Silva

    2000-01-01

    The antimicrobial activity of plant extracts and phytochemicals was evaluated with antibiotic susceptible and resistant microorganisms. In addition, the possible synergistic effects when associated with antibiotics were studied. Extracts from the following plants were utilized: Achillea millifolium (yarrow), Caryophyllus aromaticus (clove), Melissa offficinalis (lemon-balm), Ocimun basilucum (basil), Psidium guajava (guava), Punica granatum (pomegranate), Rosmarinus officinalis (rosemary), Sa...

  15. Antibacterial Activity of Medicinal Plants Against Pathogens causing Complicated Urinary Tract Infections

    Sharma Anjana; Chandraker S; Patel V; Ramteke Padmini

    2009-01-01

    Seventeen Indian folklore medicinal plants were investigated to evaluate antibacterial activity of aqueous, ethanol and acetone extracts against 66 multidrug resistant isolates of major urinary tract pathogens ( Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa and Enterococcus faecalis ) by disc diffusion method. Ethanol extract of Zingiber officinale and Punica granatum showed strong antibacterial activity against Escherichia coli. Ethanol extracts of Terminalia chebu...

  16. Metallic AdS/CFT

    We use the AdS/CFT correspondence to compute the conductivity of massive N = 2 hypermultiplet fields at finite baryon number density in an N = 4 SU(Nc) super-Yang-Mills theory plasma in the large Nc, large 't Hooft coupling limit. The finite baryon density provides charge carriers analogous to electrons in a metal. An external electric field then induces a finite current which we determine directly. Our result for the conductivity is good for all values of the mass, external field and density, modulo statements about the yet-incomplete phase diagram. In the appropriate limits it agrees with known results obtained from analyzing small fluctuations around equilibrium. For large mass, where we expect a good quasi-particle description, we compute the drag force on the charge carriers and find that the answer is unchanged from the zero density case. Our method easily generalizes to a wide class of systems of probe branes in various backgrounds

  17. Ad valorem versus unit taxes

    Schröder, Philipp J.H.; Sørensen, Allan

    2010-01-01

    Real-world industries are composed from heterogeneous firms and substantial intra-industry reallocations take place, i.e. high productivity firms squeeze out low productivity firms. Previous tax-tool comparisons have not included these central forces of industry structure. This paper examines a...... general equilibrium monopolistic competition model with heterogeneous firms and intra-industry reallocations. We show that the welfare superiority of ad valorem over unit taxes under imperfect competition is not only preserved but amplified. The additional difference between the tools arises because unit...... taxes distort relative prices, which in turn reduces average industry productivity through reallocations (the survival and increased market share of lower productivity firms). Importantly, numerical solutions of the model reveal that the relative welfare loss from using the unit tax increases...

  18. MUSICAL ARRANGEMENT OF MEDIA ADS

    Chernyshov Alexander V.

    2015-01-01

    Full Text Available The music-compositional principles of commercial and political advertising and also the self-promotion of electronic media (radio, television, Internet are considered in this mediatext: from the elementary beeps, symbolic functions, emblems/logos and musical brands to the sound engineering technology to underscore the product's name and the complex synthesis between music and intra movements and color-light design of frames. Simultaneously examines, how the musical arrangement of ethereal advertising is involved in creation the emotional drama or bravado which reach the level of explicit or associative counterpoint 'music with the advertised object or subject' and which extend to expression of cultural image of all the broadcast channel. The article explores the works of the next genres like infomercial, teleshopping, film-ad, and autonomous commercials that have been produced in European countries or USA.

  19. Thermodynamic and classical instability of AdS black holes in fourth-order gravity

    We study thermodynamic and classical instability of AdS black holes in fourth-order gravity. These include the BTZ black hole in new massive gravity, Schwarzschild-AdS black hole, and higher-dimensional AdS black holes in fourth-order gravity. All thermodynamic quantities which are computed using the Abbot-Deser-Tekin method are used to study thermodynamic instability of AdS black holes. On the other hand, we investigate the s-mode Gregory-Laflamme instability of the massive graviton propagating around the AdS black holes. We establish the connection between the thermodynamic instability and the GL instability of AdS black holes in fourth-order gravity. This shows that the Gubser-Mitra conjecture holds for AdS black holes found from fourth-order gravity

  20. Which AdS3 configurations contribute to the SCFT2 elliptic genus?

    Murthy, S.V.; Nawata, S.

    2011-01-01

    According to the AdS=CFT duality, the superconformal index of a superconformal eld theory should have an AdS interpretation as a Euclidean functional integral with periodic boundary conditions on the fermions. Unlike the thermal case, the Euclidean continuation of the supersymmetric AdS black hole d