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Sample records for active episomal hat

  1. Transpositionally active episomal hAT elements

    Hice Robert H

    2009-12-01

    Full Text Available Abstract Background hAT elements and V(DJ recombination may have evolved from a common ancestral transposable element system. Extrachromosomal, circular forms of transposable elements (referred to here as episomal forms have been reported yet their biological significance remains unknown. V(DJ signal joints, which resemble episomal transposable elements, have been considered non-recombinogenic products of V(DJ recombination and a safe way to dispose of excised chromosomal sequences. V(DJ signal joints can, however, participate in recombination reactions and the purpose of this study was to determine if hobo and Hermes episomal elements are also recombinogenic. Results Up to 50% of hobo/Hermes episomes contained two intact, inverted-terminal repeats and 86% of these contained from 1-1000 bp of intercalary DNA. Episomal hobo/Hermes elements were recovered from Musca domestica (a natural host of Hermes, Drosophila melanogaster (a natural host of hobo and transgenic Drosophila melanogaster and Aedes aegypti (with autonomous Hermes elements. Episomal Hermes elements were recovered from unfertilized eggs of M. domestica and D. melanogaster demonstrating their potential for extrachromosomal, maternal transmission. Reintegration of episomal Hermes elements was observed in vitro and in vivo and the presence of Hermes episomes resulted in lower rates of canonical Hermes transposition in vivo. Conclusion Episomal hobo/Hermes elements are common products of element excision and can be maternally transmitted. Episomal forms of Hermes are capable of integration and also of influencing the transposition of canonical elements suggesting biological roles for these extrachromosomal elements in element transmission and regulation.

  2. Antioxidant Activity/Capacity Measurement. 2. Hydrogen Atom Transfer (HAT)-Based, Mixed-Mode (Electron Transfer (ET)/HAT), and Lipid Peroxidation Assays.

    Apak, Reşat; Özyürek, Mustafa; Güçlü, Kubilay; Çapanoğlu, Esra

    2016-02-10

    Measuring the antioxidant activity/capacity levels of food extracts and biological fluids is useful for determining the nutritional value of foodstuffs and for the diagnosis, treatment, and follow-up of numerous oxidative stress-related diseases. Biologically, antioxidants play their health-beneficial roles via transferring a hydrogen (H) atom or an electron (e(-)) to reactive species, thereby deactivating them. Antioxidant activity assays imitate this action; that is, antioxidants are measured by their H atom transfer (HAT) or e(-) transfer (ET) to probe molecules. Antioxidant activity/capacity can be monitored by a wide variety of assays with different mechanisms, including HAT, ET, and mixed-mode (ET/HAT) assays, generally without distinct boundaries between them. Understanding the principal mechanisms, advantages, and disadvantages of the measurement assays is important for proper selection of method for valid evaluation of antioxidant properties in desired applications. This work provides a general and up-to-date overview of HAT-based, mixed-mode (ET/HAT), and lipid peroxidation assays available for measuring antioxidant activity/capacity and the chemistry behind them, including a critical evaluation of their advantages and drawbacks. PMID:26805392

  3. HAT activity is essential for CBP-1-dependent transcription and differentiation in Caenorhabditis elegans

    Victor, Martin; Bei, Yanxia; Gay, Frédérique; Calvo, Dominica; Mello, Craig; Shi, Yang

    2002-01-01

    The p300/CBP family of transcriptional coactivators possesses multiple functional domains, including a histone acetyltransferase (HAT) and several activation domains. A number of models have been proposed to account for their roles in transcriptional activation, including interactions with basal transcription machinery and chromatin remodeling. However, individual contributions of these domains to transcriptional activation and their significance in living organisms remain unclear. We address...

  4. HATS-2b: A transiting extrasolar planet orbiting a K-type star showing starspot activity

    Mohler-Fischer, M; Hartman, J D; Bakos, G B; Penev, K; Bayliss, D; Jordan, A; Csubry, Z; Zhou, G; Rabus, M; Nikolov, N; Brahm, R; Espinoza, N; Buchhave, L A; Beky, B; Suc, V; Csak, B; Henning, T; Wright, D J; Tinney, C G; Addison, B C; Schmidt, B; Noyes, R W; Papp, I; Lazar, J; Sari, P; Conroy, P

    2013-01-01

    We report the discovery of HATS-2b, the second transiting extrasolar planet detected by the HATSouth survey. HATS-2b is moving on a circular orbit around a V=13.6 mag, K-type dwarf star (GSC 6665-00236), at a separation of 0.0230 \\pm 0.0003 AU and with a period of 1.3541 days. The planetary parameters have been robustly determined using a simultaneous fit of the HATSouth, MPG/ESO~2.2\\,m/GROND, Faulkes Telescope South/Spectral transit photometry and MPG/ESO~2.2\\,m/FEROS, Euler~1.2\\,m/CORALIE, AAT~3.9\\,m/CYCLOPS radial-velocity measurements. HATS-2b has a mass of 1.37 \\pm 0.16 M_J, a radius of 1.14 \\pm 0.03 R_J and an equilibrium temperature of 1567 \\pm 30 K. The host star has a mass of 0.88 \\pm 0.04 M_Sun, radius of 0.89 \\pm 0.02 R_Sun and shows starspot activity. We characterized the stellar activity by analysing two photometric follow-up transit light curves taken with the GROND instrument, both obtained simultaneously in four optical bands (covering the wavelength range of 3860-9520 \\AA). The two light curv...

  5. Imbalance between HAT and HDAC activities in the PBMCs of patients with ankylosing spondylitis or rheumatoid arthritis and influence of HDAC inhibitors on TNF alpha production.

    Eric Toussirot

    Full Text Available OBJECTIVE: Acetylation or deacetylation of histone proteins may modulate cytokine gene transcription such as TNF alpha (TNF. We evaluated the balance between histone deacetytlase (HDAC and histone acetyltransferase (HAT in patients with rheumatoid arthritis (RA or ankylosing spondylitis (AS compared to healthy controls (HC and determined the influence of HDAC inhibitors (trichostatin A -TSA- or Sirtinol -Sirt- on these enzymatic activities and on the PBMC production of TNF. METHODS: 52 patients with RA, 21 with AS and 38 HC were evaluated. HAT and HDAC activities were measured on nuclear extracts from PBMC using colorimetric assays. Enzymatic activities were determined prior to and after ex vivo treatment of PBMC by TSA or Sirt. TNF levels were evaluated in PBMC culture supernatants in the absence or presence of TSA or Sirt. RESULTS: HAT and HDAC activities were significantly reduced in AS, while these activities reached similar levels in RA and HC. Ex vivo treatment of PBMC by HDACi tended to decrease HDAC expression in HC, but Sirt significantly reduced HAT in RA. TNF production by PBMC was significantly down-regulated by Sirt in HC and AS patients. CONCLUSION: HAT and HDAC were disturbed in AS while no major changes were found in RA. HDACi may modulate HDAC and HAT PBMC expression, especially Sirt in RA. Sirtinol was able to down regulate TNF production by PBMC in HC and AS. An imbalance between HAT and HDAC activities might provide the rationale for the development of HDACi in the therapeutic approach to inflammatory rheumatic diseases.

  6. Yet Another Hat Game

    Paterson, Maura B

    2010-01-01

    Several different "hat games" have recently received a fair amount of attention. Typically, in a hat game, one or more players are required to correctly guess their hat colour when given some information about other players' hat colours. Some versions of these games have been motivated by research in complexity theory and have ties to well-known research problems in coding theory, and some variations have led to interesting new research. In this paper, we review Ebert's Hat Game, which garnered a considerable amount of publicity in the late 90's and early 00's, and the Hats-on-a-line Game. Then we introduce a new hat game which is a "hybrid" of these two games and provide an optimal strategy for playing the new game. The optimal strategy is quite simple, but the proof involves an interesting combinatorial argument.

  7. Quiescent and proliferative fibroblasts exhibit differential p300 HAT activation through control of 5-methoxytryptophan production.

    Huei-Hsuan Cheng

    Full Text Available Quiescent fibroblasts possess unique genetic program and exhibit high metabolic activity distinct from proliferative fibroblasts. In response to inflammatory stimulation, quiescent fibroblasts are more active in expressing cyclooxygenase-2 and other proinflammatory genes than proliferative fibroblasts. The underlying transcriptional mechanism is unclear. Here we show that phorbol 12-myristate 13-acetate (PMA and cytokines increased p300 histone acetyltransferase activity to a higher magnitude (> 2 fold in quiescent fibroblasts than in proliferative fibroblasts. Binding of p300 to cyclooxygenase-2 promoter was reduced in proliferative fibroblasts. By ultrahigh-performance liquid chromatography coupled with a quadrupole time of flight mass spectrometer and enzyme-immunoassay, we found that production of 5-methoxytryptophan was 2-3 folds higher in proliferative fibroblasts than that in quiescent fibroblasts. Addition of 5-methoxytryptophan and its metabolic precursor, 5-hydroxytryptophan, to quiescent fibroblasts suppressed PMA-induced p300 histone acetyltransferase activity and cyclooxygenase-2 expression to the level of proliferative fibroblasts. Silencing of tryptophan hydroxylase-1 or hydroxyindole O-methyltransferase in proliferative fibroblasts with siRNA resulted in elevation of PMA-induced p300 histone acetyltransferase activity to the level of that in quiescent fibroblasts, which was rescued by addition of 5-hydroxytryptophan or 5-methoxytryptophan. Our findings indicate that robust inflammatory gene expression in quiescent fibroblasts vs. proliferative fibroblasts is attributed to uncontrolled p300 histone acetyltransferase activation due to deficiency of 5-methoxytryptophan production. 5-methoxytryptophan thus is a potential valuable lead compound for new anti-inflammatory drug development.

  8. Influenza and SARS-coronavirus activating proteases TMPRSS2 and HAT are expressed at multiple sites in human respiratory and gastrointestinal tracts.

    Stephanie Bertram

    Full Text Available The type II transmembrane serine proteases TMPRSS2 and HAT activate influenza viruses and the SARS-coronavirus (TMPRSS2 in cell culture and may play an important role in viral spread and pathogenesis in the infected host. However, it is at present largely unclear to what extent these proteases are expressed in viral target cells in human tissues. Here, we show that both HAT and TMPRSS2 are coexpressed with 2,6-linked sialic acids, the major receptor determinant of human influenza viruses, throughout the human respiratory tract. Similarly, coexpression of ACE2, the SARS-coronavirus receptor, and TMPRSS2 was frequently found in the upper and lower aerodigestive tract, with the exception of the vocal folds, epiglottis and trachea. Finally, activation of influenza virus was conserved between human, avian and porcine TMPRSS2, suggesting that this protease might activate influenza virus in reservoir-, intermediate- and human hosts. In sum, our results show that TMPRSS2 and HAT are expressed by important influenza and SARS-coronavirus target cells and could thus support viral spread in the human host.

  9. Association with the origin recognition complex suggests a novel role for histone acetyltransferase Hat1p/Hat2p

    Greenblatt Jack F

    2007-09-01

    Full Text Available Abstract Background Histone modifications have been implicated in the regulation of transcription and, more recently, in DNA replication and repair. In yeast, a major conserved histone acetyltransferase, Hat1p, preferentially acetylates lysine residues 5 and 12 on histone H4. Results Here, we report that a nuclear sub-complex consisting of Hat1p and its partner Hat2p interacts physically and functionally with the origin recognition complex (ORC. While mutational inactivation of the histone acetyltransferase (HAT gene HAT1 alone does not compromise origin firing or initiation of DNA replication, a deletion in HAT1 (or HAT2 exacerbates the growth defects of conditional orc-ts mutants. Thus, the ORC-associated Hat1p-dependent histone acetyltransferase activity suggests a novel linkage between histone modification and DNA replication. Additional genetic and biochemical evidence points to the existence of partly overlapping histone H3 acetyltransferase activities in addition to Hat1p/Hat2p for proper DNA replication efficiency. Furthermore, we demonstrated a dynamic association of Hat1p with chromatin during S-phase that suggests a role of this enzyme at the replication fork. Conclusion We have found an intriguing new association of the Hat1p-dependent histone acetyltransferase in addition to its previously known role in nuclear chromatin assembly (Hat1p/Hat2p-Hif1p. The participation of a distinct Hat1p/Hat2p sub-complex suggests a linkage of histone H4 modification with ORC-dependent DNA replication.

  10. A role for MRE11, NBS1, and recombination junctions in replication and stable maintenance of EBV episomes.

    Jayaraju Dheekollu

    Full Text Available Recombination-like structures formed at origins of DNA replication may contribute to replication fidelity, sister chromatid cohesion, chromosome segregation, and overall genome stability. The Epstein-Barr Virus (EBV origin of plasmid replication (OriP provides episomal genome stability through a poorly understood mechanism. We show here that recombinational repair proteins MRE11 and NBS1 are recruited to the Dyad Symmetry (DS region of OriP in a TRF2- and cell cycle-dependent manner. Depletion of MRE11 or NBS1 by siRNA inhibits OriP replication and destabilized viral episomes. OriP plasmid maintenance was defective in MRE11 and NBS1 hypomorphic fibroblast cell lines and only integrated, non-episomal forms of EBV were detected in a lympoblastoid cell line derived from an NBS1-mutated individual. Two-dimensional agarose gel analysis of OriP DNA revealed that recombination-like structures resembling Holliday-junctions form at OriP in mid S phase. MRE11 and NBS1 association with DS coincided with replication fork pausing and origin activation, which preceded the formation of recombination structures. We propose that NBS1 and MRE11 promote replication-associated recombination junctions essential for EBV episomal maintenance and genome stability.

  11. Histone acetyltransferase (HAT) activity of p300 modulates human T lymphotropic virus type 1 p30II-mediated repression of LTR transcriptional activity

    Human T-lymphotropic virus type-1 (HTLV-1) is a deltaretrovirus that causes adult T cell leukemia/lymphoma, and is implicated in a variety of lymphocyte-mediated inflammatory disorders. HTLV-1 provirus has regulatory and accessory genes in four pX open reading frames. HTLV-1 pX ORF-II encodes two proteins, p13II and p30II, which are incompletely defined in virus replication or pathogenesis. We have demonstrated that pX ORF-II mutations block virus replication in vivo and that ORF-II encoded p30II, a nuclear-localizing protein that binds with CREB-binding protein (CBP)/p300, represses CREB and Tax responsive element (TRE)-mediated transcription. Herein, we have identified p30II motifs important for p300 binding and in regulating TRE-mediated transcription in the absence and presence of HTLV-1 provirus. Within amino acids 100-179 of p30II, a region important for repression of LTR-mediated transcription, we identified a single lysine residue at amino acid 106 (K3) that significantly modulates the ability of p30II to repress TRE-mediated transcription. Exogenous p300, in a dose-responsive manner, reverses p30II-dependent repression of TRE-mediated transcription, in the absence or presence of the provirus, In contrast to wild type p300, p300 HAT mutants (defective in histone acetyltransferase activity) only partially rescued p30II-mediated LTR repression. Deacetylation by histone deacetylase-1 (HDAC-1) enhanced p30II-mediated LTR repression, while inhibition of deacetylation by trichostatin A decreases p30II-mediated LTR repression. Collectively, our data indicate that HTLV-1 p30II modulates viral gene expression in a cooperative manner with p300-mediated acetylation

  12. Recombinant Adeno-Associated Virus Vector Genomes Take the Form of Long-Lived, Transcriptionally Competent Episomes in Human Muscle.

    Schnepp, Bruce C; Chulay, Jeffrey D; Ye, Guo-Jie; Flotte, Terence R; Trapnell, Bruce C; Johnson, Philip R

    2016-01-01

    Gene augmentation therapy as a strategy to treat alpha-1 antitrypsin (AAT) deficiency has reached phase 2 clinical testing in humans. Sustained serum levels of AAT have been observed beyond one year after intramuscular administration of a recombinant adeno-associated virus (rAAV) vector expressing the AAT gene. In this study, sequential muscle biopsies obtained at 3 and 12 months after vector injection were examined for the presence of rAAV vector genomes. Each biopsy sample contained readily detectable vector DNA, the majority of which existed as double-stranded supercoiled and open circular episomes. Episomes persisted through 12 months, although at slightly lower levels than observed at 3 months. There was a clear dose response when comparing the low- and mid-vector-dose groups to the high-dose group. The highest absolute copy numbers were found in a high-dose subject, and serum AAT levels at 12 months confirmed that the high-dose group also had the highest sustained serum AAT levels. Sequence analysis revealed that the vast majority of episomes contained double-D inverted terminal repeats ranging from fully intact to severely deleted. Molecular clones of vector genomes derived directly from the biopsies were transcriptionally active, potentially identifying them as the source of serum AAT in the trial subjects. PMID:26650966

  13. HATS-15 b and HATS-16 b: Two massive planets transiting old G dwarf stars

    Ciceri, S; Henning, T; Bakos, G Á; Penev, K; Brahm, R; Zhou, G; Hartman, J D; Bayliss, D; Jordán, A; Csubry, Z; de Val-Borro, M; Bhatti, W; Rabus, M; Espinoza, N; Suc, V; Schmidt, B; Noyes, R; Howard, A W; Fulton, B J; Isaacson, H; Marcy, G W; Butler, R P; Arriagada, P; Crane, J; Shectman, S; Thompson, I; Tan, T G; Lázár, J; Papp, I; Sari, P

    2015-01-01

    We report the discovery of HATS-15 b and HATS-16 b, two massive transiting extrasolar planets orbiting evolved ($\\sim 10$ Gyr) main-sequence stars. The planet HATS-15 b, which is hosted by a G9V star ($V=14.8$ mag), is a hot Jupiter with mass of $2.17\\pm0.15\\, M_{\\mathrm{J}}$ and radius of $1.105\\pm0.0.040\\, R_{\\mathrm{J}}$, and completes its orbit in nearly 1.7 days. HATS-16 b is a very massive hot Jupiter with mass of $3.27\\pm0.19\\, M_{\\mathrm{J}}$ and radius of $1.30\\pm0.15\\, R_{\\mathrm{J}}$; it orbits around its G3 V parent star ($V=13.8$ mag) in $\\sim2.7$ days. HATS-16 is slightly active and shows a periodic photometric modulation, implying a rotational period of 12 days which is unexpectedly short given its isochronal age. This fast rotation might be the result of the tidal interaction between the star and its planet.

  14. DIY teleport hats - the consolation of technology

    Hansen, Lone Koefoed

    2009-01-01

    This instructable describes how to make a set of teleport hats. A teleport hat is a crocheted hat which doubles as a device with which you can teleport yourself to a person wearing the same type of hat in case you miss oneanother and want to be together without the hassle of driving, jetting or...

  15. Delivery of episomal vectors into primary cells by means of commercial transfection reagents.

    Han, Na Rae; Lee, Hyun; Baek, Song; Yun, Jung Im; Park, Kyu Hyun; Lee, Seung Tae

    2015-05-29

    Although episomal vectors are commonly transported into cells by electroporation, a number of electroporation-derived problems have led to the search for alternative transfection protocols, such as the use of transfection reagents, which are inexpensive and easy to handle. Polyplex-mediated transport of episomal vectors into the cytoplasm has been conducted successfully in immortalized cell lines, but no report exists of successful transfection of primary cells using this method. Accordingly, we sought to optimize the conditions for polyplex-mediated transfection for effective delivery of episomal vectors into the cytoplasm of primary mouse embryonic fibroblasts. Episomal vectors were complexed with the commercially available transfection reagents Lipofectamine 2000, FuGEND HD and jetPEI. The ratio of transfection reagent to episomal vectors was varied, and the subsequent transfection efficiency and cytotoxicity of the complexes were analyzed using flow cytometry and trypan blue exclusion assay, respectively. No cytotoxicity and the highest transfection yield were observed when the ratio of transfection reagent to episomal vector was 4 (v/wt) in the cases of Lipofectamine 2000 and FuGENE HD, and 2 in the case of jetPEI. Of the three transfection reagents tested, jetPEI showed the highest transfection efficiency without any cytotoxicity. Thus, we confirmed that the transfection reagent jetPEI could be used to effectively deliver episomal vectors into primary cells without electroporation. PMID:25887802

  16. The stealth episome: suppression of gene expression on the excised genomic island PPHGI-1 from Pseudomonas syringae pv. phaseolicola.

    Scott A C Godfrey

    2011-03-01

    Full Text Available Pseudomonas syringae pv. phaseolicola is the causative agent of halo blight in the common bean, Phaseolus vulgaris. P. syringae pv. phaseolicola race 4 strain 1302A contains the avirulence gene avrPphB (syn. hopAR1, which resides on PPHGI-1, a 106 kb genomic island. Loss of PPHGI-1 from P. syringae pv. phaseolicola 1302A following exposure to the hypersensitive resistance response (HR leads to the evolution of strains with altered virulence. Here we have used fluorescent protein reporter systems to gain insight into the mobility of PPHGI-1. Confocal imaging of dual-labelled P. syringae pv. phaseolicola 1302A strain, F532 (dsRFP in chromosome and eGFP in PPHGI-1, revealed loss of PPHGI-1::eGFP encoded fluorescence during plant infection and when grown in vitro on extracted leaf apoplastic fluids. Fluorescence-activated cell sorting (FACS of fluorescent and non-fluorescent PPHGI-1::eGFP F532 populations showed that cells lost fluorescence not only when the GI was deleted, but also when it had excised and was present as a circular episome. In addition to reduced expression of eGFP, quantitative PCR on sub-populations separated by FACS showed that transcription of other genes on PPHGI-1 (avrPphB and xerC was also greatly reduced in F532 cells harbouring the excised PPHGI-1::eGFP episome. Our results show how virulence determinants located on mobile pathogenicity islands may be hidden from detection by host surveillance systems through the suppression of gene expression in the episomal state.

  17. Hat das Internet ein Programm?

    Coy, Wolfgang

    1998-01-01

    Hat das Internet ein Programm? Ist der Papst katholisch? Natürlich hat das Internet Millionen Programme - solche, die es nutzt und solche die man per FTP - File Transfer Protocol auf die eigene Maschine herunter laden kann und solche, die sich unbemerkt auf der Festplatte festsetzen. Letztere heißen Viren, Würmer oder trojanische Pferde. Aber das sind natürlich Programme im Sinne der Informatik, nicht im Sinne der broadcast media. Im amerikanisch-englischen Sprachraum, dem die...

  18. Plasticity of DNA Replication Initiation in Epstein-Barr Virus Episomes

    Norio Paolo

    2004-01-01

    Full Text Available In mammalian cells, the activity of the sites of initiation of DNA replication appears to be influenced epigenetically, but this regulation is not fully understood. Most studies of DNA replication have focused on the activity of individual initiation sites, making it difficult to evaluate the impact of changes in initiation activity on the replication of entire genomic loci. Here, we used single molecule analysis of replicated DNA (SMARD to study the latent duplication of Epstein-Barr virus (EBV episomes in human cell lines. We found that initiation sites are present throughout the EBV genome and that their utilization is not conserved in different EBV strains. In addition, SMARD shows that modifications in the utilization of multiple initiation sites occur across large genomic regions (tens of kilobases in size. These observations indicate that individual initiation sites play a limited role in determining the replication dynamics of the EBV genome. Long-range mechanisms and the genomic context appear to play much more important roles, affecting the frequency of utilization and the order of activation of multiple initiation sites. Finally, these results confirm that initiation sites are extremely redundant elements of the EBV genome. We propose that these conclusions also apply to mammalian chromosomes.

  19. New year, old hat

    American Geological Institute; American Institute of Physics; American Associationthe Advancement of Science; Carlowicz, Michael

    It is only August, but October 1 looms large on the calendar. That is the day when the 1997 fiscal year (FY ‧97) begins for the U.S. federal government, and like last year, that day might come without a budget.In a flurry of summer activity, the U.S. Congress has passed several landmark bills on welfare reform, expansion of health coverage for workers between jobs, a raise in the minimum wage, and a Safe Drinking Water Act. The House of Representatives even passed all 13 of its annual appropriations bills before Congress took its August recess.

  20. Gamma-herpesvirus latency requires T cell evasion during episome maintenance.

    Neil J Bennett

    2005-04-01

    Full Text Available The gamma-herpesviruses persist as latent episomes in a dynamic lymphocyte pool. Their consequent need to express a viral episome maintenance protein presents a potential immune target. The glycine-alanine repeat of the Epstein-Barr virus episome maintenance protein, EBNA-1, limits EBNA-1 epitope presentation to CD8(+ T lymphocytes (CTLs. However, CTL recognition occurs in vitro, so the significance of such evasion for viral fitness is unclear. We used the murine gamma-herpesvirus-68 (MHV-68 to define the in vivo contribution of cis-acting CTL evasion to host colonisation. Although the ORF73 episome maintenance protein of MHV-68 lacks a glycine-alanine repeat, it was equivalent to EBNA-1 in conferring limited presentation on linked epitopes. This was associated with reduced protein synthesis and reduced protein degradation. We bypassed the cis-acting evasion of ORF73 by using an internal ribosome entry site to express in trans-a CTL target from the same mRNA. This led to a severe, MHC class I-restricted and CTL-dependent reduction in viral latency. Thus, despite MHV-68 encoding at least two trans-acting CTL evasion proteins, cis-acting evasion during episome maintenance was essential for normal host colonisation.

  1. HAT-P-38h

    Sato, Bun'ei; Hartman, Joel D.; Bakos, Gaspar A.;

    2012-01-01

    We report on the discovery of HAT-P-38b, a Saturn-mass exoplanet, transiting the V = 12.56 dwarf star GSC 2314-00559 on a P = 4.6404 d circular orbit. The host star is a 0.89 M-circle dot late G dwarf, with solar metallicity and a radius of 0.92 R-circle dot. The planetary companion has a mass of...

  2. HAT-P-25b

    Quinn, S.N.; Bakos, G. 'A; Hartman, J.;

    2012-01-01

    We report the discovery of HAT-P-25b, a transiting extrasolar planet orbiting the V = 13.19 G5 dwarf star GSC 1788-01237, with a period P = 3.652836 +/- 0.000019 days, transit epoch Tc = 2455176.85173 +/- 0.00047 (BJD), and transit duration 0.1174 +/- 0.0017 days. The host star has mass of 1.01 +...

  3. HATS-19b, HATS-20b, HATS-21b: Three Transiting Hot-Saturns Discovered by the HATSouth Survey

    Bhatti, W.; Bakos, G. Á.; Hartman, J. D.; Zhou, G.; Penev, K.; Bayliss, D.; Jordán, A.; Brahm, R.; Espinoza, N.; Rabus, M.; Mancini, L; de Val-Borro, M.; Bento, J; Ciceri, S.; Csubry, Z.

    2016-01-01

    We report the discovery by the HATSouth exoplanet survey of three hot-Saturn transiting exoplanets: HATS-19b, HATS-20b, and HATS-21b. The planet host HATS-19 is a slightly evolved V = 13.0 G0 star with [Fe/H] = 0.240, a mass of 1.303 Msun, and a radius of 1.75 Rsun. HATS-19b is in an eccentric orbit (e = 0.30) around this star with an orbital period of 4.5697 days and has a mass of 0.427 Mjup and a highly inflated radius of 1.66 Rjup. The planet HATS-20b has a Saturn-like mass and radius of 0...

  4. HATS-19b, HATS-20b, HATS-21b: Three Transiting Hot-Saturns Discovered by the HATSouth Survey

    Bhatti, W; Hartman, J D; Zhou, G; Penev, K; Bayliss, D; Jordán, A; Brahm, R; Espinoza, N; Rabus, M; Mancini, L; de Val-Borro, M; Bento, J; Ciceri, S; Csubry, Z; Henning, T; Schmidt, B; Arriagada, P; Butler, R P; Crane, J; Shectman, S; Thompson, I; Tan, T G; Suc, V; Lázár, J; Papp, I; Sári, P

    2016-01-01

    We report the discovery by the HATSouth exoplanet survey of three hot-Saturn transiting exoplanets: HATS-19b, HATS-20b, and HATS-21b. The planet host HATS-19 is a slightly evolved V = 13.0 G0 star with [Fe/H] = 0.240, a mass of 1.303 Msun, and a radius of 1.75 Rsun. HATS-19b is in an eccentric orbit (e = 0.30) around this star with an orbital period of 4.5697 days and has a mass of 0.427 Mjup and a highly inflated radius of 1.66 Rjup. The planet HATS-20b has a Saturn-like mass and radius of 0.273 Mjup and 0.776 Rjup respectively. It orbits the V = 13.8 G9V star HATS-20 (Ms = 0.910 Msun; Rs = 0.892 Rsun) with a period of 3.7993 days. Finally, HATS-21 is a V = 12.2 G4V star with [Fe/H] = 0.300, a mass of 1.080 Msun, and a radius of 1.021 Rsun. Its accompanying planet HATS-21b has a 3.5544-day orbital period, a mass of 0.332 Mjup, and a moderately inflated radius of 1.123 Rjup. With the addition of these three very different planets to the growing sample of hot-Saturns, we re-examine the relations between the ob...

  5. Long-term surveillance plan for the Mexican Hat disposal site, Mexican Hat, Utah

    This plan describes the long-term surveillance activities for the Uranium Mill Tailings Remedial Action (UMTRA) Project disposal site at Mexican Hat, Utah. The US Department of Energy (DOE) will carry out these activities to ensure that the disposal site continues to function as designed. This long-term surveillance plan (LTSP) was prepared as a requirement for acceptance under the US Nuclear Regulatory Commission (NRC) general license for custody and long-term care of residual radioactive material (RRM). This LTSPC documents the land ownership interests and details how the long-term care of the disposal site will be accomplished

  6. Long-term surveillance plan for the Mexican Hat disposal site, Mexican Hat, Utah

    NONE

    1996-01-01

    This plan describes the long-term surveillance activities for the Uranium Mill Tailings Remedial Action (UMTRA) Project disposal site at Mexican Hat, Utah. The US Department of Energy (DOE) will carry out these activities to ensure that the disposal site continues to function as designed. This long-term surveillance plan (LTSP) was prepared as a requirement for acceptance under the US Nuclear Regulatory Commission (NRC) general license for custody and long-term care of residual radioactive material (RRM). This LTSPC documents the land ownership interests and details how the long-term care of the disposal site will be accomplished.

  7. HATS-15b and HATS-16b: Two Massive Planets Transiting Old G Dwarf Stars

    Ciceri, S.; Mancini, L.; Henning, T.; Bakos, G.; Penev, K.; Brahm, R.; Zhou, G.; Hartman, J. D.; Bayliss, D.; Jordán, A.; Csubry, Z.; de Val-Borro, M.; Bhatti, W.; Rabus, M.; Espinoza, N.; Suc, V.; Schmidt, B.; Noyes, R.; Howard, A. W.; Fulton, B. J.; Isaacson, H.; Marcy, G. W.; Butler, R. P.; Arriagada, P.; Crane, J. D.; Shectman, S.; Thompson, I.; Tan, T. G.; Lázár, J.; Papp, I.; Sari, P.

    2016-07-01

    We report the discovery of HATS-15 b and HATS-16 b, two massive transiting extrasolar planets orbiting evolved (∼10 Gyr) main-sequence stars. The planet HATS-15 b, which is hosted by a G9 V star (V=14.8 mag), is a hot Jupiter with mass of 2.17\\quad +/- \\quad 0.15 {M}{{J}} and radius of 1.105\\quad +/- \\quad 0.040 {R}{{J}}, and it completes its orbit in about 1.7 days. HATS-16 b is a very massive hot Jupiter with mass of 3.27\\quad +/- \\quad 0.19 {M}{{J}} and radius of 1.30\\quad +/- \\quad 0.15 {R}{{J}}; it orbits around its G3 V parent star (V=13.8 mag) in ∼2.7 days. HATS-16 is slightly active and shows a periodic photometric modulation, implying a rotational period of 12 days, which is unexpectedly short given its isochronal age. This fast rotation might be the result of the tidal interaction between the star and its planet. The HATSouth network is operated by a collaboration consisting of Princeton University (PU), the Max Planck Institute für Astronomie (MPIA), the Australian National University (ANU), and the Pontificia Universidad Católica de Chile (PUC). The station at Las Campanas Observatory (LCO) of the Carnegie Institute is operated by PU in conjunction with PUC, the station at the High Energy Spectroscopic Survey (H.E.S.S.) site is operated in conjunction with MPIA, and the station at Siding Spring Observatory (SSO) is operated jointly with ANU. Based in part on observations performed at the ESO La Silla Observatory in Chile, with the Coralie and FEROS spectrographs mounted on the Euler-Swiss and MPG 2.2 m telescopes, respectively. This paper includes data gathered with the 6.5 m Magellan Telescopes located at Las Campanas Observatory, Chile. Based in part on data collected at Keck Telescope. Observations obtained with facilities of the Las Cumbres Observatory Global Telescope are used in this paper.

  8. Impact of Different Promoters on Episomal Vectors Harbouring Characteristic Motifs of Matrix Attachment Regions.

    Wang, Xiao-Yin; Zhang, Jun-He; Zhang, Xi; Sun, Qiu-Li; Zhao, Chun-Peng; Wang, Tian-Yun

    2016-01-01

    We previously demonstrated that the characteristic sequence of matrix attachment regions (MARs) allows transgenes to be maintained episomally in CHO cells. In the present study, six commonly used promoters from human cytomegalovirus major immediate-early (CMV), simian vacuolating virus 40 (SV40), Rous sarcoma virus, Homo sapiens ubiquitin C, phosphoglycerate kinase, and β-globin, respectively, were evaluated to determine their effects on transgene expression and stability in CHO cells stably transfected via the episomal vector harbouring characteristic MAR motifs. The CHO cells were transfected with vectors and then screened using G418, after which the stably transfected cells were split into two and further cultured either in the presence or absence of G418. Of the six promoters, the CMV promoter yielded the highest transgene expression levels and the highest transfection efficiency, whereas the SV40 promoter maintained transgene expression more stably during long-term culture than the other promoters did. The CMV and SV40 promoter-containing vectors were furthermore episomally maintained and conferred sustained eGFP expression in the cells even under nonselective conditions. On the basis of these findings, we conclude that the CMV promoter performs best in terms of yielding both high expression levels and high levels of stability using this episomal vector system. PMID:27226236

  9. Tip60 HAT Action Mediates Environmental Enrichment Induced Cognitive Restoration.

    Xu, Songjun; Panikker, Priyalakshmi; Iqbal, Sahira; Elefant, Felice

    2016-01-01

    Environmental enrichment (EE) conditions have beneficial effects for reinstating cognitive ability in neuropathological disorders like Alzheimer's disease (AD). While EE benefits involve epigenetic gene control mechanisms that comprise histone acetylation, the histone acetyltransferases (HATs) involved remain largely unknown. Here, we examine a role for Tip60 HAT action in mediating activity- dependent beneficial neuroadaptations to EE using the Drosophila CNS mushroom body (MB) as a well-characterized cognition model. We show that flies raised under EE conditions display enhanced MB axonal outgrowth, synaptic marker protein production, histone acetylation induction and transcriptional activation of cognition linked genes when compared to their genotypically identical siblings raised under isolated conditions. Further, these beneficial changes are impaired in both Tip60 HAT mutant flies and APP neurodegenerative flies. While EE conditions provide some beneficial neuroadaptive changes in the APP neurodegenerative fly MB, such positive changes are significantly enhanced by increasing MB Tip60 HAT levels. Our results implicate Tip60 as a critical mediator of EE-induced benefits, and provide broad insights into synergistic behavioral and epigenetic based therapeutic approaches for treatment of cognitive disorder. PMID:27454757

  10. ERRATUM: Work smart, wear your hard hat

    2003-01-01

    An error appeared in the article «Work smart, wear your hard hat» published in Weekly Bulletin 27/2003, page 5. The impact which pierced a hole in the hard hat worn by Gerd Fetchenhauer was the equivalent of a box weighing 5 kg and not 50 kg.

  11. The hat problem on a directed graph

    Hod, Rani

    2010-01-01

    A team of players plays the following game. After a strategy session, each player is randomly fitted with a blue or red hat. Then, without further communication, everybody can try to guess simultaneously his or her own hat color by looking at the hat colors of other players. Visibility is defined by a directed graph; that is, vertices correspond to players, and a player can see each player to whom she or he is connected by an arc. The team wins if at least one player guesses his hat color correctly, and no one guesses his hat color wrong; otherwise the team loses. The team aims to maximize the probability of a win, and this maximum is called the hat number of the graph. Previous works focused on the problem on complete graphs and on undirected graphs. Some cases were solved, e.g., complete graphs of certain orders, trees, cycles, bipartite graphs. These led Uriel Feige to conjecture that the hat number of any graph is equal to the hat number of its maximum clique. We show that the conjecture does not hold for...

  12. Long-term surveillance plan for the Mexican Hat disposal site Mexican Hat, Utah

    This long-term surveillance plan (LTSP) describes the U.S. Department of Energy's (DOE) long-term care program for the Uranium Mill Tailings Remedial Action (UMTRA) Project Mexican Hat, Utah, disposal site. The U.S. Nuclear Regulatory Commission (NRC) has developed regulations for the issuance of a general license for the custody and long-term care of UMTRA Project disposal sites in 10 CFR Part 40. The purpose of this general license is to ensure that the UMTRA Project disposal sites will be cared for in a manner that protects the public health and safety and the environment. Before each disposal site is licensed, the NRC requires the DOE to submit a site-specific LTSP. The DOE prepared this LTSP to meet this requirement for the Mexican Hat disposal site. The general license becomes effective when the NRC concurs with the DOE's determination of completion of remedial action for the disposal site and the NRC formally accepts this LTSP. This LTSP describes the long-term surveillance program the DOE will implement to ensure that the Mexican Hat disposal site performs as designed. The program is based on two distinct types of activities: (1) site inspections to identify potential threats to disposal cell integrity, and (2) monitoring of selected seeps to observe changes in flow rates and water quality. The LTSP is based on the UMTRA Project long-term surveillance program guidance and meets the requirements of 10 CFR section 40.27(b) and 40 CFR section 192.03. 18 refs., 6 figs., 1 tab

  13. Disubstituted naphthyl β-D-xylopyranosides: Synthesis, GAG priming, and histone acetyltransferase (HAT) inhibition.

    Thorsheim, Karin; Persson, Andrea; Siegbahn, Anna; Tykesson, Emil; Westergren-Thorsson, Gunilla; Mani, Katrin; Ellervik, Ulf

    2016-04-01

    Xylosides are a group of compounds that can induce glycosaminoglycan (GAG) chain synthesis independently of a proteoglycan core protein. We have previously shown that the xyloside 2-(6-hydroxynaphthyl)β-D-xylopyranoside has a tumor-selective growth inhibitory effect both in vitro and in vivo, and that the effect in vitro was correlated to a reduction in histone H3 acetylation. In addition, GAG chains have previously been reported to inhibit histone acetyltransferases (HAT). To investigate if xylosides, or the corresponding xyloside-primed GAG chains, can be used as HAT inhibitors, we have synthesized a series of naphthoxylosides carrying structural motifs similar to the aromatic moieties of the known HAT inhibitors garcinol and curcumin, and studied their biological activities. Here, we show that the disubstituted naphthoxylosides induced GAG chain synthesis, and that the ones with at least one free phenolic group exhibited moderate HAT inhibition in vitro, without affecting histone H3 acetylation in cell culture. The xyloside-primed GAG chains, on the other hand, had no effect on HAT activity, possibly explaining why the effect of the xylosides on histone H3 acetylation was absent in cell culture as the xylosides were recruited for GAG chain synthesis. Further investigations are required to find xylosides that are effective HAT inhibitors or xylosides producing GAG chains with HAT inhibitory effects. PMID:27023911

  14. In Vitro Progression of HPV16 Episome-Associated Cervical Neoplasia Displays Fundamental Similarities to Integrant-Associated Carcinogenesis

    Gray, Elizabeth; Pett, Mark R; Ward, Dawn; Winder, David M; Stanley, Margaret A; Roberts, Ian; Scarpini, Cinzia G.; Coleman, Nicholas

    2010-01-01

    An important event in the development of cervical squamous cell carcinoma (SCC) is deregulated expression of high-risk human papillomavirus (HR-HPV) oncogenes, most commonly related to viral integration into host DNA. Mechanisms of development of the ~15% of SCCs that contain extra-chromosomal (episomal) HR-HPV are poorly understood, due to limited longitudinal data. We therefore employed the W12 model to study mechanisms of cervical carcinogenesis associated with episomal HPV16. In vitro pro...

  15. Final report. Human artificial episomal chromosome (HAEC) for building large genomic libraries

    Jean-Michael H. Vos

    1999-12-09

    Collections of human DNA fragments are maintained for research purposes as clones in bacterial host cells. However for unknown reasons, some regions of the human genome appear to be unclonable or unstable in bacteria. Their team has developed a system using episomes (extrachromosomal, autonomously replication DNA) that maintains large DNA fragments in human cells. This human artificial episomal chromosomal (HAEC) system may prove useful for coverage of these especially difficult regions. In the broader biomedical community, the HAEC system also shows promise for use in functional genomics and gene therapy. Recent improvements to the HAEC system and its application to mapping, sequencing, and functionally studying human and mouse DNA are summarized. Mapping and sequencing the human genome and model organisms are only the first steps in determining the function of various genetic units critical for gene regulation, DNA replication, chromatin packaging, chromosomal stability, and chromatid segregation. Such studies will require the ability to transfer and manipulate entire functional units into mammalian cells.

  16. HATS-22b, HATS-23b and HATS-24b: Three new transiting Super-Jupiters from the HATSouth Project

    Bento, Joao; Hartman, Joel; Bakos, Gaspar; Ciceri, Simona; Brahm, Rafael; Bayliss, Daniel; Espinoza, Nestor; Zhou, George; Rabus, Markus; Bhatti, Waqas; Penev, Kaloyan; Csubry, Zoltan; Jordan, Andres; Mancini, Luigi; Henning, Thomas; de Val-Borro, Miguel; Tinney, Chris; Wright, Duncan; Suc, Vincent; Noyes, Robert; Lazar, Jozsef; Papp, Istvan; Sari, Pal

    2016-01-01

    We report the discovery of three moderately high-mass transiting hot Jupiters from the HATSouth survey: HATS-22b, HATS-23b and HATS-24b. These planets add to the numbers of known planets in the ~2MJ regime. HATS-22b is a 2.74+/-0.11 MJ mass and 0.953+0.048/-0.029 RJ radius planet orbiting a V = 13.455 +/- 0.040 sub-silar mass (M_star = 0.759+/-0.019 M_sun; R_star = 0.759+/-0.019 R_sun) K-dwarf host star on an eccentric (e = 0.079 +/- 0.026) orbit. This planet's high planet-to-stellar mass ratio is further evidence that migration mechanisms for hot Jupiters may rely on exciting orbital eccentricities that bring planets closer to their parent stars followed by tidal circularisation. HATS-23b is a 1.478 +/- 0.080 MJ mass and 1.69 +/- 0.24 RJ radius planet on a grazing orbit around a V = 13.901 +/- 0.010 G-dwarf with properties very similar to those of the Sun (M_star = 1.115 +/- 0.054 M_sun; R_star = 1.145 +/- 0.070 R_sun). HATS-24b orbits a moderately bright V = 12.830 +/- 0.010 F-dwarf star (M_star = 1.218 +/-...

  17. "Work smart, wear your hard hat"

    2003-01-01

    Falling objects and collisions are frequent occurrences in work sites and hazardous areas. Hard hats can help prevent many types of accident and can even save lives. Just imagine an 800 g spanner falling from a 13 m high scaffold onto the head of someone standing below - a nightmare scenario! The impact to the head is equivalent to that of a 5 kg weight falling from 2 metres. That is just what happened to Gerd Fetchenhauer when he was working on the UA1 experiment. Fortunately, he was wearing a hard hat at the time. "That hat saved my life," he explains. "It punched a hole right through the hat and I was a bit dazed for a couple of hours but otherwise I was OK." Since that day, Gerd Fetchenhauer, now working on CMS, is never seen on a work site without his hard hat on. Work sites have proliferated at CERN with the construction of the LHC and its detectors, and the wearing of hard hats is compulsory (not to mention life-saving). In the underground caverns and experiment halls, where gantry cranes and other h...

  18. Long-term surveillance plan for the Mexican Hat Disposal Site, Mexican Hat, Utah

    This plan describes the long-term surveillance activities for the Uranium Mill Tailings Remedial Action (UMTRA) Project disposal site at Mexican Hat, Utah. The U.S. Department of Energy (DOE) will carry out these activities to ensure that the disposal site continues to function as designed. This long-term surveillance plan (LTSP) was prepared as a requirement for acceptance under the U.S. Nuclear Regulatory Commission (NRC) general license for custody and long-term care of residual radioactive material (RRM). This LTSP (based on the DOE's Guidance for Implementing the UMTRA Project Long-term Surveillance Program), documents the land ownership interests and details how the long-term care of the disposal site will be accomplished

  19. Long-term surveillance plan for the Mexican Hat Disposal Site, Mexican Hat, Utah

    NONE

    1996-02-01

    This plan describes the long-term surveillance activities for the Uranium Mill Tailings Remedial Action (UMTRA) Project disposal site at Mexican Hat, Utah. The U.S. Department of Energy (DOE) will carry out these activities to ensure that the disposal site continues to function as designed. This long-term surveillance plan (LTSP) was prepared as a requirement for acceptance under the U.S. Nuclear Regulatory Commission (NRC) general license for custody and long-term care of residual radioactive material (RRM). This LTSP (based on the DOE`s Guidance for Implementing the UMTRA Project Long-term Surveillance Program), documents the land ownership interests and details how the long-term care of the disposal site will be accomplished.

  20. Physical and Functional HAT/HDAC Interplay Regulates Protein Acetylation Balance

    Alessia Peserico; Cristiano Simone

    2011-01-01

    The balance between protein acetylation and deacetylation controls several physiological and pathological cellular processes, and the enzymes involved in the maintenance of this equilibrium—acetyltransferases (HATs) and deacetylases (HDACs)—have been widely studied. Presently, the evidences obtained in this field suggest that the dynamic acetylation equilibrium is mostly maintained through the physical and functional interplay between HAT and HDAC activities. This model overcomes the classica...

  1. On the hat problem, its variations, and their applications

    Marcin Piotr Krzywkowski

    2010-03-01

    Full Text Available The topic of our paper is the hat problem in which each of n players is randomly fitted with a blue or red hat. Then everybody can try to guess simultaneously his own hat color by looking at the hat colors of the other players. The team wins if at least one player guesses his hat color correctly, and no one guesses his hat color wrong; otherwise the team loses. The aim is to maximize the probability of a win. There are known many variations of the hat problem. In this paper we give a comprehensive list of variations considered in the literature. We describe the applications of the hat problem and its variations, and their connections to different areas of science. We give the full bibliography of any papers, books, and electronic publications about the hat problem.

  2. Human Papilloma Viral DNA Replicates as a Stable Episome in Cultured Epidermal Keratinocytes

    Laporta, Robert F.; Taichman, Lorne B.

    1982-06-01

    Human papilloma virus (HPV) is poorly understood because systems for its growth in tissue culture have not been developed. We report here that cultured human epidermal keratinocytes could be infected with HPV from plantar warts and that the viral DNA persisted and replicated as a stable episome. There were 50-200 copies of viral DNA per cell and there was no evidence to indicate integration of viral DNA into the cellular genome. There was also no evidence to suggest that viral DNA underwent productive replication. We conclude that cultured human epidermal keratinocytes may be a model for the study of certain aspects of HPV biology.

  3. HATS-31b Through HATS-35b: Five Transiting Hot Jupiters Discovered by the HATSouth Survey

    de Val-Borro, M; Brahm, R; Hartman, J D; Espinoza, N; Penev, K; Ciceri, S; Jordán, A; Bhatti, W; Csubry, Z; Bayliss, D; Bento, J; Zhou, G; Rabus, M; Mancini, L; Henning, T; Schmidt, B; Tan, T G; Tinney, C G; Wright, D J; Kedziora-Chudczer, L; Bailey, J; Suc, V; Lázár, J; Papp, I; Sári, P

    2016-01-01

    We report the discovery of five new transiting hot Jupiter planets discovered by the HATSouth survey: HATS-31b through HATS-35b. These planets orbit moderately bright stars with V magnitudes within the range 11.9-14.4mag while the planets span a range of masses 0.88-1.22MJ, and have somewhat inflated radii between 1.23-1.64RJ.These planets can be classified as typical hot Jupiters, with HATS-31b and HATS-35b being moderately inflated gas giant planets with radii of $1.64 \\pm 0.22$ RJ and 1.464+0.069-0.044RJ, respectively, that can be used to constrain inflation mechanisms. All five systems present a higher Bayesian evidence for a fixed circular orbit model than for an eccentric orbit. The orbital periods range from $1.8209993 \\pm 0.0000016$ day for HATS-35b) to $3.377960 \\pm 0.000012$ day for HATS-31b. Additionally, HATS-35b orbits a relatively young F star with an age of $2.13 \\pm 0.51$ Gyr. We discuss the analysis to derive the properties of these systems and compare them in the context of the sample of wel...

  4. Limitations of Short Range Mexican Hat Connection for Driving Target Selection in a 2D Neural Field: Activity Suppression and Deviation from Input Stimuli.

    Geoffrey eMégardon

    2015-10-01

    Full Text Available Dynamic Neural Field models (DNF often use a kernel of connection with short range excitation and long range inhibition. This organization has been suggested as a model for brain structures or for artificial systems involved in winner-take-all processes such as saliency localisation, perceptual decision or target/action selection. A good example of such a DNF is the superior colliculus (SC, a key structure for eye movements. Recent results suggest that the superficial layers of the SC (SCs exhibit relatively short range inhibition with a longer time constant than excitation. The aim of the present study was to further examine the properties of a DNF with such an inhibition pattern in the context of target selection. First we tested the effects of stimulus size and shape on when and where self-maintained clusters of firing neurons appeared, using three variants of the model. In each model variant, small stimuli led to rapid formation of a spiking cluster, a range of medium sizes led to the suppression of any activity on the network and hence to no target selection, while larger sizes led to delayed selection of multiple loci. Second, we tested the model with two stimuli separated by a varying distance. Again single, none, or multiple spiking clusters could occur, depending on distance and relative stimulus strength. For short distances, activity attracted towards the strongest stimulus, reminiscent of well-known behavioural data for saccadic eye movements, while for larger distances repulsion away from the second stimulus occurred. All these properties predicted by the model suggest that the SCs, or any other neural structure thought to implement a short range MH, is an imperfect winner-take-all system. Although those properties call for systematic testing, the discussion gathers neurophysiological and behavioural data suggesting that such properties are indeed present in target selection for saccadic eye movements.

  5. James J. Gallagher: Man in the White Hat

    Jolly, Jennifer L.; Robinson, Ann

    2014-01-01

    In classic Western movies, the good guy could be frequently identified by his trademark white Stetson hat, whereas the bad guy always wore black. James J. Gallagher wore many hats during his career that spanned over six decades; he too would be known as the "man in the white hat,"--trusted to do the right thing. From 1967 to 1970,…

  6. In vivo reinsertion of excised episomes by the V(DJ recombinase: a potential threat to genomic stability.

    Katrina Vanura

    2007-03-01

    Full Text Available It has long been thought that signal joints, the byproducts of V(DJ recombination, are not involved in the dynamics of the rearrangement process. Evidence has now started to accumulate that this is not the case, and that signal joints play unsuspected roles in events that might compromise genomic integrity. Here we show both ex vivo and in vivo that the episomal circles excised during the normal process of receptor gene rearrangement may be reintegrated into the genome through trans-V(DJ recombination occurring between the episomal signal joint and an immunoglobulin/T-cell receptor target. We further demonstrate that cryptic recombination sites involved in T-cell acute lymphoblastic leukemia-associated chromosomal translocations constitute hotspots of insertion. Eventually, the identification of two in vivo cases associating episomal reintegration and chromosomal translocation suggests that reintegration events are linked to genomic instability. Altogether, our data suggest that V(DJ-mediated reintegration of episomal circles, an event likely eluding classical cytogenetic screenings, might represent an additional potent source of genomic instability and lymphoid cancer.

  7. Comparative metabolism of benzo[a]pyrene by human keratinocytes infected with high-risk human papillomavirus types 16 and 18 as episomal or integrated genomes

    Neil Trushin

    2012-01-01

    Full Text Available Background: Infection with human papillomavirus (HPV is a critical factor in the development of cervical cancer. Smoking is an additional risk factor. Tobacco smoke carcinogens, such as benzo[a]pyrene (B[a]P, and their cytochrome P450-related metabolites are present in significantly higher levels in the cervical mucus of women smokers than in nonsmokers. We determined the metabolism and P450 expression of B[a]P-treated human keratinocytes infected with HPV-16 or -18. Materials and Methods: Monolayer cultures of uninfected primary human foreskin keratinocytes, human vaginal and cervical keratinocytes carrying episomal genomes of HPV-16 and -18, respectively, and invasive cervical carcinoma cell lines carrying either HPV-16 or -18 genomes integrated into the host DNA, were incubated with 0.1 μM [3H]B[a]P. The resulting oxidative metabolites were analyzed and quantified by radioflow high-performance liquid chromatography. Additionally, all cell lines were incubated with unlabeled 0.1 μM B[a]P for Western blot analysis of cytochrome P450 1A1 and 1B1. Results: Significant enhancement in levels of both detoxification and activation metabolites was found in incubations with all types of HPV-infected cells compared with control incubations (P < 0.05. The highest capacity to metabolize B[a]P was observed with cells containing integrated HPV-18 genomes. Induction of cytochrome 1B1 was observed in HPV-16 and -18 integrated, and in HPV-16 episomal cell types. Conclusions: Both viral genotype and genomic status in the host cell affect B[a]P metabolism and cytochrome P450 1B1 expression. An increase of DNA-damaging metabolites might result from exposure of HPV-infected women to cigarette smoke carcinogens.

  8. Targeting Specific HATs for Neurodegenerative Disease Treatment: Translating Basic Biology to Therapeutic Possibilities

    Sheila K. Pirooznia

    2013-03-01

    Full Text Available Dynamic epigenetic regulation of neurons is emerging as a fundamental mechanism by which neurons adapt their transcriptional responses to specific developmental and environmental cues. While defects within the neural epigenome have traditionally been studied in the context of early developmental and heritable cognitive disorders, recent studies point to aberrant histone acetylation status as a key mechanism underlying acquired inappropriate alterations of genome structure and function in post-mitotic neurons during the aging process. Indeed, it is becoming increasingly evident that chromatin acetylation status can be impaired during the lifetime of neurons through mechanisms related to loss of function of histone acetyltransferase (HATs activity. Several HATs have been shown to participate in vital neuronal functions such as regulation of neuronal plasticity and memory formation. As such, dysregulation of such HATs has been implicated in the pathogenesis associated with age-associated neurodegenerative diseases and cognitive decline. In order to counteract the loss of HAT function in neurodegenerative diseases, the current therapeutic strategies involve the use of small molecules called histone deacetylase (HDAC inhibitors that antagonize HDAC activity and thus enhance acetylation levels. Although this strategy has displayed promising therapeutic effects, currently used HDAC inhibitors lack target specificity, raising concerns about their applicability. With rapidly evolving literature on HATs and their respective functions in mediating neuronal survival and higher order brain function such as learning and memory, modulating the function of specific HATs holds new promises as a therapeutic tool in neurodegenerative diseases. In this review, we focus on the recent progress in research regarding epigenetic histone acetylation mechanisms underlying neuronal activity and cognitive function. We discuss the current understanding of specific HDACs and

  9. Long-term surveillance plan for the Mexican Hat disposal site Mexican Hat, Utah

    This long-term surveillance plan (LTSP) describes the U.S. Department of Energy's (DOE) long-term care program for the Uranium Mill Tailings Remedial Action (UMTRA) Project Mexican Hat, Utah, disposal site. This LSTP describes the long-term surveillance program the DOE will implement to ensure the Mexican Hat disposal site performs as designed and is cared for in a manner that protects the public health and safety and the environment. Before each disposal site is licensed for custody and long-term care, the Nuclear Regulatory Commission (NRC) requires the DOE to submit such a site-specific LTSP

  10. Radiologic characterization of the Mexican Hat, Utah, uranium mill tailings remedial action site: Addendum D1

    Ludlam, J.R.

    1985-01-01

    This radiologic characterization of the inactive uranium millsite at Mexican Hat, Utah, was conducted by Bendix Field Engineering Corporation for the US Department of Energy (DOE), Grand Junctions Project Office in response to and in accord with a Statement of Work prepared by the DOE Uranium Mill Tailings Remedial Action Project (UMTRAP) Technical Assistance Contractor, Jacobs Engineering Group, Inc. The objective of this project was to determine the horizontal and vertical extent of contamination that exceeds the US Environmental Protection Agency (EPA) standards at the Mexican Hat site. The data presented in this report are required for characterization of the areas adjacent to the Mexican Hat tailings piles and for the subsequent design of cleanup activities. Some on- pile sampling was required to determine the depth of the 15-pCi/g Ra- 226 interface in an area where wind and water erosion has taken place.

  11. HATS-25b through HATS-30b: A Half-dozen New Inflated Transiting Hot Jupiters from the HATSouth Survey

    Espinoza, N; Hartman, J D; Bakos, G Á; Jordán, A; Zhou, G; Mancini, L; Brahm, R; Ciceri, S; Bhatti, W; Csubry, Z; Rabus, M; Penev, K; Bento, J; de Val-Borro, M; Henning, T; Schmidt, B; Suc, V; Wright, D J; Tinney, C G; Tan, T G; Noyes, R

    2016-01-01

    We report six new inflated hot Jupiters (HATS-25b through HATS-30b) discovered using the HATSouth global network of automated telescopes. The planets orbit stars with $V$ magnitudes in the range $\\sim 12-14$ and have masses in the largely populated $0.5M_J-0.7M_J$ region of parameter space but span a wide variety of radii, from $1.17R_J$ to $1.75 R_J$. HATS-25b, HATS-28b, HATS-29b and HATS-30b are typical inflated hot Jupiters ($R_p = 1.17-1.26R_J$) orbiting G-type stars in short period ($P=3.2-4.6$ days) orbits. However, HATS-26b ($R_p = 1.75R_J$, $P = 3.3024$ days) and HATS-27b ($R_p=1.50R_J$, $P=4.6370$ days) stand out as highly inflated planets orbiting slightly evolved F stars just after and in the turn-off points, respectively, which are among the least dense hot Jupiters, with densities of $0.153$ g cm$^{-3}$ and $0.180$ g cm$^{-3}$, respectively. All the presented exoplanets but HATS-27b are good targets for future atmospheric characterization studies, while HATS-27b is a prime target for Rossiter-McL...

  12. Research on Prehistoric Hats in Xinjiang (2000 BC-200 BC)

    Xiaoyu Xin

    2015-01-01

    Based on archaeological evidence, this paper analyzes hats unearthed from prehistoric Xinjiang. Three typicalcategories of ancient hats can be recognized according to different styles and structures. And each of themrepresents the local dressing culture of different geographical areas of Xinjiang. Meanwhile, the similaritiesbetween prehistoric hats from Xinjiang and other Ancient tombs in Eurasia indicate early culturalcommunications between different civilizations from the Bronze Age to the ...

  13. Stable transformation of an episomal protein-tagging shuttle vector in the piscine diplomonad Spironucleus vortens

    Cronembold Daniela

    2008-04-01

    Full Text Available Abstract Background Diplomonads are common free-living inhabitants of anoxic aquatic environments and are also found as intestinal commensals or parasites of a wide variety of animals. Spironucleus vortens is a putatively commensal diplomonad of angelfish that grows to high cell densities in axenic culture. Genomic sequencing of S. vortens is in progress, yet little information is available regarding molecular and cellular aspects of S. vortens biology beyond descriptive ultrastructural studies. To facilitate the development of S. vortens as an additional diplomonad experimental model, we have constructed and stably transformed an episomal plasmid containing an enhanced green fluorescent protein (GFP tag, an AU1 epitope tag, and a tandem affinity purification (TAP tag. This construct also contains selectable antibiotic resistance markers for both S. vortens and E. coli. Results Stable transformants of S. vortens grew relatively rapidly (within 7 days after electroporation and were maintained under puromycin selection for over 6 months. We expressed the enhanced GFP variant, eGFP, under transcriptional control of the S. vortens histone H3 promoter, and visually confirmed diffuse GFP expression in over 50% of transformants. Next, we generated a histone H3::GFP fusion using the S. vortens conventional histone H3 gene and its native promoter. This construct was also highly expressed in the majority of S. vortens transformants, in which the H3::GFP fusion localized to the chromatin in both nuclei. Finally, we used fluorescence in situ hybridization (FISH of the episomal plasmid to show that the transformed plasmid localized to only one nucleus/cell and was present at roughly 10–20 copies per nucleus. Because S. vortens grows to high densities in laboratory culture, it is a feasible diplomonad from which to purify native protein complexes. Thus, we also included a TAP tag in the plasmid constructs to permit future tagging and subsequent purification

  14. HAT-P-20b--HAT-P-23b: Four Massive Transiting Extrasolar Planets

    Bakos, G Á; Torres, G; Latham, D W; Kovács, Géza; Noyes, R W; Fischer, D A; Johnson, J A; Marcy, G W; Howard, A W; Kipping, D; Esquerdo, G A; Shporer, A; Béky, B; Buchhave, L A; Perumpilly, G; Everett, M; Sasselov, D D; Stefanik, R P; Lázár, J; Papp, I; Sári, P

    2010-01-01

    We report the discovery of four relatively massive (2-7MJ) transiting extrasolar planets. HAT-P-20b orbits a V=11.339 K3 dwarf star with a period P=2.875317+/-0.000004d. The host star has a mass of 0.760+/-0.03 Msun, radius of 0.690+/-0.02 Rsun, Teff=4595+/-80 K, and metallicity [Fe/H]=+0.35+/-0.08. HAT-P-20b has a mass of 7.246+/-0.187 MJ, and radius of 0.867+/-0.033 RJ yielding a mean density of 13.78+/-1.50 gcm^-3 , which is the second highest value among all known exoplanets. HAT-P-21b orbits a V=11.685 G3 dwarf on an eccentric (e=0.2280+/-0.016) orbit, with a period of P=4.1244810+/-000007d. The host star has a mass of 0.95+/-0.04Msun, radius of 1.10+/-0.08Rsun, Teff=5588+/-80K, and [Fe/H]=+0.01+/-0.08. HAT-P-21b has a mass of 4.063+/-0.161MJ, and radius of 1.024+/-0.092RJ. HAT-P-22b orbits the V=9.732 G5 dwarf HD233731, with P=3.2122200+/-0.000009d. The host star has a mass of 0.92+/-0.03Msun, radius of 1.04+/-0.04Rsun, Teff=5302+/-80K, and metallicity of +0.24+/-0.08. The planet has a mass of 2.147+/-0...

  15. Engineering assessment of inactive uranium mill tailings: Mexican Hat Site, Mexican Hat, Utah

    Ford, Bacon and Davis Utah Inc. has reevaluated the Mexican Hat site in order to revise the March 1977 engineering assessment of the problems resulting from the existence of radioactive uranium mill tailings at Mexican Hat, Utah. This engineering assessment has included the preparation of topographic maps, the performance of core drillings and radiometric measurements sufficient to determine areas and volumes of tailings and radiation exposures of individuals and nearby populations, the investigations of site hydrology and meteorology, and the evaluation and costing of alternative corrective actions. Radon gas released from the 2.2 million tons of tailings at the Mexican Hat site constitutes the most significant environmental impact, although windblown tailings and external gamma radiation also are factors. The four alternative actions presented in this engineering assessment range from millsite decontamination with the addition of 3 m of stabilization cover material to removal of the tailings to remote disposal sites and decontamination of the tailings site. Cost estimates for the four options range from about $15,200,000 for stabilization in place, to about $45,500,000 for disposal at a distance of about 16 mi. Three principal alternatives for the reprocessing of the Mexican Hat tailings were examined: heap leaching; treatment at an existing mill; and reprocessing at a new conventional mill constructed for tailings reprocessing. The cost of the uranium recovered would be about $115/lb of U3O8 whether by heap leach or conventional plant processes. The spot market price for uranium was $25/lb early in 1981. Reprocessing the Mexican Hat tailings for uranium recovery is not economically attractive under present conditions

  16. Engineering assessment of inactive uranium mill tailings: Mexican Hat Site, Mexican Hat, Utah

    None

    1981-09-01

    Ford, Bacon and Davis Utah Inc. has reevaluated the Mexican Hat site in order to revise the March 1977 engineering assessment of the problems resulting from the existence of radioactive uranium mill tailings at Mexican Hat, Utah. This engineering assessment has included the preparation of topographic maps, the performance of core drillings and radiometric measurements sufficient to determine areas and volumes of tailings and radiation exposures of individuals and nearby populations, the investigations of site hydrology and meteorology, and the evaluation and costing of alternative corrective actions. Radon gas released from the 2.2 million tons of tailings at the Mexican Hat site constitutes the most significant environmental impact, although windblown tailings and external gamma radiation also are factors. The four alternative actions presented in this engineering assessment range from millsite decontamination with the addition of 3 m of stabilization cover material to removal of the tailings to remote disposal sites and decontamination of the tailings site. Cost estimates for the four options range from about $15,200,000 for stabilization in place, to about $45,500,000 for disposal at a distance of about 16 mi. Three principal alternatives for the reprocessing of the Mexican Hat tailings were examined: heap leaching; treatment at an existing mill; and reprocessing at a new conventional mill constructed for tailings reprocessing. The cost of the uranium recovered would be about $115/lb of U/sub 3/O/sub 8/ whether by heap leach or conventional plant processes. The spot market price for uranium was $25/lb early in 1981. Reprocessing the Mexican Hat tailings for uranium recovery is not economically attractive under present conditions.

  17. Genetic modification of cancer cells using non-viral, episomal S/MAR vectors for in vivo tumour modelling.

    Orestis Argyros

    Full Text Available The development of genetically marked animal tumour xenografts is an area of ongoing research to enable easier and more reliable testing of cancer therapies. Genetically marked tumour models have a number of advantages over conventional tumour models, including the easy longitudinal monitoring of therapies and the reduced number of animals needed for trials. Several different methods have been used in previous studies to mark tumours genetically, however all have limitations, such as genotoxicity and other artifacts related to the usage of integrating viral vectors. Recently, we have generated an episomally maintained plasmid DNA (pDNA expression system based on Scaffold/Matrix Attachment Region (S/MAR, which permits long-term luciferase transgene expression in the mouse liver. Here we describe a further usage of this pDNA vector with the human Ubiquitin C promoter to create stably transfected human hepatoma (Huh7 and human Pancreatic Carcinoma (MIA-PaCa2 cell lines, which were delivered into "immune deficient" mice and monitored longitudinally over time using a bioluminometer. Both cell lines revealed sustained episomal long-term luciferase expression and formation of a tumour showing the pathological characteristics of hepatocellular carcinoma (HCC and pancreatic carcinoma (PaCa, respectively. This is the first demonstration that a pDNA vector can confer sustained episomal luciferase transgene expression in various mouse tumour models and can thus be readily utilised to follow tumour formation without interfering with the cellular genome.

  18. Utilization of a thermosensitive episome bearing transposon TN10 to isolate Hfr donor strains of Erwinia carotovora subsp. chrysanthemi.

    Kotoujansky, A; Lemattre, M; Boistard, P

    1982-04-01

    A thermosensitive episome bearing the transposon Tn10, F(Ts)::Tn10 Lac+, has been successfully transferred from Escherichia coli to several wild strains of the enterobacteria Erwinia carotovora subsp. chrysanthemi, which are pathogenic on Saintpaulia ionantha. In one of these strains, all of the characters controlled by this episome (Lac+, Tetr, Tra+) were expressed, and its replication was stopped at 40 degrees C and above. At 30 degrees C, the episome was easily transferred between strains derived from E. carotovora subsp. chrysanthemi 3937j and to E coli. Hfr donor strains were obtained from a F' strain of 3937j by selecting clones which grew at 40 degrees C on plates containing tetracycline. One of these strains, Hfrq, was examined in more detail: the characters Lac+ and Tetr were stabilized and did not segregate higher than its parental F' strain. The mating was most efficient at 37 degrees C on a membrane. Hfrq transferred its chromosome to recipient strains at high frequency and in a polarized fashion, as evidenced by the gradient of transfer frequencies, the kinetics of marker entry (in interrupted mating experiments), and the analysis of linkage between different markers. The chromosome of Hfrq was most probably transferred in the following sequence: origin...met...xyl...arg...ile...leu...thr...cys...pan...ura...gal...trp...his. ..pur... Moreover, this genetic transfer system proved to be efficient in strain construction. PMID:6277860

  19. Isotope techniques on groundwater contamination studies in urbanized and industrialized areas, Hat Yai Basin

    Anthropogenic activities are of a major force in changing the hydrological cycle as well as the climate warming. Assessing the impacts of human activities on hydrological environments is becoming a wide-focused topic. In this research, the authors attempt to link the urbanization, agricultural development, and the subsequent water resources exploitation with the change of water environments in Hat Yai basin, southern of Thailand. The source of water for domestic use mainly comes from Utapao River which flows through the area. Now this area is facing the shortage of water in dry season and pollution due to domestic and industrial activities. Isotope techniques in conjunction with hydrological and chemical data can play the important role for identifying recharge zone, flow dynamic, recharge mechanism and surface and groundwater interaction. By using the numerical model the information for proper groundwater management, can be obtained. As a result, the quality of ground water in Hat Yai basin was show that the quality of iron (Fe) was higher than Notification of the Ministry of Industry permissible level for groundwater quality standards for drinking purposes at many locations. Groundwater in many locations should not use to drinking water. The water types of Hat Yai Aquifer were Na-Cl and Ca-HCO3. The water type of Kliu Tao aquifer was Ca-Mg-HCO3 and Kho Hong aquifer was Ca-Mg-HCO3. The Origin of groundwater in Hat Yai aquifer is local rainfall. The Origin of groundwater in Khu Tao and Kho Hong aquifer come from ancient rainfall.The ground water from Khu Tao and Kho Hong aquifer were old water and low flow rate. The recharge zone was located west and east of Hat Yai Basin. After that the groundwater will flow to middle basin and northward to Songkhla Lake. (author)

  20. Isotope techniques in groundwater contamination studies in urbanized and industrialized areas, Hat Yai Basin

    Anthropogenic activities are mainly responsible for changing the hydrological cycle as well as the climate warming. Assessing the impacts of human activities on hydrological environments is becoming a wide-focused topic. In this research, the author attempt to link the urbanization, agricultural development, and the subsequent water resources exploitation with the change of water environments in Hat Yai Basin, southern of Thailand. The source of water for domestic use mainly comes from Utapao River which flows through the area. Now this area is facing the shortage of water in dry season and pollution due to domestic and industrial activities. Isotope techniques in conjunction with hydrological and chemical data can play the important role for identifying recharge mechanism and surface and groundwater interaction. By using the numerical model the information for proper groundwater management can be obtained. As a result, the quality of groundwater in Hat Yai Basin showed that the iron (Fe) content at many locations was higher than the permissible level for groundwater quality standards for drinking purposes in the Notification of the Ministry of Industry. Groundwater from such locations should not be used for drinking. The water types of Hat Yai aquifer were Na-Cl and Ca-HCO3, while that of Khu Tao aquifer and Kho Hong aquifer were CA-Mg-HCO3 and Ca-Mg-HCO3, respectively. The origin of groundwater in Hat Yai aquifer is local rainfall. The origin of groundwater in Khu Tao and Kho Hong aquifers come from ancient rainfall indicating old water and low flow rate. The groundwater is recharged from the zones located in the eastern and western parts of Hat Yai Basin and flows to middle basin and northward to Songkhla Lake. (author)

  1. UMTRA Project Site Observational Work Plan, Mexican Hat, Utah

    1994-09-01

    Surface cleanup activities at the Mexican Hat UMTRA processing site are nearing completion. Ground Water contamination at the Mexican Hat site is a result of uranium milling operations. The extent of residual process water has been identified, and it is limited to the uppermost aquifer in the vicinity of the site. Deeper aquifers are not affected because of an upward hydraulic gradient and the presence of a confining unit (the deeper aquifers are protected by hydrogeologic isolation). The uppermost unit is returning to its pre-milling, mainly unsaturated state. The unit that contains the contaminated water is not a ground water resource because it qualifies as Class III (limited use) based on limited yield. Ground water in the uppermost unit is currently not used and is not anticipated to be used as a ground water resource. The nearby San Juan River and a converted oil exploration well provide all of the water needs for the area. There are no current threats to human health or livestock; and, because the zone of contamination does not represent a ground water resource, none are anticipated in the future. There are, however, seeps where contaminated water is exposed at land surface. The seeps create potential exposure pathways for plants and wildlife. It is not known at this time if there is a risk to the environment. Additional investigations are needed and are described in this document to confirm the presence or absence of potential environmental risks. Additional hydrogeologic investigations are not required. The proposed ground water compliance strategy for the site is no remediation, because the ground water in the uppermost aquifer (which is also the zone of contamination) qualifies for supplemental standards based on Class III, limited yield, and because there are no threats to human health. Domestic and agricultural water is pumped from a deeper aquifer that is isolated from the contaminated zone.

  2. UMTRA Project Site Observational Work Plan, Mexican Hat, Utah

    Surface cleanup activities at the Mexican Hat UMTRA processing site are nearing completion. Ground Water contamination at the Mexican Hat site is a result of uranium milling operations. The extent of residual process water has been identified, and it is limited to the uppermost aquifer in the vicinity of the site. Deeper aquifers are not affected because of an upward hydraulic gradient and the presence of a confining unit (the deeper aquifers are protected by hydrogeologic isolation). The uppermost unit is returning to its pre-milling, mainly unsaturated state. The unit that contains the contaminated water is not a ground water resource because it qualifies as Class III (limited use) based on limited yield. Ground water in the uppermost unit is currently not used and is not anticipated to be used as a ground water resource. The nearby San Juan River and a converted oil exploration well provide all of the water needs for the area. There are no current threats to human health or livestock; and, because the zone of contamination does not represent a ground water resource, none are anticipated in the future. There are, however, seeps where contaminated water is exposed at land surface. The seeps create potential exposure pathways for plants and wildlife. It is not known at this time if there is a risk to the environment. Additional investigations are needed and are described in this document to confirm the presence or absence of potential environmental risks. Additional hydrogeologic investigations are not required. The proposed ground water compliance strategy for the site is no remediation, because the ground water in the uppermost aquifer (which is also the zone of contamination) qualifies for supplemental standards based on Class III, limited yield, and because there are no threats to human health. Domestic and agricultural water is pumped from a deeper aquifer that is isolated from the contaminated zone

  3. Monitoring of BTX by passive sampling in Hat Yai

    Proespichaya Kanatharana

    2004-02-01

    Full Text Available Laboratory-built passive samplers were used for monitoring of trace benzene, toluene and xylene (BTX in Hat Yai from 28 July to 12 August, 2003. Sampler bottles contained activated Tenax TA 60/80 meshand a lab-built thermal well were developed and evaluated for the sampling and analysis of BTX. The sampling was carried out for two weeks before the passive samplers were thermally desorbed, trapped ina sampling loop by a laboratory built purge and trap system and analysed by gas chromatography (GC equipped with a flame ionization detector. After optimization and calibration, the developed method showed high selectivity, a good sensitivity with detection limits for BTX of 0.8, 1.1 and 13.0 µg/m3 respectively and an acceptable precision. Ambient BTX measurements were conducted at many monitoring site i.e. hot spots (high exposure, residential areas/work places (common exposure and park (low exposure. The concentration at hot spots range from 3.2 to 5.4 µg/m3 for benzene, 38.0 to 80.3 µg/m3 for toluene and 29.7 to 66.7 µg/m3 for xylene.The low BTX were found at the city periphery (Tesco-Lotus billboard sampling stations, roof level and in Hat Yai Municipal Park but no absolute background concentration could be defined. The monitoring results showed that at higher level from the street surface, the level of BTX tended to decrease and the BTX pollution built up along a street canyon (Sanehanuson Road according to the wind direction. The highest BTX were found at the underground parking, 23.5 725.1 and 267.9 µg/m3 respectively where both WHO guideline for Benzene (16.3 µg/m3 and Toluene (260 µg/m3 were exceeded.

  4. pEPito: a significantly improved non-viral episomal expression vector for mammalian cells

    Ogris Manfred

    2010-03-01

    Full Text Available Abstract Background The episomal replication of the prototype vector pEPI-1 depends on a transcription unit starting from the constitutively expressed Cytomegalovirus immediate early promoter (CMV-IEP and directed into a 2000 bp long matrix attachment region sequence (MARS derived from the human β-interferon gene. The original pEPI-1 vector contains two mammalian transcription units and a total of 305 CpG islands, which are located predominantly within the vector elements necessary for bacterial propagation and known to be counterproductive for persistent long-term transgene expression. Results Here, we report the development of a novel vector pEPito, which is derived from the pEPI-1 plasmid replicon but has considerably improved efficacy both in vitro and in vivo. The pEPito vector is significantly reduced in size, contains only one transcription unit and 60% less CpG motives in comparison to pEPI-1. It exhibits major advantages compared to the original pEPI-1 plasmid, including higher transgene expression levels and increased colony-forming efficiencies in vitro, as well as more persistent transgene expression profiles in vivo. The performance of pEPito-based vectors was further improved by replacing the CMV-IEP with the human CMV enhancer/human elongation factor 1 alpha promoter (hCMV/EF1P element that is known to be less affected by epigenetic silencing events. Conclusions The novel vector pEPito can be considered suitable as an improved vector for biotechnological applications in vitro and for non-viral gene delivery in vivo.

  5. Remedial Action Plan for the codisposal and stabilization of the Monument Valley and Mexican Hat uranium mill tailings at Mexican Hat, Utah

    This document is a revision of the original Mexiacan Hat Remedial Action Plan (RAP) and RAP Modification submitted in July 1988 and January 1989, respectively, along with updated design documents. This RAP has been developed to serve a two-fold purpose. It presents the activities proposed by the Department of Energy (DOE) to accomplish long-term stabilization and control of the residual radioactive materials (RRM) from Monument Valley, Arizona, and Mexican Hat, Utah, at the Mexican Hat disposal site. It also serves to document the concurrence of both the Navajo Nation and the Nuclear Regulatory Commission (NRC) in the remedial action. This agreement, upon execution by DOE and the Navajo Nation and concurrence by the NRC, becomes Appendix B of the Cooperative Agreement. This document has been structured to provide a comprehensive understanding of the remedial action proposed for the Monument Valley and Mexican Hat sites. It includes specific design and construction requirements for the remedial action. Pertinent information and data are included with reference given to the supporting documents. Section 2.0 presents the EPA standards, including a discussion of their objectives. Section 3. 0 summarizes the present site characteristics and provides a definition of site-specific problems. Section 4.0 is the site design for the proposed action. Section 5.0 presents the water resources protection strategy. Section 6.0 summarizes the plan for ensuring health and safety protection for the surrounding community and the on- site workers. Section 7.0 lists the responsibilities of the project participants. Section 8.0 describes the features of the long-term surveillance and maintenance plan

  6. Isolation and characterization of purine regulatory mutants of Salmonella typhimurium with an episomal purE-lac fusion.

    Thomulka, K W; Gots, J S

    1982-01-01

    Expression of the purE operon of Salmonella typhimurium was analyzed by using an Escherichia coli F' episome containing a purE-lac fusion. The fusion removes the lacOP and part of the lacZ genes of the lac operon and places the intact lacY and lacA genes under control of the purE operon as shown by inhibition of growth on melibiose (lacY) and repression of thiogalactoside transacetylase (lacA) by various purines. Two classes of regulatory-deficient mutants were found among those resistant to ...

  7. Environmental Assessment of Remedial Action at the Mexican Hat Uranium Mill Tailings Site, Mexican Hat, Utah

    U.S. Department of Energy

    1987-01-01

    This document assesses the environmental impacts of the proposed remedial action at the Mexican Hat uranium mill tailings site located on the Navajo Reservation in southern Utah. The site covers 235 acres and contains 69 acres of tailings and several of the original mill structures. The Uranium Mill Tailings Radiation Control Act (UMTRCA) of 1978, Public Law 95-604 (PL95-604), authorized the U.S. Department of Energy to clean up the site to reduce the potential health impacts associated wit...

  8. Ground-based transit observations of the HAT-P-18, HAT-P-19, HAT-P-27/WASP-40 and WASP-21 systems

    Seeliger, M; Errmann, R; Richter, S; Ohlert, J M; Chen, W P; Guo, J K; Göğüş, E; Güver, T; Aydın, B; Mottola, S; Hellmich, S; Fernandez, M; Aceituno, F J; Dimitrov, D; Kjurkchieva, D; Jensen, E; Cohen, D; Kundra, E; Pribulla, T; Vaňko, M; Budaj, J; Mallonn, M; Wu, Z Y; Zhou, X; Raetz, St; Adam, C; Schmidt, T O B; Ide, A; Mugrauer, M; Marschall, L; Hackstein, M; Chini, R; Haas, M; Ak, T; Güzel, E; Özdönmez, A; Ginski, C; Marka, C; Schmidt, J G; Dincel, B; Werner, K; Dathe, A; Greif, J; Wolf, V; Buder, S; Pannicke, A; Puchalski, D; Neuhäuser, R

    2015-01-01

    As part of our ongoing effort to investigate transit timing variations (TTVs) of known exoplanets, we monitored transits of the four exoplanets HAT-P-18b, HAT-P-19b, HAT-P-27b/WASP-40b and WASP-21b. All of them are suspected to show TTVs due to the known properties of their host systems based on the respective discovery papers. During the past three years 46 transit observations were carried out, mostly using telescopes of the Young Exoplanet Transit Initiative. The analyses are used to refine the systems orbital parameters. In all cases we found no hints for significant TTVs, or changes in the system parameters inclination, fractional stellar radius and planet to star radius ratio. However, comparing our results with those available in the literature shows that we can confirm the already published values.

  9. A Sequence-Independent Strategy for Amplification and Characterisation of Episomal Badnavirus Sequences Reveals Three Previously Uncharacterised Yam Badnaviruses.

    Bömer, Moritz; Turaki, Aliyu A; Silva, Gonçalo; Kumar, P Lava; Seal, Susan E

    2016-01-01

    Yam (Dioscorea spp.) plants are potentially hosts to a diverse range of badnavirus species (genus Badnavirus, family Caulimoviridae), but their detection is complicated by the existence of integrated badnavirus sequences in some yam genomes. To date, only two badnavirus genomes have been characterised, namely, Dioscorea bacilliform AL virus (DBALV) and Dioscorea bacilliform SN virus (DBSNV). A further 10 tentative species in yam have been described based on their partial reverse transcriptase (RT)-ribonuclease H (RNaseH) sequences, generically referred to here as Dioscorea bacilliform viruses (DBVs). Further characterisation of DBV species is necessary to determine which represent episomal viruses and which are only present as integrated badnavirus sequences in some yam genomes. In this study, a sequence-independent multiply-primed rolling circle amplification (RCA) method was evaluated for selective amplification of episomal DBV genomes. This resulted in the identification and characterisation of nine complete genomic sequences (7.4-7.7 kbp) of existing and previously undescribed DBV phylogenetic groups from Dioscorea alata and Dioscorea rotundata accessions. These new yam badnavirus genomes expand our understanding of the diversity and genomic organisation of DBVs, and assist the development of improved diagnostic tools. Our findings also suggest that mixed badnavirus infections occur relatively often in West African yam germplasm. PMID:27399761

  10. Radiologic characterization of the Mexican Hat, Utah, uranium mill tailings remedial action site: Appendix D, Addenda D1--D7

    Ludlam, J.R.

    1985-01-01

    This radiologic characterization of the inactive uranium millsite at Mexican Hat, Utah, was conducted by Bendix Field Engineering Corporation foe the US Department of Energy (DOE), Grand Junction Project Office, in response to and in accord with a Statement of Work prepared by the DOE Uranium Mill tailings Remedial Action Project (UMTRAP) Technical Assistance Contractor, Jacobs Engineering Group, Inc. the objective of this project was to determine the horizontal and vertical extent of contamination that exceeds the US Environmental Protection Agency (EPA) standards at the Mexican Hat site. The data presented in this report are required for characterization of the areas adjacent to the Mexican Hat tailings piles and for the subsequent design of cleanup activities. Some on-pile sampling was required to determine the depth of the 15-pCi/g Ra-226 interface in an area where wind and water erosion has taken place.

  11. Kepler Photometry Of HAT-P-11: Starspots And Spin-orbit Misalignment

    Sanchis Ojeda, Roberto; Winn, J.

    2011-09-01

    I will present the analysis of 26 light curves of HAT-P-11 obtained with the Kepler satellite over 4 months. The light curves show spot-crossing anomalies, which are used to demonstrate that the stellar rotation and planetary orbit are misaligned by 90 +/- 23 degrees. This method of measuring spin-orbit alignment is purely photometric and is therefore complementary to the spectroscopic Rossiter-McLaughlin effect. Furthermore this new technique delivers the three-dimensional spin-orbit angle rather than the sky projection. For HAT-P-11 the analysis also shows that star spots occur at certain preferred latitudes on the star, as is the case for the Sun. We expect that these preferred latitudes will migrate toward the stellar equator over the years, in analogy with the "butterfly diagram" observed for sunspots. Thus, data from an extended Kepler mission will allow for a new and powerful probe of starspot activity cycles.

  12. Final audit report of remedial action construction at the UMTRA Project Mexican Hat, Utah -- Monument Valley, Arizona, sites

    The final audit report for remedial action at the Mexican Hat, Utah, Monument Valley, Arizona, Uranium Mill Tailings Remedial Action (UMTRA) Project sites consists of a summary of the radiological surveillances/audits, quality assurance (QA) in-process surveillances, and QA remedial action close-out inspections performed by the US Department of Energy (DOE) and the Technical Assistance Contractor (TAC); on-site construction reviews (OSCR) performed by the US Nuclear Regulatory Commission (NRC); and a surveillance performed by the Navajo Nation. This report refers to remedial action activities performed at the Mexican Hat, Utah--Monument Valley, Arizona, Uranium Mill Tailings Remedial Action (UMTRA) Project sites

  13. Environmental assessment of remedial action at the Mexican Hat uranium mill tailings site, Mexican Hat, Utah

    This document assesses the environmental impacts of the proposed remedial action at the Mexican Hat uranium mill tailings site located on the Navajo Reservation in southern Utah. The site covers 235 acres and contains 69 acres of tailings and several of the original mill structures. Remedial action must be performed in accordance with standards and with the concurrence of the US Nuclear Regulatory Commission and the Navajo Nation. The proposed action is to stabilize the tailings within the present tailings site by consolidating the tailings and associated contaminated soils into a recontoured pile. A radon barrier of compacted earth would be constructed over the pile, and various erosion control measures would be taken to assure the long-term stability of the pile. The no action alternative is also assessed in this document. 240 refs., 12 figs., 20 tabs

  14. HATS-7b: A Hot Super Neptune Transiting a Quiet K Dwarf Star

    Bakos, G Á; Bayliss, D; Hartman, J D; Zhou, G; Brahm, R; Mancini, L; deVal-Borro, M; Bhatti, W; Jordán, A; Rabus, M; Espinoza, N; Csubry, Z; Howard, A W; Fulton, B J; Buchhave, L A; Ciceri, S; Henning, T; Schmidt, B; Isaacson, H; Noyes, R W; Marcy, G W; Suc, V; Howe, A R; Burrows, A S; Lázár, J; Papp, I; Sári, P

    2015-01-01

    We report the discovery by the HATSouth network of HATS-7b, a transiting Super-Neptune with a mass of 0.120+/-0.012 M_Jup, a radius of 0.563+0.046-0.034 R_Jup, and an orbital period of 3.1853 days. The host star is a moderately bright (V = 13.340+/-0.010 mag, K_S = 10.976+/-0.026 mag) K dwarf star with a mass of 0.849+/-0.027 M_Sun, a radius of 0.815+0.049-0.035 R_Sun, and a metallicity of [Fe/H]= +0.250+/-0.080. The star is photometrically quiet to within the precision of the HATSouth measurements, has low RV jitter, and shows no evidence for chromospheric activity in its spectrum. HATS-7b is the second smallest radius planet discovered by a wide-field ground-based transit survey, and one of only a handful of Neptune-size planets with mass and radius determined to 10% precision. Theoretical modeling of HATS-7b yields a hydrogen-helium fraction of 18+/-4% (rock-iron core and H2-He envelope), or 9+/-4% (ice core and H2-He envelope), i.e.it has a composition broadly similar to that of Uranus and Neptune, and ve...

  15. Vector Boson Jets with BlackHat and Sherpa

    Berger, C.F.; /MIT, LNS; Bern, Z.; /UCLA; Dixon, Lance J.; /SLAC; Cordero, F.Febres; /Simon Bolivar U.; Forde, D.; /CERN /NIKHEF, Amsterdam; Gleisberg, T.; /SLAC; Ita, H.; /UCLA; Kosower, D.A.; /Saclay, SPhT; Maitre, D.; /Durham U.

    2010-08-25

    We review recent NLO QCD results for W, Z + 3-jet production at hadron colliders, computing using BlackHat and SHERPA, and including also some new results for Z + 3-jet production for the LHC at 7 TeV. We report new progress towards the NLO cross section for W + 4-jet production. In particular, we show that the virtual matrix elements produced by BlackHat are numerically stable. We also show that with an improved integrator and tree-level matrix elements from BlackHat, SHERPA produces well-behaved real-emission contributions. As an illustration, we present the real-emission contributions - including dipole-subtraction terms - to the p{sub T} distribution of the fourth jet, for a single subprocess with the maximum number of gluons.

  16. Vector Boson + Jets with BlackHat and SHERPA

    Berger, C F; Dixon, L J; Cordero Febres, F; Forde, D; Gleisberg, T; Ita, H; Kosower, D A; Maitre, D

    2010-01-01

    We review recent NLO QCD results for W,Z + 3-jet production at hadron colliders, computed using BlackHat and SHERPA. We also include some new results for Z + 3-jet production at the LHC at 7 TeV. We report new progress towards the NLO cross section for W + 4-jet production. In particular, we show that the virtual matrix elements produced by BlackHat are numerically stable. We also show that with an improved integrator and tree-level matrix elements from BlackHat, SHERPA produces well-behaved real-emission contributions. As an illustration, we present the real-emission contributions -- including dipole-subtraction terms -- to the p_T distribution of the fourth jet, for a single subprocess with the maximum number of gluons.

  17. Ectopic expression of AID in a non-B cell line triggers A:T and G:C point mutations in non-replicating episomal vectors.

    Tihana Jovanic

    Full Text Available Somatic hypermutation (SHM of immunoglobulin genes is currently viewed as a two step process initiated by the deamination of deoxycytidine (C to deoxyuridine (U, catalysed by the activation induced deaminase (AID. Phase 1 mutations arise from DNA replication across the uracil residue or the abasic site, generated by the uracil-DNA glycosylase, yielding transitions or transversions at G:C pairs. Phase 2 mutations result from the recognition of the U:G mismatch by the Msh2/Msh6 complex (MutS Homologue, followed by the excision of the mismatched nucleotide and the repair, by the low fidelity DNA polymerase eta, of the gap generated by the exonuclease I. These mutations are mainly focused at A:T pairs. Whereas in activated B cells both G:C and A:T pairs are equally targeted, ectopic expression of AID was shown to trigger only G:C mutations on a stably integrated reporter gene. Here we show that when using non-replicative episomal vectors containing a GFP gene, inactivated by the introduction of stop codons at various positions, a high level of EGFP positive cells was obtained after transient expression in Jurkat cells constitutively expressing AID. We show that mutations at G:C and A:T pairs are produced. EGFP positive cells are obtained in the absence of vector replication demonstrating that the mutations are dependent only on the mismatch repair (MMR pathway. This implies that the generation of phase 1 mutations is not a prerequisite for the expression of phase 2 mutations.

  18. HAT AVERAGE MULTIRESOLUTION WITH ERROR CONTROL IN 2-D

    Sergio Amat

    2004-01-01

    Multiresolution representations of data are a powerful tool in data compression. For a proper adaptation to the singularities, it is crucial to develop nonlinear methods which are not based on tensor product. The hat average framework permets develop adapted schemes for all types of singularities. In contrast with the wavelet framework these representations cannot be considered as a change of basis, and the stability theory requires different considerations. In this paper, non separable two-dimensional hat average multiresolution processing algorithms that ensure stability are introduced. Explicit error bounds are presented.

  19. The long duration flight of the TopHat experiment

    Silverberg, R. F.; Aguirre, J.; Bezaire, J.;

    2003-01-01

    The TopHat instrument was designed to operate on the top of a high altitude balloon. From this location, the experiment could efficiently observe using a clean beam with extremely low contamination from the far side lobes of the instrument beam. The experiment was designed to scan a large portion...... detectors operating at ~250mK. Here, we report on the flight of the TopHat experiment over Antarctica in January, 2001 and describe the scientific goals, the operation, and in-flight performance....

  20. Research outcome for enhancement production of pummelo Hom Hat Yai

    Wunnachit, W.

    2005-11-01

    Full Text Available Klong Utapao basin of Songkhla province. It has been grown for commercial purposes recently. This pummelo has prominent characteristics of vigorous tree, large fruit, thick rind, purple to red flesh and acidsweet taste, and is seedless. Because it is a new crop with small scale planting, there is limited plant basis information and few research reports compared to other main economical crops. Since the year 1994 there are 3 thesis research titles focusing on flowering and fruiting of this crop. They are 1 Floral biology and pollination of pummelo cv. Hom Hat Yai by Kaewtubtim (1994, 2 Effect of pollination on fruit setting, seediness and fruit qualities of pummelo cv. Hom Hat Yai by Karnjanapakorn (2000, 3 The influence of gibberellic acid (GA3 on fruit set and premature fruit development of pummelo cv. Hom Hat Yai by Dumnoi (2001. This paper reports and discusses those research outcomes for enhancement of production of pummelo cv. Hom Hat Yai in 3 aspects. 1 This pummelo sets fruit parthenocarpically. 2 This seedless pummelo sets seeds with cross pollination. 3 This pummelo sets more seedless fruits by GA3 application.

  1. Exoplanet Transits Registered at the Universidad de Monterrey Observatory. Part I: HAT-P-12b, HAT-P-13b, HAT-P-16b, HAT-P-23b and WASP-10b

    Sada, Pedro V

    2016-01-01

    Forty transits of the exoplanets HAT-P-12b, HAT-P-13b, HAT-P-16b, HAT-P-23b and WASP-10b were recorded with the 0.36m telescope at the Universidad de Monterrey Observatory. The images were captured with a standard Johnson-Cousins Rc and Ic and Sloan z' filters and processed to obtain individual light curves of the events. These light curves were successfully combined for each system to obtain a resulting one of higher quality, but with a slightly larger time sampling rate. A reduction by a factor of about four in per-point scatter was typically achieved, resulting in combined light curves with a scatter of ~1 mmag. The noise characteristics of the combined light curves were verified by comparing Allan variance plots of the residuals. The combined light curves for each system, along with radial velocity measurements from the literature when available, were modeled using a Monte Carlo method to obtain the essential parameters that characterize the systems. Our results for all these systems confirm the derived t...

  2. HAT-P-50b, HAT-P-51b, HAT-P-52b, and HAT-P-53b: Three Transiting Hot Jupiters and a Transiting Hot Saturn From the HATNet Survey

    Hartman, Joel D; Bakos, Gáspár Á; Bieryla, Allyson; Kovács, Géza; Latham, David W; Csubry, Zoltan; de Val-Borro, Miguel; Penev, Kaloyan; Buchhave, Lars A; Torres, Guillermo; Howard, Andrew W; Marcy, Geoff W; Johnson, John A; Isaacson, Howard; Sato, Bun'ei; Boisse, Isabelle; Falco, Emilio; Everett, Mark E; Szklenar, Tamas; Fulton, Benjamin J; Shporer, Avi; Kovács, Tamas; Hansen, Terese; Béky, Bence; Noyes, Robert W; Lázár, József; Papp, Istvan; Sári, Pál

    2015-01-01

    We report the discovery and characterization of four transiting exoplanets by the HATNet survey. The planet HAT-P-50b has a mass of 1.35 M_J and a radius of 1.29 R_J, and orbits a bright (V = 11.8 mag) M = 1.27 M_sun, R = 1.70 R_sun star every P = 3.1220 days. The planet HAT-P-51b has a mass of 0.31 M_J and a radius of 1.29 R_J, and orbits a V = 13.4 mag, M = 0.98 M_sun, R = 1.04 R_sun star with a period of P = 4.2180 days. The planet HAT-P-52b has a mass of 0.82 M_J and a radius of 1.01 R_J, and orbits a V = 14.1 mag, M = 0.89 M_sun, R = 0.89 R_sun star with a period of P = 2.7536 days. The planet HAT-P-53b has a mass of 1.48 M_J and a radius of 1.32 R_J, and orbits a V = 13.7 mag, M = 1.09 M_sun, R = 1.21 R_sun star with a period of P = 1.9616 days. All four planets are consistent with having circular orbits and have masses and radii measured to better than 10% precision. The low stellar jitter and favorable R_P/R_star ratio for HAT-P-51 make it a promising target for measuring the Rossiter-McLaughlin effec...

  3. Exoplanet Transits Registered at the Universidad de Monterrey Observatory. I. HAT-P-12b, HAT-P-13b, HAT-P-16b, HAT-P-23b, and WASP-10b

    Sada, Pedro V.; Ramón-Fox, Felipe G.

    2016-02-01

    Forty transits of the exoplanets HAT-P-12b, HAT-P-13b, HAT-P-16b, HAT-P-23b, and WASP-10b were recorded with the 0.36 m telescope at the Universidad de Monterrey Observatory. The images were captured with a standard Johnson-Cousins Rc and Ic and Sloan z’ filters and processed to obtain individual light curves of the events. These light curves were successfully combined for each system to obtain a resulting one of higher quality, but with a slightly larger time sampling rate. A reduction by a factor of about four in per-point scatter was typically achieved, resulting in combined light curves with a scatter of ∼1 mmag. The noise characteristics of the combined light curves were verified by comparing Allan variance plots of the residuals. The combined light curves for each system, along with radial velocity measurements from the literature when available, were modeled using a Monte Carlo method to obtain the essential parameters that characterize the systems. Our results for all these systems confirm the derived transit parameters (the planet-to-star radius ratio, {R}{{p}}/{R}*; the scaled semimajor axis, a/{R}*; the orbital inclination, i; in some cases the eccentricity, e; and argument of periastron of the orbit, ω), validating the methodology. This technique can be used by small college observatories equipped with modest-sized telescopes to help characterize known extrasolar planet systems. In some instances, the uncertainties of the essential transit parameters are also reduced. For HAT-P-23b, in particular, we derive a planet size 4.5 ± 1.0% smaller. We also derive improved linear periods for each system, useful for scheduling observations.

  4. Structural basis of hAT transposon end recognition by Hermes, an octameric DNA transposase from Musca domestica.

    Hickman, Alison B; Ewis, Hosam E; Li, Xianghong; Knapp, Joshua A; Laver, Thomas; Doss, Anna-Louise; Tolun, Gökhan; Steven, Alasdair C; Grishaev, Alexander; Bax, Ad; Atkinson, Peter W; Craig, Nancy L; Dyda, Fred

    2014-07-17

    Hermes is a member of the hAT transposon superfamily that has active representatives, including McClintock's archetypal Ac mobile genetic element, in many eukaryotic species. The crystal structure of the Hermes transposase-DNA complex reveals that Hermes forms an octameric ring organized as a tetramer of dimers. Although isolated dimers are active in vitro for all the chemical steps of transposition, only octamers are active in vivo. The octamer can provide not only multiple specific DNA-binding domains to recognize repeated subterminal sequences within the transposon ends, which are important for activity, but also multiple nonspecific DNA binding surfaces for target capture. The unusual assembly explains the basis of bipartite DNA recognition at hAT transposon ends, provides a rationale for transposon end asymmetry, and suggests how the avidity provided by multiple sites of interaction could allow a transposase to locate its transposon ends amidst a sea of chromosomal DNA. PMID:25036632

  5. Structural Basis for Transposon End Recognition by Hermes, an Octameric hAT DNA Transposase from Musca domestica

    Hickman, Alison B.; Ewis, Hosam E.; Li, Xianghong; Knapp, Joshua A.; Laver, Thomas; Doss, Anna-Louise; Tolun, Gökhan; Steven, Alasdair C.; Grishaev, Alexander; Bax, Ad; Atkinson, Peter W.; Craig, Nancy L.; Dyda, Fred

    2014-01-01

    SUMMARY Hermes is a member of the hAT transposon superfamily which has active representatives, including McClintock's archetypal Ac mobile genetic element, in many eukaryotic species. The crystal structure of the Hermes transposase-DNA complex reveals that Hermes forms an octameric ring organized as a tetramer of dimers. While isolated dimers are active in vitro for all the chemical steps of transposition, only octamers are active in vivo. The octamer can provide not only multiple specific DNA-binding domains to recognize repeated subterminal sequences within the transposon ends, which are important for activity, but also multiple non-specific DNA binding surfaces for target capture. The unusual assembly explains the basis of bipartite DNA recognition at hAT transposon ends, provides a rationale for transposon end asymmetry, and suggests how the avidity provided by multiple sites of interaction could allow a transposase to locate its transposon ends amidst a sea of chromosomal DNA. PMID:25036632

  6. Einstein's $R^{\\hat{0} \\hat{0}}$ equation for non-relativistic sources derived from Einstein's inertial motion and the Newtonian law for relative acceleration

    ,

    2016-01-01

    With Einstein's inertial motion (free-falling and non-rotating relative to gyroscopes), geodesics for non-relativistic particles can intersect repeatedly, allowing one to compute the space-time curvature $R^{\\hat{0} \\hat{0}}$ exactly. Einstein's $R^{\\hat{0} \\hat{0}}$ for strong gravitational fields and for relativistic source-matter is identical with the Newtonian expression for the relative radial acceleration of neighboring free-falling test-particles, spherically averaged.--- Einstein's field equations follow from Newtonian experiments, local Lorentz-covariance, and energy-momentum conservation combined with the Bianchi identity.

  7. Experimental studies on the axial crash behavior of aluminum foam-filled hat sections

    WANG Qing-chun; FAN Zi-jie; GUI Liang-jin; WANG Zheng-hong; FU Zi-lai

    2006-01-01

    Drop hammer tests were carried out to study the axial crash behavior of aluminum foam-filled hat sections.First,the axial crash tests of the empty hat sections,aluminum foam and the aluminum foam-filled hat sections were carried out;then,based upon the test results,the axial crash behavior of the aluminum foam-filled hat sections were analyzed.It was found that aluminum foam filling can increase the energy absorption capacities of the hat sections.Compared with the non-filled structures,aluminum foamfilled structures were much more stable and needed less mass to absorb the specified energy.

  8. Schrodinger's Hat: Electromagnetic, acoustic and quantum amplifiers via transformation optics

    Greenleaf, Allan; Lassas, Matti; Uhlmann, Gunther

    2011-01-01

    The advent of transformation optics and metamaterials has made possible devices producing extreme effects on wave propagation. Here we give theoretical designs for devices, Schr\\"odinger hats, acting as invisible concentrators of waves. These exist for any wave phenomenon modeled by either the Helmholtz or Schr\\"odinger equations, e.g., polarized waves in EM, pressure waves in acoustics and matter waves in QM, and occupy one part of a parameter space continuum of wave-manipulating structures which also contains standard transformation optics based cloaks, resonant cloaks and cloaked sensors. For EM and acoustic Schr\\"odinger hats, the resulting centralized wave is a localized excitation. In QM, the result is a new charged quasiparticle, a \\emph{quasmon}, which causes conditional probabilistic illusions. We discuss possible solid state implementations.

  9. A comparison of synthetic oligodeoxynucleotides, DNA fragments and AAV-1 for targeted episomal and chromosomal gene repair

    Leclerc Xavier

    2009-04-01

    Full Text Available Abstract Background Current strategies for gene therapy of inherited diseases consist in adding functional copies of the gene that is defective. An attractive alternative to these approaches would be to correct the endogenous mutated gene in the affected individual. This study presents a quantitative comparison of the repair efficiency using different forms of donor nucleic acids, including synthetic DNA oligonucleotides, double stranded DNA fragments with sizes ranging from 200 to 2200 bp and sequences carried by a recombinant adeno-associated virus (rAAV-1. Evaluation of each gene repair strategy was carried out using two different reporter systems, a mutated eGFP gene or a dual construct with a functional eGFP and an inactive luciferase gene, in several different cell systems. Gene targeting events were scored either following transient co-transfection of reporter plasmids and donor DNAs, or in a system where a reporter construct was stably integrated into the chromosome. Results In both episomal and chromosomal assays, DNA fragments were more efficient at gene repair than oligonucleotides or rAAV-1. Furthermore, the gene targeting frequency could be significantly increased by using DNA repair stimulating drugs such as doxorubicin and phleomycin. Conclusion Our results show that it is possible to obtain repair frequencies of 1% of the transfected cell population under optimized transfection protocols when cells were pretreated with phleomycin using rAAV-1 and dsDNA fragments.

  10. Schrodinger's Hat: Electromagnetic, acoustic and quantum amplifiers via transformation optics

    Greenleaf, Allan; Kurylev, Yaroslav; Lassas, Matti; Uhlmann, Gunther

    2011-01-01

    The advent of transformation optics and metamaterials has made possible devices producing extreme effects on wave propagation. Here we give theoretical designs for devices, Schr\\"odinger hats, acting as invisible concentrators of waves. These exist for any wave phenomenon modeled by either the Helmholtz or Schr\\"odinger equations, e.g., polarized waves in EM, pressure waves in acoustics and matter waves in QM, and occupy one part of a parameter space continuum of wave-manipulating structures ...

  11. The BlackHat Library for One-Loop Amplitudes

    Bern, Z; Cordero, F Febres; Hoeche, S; Ita, H; Kosower, D A; Maitre, D; Ozeren, K J

    2013-01-01

    We present recent next-to-leading order (NLO) results in perturbative QCD obtained using the BlackHat software library. We discuss the use of n-tuples to separate the lengthy matrix-element computations from the analysis process. The use of n-tuples allows many analyses to be carried out on the same phase-space samples, and also allows experimenters to conduct their own analyses using the original NLO computation.

  12. Numerical cubature from Archimedes' hat-box theorem

    Kuperberg, Greg

    2004-01-01

    Archimedes' hat-box theorem states that uniform measure on a sphere projects to uniform measure on an interval. This fact can be used to derive Simpson's rule. We present various constructions of, and lower bounds for, numerical cubature formulas using moment maps as a generalization of Archimedes' theorem. We realize some well-known cubature formulas on simplices as projections of spherical designs. We combine cubature formulas on simplices and tori to make new formulas on spheres. In partic...

  13. HAT-P-44b, HAT-P-45b, AND HAT-P-46b: Three transiting hot Jupiters in possible multi-planet systems

    We report the discovery by the HATNet survey of three new transiting extrasolar planets orbiting moderately bright (V = 13.2, 12.8, and 11.9) stars. The planets have orbital periods of 4.3012, 3.1290, and 4.4631 days, masses of 0.35, 0.89, and 0.49 M J, and radii of 1.24, 1.43, and 1.28 R J. The stellar hosts have masses of 0.94, 1.26, and 1.28 M ☉. Each system shows significant systematic variations in its residual radial velocities, indicating the possible presence of additional components. Based on its Bayesian evidence, the preferred model for HAT-P-44 consists of two planets, including the transiting component, with the outer planet having a period of 872 days, eccentricity of 0.494 ± 0.081, and a minimum mass of 4.0 M J. Due to aliasing we cannot rule out alternative solutions for the outer planet having a period of 220 days or 438 days. For HAT-P-45, at present there is not enough data to justify the additional free parameters included in a multi-planet model; in this case a single-planet solution is preferred, but the required jitter of 22.5 ± 6.3 m s–1 is relatively high for a star of this type. For HAT-P-46 the preferred solution includes a second planet having a period of 78 days and a minimum mass of 2.0 M J, however the preference for this model over a single-planet model is not very strong. While substantial uncertainties remain as to the presence and/or properties of the outer planetary companions in these systems, the inner transiting planets are well characterized with measured properties that are fairly robust against changes in the assumed models for the outer planets. Continued radial velocity monitoring is necessary to fully characterize these three planetary systems, the properties of which may have important implications for understanding the formation of hot Jupiters.

  14. Genetic reprogramming of human amniotic cells with episomal vectors: neural rosettes as sentinels in candidate selection for validation assays

    Patricia G. Wilson

    2014-11-01

    Full Text Available The promise of genetic reprogramming has prompted initiatives to develop banks of induced pluripotent stem cells (iPSCs from diverse sources. Sentinel assays for pluripotency could maximize available resources for generating iPSCs. Neural rosettes represent a primitive neural tissue that is unique to differentiating PSCs and commonly used to identify derivative neural/stem progenitors. Here, neural rosettes were used as a sentinel assay for pluripotency in selection of candidates to advance to validation assays. Candidate iPSCs were generated from independent populations of amniotic cells with episomal vectors. Phase imaging of living back up cultures showed neural rosettes in 2 of the 5 candidate populations. Rosettes were immunopositive for the Sox1, Sox2, Pax6 and Pax7 transcription factors that govern neural development in the earliest stage of development and for the Isl1/2 and Otx2 transcription factors that are expressed in the dorsal and ventral domains, respectively, of the neural tube in vivo. Dissociation of rosettes produced cultures of differentiation competent neural/stem progenitors that generated immature neurons that were immunopositive for βIII-tubulin and glia that were immunopositive for GFAP. Subsequent validation assays of selected candidates showed induced expression of endogenous pluripotency genes, epigenetic modification of chromatin and formation of teratomas in immunodeficient mice that contained derivatives of the 3 embryonic germ layers. Validated lines were vector-free and maintained a normal karyotype for more than 60 passages. The credibility of rosette assembly as a sentinel assay for PSCs is supported by coordinate loss of nuclear-localized pluripotency factors Oct4 and Nanog in neural rosettes that emerge spontaneously in cultures of self-renewing validated lines. Taken together, these findings demonstrate value in neural rosettes as sentinels for pluripotency and selection of promising candidates for advance

  15. Lightning as a possible source of the radio emission on HAT-P-11b

    Hodosán, G.; Rimmer, P. B.; Helling, Ch.

    2016-04-01

    Lightning induced radio emission has been observed on Solar System planets. There have been many attempts to observe exoplanets in the radio wavelength, however, no unequivocal detection has been reported. Lecavelier des Etangs et al. (2013, A&A, 552, A65) carried out radio transit observations of the exoplanet HAT-P-11b, and suggested that a small part of the radio flux can be attributed to the planet. In the current letter, we assume that this signal is real, and study if this radio emission could be caused by lightning in the atmosphere of the planet. We find that a lightning storm with 530 times larger flash densities than the Earth-storms with the largest lightning activity is needed to produce the observed signal from HAT-P-11b. The optical counterpart would nevertheless be undetectable with current technology. We show that HCN produced by lightning chemistry of such thunderstorms is observable 2-3 years after the storm, which produces signatures in the L (3.0μm - 4.0μm) and N (7.5μm - 14.5μm) infrared bands. We conclude that future, combined radio and infrared observations may lead to lightning detection on planets outside the Solar System.

  16. Lightning as a possible source of the radio emission on HAT-P-11b

    Hodosán, Gabriella; Helling, Christiane

    2016-01-01

    Lightning induced radio emission has been observed on Solar System planets. There have been many attempts to observe exoplanets in the radio wavelength, however, no unequivocal detection has been reported. Lecavelier des Etangs et al. (2013, A&A, 552, A65) carried out radio transit observations of the exoplanet HAT-P-11b, and suggested that a small part of the radio flux can be attributed to the planet. In the current letter, we assume that this signal is real, and study if this radio emission could be caused by lightning in the atmosphere of the planet. We find that a lightning storm with 530 times larger flash densities than the Earth-storms with the largest lightning activity is needed to produce the observed signal from HAT-P-11b. The optical counterpart would nevertheless be undetectable with current technology. We show that HCN produced by lightning chemistry of such thunderstorms is observable 2-3 years after the storm, which produces signatures in the L ($3.0 \\mu{\\rm m}-4.0 \\mu$m) and N ($7.5 \\mu{...

  17. Is lightning a possible source of the radio emission on HAT-P-11b?

    Hodosán, G.; Rimmer, P. B.; Helling, Ch.

    2016-09-01

    Lightning induced radio emission has been observed on Solar system planets. There have been many attempts to observe exoplanets in the radio wavelength, however, no unequivocal detection has been reported. Lecavelier des Etangs et al. carried out radio transit observations of the exoplanet HAT-P-11b, and suggested that a small part of the radio flux can be attributed to the planet. Here, we assume that this signal is real, and study if this radio emission could be caused by lightning with similar energetic properties like in the Solar system. We find that a lightning storm with 3.8 × 106 times larger flash densities than the Earth-storms with the largest lightning activity is needed to produce the observed signal from HAT-P-11b. The optical emission of such thunderstorm would be comparable to that of the host star. We show that HCN produced by lightning chemistry is observable 2-3 yr after the storm, which produces signatures in the L (3.0-4.0 μm) and N (7.5-14.5 μm) infrared bands. We conclude that it is unlikely that the observed radio signal was produced by lightning, however, future, combined radio and infrared observations may lead to lightning detection on planets outside the Solar system.

  18. Orta hat asimetrileri ve tedavi seçenekleri

    Serpil Çokakoğlu

    2012-01-01

    Full Text Available

    Nowadays the importance given to facial aesthetic is increasing. The coincidence of facial, maxiller and mandibuler dental midlines is very important requiring facial aesthetic. Midline asymmetries can be seen in form of  dental, skeletal and/or soft tissue asymmetries. In most of cases midline asymmetries accompany with facial asymmetries. Even if the amount of patients with midline asymmetry is not known to be aware of their problems, dental midline deviations observing without facial deformity can be noticed by most of patients with the help of their orthodontists. Symmetry of the dental and facial midlines comes at the beginning of the factors affecting treatment planning. For this reason midlines and due to the multifactorial etiology of asymmetries all of the factors that cause asymmetry must be evaluated properly during treatment planning.

    In this present article, our aim is try to give answers following questions: “Which factors cause midline asymmetries?’’, “Which type of asymmetries can be seen commonly in clinical?’’, “Do the using mechanics affect occlusion?’’,“Is it necessary to correct each type of midline asymmetries?’’, “Is there any mean threshold for esthetically acceptable midline asymmetries?

    Keywords: Midline, asymmetry.

     

    ÖZET

    Günümüzde yüz estetiğine verilen önem giderek artmaktadır. Fasiyal, maksiller ve mandibular dental orta hatların uyumu yüz estetiğinin sağlanması açısından oldukça önemlidir. Orta hat asimetrileri dental, iskeletsel ve/veya yumuşak dokuyu ilgilendiren şekilde görülebilir. Birçok olguda fasiyal asimetri şeklinde karşımıza çıkar. Asimetrili hastaların probleminin farkında olup olmadığı bilinmese de, fasiyal deformitenin gözlenmediği dental orta hat sapmaları çoğu hasta tarafından ancak ortodontistin yönlendirmesiyle fark edilebilir. Dental ve

  19. Ökosteuer hat zu geringerer Umweltbelastung des Verkehrs beigetragen

    Viktor Steiner; Johanna Cludius

    2010-01-01

    Allein durch die ökologische Steuerreform sind die Preise für Benzin und Diesel zwischen 1998 und 2003 in Deutschland in mehreren Schritten um über 20 Prozent gestiegen. Der Großteil des aus der Erhöhung der Energiesteuersätze resultierenden Aufkommens wurde zur Stabilisierung der Rentenversicherungsbeiträge verwendet. Hat die Ökosteuer neben diesem fiskalischen Ziel auch einen Beitrag zur nachhaltigen Reduktion des Verkehrsaufkommens der privaten Haushalte in Deutschland, somit zur Verringer...

  20. Topological B-model and ${\\hat c}=1$ String Theory

    Hyun, S; Park, J D; Yi, S H; Hyun, Seungjoon; Oh, Kyungho; Park, Jong-Dae; Yi, Sang-Heon

    2005-01-01

    We study the topological B-model on a deformed $\\Z_2$ orbifolded conifold by investigating variation of complex structures via quantum Kodaira-Spencer theories. The fermionic/brane formulation together with systematic utilization of symmetries of the geometry gives rise to a free fermion realization of the amplitudes. We derive Ward identities which solve the perturbed free energy exactly. We also obtain the corresponding Kontsevich-like matrix model. All these confirm the recent conjecture on the connection of the theory with ${\\hat c}=1$ type 0A string theory compactified at the radius $R=\\sqrt{\\alpha'/2}$.

  1. Bethe vectors of quantum integrable models based on Uq( gl-hat N)

    We study quantum Uq( gl-hat N) integrable models solvable by the nested algebraic Bethe ansatz. Different formulas are given for the right and left universal off-shell nested Bethe vectors. It is shown that these formulas can be related by certain morphisms of the positive Borel subalgebra in Uq( gl-hat N) into analogous subalgebra in Uq−1( gl-hat N). (paper)

  2. General survey of hAT transposon superfamily with highlight on hobo element in Drosophila.

    Ladevèze, Véronique; Chaminade, Nicole; Lemeunier, Françoise; Periquet, Georges; Aulard, Sylvie

    2012-09-01

    The hAT transposons, very abundant in all kingdoms, have a common evolutionary origin probably predating the plant-fungi-animal divergence. In this paper we present their general characteristics. Members of this superfamily belong to Class II transposable elements. hAT elements share transposase, short terminal inverted repeats and eight base-pairs duplication of genomic target. We focus on hAT elements in Drosophila, especially hobo. Its distribution, dynamics and impact on genome restructuring in laboratory strains as well as in natural populations are reported. Finally, the evolutionary history of hAT elements, their domestication and use as transgenic tools are discussed. PMID:23111927

  3. BLM realization for ${\\mathcal U}_{\\mathbb Z}(\\hat{\\frak{gl}}_n)$

    Fu, Qiang

    2012-01-01

    In 1990, Beilinson-Lusztig-MacPherson (BLM) discovered a realization \\cite[5.7]{BLM} for quantum $\\frak{gl}_n$ via a geometric setting of quantum Schur algebras. We will generailze their result to the classical affine case. More precisely, we first use Ringel-Hall algebras to construct an integral form ${\\mathcal U}_{\\mathbb Z}(\\hat{\\frak{gl}}_n)$ of ${\\mathcal U}(\\hat{\\frak{gl}}_n)$, where ${\\mathcal U}(\\hat{\\frak{gl}}_n)$ is the universal enveloping algebra of the loop algebra $\\hat{\\frak{g...

  4. HATS-7b: A Hot Super Neptune Transiting a Quiet K Dwarf Star

    Bakos, G. Á.; Penev, K.; Bayliss, D.; Hartman, J. D.; Zhou, G.; Brahm, R.; Mancini, L.; de Val-Borro, M.; Bhatti, W.; Jordán, A.; Rabus, M.; Espinoza, N.; Csubry, Z.; Howard, A. W.; Fulton, B. J.; Buchhave, L. A.; Ciceri, S.; Henning, T.; Schmidt, B.; Isaacson, H.; Noyes, R. W.; Marcy, G. W.; Suc, V.; Howe, A. R.; Burrows, A. S.; Lázár, J.; Papp, I.; Sári, P.

    2015-11-01

    We report the discovery by the HATSouth network of HATS-7b, a transiting Super-Neptune with a mass of 0.120 ± 0.012 {M}{{J}}, a radius of {0.563}-0.034+0.046 {R}{{J}}, and an orbital period of 3.1853 days. The host star is a moderately bright (V=13.340\\+/- 0.010 mag, {K}S=10.976\\+/- 0.026 mag) K dwarf star with a mass of 0.849 ± 0.027 {M}⊙ , a radius of {0.815}-0.035+0.049 {R}⊙ , and a metallicity of [{Fe}/{{H}}] =+0.250\\+/- 0.080. The star is photometrically quiet to within the precision of the HATSouth measurements, has low RV jitter, and shows no evidence for chromospheric activity in its spectrum. HATS-7b is the second smallest radius planet discovered by a wide-field ground-based transit survey, and one of only a handful of Neptune-size planets with mass and radius determined to 10% precision. Theoretical modeling of HATS-7b yields a hydrogen-helium fraction of 18 ± 4% (rock-iron core and H2-He envelope), or 9 ± 4% (ice core and H2-He envelope), i.e., it has a composition broadly similar to that of Uranus and Neptune, and very different from that of Saturn, which has 75% of its mass in H2-He. Based on a sample of transiting exoplanets with accurately (<20%) determined parameters, we establish approximate power-law relations for the envelopes of the mass-density distribution of exoplanets. HATS-7b, which, together with the recently discovered HATS-8b, is one of the first two transiting super-Neptunes discovered in the Southern sky, is a prime target for additional follow-up observations with Southern hemisphere facilities to characterize the atmospheres of Super-Neptunes (which we define as objects with mass greater than that of Neptune, and smaller than halfway between that of Neptune and Saturn, i.e., 0.054 {M}{{J}}\\lt {M}{{p}}\\lt 0.18 {M}{{J}}). The HATSouth network is operated by a collaboration consisting of Princeton University (PU), the Max Planck Institute für Astronomie (MPIA), the Australian National University (ANU), and the Pontificia

  5. HST hot Jupiter Transmission Spectral Survey: A detection of Na and strong optical absorption in HAT-P-1b

    Nikolov, N; Pont, F; Burrows, A S; Fortney, J J; Ballester, G E; Evans, T M; Huitson, C M; Wakeford, H R; Wilson, P A; Aigrain, S; Deming, D; Gibson, N P; Henry, G W; Knutson, H; Etangs, A Lecavelier des; Showman, A P; Vidal-Madjar, A; Zahnle, K

    2013-01-01

    We present an optical to near-infrared transmission spectrum of the hot Jupiter HAT-P-1b, based on HST observations, covering the spectral regime from 0.29 to 1.027{\\mu}m with STIS, which is coupled with a recent WFC3 transit (1.087 to 1.687{\\mu}m). We derive refined physical parameters of the HAT-P-1 system, including an improved orbital ephemeris. The transmission spectrum shows a strong absorption signature shortward of 0.55{\\mu}m, with a strong blueward slope into the near-ultraviolet. We detect atmospheric sodium absorption at a 3.3{\\sigma} significance level, but find no evidence for the potassium feature. The red data implies a marginally flat spectrum with a tentative absorption enhancement at wavelength longer than ~0.85{\\mu}m. The STIS and WFC3 spectra differ significantly in absolute radius level (4.3 +/- 1.6 pressure scale heights), implying strong optical absorption in the atmosphere of HAT-P-1b. The optical to near-infrared difference cannot be explained by stellar activity, as simulta- neous st...

  6. Enhanced Generation of Integration-free iPSCs from Human Adult Peripheral Blood Mononuclear Cells with an Optimal Combination of Episomal Vectors

    Wei Wen

    2016-06-01

    Full Text Available We previously reported the generation of integration-free induced pluripotent stem cells from adult peripheral blood (PB with an improved episomal vector (EV system, which uses the spleen focus-forming virus U3 promoter and an extra factor BCL-XL (B. Here we show an ∼100-fold increase in efficiency by optimizing the vector combination. The two most critical factors are: (1 equimolar expression of OCT4 (O and SOX2 (S, by using a 2A linker; (2 a higher and gradual increase in the MYC (M to KLF4 (K ratio during the course of reprogramming, by using two individual vectors to express M and K instead of one. The combination of EV plasmids (OS + M + K + B is comparable with Sendai virus in reprogramming efficiency but at a fraction of the cost. The generated iPSCs are indistinguishable from those from our previous approach in pluripotency and phenotype. This improvement lays the foundation for broad applications of episomal vectors in PB reprogramming.

  7. Heroin-assisted treatment (HAT) a decade later : A brief update on science and politics

    Fischer, Benedikt; Oviedo-Joekes, Eugenia; Blanken, Peter; Haasen, Christian; Rehm, Juergen; Schechter, Martin T.; Strang, John; van den Brink, Wim

    2007-01-01

    Since the initial Swiss heroin-assisted treatment (HAT) study conducted in the mid-1990s, several other jurisdictions in Europe and North America have implemented HAT trials. All of these studies embrace the same goal-investigating the utility of medical heroin prescribing for problematic opioid use

  8. Giant Paperclip Necklaces, Soup-Can Rings and Cherry-Pie Hats

    Winters, Laurel A.

    2011-01-01

    In this article, the author describes an art project inspired by the wearable sculpture art created by artist Marjorie Schick. Students used wallpaper paste and newspapers to create papier-mache for a mountain hat, a cherry-pie mask/hat, a "dress" shoe and a Cubistic mask. Cardboard was used in many of these things, in addition to being used as…

  9. Home Automated Telemanagement (HAT System to Facilitate Self-Care of Patients with Chronic Diseases

    Joseph Finkelstein

    2003-06-01

    Full Text Available Successful patient self-management requires a multidisciplinary approach that includes regular patient assessment, disease-specific education, control of medication adherence, implementation of health behavior change models and social support. Existing systems for computer-assisted disease management do not provide this multidisciplinary patient support and do not address treatment compliance issues. We developed the Home Automated Telemanagement (HAT system for patients with different chronic health conditions to facilitate their self-care. The HAT system consists of a home unit, HAT server, and clinician units. Patients at home use a palmtop or a laptop connected with a disease monitor on a regular basis. Each HAT session consists of self-testing, feedback, and educational components. The self-reported symptom data and objective results obtained from disease-specific sensors are automatically sent from patient homes to the HAT server in the hospital. Any web-enabled device can serve as a clinician unit to review patient results. The HAT system monitors self-testing results and patient compliance. The HAT system has been implemented and tested in patients receiving anticoagulation therapy, patients with asthma, COPD and other health conditions. Evaluation results indicated high level of acceptance of the HAT system by the patients and that the system has a positive impact on main clinical outcomes and patient satisfaction with medical care.

  10. Welche Bedeutung hat die Nachsorge nach bariatrischer Chirurgie?

    Bender G

    2010-01-01

    Full Text Available In der Mehrzahl der adipösen Patienten, insbesondere bei morbider Adipositas mit einem Body-Mass-Index (BMI 40, ist ein konservativer Versuch der dauerhaften Gewichtsreduktion frustran. Hier hat sich die bariatrische Chirurgie als eine sehr wirksame Therapie für eine erhebliche und auch anhaltende Gewichtsreduktion erwiesen. Auch die metabolischen Komorbiditäten (arterielle Hypertonie, Dyslipidämie, Diabetes mellitus Typ 2 bzw. gestörte Glukosetoleranz zeigen eine rasche postoperative Verbesserung. Hier muss insbesondere der insulinpflichtige Patient engmaschig nachbetreut werden. Abhängig von der Art des Eingriffs (restriktive, malabsorptive oder kombinierte Verfahren treten postoperativ unterschiedlich häufig und variabel ausgeprägt Nährstoffdefizite auf, die frühzeitig erkannt und adäquat behandelt werden müssen. Eine generelle Multivitamingabe ist hierbei essenziell.

  11. The man who mistook his wife for a hat

    Sacks, Oliver

    2011-01-01

    Oliver Sacks’s The Man Who Mistook His Wife for a Hat tells the stories of individuals afflicted with fantastic perceptual and intellectual aberrations: patients who have lost their memories and with them the greater part of their pasts; who are no longer able to recognize people and common objects; who are stricken with violent tics and grimaces or who shout involuntary obscenities; whose limbs have become alien; who have been dismissed as retarded yet are gifted with uncanny artistic or mathematical talents. If inconceivably strange, these brilliant tales remain, in Dr. Sacks’s splendid and sympathetic telling, deeply human. They are studies of life struggling against incredible adversity, and they enable us to enter the world of the neurologically impaired, to imagine with our hearts what it must be to live and feel as they do. A great healer, Sacks never loses sight of medicine’s ultimate responsibility: “the suffering, afflicted, fighting human subject.”

  12. The Effect Of Using The Creative Drama Method and The Six Thinking Hat Technique On Student Success and Attidudes In Eighth-Grade Revolution History and Kemalism Lesson

    Ali ALTIKULAÇ; Akhan, Nadire Emel

    2010-01-01

    In this research, it was aimed to compose the activities about how creative drama teaching method and six thinking hats teaching technique can be used in “Lausanne Peace Treaty” subject in Turkish Republic Revolution History and Kemalism lesson; describe and research whether the composed activities increase the students’ learning levels or not. For this aim, the Lausanne Peace Treaty-related activities were applied on an experiment group and traditional teaching techniques were applied on a c...

  13. Irradiation with heavy-ion particles changes the cellular distribution of human histone acetyltranferase HAT1

    Lebel, E.A.; Tafrov, S.; Boukamp, P.

    2010-06-01

    Hat1 was the first histone acetyltransferase identified, however its biological function is still unclear. In this report, we show that the human Hat1 has two isoforms. Isoform a has 418 amino acids (aa) and is localized exclusively in the nuclear matrix of normal human keratinocytes (NHKs). Isoform b has 334 aa and is located in thecytoplasm, the nucleoplasm, attached to the chromatin and to the nuclear matrix. Immunohistochemical analyses revealed that the bulk of Hat1 is confined to the nucleus, with much lesser amounts in the cytoplasm. Cells undergoing mitotic division have an elevated amount of Hat1 compared to non-mitotic ones. NHKs exposed to hydrogen peroxide (H2O2) or to a beam of high mass and energy (HZE) ion particles expressed bright nuclear staining for Hat1, a phenotype that was not observed in NHKs exposed to &947;-rays. We established that the enhanced nuclear staining for Hat1 in response to these treatments is regulated by the PI3K and the MAPK signaling pathways. Our observations clearly implicate Hat1 in the cellular response assuring the survival of the treated cells.

  14. An old HAT in human p300/CBP and yeast Rtt109.

    Bazan, J Fernando

    2008-06-15

    The crystal structure of the human p300 histone acetyltransferase (HAT) domain reveals a familiar alpha + beta fold with unique structural elaborations that merit its classification as a third divergent HAT branch alongside the GCN5-related N-acetyltransferase (GNAT) and MYST (MOZ, Ybf2/Sas3, Sas2, Tip60) families. Two key departures from the core GNAT/MYST HAT fold--a long unstructured chain (or "flap") overlaying the acetyl-CoA (AcCoA) binding groove, and a four-alpha-helix "tower" excursion from the main beta-sheet--critically contribute to the recognition and presumptive catalytic machinery of p300/CBP HAT enzymes. Kinetic and mutant analysis of this enlarged residue constellation in p300 (which is distinct from functional fingerprints drawn from GNAT or MYST complexes) led Liu et al., to suggest that p300/CBP works with an unorthodox "hit and run" mechanism that enlists Tyr1467 as the critical catalytic residue. In order to extend the evolutionary testbed for this variant HAT mechanism beyond the thin roll of p300/CBP orthologs, I propose that Rtt109, a novel yeast HAT that has so far eluded classification, is the prototype of a fungal clan of p300-related enzymes that preserve the embellished HAT fold, but further diversify its catalytic options. PMID:18583929

  15. HATS-11b and HATS-12b: Two transiting Hot Jupiters orbiting sub-solar metallicity stars selected for the K2 Campaign 7

    Rabus, M; Hartman, J D; Bakos, G Á; Espinoza, N; Brahm, R; Penev, K; Ciceri, S; Zhou, G; Bayliss, D; Mancini, L; Bhatti, W; de Val-Borro, M; Csbury, Z; Sato, B; Tan, T -G; Henning, T; Schmidt, B; Bento, J; Suc, V; Noyes, R; Lázár, J; Papp, I; Sári, P

    2016-01-01

    We report the discovery of two transiting extrasolar planets from the HATSouth survey. HATS-11, a V=14.1 G0-star shows a periodic 12.9 mmag dip in its light curve every 3.6192 days and a radial velocity variation consistent with a Keplerian orbit. HATS-11 has a mass of 1.000 $\\pm$ 0.060 M$_{\\odot}$, a radius of 1.444 $\\pm$ 0.057 M$_{\\odot}$ and an effective temperature of 6060 $\\pm$ 150 K, while its companion is a 0.85 $\\pm$ 0.12 M$_J$, 1.510 $\\pm$ 0.078 R$_J$ planet in a circular orbit. HATS-12 shows a periodic 5.1 mmag flux decrease every 3.1428 days and Keplerian RV variations around a V=12.8 F-star. HATS-12 has a mass of 1.489 $\\pm$ 0.071 M$_{\\odot}$, a radius of 2.21 $\\pm$ 0.21 R$_{\\odot}$, and an effective temperature of 6408 $\\pm$ 75 K. For HATS-12, our measurements indicate that this is a 2.38 $\\pm$ 0.11 M$_J$, 1.35 $\\pm$ 0.17 R$_J$ planet in a circular orbit. Both host stars show sub-solar metallicity of -0.390 $\\pm$ 0.060 dex and -0.100 $\\pm$ 0.040 dex, respectively and are (slightly) evolved stars....

  16. Lattice measurement of the couplings $\\hat g_\\infty$ and $g_{B^\\ast B \\pi}$

    Abada, A; Boucaud, P; Herdoiza, G; Leroy, J P; Le Yaouanc, A; Pène, O; Boucaud, Ph.

    2004-01-01

    We present the results of a quenched lattice QCD study of the coupling $\\hat g$, in the static heavy quark limit. After combining this with our previous results obtained by using propagating heavy quarks with a mass around the physical charm quark, we are able to interpolate to the $b$-quark sector. Our results are $\\hat g_\\infty = 0.48 \\pm 0.03\\pm 0.11$, $\\hat g_b = 0.58 \\pm 0.06 \\pm 0.10$, and $\\g_{B^\\ast B \\pi} = 47 \\pm 5 \\pm 8$.

  17. The Effect Of Using The Creative Drama Method and The Six Thinking Hat Technique On Student Success and Attidudes In Eighth-Grade Revolution History and Kemalism Lesson

    Ali ALTIKULAÇ

    2010-12-01

    Full Text Available In this research, it was aimed to compose the activities about how creative drama teaching method and six thinking hats teaching technique can be used in “Lausanne Peace Treaty” subject in Turkish Republic Revolution History and Kemalism lesson; describe and research whether the composed activities increase the students’ learning levels or not. For this aim, the Lausanne Peace Treaty-related activities were applied on an experiment group and traditional teaching techniques were applied on a checking group. In this study, which is an experimental and descriptive, it was attempted to show the use of creative drama teaching method and six thinking hats teaching technique in Turkish Republic Revolution History and Kemalism lesson and an answer was searched for the question “Is there any meaningful difference between the learning level and attitudes of experiment group and checking group?”

  18. Parameters of Recent Transits of HAT-P-23b

    Ramón-Fox, Felipe G

    2012-01-01

    Four transits of the exoplanet HAT-P-23b were recently observed with the 0.36m telescope at the Universidad de Monterrey Observatory. The four light curves were successfully combined to obtain a resulting one with reduced scattering per bin. This one was modeled using a Monte Carlo method to obtain the essential parameters that characterize the system. Assuming orbital parameters such as eccentricity, e, and longitude of periastron, w, from the discovery paper, we found values of Rp/R* = 0.1105 +0.0015-0.0013 for the planet-to-star radius ratio, a/R* = 4.23 +0.06-0.12 for the scaled semimajor axis, and an orbital inclination of the system of i = 87.9d +1.5-2.2. We also derive an improved orbital period of 1.2128868 +- 0.0000004 days (To = 2,454,852.26542 +- 0.00018 BJD_TDB) for the system.

  19. PARAMETERS OF RECENT TRANSITS OF HAT-P-23b

    F. G. Ramón-Fox

    2013-01-01

    Full Text Available Cuatro tránsitos del planeta extrasolar HAT-P-23b fueron observados recientemente con el telescopio de 0.36 m del Observatorio de la Universidad de Monterrey. Las cuatro curvas de luz fueron exitosamente combinadas para obtener una resultante de mayor calidad. Esta curva fue modelada utilizando un método de Monte Carlo para obtener los parámetros esenciales que caracterizan al sistema. Asumiendo parámetros orbitales como la excentricidad e y la longitud del periastro ! reportados en el artículo del descubrimiento, encontramos valores de Rp/R* = 0.1105+0.0015 −0.0013 para la razón del radio del planeta al radio estelar, a/R? = 4.23+0.06 −0.12 para el semieje mayor normalizado, y una inclinación orbital de i = 87.9?+1.5 −2.2. Obtenemos un período orbital de 1.2128868 ± 0.0000004 días (To = 2, 454, 852.26542 ± 0.00018 BJD TDB.

  20. Histone acetyltransferase HAT4 modulates navigation across G2/M and re-entry into G1 in Leishmania donovani.

    Yadav, Aarti; Chandra, Udita; Saha, Swati

    2016-01-01

    Histone acetyltransferases impact multiple processes. This study investigates the role of histone acetyltransferase HAT4 in Leishmania donovani. Though HAT4 was dispensable for survival, its elimination decreased cell viability and caused cell cycle defects, with HAT4-nulls experiencing an unusually long G2/M. Survival of HAT4-nulls in macrophages was also substantially compromised. DNA microarray analysis revealed that HAT4 modestly regulated the expression of only a select number of genes, thus not being a major modulator of global gene expression. Significantly, cdc20 was among the downregulated genes. To ascertain if decreased expression of cdc20 was responsible for HAT4-null growth and cell cycle defects we expressed LdCdc20 ectopically in HAT4-nulls. We found this to alleviate the aberrant growth and cell cycle progression patterns displayed by HAT4-nulls, with cells navigating G2/M phase and re-entering G1 phase smoothly. HAT4-nulls expressing LdCdc20 ectopically showed survival rates comparable to wild type within macrophages, suggesting that G2/M defects were responsible for poor survival of HAT4-nulls within host cells also. These are the first data analyzing the in vivo functional role of HAT4 in any trypanosomatid. Our results directly demonstrate for the first time a role for Cdc20 in regulating trypanosomatid G2/M events, opening avenues for further research in this area. PMID:27272906

  1. Application of Human-Autonomy Teaming (HAT) Patterns to Reduce Crew Operations (RCO)

    Shively, R. Jay; Brandt, Summer L.; Lachter, Joel; Matessa, Mike; Sadler, Garrett; Battiste, Henri

    2016-01-01

    Unmanned aerial systems, robotics, advanced cockpits, and air traffic management are all examples of domains that are seeing dramatic increases in automation. While automation may take on some tasks previously performed by humans, humans will still be required, for the foreseeable future, to remain in the system. The collaboration with humans and these increasingly autonomous systems will begin to resemble cooperation between teammates, rather than simple task allocation. It is critical to understand this human-autonomy teaming (HAT) to optimize these systems in the future. One methodology to understand HAT is by identifying recurring patterns of HAT that have similar characteristics and solutions. This paper applies a methodology for identifying HAT patterns to an advanced cockpit project.

  2. No isomorphism between the affine $\\hat sl(2)$ algebra and the N=2 superconformal algebras

    Gato-Rivera, Beatriz

    2008-01-01

    Since 1999 it became obvious that the would be `isomorphism' between the affine $\\hat sl(2)$ algebra and the N=2 superconformal algebras, proposed by some authors, simply does not work. However, this issue was never properly discussed in the literature and, as a result, some confusion still remains. In this article we finally settle down, clearly and unambiguously, the true facts: there is no isomorphism between the affine $\\hat sl(2)$ algebra and the N=2 superconformal algebras.

  3. Phase II, Title I engineering assessment of inactive uranium mill tailings, Mexican Hat site, Mexican Hat, Utah

    An engineering assessment of the problems resulting from the existence of radioactive uranium mill tailings at the Mexican Hat millsite in Utah is presented. Topographic maps, data on core drillings and radiometric measurements sufficient to determine areas and volumes of tailings and other radium-contaminated materials, the evaluation of resulting radiation exposures of individuals residing nearby, the investigation of site hydrology and meteorology, and the evaluation and costing of alternative corrective actions are presented. Radon gas release from the 2,200,000 tons of tailings on the site constitutes the most significant environmental impact. T he six alternative actions presented are directed towards restricting access to the site, returning the windblown tailings to the piles and stabilizing the piles with cover material, and consolidating the two piles into one pile and stabilizing it with cover material. Fencing around the site or the tailings and the decontamination of mill buildings is included in all options. Costs of the options range from $370,000 to $4,390,000

  4. HATS-17b: A Transiting Compact Warm Jupiter in a 16.3 Days Circular Orbit

    Brahm, R; Bakos, G Á; Penev, K; Espinoza, N; Rabus, M; Hartman, J D; Bayliss, D; Ciceri, S; Zhou, G; Mancini, L; Tan, T G; de Val-Borro, M; Bhatti, W; Csubry, Z; Bento, J; Henning, T; Schmidt, B; Suc, V; Lázár, J; Papp, I; Sári, P

    2015-01-01

    We report the discovery of HATS-17b, the first transiting warm Jupiter of the HATSouth network. HATS-17b transits its bright (V=12.4) G-type (M$_{\\star}$=1.131 $\\pm$ 0.030 M$_{\\odot}$, R$_{\\star}$=1.091$^{+0.070}_{-0.046}$ R$_{\\star}$) metal-rich ([Fe/H]=+0.3 dex) host star in a circular orbit with a period of P=16.2546 days. HATS-17b has a very compact radius of 0.777 $\\pm$ 0.056 R$_J$ given its Jupiter-like mass of 1.338 $\\pm$ 0.065 M$_J$. Up to 50% of the mass of HATS-17b may be composed of heavy elements in order to explain its high density with current models of planetary structure. HATS-17b is the longest period transiting planet discovered to date by a ground-based photometric survey, and is one of the brightest transiting warm Jupiter systems known. The brightness of HATS-17b will allow detailed follow-up observations to characterize the orbital geometry of the system and the atmosphere of the planet.

  5. Remedial Action Plan for the codisposal and stabilization of the Monument Valley and Mexican Hat uranium mill tailings at Mexican Hat, Utah: Appendices C--E. Final report

    NONE

    1993-02-01

    This document provides appendices C, D, and E this Remedial Action Plan (RAP) which is a revision of the original Mexican Hat Remedial Action Plan and RAP Modification submitted in July 1988 and January 1989, respectively, along with updated design documents. Appendix C provide the Radiological Support Plan, Appendix D provides the Site Characterization, and Appendix E provides the Water Resources Protection Strategy.

  6. Remedial Action Plan for the codisposal and stabilization of the Monument Valley and Mexican Hat uranium mill tailings at Mexican Hat, Utah: Appendices C--E. Final report

    This document provides appendices C, D, and E this Remedial Action Plan (RAP) which is a revision of the original Mexican Hat Remedial Action Plan and RAP Modification submitted in July 1988 and January 1989, respectively, along with updated design documents. Appendix C provide the Radiological Support Plan, Appendix D provides the Site Characterization, and Appendix E provides the Water Resources Protection Strategy

  7. A marketingeszközök és –tevékenységek részvényesi értékre gyakorolt hatása (The effect of marketing assets and activities on shareholder value)

    Kovács, Kármen; Kuti, Mónika

    2012-01-01

    A vállalati marketing pénzügyi teljesítményre, különösen részvényesi értékre gyakorolt hatásának kimutatása mind fontosabbá válik a marketingráfordítások nagyságának növekedésével, valamint annak felismerésével, hogy a részvényesek számára vevői érték nélkül nem lehet hosszú távon értéket biztosítani, azonban kedvező piaci eredményekkel sem feltétlenül valósul meg a pénzügyi teljesítmény növekedése. A szerzők tanulmányukban a marketingeszközök és -tevékenységek részvényesi értékre...

  8. Integration of Bioorthogonal Probes and Q-FRET for the Detection of Histone Acetyltransferase Activity.

    Han, Zhen; Luan, Yepeng; Zheng, Yujun George

    2015-12-01

    Histone acetyltransferases (HATs) are key players in the epigenetic regulation of gene function. The recent discovery of diverse HAT substrates implies a broad spectrum of cellular functions of HATs. Many pathological processes are also intimately associated with the dysregulation of HAT levels and activities. However, detecting the enzymatic activity of HATs has been challenging, and this has significantly impeded drug discovery. To advance the field, we developed a convenient one-pot, mix-and-read strategy that is capable of directly detecting the acylated histone product through a fluorescent readout. The strategy integrates three technological platforms-bioorthogonal HAT substrate labeling, alkyne-azide click chemistry, and quenching FRET-into one system for effective probing of HAT enzyme activity. PMID:26455821

  9. HATS-5b: A Transiting hot-Saturn from the HATSouth Survey

    Zhou, G; Penev, K; Bakos, G Á; Hartman, J D; Jordán, A; Mancini, L; Mohler, M; Csubry, Z; Ciceri, S; Brahm, R; Rabus, M; Buchhave, L; Henning, T; Suc, V; Espinoza, N; Béky, B; Noyes, R W; Schmidt, B; Butler, R P; Shectman, S; Thompson, I; Crane, J; Sato, B; Csák, B; Lázár, J; Papp, I; Sári, P; Nikolov, N

    2014-01-01

    We report the discovery of HATS-5b, a transiting hot-Saturn orbiting a G type star, by the HAT-South survey. HATS-5b has a mass of Mp=0.24 Mj, radius of Rp=0.91 Rj, and transits its host star with a period of P=4.7634d. The radius of HATS-5b is consistent with both theoretical and empirical models. The host star has a V band magnitude of 12.6, mass of 0.94 Msun, and radius of 0.87 Rsun. The relatively high scale height of HATS-5b, and the bright, photometrically quiet host star, make this planet a favourable target for future transmission spectroscopy follow-up observations. We reexamine the correlations in radius, equilibrium temperature, and metallicity of the close-in gas-giants, and find hot Jupiter-mass planets to exhibit the strongest dependence between radius and equilibrium temperature. We find no significant dependence in radius and metallicity for the close-in gas-giant population.

  10. Schizosaccharomyces pombe Hat1 (Kat1) is associated with Mis16 and is required for telomeric silencing.

    Tong, Kevin; Keller, Thomas; Hoffman, Charles S; Annunziato, Anthony T

    2012-09-01

    The Hat1 histone acetyltransferase has been implicated in the acetylation of histone H4 during chromatin assembly. In this study, we have characterized the Hat1 complex from the fission yeast Schizosaccharomyces pombe and have examined its role in telomeric silencing. Hat1 is found associated with the RbAp46 homologue Mis16, an essential protein. The Hat1 complex acetylates lysines 5 and 12 of histone H4, the sites that are acetylated in newly synthesized H4 in a wide range of eukaryotes. Deletion of hat1 in S. pombe is itself sufficient to cause the loss of silencing at telomeres. This is in contrast to results obtained with an S. cerevisiae hat1Δ strain, which must also carry mutations of specific acetylatable lysines in the H3 tail domain for loss of telomeric silencing to occur. Notably, deletion of hat1 from S. pombe resulted in an increase of acetylation of histone H4 in subtelomeric chromatin, concomitant with derepression of this region. A similar loss of telomeric silencing was also observed after growing cells in the presence of the deacetylase inhibitor trichostatin A. However, deleting hat1 did not cause loss of silencing at centromeres or the silent mating type locus. These results point to a direct link between Hat1, H4 acetylation, and the establishment of repressed telomeric chromatin in fission yeast. PMID:22771823

  11. Schizosaccharomyces pombe Hat1 (Kat1) Is Associated with Mis16 and Is Required for Telomeric Silencing

    Tong, Kevin; Keller, Thomas; Hoffman, Charles S.; Anthony T. Annunziato

    2012-01-01

    The Hat1 histone acetyltransferase has been implicated in the acetylation of histone H4 during chromatin assembly. In this study, we have characterized the Hat1 complex from the fission yeast Schizosaccharomyces pombe and have examined its role in telomeric silencing. Hat1 is found associated with the RbAp46 homologue Mis16, an essential protein. The Hat1 complex acetylates lysines 5 and 12 of histone H4, the sites that are acetylated in newly synthesized H4 in a wide range of eukaryotes. Del...

  12. Remedial Action Plan and site design for stabilization of the inactive uranium mill tailings site at Mexican Hat, Utah: Text, Appendices A--C. Final report

    NONE

    1988-07-01

    This Remedial Action Plan (RAP) has been developed to serve a two- fold purpose. It presents the activities proposed by the Department of Energy (DOE) to accomplish long-term stabilization and control of the residual radioactive materials (RRM) from Monument Valley Arizona, and Mexican Hat, Utah, at the Mexican Hat disposal site. It also serves to document the concurrence of both the Navajo Nation and the Nuclear Regulatory Commission (NRC) in the remedial action. This agreement, upon execution by DOE and the Navajo Nation and concurrence by the NRC, becomes Appendix B of the Cooperative Agreement. This document has been structured to provide a comprehensive understanding of the remedial action proposed for the Monument Valley and Mexican Hat sites. It includes specific design and construction requirements for the remedial action. Pertinent information and data are included with reference given to the supporting documents. Appendices A,B, and C are provided as part of this document. Appendix A presents regulatory compliance issues, Appendix B provides details of the engineering design, and Appendix C presents the radiological support plan.

  13. An Analytical Model for Top-Hat Long Transient Mode-Mismatched Thermal Lens Spectroscopy

    Sabaeian, M.; Rezaei, H.

    2016-02-01

    It has been shown that a top-hat excitation beam gives rise to a more sensitive signal for the thermal lens spectroscopy (TLS). Recently, a numerical model has been presented for a top- hat excitation beam in a dual-beam mod-mismatched TLS [Opt. Lett. 33(13), 1464-1466 (2008)]. In this work, we present a full analytical version of this model. Our model was based on a new solution of time-dependent heat equation for a finite radius cylindrical sample exposed to a top-hat excitation laser beam. The Fresnel diffraction integration method was then used to calculate on-axis probe-beam intensity variations due to thermal lensing by taking the aberrant nature of the thermal lens into account. The model was confirmed with experimental data of LSCAS-2 with an excellent agreement.

  14. Measurement of nonlinear index by a relay-imaged top-hat Z-scan technique

    Measurements of the nonlinear index of a number of optical materials of interest for the National Ignition Facility have been performed at 1,064 nm and 355 nm by a modified version of the ''top-hat'' technique and the results compared with the more standard gaussian-beam Z-scan technique. The top-hat technique has the advantages of higher sensitivity and smaller uncertainties introduced by beam-quality considerations. The authors have made what they feel to be an additional improvement by placing the defining aperture for the top hat at the front focal plane of the lens that focuses the beam into the sample and then reimaging the input aperture with a second lens onto a ccd camera. Reimaging eliminates diffraction fringes and provides a stationary image even for a wedged sample; recording the entire image permits minimization of spurious effects such as varying interference fringes

  15. Gauge invariant definition of the jet quenching parameter $\\hat{q}$

    Benzke, Michael

    2012-01-01

    We use the framework of Glauber extended Soft-Collinear Effective Theory to explicitly derive a gauge invariant expression of the jet quenching parameter $\\hat{q}$. The effective theory approach offers a systematic power counting scheme at the Lagrangian level and allows for a consistent treatment of the relevant scales in the problem. Employing this approach in a covariant gauge scenario lead to an expression for $\\hat{q}$ containing the expectation value of two light-cone Wilson lines. We find that in a general gauge, additional interaction terms in the Lagrangian have to be considered, leading to the introduction of transverse gauge links.

  16. The effect of hat on phototherapy-induced hypocalcemia in jaundiced full-term neonates

    Ezzeldin Z

    2015-08-01

    Full Text Available Zahraa Ezzeldin, Yasmeen Mansi, Tamer A Abdelhamid, Mohamed Sabry Department of Pediatrics, Faculty of Medicine, Cairo University, Giza, Egypt Background: It has been hypothesized that phototherapy leads to increased calcium absorption by the bones through irradiating the pineal gland and reducing melatonin level. There is some evidence that the use of a stockinet cap to cover the head prevents phototherapy-induced hypocalcemia. Study design: This was a randomized controlled trial, including 124 full-term neonates, weighing >2,500 g, in the first 7 days of life, who developed a bilirubin level ranging from 15 to 20 mg/dL and needed treatment with phototherapy. Our neonates were divided into two groups: Group A without the hat, and Group B with the hat. We designed a dark-colored hat that covered the entire head, including the occipital area, ears, and neck, to prevent passage of light. The hat was used from the time of admission and for the 48 hours of treatment with phototherapy. Ca levels were measured on admission and after 48 hours of phototherapy. The variables were compared using Student’s t-test, chi-square test, and the repeated-measures test. Results: There was no difference in the mean Ca levels in the two groups on admission. However, after 48 hours of phototherapy, there was a trend toward an increased Ca level in the group with the hat; 8.74±0.95 mg/dL vs 8.51±0.24 mg/dL in the control group. Moreover, there was a statistically significant decrease in the incidence of neonates with hypocalcemia in Group B (with hat in only six cases (9.7%, compared to 15 cases (24.2% in Group A (without hat; P=0.031. Conclusion: Phototherapy-induced hypocalcemia can be prevented by covering the head during phototherapy. This seems to be a safe, effective, and cheap method to prevent hypocalcemia and its complications, with no need for prophylactic administration of calcium. Keywords: neonatal jaundice, phototherapy-induced hypocalcemia, hat

  17. Red Hat Enterprise Virtualization - KVM-based infrastructure services at BNL

    Cortijo, D.

    2011-06-14

    Over the past 18 months, BNL has moved a large percentage of its Linux-based servers and services into a Red Hat Enterprise Virtualization (RHEV) environment. This presentation will address our approach to virtualization, critical decision points, and a discussion of our implementation. Specific topics will include an overview of hardware and software requirements, networking, and storage; discussion of the decision of Red Hat solution over competing products (VMWare, Xen, etc); details on some of the features of RHEV - both current and on their roadmap; Review of performance and reliability gains since deployment completion; path forward for RHEV at BNL and caveats and potential problems.

  18. Virtual Screening of Phytochemicals to Novel Target (HAT) Rtt109 in Pneumocystis Jirovecii using Bioinformatics Tools

    Adithavarman, Abhinand Ponneri; Dakshinamoorthi, Anusha; David, Darling Chellathai; Ragunath, Padmavathi Kannan

    2016-01-01

    Introduction Pneumocystis jirovecii is a fungus that causes Pneumocystis pneumonia in HIV and other immunosuppressed patients. Treatment of Pneumocystis pneumonia with the currently available antifungals is challenging and associated with considerable adverse effects. There is a need to develop drugs against novel targets with minimal human toxicities. Histone Acetyl Transferase (HAT) Rtt109 is a potential therapeutic target in Pneumocystis jirovecii species. HAT is linked to transcription and is required to acetylate conserved lysine residues on histone proteins by transferring an acetyl group from acetyl CoA to form e-N-acetyl lysine. Therefore, inhibitors of HAT can be useful therapeutic options in Pneumocystis pneumonia. Aim To screen phytochemicals against (HAT) Rtt109 using bioinformatics tool. Materials and Methods The tertiary structure of Pneumocystis jirovecii (HAT) Rtt109 was modeled by Homology Modeling. The ideal template for modeling was obtained by performing Psi BLAST of the protein sequence. Rtt109-AcCoA/Vps75 protein from Saccharomyces cerevisiae (PDB structure 3Q35) was chosen as the template. The target protein was modeled using Swiss Modeler and validated using Ramachandran plot and Errat 2. Comprehensive text mining was performed to identify phytochemical compounds with antipneumonia and fungicidal properties and these compounds were filtered based on Lipinski’s Rule of 5. The chosen compounds were subjected to virtual screening against the target protein (HAT) Rtt109 using Molegro Virtual Docker 4.5. Osiris Property Explorer and Open Tox Server were used to predict ADME-T properties of the chosen phytochemicals. Results Tertiary structure model of HAT Rtt 109 had a ProSA score of -6.57 and Errat 2 score of 87.34. Structure validation analysis by Ramachandran plot for the model revealed 97% of amino acids were in the favoured region. Of all the phytochemicals subjected to virtual screening against the target protein (HAT) Rtt109, baicalin

  19. Characterization of the atmosphere of the hot Jupiter HAT-P-32Ab and the M-dwarf companion HAT-P-32B

    Zhao, Ming; Wright, Jason T; Knutson, Heather A; Burrows, Adam; Fortney, Johnathan; Ngo, Henry; Fulton, Benjamin J; Baranec, Christoph; Riddle, Reed; Law, Nicholas M; Muirhead, Philip S; Hinkley, Sasha; Showman, Adam P; Curtis, Jason; Burruss, Rick

    2014-01-01

    We report secondary eclipse photometry of the hot Jupiter HAT-P-32Ab, taken with Hale/WIRC in H and Ks bands and with Spitzer/IRAC at 3.6 and 4.5 micron. We carried out adaptive optics imaging of the planet host star HAT-P-32A and its companion HAT-P-32B in the near-IR and the visible. We clearly resolve the two stars from each other and find a separation of 2.923" +/- 0. 004" and a position angle 110.64 deg +/- 0.12 deg. We measure the flux ratios of the binary in g' r' i' z' and H & Ks bands, and determine Teff = 3565 +/- 82 K for the companion star, corresponding to an M1.5 dwarf. We use PHOENIX stellar atmosphere models to correct the dilution of the secondary eclipse depths of the hot Jupiter due to the presence of the M1.5 companion. We also improve the secondary eclipse photometry by accounting for the non-classical, flux-dependent nonlinearity of the WIRC IR detector in the H band. We measure planet-to-star flux ratios of 0.090 +/- 0.033%, 0.178 +/- 0.057%, 0.364 +/- 0.016%, and 0.438 +/- 0.020% i...

  20. WASP-35b, WASP-48b, AND HAT-P-30b/WASP-51b: TWO NEW PLANETS AND AN INDEPENDENT DISCOVERY OF A HAT PLANET

    We report the detection of WASP-35b, a planet transiting a metal-poor ([Fe/H] = -0.15) star in the Southern hemisphere, WASP-48b, an inflated planet which may have spun-up its slightly evolved host star of 1.75 Rsun in the Northern hemisphere, and the independent discovery of HAT-P-30b/WASP-51b, a new planet in the Northern hemisphere. Using WASP, RISE, Faulkes Telescope South, and TRAPPIST photometry, with CORALIE, SOPHIE, and NOT spectroscopy, we determine that WASP-35b has a mass of 0.72 ± 0.06 MJ and radius of 1.32 ± 0.05RJ , and orbits with a period of 3.16 days, WASP-48b has a mass of 0.98 ± 0.09 MJ , radius of 1.67 ± 0.10 RJ , and orbits in 2.14 days, while HAT-P-30b/WASP-51b, with an orbital period of 2.81 days, is found to have a mass of 0.76 ± 0.05 MJ and radius of 1.42 ± 0.03 RJ , agreeing with values of 0.71 ± 0.03 MJ and 1.34 ± 0.07 RJ reported for HAT-P-30b.

  1. Boundary state of $U_q(\\hat{gl}(N|N))$ analog of half-infinite $t-J$ model

    Kojima, Takeo

    2015-01-01

    The $U_q(\\hat{gl}(N|N))$-analog of the half-infinite $t-J$ model with a boundary is considered by using the vertex operator approach. We find explicit bosonic formula of the boundary state in the integrable highest-weight module over the quantum superalgebra $U_q(\\hat{gl}(N|N))$.

  2. THE EFFECT OF DRAMA TECHNIQUE WITH SIX HATS ON THE STUDENTS’ ACHIEVEMENT IN GERMAN STUDIES

    Bülent KIRMIZI

    2012-06-01

    Full Text Available Subjects in German Lessons which start in the tenth class in Anatolian High Schools are generally studied by using explanation and question-answer methods. These methods are teacher focused methods since these depend on the presentation teaching strategies. In this survey, the Effect on success of two methods which are the drama technique with six hats wich enable the students to use their mental abilities and presantative explanation technique in wich the students are passive is searched. In the base of Edward de Bono’s drama technique with six hats, we tell our ideas by wearing different colored hats wich symbolize six different angles of view. And by doing this we can increase our creativity. Evaluatin questionnaires have been sperated to the students to get the data and after explaining the subjects, test has been done. It has been established that success in the classes in which drama technique with six hats has been used is much higher than that of other classes.

  3. A q-analogue of gl-hat3 hierarchy and q-Painlev? VI

    A q-analogue of the gl-hat3 Drinfel'd-Sokolov hierarchy is proposed as a reduction of the q-KP hierarchy. Applying a similarity reduction and a q-Laplace transformation to the hierarchy, one can obtain the q-Painleve VI equation proposed by Jimbo and Sakai

  4. Comparison of Protein Acetyltransferase Action of CRTAase with the Prototypes of HAT

    Prija Ponnan

    2014-01-01

    Full Text Available Our laboratory is credited for the discovery of enzymatic acetylation of protein, a phenomenon unknown till we identified an enzyme termed acetoxy drug: protein transacetylase (TAase, catalyzing the transfer of acetyl group from polyphenolic acetates to receptor proteins (RP. Later, TAase was identified as calreticulin (CR, an endoplasmic reticulum luminal protein. CR was termed calreticulin transacetylase (CRTAase. Our persistent study revealed that CR like other families of histone acetyltransferases (HATs such as p300, Rtt109, PCAF, and ESA1, undergoes autoacetylation. The autoacetylated CR was characterized as a stable intermediate in CRTAase catalyzed protein acetylation, and similar was the case with ESA1. The autoacetylation of CR like that of HATs was found to enhance protein-protein interaction. CR like HAT-1, CBP, and p300 mediated the acylation of RP utilizing acetyl CoA and propionyl CoA as the substrates. The similarities between CRTAase and HATs in mediating protein acylation are highlighted in this review.

  5. WASP-12b and HAT-P-8b are Members of Triple Star Systems

    Bechter, Eric B; Ngo, Henry; Knutson, Heather A; Batygin, Konstantin; Hinkley, Sasha; Muirhead, Phillip S; Johnson, John Asher; Howard, Andrew W; Montet, Benjamin T; Matthews, Christopher T; Morton, Timothy D

    2013-01-01

    We present high spatial resolution images that demonstrate the hot Jupiters WASP-12b and HAT-P-8b orbit the primary star of hierarchical triple star systems. In each case, two distant companions with colors and brightness consistent with M dwarfs co-orbit the planet host as well as one another. Our adaptive optics images spatially resolve the secondary around WASP-12, previously identified by Bergfors et al. 2011 and Crossfield et al. 2012, into two distinct sources separated by 84.3+/-0.6 mas (21 +/- 3 AU). We find that the secondary to HAT-P-8, also identified by Bergfors et al. 2011, is in fact composed of two stars separated by 65.3+/-0.5 mas (15+/-1 AU). Our follow-up observations demonstrate physical association through common proper-motion. HAT-P-8 C has a particularly low mass, which we estimate to be 0.18+/-0.02Msun using photometry. Due to their hierarchy, WASP-12 BC and HAT-P-8 BC will enable the first dynamical mass determination for hot Jupiter stellar companions. These previously well-studied pl...

  6. Relation of FER-HDL and AIP to clinical and laboratory parameters in HATS

    Dobiášová, Milada; Frohlich, J. J.; Brown, B.G.; Cheung, C.M.; Alaupovic, P.

    Elsevier. Roč. 6, č. 1 (2005), s. 50-50. ISSN 1567-5688. [Congress of the European Atherosclerosis Society /75./. 23.04.2005-26.04.2005, Prague] Institutional research plan: CEZ:AV0Z50110509 Keywords : FER -HDL * atherogenic index of plasma (AIP) * HDL-Atherosclerosis Treatment Study (HATS) Subject RIV: FA - Cardiovascular Diseases incl. Cardiotharic Surgery

  7. Morphological hat-transform scale spaces and their use in texture classification

    Jalba, A.C.; Roerdink, J.B.T.M.; Wilkinson, M.H.F.

    2003-01-01

    In this paper we present a multi-scale morphological method for use in texture classification. A connected operator similar to the morphological hat-transform is defined, and two scale-space representations are built. The most important features are extracted from the scale spaces by unsupervised cl

  8. HATS-5b: A TRANSITING HOT SATURN FROM THE HATSouth SURVEY

    Zhou, G.; Bayliss, D.; Schmidt, B. [Research School of Astronomy and Astrophysics, Australian National University, Canberra, ACT 2611 (Australia); Penev, K.; Bakos, G. Á.; Hartman, J. D.; Csubry, Z. [Department of Astrophysical Sciences, Princeton University, NJ 08544 (United States); Jordán, A.; Brahm, R.; Rabus, M.; Suc, V.; Espinoza, N. [Departamento de Astronomía y Astrofísica, Pontificia Universidad Católica de Chile, Av. Vicuña Mackenna 4860, 7820436 Macul, Santiago (Chile); Mancini, L.; Mohler, M.; Ciceri, S.; Henning, T. [Max Planck Institute for Astronomy, Heidelberg (Germany); Buchhave, L. [Niels Bohr Institute, Copenhagen University (Denmark); Béky, B.; Noyes, R. W. [Harvard-Smithsonian Center for Astrophysics, Cambridge, MA 02138 (United States); Butler, R. P., E-mail: george.zhou@anu.edu.au [Department of Terrestrial Magnetism, Carnegie Institution of Washington, 5241 Broad Branch Road NW, Washington, DC 20015-1305 (United States); and others

    2014-06-01

    We report the discovery of HATS-5b, a transiting hot Saturn orbiting a G-type star, by the HATSouth survey. HATS-5b has a mass of M{sub p} ≈ 0.24 M {sub J}, radius of R{sub p} ≈ 0.91 R {sub J}, and transits its host star with a period of P ≈ 4.7634 days. The radius of HATS-5b is consistent with both theoretical and empirical models. The host star has a V-band magnitude of 12.6, mass of 0.94 M {sub ☉}, and radius of 0.87 R {sub ☉}. The relatively high scale height of HATS-5b and the bright, photometrically quiet host star make this planet a favorable target for future transmission spectroscopy follow-up observations. We reexamine the correlations in radius, equilibrium temperature, and metallicity of the close-in gas giants and find hot Jupiter-mass planets to exhibit the strongest dependence between radius and equilibrium temperature. We find no significant dependence in radius and metallicity for the close-in gas giant population.

  9. Atmospheric circulation of eccentric hot Jupiter HAT-P-2B

    Lewis, Nikole K. [Department of Earth, Atmospheric and Planetary Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139 (United States); Showman, Adam P. [Department of Planetary Sciences and Lunar and Planetary Laboratory, The University of Arizona, Tucson, AZ 85721 (United States); Fortney, Jonathan J. [Department of Astronomy and Astrophysics, University of California, Santa Cruz, CA 95064 (United States); Knutson, Heather A. [Division of Geological and Planetary Sciences, California Institute of Technology, Pasadena, CA 91125 (United States); Marley, Mark S., E-mail: nklewis@mit.edu [NASA Ames Research Center 245-3, Moffett Field, CA 94035 (United States)

    2014-11-10

    The hot Jupiter HAT-P-2b has become a prime target for Spitzer Space Telescope observations aimed at understanding the atmospheric response of exoplanets on highly eccentric orbits. Here we present a suite of three-dimensional atmospheric circulation models for HAT-P-2b that investigate the effects of assumed atmospheric composition and rotation rate on global scale winds and thermal patterns. We compare and contrast atmospheric models for HAT-P-2b, which assume one and five times solar metallicity, both with and without TiO/VO as atmospheric constituents. Additionally we compare models that assume a rotation period of half, one, and two times the nominal pseudo-synchronous rotation period. We find that changes in assumed atmospheric metallicity and rotation rate do not significantly affect model predictions of the planetary flux as a function of orbital phase. However, models in which TiO/VO are present in the atmosphere develop a transient temperature inversion between the transit and secondary eclipse events that results in significant variations in the timing and magnitude of the peak of the planetary flux compared with models in which TiO/VO are omitted from the opacity tables. We find that no one single atmospheric model can reproduce the recently observed full orbit phase curves at 3.6, 4.5 and 8.0 μm, which is likely due to a chemical process not captured by our current atmospheric models for HAT-P-2b. Further modeling and observational efforts focused on understanding the chemistry of HAT-P-2b's atmosphere are needed and could provide key insights into the interplay between radiative, dynamical, and chemical processes in a wide range of exoplanet atmospheres.

  10. How a hat may affect 3-month-olds' recognition of a face: an eye-tracking study.

    Hermann Bulf

    Full Text Available Recent studies have shown that infants' face recognition rests on a robust face representation that is resilient to a variety of facial transformations such as rotations in depth, motion, occlusion or deprivation of inner/outer features. Here, we investigated whether 3-month-old infants' ability to represent the invariant aspects of a face is affected by the presence of an external add-on element, i.e. a hat. Using a visual habituation task, three experiments were carried out in which face recognition was investigated by manipulating the presence/absence of a hat during face encoding (i.e. habituation phase and face recognition (i.e. test phase. An eye-tracker system was used to record the time infants spent looking at face-relevant information compared to the hat. The results showed that infants' face recognition was not affected by the presence of the external element when the type of the hat did not vary between the habituation and test phases, and when both the novel and the familiar face wore the same hat during the test phase (Experiment 1. Infants' ability to recognize the invariant aspects of a face was preserved also when the hat was absent in the habituation phase and the same hat was shown only during the test phase (Experiment 2. Conversely, when the novel face identity competed with a novel hat, the hat triggered the infants' attention, interfering with the recognition process and preventing the infants' preference for the novel face during the test phase (Experiment 3. Findings from the current study shed light on how faces and objects are processed when they are simultaneously presented in the same visual scene, contributing to an understanding of how infants respond to the multiple and composite information available in their surrounding environment.

  11. How a hat may affect 3-month-olds' recognition of a face: an eye-tracking study.

    Bulf, Hermann; Valenza, Eloisa; Turati, Chiara

    2013-01-01

    Recent studies have shown that infants' face recognition rests on a robust face representation that is resilient to a variety of facial transformations such as rotations in depth, motion, occlusion or deprivation of inner/outer features. Here, we investigated whether 3-month-old infants' ability to represent the invariant aspects of a face is affected by the presence of an external add-on element, i.e. a hat. Using a visual habituation task, three experiments were carried out in which face recognition was investigated by manipulating the presence/absence of a hat during face encoding (i.e. habituation phase) and face recognition (i.e. test phase). An eye-tracker system was used to record the time infants spent looking at face-relevant information compared to the hat. The results showed that infants' face recognition was not affected by the presence of the external element when the type of the hat did not vary between the habituation and test phases, and when both the novel and the familiar face wore the same hat during the test phase (Experiment 1). Infants' ability to recognize the invariant aspects of a face was preserved also when the hat was absent in the habituation phase and the same hat was shown only during the test phase (Experiment 2). Conversely, when the novel face identity competed with a novel hat, the hat triggered the infants' attention, interfering with the recognition process and preventing the infants' preference for the novel face during the test phase (Experiment 3). Findings from the current study shed light on how faces and objects are processed when they are simultaneously presented in the same visual scene, contributing to an understanding of how infants respond to the multiple and composite information available in their surrounding environment. PMID:24349378

  12. HATS-17b: A Transiting Compact Warm Jupiter in a 16.3 Day Circular Orbit

    Brahm, R.; Jordán, A.; Bakos, G. Á.; Penev, K.; Espinoza, N.; Rabus, M.; Hartman, J. D.; Bayliss, D.; Ciceri, S.; Zhou, G.; Mancini, L.; Tan, T. G.; de Val-Borro, M.; Bhatti, W.; Csubry, Z.; Bento, J.; Henning, T.; Schmidt, B.; Rojas, F.; Suc, V.; Lázár, J.; Papp, I.; Sári, P.

    2016-04-01

    We report the discovery of HATS-17b, the first transiting warm Jupiter of the HATSouth network. HATS-17b transits its bright (V = 12.4) G-type ({M}\\star = 1.131+/- 0.030 {M}⊙ , {R}\\star = {1.091}-0.046+0.070 {R}⊙ ) metal-rich ([Fe/H] = +0.3 dex) host star in a circular orbit with a period of P = 16.2546 days. HATS-17b has a very compact radius of 0.777+/- 0.056 {R}{{J}} given its Jupiter-like mass of 1.338+/- 0.065 {M}{{J}}. Up to 50% of the mass of HATS-17b may be composed of heavy elements in order to explain its high density with current models of planetary structure. HATS-17b is the longest period transiting planet discovered to date by a ground-based photometric survey, and is one of the brightest transiting warm Jupiter systems known. The brightness of HATS-17 will allow detailed follow-up observations to characterize the orbital geometry of the system and the atmosphere of the planet. The HATSouth network is operated by a collaboration consisting of Princeton University (PU), the Max Planck Institute für Astronomie (MPIA), the Australian National University (ANU), and the Pontificia Universidad Católica de Chile (PUC). The station at Las Campanas Observatory (LCO) of the Carnegie Institute is operated by PU in conjunction with PUC, the station at the High Energy Spectroscopic Survey (H.E.S.S.) site is operated in conjunction with MPIA, and the station at Siding Spring Observatory (SSO) is operated jointly with ANU. This paper includes data gathered with the MPG 2.2 m telescope at the ESO Observatory in La Silla and with the 3.9 m AAT in Siding Spring Observatory. This paper uses observations obtained with facilities of the Las Cumbres Observatory Global Telescope. Based on observations taken with the HARPS spectrograph (ESO 3.6 m telescope at La Silla) under programme 097.C-0571.

  13. Two-dimensional 'hat-scratch' periodic structures induced by a single femtosecond laser pulse on silica glass

    Two-dimensional 'hat-scratch' structures are fabricated on silica glass by the interference of three non-coplanar beams originating from a single femtosecond laser pulse. The scanning electron microscope (SEM) characterizations show that the as-formed structures are composed of hat holes and scratch marks. The experimental results indicate that the structures are dependent on the intensity of laser beam. The formation of the two-dimensional 'hat-scratch' structures is mainly due to the combined laser ablation effects including ionization, shock wave, plasma expansion, and phase explosion.

  14. High multiplicity processes at NLO with BlackHat and Sherpa

    Bern, Zvi; Dixon, Lance J; Hoeche, Stefan; Cordero, Fernando Febres; Ita, Harald; Kosower, David; Maître, Daniel

    2012-01-01

    In this contribution we review recent progress with fixed-order QCD predictions for the production of a vector boson in association with jets at hadron colliders, using the programs BlackHat and SHERPA. We review general features of next-to-leading-order (NLO) predictions for the production of a massive vector boson in association with four jets. We also discuss how precise descriptions of vector-boson production can be applied to the determination of backgrounds to new physics signals. Here we focus on data-driven backgrounds to a missing-energy-plus-jets search performed by CMS. Finally, we review recent progress in developing theoretical tools for high-multiplicity loop-computation within the BlackHat-library. In particular, we discuss methods for handling the color degrees of freedom in multi-jet predictions at NLO.

  15. Potential ground water resources of Hat Yai Basin in Peninsular Thailand by gravity study

    Warawutti Lohawijarn

    2005-05-01

    Full Text Available Residual gravity anomaly with a minimum of about -140 mm s-2 with approximately NS trend and a limited axial length was observed over Hat Yai Basin in Peninsular Thailand. The modeled Hat Yai basin is about 1 km deep at its deepest, 60 km long and 20 km wide. The porosity of basin sediment and the amount of potential ground water reserves within the basin are estimated to be 39% and 121.7±0.8 km3 respectively, assuming full saturation. Within the topmost 80 m of ground where the present extraction is concentrated, the estimated ground water reserve is 12.5±0.5 km3.

  16. Change in Visual Perception and Balance Caused by Different Types of Hat

    Roh, Hyolyun

    2014-01-01

    [Purpose] This study aimed to determine the effect of the type of hat worn on balance, eye-hand coordination, and visual perception of normal adults. [Subjects and Methods] Eight healthy male (20.87±1.95 years, 171.38±4.03 cm, 60.75±7.94 kg) and seven female (20.14±0.89 years, 160.57±5.25 cm, 57.14±7.92 kg) university students participated in this study. Balance ability, eye-hand coordination, and visual perception were measured when subjects were bare-headed, and when they wore a hat, cap or...

  17. Measure of image clarity using image features extracted by the multiscale top-hat transform

    To correctly quantify the clarity of an image and achieve good discrimination, an effective measure of image clarity using the image features extracted by the multiscale top-hat transform is presented in this paper. Firstly, multiscale image features are extracted by the top-hat transform using multiscale structuring elements. Then, the final extracted image features for constructing the measure of image clarity are obtained from the extracted multiscale image features. Finally, the mean value of the final extracted image features is calculated as the proposed measure of image clarity. Comparison experiments and application to image clarity enhancement of mineral images show that the proposed measure is effective for measuring image clarity and has good discrimination ability compared with some other measures. Therefore, the proposed image clarity measure may be used for different applications such as automatic focusing in microscopy, image enhancement, image fusion and so on. (paper)

  18. Home Automated Telemanagement (HAT) System to Facilitate Self-Care of Patients with Chronic Diseases

    Joseph Finkelstein; Rajesh Khare; Deepal Vora

    2003-01-01

    Successful patient self-management requires a multidisciplinary approach that includes regular patient assessment, disease-specific education, control of medication adherence, implementation of health behavior change models and social support. Existing systems for computer-assisted disease management do not provide this multidisciplinary patient support and do not address treatment compliance issues. We developed the Home Automated Telemanagement (HAT) system for patients with different chron...

  19. Self-assembled ordered structures in thin films of HAT5 discotic liquid crystal

    Piero Morales; Jan Lagerwall; Paolo Vacca; Sabine Laschat; Giusy Scalia

    2010-01-01

    Thin films of the discotic liquid crystal hexapentyloxytriphenylene (HAT5), prepared from solution via casting or spin-coating, were investigated by atomic force microscopy and polarizing optical microscopy, revealing large-scale ordered structures substantially different from those typically observed in standard samples of the same material. Thin and very long fibrils of planar-aligned liquid crystal were found, possibly formed as a result of an intermediate lyotropic nematic state arising d...

  20. Automatic Image Registration Using Mexican Hat Wavelet, Invariant Moment, and Radon Transform

    Jignesh N Sarvaiya; Dr. Suprava Patnaik

    2011-01-01

    Image registration is an important and fundamental task in image processing used to match two different images. Given two or more different images to be registered, image registration estimates the parameters of the geometrical transformation model that maps the sensed images back to its reference image. A feature-based approach to automated image-to-image registration is presented. The characteristic of this approach is that it combines Mexican-Hat Wavelet, Invariant Moments and Radon Transf...

  1. HATS-4b: A Dense Hot-Jupiter Transiting a Super Metal-Rich G Star

    Jordán, A; Bakos, G Á; Bayliss, D; Penev, K; Hartman, J D; Zhou, G; Mancini, L; Mohler-Fischer, M; Ciceri, S; Sato, B; Csubry, Z; Rabus, M; Suc, V; Espinoza, N; Bhatti, W; Borro, M de Val; Buchhave, L; Csák, B; Henning, T; Schmidt, B; Tan, T G; Noyes, R W; Béky, B; Butler, R P; Shectman, S; Crane, J; Thompson, I; Williams, A; Martin, R; Contreras, C; Lázár, J; Papp, I; Sári, P

    2014-01-01

    We report the discovery by the HATSouth survey of HATS-4b, an extrasolar planet transiting a V=13.46 mag G star. HATS-4b has a period of P = 2.5167 d, mass of Mp = 1.32 Mj, radius of Rp = 1.02 Rj and density of rho_p = 1.55 +- 0.16 g/cm^3 ~ 1.24 rhoj. The host star has a mass of 1.00 Msun, a radius of 0.92 Rsun and a very high metallicity [Fe/H]= 0.43 +- 0.08. HATS-4b is among the densest known planets with masses between 1-2 Mj and is thus likely to have a significant content of heavy elements of the order of 75 Mearth. In this paper we present the data reduction, radial velocity measurement and stellar classification techniques adopted by the HATSouth survey for the CORALIE spectrograph. We also detail a technique to estimate simultaneously vsini and macroturbulence using high resolution spectra.

  2. HAT-P-25b: a Hot-Jupiter Transiting a Moderately Faint G Star

    Quinn, S N; Hartman, J; Torres, G; Kovács, G; Latham, D W; Noyes, R W; Fischer, D A; Johnson, J A; Marcy, G W; Howard, A W; Szentgyorgyi, A; Fürész, G; Buchhave, L A; Béky, B; Sasselov, D D; Stefanik, R P; Perumpilly, G; Everett, M; Lázár, J; Papp, I; Sári, P

    2010-01-01

    We report the discovery of HAT-P-25b, a transiting extrasolar planet orbiting the V = 13.19 G5 dwarf star GSC 1788-01237, with a period P = 3.652836 +/- 0.000019 days, transit epoch Tc = 2455176.85173 +/- 0.00047 (BJD), and transit duration 0.1174 +/- 0.0017 days. The host star has mass of 1.01 +/- 0.03 M(Sun), radius of 0.96 +(0.05)-(0.04) R(Sun), effective temperature 5500 +/- 80 K, and metallicity [Fe/H] = +0.31 +/- 0.08. The planetary companion has a mass of 0.567 +/- 0.022 M(Jup), and radius of 1.190 +(0.081)-(0.056) R(Jup) yielding a mean density of 0.42 +/- 0.07 g cm-3. Comparing these observations with recent theoretical models, we find that HAT-P-25b is consistent with a hydrogen-helium dominated gas giant planet with negligible core mass and age 3.2 +/- 2.3 Gyr. The properties of HAT-P-25b support several previously observed correlations for planets in the mass range 0.4 < M < 0.7 M(Jup), including those of core mass vs. metallicity, planet radius vs. equilibrium temperature, and orbital perio...

  3. A spin-orbit alignment for the hot Jupiter HATS-3b

    We have measured the alignment between the orbit of HATS-3b (a recently discovered, slightly inflated Hot Jupiter) and the spin axis of its host star. Data were obtained using the CYCLOPS2 optical-fiber bundle and its simultaneous calibration system feeding the UCLES spectrograph on the Anglo-Australian Telescope. The sky-projected spin-orbit angle of λ = 3° ± 25° was determined from spectroscopic measurements of the Rossiter-McLaughlin effect. This is the first exoplanet discovered through the HATSouth transit survey to have its spin-orbit angle measured. Our results indicate that the orbital plane of HATS-3b is consistent with being aligned to the spin axis of its host star. The low obliquity of the HATS-3 system, which has a relatively hot mid F-type host star, agrees with the general trend observed for Hot Jupiter host stars with effective temperatures >6250 K to have randomly distributed spin-orbit angles.

  4. A Spin-Orbit Alignment for the Hot Jupiter HATS-3b

    Addison, B C; Wright, D J; Bayliss, D

    2014-01-01

    We have measured the alignment between the orbit of HATS-3b (a recently discovered, slightly inflated Hot Jupiter) and the spin-axis of its host star. Data were obtained using the CYCLOPS2 optical-fiber bundle and its simultaneous calibration system feeding the UCLES spectrograph on the Anglo-Australian Telescope. The sky-projected spin-orbit angle of $\\lambda = 3\\pm25^{\\circ}$ was determined from spectroscopic measurements of Rossiter-McLaughlin effect. This is the first exoplanet discovered through the HATSouth transit survey to have its spin-orbit angle measured. Our results indicate that the orbital plane of HATS-3b is consistent with being aligned to the spin axis of its host star. The low obliquity of the HATS-3 system, which has a relatively hot mid F-type host star, agrees with the general trend observed for Hot Jupiter host stars with effective temperatures $>6250$K to have randomly distributed spin-orbit angles.

  5. HATS-18 b: An Extreme Short--Period Massive Transiting Planet Spinning Up Its Star

    Penev, Dr Kaloyan M; Bakos, Dr Gaspar A; Ciceri, Ms Simona; Brahm, Dr Rafael; Bayliss, Dr Daniel; Bento, Joao; Jord'an, Andr'es; Csubry, Mr Zoltan; Bhatti, W; de Val-Borro, Miguel; Espinoza, Mr Néstor; Zhou, Dr George; Mancini, Dr Luigi; Rabus, Dr Markus; Suc, Vincent; Henning, Thomas; Schmidt, Prof Brian P; Noyes, Dr Robert W; L'az'ar, J; Papp, Istvan; S'ari, P

    2016-01-01

    We report the discovery by the HATSouth network of HATS-18 b: a 1.980 +/- 0.077 Mj, 1.337 +0.102 -0.049 Rj planet in a 0.8378 day orbit, around a solar analog star (mass 1.037 +/- 0.047 Msun, and radius 1.020 +0.057 -0.031 Rsun) with V=14.067 +/- 0.040 mag. The high planet mass, combined with its short orbital period, implies strong tidal coupling between the planetary orbit and the star. In fact, given its inferred age, HATS-18 shows evidence of significant tidal spin up, which together with WASP-19 (a very similar system) allows us to constrain the tidal quality factor for Sun-like stars to be in the range 6.5 <= lg(Q*/k_2) <= 7 even after allowing for extremely pessimistic model uncertainties. In addition, the HATS-18 system is among the best systems (and often the best system) for testing a multitude of star--planet interactions, be they gravitational, magnetic or radiative, as well as planet formation and migration theories.

  6. iHAT: interactive Hierarchical Aggregation Table for Genetic Association Data

    Heinrich Julian

    2012-05-01

    Full Text Available Abstract In the search for single-nucleotide polymorphisms which influence the observable phenotype, genome wide association studies have become an important technique for the identification of associations between genotype and phenotype of a diverse set of sequence-based data. We present a methodology for the visual assessment of single-nucleotide polymorphisms using interactive hierarchical aggregation techniques combined with methods known from traditional sequence browsers and cluster heatmaps. Our tool, the interactive Hierarchical Aggregation Table (iHAT, facilitates the visualization of multiple sequence alignments, associated metadata, and hierarchical clusterings. Different color maps and aggregation strategies as well as filtering options support the user in finding correlations between sequences and metadata. Similar to other visualizations such as parallel coordinates or heatmaps, iHAT relies on the human pattern-recognition ability for spotting patterns that might indicate correlation or anticorrelation. We demonstrate iHAT using artificial and real-world datasets for DNA and protein association studies as well as expression Quantitative Trait Locus data.

  7. Atmospheric Circulation of Eccentric Hot Jupiter HAT-P-2b

    Lewis, Nikole K; Fortney, Jonathan J; Knutson, Heather A; Marley, Mark S

    2014-01-01

    The hot-Jupiter HAT-P-2b has become a prime target for Spitzer Space Telescope observations aimed at understanding the atmospheric response of exoplanets on highly eccentric orbits. Here we present a suite of three-dimensional atmospheric circulation models for HAT-P-2b that investigate the effects of assumed atmospheric composition and rotation rate on global scale winds and thermal patterns. We compare and contrast atmospheric models for HAT-P-2b, which assume one and five times solar metallicity, both with and without TiO/VO as atmospheric constituents. Additionally we compare models that assume a rotation period of half, one, and two times the nominal pseudo-synchronous rotation period. We find that changes in assumed atmospheric metallicity and rotation rate do not significantly affect model predictions of the planetary flux as a function of orbital phase. However, models in which TiO/VO are present in the atmosphere develop a transient temperature inversion between the transit and secondary eclipse even...

  8. On variable geometric factor systems for top-hat electrostatic space plasma analyzers

    Even in the relatively small region of space that is the Earth's magnetosphere, ion and electron fluxes can vary by several orders of magnitude. Top-hat electrostatic analyzers currently do not possess the dynamic range required to sample plasma under all conditions. The purpose of this study was to compare, through computer simulation, three new electrostatic methods that would allow the sensitivity of a sensor to be varied through control of its geometric factor (GF) (much like an aperture on a camera). The methods studied were inner filter plates, split hemispherical analyzer (SHA) and top-cap electrode. This is the first discussion of the filter plate concept and also the first study where all three systems are studied within a common analyzer design, so that their relative merits could be fairly compared. Filter plates were found to have the important advantage that they facilitate the reduction in instrument sensitivity whilst keeping all other instrument parameters constant. However, it was discovered that filter plates have numerous disadvantages that make such a system impracticable for a top-hat electrostatic analyzer. It was found that both the top-cap electrode and SHA are promising variable geometric factor system (VGFS) concepts for implementation into a top-hat electrostatic analyzer, each with distinct advantages over the other

  9. On Variable Geometric Factor Systems for Top-Hat Electrostatic Space Plasma Analyzers

    Kataria, Dhiren O.; Collinson, Glyn A.

    2010-01-01

    Even in the relatively small region of space that is the Earth's magnetosphere, ion and electron fluxes can vary by several orders of magnitude. Top-hat electrostatic analyzers currently do not possess the dynamic range required to sample plasma under all conditions. The purpose of this study was to compare, through computer simulation, three new electrostatic methods that would allow the sensitivity of a sensor to be varied through control of its geometric factor (GF) (much like an aperture on a camera). The methods studied were inner filter plates, split hemispherical analyzer (SHA) and top-cap electrode. This is the first discussion of the filter plate concept and also the first study where all three systems are studied within a common analyzer design, so that their relative merits could be fairly compared. Filter plates were found to have the important advantage that they facilitate the reduction in instrument sensitivity whilst keeping all other instrument parameters constant. However, it was discovered that filter plates have numerous disadvantages that make such a system impracticable for a top-hat electrostatic analyzer. It was found that both the top-cap electrode and SHA are promising variable geometric factor system (VGFS) concepts for implementation into a top-hat electrostatic analyzer, each with distinct advantages over the other.

  10. The refined physical parameters of transiting exoplanet system HAT-P-24

    The transiting exoplanet system HAT-P-24 was observed by using CCD cameras at Yunnan Observatory and Hokoon Astronomical Centre, China in 2010 and 2012. In order to enhance the signal to noise ratio of transit events, the observed data are corrected for systematic errors according to Collier Cameron et al.'s coarse de-correlation and Tamuz et al.'s SYSREM algorithms. Three new complete transit light curves are analyzed by means of the Markov chain Monte Carlo technique, and the new physical parameters of the system are derived. They are consistent with the old ones from the discovered paper except for a new larger radius Rp = 1.364 RJ of HAT-P-24b, which confirms its inflated nature. By combining the five available epochs of mid-transit derived from complete transit light curves, the orbital period of HAT-P-24b is refined to P = 3.3552479 d and no obvious transit timing variation signal can be found from these five transit events during 2010–2012

  11. Characterization of the atmosphere of the hot Jupiter HAT-P-32Ab and the M-dwarf companion HAT-P-32B

    Zhao, Ming; Wright, Jason T.; Curtis, Jason [Department of Astronomy and Astrophysics, Pennsylvania State University, PA 16802 (United States); O' Rourke, Joseph G.; Knutson, Heather A.; Ngo, Henry [Division of Geological and Planetary Sciences, California Institute of Technology, Pasadena, CA 91125 (United States); Burrows, Adam [Department of Astrophysical Sciences, Princeton University, 4 Ivy Lane, Princeton, NJ 08544 (United States); Fortney, Johnathan [Department of Astronomy and Astrophysics, University of California, Santa Cruz, CA 95064 (United States); Fulton, Benjamin J.; Baranec, Christoph [Institute for Astronomy, University of Hawai' i at Mānoa, Hilo, HI 96720-2700 (United States); Riddle, Reed; Hinkley, Sasha [Division of Physics, Mathematics, and Astronomy, California Institute of Technology, Pasadena, CA 91125 (United States); Law, Nicholas M. [Department of Physics and Astronomy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-3255 (United States); Muirhead, Philip S. [Department of Astronomy, Boston University, 725 Commonwealth Avenue, Boston, MA 02215 (United States); Showman, Adam P. [Department of Planetary Sciences and Lunar and Planetary Laboratory, The University of Arizona, Tucson, AZ 85721 (United States); Burruss, Rick, E-mail: mingzhao@psu.edu [Jet Propulsion Laboratory, California Institute of Technology, CA 91109 (United States)

    2014-12-01

    We report secondary eclipse photometry of the hot Jupiter HAT-P-32Ab, taken with Hale/Wide-field Infra-Red Camera (WIRC) in H and K{sub S} bands and with Spitzer/IRAC at 3.6 and 4.5 μm. We carried out adaptive optics imaging of the planet host star HAT-P-32A and its companion HAT-P-32B in the near-IR and the visible. We clearly resolve the two stars from each other and find a separation of 2.''923 ± 0.''004 and a position angle 110.°64 ± 0.°12. We measure the flux ratios of the binary in g'r'i'z' and H and K{sub S} bands, and determine T {sub eff}= 3565 ± 82 K for the companion star, corresponding to an M1.5 dwarf. We use PHOENIX stellar atmosphere models to correct the dilution of the secondary eclipse depths of the hot Jupiter due to the presence of the M1.5 companion. We also improve the secondary eclipse photometry by accounting for the non-classical, flux-dependent nonlinearity of the WIRC IR detector in the H band. We measure planet-to-star flux ratios of 0.090% ± 0.033%, 0.178% ± 0.057%, 0.364% ± 0.016%, and 0.438% ± 0.020% in the H, K{sub S} , 3.6 and 4.5 μm bands, respectively. We compare these with planetary atmospheric models, and find they prefer an atmosphere with a temperature inversion and inefficient heat redistribution. However, we also find that the data are equally well described by a blackbody model for the planet with T {sub p} = 2042 ± 50 K. Finally, we measure a secondary eclipse timing offset of 0.3 ± 1.3 minutes from the predicted mid-eclipse time, which constrains e = 0.0072{sub −0.0064}{sup +0.0700} when combined with radial velocity data and is more consistent with a circular orbit.

  12. Characterization of the atmosphere of the hot Jupiter HAT-P-32Ab and the M-dwarf companion HAT-P-32B

    We report secondary eclipse photometry of the hot Jupiter HAT-P-32Ab, taken with Hale/Wide-field Infra-Red Camera (WIRC) in H and KS bands and with Spitzer/IRAC at 3.6 and 4.5 μm. We carried out adaptive optics imaging of the planet host star HAT-P-32A and its companion HAT-P-32B in the near-IR and the visible. We clearly resolve the two stars from each other and find a separation of 2.''923 ± 0.''004 and a position angle 110.°64 ± 0.°12. We measure the flux ratios of the binary in g'r'i'z' and H and KS bands, and determine T eff= 3565 ± 82 K for the companion star, corresponding to an M1.5 dwarf. We use PHOENIX stellar atmosphere models to correct the dilution of the secondary eclipse depths of the hot Jupiter due to the presence of the M1.5 companion. We also improve the secondary eclipse photometry by accounting for the non-classical, flux-dependent nonlinearity of the WIRC IR detector in the H band. We measure planet-to-star flux ratios of 0.090% ± 0.033%, 0.178% ± 0.057%, 0.364% ± 0.016%, and 0.438% ± 0.020% in the H, KS , 3.6 and 4.5 μm bands, respectively. We compare these with planetary atmospheric models, and find they prefer an atmosphere with a temperature inversion and inefficient heat redistribution. However, we also find that the data are equally well described by a blackbody model for the planet with T p = 2042 ± 50 K. Finally, we measure a secondary eclipse timing offset of 0.3 ± 1.3 minutes from the predicted mid-eclipse time, which constrains e = 0.0072−0.0064+0.0700 when combined with radial velocity data and is more consistent with a circular orbit.

  13. Spin orbit alignment for KELT-7b and HAT-P-56b via Doppler tomography with TRES

    Zhou, George; Bieryla, Allyson; Beatty, Thomas G; Buchhave, Lars A; Esquerdo, Gilbert A; Berlind, Perry; Calkins, Michael L

    2016-01-01

    We present Doppler tomographic analyses for the spectroscopic transits of KELT-7b and HAT-P-56b, two hot-Jupiters orbiting rapidly rotating F-dwarf host stars. These include analyses of archival TRES observations for KELT-7b, and a new TRES transit observation of HAT-P-56b. We report spin-orbit aligned geometries for KELT-7b (2.7 +/- 0.6 deg) and HAT-P-56b (8 +/- 2 deg). The host stars KELT-7 and HAT-P-56 are among some of the most rapidly rotating planet-hosting stars known. We examine the tidal re-alignment model for the evolution of the spin-orbit angle in the context of the spin rates of these stars. We find no evidence that the rotation rates of KELT-7 and HAT-P-56 have been modified by star-planet tidal interactions, suggesting that the spin-orbit angle of systems around these hot stars may represent their primordial configuration. In fact, KELT-7 and HAT-P-56 are two of three systems in super-synchronous, spin-orbit aligned states, where the rotation periods of the host stars are faster than the orbita...

  14. Spin-orbit alignment for KELT-7b and HAT-P-56b via Doppler tomography with TRES

    Zhou, George; Latham, David W.; Bieryla, Allyson; Beatty, Thomas G.; Buchhave, Lars A.; Esquerdo, Gilbert A.; Berlind, Perry; Calkins, Michael L.

    2016-08-01

    We present Doppler tomographic analyses for the spectroscopic transits of KELT-7b and HAT-P-56b, two hot-Jupiters orbiting rapidly rotating F-dwarf host stars. These include analyses of archival Tillinghast Reflector Echelle Spectrograph (TRES) observations for KELT-7b, and a new TRES transit observation of HAT-P-56b. We report spin-orbit aligned geometries for KELT-7b (2.7° ± 0.6°) and HAT-P-56b (8° ± 2°). The host stars KELT-7 and HAT-P-56 are among some of the most rapidly rotating planet-hosting stars known. We examine the tidal re-alignment model for the evolution of the spin-orbit angle in the context of the spin rates of these stars. We find no evidence that the rotation rates of KELT-7 and HAT-P-56 have been modified by star-planet tidal interactions, suggesting that the spin-orbit angle of systems around these hot stars may represent their primordial configuration. In fact, KELT-7 and HAT-P-56 are two of three systems in supersynchronous, spin-orbit aligned states, where the rotation periods of the host stars are faster than the orbital periods of the planets.

  15. Shear wave velocity mapping of Hat Yai district, southern Thailand: implication for seismic site classification

    Soil characteristics play an important role in the degree of ground shaking due to local site amplification during an earthquake. The objectives of this work are to study shear wave velocity (Vs) distribution in the near surface, and to develop a seismic site classification map for soil effect characterization and seismic hazard assessment in Hat Yai district, southern Thailand. The Vs determination based on the multichannel analysis of surface waves technique, has been carried out and analyzed at 70 measuring sites throughout the district. On the basis of the weighted-average Vs in the upper 30 m depth (Vs30), a seismic site classification map, based on the National Earthquake Hazards Reduction Program (NEHRP) standard has been developed. It is found that the NEHRP site class in Hat Yai can be classified into four groups in accordance with the value of Vs30 within the range of about 150 to 1160 m s−1. Most parts of the study area are typically classified as site class C and D. Site class C is mostly found within the colluvial and terrace deposits in the western and eastern part of the area, whereas site class D is concentrated in the alluvial sediment of the middle and northern flood plain areas. A small portion of site class B is observed in the western mountain ranges, where there is a thin overburden on the firm rock. There is a remarkably low Vs30 value at only one site, located near the main stream in the northern part of the study area. The results imply that the soil characteristics in the central and northern Hat Yai district pose a medium to high amplification rate with respect to the other regions. Although Vs data alone are insufficient to verify the potential of the amplification of ground shaking, this study provides an initial attempt to understand seismic hazards in the study area. (paper)

  16. Calculating the Jet Transport Coefficient $\\hat{q}$ in Lattice Gauge Theory

    Majumder, Abhijit

    2012-01-01

    The formalism of jet modification in the higher twist approach is modified to describe a hard parton propagating through a hot thermalized medium. The leading order contribution to the transverse momentum broadening of a high energy (near on-shell) quark in a thermal medium is calculated. This involves a factorization of the perturbative process of scattering of the quark from the non-perturbative transport coefficient. An operator product expansion of the non-perturbative operator product which represents $\\hat{q}$ is carried out and related via dispersion relations to the expectation of local operators. These local operators are then evaluated in quenched SU(2) lattice gauge theory.

  17. Research on the Procedure for Computer-Aided Pattern Design of Uygur's Flowered Hats

    Shuxian Liu; Xiaohua Li

    2013-01-01

    Xinjiang Uygur’s flowered hats is famous all over the world, it leads the world of headwear of variou nationalities within China by the variety of styles, the various ways of how to emroider pattern design and exquisite manufacture. It is unusual even in national costumes art of the world. The poupose of this study is to analyze Uygur's headwear, study the rules of Uygur's headwear pattern, analyze the characteristic of the basic pattern, research on the procedure for computer-aided pattern d...

  18. The TopHat experiment: A balloon-borne instrument for mapping millimeter and submillimeter emission

    Silverberg, R.F.; Cheng, E.S.; Aguirre, J.E.;

    2005-01-01

    The TopHat experiment was designed to measure the anisotropy in the cosmic microwave background radiation on angular scales from 0.degrees 3 to 30 degrees and the thermal emission from both Galactic and extragalactic dust. The balloon-borne instrument had five spectral bands spanning frequencies...... from 175 to 630 GHz. The telescope was a compact, 1 m, on-axis Cassegrain telescope designed to scan the sky at a fixed elevation of 78 degrees. The radiometer used cryogenic bolometers coupled to a single feed horn via a dichroic filter system. The observing strategy was intended to efficiently cover...

  19. Mexican hat curve for hydrogen and antihydrogen-states in natural atom H

    Van Hooydonk, G

    2004-01-01

    Molecular band spectra as well as atomic line spectra reveal a left-right symmetry for atoms (Van Hooydonk, Spectrochim. Acta A, 2000, 56, 2273 and CERN-Ext-2002-041). We now extract a Mexican hat shaped or double well curve from the line spectrum (Lyman ns1/2 singlets) of natural atom H. An H CSB theory and its oscillator contribution (1-0.5pi/n)esp2/nexp2 lead to unprecedented results for antihydrogen physics, ahead of the CERN AD-project on artificial antihydrogen.

  20. HATS-3b: An inflated hot Jupiter transiting an F-type star

    Bayliss, D; Penev, K; Bakos, G; Hartman, J; Jordán, A; Mancini, L; Mohler, M; Suc, V; Rabus, M; Béky, B; Csubry, Z; Buchhave, L; Henning, T; Nikolov, N; Csák, B; Brahm, R; Espinoza, N; Noyes, R; Schmidt, B; Conroy, P; Wright, D; Tinney, C; Addison, B; Sackett, P; Sasselov, D; Lázár, J; Papp, I; Sári, P

    2013-01-01

    We report the discovery by the HATSouth survey of HATS-3b, a transiting extrasolar planet orbiting a V=12.4 F-dwarf star. HATS-3b has a period of P = 3.5479d, mass of Mp = 1.07MJ, and radius of Rp = 1.38RJ. Given the radius of the planet, the brightness of the host star, and the stellar rotational velocity (vsini = 9.0km/s), this system will make an interesting target for future observations to measure the Rossiter-McLaughlin effect and determine its spin-orbit alignment. We detail the low/medium-resolution reconnaissance spectroscopy that we are now using to deal with large numbers of transiting planet candidates produced by the HATSouth survey. We show that this important step in discovering planets produces logg and Teff parameters at a precision suitable for efficient candidate vetting, as well as efficiently identifying stellar mass eclipsing binaries with radial velocity semi-amplitudes as low as 1 km/s.

  1. A Bayesian analysis of HAT-P-7b using the EXONEST algorithm

    Placek, Ben [Department of Physics, University at Albany (SUNY), Albany NY (United States); Knuth, Kevin H. [Department of Physics, University at Albany (SUNY), Albany NY, USA and Department of Informatics, University at Albany (SUNY), Albany NY (United States)

    2015-01-13

    The study of exoplanets (planets orbiting other stars) is revolutionizing the way we view our universe. High-precision photometric data provided by the Kepler Space Telescope (Kepler) enables not only the detection of such planets, but also their characterization. This presents a unique opportunity to apply Bayesian methods to better characterize the multitude of previously confirmed exoplanets. This paper focuses on applying the EXONEST algorithm to characterize the transiting short-period-hot-Jupiter, HAT-P-7b (also referred to as Kepler-2b). EXONEST evaluates a suite of exoplanet photometric models by applying Bayesian Model Selection, which is implemented with the MultiNest algorithm. These models take into account planetary effects, such as reflected light and thermal emissions, as well as the effect of the planetary motion on the host star, such as Doppler beaming, or boosting, of light from the reflex motion of the host star, and photometric variations due to the planet-induced ellipsoidal shape of the host star. By calculating model evidences, one can determine which model best describes the observed data, thus identifying which effects dominate the planetary system. Presented are parameter estimates and model evidences for HAT-P-7b.

  2. The refined physical properties of transiting exoplanetary system WASP-11/HAT-P-10

    The transiting exoplanetary system WASP-11/HAT-P-10 was observed using the CCD camera at Yunnan Observatories, China from 2008 to 2011, and four new transit light curves were obtained. Combined with published radial velocity measurements, the new transit light curves are analyzed along with available photometric data from the literature using the Markov Chain Monte Carlo technique, and the refined physical parameters of the system are derived, which are compatible with the results of two discovery groups, respectively. The planet mass is Mp = 0.526 ± 0.019 MJ , which is the same as West et al.'s value, and more accurately, the planet radius Rp = 0.999−0.018+0.029 RJ is identical to the value of Bakos et al. The new result confirms that the planet orbit is circular. By collecting 19 available mid-transit epochs with higher precision, we make an orbital period analysis for WASP-11b/HAT-P-10b, and derive a new value for its orbital period, P = 3.72247669 days. Through an (O – C) study based on these mid-transit epochs, no obvious transit timing variation signal can be found for this system during 2008-2012.

  3. Structural Performance of a Compressively Loaded Foam-Core Hat-Stiffened Textile Composite Panel

    Ambur, Damodar R.; Dexter, Benson H.

    1996-01-01

    A structurally efficient hat-stiffened panel concept that utilizes a structural foam as a stiffener core material has been designed and developed for aircraft primary structural applications. This stiffener concept is fabricated from textile composite material forms with a resin transfer molding process. This foam-filled hat-stiffener concept is structurally more efficient than most other prismatically stiffened panel configurations in a load range that is typical for both fuselage and wing structures. The panel design is based on woven/stitched and braided graphite-fiber textile preforms, an epoxy resin system, and Rohacell foam core. The structural response of this panel design was evaluated for its buckling and postbuckling behavior with and without low-speed impact damage. The results from single-stiffener and multi-stiffener specimen tests suggest that this structural concept responds to loading as anticipated and has excellent damage tolerance characteristics compared to a similar panel design made from preimpregnated graphite-epoxy tape material.

  4. Transmission spectroscopy of the inflated exo-Saturn HAT-P-19b

    Mallonn, M; Weingrill, J; Strassmeier, K G; Ribas, I; Carroll, T A; Herrero, E; Granzer, T; Claret, A; Schwope, A

    2015-01-01

    We observed the Saturn-mass and Jupiter-sized exoplanet HAT-P-19b to refine its transit parameters and ephemeris as well as to shed first light on its transmission spectrum. We monitored the host star over one year to quantify its flux variability and to correct the transmission spectrum for a slope caused by starspots. A transit of HAT-P-19b was observed spectroscopically with OSIRIS at the Gran Telescopio Canarias in January 2012. The spectra of the target and the comparison star covered the wavelength range from 5600 to 7600 AA. One high-precision differential light curve was created by integrating the entire spectral flux. This white-light curve was used to derive absolute transit parameters. Furthermore, a set of light curves over wavelength was formed by a flux integration in 41 wavelength channels of 50 AA width. We analyzed these spectral light curves for chromatic variations of transit depth. The transit fit of the combined white-light curve yields a refined value of the planet-to-star radius ratio o...

  5. Orbital Phase Variations of the Eccentric Giant Planet HAT-P-2b

    Lewis, Nikole K; Showman, Adam P; Cowan, Nicolas B; Laughlin, Gregory; Burrows, Adam; Deming, Drake; Crepp, Justin R; Mighell, Kenneth J; Agol, Eric; Bakos, Gáspár Á; Charbonneau, David; Désert, Jean-Michel; Fischer, Debra A; Fortney, Jonathan J; Hartman, Joel D; Hinkley, Sasha; Howard, Andrew W; Johnson, John Asher; Kao, Melodie; Langton, Jonathan; Marcy, Geoffrey W; Winn, Joshua N

    2013-01-01

    We present the first secondary eclipse and phase curve observations for the highly eccentric hot Jupiter HAT-P-2b in the 3.6, 4.5, 5.8, and 8.0 \\mu m bands of the Spitzer Space Telescope. The 3.6 and 4.5 \\mu m data sets span an entire orbital period of HAT-P-2b, making them the longest continuous phase curve observations obtained to date and the first full-orbit observations of a planet with an eccentricity exceeding 0.2. We present an improved non-parametric method for removing the intrapixel sensitivity variations in Spitzer data at 3.6 and 4.5 \\mu m that robustly maps position-dependent flux variations. We find that the peak in planetary flux occurs at 4.39+/-0.28, 5.84+/-0.39, and 4.68+/-0.37 hours after periapse passage with corresponding maxima in the planet/star flux ratio of 0.1138%+/-0.0089%, 0.1162%+/-0.0080%, and 0.1888%+/-0.0072% in the 3.6, 4.5, and 8.0 \\mu m bands respectively. We compare our measured secondary eclipse depths to the predictions from a one-dimensional radiative transfer model, wh...

  6. The refined physical properties of transiting exoplanetary system WASP-11/HAT-P-10

    Wang, Xiao-bin; Gu, Sheng-hong; Wang, Yi-bo [Yunnan Observatories, Chinese Academy of Sciences, Kunming 650011 (China); Cameron, Andrew Collier [School of Physics and Astronomy, University of St Andrews, North Haugh, St Andrews, Fife KY16 9SS (United Kingdom); Hui, Ho-Keung; Kwok, Chi-Tai [Hokoon Nature Education Cum Astronomical Centre, Sik Sik Yuen, Hong Kong (China); Yeung, Bill; Leung, Kam-Cheung, E-mail: shenghonggu@ynao.ac.cn [Hong Kong Astronomical Society, Hong Kong (China)

    2014-04-01

    The transiting exoplanetary system WASP-11/HAT-P-10 was observed using the CCD camera at Yunnan Observatories, China from 2008 to 2011, and four new transit light curves were obtained. Combined with published radial velocity measurements, the new transit light curves are analyzed along with available photometric data from the literature using the Markov Chain Monte Carlo technique, and the refined physical parameters of the system are derived, which are compatible with the results of two discovery groups, respectively. The planet mass is M{sub p} = 0.526 ± 0.019 M{sub J} , which is the same as West et al.'s value, and more accurately, the planet radius R{sub p} = 0.999{sub −0.018}{sup +0.029} R{sub J} is identical to the value of Bakos et al. The new result confirms that the planet orbit is circular. By collecting 19 available mid-transit epochs with higher precision, we make an orbital period analysis for WASP-11b/HAT-P-10b, and derive a new value for its orbital period, P = 3.72247669 days. Through an (O – C) study based on these mid-transit epochs, no obvious transit timing variation signal can be found for this system during 2008-2012.

  7. Evidence for Water in the Atmosphere of HAT-P-26b Using LDSS-3C

    Stevenson, Kevin B; Seifahrt, Andreas; Gilbert, Greg; Line, Michael R; Desert, Jean-Michel; Fortney, Jonathan J

    2015-01-01

    The characterization of a physically-diverse set of transiting exoplanets is an important and necessary step towards establishing the physical properties linked to the production of obscuring clouds or hazes. Only planets with identifiable spectroscopic features can effectively enhance our understanding of atmospheric chemistry and metallicity. Using data acquired by the newly-commissioned LDSS-3C instrument on Magellan and the Spitzer Space Telescope, we find evidence for water in the transmission spectrum of the Neptune-mass planet HAT-P-26b. Surprisingly, we detect no trace of potassium. Our measured spectrum is best explained by either a high-metallicity, cloud-free atmosphere or a solar-metallicity atmosphere with a cloud deck at ~10 mbar. The presence of strong spectral features in our data suggests that future observations at higher precision could break this degeneracy and reveal the planet's atmospheric composition. We also update HAT-P-26b's transit ephemeris, t_0 = 2455304.65218(25) BJD_TDB, and or...

  8. Transmission Spectroscopy of HAT-P-32Ab with GTC/OSIRIS

    Nortmann, Lisa; Pallé, Enric; Murgas, Felipe; Dreizler, Stefan; Iro, Nicolas; Cabrera-Lavers, Antonio

    2015-12-01

    I will present one of the latest results of our GTC exoplanet transit spectroscopy survey. Over the last years our group has obtained ground-based optical (538 nm - 918 nm) spectrophotometric transit observations for several hot Jupiters including HAT-P-32Ab using the OSIRIS (Optical System for Imaging and low Resolution Integrated Spectroscopy) instrument at the Spanish 10-meter telescope GTC.I will discuss the source, nature and proper correction of instrument specific systematic noise we found to affect our data. After its correction, we were able to yield high quality results with a precision between 482 and 1703 ppm depending on the wavelength channel. We measure a flat optical transmission spectrum for HAT-P-32Ab, consistent with the results of Gibson et al. (2013, MNRAS, 436, 2974) obtained with GMOS at Gemini-North. This independent reproduction of consistent results re-establishes faith in the reliability of ground-based transmission spectroscopy and emphasizes the high potential of OSIRIS at the GTC as a tool to complement current and future space-based observations.

  9. Refined stellar, orbital and planetary parameters of the eccentric HAT-P-2 planetary system

    Pál, András; Torres, Guillermo; Noyes, Robert W; Fischer, Debra A; Johnson, John A; Henry, Gregory W; Butler, R Paul; Marcy, Geoffrey W; Howard, Andrew W; Sipőcz, Brigitta; Latham, David W; Esquerdo, Gilbert A

    2009-01-01

    We present refined parameters for the HAT-P-2(b) extrasolar planetary system (also known as HD 147506(b)), based on new radial velocity and photometric data. HAT-P-2(b) is a transiting extrasolar planet (TEP) that exhibits an eccentric orbit. We present detailed analysis of the planetary and stellar parameters, yielding consistent results of the mass and radius of the star, better constraints on the orbital eccentricity and refined planetary parameters. Namely, the refined stellar parameters are M_star = 1.36 +/- 0.04 M_sun and R_star = 1.64 +0.09 -0.08 R_sun, while the planet has a mass of M_p = 9.09 +/- 0.24 M_Jup and radius of R_p = 1.157 +0.073 -0.092 R_Jup. The refined ephemeris for the planet are E = 2,454,387.49375 +/- 0.00074 (BJD) and P = 5.6334729 +/- 0.0000061 (days) while the newly obtained orbital eccentricity and argument of pericenter are e = 0.5171 +/- 0.0033 and omega = 185.22 +/- 0.95 degs. These orbital elements allow us to predict the timings of secondary eclipses with a reasonable accurac...

  10. The Transit Light Curve Project. VII. The Not-So-Bloated Exoplanet HAT-P-1b

    Winn, Joshua N; Bakos, Gaspar A; Pal, Andras; Johnson, John Asher; Williams, Peter K G; Shporer, Avi; Mazeh, Tsevi; Fernandez, Jose; Latham, David W

    2007-01-01

    We present photometry of the G0 star HAT-P-1 during six transits of its close-in giant planet, and we refine the estimates of the system parameters. Relative to Jupiter's properties, HAT-P-1b is 1.20 +/- 0.05 times larger and its surface gravity is 2.7 +/- 0.2 times weaker. Although it remains the case that HAT-P-1b is among the least dense of the known sample of transiting exoplanets, its properties are in accord with previously published models of strongly irradiated, coreless, solar-composition giant planets. The times of the transits have a typical accuracy of 1 min and do not depart significantly from a constant period.

  11. Hat die „ökonomische Theorie der Indexzahlen“ einen Nutzen für die Praxis der Preisstatistik?

    von der Lippe, Peter

    2004-01-01

    Die mit dem Thema gestellte Frage wird sehr unterschiedlich beantwortet. Sie ist vielleicht sogar von bleibender Aktualität, selbst dann, wenn sich die anfängliche Begeisterung für den im Folgenden dargestellten „ökonomischen“ oder COLI-Ansatz abgekühlt haben sollte. Die Begeisterung ist vor allem von der sog. „Boskin Kommission“ in den USA geschürt worden und hat, zumindest was das theoretische Leitbild betrifft, auch das BLS erfasst. Es hat jedoch auch stets kritische Stimmen gegeben, und w...

  12. Chaos in classical string dynamics in $\\hat{\\gamma}$ deformed $AdS_5 \\times T^{1,1}$

    Panigrahi, Kamal L

    2016-01-01

    We consider a circular string in $\\hat{\\gamma}$ deformed $AdS_5 \\times T^{1,1}$ which is localized in the center of $AdS_5$ and winds around the two circles of deformed $T^{1,1}$. We observe chaos in the phase space of the circular string implying non-integrability of string dynamics. The chaotic behaviour in phase space is controlled by energy as well as the deforming parameter $\\hat{\\gamma}$. We further show that the point like object exhibits non-chaotic behaviour. Finally we calculate the Lyapunov exponent for both extended and point like object in support of our first result.

  13. TCUP: A Novel hAT Transposon Active in Maize Tissue Culture

    Smith, Alan M; Hansey, Candice N; Kaeppler, Shawn M.

    2012-01-01

    Transposable elements (TEs) are capable of inducing heritable de novo genetic variation. The sequences capable of reactivation, and environmental factors that induce mobilization, remain poorly defined even in well-studied genomes such as maize. We treated maize tissue culture with the demethylating agent 5-aza-2-deoxcytidine and examined long-term tissue culture lines to discover silenced TEs that have the potential to induce heritable genetic variation. Through these screens we have identif...

  14. HAT-P-55b: A Hot Jupiter Transiting a Sun-like Star

    Juncher, D; Hartman, J D; Bakos, G Á; Bieryla, A; Kovács, T; Boisse, I; Latham, D W; Kovács, G; Bhatti, W; Csubry, Z; Penev, K; de Val-Borro, M; Falco, E; Torres, G; Noyes, R W; Lázár, J; Papp, I; Sári, P

    2015-01-01

    We report the discovery of a new transiting extrasolar planet, HAT-P-55b. The planet orbits a V = 13.207 +/- 0.039 sun-like star with a mass of 1.013 +/- 0.037 solar masses, a radius of 1.011 +/- 0.036 solar radii and a metallicity of -0.03 +/- 0.08. The planet itself is a typical hot Jupiter with a period of 3.5852467 +/- 0.0000064 days, a mass of 0.582 +/- 0.056 Jupiter masses and a radius of 1.182 +/- 0.055 Jupiter radii. This discovery adds to the increasing sample of transiting planets with measured bulk densities, which is needed to put constraints on models of planetary structure and formation theories.

  15. Next-to-Leading Order Jet Physics with BlackHat

    Berger, C F; Dixon, L J; Cordero, F Febres; Forde, D; Gleisberg, T; Ita, H; Kosower, D A; Maitre, D

    2009-01-01

    We present several results obtained using the BlackHat next-to-leading order QCD program library, in conjunction with SHERPA. In particular, we present distributions for vector boson plus 1,2,3-jet production at the Tevatron and at the asymptotic running energy of the Large Hadron Collider, including new Z+3-jet distributions. The Z+2-jet predictions for the second-jet P_T distribution are compared to CDF data. We present the jet-emission probability at NLO in W+2-jet events at the LHC, where the tagging jets are taken to be the ones furthest apart in pseudorapidity. We analyze further the large left-handed W polarization, identified in our previous study, for W bosons produced at high P_T at the LHC.

  16. Content Based Image Retrieval Approach Based on Top-Hat Transform And Modified Local Binary Patterns

    Mohammad Saberi

    2012-12-01

    Full Text Available In this paper a robust approach is proposed for content based image retrieval (CBIR using texture analysis techniques. The proposed approach includes three main steps. In the first one, shape detection is done based on Top-Hat transform to detect and crop object part of the image. Second step is included a texture feature representation algorithm using color local binary patterns (CLBP and local variance features. Finally, to retrieve mostly closing matching images to the query, log likelihood ratio is used. The performance of the proposed approach is evaluated using Corel and Simplicity image sets and it compared by some of other well-known approaches in terms of precision and recall which shows the superiority of the proposed approach. Low noise sensitivity, rotation invariant, shift invariant, gray scale invariant and low computational complexity are some of other advantages.

  17. Spherical top-hat collapse of a viscous unified dark fluid

    Li, Wei [Bohai University, Department of Physics, Jinzhou (China); Dalian University of Technology, Institute of Theoretical Physics, Dalian (China); Xu, Lixin [Dalian University of Technology, Institute of Theoretical Physics, Dalian (China)

    2014-05-15

    In this paper, we test the spherical collapse of a viscous unified dark fluid (VUDF) which has constant adiabatic sound speed and show the nonlinear collapse for VUDF, baryons, and darkmatter, which are important in forming the large-scale structure of our Universe. By varying the values of the model parameters α and ζ{sub 0}, we discuss their effects on the nonlinear collapse of the VUDF model, and we compare its result to the ΛCDM model. The results of the analysis show that, within the spherical top-hat collapse framework, larger values of α and smaller values of ζ{sub 0} make the structure formation earlier and faster, and the other collapse curves are almost distinguished with the curve of ΛCDM model if the bulk viscosity coefficient ζ{sub 0} is less than 10{sup -3}. (orig.)

  18. Self-assembled ordered structures in thin films of HAT5 discotic liquid crystal

    Piero Morales

    2010-05-01

    Full Text Available Thin films of the discotic liquid crystal hexapentyloxytriphenylene (HAT5, prepared from solution via casting or spin-coating, were investigated by atomic force microscopy and polarizing optical microscopy, revealing large-scale ordered structures substantially different from those typically observed in standard samples of the same material. Thin and very long fibrils of planar-aligned liquid crystal were found, possibly formed as a result of an intermediate lyotropic nematic state arising during the solvent evaporation process. Moreover, in sufficiently thin films the crystallization seems to be suppressed, extending the uniform order of the liquid crystal phase down to room temperature. This should be compared to the bulk situation, where the same material crystallizes into a polymorphic structure at 68 °C.

  19. High-harmonic and terahertz wave spectroscopy (HATS) for aligned molecules

    Huang, Yindong; Zhao, Jing; Wang, Xiaowei; Lü, Zhihui; Zhang, Dongwen; Yuan, Jianmin; Zhao, Zengxiu

    2016-01-01

    We present the experimental and theoretical details of our recent published letter [Phys. Rev. Lett. 115. 123002] on synchronized high-harmonic and terahertz-wave spectroscopy (HATS) from nonadiabatically aligned nitrogen molecules in dual-color laser fields. Associating the alignment-angle dependent terahertz wave generation with the synchronizing high-harmonic signal, the angular differential photoionization cross section (PICS) for molecules can be reconstructed, and the minima of the angle on PICS show great convergence between the theoretical predictions and the experimental deduced results. We also show the optimal relative phase between the dual-color laser fields for terahertz wave generation dose not change with the alignment angle at a precision of $50$ attoseconds. This all-optical method provides an alternative for investigating molecular structures and dynamics.

  20. 3D spin-orbit angle of Kepler-25 and HAT-P-7

    Benomar Othman

    2015-01-01

    Full Text Available The number of discovered exoplanets now exceeds 1500, mostly due to the Kepler space instrument observations. Many of these planet orbit in less than a week around their host stars. This implies that the inward migration of those planets is a basic ingredient of successful theories of planet formation and evolution. Several mechanisms have been proposed to explain the observed periods, which lead to different orbit eccentricity and obliquity distributions. Here we summarise and discuss the results of obliquities for two Kepler stars: HAT-P-7 and Kepler-25. These are interesting stellar systems as we could carry out a joint analysis using asteroseismology, transit lightcurve and the Rossiter-McLaughlin effect in order to measure the three dimensional obliquity.

  1. Viscous Chaplygin gas models as spherical top-hat collapsing fluids

    Jawad, Abdul; Iqbal, Ayesha

    2016-05-01

    We study the spherical top-hat collapse in Einstein gravity and loop quantum cosmology (LQC) by taking the nonlinear evolution of viscous modified variable Chaplygin gas (CG) and viscous generalized cosmic chaplygin gas (GCCG). We calculate the equation of state (EoS) parameter, square speed of sound, perturbed (EoS) parameter, perturbed square speed of sound, density contrast and divergence of peculiar velocity in perturbed region and discussed their behavior. It is observed that both CG models support the spherical collapse (SC) in Einstein as well as LQC because density contrast remains positive in both cases and the perturbed EoS parameter remains positive at the present epoch as well as near future. It is remarked here that these parameters provide consistent results for both CG models in both gravities.

  2. Pharmacogenetic effects of 'candidate gene complexes' on stroke in the GenHAT study

    Sørensen, Izel F; Vazquez, Ana I; Irvin, Marguerite R;

    2014-01-01

    Americans and 539 whites who had experienced stroke in the GenHAT study were genotyped for 768 single nucleotide polymorphisms (SNPs) in 280 candidate genes. To detect a genotype-by-treatment interaction, we used the Pearson's χ-test to assess whether the genotype frequencies differed at the single SNP...... level for the three drug treatment groups. From these single SNP analyses, we derived a summary statistic for the degree of association at the gene and gene complex levels. This was done by grouping SNPs using information on gene locations and defining gene complexes on the basis of protein...... groups. In African Americans, SNP rs12143842 showed a significant association (P<0.001) with drug treatment. At the gene level, HNRNPA1P4 and NOS1AP in African Americans and PRICKLE1 and NINJ2 in non-Hispanic whites were significantly associated (P<0.01) with drug treatment, whereas none of the gene...

  3. Logarithmic sℓ-hat (2) CFT models from Nichols algebras: I

    We construct chiral algebras that centralize rank-2 Nichols algebras with at least one fermionic generator. This gives ‘logarithmic’ W-algebra extensions of a fractional-level sℓ-hat (2) algebra. We discuss crucial aspects of the emerging general relation between Nichols algebras and logarithmic conformal field theory (CFT) models: (i) the extra input, beyond the Nichols algebra proper, needed to uniquely specify a conformal model; (ii) a relation between the CFT counterparts of Nichols algebras connected by Weyl groupoid maps; and (iii) the common double bosonization U(X) of such Nichols algebras. For an extended chiral algebra, candidates for its simple modules that are counterparts of the U(X) simple modules are proposed, as a first step toward a functorial relation between U(X) and W-algebra representation categories. (paper)

  4. Using Edward de Bono's six hats game to aid critical thinking and reflection in palliative care.

    Kenny, Lesley J

    2003-03-01

    This article describes the use of a creative thinking game to stimulate critical thinking and reflection with qualified health professionals undertaking palliative care education. The importance of reflective practice in nursing is well documented and numerous models are available. However, the author as a nurse teacher has found that many of these models are either too simple or too complex to be valuable in practice. The six hats game, devised by Edward de Bono, is a method that stimulates a variety of types of thinking and when used as a means of reflection helps students to become more critical about their practice. Using this game with a palliative care case study the author demonstrates how thinking more creatively about the patients' perceived needs and problems can assist in developing reflective skills. The article concludes with a discussion on some of the challenges of using this method and suggestions for future practical uses. PMID:12682572

  5. A 82Br tracer study of coastal groundwater movement at Hat Head, NSW

    At Hat Head, NSW, on the eastern Australian coast, a radioisotope tracer study of groundwater flow in response to tidal forcing was conducted adjacent to a tidal creek. Using radiotracer, 82Br, groundwater movement was tracked in-situ over 5 days on two occasions encompassing both neap and spring tide conditions. The tracer was injected into one borehole and gamma counts monitored from an adjacent borehole using NaI(Th) detectors. This technique maps the path of the slow moving tracer without sampling and allows the net groundwater movement to be distinguished from short term tidally driven fluxes. During the neap tide period net groundwater movement of 0.1 m/d was observed with horizontal tidal fluctuations in the order of 0.04 m. This contrasts with the tidally dominated spring tide period where net groundwater movement was negligible but tidally driven fluctuations of up to 0.13 m were observed

  6. Wave turbulence description of interacting particles: Klein-Gordon model with a Mexican-hat potential

    Gallet, Basile; Dubrulle, Bérengère

    2015-01-01

    In field theory, particles are waves or excitations that propagate on the fundamental state. In experiments or cosmological models one typically wants to compute the out-of-equilibrium evolution of a given initial distribution of such waves. Wave Turbulence deals with out-of-equilibrium ensembles of weakly nonlinear waves, and is therefore well-suited to address this problem. As an example, we consider the complex Klein-Gordon equation with a Mexican-hat potential. This simple equation displays two kinds of excitations around the fundamental state: massive particles and massless Goldstone bosons. The former are waves with a nonzero frequency for vanishing wavenumber, whereas the latter obey an acoustic dispersion relation. Using wave turbulence theory, we derive wave kinetic equations that govern the coupled evolution of the spectra of massive and massless waves. We first consider the thermodynamic solutions to these equations and study the wave condensation transition, which is the classical equivalent of Bo...

  7. SPITZER IRAC SECONDARY ECLIPSE PHOTOMETRY OF THE TRANSITING EXTRASOLAR PLANET HAT-P-1b

    We report Spitzer/IRAC photometry of the transiting giant exoplanet HAT-P-1b during its secondary eclipse. This planet lies near the postulated boundary between the pM and pL-class of hot Jupiters, and is important as a test of models for temperature inversions in hot Jupiter atmospheres. We derive eclipse depths for HAT-P-1b, in units of the stellar flux, that are: 0.080% ± 0.008% [3.6 μm], 0.135% ± 0.022% [4.5 μm], 0.203% ± 0.031% [5.8 μm], and 0.238% ± 0.040% [8.0 μm]. These values are best fit using an atmosphere with a modest temperature inversion, intermediate between the archetype inverted atmosphere (HD 209458b) and a model without an inversion. The observations also suggest that this planet is radiating a large fraction of the available stellar irradiance on its dayside, with little available for redistribution by circulation. This planet has sometimes been speculated to be inflated by tidal dissipation, based on its large radius in discovery observations, and on a non-zero orbital eccentricity allowed by the radial velocity data. The timing of the secondary eclipse is very sensitive to orbital eccentricity, and we find that the central phase of the eclipse is 0.4999 ± 0.0005. The difference between the expected and observed phase indicates that the orbit is close to circular, with a 3σ limit of |e cos ω| < 0.002.

  8. Inhibition of Different Histone Acetyltransferases (HATs) Uncovers Transcription-Dependent and -Independent Acetylation-Mediated Mechanisms in Memory Formation

    Merschbaecher, Katja; Hatko, Lucyna; Folz, Jennifer; Mueller, Uli

    2016-01-01

    Acetylation of histones changes the efficiency of the transcription processes and thus contributes to the formation of long-term memory (LTM). In our comparative study, we used two inhibitors to characterize the contribution of different histone acetyl transferases (HATs) to appetitive associative learning in the honeybee. For one we applied…

  9. Development of a helmet/helmet-display-unit alignment tool (HAT) for the Apache helmet and display unit

    McLean, William; Statz, Jonathan; Estes, Victor; Booms, Shawn; Martin, John S.; Harding, Thomas

    2015-05-01

    Project Manager (PM) Apache Block III contacted the U.S. Army Aeromedical Research Laboratory (USAARL), Fort Rucker, Alabama, requesting assistance to evaluate and find solutions to a government-developed Helmet Display Unit (HDU) device called the Mock HDU for helmet alignment of the Apache Advanced Integrated Helmet (AAIH). The AAIH is a modified Head Gear Unit No. 56 for Personnel (HGU-56/P) to replace the current Integrated Helmet and Sighting System (IHADSS). The current flashlight-based HDU simulator for helmet/HDU alignment was no longer in production or available. Proper helmet/HDU alignment is critical to position the right eye in the small HDU eye box to obtain image alignment and full field of view (FOV). The initial approach of the PM to developing a helmet/HDU fitting device (Mock HDU) was to duplicate the optical characteristics of the current tactical HDU using less complex optics. However, the results produced questionable alignment, FOV, and distortion issues, with cost and development time overruns. After evaluating the Mock HDU, USAARL proposed a cost effective, less complex optical design called the Helmet/HDU Alignment Tool (HAT). This paper will show the development, components, and evaluations of the HAT compared to the current flashlight HDU simulator device. The laboratory evaluations included FOV measurements and alignment accuracies compared to tactical HDUs. The Apache helmet fitter technicians and Apache pilots compared the HAT to the current flashlight based HDU and ranked the HAT superior.

  10. BALTIMORE’S M.S. LEVY AND SONS: Straw Hat Makers to the World, 1870-1960

    Jessica I. Elfenbein

    2008-01-01

    Full Text Available From 1860 to 1960, Baltimore was an important center of the men’s ready-to- wear clothing industries. German-speaking Jews created many businesses that manufactured and sold underwear, men’s suits, and specialty items like hats and umbrellas. The straw hat making firm started by M.S. Levy is an interesting example of a Baltimore-based, family-owned niche business that existedfor 90 years, through three generations ofa singlefamily. The M.S. Levy and Sons story has two main chapters. The first covers the period from its founding by Michael Simon Levy in the 1870s through his son Julius’ death in 1926. This is the story of ascension. A premonition about the coming popularity of straw hats, together with a small but important technological breakthrough, positioned a family and a small industry for significant expansion. The second period began in 1930 with the introduction of wool felt hats and the death of William, M.S. Levy’s oldest son, and includes the Great Depression, unionization, merger, third generation leadership, and finally, in 1959, the family’s withdrawal from the industry. This later period, as told by grandsons of the founder, is the story of struggle followed by decline.

  11. The Candida albicans Histone Acetyltransferase Hat1 Regulates Stress Resistance and Virulence via Distinct Chromatin Assembly Pathways.

    Michael Tscherner

    2015-10-01

    Full Text Available Human fungal pathogens like Candida albicans respond to host immune surveillance by rapidly adapting their transcriptional programs. Chromatin assembly factors are involved in the regulation of stress genes by modulating the histone density at these loci. Here, we report a novel role for the chromatin assembly-associated histone acetyltransferase complex NuB4 in regulating oxidative stress resistance, antifungal drug tolerance and virulence in C. albicans. Strikingly, depletion of the NuB4 catalytic subunit, the histone acetyltransferase Hat1, markedly increases resistance to oxidative stress and tolerance to azole antifungals. Hydrogen peroxide resistance in cells lacking Hat1 results from higher induction rates of oxidative stress gene expression, accompanied by reduced histone density as well as subsequent increased RNA polymerase recruitment. Furthermore, hat1Δ/Δ cells, despite showing growth defects in vitro, display reduced susceptibility to reactive oxygen-mediated killing by innate immune cells. Thus, clearance from infected mice is delayed although cells lacking Hat1 are severely compromised in killing the host. Interestingly, increased oxidative stress resistance and azole tolerance are phenocopied by the loss of histone chaperone complexes CAF-1 and HIR, respectively, suggesting a central role for NuB4 in the delivery of histones destined for chromatin assembly via distinct pathways. Remarkably, the oxidative stress phenotype of hat1Δ/Δ cells is a species-specific trait only found in C. albicans and members of the CTG clade. The reduced azole susceptibility appears to be conserved in a wider range of fungi. Thus, our work demonstrates how highly conserved chromatin assembly pathways can acquire new functions in pathogenic fungi during coevolution with the host.

  12. HAT-P-13b,c: A TRANSITING HOT JUPITER WITH A MASSIVE OUTER COMPANION ON AN ECCENTRIC ORBIT

    We report on the discovery of a planetary system with a close-in transiting hot Jupiter on a near circular orbit and a massive outer planet on a highly eccentric orbit. The inner planet, HAT-P-13b, transits the bright V = 10.622 G4 dwarf star GSC 3416 - 00543 every P = 2.916260 ± 0.000010 days, with transit epoch Tc = 2454779.92979 ± 0.00038 (BJD) and duration 0.1345 ± 0.0017 days. The outer planet HAT-P-13c orbits the star every P 2 = 428.5 ± 3.0 days with a nominal transit center (assuming zero impact parameter) of T 2c = 2454870.4 ± 1.8 (BJD) or time of periastron passage T 2,peri = 2454890.05 ± 0.48 (BJD). Transits of the outer planet have not been observed, and may not be present. The host star has a mass of 1.22+0.05-0.10 M sun, radius of 1.56 ± 0.08 R sun, effective temperature of 5653 ± 90 K, and is rather metal-rich with [Fe/H] = +0.41 ± 0.08. The inner planetary companion has a mass of 0.853+0.029-0.046 M J, and radius of 1.281 ± 0.079 R J, yielding a mean density of 0.498+0.103-0.069 g cm-3. The outer companion has m 2sin i 2 = 15.2 ± 1.0 M J, and orbits on a highly eccentric orbit of e 2 = 0.691 ± 0.018. While we have not detected significant transit timing variations of HAT-P-13b, due to gravitational and light-travel time effects, future observations will constrain the orbital inclination of HAT-P-13c, along with its mutual inclination to HAT-P-13b. The HAT-P-13 (b, c) double-planet system may prove extremely valuable for theoretical studies of the formation and dynamics of planetary systems.

  13. Structure of the Hat Creek graben region: Implications for the structure of the Hat Creek graben and transfer of right-lateral shear from the Walker Lane north of Lassen Peak, northern California, from gravity and magnetic anomalies

    Langenheim, Victoria; Jachens, Robert C.; Clynne, Michael A.; Muffler, L. J. Patrick

    2016-01-01

    Interpretation of magnetic and new gravity data provides constraints on the geometry of the Hat Creek Fault, the amount of right-lateral offset in the area between Mt. Shasta and Lassen Peak, and confirmation of the influence of pre-existing structure on Quaternary faulting. Neogene volcanic rocks coincide with short-wavelength magnetic anomalies of both normal and reversed polarity, whereas a markedly smoother magnetic field occurs over the Klamath Mountains and its Paleogene cover. Although the magnetic field over the Neogene volcanic rocks is complex, the Hat Creek Fault, which is one of the most prominent normal faults in the region and forms the eastern margin of the Hat Creek Valley, is marked by the eastern edge of a north-trending magnetic and gravity high 20-30 km long. Modeling of these anomalies indicates that the fault is a steeply dipping (~75-85°) structure. The spatial relationship of the fault as modeled by the potential-field data, the youngest strand of the fault, and relocated seismicity suggests that deformation continues to step westward across the valley, consistent with a component of right-lateral slip in an extensional environment. Filtered aeromagnetic data highlight a concealed magnetic body of Mesozoic or older age north of Hat Creek Valley. The body’s northwest margin strikes northeast and is linear over a distance of ~40 km. Within the resolution of the aeromagnetic data (1-2 km), we discern no right-lateral offset of this body. Furthermore, Quaternary faults change strike or appear to end, as if to avoid this concealed magnetic body and to pass along its southeast edge, suggesting that pre-existing crustal structure influenced younger faulting, as previously proposed based on gravity data.

  14. Further constraints on the optical transmission spectrum of HAT-P-1b

    Montalto, M; Santos, N C; Desidera, S; Martins, J H C; Figueira, P; Alonso, R; .,

    2015-01-01

    We report on novel observations of HAT-P-1 aimed at constraining the optical transmission spectrum of the atmosphere of its transiting Hot-Jupiter exoplanet. Ground-based differential spectrophotometry was performed over two transit windows using the DOLORES spectrograph at the Telescopio Nazionale Galileo (TNG). Our measurements imply an average planet to star radius ratio equal to $\\rm R_p/R_{\\star}$=(0.1159$\\pm$0.0005). This result is consistent with the value obtained from recent near infrared measurements of this object but differs from previously reported optical measurements being lower by around 4.4 exoplanet scale heights. Analyzing the data over 5 different spectral bins 600\\AA$\\,$ wide we observed a single peaked spectrum (3.7 $\\rm\\sigma$ level) with a blue cut-off corresponding to the blue edge of the broad absorption wing of sodium and an increased absorption in the region in between 6180-7400\\AA. We also infer that the width of the broad absorption wings due to alkali metals is likely narrower t...

  15. Sampling of BTX in Hat Yai city using cost effective laboratory-built PCB passive sampler.

    Subba, Jas Raj; Thammakhet, Chongdee; Thavarungkul, Panote; Kanatharana, Proespichaya

    2016-08-23

    A laboratory-built printed circuit board (PCB) passive sampler used for the monitoring of xylene and styrene in copy print shops was re-validated for detecting benzene, toluene and xylene (BTX) and applied for the sampling of ambient air from Hat Yai city, Songkhla, Thailand, in the month of November 2014. For monitoring, the PCB passive samplers were exposed to target analytes in 16 locations covering high to low exposure areas. After sampling, the samplers were thermally desorbed and the analytes were trapped by multi-walled carbon nanotubes packed into a micro-preconcentrator coupled to a gas chromatograph (GC) equipped with a flame ionization detector. At the optimum GC operating conditions, the linear dynamic ranges for BTX were 0.06-5.6 µg for benzene, 0.07-2.2 µg for toluene and 0.23-2.5 µg for xylene with R(2) > 0.99 with the limits of detection being 6.6, 6.8 and 19 ng for benzene, toluene and xylene, respectively. The concentrations of BTX in the 16 sampling sites were in the range of N.D.-1.3 ± 1.6, 4.50 ± 0.76-49.6 ± 3.7 and 1.00 ± 0.21-39.6 ± 3.1 µg m(-3), respectively. When compared to past studies, there had been an increase in the benzene concentration. PMID:27231039

  16. Confrontation of top-hat spherical collapse against dark halos from cosmological N-body simulations

    Suto, Daichi; Kitayama, Tetsu; Osato, Ken; Sasaki, Shin; Suto, Yasushi

    2016-02-01

    The top-hat spherical collapse model (TSC) is one of the most fundamental analytical frameworks to describe the non-linear growth of cosmic structure. TSC has motivated, and been widely applied in, various investigations even in the current era of precision cosmology. While numerous studies exist to examine its validity against numerical simulations in a statistical fashion, there are few analyses which compare the TSC dynamics in an individual object-wise basis, which is what we attempt in the present paper. We extract 100 halos at z = 0 from a cosmological N-body simulation according to the conventional TSC criterion for the spherical over-density. Then we trace back their spherical counterparts at earlier epochs. Just prior to the turn-around epoch of the halos, their dynamics are well approximated by TSC, but their turn-around epochs are systematically delayed and the virial radii are larger by ˜20% on average relative to the TSC predictions. We find that this systematic deviation can mainly be ascribed to the non-uniformity/inhomogeneity of dark matter density profiles and the non-zero velocity dispersions, both of which are neglected in TSC. In particular, the inside-out collapse and shell-crossing of dark matter halos play an important role in generating the significant velocity dispersion. The implications of the present result are briefly discussed.

  17. Confrontation of Top-Hat Spherical Collapse against Dark Halos from Cosmological N-Body Simulations

    Suto, Daichi; Osato, Ken; Sasaki, Shin; Suto, Yasushi

    2015-01-01

    The top-hat spherical collapse model (TSC) is one of the most fundamental analytical frameworks to describe the non-linear growth of cosmic structure. TSC has motivated, and been widely applied in, various researches even in the current era of precision cosmology. While numerous studies exist to examine its validity against numerical simulations in a statistical fashion, there are few analyses to compare the TSC dynamics in an individual object-wise basis, which is what we attempt in the present paper. We extract 100 halos at z = 0 from a cosmological N-body simulation according to the conventional TSC criterion for the spherical over-density. Then we trace back their spherical counter-parts at earlier epochs. Just prior to the turn-around epoch of the halos, their dynamics is well approximated by TSC, but their turn-around epochs are systematically delayed and the virial radii are larger by ~ 20 percent on average relative to the TSC predictions. We find that this systematic deviation is mainly ascribed to t...

  18. Bayesian estimation inherent in a Mexican-hat-type neural network

    Takiyama, Ken

    2016-05-01

    Brain functions, such as perception, motor control and learning, and decision making, have been explained based on a Bayesian framework, i.e., to decrease the effects of noise inherent in the human nervous system or external environment, our brain integrates sensory and a priori information in a Bayesian optimal manner. However, it remains unclear how Bayesian computations are implemented in the brain. Herein, I address this issue by analyzing a Mexican-hat-type neural network, which was used as a model of the visual cortex, motor cortex, and prefrontal cortex. I analytically demonstrate that the dynamics of an order parameter in the model corresponds exactly to a variational inference of a linear Gaussian state-space model, a Bayesian estimation, when the strength of recurrent synaptic connectivity is appropriately stronger than that of an external stimulus, a plausible condition in the brain. This exact correspondence can reveal the relationship between the parameters in the Bayesian estimation and those in the neural network, providing insight for understanding brain functions.

  19. HAT-P-55b: A Hot Jupiter Transiting a Sun-Like Star

    Juncher, D.; Buchhave, L. A.; Hartman, J. D.; Bakos, G. Á.; Bieryla, A.; Kovács, T.; Boisse, I.; Latham, D. W.; Kovács, G.; Bhatti, W.; Csubry, Z.; Penev, K.; de Val-Borro, M.; Falco, E.; Torres, G.; Noyes, R. W.; Lázár, J.; Papp, I.; Sári, P.

    2015-09-01

    We report the discovery of a new transiting extrasolar planet, HAT-P-55b . The planet orbits a V = 13.207 ± 0.039 sun-like star with a mass of 1.013 ± 0.037 Msolar, a radius of 1.011 ± 0.036 Rsolar, and a metallicity of -0.03 ± 0.08. The planet itself is a typical hot Jupiter with a period of 3.5852467 ± 0.0000064 days, a mass of 0.582 ± 0.056 MJ and a radius of 1.182 ± 0.055 RJ. This discovery adds to the increasing sample of transiting planets with measured bulk densities, which is needed to put constraints on models of planetary structure and formation theories. Based on observations obtained with the Hungarian-made Automated Telescope Network. Based in part on radial velocities obtained with the SOPHIE spectrograph mounted on the 1.93-m telescope at Observatoire de Haute-Provence, France. Based in part on observations made with the Nordic Optical Telescope, operated on the island of La Palma jointly by Denmark, Finland, Iceland, Norway, and Sweden, in the Spanish Observatorio del Roque de los Muchachos of the Instituto de Astrofísica de Canarias. Based in part on observations obtained with the Tillinghast Reflector 1.5-m telescope and the 1.2-m telescope, both operated by the Smithsonian Astrophysical Observatory at the Fred Lawrence Whipple Observatory in Arizona.

  20. Intensity and Pattern of Land Surface Temperature in Hat Yai City, Thailand

    Poonyanuch RUTHIRAKO

    2014-07-01

    Full Text Available Land Surface Temperature (LST is an important factor in global climate. LST is governed by surface heat fluxes, which are affected by urbanization. In order to understand urban climate, LST needs to be examined. This study aimed to investigate the intensity and pattern of LST and examine the relationships between LST and the characteristics of urban land use, indices, and population density in Hat Yai City. Landsat 5TM images were used for interpretation of land use characteristics and derivation of LST, normalized difference built-up index (NDBI and normalized vegetation index (NDVI. The characteristics of land use were classified into 4 types: commercial/high density residential, medium density residential, minimum density residential and vegetation cover/park. The average maximum and minimum LST derived from Landsat 5TM were 25.9, 33.7 and 15.8 °C, respectively. The areas with high LST were located principally in central built-up areas, slightly northwest-southeast of the study area, including the commercial center and the newly expanded residential areas. The LST pattern was well related to land use types and population density. The relationship between LST and NDVI however portrayed negative correlation, while that between LST and NDBI highlighted a positive correlation. It is concluded that NDVI and NDBI can be used to evaluate the risk of Urban Heat Island (UHI and may help city managers better prepare for possible impacts of climate change.

  1. Improved hole-transporting property via HAT-CN for perovskite solar cells without lithium salts.

    Ma, Yingzhuang; Chung, Yao-Hsien; Zheng, Lingling; Zhang, Danfei; Yu, Xiao; Xiao, Lixin; Chen, Zhijian; Wang, Shufeng; Qu, Bo; Gong, Qihuang; Zou, Dechun

    2015-04-01

    A nonadditive hole-transporting material (HTM) of a triphenylamine derivative of N,N'-di(3-methylphenyl)-N,N'-diphenyl-4,4'-diaminobiphenyl (TPD) is used for the organic-inorganic hybrid perovskite solar cells. The power conversion efficiency (PCE) can be significantly enhanced by inserting a thin layer of 1,4,5,8,9,11-hexaazatriphenylenehexacarbonitrile (HAT-CN) without adding an ion additive because the hole-transporting properties improve. The short-circuit current density (J(sc)) increases from 8.5 to 13.1 mA/cm(2), the open-circuit voltage (V(oc)) increases from 0.84 to 0.92 V, and the fill-factor (FF) increases from 0.45 to 0.59, which corresponds to the increase in PCE from 3.2% to 7.1%. Moreover, the PCE decreases by only 10% after approximately 1000 h without encapsulation, which suggests an alternative method to improve the stability of perovskite solar cells. PMID:25761404

  2. Detection of DNA Hypomethylation Mediated Floral Induction in Longan and Spinach Using the HAT-RAPD Technique

    S. Anuntalabhochai

    2009-01-01

    Full Text Available In this study, the HAT-RAPD technique was used to detect DNA methylation in the four plant species, rice (Oryza sativa, petunia (Petunia hybrida, spinach (Spinacea oleracea L. and longan (Dimocarpus longan Lour., which were treated using 5-azacytidine, potassium chlorate (KClO3 and a low temperature induction. Rice and petunia were chosen to be induced because in these species it is known that 5-azacytidine is able to induce hypomethylation in their genomes leading to morphological changes, in particular floral induction, in the developing plants. Using the HAT-RAPD technique, DNA methylation was detected using the restriction enzymes HpaII and MspI in rice and petunia (as expected and in spinach, but was found to be absent in longan, which suggests that floral induction in longan is undetectable in longan.

  3. Broad-band spectrophotometry of HAT-P-32 b: Search for a scattering signature in the planetary spectrum

    Mallonn, M; Herrero, E; Hoyer, S; Kirk, J; Wheatley, P J; Seeliger, M; Mackebrandt, F; von Essen, C; Strassmeier, K G; Granzer, T; Künstler, A; Dhillon, V S; Marsh, T R; Gaitan, J

    2016-01-01

    Multi-colour broad-band transit observations offer the opportunity to characterise the atmosphere of an extrasolar planet with small- to medium-sized telescopes. One of the most favourable targets is the hot Jupiter HAT-P-32 b. We combined 21 new transit observations of this planet with 36 previously published light curves for a homogeneous analysis of the broad-band transmission spectrum from the Sloan u' band to the Sloan z' band. Our results rule out cloud-free planetary atmosphere models of solar metallicity. Furthermore, a discrepancy at reddest wavelengths to previously published results makes a recent tentative detection of a scattering feature less likely. Instead, the available spectral measurements of HAT-P-32 b favour a completely flat spectrum from the near-UV to the near-IR. A plausible interpretation is a thick cloud cover at high altitudes.

  4. Students; Perceptions About Using six Thinking hats And Attribute Listing Techniques ın the Science Course

    Koray, Yrd. Doç. Dr. Özlem

    2005-01-01

    The purpose of the study was to detect opinions of the students about the implementation of six thinking hats and attribute listing techniques related in practice science course. Data were collected via an interview form and open-ended questions constructed by researcher. The results of the study revealed that the primary school students (6th, 7thand 8th grade) and pre-service science teachers had positive perceptions about these techniques. Summary Continuous changes and developments m...

  5. Bound state energy of a Coulomb impurity in gapped bilayer graphene: "Hydrogen atom with a Mexican hat"

    Skinner, Brian; Shklovskii, B. I.; Voloshin, M. B.

    2013-01-01

    Application of a perpendicular electric field induces a band gap in bilayer graphene, and it also creates a "Mexican hat" structure in the dispersion relation. This structure has unusual implications for the hydrogen-like bound state of an electron to a Coulomb impurity. We calculate the ground state energy of this hydrogen-like state as a function of the applied interlayer voltage and the effective fine structure constant. Unlike in the normal hydrogen atom, the resulting wavefunction has ma...

  6. Standard Model evaluation of $\\varepsilon_K$ using lattice QCD inputs for $\\hat{B}_K$ and $V_{cb}$

    Bailey, Jon A; Lee, Weonjong; Park, Sungwoo

    2015-01-01

    We report the Standard Model evaluation of the indirect CP violation parameter $\\varepsilon_K$ using inputs from lattice QCD: the kaon bag parameter $\\hat{B}_K$, $\\xi_0$, $|V_{us}|$ from the $K_{\\ell 3}$ and $K_{\\mu 2}$ decays, and $|V_{cb}|$ from the axial current form factor for the exclusive decay $\\bar{B} \\to D^* \\ell \\bar{\

  7. Energy versus centrality dependence of the jet quenching parameter $\\hat q$ at RHIC and LHC: a new puzzle?

    Andrés, Carlota; Luzum, Matthew; Salgado, Carlos A; Zurita, Pía

    2016-01-01

    The central goal of jet quenching studies in high-energy nuclear collisions is the characterization of those QCD medium properties that are accessible by these probes. Most of the discussion in the last years has been focused on the determination of the jet quenching parameter, $\\hat q$. We present here an extraction of this parameter using data of inclusive particle suppression at RHIC and LHC energies for different centralities. Our approach consists of fitting a $K$ factor that quantifies the departure of this parameter from an ideal estimate, $K\\equiv \\hat q/(2\\epsilon^{3/4})$, where $\\hat q$ is determined by the local medium quantities as provided by hydrodynamical calculations. We find that this $K$ factor is larger at RHIC than at the LHC, as obtained already in previous analyses, but, surprisingly, it is almost independent of the centrality of the collision. Taken at face value, the $K$ factor would not depend on the local properties of the medium as energy density or temperature, but on global collis...

  8. Fluctuations of hi-hat timing and dynamics in a virtuoso drum track of a popular music recording.

    Esa Räsänen

    Full Text Available Long-range correlated temporal fluctuations in the beats of musical rhythms are an inevitable consequence of human action. According to recent studies, such fluctuations also lead to a favored listening experience. The scaling laws of amplitude variations in rhythms, however, are widely unknown. Here we use highly sensitive onset detection and time series analysis to study the amplitude and temporal fluctuations of Jeff Porcaro's one-handed hi-hat pattern in "I Keep Forgettin'"-one of the most renowned 16th note patterns in modern drumming. We show that fluctuations of hi-hat amplitudes and interbeat intervals (times between hits have clear long-range correlations and short-range anticorrelations separated by a characteristic time scale. In addition, we detect subtle features in Porcaro's drumming such as small drifts in the 16th note pulse and non-trivial periodic two-bar patterns in both hi-hat amplitudes and intervals. Through this investigation we introduce a step towards statistical studies of the 20th and 21st century music recordings in the framework of complex systems. Our analysis has direct applications to the development of drum machines and to drumming pedagogy.

  9. Fluctuations of hi-hat timing and dynamics in a virtuoso drum track of a popular music recording.

    Räsänen, Esa; Pulkkinen, Otto; Virtanen, Tuomas; Zollner, Manfred; Hennig, Holger

    2015-01-01

    Long-range correlated temporal fluctuations in the beats of musical rhythms are an inevitable consequence of human action. According to recent studies, such fluctuations also lead to a favored listening experience. The scaling laws of amplitude variations in rhythms, however, are widely unknown. Here we use highly sensitive onset detection and time series analysis to study the amplitude and temporal fluctuations of Jeff Porcaro's one-handed hi-hat pattern in "I Keep Forgettin'"-one of the most renowned 16th note patterns in modern drumming. We show that fluctuations of hi-hat amplitudes and interbeat intervals (times between hits) have clear long-range correlations and short-range anticorrelations separated by a characteristic time scale. In addition, we detect subtle features in Porcaro's drumming such as small drifts in the 16th note pulse and non-trivial periodic two-bar patterns in both hi-hat amplitudes and intervals. Through this investigation we introduce a step towards statistical studies of the 20th and 21st century music recordings in the framework of complex systems. Our analysis has direct applications to the development of drum machines and to drumming pedagogy. PMID:26039256

  10. Widefield imaging of upconverting nanoparticles on epifluorescence microscopes adapted for laser illumination with top-hat profile

    Mrazek, Jiri; Pospisilova, Martina; Svozil, Vit; Cadek, Ondrej; Nesporova, Kristina; Sulakova, Romana; Brandejsova, Martina; Vranova, Jana; Velebny, Vladimir

    2016-05-01

    We describe a modification of epifluorescence microscopes that allows quantitative widefield imaging of samples labeled by upconverting nanoparticles (UCNP). A top-hat illumination profile on the sample was achieved with a 980-nm laser diode by using tandem microlens arrays, a moving diffuser and a telescope, which adjusts the top-hat area to the field of view. Illumination homogeneity is a critical factor for imaging of UCNP since the intensity of their luminescence typically scales with the second power of the excitation intensity. Our illuminator is combined with the epifluorescence attachment of the microscope, allowing easy switching between observation of UCNP and traditional fluorescent dyes. Illumination profile homogeneity of about 98% was measured for objectives with magnification from 4× to 100×, and the top-hat profile was also obtained with phase contrast objectives. We demonstrate capability of the illuminator by evaluating in vitro uptake of UCNP encapsulated in oleyl-hyaluronan micelles into breast cancer cells. Micelles bearing the targeting peptide were about an order of magnitude more efficient than nontargeted micelles.

  11. The GTC exoplanet transit spectroscopy survey. IV. Confirmation of the flat transmission spectrum of HAT-P-32b

    Nortmann, L; Murgas, F; Dreizler, S; Iro, N; Cabrera-Lavers, A

    2016-01-01

    We observed the hot Jupiter HAT-P-32b (also known as HAT-P-32Ab) to determine its optical transmission spectrum by measuring the wavelength-dependent planet-to-star radius ratios in the region between 518 - 918 nm. We used the OSIRIS instrument at the GTC in long slit spectroscopy mode, placing HAT-P-32 and a reference star in the same slit and obtaining a time series of spectra covering two transit events. Using the best quality data set, we were able to yield 20 narrow-band transit light curves, with each passband spanning a 20 nm wide interval. After removal of all systematic noise signals and light curve modeling the uncertainties for the resulting radius ratios lie between 337 and 972 ppm. The radius ratios show little variation with wavelength suggesting a high altitude cloud layer masking any atmospheric features. Alternatively, a strong depletion in alkali metals or a much smaller than expected planetary atmospheric scale height could be responsible for the lack of atmospheric features. Our result of ...

  12. Ideologiekritik des E-Learnings. Welchen Nutzen hat die Einführung von E-Learning?

    Katharina Kaiser-Müller

    2015-03-01

    Full Text Available Vor etwa sieben Jahren hat das damalige Bundesministerium für Unterricht, Kunst und Kultur (bm:ukk, das seit 2014 Bundesministerium für Bildung und Frauen (BMBF genannt wird, verschiedene Maßnahmen im Blick auf neuen Medien – insbesondere im Blick auf das E-Learning – gesetzt, um einen Beitrag zur Vorbereitung der Lernenden auf eine Informations- und Wissensgesellschaft zu leisten. E-Learning wurde als Erfolgsfaktor für die Zukunft gesehen und mit der Begründung, es fördere das individuelle und selbst gesteuerte Lernen, gefördert. Die zentrale Frage ist dabei: Welchen Nutzen hat die Einführung von E-Learning? In diesem Artikel wird dahingehend aufgezeigt, dass E-Learning nicht wegen pädagogischem Bedarf, sondern durch ministeriell gesetzte Maßnahmen eingeführt wurde und dadurch – wenn auch nicht bewusst und schon gar nicht als solches kommuniziert – neoliberale Strukturen durchgesetzt wurden. Die Einführung von E-Learning hat somit für deren Akzeptanz gesorgt.

  13. Demonstrating High-precision, Multiband Transit Photometry with MuSCAT: A Case for HAT-P-14b

    Fukui, Akihiko; Narita, Norio; Kawashima, Yui; Kusakabe, Nobuhiko; Onitsuka, Masahiro; Ryu, Tsuguru; Ikoma, Masahiro; Yanagisawa, Kenshi; Izumiura, Hideyuki

    2016-03-01

    The Multicolor Simultaneous Camera for studying Atmospheres of Transiting exoplanets (MuSCAT) is an optical three-band ({g}2\\prime -, {r}2\\prime - and {z}{{s},2}-band) imager that was recently developed for the 188 cm telescope at Okayama Astrophysical Observatory with the aim of validating and characterizing transiting planets. In a pilot observation with MuSCAT we observed a primary transit of HAT-P-14b, a high-surface gravity (gp = 38 ms-2) hot Jupiter around a bright (V = 10) F-type star. From a 2.9 hr observation we achieved the five-minute binned photometric precisions of 0.028%, 0.022%, and 0.024% in the {g}2\\prime , {r}2\\prime , and {z}{{s},2} bands, respectively, which provided the highest-quality photometric data for this planet. Combining these results with those of previous observations, we search for variations of transit timing and duration over five years as well as variations of planet-star radius ratio ({R}{{p}}/{R}{{s}}) with wavelengths, but can find no considerable variation in any parameters. On the other hand, using the transit-subtracted light curves we simulate the achievable measurement error of {R}{{p}}/{R}{{s}} with MuSCAT for various planetary sizes, assuming three types of host stars: HAT-P-14, the nearby K-dwarf HAT-P-11, and the nearby M-dwarf GJ1214. Comparing our results with the expected atmospheric scale heights, we find that MuSCAT is capable of probing the atmospheres of planets as small as a sub-Jupiter ({R}{{p}}˜ 6{R}\\oplus ) around HAT-P-14 in all bands, a Neptune (˜ 4{R}\\oplus ) around HAT-P-11 in all bands, and a super-Earth (˜ 2.5{R}\\oplus ) around GJ1214 in {r}2\\prime and {z}{{s},2} bands. These results promise that MuSCAT will produce fruitful scientific outcomes in the K2 and TESS era.

  14. Transmission spectroscopy of the inflated exo-Saturn HAT-P-19b

    Mallonn, M.; von Essen, C.; Weingrill, J.; Strassmeier, K. G.; Ribas, I.; Carroll, T. A.; Herrero, E.; Granzer, T.; Claret, A.; Schwope, A.

    2015-08-01

    Context. Transiting highly inflated giant planets offer the possibility of characterizing their atmospheres. A fraction of the starlight passes through the high-altitude layers of the planetary atmosphere during transit. The resulting absorption is expected to be wavelength dependent for cloud-free atmospheres with an amplitude of up to 10-3 of the stellar flux, while a high-altitude cloud deck would cause a gray opacity. Aims: We observed the Saturn-mass and Jupiter-sized exoplanet HAT-P-19b to refine its transit parameters and ephemeris as well as to shed first light on its transmission spectrum. We monitored the host star over one year to quantify its flux variability and to correct the transmission spectrum for a slope caused by starspots. Methods: A transit of HAT-P-19b was observed spectroscopically with OSIRIS at the Gran Telescopio Canarias in January 2012. The spectra of the target and the comparison star covered the wavelength range from 5600 to 7600 Å. One high-precision differential light curve was created by integrating the entire spectral flux. This white-light curve was used to derive absolute transit parameters. Furthermore, a set of light curves over wavelength was formed by a flux integration in 41 wavelength channels of 50 Å width. We analyzed these spectral light curves for chromatic variations of transit depth. Results: The transit fit of the combined white-light curve yields a refined value of the planet-to-star radius ratio of 0.1390 ± 0.0012 and an inclination of 88.89 ± 0.32 deg. After a re-analysis of published data, we refine the orbital period to 4.0087844 ± 0.0000015 days. We obtain a flat transmission spectrum without significant additional absorption at any wavelength or any slope. However, our accuracy is not sufficient to significantly rule out the presence of a pressure-broadened sodium feature. Our photometric monitoring campaign allowed for an estimate of the stellar rotation period of 35.5 ± 2.5 days and an improved age

  15. VizieR Online Data Catalog: Spectroscopy and photometry of HATS-17 (Brahm+, 2016)

    Brahm, R.; Jordan, A.; Bakos, G. A.; Penev, K.; Espinoza, N.; Rabus, M.; Hartman, J. D.; Bayliss, D.; Ciceri, S.; Zhou, G.; Mancini, L.; Tan, T. G.; de Val-Borro, M.; Bhatti, W.; Csubry, Z.; Bento, J.; Henning, T.; Schmidt, B.; Rojas, F.; Suc, V.; Lazar, J.; Papp, I.; Sari, P.

    2016-07-01

    The star HATS-17 was observed by HATSouth instruments between UT 2011 April 26 and UT 2012 July 31 using the HS-2 (on 2011 Apr-2012 Jul with r filter), HS-4 (on 2011 Jul-2012 Jul with r filter), and HS-6 (on 2011 May-2012 Jul with r filter) units at Las Campanas Observatory (LCO) in Chile, the High Energy Spectroscopic Survey (H.E.S.S.) site in Namibia, and Siding Spring Observatory (SSO) in Australia, respectively. The first photometric follow-up light curve of this system was obtained with the 0.3m Perth Exoplanet Survey Telescope (PEST) located near Perth on 2015 Apr 26 with a RC filter. Another two partial transits were then acquired with the Las Cumbres Observatory Global Telescope (LCOGT) 1m telescope network, specifically with the telescope at Cerro Tololo Inter-American Observatory (CTIO) on 2015 May 13 with i filter, and with the Swope 1m coupled with the e2v camera at Las Campanas Observatory (LCO) on 2015 May 29 with i filter. Finally, two partial transits of the same event were measured with high photometric precision (~1mmag). The observations were performed with the same two telescopes that registered the previous partial transits (Swope 1m/e2v (LCO) on 2015 Jul 17 with i filter, and LCOGT 1 m/sinistro (CTIO) on 2015 Jul 17 with i filter). Several high resolution spectra were acquired with three spectrographs installed in the ESO La Silla observatory. We obtained 11 spectra using HARPS at the ESO 3.6m telescope, 8 spectra using CORALIE, at the Euler 1.2m telescope and 2 spectra with FEROS at the MPG 2.2m telescope. Table2 provides the light curve data. Radial velocity and bisector span values are presented in Table3 with their corresponding uncertainties. (2 data files).

  16. Top hat single-mode polarization maintaining fiber and polarizing numerical design

    Gouriou, Pierre; Scol, Florent; Sevigny, Benoit; Valentin, Constance; Quiquempois, Yves; Bigot, Laurent; Habert, Rémi; Cassez, Andy; Vanvincq, Olivier; Hugonnot, Emmanuel; Bouwmans, Geraud

    2016-03-01

    Compactness, long term stability and no free-space alignment are important advantages of fiber lasers over bulky systems. These fiber lasers have also demonstrated their capability to deliver high-power pulses and are thus suitable for numerous applications. Nevertheless the intensity profile delivered usually has a Gaussian-like shape, which most of the time is sufficient, but it could be interesting, for many applications (laser-biological tissues interactions, heat treatment, industrial laser processing or for seeding large-scale laser facilities like Laser MegaJoule) to obtain a homogeneous intensity profile at the fiber laser output. Moreover several of these applications required a linearly polarized output beam. In order to achieve all these requirements we have developed and realized a new fiber design. This fiber is the first polarization maintaining single-mode fiber delivering a flat top intensity. A high quality flat mode was obtained at 1.05μm through the use of a well-tailored index profile and single-mode behavior was verified by shifting the injection and using the S² imaging. Moreover, boron Stress Applying Parts (SAPs) including in the cladding led to a birefringence of 0.6x10-4 and a measured PER better than 20dB even for a long fiber length (~20 m). Alongside the fabrication, we developed a simulation code, using Comsol Multiphysics®, to take into account the stress dependency induced by the SAPs. Further modeling allows us to present an effectively single-mode fiber design, delivering a top-hat mode profile and exhibiting a polarizing behavior.

  17. Sanitation conditions of clean food good taste restaurants in Hat Yai City Municipality

    Sopon, A.

    2004-01-01

    Full Text Available Sanitation conditions and microbiological quality of 52 “Clean Food Good Taste” restaurants in Hat Yai city municipality were examined using a standard food sanitation survey checklist based on the Department of Health and Department of Medical Science, Ministry of Public Health. Coliform bacteria and Escherichia coli (E. coli were investigated in samples of foods and drinking water, whereas total bacterial count (TBC was carried out in samples of foods, plates, spoons, glasses and food handlers. The methods of investigation were the Most Probable Number (MPN method for coliform bacteria, E. coli and the standard plate count method for TBC. The SI-2 field test kit was used to indicate microbiological contamination, particularly coliform bacteria. It was found that 38/52 (73.1% restaurants passed all items of food sanitation standard. The food sanitation condition with the lowest number passing was the dressing of food handlers (45/52, 86.5% followed by the area for eating, preparing and cooking (47/52, 90.4%. Microbiological quality of food samples based on both MPN of coliform bacteria and E. coli was at an acceptable level in 190/202 samples (94.1%. However, in samples of drinking water only 19/52 (36.5% passed the MPN standard for coliform bacteria and 45/52 (86.5% that for E. coli. Moreover, among the 52 restaurants, the numbers (percentages passing the standard TBC in samples of plate, spoon, glass, cooker handlers and server handlers were 32 (61.5%, 27(51.9%, 20 (38.5%, 2 (3.9% and 1 (1.9%, respectively. Comparison of microbiological quality between the SI-2 test kit and MPN coliform/TBC showed no significant differences for samples of foods, but significant differences for the rest of the samples (p<0.05, t-test.

  18. A progressive black top hat transformation algorithm for estimating valley volumes on Mars

    Luo, Wei; Pingel, Thomas; Heo, Joon; Howard, Alan; Jung, Jaehoon

    2015-02-01

    The depth of valley incision and valley volume are important parameters in understanding the geologic history of early Mars, because they are related to the amount sediments eroded and the quantity of water needed to create the valley networks (VNs). With readily available digital elevation model (DEM) data, the Black Top Hat (BTH) transformation, an image processing technique for extracting dark features on a variable background, has been applied to DEM data to extract valley depth and estimate valley volume. Previous studies typically use a single window size for extracting the valley features and a single threshold value for removing noise, resulting in finer features such as tributaries not being extracted and underestimation of valley volume. Inspired by similar algorithms used in LiDAR data analysis to remove above-ground features to obtain bare-earth topography, here we propose a progressive BTH (PBTH) transformation algorithm, where the window size is progressively increased to extract valleys of different orders. In addition, a slope factor is introduced so that the noise threshold can be automatically adjusted for windows with different sizes. Independently derived VN lines were used to select mask polygons that spatially overlap the VN lines. Volume is calculated as the sum of valley depth within the selected mask multiplied by cell area. Application of the PBTH to a simulated landform (for which the amount of erosion is known) achieved an overall relative accuracy of 96%, in comparison with only 78% for BTH. Application of PBTH to Ma'adim Vallies on Mars not only produced total volume estimates consistent with previous studies, but also revealed the detailed spatial distribution of valley depth. The highly automated PBTH algorithm shows great promise for estimating the volume of VN on Mars on global scale, which is important for understanding its early hydrologic cycle.

  19. Groundwater evolution beneath Hat Yai, a rapidly developing city in Thailand

    Lawrence, A. R.; Gooddy, D. C.; Kanatharana, P.; Meesilp, W.; Ramnarong, V.

    2000-09-01

    Many cities and towns in South and Southeast Asia are unsewered, and urban wastewaters are often discharged either directly to the ground or to surface-water canals and channels. This practice can result in widespread contamination of the shallow groundwater. In Hat Yai, southern Thailand, seepage of urban wastewaters has produced substantial deterioration in the quality of the shallow groundwater directly beneath the city. For this reason, the majority of the potable water supply is obtained from groundwater in deeper semi-confined aquifers 30-50 m below the surface. However, downward leakage of shallow groundwater from beneath the city is a significant component of recharge to the deeper aquifer, which has long-term implications for water quality. Results from cored boreholes and shallow nested piezometers are presented. The combination of high organic content of the urban recharge and the shallow depth to the water table has produced strongly reducing conditions in the upper layer and the mobilisation of arsenic. A simple analytical model shows that time scales for downward leakage, from the surface through the upper aquitard to the semi-confined aquifer, are of the order of several decades. Résumé. De nombreuses villes du sud et du sud-est de l'Asie ne possèdent pas de réseaux d'égouts et les eaux usées domestiques s'écoulent souvent directement sur le sol ou dans des canaux et des cours d'eau de surface. Ces pratiques peuvent provoquer une contamination dispersée de la nappe phréatique. A Hat Yai (sud de la Thaïlande), les infiltrations d'eaux usées domestiques sont responsables d'une détérioration notable de la qualité de la nappe phréatique directement sous la ville. Pour cette raison, la majorité de l'eau potable est prélevée dans des aquifères semi-captifs plus profonds, situés entre 30 et 50 m sous la surface. Cependant, une drainance à partir de la nappe phréatique sous la ville constitue une composante significative de la recharge

  20. Identification of a high frequency transposon induced by tissue culture, nDaiZ, a member of the hAT family in rice.

    Huang, Jian; Zhang, Kewei; Shen, Yi; Huang, Zejun; Li, Ming; Tang, Ding; Gu, Minghong; Cheng, Zhukuan

    2009-03-01

    Recent completion of rice genome sequencing has revealed that more than 40% of its genome consists of repetitive sequences, and most of them are related to inactive transposable elements. In the present study, a transposable element, nDaiZ0, which is induced by tissue culture with high frequency, was identified by sequence analysis of an allelic line of the golden hull and internode 2 (gh2) mutant, which was integrated into the forth exon of GH2. The 528-bp nDaiZ0 has 14-bp terminal inverted repeats (TIRs), and generates an 8-bp duplication of its target sites (TSD) during its mobilization. nDaiZs are non-autonomous transposons and have no coding capacity. Bioinformatics analysis and southern blot hybridization showed that at least 16 copies of nDaiZ elements exist in the japonica cultivar Nipponbare genome and 11 copies in the indica cultivar 93-11 genome. During tissue culture, only one copy, nDaiZ9, located on chromosome 5 in the genome of Nipponbare can be activated with its transposable frequency reaching 30%. However, nDaiZ9 was not present in the 93-11 genome. The larger elements, DaiZs, were further identified by database searching using nDaiZ0 as a query because they share similar TIRs and subterminal sequences. DaiZ can also generate an 8-bp TSD. DaiZ elements contain a conserved region with a high similarity to the hAT dimerization motif, suggesting that the nDaiZ-DaiZ transposon system probably belongs to the hAT superfamily of class II transposons. Phylogenetic analysis indicated that it is a new type of plant hAT-like transposon. Although nDaiZ is activated by tissue culture, the high transposable frequency indicates that it could become a useful gene tagging system for rice functional genomic studies. In addition, the mechanism of the high transposable ability of nDaiZ9 is discussed. PMID:19071208

  1. Treatment efficiency in wastewater treatment plant of Hat Yai Municipality by quantitative removal of microbial indicators

    Duangporn Kantachote

    2009-11-01

    Full Text Available The efficiency of treatment in a wastewater treatment plant of Hat Yai Municipality through stabilization ponds and constructed wetlands was monitored by using the bacterial indicators, total coliforms (TC, fecal coliforms (FC, Escherichia coli and fecal streptococci (FS, and photosynthetic microbes. The sequence of water flow in the wastewater treatment plant is as follows: primary or anaerobic pond (P, facultative pond (F, maturation pond (M, constructed wetlands (W1, W2 and W3, and an effluent storage pond (S for the treated wastewater. The wastewater treatment plant has an approximate area of 3,264,000 m2 (2,040 rai and its dry weather flow was running at only 40,000 m3/ day. There were 10 sampling times used for all the 7 ponds during July-October, 2006.Statistical analysis using a Two-Factorial Design model, indicated that pond types significantly affected temperature, dissolved oxygen (DO, and pH (p<0.05, whereas the time of sampling during the day had a significant effect (p<0.05 only on the temperature and light intensity available to the ponds. There were also significant different removal efficiencies of the different bacterial indicator groups tested (p<0.05. The overall performance of the wastewater treatment plant effectively removed TC, FC, E. coli, and FS as follows, 99.8%, 99.8%, 75.8% and 98.8%, respectively. The amounts of bacterial indicators, except for E. coli, showed a negative correlation with levels of light intensity and DO, whereas there was no correlation between the pH and the different indicator bacteria. There was a positive middle level correlation between pHand chlorophyll a.There were five different divisions of photosynthetic organisms detected throughout the plant as follows, Cyanophyta, Chlorophyta, Bacillariophyta, Euglenophyta, and Pyrrhophyta. The least diversity was found in the anaerobic pond (P as there were only 15 genera. Euglena, an indicator of dirty water, was detected only in this pond. The

  2. Assessment of efficiency of water supply system in Prince of Songkla University, Hat Yai Campus

    Chaivisit, P.

    2007-03-01

    Full Text Available Assessment of efficiency of water production system in Prince of Songkla University, Hat Yai Campus, was conducted in this study. Topics covered include 1 quality and quantity of raw water, 2 water productionprocess, 3 management and maintenance of water production system, and 4 quality of finished water. Totally, 494 water samples were collected during the study. All water samples were analyzed for turbidity,pH, temperature, conductivity, TDS, total coliforms, fecal coliforms and residual chlorine. In addition to the mentioned parameters, 30 of these water samples were also analyzed for hardness, chloride, nitratenitrogen,sulfate and heavy metals (manganese, copper, zinc, iron, chromium, cadmium, lead and mercury. All water samples were collected during November, 2004 (rainy season and March, 2005 (summer season.It was found that the quality of the water in the Sritrang reservoir fell into Class 2 of Thailand Surface Water Quality Standard that requires ordinary water treatment processes prior to consumptions.Cadmium, lead and mercury were not detected by Inductively Coupled Plasma (ICP method. There are 2 sets of water production system. The first set consists of 4 pressure filters which could reduce turbidity atvarying efficiencies: 33.83%, 18.26%, 42.76% and 65.67% depending mainly on the extent of chemical dosing control and the maintenance of the filter media. Another system employed sedimentation tank andrapid sand filter, which could remove turbidity at 89.28%. When combined finished water from both systems were analyzed, it was found that removals of manganese, copper, zinc, iron and chromium were 42.65%,30.02%, 19.54%, 56.82% and 15.12%, respectively. Residual chlorine concentration of the finished water was not more than 0.2 mg/L and no total coliforms or fecal coliforms were detected. The plant had sufficientand competent personnel to carry out their normal tasks but occasional negligence and lack of specific water testing or

  3. A high precision chemical abundance analysis of the HAT-P-1 stellar binary: constraints on planet formation

    Liu, F; Asplund, M.; Ramirez, I.; Yong, D.; Melendez, J.

    2014-01-01

    We present a high-precision, differential elemental abundance analysis of the HAT-P-1 stellar binary based on high-resolution, high signal-to-noise ratio Keck/HIRES spectra. The secondary star in this double system is known to host a transiting giant planet while no planets have yet been detected around the primary star. The derived metallicities ([Fe/H]) of the primary and secondary stars are identical within the errors: $0.146 \\pm 0.014$ dex ($\\sigma$ = 0.033 dex) and $0.155 \\pm 0.007$ dex ...

  4. Hat intrathekal appliziertes Baclofen (Lioresal) einen neuroprotektiven Effekt im 4-Gefäßverschlussmodell der Ratte?

    Stubenvoll, Florian Michael

    2015-01-01

    Einleitung: Im 4-Gefäßverschlussmodell der Ratte wird überprüft, ob intrathekal appliziertes Baclofen einen neuroprotektiven Effekt hat. Material und Methoden: Hierzu werden zunächst 1µg/5µl Baclofen über 5 Minuten beginnend 30 Minuten vor einer 10-minütigen zerebralen Ischämie bei männlichen Wistar-Ratten intrazerebroventrikulär appliziert und gegen eine Kontrollgruppe verglichen, dann werden 2µg/5µl Baclofen über 5 Minu...

  5. The TopHat Experiment: A Balloon-Borne Instrument for Mapping Millimeter and Sub-Millimeter Emission

    Silverberg, R. F.; Cheng, E. S.; Aguirre, J. E.;

    2005-01-01

    The TopHat experiment was designed to measure the anisotropy in the cosmic microwave background radiation on angular scales from 03 to 30° and the thermal emission from both Galactic and extragalactic dust. The balloon‐borne instrument had five spectral bands spanning frequencies from 175 to 630...... GHz. The telescope was a compact, 1 m, on‐axis Cassegrain telescope designed to scan the sky at a fixed elevation of 78°. The radiometer used cryogenic bolometers coupled to a single feed horn via a dichroic filter system. The observing strategy was intended to efficiently cover a region 48° in...

  6. How a Hat May Affect 3-Month-Olds' Recognition of a Face: An Eye-Tracking Study.

    Hermann Bulf; Eloisa Valenza; Chiara Turati

    2013-01-01

    Recent studies have shown that infants’ face recognition rests on a robust face representation that is resilient to a variety of facial transformations such as rotations in depth, motion, occlusion or deprivation of inner/outer features. Here, we investigated whether 3-month-old infants’ ability to represent the invariant aspects of a face is affected by the presence of an external add-on element, i.e. a hat. Using a visual habituation task, three experiments were carried out in which face re...

  7. Top-hat beam output of a single-mode micro-structured optical fiber: Impact of core index depression

    A new strategy to obtain a single-mode fiber with a flattened intensity profile distribution is presented. It is based on the use of an OVD made high index ring deposited on a silica rod having a refractive index slightly lower than the silica used for the micro-structured cladding. Using this strategy, we realized the first single-mode fiber with a quasi-perfect top-hat intensity profile around 1 μm. Numerical studies clearly demonstrate the advantage of using a core index depression to insure the single-mode operation of the fiber at the working wavelength. (authors)

  8. HAT-P-65b and HAT-P-66b: Two Transiting Inflated Hot Jupiters and Observational Evidence for the Re-Inflation of Close-In Giant Planets

    Hartman, Joel D; Bhatti, Waqas; Penev, Kaloyan; Bieryla, Allyson; Latham, David W; Kovács, Géza; Torres, Guillermo; Csubry, Zoltan; de Val-Borro, Miguel; Buchhave, Lars; Kovács, Tamás; Quinn, Samuel; Howard, Andrew W; Isaacson, Howard; Fulton, Benjamin J; Everett, Mark E; Esquerdo, Gilbert A; Béky, Bence; Szklenar, Tamás; Falco, Emilio; Santerne, Alexandre; Boisse, Isabelle; Hébrard, Guillaume; Burrows, Adam; Lázár, Jozsef; Papp, István; Sári, Pál

    2016-01-01

    We present the discovery of the transiting exoplanets HAT-P-65b and HAT-P-66b, with orbital periods of 2.6055 d and 2.9721 d, masses of $0.527 \\pm 0.083$ M$_{J}$ and $0.783 \\pm 0.057$ M$_{J}$ and inflated radii of $1.89 \\pm 0.13$ R$_{J}$ and $1.59^{+0.16}_{-0.10}$ R$_{J}$, respectively. They orbit moderately bright ($V=13.145 \\pm 0.029$, and $V=12.993 \\pm 0.052$) stars of mass $1.212 \\pm 0.050$ M$_{\\odot}$ and $1.255^{+0.107}_{-0.054}$ M$_{\\odot}$. The stars are at the main sequence turnoff. While it is well known that the radii of close-in giant planets are correlated with their equilibrium temperatures, whether or not the radii of planets increase in time as their hosts evolve and become more luminous is an open question. Looking at the broader sample of well-characterized close-in transiting giant planets, we find that there is a statistically significant correlation between planetary radii and the fractional ages of their host stars, with a false alarm probability of only 0.0041%. We find that the correla...

  9. Efficiency Enhancement of Tandem Organic Light-Emitting Devices Fabricated Utilizing an Organic BEDT-TTF and HAT-CN Charge Generation Layer.

    Kim, Dae Hun; Kim, Tae Whan

    2015-10-01

    The electrical and optical properties of tandem organic light-emitting devices (OLEDs) fabricated utilizing an organic bis(ethylenedithio)-tetrathiafulvalene (BEDT-TTF) and 1,4,5,8,9,11-hexaazatriphenylenehexacarbonitrile (HAT-CN) charge generation layer (CGL) were investigated to enhance their efficiency. While the operating voltage of the tandem OLEDs with a BEDT-TTF and HAT-CN CGL at 50 mA/cm2 was 11.2 V lower than that of the tandem OLEDs without a CGL, the current efficiency of the tandem OLEDs with a BEDT-TTF and a HAT-CN CGL at 50 mA/cm2 was 0.8 cd/A higher than that of the tandem OLEDs without a CGL. An increase in the current efficiency and a decrease in the operating voltage of the tandem OLEDs with a BEDT-TTF and an HAT-CN CGL were attributed to the enhancement of the electron injection due to its existence in the highest occupied molecular orbital level of the BEDT-TTF between the HAT-CN and the tris-(8-hydroxyquinoline)aluminum layer. PMID:26726464

  10. HAT-P-57b: A Short-Period Giant Planet Transiting A Bright Rapidly Rotating A8V Star Confirmed Via Doppler Tomography

    Hartman, J D; Buchhave, L A; Torres, G; Latham, D W; Kovács, G; Bhatti, W; Csubry, Z; de Val-Borro, M; Penev, K; Huang, C X; Béky, B; Bieryla, A; Quinn, S N; Howard, A W; Marcy, G W; Johnson, J A; Isaacson, H; Fischer, D A; Noyes, R W; Falco, E; Esquerdo, G A; Knox, R P; Hinz, P; Lázár, J; Papp, I; Sári, P

    2015-01-01

    We present the discovery of HAT-P-57b, a P = 2.4653 day transiting planet around a V = 10.465 +- 0.029 mag, Teff = 7500 +- 250 K main sequence A8V star with a projected rotation velocity of v sin i = 102.1 +- 1.3 km s^-1. We measure the radius of the planet to be R = 1.413 +- 0.054 R_J and, based on RV observations, place a 95% confidence upper limit on its mass of M < 1.85 M_J . Based on theoretical stellar evolution models, the host star has a mass and radius of 1.47 +- 0.12 M_sun, and 1.500 +- 0.050 R_sun, respectively. Spectroscopic observations made with Keck-I/HIRES during a partial transit event show the Doppler shadow of HAT-P-57b moving across the average spectral line profile of HAT-P- 57, confirming the object as a planetary system. We use these observations, together with analytic formulae that we derive for the line profile distortions, to determine the projected angle between the spin axis of HAT-P-57 and the orbital axis of HAT-P-57b. The data permit two possible solutions, with -16.7 deg &l...

  11. Valproic acid exposure decreases Cbp/p300 protein expression and histone acetyltransferase activity in P19 cells.

    Lamparter, Christina L; Winn, Louise M

    2016-09-01

    The teratogenicity of the antiepileptic drug valproic acid (VPA) is well established and its inhibition of histone deacetylases (HDAC) is proposed as an initiating factor. Recently, VPA-mediated HDAC inhibition was demonstrated to involve transcriptional downregulation of histone acetyltransferases (HATs), which was proposed to compensate for the increased acetylation resulting from HDAC inhibition. Cbp and p300 are HATs required for embryonic development and deficiencies in either are associated with congenital malformations and embryolethality. The objective of the present study was to characterize Cbp/p300 following VPA exposure in P19 cells. Consistent with previous studies, exposure to 5mM VPA over 24h induced a moderate decrease in Cbp/p300 mRNA, which preceded a strong decrease in total cellular protein mediated by ubiquitin-proteasome degradation. Nuclear Cbp/p300 protein was also decreased following VPA exposure, although to a lesser extent. Total cellular and nuclear p300 HAT activity was reduced proportionately to p300 protein levels, however while total cellular HAT activity also decreased, nuclear HAT activity was unaffected. Using the Cbp/p300 HAT inhibitor C646, we demonstrated that HAT inhibition similarly affected many of the same endpoints as VPA, including increased reactive oxygen species and caspase-3 cleavage, the latter of which could be attenuated by pre-treatment with the antioxidant catalase. C646 exposure also decreased NF-κB/p65 protein, which was not due to reduced mRNA and was not attenuated with catalase pre-treatment. This study provides support for an adaptive HAT response following VPA exposure and suggests that reduced Cbp/p300 HAT activity could contribute to VPA-mediated alterations. PMID:27381264

  12. KEPLER'S OPTICAL SECONDARY ECLIPSE OF HAT-P-7b AND PROBABLE DETECTION OF PLANET-INDUCED STELLAR GRAVITY DARKENING

    We present observations spanning 355 orbital phases of HAT-P-7 observed by Kepler from 2009 May to 2011 March (Q1-9). We find a shallower secondary eclipse depth than initially announced, consistent with a low optical albedo and detection of nearly exclusively thermal emission, without a reflected light component. We find an approximately 10 ppm perturbation to the average transit light curve near phase –0.02 that we attribute to a temperature decrease on the surface of the star, phased to the orbit of the planet. This cooler spot is consistent with planet-induced gravity darkening, slightly lagging the sub-planet position due to the finite response time of the stellar atmosphere. The brightness temperature of HAT-P-7b in the Kepler bandpass is TB = 2733 ± 21 K and the amplitude of the deviation in stellar surface temperature due to gravity darkening is approximately –0.18 K. The detection of the spot is not statistically unequivocal due its small amplitude, though additional Kepler observations should be able to verify the astrophysical nature of the anomaly.

  13. A high obliquity orbit for the hot-Jupiter HATS-14b transiting a 5400K star

    Zhou, G; Hartman, J D; Fulton, B J; Bakos, G Á; Howard, A W; Isaacson, H; Marcy, G W; Schmidt, B P; Brahm, R; Jordán, A

    2015-01-01

    We report a spin-orbit misalignment for the hot-Jupiter HATS-14b, measuring a projected orbital obliquity of |lambda|= 76 -5/+4 deg. HATS-14b orbits a high metallicity, 5400 K G dwarf in a relatively short period orbit of 2.8 days. This obliquity was measured via the Rossiter-McLaughlin effect, obtained with observations from Keck-HIRES. The velocities were extracted using a novel technique, optimised for low signal-to-noise spectra, achieving a high precision of 4 m/s point-to-point scatter. However, we caution that our uncertainties may be underestimated. Due to the low rotational velocity of the star, the detection significance is dependent on the vsini prior that is imposed in our modelling. Based on trends observed in the sample of hot Jupiters with obliquity measurements, it has been suggested that these planets modify the spin axes of their host stars, with an efficiency that depends on the stellar type and orbital period of the system. In this framework, short-period planets around stars with surface ...

  14. Kepler's Optical Secondary Eclipse of HAT-P-7b and Probable Detection of Planet-Induced Stellar Gravity Darkening

    Morris, Brett M; Deming, Drake

    2013-01-01

    We present observations spanning 355 orbital phases of HAT-P-7 observed by Kepler from May 2009 to March 2011 (Q1-9). We find a shallower secondary eclipse depth than initially announced, consistent with a low optical albedo and detection of nearly exclusively thermal emission, without a reflected light component. We find an approximately 10 ppm perturbation to the average transit light curve near phase -0.02 that we attribute to a temperature decrease on the surface of the star, phased to the orbit of the planet. This cooler spot is consistent with planet-induced gravity darkening, slightly lagging the sub-planet position due to the finite response time of the stellar atmosphere. The brightness temperature of HAT-P-7b in the Kepler bandpass is T_B = 2733 +/- 21 K and the amplitude of the deviation in stellar surface temperature due to gravity darkening is approximately -0.18 K. The detection of the spot is not statistically unequivocal due its small amplitude, though additional Kepler observations should be ...

  15. HAT-P-13b,c: a transiting hot Jupiter with a massive outer companion on an eccentric orbit

    Bakos, G A; Noyes, R W; Hartman, J; Torres, G; Kovacs, Geza; Fischer, D A; Latham, D W; Johnson, J A; Marcy, G W; Sasselov, D D; Stefanik, R P; Sipocz, B; Kovacs, Gabor; Esquerdo, G A; Pal, A; Lázár, J; Papp, I

    2009-01-01

    We report on the discovery of a planetary system with a close-in transiting hot Jupiter on a near circular orbit and a massive outer planet on a highly eccentric orbit. The inner planet, HAT-P-13b, transits the bright V=10.622 G4 dwarf star GSC 3416-00543 every P = 2.916260 \\pm 0.000010 days, with transit epoch Tc = 2454779.92979 \\pm 0.00038 (BJD) and duration 0.1345 \\pm 0.0017 d. The outer planet, HAT-P-13c orbits the star with P2 = 428.5 \\pm 3.0 days and nominal transit center (assuming zero impact parameter) of T2c = 2454870.4 \\pm 1.8 (BJD) or time of periastron passage T2,peri= 2454890.05 \\pm 0.48 (BJD). Transits of the outer planet have not been observed, and may not be present. The host star has a mass of 1.22+0.05-0.10Msun, radius of 1.56 \\pm 0.08 Rsun, effective temperature 5638 \\pm 90K, and is rather metal rich with [Fe/H] = +0.43\\pm0.08. The inner planetary companion has a mass of 0.851+/0.029-/0.046 Mjup, and radius of 1.280\\pm0.079 Rjup yielding a mean density of 0.499+/0.103-/0.069 gcm-3 . The ou...

  16. A Search for Water in the Atmosphere of HAT-P-26b Using LDSS-3C

    Stevenson, Kevin B.; Bean, Jacob L.; Seifahrt, Andreas; Gilbert, Gregory J.; Line, Michael R.; Désert, Jean-Michel; Fortney, Jonathan J.

    2016-02-01

    The characterization of a physically diverse set of transiting exoplanets is an important and necessary step toward establishing the physical properties linked to the production of obscuring clouds or hazes. It is those planets with identifiable spectroscopic features that can most effectively enhance our understanding of atmospheric chemistry and metallicity. The newly commissioned LDSS-3C instrument on Magellan provides enhanced sensitivity and suppressed fringing in the red optical, thus advancing the search for the spectroscopic signature of water in exoplanetary atmospheres from the ground. Using data acquired by LDSS-3C and the Spitzer Space Telescope, we search for evidence of water vapor in the transmission spectrum of the Neptune-mass planet HAT-P-26b. Our measured spectrum is best explained by the presence of water vapor, a lack of potassium, and either a high-metallicity, cloud-free atmosphere or a solar-metallicity atmosphere with a cloud deck at ∼10 mbar. The emergence of multi-scale-height spectral features in our data suggests that future observations at higher precision could break this degeneracy and reveal the planet’s atmospheric chemical abundances. We also update HAT-P-26b’s transit ephemeris, t0 = 2455304.65218(25) BJDTDB, and orbital period, p = 4.2345023(7) days.

  17. Relating $\\hat{q}$, $\\eta/s$ and $\\Delta E$ in an expanding Quark-Gluon Plasma

    Ayala, Alejandro; Jalilian-Marian, Jamal; Tejeda-Yeomans, Maria Elena

    2016-01-01

    We use linear viscous hydrodynamics to describe the energy and momentum deposited by a fast moving parton in a quark gluon plasma. This energy-momentum is in turn used to compute the probability density for the production of soft partons by means of the Cooper-Frye formula. We use this probability density to render manifest a relation between the average transverse momentum given to the fast moving parton from the medium $\\hat{q}$, the entropy density to shear viscosity ratio $\\eta/s$ and the energy lost by the fast moving parton $\\Delta E$ in an expanding medium under similar conditions to those generated in nucleus-nucleus collisions at the LHC. We find that $\\hat{q}$ increases linearly with $\\Delta E$ for both trigger and away side partons that have been produced throughout the medium. On the other hand, $\\eta/s$ is more stable with $\\Delta E$. We also study how these transport coefficients vary with the geometrical location of the hard scattering that produces the fast moving partons. The behavior of $\\ha...

  18. Transmission spectroscopy of HAT-P-32b with the LBT: confirmation of clouds/hazes in the planetary atmosphere

    Mallonn, Matthias

    2016-01-01

    Spectroscopic observations of a transit event of an extrasolar planet offer the opportunity to study the composition of the planetary atmosphere. We observed a transit of the inflated Hot Jupiter HAT-P-32b with MODS at the LBT to characterize its atmosphere from 3300 to 10000 AA. A time series of target and reference star spectra was binned in two broad-band wavelength channels, from which differential transit light curves were constructed. These broad-band light curves were used to confirm previous transit parameter determinations. To derive the planetary transmission spectrum with a resolution of R ~ 60, we created a chromatic set of 62 narrow-band light curves with an average wavelength width of about 100 AA. The spectrum was corrected for the third-light of a near-by M star, whose spectrum was resolved in the individual exposures. Additionally, we undertook a photometric monitoring campaign of the host star to correct for the influence of starspots. The transmission spectrum of HAT-P-32b shows no pressure...

  19. Hint of 150 MHz radio emission from the Neptune-mass extrasolar transiting planet HAT-P-11b

    Etangs, A Lecavelier des; Gopal-Krishna,; Zarka, P

    2013-01-01

    Since the radio-frequency emission from planets is expected to be strongly influenced by their interaction with the magnetic field and corona of the host star, the physics of this process can be effectively constrained by making sensitive measurements of the planetary radio emission. Up to now, however, numerous searches for radio emission from extrasolar planets at radio wavelengths have only yielded negative results. Here we report deep radio observations of the nearby Neptune-mass extrasolar transiting planet HAT-P-11b at 150 MHz, using the Giant Meterwave Radio Telescope (GMRT). On July 16, 2009, we detected a 3-sigma emission whose light curve is consistent with an eclipse when the planet passed behind the star. This emission is at a position 14 arcsec from the transiting exoplanet's coordinates; thus, with a synthetized beam of FWHM~16 arcsec, the position uncertainty of this weak radio signal encompasses the location of HAT-P-11. We estimate a 5% false positive probability that the observed radio light...

  20. Analysis of spin-orbit alignment in the WASP-32, WASP-38, and HAT-P-27/WASP-40 systems

    Brown, D J A; Díaz, R F; Doyle, A P; Gillon, M; Lendl, M; Smalley, B; Triaud, A H M J; Anderson, D R; Enoch, B; Hellier, C; Maxted, P F L; Miller, G R M; Pollacco, D; Queloz, D; Boisse, I; Hébrard, G; 10.1088/0004-637X/760/2/139

    2013-01-01

    We present measurements of the spin-orbit alignment angle, lambda, for the hot Jupiter systems WASP-32, WASP-38, and HAT-P-27/WASP-40, based on data obtained using the HARPS spectrograph. We analyse the Rossiter-McLaughlin effect for all three systems, and also carry out Doppler tomography for WASP-32 and WASP-38. We find that WASP-32 (T_eff = 6140 +90 -100 K) is aligned, with an alignment angle of lambda = 10.5 +6.4 -6.5 degrees obtained through tomography, and that WASP-38 (T_eff = 6180 +40 -60 K) is also aligned, with tomographic analysis yielding lambda = 7.5 +4.7 -6.1 degrees. This latter result provides an order of magnitude improvement in the uncertainty in lambda compared to the previous analysis of Simpson et al. (2011). We are only able to loosely constrain the angle for HAT-P-27/WASP-40 (T_eff = 5190 +160 -170 K) to lambda = 24.2 +76.0 -44.5 degrees, owing to the poor signal-to-noise of our data. We consider this result a non-detection under a slightly updated version of the alignment test of Brown...

  1. Probe-beam diffraction in a pulsed top-hat beam thermal lens with a mode-mismatched configuration.

    Li, B; Welsch, E

    1999-08-20

    The Fresnel diffraction integral is used directly to describe the thermal lens (TL) effect with a mode-mismatched collinear configuration. The TL amplitudes obtained with Gaussian, Airy, and top-hat beam excitations are computed and compared. Numerical results for beam geometries optimized for both near- and far-field detection schemes are presented, and the analytical results developed by Bialkowski and Chartier [Appl. Opt. 36, 6711 (1997)] for a Gaussian beam TL effect are summarized in simplified form. Both the numerical and the analytical results demonstrate that, under a beam geometry optimized for either near- or far-field detection, the Gaussian beam TL experiment has approximately the same maximum signal amplitude as does the photothermal-interference scheme. A comparison between the optimum near- and far-field detection beam geometries indicates that a practical mode-mismatched TL instrument should be based on the far-field detection geometry. The computation results further demonstrate that the optimum beam geometry and the TL amplitude depend largely on the excitation-beam profile. The top-hat beam TL experiment is approximately twice as sensitive as the Gaussian beam TL scheme. PMID:18324024

  2. Uzgoj običnoga jelena (Cervus elaphus L.) u kontroliranim uvjetima u ograđenom prostoru Šeprešhat

    Grubešić, Marijan; Urošević, Branko; Mihaljević, Zlatan; Tomljanović, Kristijan

    2011-01-01

    Ograđeni prostor Šeprešhat namijenjen je intenzivnomu uzgoju običnoga jelena u kontroliranim uvjetima. Svrha je takva uzgoja proizvodnja visokovrijednoga baranjskoga jelena s mogućnošću distribucije kvalitetnoga rasplodnoga materijala u druga lovišta Republike Hrvatske. Uzgoj je jelena započeo još 2002. godine s prvim hvatanjima i ispuštanjima teladi u ograđeni prostor. Ograđeni prostor Šeprešhat u međuvremenu se postupno širio te od početnih 53 ha danas ima 380 ha. Prostor je razdijeljen na ...

  3. Coupling quantum dots to optical fiber: Low pump threshold laser in the red with a near top hat beam profile

    Direct coupling of the optical field in a ∼244 nm thick, CdSe/ZnS quantum dot film to an optical fiber has yielded lasing in the red (λ ∼ 644 nm) with a threshold pump energy density < 2.6 mJ cm−2. Comprising 28–31 layers of ∼8 nm diameter quantum dots deposited onto the exterior surface of a 125 μm diameter coreless silica fiber, this free-running oscillator produces 134 nJ in 3.6 ns FWHM pulses which correspond to 37 W of peak power from an estimated gain volume of ∼4.5 × 10−7 cm3. Lasing was confirmed by narrowing of the output optical radiation in both the spectral and temporal domains, and the laser beam intensity profile approximates a top hat

  4. The Spectrum of Integrated Millimeter Flux of the Magellanic Clouds and 30-Doradus from TopHat and DIRBE Data

    Aguirre, J E; Cheng, E S; Cottingham, D A; Cordone, S S; Crawford, T M; Fixsen, D J; Knox, L; Meyer, S S; Norgaard-Nielsen, H U; Silverberg, R F; Timbie, P; Wilson, G W

    2003-01-01

    We present measurements of the integrated flux relative to the local background of the Large and Small Magellanic Clouds and the region 30-Doradus (the Tarantula Nebula) in the LMC in four frequency bands centered at 245, 400, 460, and 630 GHz, based on observations made with the TopHat telescope. We combine these observations with the corresponding measurements for the DIRBE bands 8, 9, and 10 to cover the frequency range 245 - 3000 GHz (100 - 1220 micrometers) for these objects. We present spectra for all three objects and fit these spectra to a single-component greybody emission model and report best-fit dust temperatures, optical depths, and emissivity power-law indices, and we compare these results with other measurements in these regions and elsewhere. Using published dust grain opacities, we estimate the mass of the measured dust component in the three regions.

  5. Classical and Mexican hat-type potential energy curve for the hydrogen molecule from a confined Kratzer oscillator

    van Hooydonk, G.

    2016-03-01

    We review harmonic oscillator theory for closed, stable quantum systems. The H2 potential energy curve (PEC) of Mexican hat-type, calculated with a confined Kratzer oscillator, is better than the Rydberg-Klein-Rees (RKR) H2 PEC. Compared with QM, the theory of chemical bonding is simplified, since a confined Kratzer oscillator can also lead to the long sought for universal function, once called the Holy Grail of Molecular Spectroscopy. This is validated by reducing PECs for different bonds H2, HF, I2, N2 and O2 to a single one. The equal probability for H2, originating either from HA + HB or HB + HA, is quantified with a Gauss probability density function. At the Bohr scale, a confined harmonic oscillator behaves properly at the extremes of bound two-nucleon quantum systems.

  6. Is $\\hat{q}$ a physical quantity or just a parameter? and other unanswered questions in High-$p_T$ Physics

    Tannenbaum, M J

    2015-01-01

    The many different theoretical studies of energy loss of a quark or gluon traversing a medium have one thing in common: the transport coefficient of a gluon in the medium, $\\hat{q}$, which is defined as the mean 4-momentum transfer$^2$, $\\left$, by a gluon to the medium per gluon mean free path, $\\lambda_{\\rm mfp}$. In the original BDMPSZ formalism, the energy loss of an outgoing parton, $-dE/dx$, per unit length ($x$) of a medium with total length $L$, due to coherent gluon bremsstrahlung, is proportional to the $\\left$ and takes the form: ${-dE/dx }\\simeq \\alpha_s \\left=\\alpha_s\\, \\mu^2\\, L/\\lambda_{\\rm mfp} =\\alpha_s\\, \\hat{q}\\, L\\ $ , where $\\mu$, is the mean momentum transfer per collision. Thus, the total energy loss in the medium goes like $L^2$. Additionally, the accumulated momentum$^2$, $\\left$, transverse to a gluon traversing a length $L$ in the medium is well approximated by $\\left\\approx\\left=\\hat{q}\\, L$. A simple estimate shows that the $\\left\\approx\\hat{q}\\,L$ should be observable at RHIC at ...

  7. Activation of AML1-mediated transcription by MOZ and inhibition by the MOZ–CBP fusion protein

    Kitabayashi, Issay; Aikawa, Yukiko; Nguyen, Lan Anh; Yokoyama, Akihiko; Ohki, Misao

    2001-01-01

    The AML1–CBFβ transcription factor complex is the most frequent target of specific chromosome translocations in human leukemia. The MOZ gene, which encodes a histone acetyltransferase (HAT), is also involved in some leukemia-associated translocations. We report here that MOZ is part of the AML1 complex and strongly stimulates AML1-mediated transcription. The stimulation of AML1-mediated transcription is independent of the inherent HAT activity of MOZ. Rather, a potent transactivation domain w...

  8. Phase II, Title I engineering assessment of inactive uranium mill tailings, Mexican Hat site, Mexican Hat, Utah. [Environmental effects, health hazards, and options for stabilization of tailings and fencing or decontamination of sites

    None

    1977-03-31

    An engineering assessment of the problems resulting from the existence of radioactive uranium mill tailings at the Mexican Hat millsite in Utah is presented. Topographic maps, data on core drillings and radiometric measurements sufficient to determine areas and volumes of tailings and other radium-contaminated materials, the evaluation of resulting radiation exposures of individuals residing nearby, the investigation of site hydrology and meteorology, and the evaluation and costing of alternative corrective actions are presented. Radon gas release from the 2,200,000 tons of tailings on the site constitutes the most significant environmental impact. T he six alternative actions presented are directed towards restricting access to the site, returning the windblown tailings to the piles and stabilizing the piles with cover material, and consolidating the two piles into one pile and stabilizing it with cover material. Fencing around the site or the tailings and the decontamination of mill buildings is included in all options. Costs of the options range from $370,000 to $4,390,000.

  9. Comparative analysis of the recently discovered hAT transposon TcBuster in human cells.

    Lauren E Woodard

    Full Text Available BACKGROUND: Transposons are useful tools for creating transgenic organisms, insertional mutagenesis, and genome engineering. TcBuster, a novel hAT-family transposon system derived from the red flour beetle Tribolium castaneum, was shown to be highly active in previous studies in insect embryoes. METHODOLOGY/PRINCIPAL FINDINGS: We tested TcBuster for its activity in human embryonic kidney 293 (HEK-293 cells. Excision footprints obtained from HEK-293 cells contained small insertions and deletions consistent with a hAT-type repair mechanism of hairpin formation and non-homologous end-joining. Genome-wide analysis of 23,417 piggyBac, 30,303 Sleeping Beauty, and 27,985 TcBuster integrations in HEK-293 cells revealed a uniquely different integration pattern when compared to other transposon systems with regards to genomic elements. TcBuster experimental conditions were optimized to assay TcBuster activity in HEK-293 cells by colony assay selection for a neomycin-containing transposon. Increasing transposon plasmid increased the number of colonies, whereas gene transfer activity dependent on codon-optimized transposase plasmid peaked at 100 ng with decreased colonies at the highest doses of transposase DNA. Expression of the related human proteins Buster1, Buster3, and SCAND3 in HEK-293 cells did not result in genomic integration of the TcBuster transposon. TcBuster, Tol2, and piggyBac were compared directly at different ratios of transposon to transposase and found to be approximately comparable while having their own ratio preferences. CONCLUSIONS/SIGNIFICANCE: TcBuster was found to be highly active in mammalian HEK-293 cells and represents a promising tool for mammalian genome engineering.

  10. The GROUSE project II: Detection of the Ks-band secondary eclipse of exoplanet HAT-P-1b

    de Mooij, E J W; Nefs, S V; Snellen, I A G

    2011-01-01

    Context: Only recently it has become possible to measure the thermal emission from hot-Jupiters at near-Infrared wavelengths using ground-based telescopes, by secondary eclipse observations. This allows the planet flux to be probed around the peak of its spectral energy distribution, which is vital for the understanding of its energy budget. Aims: The aim of the reported work is to measure the eclipse depth of the planet HAT-P-1b at 2.2micron. This planet is an interesting case, since the amount of stellar irradiation it receives falls in between that of the two best studied systems (HD209458 and HD189733), and it has been suggested to have a weak thermal inversion layer. Methods: We have used the LIRIS instrument on the William Herschel Telescope (WHT) to observe the secondary eclipse of HATP-1b in the Ks-band, as part of our Ground-based secondary eclipse (GROUSE) project. The observations were done in staring mode, while significantly defocusing the telescope to avoid saturation on the K=8.4 star. With an ...

  11. The effects of angiotensinogen gene polymorphisms on cardiovascular disease outcomes during antihypertensive treatment in the GenHAT study

    AnhN.Do

    2014-09-01

    Full Text Available Previous studies have reported that risk of cardiovascular morbidity and mortality substantially increases in hypertensive patients, especially among those with inadequate blood pressure control. Two common antihypertensive drug classes including thiazide diuretics and angiotensinogen converting enzyme (ACE inhibitors affect different enzymes in the renin angiotensinogen aldosterone system (RAAS. In the RAAS, angiotensinogen is converted into angiotensin II which increases blood pressure through vasoconstriction. Using a case-only design with 3,448 high-risk hypertensive individuals from the Genetics of Hypertension Associated Treatment (GenHAT study, we examined whether 7 single nucleotide polymorphisms (SNPs in the angiotensinogen gene (AGT interact with three classes of antihypertensive drugs including chlorthalidone (a thiazide diuretic, lisinopril (an ACE inhibitor, and amlodipine (a calcium channel blocker to modify the risk of incident coronary heart disease (CHD and heart failure (HF among Caucasian and African American participants, separately. We found no gene by treatment interactions to be statistically significant after correction for multiple testing. However, some suggestive results were found. African American participants with the minor allele of rs11122576 had over two-fold higher risk of CHD when using chlorthalidone compared to using amlodipine, or lisinopril compared to amlodipine (p=0.006, and p=0.01, respectively. Other marginal associations are also reported among both race groups. The findings reported here suggest that rs11122576 could contribute to future personalization of antihypertensive treatment among African Americans though more studies are needed.

  12. GTC OSIRIS transiting exoplanet atmospheric survey: detection of potassium in HAT-P-1b from narrowband spectrophotometry

    Wilson, P A; Nikolov, N; Etangs, A Lecavelier des; Pont, F; Fortney, J J; Ballester, G E; López-Morales, M; Désert, J -M; Vidal-Madjar, A

    2015-01-01

    We present the detection of potassium in the atmosphere of HAT-P-1b using optical transit narrowband photometry. The results are obtained using the 10.4 m Gran Telescopio Canarias (GTC) together with the OSIRIS instrument in tunable filter imaging mode. We observed four transits, two at continuum wavelengths outside the potassium feature, at 6792 {\\AA} and 8844 {\\AA}, and two probing the potassium feature in the line wing at 7582.0 {\\AA} and the line core at 7664.9 {\\AA} using a 12 {\\AA} filter width (R~650). The planet-to-star radius ratios in the continuum are found to be $R_{\\rm{pl}}/R_{\\star}$ = 0.1176 $\\pm$ 0.0013 at 6792 {\\AA} and $R_{\\rm{pl}}/R_{\\star}$ = 0.1168 $\\pm$ 0.0022 at 8844 {\\AA}, significantly lower than the two observations in the potassium line: $R_{\\rm{pl}}/R_{\\star}$ = 0.1248 $\\pm$ 0.0014 in the line wing at 7582.0 {\\AA} and $R_{\\rm{pl}}/R_{\\star}$ = 0.1268 $\\pm$ 0.0012 in the line core at 7664.9 {\\AA}. With a weighted mean of the observations outside the potassium feature $R_{\\rm{pl}}/R_...

  13. THE TRANSIT LIGHT-CURVE PROJECT. XIV. CONFIRMATION OF ANOMALOUS RADII FOR THE EXOPLANETS TrES-4b, HAT-P-3b, AND WASP-12b

    We present transit photometry of three exoplanets, TrES-4b, HAT-P-3b, and WASP-12b, allowing for refined estimates of the systems' parameters. TrES-4b and WASP-12b were confirmed to be 'bloated' planets, with radii of 1.706 ± 0.056RJup and 1.736 ± 0.092RJup, respectively. These planets are too large to be explained with standard models of gas giant planets. In contrast, HAT-P-3b has a radius of 0.827 ± 0.055RJup, smaller than a pure hydrogen-helium planet and indicative of a highly metal-enriched composition. Analyses of the transit timings revealed no significant departures from strict periodicity. For TrES-4, our relatively recent observations allow for improvement in the orbital ephemerides, which is useful for planning future observations.

  14. The Transit Light Curve project. XIV. Confirmation of Anomalous Radii for the Exoplanets TrES-4b, HAT-P-3b, and WASP-12b

    Chan, Tucker; Winn, Joshua N; Holman, Matthew J; Sanchis-Ojeda, Roberto; Esquerdo, Gil; Everett, Mark

    2011-01-01

    We present transit photometry of three exoplanets, TrES-4b, HAT-P-3b, and WASP-12b, allowing for refined estimates of the systems' parameters. TrES-4b and WASP-12b were confirmed to be "bloated" planets, with radii of 1.706 +/- 0.056 R_Jup and 1.736 +/- 0.092 R_Jup, respectively. These planets are too large to be explained with standard models of gas giant planets. In contrast, HAT-P-3b has a radius of 0.827 +/- 0.055 R_Jup, smaller than a pure hydrogen-helium planet and indicative of a highly metal-enriched composition. Analyses of the transit timings revealed no significant departures from strict periodicity. For TrES-4, our relatively recent observations allow for improvement in the orbital ephemerides, which is useful for planning future observations.

  15. New ${\\cal W}_{q,p}(sl(2))$ algebras from the elliptic algebra ${\\cal A}_{q,p}({\\hat sl}(2)_c)$

    Avan, J; Rossi, M; Sorba, Paul

    1997-01-01

    We construct operators t(z) in the elliptic algebra introduced by Foda et al. ${\\cal A}_{q,p}({\\hat sl}(2)_c)$. They close an exchange algebra when p^m=q^{c+2} for m integer. In addition they commute when p=q^{2k} for k integer non-zero, and they belong to the center of ${\\cal A}_{q,p}({\\hat sl}(2)_c)$ when k is odd. The Poisson structures obtained for t(z) in these classical limits are identical to the q-deformed Virasoro Poisson algebra, characterizing the exchange algebras at generic values of p, q and m as new ${\\cal W}_{q,p}(sl(2))$ algebras.

  16. A computational method for solving stochastic Itô–Volterra integral equations based on stochastic operational matrix for generalized hat basis functions

    Heydari, M.H., E-mail: heydari@stu.yazd.ac.ir [Faculty of Mathematics, Yazd University, Yazd (Iran, Islamic Republic of); The Laboratory of Quantum Information Processing, Yazd University, Yazd (Iran, Islamic Republic of); Hooshmandasl, M.R., E-mail: hooshmandasl@yazd.ac.ir [Faculty of Mathematics, Yazd University, Yazd (Iran, Islamic Republic of); The Laboratory of Quantum Information Processing, Yazd University, Yazd (Iran, Islamic Republic of); Maalek Ghaini, F.M., E-mail: maalek@yazd.ac.ir [Faculty of Mathematics, Yazd University, Yazd (Iran, Islamic Republic of); The Laboratory of Quantum Information Processing, Yazd University, Yazd (Iran, Islamic Republic of); Cattani, C., E-mail: ccattani@unisa.it [Department of Mathematics, University of Salerno, Fisciano (Italy)

    2014-08-01

    In this paper, a new computational method based on the generalized hat basis functions is proposed for solving stochastic Itô–Volterra integral equations. In this way, a new stochastic operational matrix for generalized hat functions on the finite interval [0,T] is obtained. By using these basis functions and their stochastic operational matrix, such problems can be transformed into linear lower triangular systems of algebraic equations which can be directly solved by forward substitution. Also, the rate of convergence of the proposed method is considered and it has been shown that it is O(1/(n{sup 2}) ). Further, in order to show the accuracy and reliability of the proposed method, the new approach is compared with the block pulse functions method by some examples. The obtained results reveal that the proposed method is more accurate and efficient in comparison with the block pule functions method.

  17. HAT-P-57b: A Short-period Giant Planet Transiting a Bright Rapidly Rotating A8V Star Confirmed Via Doppler Tomography

    Hartman, J. D.; Bakos, G. Á.; Buchhave, L. A.; Torres, G.; Latham, D. W.; Kovács, G.; Bhatti, W.; Csubry, Z.; de Val-Borro, M.; Penev, K.; Huang, C. X.; Béky, B.; Bieryla, A.; Quinn, S. N.; Howard, A. W.; Marcy, G. W.; Johnson, J. A.; Isaacson, H.; Fischer, D. A.; Noyes, R. W.; Falco, E.; Esquerdo, G. A.; Knox, R. P.; Hinz, P.; Lázár, J.; Papp, I.; Sári, P.

    2015-12-01

    We present the discovery of HAT-P-57b, a P = 2.4653 day transiting planet around a V=10.465+/- 0.029 mag, {T}{{eff}}=7500+/- 250 K main sequence A8V star with a projected rotation velocity of v{sin}i=102.1+/- 1.3 {km} {{{s}}}-1. We measure the radius of the planet to be R=1.413+/- 0.054 {R}{{J}} and, based on RV observations, place a 95% confidence upper limit on its mass of M\\lt 1.85 {M}{{J}}. Based on theoretical stellar evolution models, the host star has a mass and radius of 1.47+/- 0.12 {M}⊙ and 1.500+/- 0.050 {R}⊙ , respectively. Spectroscopic observations made with Keck-I/HIRES during a partial transit event show the Doppler shadow of HAT-P-57b moving across the average spectral line profile of HAT-P-57, confirming the object as a planetary system. We use these observations, together with analytic formulae that we derive for the line profile distortions, to determine the projected angle between the spin axis of HAT-P-57 and the orbital axis of HAT-P-57b. The data permit two possible solutions, with -16\\buildrel{\\circ}\\over{.} 7\\lt λ \\lt 3\\buildrel{\\circ}\\over{.} 3 or 27\\buildrel{\\circ}\\over{.} 6\\lt λ \\lt 57\\buildrel{\\circ}\\over{.} 4 at 95% confidence, and with relative probabilities for the two modes of 26% and 74%, respectively. Adaptive optics imaging with MMT/Clio2 reveals an object located 2\\buildrel{\\prime\\prime}\\over{.} 7 from HAT-P-57 consisting of two point sources separated in turn from each other by 0\\buildrel{\\prime\\prime}\\over{.} 22. The H- and {L}\\prime -band magnitudes of the companion stars are consistent with their being physically associated with HAT-P-57, in which case they are stars of mass 0.61+/- 0.10 {M}⊙ and 0.53+/- 0.08 {M}⊙ . HAT-P-57 is the most rapidly rotating star, and only the fourth main sequence A star, known to host a transiting planet. Based on observations obtained with the Hungarian-made Automated Telescope Network. Based in part on observations made with the Keck-I telescope at Mauna

  18. Remedial Action Plan and site design for stabilization of the inactive uranium mill tailings site at Mexican Hat, Utah: Appendix D. Final report

    NONE

    1988-07-01

    This appendix is an assessment of the present conditions of the inactive uranium mill site near Mexican Hat, Utah. It consolidates available engineering, radiological, geotechnical, hydrological, meteorological, and other information pertinent to the design of the Remedial Action Plan. Plan is to characterize the conditions at the mill and tailings site so that the Remedial Action Contractor may complete final designs of the remedial action.

  19. HATS-6b: A Warm Saturn Transiting an Early M Dwarf Star, and a Set of Empirical Relations for Characterizing K and M Dwarf Planet Hosts

    Hartman, J D; Brahm, R; Bakos, G Á; Mancini, L; Jordán, A; Penev, K; Rabus, M; Zhou, G; Butler, R P; Espinoza, N; de Val-Borro, M; Bhatti, W; Csubry, Z; Ciceri, S; Henning, T; Schmidt, B; Arriagada, P; Shectman, S; Crane, J; Thompson, I; Suc, V; Csák, B; Tan, T G; Noyes, R W; Lázár, J; Papp, I; Sári, P

    2014-01-01

    We report the discovery by the HATSouth survey of HATS-6b, an extrasolar planet transiting a V=15.2 mag, i=13.7 mag M1V star with a mass of 0.57 Msun and a radius of 0.57 Rsun. HATS-6b has a period of P = 3.3253 d, mass of Mp=0.32 Mjup, radius of Rp=1.00 Rjup, and zero-albedo equilibrium temperature of Teq=712.8+-5.1 K. HATS-6 is one of the lowest mass stars known to host a close-in gas giant planet, and its transits are among the deepest of any known transiting planet system. We discuss the follow-up opportunities afforded by this system, noting that despite the faintness of the host star, it is expected to have the highest K-band S/N transmission spectrum among known gas giant planets with Teq < 750 K. In order to characterize the star we present a new set of empirical relations between the density, radius, mass, bolometric magnitude, and V, J, H and K-band bolometric corrections for main sequence stars with M < 0.80 Msun, or spectral types later than K5. These relations are calibrated using eclipsing...

  20. HAT-P-24b: An inflated hot-Jupiter on a 3.36d period transiting a hot, metal-poor star

    Kipping, D M; Hartman, J; Torres, G; Shporer, A; Latham, D W; Kovacs, Geza; Noyes, R W; Howard, A W; Fischer, D A; Johnson, J A; Marcy, G W; Beky, B; Perumpilly, G; Esquerdo, G A; Sasselov, D D; Stefanik, R P; Lazar, J; Papp, I; Sari, P

    2010-01-01

    We report the discovery of HAT-P-24b, a transiting extrasolar planet orbiting the moderately bright V=11.818 F8 dwarf star GSC 0774-01441, with a period P = 3.3552464 +/- 0.0000071 d, transit epoch Tc = 2455216.97669 +/- 0.00024 (BJD_UTC), and transit duration 3.653 +/- 0.025 hours. The host star has a mass of 1.186 +/- 0.042 Msun , radius of 1.294 +/- 0.071 Rsun , effective temperature 6373 +/- 80 K, and a low metallicity of [Fe/H] = -0.16 +/- 0.08. The planetary companion has a mass of 0.681 +/- 0.031 MJ , and radius of 1.243 +/- 0.072 RJ yielding a mean density of 0.439 +/- 0.069 g cm-3 . By repeating our global fits with different parameter sets, we have performed a critical investigation of the fitting techniques used for previous HAT planetary discoveries. We find that the system properties are robust against the choice of priors. The effects of fixed versus fitted limb darkening are also examined. HAT-P-24b probably maintains a small eccentricity of e = 0.052 +0.022 -0.017, which is accepted over the c...

  1. The application of the Mid-IR radio correlation to the $\\hat{G}$ sample and the search for advanced extraterrestrial civilisations

    Garrett, Michael

    2015-01-01

    Wright et al. 2014 have embarked on a search for advanced Karadashev Type III civilisations via the compilation of a sample of sources with extreme mid-IR emission and colours. In this scenario, the mid-IR emission is then primarily associated with waste heat energy by-products. I apply the Mid-IR radio correlation to this $\\hat{G}$ sample (Griffith et al. 2015). I demonstrate that the mid-IR and radio luminosities are correlated for the sample with $q_{22}=1.35\\pm0.42 $. By comparison, the First Look Survey (FLS) has $q_{22}=0.87\\pm0.27$. The fact that the G-HAT sample largely follows the Mid-IR radio correlation, strongly suggests the vast majority of these sources are associated with galaxies in which natural astrophysical processes are dominant. This simple application of the mid-IR radio correlation can substantially reduce the number of false positives in the $\\hat{G}$ catalogue, since galaxies occupied by advanced Kardashev Type III civilisations would be expected to exhibit very high values of $q$. In...

  2. Transmission spectroscopy of HAT-P-32b with the LBT: confirmation of clouds/hazes in the planetary atmosphere

    Mallonn, M.; Strassmeier, K. G.

    2016-05-01

    Aims: Spectroscopic observations of a transit event of an extrasolar planet offer the opportunity to study the composition of the planetary atmosphere. This can be done with comparably little telescope time using a low-resolution multi-object spectrograph at a large aperture telescope. We observed a transit of the inflated hot Jupiter HAT-P-32b with the Multi-Object Double Spectrograph at the Large Binocular Telescope to characterize its atmosphere from 3300 to 10 000 Å. Methods: A time series of target and reference star spectra was binned in two broad-band wavelength channels, from which differential transit light curves were constructed. These broad-band light curves were used to confirm previous transit parameter determinations. To derive the planetary transmission spectrum with a resolution of R ~ 60, we created a chromatic set of 62 narrow-band light curves. The spectrum was corrected for the third light of a nearby M star. Additionally, we undertook a photometric monitoring campaign of the host star to correct for the influence of starspots. Results: The transmission spectrum of HAT-P-32b shows no pressure-broadened absorption features from Na and K, which is interpreted by the presence of clouds or hazes in the planetary atmosphere. This result is in agreement with previous studies on the same planet. The presence of TiO in gas phase could be ruled out. We find a 2.8σ indication of increased absorption in the line core of potassium (K I 7699 Å). No narrow absorption features of Na and Hα were detected. Furthermore, tentative indications were found for a slope of increasing opacity toward blue wavelengths from the near-IR to the near-UV with an amplitude of two scale heights. If confirmed by follow-up observations, it can be explained by aerosols either causing Mie scattering or causing Rayleigh scattering with an aerosol - gas scale height ratio below unity. The host star was found to be photometrically stable within the measurement precision. Based on

  3. THE STELLAR OBLIQUITY AND THE LONG-PERIOD PLANET IN THE HAT-P-17 EXOPLANETARY SYSTEM

    Fulton, Benjamin J.; Howard, Andrew W. [Institute for Astronomy, University of Hawaii at Manoa, 2680 Woodlawn Dr, Honolulu, HI 96822 (United States); Winn, Joshua N.; Albrecht, Simon [Department of Physics and Kavli Institute for Astrophysics and Space Research, Massachusetts Institute of Technology, Cambridge, MA 02139 (United States); Marcy, Geoffrey W.; Isaacson, Howard [University of California, Berkeley, Berkeley, CA (United States); Crepp, Justin R. [University of Notre Dame, Department of Physics, Notre Dame, IN (United States); Bakos, Gaspar A.; Hartman, Joel D. [Princeton University, Department of Astrophysical Sciences, Princeton, NJ (United States); Johnson, John Asher; Knutson, Heather A. [California Institute of Technology, Pasadena, CA (United States); Zhao Ming [Department of Astronomy and Astrophysics, 525 Davey Laboratory, Pennsylvania State University, University Park, PA 16802 (United States)

    2013-08-01

    We present the measured projected obliquity-the sky-projected angle between the stellar spin axis and orbital angular momentum-of the inner planet of the HAT-P-17 multi-planet system. We measure the sky-projected obliquity of the star to be {lambda}=19{sup +14}{sub -16} deg by modeling the Rossiter-McLaughlin effect in Keck/HIRES radial velocities (RVs). The anomalous RV time series shows an asymmetry relative to the midtransit time, ordinarily suggesting a nonzero obliquity-but in this case at least part of the asymmetry may be due to the convective blueshift, increasing the uncertainty in the determination of {lambda}. We employ the semi-analytical approach of Hirano et al. that includes the effects of macroturbulence, instrumental broadening, and convective blueshift to accurately model the anomaly in the net RV caused by the planet eclipsing part of the rotating star. Obliquity measurements are an important tool for testing theories of planet formation and migration. To date, the measured obliquities of {approx}50 Jovian planets span the full range, from prograde to retrograde, with planets orbiting cool stars preferentially showing alignment of stellar spins and planetary orbits. Our results are consistent with this pattern emerging from tidal interactions in the convective envelopes of cool stars and close-in planets. In addition, our 1.8 yr of new RVs for this system show that the orbit of the outer planet is more poorly constrained than previously thought, with an orbital period now in the range of 10-36 yr.

  4. 人β-珠蛋白核基质附着区介导表达载体稳定附着于中国仓鼠卵巢细胞%Expression vector mediated by human β-globin matrix attachment region functions as stable episomes in Chinese hamster ovary cells

    吴向楠; 王天云; 杨瑞; 王俪; 王芳

    2013-01-01

    目的 研究人β-珠蛋白核基质附着区是否能够介导表达载体稳定附着于中国仓鼠卵巢(CHO)细胞.方法 人β-珠蛋白MAR序列克隆到pEGFP-C1构建重组质粒载体pEGFP-MAR,转染CHO细胞,使用Hirt裂解法提取细胞中附着体质粒,CaCI2法转化附着体质粒到宿主大肠杆菌DH5a中,提取质粒,酶切,测序分析.结果 还原质粒双酶切和单酶切结果均与转染前质粒酶切结果一致;测序分析得知还原质粒与转染前质粒中插入片段DNA序列相同.结论 人β-珠蛋白MAR序列重组载体在CHO细胞中以附着体形式被完整还原出来.还原质粒酶切结果和测序结果均与转染前质粒一致.%Objective To study the human β-globin matrix attachment region(MAR) sequence mediated vector whether exist as stable episomes in transfected Chinese hamster ovary(CHO) cells.Methods Recombinant plasmid vector pEGFPMAR was constructed by thrusting the amplified human β-globin MAR sequence into the parental pEGFP-C1.CHO cells were transfected both with pEGFP-C1 and reconstructed vector.Episomal vectors from the stable monoclonal cell lines were extracted by modificated Hirt cracking protocol.Then CaCl2 method was performed to transform episomal vectors into the host bacteria E.coli DH5α,and the plasmid from the transformed E.coli DH5α was extracted.In the end,enzyme digestion identification and sequencing analysis were performed to detect the rescued plasmid and the original plasmid.Results Both double enzyme and single enzyme to completely digested the rescued plasmids and the original plassmid showed the same result.The sequencing analysis showed that the inserted sequence of rescued plasmid was identical to the original DNA sequence.Conclusion Human β-globin MAR characteristic sequence-based vector can be completely rescued from cultured CHO cells.The results of enzyme digestion identification and sequencing analysis are consistent in the rescued plasmids and the original plasmid.

  5. H2: entanglement, probability density function, confined Kratzer oscillator, universal potential and Mexican hat- or bell-type potential energy curves

    Van Hooydonk, Guido

    2011-01-01

    We review harmonic oscillator theory for closed, stable quantum systems. The H2 potential energy curve (PEC) of Mexican hat-type, calculated with a confined Kratzer oscillator, is better than the Rydberg-Klein-Rees (RKR) H2 PEC. Compared with QM, the theory of chemical bonding is simplified, since a confined Kratzer oscillator gives the long sought for universal function, once called the Holy Grail of Molecular Spectroscopy. This is validated with HF, I2, N2 and O2 PECs. We quantify the entan...

  6. H2: entanglement, probability density function, confined Kratzer oscillator, universal potential and (Mexican hat- or bell-type) potential energy curves

    Van Hooydonk, G.

    2011-01-01

    We review harmonic oscillator theory for closed, stable quantum systems. The H2 potential energy curve (PEC) of Mexican hat-type, calculated with a confined Kratzer oscillator, is better than the Rydberg-Klein-Rees (RKR) H2 PEC. Compared with QM, the theory of chemical bonding is simplified, since a confined Kratzer oscillator gives the long sought for universal function, once called the Holy Grail of Molecular Spectroscopy. This is validated with HF, I2, N2 and O2 PECs. We quantify the entan...

  7. Edebi Tür Olarak Mektup, Hatıra ve Günlüklere Yansıyanlar : Çanakkale’de Savaşan Askerlerin Mektup Hatıra ve Günlüklerinde Yer Alan Motivasyon Unsurları

    Altunyay, Korhan

    2014-01-01

    Edebiyat bilimi mektup, hatıra ve günlük gibi edebi türleri hem edebi tür olarak hem de araştırma kaynağı olarak kullanır. Bu türler/kaynaklar, aynı zamanda psikolojik araştırmalarda da kullanılır. Mektup, hatıra veya günlük gibi edebi türler, onu yazanın bilinçaltını görmek, hayata, olaylara ve problemlere ne tür açılardan baktığını fark etmek için kullanılır. Mektup, günlük ve hatıralara davranış-tepki ilişkisi açısından bakıldığı vakit pek çok detaya rastlanabilir. Bu çalışmada...

  8. HAT-P-49b: a 1.7 M J planet transiting a bright 1.5 M ☉ F-star

    We report the discovery of the transiting extrasolar planet HAT-P-49b. The planet transits the bright (V = 10.3) slightly evolved F-star HD 340099 with a mass of 1.54 M ☉ and a radius of 1.83 R ☉. HAT-P-49b is orbiting one of the 25 brightest stars to host a transiting planet which makes this a favorable candidate for detailed follow-up. This system is an especially strong target for Rossiter-McLaughlin follow-up due to the host star's fast rotation, 16 km s–1. The planetary companion has a period of 2.6915 days, mass of 1.73 M J, and radius of 1.41 R J. The planetary characteristics are consistent with that of a classical hot Jupiter but we note that this is the fourth most massive star to host a transiting planet with both Mp and Rp well determined.

  9. Améliorer le fonctionnement sans disque de la distribution Red Hat grâce à la fusion de système de fichiers

    Schweitzer, Pierre; Brarda, Loïc

    2011-01-01

    Le travail durant ce stage a permis de revoir, toute la gestion de la ferme de calcul sans disques qu'utilise l'expérience LHCb du CERN. Celle-ci est maintenant administrable par l'intermédiaire du logiciel de gestion Quattor et autorise à la fois l'administration du High Level Trigger (HLT) mais également du trigger L0 (contrairement à ce qui était initialement prévu). Cette nouvelle gestion, fortement indépendante des versions du système Linux utilisé, Scientific Linux CERN (SLC), permet le passage des CCPCs de SLC4 à SLC5 très facilement. Un résultat important est l'absence d'utilisation des outils Red Hat pour administer cette ferme, ce qui ouvre la voie à une future migration de l'ensemble de la ferme à SLC6, quand celle-ci sera prête. L'abandon des outils Red Hat a nécessité l'utilisation de la fusion de systèmes de fichiers pour assurer l'unicité d'un répertoire racine partagé par plusieurs machines. Jusqu'alors la fusion de systèmes de fichiers n'était pas utilisée, et seuls ...

  10. KEPLER'S OPTICAL SECONDARY ECLIPSE OF HAT-P-7b AND PROBABLE DETECTION OF PLANET-INDUCED STELLAR GRAVITY DARKENING

    Morris, Brett M.; Deming, Drake [Department of Astronomy, University of Maryland, College Park, MD 20742 (United States); Mandell, Avi M. [Goddard Center for Astrobiology, NASA' s Goddard Space Flight Center, Greenbelt, MD 20771 (United States)

    2013-02-20

    We present observations spanning 355 orbital phases of HAT-P-7 observed by Kepler from 2009 May to 2011 March (Q1-9). We find a shallower secondary eclipse depth than initially announced, consistent with a low optical albedo and detection of nearly exclusively thermal emission, without a reflected light component. We find an approximately 10 ppm perturbation to the average transit light curve near phase -0.02 that we attribute to a temperature decrease on the surface of the star, phased to the orbit of the planet. This cooler spot is consistent with planet-induced gravity darkening, slightly lagging the sub-planet position due to the finite response time of the stellar atmosphere. The brightness temperature of HAT-P-7b in the Kepler bandpass is T{sub B} = 2733 {+-} 21 K and the amplitude of the deviation in stellar surface temperature due to gravity darkening is approximately -0.18 K. The detection of the spot is not statistically unequivocal due its small amplitude, though additional Kepler observations should be able to verify the astrophysical nature of the anomaly.

  11. Evaluation of the relative precision of space-geodetic techniques at ITRF co-located sites with the Three Corner Hat approach

    Abbondanza, C.; Chin, T. M.; Gross, R. S.; Heflin, M. B.; Wu, X.

    2012-04-01

    The International Terrestrial Reference Frame (ITRF) is a linear reference frame consisting of regularized positions and velocities for a set of global stations. It relies on the combination of station positions, velocities and Earth orientation parameters (EOPs) acquired by GPS, VLBI, SLR and DORIS at co-located sites. To properly combine the individual reference frames and suitably scale the variance-covariance information from the 4 space-geodetic solutions, an a-priori knowledge of the relative precisions of the four techniques is mandatory. In this study, focusing on the station position time series derived from GNSS, VLBI, SLR and DORIS at ITRF co-locations, we aim at assessing the relative uncertainty of the co-located space geodetic instruments contributing to ITRF. The investigation relies on the idea of pair-wise differencing station position time series of at least three co-located instruments in order to remove common geophysical signals. By computing the variances of the differenced time series, the relative precision of each time series can be recovered with the Three Corner Hat technique, under the assumption of absence of correlation between the noise processes of the different techniques. Results of the Three Corner Hat analysis of co-located station position time series will be presented.

  12. Influence of Pastoralists' Sociocultural Activities on Tsetse-Trypanosome-Cattle Reservoir Interface: The Risk of Human African Trypanosomiasis in North-Central Nigeria.

    Alhaji, N B; Kabir, J

    2016-06-01

    The study investigated socio-cultural characteristics of pastoralists that influenced on the tsetse-trypanosome-cattle reservoir interface thereby predisposing them to HAT in Niger State, North-central Nigeria. It was a cross-sectional survey of adult pastoral herders, aged 30 years and above, and conducted between October 2012 and February 2013. A face-to-face structured questionnaire was administered on the pastoralists nested in 96 cattle herds with questions focused on pastoralists' socio-cultural activities and behavioral practices related to HAT risk. Descriptive and analytic statistics were used to describe the obtained data. A total of 384 pastoralists participated, with mean age of 49.6  ± 10.76 SD years. Male respondents constituted 86.7% of gender, while pastoralists of age group 40-49 years constituted 35.4% of respondents. About 59.4% of the pastoralists had knowledge about HAT and its symptoms and only 33.9% of them believed that cattle served as reservoir of HAT trypanosome. Knowledge/belief levels of the pastoralists about African trypanosomiasis occurrence in humans and animals were statistically significant. Males were four times more likely to be exposed to HAT (OR = 3.67; 95% CI: 1.42, 9.52); age group 60-69 was also four times more likely to be exposed (OR = 3.59; 95% CI: 1.56, 8.28); and nomadic pastoralists were two times more likely to be exposed to HAT (OR = 2.07; 95% CI: 1.37, 3.14). All cultural practices significantly influenced exposure to HAT with extensive husbandry system three times more likely to predisposed pastoralists to HAT (OR = 3.21; 95% CI: 1.65, 6.24). Socio-cultural characteristics of pastoralists influenced exposure to HAT risk and, therefore, there is a need to sensitize them to bring changes to their socio-cultural practices and perceptions to achieve effective and long term sustainable HAT control. Elimination strategies of parasites in animals and vectors should be considered to avoid reintroduction

  13. H2: entanglement, probability density function, confined Kratzer oscillator, universal potential and (Mexican hat- or bell-type) potential energy curves

    Van Hooydonk, G

    2011-01-01

    We review harmonic oscillator theory for closed, stable quantum systems. The H2 potential energy curve (PEC) of Mexican hat-type, calculated with a confined Kratzer oscillator, is better than the Rydberg-Klein-Rees (RKR) H2 PEC. Compared with QM, the theory of chemical bonding is simplified, since a confined Kratzer oscillator gives the long sought for universal function, once called the Holy Grail of Molecular Spectroscopy. This is validated with HF, I2, N2 and O2 PECs. We quantify the entanglement of spatially separated H2 quantum states, which gives a braid view. The equal probability for H2, originating either from HA+HB or HB+HA, is quantified with a Gauss probability density function. At the Bohr scale, confined harmonic oscillators behave properly at all extremes of bound two-nucleon quantum systems and are likely to be useful also at the nuclear scale.

  14. The Parameterization of Top-Hat Particle Sensors with Microchannel-Plate-Based Detection Systems and its Application to the Fast Plasma Investigation on NASA's Magnetospheric MultiScale Mission

    Gershman, Daniel J.; Gliese, Ulrik; Dorelli, John C.; Avanov, Levon A.; Barrie, Alexander C.; Chornay, Dennis J.; MacDonald, Elizabeth A.; Holland, Matthew P.; Pollock, Craig J.

    2015-01-01

    The most common instrument for low energy plasmas consists of a top-hat electrostatic analyzer geometry coupled with a microchannel-plate (MCP)-based detection system. While the electrostatic optics for such sensors are readily simulated and parameterized during the laboratory calibration process, the detection system is often less well characterized. Furthermore, due to finite resources, for large sensor suites such as the Fast Plasma Investigation (FPI) on NASA's Magnetospheric Multiscale (MMS) mission, calibration data are increasingly sparse. Measurements must be interpolated and extrapolated to understand instrument behavior for untestable operating modes and yet sensor inter-calibration is critical to mission success. To characterize instruments from a minimal set of parameters we have developed the first comprehensive mathematical description of both sensor electrostatic optics and particle detection systems. We include effects of MCP efficiency, gain, scattering, capacitive crosstalk, and charge cloud spreading at the detector output. Our parameterization enables the interpolation and extrapolation of instrument response to all relevant particle energies, detector high voltage settings, and polar angles from a small set of calibration data. We apply this model to the 32 sensor heads in the Dual Electron Sensor (DES) and 32 sensor heads in the Dual Ion Sensor (DIS) instruments on the 4 MMS observatories and use least squares fitting of calibration data to extract all key instrument parameters. Parameters that will evolve in flight, namely MCP gain, will be determined daily through application of this model to specifically tailored in-flight calibration activities, providing a robust characterization of sensor suite performance throughout mission lifetime. Beyond FPI, our model provides a valuable framework for the simulation and evaluation of future detection system designs and can be used to maximize instrument understanding with minimal calibration

  15. Uncertainties of the Gravity Recovery and Climate Experiment time-variable gravity-field solutions based on three-cornered hat method

    Ferreira, Vagner G.; Montecino, Henry D. C.; Yakubu, Caleb I.; Heck, Bernhard

    2016-01-01

    Currently, various satellite processing centers produce extensive data, with different solutions of the same field being available. For instance, the Gravity Recovery and Climate Experiment (GRACE) has been monitoring terrestrial water storage (TWS) since April 2002, while the Center for Space Research (CSR), the Jet Propulsion Laboratory (JPL), the GeoForschungsZentrum (GFZ), and the Groupe de Recherche de Géodésie Spatiale (GRGS) provide individual monthly solutions in the form of Stokes coefficients. The inverted TWS maps (or the regionally averaged values) from these coefficients are being used in many applications; however, as no ground truth data exist, the uncertainties are unknown. Consequently, the purpose of this work is to assess the quality of each processing center by estimating their uncertainties using a generalized formulation of the three-cornered hat (TCH) method. Overall, the TCH results for the study period of August 2002 to June 2014 indicate that at a global scale, the CSR, GFZ, GRGS, and JPL presented uncertainties of 9.4, 13.7, 14.8, and 13.2 mm, respectively. At a basin scale, the overall good performance of the CSR was observed at 91 river basins. The TCH-based results were confirmed by a comparison with an ensemble solution from the four GRACE processing centers.

  16. Spitzer Secondary Eclipses of the Dense, Modestly-irradiated, Giant Exoplanet HAT-P-20b Using Pixel-Level Decorrelation

    Deming, Drake; Kammer, Joshua; Fulton, Benjamin J; Ingalls, James; Carey, Sean; Burrows, Adam; Fortney, Jonathan J; Todorov, Kamen; Agol, Eric; Cowan, Nicolas; Desert, Jean-Michel; Fraine, Jonathan; Langton, Jonathan; Morley, Caroline; Showman, Adam P

    2014-01-01

    HAT-P-20b is a giant exoplanet that orbits a metal-rich star. The planet itself has a high total density, suggesting that it may also have a high metallicity in its atmosphere. We analyze two eclipses of the planet in each of the 3.6- and 4.5 micron bands of Warm Spitzer. These data exhibit intra-pixel detector sensitivity fluctuations that were resistant to traditional decorrelation methods. We have developed a simple, powerful, and radically different method to correct the intra-pixel effect for Warm Spitzer data, which we call pixel-level decorrelation (PLD). PLD corrects the intra-pixel effect very effectively, but without explicitly using - or even measuring - the fluctuations in the apparent position of the stellar image. We illustrate and validate PLD using synthetic and real data, and comparing the results to previous analyses. PLD can significantly reduce or eliminate red noise in Spitzer secondary eclipse photometry, even for eclipses that have proven to be intractable using other methods. Our succe...

  17. Broad-band spectrophotometry of the hot Jupiter HAT-P-12b from the near-UV to the near-IR

    Mallonn, M; Weingrill, J; von Essen, C; Strassmeier, K G; Piotto, G; Pagano, I; Scandariato, G; Csizmadia, Sz; Herrero, E; Sada, P V; Dhillon, V S; Marsh, T R; Künstler, A; Bernt, I; Granzer, T

    2015-01-01

    The detection of trends or gradients in the transmission spectrum of extrasolar planets is possible with observations at very low spectral resolution. Transit measurements of sufficient accuracy using selected broad-band filters allow for an initial characterization of the atmosphere of the planet. We obtained time series photometry of 20 transit events and analyzed them homogeneously, along with eight light curves obtained from the literature. In total, the light curves span a range from 0.35 to 1.25 microns. During two observing seasons over four months each, we monitored the host star to constrain the potential influence of starspots on the derived transit parameters. We rule out the presence of a Rayleigh slope extending over the entire optical wavelength range, a flat spectrum is favored for HAT-P-12b with respect to a cloud-free atmosphere model spectrum. A potential cause of such gray absorption is the presence of a cloud layer at the probed latitudes. Furthermore, in this work we refine the transit pa...

  18. Demonstrating High-precision, Multi-band Transit Photometry with MuSCAT: A Case for HAT-P-14b

    Fukui, Akihiko; Kawashima, Yui; Kusakabe, Nobuhiko; Onitsuka, Masahiro; Ryu, Tsuguru; Ikoma, Masahiro; Yanagisawa, Kenshi; Izumiura, Hideyuki

    2015-01-01

    The Multicolor Simultaneous Camera for studying Atmospheres of Transiting exoplanets (MuSCAT) is an optical three-band (g'_2-, r'_2-, and z_{s,2}-band) imager, recently developed for the 188cm telescope at Okayama Astrophysical Observatory with the aim of validating and characterizing transiting planets. In a pilot observation with MuSCAT, we observed a primary transit of HAT-P-14b, a high-surface gravity (g_p=38 ms^{-2}) hot Jupiter around a bright (V=10) F-type star. From a 2.9-hour observation, we achieve the 5-min binned photometric precisions of 0.028%, 0.022%, and 0.024% in the g'_2, r'_2, and z_{s,2} bands, respectively, providing the highest-quality photometric data for this planet. Combining these results with those of previous observations, we search for variations of transit timing and duration over five years, as well as variations of planet-star radius ratio (R_p/R_s) with wavelength, but find no considerable variation in any parameters. On the other hand, using the transit-subtracted light curve...

  19. Hubble Space Telescope hot Jupiter Transmission Spectral Survey: detection of water in HAT-P-1b from Wide Field Camera 3 near-infrared spatial scan observations

    Wakeford, H R; Deming, D; Gibson, N P; Fortney, J J; Burrows, A S; Ballester, G; Nikolov, N; Aigrain, S; Henry, G; Knutson, H; Etangs, A Lecavelier des; Pont, F; Showman, A P; Vidal-Madjar, A; Zahnle, K

    2013-01-01

    We present Hubble Space Telescope near-infrared transmission spectroscopy of the transiting hot-Jupiter HAT-P-1b. We observed one transit with Wide Field Camera 3 using the G141 low-resolution grism to cover the wavelength range 1.087- 1.678 {\\mu}m. These time series observations were taken with the newly available spatial scan mode that increases the duty cycle by nearly a factor of two, thus improving the resulting photometric precision of the data. We measure a planet-to-star radius ratio of Rp/R*=0.11709+/-0.00038 in the white light curve with the centre of transit occurring at 2456114.345+/-0.000133 (JD). We achieve S/N levels per exposure of 1840 (0.061%) at a resolution of {\\Delta\\lambda}=19.2nm (R~70) in the 1.1173 - 1.6549{\\mu}m spectral region, providing the precision necessary to probe the transmission spectrum of the planet at close to the resolution limit of the instrument. We compute the transmission spectrum using both single target and differential photometry with similar results. The resultan...

  20. The optical transmission spectrum of the hot Jupiter HAT-P-32b: clouds explain the absence of broad spectral features?

    Gibson, N P; Barstow, J K; Evans, T M; Fletcher, L N; Irwin, P G J

    2013-01-01

    We report Gemini-North GMOS observations of the inflated hot Jupiter HAT-P-32b during two primary transits. We simultaneously observed two comparison stars and used differential spectro-photometry to produce multi-wavelength light curves. 'White' light curves and 29 'spectral' light curves were extracted for each transit and analysed to refine the system parameters and produce transmission spectra from 520-930nm in ~14nm bins. The light curves contain time-varying white noise as well as time-correlated noise, and we used a Gaussian process model to fit this complex noise model. Common mode corrections derived from the white light curve fits were applied to the spectral light curves which significantly improved our precision, reaching typical uncertainties in the transit depth of ~2x10^-4, corresponding to about half a pressure scale height. The low resolution transmission spectra are consistent with a featureless model, and we can confidently rule out broad features larger than about one scale height. The abs...

  1. Genetically modified pigs produced with a nonviral episomal vector

    Manzini, Stefano; Vargiolu, Alessia; Stehle, Isa M; Bacci, Maria Laura; Cerrito, Maria Grazia; Giovannoni, Roberto; Zannoni, Augusta; Bianco, Maria Rosaria; Forni, Monica; Donini, Pierluigi; Papa, Michele; Lipps, Hans J; Lavitrano, Marialuisa

    2006-01-01

    Genetic modification of cells and animals is an invaluable tool for biotechnology and biomedicine. Currently, integrating vectors are used for this purpose. These vectors, however, may lead to insertional mutagenesis and variable transgene expression and can undergo silencing. Scaffold/matrix attachment region-based vectors are nonviral expression systems that replicate autonomously in mammalian cells, thereby making possible safe and reliable genetic modification of higher eukaryotic cells a...

  2. Long-term denudation rates from the Central Andes (Chile) estimated from a digital elevation model using the black top hat function and inverse distance weighting : implications for the neogene climate of the Atacama Desert

    Riquelme, R.; Darrozes, J; Maire, E.; Hérail, Gérard; J. C. Soula

    2008-01-01

    A methodology for determining long-term denudation rates from morphologic markers in a Digital Elevation Model (DEM) is checked by a comparative study of two drainage basins in the Precordillera of the Central Andes. In both cases the initial configuration of an incised pediment surface has been restored by using two different methods: the Black Top Hat (BTH) function and the Inverse Distance Weighting (IDW) interpolation. Where vertical incision and hillslope erosion are recorded, the 1DW ap...

  3. 3.6 and 4.5 $\\mu$m ${\\it Spitzer}$ Phase Curves of the Highly-Irradiated Hot Jupiters WASP-19b and HAT-P-7b

    Wong, Ian; Kataria, Tiffany; Lewis, Nikole K; Burrows, Adam; Fortney, Jonathan J; Schwartz, Joel; Shporer, Avi; Agol, Eric; Cowan, Nicholas B; Deming, Drake; Desert, Jean-Michel; Fulton, Benjamin J; Howard, Andrew W; Langton, Jonathan; Laughlin, Gregory; Showman, Adam P; Todorov, Kamen

    2016-01-01

    We analyze full-orbit phase curve observations of the transiting hot Jupiters WASP-19b and HAT-P-7b at 3.6 and 4.5 $\\mu$m obtained using the Spitzer Space Telescope. For WASP-19b, we measure secondary eclipse depths of $0.485\\%\\pm 0.024\\%$ and $0.584\\%\\pm 0.029\\%$ at 3.6 and 4.5 $\\mu$m, which are consistent with a single blackbody with effective temperature $2372 \\pm 60$ K. The measured 3.6 and 4.5 $\\mu$m secondary eclipse depths for HAT-P-7b are $0.156\\%\\pm 0.009\\%$ and $0.190\\%\\pm 0.006\\%$, which are well-described by a single blackbody with effective temperature $2667\\pm 57$ K. Comparing the phase curves to the predictions of one-dimensional and three-dimensional atmospheric models, we find that WASP-19b's dayside emission is consistent with a model atmosphere with no dayside thermal inversion and moderately efficient day-night circulation. We also detect an eastward-shifted hotspot, suggesting the presence of a superrotating equatorial jet. In contrast, HAT-P-7b's dayside emission suggests a dayside therm...

  4. Time-resolved luminescence biosensor for continuous activity detection of protein acetylation-related enzymes based on DNA-sensitized terbium(III) probes.

    Han, Yitao; Li, Hao; Hu, Yufang; Li, Pei; Wang, Huixia; Nie, Zhou; Yao, Shouzhuo

    2015-09-15

    Protein acetylation of histone is an essential post-translational modification (PTM) mechanism in epigenetic gene regulation, and its status is reversibly controlled by histone acetyltransferases (HATs) and histone deacetylases (HDACs). Herein, we have developed a sensitive and label-free time-resolved luminescence (TRL) biosensor for continuous detection of enzymatic activity of HATs and HDACs, respectively, based on acetylation-mediated peptide/DNA interaction and Tb(3+)/DNA luminescent probes. Using guanine (G)-rich DNA-sensitized Tb(3+) luminescence as the output signal, the polycationic substrate peptides interact with DNA with high affinity and subsequently replace Tb(3+), eliminating the luminescent signal. HAT-catalyzed acetylation remarkably reduces the positive charge of the peptides and diminishes the peptide/DNA interaction, resulting in the signal on detection via recovery of DNA-sensitized Tb(3+) luminescence. With this TRL sensor, HAT (p300) can be sensitively detected with a wide linear range from 0.2 to 100 nM and a low detection limit of 0.05 nM. The proposed sensor was further used to continuously monitor the HAT activity in real time. Additionally, the TRL biosensor was successfully applied to evaluating HAT inhibition by two specific inhibitors, anacardic acid and C464, and satisfactory Z'-factors above 0.73 were obtained. Moreover, this sensor is feasible to continuously monitor the HDAC (Sirt1)-catalyzed deacetylation with a linear range from 0.5 to 500 nM and a detection limit of 0.5 nM. The proposed sensor is a convenient, sensitive, and mix-and-read assay, presenting a promising platform for protein acetylation-targeted epigenetic research and drug discovery. PMID:26307596

  5. Activities.

    Moody, Mally

    1992-01-01

    A series of four activities are presented to enhance students' abilities to appreciate and use trigonometry as a tool in problem solving. Activities cover problems applying the law of sines, the law of cosines, and matching equivalent trigonometric expressions. A teacher's guide, worksheets, and answers are provided. (MDH)

  6. Phenolic Constituents of Medicinal Plants with Activity against Trypanosoma brucei.

    Sun, Ya Nan; No, Joo Hwan; Lee, Ga Young; Li, Wei; Yang, Seo Young; Yang, Gyongseon; Schmidt, Thomas J; Kang, Jong Seong; Kim, Young Ho

    2016-01-01

    Neglected tropical diseases (NTDs) affect over one billion people all over the world. These diseases are classified as neglected because they impact populations in areas with poor financial conditions and hence do not attract sufficient research investment. Human African Trypanosomiasis (HAT or sleeping sickness), caused by the parasite Trypanosoma brucei, is one of the NTDs. The current therapeutic interventions for T. brucei infections often have toxic side effects or require hospitalization so that they are not available in the rural environments where HAT occurs. Furthermore, parasite resistance is increasing, so that there is an urgent need to identify novel lead compounds against this infection. Recognizing the wide structural diversity of natural products, we desired to explore and identify novel antitrypanosomal chemotypes from a collection of natural products obtained from plants. In this study, 440 pure compounds from various medicinal plants were tested against T. brucei by in a screening using whole cell in vitro assays. As the result, twenty-two phenolic compounds exhibited potent activity against cultures of T. brucei. Among them, eight compounds-4, 7, 11, 14, 15, 18, 20, and 21-showed inhibitory activity against T. brucei, with IC50 values below 5 µM, ranging from 0.52 to 4.70 μM. Based on these results, we attempt to establish some general trends with respect to structure-activity relationships, which indicate that further investigation and optimization of these derivatives might enable the preparation of potentially useful compounds for treating HAT. PMID:27077842

  7. Phenolic Constituents of Medicinal Plants with Activity against Trypanosoma brucei

    Ya Nan Sun

    2016-04-01

    Full Text Available Neglected tropical diseases (NTDs affect over one billion people all over the world. These diseases are classified as neglected because they impact populations in areas with poor financial conditions and hence do not attract sufficient research investment. Human African Trypanosomiasis (HAT or sleeping sickness, caused by the parasite Trypanosoma brucei, is one of the NTDs. The current therapeutic interventions for T. brucei infections often have toxic side effects or require hospitalization so that they are not available in the rural environments where HAT occurs. Furthermore, parasite resistance is increasing, so that there is an urgent need to identify novel lead compounds against this infection. Recognizing the wide structural diversity of natural products, we desired to explore and identify novel antitrypanosomal chemotypes from a collection of natural products obtained from plants. In this study, 440 pure compounds from various medicinal plants were tested against T. brucei by in a screening using whole cell in vitro assays. As the result, twenty-two phenolic compounds exhibited potent activity against cultures of T. brucei. Among them, eight compounds—4, 7, 11, 14, 15, 18, 20, and 21—showed inhibitory activity against T. brucei, with IC50 values below 5 µM, ranging from 0.52 to 4.70 μM. Based on these results, we attempt to establish some general trends with respect to structure-activity relationships, which indicate that further investigation and optimization of these derivatives might enable the preparation of potentially useful compounds for treating HAT.

  8. THE EVIL-MC MODEL FOR ELLIPSOIDAL VARIATIONS OF PLANET-HOSTING STARS AND APPLICATIONS TO THE HAT-P-7 SYSTEM

    We present a new model for Ellipsoidal Variations Induced by a Low-Mass Companion, the EVIL-MC model. We employ several approximations appropriate for planetary systems to substantially increase the computational efficiency of our model relative to more general ellipsoidal variation models and improve upon the accuracy of simpler models. This new approach gives us a unique ability to rapidly and accurately determine planetary system parameters. We use the EVIL-MC model to analyze Kepler Quarter 0-2 (Q0-2) observations of the HAT-P-7 system, an F-type star orbited by a ∼ Jupiter-mass companion. Our analysis corroborates previous estimates of the planet-star mass ratio q = (1.10 ± 0.06) × 10–3, and we have revised the planet's dayside brightness temperature to 2680+10–20 K. We also find a large difference between the day- and nightside planetary flux, with little nightside emission. Preliminary dynamical+radiative modeling of the atmosphere indicates that this result is qualitatively consistent with high altitude absorption of stellar heating. Similar analyses of Kepler and CoRoT photometry of other planets using EVIL-MC will play a key role in providing constraints on the properties of many extrasolar systems, especially given the limited resources for follow-up and characterization of these systems. However, as we highlight, there are important degeneracies between the contributions from ellipsoidal variations and planetary emission and reflection. Consequently, for many of the hottest and brightest Kepler and CoRoT planets, accurate estimates of the planetary emission and reflection, diagnostic of atmospheric heat budgets, will require accurate modeling of the photometric contribution from the stellar ellipsoidal variation.

  9. MRG15 activates the cdc2 promoter via histone acetylation in human cells

    Chromatin remodeling is required for transcriptional activation and repression. MRG15 (MORF4L1), a chromatin modulator, is a highly conserved protein and is present in complexes containing histone acetyltransferases (HATs) as well as histone deacetylases (HDACs). Loss of expression of MRG15 in mice and Drosophila results in embryonic lethality and fibroblast and neural stem/progenitor cells cultured from Mrg15 null mouse embryos exhibit marked proliferative defects when compared with wild type cells. To determine the role of MRG15 in cell cycle progression we performed chromatin immunoprecipitation with an antibody to MRG15 on normal human fibroblasts as they entered the cell cycle from a quiescent state, and analyzed various cell cycle gene promoters. The results demonstrated a 3-fold increase in MRG15 occupancy at the cdc2 promoter during S phase of the cell cycle and a concomitant increase in acetylated histone H4. H4 lysine 12 was acetylated at 24 h post-serum stimulation while there was no change in acetylation of lysine 16. HDAC1 and 2 were decreased at this promoter during cell cycle progression. Over-expression of MRG15 in HeLa cells activated a cdc2 promoter-reporter construct in a dose-dependent manner, whereas knockdown of MRG15 resulted in decreased promoter activity. In order to implicate HAT activity, we treated cells with the HAT inhibitor anacardic acid and determined that HAT inhibition results in loss of expression of cdc2 mRNA. Further, chromatin immunoprecipitation with Tip60 localizes the protein to the same 110 bp stretch of the cdc2 promoter pulled down by MRG15. Additionally, we determined that cotransfection of MRG15 with the known associated HAT Tip60 had a cooperative effect in activating the cdc2 promoter. These results suggest that MRG15 is acting in a HAT complex involving Tip60 to modify chromatin via acetylation of histone H4 at the cdc2 promoter to activate transcription.

  10. THE TRADE TIES HAT BIND

    MATT; YOUNG

    2006-01-01

    Chinese President Hu Jintao made his first state visit to the United States April 19-21. The president kicked off his tour in Seattle, where he had intense contact with the American business community as represented by Boeing and Microsoft. Hu then landed in Washington D.C. for a summit meeting with President George W. Bush, followed by a visit to Yale University. During the meeting with Bush, Hu conveyed the idea that China and the United States are "not only stakeholders, but also constructive partners...

  11. Welches Geschlecht hat die Avantgarde?

    Gertrud Lehnert

    2000-07-01

    Full Text Available Das Buch betrachtet das Theater der französischen und amerikanischen ‚Avantgarde‘ der Moderne und Postmoderne unter dem Aspekt des Geschlechts: Welcher Verfahren bedient sich avantgardistische Kunst, ist avantgardistische Kunst in geschlechtlicher Hinsicht restriktiv, oder ermöglicht sie die subversive feministische oder auch lesbisch-schwule Ausformung spezifischer Formen?

  12. hatü’l-İnsân (Pend-Nâme-i Enûşîrvân’ın Türkçe Bir Tercümesi A Turkish Translation of Râhatü’l-İnsân (Pend-Nâme-i Enûşîrvân

    Müjgân ÇAKIR

    2012-09-01

    Full Text Available Islamic literatures include many texts on the justice and counsels of Sassanian ruler Nûşîrevân. One of these is a work of Persian Literature which recounts the counsels written on his crown and figures with the titles of “Râhatü’l-insân” or “Pend-nâme-i Enûşîrvân” in some sources. Rıza Kulı Han Hidayet states that the text belongs to Bedâyi‛-i Belhî; however the identity of the author is disputed. It is also argued that the “Şerîf-i Şair,” whose name appears in the introduction to the text edited by Charles Schefer in his work entitled Chrestomathie Persane, is Ebû Şerîf Muhalledi-yi Gurgânî. Râhatü’l-insân has manuscripts in Turkish libraries. This article treats this work and its Turkish prose translation located at Süleymaniye Library, Fatih Section No. 5385 under the title “Pend-i Nûşîrevân-ı Âdil.” In this translation, the counsels written on the seventeen slices (küngüre of Nûşîrevân’s crown are given and it is told that this ruler had his crown put up somewhere appropriate every year for the soldiers to read his counsels. The purposes of Nûşîrevân’s counsels are proving a moral education to the public, directing his relations with his people as well as organizing the relations between them. Some of the counsels written on Nûşîrevân’s crown are as follows: “Respect the old and the weak, observe the rights of your parents, consult scholars before you do your business, have a command of your speech, do not betray trust, think before you speak.” The article will also treat some of the differences between the Persian manuscripts of the work and its Turkish translation. The transcription of the Turkish translation will be given. İslâmî edebiyatlarda Sasani hükümdarı Nûşîrevân’ın adaleti ve nasihatlarıyla ilgili birçok metin yazılmıştır. Bu metinlerden biri Fars Edebiyatı’nda onun tacının üzerinde yazılı olan nasihatları anlatan ve baz

  13. Tarih Algısı Bağlamında Postmodern Bir Anlatı: İstanbul Hatırası A Postmodern Narration in the Context of History Perception: İstanbul Hatırası

    Mustafa AYDEMİR

    2012-09-01

    Full Text Available Detective novel, formed around an intelligently planned murder and a detective who tries to solve it and find the murderer, shows a significant improvement with the influence of Postmodernism, which rose in the second half of 20th Century. That improvement first shows its face in translation, then writing in Turkish Literature. The history of detective novel, which began to take its place inliterary history due to the emergence of crime and along withurbanization, is as old as the concept of crime history. Having aparticular history, it can be claimed that it prepared the ground for theemergence of novel. However, two major war, which happened in the20th century, has led to a rapid development of the detective novel, thebest way to tell the story of the crimes.Ahmet Ümit’s novel İstanbul Hatırası is important as it shows thechange of detective novel in Turkish novel. A real – up to date and anunreal – historical, two different engaging fictions are being narrated inthat detective novel. Beginning with the murder, a journey to thehistorical sites of Istanbul is made. In addition, the importances ofthese sites, which are close to be destroyed, are pointed out.In this study, after mentioning how detective novel emerged inWest and Turkish Literature and its historic development, Ahmet Ümit’sİstanbul Hatırası has been analyzed and postmodern features in thisnovel has been emphasized. With this method, postmoderncharacteristics of the novel has been taken care in terms of plot, time,place, characters and the classical elements of the novel has beenevaluated with a postmodernist approach. Zekice plânlanmış bir cinayet ve onu çözmeye, katili bulmaya çalışan bir dedektif etrafında şekillenen polisiye roman, 20. yüzyılın ikinci yarısında ortaya çıkan postmodernizmin de etkisiyle önemli bir gelişme gösterir. Bu gelişme, Türk edebiyatında önce çeviri, sonra da telif yoluyla kendini gösterir. Suçun ortaya

  14. Yaşar Şadi Efendi’nin “Hutut-ı Meşahir” İsimli Hatıra Defteri ve Muhtevası

    Berk, Süleyman

    2015-01-01

    “Hutût-ı Meşâhir” mecmuaları bir nevi hatıra defterlerini andıran çalışmalardır. Hatıra defterlerinden farkı, çok çeşitli kimselerin, kendilerine sunulan deftere, el yazıları ile o an akla gelenleri, şiirleri, özlü sözleri yazmaları veya maharetlerini aktarmalarıdır. Şimdiye kadar ancak baskılarını görebildiğimiz bazı hutût-ı meşâhir mecmuaları içerisinde en kapsamlı olanı Yaşar Şâdi’nin hazırladığı sözünü ettiğimiz mecmua gibi görülüyor. Yaşar Şâdi, 1336/1920 ile 1338/1923 yıl...

  15. A Three Corner Hat-based analysis of station position time series for the assessment of inter-technique precision at ITRF co-located sites

    Abbondanza, C.; Chin, T. M.; Gross, R. S.; Heflin, M. B.; Hurst, K. J.; Parker, J. W.; Wu, X.; Altamimi, Z.

    2012-12-01

    Assessing the uncertainty in geodetic positioning is a crucial factor when combining independent space-geodetic solutions for the computation of the International Terrestrial Reference Frame (ITRF). ITRF is a combined product based on the stacking of VLBI, GPS, SLR and DORIS solutions and merging the single technique reference frames with terrestrial local tie measurements at co-located sites. In current ITRF realizations, the uncertainty evaluation of the four techniques relies on the analysis of the post-fit residuals, which are a by-product of the combination process. An alternative approach to the assessment of the inter-technique precision can be offered by a Three Corner Hat (TCH) analysis of the non-linear residual time series obtained at ITRF co-location sites as a by-product of the stacking procedure. Non-linear residuals of station position time series stemming from global networks of the four techniques can be modeled as a composition of periodic signals (commonly annual and semi-annual) and stochastic noise, typically characterized as a combination of flicker and white noise. Pair-wise differences of station position time series of at least three co-located instruments can be formed with the aim of removing the common geophysical signal and characterizing the inter-technique precision. The application of TCH relies on the hypothesis of absence of correlation between the error processes of the four techniques and assumes the stochastic noise to be Gaussian. If the hypothesis of statistical independence between the space-geodetic technique errors is amply verified, the assumption of pure white noise of the stochastic error processes appears to be more questionable. In fact, previous studies focused on geodetic positioning consistently showed that flicker noise generally prevails over white noise in the analysis of global network GPS time series, whereas in VLBI, SLR and DORIS time series Gaussian noise is predominant. In this investigation, TCH is applied

  16. Regulation of the histone acetyltransferase activity of hMOF via autoacetylation of Lys274

    Bingfa Sun; Shunling Guo; Qingyu Tang; Chen Li; Rong Zeng; Zhiqi Xiong; Chen Zhong; Jianping Ding

    2011-01-01

    Dear Editor, Males-absent-on-the-first (MOF, also called MYST1 or KAT8) is a histone acetyltransferase (HAT) belonging to the MOZ, Ybf2/Sas3, Sas2 and Tip60 (MYST) family.MOF has been shown to possess a specific HAT activity towards Lysl6 of histone H4 (H4K16) [1].Homozygous knockout of MOF in mice results in loss of H4K16 acetylation and embryonic lethality, indicating that MOF and H4K16 acetylation are essential for embryogenesis and genome stability in mammals [2].Downregulation of human MOF (hMOF) leads to dramatic nuclear morphological deformation and inhibition of cell cycle progression [3], and has recently been correlated with primary breast carcinoma and medulloblastoma [4].

  17. Human T-cell leukemia virus type-1-encoded protein HBZ represses p53 function by inhibiting the acetyltransferase activity of p300/CBP and HBO1

    Hoang, Kimson; Ankney, John A.; Nguyen, Stephanie T.; Rushing, Amanda W.; Polakowski, Nicholas; Miotto, Benoit; Lemasson, Isabelle

    2016-01-01

    Adult T-cell leukemia (ATL) is an often fatal malignancy caused by infection with the complex retrovirus, human T-cell Leukemia Virus, type 1 (HTLV-1). In ATL patient samples, the tumor suppressor, p53, is infrequently mutated; however, it has been shown to be inactivated by the viral protein, Tax. Here, we show that another HTLV-1 protein, HBZ, represses p53 activity. In HCT116 p53+/+ cells treated with the DNA-damaging agent, etoposide, HBZ reduced p53-mediated activation of p21/CDKN1A and GADD45A expression, which was associated with a delay in G2 phase-arrest. These effects were attributed to direct inhibition of the histone acetyltransferase (HAT) activity of p300/CBP by HBZ, causing a reduction in p53 acetylation, which has be linked to decreased p53 activity. In addition, HBZ bound to, and inhibited the HAT activity of HBO1. Although HBO1 did not acetylate p53, it acted as a coactivator for p53 at the p21/CDKN1A promoter. Therefore, through interactions with two separate HAT proteins, HBZ impairs the ability of p53 to activate transcription. This mechanism may explain how p53 activity is restricted in ATL cells that do not express Tax due to modifications of the HTLV-1 provirus, which accounts for a majority of patient samples. PMID:26625199

  18. Hatékony leadership magatartások szlovák szervezeti környezetben (Effective leadership behaviors in Slovak organizational environment – Introduction to the Slovak implict leadership theories –Results of the GLOBE research)

    Bauer, Dávid

    2014-01-01

    Az itt bemutatott kutatás célja az volt, hogy azonosítsa és feltárja a szlovák vállalati környezetben követett és kívánatosnak tartott leadership dimenziókat és bemutassa azokat az implicit leadership elmélet alapján meghatározott magatartásokat, amelyek a sikeres leadershipet támogató magatartásokként jelennek meg (az implicit leadership elmélet szerint az egyének magatartásokhoz kapcsolódó hiedelmeik, meggyőződéseik és értékítéleteik alapján határozzák meg, kit tekintenek vezető...

  19. The cellular bromodomain protein Brd4 has multiple functions in E2-mediated papillomavirus transcription activation.

    Helfer, Christine M; Yan, Junpeng; You, Jianxin

    2014-08-01

    The cellular bromodomain protein Brd4 functions in multiple processes of the papillomavirus life cycle, including viral replication, genome maintenance, and gene transcription through its interaction with the viral protein, E2. However, the mechanisms by which E2 and Brd4 activate viral transcription are still not completely understood. In this study, we show that recruitment of positive transcription elongation factor b (P-TEFb), a functional interaction partner of Brd4 in transcription activation, is important for E2's transcription activation activity. Furthermore, chromatin immunoprecipitation (ChIP) analyses demonstrate that P-TEFb is recruited to the actual papillomavirus episomes. We also show that E2's interaction with cellular chromatin through Brd4 correlates with its papillomavirus transcription activation function since JQ1(+), a bromodomain inhibitor that efficiently dissociates E2-Brd4 complexes from chromatin, potently reduces papillomavirus transcription. Our study identifies a specific function of Brd4 in papillomavirus gene transcription and highlights the potential use of bromodomain inhibitors as a method to disrupt the human papillomavirus (HPV) life cycle. PMID:25140737

  20. The Cellular Bromodomain Protein Brd4 has Multiple Functions in E2-Mediated Papillomavirus Transcription Activation

    Christine M. Helfer

    2014-08-01

    Full Text Available The cellular bromodomain protein Brd4 functions in multiple processes of the papillomavirus life cycle, including viral replication, genome maintenance, and gene transcription through its interaction with the viral protein, E2. However, the mechanisms by which E2 and Brd4 activate viral transcription are still not completely understood. In this study, we show that recruitment of positive transcription elongation factor b (P-TEFb, a functional interaction partner of Brd4 in transcription activation, is important for E2’s transcription activation activity. Furthermore, chromatin immunoprecipitation (ChIP analyses demonstrate that P-TEFb is recruited to the actual papillomavirus episomes. We also show that E2’s interaction with cellular chromatin through Brd4 correlates with its papillomavirus transcription activation function since JQ1(+, a bromodomain inhibitor that efficiently dissociates E2-Brd4 complexes from chromatin, potently reduces papillomavirus transcription. Our study identifies a specific function of Brd4 in papillomavirus gene transcription and highlights the potential use of bromodomain inhibitors as a method to disrupt the human papillomavirus (HPV life cycle.

  1. HBO1 histone acetylase activity is essential for DNA replication licensing and inhibited by geminin

    Miotto, Benoit; Struhl, Kevin

    2010-01-01

    HBO1, an H4-specific histone acetylase, is a co-activator of the DNA replication licensing factor Cdt1. HBO1 acetylase activity is required for licensing, because a HAT-defective mutant of HBO1 bound at origins is unable to load the MCM complex. H4 acetylation at origins is cell-cycle regulated, with maximal activity at the G1/S transition, and co-expression of HBO1 and Jade1 increases histone acetylation and MCM complex loading. Overexpression of the Set8 histone H4 tail-binding domain speci...

  2. Transcriptional activation of the Epstein-Barr virus latency C promoter after 5-azacytidine treatment: evidence that demethylation at a single CpG site is crucial.

    Robertson, K D; Hayward, S D; Ling, P D; Samid, D; Ambinder, R F

    1995-01-01

    The Epstein-Barr Virus (EBV) latency C promoter (Cp) is the origin of transcripts for six viral proteins. The promoter is active in lymphoblastoid B-cell lines but silent in many EBV-associated tumors and tumor cell lines. In these latter cell lines, the viral episome is hypermethylated in the vicinity of this promoter. We show that in such a cell line (Rael, a Burkitt's lymphoma line), 5-azacytidine inhibits DNA methyltransferase, brings about demethylation of EBV genomes, activates Cp transcription, and induces the expression of EBNA-2. Investigation of the phenomenon demonstrates the importance of the methylation status of a particular CpG site for the regulation of the Cp: (i) genomic sequencing shows that this site is methylated when the Cp is inactive and is not methylated when the promoter is active; (ii) methylation or transition mutation at this site abolishes complex formation with a cellular binding activity (CBF2) as determined by electrophoretic mobility shift analyses, competition binding analyses, and DNase I footprinting; and (iii) a single C --> T transition mutation at this site is associated with a marked reduction (> 50-fold) of transcriptional activity in a reporter plasmid. Thus, the CBF2 binding activity is shown to be methylation sensitive and crucial to EBNA-2-mediated activation of the Cp. PMID:7565767

  3. Cause Analysis and Disposal Advice on Crack in Huzhun Second-tier Bridge Pier Tray and Top Hat%呼准二线桥墩托盘顶帽裂缝成因分析及处置意见

    徐华鑫

    2014-01-01

    With No.1 bridge pier in the inner Mongolia Coal railway as background , based on top hat crack dis-tribution in bridge pier tray , digital resiliometer was used for detecting concrete strength in crack densely-strewn area, supersonic detector was used for detecting width and depth of crack , and finally ANSYS is applied for pre-stress analysis .Through analysis on crack distribution and results from ANSYS , some advices are put forward to strengthen the No .1 bridge pier .%以内蒙古地方铁路呼准运煤专用线1号桥墩为背景,根据桥墩顶帽托盘的裂缝分布情况,采用数显回弹仪测试裂缝分布严重区域的混凝土强度,用超声波检测仪对裂缝的宽度和深度做了检测,通过有限元软件ANSYS对出现裂缝的区域做了应力分析。根据现场观察到的裂缝分布情况和有限元分析的结果,提出了对1号墩的加固和处置意见。

  4. Profiling of phenolic compounds and antioxidant activity of dry extracts from the selected Sorbus species.

    Olszewska, Monika A; Presler, Anna; Michel, Piotr

    2012-01-01

    The antioxidant efficiency of dry extracts from inflorescences and/or leaves of seven Sorbus species was studied using four in vitro tests of SET (single electron transfer) and HAT-type (hydrogen atom transfer) mechanisms. The 70% methanol extracts and its diethyl ether, ethyl acetate, n-butanol and water fractions were tested in parallel with the phenolic standards, e.g., caffeic acid, quercetin, BHA, BHT, and Trolox. The SET-type activity of the extracts depended primarily on the extraction solvent. The most valuable extracts were n-butanol and ethyl acetate ones, which activity was high in the DPPH (EC(50) = 3.2-5.2 μg/mL), TEAC (2.8-4.0 mmol Trolox/g), and FRAP (9.8-13.7 mmol Fe2+/g) tests, and strongly correlated with the total phenolic levels (39.6-58.2% of gallic acid equivalents). The HPLC-PDA analysis of the extracts led to the identification of chlorogenic acid, isoquercitrin, hyperoside, rutin, quercetin 3-O-sophoroside, and sexangularetin 3-O-β-D-glucopyranoside as the main components. Apart from flavonoids and hydroxycinnamic acids, proanthocyanidins have also a significant impact on the SET-type activity. The HAT-reactivity of the extracts in the linoleic acid peroxidation test (IC(50) = 36.9-228.3 μg/mL) depended more strongly on the plant tissue than on the extraction solvent, and its correlation with the phenolic content was weak. Both SET and HAT-type activity of the most potent Sorbus extracts was comparable with the activity of the standards, indicating their great potential as effective sources for health products. PMID:22410419

  5. Profiling of Phenolic Compounds and Antioxidant Activity of Dry Extracts from the Selected Sorbus Species

    Piotr Michel

    2012-03-01

    Full Text Available The antioxidant efficiency of dry extracts from inflorescences and/or leaves of seven Sorbus species was studied using four in vitro tests of SET (single electron transfer and HAT-type (hydrogen atom transfer mechanisms. The 70% methanol extracts and its diethyl ether, ethyl acetate, n-butanol and water fractions were tested in parallel with the phenolic standards, e.g., caffeic acid, quercetin, BHA, BHT, and TroloxÒ. The SET-type activity of the extracts depended primarily on the extraction solvent. The most valuable extracts were n-butanol and ethyl acetate ones, which activity was high in the DPPH (EC50 = 3.2–5.2 μg/mL, TEAC (2.8–4.0 mmol Trolox®/g, and FRAP (9.8–13.7 mmol Fe2+/g tests, and strongly correlated with the total phenolic levels (39.6–58.2% of gallic acid equivalents. The HPLC-PDA analysis of the extracts led to the identification of chlorogenic acid, isoquercitrin, hyperoside, rutin, quercetin 3-O-sophoroside, and sexangularetin 3-O-b-D-glucopyranoside as the main components. Apart from flavonoids and hydroxycinnamic acids, proanthocyanidins have also a significant impact on the SET-type activity. The HAT-reactivity of the extracts in the linoleic acid peroxidation test (IC50 = 36.9–228.3 μg/mL depended more strongly on the plant tissue than on the extraction solvent, and its correlation with the phenolic content was weak. Both SET and HAT-type activity of the most potent Sorbus extracts was comparable with the activity of the standards, indicating their great potential as effective sources for health products.

  6. Acetylation of retinal histones in diabetes increases inflammatory proteins: effects of minocycline and manipulation of histone acetyltransferase (HAT) and histone deacetylase (HDAC).

    Kadiyala, Chandra Sekhar Rao; Zheng, Ling; Du, Yunpeng; Yohannes, Elizabeth; Kao, Hung-Ying; Miyagi, Masaru; Kern, Timothy S

    2012-07-27

    Histone acetylation was significantly increased in retinas from diabetic rats, and this acetylation was inhibited in diabetics treated with minocycline, a drug known to inhibit early diabetic retinopathy in animals. Histone acetylation and expression of inflammatory proteins that have been implicated in the pathogenesis of diabetic retinopathy were increased likewise in cultured retinal Müller glia grown in a diabetes-like concentration of glucose. Both the acetylation and induction of the inflammatory proteins in elevated glucose levels were significantly inhibited by inhibitors of histone acetyltransferase (garcinol and antisense against the histone acetylase, p300) or activators of histone deacetylase (theophylline and resveratrol) and were increased by the histone deacetylase inhibitor, suberolylanilide hydroxamic acid. We conclude that hyperglycemia causes acetylation of retinal histones (and probably other proteins) and that the acetylation contributes to the hyperglycemia-induced up-regulation of proinflammatory proteins and thereby to the development of diabetic retinopathy. PMID:22648458

  7. Sex difference and menstrual cycle effects on semantic priming and rememberingAnlamsal hazırlama ve hatırlamada cinsiyet farkı ve menstural dönem etkileri

    Evrim Gülbetekin

    2015-02-01

    fluctuate across the menstrual cycle. The findings were discussed in the context of the negative effects of increasing luteinizing hormone (LH levels on attentional and executive functions in both ovulatory phase and Alzheimer’s disease. ÖzetAmaç: Kadınların ve erkeklerin bazı bilişsel işlemlerde ve hemisferik özelleşmelerde farklılık gösterdiği; buna karşın, cinsiyet farklılıklarına ilişkin çalışmaların her zaman çok tutarlı olmadığı bilinmektedir. Son dönemlerde yapılan çalışmalar, kadınlardaki bilişsel becerilerin menstural döneme bağlı olarak dalgalanma gösterebildiğine işaret etmiştir. Sunulan çalışmada erkeklerin ve farklı menstural dönemdeki kadınların (yumurtlama ve mensturasyon anlamsal hazırlama (AH ve hatırlama görevindeki peformansları yönünden farklılık gösterip göstermediğini incelemek amaçlanmıştır. Ayrıca AH görevinde cinsiyete özgü hemisferik özelleşme olup olmadığı incelenmiştir.Yöntem: Çalışmaya 72 kadın ve 29 erkek üniversite öğrencisi katılmıştır. AH görevi için katılımcılara arka arkaya iki resim gösterilmiştir. Görsel-yarı alan tekniği kullanılarak ve deney gruplarına uygun olarak ilk resim sol görsel alanda, sağ görsel alanda ya da merkezde100ms sunulmuş; katılımcılardan merkezde sunulan birinci resimle ikinci resmin ilişkili olup olmadığını belirtmeleri istenmiştir. AH görevinin ardından katılımcılara deneydeki uyarıcıların bir listesi verilmiş ve bunun içinden hatırladıklarını bir dakikalık sürede işartlemeleri istenmiştir.Bulgular: Tüm gruplarda AH etkisinin olduğu; ancak bu göreve ilişkin bir hemisferik özelleşmenin olmadığı bulunmuştur. Erkekler ilişkili resimleri yumurtlama dönemindeki kadınlardan daha hızlı değerlendirirken, mensturasyon dönemindeki kadınlarla böyle bir farklılık gözlenmemiştir. Benzer şekilde erkeklerin hatırladıkları genel uyarıcı ve ilişkisiz uyarıcı say

  8. Three-Corner Hat for the assessment of the uncertainty of non-linear residuals of space-geodetic time series in the context of terrestrial reference frame analysis

    Abbondanza, C.; Altamimi, Z.; Chin, T. M.; Gross, R. S.; Heflin, M. B.; Parker, J. W.; Wu, X.

    2015-04-01

    We discuss the application of the Three-Corner Hat (TCH) to time series of space-geodetic station position residuals with the purpose of characterizing the uncertainties of GPS, VLBI, SLR, DORIS for the International Terrestrial Reference Frame (ITRF) determination. Adopting simulations, we show that, in the absence of time-correlated errors, TCH is able to fully recover the nominal uncertainties of groups of observations whose intrinsic precisions are remarkably dissimilar to one another, as is the case for the space-geodetic techniques. When time-correlated errors are predominant, as it happens with GPS, TCH is affected by the increased variance of the observations and its estimates are positively biased. TCH applied to 16 ITRF co-located sites confirms that GPS, albeit affected by time-correlated errors, is the most precise of the space-geodetic techniques. GPS median uncertainties are 1.1, 1.2 and 2.8 mm, for the north, east and height component, respectively. VLBI performs particularly well in the horizontal component, the median uncertainties being mm. The height component is times larger than the GPS one. SLR and DORIS median uncertainties exceed by far the 7 mm level on all of the three components. Comparing TCH results with station position repeatabilities, we find that the two metrics are in striking agreement for VLBI and DORIS, but not for SLR and GPS. The inconsistencies between TCH and station repeatabilities for co-located GPS and SLR point to the presence of either specific station-dependent biases or low-quality co-locations. Scaling factors derived adopting the ratio between TCH and median formal errors on the positions suggest the station position covariances have to be up-scaled for VLBI, SLR, DORIS and down-scaled for GPS.

  9. Profiling of Phenolic Compounds and Antioxidant Activity of Dry Extracts from the Selected Sorbus Species

    Piotr Michel; Olszewska, Monika A.; Anna Presler

    2012-01-01

    The antioxidant efficiency of dry extracts from inflorescences and/or leaves of seven Sorbus species was studied using four in vitro tests of SET (single electron transfer) and HAT-type (hydrogen atom transfer) mechanisms. The 70% methanol extracts and its diethyl ether, ethyl acetate, n-butanol and water fractions were tested in parallel with the phenolic standards, e.g., caffeic acid, quercetin, BHA, BHT, and TroloxÒ. The SET-type activity of the extracts depended primarily on the extractio...

  10. NLO Jet Physics with BlackHat

    Berger, C.F.; /MIT, LNS; Bern, Z.; /UCLA; Dixon, L.J.; /SLAC; Cordero, F.Febres; /Simon Bolivar U.; Forde, D.; /CERN /NIKHEF, Amsterdam; Gleisberg, T.; /SLAC; Ita, H.; /UCLA; Kosower, D.A.; /DAPNIA, Saclay; Maitre, D.; /Durham U.

    2010-02-15

    We present several results obtained using the BLACKHAT next-to-leading order QCD program library, in conjunction with SHERPA. In particular, we present distributions for vector boson plus 1,2,3-jet production at the Tevatron and at the asymptotic running energy of the Large Hadron Collider, including new Z + 3-jet distributions. The Z + 2-jet predictions for the second-jet P{sub T} distribution are compared to CDF data. We present the jet-emission probability at NLO in W + 2-jet events at the LHC, where the tagging jets are taken to be the ones furthest apart in pseudorapidity. We analyze further the large left-handed W{sup {+-}} polarization, identified in our previous study, for W bosons produced at high P{sub T} at the LHC.

  11. Getting started with Red Hat Enterprise virtualization

    Subramanian, Pradeep

    2014-01-01

    If you are a system administrator who is interested in implementing and managing open source virtualization infrastructures, this is the book for you. A basic knowledge of virtualization and basic Linux command line experience is needed.

  12. Shaft Grouting HATS2A Hong Kong

    Strøm, Henrik

    2011-01-01

    In this thesis I have been following 5 grouting rounds at Cyberport shaft and 4 grouting rounds at Sandy Bay shaft.There were some communication problems between the grouting team and the geologists, resulting in missing water inflow measurements.The rock quality was very poor (Q-value 0.1 – 1), with coarse ash tuff as the most common rock mass in Cyberport, and rhyolitic tuff as the most common rock mass in Sandy Bay. The Q-values were below 1, with Cyberport just a bit higher than Sandy Bay...

  13. ALICE doffs hat to two companies

    2007-01-01

    During the fifth annual ALICE Industrial Awards ceremony, the ALICE Collaboration honoured two companies for their outstanding contributions to the construction of the experiment.For the past five years, the ALICE collaboration has been presenting its industrial partners with awards for meeting demanding or unusual requirements, for excellence in design or execution, for delivery on-time and on-budget and for outstanding cooperation. This year, on 9 March, ALICE presented awards to two companies for their exceptional performance. From left to right: Kees Oskamp (ALICE SSD), Arie de Haas (ALICE SSD), Gert-Jan Nooren (ALICE SSD), Shon Shmuel (FIBERNET), Yehuda Mor-Yosef (FIBERNET), Hans Boggild (ALICE), Jurgen Schukraft (ALICE Spokesperson), Catherine Decosse (ALICE) and Jean-Robert Lutz (ALICE SSD). FIBERNET Ltd., based in Yokneam, Israel, was rewarded for the excellent and timely assembly of the Silicon Strip Detector boards (SSD) of the Inner Tracking System with cable connections. Special low-mass cables, ...

  14. Computer Security: White hats for CERN

    Stefan Lueders, Computer Security Team

    2016-01-01

    CERN is under attack. Permanently. Even right now. In particular, the CERN web environment, with its thousands of websites and millions of webpages, is a popular target for evil-doers as well as for security researchers.   Usually, their attacks are unsuccessful and fade away over time. Sometimes, however, they are successful and manage to break into a CERN website or web server… It is imperative that we learn about our weaknesses before others do – and fix them! Hackers with bad intentions are usually named “black hats” as they misuse their power to cause destruction or downtime via any weakness they can find. “Grey hats” are more moderate and might just have some fun with the weaknesses they find, for example by putting naked teddy bears or a personal message (such as “I hacked U”) on the compromised website. Last but not least, “white hats” report their findings directly to us and suggest that...

  15. Advanced nursing practice: old hat, new design.

    De Grasse, C; Nicklin, W

    2001-01-01

    Advanced practice nurses positively impact the delivery of healthcare and client outcomes. However, in the past these positions have been seen to have variable value and were often vulnerable during budget cuts. Lack of a clear advanced nursing practice (ANP) framework probably contributed to the compromised effectiveness of these roles and evolution of roles with different titles, scopes of practice and reporting structures. To build the foundation for developing an ANP framework, a task force at The Ottawa Hospital (TOH) conducted a literature review related to ANP roles and completed a review of all clinical nursing roles at TOH. In addition, focus groups with nurses and other health professionals elicited ANP perceptions. The ANP framework includes a standardized job description that details competencies under five role components: clinical practice; consultation; research; education; and, leadership. Recommendations for assessment, implementation and evaluation of ANP roles are identified. The process undertaken by our ANP task force proved to be thorough and sound in developing a framework within which to move forward with ANP role implementation throughout TOH. This article, describing the process, may assist other organizations in defining ANP roles to better meet patient needs in changing health care environments. PMID:11803945

  16. Hats off to CERN's Master of Apprenticeships!

    2004-01-01

    Roland Gay of the HR Department (at right) recently received a special diploma from the Geneva Industrial Union (UIG). Presented by Carlo Lamprecht, Head of the Department of Economy, Employment and External Affairs of the State of Geneva, the diploma was awarded in recognition of the 199 CERN apprentices Roland has guided through the Certificat Fédéral de Capacité (CFC), an end-of-apprenticeship certificate awarded by the Cantonal authorities. Roland will be retiring in December 2004 after 37 years of service, 32 of which he spent in the role of apprenticeship supervisor.

  17. The Food Service Director's Many Hats.

    Carr, Deborah Hutcherson

    2003-01-01

    Describes qualifications and responsibilities for the position of school nutrition director. Based on guide published by the National Food Service Management Institute called "Competencies, Knowledge and Skill Statements for District School Nutrition Directors/Supervisors." Guide is available at www.nfsmi.org. (PKP)

  18. Habitat Testbed (HaT) Project

    National Aeronautics and Space Administration — Goals of the DSH Testbed include:Function as a habitat systems integrator and technology pull across many domainsDevelop and integrate software-based models of...

  19. Switching Hats: From Accessibility to Possibility

    Sarah McGann

    2009-11-01

    Full Text Available Neil is a sporty, outdoorsy sort of bloke. He spends verylittle time at home, preferring to golf, surf, go to the footy and hang out with his mates: You can tell just by looking inside his house—a huge TV in the darkened lounge, and golf equipment, surf boards and motorbike gear fill up the room. That was before last October. Now, in June, Neil is a paraplegic, his house is inaccessible and his boys-toys are in the way. For Neil, his home, previously an inwardly focused place to sleep and store, will become the centre of his world (when he can eventually get into it. Initially, accessibility is the key problem to be solved. To this end the architectural advisor from the rehabilitation unit proposed formulaic adjustments to the bathroom to allow for wheelchair access. However, accessibility is only one facet of the problem. This environment, relatively unimportant before,now needs to enable and inspire the occupant both physically and emotionally. As physical abilities dramatically change the spatial practices of everyday life also change.The home environment is ever more important to support and help heal emotional scarring after a life-changing event.In the context of shorter hospital and rehabilitation stays,the home provides a vital extension to the healthcare system. Therefore it is important that architectural advice given to enable this move considers the holistic qualities ofdesign thinking rather than be restricted to short-term solutions.

  20. Hats off to the particle suppliers

    Rolf Heuer

    2010-01-01

    A couple of weeks into the LHC’s first high energy physics run, and we’ve already got an impressive story to tell. Long fills for physics are becoming routine, luminosity scans have increased the collision rate. The operators are becoming adept at squeezing the beams ever smaller, and higher intensity studies are progressing well. With the experiments, it’s the same story.   Following the plots that the spokespersons were able to show on 30 March after just one hour of running, the experiments have already made significant inroads into re-measuring all the Standard Model parameters necessary to ensure that they fully understand their detectors before any new discoveries can be announced. It’s impressive stuff, and the attention is rightly on the LHC and its experiments. But we shouldn’t lose sight of the fact that all this relies on the seamless operation of many other systems. Starting from a deceptively simple bottle of hydrogen, an LHC proton ...

  1. Structure-thermodynamics-antioxidant activity relationships of selected natural phenolic acids and derivatives: an experimental and theoretical evaluation.

    Yuzhen Chen

    Full Text Available Phenolic acids and derivatives have potential biological functions, however, little is known about the structure-activity relationships and the underlying action mechanisms of these phenolic acids to date. Herein we investigate the structure-thermodynamics-antioxidant relationships of 20 natural phenolic acids and derivatives using DPPH• scavenging assay, density functional theory calculations at the B3LYP/6-311++G(d,p levels of theory, and quantitative structure-activity relationship (QSAR modeling. Three main working mechanisms (HAT, SETPT and SPLET are explored in four micro-environments (gas-phase, benzene, water and ethanol. Computed thermodynamics parameters (BDE, IP, PDE, PA and ETE are compared with the experimental radical scavenging activities against DPPH•. Available theoretical and experimental investigations have demonstrated that the extended delocalization and intra-molecular hydrogen bonds are the two main contributions to the stability of the radicals. The C = O or C = C in COOH, COOR, C = CCOOH and C = CCOOR groups, and orthodiphenolic functionalities are shown to favorably stabilize the specific radical species to enhance the radical scavenging activities, while the presence of the single OH in the ortho position of the COOH group disfavors the activities. HAT is the thermodynamically preferred mechanism in the gas phase and benzene, whereas SPLET in water and ethanol. Furthermore, our QSAR models robustly represent the structure-activity relationships of these explored compounds in polar media.

  2. The Effect To The Student Success Of Being Applied With The Hexagonal Hat Drama Technique Of The Subject Called “The Principles Of Revolutions Of Atatürk” In The Unit Of “How Did We Reach ‘Republic’?” In The Lesson Of Social Sciences In The 5th Grades Of

    Yener ÖZEN; Abdulkadir GÜL; GÜLAÇTI, Fikret

    2008-01-01

    In the primary Education level, learning generally doesn’t take place mean- ingfully because the instruction is traditionally based on direct instruction and sub- jects being taught are not thoroughly experienced for teaching The History of Atatürk’s Principles and Revolutions. Nevertheless, the purpose of learning is to provide the human being with the perpetual behavior change as a result of the inter- action with the environment.In this study, it is found that “The Hexagonal Hat Role Playi...

  3. Synthesis of benzamide derivatives of anacardic acid and their cytotoxic activity.

    Chandregowda, Venkateshappa; Kush, Anil; Reddy, Goukanapalli Chandrasekara

    2009-06-01

    Several benzamide derivatives were synthesized from anacardic acid (1a) which was the product of hydrogenation of the naturally occurring anacardic acid mixture (1a-d), a major constituent of cashew nut shell liquid. Anacardic acid (1a) was first alkylated followed by hydrolysis of the ester to obtain synthones namely, 2-ethoxy-6-pentadecylbenzoic acid (5) and 2-isopropoxy-6-pentadecylbenzoic acid (6). These salicylic acid derivatives were then coupled with a variety of anilines to obtain novel benzamide compounds (7-39). Cytotoxic effect of these synthesized compounds was tested on HeLa cell line of wild type with relatively high expression of p300 and on HCT-15, which is p300 negative. Of all the compounds, 2-isopropoxy-6-pentadecyl-N-pyridin-4-ylbenzamide (27), 2-ethoxy-N-(3-nitrophenyl)-6-pentadecylbenzamide (22) and 2-ethoxy-6-pentadecyl-N-pyridin-4-ylbenzamide (10) were found to be more potent with the respective IC(50) values 11.02 microM, 13.55 microM, 15.29 microM on HeLa cell line. Their activities are comparable with garcinol which is a cell permeable histone acetyltransferase (HAT) inhibitor and 10 fold more active than p300 HAT activators so far reported. PMID:19246131

  4. Epigenetic regulation of proliferation and invasion in hepatocellular carcinoma cells by CBP/p300 histone acetyltransferase activity.

    Inagaki, Yuji; Shiraki, Katsuya; Sugimoto, Kazushi; Yada, Takazumi; Tameda, Masahiko; Ogura, Suguru; Yamamoto, Norihiko; Takei, Yoshiyuki; Ito, Masaaki

    2016-02-01

    Altered epigenetic control of gene expression plays a substantial role in tumor development and progression. Accumulating studies suggest that somatic mutations of CREB binding proteins (CBP)/p300 occur in some cancer cells. CBP/p300 possess histone acetyltransferase (HAT) activity, and are involved in many cellular processes. In this study, we investigated the expression and functional role of CBP/p300 in hepatocellular carcinoma (HCC) using the specific inhibitor C646 of CBP/p300 HAT activity. We examined its effect on several apoptosis-related proteins and invasion-related genes. The results showed that CBP/p300 were highly expressed in HCC tissues and that expression of p300, but not of CBP, was strongly correlated with the malignant character of HCC. C646 inhibited proliferation of HCC cell lines in a dose dependent manner. C646 significantly augmented TRAIL-induced apoptotic sensitivity, which was accompanied by reduced levels of survivin, in HepG2, HLE and SK-HEP1 cells. C646 significantly inhibited invasion of Huh7, HLE and SK-HEP1 cells. The level of matrix metallopeptidase 15 (MMP15) mRNA expression was significantly reduced, whereas the level of laminin alpha 3 (LAMA3) and secreted phosphoprotein 1 (SPP1) mRNA expression was significantly increased in Huh7 cells following exposure to C646. In conclusion, our results suggest that CBP/p300 HAT activity has an important role in malignant transformation, proliferation, apoptotic sensitivity and invasion in HCC. CBP/p300 could be a promising therapeutic target in HCC. PMID:26676548

  5. Sonodelivery Facilitates Sustained Luciferase Expression from an Episomal Vector in Skeletal Muscle

    Manoel Figueiredo Neto

    2015-07-01

    Full Text Available Successful gene delivery to skeletal muscle is a desirable goal, not only for treating muscle diseases, but also for immunization, treatment of metabolic disorders, and/or delivering gene expression that can treat systemic conditions, such as bone metastatic cancer, for example. Although naked DNA uptake into skeletal muscle is possible, it is largely inefficient in the absence of additional chemical or physical delivery methods. We describe a system for delivery of non-viral or plasmid DNA to skeletal muscle using ultrasound-assisted sonoporation of a nanoplex combining plasmid DNA and a branched polymer based on poly(cyclooctene-graft-oligopeptide. The materials and methods described herein promise to advance the field of sonodelivery and of gene delivery to muscle for therapeutic applications since a simple system is presented that enables long-term gene expression in vivo with the promise of a minimal inflammatory gene expression profile.

  6. A high-throughput protein expression system in Pichia pastoris using a newly developed episomal vector

    We describe here the construction of a Gateway-compatible vector, pBGP1-DEST, for rapid and convenient preparation of expression plasmids for production of secretory proteins in Pichia pastoris. pBGP1-DEST directs the synthesis of a fusion protein consisting of the N-terminal signal and pro-sequence...

  7. Cihan Harbinin Karanlığında Aydınlığı Hatırla(tmak: Ömer Seyfettin’in Kaleminden Kahramanlara Dair

    Melih Erzen

    2014-06-01

    Full Text Available I. Dünya Savaşı, Avrupa ülkelerinin ekonomik çıkarları ve anlaşmazlıklarından beslenen bir savaş olup büyük yıkımları da beraberinde getirmiştir. Söz konusu tarihlerde zaten yeterince müşkül durumda bulunan Osmanlı Devleti, müdahil olduğu bu savaş dolayısıyla daha da büyük kayıplar vermiştir. Elbette ki bir savaşta alınan zafer yahut yenilgiler, savaşan ülkenin yalnızca askeri birliklerini değil bütün bir halkını ilgilendirmekte ve etkilemektedir. Toplumun birer ferdi olarak hemen her sanatçı bu tür büyük olaylardan etkilendiği gibi ayrıca toplumun sözcülüğünü üstlenmek adına yola çıkan sanatçılar da bulunmaktadır. Sosyolojik yönü bulunan edebiyat için de durumun böyle olduğunu görürüz. Edebi eserler üzerine yapılan incelemeler, bu metinlerin zaman zaman toplum meselelerini takip etmek veya toplumun ahvalini anlayabilmek açısından imkân tanıdığını kanıtlamıştır. Nitekim Türk toplumunu derinden etkileyen I. Dünya Savaşı’nın yansımalarına da edebi eserler üzerinden ulaşmanın mümkün olduğu söylenebilir. Ömer Seyfettin’in birçoğunu 1917-1918 yılları arasında Yeni Mecmua’da yayımladığı öyküleri bu duruma iyi bir örnek teşkil eder. “Eski Kahramanlar” başlığı altındaki hikâyelerinde eski zaman dilimlerini esas alarak kahraman tipleri resmeden Ömer Seyfettin, milletinin taşıdığı cevherleri hatırlatmak suretiyle topluma ve askerlere moral vermeyi amaçlar. Onun yine aynı tarihlerde “Yeni Kahramanlar” üst başlığı ile yazdığı birkaç hikâye ise Çanakkale Savaşı’nın olumlu havasını ve başarısını yansıtmaya yöneliktir. Bu çalışmanın amacı, Ömer Seyfettin’in “Eski Kahramanlar” ve “Yeni Kahramanlar” üst başlıkları altında yayımlanan hikâyelerinden yola çıkarak “kahraman” tanımlaması içerisine oturtulan hikâye kişilerini ve bu kişilerin vasıflarını incelemektir.

  8. Activation of GATA4 gene expression at the early stage of cardiac specification

    Yilbas, Ayse; Hamilton, Alison; Wang, Yingjian; Mach, Hymn; Lacroix, Natascha; Davis, Darryl; Chen, Jihong; LI, Qiao

    2014-03-01

    Currently, there are no effective treatments to directly repair damaged heart tissue after cardiac injury since existing therapies focus on rescuing or preserving reversibly damaged tissue. Cell-based therapies using cardiomyocytes generated from stem cells present a promising therapeutic approach to directly replace damaged myocardium with new healthy tissue. However, the molecular mechanisms underlying the commitment of stem cells into cardiomyocytes are not fully understood and will be critical to guide this new technology into the clinic. Since GATA4 is a critical regulator of cardiac differentiation, we examined the molecular basis underlying the early activation of GATA4 gene expression during cardiac differentiation of pluripotent stem cells. Our studies demonstrate the direct involvement of histone acetylation and transcriptional coactivator p300 in the regulation of GATA4 gene expression. More importantly, we show that histone acetyltransferase (HAT) activity is important for GATA4 gene expression with the use of curcumin, a HAT inhibitor. In addition, the widely used histone deacetylase inhibitor valproic acid enhances both histone acetylation and cardiac specification.

  9. SU-E-J-144: Low Activity Studies of Carbon 11 Activation Via GATE Monte Carlo

    Purpose: To investigate the behavior of a Monte Carlo simulation code with low levels of activity (∼1,000Bq). Such activity levels are expected from phantoms and patients activated via a proton therapy beam. Methods: Three different ranges for a therapeutic proton radiation beam were examined in a Monte Carlo simulation code: 13.5, 17.0 and 21.0cm. For each range, the decay of an equivalent length11C source and additional sources of length plus or minus one cm was studied in a benchmark PET simulation for activities of 1000, 2000 and 3000Bq. The ranges were chosen to coincide with a previous activation study, and the activities were chosen to coincide with the approximate level of isotope creation expected in a phantom or patient irradiated by a therapeutic proton beam. The GATE 7.0 simulation was completed on a cluster node, running Scientific Linux Carbon 6 (Red Hat©). The resulting Monte Carlo data were investigated with the ROOT (CERN) analysis tool. The half-life of11C was extracted via a histogram fit to the number of simulated PET events vs. time. Results: The average slope of the deviation of the extracted carbon half life from the expected/nominal value vs. activity showed a generally positive value. This was unexpected, as the deviation should, in principal, decrease with increased activity and lower statistical uncertainty. Conclusion: For activity levels on the order of 1,000Bq, the behavior of a benchmark PET test was somewhat unexpected. It is important to be aware of the limitations of low activity PET images, and low activity Monte Carlo simulations. This work was funded in part by the Philips corporation

  10. Die Deutsche Zentralbibliothek für Medizin hat ihr Suchportal für Medizin und Gesundheitswesen um einen entscheidenden Schritt weiterentwickelt: Integration der Bibliothekskontofunktion in MEDPILOT [The German National Library of Medicine has extended the functions of the search portal for Medicine and Health by adding an important feature: the integration of the user accounts in MEDPILOT

    Hinnenthal, Kendra

    2012-09-01

    Full Text Available [english] In order to provide users fast access to the order- and account functions of the “Medicine. Health.” catalogue, the German National Library of Medicine has completely integrated these functions into the search portal MEDPILOT. This article presents the objectives, the implementation and its evaluation through a usability study.[german] Um den Nutzern über nur einen Rechercheeinstieg in MEDPILOT auch Bestell- und Kontofunktionen des Kataloges Medizin. Gesundheit. bieten zu können, hat die Deutsche Zentralbibliothek für Medizin (ZB MED diese Funktionen des OPAC komplett in MEDPILOT eingebunden. Der Artikel stellt die Zielsetzung, die organisatorische Umsetzung sowie die Evaluation durch eine Usability-Studie vor.

  11. A novel high-throughput activity assay for the Trypanosoma brucei editosome enzyme REL1 and other RNA ligases

    Zimmermann, Stephan; Hall, Laurence; Riley, Sean; Sørensen, Jesper; Amaro, Rommie E.; Schnaufer, Achim

    2016-01-01

    The protist parasite Trypanosoma brucei causes Human African trypanosomiasis (HAT), which threatens millions of people in sub-Saharan Africa. Without treatment the infection is almost always lethal. Current drugs for HAT are difficult to administer and have severe side effects. Together with increasing drug resistance this results in urgent need for new treatments. T. brucei and other trypanosomatid pathogens require a distinct form of post-transcriptional mRNA modification for mitochondrial gene expression. A multi-protein complex called the editosome cleaves mitochondrial mRNA, inserts or deletes uridine nucleotides at specific positions and re-ligates the mRNA. RNA editing ligase 1 (REL1) is essential for the re-ligation step and has no close homolog in the mammalian host, making it a promising target for drug discovery. However, traditional assays for RELs use radioactive substrates coupled with gel analysis and are not suitable for high-throughput screening of compound libraries. Here we describe a fluorescence-based REL activity assay. This assay is compatible with a 384-well microplate format and sensitive, satisfies statistical criteria for high-throughput methods and is readily adaptable for other polynucleotide ligases. We validated the assay by determining kinetic properties of REL1 and by identifying REL1 inhibitors in a library of small, pharmacologically active compounds. PMID:26400159

  12. Semisynthesis and quantitative structure-activity relationship (QSAR) study of some cholesterol-based hydrazone derivatives as insecticidal agents.

    Yang, Chun; Shao, Yonghua; Zhi, Xiaoyan; Huan, Qu; Yu, Xiang; Yao, Xiaojun; Xu, Hui

    2013-09-01

    In continuation of our program aimed at the discovery and development of natural-product-based insecticidal agents, four series of novel cholesterol-based hydrazone derivatives were synthesized, and their insecticidal activity was tested against the pre-third-instar larvae of oriental armyworm, Mythimna separata (Walker) in vivo at 1mg/mL. All the derivatives showed the better insecticidal activity than their precursor cholesterol. Quantitative structure-activity relationship (QSAR) model demonstrated that six descriptors such as RDF085v, Mor06u, Mor11u, Dv, HATS0v and H-046, are likely to influence the insecticidal activity of these compounds. Among them, two important ones are the Mor06u and RDF085v. PMID:23891182

  13. Interaction of Papillomavirus E2 Protein with the Brm Chromatin Remodeling Complex Leads to Enhanced Transcriptional Activation▿

    Ajay Kumar, R.; Naidu, Samisubbu R.; Wang, Xiaoyu; Imbalzano, Anthony N.; Androphy, Elliot J.

    2006-01-01

    Papillomavirus E2 is a sequence-specific DNA binding protein that regulates transcription and replication of the viral genome. The transcriptional activities of E2 are typically evaluated by transient transfection of nonreplicating E2-dependent reporters. We sought to address whether E2 activates transcription in an episomal context and its potential interaction with the chromatin remodeling proteins. Using an Epstein-Barr virus-based episomal reporter, we demonstrate that E2 stimulates trans...

  14. Cognitive Approach Based User Node Activity Monitoring for Intrusion Detection in Wireless Networks

    G Sunilkumar

    2012-03-01

    Full Text Available Cognitive networks are the solution for the problems existing on the current networks. Users maintain integrity of the networks and user node activity monitoring is required for provision of security. Cognitive Networks discussed in this paper not only monitor user node activity but also take preventive measures if user node transactions are malicious. The intelligence in cognitive engine is realized using self-organizing maps (CSOMs. Gaussian and Mexican Hat neighbor learning functions have been evaluated to realize CSOMs. Experimental study proves the efficiency of Gaussian Learning function is better for cognition engine. The cognition engine realized is evaluated for malicious node detection in dynamic networks. The proposed concept results in better Intrusion detection rate as compared to existing approaches.

  15. Theoretical investigation on antioxidant activity of vitamins and phenolic acids for designing a novel antioxidant

    Mohajeri, Afshan; Asemani, S. Somayeh

    2009-07-01

    Theoretical calculations have been performed to predict antioxidant property for two interesting classes of compounds including phenolic acids and vitamins. Important characteristics of antioxidants such as O-H bond dissociation enthalpy (BDE) and ionization potential (IP) were calculated in the gas-phase to analyze the effect of heterocyclic ring, intramolecular hydrogen bonding and presence of electron donating group near the O-H on the antioxidant activity. The results reveal that the presence of intramolecular hydrogen bonding through ortho-hydroxy group lowers BDE, IP and spin density. In general, phenolic acids were found to be more effective antioxidant than vitamins. The H-atom transfer (HAT) mechanism was selected to study the hydrogen abstraction from phenolic compounds by hydroperoxyl radical. It is found that the antioxidant with lower BDE undergoes hydrogen abstraction with low barrier and considerable exothermicity. On the basis of these results we were able to design a novel antioxidant with enhanced activity.

  16. Görsellerle Desteklenmiş Altı Şapka Düşünme Tekniğinin Öğrencilerin Konuşma Becerilerini Geliştirmesine Etkisi Six Thinking Hats Technique Supported Visuals Effects of Students' Speaking Skills Develop

    Salih ORHAN

    2012-09-01

    Full Text Available to express oneself to communicate as a society to provide others. Inthis sense, individuals benefit from the ability to talk in daily life themost. Speaking a language skill can be developed which are used in avariety of methods to be used more effectively.The main objective of this study, elementary school studentsimprove their speaking skills supported by visuals than the traditionalmethod to determine the effect of six hat thinking techniques. Theprimary purpose of research 8th grade students for a period of fourweeks 'of Science and Technology' theme applied The data "SpeakingObservation Form" (Orhan, 2010 collected the data. Visuals supportedby the experimental group, while speaking activities, speaking in thecontrol group were carried out according to conventional method. Inthis context, information about the method, first given to students inthe experimental group, how to implement this method, the researcherexplained to the students by students. Then, for each color of the sixhat thinking techniques were made in the speech handed out picturesto students. The data were evaluated with SPSS 19.0, to compare withthose of the pre-test and post-test "for the measurements associatedwith the Wilcoxon signed Ranks Test" was used. As a result 'speechrules, Effective use of voice and body language, be prepared to makespeeches, their speech evaluation' goals and achievements, such as thedevelopment of speech in the Turkish Course Programme of theexperimental group students was found to be more successful than thecontrol group students and and a variety of applications related toproposing and speaking skills teachers can use this method unlessotherwise indicated. Eğitimin en temel hedeflerinden biri de insanın kendisini ifade edebilmesini ve toplumsal bir varlık olarak toplumun diğer bireyleriyle iletişim kurabilmesini sağlamaktır. Bu anlamda bireyler günlük hayatta en çok konuşma becerisinden faydalanmaktadırlar. Geliştirilebilir bir

  17. Substrate-dependent activation of the Vibrio cholerae vexAB RND efflux system requires vexR.

    Dawn L Taylor

    Full Text Available Vibrio cholerae encodes six resistance-nodulation-division (RND efflux systems which function in antimicrobial resistance, virulence factor production, and intestinal colonization. Among the six RND efflux systems, VexAB exhibited broad substrate specificity and played a predominant role in intrinsic antimicrobial resistance. The VexAB system was encoded in an apparent three gene operon that included vexR; which encodes an uncharacterized TetR family regulator. In this work we examined the role of vexR in vexRAB expression. We found that VexR bound to the vexRAB promoter and vexR deletion resulted in decreased vexRAB expression and increased susceptibility to VexAB antimicrobial substrates. Substrate-dependent induction of vexRAB was dependent on vexR and episomal vexR expression provided a growth advantage in the presence of the VexAB substrate deoxycholate. The expression of vexRAB increased, in a vexR-dependent manner, in response to the loss of RND efflux activity. This suggested that VexAB may function to export intracellular metabolites. Support for this hypothesis was provided by data showing that vexRAB was upregulated in several metabolic mutants including tryptophan biosynthetic mutants that were predicted to accumulate indole. In addition, vexRAB was found to be upregulated in response to exogenous indole and to contribute to indole resistance. The collective results indicate that vexR is required for vexRAB expression in response to VexAB substrates and that the VexAB RND efflux system modulates the intracellular levels of metabolites that could otherwise accumulate to toxic levels.

  18. Substrate-dependent activation of the Vibrio cholerae vexAB RND efflux system requires vexR.

    Taylor, Dawn L; Ante, Vanessa M; Bina, X Renee; Howard, Mondraya F; Bina, James E

    2015-01-01

    Vibrio cholerae encodes six resistance-nodulation-division (RND) efflux systems which function in antimicrobial resistance, virulence factor production, and intestinal colonization. Among the six RND efflux systems, VexAB exhibited broad substrate specificity and played a predominant role in intrinsic antimicrobial resistance. The VexAB system was encoded in an apparent three gene operon that included vexR; which encodes an uncharacterized TetR family regulator. In this work we examined the role of vexR in vexRAB expression. We found that VexR bound to the vexRAB promoter and vexR deletion resulted in decreased vexRAB expression and increased susceptibility to VexAB antimicrobial substrates. Substrate-dependent induction of vexRAB was dependent on vexR and episomal vexR expression provided a growth advantage in the presence of the VexAB substrate deoxycholate. The expression of vexRAB increased, in a vexR-dependent manner, in response to the loss of RND efflux activity. This suggested that VexAB may function to export intracellular metabolites. Support for this hypothesis was provided by data showing that vexRAB was upregulated in several metabolic mutants including tryptophan biosynthetic mutants that were predicted to accumulate indole. In addition, vexRAB was found to be upregulated in response to exogenous indole and to contribute to indole resistance. The collective results indicate that vexR is required for vexRAB expression in response to VexAB substrates and that the VexAB RND efflux system modulates the intracellular levels of metabolites that could otherwise accumulate to toxic levels. PMID:25695834

  19. Multistability of memristive Cohen-Grossberg neural networks with non-monotonic piecewise linear activation functions and time-varying delays.

    Nie, Xiaobing; Zheng, Wei Xing; Cao, Jinde

    2015-11-01

    The problem of coexistence and dynamical behaviors of multiple equilibrium points is addressed for a class of memristive Cohen-Grossberg neural networks with non-monotonic piecewise linear activation functions and time-varying delays. By virtue of the fixed point theorem, nonsmooth analysis theory and other analytical tools, some sufficient conditions are established to guarantee that such n-dimensional memristive Cohen-Grossberg neural networks can have 5(n) equilibrium points, among which 3(n) equilibrium points are locally exponentially stable. It is shown that greater storage capacity can be achieved by neural networks with the non-monotonic activation functions introduced herein than the ones with Mexican-hat-type activation function. In addition, unlike most existing multistability results of neural networks with monotonic activation functions, those obtained 3(n) locally stable equilibrium points are located both in saturated regions and unsaturated regions. The theoretical findings are verified by an illustrative example with computer simulations. PMID:26277610

  20. 8. sınıf T. C. İnkılap Tarihi ve Atatürkçülük dersinde harita üzerinde oynanan kutu oyunları kullanımının öğrenci başarısı ve hatırda tutmaya etkisi

    Bayram, Bilal

    2015-01-01

    Bu çalışmada, 8. sınıf T.C. İnkılap Tarihi ve Atatürkçülük dersi öğretiminde, kutu oyunları kullanımının öğrenci ders başarısına ve hatırda tutma düzeyine etkisi üzerinde durulmuştur. Ayrıca öğrencilerin kendi öğrenmelerinden sorumlu olduğu bir öğrenme ortamı oluşturulmasında kuralları önceden belirlenmiş ve kazanımlar doğrultusunda hazırlanmış kutu oyunlarının etkili ve eğlenceli bir materyal olabileceğine dikkat çekilmiştir. Çalışmayla, öğrencilerin oyun esnasındaki yüksek güdülenmişlik sev...

  1. "Erlösung ist, wenn man schulfrei hat!". Erste Ergebnisse einer qualitativ-empirischen Studie zur Erfassung und didaktischen Bearbeitung von Erlösungsvorstellungen 10- bis 14-jähriger SchülerInnen der Sekundarstufe I in Österreich.

    Thomas Weiß

    2014-07-01

    Full Text Available ENGLISH: The teaching of redemption of mankind through God in Jesus Christ is fundamental to the Christian religion. This article expands on this central topic and presents the first results of a research carried out in schools as part of a current qualitative study about what ideas of redemption ten- to fourteen-year-old students have. The aim of this basic empirical research is to generate views and perspectives on ‚redemption‘ in children and adolescents. A further objective is to develop and integrate didactic tasks for Religious Education as a subject, in order to work on the topic of ‚redemption‘. By doing so, theological reflection should be applied and an alignment within the spheres of life of young people should be provided in lessons at School. DEUTSCH: Die Rede von der Erlösung des Menschen durch Gott in Jesus Christus ist für die christliche Religion fundamental. Der Beitrag widmet sich diesem zentralen Thema und präsentiert die ersten Forschungsergebnisse, die im Rahmen einer aktuellen qualitativen Studie zu Erlösungsvorstellungen von 10- bis 14-jährigen SchülerInnen in Schulen erhoben wurde. Diese grundlagenorientierte empirische Forschungsarbeit hat zum Ziel, kindliche / jugendliche Denk- und Sichtweisen zu ‚Erlösung’ zu generieren und didaktische Aufgaben im Religionsunterricht zu entwickeln und zu implementieren, um das Thema ‚Erlösung’ lebensweltlich orientiert und theologisch reflektiert im schulischen Unterricht bearbeiten zu können.

  2. MM5模式在高性能系统FreeBSD上的移植及其与RHAS 4的性能比较%Transplantation of MM5 on FreeBSD and Comparison with Red Hat Advanced Server 4 on Linux

    刘澈; 俞斌翔; 闫淑莲

    2007-01-01

    MM5模式系统常被用在气象科研和天气预报当中,通常运行在商业版本的Unix/Linux系统上,对非商业版本的类Unix系统并不太友好.文章详细介绍了MM5V3.7在高性能免费Unix操作系统FreeBSD 6.0上的移植及其应注意的问题,并通过一个个例分别在FreeBSD 6.0和Red Hat Advanced Server 4(RHAS 4)上的运行来比较其效率.通过对比发现,FreeBSD的性能要比通常所用的Linux系统有较大的提高,这对于改善实际业务中的时间迫切性问题有很大的意义.

  3. A tőkeerő és az alapítói háttér hatása a kockázatitőke-szervezetek befektetési magatartására II.

    Ludányi, Arnold

    2001-01-01

    A kétrészes tanulmány a kockázatitőke-ágazat befektetőszervezeteinek egyes csoportjait hasonlítja össze. Empirikus módszerrel vizsgálja az alapítói háttér és a tőkeerő feltételezett hatásait a magyar kockázatitőke-szervezetek magatartási jellemzőinek alakulására. Az alább következő második rész a kockázatitőke-szervezetekről szóló kutatás eredményeit az első részben ismertetett elemzési keret szerint foglalja össze, górcső alá véve a döntési folyamat jellemzőit, a befektetési portfólió kezelé...

  4. Long-term denudation rates from the Central Andes (Chile estimated from a Digital Elevation Model using the Black Top Hat function and Inverse Distance Weighting: implications for the Neogene climate of the Atacama Desert Tasas de denudación de largo tiempo en los Andes Centrales, Chile, estimadas a partir de un modelo digital de elevación usando la función 'Top Hat' por cierre y la interpolación ponderada por el inverso de la distancia: implicancias del clima Neógeno del Desierto de Atacama

    Rodrigo Riquelme

    2008-01-01

    Full Text Available A methodology for determining long-term denudation rates from morphologic markers in a Digital Elevation Model (DEM is checked by a comparative study of two drainage basins in the PrecordiUera of the Central Andes. In both cases the initial configuration of an incised pediment surface has been restored by using two different methods: the Black Top Hat (BTH function and the Inverse Distance Weighting (IDW interpolation. Where vertical incision and hillslope erosion are recorded, the IDW appears to be the most adequate to reconstitute the pediment surfaces. Conversely, where only vertical incision is observed, the BTH describes more precisely the former pediment surfaces and it is easier to solve. By subtracting the DEM from the reconstructed marker we calculated an eroded volume, and estimated its uncertainty by considering Root Mean Square Error (RMSE and DEM grid error. For the last ~10 Myr we obtained long-term denudation rates of 7.33±1.6 m/Myr in the San Andrés drainage basin and 13.59±1.9 m/Myr in the El Salado drainage basin. These estimations are largely in agreement with other reported estimates of long-term denudation rates in the Atacama Desert. Comparison with long-term denudation rates reported in a wide range of climatic regimes suggests that our estimates cannot be explained by the current rainfall in the PrecordiUera. However they could be explained by a rainfall similar to that reported 40 km to the east in the Puna. This suggests that during the time span concerned the geomorphologic evolution of the study area, this evolution is dominated by an orographically controlled rainfall pattern. The preserved pediment surface and the small long term denudation rates determined in this study also indicate that the PrecordiUera was never reached by humid tropical air masses and precipitation as currently observed in the Altiplano during the summer monthsUna metodología para determinar tasas de denudación de largo tiempo a partir de

  5. A szélsőséges időjárási jelenségek hatásai (Effects of the Extreme Weather Events

    Tamás Molnár

    2015-04-01

    Full Text Available Economist Sir Nicholas Stern warned that the global warming could cause major blow to the world economy than the two world wars and the crisis in the 1930s. But where are we in this process now and what can be expected in the near future and what opportunities we are to curb the negative effects and to slow down the global warming. The world’s population is more than 7 billion people now and we will live more than 9 billion on the planet in 2050 according to the conservative estimation because daily the number of inhabitants increases by approximitaly a quarter of a million people (National Rural Strategy, 2020. The water and ecosystem resources are diminishing due to overuse and the values of ecological footprint are very high especially in the developed countries. The increase of extreme weather events and its effects associated with the global warming have also growing impact on agricultural production. This phenomenon is important because to solve the famine and the water shortage will be much bigger problem due to climate change than today. The VAHAVA reports (change-impact-response draw also attention to the issue which is also important for experts of climate change: Is it clearly climate change and if so than what the role of the human activity in it is? It seems clear that the assumption is almost poetic as the earth sends clear messages: the concentration of greenhouse gases increased suddenly in the atmosphere (carbon-dioxide, methan, nitrous oxide, etc, the average temperature continues to rise (increasing number of hot records, the sea temperature is also rising, the area of glaciers is shrinking dramatically and prolonged drought and flood waters in some places appear. The habitats of plans and animals, routes of bird migration change. The negative effects of extreme weather events thus represent a broad problem area. The effects can be devide into several groups. Some of them have impact already relatively short-term (for

  6. Dynamical Behaviors of Multiple Equilibria in Competitive Neural Networks With Discontinuous Nonmonotonic Piecewise Linear Activation Functions.

    Nie, Xiaobing; Zheng, Wei Xing

    2016-03-01

    This paper addresses the problem of coexistence and dynamical behaviors of multiple equilibria for competitive neural networks. First, a general class of discontinuous nonmonotonic piecewise linear activation functions is introduced for competitive neural networks. Then based on the fixed point theorem and theory of strict diagonal dominance matrix, it is shown that under some conditions, such n -neuron competitive neural networks can have 5(n) equilibria, among which 3(n) equilibria are locally stable and the others are unstable. More importantly, it is revealed that the neural networks with the discontinuous activation functions introduced in this paper can have both more total equilibria and locally stable equilibria than the ones with other activation functions, such as the continuous Mexican-hat-type activation function and discontinuous two-level activation function. Furthermore, the 3(n) locally stable equilibria given in this paper are located in not only saturated regions, but also unsaturated regions, which is different from the existing results on multistability of neural networks with multiple level activation functions. A simulation example is provided to illustrate and validate the theoretical findings. PMID:25826814

  7. Lack of dependence on p53 for DNA double strand break repair of episomal vectors in human lymphoblasts

    Kohli, M.; Jorgensen, T. J.

    1999-01-01

    The p53 tumor suppressor gene has been shown to be involved in a variety of repair processes, and recent findings have suggested that p53 may be involved in DNA double strand break repair in irradiated cells. The role of p53 in DNA double strand break repair, however, has not been fully investigated. In this study, we have constructed a novel Epstein-Barr virus (EBV)-based shuttle vector, designated as pZEBNA, to explore the influence of p53 on DNA strand break repair in human lymphoblasts, since EBV-based vectors do not inactivate the p53 pathway. We have compared plasmid survival of irradiated, restriction enzyme linearized, and calf intestinal alkaline phosphatase (CIP)-treated pZEBNA with a Simian virus 40 (SV40)-based shuttle vector, pZ189, in TK6 (wild-type p53) and WTK1 (mutant p53) lymphoblasts and determined that p53 does not modulate DNA double strand break repair in these cell lines. Copyright 1999 Academic Press.

  8. Close sequence identity between ribosomal DNA episomes of the non-pathogenic Entamoeba dispar and pathogenic Entamoeba histolytica

    Jaishree Paul; Alok Bhattacharya; Sudha Bhattacharya

    2002-11-01

    Entamoeba dispar and Entamoeba histolytica are now recognized as two distinct species – the former being nonpathogenic to humans. We had earlier studied the organization of ribosomal RNA genes in E. histolytica. Here we report the analysis of ribosomal RNA genes in E. dispar. The rRNA genes of E. dispar, like their counterpart in E. histolytica are located on a circular rDNA molecule. From restriction map analysis, the size of E. dispar rDNA circle was estimated to be 24.4 kb. The size was also confirmed by linearizing the circle with BsaHI, and by limited DNAseI digestion. The restriction map of the E. dispar rDNA circle showed close similarity to EhR1, the rDNA circle of E. histolytica strain HM-1:IMSS which has two rDNA units per circle. The various families of short tandem repeats found in the upstream and downstream intergenic spacers (IGS) of EhR1 were also present in E. dispar. Partial sequencing of the cloned fragments of E. dispar rDNA and comparison with EhR1 revealed only 2.6% to 3.8% sequence divergence in the IGS. The region Tr and the adjoining PvuI repeats in the IGS of EhR1, which are missing in those E. histolytica strains that have one rDNA unit per circle, were present in the E. dispar rDNA circle. Such close similarity in the overall organization and sequence of the IGS of rDNAs of two different species is uncommon. In fact the spacer sequences were only slightly more divergent than the 18S rRNA gene sequence which differs by 1.6% in the two species. The most divergent sequence between E. histolytica and E. dispar was the internal transcribed spacer, ITS2. Therefore, it was concluded that probes derived from the ITS1 and ITS2 sequences would be more reliable and reproducible than probes from the IGS regions used earlier for identifying these species.

  9. Expresión episomal de toxina de pertussis genéticamente inactivada en Bordetella pertussis

    Ernesto Marcos

    2010-01-01

    Full Text Available Bordetella pertussis es una bacteria Gram negativa, la cual constituye el agente etiologico de la tos ferina. La enfermedad se desencadena por el efecto conjunto de una serie de factores de virulencia expresados por la bacteria, los cuales se encuentran regulados por el sistema bvg. Uno de los factores de virulencia mas importantes es la toxina de pertussis, razon por la cual, se emplea de forma inactivada como el componente principal de las vacunas acelulares contra la enfermedad. La toxina de pertussis posee una estructura del tipo A-B compuesta por seis polipeptidos codificados en un operon unico. El polipeptido S1 constituye la subunidad enzimaticamente activa, la cual cataliza la transferencia de ADP-ribosa del NAD a la subunidad ALPHA de las proteinas G en celulas eucariotas, lo cual genera una serie de efectos biologicos dentro de los que se incluye: sensibilizacion a histamina, incremento de la secrecion de insulina y efectos inmunoestimuladores e inmunosupresores. El presente trabajo describe los procedimientos realizados para la obtencion de cepas de Bordetella pertussis productoras de elevadas concentraciones de toxina pertusica atenuada geneticamente. Para esto, se realizaron las sustituciones aminoacidicas Arg9 por Lys y Glu129 por Gly de la subunidad S1. El operon de la toxina de pertussis mutada se clono en un vector de amplio rango de hospedero bajo la regulacion de un promotor de expresion temprana (fhaB. Los clones obtenidos pudieran ser empleados como sistemas de expresion para produccion de vacunas acelulares en Cuba.

  10. Genetic Modification of Cancer Cells Using Non-Viral, Episomal S/MAR Vectors for In Vivo Tumour Modelling

    Orestis Argyros; Suet Ping Wong; Kate Gowers; Richard Paul Harbottle

    2012-01-01

    The development of genetically marked animal tumour xenografts is an area of ongoing research to enable easier and more reliable testing of cancer therapies. Genetically marked tumour models have a number of advantages over conventional tumour models, including the easy longitudinal monitoring of therapies and the reduced number of animals needed for trials. Several different methods have been used in previous studies to mark tumours genetically, however all have limitations, such as genotoxi...

  11. Activation of tachykinin, neurokinin 3 receptors affects chromatin structure and gene expression by means of histone acetylation.

    Thakar, Amit; Sylar, Elise; Flynn, Francis W

    2012-12-01

    The tachykinin, neurokinin 3 receptor (NK3R) is a g-protein coupled receptor that is broadly distributed in the nervous system and exerts its diverse physiological actions through multiple signaling pathways. Despite the role of the receptor system in a range of biological functions, the effects of NK3R activation on chromatin dynamics and gene expression have received limited attention. The present work determined the effects of senktide, a selective NK3R agonist, on chromatin organization, acetylation, and gene expression, using qRT-PCR, in a hypothalamic cell line (CLU 209) that expresses the NK3R. Senktide (1 nM, 10nM) caused a relaxation of chromatin, an increase in global acetylation of histone H3 and H4, and an increase in the expression of a common set of genes involved in cell signaling, cell growth, and synaptic plasticity. Pretreatment with histone acetyltransferase (HAT) inhibitor (garcinol and 2-methylene y-butylactone), that inhibits p300, p300/CREB binding protein (CBP) associated factor (PCAF), and GCN 5, prevented the senktide-induced increase in expression of most, but not all, of the genes upregulated in response to 1 nM and 10nM senktide. Treatment with 100 nM had the opposite effect: a reduction in chromatin relaxation and decreased acetylation. The expression of four genes was significantly decreased and the HAT inhibitor had a limited effect in blocking the upregulation of genes in response to 100 nM senktide. Activation of the NK3R appears to recruit multiple pathways, including acetylation, and possibly histone deactylases, histone methylases, or DNA methylases to affect chromatin structure and gene expression. PMID:22985858

  12. Mechanism of p300 specific histone acetyltransferase inhibition by small molecules.

    Arif, M; Pradhan, Suman Kalyan; Thanuja, G R; Vedamurthy, B M; Agrawal, Shipra; Dasgupta, Dipak; Kundu, Tapas K

    2009-01-22

    Dysfunction of histone acetyltransferases (HATs) leads to several diseases including cancer, diabetes, and asthma. Therefore, small molecule inhibitors and activators of HATs are being considered as new generation therapeutics. Here, we report the molecular mechanisms of p300 HAT inhibition by specific and nonspecific HAT inhibitors: garcinol, isogarcinol, and 1 (LTK14). The p300 specific HAT inhibitor 1 behaves as a noncompetitive inhibitor for both acetyl-CoA and histone, unlike nonspecific HAT inhibitors garcinol and isogarcinol. The isothermal calorimetric data suggest that there is a high affinity enthalpy driven single binding site for 1 on p300HAT domain in contrast to two binding sites for garcinol and isogarcinol. Furthermore, the precise nature of molecular interactions was determined by using fluorescence, docking, and mutational studies. On the basis of these observations, we have proposed the mechanisms of specific versus nonspecific HAT inhibition by these small molecule compounds, which may be useful to design therapeutically favorable HAT inhibitors. PMID:19086895

  13. Physical activity

    Physical activity -- which includes an active lifestyle and routine exercise -- plus eating well, is the best way to ... shortness of breath when you are active Build physical activity into your regular routine Simple lifestyle changes can ...

  14. Census taking in the hat: FRW/CFT duality

    In this paper a holographic description of eternal inflation is developed. We focus on the description of an open Friedmann-Robertson-Walker (FRW) universe that results from a tunneling event in which a false vacuum with positive vacuum energy decays to a supersymmetric vacuum with vanishing cosmological constant. The observations of a 'census taker' in the final vacuum can be organized into a holographic dual conformal field theory that lives on the asymptotic boundary of space. We refer to this bulk-boundary correspondence as FRW/CFT duality. The dual conformal field theory (CFT) is a Euclidean two-dimensional theory that includes a Liouville 2D gravity sector describing geometric fluctuations of the boundary. The renormalization-group flow of the theory is richer than in the AdS/CFT correspondence, and generates two space-time dimensions--one spacelike and one timelike. We discuss a number of phenomena such as bubble collisions, and the Garriga, Guth Vilenkin 'persistence of memory', from the dual viewpoint.

  15. hat Does the Rise in RMB Interest Rates Signify?

    SUIJIANXIONG; LIWUZHOU

    2005-01-01

    ON October 28, 2004,the People's Bank ofChina took a U-turn and, after almost a decade of reductions, announced a 0.27 percent increase in RMB interest rates. This superficially inconsequential rise caused quite a stir on the international market. Mining stock plummeted,as did the prices of metals and crude oil futures. This reflexive investor response is just one indication that the Chinese economy has become a major driving force for global economic growth. Its huge demand has sustained high prices for oil and other staple commodities on the international market, international speculators itch to pour their hot money into China, and overseas investors too see it as a potential Klondike.

  16. Welche Germanistik(en) hat/haben Überlebenschancen?

    Colliander, Peter

    verschiedenen Foren an den Diskussionen über mögliche Lösungen dieser Krise und über die Zukunftsperspektiven der Auslandsgermanistik teilgenommen. In meinem Beitrag werde ich versuchen, eine Art Bilanz zu ziehen, die eher den Ernst der Situation betonen als einen naiven „es-wird-schon-gehen-Optimismus“ zum...

  17. Welche Konsequenzen hat Chinas wachsender Einfluss auf die Weltwirtschaft?

    Hermann Remsperger; Markus Taube; Berend Diekmann; Carsten Hermann-Pillath; Rüdiger Ahrend

    2007-01-01

    In den letzten Jahren sind der ökonomische Einfluss und die Bedeutung Chinas enorm gestiegen. Hermann Remsperger, Deutsche Bundesbank, sieht in der stärkeren Integration Chinas in die Weltwirtschaft einen Gewinn, da der globale Wettbewerb zunimmt und dadurch die Produktivität weltweit gefördert wird. Allerdings sei das Land auch ein Mitverursacher von stark gewachsenen Ungleichgewichten. Berend Diekmann, Bundesministerium für Wirtschaft und Technologie, bewertet die Entwicklung ebenfalls posi...

  18. A top hat for Moser's four mathemagical rabbits

    Moree, Pieter

    2010-01-01

    If the equation 1^k+2^k+...+(m-2)^k+(m-1)^k=m^k has an integer solution with k>1, then m>10^{10^6}. Leo Moser showed this in 1953 by remarkably elementary methods. His proof rests on four identities he derives separately. It is shown here that Moser's result can be derived from a von Staudt-Clausen type theorem (an easy proof of which is also presented here). In this approach the four identities can be derived uniformly. The mathematical arguments used in the proofs were already available during the lifetime of Lagrange (1736-1813).

  19. Welches Geschlecht hat die Avantgarde? Which gender has the Avantgarde?

    Gertrud Lehnert

    2000-07-01

    Full Text Available Das Buch betrachtet das Theater der französischen und amerikanischen ‚Avantgarde‘ der Moderne und Postmoderne unter dem Aspekt des Geschlechts: Welcher Verfahren bedient sich avantgardistische Kunst, ist avantgardistische Kunst in geschlechtlicher Hinsicht restriktiv, oder ermöglicht sie die subversive feministische oder auch lesbisch-schwule Ausformung spezifischer Formen?In this book the French and American avantgarde theatre of the modern and postmodern period is analysed from aspects of gender. The questions raised are which processes serve to develop avantgarde art, whether avantgarde art is restrictive with regard to gender, or whether it enables a subversive feminist or specific lesbian/gay forms of theatre?

  20. The BlackHat Library for One-Loop Amplitudes

    We present recent next-to-leading order (NLO) results in perturbative QCD obtained using the BLACKHAT software library. We discuss the use of n-tuples to separate the lengthy matrix-element computations from the analysis process. The use of n-tuples allows many analyses to be carried out on the same phase-space samples, and also allows experimenters to conduct their own analyses using the original NLO computation

  1. Computer Security: Join the CERN WhiteHat Challenge!

    Computer Security Team

    2014-01-01

    Over the past couple of months, several CERN users have reported vulnerabilities they have found in computing services and servers running at CERN. All were relevant, many were interesting and a few even surprising. Spotting weaknesses and areas for improvement before malicious people can exploit them is paramount. It helps protect the operation of our accelerators and experiments as well as the reputation of the Organization. Therefore, we would like to express our gratitude to those people for having reported these weaknesses! Great job and well done!   Seizing the opportunity, we would like to reopen the hunt for bugs, vulnerabilities and insecure configurations of CERN applications, websites and devices. You might recall we ran a similar initiative (“Hide & Seek”) in 2012 where we asked you to sift through CERN’s webpages and send us those that hold sensitive and confidential information. Quite a number of juicy documents were found and subsequently remov...

  2. Welche Auswirkungen hat Basel III auf die Immobilienfinanzierung in Europa?

    Schindler, Felix; Steininger, Bertram

    2012-01-01

    Voraussichtlich zum 1. Januar 2013 beginnt die Implementierungsphase von Basel III, der zweiten Überarbeitung des Basler Akkords zur Regulierung der Kreditinstitute in der Europäischen Union. Mit der ersten Überarbeitung wurde 2004 eine vermeintlich genauer an die tatsächlichen Risiken angepasste Eigenkapitalunterlegung vorgenommen.

  3. Hat der ökologische Landbau in Europa eine Zukunft?

    Offermann, Frank; Nieberg, Hiltrud

    2002-01-01

    Organic farming in Europe has increased rapidly since the early 1990s but still only accounts for a small share of production. This article analyses the structure and financial performance of organic farming in Europe using data from 18 countries. In the countries analysed, organic farms achieved significant price preniia for their outputs and were able to compete financially with conventional farms, with equal or higher profits in most cases, even though yields were up to 40 per cent lower. ...

  4. Orta hat asimetrileri ve tedavi seçenekleri

    Serpil Çokakoğlu; Ruhi Nalçacı

    2012-01-01

    Nowadays the importance given to facial aesthetic is increasing. The coincidence of facial, maxiller and mandibuler dental midlines is very important requiring facial aesthetic. Midline asymmetries can be seen in form of  dental, skeletal and/or soft tissue asymmetries. In most of cases midline asymmetries accompany with facial asymmetries. Even if the amount of patients with midline asymmetry is not known to be aware of their problems, dental midline dev...

  5. Orta hat asimetrileri ve tedavi seçenekleri

    Çokakoğlu, Serpil; Nalçacı, Ruhi

    2013-01-01

    Nowadays the importance given to facial aesthetic is increasing. The coincidence of facial, maxiller and mandibuler dental midlines is very important requiring facial aesthetic. Midline asymmetries can be seen in form of  dental, skeletal and/or soft tissue asymmetries. In most of cases midline asymmetries accompany with facial asymmetries. Even if the amount of patients with midline asymmetry is not known to be aware of their problems, dental midline deviations observing without facial defor...

  6. Antioxidant mechanism of bilirubin: both HAT and SET are possible

    Bilirubin (BR) plays two extreme roles in physiology, one hand it is a toxic metabolite while at micromolar concentration it acts as antioxidant. It has been observed that hydroxyl, glutathiyl and Linoleic peroxyl radicals abstract hydrogen atom from bilirubin, whereas N3, Br2, CCl3OO, NO2 radicals react via single electron transfer action. Our study demonstrates that oxidation of bilirubin occurs via both hydrogen atom transfer and single electron transfer depending on the nature of the radical. (author)

  7. Welche Bedeutung hat der Logos in der Lateinamerikanischen Philosophie?

    Freiler, Andreas

    2005-01-01

    In diesem Essay möchte ich die Beweggründe und Ansichten einiger lateinamerikanischer Philosophen über den Logos im lateinamerikanischen Verständnis behandeln. Im 20. Jahrhundert kam die Frage auf, ob sich eine lateinamerikanische Philosophie charakterisieren lässt. Die Befreiungsphilosophie in den sechziger und siebziger Jahren spielt in dieser Frage eine besondere Rolle. Die lateinamerikanischen Philosophen Leopoldo Zea, Enrique Dussel, Francisco Miro Quesada, Andres Roig und Alberto Villeg...

  8. Physical activity

    ... this page: //medlineplus.gov/ency/article/001941.htm Physical activity To use the sharing features on this page, please enable JavaScript. Physical activity -- which includes an active lifestyle and routine exercise -- ...

  9. Generation and reactivity of putative support systems, Ce-Al neutral binary oxide nanoclusters: CO oxidation and C–H bond activation

    Both ceria (CeO2) and alumina (Al2O3) are very important catalyst support materials. Neutral binary oxide nanoclusters (NBONCs), CexAlyOz, are generated and detected in the gas phase and their reactivity with carbon monoxide (CO) and butane (C4H10) is studied. The very active species CeAlO4• can react with CO and butane via O atom transfer (OAT) and H atom transfer (HAT), respectively. Other CexAlyOz NBONCs do not show reactivities toward CO and C4H10. The structures, as well as the reactivities, of CexAlyOz NBONCs are studied theoretically employing density functional theory (DFT) calculations. The ground state CeAlO4• NBONC possesses a kite-shaped structure with an OtCeObObAlOt configuration (Ot, terminal oxygen; Ob, bridging oxygen). An unpaired electron is localized on the Ot atom of the AlOt moiety rather than the CeOt moiety: this Ot centered radical moiety plays a very important role for the reactivity of the CeAlO4• NBONC. The reactivities of Ce2O4, CeAlO4•, and Al2O4 toward CO are compared, emphasizing the importance of a spin-localized terminal oxygen for these reactions. Intramolecular charge distributions do not appear to play a role in the reactivities of these neutral clusters, but could be important for charged isoelectronic BONCs. DFT studies show that the reaction of CeAlO4• with C4H10 to form the CeAlO4H•C4H9• encounter complex is barrierless. While HAT processes have been previously characterized for cationic and anionic oxide clusters, the reported study is the first observation of a HAT process supported by a ground state neutral oxide cluster. Mechanisms for catalytic oxidation of CO over surfaces of AlxOy/MmOn or MmOn/AlxOy materials are proposed consistent with the presented experimental and theoretical results

  10. Get Active

    ... feeling the benefits of getting active, such as sleeping better or getting toned. Here are 2 ways to add more activity to your life. Be active for longer each time. If you are walking 3 days a week for 30 minutes, try ...

  11. Characteristics of Relocated Quiet Zones Using Virtual Microphone Algorithm in an Active Headrest System

    Seokhoon Ryu

    2016-01-01

    Full Text Available This study displays theoretical and experimental investigation on the characteristics of the relocated zone of quiet by a virtual microphone (VM based filtered-x LMS (FxLMS algorithm which can be embedded in a real-time digital controller for an active headrest system. The attenuation changes at the relocated zones of quiet by the variation of the distance between the ear and the error microphone are mainly examined. An active headrest system was implemented for the control experiment at a chair and consists of two (left and right secondary loudspeakers, two error microphones, two observer microphones at ear positions in a HATS, and other electronics including a dSPACE 1401 controller. The VM based FxLMS algorithm achieved an attenuation of about 22 dB in the control experiment against a narrowband primary noise by the variation of the distance between the ear and the error microphone. The important factors for the algorithm are discussed as well.

  12. Thermal activation of building construction: possibility also in building reconstructions; Thermische Bauteilaktivierung auch bei Bauwerksanierungen

    Glueck, B. [TGA Joessnitz (Plauen) (Germany)

    2002-04-01

    The thermal activation of concrete ceilings, also concrete called core activation, is getting a large spread in the last years. Since the water tubing registers must be brought in during the concreting process, this technology is not applicable in the case of reconstructions. To be able to use the energetic advantages - which occur with the use of water temperatures near room temperature, also within the construction area, there is a set of suggestions. A version, which includes even the storage in the available concrete ceilings, is examined in consideration of is efficiency. (orig.) [German] Die thermische Bauteilaktivierung von Massivdecken - auch Betonkernaktivierung genannt - hat in den letzten Jahren eine grosse Verbreitung erfahren. Da die wasserdurchflossenen Rohrregister waehrend des Betoniervorgangs eingebracht werden muessen, ist diese Technologie im Sanierungsfall nicht anwendbar. Um die energetischen Vorteile - die beim Einsatz von raumnahen Wassertemperaturen auftreten - auch im Sanierungsbereich nutzbar zu machen, gibt es eine Reihe von Vorschlaegen. Eine Variante, die sogar die Speicherung von vorhandenen Massivdecken einbezieht, wird auf ihre Leistungsfaehigkeit untersucht. (orig.)

  13. Activation analysis

    The neutron activation analysis, which appears to be in limits for further advance, is the most suitable for providing information on the principal as well as the microcomponents in any sample of solid form. Then, instrumental activation analysis is capable of determination of far many elements in various samples. Principally on the neutron activation analysis, the following are described in literature survey from 1982 to middle 1984: bibliography, review, data collection, etc.; problems in spectral analysis and measurement; activation analysis with neutrons; charged particle and photo-nucleus reactions; chemical separation, isotopic dilution activation analysis; molecular activation analysis; standard materials; life and its relation samples; environmental, food, court trial and archaeological samples; space and earth sciences. (Mori, K.)

  14. Active ratchets

    Angelani, L.; Costanzo, A.; Di Leonardo, R.

    2011-12-01

    We analyze self-propelling organisms, or active particles, in a periodic asymmetric potential. Unlike standard ratchet effect for Brownian particles requiring external forcing, in the case of active particles asymmetric potential alone produces a net drift speed (active ratchet effect). By using theoretical models and numerical simulations we demonstrate the emergence of the rectification process in the presence of an asymmetric piecewise periodic potential. The broken spatial symmetry (external potential) and time symmetry (active particles) are sufficient ingredients to sustain unidirectional transport. Our findings open the way to new mechanisms to move in directional manner motile organisms by using external periodic static fields.

  15. Physical Activity

    Andersen, Lars Bo; Anderssen, Sigmund Alfred; Wisløff, Ulrik;

    2014-01-01

    Andersen LB, Anderssen SA, Wisløff U, Hellénius M-L, Fogelholm M, Ekelund U. (Expert Group) Nordic Nutrition Recommendations 2012. Integrating nutrition and physical activity. Chapter: Physical Activity p. 195-217.Nordic Counsil of Ministers.......Andersen LB, Anderssen SA, Wisløff U, Hellénius M-L, Fogelholm M, Ekelund U. (Expert Group) Nordic Nutrition Recommendations 2012. Integrating nutrition and physical activity. Chapter: Physical Activity p. 195-217.Nordic Counsil of Ministers....

  16. Activity report

    The Department of Physics and Measurement Technology, Biology and Chemistry (IFM) presents every year a progress report containing a brief description of activities in research and education within the department. The report is intended as an information for colleagues and institutions. The present report contains activities for the academic year July 1989 to June 1990

  17. Indoor Activities

    ... so you can do some lifting while you watch TV. Walk around the house when you talk on the phone. Make an extra trip up and down the stairs when you do the laundry. Download the Tip Sheet Indoor Activities (PDF, 739.53 KB) You Might Also Like Sun Safety Have Fun. Be Active with Your Dog! ...

  18. Activated Charcoal

    ... reduce intestinal gas (flatulence), lower cholesterol levels, prevent hangover, and treat bile flow problems (cholestasis) during pregnancy. ... pregnancy, according to some early research reports. Preventing hangover. Activated charcoal is included in some hangover remedies, ...

  19. Active Galaxies

    Kilerci Eser, Ece

    Galaxy formation and evolution is one of the main research themes of modern astronomy. Active galaxies such as Active Galactic Nuclei (AGN) and Ultraluminous Infrared Galaxies (ULIRGs) are important evolutionary stages of galaxies. The ULIRG stage is mostly associated with galaxy mergers and...... interactions. During the interactions of gas-rich galaxies, the gas inflows towards the centers of the galaxies and can trigger both star formation and AGN activity. The ULIRG stage includes rapid star formation activity and fast black hole growth that is enshrouded by dust. Once the AGN emission is...... one is related to the mass estimates of supermassive black holes (SMBHs). Mass estimates of SMBHs are important to understand the formation and evolution of SMBHs and their host galaxies. Black hole masses in Type 1 AGN are measured with the reverberation mapping (RM) technique. Reverberation mapping...

  20. LDEF (Flight), S0050 : Investigation of the Effects of Long-Duration Exposure on Active Optical Syst

    1990-01-01

    LDEF (Flight), S0050 : Investigation of the Effects of Long-Duration Exposure on Active Optical System Components, Tray E05 The flight photograph was taken from the Orbiter aft flight deck during the LDEF retrieval and prior to berthing the LDEF in the Orbiter cargo bay. The Active Optical System Component Experiment (S0050) contained 136 test specimen located in a six (6) inch deep LDEF peripheral experiment tray. The complement of specimen included optical and electro-optical components, glasses and samples of various surface finishes. The experiment tray was divided into six sections, each consisting of a 1/4 inch thick chromic anodized aluminum base plate and a 1/16th inch thick aluminum hat-shaped structure for mounting the test specimens. The test specimens were typically placed in fiberglass-epoxy retainer strip assemblies prior to installation on the hat-shaped mounting structure. Five of the six sections were covered by a 1/8 inch thick anodized aluminum sun screen with openings that allowed 56 percent transmission over the central region. Two sub-experiments, The Optical Materials and UV Detectors Experiment (S0050-01) consist of 15 optical windows, filters and detectors and occupies one of the trays six sub-sections and The Optical Substrates and Coatings Experiment (S0050-02 ) that includes 12 substrates and coatings and two secondary experiments,The Holographic Data Storage Experiment (AO044) consisting of four crystals of lithium niobate and ThePyroelectric Infrared Detectors Experiment (AO135) with twenty detectors, are also mounted in the integrated tray. The experiment structure was assembled with non-magnetic stainless steel fasteners. The experiment hardware appears to be intact with no apparent damage. The excess blue color in the photograph makes a detailed assessment of color changes difficult. The paint dots on the tray clamp blocks, initially white, appear to have darkened and tray flanges appear discolored. The experiment sun screens and

  1. Active colloids

    Aranson, Igor S.

    2013-01-01

    A colloidal suspension is a heterogeneous fluid containing solid microscopic particles. Colloids play an important role in our everyday life, from food and pharmaceutical industries to medicine and nanotechnology. It is useful to distinguish two major classes of colloidal suspensions: equilibrium and active, i.e., maintained out of thermodynamic equilibrium by external electric or magnetic fields, light, chemical reactions, or hydrodynamic shear flow. While the properties of equilibrium colloidal suspensions are fairly well understood, active colloids pose a formidable challenge, and the research is in its early exploratory stage. One of the most remarkable properties of active colloids is the possibility of dynamic self-assembly, a natural tendency of simple building blocks to organize into complex functional architectures. Examples range from tunable, self-healing colloidal crystals and membranes to self-assembled microswimmers and robots. Active colloidal suspensions may exhibit material properties not present in their equilibrium counterparts, e.g., reduced viscosity and enhanced self-diffusivity, etc. This study surveys the most recent developments in the physics of active colloids, both in synthetic and living systems, with the aim of elucidation of the fundamental physical mechanisms governing self-assembly and collective behavior.

  2. Physics activities

    As we move into the 21st Century, nuclear technology is on the verge of rejuvenation in advanced Member States and of expansion in developing Member States. The principal responsibilities of the IAEA are transferring technologies, co-ordinating scientific research, managing specialized projects and maintaining analytical quality control. The IAEA physics activities provide assistance with nuclear instrumentation, promote more effective utilization of research reactors and accelerators, and facilitate global co-operation in nuclear fusion research. These activities will help Member States improve their standards of living through the benefits of nuclear technology. This booklet presents a brief profile on the physics activities and involvement in these fields of the Physics Section, IAEA

  3. Protease activated receptor signaling is required for African trypanosome traversal of human brain microvascular endothelial cells.

    Dennis J Grab

    Full Text Available BACKGROUND: Using human brain microvascular endothelial cells (HBMECs as an in vitro model for how African trypanosomes cross the human blood-brain barrier (BBB we recently reported that the parasites cross the BBB by generating calcium activation signals in HBMECs through the activity of parasite cysteine proteases, particularly cathepsin L (brucipain. In the current study, we examined the possible role of a class of protease stimulated HBMEC G protein coupled receptors (GPCRs known as protease activated receptors (PARs that might be implicated in calcium signaling by African trypanosomes. METHODOLOGY/PRINCIPAL FINDINGS: Using RNA interference (RNAi we found that in vitro PAR-2 gene (F2RL1 expression in HBMEC monolayers could be reduced by over 95%. We also found that the ability of Trypanosoma brucei rhodesiense to cross F2RL1-silenced HBMEC monolayers was reduced (39%-49% and that HBMECs silenced for F2RL1 maintained control levels of barrier function in the presence of the parasite. Consistent with the role of PAR-2, we found that HBMEC barrier function was also maintained after blockade of Galpha(q with Pasteurella multocida toxin (PMT. PAR-2 signaling has been shown in other systems to have neuroinflammatory and neuroprotective roles and our data implicate a role for proteases (i.e. brucipain and PAR-2 in African trypanosome/HBMEC interactions. Using gene-profiling methods to interrogate candidate HBMEC pathways specifically triggered by brucipain, several pathways that potentially link some pathophysiologic processes associated with CNS HAT were identified. CONCLUSIONS/SIGNIFICANCE: Together, the data support a role, in part, for GPCRs as molecular targets for parasite proteases that lead to the activation of Galpha(q-mediated calcium signaling. The consequence of these events is predicted to be increased permeability of the BBB to parasite transmigration and the initiation of neuroinflammation, events precursory to CNS disease.

  4. Regulatory activities

    This publication, compiled in 8 chapters, presents the regulatory system developed by the Nuclear Regulatory Authority (NRA) of the Argentine Republic. The following activities and developed topics in this document describe: the evolution of the nuclear regulatory activity in Argentina; the Argentine regulatory system; the nuclear regulatory laws and standards; the inspection and safeguards of nuclear facilities; the emergency systems; the environmental systems; the environmental monitoring; the analysis laboratories on physical and biological dosimetry, prenatal irradiation, internal irradiation, radiation measurements, detection techniques on nuclear testing, medical program on radiation protection; the institutional relations with national and international organization; the training courses and meeting; the technical information

  5. Active house

    Eriksen, Kurt Emil; Olesen, Gitte Gylling Hammershøj

    2010-01-01

    Formålet med dette abstrakt er at illustrere, at huse kan være konstrueret til at basere sig udelukkende på vedvarende energikilder og samtidig være CO2-neutrale og producere mere energi end de forbruger. Active House Visionen undersøger disse muligheder i otte demonstration huse i fem forskellige...

  6. Activated Sludge.

    Saunders, F. Michael

    1978-01-01

    Presents the 1978 literature review of wastewater treatment. This review covers: (1) activated sludge process; (2) process control; (3) oxygen uptake and transfer; (4) phosphorus removal; (5) nitrification; (6) industrial wastewater; and (7) aerobic digestion. A list of 136 references is also presented. (HM)

  7. Activity report

    Yu, S W

    2008-08-11

    This report is aimed to show the author's activities to support the LDRD. The title is 'Investigation of the Double-C Behavior in the Pu-Ga Time-Temperature-Transformation Diagram' The sections are: (1) Sample Holder Test; (2) Calculation of x-ray diffraction patterns; (3) Literature search and preparing publications; (4) Tasks Required for APS Experiments; and (5) Communications.

  8. Digital Activism

    Skovgaard Jørgensen, Emma; Debiteh Dimma Nielsen, Cecilie

    2015-01-01

    This paper examines the phenomenon of digital activism an how it challenges political systems in transition to democracy. As theoretical framework we will use concepts within sociology and political science as analytical tools to our case studies of China and Egypt, in order to find out which role the different concepts play in each case and how these interrelate with one and other. The project was analyzed from a structuralist interpretive approach, viewing social reality as a practice ...

  9. Hepatoprotective Activity.

    2016-01-01

    The liver performs a vital role in metabolism, secretion, storage, and detoxification of endogenous and exogenous substances. Oxidative stress and free radicals enhance the severity of hepatic damage, which can be overcome by the antioxidant mechanism. Plant extracts can be the best source of such antioxidants and mediate hepatoprotective activity. In this chapter, high-dose paracetamol-induced hepatotoxicity in rat model is discussed with explanations of biochemical and histopathological studies. PMID:26939279

  10. Chocolate active

    There is a table of current radioactivity values for various foods and mushrooms. A special accent is on milk and chocolate. Chocolate sorts with more powdered milk are more active. Finally there is a chapter on radionucleides contained in the Chernobyl fallout, other than cesium 137, cesium 134 and strontium 90. The amounts of ruthenium 106, antimony 125, cerium 144, silver 110 m, cesium 134, strontium 90 and plutonium 239 relative to cesium 137 in soil samples in autumn 1987 are given. Special emphasis is on ruthenium 'hot particles' and on plutonium. (qui)

  11. Halal Activism

    Fischer, Johan

    2016-01-01

    The purpose of this article is to further our understanding of contemporary Muslim consumer activism in Malaysia with a particular focus on halal (in Arabic, literally “permissible” or “lawful”) products and services. Muslim activists and organisations promote halal on a big scale in the interface...... particular historical/national settings and that these issues should be explored in the interfaces between Islam, the state and market. More specifically, this article examines the above issues building on ethnography from fieldwork with three Muslim organisations in Malaysia....

  12. Activating schoolyards

    Andersen, Henriette Bondo; Pawlowski, Charlotte Skau; Scheller, Hanne Bebendorf;

    2015-01-01

    objectively determine where and how active the students are in the schoolyard, before and after the intervention. This provides a type of data that, to our knowledge, has not been used before in schoolyard interventions. Exploring the change in behavior in relation to specific intervention elements in the...... accelerometer, GPS and GIS; 3) a process evaluation facilitating the intervention development process and identifying barriers and facilitators in the implementation process; 4) a post-intervention end-user evaluation aimed at exploring who uses the schoolyards and how the schoolyards are used. The seven...

  13. Active packaging with antifungal activities.

    Nguyen Van Long, N; Joly, Catherine; Dantigny, Philippe

    2016-03-01

    There have been many reviews concerned with antimicrobial food packaging, and with the use of antifungal compounds, but none provided an exhaustive picture of the applications of active packaging to control fungal spoilage. Very recently, many studies have been done in these fields, therefore it is timely to review this topic. This article examines the effects of essential oils, preservatives, natural products, chemical fungicides, nanoparticles coated to different films, and chitosan in vitro on the growth of moulds, but also in vivo on the mould free shelf-life of bread, cheese, and fresh fruits and vegetables. A short section is also dedicated to yeasts. All the applications are described from a microbiological point of view, and these were sorted depending on the name of the species. Methods and results obtained are discussed. Essential oils and preservatives were ranked by increased efficacy on mould growth. For all the tested molecules, Penicillium species were shown more sensitive than Aspergillus species. However, comparison between the results was difficult because it appeared that the efficiency of active packaging depended greatly on the environmental factors of food such as water activity, pH, temperature, NaCl concentration, the nature, the size, and the mode of application of the films, in addition to the fact that the amount of released antifungal compounds was not constant with time. PMID:26803804

  14. Raman and surface enhanced Raman spectroscopic studies of specific, small molecule activator of histone acetyltransferase p300

    Kundu, Partha P.; Pavan Kumar, G. V.; Mantelingu, Kempegowda; Kundu, Tapas K.; Narayana, Chandrabhas

    2011-07-01

    We report for the first time, the Raman and surface enhanced Raman scattering (SERS) studies of N-(4-chloro-3-trifluoromethyl-phenyl)-2-ethoxy-benzamide (CTB). This molecule is specific activator of human histone acetyltransferase (HAT), p300, and serves as lead molecule to design anti-neoplastic therapeutics. A detailed Raman and SERS band assignments have been performed for CTB, which are compared with the density functional theory calculations. The observed red shift of N sbnd H stretching frequency from the computed wavenumber indicates the weakening of N sbnd H bond resulting from proton transfer to the neighboring oxygen atom. We observe Ag sbnd N vibrational mode at 234 cm -1 in SERS of CTB. This indicates there is a metal-molecule bond leading to chemical enhancement in SERS. We also observe, enhancement in the modes pertaining to substituted benzene rings and methyl groups. Based on SERS analysis we propose the adsorption sites and the orientation of CTB on silver surface.

  15. Evidence That the Enterotoxin Gene Can Be Episomal in Clostridium perfringens Isolates Associated with Non-Food-Borne Human Gastrointestinal Diseases

    Collie, Renee E.; McClane, Bruce A.

    1998-01-01

    Clostridium perfringens enterotoxin (CPE) is responsible for the diarrheal and cramping symptoms of human C. perfringens type A food poisoning. CPE-producing C. perfringens isolates have also recently been associated with several non-food-borne human gastrointestinal (GI) illnesses, including antibiotic-associated diarrhea and sporadic diarrhea. The current study has used restriction fragment length polymorphism (RFLP) and pulsed-field gel electrophoresis (PFGE) analyses to compare the genoty...

  16. Identification of Episomal Human Papillomavirus and Other DNA Viruses in Cytological Anal Samples of HIV-Uninfected Men Who Have Sex with Men

    Donà, Maria Gabriella; Paolini, Francesca; Benevolo, Maria; Vocaturo, Amina; Latini, Alessandra; Giglio, Amalia; Venuti, Aldo; Giuliani, Massimo

    2013-01-01

    To date, there have been only few studies that investigated integration of anal Human Papillomavirus (HPV). Most of them were conducted on HIV-infected individuals and mainly analyzed samples from high-grade lesions and invasive cancer. We aimed to investigate HPV physical status in HIV-negative men who have sex with men (MSM) with a detectable anal HPV infection, irrespective of the presence of lesions. We also sought to explore the presence of other circular DNA viruses in the anal region. ...

  17. MAR介导的非病毒附着体载体的研究进展%Research Progress of the Matrix Attachment Mediated Nonvirus Episomal Vector

    林艳; 李照熙; 王芳; 王天云

    2012-01-01

    附着体载体可以使外源基因在宿主细胞中不整合到基因组上而是以附着体的形式存在,是一种新型的高效、安全、附着体表达载体.目前研究较多的是由S/MAR(Scaffold/Matrix Attachment Region,S/MAR)元件介导的质粒.虽然此类载体均能介导载体附着存在,但是转基因的表达量不同.最近研究发现,载体的启动子、骨架结构、CpG基序以及表达系统等方面能够影响转基因的表达,针对以上内容作一综述,希望据此进一步优化载体,为临床研究提供基础依据.

  18. Active sharing

    2012-01-01

    The big news this week is, of course, the conclusions from the LHC performance workshop held in Chamonix from 6 to 10 February . The main recommendation, endorsed by CERN’s Machine Advisory Committee and adopted by the Management, is that the LHC will run at 4 TeV per beam this year. You can find all the details from Chamonix in the slides presented on Wednesday at the summary session, which leaves me free to talk about another important development coming up soon.   In ten days time, a new kind of gathering will be taking place in Geneva, bringing together two previously separate conferences, one driven by physics, the other by the medical community, but both looking to apply physics to the advancement of health. The merger of the International Conference for Translational Research in Radio-Oncology and CERN’s workshop on Physics for Health in Europe (ICTR-PHE) makes for a very eclectic mix. Presentations range from active shielding for interplanetary flight to the rather...

  19. Thanatos-associated protein 7 associates with template activating factor-Ibeta and inhibits histone acetylation to repress transcription.

    Macfarlan, Todd; Parker, J Brandon; Nagata, Kyosuke; Chakravarti, Debabrata

    2006-02-01

    The posttranslational modifications of histones on chromatin or a lack thereof is critical in transcriptional regulation. Emerging studies indicate a role for histone-binding proteins in transcriptional activation and repression. We have previously identified template-activating factor-Ibeta (TAF-Ibeta, also called PHAPII, SET, and I(2)(pp2A)) as a component of a cellular complex called inhibitor of acetyltransferases (INHAT) that masks histone acetylation in vitro and blocks histone acetyltransferase (HAT)-dependent transcription in living cells. TAF-Ibeta has also been shown to associate with transcription factors, including nuclear receptors, to regulate their activities. To identify novel interactors of TAF-Ibeta, we employed a yeast two-hybrid screen and identified a previously uncharacterized human protein called thanatos-associated protein-7 (THAP7), a member of a large family of THAP domain-containing putative DNA-binding proteins. In this study we demonstrate that THAP7 associates with TAF-Ibeta in vitro and map their association domains to a C-terminal predicted coiled-coil motif on THAP7 and the central region of TAF-Ibeta. Similarly, stably transfected THAP7 associates with endogenous TAF-Ibeta in intact cells. Like TAF-Ibeta, THAP7 associates with histone H3 and histone H4 and inhibits histone acetylation. The histone-interacting domain of THAP7 is sufficient for this activity in vitro. Promoter-targeted THAP7 can also recruit TAF-Ibeta and silencing mediator of retinoid and thyroid receptors/nuclear hormone receptor corepressor (NCoR) proteins to promoters, and knockdown of TAF-Ibeta by small interfering RNA relieves THAP7-mediated repression, indicating that, like nuclear hormone receptors, THAP7 may represent a novel class of transcription factor that uses TAF-Ibeta as a corepressor to maintain histones in a hypoacetylated, repressed state. PMID:16195249

  20. Familial aggregation of Trypanosoma brucei gambiense trypanosomiasis in a very high incidence community in Zaire.

    Khonde, N; Pépin, J; Niyonsenga, T; De Wals, P

    1997-01-01

    Familial aggregation of Trypanosoma brucei gambiense human African trypanosomiasis (HAT) was investigated in 3 adjacent villages of central Zaire where 318/1431 inhabitants had previously suffered from HAT. Neither spatial nor familial aggregation was detected when analysing the distribution of cases in the whole community using Poisson, negative binomial and pairwise odds ratio models. However, clustering of cases was observed when specific familial relationships were examined. The risk of HAT for a child was significantly increased if the mother had also had HAT, but it was not influenced by a past history of HAT in the father. Sisters and brothers of cases of HAT had a higher risk of HAT than siblings of individuals who had never had HAT, but no such association was documented for half-sisters and half-brothers. Among married couples, a past history of HAT in one spouse had no impact on the other spouse's risk of HAT. Indirect arguments suggested that familial clustering was a consequence of shared exposure, either sequential or simultaneous, rather than of genetic susceptibility. The existence of familial clustering should be kept in mind when implementing passive or active case-finding activities. PMID:9463655

  1. IASS Activity

    Hojaev, Alisher S.; Ibragimova, Elvira M.

    2015-08-01

    It’s well known, astronomy in Uzbekistan has ancient roots and traditions (e.g., Mirzo Ulugh Beg, Abū al-Rayhān al-Bīrūnī, Abū ‘Abdallāh al-Khwārizmī) and astronomical heritage carefully preserved. Nowadays uzbek astronomers play a key role in scientific research but also in OAD and Decadal Plan activity in the Central Asia region. International Aerospace School (IASS) is an amazing and wonderful event held annually about 30 years. IASS is unique project in the region, and at the beginning we spent the Summer and Winter Schools. At present in the summer camp we gather about 50 teenage and undergraduate students over the country and abroad (France, Malaysia, Turkey, Azerbaijan, Pakistan, Russia, etc.). They are selected on the basis of tests of astronomy and space issues. During two weeks of IASS camp the invited scientists, cosmonauts and astronauts as well as other specialists give lectures and engage in practical exercises with IASS students in astronomy, including daily observations of the Sun and night sky observations with meniscus telescope, space research and exploration, aerospace modelling, preparation and presentation of original projects. This is important that IASS gives not theoretical grounds only but also practically train the students and the hands-on training is the major aims of IASS. Lectures and practice in the field of astronomy carried out with the direct involvement and generous assistance of Uranoscope Association (Paris, France). The current 26-th IASS is planned to held in July 2015.

  2. Physical Activity (Exercise)

    ... Our ePublications > Physical activity (exercise) fact sheet ePublications Physical activity (exercise) fact sheet How can physical activity improve ... Have had recent hip surgery More information on physical activity (exercise) For more information about physical activity (exercise), ...

  3. Activation Energy

    Gadeken, Owen

    2002-01-01

    Teaming is so common in today's project management environment that most of us assume it comes naturally. We further assume that when presented with meaningful and challenging work, project teams will naturally engage in productive activity to complete their tasks. This assumption is expressed in the simple (but false) equation: Team + Work = Teamwork. Although this equation appears simple and straightforward, it is far from true for most project organizations whose reality is a complex web of institutional norms based on individual achievement and rewards. This is illustrated by the very first successful team experience from my early Air Force career. As a young lieutenant, I was sent to Squadron Officer School, which was the first in the series of Air Force professional military education courses I was required to complete during my career. We were immediately formed into teams of twelve officers. Much of the course featured competition between these teams. As the most junior member of my team, I quickly observed the tremendous pressure to show individual leadership capability. At one point early in the course, almost everyone in our group was vying to become the team leader. This conflict was so intense that it caused us to fail miserably in our first outdoor team building exercise. We spent so much time fighting over leadership that we were unable to complete any of the events on the outdoor obstacle course. This complete lack of success was so disheartening to me that I gave our team little hope for future success. What followed was a very intense period of bickering, conflict, and even shouting matches as our dysfunctional team tried to cope with our early failures and find some way to succeed. British physician and researcher Wilfred Bion (Experiences in Groups, 1961) discovered that there are powerful psychological forces inherent in all groups that divert from accomplishing their primary tasks. To overcome these restraining forces and use the potential

  4. Effects of Supercritical Carbon Dioxide and Sub-critical Propane Extraction of Thyme and Cardamom on Chemical Composition, Antioxidant Capacity and Antimicrobial Properties (Kakukkfű és kardámom szuperkritikus széndioxid és szubkritikus propán extrakciójának hatása az oleoresin kémiai össztételére, antioxidáns kapacitására és antimikrobás tulajdonságára)

    Hamdan, Samer A. N.

    2008-01-01

    Munkám során a szuperkritikus CO2 és szubkritikus propán extrakciónak a kakukkfűből, illetve kardamom magból készült oleoresin összetételére, antioxidáns kapacitására és antimikrobás aktivitására gyakorolt hatását tűztem ki célul. Az extrakciót a Veszprémi Egyetemhez tartozó félüzemi berendezéssel végeztem. A szuperkritikus CO2 extrakciót 80 és 400 baron, 35-55 °C-on, a szuperkritikus propán extrakciót pedig 25-50 baron, 25 °C-on végeztem. Kontrolként a két gyógynövényből kivonatot készítette...

  5. Active sites for methane activation in MgO and Li doped MgO

    Kwapień, Karolina

    2012-01-01

    Die vorliegende Dissertation präsentiert eine detaillierte quantenchemische Untersuchung der H-Abstraktion von Methan durch MgO und Li dotiertes MgO. Motiviert wurde die durch das UniCat-Excellenz-Cluster, welches sich zum Ziel gesetzt hat, die oxidative Kupplung von Methan (OCM) im Detail zu verstehen. Basierend auf der Hypothese, dass Li+O•– Spezies für den H-Abstraktion Schritt verantwortlich sind, wurden kleine kationische MgO- und Li dotierte MgO-Cluster (die O•– Sites modellieren) unt...

  6. Environmental Impact Assessment and Space Activities

    Viikari, L.

    . An obvious problem for any impact assessment are the deficiencies in knowledge about processes taking place in space in general. The outcome of proposed space activities therefore cannot necessarily be assessed in detail. In any case, outer space is a global common, and any adverse environmental effects of space utilization are therefore likely to be highly severe, irreversible and wide in scope. On the other hand, the tragedy of the commons problem render many nationally adopted strategies for combating adverse environmental consequences ineffective. Additionally, some principles applied on earth have not been as warmly welcomed among the space faring nations and other entities involved. For instance, it is still an issue under debate whether space has any intrinsic value or is merely a resource for human utilization. There is presently no permanent human settlement in space, and the environs thereby remain somew hat remote for the everyday lives of the vast majority of humankind. Space industry is, furthermore, highly commercialised and militarised area of international activity. Relevance of the precautionary principle and sustainable development, for instance, seem to rest therefore on a bit shakier ground while applied in outer space. Space faring nations and other entities seldom are very keen on distributing detailed information about their planned activities either. Also the fact that any activity taking place in outer space may be regarded ultra-hazardous, although during their normal operation the environmental harms usually are minor, renders for instance the due diligence principle, and the transboundary impact assessment duty it entails, somewhat less applicable. Nevertheless, sustainable development and precautionary principle are important issues for all space activities, too, and such goals would obviously necessitate better environmental protection. Additionally, democracy would seem to require the possibility of enhanced public participation, or at

  7. ACTIVITY MINING: FROM ACTIVITIES TO ACTIONS

    LONGBING CAO; YANCHANG ZHAO; CHENGQI ZHANG; HUAIFENG ZHANG

    2008-01-01

    Activity data accumulated in real life, such as terrorist activities and governmental customer contacts, present special structural and semantic complexities. Activity data may lead to or be associated with significant business impacts, and result in important actions and decision making leading to business advantage. For instance, a series of terrorist activities may trigger a disaster to society, and large amounts of fraudulent activities in social security programs may result in huge gover...

  8. The role of partnerships in promoting physical activity: the experience of Agita São Paulo.

    Matsudo, Victor

    2012-01-01

    Strategic partnership is a logical approach to face some of the public health problems. However, its application is somewhat more complex. In this paper our experience with three networks (Agita São Paulo, Physical Activity Network of Americas, and Agita Mundo Network) was described. In the case of Agita São Paulo even the name was a consequence of a partnership with a marketing company, and is an idiomatic expression that means much more than just to move your body. It also means to move psychologically and socially, with the concept of "active citizenship". Among the important features of that intervention, we highlighted: (a) national and international intellectual partnership; (b) strong institutional partnerships, including government in one hand, and non-governmental and private sector in the other hand, in a so called: "two-hats approach"; (c) minimal formalization/maximal flexibility; (d) a signed letter of agreement: an active symbol of institutional commitment; (e) use the "mobile management" adaptation of the ecological model, in which attention was given to intrapersonal, social, and physical environmental factors, in a dynamic way; (f) attention to inter-sectoral as well as to intra-sectoral partners, in which creates incentives for participation of more than one representative from each sector; (g) the inclusion principle, that was not restricted to the institution, but affected the program actions, materials, and particularly the messages; (h) a high level of legitimacy of the coordination institution in the leadership; (i) special attention to improve environment supports for physical activity, such as: strategic partnerships established with the Metro System, that serves over 1 million persons/day; the Truck Drivers Radio Station; the State Secretariat of Environment, that built a walking path around its main building; the city of São Caetano do Sul, with the healthy sidewalk program; the city of Santana do Parnaiba building a walking path

  9. An exploratory study on the peroxyl-radical-scavenging activity of 2,6-dimethyl-5-hepten-2-ol and its heterocyclic analogues

    Stobiecka, Agnieszka; Sikora, Magdalena; Bonikowski, Radosław; Kula, Józef

    2016-03-01

    The structural properties and radical scavenging activity of 2,6-dimethyl-5-hepten-2-ol (1) and its new heterocyclic analogues, i.e. 2-methyl-4-(5-methylfuran-2-yl)-butan-2-ol (2) and 2-methyl-4-(5-methylthiophen-2-yl)-butan-2-ol (3) and have been studied by using the experimental and theoretical methods for the first time. Activity of title compounds against the peroxyl radical was determined by using standard fluorimetric test, i.e. the Oxygen Radical Absorbance Capacity assay (ORACFL). Furthermore, the electron-donating ability of odorants has been evaluated by using colorimetric ABTS assay. According to the experimental results obtained from the ORACFL test 2,6-dimethyl-5-hepten-2-ol was characterized by the highest activity in comparison with the novel counterparts. Nevertheless, all investigated compounds exhibited pronounced anti-peroxyl radical activity comparable to that exerted by the one of the most prominent antioxidant among the monoterpene alcohols, i.e. by linalool. On the other hand, the title compounds exerted relatively low capacity to quench the radical cation of ABTS. Theoretical calculations based on the Density Functional Theory (DFT) method with the hybrid functional B3LYP were carried out in order to investigate selected structural and electronic properties including the geometrical parameters as well as the energy of frontier molecular orbitals of parent molecules and the resulting radicals. Furthermore, the possible mechanism of peroxyl-radical-scavenging has been determined by using the thermodynamic descriptors such as the bond dissociation enthalpies (BDEs) and ionization potentials (IPs). These theoretical data pointed out the relevance of HAT mechanism in the peroxyl-radical-scavenging exhibited by 2,6-dimethyl-5-hepten-2-ol and its new heterocyclic analogues in polar and non-polar medium.

  10. Guide to Physical Activity

    ... Families ( We Can! ) Health Professional Resources Guide to Physical Activity Physical activity is an important part of your ... to injury. Examples of moderate-intensity amounts of physical activity Common Chores Washing and waxing a car for ...

  11. Charitable activities in Azerbaijan

    Ismailova Sevil Aydin

    2015-01-01

    In this article, found its proper reflection questions related to the issue of charitable activities in Azerbaijan. Briefly described the history of charitable activities in Azerbaijan. Also shown is the legal framework of charitable activities in Azerbaijan.

  12. Physical Activity Assessment

    Current evidence convincingly indicates that physical activity reduces the risk of colon and breast cancer. Physical activity may also reduce risk of prostate cancer. Scientists are also evaluating potential relationships between physical activity and other cancers.

  13. Bounded Active Perception

    KETENCI, Uktu Gorkem; Bremond, Roland; Auberlet, Jean Michel; GRISLIN, Emmanuelle

    2010-01-01

    There are two kinds of perception : active and passive. This paper is an attempt to take advantage of active perception to improve the agent's perception of relevant information. Through the data filtering capacity, active perception is a useful tool for modeling human-like bounded perception. Using such filters, either the agent or the environment take an active role. We determine several unsolved issues in active perception and do several proposals to implement our concept on the active per...

  14. Political activity for physical activity: health advocacy for active transport

    Amun Qa-t-a

    2011-05-01

    Full Text Available Abstract Effective health advocacy is a priority for efforts to increase population participation in physical activity. Local councils are an important audience for this advocacy. The aim of the current study was to describe features of advocacy for active transport via submissions to city council annual plans in New Zealand, and the impact of an information sheet to encourage the health sector to be involved in this process. Written submissions to city council's annual consultation process were requested for 16 city councils over the period of three years (2007/08, 2008/09, and 2009/10. Submissions were reviewed and categories of responses were created. An advocacy information sheet encouraging health sector participation and summarising some of the evidence-base related to physical activity, active transport and health was released just prior to the 2009/10 submission time. Over the period of the study, city councils received 47,392 submissions, 17% of which were related to active transport. Most submissions came from city residents, with a small proportion (2% from the health sector. The largest category of submissions was in support of pedestrian and cycling infrastructure, design and maintenance of facilities and additional features to support use of these transport modes. Health arguments featured prominently in justifications for active transport initiatives, including concerns about injury risk, obesity, physical inactivity, personal safety and facilities for people with disabilities. There was evidence that the information sheet was utilised by some health sector submitters (12.5%, providing tentative support for initiatives of this nature. In conclusion, the study provides novel information about the current nature of health advocacy for active transport and informs future advocacy efforts about areas for emphasis, such as health benefits of active transport, and potential alliances with other sectors such as environmental

  15. Political activity for physical activity: health advocacy for active transport

    Amun Qa-t-a; Reeder Anthony I; Murdoch Linda; Richards Rosalina

    2011-01-01

    Abstract Effective health advocacy is a priority for efforts to increase population participation in physical activity. Local councils are an important audience for this advocacy. The aim of the current study was to describe features of advocacy for active transport via submissions to city council annual plans in New Zealand, and the impact of an information sheet to encourage the health sector to be involved in this process. Written submissions to city council's annual consultation process w...

  16. Persistent active longitudes in sunspot activity

    Berdyugina, S.; Usoskin, I.

    It has been recently shown that spot activity of cool stars including solar analogues, is grouped in two clearly distinguished active longitudes which are persistent within at least one starspot cycle. Solar data including positional information of individual sunspots / groups extends back for about 130 years covering 12 solar cycles. Here we present the results of our research of longitudinal distribution of sunspot activity using an analysis similar to that applied to the stars. First, we synthesized, from the actual sunspot data, the sun's light curve as if it was defined only by spots. Then solar images were calculated from this light curve, giving a natural smoothing of the spot pattern. For each Carrington rotation, longitudinal position of these smoothed spot regions was calculated. The analysis reveals the following main features: - Sunspot activity is grouped in two active longitudes (with the differential rotation taken into account) 180o apart from each other which are persistent through the entire studied period of 12 cycles, similarly to stars. - The longitude migration is determined by changing the mean latitude of sunspot activity (the Maunder butterfly) and differential rotation. - The two longitudes periodically alternate the dominant activity with about 3.7 year period implying for the existence of the Sflip-flopT phenomenon known in - starspot activity.

  17. Increasing Youth Physical Activity with Activity Calendars

    Eckler, Seth

    2016-01-01

    Physical educators often struggle with ways to get their students to be active beyond the school day. One strategy to accomplish this is the use of physical activity calendars (PACs). The purpose of this article is to support the use of PACs and give practical advice for creating effective PACs.

  18. Modulations of hMOF autoacetylation by SIRT1 regulate hMOF recruitment and activities on the chromatin

    Lu Lu; Lei Li; Xiang Lv; Xue-Song Wu; De-Pei Liu; Chih-Chuan Liang

    2011-01-01

    A wide variety of nuclear regulators and enzymes are subjected to acetylation of the lysine residue, which regulates different aspects of protein functions. The MYST family histone acetyltransferase, human ortholog of MOF (hMOF), plays critical roles in transcription activation by acetylating nucleosomai H4K16. In this study, we found that hMOF acetylates itself in vitro and in vivo, and the acetylation is restricted to the conserved MYST domain (C2HC zinc finger and HAT), of which the K274 residue is the major autoacetylation site. Furthermore, the class Ⅲ histone deacetylase SIRT1 was found to interact with the MYST domain of hMOF through the deacetylase catalytic region and deacetylate autoacetylated hMOF. In vitro binding assays showed that non-acetylated hMOF robustly binds to nucleosomes while acetylation decreases the binding ability. In HeLa cells, the recruitment of hMOF to the chromatin increases in response to SIRT1 overexpression and decreases after knockdown of SIRT1. The acetylation mimic mutation K274Q apparently decreases the chromatin recruitment of hMOF as well as the global H4K16Ac level in HeLa cells. Finally, upon SIRT1 knockdown, hMOF recruitment to the gene body region of its target gene HoxA9 decreases, accompanied with decrease of H4K16Ac at the same region and repression of HoxA9 transcription. These results suggest a dynamic interplay between SIRT1 and hMOF in regulating H4K16 acetylation.

  19. Neutron Activation Analysis

    Corliss, William R.

    1968-01-01

    In activation analysis, a sample of an unknown material is first irradiated (activated) with nuclear particles. In practice these nuclear particles are almost always neutrons. The success of activation analysis depends upon nuclear reactions which are completely independent of an atom's chemical associations. The value of activation analysis as a research tool was recognized almost immediately upon the discovery of artificial radioactivity. This book discusses activation analysis experiments, applications and technical considerations.

  20. Active Player Modelling

    Togelius, Julian; Shaker, Noor; Yannakakis, Georgios N.

    2013-01-01

    We argue for the use of active learning methods for player modelling. In active learning, the learning algorithm chooses where to sample the search space so as to optimise learning progress. We hypothesise that player modelling based on active learning could result in vastly more efficient learning, but will require big changes in how data is collected. Some example active player modelling scenarios are described. A particular form of active learning is also equivalent to an influential forma...

  1. Informal Economic Activities

    Bühn, Andreas

    2010-01-01

    The dissertation “Informal Economic Activities” takes a comprehensive approach to the informal economy by studying traditional shadow economic activities, household DIY activities, and the smuggling of illegal and legal goods. Chapter 2 analyzes shadow economic and DIY activities and presents a dual estimation for the development of both types of informal economic activities in Germany from 1970 to 2005. It also considers the impact of German reunification on shadow economic and DIY activ...

  2. Hat die Psychiatrie Aufgaben in der Diagnostik gesellschaftlicher Befindlichkeiten und Problemlagen?

    Emrich HM

    2009-01-01

    Full Text Available Hinsichtlich der Frage nach gesellschaftlichen Befindlichkeiten und Problemlagen erscheint es sinnvoll, die verschiedenen soziologischen Reflexionsebenen zu unterscheiden: die mikrosoziale Ebene, den Mesobereich und die Makroebene der Politik. Die gesellschaftlichen Problemlagen und emotionalen Situationen werden dabei in der Gegenwart sehr stark durch die Konzepte der "postmodernen Hyperflexibilität" (Lyotard geprägt, wobei insbesondere auch die Medien eine zentrale Funktion einnehmen. Hierbei zeigt sich, dass es eine neue Form von Inszenierungen und Selbstdarstellungen gibt, die man als "Hysterie als Lebensform" charakterisieren kann.

  3. White Hat Search Engine Optimization (SEO: Structured Web Data for Libraries

    Dan Scott

    2015-06-01

    Full Text Available “White hat” search engine optimization refers to the practice of publishing web pages that are useful to humans, while enabling search engines and web applications to better understand the structure and content of your website. This article teaches you to add structured data to your website so that search engines can more easily connect patrons to your library locations, hours, and contact information. A web page for a branch of the Greater Sudbury Public Library retrieved in January 2015 is used as the basis for examples that progressively enhance the page with structured data. Finally, some of the advantages structured data enables beyond search engine optimization are explored

  4. "Die Nato hat einen grossen Fehler begangen" / Toomas Hendrik Ilves ; interv. Ansgar Graw

    Ilves, Toomas Hendrik, 1953-

    2008-01-01

    Eesti president räägib sõjalistest kokkupõrgetest Gruusias, vajadusest uue rahvusvahelise julgeolekustruktuuri järele, ootustest rahvusvahelise üldsuse suhtes, Balti riikide julgeolekust ning kritiseerib NATO otsust mitte anda Gruusiale NATO liikmelisuse tegevuskava

  5. $\\Delta I=1/2$ Rule and $\\hat B_K$ : 2014

    Buras, Andrzej J

    2014-01-01

    I summarize the status of the $\\Delta I=1/2$ rule in $K\\to\\pi\\pi$ decays within an {\\it analytic} approach based on the dual representation of QCD as a theory of weakly interacting mesons for large $N$, where $N$ is the number of colours. This approximate approach, developed in the 1980s by William Bardeen, Jean-Marc G\\'erard and myself identified already 28 years ago the dominant dynamics behind the $\\Delta I=1/2$ rule. However, the recent inclusion of lowest-lying vector meson contributions in addition to the pseudoscalar ones to hadronic matrix elements of current-current operators and the calculation of the corresponding Wilson coefficients in a momentum scheme at the NLO improved significantly the matching between quark-gluon short distance contributions and meson long distance contributions over our results in 1986. We obtain satisfactory description of the ${\\rm Re}A_2$ amplitude and ${\\rm Re}A_0/{\\rm Re}A_2=16.0\\pm 1.5$ to be compared with its experimental value of $22.3$. While this difference could ...

  6. CALLIGRAPHY OF STACKED FRUIT IN ART OF CALLIGRAPHY / HAT SANATINDA MEYVE ISTIFLI HATLAR

    Dr. Zübeyde Cihan ÖZSAYINER

    2008-10-01

    Full Text Available Calligraphy with stacked fruit in the art ofcalligraphy In Turkish culture fruit has created afundamental element used lovingly in architecture,calligraphy, miniatures, woodwork, metalwork, porcelain art, carpets, towels, edging, printed cloth, embroidery,folk art and gravestones. As a result of studies, it hasbeen shown that fruit has the symbolic meanings ofimmortality, the existence that is the core of something, ajewel and truth. It is seen that the symbolisms of fruit byitself changes according to societies. The apple becamethe fruit of the tree in paradise and the “golden apple” isthe symbol of immortality. The grape symbolizes autumn,the pomegranate bountifulness, reproduction, maternityand birth. As a result of my research in the art ofcalligraphy it has been proven that there are manuscriptsreflecting religious and mystic subjects have beenstacked neatly in the forms of pears, apples andpomegranate. In the Turkish Foundation CalligraphicArts Museum, the only such one in Turkey and in theworld there are three examples of calligraphy neatlystacked in pear form. It seems that the stacked fruit inthe form of pears, apples and pomegranates and writtenin various techniques were lovingly used by calligrapherswho had great creative power, sought change in theTurkish art of calligraphy and worked in religious andmystic circles.

  7. Who has priority during the regulation?; Wer hat Vorrang beim Abregeln?

    Janzing, Bernward

    2013-04-15

    The remote control of wind power plants by direct marketers raises questions - not only on the technology, but also on the hierarchy of actors. From the technical perspective, the current practice of feed-in is not particularly well developed. So far, the regulation of wind turbines via radio ripple control is carried out in stages to 60, 30 and 0 %. The traditional ripple control technology does not send a message back to the sender if the wind turbine has received the signal and reacts to it. Smart meter and digital control technology can provide assistance in this case. Consequences for the plant safety result from this regulation: The performance of a wind turbine shall be reduced only with a gradient of ten percent of the initial output per minute. If the data transfer is interrupted, the reduction of the power will be closed automatically after 30 minutes.

  8. Dithiothreitol revisited in red cells : a new head for an old hat

    Almeida, J. P. Lopes de; Saldanha, C.

    2010-01-01

    In the present article the authors make an approach over the applications of dithiothreitol (DTT) in its different clinicallaboratory, potential and up-to-date sources. Dithiothreitol is a chemical reagent with a wide actuation spectrum not only from a laboratorial view but also from a therapeutic standpoint, more clinical and practical. DTT (i) is frequently used in a variety of experiences that involve proteins or peptides, protecting sulfhydryl groups from oxidation and reducing d...

  9. The effect of hat on phototherapy-induced hypocalcemia in jaundiced full-term neonates

    Ezzeldin Z; Mansi Y; Abdelhamid TA; Sabry M

    2015-01-01

    Zahraa Ezzeldin, Yasmeen Mansi, Tamer A Abdelhamid, Mohamed Sabry Department of Pediatrics, Faculty of Medicine, Cairo University, Giza, Egypt Background: It has been hypothesized that phototherapy leads to increased calcium absorption by the bones through irradiating the pineal gland and reducing melatonin level. There is some evidence that the use of a stockinet cap to cover the head prevents phototherapy-induced hypocalcemia. Study design: This was a randomized controlled trial, including...

  10. The rabbit in the hat: dubious argumentation and the persuasive effects of prescription drug advertising (DTCA).

    Rubinelli, Sara; Nakamoto, Kent; Schulz, Peter J

    2008-01-01

    There is an ongoing global debate over the potential benefits and risks of allowing direct-to-consumer advertising of prescription medicines (DTCA). The core of this debate concerns the identification of DTCA either as a beneficial procedure to be promoted or as a damaging procedure to be abolished. Economic data on DTCA suggest that this form of advertising has an impact on consumers. Based on this premise, we explore the use of argumentation theory to inquire into the reasons for this success. In particular, by combining perspectives from argumentation theory and marketing research this paper aims to test the hypothesis of whether DTCA presents information framed in potentially misleading, but persuasive, argumentative structures. We highlight and discuss the results of two studies designed to assess whether readers perceive DTCA as argumentative and, if so, which explicit and implicit elements provide groundings for the inference that consumers draw from the ads. The analysis highlights the presence in DTCA of dubious arguments (fallacies and distracting claims) that may go unnoticed. Also, it illustrates the nature of readers' wrong assumptions that arise independently from the contents of the ads. These factors seem to influence the level of the self-perceived persuasiveness of DTCA. PMID:19363879

  11. The Epidemiology of Childhood Asthma in Red Deer and Medicine Hat, Alberta

    Patrick A Hessel

    2001-01-01

    Full Text Available OBJECTIVES: To document the prevalence of asthma among school-aged children in two Alberta communities, to understand host and indoor environmental factors associated with asthma, and to compare these factors between the two communities.

  12. Red Hat Fedora Linux 2 All-in-One Desk Reference For Dummies

    Barkakati, Naba

    2004-01-01

    This essential reference organizes material into a set of nine stand-alone, task-oriented minibooks that enable readers to understand all aspects of the Fedora OS, the latest release of the most popular Linux distributionEach minibook covers a different aspect of Fedora, such as getting users started with Fedora, the various workstations and applications, OpenOffice.org, networking, system administration, security, running Internet servers on a Fedora system, and programmingMore experienced readers can use this desktop reference to look up how to perform specific tasks, such as hooking up to t

  13. The Many Hats of an Instructional Designer: The Development of an Instructional Card Game.

    Sugar, William; Betrus, Anthony

    2002-01-01

    Discusses the difficulties in defining instructional technology, suggests core competencies, proposes five instructional designer archetypes, and describes the development of an instructional card game designed for graduate students in instructional design to expose them to major responsibilities of an instructional designer and give them insight…

  14. "Tied together like a woven hat:" Protective pathways to Alaska native sobriety

    Mohatt Gerald V

    2004-11-01

    Full Text Available Abstract Background The People Awakening Project (1RO1 AA 11446-03 had two purposes, completed in Phase I and Phase II of the project. The purpose of Phase I was to complete a qualitative study; the research objective was discovery oriented with the specific aim of identification of protective and recovery factors in Alaska Native sobriety. Results were used to develop a heuristic model of protective and recovery factors, and measures based on these factors. The research objective of Phase II was to pilot these measures and provide initial validity data. Methods Phase I utilized a life history methodology. People Awakening interviewed a convenience sample of 101 Alaska Natives who had either recovered from alcoholism (n = 58 or never had a drinking problem (n = 43. This later group included both lifetime abstainers (LAs and non-problem drinkers (NPs. Life histories were transcribed and analyzed using grounded theory and consensual data analytic procedures within a participatory action research framework. Analyses were utilized to generate heuristic models of protection and recovery from alcohol abuse among Alaska Natives. Results Analyses generated a heuristic model of protective factors from alcohol abuse. The resulting multilevel and multi-factorial model describes interactive and reciprocal influences of (a individual, family, and community characteristics; (b trauma and the individual and contextual response to trauma, (c experimental substance use and the person's social environment; and (d reflective processes associated with a turning point, or a life decision regarding sobriety. The importance of cultural factors mediating all these protective processes is emphasized. For NPs, the resilience process drew from personal stores of self-confidence, self-efficacy, and self-mastery that derived from ability to successfully maneuver within stressful or potentially traumatizing environments. In contrast, for many LAs, efficacy was instead described in more socially embedded terms better understood as communal mastery. One style of mastery is more associated with individualistic orientations, the other with more collectivistic. Future research is needed regarding the generalizeability of this group difference. Conclusions Results suggest that preventative interventions should focus on intervening simultaneously at the community, family, and individual levels to build resilience and protective factors at each level. Of particular importance is the building of reflexivity along with other cognitive processes that allow the individual to think through problems and to reach a life decision to not abuse alcohol.

  15. "...dass man einen festen Glauben daran hat, dass das jetzige System die Rettung sei"

    Lammers, Karl Christian

    Undersøgelse af den danske gesandt i Berlin Herluf Zahles beretning om og vurdering af forholdet mellem Hitler og tyskerne.......Undersøgelse af den danske gesandt i Berlin Herluf Zahles beretning om og vurdering af forholdet mellem Hitler og tyskerne....

  16. The Sorting Hat Effect: How the Hogwarts Houses Influence Prejudice in Harry Potter

    Helga Sædís Jónsdóttir 1994

    2016-01-01

    This essay explores the various prejudices shown in the Harry Potter book series by J.K. Rowling. Hogwarts is the only wizarding school in Great Britain and as every witch or wizard in Great Britain passes through the doors of the school, the school has an enormous influence on the magical community. At Hogwarts rivalry between the four houses is encouraged and the students are conditioned to look down on the students of the other houses and anything they associate with each house. Outside of...

  17. Nuclear power has a future; Kernenergie hat Zukunft. Eroeffnungsrede zur Wintertagung des Deutschen Atomforums in Berlin

    Majewski, O. [Bayernwerk AG, Muenchen (Germany)

    2000-03-01

    Consensus is possible. This is the message of the President of the Deutsches Atomforum, Dr. Otto Majewski, at the opening of the Forum's Winter Meeting in Berlin. Majewski emphasized that the operators of nuclear power plants urgently needed security in planning, given the rapid change in the European electricity market. It was time to get away from the onesided discussion about running times and opt-out, and focus again on the entire spectrum of a long term, calculable, reliable energy policy. Besides a sustainable clarification of the transport issue, the retroactive taxation of the reserves accumulated for waste management constituted an unacceptable burden on operators. Companies would take legal action against these measures, should it turn out to be necessary. Dr. Majewski expressed himself unequivocally in favour of the EPR as a reactor line for the future. (orig.) [German] 'Ein Konsens ist moeglich. Aber anstatt an starren Laufzeiten zu kleben, gilt es einen intelligenten Loesungsansatz zu finden', so Dr. Otto Majewski, Praesident des Deutschen Atomforums zur Eroeffnung der DAtF-Wintertagung in Berlin. Majewski machte deutlich, dass die deutschen Kernenergie-Betreiber vor dem Hintergrund des raschen Wandels im europaeischen Strommarkt vor allem Planungssicherheit brauchen. Die Ueberlegung, ueber Laufzeit- bzw. Strommengen-Kontingente zu verhandeln, haelt Majewski fuer einen denkbaren Ansatz. Neben der nachhaltigen Klaerung der Transportfrage sei die rueckwirkende Besteuerung der Entsorgungsrueckstellungen eine unakzeptable Belastung der Betreiber. Der DAtF-Praesident bekraeftigte die Entschlossenheit der Unternehmen, diese Bestimmungen notfalls vor Gericht zu Fall zu bringen. Gleichzeitig sparch er sich fuer den EPR als kuenftige Reaktorlinie aus. (orig.)

  18. Commodity Cluster Computing for Remote Sensing Applications using Red Hat LINUX

    Dorband, John

    2003-01-01

    Since 1994, we have been doing research at Goddard Space Flight Center on implementing a wide variety of applications on commodity based computing clusters. This talk is about these clusters and haw they are used on these applications including ones for remote sensing.

  19. HAT Variability Survey in the High Stellar Density "Kepler Field" with Millimagnitude Image Subtraction Photometry

    Hartman, J D; Stanek, K Z; Noyes, R W

    2004-01-01

    The Hungarian-made Automated Telescope network (HATnet) is an ongoing project to detect transiting extra-solar planets using small aperture, robotic telescopes. In this paper we present the results from using image subtraction photometry to reduce a crowded stellar field (chosen to overlap with the planned Kepler mission). We obtained I-band light curves for 98,000 objects in a 8.3x8.3 square degree field of view, near the Galactic plane in the constellations Cygnus and Lyra. These observations include 788 5-minute exposures over 30 days. For the brightest stars (I~8.0) we achieved a precision of 3.5 millimagnitudes, falling to 0.1 magnitudes at the faint end (I~14). From these light curves we identify 1617 variable stars, of which 1489 are newly discovered. The fact that > 90% of the variables were previously undetected further demonstrates the vast number of variables yet to be discovered even among fairly bright stars in our Galaxy. We also discuss some of the most interesting cases. These include: V1171 C...

  20. IMAGINE OF MEVLANA IN ARİF NİHAT ASYA THE MODERN MEVLEVİ DISCIPLE

    Hasan AKTAŞ

    2008-06-01

    Full Text Available As for Mevlana is a school in Turkish literature, Mevlevilik is a school in Turkish history. Through the history, a great many poet and mystic are trained in those schools. One of them is being among the last poets of modern period Arif Nihat Asya, who can collect poetship and mysticism in his identity. Besides he is a poet and pious, he is also the modern Mevlevi disciple.How does Mevlana's image present appearance on such an equipped poet? This article aims to render Mevlana's image to centrate condition from poet's perspective with the help of Arif Nihat Asya's poems.

  1. Six thinking hats for electricity markets simulation: adapting meeting tools to agent decision

    Barreto, João Costa Borges

    2012-01-01

    In almost all industrialized countries, the energy sector has suffered a severe restructuring that originated a greater complexity in market players’ interactions. The complexity that these changes brought made way for the creation of decision support tools that facilitate the study and understanding of these markets. MASCEM – “Multiagent Simulator for Competitive Electricity Markets” arose in this context providing a framework for evaluating new rules, new behaviour, and new participants ...

  2. "Good Guys Don't Wear Hats": Children's Talk about the Media.

    Tobin, Joseph

    This book details an ethnographic study focused on how children think and talk about media representations of violence, gender, race, colonialism, and social class. Participating in the study were 162 elementary school students in Hawaii. Groups of 6- to 12-year-olds viewed clips from 2 television commercials and 2 movies and were later…

  3. Hat die Finanzkrise zu einer instabilen Geldnachfrage geführt?

    Dreger, Christian; Wolters, Jürgen

    2010-01-01

    A stable money demand relationship is one of the pre-conditions for a successful monetary policy of the European Central Bank (ECB). In this contribution we examine the stability of money demand in the euro area by taken the period of the financial crisis into account. Our results indicate that the broad monetary aggregate M3 has developed still in line with the macroeconomic fundamentals. From an empirical perspective, the specifications should include house prices, as they play a significan...

  4. Zur klinischen Bedeutung von Geschwistererfahrungen - hat die Geschwistererfahrung einen Einfluss auf seelische Erkrankungen?

    Adam-Lauterbach, Dorothee

    2012-01-01

    Im Mittelpunkt der Arbeit steht die Frage, ob bei psychogenen Störungen Geschwistererfahrungen klinische Relevanz haben und ob die erfahrene Geschwisterposition und –konstellation auch im Erwachsenenalter psychodynamisch wirksam ist. Die Arbeit gliedert sich in drei Teile. Im ersten Teil werden in einem metatheoretischen Vorgehen psychoanalytische Konzepte, psychoanalytische Entwicklungstheorien aus der Objekt- und Selbstpsychologie und empirische Forschungsergebnisse zur Geschwisterbezie...

  5. Brand Communities and Well-being: Learning to Age in a Red Hat

    Moscato, Emily Marie

    2014-01-01

    The older female segment plays a critical role in society's fabric, as women past retirement volunteer a significant amount in their communities and provide essential caregiving to family members and friends. Moreover, older females outnumber older males and with the baby boomer population aging over 65, this segment is becoming more influential. Yet there is surprisingly little marketing research that focuses on this older female segment, their lived experiences, and their well-being. Workin...

  6. Emissionsvermeidung oder Anpassung an den Klimawandel: Welche Zukunft hat die Klimapolitik?

    Hubertus Bardt; Feld, Lars P.; Konrad, Kai A.; Marcel Thum; Wolfgang Buchholz; Dirk Rubbelke; Christian Hey; Karin Holm-Muller; Michael Weber; Rudiger Pethig; Joachim Weimann; Timo Goeschl

    2011-01-01

    Die gegenwärtige im Kyoto-Protokoll festgelegte Klimapolitik versucht vorrangig, dem Klimawandel mit einer Strategie der Emissionsverminderung zu begegnen. Die dort festgelegten Reduktionsziele für den CO2-Ausstoß sind für viele Länder nicht mehr zu realisieren. Und einige Länder, die zu den größten Emittenten gehören, vor allem die USA, haben sich dem Kyoto-Protokoll nicht angeschlossen. Sollte die Klimapolitik in Zukunft weniger auf Emissionsvermeidung und eher auf eine Anpassung an die Erd...

  7. CETA: Welche Effekte hat das EU-Kanada-Freihandelsabkommen auf Deutschland?

    Rahel Aichele; Gabriel Felbermayr

    2014-01-01

    Das CETA-Abkommen sieht die Abschaffung von Zöllen, regulatorische Zusammenarbeit und Investitionsschutz zwischen der EU und Kanada vor. Nach unseren Simulationsrechnungen könnte es langfristig die Exporte Deutschlands nach Kanada verdreifachen und die Importe verdoppeln. CETA könnte in Deutschland einen langfristigen Zuwachs des realen Pro-Kopf-Einkommens von 0,2% ermöglichen; Kanada würde jedoch deutlich stärker profitieren. Der größte Nutznießer in Deutschland wäre der Fahrzeugbau; der Ber...

  8. [Trabecular hyalinizing adenoma of the thyroid (HAT): A report of two cases].

    Román-González, Alejandro; Simón-Duque, Carlos; Camilo-Pérez, Juan; Vélez-Hoyo, Alejandro

    2016-01-01

    The hyalinizing trabecular adenoma is a rare lesion of the thyroid. There is controversy in the literature about the correct name for this disease. Dr. Carney defended the benign nature of this condition and therefore continues calling it adenoma, the World Health Organization calls for the potential of tumor malignancy, and others qualify it as a variant of papillary carcinoma based on the presence of rearranged in transformation/papillary thyroid carcinoma (RET/PTC) rearrangements. In Latin America there are few reported cases. Two cases of hyalinizing trabecular adenoma are reported. The first is a 40-year-old woman with a thyroid nodule of 3x3 cm. The immunohistochemistry was positive for thyroglobulin and calcitonin and negative for cytokeratin 19 and chromogranin. The second case is a 36-year-old patient with a thyroid nodule of 4x4 cm with an immunohistochemical pattern identical to the first case. Trabecular hyalinizing adenoma is a benign disease, easily confused with papillary or medullary thyroid carcinoma. Awareness of this entity will allow a better classification and management of thyroid conditions. PMID:26927651

  9. College Hats or Lecture Trousers? Stage Fright and Performance Anxiety in University Teachers

    Scott, Susie

    2007-01-01

    This article examines the experience of "stage fright" in teachers in higher education, drawing on the dramaturgical perspective from sociology. Interviews were conducted with 10 "novice" and "expert" lecturers, alongside focus groups with undergraduate students, to compare their perceptions and expectations. The students defined a good lecturer…

  10. Histone Acetyl Transferase (HAT) HBO1 and JADE1 in Epithelial Cell Regeneration

    Havasi, Andrea; Haegele, Joseph A.; Gall, Jonathan M.; Blackmon, Sherry; Ichimura, Takaharu; Bonegio, Ramon G.; Panchenko, Maria V.

    2013-01-01

    HBO1 acetylates lysine residues of histones and is involved in DNA replication and gene transcription. Two isoforms of JADE1, JADE1S and JADE1L, bind HBO1 and promote acetylation of histones in chromatin context. We characterized the role of JADE1-HBO1 complexes in vitro and in vivo during epithelial cell replication. Down-regulation of JADE1 by siRNA diminished the rate of DNA synthesis in cultured cells, decreased endogenous HBO1 protein expression, and prevented chromatin recruitment of re...

  11. Wearing More than One Hat: Improving Student-Authored Case Longevity while Encouraging Additional Student Roles

    Corrigan, Hope; Craciun, Georgiana

    2012-01-01

    The marketing education literature emphasizes and documents the effectiveness of using the student-authored case (SAC) method as a means to develop managerial and critical thinking skills. However, most SACs are short lived, lack suggested case solutions, do not benefit from peer feedback, and present challenges in finding relevant company data.…

  12. Moccasins into Slippers: Woodlands Indian Hats, Bags, and Shoes in Tradition and Transformation.

    Phillips, Ruth B.

    1990-01-01

    In the mid-nineteenth century, an abrupt transformation occurred in textiles and other art forms of northeastern Woodlands Indians. Trade, tourism, and survival needs sparked changes in materials used and garment types produced, as well as substitution of a new vocabulary of floral imagery for "pagan" iconographic traditions. (SV)

  13. Deutsche Weine und ihre Stellung in Norwegen : hat die "Renaissance des Rieslings" Norwegen erreicht?

    2006-01-01

    In dieser Masterarbeit wird die Geschichte des deutschen Weinanbaus erzählt und die Stellung deutscher Weine in Norwegen untersucht. In der zweiten Hälfte des 20. Jahrhunderts setzten immer mehr deutsche Winzer auf Quantität statt auf Qualität, woraufhin der deutsche Weinanbau allmählich sein gutes Ansehen verlor. Zwar waren massenhaft produzierte preiswerte, süße Weine, besonders die „Liebfraumilch“, äußerst beliebte Exportwaren, jedoch drängten sie die Prädikatsweine fast vollständig in den...

  14. Many Hats and a Delicate Balance: The Lives and Times of Today's Special Education Directors

    Thompson, James R.; O'Brian, Mary

    2007-01-01

    A statewide survey of special education directors revealed that director of special education preparation programs should be time limited and offered in convenient locations to recruit the best possible pool of students and future directors. Current directors have come to their positions through numerous and diverse career paths. The lack of…

  15. And$\\hat{o}$-Douglas type characterization of generalized conditional expectations, optional projections and predictable projections

    Hong, Liang

    2014-01-01

    Generalized conditional expectations, optional projections and predictable projections of stochastic processes play important roles in the general theory of stochastic processes, semimartingale theory and stochastic calculus. They share some important properties with ordinary conditional expectations. While the characterization of ordinary conditional expectations has been studied by several authors, no similar work seems to have been done for these three concepts. This paper aims at undertak...

  16. Calculating the Jet Quenching Parameter $\\hat{q}$ in Lattice Gauge Theory

    Majumder, Abhijit

    2012-01-01

    We present a framework where first principles calculations of jet modification may be carried out in a non-perturbative thermal environment. As an example of this approach, we compute the leading order contribution to the transverse momentum broadening of a high energy (near on-shell) quark in a thermal medium. This involves a factorization of a non-perturbative operator product from the perturbative process of scattering of the quark. An operator product expansion of the non-perturbative operator product is carried out and related via dispersion relations to the expectation of local operators. These local operators are then evaluated in quenched SU(2) lattice gauge theory.

  17. Frihet till hat? : Hatbrott, rasistiska organisationer och inskränkningar av yttrandefriheten

    Peippo, Patric

    2011-01-01

    The present paper is part of a project carried on by the Swedish Section of the International Commission of Jurists. Sweden has ratified several major international human rights instruments. Most of the rights are covered by national law, and only in exception is there a discrepancy between national and international law. Such a discrepancy is found in the UN Convention on the Elimination of all forms of Racial Discrimination, in which the State parties agree on penalizing and prohibiting the...

  18. 基于Red Hat Linux9的DNS系统研究

    高源

    2009-01-01

    DNS是域名系统(Domain Name System)的缩写,该系统用于命名组织到域层次结构中的计算机和网络服务。互联网中的DNS服务器绝大多数是基于Linux系统创建的。从Linux DNS的初级配置着手,对快速配置出简单有效的DNS服务器进行了论述。

  19. Indigenous Knowledge in the Life Sciences Classroom: Put on Your de Bono Hats!

    de Beer, Josef; Whitlock, Elrina

    2009-01-01

    The whole world was united in its condemnation of the pre-1994 apartheid regime in South Africa. Apartheid meant that many South Africans were robbed of their democratic voices and cultural identities. In this article, the authors pose the question: Are you guilty of "knowledge apartheid" in your biology classroom? Does every student have a voice…

  20. Hard Hats, Octopuses and Rubber Boots- Operational Managers in Building Processes

    Koch, Christian

    2004-01-01

    place itself in between those extremes in twofold manner, first by conceptually arguing that building processes encompass requisite parallelism and fragmentation due to their predominantly quantitative complexity. Second by doing an exploratory field study, drawing a modified lean construction...

  1. The G-HAT Infrared Search for Extraterrestrial Civilizations with Large Energy Supplies

    Wright, Jason Thomas; Povich, Matthew; Griffith, Roger; Maldonado, Jessica; Sigurdsson, Steinn; Star Cartier, Kimberly

    2015-08-01

    The WISE and Spitzer large-area surveys of the mid-infrared sky bring a new opportunity to search for evidence of the energy supplies of very large extraterrestrial civilizations. If these energy supplies rival the output of a civilization's parent star (Kardashev Type II), or if a galaxy-spanning supercivilization's use rivals that of the total galactic luminosity (Type III), they would be detectable as anomolously mid-infrared-bright stars and galaxies, respectively. We have already performed the first search for this emission from Type III civilizations using the WISE all-sky survey, and put the first upper limits on them in the local universe, and discuss ways to improve on these limits. We also discuss some detectable forms of and limits on Type II civilizations in the Mliky Way.

  2. Schweizerische Nationalökonomie: Was hat sich in den letzten 20 Jahren bewegt?

    Ernst Baltensperger

    2002-01-01

    Economics in Switzerland: What has changed over the last 20 years? Swiss economics and economists have opened up vis-à-vis the rest of the world to a considerable extent. Today, the degree of internationalisation and research orientation is markedly higher than it was 20 years ago. Nevertheless, there is still room for further improvement. The paper offers an overview of a number of significant developments since the early 1980s.

  3. Lectures Abandoned: Active Learning by Active Seminars

    Christensen, Henrik Bærbak; Corry, Aino Vonge

    2012-01-01

    Traditional lecture-based courses are widely criticised for be- ing less eective in teaching. The question is of course what should replace the lectures and various active learning tech- niques have been suggested and studied. In this paper, we report on our experiences of redesigning a software ......- tive seminars as a replacement of traditional lectures, an activity template for the contents of active seminars, an ac- count on how storytelling supported the seminars, as well as reports on our and the students' experiences....

  4. Antifeedant activity of quassinoids.

    Leskinen, V; Polonsky, J; Bhatnagar, S

    1984-10-01

    The antifeedant activity of 13 quassinoids of different structural types has been studied against the Mexican bean beetle (Epilachna varivestis Mulsant) 4th instar larvae and the southern armyworm (Spodoptera eridania Crawer) 5th instar larvae. All quassinoids tested displayed significant activity against the Mexican bean beetle and, thus, do not reveal a simple structure-activity relationship. Five quassinoids were active against the southern armyworm. Interestingly, four of these-bruceantin (I), glaucarubinone (VI), isobruceine A (VIII), and simalikalactone D (XI)-possess the required structural features for antineoplastic activity. The noncytotoxic quassin (X) is an exception; it is active against both pests. PMID:24318349

  5. Flip flops, dress clothes, and no coat: clothing barriers to children's physical activity in child-care centers identified from a qualitative study

    Saelens Brian E

    2009-11-01

    Full Text Available Abstract Background Three-quarters of 3-6 year-old children in the U.S. spend time in childcare; many spend most of their waking hours in these settings. Daily physical activity offers numerous health benefits, but activity levels vary widely across centers. This study was undertaken to explore reasons why physical activity levels may vary. The purpose of this paper is to summarize an unexpected finding that child-care providers cited was a key barrier to children's physical activity. Methods Nine focus groups with 49 child-care providers (55% black from 34 centers (including inner-city, suburban, Head Start and Montessori were conducted in Cincinnati, OH. Three independent raters analyzed verbatim transcripts for themes. Several techniques were used to increase credibility of findings, including interviews with 13 caregivers. Results Two major themes about clothing were: 1 children's clothing was a barrier to children's physical activity in child-care, and 2 clothing choices were a significant source of conflict between parents and child-care providers. Inappropriate clothing items included: no coat/hat/gloves in the wintertime, flip flops or sandals, dress/expensive clothes, jewelry, and clothes that were either too loose or too tight. Child-care providers explained that unless there were enough extra coats at the center, a single child without a coat could prevent the entire class from going outside. Caregivers suggested several reasons why parents may dress their child inappropriately, including forgetfulness, a rushed morning routine, limited income to buy clothes, a child's preference for a favorite item, and parents not understanding the importance of outdoor play. Several child-care providers favored specific policies prohibiting inappropriate clothing, as many reported limited success with verbal or written reminders to bring appropriate clothing. Conclusion Inappropriate clothing may be an important barrier to children's physical

  6. Forensic activation analysis

    Basic principles of neutron activation analysis are outlined. Examples of its use in police science include analysis for gunshot residues, toxic element determinations and multielement comparisons. Advantages of neutron activation analysis over other techniques are described. (R.L.)

  7. Family Activities for Fitness

    Grosse, Susan J.

    2009-01-01

    This article discusses how families can increase family togetherness and improve physical fitness. The author provides easy ways to implement family friendly activities for improving and maintaining physical health. These activities include: walking, backyard games, and fitness challenges.

  8. USAID Activity Locatons

    US Agency for International Development — The USAID Activities dataset is a snapshot of activities supported by USAID including their geographical locations within countries at the time of the snapshot. The...

  9. Italian active volcanoes

    RobertoSantacroce; RenawCristofolini; LuigiLaVolpe; GiovanniOrsi; MauroRosi

    2003-01-01

    The eruptive histories, styles of activity and general modes of operation of the main active Italian volcanoes,Etna, Vulcano, Stromboli, Vesuvio, Campi Flegrei and Ischia, are described in a short summary.

  10. Major operations and activities

    This section of the 1994 Hanford Site Environmental Report summarizes the major operations and activities on the site. These operations and activities include site management, waste management, environmental restoration and corrective actions, and research and technology development

  11. Physical Activity and Children

    ... Food and Beverage Toolkit The AHA's Recommendations for Physical Activity in Children Updated:Jul 21,2016 Click image ... Inactive children are likely to become inactive adults. Physical activity helps with: controlling weight reducing blood pressure raising ...

  12. Active Marine Station Metadata

    National Oceanic and Atmospheric Administration, Department of Commerce — The Active Marine Station Metadata is a daily metadata report for active marine bouy and C-MAN (Coastal Marine Automated Network) platforms from the National Data...

  13. Immunizations: Active vs. Passive

    ... in Action Medical Editor & Editorial Advisory Board Sponsors Sponsorship Opporunities Spread the Word Shop AAP ... Active vs. Passive Page Content Article Body Pediatricians can protect your child by administering not only active immunizations , but sometimes ...

  14. Preschoolers’ Physical Activity Behaviours

    Irwin, Jennifer D.; He, Meizi; Bouck, L. Michelle Sangster; Tucker, Patricia; Pollett, Graham L.

    2016-01-01

    Objectives To understand parents’ perspectives of their preschoolers’ physical activity behaviours. Methods A maximum variation sample of 71 parents explored their preschoolers’ physical activity behaviours through 10 semi-structured focus group discussions. Results Parents perceived Canada’s Physical Activity Guidelines for Children as inadequate; that their preschoolers get and need more than 30–90 minutes of activity daily; and that physical activity habits must be established during the preschool years. Nine barriers against and facilitators toward adequate physical activity were proposed: child’s age, weather, daycare, siblings, finances, time, society and safety, parents’ impact, and child’s activity preferences. Discussion The need for education and interventions that address current barriers are essential for establishing physical activity as a lifestyle behaviour during early childhood and, consequently, helping to prevent both childhood and adulthood obesity. PMID:16625802

  15. Major operations and activities

    Black, D.G.

    1995-06-01

    This section of the 1994 Hanford Site Environmental Report summarizes the major operations and activities on the site. These operations and activities include site management, waste management, environmental restoration and corrective actions, and research and technology development.

  16. Activity-based design

    Andersen, Peter Bøgh

    2006-01-01

      In many types of activities communicative and material activities are so intertwined that the one cannot be understood without taking the other into account. This is true of maritime and hospital work that are used as examples in the paper. The spatial context of the activity is also important:...... and automatic machinery can replace one another in an activity. It also gives an example of how to use the framework for design....

  17. Canonical active Brownian motion

    Gluck, Alexander; Huffel, Helmuth; Ilijic, Sasa

    2008-01-01

    Active Brownian motion is the complex motion of active Brownian particles. They are active in the sense that they can transform their internal energy into energy of motion and thus create complex motion patterns. Theories of active Brownian motion so far imposed couplings between the internal energy and the kinetic energy of the system. We investigate how this idea can be naturally taken further to include also couplings to the potential energy, which finally leads to a general theory of cano...

  18. Woodsy Owl Activity Guide.

    Forest Service (USDA), Washington, DC.

    This guide offers teachers and after-school group leaders 12 fun and engaging activities. Activities feature lessons on trees, water, wind, the earth, food, and waste. The activities are designed to help children aged 5-8 become more aware of the natural environment and fundamental conservation principles. Titles of children's books are embedded…

  19. Activity Theory and Ontology

    Peim, Nick

    2009-01-01

    This paper seeks to re-examine Yrio Engestrom's activity theory as a technology of knowledge designed to enable positive transformations of specific practices. The paper focuses on a key paper where Engestrom defines the nature and present state of activity theory. Beginning with a brief account of the relations between activity theory and…

  20. Recurrent Activity in Active Galactic Nuclei

    Saikia, D J

    2010-01-01

    There has been a growing body of evidence to suggest that AGN activity, which is powered by mass accretion on to a supermasive black hole, could be episodic, although the range of time scales involved needs to be explored further. The structure and spectra of radio emission from radio galaxies, whose sizes range up to $\\sim$5 Mpc, contain information on the history of AGN activity in the source. They thus provide a unique opportunity to study the time scales of recurrent AGN activity. The most striking examples of recurrent activity in radio galaxies and quasars are the double-double or triple-double radio sources which contain two or three pairs of distinct lobes on opposite sides of the parent optical object. Spectral and dynamical ages of these lobes could be used to constrain time scales of episodic activity. Inverse-Compton scattered cosmic microwave background radiation could in principle probe lower Lorentz-factor particles than radio observations of synchrotron emission, and thereby reveal an older po...