WorldWideScience

Sample records for activity cycles

  1. Activity Cycle of Solar Filaments

    K. J. Li; Q. X. Li; P. X. Gao; J. Mu; H. D. Chen; T. W. Su

    2007-06-01

    Long-term variation in the distribution of the solar filaments observed at the Observatorie de Paris, Section de Meudon from March 1919 to December 1989 is presented to compare with sunspot cycle and to study the periodicity in the filament activity, namely the periods of the coronal activity with the Morlet wavelet used. It is inferred that the activity cycle of solar filaments should have the same cycle length as sunspot cycle, but the cycle behavior of solar filaments is globally similar in profile with, but different in detail from, that of sunspot cycles. The amplitude of solar magnetic activity should not keep in phase with the complexity of solar magnetic activity. The possible periods in the filament activity are about 10.44 and 19.20 years. The wavelet local power spectrum of the period 10.44 years is statistically significant during the whole consideration time. The wavelet local power spectrum of the period 19.20 years is under the 95% confidence spectrum during the whole consideration time, but over the mean red-noise spectrum of = 0.72 before approximate Carrington rotation number 1500, and after that the filament activity does not statistically show the period. Wavelet reconstruction indicates that the early data of the filament archive (in and before cycle 16) are more noiseful than the later (in and after cycle 17).

  2. Analysis of Sunspot Activity Cycles

    Greenkorn, Robert A.

    2009-04-01

    A nonlinear analysis of the daily sunspot number for each of cycles 10 to 23 is used to indicate whether the convective turbulence is stochastic or chaotic. There is a short review of recent papers considering sunspot statistics and solar activity cycles. The differences in the three possible regimes - deterministic laminar flow, chaotic flow, and stochastic flow - are discussed. The length of data sets necessary to analyze the regimes is investigated. Chaos is described and a chronology of recent results that utilize chaos and fractals to analyze sunspot numbers follows. The parameters necessary to describe chaos - time lag, phase space, embedding dimension, local dimension, correlation dimension, and the Lyapunov exponents - are determined for the attractor for each cycle. Assuming the laminar regime is unlikely if chaos is not indicated in a cycle by the calculations, the regime must be stochastic. The sunspot numbers in each of cycles 10 to 19 indicate stochastic behavior. There is a transition from stochastic to chaotic behavior of the sunspot numbers in cycles 20, 21, 22, and 23. These changes in cycles 20 - 23 may indicate a change in the scale of turbulence in the convection zone that could result in a change in the convective heat transfer and a change in the size of the convection region for these four cycles.

  3. Properties of stellar activity cycles

    Korhonen, Heidi

    2015-01-01

    The current photometric datasets, that span decades, allow for studying long-term cycles on active stars. Complementary Ca H&K observations give information also on the cycles of normal solar-like stars, which have significantly smaller, and less easily detectable, spots. In the recent years, high precision space-based observations, for example from the Kepler satellite, have allowed also to study the sunspot-like spot sizes in other stars. Here I review what is known about the properties of the cyclic stellar activity in other stars than our Sun.

  4. Activity cycles of M dwarfs

    Savanov, I. S.

    2012-09-01

    We have determined activity cycles for coolest M dwarfs using photometry from the ASAS survey. The time scales of brightness variations were determined for the program stars using calculated amplitude power spectra and wavelet spectra. Most of ther program stars display periodicities in their light-curve variations, with periods from hundreds of days to years. Analysis of diagrams plotting P cyc/ P rot versus 1/ P rot in logarithmic coordinates shows that the data for all our program objects fit the general relation quite well. No differences in the activity cycles are found for our sample stars, which have different masses and thus internal structures, some having convective envelopes and others being totally convective. Our analysis indicates that the slope i of this relation is close to unity, regardless of whether it is determined from all data, from data for the shortest cycles, or from data for the longest cycles. This value of i differs from values in the literature for stars of other spectral types. Our analysis of the P cyc- P rot relation indicates that the activity cycles for the studied sample of M dwarfs do not depend on the rotation periods of these objects. The data for the studied objects do not agree with any of the relations for relatively young (active) stars or older (less active) stars. The studied M dwarfs probably form another branch of low-mass stars that display more random, irregular magnetic activity on their surfaces, which is generated and supported by the distributed dynamo mechanism or a small-scale dynamo mechanism.

  5. Properties of stellar activity cycles

    Korhonen, Heidi

    2015-01-01

    The current photometric datasets, that span decades, allow for studying long-term cycles on active stars. Complementary Ca H&K observations give information also on the cycles of normal solar-like stars, which have significantly smaller, and less easily detectable, spots. In the recent years, high precision space-based observations, for example from the Kepler satellite, have allowed also to study the sunspot-like spot sizes in other stars. Here I review what is known about the properties of ...

  6. IAEA activities on nuclear fuel cycle 1997

    The presentation discussing the IAEA activities on nuclear fuel cycle reviews the following issues: organizational charts of IAEA, division of nuclear power and the fuel cycle, nuclear fuel cycle and materials section; 1997 budget estimates; budget trends; the nuclear fuel cycle programme

  7. When Product Life Cycle Meets Customer Activity Cycle

    Tan, Adrian Ronald

    2007-01-01

    Manufacturing companies have traditionally focused their efforts on designing, developing and producing products to offer on the market. Today global competition and demands for greater company responsibility of products throughout their entire life cycle are driving manufacturing companies to...... products throughout their life cycle by designing integrated solutions of products and services. This approach has been dubbed ‘product/service-systems (PSS)’ (Mont, 2004). Although relationship marketing and product/service-system design have their roots in each their own research fields - marketing and...... engineering design - it seems that the two approaches are complimentary. The principle behind PSS is a shift from a perception that value is mainly embedded in a physical artefact to a perception where the activities associated with the product are considered to be a better definition of value. In this new...

  8. Global water cycle and solar activity variations

    Al-Tameemi, Muthanna A.; Chukin, Vladimir V.

    2016-05-01

    The water cycle is the most active and most important component in the circulation of global mass and energy in the Earth system. Furthermore, water cycle parameters such as evaporation, precipitation, and precipitable water vapour play a major role in global climate change. In this work, we attempt to determine the impact of solar activity on the global water cycle by analyzing the global monthly values of precipitable water vapour, precipitation, and the Solar Modulation Potential in 1983-2008. The first object of this study was to calculate global evaporation for the period 1983-2008. For this purpose, we determined the water cycle rate from satellite data, and precipitation/evaporation relationship from 10 years of Planet Simulator model data. The second object of our study was to investigate the relationship between the Solar Modulation Potential (solar activity index) and the evaporation for the period 1983-2008. The results showed that there is a relationship between the solar modulation potential and the evaporation values for the period of study. Therefore, we can assume that the solar activity has an impact on the global water cycle.

  9. Forecasting the solar activity cycle: new insights

    Nandy, Dibyendu; Karak, Bidya Binay

    2013-01-01

    Having advanced knowledge of solar activity is important because the Sun's magnetic output governs space weather and impacts technologies reliant on space. However, the irregular nature of the solar cycle makes solar activity predictions a challenging task. This is best achieved through appropriately constrained solar dynamo simulations and as such the first step towards predictions is to understand the underlying physics of the solar dynamo mechanism. In Babcock-Leighton type dynamo models, ...

  10. Forecasting the solar activity cycle: new insights

    Nandy, Dibyendu

    2013-01-01

    Having advanced knowledge of solar activity is important because the Sun's magnetic output governs space weather and impacts technologies reliant on space. However, the irregular nature of the solar cycle makes solar activity predictions a challenging task. This is best achieved through appropriately constrained solar dynamo simulations and as such the first step towards predictions is to understand the underlying physics of the solar dynamo mechanism. In Babcock-Leighton type dynamo models, the poloidal field is generated near the solar surface whereas the toroidal field is generated in the solar interior. Therefore a finite time is necessary for the coupling of the spatially segregated source layers of the dynamo. This time delay introduces a memory in the dynamo mechanism which allows forecasting of future solar activity. Here we discuss how this forecasting ability of the solar cycle is affected by downward turbulent pumping of magnetic flux. With significant turbulent pumping the memory of the dynamo is ...

  11. POSSIBLE CHROMOSPHERIC ACTIVITY CYCLES IN AD LEO

    Buccino, Andrea P.; Petrucci, Romina; Mauas, Pablo J. D. [Instituto de Astronomía y Física del Espacio (CONICET-UBA), C.C. 67 Sucursal 28, C1428EHA-Buenos Aires (Argentina); Jofré, Emiliano [Observatorio Astronómico de Córdoba, Córdoba (Argentina)

    2014-01-20

    AD Leo (GJ 388) is an active dM3 flare star that has been extensively observed both in the quiescent and flaring states. Since this active star is near the fully convective boundary, studying its long-term chromospheric activity in detail could be an appreciable contribution to dynamo theory. Here, using the Lomb-Scargle periodogram, we analyze the Ca II K line-core fluxes derived from CASLEO spectra obtained between 2001 and 2013 and the V magnitude from the ASAS database between 2004 and 2010. From both of these totally independent time series, we obtain a possible activity cycle with a period of approximately seven years and a less significant shorter cycle of approximately two years. A tentative interpretation is that a dynamo operating near the surface could be generating the longer cycle, while a second dynamo operating in the deep convection zone could be responsible for the shorter one. Based on the long duration of our observing program at CASLEO and the fact that we observe different spectral features simultaneously, we also analyze the relation between simultaneous measurements of the Na I index (R{sub D}{sup ′}), Hα, and Ca II K fluxes at different activity levels of AD Leo, including flares.

  12. POSSIBLE CHROMOSPHERIC ACTIVITY CYCLES IN AD LEO

    AD Leo (GJ 388) is an active dM3 flare star that has been extensively observed both in the quiescent and flaring states. Since this active star is near the fully convective boundary, studying its long-term chromospheric activity in detail could be an appreciable contribution to dynamo theory. Here, using the Lomb-Scargle periodogram, we analyze the Ca II K line-core fluxes derived from CASLEO spectra obtained between 2001 and 2013 and the V magnitude from the ASAS database between 2004 and 2010. From both of these totally independent time series, we obtain a possible activity cycle with a period of approximately seven years and a less significant shorter cycle of approximately two years. A tentative interpretation is that a dynamo operating near the surface could be generating the longer cycle, while a second dynamo operating in the deep convection zone could be responsible for the shorter one. Based on the long duration of our observing program at CASLEO and the fact that we observe different spectral features simultaneously, we also analyze the relation between simultaneous measurements of the Na I index (RD′), Hα, and Ca II K fluxes at different activity levels of AD Leo, including flares

  13. The Heliosphere through the Solar Activity Cycle

    Balogh, André; Suess, Steven T

    2008-01-01

    Understanding how the Sun changes though its 11-year sunspot cycle and how these changes affect the vast space around the Sun – the heliosphere – has been one of the principal objectives of space research since the advent of the space age. This book presents the evolution of the heliosphere through an entire solar activity cycle. The last solar cycle (cycle 23) has been the best observed from both the Earth and from a fleet of spacecraft. Of these, the joint ESA-NASA Ulysses probe has provided continuous observations of the state of the heliosphere since 1990 from a unique vantage point, that of a nearly polar orbit around the Sun. Ulysses’ results affect our understanding of the heliosphere from the interior of the Sun to the interstellar medium - beyond the outer boundary of the heliosphere. Written by scientists closely associated with the Ulysses mission, the book describes and explains the many different aspects of changes in the heliosphere in response to solar activity. In particular, the authors...

  14. The Heliosphere Through the Solar Activity Cycle

    Balogh, A.; Lanzerotti, L. J.; Suess, S. T.

    2006-01-01

    Understanding how the Sun changes though its 11-year sunspot cycle and how these changes affect the vast space around the Sun the heliosphere has been one of the principal objectives of space research since the advent of the space age. This book presents the evolution of the heliosphere through an entire solar activity cycle. The last solar cycle (cycle 23) has been the best observed from both the Earth and from a fleet of spacecraft. Of these, the joint ESA-NASA Ulysses probe has provided continuous observations of the state of the heliosphere since 1990 from a unique vantage point, that of a nearly polar orbit around the Sun. Ulysses results affect our understanding of the heliosphere from the interior of the Sun to the interstellar medium - beyond the outer boundary of the heliosphere. Written by scientists closely associated with the Ulysses mission, the book describes and explains the many different aspects of changes in the heliosphere in response to solar activity. In particular, the authors describe the rise in solar ESA and NASA have now unamiously agreed a third extension to operate the highly successful Ulysses spacecraft until March 2008 and, in 2007 and 2008, the European-built space probe will fly over the poles of the Sun for a third time. This will enable Ulysses to add an important chapter to its survey of the high-latitude heliosphere and this additional material would be included in a 2nd edition of this book.

  15. Recent Advances in GEO Water Cycle Activities

    Lawford, R. G.

    2009-12-01

    Over the past few years GEO (Group on Earth Observations) efforts within the Water Societal Benefit Area (SBA) have been coordinated by the Science Committee of the former Integrated Global Observing Strategy Partnership (IGOS-P) IGWCO (Integrated Global Water Cycle Observations) theme. Within this framework a number of projects related to data system design, product development, and capacity building are being carried out. GEO has recently consolidated the Water SBA activities into three tasks, namely Droughts, Floods and Water Resource Management; Capacity Building for Water Resource Management (in Asia, Africa and the Americas); and Integrated Products for Water Resource Management and Research. In order to strengthen interactions with the GEO and its User Interface Committee, a Water Cycle Community of Practice (COP) was initiated. In addition, within the past year, the IGWCO Science Committee has decided to also function as a Community of Practice in collaboration with the existing Water Cycle COP. This overview will provide background and an update on the GEO Water SBA activities with an emphasis of the way in which these activities are being integrated within the three tasks. It will also describe activities that are planned for 2010 to facilitate this integration. Recent advances related to drought monitoring, capacity and network building, and observational and data systems will be highlighted. New water-related activities arising from collaborations between US GEO and Canada GEO, and through activities within the GEO Architecture and Data Committee, will also be described. This presentation will conclude with a longer-term outlook for water within the GEO framework and provide some guidance for interested experts on how they can become involved in helping to implement these plans.

  16. Stochastic cycle selection in active flow networks.

    Woodhouse, Francis G; Forrow, Aden; Fawcett, Joanna B; Dunkel, Jörn

    2016-07-19

    Active biological flow networks pervade nature and span a wide range of scales, from arterial blood vessels and bronchial mucus transport in humans to bacterial flow through porous media or plasmodial shuttle streaming in slime molds. Despite their ubiquity, little is known about the self-organization principles that govern flow statistics in such nonequilibrium networks. Here we connect concepts from lattice field theory, graph theory, and transition rate theory to understand how topology controls dynamics in a generic model for actively driven flow on a network. Our combined theoretical and numerical analysis identifies symmetry-based rules that make it possible to classify and predict the selection statistics of complex flow cycles from the network topology. The conceptual framework developed here is applicable to a broad class of biological and nonbiological far-from-equilibrium networks, including actively controlled information flows, and establishes a correspondence between active flow networks and generalized ice-type models. PMID:27382186

  17. Stochastic cycle selection in active flow networks

    Woodhouse, Francis G; Fawcett, Joanna B; Dunkel, Jörn

    2016-01-01

    Active biological flow networks pervade nature and span a wide range of scales, from arterial blood vessels and bronchial mucus transport in humans to bacterial flow through porous media or plasmodial shuttle streaming in slime molds. Despite their ubiquity, little is known about the self-organization principles that govern flow statistics in such non-equilibrium networks. Here we connect concepts from lattice field theory, graph theory, and transition rate theory to understand how topology controls dynamics in a generic model for actively driven flow on a network. Our combined theoretical and numerical analysis identifies symmetry-based rules that make it possible to classify and predict the selection statistics of complex flow cycles from the network topology. The conceptual framework developed here is applicable to a broad class of non-biological far-from-equilibrium networks, including actively controlled information flows, and establishes a new correspondence between active flow networks and generalized ...

  18. GEO Water Cycle Activities and Plans

    Lawford, R.; Koike, T.; Ishida, C.; Grabs, W.

    2008-12-01

    The Group on Earth Observations (GEO) consists of more than 70 countries and 40 international organizations which are working together to develop the Global Earth Observation System of Systems (GEOSS). Since its launch in 2004, GEO has stimulated a wide range of activities related to data systems and their architecture, the development of science and technology to support observational programs, user interactions and interfaces, and capacity building. GEO tasks directed at Water Resources Management, one of the nine GEO Societal Benefit areas, are an integral part of these developments. They draw heavily upon the activities of the Integrated Global Water Cycle Observations (IGWCO) theme and on the activities and infrastructure provided through GEO and its committees. Within the GEO framework the water related activities have been focused on four specific tasks namely integrated data set development; information for floods, droughts and water management; water quality, and capacity building. Currently these efforts are being facilitated by the IGWCO theme that was formed under the former Integrated Global Observing Strategy Partnership (IGOS-P). With the dissolution of this partnership, other mechanisms, including the GEO Water Cycle Community of Practice, are being considered as new opportunitites for coordinating the work of the theme and the water-related GEO tasks. This talk provides a description of the GEO water tasks and reviews the progress that has been made in addressing them. It also provides a perspective on new opportunities and briefly describes some of the mechanisms, such as the Water Cycle Community of Practice, that could be expanded to coordinate a more comprehensive set of water tasks and greater community involvement.

  19. Coronal Activity and Extended Solar Cycles

    Altrock, R. C.

    2012-12-01

    Wilson et al. (1988, Nature 333, 748) discussed a number of solar parameters, which appear at high latitudes and gradually migrate towards the equator, merging with the sunspot "butterfly diagram". They found that this concept had been identified by earlier investigators extending back to 1957. They named this process the "Extended Solar Cycle" (ESC). Altrock (1997, Solar Phys. 170, 411) found that this process continued in Fe XIV 530.3 nm emission features. In cycles 21 - 23 solar maximum occurred when the number of Fe XIV emission regions per day > 0.19 (averaged over 365 days and both hemispheres) first reached latitudes 18°, 21° and 21°, for an average of 20° ± 1.7°. Other recent studies have shown that Torsional Oscillation (TO) negative-shear zones are co-located with the ESC from at least 50° down to the equator and also in the zones where the Rush to the Poles occur. These phenomena indicate that coronal activity occurring up to 50° and higher latitudes is related to TO shear zones, another indicator that the ESC is an important solar process. Another high-latitude process, which appears to be connected with the ESC, is the "Rush to the Poles" ("Rush") of polar crown prominences and their associated coronal emission, including Fe XIV. The Rush is is a harbinger of solar maximum (cf. Altrock, 2003, Solar Phys. 216, 343). Solar maximum in cycles 21 - 23 occurred when the center line of the Rush reached a critical latitude. These latitudes were 76°, 74° and 78°, respectively, for an average of 76° ± 2°. Applying the above conclusions to Cycle 24 is difficult due to the unusual nature of this cycle. Cycle 24 displays an intermittent "Rush" that is only well-defined in the northern hemisphere. In 2009 an initial slope of 4.6°/yr was found in the north, compared to an average of 9.4 ± 1.7 °/yr in the previous three cycles. This early fit to the Rush would have reached 76° at 2014.6. However, in 2010 the slope increased to 7.5°/yr (an increase

  20. When Product Life Cycle Meets Customer Activity Cycle

    Tan, Adrian Ronald

    2007-01-01

    Manufacturing companies have traditionally focused their efforts on designing, developing and producing products to offer on the market. Today global competition and demands for greater company responsibility of products throughout their entire life cycle are driving manufacturing companies to shift market strategies from a transactional approach to an approach based on the establishment and management of customer relationships (Grönroos, 1999). A growing number of studies and research progra...

  1. Ecological effects of fuel cycle activities

    The purpose of this paper is to summarize the approach used to characterize ecological impacts of the coal fuel cycle. The same approach is used for many of the impacts in other fuel cycles as well. The principal analytical approach being used in the study is an accounting framework - that is, a series of matrices that map each phase of the fuel cycle to a suite of possible. emissions, each emission to a suite of impact categories, and each impact category to an external cost. This paper summarizes the ecological impacts of all phases of the coal fuel cycle, defines the ecological impact categories used in the study's 'accounting framework', and discusses alternative approaches to quantification. Externalities associated with CO2-induced global climate change are beyond the scope of this paper and are not discussed

  2. Multiple and changing cycles of active stars II. Results

    Oláh, K; Granzer, T; Strassmeier, K G; Lanza, A F; Järvinen, S; Korhonen, H; Baliunas, S L; Soon, W; Messina, S; Cutispoto, G

    2009-01-01

    We study the time variations of the cycles of 20 active stars based on decades-long photometric or spectroscopic observations. A method of time-frequency analysis, as discussed in a companion paper, is applied to the data. Fifteen stars definitely show multiple cycles; the records of the rest are too short to verify a timescale for a second cycle. The cycles typically show systematic changes. For three stars, we found two cycles in each of them that are not harmonics, and which vary in parallel, indicating that a common physical mechanism arising from a dynamo construct. The positive relation between the rotational and cycle periods is confirmed for the inhomogeneous set of active stars. Stellar activity cycles are generally multiple and variable.

  3. Butterfly Diagram and Activity Cycles in HR 1099

    Berdyugina, S. V.; Henry, G. W.

    2007-01-01

    We analyze photometric data of the active RS CVn--type star HR 1099 for the years 1975--2006 with an inversion technique and reveal the nature of two activity cycles of 15--16 yr and 5.3$\\pm$0.1 yr duration. The 16 yr cycle is related to variations of the total spot area and is coupled with the differential rotation, while the 5.3 yr cycle is caused by the symmetric redistribution of the spotted area between the opposite stellar hemispheres (flip-flop cycle). We recover long-lived active regi...

  4. Forecasting the Peak of the Present Solar Activity Cycle

    Hamid, Rabab; Marzouk, Beshir

    2016-07-01

    Solar forecasting of the level of sun Activity is very important subject for all space programs. Most predictions are based on the physical conditions prevailing at or before the solar cycle minimum preceding the maximum in question. Our aim is to predict the maximum peak of cycle 24 using precursor techniques in particular those using spotless event, geomagnetic aa min. index and solar flux F10.7. Also prediction of exact date of the maximum (Tr) is taken in consideration. A study of variation over previous spotless event for cycles 7-23 and that for even cycles (8-22) are carried out for the prediction. Linear correlation between RM and spotless event around the preceding minimum gives RM24t = 101.9with rise time Tr = 4.5 Y. For the even cycles RM24e = 108.3 with rise time Tr = 3.9 Y. Based on the average aa min. index for the year of sunspot minimum cycles (13 - 23), we estimate the expected amplitude for cycle 24 to be RMaa = 116.5 for both the total and even cycles. Application of the data of solar flux F10.7 which cover only cycles (19-23) was taken in consideration and gives predicted maximum amplitude R24 10.7 = 146, which are over estimation. Our result indicating a somewhat weaker cycle 24 as compared to cycles 21-23.

  5. Junction temperature estimation for an advanced active power cycling test

    Choi, Uimin; Blaabjerg, Frede; Jørgensen, S.

    estimation method using on-state VCE for an advanced active power cycling test is proposed. The concept of the advanced power cycling test is explained first. Afterwards the junction temperature estimation method using on-state VCE and current is presented. Further, the method to improve the accuracy of the...

  6. The connection between stellar activity cycles and magnetic field topology

    See, V.; Jardine, M.; Vidotto, A. A.; Donati, J.-F.; Boro Saikia, S.; Bouvier, J.; Fares, R.; Folsom, C. P.; Gregory, S. G.; Hussain, G.; Jeffers, S. V.; Marsden, S. C.; Morin, J.; Moutou, C.; do Nascimento, J. D.; Petit, P.; Waite, I. A.

    2016-08-01

    Zeeman Doppler imaging has successfully mapped the large-scale magnetic fields of stars over a large range of spectral types, rotation periods and ages. When observed over multiple epochs, some stars show polarity reversals in their global magnetic fields. On the Sun, polarity reversals are a feature of its activity cycle. In this paper, we examine the magnetic properties of stars with existing chromospherically determined cycle periods. Previous authors have suggested that cycle periods lie on multiple branches, either in the cycle period-Rossby number plane or the cycle period-rotation period plane. We find some evidence that stars along the active branch show significant average toroidal fields that exhibit large temporal variations while stars exclusively on the inactive branch remain dominantly poloidal throughout their entire cycle. This lends credence to the idea that different shear layers are in operation along each branch. There is also evidence that the short magnetic polarity switches observed on some stars are characteristic of the inactive branch while the longer chromospherically determined periods are characteristic of the active branch. This may explain the discrepancy between the magnetic and chromospheric cycle periods found on some stars. These results represent a first attempt at linking global magnetic field properties obtained form ZDI and activity cycles.

  7. Butterfly Diagram and Activity Cycles in HR 1099

    Berdyugina, Svetlana V.; Henry, Gregory W.

    2007-04-01

    We analyze photometric data of the active RS CVn-type star HR 1099 for the years 1975-2006 with an inversion technique and reveal the nature of two activity cycles of 15-16 yr and 5.3+/-0.1 yr duration. The 16 yr cycle is related to variations of the total spot area and is coupled with the differential rotation, while the 5.3 yr cycle is caused by the symmetric redistribution of the spotted area between the opposite stellar hemispheres (flip-flop cycle). We recover long-lived active regions comprising two active longitudes that migrate in the orbital reference frame with a variable rate because of the differential rotation along with changes in the mean spot latitudes. The migration pattern is periodic with the 16 yr cycle. Combining the longitudinal migration of the active regions with a previously measured differential rotation law, we recover the first stellar butterfly diagram without an assumption about spot shapes. We find that mean latitudes of active regions at opposite longitudes change antisymmetrically in the course of the 16 yr cycle: while one active region migrates to the pole, the other approaches the equator. This suggests a precession of the global magnetic field with respect to the stellar rotational axis.

  8. Stellar Magnetic Dynamos and Activity Cycles

    Wright, Nicholas J

    2013-01-01

    Using a new uniform sample of 824 solar and late-type stars with measured X-ray luminosities and rotation periods we have studied the relationship between rotation and stellar activity that is believed to be a probe of the underlying stellar dynamo. Using an unbiased subset of the sample we calculate the power law slope of the unsaturated regime of the activity -- rotation relationship as $L_X/L_{bol}\\propto Ro^\\beta$, where $\\beta=-2.70\\pm0.13$. This is inconsistent with the canonical $\\beta = -2$ slope to a confidence of 5$\\sigma$ and argues for an interface-type dynamo. We map out three regimes of coronal emission as a function of stellar mass and age, using the empirical saturation threshold and theoretical super-saturation thresholds. We find that the empirical saturation timescale is well correlated with the time at which stars transition from the rapidly rotating convective sequence to the slowly rotating interface sequence in stellar spin-down models. This may be hinting at fundamental changes in the ...

  9. Butterfly Diagram and Activity Cycles in HR 1099

    Berdyugina, S V

    2007-01-01

    We analyze photometric data of the active RS CVn--type star HR 1099 for the years 1975--2006 with an inversion technique and reveal the nature of two activity cycles of 15--16 yr and 5.3$\\pm$0.1 yr duration. The 16 yr cycle is related to variations of the total spot area and is coupled with the differential rotation, while the 5.3 yr cycle is caused by the symmetric redistribution of the spotted area between the opposite stellar hemispheres (flip-flop cycle). We recover long-lived active regions comprising two active longitudes that migrate in the orbital reference frame with a variable rate because of the differential rotation along with changes in the mean spot latitudes. The migration pattern is periodic with the 16 yr cycle. Combining the longitudinal migration of the active regions with a previously measured differential rotation law, we recover the first stellar butterfly diagram without an assumption about spot shapes. We find that mean latitudes of active regions at opposite longitudes change antisymm...

  10. Solar Rotation Rate During the Cycle 24 Minimum in Activity

    Antia, H. M.; Basu, Sarbani

    2010-01-01

    The minimum of solar cycle 24 is significantly different from most other minima in terms of its duration as well as its abnormally low levels of activity. Using available helioseismic data that cover epochs from the minimum of cycle 23 to now, we study the differences in the nature of the solar rotation between the minima of cycles 23 and 24. We find that there are significant differences between the rotation rates during the two minima. There are differences in the zonal-flow pattern too. We...

  11. A quest for activity cycles in low mass stars

    Vida, K; Oláh, K

    2013-01-01

    Long-term photometric measurements in a sample of ultrashort-period (P~0.5 days or less) single and binary stars of different interior structures are analysed. A loose correlation exists between the rotational rate and cycle lengths of active stars, regardless of their evolutionary state and the corresponding physical parameters. The shortest cycles are expected on the fastest rotators in the order of 1-2 years, which is reported in this paper.

  12. Radio Imaging Observations of Solar Activity Cycle and Its Anomaly

    Shibasaki, K.

    2011-12-01

    The 24th solar activity cycle has started and relative sunspot numbers are increasing. However, their rate of increase is rather slow compared to previous cycles. Active region sizes are small, lifetime is short, and big (X-class) flares are rare so far. We study this anomalous situation using data from Nobeyama Radioheliograph (NoRH). Radio imaging observations have been done by NoRH since 1992. Nearly 20 years of daily radio images of the Sun at 17 GHz are used to synthesize a radio butterfly diagram. Due to stable operation of the instrument and a robust calibration method, uniform datasets are available covering the whole period of observation. The radio butterfly diagram shows bright features corresponding to active region belts and their migration toward low latitude as the solar cycle progresses. In the present solar activity cycle (24), increase of radio brightness is delayed and slow. There are also bright features around both poles (polar brightening). Their brightness show solar cycle dependence but peaks around solar minimum. Comparison between the last minimum and the previous one shows decrease of its brightness. This corresponds to weakening of polar magnetic field activity between them. In the northern pole, polar brightening is already weakened in 2011, which means it is close to solar maximum in the northern hemisphere. Southern pole does not show such feature yet. Slow rise of activity in active region belt, weakening of polar activity during the minimum, and large north-south asymmetry in polar activity imply that global solar activity and its synchronization are weakening.

  13. Cycle-by-cycle assembly of respiratory network activity is dynamic and stochastic

    Carroll, Michael S.; Ramirez, Jan-Marino

    2012-01-01

    Rhythmically active networks are typically composed of neurons that can be classified as silent, tonic spiking, or rhythmic bursting based on their intrinsic activity patterns. Within these networks, neurons are thought to discharge in distinct phase relationships with their overall network output, and it has been hypothesized that bursting pacemaker neurons may lead and potentially trigger cycle onsets. We used multielectrode recording from 72 experiments to test these ideas in rhythmically ...

  14. MAGNETIC ACTIVITY CYCLES IN THE EXOPLANET HOST STAR {epsilon} ERIDANI

    Metcalfe, T. S.; Mathur, S. [Space Science Institute, 4750 Walnut Street, Suite 205, Boulder, CO 80301 (United States); Buccino, A. P.; Mauas, P. J. D.; Petrucci, R. [Instituto de Astronomia y Fisica del Espacio (CONICET), C.C. 67 Sucursal 28, C1428EHA-Buenos Aires (Argentina); Brown, B. P. [Department of Astronomy and Center for Magnetic Self-Organization, University of Wisconsin, Madison, WI 53706-1582 (United States); Soderblom, D. R. [Space Telescope Science Institute, 3700 San Martin Dr., Baltimore, MD 21218 (United States); Henry, T. J. [Department of Physics and Astronomy, Georgia State University, Atlanta, GA 30302 (United States); Hall, J. C. [Lowell Observatory, 1400 West Mars Hill Road, Flagstaff, AZ 86001 (United States); Basu, S. [Department of Astronomy, Yale University, P.O. Box 208101, New Haven, CT 06520 (United States)

    2013-02-01

    The active K2 dwarf {epsilon} Eri has been extensively characterized both as a young solar analog and more recently as an exoplanet host star. As one of the nearest and brightest stars in the sky, it provides an unparalleled opportunity to constrain stellar dynamo theory beyond the Sun. We confirm and document the 3-year magnetic activity cycle in {epsilon} Eri originally reported by Hatzes and coworkers, and we examine the archival data from previous observations spanning 45 years. The data show coexisting 3-year and 13-year periods leading into a broad activity minimum that resembles a Maunder minimum-like state, followed by the resurgence of a coherent 3-year cycle. The nearly continuous activity record suggests the simultaneous operation of two stellar dynamos with cycle periods of 2.95 {+-} 0.03 years and 12.7 {+-} 0.3 years, which, by analogy with the solar case, suggests a revised identification of the dynamo mechanisms that are responsible for the so-called 'active' and 'inactive' sequences as proposed by Boehm-Vitense. Finally, based on the observed properties of {epsilon} Eri, we argue that the rotational history of the Sun is what makes it an outlier in the context of magnetic cycles observed in other stars (as also suggested by its Li depletion), and that a Jovian-mass companion cannot be the universal explanation for the solar peculiarities.

  15. A 12-Year Activity Cycle for HD 219134

    Johnson, Marshall C; Cochran, William D; Meschiari, Stefano; Robertson, Paul; MacQueen, Phillip J; Brugamyer, Erik J; Caldwell, Caroline; Hatzes, Artie P; Ramírez, Ivan; Wittenmyer, Robert A

    2016-01-01

    The nearby (6.5 pc) star HD 219134 was recently shown by Motalebi et al. (2015) and Vogt et al. (2015) to host several planets, the innermost of which is transiting. We present twenty-seven years of radial velocity observations of this star from the McDonald Observatory Planet Search program, and nineteen years of stellar activity data. We detect a long-period activity cycle measured in the Ca II $S_{HK}$ index, with a period of $4230 \\pm 100$ days (11.7 years), very similar to the 11-year Solar activity cycle. Although the period of the Saturn-mass planet HD 219134 h is close to half that of the activity cycle, we argue that it is not an artifact due to stellar activity. We also find a significant periodicity in the $S_{HK}$ data due to stellar rotation with a period of 22.8 days. This is identical to the period of planet f identified by Vogt et al. (2015), suggesting that this radial velocity signal might be caused by rotational modulation of stellar activity rather than a planet. Analysis of our radial vel...

  16. Solar-Type Activity: Epochs of Cycle Formation

    Katsova, M M; Livshits, M A

    2015-01-01

    The diagram of indices of coronal and chromospheric activity allowed us to reveal stars where solar-type activity appears and regular cycles are forming. Using new consideration of a relation between coronal activity and the rotation rate, together with new data on the ages of open clusters, we estimate the age of the young Sun corresponding to the epoch of formation of its cycle. The properties of the activity of this young Sun, with an age slightly older than one billion years, are briefly discussed. An analysis of available data on the long-term regular variability of late-type stars leads to the conclusion that duration of a cycle associated with solar-type activity increases with the deceleration of the stellar rotation; i.e., with age. New data on the magnetic fields of comparatively young G stars and changes in the role of the large-scale and the local magnetic fields in the formation of the activity of the young Sun are discussed. Studies in this area aim to provide observational tests aimed at identi...

  17. The evolution and orientation of early cycle 22 active regions

    Cannon, Anne T.; Marquette, William H.

    1991-01-01

    The evolution of six major active regions which appeared during the first phase of the present solar cycle (cycle 22) has been studied. It was found that the northern hemisphere regions exhibited a broad range of evolutionary behavior in which the commonly accepted 'normal pattern' (whereby the follower flux moves preferentially polewards ahead of the leader flux) is represented at one end of the range. At the other end of the range, the leader flux is displaced polewards of the follower flux. In the latter cases equatorward extensions of the polar coronal hole are noted.

  18. The solar activity cycle physical causes and consequences

    Hudson, Hugh; Petrovay, Kristóf; Steiger, Rudolf

    2015-01-01

    A collection of papers edited by four experts in the field, this book sets out to describe the way solar activity is manifested in observations of the solar interior, the photosphere, the chromosphere, the corona and the heliosphere. The 11-year solar activity cycle, more generally known as the sunspot cycle, is a fundamental property of the Sun.  This phenomenon is the generation and evolution of magnetic fields in the Sun’s convection zone, the photosphere.  It is only by the careful enumeration and description of the phenomena and their variations that one can clarify their interdependences.   The sunspot cycle has been tracked back about four centuries, and it has been recognized that to make this data set a really useful tool in understanding how the activity cycle works and how it can be predicted, a very careful and detailed effort is needed to generate sunspot numbers.  This book deals with this topic, together with several others that present related phenomena that all indicate the physical pr...

  19. Magnetic Activity Cycles in the Exoplanet Host Star epsilon Eridani

    Metcalfe, T S; Brown, B P; Mathur, S; Soderblom, D R; Henry, T J; Mauas, P J D; Petrucci, R; Hall, J C; Basu, S

    2012-01-01

    The active K2 dwarf epsilon Eri has been extensively characterized, both as a young solar analog and more recently as an exoplanet host star. As one of the nearest and brightest stars in the sky, it provides an unparalleled opportunity to constrain stellar dynamo theory beyond the Sun. We confirm and document the 3 year magnetic activity cycle in epsilon Eri originally reported by Hatzes and coworkers, and we examine the archival data from previous observations spanning 45 years. The data show coexisting 3 year and 13 year periods leading into a broad activity minimum that resembles a Maunder minimum-like state, followed by the resurgence of a coherent 3 year cycle. The nearly continuous activity record suggests the simultaneous operation of two stellar dynamos with cycle periods of 2.95+/-0.03 years and 12.7+/-0.3 years, which by analogy with the solar case suggests a revised identification of the dynamo mechanisms that are responsible for the so-called "active" and "inactive" sequences as proposed by Bohm-V...

  20. Recent developments on fast reactor fuels and fuel cycle activities

    From the inception of nuclear energy, the important role of Sodium-Cooled Fast Reactor (SFR) and its fuel cycle has been recognized for efficient utilization of natural uranium and thorium resources and long-term sustainability of nuclear power. The IAEA initiated International Project on Innovative Reactor and Fuel Cycles (INPRO) and the US-DOE initiated Generation-IV International Forum (GIF) have also identified the importance of SFR and its fuel cycle in the 21st Century. One of the key factors for making SFR economically competitive with light water reactors (LWR) and pressurized heavy water reactors (PHWR) is to develop: i) a mixed uranium plutonium ceramic or metallic fuel, easy and economic to manufacture on an industrial scale, with high burn up (15-20,000 MWd/ton) and high breeding ratio and ii) a 'closed' fuel cycle where the spent fuel is subjected to efficient 'partitioning' process, based on either aqueous or pyro-electrolytic, for recovery of uranium, plutonium and minor actinides (Np, Am and Cm). The spent fuel and the actinides are highly radiotoxic and health hazardous and are required to be handled remotely inside alpha tight glove boxes or hot cells with beta-gamma and neutron shielding. The present paper summarizes the status of SFR fuels and fuel cycle activity all over the world highlighting the manufacturing technology of fuel and fuel structural materials and the different partitioning processes for separation of actinides

  1. A new simple dynamo model for stellar activity cycle

    Yokoi, Nobumitsu; Pipin, Valery; Hamba, Fujihiro

    2016-01-01

    A new simple dynamo model for stellar activity cycle is proposed. By considering an inhomogeneous mean flow effect on turbulence, it is shown that turbulent cross helicity (velocity--magnetic-field correlation) should enter the expression of turbulent electromotive force as the coupling coefficient for the mean absolute vorticity. The inclusion of the cross-helicity effect makes the present model different from the current $\\alpha$--$\\Omega$-type models mainly in two points. First, in addition to the usual $\\alpha$ (helicity effect) and $\\beta$ (turbulent magnetic diffusivity), we consider the $\\gamma$ coefficient (cross-helicity effect). Second, unlike the $\\alpha$ and $\\beta$ coefficients, which are often treated as an adjustable parameter in the current studies, the spatiotemporal evolution of $\\gamma$ coefficient should be solved simultaneously with the mean magnetic-field equations. The basic scenario for the stellar activity cycle in the present model is as follows: In the presence of turbulent cross he...

  2. Cdk Activity Couples Epigenetic Centromere Inheritance to Cell Cycle Progression

    Silva, Mariana C.C.; Bodor, Dani L.; Stellfox, Madison E.; Martins, Nuno M.C.; Hochegger, Helfrid; Foltz, Daniel R.; Jansen, Lars E.T.

    2012-01-01

    Centromeres form the site of chromosome attachment to microtubules during mitosis. Identity of these loci is maintained epigenetically by nucleosomes containing the histone H3 variant CENP-A. Propagation of CENP-A chromatin is uncoupled from DNA replication initiating only during mitotic exit. We now demonstrate that inhibition of Cdk1 and Cdk2 activities is sufficient to trigger CENP-A assembly throughout the cell cycle in a manner dependent on the canonical CENP-A assembly machinery. We fur...

  3. Recent development in safety regulation of nuclear fuel cycle activities

    Through the effort of deliberation and legislation over five years, Japanese government structure was reformed this January, with the aim of realizing simple, efficient and transparent administration. Under the reform, the Agency for Nuclear and Industrial Safety (ANIS) was founded in the Ministry of Economy, Trade and Industry (METI) to be responsible for safety regulation of energy-related nuclear activities, including nuclear fuel cycle activities, and industrial activities, including explosives, high-pressure gasses and mining. As one of the lessons learned from the JCO criticality accident of September 1999, it was pointed out that government's inspection function was not enough for fuel fabrication facilities. Accordingly, new statutory regulatory activities were introduced, namely, inspection of observance of safety rules and procedures for all kinds of nuclear operators and periodic inspection of fuel fabrication facilities. In addition, in order to cope with insufficient safety education and training of workers in nuclear facilities, licensees of nuclear facilities are required by law to specify safety education and training for their workers. ANIS is committed to enforce these new regulatory activities effectively and efficiently. In addition, it is going to be prepared for, in its capacity of safety regulatory authority, future development of Japanese fuel cycle activities, including commissioning of JNFL Rokkasho reprocessing plant and possible application for licenses for JNFL MOX fabrication plant and for spent fuel interim storage facilities. (author)

  4. Recent development in safety regulation of nuclear fuel cycle activities

    Through the effort of deliberation and legislation over five years, Japanese government structure was reformed this January, with the aim of realizing simple, efficient and transparent administration. Under the reform, the Agency for Nuclear and Industrial Safety (ANIS) was founded in the Ministry of Economy, Trade and Industry (METI) to be responsible for safety regulation of energy-related nuclear activities, including nuclear fuel cycle activities, and industrial activities, including explosives, high-pressure gasses and mining. As one of the lessons learned from the JCO criticality accident of September 1999, it was pointed out that the government's inspection function was not enough for fuel fabrication facilities. Accordingly, new statutory regulatory activities were introduced, namely, inspection of observance of safety rules and procedures for all kinds of nuclear operators and periodic inspection of fuel fabrication facilities. In addition, in order to cope with insufficient safety education and training of workers in nuclear facilities, licensees of nuclear facilities are required by law to specify safety education and training for their workers. ANIS is committed to enforce these new regulatory activities effectively and efficiently. In addition, it is going to be prepared, in its capacity as safety regulatory authority, for future development of Japanese fuel cycle activities, including commissioning of JNFL Rokkasho reprocessing plant and possible application for licenses for JNFL MOX fabrication plant and for spent fuel interim storage facilities. (author)

  5. Estrus cycle effect on muscle tyrosine kinase activity in bitches.

    Gomes Pöppl, Álan; Costa Valle, Sandra; Hilário Díaz González, Félix; de Castro Beck, Carlos Afonso; Kucharski, Luiz Carlos; Silveira Martins Da Silva, Roselis

    2012-03-01

    Estrus cycle is a well recognized cause of insulin resistance in bitches. The insulin receptor (IR) as well as the insulin-like growth factor-I receptor belong to the same subfamily of tyrosine kinase (TK) receptors. The objective of this study was to evaluate basal TK activity in muscle tissue of bitches during the estrus cycle. Twenty-four bitches were used in the study (7 in anestrus, 7 in estrus, and 10 in diestrus). Muscle samples, taken after spaying surgery to determine TK activity, were immediately frozen in liquid nitrogen and then stored at -80°C until the membranes were prepared by sequential centrifugation after being homogenized. TK activity was determined by Poly (Glu 4:Tyr 1) phosphorylation and expressed in cpm/μg of protein. TK activity was significantly lower (P < 0.001) in the animals in estrus (104.5 ± 11.9 cpm/μg of protein) and diestrus (94.5 ± 16.9 cpm/μg of protein) when compared with bitches in anestrus (183.2 ± 39.2 cpm/μg of protein). These results demonstrate, for the first time, lower basal TK activity in the muscle tissue of female dogs during estrus and diestrus, which may represent lower insulin signaling capacity, opening a new field of investigation into the molecular mechanisms of insulin resistance in dogs. PMID:22139063

  6. The Cell Cycle: An Activity Using Paper Plates to Represent Time Spent in Phases of the Cell Cycle

    Scherer, Yvette D.

    2014-01-01

    In this activity, students are given the opportunity to combine skills in math and geometry for a biology lesson in the cell cycle. Students utilize the data they collect and analyze from an online onion-root-tip activity to create a paper-plate time clock representing a 24-hour cell cycle. By dividing the paper plate into appropriate phases of…

  7. Short-period stellar activity cycles with Kepler photometry

    Arkhypov, Oleksiy V; Lammer, Helmut; Güdel, Manuel; Lüftinger, Theresa; Johnstone, Colin P

    2015-01-01

    We study the short-periodic component of stellar activity with a cycle periods Pcyc up to 1000 days using the Kepler mission photometry of fast-rotating (rotational periods from 1 to 4 days) stars with spectra of M4V to F3V. Applying the originally developed two non-spectral methods, we measured the effective period of stellar cycles in 462 objects. The obtained results are in accordance with previous measurements by Vida et al. (2014), do not seem to result from a beating effect. The performed measurements of Pcyc cluster in a specific branch which covers the previously unstudied region in the Saar-Brandenburg (1999) diagram, and connects the branch of inactive stars with the area populated by super-active objects. It is shown that the formation of the discovered branch is due to the alpha-quenching effect, which saturates the magnetic dynamo and decreases the cycle periods with the increase of inverted Rossby number. This finding is important in the context of the discussion on catastrophic quenching and ot...

  8. Energy Harvesting Cycles of Dielectric ElectroActive Polymer Generators

    Dimopoulos, Emmanouil; Trintis, Ionut; Munk-Nielsen, Stig

    2012-01-01

    Energy harvesting via Dielectric ElectroActive Polymer (DEAP) generators has attracted much of the scientific interest over the past few years, mainly due to the advantages that these smart materials offer against competing technologies, as electromagnetic generators and piezoelectrics. Their...... higher energy density, superior low-speed performance, light-weighted nature as well as their shapely structure have rendered DEAPs candidate solutions for various actuation and energy harvesting applications. In this paper, a thoroughly analysis of all energy harvesting operational cycles of a DEAP...

  9. Cardiovascular responses to active and passive cycling movements.

    Nóbrega, A C; Williamson, J W; Friedman, D B; Araújo, C G; Mitchell, J H

    1994-06-01

    Ten healthy subjects were evaluated at rest and at 5 min of unloaded active (AC) and passive (PC) cycling. Passive limb movements were accomplished using a tandem bicycle with a second rider performing the movements. We measured heart rate (HR), mean arterial pressure (MAP), cardiac output (CO), oxygen uptake (VO2), rating of perceived exertion (RPE), and electrical activity (EMG) of lower limbs muscles. Values for stroke volume (SV) and peripheral vascular resistance (PVR) were calculated. EMG, RPE, and VO2 were higher during AC than during PC (P < 0.001). CO increased during both modes of cycling, but during AC it resulted from a HR acceleration (73 +/- 2 at rest to 82 +/- 2 beats.min-1 at 60 rpm; P < 0.001) with no change in SV whereas during PC, SV increased from rest (65 +/- 4 at rest to 71 +/- 3 ml at 60 rpm; P = 0.003) along with no change in HR. PVR remained constant during PC, but decreased by 13% during AC (P < 0.001) and MAP increased only during PC (93 +/- 2 at rest to 107 +/- 2 mm Hg at 60 rpm). These results supports the concept that central command determines the HR response to dynamic exercise. The increase in SV and consequently in MAP during PC was probably due to increased venous return and/or to muscle mechanoreceptor-evoked increased myocardial contractility. PMID:8052111

  10. Annual cycle of photosynthetically active radiation in maritime pine forest

    In order to model the photosynthesis of an evergreen forest, knowledge of the seasonal variation in the photosynthetically active radiation (PAR) is indispensable. This paper studies the annual cycle of different components of the PAR above and within a maritime pine forest. From measurements of transmitted PAR made on days close to the solstices and the equinoxes, as well as continuous measurements of global and diffuse PAR throughout the year, the annual variation of PAR, within and above the forest was obtained. The relationship between the proportion of diffuse PAR to total PAR was also derived. The PAR reflectance above the canopy varied from 0.035 to 0.07 throughout the year. On clear sky days, roughly 65% of the incident PAR was absorbed by the needles, stems and branches and 20% was reflected; the remaining 15% was absorbed by the understorey. (author)

  11. A New Simple Dynamo Model for Stellar Activity Cycle

    Yokoi, N.; Schmitt, D.; Pipin, V.; Hamba, F.

    2016-06-01

    A new simple dynamo model for stellar activity cycle is proposed. By considering an inhomogeneous flow effect on turbulence, it is shown that turbulent cross helicity (velocity–magnetic-field correlation) enters the expression of turbulent electromotive force as the coupling coefficient for the mean absolute vorticity. This makes the present model different from the current α–Ω-type models in two main ways. First, in addition to the usual helicity (α) and turbulent magnetic diffusivity (β) effects, we consider the cross-helicity effect as a key ingredient of the dynamo process. Second, the spatiotemporal evolution of cross helicity is solved simultaneously with the mean magnetic fields. The basic scenario is as follows. In the presence of turbulent cross helicity, the toroidal field is induced by the toroidal rotation. Then, as in usual models, the α effect generates the poloidal field from the toroidal one. This induced poloidal field produces a turbulent cross helicity whose sign is opposite to the original one (negative production). With this cross helicity of the reversed sign, a reversal in field configuration starts. Eigenvalue analyses of the simplest possible model give a butterfly diagram, which confirms the above scenario and the equatorward migrations, the phase relationship between the cross helicity and magnetic fields. These results suggest that the oscillation of the turbulent cross helicity is a key for the activity cycle. The reversal of the cross helicity is not the result of the magnetic-field reversal, but the cause of the latter. This new model is expected to open up the possibility of the mean-field or turbulence closure dynamo approaches.

  12. The combined effect of cycling cadence and crank resistance on hamstrings and quadriceps muscle activities during cycling.

    Katona, P; Pilissy, T; Tihanyi, A; Laczkó, József

    2014-12-01

    The effect of cycling cadence and crank resistance on the activity of hamstrings and quadriceps muscles was investigated during cycling movements of able-bodied subjects on a stationary bike with slow and fast speed against different resistance conditions. The ratio of average EMG amplitudes obtained in the two speed conditions (fast/slow) was computed in each resistance condition. This ratio is higher for both muscles if cycling against higher resistance. This shows that in higher resistance condition muscle activities are not only increased but the change of muscle activities with respect to cadence change varied according to resistance condition. Average EMG amplitudes increased at a higher rate with respect to change of cadence when cycling was performed in higher resistance condition. Besides, when cycling faster, hamstrings activity increased generally at a higher rate than that of quadriceps. The correlation between cadence and EMG amplitudes were also investigated. Considering hamstrings, this correlation was low and decreased as resistance increased. The correlation between the time required to drive one cycle and EMG amplitude is negative but in absolute value it is larger than the correlation of cadence and EMG amplitude. PMID:25532958

  13. Exercise, physical activity, and exertion over the business cycle.

    Colman, Gregory; Dave, Dhaval

    2013-09-01

    Shifts in time and income constraints over economic expansions and contractions would be expected to affect individuals' behaviors. We explore the impact of the business cycle on individuals' exercise, time use, and total physical exertion, utilizing information on 112,000 individual records from the 2003-2010 American Time Use Surveys. In doing so, we test a key causal link that has been hypothesized in the relation between unemployment and health, but not heretofore assessed. Using more precise measures of exercise (and other activities) than previous studies, we find that as work-time decreases during a recession, recreational exercise, TV-watching, sleeping, childcare, and housework increase. This, however, does not compensate for the decrease in work-related exertion due to job-loss, and total physical exertion declines. These effects are strongest among low-educated men, which is validating given that employment in the Great Recession has declined most within manufacturing, mining, and construction. We also find evidence of intra-household spillover effects, wherein individuals respond to shifts in spousal employment conditional on their own labor supply. The decrease in total physical activity during recessions is especially problematic for vulnerable populations concentrated in boom-and-bust industries, and may have longer-term effects on obesity and related health outcomes. PMID:23906116

  14. A Solar Cycle Dependence of Nonlinearity in Magnetospheric Activity

    Johnson, Jay R; Wing, Simon

    2005-03-08

    The nonlinear dependencies inherent to the historical K(sub)p data stream (1932-2003) are examined using mutual information and cumulant based cost as discriminating statistics. The discriminating statistics are compared with surrogate data streams that are constructed using the corrected amplitude adjustment Fourier transform (CAAFT) method and capture the linear properties of the original K(sub)p data. Differences are regularly seen in the discriminating statistics a few years prior to solar minima, while no differences are apparent at the time of solar maximum. These results suggest that the dynamics of the magnetosphere tend to be more linear at solar maximum than at solar minimum. The strong nonlinear dependencies tend to peak on a timescale around 40-50 hours and are statistically significant up to one week. Because the solar wind driver variables, VB(sub)s and dynamical pressure exhibit a much shorter decorrelation time for nonlinearities, the results seem to indicate that the nonlinearity is related to internal magnetospheric dynamics. Moreover, the timescales for the nonlinearity seem to be on the same order as that for storm/ring current relaxation. We suggest that the strong solar wind driving that occurs around solar maximum dominates the magnetospheric dynamics suppressing the internal magnetospheric nonlinearity. On the other hand, in the descending phase of the solar cycle just prior to solar minimum, when magnetospheric activity is weaker, the dynamics exhibit a significant nonlinear internal magnetospheric response that may be related to increased solar wind speed.

  15. ANATOMY OF SOLAR CYCLE LENGTH AND SUNSPOT NUMBER: DEPENDENCE OF AVERAGE GLOBAL TEMPERATURE ON SOLAR ACTIVITY

    A. B. BHATTACHARYA

    2011-11-01

    Full Text Available The paper examines thoroughly all the past 23 sunspot cycles and the associated 11 hale cycles. It is noticed that solar cycle 23 had a deep minimum with longest decline phase. When solar cycles 20 to 23 are compared with solar cycles 1 to 4, the forthcoming Dalton minimum can be expected. The predicted variation of sunspot number for the present solar cycle 24 is examined at length and it appears that the peak monthly sunspot number of the solar cycle 24 will be around 80. We have correlated the solar cycle length and peak sunspot number witha priority to the solar cycle 24. From an elaborate analysis it appears that the most common cycle length is around 10.5 years, with few cycles in the range 11.5 to 12.5 years. Global temperature depends upon the total solar irradiance which in turn depends on duration of solar cycle. Also cloud cover directly depends on the solar irradiance. Our analysis supports that the global temperature is governed by the length of the predicted cycle.From the increased length of solar cycle 23, we have estimated the temperature variation of cycle 24. The predicted result reassures that average global temperature will be decreased for next few solar cycles due totypical solar activity. The results have been interpreted emphasizing the formation of type III solar radio bursts caused by plasma excitation.

  16. Solar Activity in Cycle 24 - What do Acoustic Oscillations tell us?

    Jain, Kiran; Tripathy, Sushant; Simoniello, Rosaria; Hill, Frank

    2016-05-01

    Solar Cycle 24 is the weakest cycle in modern era of space- and ground-based observations. The number of sunspots visible on solar disk and other measures of magnetic activity have significantly decreased from the last cycle. It was also preceeded by an extended phase of low activity, a period that raised questions on our understanding of the solar activity cycle and its origin. This unusual behavior was not only limited to the visible features in Sun's atmosphere, the helioseismic observations also revealed peculiar behavior in the interior. It was suggested that the changes in magnetic activity were confined to shallower layers only, as a result low-degree mode frequencies were found to be anti-correlated with solar activity. Here we present results on the progression of Cycle 24 by analyzing the uninterrupted helioseismic data from GONG and SDO/HMI, and discuss differences and similarity between cycles 23 and 24 in relation to the solar activity.

  17. Detecting activity cycles of late-type dwarfs in Kepler data

    Vida, K.; Oláh, K.

    2013-01-01

    Using data of fast-rotating active dwarf stars in the Kepler database, we perform time-frequency analysis of the light curves in order to search for signs of activity cycles. We use the phenomenon that the active region latitudes vary with the cycle (like the solar butterfly diagram), which causes the observed rotation period to change as a consequence of differential rotation. We find cycles in 8 cases of the 39 promising targets with periods between of 300-900 days.

  18. Increased activity of the glucose cycle in the liver: early characteristic of type 2 diabetes.

    Efendić, S; Wajngot, A; Vranić, M

    1985-01-01

    The aims were to assess in the mild, lean, type 2 diabetics the activity of the hepatic futile cycle (glucose cycling) in the basal state and during an infusion of glucose and the overall contribution of futile cycling and the relative contributions of the liver and the periphery to excessive hyperglycemia during a glucose challenge. To determine hepatic futile cycling, we studied seven healthy controls (C) and eight mild, lean, type 2 diabetics with decreased oral glucose tolerance test and ...

  19. Business cycles and leading indicators of industrial activity in India

    Mohanty, Jaya; Singh, Bhupal; Jain, Rajeev

    2003-01-01

    The identification of business cycles in India and construction of a composite leading indicator for forecasting the cyclical turning points have been the focus of this study. The cyclical analysis of monthly index of industrial production (IIP) in India applying the Bry-Boschan procedure indicates that there have been 13 growth cycles in the Indian economy with varying durations during 1970-71 to 2001-02. While the average duration of expansion has been 12 months, the recessions are characte...

  20. North-south asymmetry of solar dynamo in the current activity cycle

    Kitchatinov, L. L.; Khlystova, A. I.

    2014-01-01

    An explanation is suggested for the north-south asymmetry of the polar magnetic field reversal in the current cycle of solar activity. The contribution of the Babcock-Leighton mechanism to the poloidal field generation is estimated using sunspot data for the current activity cycle. Estimations are performed separately for the northern and southern hemispheres. The contribution of the northern hemisphere exceeded considerably that of the southern hemisphere during the initial stage of the cycl...

  1. Unusual migration of the prominence activities in the southern hemisphere during Cycle 23--24

    Shimojo, Masumi

    2013-01-01

    The solar activity in Cycle 23--24 shows differences from the previous cycles that were observed with modern instruments, e.g. long cycle duration and a small number of sunspots. To appreciate the anomalies further, we investigated the prominence eruptions and disappearances observed with the Nobeyama Radioheliograph during over 20 years. Consequently, we found that the occurrence of the prominence activities in the northern hemisphere is normal because the period of the number variation is 1...

  2. Protein Kinase C-Independent Activation of the Epstein-Barr Virus Lytic Cycle

    Gradoville, Lyndle; Kwa, David; El-Guindy, Ayman; Miller, George

    2002-01-01

    The protein kinase C (PKC) pathway has been considered to be essential for activation of latent Epstein-Barr virus (EBV) into the lytic cycle. The phorbol ester tetradecanoyl phorbol acetate (TPA), a PKC agonist, is one of the best understood activators of EBV lytic replication. Zp, the promoter of the EBV immediate-early gene BZLF1, whose product, ZEBRA, drives the lytic cycle, contains several phorbol ester response elements. We investigated the role of the PKC pathway in lytic cycle activa...

  3. Life cycle assessment of active and passive groundwater remediation technologies

    Bayer, Peter; Finkel, Michael

    2006-02-01

    Groundwater remediation technologies, such as pump-and-treat (PTS) and funnel-and-gate systems (FGS), aim at reducing locally appearing contaminations. Therefore, these methodologies are basically evaluated with respect to their capability to yield local improvements of an environmental situation, commonly neglecting that their application is also associated with secondary impacts. Life cycle assessment (LCA) represents a widely accepted method of assessing the environmental aspects and potential impacts related to a product, process or service. This study presents the set-up of a LCA framework in order to compare the secondary impacts caused by two conceptually different technologies at the site of a former manufactured gas plant in the city of Karlsruhe, Germany. As a FGS is already operating at this site, a hypothetical PTS of the same functionality is adopted. During the LCA, the remediation systems are evaluated by focusing on the main technical elements and their significance with respect to resource depletion and potential adverse effects on ecological quality, as well as on human health. Seven impact categories are distinguished to address a broad spectrum of possible environmental loads. A main point of discussion is the reliability of technical assumptions and performance predictions for the future. It is obvious that a high uncertainty exists when estimating impact specific indicator values over operation times of decades. An uncertainty analysis is conducted to include the imprecision of the underlying emission and consumption data and a scenario analysis is utilised to contrast various possible technological variants. Though the results of the study are highly site-specific, a generalised relative evaluation of potential impacts and their main sources is the principle objective rather than a discussion of the calculated absolute impacts. A crucial finding that can be applied to any other site is the central role of steel, which particularly derogates

  4. Staphylococcal Enterotoxin O Exhibits Cell Cycle Modulating Activity

    Hodille, Elisabeth; Alekseeva, Ludmila; Berkova, Nadia; Serrier, Asma; Badiou, Cedric; Gilquin, Benoit; Brun, Virginie; Vandenesch, François; Terman, David S.; Lina, Gerard

    2016-01-01

    Maintenance of an intact epithelial barrier constitutes a pivotal defense mechanism against infections. Staphylococcus aureus is a versatile pathogen that produces multiple factors including exotoxins that promote tissue alterations. The aim of the present study is to investigate the cytopathic effect of staphylococcal exotoxins SEA, SEG, SEI, SElM, SElN and SElO on the cell cycle of various human cell lines. Among all tested exotoxins only SEIO inhibited the proliferation of a broad panel of human tumor cell lines in vitro. Evaluation of a LDH release and a DNA fragmentation of host cells exposed to SEIO revealed that the toxin does not induce necrosis or apoptosis. Analysis of the DNA content of tumor cells synchronized by serum starvation after exposure to SEIO showed G0/G1 cell cycle delay. The cell cycle modulating feature of SEIO was confirmed by the flow cytometry analysis of synchronized cells exposed to supernatants of isogenic S. aureus strains wherein only supernatant of the SElO producing strain induced G0/G1 phase delay. The results of yeast-two-hybrid analysis indicated that SEIO’s potential partner is cullin-3, involved in the transition from G1 to S phase. In conclusion, we provide evidence that SEIO inhibits cell proliferation without inducing cell death, by delaying host cell entry into the G0/G1 phase of the cell cycle. We speculate that this unique cell cycle modulating feature allows SEIO producing bacteria to gain advantage by arresting the cell cycle of target cells as part of a broader invasive strategy. PMID:27148168

  5. Interglacials, Milankovitch Cycles, Solar Activity, and Carbon Dioxide

    Marsh, Gerald E.

    2014-01-01

    The existing understanding of interglacial periods is that they are initiated by Milankovitch cycles enhanced by rising atmospheric carbon dioxide concentrations. During interglacials, global temperature is also believed to be primarily controlled by carbon dioxide concentrations, modulated by internal processes such as the Pacific Decadal Oscillation and the North Atlantic Oscillation. Recent work challenges the fundamental basis of these conceptions.

  6. Relationship between geomagnetic classes’ activity phases and their occurrence during the sunspot cycle

    Frédéric Ouattara

    2009-06-01

    Full Text Available Four well known geomagnetic classes of activity such as quiet days activity, fluctuating activity, recurrent activity
    and shock activity time occurrences have been determined not only by using time profile of sunspot number
    Rz but also by using aa index values.
    We show that recurrent wind stream activity and fluctuating activity occur in opposite phase and slow solar wind
    activity during minimum phase and shock activity at the maximum phase.
    It emerges from this study that fluctuating activity precedes the sunspot cycle by π/2 and the latter also precedes
    recurrent activity by π/2. Thus in the majority the activities do not happen at random; the sunspot cycle starts
    with quiet days activity, continues with fluctuating activity and during its maximum phase arrives shock activity.
    The descending phase is characterized by the manifestation of recurrent wind stream activity.

  7. Prediction of solar activity from solar background magnetic field variations in cycles 21-23

    Shepherd, Simon J. [School of Engineering, University of Bradford, Bradford, BD7 1DP (United Kingdom); Zharkov, Sergei I. [Department of Physics and Mathematics, University of Hull, Kingston upon Tyne, HU6 7RS (United Kingdom); Zharkova, Valentina V., E-mail: s.j.shepherd@brad.ac.uk, E-mail: s.zharkov@hull.ac.uk, E-mail: valentina.zharkova@northumbria.ac.uk [Department of Mathematics and Information Systems, University of Northumbria, Newcastle upon Tyne, NE2 8ST (United Kingdom)

    2014-11-01

    A comprehensive spectral analysis of both the solar background magnetic field (SBMF) in cycles 21-23 and the sunspot magnetic field in cycle 23 reported in our recent paper showed the presence of two principal components (PCs) of SBMF having opposite polarity, e.g., originating in the northern and southern hemispheres, respectively. Over a duration of one solar cycle, both waves are found to travel with an increasing phase shift toward the northern hemisphere in odd cycles 21 and 23 and to the southern hemisphere in even cycle 22. These waves were linked to solar dynamo waves assumed to form in different layers of the solar interior. In this paper, for the first time, the PCs of SBMF in cycles 21-23 are analyzed with the symbolic regression technique using Hamiltonian principles, allowing us to uncover the underlying mathematical laws governing these complex waves in the SBMF presented by PCs and to extrapolate these PCs to cycles 24-26. The PCs predicted for cycle 24 very closely fit (with an accuracy better than 98%) the PCs derived from the SBMF observations in this cycle. This approach also predicts a strong reduction of the SBMF in cycles 25 and 26 and, thus, a reduction of the resulting solar activity. This decrease is accompanied by an increasing phase shift between the two predicted PCs (magnetic waves) in cycle 25 leading to their full separation into the opposite hemispheres in cycle 26. The variations of the modulus summary of the two PCs in SBMF reveals a remarkable resemblance to the average number of sunspots in cycles 21-24 and to predictions of reduced sunspot numbers compared to cycle 24: 80% in cycle 25 and 40% in cycle 26.

  8. Dose–response associations between cycling activity and risk of hypertension in regular cyclists: The UK Cycling for Health Study

    Hollingworth, M.; A Harper; Hamer, M.

    2014-01-01

    Most population studies on physical activity and health have involved largely inactive men and women, thus making it difficult to infer if health benefits occur at exercise levels above the current minimum guidelines. The aim was to examine associations between cycling volume and classical cardiovascular risk markers, including hypertension and hypercholesterolemia, in a population sample of habitual cyclists. A nationwide sample comprising 6949 men and women (aged 47.6 years on average) comp...

  9. Altered lower leg muscle activation patterns in patients with cerebral palsy during cycling on an ergometer

    Alves-Pinto, Ana; Blumenstein, Tobias; Turova, Varvara; Lampe, Renée

    2016-01-01

    Objective Cycling on a recumbent ergometer constitutes one of the most popular rehabilitation exercises in cerebral palsy (CP). However, no control is performed on how muscles are being used during training. Given that patients with CP present altered muscular activity patterns during cycling or walking, it is possible that an incorrect pattern of muscle activation is being promoted during rehabilitation cycling. This study investigated patterns of muscular activation during cycling on a recumbent ergometer in patients with CP and whether those patterns are determined by the degree of spasticity and of mobility. Methods Electromyographic (EMG) recordings of lower leg muscle activation during cycling on a recumbent ergometer were performed in 14 adult patients diagnosed with CP and five adult healthy participants. EMG recordings were done with an eight-channel EMG system built in the laboratory. The activity of the following muscles was recorded: Musculus rectus femoris, Musculus biceps femoris, Musculus tibialis anterior, and Musculus gastrocnemius. The degree of muscle spasticity and mobility was assessed using the Modified Ashworth Scale and the Gross Motor Function Classification System, respectively. Muscle activation patterns were described in terms of onset and duration of activation as well as duration of cocontractions. Results Muscle activation in CP was characterized by earlier onsets, longer periods of activation, a higher occurrence of agonist–antagonist cocontractions, and a more variable cycling tempo in comparison to healthy participants. The degree of altered muscle activation pattern correlated significantly with the degree of spasticity. Conclusion This study confirmed the occurrence of altered lower leg muscle activation patterns in patients with CP during cycling on a recumbent ergometer. There is a need to develop feedback systems that can inform patients and therapists of an incorrect muscle activation during cycling and support the training

  10. Unusual Migration of Prominence Activities in the Southern Hemisphere during Cycles 23-24

    Shimojo, Masumi

    2013-12-01

    The solar activity in Cycles 23-24 shows differences from the previous cycles that were observed with modern instruments, e.g., long cycle duration and a small number of sunspots. To appreciate the anomalies further, we investigated the prominence eruptions and disappearances observed with the Nobeyama Radioheliograph for over 20 years. Consequently, we found that the occurrence of prominence activities in the northern hemisphere is normal because the period of the number variation is 11 years, and the migration of the producing region of the prominence activities traces the migration of 11 years ago. On the other hand, the migration in the southern hemisphere significantly differs from that in the northern hemisphere and the previous cycles. The prominence activities occurred over -50° latitude in spite of the late decay phase of Cycle 23, and the number of prominence activities in the higher latitude region (over -65°) is very small, even near the solar maximum of Cycle 24. The results suggest that the anomalies of the global magnetic field distribution started at the solar maximum of Cycle 23. A comparison of the butterfly diagram of the prominence activities with the magnetic butterfly diagram indicates that the timing of "the rush to the pole" and the polar magnetic field closely relates to unusual migration. Considering that the rush to the pole is made of the sunspots, the hemispheric asymmetry of the sunspots and the strength of the polar magnetic fields are essential for understanding the anomalies of the prominence activities.

  11. Respiratory Muscle Activity During Simultaneous Stationary Cycling and Inspiratory Muscle Training.

    Hellyer, Nathan J; Folsom, Ian A; Gaz, Dan V; Kakuk, Alynn C; Mack, Jessica L; Ver Mulm, Jacyln A

    2015-12-01

    Inspiratory muscle training (IMT) strengthens the muscles of respiration, improves breathing efficiency, and increases fitness. The IMT is generally performed independently of aerobic exercise; however, it is not clear whether there is added benefit of performing the IMT while simultaneously performing aerobic exercise in terms of activating and strengthening inspiratory muscles. The purpose of our study was to determine the effect of IMT on respiratory muscle electromyography (EMG) activity during stationary cycling in the upright and drops postures as compared with that when the IMT was performed alone. Diaphragm and sternocleidomastoid EMG activity was measured under different resting and cycling postures, with and without the use of the IMT at 40% maximal inspiratory pressure (n = 10; mean age 37). Cycling in an upright posture while simultaneously performing the IMT resulted in a significantly greater diaphragm EMG activity than while performing the IMT at rest in upright or drops postures (p ≤ 0.05). Cycling in drops postures while performing the IMT had a significantly greater diaphragm EMG activity than when performing the IMT at rest in either upright or drops postures (p ≤ 0.05). Sternocleidomastoid muscle activity increased with both cycling and IMT, although posture had little effect. These results support our hypothesis in that the IMT while cycling increases respiratory EMG activity to a significantly greater extent than when performing the IMT solely at rest, suggesting that the combination of IMT and cycling may provide an additive training effect. PMID:26584054

  12. Cycling for Students with ASD: Self-Regulation Promotes Sustained Physical Activity

    Todd, Teri; Reid, Greg; Butler-Kisber, Lynn

    2010-01-01

    Individuals with autism often lack motivation to engage in sustained physical activity. Three adolescents with severe autism participated in a 16-week program and each regularly completed 30 min of cycling at the end of program. This study investigated the effect of a self-regulation instructional strategy on sustained cycling, which included…

  13. Observation of Hysteresis between Solar Activity Indicators and -mode Frequency Shifts for Solar Cycle 22

    S. C. Tripathy; Brajesh Kumar; Kiran Jain; A. Bhatnagar

    2000-09-01

    Using intermediate degree p-mode frequency data sets for solar cycle 22, we find that the frequency shifts and magnetic activity indicators show a ``hysteresis" phenomenon. It is observed that the magnetic indices follow different paths for the ascending and descending phases of the solar cycle while for radiative indices, the separation between the paths are well within the error limits.

  14. Quantification of Underestimation of Physical Activity During Cycling to School When Using Accelerometry

    Tarp, Jakob; Andersen, Lars B; Østergaard, Lars

    2015-01-01

    . Methods: Participants were 20 children aged 11-14 years from a randomized controlled trial performed in 2011. Physical activity was assessed by accelerometry with the addition of heart rate monitoring during cycling to school. Global positioning system (GPS) was used to identify periods of cycling to...... increased estimates of MVPA/day by 6.0 (95%CI: 3.8 - 9.6) minutes. Conclusions: Cycling to and from school contribute substantially to levels of MVPA and to mean counts/min in children. This was not collected by accelerometers. Using distance to school in conjunction with self-reported cycling to school may...

  15. Can origin of the 2400-year cycle of solar activity be caused by solar inertial motion?

    I. Charvátová

    2000-01-01

    A solar activity cycle of about 2400 years has until now been of uncertain origin. Recent results indicate it is caused by solar inertial motion. First we describe the 178.7-year basic cycle of solar motion. The longer cycle, over an 8000 year interval, is found to average 2402.2 years. This corresponds to the Jupiter/Heliocentre/Barycentre alignments (9.8855 × 243). Within each cycle an exceptional segment of 370 years has been found characterized by a looping pattern by a trefoil or quasitr...

  16. The Relationship between Plasma Antioxidant Enzymes Activity and Sex Hormones during the Menstrual Cycle

    Tavilani, H. (PhD

    2014-05-01

    Full Text Available Background and Objective: There is increasing evidence for the role of oxidative stress in female reproductive tract. The purpose of this study was to determine the activity of antioxidant enzymes during menstrual cycle. In addition, the relationship between activity of antioxidant enzyme and sex hormones was evaluated. Material and Methods: In this study the activity of superoxide dismutase, glutathione peroxidase, glutathione reductase, catalase and total antioxidant capacity during the menses, follicular and luteal phases of the menstrual cycle in twenty women with regular menstrual cycle were studied. Furthermore, the correlation between activity of antioxidant enzymes and estradiol, progesterone, LH, FSH and testosterone were evaluated. Results: There was no significant difference between activity of superoxide dismutase, glutathione peroxidase, glutathione reductase, catalase and total antioxidant capacity during the menses, follicular and luteal phases of the menstrual cycle (P>0.05. We found significant correlation, in luteal phase, between superoxide dismutase and FSH (P<0.05، r=0.44 and LH P<0.05،r=0.54. Also it is observed between LH and glutathione peroxidase (P<0.05، r=0.44. Conclusion: Based on the results, there is no significant difference between antioxidant enzymes and total antioxidant capacity of plasma during menstrual cycle. In other words, physiologic system of women with regular menstrual cycle can protect body against oxidative stress and this is probably performed due to action of FSH and LH hormones. Keywords: Antioxidants; Menstrual cycle; Sex hormones

  17. Diurnal cycles in serotonin acetyltransferase activity and cyclic GMP content of cultured chick pineal glands.

    Wainwright, S D

    1980-06-12

    Levels of serotonin N-acetyltransferase (NAT: acetul CoA:arylamine N-acetyltransferase; EC 2.1.1.5.) activity in the chick pineal gland exhibit a marked diurnal variation in birds kept under a diurnal cycle of ilumination. Activity begins to rise rapidly at the start of the dark phase of the cycle and reaches maximum levels at mid-dark phase about 25-fold greater than the minimum basal level at mid-light phase. Thereafter, the level of activity declines to the basal level about the start of the light phase. This diurnal cycle in chick pineal NAT activity found in vivo has recently been reproduced in vitro with intact glands incubated in organ culture. The mechanism of the 'biological clock' which regulates these variations in level of chick pineal NAT activity is unknown. However, I now report that chick pineal glands cultured under a diurnal cycle of illumination exhibit a diurnal cycle in content of cyclic GMP which roughly parallels the cycles in NAT activity. In contrast, there was no correlation between variations in pineal content of cyclic AMP and in level of NAT activity. PMID:6250035

  18. North-south asymmetry of solar dynamo in the current activity cycle

    Kitchatinov, L L

    2014-01-01

    An explanation is suggested for the north-south asymmetry of the polar magnetic field reversal in the current cycle of solar activity. The contribution of the Babcock-Leighton mechanism to the poloidal field generation is estimated using sunspot data for the current activity cycle. Estimations are performed separately for the northern and southern hemispheres. The contribution of the northern hemisphere exceeded considerably that of the southern hemisphere during the initial stage of the cycle. This is the probable reason for the earlier reversal of the northern polar field. The estimated contributions of the Babcock-Leighton mechanism are considerably smaller than similar estimations for the previous activity cycles. A relatively weak (<1G) large-scale polar field can be expected for the next activity minimum.

  19. Menstrual cycle elicits divergent forearm vascular responses to vestibular activation in humans

    Lawrence, Johnathan E.; Klein, Jenna C.; Carter, Jason R.

    2009-01-01

    The menstrual cycle has been reported to alter mean arterial pressure (MAP), but not muscle sympathetic nerve activity (MSNA), during vestibular activation. Specifically, MAP responses to head-down rotation (HDR) are augmented during the midluteal (ML) phase compared to the early follicular (EF) phase in young, eumenorrheic women. The purpose of the present study was to determine if the menstrual cycle influences vestibular-mediated changes in limb blood flow. MSNA, MAP, heart rate, and limb ...

  20. Separations in back-end of nuclear fuel cycle: overview of R and D activities

    This article discusses various areas in back-end of nuclear fuel cycle where R and D activities in separation science are actively pursued. Solvent extraction and ion-exchange are the main techniques where maximum developmental activities are underway. In addition to actual techniques, article also discusses the status of the studies especially where the process has been applied on larger scale. (author)

  1. Long-term variations in the geomagnetic activity level Part II: Ascending phases of sunspot cycles

    H. Nevanlinna

    Full Text Available Monthly averages of the Helsinki Ak-values have been reduced to the equivalent aa-indices to extend the aa-data set back to 1844. A periodicity of about five cycles was found for the correlation coefficient (r between geomagnetic indices and sunspot numbers for the ascending phases of sunspot cycles 9 to 22, confirming previous findings based on a minor number of sunspot cycles. The result is useful to researchers in topics related to solar-terrestrial physics, particularly for the interpretation of long-term trends in geomagnetic activity during the past, and to forecast geomagnetic activity levels in the future.

  2. iota Horologi, the first coronal activity cycle in a young solar-like star

    Sanz-Forcada, J; Metcalfe, T S; 10.1051/0004-6361/201321388

    2013-01-01

    Context: The shortest chromospheric (Ca II H&K) activity cycle (1.6 yr) has been recently discovered in the young (~600 Myr) solar-like star iota Hor. Coronal X-ray activity cycles have only been discovered in a few stars other than the Sun, all of them with an older age and a lower activity level than iota Hor. Aims: We intended to find the X-ray coronal counterpart of the chromospheric cycle for i Hor. This represents the first X-ray cycle observed in an active star, as well as the paradigm of the first coronal cycles in the life of a solar-like star. Methods: We monitored i Hor with XMM-Newton observations spanning almost two years. The spectra of each observation are fit with two-temperature coronal models to study the long-term variability of the star. Results: We find a cyclic behavior in X-rays very similar to the contemporaneous chromospheric cycle. The continuous chromospheric monitoring for more than three cycle lengths shows a trend toward decreasing amplitude, apparently modulated by a longer ...

  3. Viral activities and life cycles in deep subseafloor sediments.

    Engelhardt, Tim; Orsi, William D; Jørgensen, Bo Barker

    2015-12-01

    Viruses are highly abundant in marine subsurface sediments and can even exceed the number of prokaryotes. However, their activity and quantitative impact on microbial populations are still poorly understood. Here, we use gene expression data from published continental margin subseafloor metatranscriptomes to qualitatively assess viral diversity and activity in sediments up to 159 metres below seafloor (mbsf). Mining of the metatranscriptomic data revealed 4651 representative viral homologues (RVHs), representing 2.2% of all metatranscriptome sequence reads, which have close translated homology (average 77%, range 60-97% amino acid identity) to viral proteins. Archaea-infecting RVHs are exclusively detected in the upper 30 mbsf, whereas RVHs for filamentous inoviruses predominate in the deepest sediment layers. RVHs indicative of lysogenic phage-host interactions and lytic activity, notably cell lysis, are detected at all analysed depths and suggest a dynamic virus-host association in the marine deep biosphere studied here. Ongoing lytic viral activity is further indicated by the expression of clustered, regularly interspaced, short palindromic repeat-associated cascade genes involved in cellular defence against viral attacks. The data indicate the activity of viruses in subsurface sediment of the Peruvian margin and suggest that viruses indeed cause cell mortality and may play an important role in the turnover of subseafloor microbial biomass. PMID:26109514

  4. Wastes from selected activities in two light-water reactor fuel cycles

    This report presents projected volumes and radioactivities of wastes from the production of electrical energy using light-water reactors (LWR). The projections are based upon data developed for a recent environmental impact statement in which the transuranic wastes (i.e., those wastes containing certain long-lived alpha emitters at concentrations of at least 370 becquerels, or 10 nCi, per gram of waste) from fuel cycle activities were characterized. In addition, since the WG.7 assumed that all fuel cycle wastes except mill tailings are placed in a mined geologic repository, the nontransuranic wastes from several activities are included in the projections reported. The LWR fuel cycles considered are the LWR, once-through fuel cycle (Strategy 1), in which spent fuel is packaged in metal canisters and then isolated in geologic formations; and the LWR U/Pu recycle fuel cycle (Strategy 2), wherein spent fuel is reprocessed for recovery and recycle of uranium and plutonium in LWRs. The wastes projected for the two LWR fuel cycles are summarized. The reactor operations and decommissioning were found to dominate the rate of waste generation in each cycle. These activities account for at least 85% of the fuel cycle waste volume (not including head-end wastes) when normalized to per unit electrical energy generated. At 10 years out of reactor, however, spent fuel elements in Strategy 1 represent 98% of the fuel cycle activity but only 4% of the volume. Similarly, the packaged high-level waste, fuel hulls and hardware in Strategy 2 concentrate greater than 95% of the activity in 2% of the waste volume

  5. Microbial Enzyme Activity and Carbon Cycling in Grassland Soil Fractions

    Allison, S. D.; Jastrow, J. D.

    2004-12-01

    Extracellular enzymes are necessary to degrade complex organic compounds present in soils. Using physical fractionation procedures, we tested whether old soil carbon is spatially isolated from degradative enzymes across a prairie restoration chronosequence in Illinois, USA. We found that carbon-degrading enzymes were abundant in all soil fractions, including macroaggregates, microaggregates, and the clay fraction, which contains carbon with a mean residence time of ~200 years. The activities of two cellulose-degrading enzymes and a chitin-degrading enzyme were 2-10 times greater in organic matter fractions than in bulk soil, consistent with the rapid turnover of these fractions. Polyphenol oxidase activity was 3 times greater in the clay fraction than in the bulk soil, despite very slow carbon turnover in this fraction. Changes in enzyme activity across the restoration chronosequence were small once adjusted for increases in soil carbon concentration, although polyphenol oxidase activity per unit carbon declined by 50% in native prairie versus cultivated soil. These results are consistent with a `two-pool' model of enzyme and carbon turnover in grassland soils. In light organic matter fractions, enzyme production and carbon turnover both occur rapidly. However, in mineral-dominated fractions, both enzymes and their carbon substrates are immobilized on mineral surfaces, leading to slow turnover. Soil carbon accumulation in the clay fraction and across the prairie restoration chronosequence probably reflects increasing physical isolation of enzymes and substrates on the molecular scale, rather than the micron to millimeter scale.

  6. Looking for activity cycles in late-type Kepler stars using time-frequency analysis

    Vida, K; Szabó, R

    2014-01-01

    We analyse light curves covering four years of 39 fast-rotating ($P_\\mathrm{rot}< 1d$) late-type active stars from the Kepler database. Using time-frequency analysis (Short-Term Fourier-Transform), we find hints for activity cycles of 300-900 days at 9 targets from the changing typical latitude of the starspots, which, with the differential rotation of the stellar surface change the observed rotation period over the activity cycle. We also give a lowest estimation for the shear parameter of the differential rotation, which is ~0.001 for the cycling targets. These results populate the less studied, short period end of the rotation-cycle length relation.

  7. Do Male And Female Cyclists' Cortical Activity Differ Before and During Cycling Exercise?

    Ludyga, Sebastian; Gronwald, Thomas; Hottenrott, Kuno

    2015-12-01

    Although men and women are suggested to vary in resistance to fatigue, possible sex difference in its central component have rarely been investigated via electroencephalography (EEG). Therefore, we examined differences in cortical activity between male and female cyclists (n = 26) during cycling exercise. Participants performed an incremental test to derive the anaerobic threshold from the lactate power curve. In addition, cyclists' cortical activity was recorded with EEG before and during cycling exercise. Whereas women showed higher frontal alpha and beta activity at rest, no sex-specific differences of relative EEG spectral power occurred during cycling at higher intensity. Women and men's brains respond similarly during submaximal cycling, as both sexes show an inverted U-shaped curve of alpha power. Therefore, sex differences observable at rest vanish after the onset of exercise. PMID:26866769

  8. Unusual migration of the prominence activities in the southern hemisphere during Cycle 23--24

    Shimojo, Masumi

    2013-01-01

    The solar activity in Cycle 23--24 shows differences from the previous cycles that were observed with modern instruments, e.g. long cycle duration and a small number of sunspots. To appreciate the anomalies further, we investigated the prominence eruptions and disappearances observed with the Nobeyama Radioheliograph during over 20 years. Consequently, we found that the occurrence of the prominence activities in the northern hemisphere is normal because the period of the number variation is 11 years and the migration of the producing region of the prominence activities traces the migration of 11 years ago. On the other hand, the migration in the southern hemisphere significantly differs from that in the northern hemisphere and the previous cycles. The prominence activities occurred over -50 degrees latitude in spite of the late decay phase of Cycle 23, and the number of the prominence activities in the higher latitude region (over -65 degrees) is very small even near the solar maximum of Cycle 24. The results...

  9. Common 22-year cycles of Earth rotation and solar activity

    Chapanov, Y.; Vondrák, Jan; Ron, Cyril

    Cambridge: Cambridge University Press, 2010 - (Kosovichev, A.; Andrei, A.; Rozelot, J.), s. 404-406. (IAU Symposium Proceedings Series. S264). ISBN 978-0-521-76492-6. ISSN 1743-9213. [Symposium of the International Astronomical Union /264./. Rio de Janeiro (BR), 03.08.2009-07.08.2009] Institutional research plan: CEZ:AV0Z10030501 Keywords : Sun activity * sunspots * solar-terrestrial relations Subject RIV: AC - Archeology, Anthropology, Ethnology

  10. Intertwined arbovirus transmission activity: reassessing the transmission cycle paradigm.

    LuisAdrianDiaz

    2013-01-01

    Arboviruses are emerging/reemerging infectious agents worldwide. The factors within this scenario include vector and host population fluctuations, climatic changes, anthropogenic activities that disturb ecosystems, an increase in international flights, human mobility, and genetic mutations that allow spill-over phenomenon. Arboviruses are maintained by biologic transmission among vectors and hosts. Sometimes this biological transmission is specific and includes one vector and host species suc...

  11. Frowning and Jaw Clenching Muscle Activity Reflects the Perception of Effort During Incremental Workload Cycling

    Ding-Hau Huang, Shih-Wei Chou, Yi-Lang Chen, Wen-Ko Chiou

    2014-12-01

    Full Text Available The present study aimed to investigate whether facial electromyography (EMG recordings reflect the perception of effort and primary active lower limb muscle activity during incremental workload cycling. The effects of exercise intensity on EMG activity of the corrugator supercilii (CS, masseter and vastus lateralis (VL muscles, heart rate (HR and the rating of perceived exertion (RPE were investigated, and the correlations among these parameters were determined. Eighteen males and 15 females performed continuous incremental workload cycling exercise until exhaustion. CS, masseter and VL muscle activities were continuously recorded using EMG during exercise. HR was also continuously monitored during the test. During the final 30 s of each stage of cycle ergometer exercise, participants were asked to report their feeling of exertion on the adult OMNI-Cycle RPE. HR and EMG activity of the facial muscles and the primary active lower limb muscle were strongly correlated with RPE; they increased with power output. Furthermore, facial muscle activity increased significantly during high-intensity exercise. Masseter muscle activity was strongly and positively correlated with HR, RPE and VL activity. The present investigation supports the view that facial EMG activity reflects the perception of effort. The jaw clenching facial expression can be considered an important factor for improving the reporting of perceived effort during high-intensity exercise in males and females.

  12. The activity cycle of 67P/Churyumov-Gerasimenko

    Snodgrass, C.; Barrera, L.; Boehnhardt, H.; Guilbert-Lepoutre, A.; Hainaut, O.; Hutsemékers, D.; Jehin, E.; Meech, K.; Opitom, C.; Schulz, R.; Tozzi, G.; Tubiana, C.

    2014-07-01

    We present ground-based observations of comet 67P/Churyumov-Gerasimenko, target of the Rosetta mission, and an assessment on its activity levels. Based on imaging in the R-band, we measure the brightness of the coma within various apertures and use this to assess the amount of dust in the coma. We find that the comet begins to show detectable activity at a pre-perihelion distance from the Sun of 4.3 au, and then shows a smooth increase in production to a peak around one month after perihelion passage. The behaviour of the comet is consistent from one orbit to another, based on archival images taken over three apparitions, and we therefore use the heliocentric lightcurve to make predictions for the 2014/5 period while Rosetta is operating at the comet. We find that the Afρ parameter, measured within an aperture of radius 10,000 km at the comet, is proportional to r^{-3.2}, pre-perihelion [1]. We also attempt to make predictions on the gas production rate by fitting a model to the observed brightness values. This is done by assuming various parameters about the nucleus and dust, many of which are reasonably well constrained for 67P, and solving an energy balance equation that gives the sublimation rate of various ices as a function of solar illumination [2]. The model then links the gas production rate to the total amount of dust in the coma, and its brightness. We find that only a small fraction of the surface area (1.4 %) needs to be active for water sublimation, with an extra peak (up to 4 %) for a month either side of perihelion, while an even smaller area is producing CO_2 (0.04-0.09 %) [1]. The predictions can now be tested against new observations, and we will present the latest results from our 2014 monitoring of 67P. We are performing regular R-band imaging on the comet using the VLT, and early indications in March 2014 indicate that the comet does appear to have returned to activity as expected. By the time of the ACM meeting we will have around 4 months

  13. On the existence of the 11-year cycle in solar activity before the Maunder minimum

    The existence of the 11-year cycle in solar activity before the Maunder minimum is clearly demonstrated with cosmogenic 10Be in polar ice during 1180--1500 A.D. For that interval a periodicity of 11.4 +- 0.2 years is found with a high significance level. Indication of a cyclicity that resembles the Hale magnetic cycle is also observed at a lower significance level. A highly variable cyclicity in the band 9.5--11.5 years is also found in the record of historical aurorae which appears to be well correlated with the 10Be cyclicity for the same time interval. It is concluded that the Schwabe, or 11-year, cycle and the Hale magnetic cycle were present before and after the Maunder minimum, even though it is not possible to understand the variability of the cycle. copyright American Geophysical Union 1988

  14. Active vibration and balance system for closed cycle thermodynamic machines

    Qiu, Songgang (Inventor); Augenblick, John E. (Inventor); Peterson, Allen A. (Inventor); White, Maurice A. (Inventor)

    2004-01-01

    An active balance system is provided for counterbalancing vibrations of an axially reciprocating machine. The balance system includes a support member, a flexure assembly, a counterbalance mass, and a linear motor or an actuator. The support member is configured for attachment to the machine. The flexure assembly includes at least one flat spring having connections along a central portion and an outer peripheral portion. One of the central portion and the outer peripheral portion is fixedly mounted to the support member. The counterbalance mass is fixedly carried by the flexure assembly along another of the central portion and the outer peripheral portion. The linear motor has one of a stator and a mover fixedly mounted to the support member and another of the stator and the mover fixedly mounted to the counterbalance mass. The linear motor is operative to axially reciprocate the counterbalance mass. A method is also provided.

  15. TGEV nucleocapsid protein induces cell cycle arrest and apoptosis through activation of p53 signaling

    Ding, Li [College of Veterinary Medicine, Northwest A and F University, Yangling, Shaanxi 712100 (China); College of Life Sciences, Hainan Normal University, Haikou, Hainan 571158 (China); Huang, Yong; Du, Qian; Dong, Feng; Zhao, Xiaomin; Zhang, Wenlong; Xu, Xingang [College of Veterinary Medicine, Northwest A and F University, Yangling, Shaanxi 712100 (China); Tong, Dewen, E-mail: dwtong@nwsuaf.edu.cn [College of Veterinary Medicine, Northwest A and F University, Yangling, Shaanxi 712100 (China)

    2014-03-07

    Highlights: • TGEV N protein reduces cell viability by inducing cell cycle arrest and apoptosis. • TGEV N protein induces cell cycle arrest and apoptosis by regulating p53 signaling. • TGEV N protein plays important roles in TGEV-induced cell cycle arrest and apoptosis. - Abstract: Our previous studies showed that TGEV infection could induce cell cycle arrest and apoptosis via activation of p53 signaling in cultured host cells. However, it is unclear which viral gene causes these effects. In this study, we investigated the effects of TGEV nucleocapsid (N) protein on PK-15 cells. We found that TGEV N protein suppressed cell proliferation by causing cell cycle arrest at the S and G2/M phases and apoptosis. Characterization of various cellular proteins that are involved in regulating cell cycle progression demonstrated that the expression of N gene resulted in an accumulation of p53 and p21, which suppressed cyclin B1, cdc2 and cdk2 expression. Moreover, the expression of TGEV N gene promoted translocation of Bax to mitochondria, which in turn caused the release of cytochrome c, followed by activation of caspase-3, resulting in cell apoptosis in the transfected PK-15 cells following cell cycle arrest. Further studies showed that p53 inhibitor attenuated TGEV N protein induced cell cycle arrest at S and G2/M phases and apoptosis through reversing the expression changes of cdc2, cdk2 and cyclin B1 and the translocation changes of Bax and cytochrome c induced by TGEV N protein. Taken together, these results demonstrated that TGEV N protein might play an important role in TGEV infection-induced p53 activation and cell cycle arrest at the S and G2/M phases and apoptosis occurrence.

  16. OECD/NEA Ongoing activities related to the nuclear fuel cycle

    As part of its role in encouraging international collaboration, the OECD Nuclear Energy Agency is coordinating a series of projects related to the Nuclear Fuel Cycle. The Nuclear Science Committee (NSC) Working Party on Scientific Issues of the Nuclear Fuel Cycle (WPFC) comprises five different expert groups covering all aspects of the fuel cycle from front to back-end. Activities related to fuels, materials, physics, separation chemistry, and fuel cycles scenarios are being undertaken. By publishing state-of-the-art reports and organizing workshops, the groups are able to disseminate recent research advancements to the international community. Current activities mainly focus on advanced nuclear systems, and experts are working on analyzing results and establishing challenges associated to the adoption of new materials and fuels. By comparing different codes, the Expert Group on Advanced Fuel Cycle Scenarios is aiming at gaining further understanding of the scientific issues and specific national needs associated with the implementation of advanced fuel cycles. At the back end of the fuel cycle, separation technologies (aqueous and pyrochemical processing) are being assessed. Current and future activities comprise studies on minor actinides separation and post Fukushima studies. Regular workshops are also organized to discuss recent developments on Partitioning and Transmutation. In addition, the Nuclear Development Committee (NDC) focuses on the analysis of the economics of nuclear power across the fuel cycle in the context of changes of electricity markets, social acceptance and technological advances and assesses the availability of the nuclear fuel and infrastructure required for the deployment of existing and future nuclear power. The Expert Group on the Economics of the Back End of the Nuclear Fuel Cycle (EBENFC), in particular, is looking at assessing economic and financial issues related to the long term management of spent nuclear fuel. (authors)

  17. IAEA activities in the area of thorium based nuclear fuel cycles

    In the framework of IAEA activities Implementing Thorium in Nuclear Fuel Cycles is one of the challenging topics. Incentives for Th-based fuel cycles (vs. U-Pu cycles) are: 233-U breeding capability due to its higher neutron yields in thermal and epithermal regions in Th-233-U cycle; Large Th deposits in some countries; Potentials for fuel cycle cost reduction, 235-U enrichment reduction, safer reactor operation due to lower excess reactivity requirements, safer and more reliable ThO2 fuel at high burnup, potential benefits for reducing Pu production and higher actinides. Disadvantages for Th-based fuel cycles (vs. U-Pu cycles) are: More difficult fuel handling due to its stronger gamma radiation level (228-Tl: strong gamma emitter) - preferable for nonproliferation, more complicated fuel cycle mechanism, longer spent fuel cooling due to higher residual heat, potential difficulties in down stream spent fuel reprocessing. 'New' potential benefits for reducing Pu production and higher actinides are emerging. Coordinated Research Projects (CRPs) 'Potential of Thorium Based Fuel Cycles to Constrain Plutonium and to Reduce Long Lived Waste Toxicity' and 'Use of Thorium Based Fuel Cycles in Accelerator Driven Systems to Incinerate Plutonium and to Reduce Long-term Waste Toxicities' were completed. The following were published: assessment of thermo physical and thermo- hydraulic characteristics of lead, lead-bismuth, and sodium coolants for fast reactors (IAEA TECDOC-1289); Thorium fuel utilization: Options and trends (IAEA TECDOC-1319); Power Reactor and Sub-critical Blanket Systems with Lead and Lead-Bismuth as Coolant and/or Target Material (IAEA TECDOC-1348) Potential of thorium based fuel cycles to constrain plutonium and reduce long lived waste toxicity (IAEA TECDOC-1349). 35th and 36th TWG-FR Meetings recommended to convene a Consultancy to recommend topics for a CRP at investigating the potential benefits of Thorium fuels

  18. Can origin of the 2400-year cycle of solar activity be caused by solar inertial motion?

    I. Charvátová

    Full Text Available A solar activity cycle of about 2400 years has until now been of uncertain origin. Recent results indicate it is caused by solar inertial motion. First we describe the 178.7-year basic cycle of solar motion. The longer cycle, over an 8000 year interval, is found to average 2402.2 years. This corresponds to the Jupiter/Heliocentre/Barycentre alignments (9.8855 × 243. Within each cycle an exceptional segment of 370 years has been found characterized by a looping pattern by a trefoil or quasitrefoil geometry. Solar activity, evidenced by 14C tree-ring proxies, shows the same pattern. Solar motion is computable in advance, so this provides a basis for future predictive assessments. The next 370-year segment will occur between AD 2240 and 2610.

    Key words: Solar physics (celestial mechanics

  19. Looking for activity cycles in late-type Kepler stars using time-frequency analysis

    Vida, K.; Oláh, K.; Szabó, R.

    2014-01-01

    We analyse light curves covering four years of 39 fast-rotating ($P_\\mathrm{rot}< 1d$) late-type active stars from the Kepler database. Using time-frequency analysis (Short-Term Fourier-Transform), we find hints for activity cycles of 300-900 days at 9 targets from the changing typical latitude of the starspots, which, with the differential rotation of the stellar surface change the observed rotation period over the activity cycle. We also give a lowest estimation for the shear parameter of t...

  20. A viral gene that activates lytic cycle expression of Kaposi’s sarcoma-associated herpesvirus

    Sun, Ren; Lin, Su-Fang; Gradoville, Lyndle; YUAN, YAN; Zhu, Fanxiu; Miller, George

    1998-01-01

    Herpesviruses exist in two states, latency and a lytic productive cycle. Here we identify an immediate-early gene encoded by Kaposi’s sarcoma-associated herpesvirus (KSHV)/human herpesvirus eight (HHV8) that activates lytic cycle gene expression from the latent viral genome. The gene is a homologue of Rta, a transcriptional activator encoded by Epstein–Barr virus (EBV). KSHV/Rta activated KSHV early lytic genes, including virus-encoded interleukin 6 and polyadenylated nuclear RNA, and a late ...

  1. High duty cycle operation of quantum cascade lasers based on graded superlattice active regions

    High duty cycle operation of quantum cascade superlattice lasers with graded superlattice active regions is investigated with the goal of achieving high average optical power. The optical output power increases with pulse width and decreases with heat sink temperature. This behavior is explained on the basis of the laser core temperature oscillations during the pulsed, high duty cycle operation. Between 175 and 325 K heat sink temperature, optimum duty cycles vary from 10% to 1% and average power levels vary from 50 to 1 mW for various lasers used in this study. [copyright] 2001 American Institute of Physics

  2. Electrically assisted cycling: A new mode for meeting physical activity guidelines?

    Simons, M.; Es, E. van; Hendriksen, I.

    2009-01-01

    PURPOSE: The purpose of this study was to assess the potential of the electrically assisted bicycle (EAB) as a novel tool for meeting the physical activity guidelines in terms of intensity. METHODS: Twelve habitually active adult subjects were requested to cycle a track of 4.3 km at an intensity the

  3. Proteomic and activity profiles of ascorbate-glutathione cycle enzymes in germinating barley embryo

    Bønsager, Birgit Christine; Shahpiri, Azar; Finnie, Christine;

    2010-01-01

    Enzymes involved in redox control are important during seed germination and seedling growth. Ascorbate-glutathione cycle enzymes in barley embryo extracts were monitored both by 2D-gel electrophoresis and activity measurements from 4 to 144 h post imbibition (PI). Strikingly different activity...

  4. Daytime spikes in dopaminergic activity drive rapid mood-cycling in mice

    Sidor, Michelle M.; Spencer, Sade M.; Dzirasa, Kafui; Parekh, Puja K.; Tye, Kay M; Warden, Melissa R.; Arey, Rachel N.; Enwright, John F; Jacobsen, Jacob PR; Kumar, Sunil; Remillard, Erin M; Marc G Caron; Deisseroth, Karl; McClung, Colleen A.

    2014-01-01

    Disruptions in circadian rhythms and dopaminergic activity are involved in the pathophysiology of bipolar disorder, though their interaction remains unclear. Moreover, a lack of animal models that display spontaneous cycling between mood states has hindered our mechanistic understanding of mood switching. Here we find that mice with a mutation in the circadian Clock gene (ClockΔ19) exhibit rapid mood-cycling, with a profound manic-like phenotype emerging during the day following a period of e...

  5. Discovery of an activity cycle in the solar analog HD 45184. Exploring Balmer and metallic lines as activity proxy candidates

    Flores, M.; González, J. F.; Jaque Arancibia, M.; Buccino, A.; Saffe, C.

    2016-05-01

    Context. Most stellar activity cycles similar to that found in the Sun have been detected by using the chromospheric Ca ii H&K lines as stellar activity proxies. However, it is unclear whether such activity cycles can be identified using other optical lines. Aims: We aim to detect activity cycles in solar-analog stars and determine whether they can be identified through other optical lines, such as Fe II and Balmer lines. We study the solar-analog star HD 45184 using HARPS spectra. The temporal coverage and high quality of the spectra allow us to detect both long- and short-term activity variations. Methods: We analysed the activity signatures of HD 45184 by using 291 HARPS spectra obtained between 2003 and 2014. To search for line-core flux variations, we focused on Ca ii H&K and Balmer Hα and Hβ lines, which are typically used as optical chromospheric activity indicators. We calculated the HARPS-S index from Ca ii H&K lines and converted it into the Mount Wilson scale. In addition, we also considered the equivalent widths of Balmer lines as activity indicators. Moreover, we analysed the possible variability of Fe ii and other metallic lines in the optical spectra. The spectral variations were analysed for periodicity using the Lomb-Scargle periodogram. Results: We report for the first time a long-term 5.14-yr activity cycle in the solar-analog star HD 45184 derived from Mount Wilson S index. This makes HD 45184 one of most similar stars to the Sun with a known activity cycle. The variation is also evident in the first lines of the Balmer series, which do not always show a correlation with activity in solar-type stars. Notably, unlike the solar case, we also found that the equivalent widths of the high photospheric Fe ii lines (4924 Å, 5018 Å and 5169 Å) are modulated (±2 mÅ) by the chromospheric cycle of the star. These metallic lines show variations above 4σ in the rms spectrum, while some Ba ii and Ti ii lines present variations at 3σ level, which

  6. Experimental study on solar-powered adsorption refrigeration cycle with activated alumina and activated carbon as adsorbent

    Himsar Ambarita

    2016-03-01

    Full Text Available Typical adsorbent applied in solar-powered adsorption refrigeration cycle is activated carbon. It is known that activated alumina shows a higher adsorption capacity when it is tested in the laboratory using a constant radiation heat flux. In this study, solar-powered adsorption refrigeration cycle with generator filled by different adsorbents has been tested by exposing to solar radiation in Medan city of Indonesia. The generator is heated using a flat-plate type solar collector with a dimension of 0.5 m×0.5 m. Four cases experiments of solar-powered adsorption cycle were carried out, they are with generator filled by 100% activated alumina (named as 100AA, by a mixed of 75% activated alumina and 25% activated carbon (75AA, by a mixed of 25% activated alumina and 75% activated carbon (25AA, and filled by 100% activated carbon. Each case was tested for three days. The temperature and pressure history and the performance have been presented and analyzed. The results show that the average COP of 100AA, 75AA, 25AA, and 100AC is 0.054, 0.056, 0.06, and 0.074, respectively. The main conclusion can be drawn is that for Indonesian condition and flat-plate type solar collector the pair of activated carbon and methanol is the better than activated alumina.

  7. Inferring yeast cell cycle regulators and interactions using transcription factor activities

    Galbraith Simon J

    2005-06-01

    Full Text Available Abstract Background Since transcription factors are often regulated at the post-transcriptional level, their activities, rather than expression levels may provide valuable information for investigating functions and their interactions. The recently developed Network Component Analysis (NCA and its generalized form (gNCA provide a robust framework for deducing the transcription factor activities (TFAs from various types of DNA microarray data and transcription factor-gene connectivity. The goal of this work is to demonstrate the utility of TFAs in inferring transcription factor functions and interactions in Saccharomyces cerevisiae cell cycle regulation. Results Using gNCA, we determined 74 TFAs from both wild type and fkh1 fkh2 deletion mutant microarray data encompassing 1529 ORFs. We hypothesized that transcription factors participating in the cell cycle regulation exhibit cyclic activity profiles. This hypothesis was supported by the TFA profiles of known cell cycle factors and was used as a basis to uncover other potential cell cycle factors. By combining the results from both cluster analysis and periodicity analysis, we recovered nearly 90% of the known cell cycle regulators, and identified 5 putative cell cycle-related transcription factors (Dal81, Hap2, Hir2, Mss11, and Rlm1. In addition, by analyzing expression data from transcription factor knockout strains, we determined 3 verified (Ace2, Ndd1, and Swi5 and 4 putative interaction partners (Cha4, Hap2, Fhl1, and Rts2 of the forkhead transcription factors. Sensitivity of TFAs to connectivity errors was determined to provide confidence level of these predictions. Conclusion By subjecting TFA profiles to analyses based upon physiological signatures we were able to identify cell cycle related transcription factors consistent with current literature, transcription factors with potential cell cycle dependent roles, and interactions between transcription factors.

  8. North South Asymmetry of Different Solar Activity Features During Solar Cycle 23

    Bankoti, Neeraj Singh; Pande, Seema; Pande, Bimal; Pandey, Kavita

    2009-01-01

    A study on North South (NS) asymmetry of different solar activity features (DSAF) such as solar proton events, solar active prominences, H alpha flare index, soft X ray flares, monthly mean sunspot area and monthly mean sunspot number were carried out from 1996 to 2008. It is found in our result that solar cycle 23 is magnetically weak compared to solar cycle 22. Study shows the Southern dominance of DSAF during the time period of study. During the rising phase of the cycle the numbers of DSAF approximately equal on the North and South Hemisphere. However, these activities tend to shift from Northern Hemisphere to Southern Hemisphere in between year 1998 to 1999. The statistical significance of the asymmetry time series using a chi square test of goodness of fit indicates that in most of the cases the asymmetry is highly significant, i.e., the asymmetry is a real feature in the NS distribution of DSAF.

  9. Transitions into and out of daylight saving time compromise sleep and the rest-activity cycles

    Lönnqvist Jouko

    2008-02-01

    Full Text Available Abstract Background The aim of this study was to analyze the effects of transition out of and into daylight saving time on the rest-activity cycles and sleep. Rest-activity cycles of nine healthy participants aged 20 to 40 years were measured around transitions out of and into daylight saving time on fall 2005 and spring 2006 respectively. Rest-activity cycles were measured using wrist-worn accelerometers. The participants filled in the Morningness-Eveningness and Seasonal Pattern Assessment Questionnaires before starting the study and kept a sleep diary during the study. Results Fall transition was more disturbing for the more morning type and spring transition for the more evening type of persons. Individuals having a higher global seasonality score suffered more from the transitions. Conclusion Transitions out of and into daylight saving time enhanced night-time restlessness and thereby compromised the quality of sleep.

  10. Neighborhood Walkability and Active Travel (Walking and Cycling) in New York City

    Freeman, Lance; Neckerman, Kathryn; Schwartz-Soicher, Ofira; Quinn, James; Richards, Catherine; Bader, Michael D. M.; Lovasi, Gina; Jack, Darby; Weiss, Christopher; Konty, Kevin; Arno, Peter; Viola, Deborah; Kerker, Bonnie; Rundle, Andrew G.

    2012-01-01

    Urban planners have suggested that built environment characteristics can support active travel (walking and cycling) and reduce sedentary behavior. This study assessed whether engagement in active travel is associated with neighborhood walkability measured for zip codes in New York City. Data were analyzed on engagement in active travel and the frequency of walking or biking ten blocks or more in the past month, from 8,064 respondents to the New York City 2003 Community Health Survey (CHS). A...

  11. Breathing of heliospheric structures triggered by the solar-cycle activity

    K. Scherer

    Full Text Available Solar wind ram pressure variations occuring within the solar activity cycle are communicated to the outer heliosphere as complicated time-variabilities, but repeating its typical form with the activity period of about 11 years. At outer heliospheric regions, the main surviving solar cycle feature is a periodic variation of the solar wind dynamical pressure or momentum flow, as clearly recognized by observations of the VOYAGER-1/2 space probes. This long-periodic variation of the solar wind dynamical pressure is modeled here through application of appropriately time-dependent inner boundary conditions within our multifluid code to describe the solar wind – interstellar medium interaction. As we can show, it takes several solar cycles until the heliospheric structures adapt to an average location about which they carry out a periodic breathing, however, lagged in phase with respect to the solar cycle. The dynamically active heliosphere behaves differently from a static heliosphere and especially shows a historic hysteresis in the sense that the shock structures move out to larger distances than explained by the average ram pressure. Obviously, additional energies are pumped into the heliosheath by means of density and pressure waves which are excited. These waves travel outwards through the interface from the termination shock towards the bow shock. Depending on longitude, the heliospheric sheath region memorizes 2–3 (upwind and up to 6–7 (downwind preceding solar activity cycles, i.e. the cycle-induced waves need corresponding travel times for the passage over the heliosheath. Within our multifluid code we also adequately describe the solar cycle variations in the energy distributions of anomalous and galactic cosmic rays, respectively. According to these results the distribution of these high energetic species cannot be correctly described on the basis of the actually prevailing solar wind conditions.

    Key words. Interplanetary

  12. Predictive Duty Cycle Control of Three-Phase Active-Front-End Rectifiers

    Song, Zhanfeng; Tian, Yanjun; Chen, Wei;

    2016-01-01

    This paper proposed an on-line optimizing duty cycle control approach for three-phase active-front-end rectifiers, aiming to obtain the optimal control actions under different operating conditions. Similar to finite control set model predictive control strategy, a cost function previously...... constructed based on the desired control performance is adopted here, which is essential for the solving process of the optimizing problem. On the other hand, differently, with respect to the proposed strategy, duty cycle signals are optimized, instead of possible switching states. The determination...... of optimal duty cycles is made by predicting the effect of duty cycles on instantaneous current variations and minimizing the cost function. Due to the adoption of behavior prediction, the proposed controller inherits the excellent dynamic characteristics of predictive controllers. Moreover, the application...

  13. SOLAR MAGNETIC ACTIVITY CYCLES, CORONAL POTENTIAL FIELD MODELS AND ERUPTION RATES

    Petrie, G. J. D. [National Solar Observatory, Tucson, AZ 85719 (United States)

    2013-05-10

    We study the evolution of the observed photospheric magnetic field and the modeled global coronal magnetic field during the past 3 1/2 solar activity cycles observed since the mid-1970s. We use synoptic magnetograms and extrapolated potential-field models based on longitudinal full-disk photospheric magnetograms from the National Solar Observatory's three magnetographs at Kitt Peak, the Synoptic Optical Long-term Investigations of the Sun vector spectro-magnetograph, the spectro-magnetograph and the 512-channel magnetograph instruments, and from Stanford University's Wilcox Solar Observatory. The associated multipole field components are used to study the dominant length scales and symmetries of the coronal field. Polar field changes are found to be well correlated with active fields over most of the period studied, except between 2003 and 2006 when the active fields did not produce significant polar field changes. Of the axisymmetric multipoles, only the dipole and octupole follow the poles whereas the higher orders follow the activity cycle. All non-axisymmetric multipole strengths are well correlated with the activity cycle. The tilt of the solar dipole is therefore almost entirely due to active-region fields. The axial dipole and octupole are the largest contributors to the global field except while the polar fields are reversing. This influence of the polar fields extends to modulating eruption rates. According to the Computer Aided CME Tracking, Solar Eruptive Event Detection System, and Nobeyama radioheliograph prominence eruption catalogs, the rate of solar eruptions is found to be systematically higher for active years between 2003 and 2012 than for those between 1997 and 2002. This behavior appears to be connected with the weakness of the late-cycle 23 polar fields as suggested by Luhmann. We see evidence that the process of cycle 24 field reversal is well advanced at both poles.

  14. The Development of a New Practical Activity: Using Microorganisms to Model Gas Cycling

    Redfern, James; Burdass, Dariel; Verran, Joanna

    2014-01-01

    For many in the school science classroom, the term "microbiology" has become synonymous with "bacteriology". By overlooking other microbes, teachers may miss out on powerful practical tools. This article describes the development of an activity that uses algae and yeast to demonstrate gas cycling, and presents full instructions…

  15. Geomagnetic activity during 10 - 11 solar cycles that has been observed by old Russian observatories.

    Seredyn, Tomasz; Wysokinski, Arkadiusz; Kobylinski, Zbigniew; Bialy, Jerzy

    2016-07-01

    A good knowledge of solar-terrestrial relations during past solar activity cycles could give the appropriate tools for a correct space weather forecast. The paper focuses on the analysis of the historical collections of the ground based magnetic observations and their operational indices from the period of two sunspot solar cycles 10 - 11, period 1856 - 1878 (Bartels rotations 324 - 635). We use hourly observations of H and D geomagnetic field components registered at Russian stations: St. Petersburg - Pavlovsk, Barnaul, Ekaterinburg, Nertshinsk, Sitka, and compare them to the data obtained from the Helsinki observatory. We compare directly these records and also calculated from the data of the every above mentioned station IHV indices introduced by Svalgaard (2003), which have been used for further comparisons in epochs of assumed different polarity of the heliospheric magnetic field. We used also local index C9 derived by Zosimovich (1981) from St. Petersburg - Pavlovsk data. Solar activity is represented by sunspot numbers. The correlative and continuous wavelet analyses are applied for estimation of the correctness of records from different magnetic stations. We have specially regard to magnetic storms in the investigated period and the special Carrington event of 1-2 Sep 1859. Generally studied magnetic time series correctly show variability of the geomagnetic activity. Geomagnetic activity presents some delay in relation to solar one as it is seen especially during descending and minimum phase of the even 11-year cycle. This pattern looks similarly in the case of 16 - 17 solar cycles.

  16. Effect of sprint cycle training on activities of antioxidant enzymes in human skeletal muscle

    Hellsten, Ylva; Apple, F. S.; Sjödin, B.

    1996-01-01

    (P < 0.05) elevation in the activity of phosphofructokinase and creatine kinase, implying an enhanced anaerobic capacity in the trained muscle. The present study demonstrates that intermittent sprint cycle training that induces an enhanced capacity for anaerobic energy generation also improves the...

  17. Functional activity of sphingomyelin cycle in rat liver in chronic toxic hepatitis.

    Serebrov, V Yu; Kuzmenko, D I; Burov, P G; Novitsky, S V

    2008-12-01

    Activities of sphingomyelinase and ceramidase decreased in the liver in chronic toxic hepatitis and the balance between the levels of proapoptotic ceramide and antiapoptotic sphyngosine-1-phosphate shifts towards the latter substance. Pronounced changes in the qualitative and quantitative composition of fatty acids in the sphingomyelin cycle effector molecules were revealed. PMID:19513367

  18. Passive and Active Restoration Strategies to Activate Soil Biogeochemical Nutrient Cycles in a Degraded Tropical Dry Land

    Restrepo, Manuel F.; Florez, Claudia P.; Osorio, Nelson W.; Juan D. León

    2013-01-01

    The potential use of two restoration strategies to activate biogeochemical nutrient cycles in degraded soils in Colombia was studied. The active model was represented by forest plantations of neem (Azadirachta indica) (FPN), while the passive model by successional patches of native plant species was dominated by mosquero (Croton leptostachyus) (SPM). In the field plots fine-litter traps and litter-bags were established; samples of standing litter and surface soil samples (0–10 cm) were collec...

  19. Physical activity, sleep duration and metabolic health in children fluctuate with the lunar cycle

    Sjödin, Anders Mikael; Hjorth, Mads Fiil; Damsgaard, Camilla Trab;

    2015-01-01

    glucose regulation and physical activity to improve glucose regulation, one could speculate that cardiometabolic risk factors might also be affected by the lunar phase. We retrospectively examined 795 Danish children, aged 8-11 years, with more than 13 000 24-h accelerometer recordings of activity and...... behaviour and the lunar cycle or confounders that may explain this, apparently leading to fluctuation in a number of cardiometabolic risk markers conjointly with lunar phases....

  20. Orbitofrontal cortex activity related to emotional processing changes across the menstrual cycle

    Protopopescu, Xenia; Pan, Hong; Altemus, Margaret; Tuescher, Oliver; Polanecsky, Margaret; McEwen, Bruce; Silbersweig, David; Stern, Emily

    2005-01-01

    The orbitofrontal cortex (OFC) has been implicated in the representation of emotional stimuli, assignment of emotional valence/salience to stimuli, stimulus-reinforcement association learning, motivation, and socio-emotional control. Using functional magnetic resonance imaging in female subjects without premenstrual mood symptoms, we found that OFC activity to emotional linguistic stimuli varies depending on the menstrual cycle phase. Specifically, anterior-medial OFC activity for negative vs...

  1. Ectopic Expression of an Activated RAC in Arabidopsis Disrupts Membrane CyclingD⃞V⃞

    Bloch, Daria; Lavy, Meirav; Efrat, Yael; Efroni, Idan; Bracha-Drori, Keren; Abu-Abied, Mohamad; Sadot, Einat; Yalovsky, Shaul

    2005-01-01

    Rho GTPases regulate the actin cytoskeleton, exocytosis, endocytosis, and other signaling cascades. Rhos are subdivided into four subfamilies designated Rho, Racs, Cdc42, and a plant-specific group designated RACs/Rops. This research demonstrates that ectopic expression of a constitutive active Arabidopsis RAC, AtRAC10, disrupts actin cytoskeleton organization and membrane cycling. We created transgenic plants expressing either wild-type or constitutive active AtRAC10 fused to the green fluor...

  2. The sunspot cycle no. 24 in relation to long term solar activity variation.

    Komitov, Boris; Kaftan, Vladimir

    2013-05-01

    The solar minimum between solar cycles 23 and 24 during the period 2007-2009 has been the longest and deepest one at least since for the last 100 years. We suggest that the Sun is going to his next supercenturial minimum. The main aim of this paper is to tell about arguments concerning this statement. They are based on series of studies, which have been provided during the period since 1997 up to 2010. The progress of solar cycle 24 since its minimum at the end of 2008 up to the end of October 2011 in the light of long term solar activity dynamics is analyzed. PMID:25685429

  3. The sunspot cycle no. 24 in relation to long term solar activity variation

    Boris Komitov

    2013-05-01

    Full Text Available The solar minimum between solar cycles 23 and 24 during the period 2007–2009 has been the longest and deepest one at least since for the last 100 years. We suggest that the Sun is going to his next supercenturial minimum. The main aim of this paper is to tell about arguments concerning this statement. They are based on series of studies, which have been provided during the period since 1997 up to 2010. The progress of solar cycle 24 since its minimum at the end of 2008 up to the end of October 2011 in the light of long term solar activity dynamics is analyzed.

  4. Study of Distribution and Asymmetry of Solar Active Prominences During Solar Cycle 23

    Joshi, Navin Chandra; Pande, Seema; Pande, Bimal; Pandey, Kavita

    2009-01-01

    In this paper we present the results of a study of the spatial distribution and asymmetry of solar active prominences (SAP) for the period 1996-2007 (solar cycle 23). For more meaningful statistical analysis we have analysed the distribution and asymmetry of SAP in two subdivisions viz. Group1 (ADF, APR, DSF, CRN, CAP) and Group2 (AFS, ASR, BSD, BSL, DSD, SPY, LPS). The north-south (N-S) latitudinal distribution shows that the SAP events are most prolific in the 21-30degree slice in the northern and southern hemispheres and east-west (E-W) longitudinal distribution study shows that the SAP events are most prolific (best visible) in the 81-90degree slice in the eastern and western hemispheres. It has been found that the SAP activity during this cycle is low compared to previous solar cycles. The present study indicates that during the rising phase of the cycle the number of SAP events were roughly equal on the north and south hemispheres. However, activity on the southern hemisphere has been dominant since 199...

  5. Solar magnetic activity cycles, coronal potential field models and eruption rates

    Petrie, Gordon

    2013-07-01

    We study the evolution of the observed photospheric magnetic field and the modeled global coronal magnetic field during the past 3 1/2 solar activity cycles observed since the mid-1970s. We use synoptic magnetograms and extrapolated potential-field models based on longitudinal full-disk photospheric magnetograms from the NSO's three magnetographs at Kitt Peak, the Synoptic Optical Long-term Investigations of the Sun (SOLIS) vector spectro-magnetograph (VSM), the spectro-magnetograph and the 512-channel magnetograph instruments, and from the U. Stanford's Wilcox Solar Observatory. The associated multipole field components are used to study the dominant length scales and symmetries of the coronal field. Of the axisymmetric multipoles, only the dipole and octupole follow the poles whereas the higher orders follow the activity cycle. All non-axisymmetric multipole strengths are well correlated with the activity cycle. The axial dipole and octupole are the largest contributors to the global field except while the polar fields are reversing. This influence of the polar fields extends to modulating eruption rates. According to the Computer Aided CME Tracking (CACTus), Solar Eruptive Event Detection System (SEEDS), and Nobeyama radioheliograph prominence eruption catalogs, the rate of solar eruptions is found to be systematically higher for active years between 2003-2012 than for those between 1997-2002. This behavior appears to be connected with the weakness of the late-cycle 23 polar fields as suggested by Luhmann. We see evidence that the process of cycle 24 field reversal is well advanced at both poles.

  6. Sounding stellar cycles with Kepler - preliminary results from ground-based chromospheric activity measurements

    Karoff, C; Chaplin, W J; Frandsen, S; Grundahl, F; Kjeldsen, H; Buzasi, D; Arentoft, T; Christensen-Dalsgaard, J

    2009-01-01

    Due to its unique long-term coverage and high photometric precision, observations from the Kepler asteroseismic investigation will provide us with the possibility to sound stellar cycles in a number of solar-type stars with asteroseismology. By comparing these measurements with conventional ground-based chromospheric activity measurements we might be able to increase our understanding of the relation between the chromospheric changes and the changes in the eigenmodes. In parallel with the Kepler observations we have therefore started a programme at the Nordic Optical Telescope to observe and monitor chromospheric activity in the stars that are most likely to be selected for observations for the whole satellite mission. The ground-based observations presented here can be used both to guide the selection of the special Kepler targets and as the first step in a monitoring programme for stellar cycles. Also, the chromospheric activity measurements obtained from the ground-based observations can be compared with s...

  7. Daytime spikes in dopaminergic activity drive rapid mood-cycling in mice.

    Sidor, M M; Spencer, S M; Dzirasa, K; Parekh, P K; Tye, K M; Warden, M R; Arey, R N; Enwright, J F; Jacobsen, J P R; Kumar, S; Remillard, E M; Caron, M G; Deisseroth, K; McClung, C A

    2015-11-01

    Disruptions in circadian rhythms and dopaminergic activity are involved in the pathophysiology of bipolar disorder, though their interaction remains unclear. Moreover, a lack of animal models that display spontaneous cycling between mood states has hindered our mechanistic understanding of mood switching. Here, we find that mice with a mutation in the circadian Clock gene (ClockΔ19) exhibit rapid mood-cycling, with a profound manic-like phenotype emerging during the day following a period of euthymia at night. Mood-cycling coincides with abnormal daytime spikes in ventral tegmental area (VTA) dopaminergic activity, tyrosine hydroxylase (TH) levels and dopamine synthesis. To determine the significance of daytime increases in VTA dopamine activity to manic behaviors, we developed a novel optogenetic stimulation paradigm that produces a sustained increase in dopamine neuronal activity and find that this induces a manic-like behavioral state. Time-dependent dampening of TH activity during the day reverses manic-related behaviors in ClockΔ19 mice. Finally, we show that CLOCK acts as a negative regulator of TH transcription, revealing a novel molecular mechanism underlying cyclic changes in mood-related behavior. Taken together, these studies have identified a mechanistic connection between circadian gene disruption and the precipitation of manic episodes in bipolar disorder. PMID:25560763

  8. Lipotoxicity in steatohepatitis occurs despite an increase in tricarboxylic acid cycle activity.

    Patterson, Rainey E; Kalavalapalli, Srilaxmi; Williams, Caroline M; Nautiyal, Manisha; Mathew, Justin T; Martinez, Janie; Reinhard, Mary K; McDougall, Danielle J; Rocca, James R; Yost, Richard A; Cusi, Kenneth; Garrett, Timothy J; Sunny, Nishanth E

    2016-04-01

    The hepatic tricarboxylic acid (TCA) cycle is central to integrating macronutrient metabolism and is closely coupled to cellular respiration, free radical generation, and inflammation. Oxidative flux through the TCA cycle is induced during hepatic insulin resistance, in mice and humans with simple steatosis, reflecting early compensatory remodeling of mitochondrial energetics. We hypothesized that progressive severity of hepatic insulin resistance and the onset of nonalcoholic steatohepatitis (NASH) would impair oxidative flux through the hepatic TCA cycle. Mice (C57/BL6) were fed a high-trans-fat high-fructose diet (TFD) for 8 wk to induce simple steatosis and NASH by 24 wk. In vivo fasting hepatic mitochondrial fluxes were determined by(13)C-nuclear magnetic resonance (NMR)-based isotopomer analysis. Hepatic metabolic intermediates were quantified using mass spectrometry-based targeted metabolomics. Hepatic triglyceride accumulation and insulin resistance preceded alterations in mitochondrial metabolism, since TCA cycle fluxes remained normal during simple steatosis. However, mice with NASH had a twofold induction (Pcycle (2.6 ± 0.5 vs. 5.4 ± 0.6), anaplerosis (9.1 ± 1.2 vs. 16.9 ± 2.2), and pyruvate cycling (4.9 ± 1.0 vs. 11.1 ± 1.9) compared with their age-matched controls. Induction of the TCA cycle activity during NASH was concurrent with blunted ketogenesis and accumulation of hepatic diacylglycerols (DAGs), ceramides (Cer), and long-chain acylcarnitines, suggesting inefficient oxidation and disposal of excess free fatty acids (FFA). Sustained induction of mitochondrial TCA cycle failed to prevent accretion of "lipotoxic" metabolites in the liver and could hasten inflammation and the metabolic transition to NASH. PMID:26814015

  9. Review of the IAEA Nuclear Fuel Cycle Materials Section activities related to WWER fuel

    The IAEA Nuclear Fuel Cycle Programme, designated as Programme B, has the main objective of supporting Member States in policy making, strategic planning, developing technology and addressing issues with respect to safe, reliable, economically efficient, proliferation resistant and environmentally sound nuclear fuel cycle. This paper is concentrated on describing the work within Sub-programme B.2 'Fuel Performance and Technology'. Two Technical Working Groups assist in the preparation of the IAEA programme in the nuclear fuel cycle area - Technical Working Group on Water Reactor Fuel Performance and Technology and Technical Working Group on Nuclear Fuel Cycle Options. The activities of the Unit within the Nuclear Fuel Cycle and Materials Section working on Fuel Performance and Technology are given, based on the sub-programme structure of the Agency programme and budget for 2002-2003. Within the framework of Co-ordinated Research Projects a study of the delayed hydride cracking (DHC) of the zirconium alloys used in pressurised heavy water reactors (PHWR) involving 10 countries has been completed. It achieved very effective transfer of know-how at the laboratory level in three technologically important areas: 1) Controlled hydriding of samples to predetermined levels; 2) Accurate measurement of hydrogen concentrations at the relatively low levels found in pressure tubes and RBMK channel tubes; and 3) In the determination of DHC rates under various conditions of temperature and stress. A new project has been started on the 'Improvement of Models used for Fuel Behaviour Simulation' (FUMEX II) to assist Member States in improving the predictive capabilities of computer codes used in modelling fuel behaviour for extended burnup. The IAEA also collaborates with organisations in the Member States to support activities and meetings on nuclear fuel cycle related topics

  10. Postnatal telomere dysfunction induces cardiomyocyte cell-cycle arrest through p21 activation.

    Aix, Esther; Gutiérrez-Gutiérrez, Óscar; Sánchez-Ferrer, Carlota; Aguado, Tania; Flores, Ignacio

    2016-06-01

    The molecular mechanisms that drive mammalian cardiomyocytes out of the cell cycle soon after birth remain largely unknown. Here, we identify telomere dysfunction as a critical physiological signal for cardiomyocyte cell-cycle arrest. We show that telomerase activity and cardiomyocyte telomere length decrease sharply in wild-type mouse hearts after birth, resulting in cardiomyocytes with dysfunctional telomeres and anaphase bridges and positive for the cell-cycle arrest protein p21. We further show that premature telomere dysfunction pushes cardiomyocytes out of the cell cycle. Cardiomyocytes from telomerase-deficient mice with dysfunctional telomeres (G3 Terc(-/-)) show precocious development of anaphase-bridge formation, p21 up-regulation, and binucleation. In line with these findings, the cardiomyocyte proliferative response after cardiac injury was lost in G3 Terc(-/-) newborns but rescued in G3 Terc(-/-)/p21(-/-) mice. These results reveal telomere dysfunction as a crucial signal for cardiomyocyte cell-cycle arrest after birth and suggest interventions to augment the regeneration capacity of mammalian hearts. PMID:27241915

  11. Effectiveness and Student Perceptions of an Active Learning Activity Using a Headline News Story to Enhance In-Class Learning of Cell Cycle Regulation

    Dirks-Naylor, Amie J.

    2016-01-01

    An active learning activity was used to engage students and enhance in-class learning of cell cycle regulation in a PharmD level integrated biological sciences course. The aim of the present study was to determine the effectiveness and perception of the in-class activity. After completion of a lecture on the topic of cell cycle regulation,…

  12. Measuring brain activity cycling (BAC) in long term EEG monitoring of preterm babies

    Measuring fluctuation of vigilance states in early preterm infants undergoing long term intensive care holds promise for monitoring their neurological well-being. There is currently, however, neither objective nor quantitative methods available for this purpose in a research or clinical environment. The aim of this proof-of-concept study was, therefore, to develop quantitative measures of the fluctuation in vigilance states or brain activity cycling (BAC) in early preterm infants. The proposed measures of BAC were summary statistics computed on a frequency domain representation of the proportional duration of spontaneous activity transients (SAT%) calculated from electroencephalograph (EEG) recordings. Eighteen combinations of three statistics and six frequency domain representations were compared to a visual interpretation of cycling in the SAT% signal. Three high performing measures (band energy/periodogram: R = 0.809, relative band energy/nonstationary frequency marginal: R = 0.711, g-statistic/nonstationary frequency marginal: R = 0.638) were then compared to a grading of sleep wake cycling based on the visual interpretation of the amplitude-integrated EEG trend. These measures of BAC are conceptually straightforward, correlate well with the visual scores of BAC and sleep wake cycling, are robust enough to cope with the technically compromised monitoring data available in intensive care units, and are recommended for further validation in prospective studies. (paper)

  13. Effect of seat positions on discomfort, muscle activation, pressure distribution and pedal force during cycling.

    Verma, Rachita; Hansen, Ernst A; de Zee, Mark; Madeleine, Pascal

    2016-04-01

    The aim of this study was to measure and analyse discomfort and biomechanics of cycling, i.e., muscle activation, centre of pressure of seat pressure profiles and pedal forces as a function of seat position. Twenty-one recreationally active individuals cycled for 10min at 100W on an ergometer cycle using five different seat positions. The neutral position was considered as basic seat position and was compared with upward, downward, forward and backward seat positions. The initial bout was repeated at the end of the recording session. Discomfort increased for upward and backward condition compared with neutral (P<0.05). Normalized surface electromyography from gastrocnemius decreased in the downward and forward position but increased in the upward and backward position. The minimum force became less negative for forward position compared with neutral seat position (P<0.05). The degree of variability of centre of pressure increased in the upward and backward position and the entropy of the centre of pressure of sitting posture for backward position decreased compared with neutral seat position (P<0.05). The present study revealed that consecutive changes of seat position over time lead to increase in discomfort as well as alterations of the biomechanics of cycling. PMID:26938676

  14. Compatibility of accounting information systems (AISs with activities in production cycle

    Farnaz Vali Moghaddam Zanjani

    2013-01-01

    Full Text Available The intricacies of economic activities and growing increase in competition have made commercial units with the duty of production and financial data processing, orienting themselves with production cycle. This is considered as the heart of organization such that they could be more effective in decision-making. The method adopted in this research is descriptive – survey and it attempts to attain the objectives the researchers based on four independent variables including Production design, Programming, production operations and cost accounting. To test the hypotheses, the study adopts one sample T test method and to investigate uniformity of effects of each variable, Kruscal-Wallis test is employed. The results obtained from the tests indicate that AISs are not compatible with production cycle, where, in turn, has led to rejection of modern costing systems such as activity based costing (ABC.

  15. Environmental impact associated with activated carbon preparation from olive-waste cake via life cycle assessment

    Hjaila, Kefah; Baccar, Rym; Sarrà, Montserrat; Gasol, C.M.; Blánquez, Paqui

    2013-01-01

    he life cycle assessment (LCA) environmental tool was implemented to quantify the potential environmental impacts associated with the activated carbon (AC) production process from olive-waste cakes in Tunisia. On the basis of laboratory investigations for AC preparation, a flowchart was developed and the environmental impacts were determined. The LCA functional unit chosen was the production of 1 kg of AC from by-product olive-waste cakes. The results showed that impregnation using H3PO4 pres...

  16. A Comparative Energetic Analysis of Active and Passive Emission Control Systems Adopting Standard Emission Test Cycles

    Angelo Algieri; Mario Amelio; Pietropaolo Morrone

    2012-01-01

    The present work aims at analysing and comparing the thermal performances of active and passive aftertreatment systems. A one-dimensional transient model has been developed in order to evaluate the heat exchange between the solid and the exhaust gas and to estimate the energy effectiveness of the apparatus. Furthermore, the effect of the engine operating conditions on the performances of emission control systems has been investigated considering standard emission test cycles. The analysis has...

  17. Meridional flow velocities on solar-like stars with known activity cycles

    Baklanova, Dilyara

    2014-01-01

    The direct measurements of the meridional flow velocities on stars are impossible today. To evaluate the meridional flow velocities on solar-like stars with stable activity periods, we supposed that during the stellar Hale cycle the matter on surfaces of stars passes the meridional way equivalent to $2\\pi R_\\star$. We present here the dependence of the mean meridional flow velocity on Rossby number, which is an effective parameter of the stellar magnetic dynamo.

  18. Integrated gasification combined-cycle research development and demonstration activities in the U.S.

    Ness, H.M.

    1994-12-31

    The United States Department of Energy (DOE) has selected seven integrated gasification combined-cycle (IGCC) advanced power systems for demonstration in the Clean Coal Technology (CCT) Program. DOE`s Office of Fossil Energy, Morgantown Energy Technology Center, is managing a research development and demonstration (RD&D)program that supports the CCT program, and addresses long-term improvements in support of IGCC technology. This overview briefly describes the CCT projects and the supporting RD&D activities.

  19. Assessment report of research and development activities in FY2006 activity. 'Fast reactor cycle technology development project' (Interim report)

    Japan Atomic Energy Agency (hereinafter referred to as 'JAEA') asked the advisory committee 'evaluation Committee of Research and Development (R and D) Activities for Advanced Nuclear System/Nuclear Fuel Cycle Technology' (hereinafter referred to as 'Committee') to assess the interim report on Fast Reactor Cycle Technology Development Project ' (former 'Feasibility Study on Commercialized Fast Reactor Cycle Systems') in FY2006, in accordance with 'General Guideline for the Evaluation of Government R and D Activities' by Japanese Cabinet Office, 'Guideline for Evaluation of R and D in Ministry of Education, Culture Sports, Science and Technology' and 'Regulation on Conduct for Evaluation of R and D Activities' by JAEA. In response to JAEA's request, the Committee assessed the R and D program over five years, the criteria for adoption judgment on innovative technologies at the end of 2010 (Project Review), and the organization structure for R and D. etc. (Management Review). As a result of review, the Committee concluded that this R and D program and its organization structure are almost reasonable. (author)

  20. IAEA Activities in the Area of Fast Reactors and Related Fuels and Fuel Cycles

    In the actual context of growing energy needs on one side and concerns for the environment on the other, it is generally recognized that innovative fast reactors and fuel cycle concepts will be able to provide a relevant contribution to future energy needs, if the research and technology developments create the conditions to clearly satisfy the criteria of economic competitiveness, stringent safety requirements, sustainable development and public acceptability. For more than 45 years, the IAEA has been accompanying and supporting the development and deployment of the fast reactor technology, serving the interested Member States as a major forum for fast reactor information exchange and collaborative research and technology development. In particular, since 1967 the keystone of the IAEA’s efforts in this field is represented by the Technical Working Group on Fast Reactors (TWG-FR), which is a group of experts tasked to provide advice and support programme implementation, reflecting a global network of excellence and expertise in the area of advanced technologies and R&D for fast reactors. The TWG-FR coordinates its activities with other IAEA projects, especially those of the Technical Working Group on Nuclear Fuel Cycle Options (TWG-NFCO), the Department of Nuclear Sciences and Applications, the Department of Nuclear Safety and Security and, last but not least, the International Project on Innovative Nuclear Reactors and the Fuel Cycle (INPRO). Among the broad spectrum of IAEA activities in this field, the coordinated research projects (CRPs) represent the major tool to enhance Member States’ knowledge and technical capabilities in the different fields of the fast reactor technology, as well as to promote international cooperation and sharing of knowledge. With regard to the last purpose, the IAEA regularly organizes technical meetings and conferences to discuss the main technology challenges facing the deployment of fast reactors and advanced fuel cycles, to

  1. Luteinizing hormone-releasing hormone fusion protein vaccines block estrous cycle activity in beef heifers.

    Stevens, J D; Sosa, J M; deAvila, D M; Oatley, J M; Bertrand, K P; Gaskins, C T; Reeves, J J

    2005-01-01

    Two LHRH fusion proteins, thioredoxin and ovalbumin, each containing seven LHRH inserts were tested for their ability to inhibit estrous cycle activity. The objective was to evaluate immune and biological responses from alternating the two fusion proteins in an immunization schedule. One hundred ten heifers were divided equally into 11 groups. Two control groups consisted of either spayed or intact, untreated heifers. Heifers in the other nine groups were immunized on wk 0, 4, and 9. Treatments were immunizations of the same protein throughout or alternating the proteins in different booster sequences. Blood was collected weekly for 22 wk, and serum was assayed for concentrations of progesterone and titers of anti-LHRH. At slaughter, reproductive tracts were removed from each heifer and weighed. Heifers with >or=1 ng/mL of progesterone were considered to have a functional corpus luteum and thus to have estrous cycle activity. All LHRH-immunized groups of heifers had a smaller (P spayed heifers during wk 9 to 22. Anti-LHRH did not differ among immunized groups during wk 1 to 9. Starting at wk 10 and continuing through the conclusion of the study, there was an overall difference among treatment groups for anti-LHRH (P spaying in suppression of estrous cycle activity, but alternating the two proteins in an immunization schedule did not enhance the immunological or biological effectiveness of the vaccine. PMID:15583055

  2. IAEA Activities on Uranium Resources and Production, and Databases for the Nuclear Fuel Cycle

    In recent years rising expectation for nuclear power has led to a significant increase in the demand for uranium and in turn dramatic increases in uranium exploration, mining and ore processing activities worldwide. Several new countries, often with limited experience, have also embarked on these activities. The ultimate goal of the uranium raw material industry is to provide an adequate supply of uranium that can be delivered to the market place at a competitive price by environmentally sound, mining and milling practices. The IAEA’s programme on uranium raw material encompass all aspects of uranium geology and deposits, exploration, resources, supply and demand, uranium mining and ore processing, environmental issues in the uranium production cycle and databases for the uranium fuel cycle. Radiological safety and environmental protection are major challenges in uranium mines and mills and their remediation. The IAEA has revived its programme for the Uranium Production Site Appraisal Team (UPSAT) to assist Member States to improve operational and safety performances at uranium mines and mill sites. The present paper summarizes the ongoing activities of IAEA on uranium raw material, highlighting the status of global uranium resources, their supply and demand, the IAEA database on world uranium deposit (UDEPO) and nuclear fuel cycle information system (NFCIS), recent IAEA Technical Meetings (TM) and related ongoing Technical Cooperation (TC) projects. (author)

  3. Conditional inactivation of PDCD2 induces p53 activation and cell cycle arrest

    Celine J. Granier

    2014-08-01

    Full Text Available PDCD2 (programmed cell death domain 2 is a highly conserved, zinc finger MYND domain-containing protein essential for normal development in the fly, zebrafish and mouse. The molecular functions and cellular activities of PDCD2 remain unclear. In order to better understand the functions of PDCD2 in mammalian development, we have examined PDCD2 activity in mouse blastocyst embryos, as well as in mouse embryonic stem cells (ESCs and embryonic fibroblasts (MEFs. We have studied mice bearing a targeted PDCD2 locus functioning as a null allele through a splicing gene trap, or as a conditional knockout, by deletion of exon2 containing the MYND domain. Tamoxifen-induced knockout of PDCD2 in MEFs, as well as in ESCs, leads to defects in progression from the G1 to the S phase of cell cycle, associated with increased levels of p53 protein and p53 target genes. G1 prolongation in ESCs was not associated with induction of differentiation. Loss of entry into S phase of the cell cycle and marked induction of nuclear p53 were also observed in PDCD2 knockout blastocysts. These results demonstrate a unique role for PDCD2 in regulating the cell cycle and p53 activation during early embryonic development of the mouse.

  4. Activities in front-end of uranium fuel cycle in IAEA

    The Nuclear Fuel Cycle and Materials Section (NFC and MS) in the Division of Nuclear Fuel Cycle and Waste Technology (NEFW) under the Department of Nuclear Energy (NE) of IAEA implements Major Programme 1.B. of the Agency. NFC and MS fosters development of nuclear fuel cycle options that are safe, environment-friendly, economically viable and proliferation-resistant. It promotes information exchange on exploration, mining and processing of uranium and thorium, design, manufacturing, and performance of nuclear fuels, management of spent fuel, including storage and treatment of spent fuel and recycling of plutonium and uranium fuels, and development of advanced and innovative nuclear fuels and fuel cycles through Technical Co-operation, preparation of state-of-theart technical documents, technical meetings, symposia and Coordinated Research Projects (CRP) and databases on nuclear fuels and fuel cycles. The present paper summarizes the portions of the Major Programme 1.B. of IAEA, related to the front-end of uranium fuel cycle, highlighting the activities on uranium supply and demand, exploration, production cycle and environment, the databases, and the technical documents (IAEA/TECDOC) that have been published or under preparation in these areas during the last five years. It reports on the IAEA/OECD-NEA Uranium Red Book, the IAEA database on world distribution of uranium deposits (UDEPO)and the IAEA database on nuclear fuel cycle information system (INFCIS). It discusses the environmental issues in the front-end of the uranium production cycle including mining, milling, chemical purification and long-term management of mine tails, residual materials and radioactive wastes, which are of paramount importance to the uranium industry. The Agency provides guidance on best practices in the planning, operation and closure of uranium production facilities including mine reclamation, from the perspective of changing environmental regulations in mining facilities and growing

  5. Stellar activity as noise in exoplanet detection - I. Methods and application to solar-like stars and activity cycles

    Korhonen, H.; Andersen, J. M.; Piskunov, N.; Hackman, T.; Juncher, D.; Järvinen, S. P.; Jørgensen, U. G.

    2015-04-01

    The detection of exoplanets using any method is prone to confusion due to the intrinsic variability of the host star. We investigate the effect of cool starspots on the detectability of the exoplanets around solar-like stars using the radial velocity method. For investigating this activity-caused `jitter' we calculate synthetic spectra using radiative transfer, known stellar atomic and molecular lines, different surface spot configurations and an added planetary signal. Here, the methods are described in detail, tested and compared to previously published studies. The methods are also applied to investigate the activity jitter in old and young solar-like stars, and over a solar-like activity cycles. We find that the mean full jitter amplitude obtained from the spot surfaces mimicking the solar activity varies during the cycle approximately between 1 and 9 m s-1. With a realistic observing frequency a Neptune-mass planet on a 1-yr orbit can be reliably recovered. On the other hand, the recovery of an Earth-mass planet on a similar orbit is not feasible with high significance. The methods developed in this study have a great potential for doing statistical studies of planet detectability, and also for investigating the effect of stellar activity on recovered planetary parameters.

  6. Computational Modeling for the Activation Cycle of G-proteins by G-protein-coupled Receptors

    Bao, Yifei; Glavy, Joseph; White, Tommy; 10.4204/EPTCS.40.4

    2010-01-01

    In this paper, we survey five different computational modeling methods. For comparison, we use the activation cycle of G-proteins that regulate cellular signaling events downstream of G-protein-coupled receptors (GPCRs) as a driving example. Starting from an existing Ordinary Differential Equations (ODEs) model, we implement the G-protein cycle in the stochastic Pi-calculus using SPiM, as Petri-nets using Cell Illustrator, in the Kappa Language using Cellucidate, and in Bio-PEPA using the Bio-PEPA eclipse plug in. We also provide a high-level notation to abstract away from communication primitives that may be unfamiliar to the average biologist, and we show how to translate high-level programs into stochastic Pi-calculus processes and chemical reactions.

  7. An ocean-atmosphere interaction mechanism for the active break cycle of the Asian summer monsoon

    Joseph, P.V.; Sabin, T.P. [Cochin University of Science and Technology, Department of Atmospheric Sciences, Cochin (India)

    2008-05-15

    A typical active-break cycle of the Asian summer monsoon is taken as beginning with maximum SST (pentad 0) over the north Bay of Bengal when the oceans to its west and east from longitude 40 -160 E, and between latitudes 10 and 25 N (area A) also has maximum SST. During this pentad the recently found 'Cold Pool' of the Bay of Bengal (between latitudes 3 N and 10 N) has its minimum SST. An area of convection takes genesis over the Bay of Bengal immediately after pentad 0 in the zone of large SST gradient north of the Cold Pool and it pulls the monsoon Low Level Jetstream (LLJ) through peninsular India. Convection and the LLJ westerlies then spread to the western Pacific Ocean during pentads 1-4 taken as the active phase of the monsoon during which convection and LLJ have grown in a positive feed back process. The cyclonic vorticity to the north of the LLJ axis is hypothesized to act as a flywheel maintaining the convection during the long active phase against the dissipating effect of atmospheric stabilization by each short spell of deep convection. By the end of pentad 4 the SST over area A has cooled and the convection weakens there, when the LLJ turns clockwise over the Arabian Sea and flows close to the equator in the Indian ocean. A band of convection develops at pentad 5 between the equator and latitude 10 S over the Indian ocean and it is nourished by the cyclonic vorticity of the LLJ now near the equator and the moisture supply through it. This is taken as the break monsoon phase lasting for about three to four pentads beginning from pentad 5 of a composite active-break cycle of 40 day duration. With reduced wind and convection over the area A during the break phase, solar radiation and light winds make the SST there warm rapidly and a new active-break cycle begins. SST, convection, LLJ and the net heat flux at the ocean surface have important roles in this new way of looking at the active-break cycle as a coupled ocean-atmosphere phenomenon. (orig.)

  8. Stellar activity as noise in exoplanet detection I. Methods and application to solar-like stars and activity cycles

    Korhonen, H; Piskunov, N; Hackman, T; Juncher, D; Jarvinen, S P; Joergensen, U G

    2015-01-01

    The detection of exoplanets using any method is prone to confusion due to the intrinsic variability of the host star. We investigate the effect of cool starspots on the detectability of the exoplanets around solar-like stars using the radial velocity method. For investigating this activity-caused "jitter" we calculate synthetic spectra using radiative transfer, known stellar atomic and molecular lines, different surface spot configurations, and an added planetary signal. Here, the methods are described in detail, tested and compared to previously published studies. The methods are also applied to investigate the activity jitter in old and young solar-like stars, and over a solar-like activity cycles. We find that the mean full jitter amplitude obtained from the spot surfaces mimicking the solar activity varies during the cycle approximately between 1 m/s and 9 m/s. With a realistic observing frequency a Neptune mass planet on a one year orbit can be reliably recovered. On the other hand, the recovery of an Ea...

  9. Increased Mesohippocampal Dopaminergic Activity and Improved Depression-Like Behaviors in Maternally Separated Rats Following Repeated Fasting/Refeeding Cycles

    Jeong Won Jahng; Sang Bae Yoo; Jin Young Kim; Bom-Taeck Kim; Jong-Ho Lee

    2012-01-01

    We have previously reported that rats that experienced 3 h of daily maternal separation during the first 2 weeks of birth (MS) showed binge-like eating behaviors with increased activity of the hypothalamic-pituitary-adrenal axis when they were subjected to fasting/refeeding cycles repeatedly. In this study, we have examined the psychoemotional behaviors of MS rats on the fasting/refeeding cycles, together with their brain dopamine levels. Fasting/refeeding cycles normalized the ambulatory act...

  10. The role of circulating sex hormones in menstrual cycle dependent modulation of pain-related brain activation

    Veldhuijzen, Dieuwke S.; Keaser, Michael L.; Traub, Deborah S.; Zhuo, Jiachen; Gullapalli, Rao P.; Greenspan, Joel D.

    2013-01-01

    Sex differences in pain sensitivity have been consistently found but the basis for these differences is incompletely understood. The present study assessed how pain-related neural processing varies across the menstrual cycle in normally cycling, healthy females, and whether menstrual cycle effects are based on fluctuating sex hormone levels. Fifteen subjects participated in four test sessions during their menstrual, mid-follicular, ovulatory, and midluteal phases. Brain activity was measured ...

  11. A mechanistic examination of redox cycling activity in carbonaceous particulate matter

    McWhinney, Robert David

    Mechanistic aspects of carbonaceous aerosol toxicity were examined with respect to the ability of particles to catalyse reactive oxygen species-generating redox cycling reactions. To investigate the role of secondary organic material, we examined two systems. In the first, two-stroke engine exhaust particles were found to increase their ability to catalyse redox cycling in the presence of a reducing agent, dithiothreitol (DTT), when the exhaust was exposed to ozone. This occurred through deposition of redox-active secondary organic aerosol (SOA) onto the particle that was ten times more redox active per microgram than the primary engine particle. In the second system, naphthalene SOA formed highly redox active particles. Activity was strongly correlated to the amount of the 1,4- and 1,2-naphthoquinone measured in the particle phase. However, these species and the newly quantified naphthalene oxidation product 5-hydroxy-1,4-naphthoquinone accounted for only 30% of the observed DTT decay from the particles. Gas-particle partitioning coefficients suggest 1,4- and 1,2- naphthoquinone are not strong contributors to ambient particle redox activity at 25 °C. However, a large number of redox active species are unidentified. Some of these may be highly oxidised products of sufficiently low vapour pressure to be atmospherically relevant. DTT activity of diesel particles was found to be high per unit mass. The activity was found to be associated with the insoluble fraction as filtration of the particles nearly eliminated DTT decay. Neither methanol nor dichloromethane extracts of diesel particles exhibited redox activity, indicating that the redox active species are associated with the black carbon portion of the particles. Examination of particle concentration techniques found that use of water condensation to grow and concentrate particles introduced a large organic artefact to the particles. Experiments with concentrated inorganic particles suggest that the source of this

  12. Validation of activity questionnaires in patients with cystic fibrosis by accelerometry and cycle ergometry

    Ruf Katharina C

    2012-04-01

    Full Text Available Abstract Background The objective of this study was to validate physical activity questionnaires for cystic fibrosis (CF against accelerometry and cycle ergometry. Methods 41 patients with CF (12-42 years completed the Habitual Activity Estimation Scale (HAES, the 7-Day Physical Activity Recall questionnaire (7D-PAR and the Lipid Research Clinics questionnaire (LRC and performed an incremental exercise test according to the Godfrey protocol up to volitional fatigue. Time spent in moderate and vigorous physical activity (MVPA assessed objectively by accelerometry was related to the time spent in the respective activity categories by correlation analyses and calculating intraclass correlation coefficients (ICC. Furthermore, the results of the exercise test were correlated with the results of the questionnaires. Results Time spent in the categories 'hard','very hard' and 'hard & very hard' of the 7D-PAR (0.41 p = 0.002; VO2peak: r = 0.32, p = 0.041. Conclusions In conclusion, the activity categories 'hard' and 'very hard' of the 7D-PAR best reflected objectively measured MVPA. Since the association was at most moderate, the 7D-PAR may be selected to describe physical activity within a population. None of the evaluated questionnaires was able to generate valid physical activity data exercise performance data at the individual level. Neither did any of the questionnaires provide a valid assessment of aerobic fitness on an invidual level.

  13. IAEA activities on uranium resources and production and databases for the nuclear fuel cycle

    Full text: Natural uranium (∼99.3% U-238+ ∼ 0.7 % U-235) is the basic raw material for nuclear fuel. The present generation of nuclear power reactors derive energy from the 'fission' of U-235, the only 'fissile' isotope in nature. These reactors also transmute the more abundant U-238 to man-made fissile isotope Pu-239, which could be subjected to multiple recycling, as fuel, in fast reactor for efficient utilization of natural uranium resources and to ensure long term sustainability of nuclear energy. Uranium is mostly mined and produced in countries without a nuclear power programme. On the other hand, uranium is mostly consumed in countries with nuclear power, but having no uranium. In recent years, rising expectation for nuclear power has led to increase in uranium exploration, mining and ore processing activities all over the world and several new countries, with a limited experience, have embarked on uranium exploration, mining and production. Uranium and its daughter products are radioactivity and health hazardous. Radiological safety is a major challenge in uranium production cycle and in uranium mine and mill remediation and reclamation. Another specific challenge being faced currently by uranium raw material industry is the retired or ageing manpower and lack of experienced staff around the world. The IAEA's programme on 'Uranium Resources and Production and Databases for the Nuclear Fuel Cycle' encompass all aspects of uranium geology and deposits, exploration, resources, supply and demand, uranium mining and processing, environmental issues related to uranium production cycle and databases for uranium fuel cycle. The IAEA collaborates with OECD/NEA in producing an authoritative and updated document on uranium resources, production and demand, popularly known as Red Book, which is published biennially by OECD/NEA. As a spin-off from uranium resources activities, two reports titled, 'Analysis of Uranium to 2060' and 'Red Book Retrospective - Country

  14. North-south asymmetry of different solar activity features during solar cycle 23

    Bankoti, Neeraj Singh; Joshi, Navin Chandra; Pande, Seema; Pande, Bimal; Pandey, Kavita

    2010-08-01

    A study on north-south (N-S) asymmetry of different solar activity features (DSAF) such as solar proton events, solar active prominences [total, low (⩽40°) and high (⩾50°) latitudes], H α flare indices, soft X-ray flares, monthly mean sunspot areas and monthly mean sunspot numbers carried out from May 1996 to October 2008. Study shows a southern dominance of DSAF during this period. During the rising phase of the cycle 23 the number of DSAF approximately equals on both, the northern and the southern hemispheres. But these activities tend to shift from northern to southern hemisphere during the period 1998-1999. The statistical significance of the asymmetry time series using a χ2-test of goodness of fit indicates that in most of the cases the asymmetry is highly significant, meaning thereby that the asymmetry is a real feature in the N-S distribution of DSAF.

  15. Solar activity phase diagram and forecast of the coming 23rd cycle.

    Pankratov, A. K.; Narmanskij, V. Ya.; Vladimirskij, B. M.

    1998-10-01

    The phase diagram method is used for investigation of relations between planetary dynamics and solar activity variations. It was found that the calculated moments of solar activity maxima/minima are disposed regularly in the coordinates of the difference of heliocentric longitudes of Uranus-Neptune versus the difference of heliocentric longitudes of Saturn-Neptune. There are separate zones containing maxima (minima) of only the northern (or southern) polarity of solar mean magnetic field. There is also a region where only maxima of small amplitudes are concentrated (Rz cycle. The minimum of activity must be observed in 1999±2. The maximum is forecast in 2006±2. The amplitude Rz can be as small as 60±20. Probably there will be no change of the polarity of the mean solar magnetic field.

  16. Assessment report of research and development activities in JFY2008 activity. 'Fast Reactor Cycle Technology Development Project' (Interim report)

    Japan Atomic Energy Agency (hereinafter referred to as 'JAEA') asked the advisory committee 'Evaluation Committee of Research and Development Activities for Advanced Nuclear System/Nuclear Fuel Cycle Technology' (hereinafter referred to as 'Committee') to assess the interim report on 'Fast Reactor Cycle Technology Development Project (FaCT project)' in JFY2008, in accordance with 'General Guideline for the Evaluation of Government R and D Activities' by Japanese Cabinet Office, 'Guideline for Evaluation of R and D in Ministry of Education, Culture, Sports, Science and Technology' and 'Regulation on Conduct for Evaluation of R and D Activities' by JAEA. In response of JAEA's request, the Committee assessed the 2006-2008 R and D results, the 2009-2010 R and D program and its R and D management. The Committee confirmed the progress status of the R and D for the adoption judgment on innovative technologies scheduled in 2010. As a result of the review, the committee has made suggestions for the future R and D plan and the improvements of the R and D organization structure/management. A CD-ROM is attached as an appendix. (J.P.N.)

  17. Inhibitory Effects of Berberine on the Activation and Cell Cycle Progression of Human Peripheral Lymphocytes

    Lihui Xu; Yi Liu; Xianhui He

    2005-01-01

    The immunosuppressive property of berberine, an isoquinoline alkaloid, has been well documented, but the mechanism of its action on lymphocytes has not been completely elucidated. The present study is to investigate the effect of berberine on the activation and proliferation of lymphocytes, in particular T lymphocytes. Whole peripheral blood from healthy donors was stimulated with phytohemagglutinin (PHA) alone or phorbol dibutyrate (PDB) plus ionomycin, and the expression of CD69 and CD25 on T lymphocytes was evaluated with flow cytometry.The distribution of cell cycles and cell viability were analyzed by staining with propidium iodide (PI) and 7-aminoactinomycin D (7-AAD), respectively. The results showed that 100 μmol/L and 50 μmol/L of berberine significantly inhibited CD69 expression on T cells stimulated with PDB plus ionomycin or PHA, whereas the effect of 25 μmol/L berberine was not significant. As the incubation time increased, the extent of inhibition decreased.Similarly, the expression of CD25 was also reduced by berberine in a dose-dependent manner over the concentration range of 25-100 μmol/L. Besides, this alkaloid could block lymphocyte cell cycle progression from G0/G1 phase to S and G2/M phase without phase specificity. Moreover, analysis following 7-AAD staining revealed that berberine had no significant cytotoxicity on lymphocytes. Taken together, berberine significantly inhibits the expression of activation antigens on T lymphocytes and also blocks the progression of cell cycles of lymphocytes,suggesting that berberine may exert immunosuppressive effect through inhibiting the activation and proliferation of T cells.

  18. Inflows towards active regions and the modulation of the solar cycle: a parameter study

    Martin-Belda, David

    2016-01-01

    Aims: We aim to investigate how converging flows towards active regions affect the surface transport of magnetic flux, as well as their impact on the generation of the Sun's poloidal field. The inflows constitute a potential non-linear mechanism for the saturation of the global dynamo and may contribute to the modulation of the solar cycle in the Babcock-Leighton framework. Methods: We build a surface flux transport code incorporating a parametrized model of the inflows and run simulations spanning several cycles. We carry out a parameter study to assess how the strength and extension of the inflows affect the build-up of the global dipole field. We also perform simulations with different levels of activity to investigate the potential role of the inflows in the saturation of the global dynamo. Results: We find that the interaction of neighbouring active regions can lead to the occasional formation of single-polarity magnetic flux clumps inconsistent with observations. We propose the darkening caused by pores...

  19. Antiproliferative activity of bicyclic benzimidazole nucleosides: synthesis, DNA-binding and cell cycle analysis.

    Sontakke, Vyankat A; Lawande, Pravin P; Kate, Anup N; Khan, Ayesha; Joshi, Rakesh; Kumbhar, Anupa A; Shinde, Vaishali S

    2016-04-26

    An efficient route was developed for synthesis of bicyclic benzimidazole nucleosides from readily available d-glucose. The key reactions were Vörbruggen glycosylation and ring closing metathesis (RCM). Primarily, to understand the mode of DNA binding, we performed a molecular docking study and the binding was found to be in the minor groove region. Based on the proposed binding model, UV-visible and fluorescence spectroscopic techniques using calf thymus DNA (CT-DNA) demonstrated a non-intercalative mode of binding. Antiproliferative activity of nucleosides was tested against MCF-7 and MDA-MB-231 breast cancer cell lines and found to be active at low micromolar concentrations. Compounds and displayed significant antiproliferative activity as compared to and with the reference anticancer drug, doxorubicin. Cell cycle analysis showed that nucleoside induced cell cycle arrest at the S-phase. Confocal microscopy has been performed to validate the induction of cellular apoptosis. Based on these findings, such modified bicyclic benzimidazole nucleosides will make a significant contribution to the development of anticancer drugs. PMID:27074628

  20. International Project on Innovative Nuclear Reactors and Fuel Cycles: Introduction and Education and Training Activity

    The IAEA’s International Project on Innovative Nuclear Reactors and Fuel Cycles (INPRO) was established in 2000 through IAEA General Conference resolution with aim to ensure that sustainable nuclear energy is available to help meet the energy needs of the 21st century. INPRO seeks to bring together technology holders, users and newcomers to consider jointly the international and national actions required for achieving desired innovations in nuclear reactors and fuel cycles, with a particular focus on sustainability and needs of developing countries. It is a mechanism for INPRO Members to collaborate on topics of joint interest. INPRO activities are undertaken in close cooperation with Member States in the following main areas: Global Scenarios, Innovations, Sustainability Assessment and Strategies, Policy and Dialogue. The paper presents short introduction in INPRO and specifically the distant Education and Training INPRO activity on important topics of nuclear energy sustainability to audiences in different Member States. These activities can support capacity building and national human resource development in the nuclear energy sector. The main benefit of such training courses and workshops is that it is not only targeted to students, but also to lecturers of technical and nuclear universities. Moreover, young professionals working at nuclear energy departments, electric utilities, energy ministries and R&D institutions can participate in such training and benefit from it. (authors) Keywords: nuclear energy sustainability, nuclear education, distant learning, nuclear energy system assessment, educational resources

  1. International Project on Innovative Nuclear Reactors and Fuel Cycles: Introduction and Education and Training Activity

    The IAEA’s International Project on Innovative Nuclear Reactors and Fuel Cycles (INPRO) was established in 2000 through IAEA General Conference resolution with aim to ensure that sustainable nuclear energy is available to help meet the energy needs of the 21st century. INPRO seeks to bring together technology holders, users and newcomers to consider jointly the international and national actions required for achieving desired innovations in nuclear reactors and fuel cycles, with a particular focus on sustainability and needs of developing countries. It is a mechanism for INPRO Members to collaborate on topics of joint interest. INPRO activities are undertaken in close cooperation with Member States in the following main areas: Global Scenarios, Innovations, Sustainability Assessment and Strategies, Policy and Dialogue. The paper presents short introduction in INPRO and specifically the distant Education and Training INPRO activity on important topics of nuclear energy sustainability to audiences in different Member States. These activities can support capacity building and national human resource development in the nuclear energy sector. The main benefit of such training courses and workshops is that it is not only targeted to students, but also to lecturers of technical and nuclear universities. Moreover, young professionals working at nuclear energy departments, electric utilities, energy ministries and R&D institutions can participate in such training and benefit from it. (authors)

  2. On the Relationship Between Solar Wind Speed, Geomagnetic Activity, and the Solar Cycle Using Annual Values

    Wilson, Robert M.; Hathaway, David H.

    2008-01-01

    The aa index can be decomposed into two separate components: the leading sporadic component due to solar activity as measured by sunspot number and the residual or recurrent component due to interplanetary disturbances, such as coronal holes. For the interval 1964-2006, a highly statistically important correlation (r = 0.749) is found between annual averages of the aa index and the solar wind speed (especially between the residual component of aa and the solar wind speed, r = 0.865). Because cyclic averages of aa (and the residual component) have trended upward during cycles 11-23, cyclic averages of solar wind speed are inferred to have also trended upward.

  3. Study of Distribution and Asymmetry of Solar Active Prominences During Solar Cycle 23

    Joshi, Navin Chandra; Bankoti, Neeraj Singh; Pande, Seema; Pande, Bimal; Pandey, Kavita

    2009-01-01

    In this paper we present the results of a study of the spatial distribution and asymmetry of solar active prominences (SAP) for the period 1996-2007 (solar cycle 23). For more meaningful statistical analysis we have analysed the distribution and asymmetry of SAP in two subdivisions viz. Group1 (ADF, APR, DSF, CRN, CAP) and Group2 (AFS, ASR, BSD, BSL, DSD, SPY, LPS). The north-south (N-S) latitudinal distribution shows that the SAP events are most prolific in the 21-30degree slice in the north...

  4. Cytotoxic Activity and G1 Cell Cycle Arrest of a Dienynone from Echinacea pallida

    Chicca, Andrea; Adinolfi, Barbara; Pellati, Federica; Orlandini, Giulia; Benvenuti, Stefania; Nieri, Paola

    2009-01-01

    (Jurkat and HL-60), breast carcinoma (MCF-7), and melanoma (MeWo) cells. As part of its mechanism of action, the ability of this constituent to arrest the cell cycle in the G1 phase was demonstrated on HL-60 cells. Furthermore, a stability test of the target compound over 72 h was carried out, indicating......In the present study, a further investigation of the cytotoxic activity of an acetylenic constituent of ECHINACEA PALLIDA roots, namely, pentadeca-(8 Z,13 Z)-dien-11-yn-2-one, was performed, revealing a concentration-dependent cytotoxicity on several human cancer cell lines, including leukemia...

  5. Study of a magnetic refrigeration cycle by active regeneration between 15 and 4.2 kelvins

    Magnetic refrigeration with active regeneration cycles was realized on a test bench. From a hot source at 14K cold power near 20 mW is reached on liquid helium at 4.2 K. Efficiency of the cooling loop is around 0.20. Different geometries are tested and a part of observed physical phenomena are simulated with a numerical model. Interest of ferromagnetic cryogenic materials for the range 4-15 K is evidenced by measurement of thermomagnetic properties of europium sulfide

  6. Activity-based life-cycle costing in long-range planning

    Edilberto J. Rodríguez Rivero; Jan Emblemsvåg

    2007-01-01

    Purpose – The aim of the paper is to present and illustrate a new approach for long-range planning. Design/methodology/approach – Building on well-tested frameworks such as activity-based costing (ABC), life-cycle costing (LCC) and Monte Carlo methods as well as earlier case studies, an approach is developed further and tested using a real-life case. Findings – The effectiveness of the approach is confirmed using a process-oriented framework (ABC) and introducing an LCC perspective. Monte Car...

  7. Flux-tube geometry and wind speed during an activity cycle

    Pinto, R. F.; Brun, A. S.; Rouillard, A. P.

    2016-01-01

    The solar wind speed at 1 AU shows variations in latitude and in time which reflect the evolution of the global background magnetic field during the activity cycle. It is commonly accepted that the terminal wind speed in a magnetic flux-tube is anti-correlated with its expansion ratio, which motivated the definition of widely-used semi-empirical scaling laws relating one to the other. In practice, such scaling laws require ad-hoc corrections. A predictive law based solely on physical principl...

  8. Investigating the Potential of Activity Tracking App Data to Estimate Cycle Flows in Urban Areas

    Haworth, J.

    2016-06-01

    Traffic congestion and its associated environmental effects pose a significant problem for large cities. Consequently, promoting and investing in green travel modes such as cycling is high on the agenda for many transport authorities. In order to target investment in cycling infrastructure and improve the experience of cyclists on the road, it is important to know where they are. Unfortunately, investment in intelligent transportation systems over the years has mainly focussed on monitoring vehicular traffic, and comparatively little is known about where cyclists are on a day to day basis. In London, for example, there are a limited number of automatic cycle counters installed on the network, which provide only part of the picture. These are supplemented by surveys that are carried out infrequently. Activity tracking apps on smart phones and GPS devices such as Strava have become very popular over recent years. Their intended use is to track physical activity and monitor training. However, many people routinely use such apps to record their daily commutes by bicycle. At the aggregate level, these data provide a potentially rich source of information about the movement and behaviour of cyclists. Before such data can be relied upon, however, it is necessary to examine their representativeness and understand their potential biases. In this study, the flows obtained from Strava Metro (SM) are compared with those obtained during the 2013 London Cycle Census (LCC). A set of linear regression models are constructed to predict LCC flows using SM flows along with a number of dummy variables including road type, hour of day, day of week and presence/absence of cycle lane. Cross-validation is used to test the fitted models on unseen LCC sites. SM flows are found to be a statistically significant (p<0.0001) predictor of total flows as measured by the LCC and the models yield R squared statistics of ~0.7 before considering spatio-temporal variation. The initial results indicate

  9. Cycles of passive versus active diapirism recorded along an exposed salt wall

    Alsop, G. I.; Weinberger, R.; Levi, T.; Marco, S.

    2016-03-01

    Although it has long been recognised that passive salt diapirism may encompass sub-ordinate cycles of active diapirism, where sedimentary overburden is periodically shed off the roof of the rising salt, there has been very little study of this process around exposed salt (halite) diapirs. However, the Late Miocene-Pliocene Sedom salt wall, on the western side of the Dead Sea Basin, presents an opportunity for detailed outcrop analysis of diapiric salt and the associated depositional and deformational record of its movement during both passive and active phases of diapirism. The sub-seismic scale record of diapirism includes sedimentary breccia horizons interpreted to reflect sediments being shed off the crest of the growing salt wall, together with exceptional preservation of rotated unconformities and growth faults. Areas of more pronounced dips directed towards the salt wall are capped by unconformities, and interpreted to represent withdrawal basins within the overburden that extend for at least 1500 m from the salt margin. Elsewhere, broad areas of upturn directed away from the salt extend for up to 1250 m and are marked by a sequence of rotated unconformities which are interpreted to bound halokinetic sequences. The margins of the salt wall are defined by steep extensional boundary faults that cut upturned strata, and have enabled rapid and active uplift of the salt since the Holocene. The Sedom salt wall therefore charts the transition from passive growth marked by withdrawal basins, growth faults and unconformities, to more active intrusion associated with major boundary faults that enable the rapid uplift of overburden deposited on top of the salt to ∼100 m above regional elevations in the past 43 ka. Individual cycles of passive and active diapirism occur over timescales of water level.

  10. Male prairie voles display cardiovascular dipping associated with an ultradian activity cycle.

    Lewis, Robert; Curtis, J Thomas

    2016-03-15

    Mammals typically display alternating active and resting phases and, in most species, these rhythms follow a circadian pattern. The active and resting phases often are accompanied by corresponding physiological changes. In humans, blood pressure decreases during the resting phase of the activity cycle, and the magnitude of that "nocturnal dipping" has been used to stratify patients according to the risk for cardiovascular disease. However, in contrast to most mammals, prairie voles (Microtus ochrogaster) have periods of activity and rest that follow an ultradian rhythm with period lengths significantly humans. Further, the duration of inactivity did not affect any of the cardiovascular measures, so the differences in blood pressure values between the active and inactive periods are likely driven by ultradian oscillations in hormones and autonomic function. Finally, specific behavioral patterns also were examined. Both the instrumented animal and his non-instrumented cagemate appeared to show synchronized activity patterns, with both animals displaying sleep-like behavior for more than 90% of the inactive period. We propose that the prairie vole ultradian rhythm in blood pressure is an analogue for circadian blood pressure variability and can be used to study the long-term effects of commonly prescribed drugs on blood pressure dipping. PMID:26780151

  11. Increased Mesohippocampal Dopaminergic Activity and Improved Depression-Like Behaviors in Maternally Separated Rats Following Repeated Fasting/Refeeding Cycles

    Jeong Won Jahng

    2012-01-01

    Full Text Available We have previously reported that rats that experienced 3 h of daily maternal separation during the first 2 weeks of birth (MS showed binge-like eating behaviors with increased activity of the hypothalamic-pituitary-adrenal axis when they were subjected to fasting/refeeding cycles repeatedly. In this study, we have examined the psychoemotional behaviors of MS rats on the fasting/refeeding cycles, together with their brain dopamine levels. Fasting/refeeding cycles normalized the ambulatory activity of MS rats, which was decreased by MS experience. Depression-like behaviors, but not anxiety, by MS experience were improved after fasting/refeeding cycles. Fasting/refeeding cycles did not significantly affect the behavioral scores of nonhandled (NH control rats. Fasting/refeeding cycles increased dopamine levels not only in the hippocampus but also in the midbrain dopaminergic neurons in MS rats, but not in NH controls. Results demonstrate that fasting/refeeding cycles increase the mesohippocampal dopaminergic activity and improve depression-like behaviors in rats that experienced MS. Together with our previous paper, it is suggested that increased dopamine neurotransmission in the hippocampus may be implicated in the underlying mechanisms by which the fasting/refeeding cycles induce binge-like eating and improve depression-like behaviors in MS rats.

  12. ACTIVE TOURISM. TUSCANY CYCLING - Rapporto sullo studio dello sviluppo di applicazione per social network di realt? aumentata

    Vairo, Claudio; Amato, Giuseppe; Gennaro, Claudio

    2014-01-01

    The goal of this activity is to develop an application for smartphones technologically advanced, in an augmented reality, aimed at cycling tourism object within the project Active Tourism. The application must provide information and images during the cycling routes and should allow you to share with other users, traffic information, cultural sites and scenic resources of the route you are currently taking. The application is designed and built for the iPhone platform with iOS operating syste...

  13. Solar activity during the Holocene: the Hallstatt cycle and its consequence for grand minima and maxima

    Usoskin, I. G.; Gallet, Y.; Lopes, F.; Kovaltsov, G. A.; Hulot, G.

    2016-03-01

    Aims: Cosmogenic isotopes provide the only quantitative proxy for analyzing the long-term solar variability over a centennial timescale. While essential progress has been achieved in both measurements and modeling of the cosmogenic proxy, uncertainties still remain in the determination of the geomagnetic dipole moment evolution. Here we aim at improving the reconstruction of solar activity over the past nine millennia using a multi-proxy approach. Methods: We used records of the 14C and 10Be cosmogenic isotopes, current numerical models of the isotope production and transport in Earth's atmosphere, and available geomagnetic field reconstructions, including a new reconstruction relying on an updated archeo- and paleointensity database. The obtained series were analyzed using the singular spectrum analysis (SSA) method to study the millennial-scale trends. Results: A new reconstruction of the geomagnetic dipole field moment, referred to as GMAG.9k, is built for the last nine millennia. New reconstructions of solar activity covering the last nine millennia, quantified in terms of sunspot numbers, are presented and analyzed. A conservative list of grand minima and maxima is also provided. Conclusions: The primary components of the reconstructed solar activity, as determined using the SSA method, are different for the series that are based on 14C and 10Be. This shows that these primary components can only be ascribed to long-term changes in the terrestrial system and not to the Sun. These components have therefore been removed from the reconstructed series. In contrast, the secondary SSA components of the reconstructed solar activity are found to be dominated by a common ≈2400-year quasi-periodicity, the so-called Hallstatt cycle, in both the 14C and 10Be based series. This Hallstatt cycle thus appears to be related to solar activity. Finally, we show that the grand minima and maxima occurred intermittently over the studied period, with clustering near lows and highs

  14. Methods for dynamic characterization of the major muscles activating the lower limb joints in cycling motion

    Navit Roth

    2014-04-01

    Full Text Available The functional activation, through electrical stimulation, of the lower limb consisting of several deficient muscles requires well-patterned and coordinated activation of these muscles. This study presents a method for characterizing the parameters of the major muscle groups controlling the ankle and knee joints in cycling motion, the latter having particular significance in the rehabilitation of locomotion. To lower mechanical indeterminacy in the joints the system is reduced by grouping the muscles acting in synergism. The joint torques were calculated by inverse dynamics methods from cycling motion data, including kinematics and foot/pedal reaction loads (forces, moments. The mechanical indeterminacy was resolved by applying optimization criteria and the individual muscle torques were parceled-out from the joint torques. System identification of the individual muscles, part of which being bi-articular, in this non-isometric condition was performed from the relationship between the evaluated force and the measured EMG of each the muscles, using both first and second order linear transfer functions. Feasibility of the presented method was demonstrated through the computation of the coefficients of the muscles involved and validating the results on the experimental data obtained from one subject.

  15. Methods for dynamic characterization of the major muscles activating the lower limb joints in cycling motion

    Navit Roth

    2014-09-01

    Full Text Available The functional activation, through electrical stimulation, of the lower limb consisting of several deficient muscles requires well-patterned and coordinated activation of these muscles. This study presents a method for characterizing the parameters of the major muscle groups controlling the ankle and knee joints in cycling motion, the latter having particular significance in the rehabilitation of locomotion. To lower mechanical indeterminacy in the joints the system is reduced by grouping the muscles acting in synergism. The joint torques were calculated by inverse dynamics methods from cycling motion data, including kinematics and foot/pedal reaction loads (forces, moments. The mechanical indeterminacy was resolved by applying optimization criteria and the individual muscle torques were parceled-out from the joint torques. System identification of the individual muscles, part of which being bi-articular, in this non-isometric condition was performed from the relationship between the evaluated force and the measured EMG of each the muscles, using both first and second order linear transfer functions. Feasibility of the presented method was demonstrated through the computation of the coefficients of the muscles involved and validating the results on the experimental data obtained from one subject.

  16. Long-period intensity pulsations in the solar corona during activity cycle 23

    Auchère, F; Solomon, J; Tison, E

    2013-01-01

    We report on the detection ($10\\ \\sigma$) of 917 events of long-period (3 to 16 hours) intensity pulsations in the 19.5 nm passband of the SOHO Extreme ultraviolet Imaging Telescope. The data set spans from January 1997 to July 2010, i.e the entire solar cycle 23 and the beginning of cycle 24. The events can last for up to six days and have relative amplitudes up to 100%. About half of the events (54%) are found to happen in active regions, and 50% of these have been visually associated with coronal loops. The remaining 46% are localized in the quiet Sun. We performed a comprehensive analysis of the possible instrumental artifacts and we conclude that the observed signal is of solar origin. We discuss several scenarios which could explain the main characteristics of the active region events. The long periods and the amplitudes observed rule out any explanation in terms of magnetohydrodynamic waves. Thermal nonequilibrium could produce the right periods, but it fails to explain all the observed properties of c...

  17. Olfactory bulb units - Activity correlated with inhalation cycles and odor quality.

    Macrides, F.; Chorover, S. L.

    1972-01-01

    Single olfactory bulb units were studied in two macrosmatic species of rodents under conditions intended to preserve the cyclical stimulation which normally accompanies nasal breathing. Patterns of unit activity related to the inhalation cycle were observed in all animals, often in the absence of specific stimuli, and could not be explained in simple mechanical terms. Distinctive changes in these patterns occurred in response to certain odors, and were generally independent of changes in the overall firing frequency. These findings indicate that a change in the overall firing frequency of unit discharges is neither a necessary nor sufficient measure of responsiveness to odors in the rodent olfactory bulb, and that stimulus-specific temporal distributions of unit firing may be involved in olfacto-endocrine activities.

  18. ANATOMY OF SOLAR CYCLE LENGTH AND SUNSPOT NUMBER: DEPENDENCE OF AVERAGE GLOBAL TEMPERATURE ON SOLAR ACTIVITY

    Bhattacharya, A. B.; B. RAHA; Das, T.; M. Debnath; D. HALDER

    2011-01-01

    The paper examines thoroughly all the past 23 sunspot cycles and the associated 11 hale cycles. It is noticed that solar cycle 23 had a deep minimum with longest decline phase. When solar cycles 20 to 23 are compared with solar cycles 1 to 4, the forthcoming Dalton minimum can be expected. The predicted variation of sunspot number for the present solar cycle 24 is examined at length and it appears that the peak monthly sunspot number of the solar cycle 24 will be around 80. We have correlated...

  19. Flux-tube geometry and solar wind speed during an activity cycle

    Pinto, R. F.; Brun, A. S.; Rouillard, A. P.

    2016-07-01

    Context. The solar wind speed at 1 AU shows cyclic variations in latitude and in time which reflect the evolution of the global background magnetic field during the activity cycle. It is commonly accepted that the terminal (asymptotic) wind speed in a given magnetic flux-tube is generally anti-correlated with its total expansion ratio, which motivated the definition of widely used semi-empirical scaling laws relating one to the other. In practice, such scaling laws require ad hoc corrections (especially for the slow wind in the vicinities of streamer/coronal hole boundaries) and empirical fits to in situ spacecraft data. A predictive law based solely on physical principles is still missing. Aims: We test whether the flux-tube expansion is the controlling factor of the wind speed at all phases of the cycle and at all latitudes (close to and far from streamer boundaries) using a very large sample of wind-carrying open magnetic flux-tubes. We furthermore search for additional physical parameters based on the geometry of the coronal magnetic field which have an influence on the terminal wind flow speed. Methods: We use numerical magneto-hydrodynamical simulations of the corona and wind coupled to a dynamo model to determine the properties of the coronal magnetic field and of the wind velocity (as a function of time and latitude) during a whole 11-yr activity cycle. These simulations provide a large statistical ensemble of open flux-tubes which we analyse conjointly in order to identify relations of dependence between the wind speed and geometrical parameters of the flux-tubes which are valid globally (for all latitudes and moments of the cycle). Results: Our study confirms that the terminal (asymptotic) speed of the solar wind depends very strongly on the geometry of the open magnetic flux-tubes through which it flows. The total flux-tube expansion is more clearly anti-correlated with the wind speed for fast rather than for slow wind flows, and effectively controls the

  20. Cell cycle arrest and apoptosis, two alternative mechanisms for PMKT2 killer activity.

    Santos, Antonio; Alonso, Alejandro; Belda, Ignacio; Marquina, Domingo

    2013-01-01

    Pichia membranifaciens CYC 1086 secretes a unique 30kDa killer toxin (PMKT2) that inhibits a variety of spoilage yeasts and fungi of agronomical interest. The cytocidal effect of PMKT2 on Saccharomyces cerevisiae cells was studied. Metabolic events associated with the loss of S. cerevisiae viability caused by PMKT2 were qualitatively identical to those reported for K28 killer toxin activity, but different to those reported for PMKT. At higher doses, none of the cellular events accounting for the action of PMKT, the killer toxin secreted by P. membranifaciens CYC 1106, was observed for PMKT2. Potassium leakage, sodium influx and the decrease of intracellular pH were not among the primary effects of PMKT2. We report here that this protein is unable to form ion-permeable channels in liposome membranes, suggesting that channel formation is not the mechanism of cytotoxic action of PMKT2. Nevertheless, flow cytometry studies have revealed a cell cycle arrest at an early S-phase with an immature bud and pre-replicated 1n DNA content. By testing the sensitivity of cells arrested at different stages in the cell cycle, we hoped to identify the execution point for lethality more precisely. Cells arrested at the G1-phase by α-factor or arrested at G2-phase by the spindle poison methyl benzimidazol-2-yl-carbamate (MBC) were protected against the toxin. Cells released from the arrest in both cases were killed by PMKT2 at a similar rate. Nevertheless, cells released from MBC-arrest were able to grow for a short time, and then viability dropped rapidly. These findings suggest that cells released from G2-phase are initially able to divide, but die in the presence of PMKT2 after initiating the S-phase in a new cycle, adopting a terminal phenotype within that cycle. By contrast, low doses of PMKT and PMKT2 were able to generate the same cellular response. The evidence presented here shows that treating yeast with low doses of PMKT2 leads to the typical membranous, cytoplasmic

  1. β-Arrestin biosensors reveal a rapid, receptor-dependent activation/deactivation cycle.

    Nuber, Susanne; Zabel, Ulrike; Lorenz, Kristina; Nuber, Andreas; Milligan, Graeme; Tobin, Andrew B; Lohse, Martin J; Hoffmann, Carsten

    2016-03-31

    (β-)Arrestins are important regulators of G-protein-coupled receptors (GPCRs). They bind to active, phosphorylated GPCRs and thereby shut off 'classical' signalling to G proteins, trigger internalization of GPCRs via interaction with the clathrin machinery and mediate signalling via 'non-classical' pathways. In addition to two visual arrestins that bind to rod and cone photoreceptors (termed arrestin1 and arrestin4), there are only two (non-visual) β-arrestin proteins (β-arrestin1 and β-arrestin2, also termed arrestin2 and arrestin3), which regulate hundreds of different (non-visual) GPCRs. Binding of these proteins to GPCRs usually requires the active form of the receptors plus their phosphorylation by G-protein-coupled receptor kinases (GRKs). The binding of receptors or their carboxy terminus as well as certain truncations induce active conformations of (β-)arrestins that have recently been solved by X-ray crystallography. Here we investigate both the interaction of β-arrestin with GPCRs, and the β-arrestin conformational changes in real time and in living human cells, using a series of fluorescence resonance energy transfer (FRET)-based β-arrestin2 biosensors. We observe receptor-specific patterns of conformational changes in β-arrestin2 that occur rapidly after the receptor-β-arrestin2 interaction. After agonist removal, these changes persist for longer than the direct receptor interaction. Our data indicate a rapid, receptor-type-specific, two-step binding and activation process between GPCRs and β-arrestins. They further indicate that β-arrestins remain active after dissociation from receptors, allowing them to remain at the cell surface and presumably signal independently. Thus, GPCRs trigger a rapid, receptor-specific activation/deactivation cycle of β-arrestins, which permits their active signalling. PMID:27007855

  2. A Comparison Between Global Proxies of the Sun's Magnetic Activity Cycle: Inferences from Helioseismology

    Broomhall, A -M

    2015-01-01

    The last solar minimum was, by recent standards, unusually deep and long. We are now close to the maximum of the subsequent solar cycle, which is relatively weak. In this article we make comparisons between different global (unresolved) measures of the Sun's magnetic activity, to investigate how they are responding to this weak-activity epoch. We focus on helioseismic data, which are sensitive to conditions, including the characteristics of the magnetic field, in the solar interior. Also considered are measures of the magnetic field in the photosphere (sunspot number and sunspot area), the chromosphere and corona (10.7cm radio flux and 530.3nm green coronal index), and two measures of the Sun's magnetic activity closer to Earth (the interplanetary magnetic field and the galactic cosmic-ray intensity). Scaled versions of the activity proxies diverge from the helioseismic data around 2000, indicating a change in relationship between the proxies. The degree of divergence varies from proxy to proxy with sunspot a...

  3. Thermodynamic analysis of a combined organic Rankine cycle and vapor compression cycle system activated with low temperature heat sources using low GWP fluids

    A combined organic Rankine cycle and vapor compression cycle (ORC–VCC) system activated by low temperature heat sources was studied. Two low GWP fluids were considered as working fluids for the VCC and two different low GWP fluids for the ORC. System performance was evaluated through computational modeling over different operating conditions. The computed thermal COP of the ORC–VCC system varied between 0.30 and 1.10 over the range of operating conditions studied. The computed electrical COP of the ORC–VCC system, defined as the ratio of the rate of cooling and the ORC pump power consumption, varied between 15 and 110. The choice of VCC working fluid had only a limited influence on system thermal or electrical efficiency, with HFO-1234ze(E) presenting slightly better results. Use of HFO-1336mzz(Z) as the ORC working fluid resulted in slightly higher system thermal efficiencies and significantly higher system electrical efficiencies throughout the range of operating conditions studied. Furthermore, the system is evaluated for a typical application and the feasibility study shows good economical results. - Highlights: • A combined organic Rankine cycle and vapor compression cycle system was studied. • Low GWP fluids were considered as working fluids for the VCC and for the ORC. • The computed thermal COP of the ORC–VCC system varied between 0.30 and 1.10. • The computed electrical COP of the ORC–VCC system varied between 15 and 110

  4. Flux-tube geometry and wind speed during an activity cycle

    Pinto, R F; Rouillard, A P

    2016-01-01

    The solar wind speed at 1 AU shows variations in latitude and in time which reflect the evolution of the global background magnetic field during the activity cycle. It is commonly accepted that the terminal wind speed in a magnetic flux-tube is anti-correlated with its expansion ratio, which motivated the definition of widely-used semi-empirical scaling laws relating one to the other. In practice, such scaling laws require ad-hoc corrections. A predictive law based solely on physical principles is still missing. We test whether the flux-tube expansion is the controlling factor of the wind speed at all phases of the cycle and at all latitudes using a very large sample of wind-carrying open magnetic flux-tubes. We furthermore search for additional physical parameters based on the geometry of the coronal magnetic field which have an influence on the terminal wind flow speed. We use MHD simulations of the corona and wind coupled to a dynamo model to provide a large statistical ensemble of open flux-tubes which we...

  5. The IAEA international project on innovative nuclear reactors and fuel cycles (INPRO): current and future activities

    Upon resolutions of the IAEA General Conference in 2000, the IAEA initiated International Project on Innovative Nuclear Reactors and Fuel Cycles (INPRO). The objective of INPRO, which comprises two phases, is to support sustainable deployment and use of nuclear technology to meet the global energy needs in the next 50 years and beyond. During Phase I, work is subdivided into two sub phases. Phase 1A focused on determining user requirements in the areas of economics, environment, safety, proliferation resistance, and recommendations in the area of so-called crosscutting issues, which are legal, institutional, and infrastructure issues accompanying the deployment of nuclear power, and is targeted at developing a methodology and guidelines for the assessment of various nuclear reactor and fuel cycle concepts and approaches. Phase 1A was finalised in June 2003 with its results now available as IAEA TECDOC-1362. Phase 1B has started in July 2003. During this phase interested Member States are performing case studies to validate the INPRO methodology and, later on, to assess selected innovative nuclear energy systems using the updated INPRO methodology. In accordance with the INPRO Terms of Reference, after successful completion of Phase I, Phase II may be initiated to examine the feasibility of commencing international projects on innovative nuclear energy systems. The paper contains a description of the current and future activities of INPRO and summarizes the outcome of the project.(author)

  6. Dependence of Stellar Magnetic Activity Cycles on Rotational Period in a Nonlinear Solar-type Dynamo

    Pipin, V. V.; Kosovichev, A. G.

    2016-06-01

    We study the turbulent generation of large-scale magnetic fields using nonlinear dynamo models for solar-type stars in the range of rotational periods from 14 to 30 days. Our models take into account nonlinear effects of dynamical quenching of magnetic helicity, and escape of magnetic field from the dynamo region due to magnetic buoyancy. The results show that the observed correlation between the period of rotation and the duration of activity cycles can be explained in the framework of a distributed dynamo model with a dynamical magnetic feedback acting on the turbulent generation from either magnetic buoyancy or magnetic helicity. We discuss implications of our findings for the understanding of dynamo processes operating in solar-like stars.

  7. Dependence of stellar magnetic activity cycles on rotational period in nonlinear solar-type dynamo

    Pipin, Valery

    2016-01-01

    We study turbulent generation of large-scale magnetic fields using nonlinear dynamo models for solar-type stars in the range of rotational periods from 14 to 30 days. Our models take into account non-linear effects of dynamical quenching of magnetic helicity, and escape of magnetic field from the dynamo region due to magnetic buoyancy. The results show that the observed correlation between the period of rotation and the duration of activity cycles can be explained in the framework of a distributed dynamo model with a dynamical magnetic feedback acting on the turbulent generation either from magnetic buoyancy or magnetic helicity. We discuss implications of our findings for the understanding of dynamo processes operating in solar-like stars.

  8. 14C Activity and Global Carbon Cycle Changes over the Past 50,000 Years

    Hughen, K.; Lehman, S.; Southon, J.; Overpeck, J.; Marchal, O.; Herring, C.; Turnbull, J.

    2004-01-01

    A series of 14C measurements in Ocean Drilling Program cores from the tropical Cariaco Basin, which have been correlated to the annual-layer counted chronology for the Greenland Ice Sheet Project 2 (GISP2) ice core, provides a high-resolution calibration of the radiocarbon time scale back to 50,000 years before the present. Independent radiometric dating of events correlated to GISP2 suggests that the calibration is accurate. Reconstructed 14C activities varied substantially during the last glacial period, including sharp peaks synchronous with the Laschamp and Mono Lake geomagnetic field intensity minimal and cosmogenic nuclide peaks in ice cores and marine sediments. Simulations with a geochemical box model suggest that much of the variability can be explained by geomagnetically modulated changes in 14C production rate together with plausible changes in deep-ocean ventilation and the global carbon cycle during glaciation.

  9. Metaproteogenomics reveals the soil microbial communities active in nutrient cycling processes under different tree species

    Keiblinger, Katharina Maria; Masse, Jacynthe; Zühlke, Daniela; Riedel, Katharina; Zechmeister-Boltenstern, Sophie; Prescott, Cindy E.; Grayston, Sue

    2016-04-01

    Tree species exert strong effects on microbial communities in litter and soil and may alter rates of soil processes fundamental to nutrient cycling and carbon fluxes (Prescott and Grayston 2013). However, the influence of tree species on decomposition processes are still contradictory and poorly understood. An understanding of the mechanisms underlying plant influences on soil processes is important for our ability to predict ecosystem response to altered global/environmental conditions. In order to link microbial community structure and function to forest-floor nutrient cycling processes, we sampled forest floors under western redcedar (Thuja plicata), Douglas-fir (Pseudotsuga menziesii) and Sitka spruce (Picea sitchensis) grown in nutrient-poor sites in common garden experiments on Vancouver island (Canada). We measured forest-floor total N, total C, initial NH4+ and NO3‑ concentrations, DOC, Cmic and Nmic. Gross rates of ammonification and NH4+ consumption were measured using the 15N pool-dilution method. Organic carbon quality was assessed through FTIR analyses. Microbial community structure was analysed by a metaproteogenomic approach using 16S and ITS amplification and sequencing with MiSeq platform. Proteins were extracted and peptides characterized via LC-MS/MS on a Velos Orbitrap to assess the active microbial community. Different microbial communities were active under the three tree species and variation in process rates were observed and will be discussed. This research provides new insights on microbial processes during organic matter decomposition. The metaproteogenomic approach enables us to investigate these changes with respect to possible effects on soil C-storage at even finer taxonomic resolution.

  10. IVF cycle cost estimation using Activity Based Costing and Monte Carlo simulation.

    Cassettari, Lucia; Mosca, Marco; Mosca, Roberto; Rolando, Fabio; Costa, Mauro; Pisaturo, Valerio

    2016-03-01

    The Authors present a new methodological approach in stochastic regime to determine the actual costs of an healthcare process. The paper specifically shows the application of the methodology for the determination of the cost of an Assisted reproductive technology (ART) treatment in Italy. The reason of this research comes from the fact that deterministic regime is inadequate to implement an accurate estimate of the cost of this particular treatment. In fact the durations of the different activities involved are unfixed and described by means of frequency distributions. Hence the need to determine in addition to the mean value of the cost, the interval within which it is intended to vary with a known confidence level. Consequently the cost obtained for each type of cycle investigated (in vitro fertilization and embryo transfer with or without intracytoplasmic sperm injection), shows tolerance intervals around the mean value sufficiently restricted as to make the data obtained statistically robust and therefore usable also as reference for any benchmark with other Countries. It should be noted that under a methodological point of view the approach was rigorous. In fact it was used both the technique of Activity Based Costing for determining the cost of individual activities of the process both the Monte Carlo simulation, with control of experimental error, for the construction of the tolerance intervals on the final result. PMID:24752546

  11. Solar magnetic activity cycles, coronal potential field models and eruption rates

    Petrie, G J D

    2013-01-01

    We study the evolution of the observed photospheric magnetic field and the modeled global coronal magnetic field during the past 3 1/2 solar activity cycles observed since the mid-1970s. We use synoptic magnetograms and extrapolated potential-field models based on longitudinal full-disk photospheric magnetograms from the NSO's three magnetographs at Kitt Peak, the Synoptic Optical Long-term Investigations of the Sun (SOLIS) vector spectro-magnetograph (VSM), the spectro-magnetograph and the 512-channel magnetograph instruments, and from the U. Stanford's Wilcox Solar Observatory. The associated multipole field components are used to study the dominant length scales and symmetries of the coronal field. Polar field changes are found to be well correlated with active fields over most of the period studied, except between 2003-6 when the active fields did not produce significant polar field changes. Of the axisymmetric multipoles, only the dipole and octupole follow the poles whereas the higher orders follow the ...

  12. Waves of Cdk1 Activity in S Phase Synchronize the Cell Cycle in Drosophila Embryos.

    Deneke, Victoria E; Melbinger, Anna; Vergassola, Massimo; Di Talia, Stefano

    2016-08-22

    Embryos of most metazoans undergo rapid and synchronous cell cycles following fertilization. While diffusion is too slow for synchronization of mitosis across large spatial scales, waves of Cdk1 activity represent a possible process of synchronization. However, the mechanisms regulating Cdk1 waves during embryonic development remain poorly understood. Using biosensors of Cdk1 and Chk1 activities, we dissect the regulation of Cdk1 waves in the Drosophila syncytial blastoderm. We show that Cdk1 waves are not controlled by the mitotic switch but by a double-negative feedback between Cdk1 and Chk1. Using mathematical modeling and surgical ligations, we demonstrate a fundamental distinction between S phase Cdk1 waves, which propagate as active trigger waves in an excitable medium, and mitotic Cdk1 waves, which propagate as passive phase waves. Our findings show that in Drosophila embryos, Cdk1 positive feedback serves primarily to ensure the rapid onset of mitosis, while wave propagation is regulated by S phase events. PMID:27554859

  13. A mechanistic soil biogeochemistry model with explicit representation of microbial and macrofaunal activities and nutrient cycles

    Fatichi, Simone; Manzoni, Stefano; Or, Dani; Paschalis, Athanasios

    2016-04-01

    The potential of a given ecosystem to store and release carbon is inherently linked to soil biogeochemical processes. These processes are deeply connected to the water, energy, and vegetation dynamics above and belowground. Recently, it has been advocated that a mechanistic representation of soil biogeochemistry require: (i) partitioning of soil organic carbon (SOC) pools according to their functional role; (ii) an explicit representation of microbial dynamics; (iii) coupling of carbon and nutrient cycles. While some of these components have been introduced in specialized models, they have been rarely implemented in terrestrial biosphere models and tested in real cases. In this study, we combine a new soil biogeochemistry model with an existing model of land-surface hydrology and vegetation dynamics (T&C). Specifically the soil biogeochemistry component explicitly separates different litter pools and distinguishes SOC in particulate, dissolved and mineral associated fractions. Extracellular enzymes and microbial pools are explicitly represented differentiating the functional roles of bacteria, saprotrophic and mycorrhizal fungi. Microbial activity depends on temperature, soil moisture and litter or SOC stoichiometry. The activity of macrofauna is also modeled. Nutrient dynamics include the cycles of nitrogen, phosphorous and potassium. The model accounts for feedbacks between nutrient limitations and plant growth as well as for plant stoichiometric flexibility. In turn, litter input is a function of the simulated vegetation dynamics. Root exudation and export to mycorrhiza are computed based on a nutrient uptake cost function. The combined model is tested to reproduce respiration dynamics and nitrogen cycle in few sites where data were available to test plausibility of results across a range of different metrics. For instance in a Swiss grassland ecosystem, fine root, bacteria, fungal and macrofaunal respiration account for 40%, 23%, 33% and 4% of total belowground

  14. Natural compounds' activity against cancer stem-like or fast-cycling melanoma cells.

    Malgorzata Sztiller-Sikorska

    Full Text Available BACKGROUND: Accumulating evidence supports the concept that melanoma is highly heterogeneous and sustained by a small subpopulation of melanoma stem-like cells. Those cells are considered as responsible for tumor resistance to therapies. Moreover, melanoma cells are characterized by their high phenotypic plasticity. Consequently, both melanoma stem-like cells and their more differentiated progeny must be eradicated to achieve durable cure. By reevaluating compounds in heterogeneous melanoma populations, it might be possible to select compounds with activity not only against fast-cycling cells but also against cancer stem-like cells. Natural compounds were the focus of the present study. METHODS: We analyzed 120 compounds from The Natural Products Set II to identify compounds active against melanoma populations grown in an anchorage-independent manner and enriched with cells exerting self-renewing capacity. Cell viability, cell cycle arrest, apoptosis, gene expression, clonogenic survival and label-retention were analyzed. FINDINGS: Several compounds efficiently eradicated cells with clonogenic capacity and nanaomycin A, streptonigrin and toyocamycin were effective at 0.1 µM. Other anti-clonogenic but not highly cytotoxic compounds such as bryostatin 1, siomycin A, illudin M, michellamine B and pentoxifylline markedly reduced the frequency of ABCB5 (ATP-binding cassette, sub-family B, member 5-positive cells. On the contrary, treatment with maytansine and colchicine selected for cells expressing this transporter. Maytansine, streptonigrin, toyocamycin and colchicine, even if highly cytotoxic, left a small subpopulation of slow-dividing cells unaffected. Compounds selected in the present study differentially altered the expression of melanocyte/melanoma specific microphthalmia-associated transcription factor (MITF and proto-oncogene c-MYC. CONCLUSION: Selected anti-clonogenic compounds might be further investigated as potential adjuvants

  15. North-south asymmetry in small and large sunspot group activity and violation of even-odd solar cycle rule

    Javaraiah, J

    2016-01-01

    According to Gnevyshev-Ohl (G-O) rule an odd-numbered cycle is stronger than its preceding even-numbered cycle. In the modern time the cycle pair (22, 23) violated this rule. By using the combined Greenwich Photoheliographic Results (GPR) and Solar Optical Observing Network (SOON) sunspot group data during the period 1874-2015, and Debrecen Photoheliographic Data (DPD) of sunspot groups during the period 1974-2015, here we have found that the solar cycle pair (22, 23) violated the G-O rule because, besides during cycle 23 a large deficiency of small sunspot groups in both the northern and the southern hemispheres, during cycle 22 a large abundance of small sunspot groups in the southern hemisphere. In the case of large and small sunspot groups the cycle pair (22, 23) violated the G-O rule in the northern and southern hemispheres, respectively, suggesting the north-south asymmetry in solar activity has a significant contribution in the violation of G-O rule. The amplitude of solar cycle 24 is smaller than that...

  16. Effects of Cycling Conditions of Active Material From Discharged Ni Positive Plates Studied by Inelastic Neutron Scattering Spectroscopy

    Eckert, Juergen; Varma, Ravi; Diebolt, Lisa; Reid, Margaret

    1998-01-01

    The objectives of this presentation are: identify atomic-level signatures of electrochemical activity of the active material on the Ni positive plates of Ni-H2 batteries, relate finding to cycling conditions and histories, and develop INS spectroscopy as a non-destructive testing technique for the evaluation of Ni-positive plates of Ni-H2 batteries.

  17. Role of the Epstein-Barr Virus Rta Protein in Activation of Distinct Classes of Viral Lytic Cycle Genes

    Ragoczy, Tobias; Miller, George

    1999-01-01

    Initiation of the Epstein-Barr virus (EBV) lytic cycle is controlled by two immediate-early genes, BZLF1 and BRLF1. In certain epithelial and B-cell lines, their protein products, ZEBRA and Rta, stimulate their own expression, reciprocally stimulate each other’s expression, and activate downstream viral targets. It has been difficult to examine the individual roles of these two transactivators in EBV-infected lymphocytes, as they are expressed simultaneously upon induction of the lytic cycle....

  18. Metagenome and Metatranscriptome Revealed a Highly Active Sulfur Cycle in an Oil-Immersed Hydrothermal Chimney in Guaymas Basin

    Ying eHe; Xiaoyuan eFeng; Jing eFang; Yu eZhang; Xiang eXiao

    2015-01-01

    The hydrothermal vent system is a typical chemosynthetic ecosystem in which microorganisms play essential roles in the geobiochemical cycling. Although it has been well recognized that the inorganic sulfur compounds are abundant and actively converted through chemosynthetic pathways, the sulfur budget in a hydrothermal vent is poorly characterized due to the complexity of microbial sulfur cycling resulting from the numerous parties involved in the processes. In this study, we performed an int...

  19. Household, Personal and Environmental Correlates of Rural Elderly’s Cycling Activity: Evidence from Zhongshan Metropolitan Area, China

    Yi Zhang

    2014-06-01

    Full Text Available Cycling is an important form of active transport and physical activity to provide substantial health benefits to the elderly. Among voluminous physical activity-related literature, few studies have investigated the correlates of active transport of the rural elderly in China. This study was the first attempt to investigate the impact of the household, personal, and environmental attributes on rural elderly’s cycling activity with data collected in 102 rural neighborhoods of Zhongshan Metropolitan Area, China. The negative binomial regression models suggest that, all else being equal, living in a neighborhood with low proportion of elderly population (over 60, abundant bike lanes, and a compact urban form related to high density and mixed development, are associated with the increase of frequency and duration of the rural elderly’s cycling trips. The models also detect that attitude towards cycling and household bicycle and motorized vehicle ownership are strongly related to cycling trips of the rural elderly in Zhongshan. The findings provide insights for transportation and public health agencies, practitioners, and researchers into the effective design of interventions from the prospective of attitudes, social and built environment on health promotion of the rural elderly in China.

  20. Active and long-lived permanent forearc deformation driven by the subduction seismic cycle

    Aron Melo, Felipe Alejandro

    I have used geological, geophysical and engineering methods to explore mechanisms of upper plate, brittle deformation at active forearc regions. My dissertation particularly addresses the permanent deformation style experienced by the forearc following great subduction ruptures, such as the 2010 M w8.8 Maule, Chile and 2011 Mw9.0 Tohoku, Japan earthquakes. These events triggered large, shallow seismicity on upper plate normal faults above the rupture reaching Mw7.0. First I present new structural data from the Chilean Coastal Cordillera over the rupture zone of the Maule earthquake. The study area contains the Pichilemu normal fault, which produced the large crustal aftershocks of the megathrust event. Normal faults are the major neotectonic structural elements but reverse faults also exist. Crustal seismicity and GPS surface displacements show that the forearc experiences pulses of rapid coseismic extension, parallel to the heave of the megathrust, and slow interseismic, convergence-parallel shortening. These cycles, over geologic time, build the forearc structural grain, reactivating structures properly-oriented respect to the deformation field of each stage of the interplate cycle. Great subduction events may play a fundamental role in constructing the crustal architecture of extensional forearc regions. Static mechanical models of coseismic and interseismic upper plate deformation are used to explore for distinct features that could result from brittle fracturing over the two stages of the interplate cycle. I show that the semi-elliptical outline of the first-order normal faults along the Coastal Cordillera may define the location of a characteristic, long-lived megathrust segment. Finally, using data from the Global CMT catalog I analyzed the seismic behavior through time of forearc regions that have experienced great subduction ruptures >Mw7.7 worldwide. Between 61% and 83% of the cases where upper plate earthquakes exhibited periods of increased seismicity

  1. Spirocyclic chromanes exhibit antiplasmodial activities and inhibit all intraerythrocytic life cycle stages

    Roberts, Bracken F.; Iyamu, Iredia D.; Lee, Sukjun; Lee, Eunyoung; Ayong, Lawrence; Kyle, Dennis E.; Yuan, Yu; Manetsch, Roman; Chakrabarti, Debopam

    2016-01-01

    We screened a collection of synthetic compounds consisting of natural-product-like substructural motifs to identify a spirocyclic chromane as a novel antiplasmodial pharmacophore using an unbiased cell-based assay. The most active spirocyclic compound UCF 201 exhibits a 50% effective concentration (EC50) of 350 nM against the chloroquine-resistant Dd2 strain and a selectivity over 50 using human liver HepG2 cells. Our analyses of physicochemical properties of UCF 201 showed that it is in compliance with Lipinski's parameters and has an acceptable physicochemical profile. We have performed a limited structure-activity-relationship study with commercially available chromanes preserving the spirocyclic motif. Our evaluation of stage specificities of UCF 201 indicated that the compound is early-acting in blocking parasite development at ring, trophozoite and schizont stages of development as well as merozoite invasion. SPC is an attractive lead candidate scaffold because of its ability to act on all stages of parasite's aexual life cycle unlike current antimalarials. PMID:27054067

  2. Spirocyclic chromanes exhibit antiplasmodial activities and inhibit all intraerythrocytic life cycle stages

    Bracken F. Roberts

    2016-04-01

    Full Text Available We screened a collection of synthetic compounds consisting of natural-product-like substructural motifs to identify a spirocyclic chromane as a novel antiplasmodial pharmacophore using an unbiased cell-based assay. The most active spirocyclic compound UCF 201 exhibits a 50% effective concentration (EC50 of 350 nM against the chloroquine-resistant Dd2 strain and a selectivity over 50 using human liver HepG2 cells. Our analyses of physicochemical properties of UCF 201 showed that it is in compliance with Lipinski's parameters and has an acceptable physicochemical profile. We have performed a limited structure-activity-relationship study with commercially available chromanes preserving the spirocyclic motif. Our evaluation of stage specificities of UCF 201 indicated that the compound is early-acting in blocking parasite development at ring, trophozoite and schizont stages of development as well as merozoite invasion. SPC is an attractive lead candidate scaffold because of its ability to act on all stages of parasite's aexual life cycle unlike current antimalarials.

  3. Generation of unipolar pulses in a circular Raman-active medium excited by few-cycle optical pulses

    Arkhipov, R M; Babushkin, I; Pakhomov, A V; Tolmachev, Yu A; Rosanov, N N

    2016-01-01

    We study theoretically a new possibility of unipolar pulses generation in Raman-active medium excited by a series of few-cycle optical pulses. We consider the case when the Raman-active particles are uniformly distributed along the circle, and demonstrate a possibility to obtain a unipolar rectangular video pulses with an arbitrarily long duration, ranging from a minimum value equal to the natural period of the low frequency vibrations in the Raman-active medium.

  4. Study on the Influence of Refreshment/Activation Cycles and Irrigants on Mechanical Cleaning Efficiency During Ultrasonic Activation of the Irrigant

    van der Sluis, Lucas W. M.; Vogels, Maikel P. J. M.; Verhaagen, Bram; Macedo, Ricardo; Wesselink, Paul R.

    2010-01-01

    Introduction: The aims of this study were to evaluate dentin debris removal from the root canal during ultrasonic activation of sodium hypochlorite (2% and 10%), carbonated water, and distilled water and to determine the influence of 3 ultrasonic refreshment/activation cycles of the irrigant by usin

  5. Study on the Influence of Refreshment/Activation Cycles and Irrigants on Mechanical Cleaning Efficiency During Ultrasonic Activation of the Irrigant

    Sluis, van der Lucas W.M.; Vogels, Maikel P.J.M.; Verhaagen, Bram; Macedo, Ricardo; Wesselink, Paul R.

    2010-01-01

    Introduction The aims of this study were to evaluate dentin debris removal from the root canal during ultrasonic activation of sodium hypochlorite (2% and 10%), carbonated water, and distilled water and to determine the influence of 3 ultrasonic refreshment/activation cycles of the irrigant by using

  6. Long-term variations in the geomagnetic activity level Part II: Ascending phases of sunspot cycles

    V. Mussino; O. Borello Filisetti; Storini, M.; Nevanlinna, H.

    1994-01-01

    Monthly averages of the Helsinki Ak-values have been reduced to the equivalent aa-indices to extend the aa-data set back to 1844. A periodicity of about five cycles was found for the correlation coefficient (r) between geomagnetic indices and sunspot numbers for the ascending phases of sunspot cycles 9 to 22, confirming previous findings based on a minor number of sunspot cycles. The result is useful to researchers in topics related to solar-terrestrial physics, particularly...

  7. Impact of repeated dry-wet cycles on soil greenhouse gas emissions, extracellular enzyme activity and nutrient cycling in a temperate forest

    Leitner, Sonja; Zimmermann, Michael; Bockholt, Jan; Schartner, Markus; Brugner, Paul; Holtermann, Christian; Zechmeister-Boltenstern, Sophie

    2014-05-01

    Climate change research predicts that both frequency and intensity of weather extremes such as long drought periods and heavy rainfall events will increase in mid Europe over the next decades. Soil moisture is one of the major factors controlling microbial soil processes, and it has been widely agreed that feedback effects between altered precipitation and changed soil fluxes of the greenhouse gases CO2, CH4 and N2O could intensify climate change. In a field experiment in an Austrian beech forest, we established a precipitation manipulation experiment, which will be conducted for 3 years. We use roofs to exclude rainfall from reaching the forest soil and simulate drought periods, and a sprinkler system to simulate heavy rainfall events. We applied repeated dry-wet cycles in two intensities: one treatment received 6 cycles of 1 month drought followed by 75mm irrigation within 2 hours, and a parallel treatment received 3 cycles of 2 months drought followed by 150mm irrigation within 3 hours. We took soil samples 1 day before, 1 day after and 1 week after rewetting events and analyzed them for soil nutrients and extracellular enzyme activities. Soil fluxes of CO2, N2O and CH4 were constantly monitored with an automated flux chamber system, and environmental parameters were recorded via dataloggers. In addition, we determined fluxes and nutrient concentrations of bulk precipitation, throughfall, stemflow, litter percolate and soil water. Next we plan to analyze soil microbial community composition via PLFAs to investigate microbial stress resistance and resilience, and we will use ultrasonication to measure soil aggregate stability and protection of soil organic matter in stressed and control plots. The results of the first year show that experimental rainfall manipulation has influenced soil extracellular enzymes. Potential phenoloxidase activity was significantly reduced in stressed treatments compared to control plots. All measured hydrolytic enzymes (cellulase

  8. Induction of apoptosis and antiproliferative activity of naringenin in human epidermoid carcinoma cell through ROS generation and cell cycle arrest.

    Md Sultan Ahamad

    Full Text Available A natural predominant flavanone naringenin, especially abundant in citrus fruits, has a wide range of pharmacological activities. The search for antiproliferative agents that reduce skin carcinoma is a task of great importance. The objective of this study was to analyze the anti-proliferative and apoptotic mechanism of naringenin using MTT assay, DNA fragmentation, nuclear condensation, change in mitochondrial membrane potential, cell cycle kinetics and caspase-3 as biomarkers and to investigate the ability to induce reactive oxygen species (ROS initiating apoptotic cascade in human epidermoid carcinoma A431 cells. Results showed that naringenin exposure significantly reduced the cell viability of A431 cells (p<0.01 with a concomitant increase in nuclear condensation and DNA fragmentation in a dose dependent manner. The intracellular ROS generation assay showed statistically significant (p<0.001 dose-related increment in ROS production for naringenin. It also caused naringenin-mediated epidermoid carcinoma apoptosis by inducing mitochondrial depolarization. Cell cycle study showed that naringenin induced cell cycle arrest in G0/G1 phase of cell cycle and caspase-3 analysis revealed a dose dependent increment in caspase-3 activity which led to cell apoptosis. This study confirms the efficacy of naringenin that lead to cell death in epidermoid carcinoma cells via inducing ROS generation, mitochondrial depolarization, nuclear condensation, DNA fragmentation, cell cycle arrest in G0/G1 phase and caspase-3 activation.

  9. RCC1-dependent activation of Ran accelerates cell cycle and DNA repair, inhibiting DNA damage-induced cell senescence.

    Cekan, Pavol; Hasegawa, Keisuke; Pan, Yu; Tubman, Emily; Odde, David; Chen, Jin-Qiu; Herrmann, Michelle A; Kumar, Sheetal; Kalab, Petr

    2016-04-15

    The coordination of cell cycle progression with the repair of DNA damage supports the genomic integrity of dividing cells. The function of many factors involved in DNA damage response (DDR) and the cell cycle depends on their Ran GTPase-regulated nuclear-cytoplasmic transport (NCT). The loading of Ran with GTP, which is mediated by RCC1, the guanine nucleotide exchange factor for Ran, is critical for NCT activity. However, the role of RCC1 or Ran⋅GTP in promoting cell proliferation or DDR is not clear. We show that RCC1 overexpression in normal cells increased cellular Ran⋅GTP levels and accelerated the cell cycle and DNA damage repair. As a result, normal cells overexpressing RCC1 evaded DNA damage-induced cell cycle arrest and senescence, mimicking colorectal carcinoma cells with high endogenous RCC1 levels. The RCC1-induced inhibition of senescence required Ran and exportin 1 and involved the activation of importin β-dependent nuclear import of 53BP1, a large NCT cargo. Our results indicate that changes in the activity of the Ran⋅GTP-regulated NCT modulate the rate of the cell cycle and the efficiency of DNA repair. Through the essential role of RCC1 in regulation of cellular Ran⋅GTP levels and NCT, RCC1 expression enables the proliferation of cells that sustain DNA damage. PMID:26864624

  10. CAR-mediated repression of Foxo1 transcriptional activity regulates the cell cycle inhibitor p21 in mouse livers

    Highlights: • CAR activation decreased the level of Foxo1 in mouse livers. • CAR activation decreased the level of p21 in mouse livers. • CAR activation inhibited Foxo1 transcriptional activity in mouse livers. - Abstract: 1,4-Bis[2-(3,5-dichloropyridyloxy)]benzene (TCPOBOP), an agonist of constitutive androstane receptor (CAR), is a well-known strong primary chemical mitogen for the mouse liver. Despite extensive investigation of the role of CAR in the regulation of cell proliferation, our knowledge of the intricate mediating mechanism is incomplete. In this study, we demonstrated that long-term CAR activation by TCPOBOP increased liver-to-body weight ratio and decreased tumour suppressor Foxo1 expression and transcriptional activity, which were correlated with reduced expression of genes regulated by Foxo1, including the cell-cycle inhibitor Cdkn1a(p21), and upregulation of the cell-cycle regulator Cyclin D1. Moreover, we demonstrated the negative regulatory effect of TCPOBOP-activated CAR on the association of Foxo1 with the target Foxo1 itself and Cdkn1a(p21) promoters. Thus, we identified CAR-mediated repression of cell cycle inhibitor p21, as mediated by repression of FOXO1 expression and transcriptional activity. CAR-FOXO1 cross-talk may provide new opportunities for understanding liver diseases and developing more effective therapeutic approaches to better drug treatments

  11. The spatial relationship between active regions and coronal holes and the occurrence of intense geomagnetic storms throughout the solar activity cycle

    S. Bravo

    Full Text Available We study the annual frequency of occurrence of intense geomagnetic storms (Dst < –100 nT throughout the solar activity cycle for the last three cycles and find that it shows different structures. In cycles 20 and 22 it peaks during the ascending phase, near sunspot maximum. During cycle 21, however, there is one peak in the ascending phase and a second, higher, peak in the descending phase separated by a minimum of storm occurrence during 1980, the sunspot maximum. We compare the solar cycle distribution of storms with the corresponding evolution of coronal mass ejections and flares. We find that, as the frequency of occurrence of coronal mass ejections seems to follow very closely the evolution of the sunspot number, it does not reproduce the storm profiles. The temporal distribution of flares varies from that of sunspots and is more in agreement with the distribution of intense geomagnetic storms, but flares show a maximum at every sunspot maximum and cannot then explain the small number of intense storms in 1980. In a previous study we demonstrated that, in most cases, the occurrence of intense geomagnetic storms is associated with a flaring event in an active region located near a coronal hole. In this work we study the spatial relationship between active regions and coronal holes for solar cycles 21 and 22 and find that it also shows different temporal evolution in each cycle in accordance with the occurrence of strong geomagnetic storms; although there were many active regions during 1980, most of the time they were far from coronal holes. We analyse in detail the situation for the intense geomagnetic storms in 1980 and show that, in every case, they were associated with a flare in one of the few active regions adjacent to a coronal hole.

  12. Behavior of Jatropha curcas L. seeds under osmotic stress: germination and cell cycle activity

    Cristiane Dantas de Brito

    2015-08-01

    Full Text Available Jatropha curcas is an oil-rich Euphorbiaceae seed species renowned for its apparent tolerance to environmental stresses. It is considered a promising source of renewable feedstock for biodiesel production in the Brazilian semiarid region where crop establishment requires a better understanding of the mechanisms leading to proper seed and plant behavior under water restrictive conditions. This study describes physiological and cytological profiles of J. curcas seeds imbibed in water restriction conditions by means of osmotic stress or osmoconditioning. Seeds were characterized by size, weight, moisture content and dry mass, germinability, and cell cycle activation by means of tubulin and microtubule cytoskeleton accumulation. Osmoconditioning at -0.8 MPa did not induce priming effects as it did not improve the physiological quality of the seed lots. Western blotting and immunocytochemical analysis revealed an increasing accumulation of tubulin and microtubule cytoskeleton in seeds imbibed in water for 48h onwards, culminating in the onset of mitotic configurations after germination. Only cortical microtubules were observed during seed osmoconditioning, whereas mitotic microtubules only occurred after re-imbibition of osmoconditioned seeds in water and subsequent germination.

  13. A Statistical Analysis of Solar Surface Indices Through the Solar Activity Cycles 21-23

    Goker, Umit Deniz; Nutku, Ferhat; Priyal, Muthu

    2016-01-01

    Variations of total solar irradiance (TSI), magnetic field, Ca II K-flux, faculae and plage areas due to the number and the type of sunspots/sunspot groups (SGs) are well established by using ground based data from various centers such as Solar Irradiance Platform, Stanford Data (SFO), Kodaikanal data (KKL) and National Geographical Data Center (NGDC) Homepage, respectively. We applied time series analysis for extracting the data over the descending phases of solar activity cycles (SACs) 21, 22 and 23, and the ascending phases 22 and 23 of SACs, and analyzed the selected data using the Python programming language. Our detailed analysis results suggest that there is a stronger correlation between solar surface indices and the changes in the relative portion of the small and large SGs. This somewhat unexpected finding suggest that plage regions decreased in a lower values in spite of the higher number of large SGs in SAC 23 while Ca II K-flux did not decrease by large amount or it was comparable with SAC 22 for...

  14. TOUSLED Kinase Activity Oscillates during the Cell Cycle and Interacts with Chromatin Regulators1

    Ehsan, Hashimul; Reichheld, Jean-Philippe; Durfee, Tim; Roe, Judith L.

    2004-01-01

    The TOUSLED (TSL)-like nuclear protein kinase family is highly conserved in plants and animals. tsl loss of function mutations cause pleiotropic defects in both leaf and flower development, and growth and initiation of floral organ primordia is abnormal, suggesting that basic cellular processes are affected. TSL is more highly expressed in exponentially growing Arabidopsis culture cells than in stationary, nondividing cells. While its expression remains constant throughout the cell cycle in dividing cells, TSL kinase activity is higher in enriched late G2/M-phase and G1-phase populations of Arabidopsis suspension culture cells compared to those in S-phase. tsl mutants also display an aberrant pattern and increased expression levels of the mitotic cyclin gene CycB1;1, suggesting that TSL represses CycB1;1 expression at certain times during development or that cells are delayed in mitosis. TSL interacts with and phosphorylates one of two Arabidopsis homologs of the nucleosome assembly/silencing protein Asf1 and histone H3, as in humans, and a novel plant SANT/myb-domain protein, TKI1, suggesting that TSL plays a role in chromatin metabolism. PMID:15047893

  15. Sprainting activity of captive otters: its relationship with breeding cycle and number of animals

    Claudio Prigioni

    1995-12-01

    Full Text Available Abstract The marking activity of captive otters (Lutra lutra was studied from April 1989 to August 1993 in an enclosure of 1.64 ha in size, located in the Ticino Valley Natural Park (Piemonte region, northern Italy. The number of otters in the enclosure varied from 1 to 6 and three litters of 1, 2 and 2 cubs were recorded in October 1990, 1991 and 1992. The sprainting activity, expressed as number of signs (spraints and anal secretions per day was associated to the breeding cycle and increased in relation to the number of animals present in the enclosure. These data are of particular importance in order to explain the annual variation of the marking level in wild otter populations. Riassunto Attività di marcamento di 1ontre in cattività in relazione a1 ciclo riproduttivo e a1 numero degli animali - L'attività di marcamento della lontra (Lutra lutra è stata rilevata dall'aprile 1989 all'agosto 1993 in un recinto di 1,64 ha, situato nel Parco Naturale della Valle del Ticino (regione Piemonte, provincia di Novara. I1 numero di animali presenti in tale recinto variava da 1 a 6, e la nascita di tre cucciolate, composte da 1, 2 e 2 piccoli, è stata registrata in ottobre negli anni 1990, 1991 e 1992. L'intensità di marcamento, espressa come numero di segni (feci e secrezioni anali per giorno era associata a1 ciclo riproduttivo della specie e incrementava in relazione al numero di animali presenti nel recinto. I dati acquisiti rivestono particolare importanza per interpretare le variazioni nell'arco dell'anno del livello di marcamento di popolazioni selvatiche.

  16. Effectiveness and student perceptions of an active learning activity using a headline news story to enhance in-class learning of cell cycle regulation.

    Dirks-Naylor, Amie J

    2016-06-01

    An active learning activity was used to engage students and enhance in-class learning of cell cycle regulation in a PharmD level integrated biological sciences course. The aim of the present study was to determine the effectiveness and perception of the in-class activity. After completion of a lecture on the topic of cell cycle regulation, students completed a 10-question multiple-choice quiz before and after engaging in the activity. The activity involved reading of a headline news article published by ScienceDaily.com entitled "One Gene Lost Equals One limb Regained." The name of the gene was deleted from the article and, thus, the end goal of the activity was to determine the gene of interest by the description in the story. The activity included compiling a list of all potential gene candidates before sufficient information was given to identify the gene of interest (p21). A survey was completed to determine student perceptions of the activity. Quiz scores improved by an average of 20% after the activity (40.1 ± 1.95 vs. 59.9 ± 2.14,Pactivity, found the news article interesting, and believed that the activity improved their understanding of cell cycle regulation. The majority of students agreed that the in-class activity piqued their interest for learning the subject matter and also agreed that if they understand a concept during class, they are more likely to want to study that concept outside of class. In conclusion, the activity improved in-class understanding and enhanced interest in cell cycle regulation. PMID:27068993

  17. Results of active cycle of breathing techniques and conventional physiotherapy in mucociliary clearance in children with cystic fibrosis

    Hristara-Papadopoulou, A; Tsanakas, J

    2007-01-01

    Aim: The aim of the present study is the comparison of the results of the appliance of two methods of respiratory physiotherapy; the active cycle of breathing techniques in drainage positions and the conventional physiotherapy, regarding their effects on mucociliary clearance in patients with cystic fibrosis.

  18. Endo- and exocytic rate constants for spontaneous and protein kinase C-activated T cell receptor cycling

    Menné, Charlotte; Møller Sørensen, Tine; Siersma, Volkert;

    2002-01-01

    constant of the TCR was low (approximately 0.012 min(-1)) whereas the spontaneous exocytic rate constant was similar to that of other cycling receptors (approximately 0.055 min(-1)). Following protein kinase C activation (PKC) the endocytic rate constant was increased tenfold (to approximately 0.128 min(-1...

  19. To Tan or Not to Tan?: Students Learn About Sunscreens through an Inquiry Activity Based on the Learning Cycle

    Keen-Rocha, Linda

    2005-01-01

    Science instructors sometimes avoid inquiry-based activities due to limited classroom time. Inquiry takes time, as students choose problems, design experiments, obtain materials, conduct investigations, gather data, communicate results, and discuss their experiments. While there are no quick solutions to time concerns, the 5E learning cycle seeks…

  20. Fuel-Stimulated Insulin Secretion Depends upon Mitochondria Activation and the Integration of Mitochondrial and Cytosolic Substrate Cycles

    Gary W Cline

    2011-01-01

    The pancreatic islet β-cell is uniquely specialized to couple its metabolism and rates of insulin secretion with the levels of circulating nutrient fuels, with the mitochondrial playing a central regulatory role in this process. In the β-cell, mitochondrial activation generates an integrated signal reflecting rates of oxidativephosphorylation, Kreb's cycle flux, and anaplerosis that ultimately determines the rate of insulin exocytosis. Mitochondrial activation can be regulated by proton leak ...

  1. Environmental physiology: effects of energy-related pollutants on daily cycles of energy metabolism, motor activity, and thermoregulation

    This section contains a summary of research on the effects of energy-related pollutants on daily cycles of energy metabolism, motor activity, and thermoregulation. So far, mice have been exposed to fast neutron-gamma radiation or to the chemical effluents of an atmospheric pressure experimental fluidized-bed combustor. The physiological parameters measured included: O2 consumption; CO2 production; motor activity; and deep body temperatures

  2. Representing active travel: a formative evaluation of a computer visualisation tool demonstrating a new walking and cycling route

    Bill, Emma; Baker, Graham; Ferguson, Neil S.; Drinkwater, David; Mutrie, Nanette

    2015-01-01

    Transport and public health researchers have a shared interest in the promotionof active travel. Walking and cycling are activities that may help to achieve healthbenefits while also contributing to wider sustainability goals, such as a reduction in carbon emissions from transport, improvements in air quality, and reduced congestion. A variety of interventions have been used to promote travel behaviour change, for example, infrastructure change and personalised travel planning. Some researche...

  3. Repression of c-Myc responsive genes in cycling cells causes G1 arrest through reduction of cyclin E/CDK2 kinase activity

    Berns, K.; Hijmans, E.M.; Bernards, R.A.

    1997-01-01

    The c-myc gene encodes a sequence-specific DNA binding protein involved in proliferation and oncogenesis. Activation of c-myc expression in quiescent cells is sufficient to mediate cell cycle entry, whereas inhibition of c-myc expression causes cycling cells to withdraw from the cell cycle. To searc

  4. The Epstein-Barr Virus Rta Protein Activates Lytic Cycle Genes and Can Disrupt Latency in B Lymphocytes

    Ragoczy, Tobias; Heston, Lee; Miller, George

    1998-01-01

    The transition of Epstein-Barr virus (EBV) from latency into the lytic cycle is associated with the expression of two immediate-early viral genes, BZLF1 and BRLF1. Overexpression of ZEBRA, the product of BZLF1, is sufficient to disrupt latency in B lymphocytes and epithelial cells by stimulating expression of lytic cycle genes, including BRLF1. The BRLF1 product Rta functions as a transcriptional activator in both B lymphocytes and epithelial cells. However, Rta has recently been reported to ...

  5. Environmental impact associated with activated carbon preparation from olive-waste cake via life cycle assessment.

    Hjaila, K; Baccar, R; Sarrà, M; Gasol, C M; Blánquez, P

    2013-11-30

    The life cycle assessment (LCA) environmental tool was implemented to quantify the potential environmental impacts associated with the activated carbon (AC) production process from olive-waste cakes in Tunisia. On the basis of laboratory investigations for AC preparation, a flowchart was developed and the environmental impacts were determined. The LCA functional unit chosen was the production of 1 kg of AC from by-product olive-waste cakes. The results showed that impregnation using H3PO4 presented the highest environmental impacts for the majority of the indicators tested: acidification potential (62%), eutrophication (96%), ozone depletion potential (44%), human toxicity (64%), fresh water aquatic ecotoxicity (90%) and terrestrial ecotoxicity (92%). One of the highest impacts was found to be the global warming potential (11.096 kg CO2 eq/kg AC), which was equally weighted between the steps involving impregnation, pyrolysis, and drying the washed AC. The cumulative energy demand of the AC production process from the by-product olive-waste cakes was 167.63 MJ contributed by impregnation, pyrolysis, and drying the washed AC steps. The use of phosphoric acid and electricity in the AC production were the main factors responsible for the majority of the impacts. If certain modifications are incorporated into the AC production, such as implementing synthesis gas recovery and reusing it as an energy source and recovery of phosphoric acid after AC washing, additional savings could be realized, and environmental impacts could be minimized. PMID:24091159

  6. Influence of Cell Cycle and Oncogene Activity upon Topoisomerase IIα Expression and Drug Toxicity

    Stacey, Dennis W.; Hitomi, Masahiro; Chen, Guan

    2000-01-01

    The cell cycle, oncogenic signaling, and topoisomerase (topo) IIα levels all influence sensitivity to anti-topo II drugs. Because the cell cycle and oncogenic signaling influence each other as well as topo IIα levels, it is difficult to assess the importance of any one of these factors independently of the others during drug treatment. Such information, however, is vital to an understanding of the cellular basis of drug toxicity. We, therefore, developed a series of analytical procedures to i...

  7. Deciphering solar magnetic activity. I. On the relationship between the sunspot cycle and the evolution of small magnetic features

    Sunspots are a canonical marker of the Sun's internal magnetic field which flips polarity every ∼22 yr. The principal variation of sunspots, an ∼11 yr variation, modulates the amount of the magnetic field that pierces the solar surface and drives significant variations in our star's radiative, particulate, and eruptive output over that period. This paper presents observations from the Solar and Heliospheric Observatory and Solar Dynamics Observatory indicating that the 11 yr sunspot variation is intrinsically tied to the spatio-temporal overlap of the activity bands belonging to the 22 yr magnetic activity cycle. Using a systematic analysis of ubiquitous coronal brightpoints and the magnetic scale on which they appear to form, we show that the landmarks of sunspot cycle 23 can be explained by considering the evolution and interaction of the overlapping activity bands of the longer-scale variability.

  8. Inhibition of protein kinase B activity induces cell cycle arrest and apoptosis during early G₁ phase in CHO cells.

    van Opstal, Angélique; Bijvelt, José; van Donselaar, Elly; Humbel, Bruno M; Boonstra, Johannes

    2012-04-01

    Inhibition of PKB (protein kinase B) activity using a highly selective PKB inhibitor resulted in inhibition of cell cycle progression only if cells were in early G1 phase at the time of addition of the inhibitor, as demonstrated by time-lapse cinematography. Addition of the inhibitor during mitosis up to 2 h after mitosis resulted in arrest of the cells in early G1 phase, as deduced from the expression of cyclins D and A and incorporation of thymidine. After 24 h of cell cycle arrest, cells expressed the cleaved caspase-3, a central mediator of apoptosis. These results demonstrate that PKB activity in early G1 phase is required to prevent the induction of apoptosis. Using antibodies, it was demonstrated that active PKB translocates to the nucleus during early G1 phase, while an even distribution of PKB was observed through cytoplasm and nucleus during the end of G1 phase. PMID:22251027

  9. Global Climate Modeling of the Martian water cycle with improved microphysics and radiatively active water ice clouds

    Navarro, Thomas; Forget, François; Spiga, Aymeric; Millour, Ehouarn; Montmessin, Franck

    2013-01-01

    Radiative effects of water ice clouds have noteworthy consequences on the Martian atmosphere, its thermal structure and circulation. Accordingly, the inclusion of such effects in the LMD Mars Global Climate Model (GCM) greatly modifies the simulated Martian water cycle. The intent of this paper is to address the impact of radiatively active clouds on atmospheric water vapor and ice in the GCM and improve its representation. We propose a new enhanced modeling of the water cycle, consisting of detailed cloud microphysics with dynamic condensation nuclei and a better implementation of perennial surface water ice. This physical modeling is based on tunable parameters. This new version of the GCM is compared to the Thermal Emission Spectrometer observations of the water cycle. Satisfying results are reached for both vapor and cloud opacities. However, simulations yield a lack of water vapor in the tropics after Ls=180{\\deg} which is persistent in simulations compared to observations, as a consequence of aphelion c...

  10. Discovery of an activity cycle in the solar-analog HD 45184. Exploring Balmer and metallic lines as activity proxy candidates

    Flores, M; Arancibia, M Jaque; Buccino, A; Saffe, C

    2016-01-01

    (Abridged) Most stellar activity cycles similar to that found in the Sun have been detected by using the chromospheric Ca II H&K lines as stellar activity proxies. However, it is unclear if such activity cycles could be identified using other optical lines. Aims. To detect activity cycles in solar-analog stars and determine if these can be identified through other optical lines, such as Fe II and Balmer lines. We study the solar-analog star HD 45184. Methods. We analyse the activity signatures of HD 45184 by using 291 HARPS spectra obtained between 2003 and 2014. In order to search for line-core fluxes variations, we focus on Ca II H&K and Balmer H$\\alpha$, H$\\beta$ lines, which are usually used as optical chromospheric activity indicators. We calculate the HARPS-S index from Ca II H&K lines and convert it to the Mount-Wilson scale. In addition, we also consider as activity indicators the equivalent widths of Balmer lines. Moreover, we analyse the possible variability of Fe II and other metallic l...

  11. Near-earth solar wind flows and related geomagnetic activity during more than four solar cycles (1963–2011

    Richardson Ian G.

    2012-05-01

    Full Text Available In past studies, we classified the near-Earth solar wind into three basic flow types based on inspection of solar wind plasma and magnetic field parameters in the OMNI database and additional data (e.g., geomagnetic indices, energetic particle, and cosmic ray observations. These flow types are: (1 High-speed streams associated with coronal holes at the Sun, (2 Slow, interstream solar wind, and (3 Transient flows originating with coronal mass ejections at the Sun, including interplanetary coronal mass ejections and the associated upstream shocks and post-shock regions. The solar wind classification in these previous studies commenced with observations in 1972. In the present study, as well as updating this classification to the end of 2011, we have extended the classification back to 1963, the beginning of near-Earth solar wind observations, thereby encompassing the complete solar cycles 20 to 23 and the ascending phase of cycle 24. We discuss the cycle-to-cycle variations in near-Earth solar wind structures and the related geomagnetic activity over more than four solar cycles, updating some of the results of our earlier studies.

  12. Near-Earth Solar Wind Flows and Related Geomagnetic Activity During more than Four Solar Cycles (1963-2011)

    Richardson, Ian G.; Cane, Hilary V.

    2012-01-01

    In past studies, we classified the near-Earth solar wind into three basic flow types based on inspection of solar wind plasma and magnetic field parameters in the OMNI database and additional data (e.g., geomagnetic indices, energetic particle, and cosmic ray observations). These flow types are: (1) High-speed streams associated with coronal holes at the Sun, (2) Slow, interstream solar wind, and (3) Transient flows originating with coronal mass ejections at the Sun, including interplanetary coronal mass ejections and the associated upstream shocks and post-shock regions. The solar wind classification in these previous studies commenced with observations in 1972. In the present study, as well as updating this classification to the end of 2011, we have extended the classification back to 1963, the beginning of near-Earth solar wind observations, thereby encompassing the complete solar cycles 20 to 23 and the ascending phase of cycle 24. We discuss the cycle-to-cycle variations in near-Earth solar wind structures and l1e related geomagnetic activity over more than four solar cycles, updating some of the results of our earlier studies.

  13. CO{sub 2} looping cycle performance of a high-purity limestone after thermal activation/doping

    Vasilije Manovic; Edward J. Anthony; Gemma Grasa; J. Carlos Abanades [CANMET Energy Technology Centre Ottawa, Ottawa, ON (Canada)

    2008-09-15

    The influence of thermal pretreatment on the performance of a high-purity limestone (La Blanca) during CO{sub 2} capture cycles is investigated in this paper. This limestone was chosen for more detailed investigation because, in earlier research, it failed to show any favorable effect as a result of thermal pretreatment. Here, the original sample, with a particle size of 0.4-0.6 mm, and ground samples were thermally pretreated at 1000-1200{sup o}C, for 6-24 h, and then subjected to several carbonation/calcination cycles in a thermogravimetric analyzer (TGA). This work shows that thermal pretreatment failed to produce a significant self-reactivation effect during CO{sub 2} cycles, despite the use of a wide range of conditions during pretreatment (grinding, temperature, and pretreatment duration) as well as during cycling (CO{sub 2} concentration and duration of the carbonation stage). Additional doping experiments showed that both high Na content and lack of Al in La Blanca limestone cause poor self-reactivation performance after thermal pretreatment. Scanning electron microscope-energy-dispersive X-ray (SEM-EDX) analyses also confirmed more pronounced sintering and loss of activity, which we believe are caused by the relatively high Na content. However, stabilization of sorbent particle morphology by Al can allow this limestone to show self-reactivation performance and higher conversions over a longer series of CO{sub 2} cycles. 35 refs., 12 figs., 2 tabs.

  14. High Erk activity suppresses expression of the cell cycle inhibitor p27Kip1 in colorectal cancer cells

    Raabe Thomas

    2010-02-01

    Full Text Available Abstract The molecular heterogeneity of human cancer cells at the level of signaling protein activities remains poorly understood. Using a panel of 64 colorectal (CRC cancer cell lines the activity status of the MAP kinases Erk1 and Erk2 was investigated. Erk1/2 activity varied greatly within the CRC cell line panel and was not detectably associated with the speed of cell growth in 10 CRC lines analyzed. As expected, mutations in K-Ras or B-Raf were often, albeit not always, linked to high Erk1/2 activity. The phosphorylation of several known Erk1/2 targets investigated did not generally reflect Erk1/2 activity in the 10 CRC lines analyzed. However, the reduction of Erk1/2 activity with MEK inhibitors generally abolished cell growth but only led to an increase of cellular p27Kip1 levels in CRC cells with high Erk1/2 activity levels. The results indicate that high Erk1/2 activation is utilized by some CRC lines to override the cell cycle brake p27Kip1, while others presumably rely on different mechanisms in order to inactivate this important cell cycle brake. Such detailed knowledge of the molecular diversity of cancer cell signaling mechanisms may eventually help to develop molecularly targeted, patient-specific therapeutic strategies and treatments.

  15. Identification and analysis of slip systems activated during low-cycle fatigue in a duplex stainless steel

    El Bartali, A.; Aubin, V.; Sabatier, L. [Laboratoire de Mecanique de Lille, LML, UMR CNRS 8107, Ecole Centrale de Lille, BP 48, 59651 Villeneuve d' Ascq Cedex (France); Villechaise, P. [Laboratoire de Mecanique et de Physique des Materiaux, LMPM, UMR CNRS 6617, Ecole Nationale Superieure de Mecanique et Aerotechnique, Teleport 2, 1 Avenue C. Ader, BP 40109, 86961 Futuroscope, Chasseneuil Cedex (France); Degallaix-Moreuil, S. [Laboratoire de Mecanique de Lille, LML, UMR CNRS 8107, Ecole Centrale de Lille, BP 48, 59651 Villeneuve d' Ascq Cedex (France)], E-mail: suzanne.degallaix@ec-lille.fr

    2008-12-15

    This paper focuses on the identification of activated slip systems in low-cycle fatigue ({delta}{epsilon}{sub t}/2 = 5 x 10{sup -3}) in a duplex stainless steel. From electron backscattered diffraction measurements and scanning electron microscopy observations, the slip systems and their associated Schmid factor are analyzed in both constitutive phases. In austenitic grains, one or two slip systems are activated with Schmid factors greater than 0.25. While in the ferritic grains, several slip systems are activated, with a variety of Schmid factors.

  16. Identification and analysis of slip systems activated during low-cycle fatigue in a duplex stainless steel

    This paper focuses on the identification of activated slip systems in low-cycle fatigue (Δεt/2 = 5 x 10-3) in a duplex stainless steel. From electron backscattered diffraction measurements and scanning electron microscopy observations, the slip systems and their associated Schmid factor are analyzed in both constitutive phases. In austenitic grains, one or two slip systems are activated with Schmid factors greater than 0.25. While in the ferritic grains, several slip systems are activated, with a variety of Schmid factors

  17. North-south asymmetry in solar activity: predicting the amplitude of the next solar cycle

    Javaraiah, J

    2007-01-01

    Using Greenwich and SOON sunspot group data during the period 1874 -- 2005, we find that the sums of the areas of the sunspot groups in $0^\\circ$ -- $10^\\circ$ latitude-interval of the Sun's northern hemisphere and in the time-interval, minus 1.35 year to plus 2.15 year from the time of the preceding minimum--and in the same latitude interval of the southern hemisphere but plus 1.0 year to plus 1.75 year from the time of the maximum--of a sunspot cycle are well correlating with the amplitude (maximum of the smoothed monthly sunspot number) of its immediate following cycle. Using this relationship it is possible to predict the amplitude of a sunspot cycle by about 9 -- 13 years in advance. We predicted $74 \\pm 10$ for the amplitude of the upcoming cycle~24. Variations in solar meridional flows during solar cycles and 9 -- 16 year variations in solar equatorial rotation may be responsible for the aforementioned relationship.

  18. Fuel-Stimulated Insulin Secretion Depends upon Mitochondria Activation and the Integration of Mitochondrial and Cytosolic Substrate Cycles

    Gary W. Cline

    2011-10-01

    Full Text Available The pancreatic islet β-cell is uniquely specialized to couple its metabolism and rates of insulin secretion with the levels of circulating nutrient fuels, with the mitochondrial playing a central regulatory role in this process. In the β-cell, mitochondrial activation generates an integrated signal reflecting rates of oxidativephosphorylation, Kreb's cycle flux, and anaplerosis that ultimately determines the rate of insulin exocytosis. Mitochondrial activation can be regulated by proton leak and mediated by UCP2, and by alkalinization to utilize the pH gradient to drive substrate and ion transport. Converging lines of evidence support the hypothesis that substrate cycles driven by rates of Kreb's cycle flux and by anaplerosis play an integral role in coupling responsive changes in mitochondrial metabolism with insulin secretion. The components and mechanisms that account for the integrated signal of ATP production, substrate cycling, the regulation of cellular redox state, and the production of other secondary signaling intermediates are operative in both rodent and human islet β-cells.

  19. The evolution of activity breaks in the nest cycle of annual eusocial bees: a model of delayed exponential growth

    Strohm Erhard

    2006-06-01

    Full Text Available Abstract Background Social insects show considerable variability not only in social organisation but also in the temporal pattern of nest cycles. In annual eusocial sweat bees, nest cycles typically consist of a sequence of distinct phases of activity (queen or workers collect food, construct, and provision brood cells and inactivity (nest is closed. Since the flight season is limited to the time of the year with sufficiently high temperatures and resource availability, every break reduces the potential for foraging and, thus, the productivity of a colony. This apparent waste of time has not gained much attention. Results We present a model that explains the evolution of activity breaks by assuming differential mortality during active and inactive phases and a limited rate of development of larvae, both reasonable assumptions. The model predicts a systematic temporal structure of breaks at certain times in the season which increase the fitness of a colony. The predicted pattern of these breaks is in excellent accordance with field data on the nest cycle of the halictid Lasioglossum malachurum. Conclusion Activity breaks are a counter-intuitive outcome of varying mortality rates that maximise the reproductive output of primitively eusocial nests.

  20. Overview of the International R&D Recycling Activities of the Nuclear Fuel Cycle

    Patricia Paviet-Hartmann

    2012-10-01

    Nuclear power has demonstrated over the last 30 years its capacity to produce base-load electricity at a low, predictable and stable cost due to the very low economic dependence on the price of uranium. However the management of used nuclear fuel remains the “Achilles’ Heel” of this energy source since the storage of used nuclear fuel is increasing as evidenced by the following number with 2,000 tons of UNF produced each year by the 104 US nuclear reactor units which equates to a total of 62,000 spent fuel assemblies stored in dry cask and 88,000 stored in pools. Two options adopted by several countries will be presented. The first one adopted by Europe, Japan and Russia consists of recycling the used nuclear fuel after irradiation in a nuclear reactor. Ninety six percent of uranium and plutonium contained in the spent fuel could be reused to produce electricity and are worth recycling. The separation of uranium and plutonium from the wastes is realized through the industrial PUREX process so that they can be recycled for re-use in a nuclear reactor as a mixed oxide (MOX) fuel. The second option undertaken by Finland, Sweden and the United States implies the direct disposal of used nuclear fuel into a geologic formation. One has to remind that only 30% of the worldwide used nuclear fuel are currently recycled, the larger part being stored (90% in pool) waiting for scientific or political decisions. A third option is emerging with a closed fuel cycle which will improve the global sustainability of nuclear energy. This option will not only decrease the volume amount of nuclear waste but also the long-term radiotoxicity of the final waste, as well as improving the long-term safety and the heat-loading of the final repository. At the present time, numerous countries are focusing on the R&D recycling activities of the ultimate waste composed of fission products and minor actinides (americium and curium). Several new chemical extraction processes, such as TRUSPEAK

  1. Overview of the international R and D recycling activities of the nuclear fuel cycle

    Nuclear power has demonstrated over the last thirty years its capacity to produce base-load electricity at a low, predictable and stable cost due to the very low economic dependence of the price of uranium. However the management of used nuclear fuel (UNF) remains the “Achilles’ heel of this energy source since the storage of UNF is increasing as evidenced by the following number with 2,000 to 2,300 of UNF produced each year by the 104 US nuclear reactor units which equates to a total of 62,000 UNF assemblies stored in dry cask storage and 88,000 stored in pools. Alarmingly, more than half of US commercial reactor sites have filled their pools to capacity and have had to add dry cask storage facilities. Two options adopted by several countries will be discussed. The first one adopted by Europe, Japan and Russia consists of recycling the used nuclear fuel after irradiation in a nuclear reactor. Ninety six percent of uranium and plutonium contained in the spent fuel could be reused to produce electricity and are worth recycling. The separation of uranium and plutonium from the wastes is realized through the industrial PUREX process so that they can be recycled for re-use in a nuclear reactor as a mixed oxide (MOX) fuel. The second option undertaken by Finland, Sweden and the United States implies the direct disposal of UNF into a geologic formation. One has to remind that only 30% of the worldwide UNF are currently recycled, the larger part being stored (90% in pool) waiting for scientific or political decisions. A third option is emerging with a closed fuel cycle which will improve the global sustainability of nuclear energy. This option will not only decrease the volume amount of nuclear waste but also the long-term radiotoxicity of the final waste, as well as improving the long-term safety and the heat-loading of the final repository. At the present time, numerous countries are focusing on the R and D recycling activities of the ultimate waste composed of

  2. A new solar signal: Average maximum sunspot magnetic fields independent of activity cycle

    Livingston, William

    2016-01-01

    Over the past five years, 2010-2015, we have observed, in the near infrared (IR), the maximum magnetic field strengths for 4145 sunspot umbrae. Herein we distinguish field strengths from field flux. (Most solar magnetographs measure flux). Maximum field strength in umbrae is co-spatial with the position of umbral minimum brightness (Norton and Gilman, 2004). We measure field strength by the Zeeman splitting of the Fe 15648.5 A spectral line. We show that in the IR no cycle dependence on average maximum field strength (2050 G) has been found +/- 20 Gauss. A similar analysis of 17,450 spots observed by the Helioseismic and Magnetic Imager onboard the Solar Dynamics Observatory reveal the same cycle independence +/- 0.18 G., or a variance of 0.01%. This is found not to change over the ongoing 2010-2015 minimum to maximum cycle. Conclude the average maximum umbral fields on the Sun are constant with time.

  3. On the possible relations between solar activities and global seismicity in the solar cycle 20 to 23

    Herdiwijaya, Dhani, E-mail: dhani@as.itb.ac.id [Astronomy Research Division and Bosscha Observatory, Faculty of Mathematics and Natural Sciences, Bandung Institute of Technology, Ganesha 10, Bandung, Indonesia 40132 (Indonesia); Arif, Johan [Geology Research Division, Faculty of Earth Sciences and Technology, Bandung Institute of Technology, Ganesha 10, Bandung, Indonesia 40132 (Indonesia); Nurzaman, Muhamad Zamzam; Astuti, Isna Kusuma Dewi [Astronomy Study Program, Faculty of Mathematics and Natural Sciences, Bandung Institute of Technology, Ganesha 10, Bandung, Indonesia 40132 (Indonesia)

    2015-09-30

    Solar activities consist of high energetic particle streams, electromagnetic radiation, magnetic and orbital gravitational forces. The well-know solar activity main indicator is the existence of sunspot which has mean variation in 11 years, named by solar cycle, allow for the above fluctuations. Solar activities are also related to the space weather affecting all planetary atmospheric variability, moreover to the Earth’s climate variability. Large extreme space and geophysical events (high magnitude earthquakes, explosive volcanic eruptions, magnetic storms, etc.) are hazards for humankind, infrastructure, economies, technology and the activities of civilization. With a growing world population, and with modern reliance on delicate technological systems, human society is becoming increasingly vulnerable to natural hazardous events. The big question arises to the relation between solar forcing energy to the Earth’s global seismic activities. Estimates are needed for the long term occurrence-rate probabilities of these extreme natural hazardous events. We studied connectivity from yearly seismic activities that refer to and sunspot number within the solar cycle 20 to 23 of year 1960 to 2013 (53 years). We found clear evidences that in general high magnitude earthquake events and their depth were related to the low solar activity.

  4. On the possible relations between solar activities and global seismicity in the solar cycle 20 to 23

    Solar activities consist of high energetic particle streams, electromagnetic radiation, magnetic and orbital gravitational forces. The well-know solar activity main indicator is the existence of sunspot which has mean variation in 11 years, named by solar cycle, allow for the above fluctuations. Solar activities are also related to the space weather affecting all planetary atmospheric variability, moreover to the Earth’s climate variability. Large extreme space and geophysical events (high magnitude earthquakes, explosive volcanic eruptions, magnetic storms, etc.) are hazards for humankind, infrastructure, economies, technology and the activities of civilization. With a growing world population, and with modern reliance on delicate technological systems, human society is becoming increasingly vulnerable to natural hazardous events. The big question arises to the relation between solar forcing energy to the Earth’s global seismic activities. Estimates are needed for the long term occurrence-rate probabilities of these extreme natural hazardous events. We studied connectivity from yearly seismic activities that refer to and sunspot number within the solar cycle 20 to 23 of year 1960 to 2013 (53 years). We found clear evidences that in general high magnitude earthquake events and their depth were related to the low solar activity

  5. Dichlorodiphenyltrichloroethane technical mixture regulates cell cycle and apoptosis genes through the activation of CAR and ERα in mouse livers

    Dichlorodiphenyltrichloroethane (DDT) is a widely used organochlorine pesticide and a xenoestrogen that promotes rodent hepatomegaly and tumours. A recent study has shown significant correlation between DDT serum concentration and liver cancer incidence in humans, but the underlying mechanisms remain elusive. We hypothesised that a mixture of DDT isomers could exert effects on the liver through pathways instead of classical ERs. The acute effects of a DDT mixture containing the two major isomers p,p′-DDT (85%) and o,p′-DDT (15%) on CAR and ERα receptors and their cell cycle and apoptosis target genes were studied in mouse livers. ChIP results demonstrated increased CAR and ERα recruitment to their specific target gene binding sites in response to the DDT mixture. The results of real-time RT-PCR were consistent with the ChIP data and demonstrated that the DDT was able to activate both CAR and ERα in mouse livers, leading to target gene transcriptional increases including Cyp2b10, Gadd45β, cMyc, Mdm2, Ccnd1, cFos and E2f1. Western blot analysis demonstrated increases in cell cycle progression proteins cMyc, Cyclin D1, CDK4 and E2f1 and anti-apoptosis proteins Mdm2 and Gadd45β. In addition, DDT exposure led to Rb phosphorylation. Increases in cell cycle progression and anti-apoptosis proteins were accompanied by a decrease in p53 content and its transcriptional activity. However, the DDT was unable to stimulate the β-catenin signalling pathway, which can play an important role in hepatocyte proliferation. Thus, our results indicate that DDT treatment may result in cell cycle progression and apoptosis inhibition through CAR- and ERα-mediated gene activation in mouse livers. These findings suggest that the proliferative and anti-apoptotic conditions induced by CAR and ERα activation may be important contributors to the early stages of hepatocarcinogenesis as produced by DDT in rodent livers. - Highlights: • DDT activated both CAR and ERα and their cell

  6. Dichlorodiphenyltrichloroethane technical mixture regulates cell cycle and apoptosis genes through the activation of CAR and ERα in mouse livers

    Kazantseva, Yuliya A.; Yarushkin, Andrei A. [Institute of Molecular Biology and Biophysics SB RAMS, Novosibirsk, Timakova str., 2, 630117 (Russian Federation); Pustylnyak, Vladimir O., E-mail: pustylnyak@ngs.ru [Institute of Molecular Biology and Biophysics SB RAMS, Novosibirsk, Timakova str., 2, 630117 (Russian Federation); Novosibirsk State University, Novosibirsk, Pirogova str., 2, 630090 (Russian Federation)

    2013-09-01

    Dichlorodiphenyltrichloroethane (DDT) is a widely used organochlorine pesticide and a xenoestrogen that promotes rodent hepatomegaly and tumours. A recent study has shown significant correlation between DDT serum concentration and liver cancer incidence in humans, but the underlying mechanisms remain elusive. We hypothesised that a mixture of DDT isomers could exert effects on the liver through pathways instead of classical ERs. The acute effects of a DDT mixture containing the two major isomers p,p′-DDT (85%) and o,p′-DDT (15%) on CAR and ERα receptors and their cell cycle and apoptosis target genes were studied in mouse livers. ChIP results demonstrated increased CAR and ERα recruitment to their specific target gene binding sites in response to the DDT mixture. The results of real-time RT-PCR were consistent with the ChIP data and demonstrated that the DDT was able to activate both CAR and ERα in mouse livers, leading to target gene transcriptional increases including Cyp2b10, Gadd45β, cMyc, Mdm2, Ccnd1, cFos and E2f1. Western blot analysis demonstrated increases in cell cycle progression proteins cMyc, Cyclin D1, CDK4 and E2f1 and anti-apoptosis proteins Mdm2 and Gadd45β. In addition, DDT exposure led to Rb phosphorylation. Increases in cell cycle progression and anti-apoptosis proteins were accompanied by a decrease in p53 content and its transcriptional activity. However, the DDT was unable to stimulate the β-catenin signalling pathway, which can play an important role in hepatocyte proliferation. Thus, our results indicate that DDT treatment may result in cell cycle progression and apoptosis inhibition through CAR- and ERα-mediated gene activation in mouse livers. These findings suggest that the proliferative and anti-apoptotic conditions induced by CAR and ERα activation may be important contributors to the early stages of hepatocarcinogenesis as produced by DDT in rodent livers. - Highlights: • DDT activated both CAR and ERα and their cell

  7. The sunspot cycle no. 24 in relation to long term solar activity variation

    Boris Komitov; Vladimir Kaftan

    2013-01-01

    The solar minimum between solar cycles 23 and 24 during the period 2007–2009 has been the longest and deepest one at least since for the last 100 years. We suggest that the Sun is going to his next supercenturial minimum. The main aim of this paper is to tell about arguments concerning this statement. They are based on series of studies, which have been provided during the period since 1997 up to 2010. The progress of solar cycle 24 since its minimum at the end of 2008 up to the end of Octobe...

  8. Activation of the ribosomal RNA genes late in the third cell cycle of porcine embryos

    Viuff, Dorthe; Greve, Torben; Holm, Peter; Callesen, Henrik; Hyttel, Poul; Thomsen, Preben D

    2002-01-01

    In porcine embryos, nucleoli are first observed during the third postfertilization cell cycle, i.e., at the 4-cell stage. However, direct studies of the initiation of rRNA transcription have not been reported. This transcription was investigated in the present study by simultaneous visualization of...... electron microscopy. In general, the 2-cell and 4-cell embryos fixed at 10 and 20 h postcleavage (hpc) showed no signs of rRNA transcription. Four small clusters of fluorescein isothiocyanate (FITC) labeling were visible in interphase nuclei, consistent with hybridization to the rRNA gene clusters only...... phase during the third cell cycle....

  9. New activators and inhibitors in the hair cycle clock: targeting stem cells' state of competence.

    Plikus, Maksim V

    2012-05-01

    The timing mechanism of the hair cycle remains poorly understood. However, it has become increasingly clear that the telogen-to-anagen transition is controlled jointly by at least the bone morphogenic protein (BMP), WNT, fibroblast growth factor (FGF), and transforming growth factor (TGF)-β signaling pathways. New research shows that Fgf18 signaling in hair follicle stem cells synergizes BMP-mediated refractivity, whereas Tgf-β2 signaling counterbalances it. Loss of Fgf18 signaling markedly accelerates anagen initiation, whereas loss of Tgf-β2 signaling significantly delays it, supporting key roles for these pathways in hair cycle timekeeping. PMID:22499035

  10. Turbulent Pumping of Magnetic Flux Reduces Solar Cycle Memory and thus Impacts Predictability of the Sun's Activity

    Karak, Bidya Binay

    2012-01-01

    Prediction of the Sun's magnetic activity is important because of its effect on space environmental conditions and climate. However, recent efforts to predict the amplitude of the solar cycle have resulted in diverging forecasts with no consensus. It is understood that the dynamical memory of the solar dynamo mechanism governs predictability and this memory is different for advection- and diffusion-dominated solar convection zones. By utilizing stochastically forced, kinematic dynamo simulations, we demonstrate that the inclusion of downward turbulent pumping of magnetic flux reduces the memory of both advection- and diffusion-dominated solar dynamos to only one cycle; stronger pumping degrades this memory further. We conclude that reliable predictions for the maximum of solar activity can be made only at the preceding minimum and for more accurate predictions, sequential data assimilation would be necessary in forecasting models to account for the Sun's short memory.