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Sample records for activator trar cooperate

  1. The quorum sensing transcriptional regulator TraR has separate binding sites for DNA and the anti-activator

    Zheng, Zhida; Fuqua, Clay [Department of Molecular and Cellular Biochemistry, 212 S. Hawthorne Dr. Simon Hall 400A, Indiana University, Bloomington, IN 47405 (United States); Chen, Lingling, E-mail: linchen@indiana.edu [Department of Molecular and Cellular Biochemistry, 212 S. Hawthorne Dr. Simon Hall 400A, Indiana University, Bloomington, IN 47405 (United States)

    2012-02-10

    Highlights: Black-Right-Pointing-Pointer Quorum sensing transcription factor TraR is inhibited by forming TraR-TraM complex. Black-Right-Pointing-Pointer K213 is a key DNA binding residue, but not involved in interaction with TraM. Black-Right-Pointing-Pointer Mutations of TraM-interacting TraR residues did not affect DNA-binding of TraR. Black-Right-Pointing-Pointer Mutations of TraR residues reduced the TraR-TraM interaction more than those of TraM. Black-Right-Pointing-Pointer TraM inhibition on DNA-binding of TraR is driven by thermodynamics. -- Abstract: Quorum sensing represents a mechanism by which bacteria control their genetic behaviors via diffusible signals that reflect their population density. TraR, a quorum sensing transcriptional activator in the Rhizobiaceae family, is regulated negatively by the anti-activator TraM via formation of a TraR-TraM heterocomplex. Prior structural analysis suggests that TraM and DNA bind to TraR in distinct sites. Here we combined isothermal titration calorimetry (ITC) and electrophoretic mobility shift assays (EMSA) to investigate roles of TraR residues from Rhizobium sp. NGR234 in binding of both TraM and DNA. We found that K213A mutation of TraR{sub NGR} abolished DNA binding, however, did not alter TraM binding. Mutations of TraM-interfacing TraR{sub NGR} residues decreased the TraR-TraM interaction, but did not affect the DNA-binding activity of TraR{sub NGR}. Thus, our biochemical studies support the independent binding sites on TraR for TraM and DNA. We also found that point mutations in TraR{sub NGR} appeared to decrease the TraR-TraM interaction more effectively than those in TraM{sub NGR}, consistent with structural observations that individual TraR{sub NGR} residues contact with more TraM{sub NGR} residues than each TraM{sub NGR} residues with TraR{sub NGR} residues. Finally, we showed that TraM inhibition on DNA-binding of TraR was driven thermodynamically. We discussed subtle mechanistic differences in Tra

  2. Cooperatively active sensing system

    Aiming at development of a strong and flexible sensing system, a study on a sensing technology prepared with cooperativity, activity, and real time workability has been promoted. In the former period, together with preparation of plural moving robot group with real time processing capacity of a lot of sensor informations composing of platform, a parallel object direction language Eus Lisp effectively capable of describing and executing cooperative processing and action therewith was developed. And, it was also shown that capacity to adaptively act even at dynamic environment could be learnt experientially. And, on processing of individual sensor information, application of a photographing system with multiple resolution property similar to human visual sense property was attempted. In the latter period, together with intending of upgrading on adaptability of sensing function, by using moving robot group in center of a moving robot loaded with active visual sense, a cooperative active sensing prototype system was constructed to show effectiveness of this study through evaluation experiment of patrolling inspection at plant simulating environment. (G.K.)

  3. Theoretical Study of Molecular Determinants Involved in Signal Binding to the TraR Protein of Agrobacterium tumefaciens

    N. Kumar

    2005-10-01

    Full Text Available N-acylated homoserine lactone (AHL mediated cell-cell communication in bacteria is dependent on the recognition of the cognate signal by its receptor. This interaction allows the receptor-ligand complex to act as a transcriptional activator, controlling the expression of a range of bacterial phenotypes, including virulence factor expression and biofilm formation. One approach to determine the key features of signal- binding is to model the intermolecular interactions between the receptor and ligand using computational-based modeling software (LigandFit. In this communication, we have modeled the crystal structure of the AHL receptor protein TraR and its AHL signal N-(3- oxooctanoyl-homoserine lactone from Agrobacterium tumefaciens and compared it to the previously reported antagonist behaviour of a number of AHL analogues, in an attempt to determine structural constraints for ligand binding. We conclude that (i a common conformation of the AHL in the hydrophobic and hydrophilic region exists for ligand-binding, (ii a tail chain length threshold of 8 carbons is most favourable for ligand-binding affinity, (iii the positive correlation in the docking studies could be used a virtual screening tool.

  4. Cooperative Activities in Young Children and Chimpanzees

    Warneken, Felix; Chen, Frances; Tomasello, Michael

    2006-01-01

    Human children 18-24 months of age and 3 young chimpanzees interacted in 4 cooperative activities with a human adult partner. The human children successfully participated in cooperative problem-solving activities and social games, whereas the chimpanzees were uninterested in the social games. As an experimental manipulation, in each task the adult…

  5. The European Commission Cooperative Support Programme: Activities and Cooperation

    The International Atomic Energy Agency (IAEA) bases its technical and scientific programme on voluntary contributions from Member States, constituting the Member States Support Programme (MSSP). The European Commission Cooperative Support Programme (EC-SP) started in 1981 to support IAEA activities in the field of nuclear safeguards. Since its beginning, the EC-SP has been operated by the European Commission's Joint Research Centre in close collaboration and coordination with the European Commission's Directorate General for Energy-Directorate Nuclear Safeguards implementing the Euratom treaty. EC-SP tasks provide technology and expertise in technical areas related to the effective implementation of safeguards verification measures including the detection of undeclared materials, activities, and facilities. The EC-SP fosters cooperation with Support Programmes from European Union Member States, as well as with non-EU states with which the European Commission has specific research and development agreements, e.g., the United States Department of Energy, ABACC. Information on the research and development activities under these frameworks is shared with the IAEA and complements core EC-SP work. The paper describes the EC-SP, its modus operandi, collaborations, and main activities, namely, (a) the specific R&D work as part of tasks with well-defined milestones and deadlines, (b) training activities; (c) the technical support in establishing Safeguards guidelines and approaches and (d) the technical consultancy support to IAEA meetings and expert groups. (author)

  6. Coevolution of teaching activity promotes cooperation

    Evolutionary games are studied where the teaching activity of players can evolve in time. Initially all players following either the cooperative or defecting strategy are distributed on a square lattice. The rate of strategy adoption is determined by the payoff difference and a teaching activity characterizing the donor's capability to enforce its strategy on the opponent. Each successful strategy adoption process is accompanied by an increase in the donor's teaching activity. By applying an optimum value of the increment, this simple mechanism spontaneously creates relevant inhomogeneities in the teaching activities that support the maintenance of cooperation for both the prisoner's dilemma and the snowdrift game

  7. More Cooperative and Fitness Activities on Scooters

    Sterling, Mark A.

    2005-01-01

    This article describes both individual and team cooperative and fitness activities that can be played with scooters. The activities include but are not limited to: (1) Traffic Jam; (2) Chariot; (3) Crab Walk; (4) Pom Pom Pull Away; (5) Clothespin Hustle; (6) Four Corners; (7) Spider; (8) Carousel; (9) Amoeba; (10) Caterpillar; (11) Centipede; (12)…

  8. Coevolution of teaching activity promotes cooperation

    Szolnoki, Attila [Research Institute for Technical Physics and Materials Science, PO Box 49, H-1525 Budapest (Hungary); Perc, Matjaz [Department of Physics, Faculty of Natural Sciences and Mathematics, University of Maribor, Koroska cesta 160, SI-2000 Maribor (Slovenia)], E-mail: szolnoki@mfa.kfki.hu, E-mail: matjaz.perc@uni-mb.si

    2008-04-15

    Evolutionary games are studied where the teaching activity of players can evolve in time. Initially all players following either the cooperative or defecting strategy are distributed on a square lattice. The rate of strategy adoption is determined by the payoff difference and a teaching activity characterizing the donor's capability to enforce its strategy on the opponent. Each successful strategy adoption process is accompanied by an increase in the donor's teaching activity. By applying an optimum value of the increment, this simple mechanism spontaneously creates relevant inhomogeneities in the teaching activities that support the maintenance of cooperation for both the prisoner's dilemma and the snowdrift game.

  9. Study on cooperative active sensing system

    This study aims to develop a dispersed cooperative intellectualized system technique and a sensing system required for construction of a robot group inspectable in patrol and maintainable in selfish in a plant with large scale and complex variety. In particular, in order to establish a system with flexibility response to environment and soundness durable to abnormal accident, a cooperative active sensing technique and real-time active vision sensing technique were started. On the base of last two years results, in 1996 fiscal year, important and expansion of each element technique was conducted to start a study on movement of focussing point which was an important function of the active vision sensing. (G.K.)

  10. Study on a cooperative active sensing

    This study was made as a part of the research project ''Study on the evaluation of applicability of information collection·processing system to autonomous plant''. Previously, the basic techniques for 3-dimensional geometric modeling of working environments and for systemizing of information collection and processing have been developed. Thus, this study aimed to establish the techniques for a decentralized and cooperatively intellectualized system which allows to automatically perform patrol for inspection and maintenance in complicated plants. First, developments of cooperative active sensing for functioning in a multi-robot system and real-time active visual sensing were attempted and then the both were integrated to produce a prototype system for cooperative active sensing. The outcomes of the project in this year were as follows; a mobile platform with expanded functions, acoustic information processing, parallel EusLisp, a simulator for moving robot's behaviors, a visual monitoring system for moving objects, etc. All of these were usable for general purpose. (M.N.)

  11. Study on cooperative active sensing system

    In order to realize autonomous type nuclear plant, three-dimensional geometrical modelling method, and a basic technology on information collection and processing system preparation in some nuclear basic technology developments such as 'study on system evaluation of nuclear facility furnished with artificial intelligence for nuclear power' and 'study on adaptability evaluation of information collection and processing system into autonomous type plant' had already been developed. In this study, a study on sensing system required for constructing robot groups capable of conducting autonomously traveling inspection and maintenance in large scale, complicated and diverse plant has been processed by aiming at establishment of dispersed cooperative intelligent system technology. In 1997 fiscal year, integration of cooperative visual sensing technique was attempted. And, at the same time, upgrading of individual element technology and transportation method essential to the integrated system were investigated. As a result, an operative active sensing prototype system due to transportation robot groups furnished with real time processing capacity on diverse informations by integration of cooperative active sensing technique and real time active sensing technique developed independently plural transportation robot. (G.K.)

  12. Study on cooperative active sensing system

    Electrotechnical Laboratory is involved in the development and the improvement of three dimensional geometrical modeling for the work environment including various kinds of robots. Here, the research on the system which allows to materialize an active sensing by the cooperation of robots and the construction of an experimental system for the assessment of such modeling were reviewed. In the second stage of this project, the development of cooperative active sensory system with small size mobile robots as an operation platform was attempted. Thus, studies on the sensing techniques for robot operation and the real-time sensing techniques were started. An electric binocular head was prepared after consideration of size, cost and convenience and attached to the commercially available mobile robot base (Mouse 89, Japan System Design Co., Ltd.). The small mobile robot capable of binocular visual tracing thus obtained was confirmed to be highly efficient by various cooperative control experiments although the head was prepared at the sacrifice of control characteristics. Next, a real-time sensing system which allows to trace a moving object was constructed on the basis of Zero Disparity Filter (ZDF) produced by Kaenel et al. and further improved in the respect of the difficulty in real time processing and an expanded type ZDF was obtained. This system is routinely used as an basic vision unit for a mobile robot in the presence. (M.N.)

  13. Innovation Cooperation and Innovation Activity of Slovenian Enterprises

    Jaklič, Andreja; Jože P. Damijan; Rojec, Matija

    2008-01-01

    Innovation cooperation has been recognised as an important detfirminant of enterprises?innovation activity, productivity, and growth, and has recently become the subject of intensive research. We explore the importance of innovation cooperation for the innovation activity of Slovenian enterprises, what kind of innovation cooperation is the most 'productive?for innovation activities, and whether the location and foreign ownership of innovation cooperation matters. Probit estimations confirmed ...

  14. Cooperative activity and its potential for learning in tertiary education

    Cirila Peklaj

    2007-01-01

    Full Text Available A learning situation can be structured in different ways, as an individual, competitive, or cooperative activity. Each of these structures can be used for different purposes and can lead to different learning outcomes. This paper focuses on cooperative activity and its potential for learning in tertiary education. After defining cooperative activity (or, in a broader sense, learning in interaction and introducing the CAMS theoretical framework to analyse cooperative activity, the main discussion focuses on the theoretical reasons for the usefulness of group learning and on the research of effects of cooperative learning on cognitive (metacognitive, affective-motivational and social processes in university students. The key elements that should be established for successful cooperation are also discussed. At the end, a new direction in using cooperative activity in learning—computer supported collaborative learning (CSCL, which emerged with rapid technology development in the last two decades—is presented and discussed.

  15. Applications of cooperative games to business activities

    Rafel Amer

    2008-04-01

    Full Text Available We show several applications of the cooperative game theory and the Shapley value to business activities. Among them we emphasize on the sharing of costs or profits. In the theoretical part, the axiomatic setting proposed by Shapley is described and the properties of the value are studied. It is also shown the usefulness of simple games to describe and analyze collective decision systems ruled by voting. Many of these systems admit a representation as weighted majority games, a class of simple games. One of the most interesting problems in this case is to define a measure of the power distribution among the agents involved in the system. This problem receives a nice solution by means of the Shapley–Shubik index of power, which is the restriction of the Shapley value to simple games.

  16. Simulation of active products cooperation for active security management

    Zouinkhi, Ahmed; Ltifi, Amel; Ben Gayed, Mohamed; Abdelkrim, Naceur; Bajic, Eddy; Rondeau, Eric

    2010-01-01

    Wireless sensor networks (WSNs) are a new paradigm of telecommunication networks. WSNs are designed to perform efficient data collection and environment monitoring, among other applications. This article presents an approach of modelling and simulation of cooperation between active products that are equipped with a platform of sensor networks and ambient communication capabilities in order to increase their security, in a context of ambient intelligence of a deposit for chemical substances. T...

  17. Learning Microbiology Through Cooperation: Designing Cooperative Learning Activities that Promote Interdependence, Interaction, and Accountability

    Janine E. Trempy; Skinner, Monica M.; SIEBOLD, WILLIAM A.

    2002-01-01

    A microbiology course and its corresponding learning activities have been structured according to the Cooperative Learning Model. This course, The World According to Microbes, integrates science, math, engineering, and technology (SMET) majors and non-SMET majors into teams of students charged with problem solving activities that are microbial in origin. In this study we describe development of learning activities that utilize key components of Cooperative Learning—positive interdepende...

  18. Learning Microbiology Through Cooperation: Designing Cooperative Learning Activities that Promote Interdependence, Interaction, and Accountability

    Janine E. Trempy

    2009-12-01

    Full Text Available A microbiology course and its corresponding learning activities have been structured according to the Cooperative Learning Model. This course, The World According to Microbes, integrates science, math, engineering, and technology (SMET majors and non-SMET majors into teams of students charged with problem solving activities that are microbial in origin. In this study we describe development of learning activities that utilize key components of Cooperative Learning—positive interdependence, promotive interaction, individual accountability, teamwork skills, and group processing. Assessments and evaluations over an 8-year period demonstrate high retention of key concepts in microbiology and high student satisfaction with the course.

  19. Optimal cooperative control synthesis of active displays

    Garg, S.; Schmidt, D. K.

    1985-01-01

    A technique is developed that is intended to provide a systematic approach to synthesizing display augmentation for optimal manual control in complex, closed-loop tasks. A cooperative control synthesis technique, previously developed to design pilot-optimal control augmentation for the plant, is extended to incorporate the simultaneous design of performance enhancing displays. The technique utilizes an optimal control model of the man in the loop. It is applied to the design of a quickening control law for a display and a simple K/s(2) plant, and then to an F-15 type aircraft in a multi-channel task. Utilizing the closed loop modeling and analysis procedures, the results from the display design algorithm are evaluated and an analytical validation is performed. Experimental validation is recommended for future efforts.

  20. Which activation function of cooperation describes human behavior?

    Jarynowski, Andrzej

    2016-01-01

    Properties of cooperation's probability function in Prisoner`s Dilemma have impact on evolution of game. Basic model defines that probability of cooperation depends linearly, both on the player's altruism and the co-player's reputation. I propose modification of activation function to smooth one (hyperbolic tangent with scaling parameter a, which corresponds to its shape) and observe three phases for different range of a. (1) For small a, strategies seem to randomly change in time and situation of mixed choices (one cooperates and second defects) dominate. (2) For medium a, players choose only one strategy for given period of time (the common state can switch to opposite one with some probability). (3) For large a, mixed strategy (once defect, once cooperate) is coexisting with common strategies and no change is allowed. I believe that proposed function characterizes better socio-economical phenomena and especially phase 1 and 2 contain most of human behavior.

  1. IAEA Technical Co-operation activities: Africa

    In 1975 Tanzania became the newest African Member State of the International Atomic Energy Agency, bringing the total African membership of the Agency up to 25 countries. The other African Member States are: Algeria; United Republic of Cameroon; Egypt; Ethiopia; Gabon; Ghana; Ivory Coast; Kenya; Liberia; Libyan Arab Republic; Madagascar; Mali; Mauritius; Morocco; Niger; Nigeria; Senegal; Sierra Leone; South Africa; Sudan; Tunisia; Uganda; Zaire; Zambia. Membership of the Agency entitles these countries to receive assistance both from the Regular Programme of the Agency and from UNDP resources, while non-Member States in the region only receive Agency assistance financed from the latter source. Any attempt to look at the technical co-operation programme in Africa must start by stressing the wide differences between African countries in their level of scientific and technical development ranging from countries with advanced atomic energy programmes to countries just crossing the threshold towards the peaceful use of nuclear energy. Perhaps the most striking and marked difference is in the quality and number of nuclear energy scientists and technologists available. In view of this, the technical assistance programme in the African context has been a selective one, guided by considerations of pragmatism and responsiveness to particular requirements of the different individual countries and not by any doctrinaire or ready-made strategy for assistance. (author)

  2. The Agency's technical co-operation activities in 1992

    This report on the International Atomic Energy Agency's Technical Co-operation Activities in 1992 contains an overview of the general issues involved, including both in-house and external developments, resources and delivery, and evaluation of programs; an overview by field of activity and by division within the Agency; an overview by geographic area, distinguishing (i) Africa, (ii) Asia and the Pacific, (iii) Latin America, (iv) and the Middle East and Europe; an overview by component (i.e., experts, equipment, fellowships, training courses, sub-contracts and miscellaneous); and an overview by fund technical assistance and co-operation fund, extrabudgetary resources, United Nations Development Program (UNDP), assistance in kind. It also contains a profile on technical co-operation activities in Latin America. Projects concluded during 1992 are listed together with a description of their achievements. It concludes with implementation summaries. 10 figs, 9 tabs

  3. The Agency's technical co-operation activities in 1993

    This document reviews the IAEA's Technical Cooperation activities for 1993. Apart from an overview, the report contains reviews by Agency programmes and technical divisions, by area, by component and by fund. Summaries of project implementation are also included, as well as indications of the achievements of projects completed in 1993

  4. Visualizing Cooperative Activities with Ellimaps: The Case of Wikipedia

    Otjacques, Benoît; Cornil, Maël; Feltz, Fernand

    Cooperation has become a key word in the emerging Web 2.0 paradigm. The nature and motivations of the various behaviours related to this type of cooperative activities remain however incompletely understood. The information visualization tools can play a crucial role from this perspective to analyse the collected data. This paper presents a prototype allowing visualizing some data about the Wikipedia history with a technique called ellimaps. In this context the recent CGD algorithm is used in order to increase the scalability of the ellimaps approach.

  5. NanoSPD activity in Ufa and International Cooperation

    Reshetnikova, N.; Salakhova, M.

    2014-08-01

    This report presents main achievements of R&D activities of the Institute of Physics of Advanced Materials of Ufa State Aviation Technical University (IPAM USATU, Ufa, Russia) with a special attention to innovative potential of nanostructured metals and alloys produced by the severe plastic deformation (SPD) techniques. Several examples of the first promising applications of bulk nanostructured materials (BNM) as well as potential competing technologies are considered and discussed. The authors would like to focus special emphasis on international cooperation in view of numerous emerging projects as well as different conferences and seminars that pave the way to close and fruitful cooperation, working visits and exchange of young scientists. The possibilities of international cooperation through various foundations and programs are considered.

  6. Improving Regulatory Bodies’ Activities in Africa Through Regional Cooperation

    The Forum of Nuclear Regulatory Bodies in Africa (FNRBA) is presented as a good regional platform that plays key role in assisting the establishment of regulatory bodies and in enhancing and sustaining their activities. The FNRBA is founded on the aspirations of its members and the lessons learned from other similar regulatory networks. To achieve its objectives, the FNRBA needs more partners to learn and enhance its activities effectively, and particularly in the domain of radioactive sources control. The FNRBA is open to all nuclear regulatory bodies in the region and is voluntary. This cooperation makes use of the triangular cooperation mechanism that involves advanced and less advanced countries working together with assistance from the IAEA and other partners in development. (author)

  7. You Can Be in a Group and Still Not Cooperate. Collaborative Approaches and Cooperative Learning Activities for Adult Learners.

    Parma City School District, OH.

    This handbook defines and describes the benefits of both collaborative approaches and cooperative techniques. An introduction uses watercolor marbling as a metaphor for collaborative approaches and cooperative activities. Section I provides research results regarding problems of adult literacy programs, skills employers want, and Bloom's taxonomy.…

  8. IAEA technical co-operation activities in the 1990s

    The desire to extend the many benefits of the peaceful uses of nuclear technology to all countries led as long ago as 1957 to the establishment of the IAEA and to immediate introduction of a technical co-operation programme. In the more than thirty years that have passed since that time, the potential applications of nuclear techniques have greatly expanded. Over the period, many of the applications have moved from research laboratories into hospitals, farms and industrial enterprises. The direct resources made available to the IAEA by its Member States to support technology transfer processes have grown rapidly since the late 1950s. The current trends in the technical co-operation activities of the IAEA and some examples of projects supported by the IAEA are briefly presented in this document

  9. The European Commission Cooperative Support Programme: Activities and Achievements

    Goncalves, Joao; ABOUSAHL Said; FRIGOLA PIERRE

    2010-01-01

    The IAEA bases its technical and scientific Programme on contributions from the Member State Support Programmes (MSSP). The European Commission Cooperative Support Programme (EC-SP) started in 1981 to support IAEA¿s activities in the field of nuclear safeguards. Since its beginning, the EC-SP has been operated by the European Commission¿s Joint Research Centre (JRC) and its institutes at Ispra-Italy, Geel-Belgium and Karlsruhe-Germany. The EC-SP tasks provide technology and expertise in many ...

  10. 24 CFR 1000.240 - When is a local cooperation agreement required for affordable housing activities?

    2010-04-01

    ... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false When is a local cooperation... ACTIVITIES Indian Housing Plan (IHP) § 1000.240 When is a local cooperation agreement required for affordable housing activities? The requirement for a local cooperation agreement applies only to rental and...

  11. Cell cooperation in coelomocyte cytotoxic activity of Paracentrotus lividus coelomocytes.

    Arizza, Vincenzo; Giaramita, Francesca Tiziana; Parrinello, Daniela; Cammarata, Matteo; Parrinello, Nicolò

    2007-06-01

    The coelomic fluid from the sea urchin Paracentrotus lividus contains several coelomocyte types including amoebocytes and uncoloured spherulocytes involved in immune defences. In the present paper, we show a Ca(2+)-dependent cytotoxic activity for the unfractionated coelomocytes assayed in vitro, with rabbit erythrocytes and the K562 tumour cell line. In a plaque-forming assay, whole coelomocyte preparations as well as density gradient separated coelomocyte populations revealed that cell populations enriched in uncoloured spherulocytes, exerted high cytotoxic activity by releasing lysins in the presence of amoebocytes. This cooperative effect could be dependent on soluble factors released by amoebocytes. With regard to this, we show that an enhanced cytotoxic activity was found by adding the supernatant from sonicated amoebocytes or hemocyte culture medium into spherulocyte preparations. PMID:17329136

  12. Activation of the σE-Dependent Stress Pathway by Conjugative TraR May Anticipate Conjugational Stress

    Grace, Elicia D; Gopalkrishnan, Saumya; Girard, Mary E.; Blankschien, Matthew D.; Ross, Wilma; Gourse, Richard L.; Herman, Christophe

    2014-01-01

    Horizontal gene transfer by conjugation plays a major role in bacterial evolution, allowing the acquisition of new traits, such as virulence and resistance to antibacterial agents. With the increased antibiotic resistance in bacterial pathogens, a better understanding of how bacteria modulate conjugation under changing environments and the genetic factors involved is needed. Despite the evolutionary advantages conjugation may confer, the process can be quite stressful for the donor cell. Here...

  13. Integrating Cooperative Learning Activities to Instruction at Tertiary Education Level: A Qualitative Portrayal of the Experience

    Irshad Hussain; Dr. Hafiz Muhammad Athar Khan; Shazia Ramzan

    2013-01-01

    This paper is a qualitative portrayal of personal experience of the author in which he engaged tertiary education students in cooperative learning activities in the classroom. It is based on his observational notes taken during instructional process, involvement of learners in cooperative learning activities, and their reflection on these activities. The experience focused on assessing the effectiveness of cooperative learning activities. It is described that the researcher taught a course on...

  14. Group Solutions, Too! More Cooperative Logic Activities for Grades K-4. Teacher's Guide. LHS GEMS.

    Goodman, Jan M.; Kopp, Jaine

    There is evidence that structured cooperative logic is an effective way to introduce or reinforce mathematics concepts, explore thinking processes basic to both math and science, and develop the important social skills of cooperative problem-solving. This book contains a number of cooperative logic activities for grades K-4 in order to improve…

  15. Analysis of a Constellation Lab Cooperative Learning Activity

    Gauthier, A. J.

    2001-12-01

    A cooperative learning activity was designed for use in the undergraduate laboratory course Introduction to Astronomical Observation. This group exercise enhances the student's learning of constellations and will hopefully increase retention of the material throughout the semester. It also serves as an "ice-breaker" during the first week of lab, promoting student involvement and vested interest in the course. To gain some insight into the student mind, a survey was conducted to evaluate the usefulness and overall opinion of this method. The students who completed the survey had previously been enrolled in a pre-requisite astronomy course that also required a constellation lab. In this previous course they "learned" the constellations from an instructor and a flashlight beam, studied them on their own, and then promptly took a quiz. Both methods are analyzed from an instructional designer's point of view and suggestions for future activities are presented. The preliminary results and accompanying activity will be discussed in poster and hand-out medium.

  16. Cooperative Control Method of Active and Semiactive Control: New Framework for Vibration Control

    Kazuhiko Hiramoto

    2014-01-01

    A new control design framework for vibration control, the cooperative control of active and semiactive control, is proposed in the paper. In the cooperative control, a structural system having both of an actuator and a semiactive control device, for example, MR damper and so forth, is defined as the control object. In the proposed control approach, the higher control performance is aimed by the cooperative control between the active control with the actuator and the semiactive control with th...

  17. Using Assistive Technology Adaptations To Include Students with Learning Disabilities in Cooperative Learning Activities.

    Bryant, Diane Pedrotty; Bryant, Brian R.

    1998-01-01

    Discusses a process for integrating technology adaptations for students with learning disabilities into cooperative-learning activities in terms of three components: (1) selecting adaptations; (2) monitoring use of adaptations during cooperative-learning activities; and (3) evaluating the adaptations' effectiveness. Barriers to and support systems…

  18. 40 CFR 35.6260 - Combining Cooperative Agreement sites and activities.

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Combining Cooperative Agreement sites and activities. 35.6260 Section 35.6260 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Contracts for Superfund Response Actions Combining Cooperative Agreements § 35.6260 Combining...

  19. An Active Cooperation-Aware Spectrum Allocation Mechanism for Body Sensor Networks

    Fu Jiang

    2015-01-01

    Full Text Available A cognitive radio-based spectrum allocation scheme using an active cooperative-aware mechanism is proposed in this paper. The scheme ensures that the primary user and secondary users cooperate actively for their own benefits. The primary user releases some spectrum resources to secondary users to actively stimulate them to actively join the cooperative transmission of the primary user, and secondary users help the primary user to relay data in return, as well as its self-data transmission at the same time. The Stackelberg game is used to evenly and jointly optimize the utilities of both the primary and secondary users. Simulation results show that the proposed active cooperation-aware mechanism could improve the body sensor network performance.

  20. Dynamic instability of cooperation due to diverse activity patterns in evolutionary social dilemmas

    Xia, Cheng-Yi; Perc, Matjaz; Moreno, Yamir

    2015-01-01

    Individuals might abstain from participating in an instance of an evolutionary game for various reasons, ranging from lack of interest to risk aversion. In order to understand the consequences of such diverse activity patterns on the evolution of cooperation, we study a weak prisoner's dilemma where each player's participation is probabilistic rather than certain. Players that do not participate get a null payoff and are unable to replicate. We show that inactivity introduces cascading failures of cooperation, which are particularly severe on scale-free networks with frequently inactive hubs. The drops in the fraction of cooperators are sudden, while the spatiotemporal reorganization of compact cooperative clusters, and thus the recovery, takes time. Nevertheless, if the activity of players is directly proportional to their degree, or if the interaction network is not strongly heterogeneous, the overall evolution of cooperation is not impaired. This is because inactivity negatively affects the potency of low-...

  1. [Cooperative phenomena in the activity of single ion channels].

    Geletiuk, V I; Kazachenko, V N

    1989-01-01

    Using the patch-voltage-clamp method kinetics of the fast potential-dependent K+-channels in molluscan neurones was investigated. It was found that under given experimental conditions the amplitudes of single current impulses have a wide spectrum. The amplitudes are proportional to a number of the current substates involved. Averaged fronts of the current impulses are S-shaped, and have duration greater than 1 ms. Averaged duration of the current impulses increases (from 0.25 to 30-40 ms) with the impulse amplitude (or with the number of the substates involved). There is a sharp bend of the dependence at the impulse amplitude 0.6-0.7 of maximal value. The phenomena investigated reflect, probably, cooperativity of the channel transitions between the substates. The degree of the cooperativity depends on the membrane potential value. PMID:2804147

  2. COOPERATION WITH ASSETS MANAGEMENT COMPANIES AS THE INVESTMENT ACTIVITY OF INSURANCE COMPANIES

    Sinitsyna, T.

    2008-01-01

    The article explores the peculiarities of investment activity of local insurance companies there is analyze of one of the option using the investment opportunities of insurance companies in the way of cooperation with assets management companies.

  3. Future of international cooperative activity for graduate school education in nuclear field

    Further improvement of graduate school education in nuclear field is one of the important issues in universities in nuclear field. The COE-INES program has performed international cooperative activities for graduate school education with foreign universities in nuclear field. There are a lot of possibilities in international cooperation with foreign universities for graduate school education. The use of Internet can be a strong tool for the activities. (author)

  4. Methodical aspects of benchmarking using in Consumer Cooperatives trade enterprises activity

    Yu.V. Dvirko

    2013-01-01

    The aim of the article. The aim of this article is substantiation of benchmarking main types in Consumer Cooperatives trade enterprises activity; flashlighting of main advantages and drawbacks of benchmarking using; presentation of the authors view upon expediency of flashlighted forms of benchmarking organization using in Consumer Cooperatives in Ukraine trade enterprises activity.The results of the analysis. Under modern conditions of economic relations development and business globalizatio...

  5. Local climate activities in co-operation between municipality, civil society and science shop

    Jørgensen, Michael Søgaard

    The Science Shop at DTU co-operates with the local municipal administration and the local branch of an environmental NGO about climate change. The co-operation was initiated by a proposal to the Science Shop from the municipal administration. Since the Science Shop requests civil society involvem...... civil society has taken place in some projects. Results have been published locally and some nationally. Especially the food projects have got national interest. Co-operation about environmental impacts of municipal investments may be an up-coming activity....

  6. Power-law distributed temporal heterogeneity of human activities promotes cooperation on complex networks

    Liu, Chao; Li, Rong

    2016-09-01

    An evolutionary prisoner's dilemma game (PDG) with players located on Barabási-Albert scale-free networks is studied. The impact of players' heterogeneous temporal activity pattern on the evolution of cooperation is investigated. To this end, the normal procedure that players update their strategies immediately after a round of game is discarded. Instead, players update strategies according to their assigned reproduction time, which follows a power-law distribution. We find that the temporal heterogeneity of players' activities facilitates the prosperity of cooperation, indicating the important role of hubs in the maintenance of cooperation on scale-free networks. When the reproduction time is assigned to individuals negatively related to their degrees, a fluctuation of the cooperation level with the increase of the exponent β is observed.

  7. Activities of technical cooperation in the countries of Latin America: the case of Costa Rica

    The activities of technical cooperation in the region of Latin America, have been promoted by the own countries, and by the International Atomic Energy Agency, since 1957. In Costa Rica from 1969, the Commission of Atomic Energy of Costa Rica, has developed an intense work in the promotion of the pacific uses of nuclear energy, as well as, the coordination and canalization of the international technical cooperation, toward the national executing institutions. (author)

  8. Design Activities in the NorwegianSeafood Industry: A theoretical approach to understanding cooperation and communication

    Schulte, Kjersti Øverbø

    2009-01-01

    The thesis discusses design activities in the Norwegian seafood processing industry, with focus on cooperation between packaging suppliers and designers. There is a twofold objective: to increase understanding of how industrial design methodology can be utilised in the seafood industry, and to introduce a theoretical foundation for cooperation and communication in industrial design methodology.Sales of fish and seafood represent Norway’s third largest export. Seafood is an industrially proces...

  9. Interhemispheric cooperation and activation in integration of verbal information.

    Berger, J M

    1988-08-01

    Subjects had to judge the semantic relation between two tachistoscopically presented German adjectives. In Exp. I, the two words were projected simultaneously, either both to the left visual field (i.e. to the right hemisphere, LVF-RH), or both to the right visual field (i.e. to the left hemisphere, RVF-LH), or one word to each visual field (i.e. to both hemispheres, EVF-BH). The results yielded a significantly higher performance in the condition EVF-BH than in the two unilateral conditions, without a significant difference between the latter two conditions. In Exp. II, the two words were shown successively. With bilateral presentation, a distinction was made as to whether the left visual field (EVF-BH-L) or the right visual field (EVF-BH-R) was stimulated first. The significantly highest performance was shown in conditions RVF-LH and EVF-BH-R compared with the condition EVF-BH-L, and the significantly poorest performance in the condition LVF-RH compared with the condition EVF-BH-L. The results provide evidence for (1) an intrahemispheric interference with simultaneous unilateral presentation, (2) a cooperative interhemispheric interaction with simultaneous bilateral presentation, and (3) an interhemispheric priming effect with successive bilateral presentation when the left hemisphere was stimulated first. PMID:3166698

  10. Features of the organization of separate accounting of income and expenses from business and statutory activities of the dwelling-construction cooperative

    Diana Ildusovna Khairullina

    2015-01-01

    Objective to reveal the need for separate accounting of income and expenses from business and statutory activities of dwellingconstruction cooperative. Methods in this work the abstractlogical method of research has been applied. Results basing on the analysis of normativelegal documents regulating the activities of dwellingconstruction cooperatives the business activities of cooperatives were determined the income and expenses received by the cooperative from business activ...

  11. Cooperation between core promoter elements influences transcriptional activity in vivo.

    Colgan, J.; Manley, J L

    1995-01-01

    Core promoters for RNA polymerase II frequently contain either (or both) of two consensus sequence elements, a TATA box and/or an initiator (Inr). Using test promoters consisting of prototypical TATA and/or Inr elements, together with binding sites for sequence-specific activators, we have analyzed the function of TATA and Inr elements in vivo. In the absence of activators, the TATA element was significantly more active than the Inr, and the combination of elements was only slightly more effe...

  12. Methods for the evaluation of hospital cooperation activities (Systematic review protocol

    Rotter Thomas

    2012-02-01

    Full Text Available Abstract Background Hospital partnerships, mergers and cooperatives are arrangements frequently seen as a means of improving health service delivery. Many of the assumptions used in planning hospital cooperatives are not stated clearly and are often based on limited or poor scientific evidence. Methods This is a protocol for a systematic review, following the Cochrane EPOC methodology. The review aims to document, catalogue and synthesize the existing literature on the reported methods for the evaluation of hospital cooperation activities as well as methods of hospital cooperation. We will search the Database of Abstracts of Reviews of Effectiveness, the Effective Practice and Organisation of Care Register, the Cochrane Central Register of Controlled Trials and bibliographic databases including PubMed (via NLM, Web of Science, NHS EED, Business Source Premier (via EBSCO and Global Health for publications that report on methods for evaluating hospital cooperatives, strategic partnerships, mergers, alliances, networks and related activities and methods used for such partnerships. The method proposed by the Cochrane EPOC group regarding randomized study designs, controlled clinical trials, controlled before and after studies, and interrupted time series will be followed. In addition, we will also include cohort, case-control studies, and relevant non-comparative publications such as case reports. We will categorize and analyze the review findings according to the study design employed, the study quality (low versus high quality studies and the method reported in the primary studies. We will present the results of studies in tabular form. Discussion Overall, the systematic review aims to identify, assess and synthesize the evidence to underpin hospital cooperation activities as defined in this protocol. As a result, the review will provide an evidence base for partnerships, alliances or other fields of cooperation in a hospital setting. PROSPERO

  13. Cooperative Self-Propulsion of Active and Passive Rotors

    Fily, Yaouen; Baskaran, Aparna; Marchetti, M. Cristina

    2011-01-01

    Using minimal models for low Reynolds number passive and active rotors in a fluid, we characterize the hydrodynamic interactions among rotors and the resulting dynamics of a pair of interacting rotors. This allows us to treat in a common framework passive or externally driven rotors, such as magnetic colloids driven by a rotating magnetic field, and active or internally driven rotors, such as sperm cells confined at boundaries. The hydrodynamic interaction of passive rotors is known to contai...

  14. Cooperative activation of transcription by autoimmune regulator AIRE and CBP

    Autoimmune regulator (AIRE) is a transcriptional regulator that is believed to control the expression of tissue-specific genes in the thymus. Mutated AIRE is responsible for onset of the hereditary autoimmune disease APECED. AIRE is able to form nuclear bodies (NBs) and interacts with the ubiquitous transcriptional coactivator CBP. In this paper, we show that CBP and AIRE synergistically activate transcription on different promoter reporters whereas AIRE gene mutation R257X, found in APECED patients, interferes with this coactivation effect. Furthermore, the overexpression of AIRE and CBP collaboratively enhance endogenous IFNβ mRNA expression. The immunohistochemical studies suggest that CBP, depending on the balance of nuclear proteins, is a component of AIRE NBs. We also show that AIRE NBs are devoid of active chromatin and, therefore, not sites of transcription. In addition, we demonstrate by 3D analyses that AIRE and CBP, when colocalizing, are located spatially differently within AIRE NBs. In conclusion, our data suggest that AIRE activates transcription of the target genes, i.e., autoantigens in collaboration with CBP and that this activation occurs outside of AIRE NBs

  15. The verification of neutron activation analysis support system (cooperative research)

    Neutron activation analysis support system is the system in which even the user who has not much experience in the neutron activation analysis can conveniently and accurately carry out the multi-element analysis of the sample. In this verification test, subjects such functions, usability, precision and accuracy of the analysis and etc. of the neutron activation analysis support system were confirmed. As a method of the verification test, it was carried out using irradiation device, measuring device, automatic sample changer and analyzer equipped in the JRR-3M PN-3 facility, and analysis software KAYZERO/SOLCOI based on the k0 method. With these equipments, calibration of the germanium detector, measurement of the parameter of the irradiation field and analysis of three kinds of environmental standard sample were carried out. The k0 method adopted in this system is primarily utilized in Europe recently, and it is the analysis method, which can conveniently and accurately carried out the multi-element analysis of the sample without requiring individual comparison standard sample. By this system, total 28 elements were determined quantitatively, and 16 elements with the value guaranteed as analytical data of the NIST (National Institute of Standards and Technology) environment standard sample were analyzed in the accuracy within 15%. This report describes content and verification result of neutron activation support system. (author)

  16. Methodical aspects of benchmarking using in Consumer Cooperatives trade enterprises activity

    Yu.V. Dvirko

    2013-03-01

    Full Text Available The aim of the article. The aim of this article is substantiation of benchmarking main types in Consumer Cooperatives trade enterprises activity; flashlighting of main advantages and drawbacks of benchmarking using; presentation of the authors view upon expediency of flashlighted forms of benchmarking organization using in Consumer Cooperatives in Ukraine trade enterprises activity.The results of the analysis. Under modern conditions of economic relations development and business globalization big companies, enterprises, organizations realize the necessity of the thorough and profound research of the best achievements of market subjects relations with their further using in their own activity. Benchmarking is the process of competitive advantages borrowing and competitiveness increasing of Consumer Cooperatives trade enterprises at the expense of research leaning and adapting the best methods of business processes realization with the purpose to increase their functioning affectivity and best satisfaction of societal needs.The main goals of benchmarking using in Consumer Cooperatives are the following: increasing of needs satisfaction level at the expense of products quality increasing, transportation goods term shortening, service quality increasing; enterprise potential strengthening, competitiveness strengthening, image improvement; generation and new ideas and innovative decisions implementation in trade enterprise activity. The advantages of benchmarking using in Consumer Cooperatives trade enterprises activity are the following: adapting the parameters of enterprise functioning to market demands; gradual defining and removing inadequacies which obstacle enterprise development; borrowing the best methods of further enterprise development; competitive advantages gaining; technological innovations; employees motivation. Authors classification of benchmarking is represented by the following components: by cycle durability strategic, operative

  17. 40 CFR 35.6150 - Activities eligible for funding under enforcement Cooperative Agreements.

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Activities eligible for funding under enforcement Cooperative Agreements. 35.6150 Section 35.6150 Protection of Environment ENVIRONMENTAL PROTECTION... Agreement application from a State, political subdivision or Indian Tribe may request funding for...

  18. Impact of heterogeneous activity and community structure on the evolutionary success of cooperators in social networks

    Wu, Zhi-Xi; Rong, Zhihai; Yang, Han-Xin

    2015-01-01

    Recent empirical studies suggest that heavy-tailed distributions of human activities are universal in real social dynamics [L. Muchnik, S. Pei, L. C. Parra, S. D. S. Reis, J. S. Andrade Jr., S. Havlin, and H. A. Makse, Sci. Rep. 3, 1783 (2013), 10.1038/srep01783]. On the other hand, community structure is ubiquitous in biological and social networks [M. E. J. Newman, Nat. Phys. 8, 25 (2012), 10.1038/nphys2162]. Motivated by these facts, we here consider the evolutionary prisoner's dilemma game taking place on top of a real social network to investigate how the community structure and the heterogeneity in activity of individuals affect the evolution of cooperation. In particular, we account for a variation of the birth-death process (which can also be regarded as a proportional imitation rule from a social point of view) for the strategy updating under both weak and strong selection (meaning the payoffs harvested from games contribute either slightly or heavily to the individuals' performance). By implementing comparative studies, where the players are selected either randomly or in terms of their actual activities to play games with their immediate neighbors, we figure out that heterogeneous activity benefits the emergence of collective cooperation in a harsh environment (the action for cooperation is costly) under strong selection, whereas it impairs the formation of altruism under weak selection. Moreover, we find that the abundance of communities in the social network can evidently foster the formation of cooperation under strong selection, in contrast to the games evolving on randomized counterparts. Our results are therefore helpful for us to better understand the evolution of cooperation in real social systems.

  19. The Agency's Technical Co-operation activities in 1987. Report by the Director General

    This report is part of a wide range of documentation which the Agency provides to Member States on its technical co-operation activities at various times during the year. It is, in particular, complemented by the achievement reporting submitted to the Technical Assistance and Co-operation Committee of the Board in the annual implementation reports that give the status of the technical co-operation programmes as at 30 September in each year. Following the 1986 Technical Co-operation Seminar and based on continuing consultations with Member States various steps to improve the quality of the programme were taken in 1987: for example, new project request forms and management plans were introduced and preparatory assistance was expanded. Office automation was intensified and the computerized data base covering technical co-operation was enhanced further. Work continues on the adaptation of data provided by the new Financial Information and Control System (FIGS) to the needs of the technical co-operation programmes and vice-versa. While several problems have still to be overcome, it has on the whole, been possible in this report to re-establish data comparability with previous years. Evaluation has become an integral part of the Agency's technical cooperation activities. In addition to on-going mid-project and end-of-project evaluations, expert services and fellowships were evaluated in 1987 and the first country programme evaluation was also undertaken. During 1987, a total of 962 projects were operational and 64 training courses were held. These activities involved 1808 expert assignments while 1975 persons received training abroad. Of the provisions in the 1987 total adjusted programme, one half was earmarked for equipment, while the other half was equally divided between ear markings for experts and for training. Of the Agency's technical co-operation resources in 1987, 72.5% came from the Technical Assistance and Co-operation Fund, 13.7% from extra budgetary

  20. Active Learning and Cooperative Learning in the Organic Chemistry Lecture Class

    Paulson, Donald R.

    1999-08-01

    Faculty in the physical sciences are one of the academic groups least receptive to the use of active learning strategies and cooperative learning in their classrooms. This is particularly so in traditional lecture classes. It is the objective of this paper to show how effective these techniques can be in improving student performance in classes. The use of active learning strategies and cooperative learning groups in my organic chemistry lecture classes has increased the overall pass rate in my classes by an astounding 20-30% over the traditional lecture mode. This has been accomplished without any reduction in "standards". The actual methods employed are presented as well as a discussion of how I came to radically change the way I teach my classes.

  1. CEDEX's supporting activities through the Cooperation fund for Water and Sanitation

    This paper deals with the activities CEDEX has being doing since 2012, Giving Technical support to the cooperation fund for Water and Sanitation (Fondo de Cooperacion para Agua y Saneamiento-FCAS), of the Spanish Agency for International Development Cooperation. Throughout the document, the different activities carried out by the CEDEX up to now, are briefly described. They have mainly consisted in giving technical support during the formulation, review and monitoring of the tasks derived from the FCAS programs, capacity buildings, and preparing technical guides and recommendations concerning different subjects. The FCAS programs concerns water planning water supply and sanitation planning as well as water supply and sanitation (sewerage and wastewater treatment plants) construction projects. The paper ends up presenting a set of conclusions and lessons learned extracted from this period working for the FCAS, as well as the main courses of action projected for the future collaboration works. (Author)

  2. Cooperative Control of Active Power Filters in Power Systems without Mutual Communication

    Tlustý, J.; Škramlík, Jiří; Švec, J.; Valouch, Viktor

    2010-01-01

    Roč. 2010, č. 517184 (2010), s. 1-13. ISSN 1024-123X R&D Projects: GA AV ČR IAA200760703 Institutional research plan: CEZ:AV0Z20570509 Keywords : active power filter * power system * wireless cooperation Subject RIV: JA - Electronics ; Optoelectronics, Electrical Engineering Impact factor: 0.689, year: 2010 http://www.hindawi.com/journals/mpe/2010/517184.html

  3. co-Laevo - Supporting Cooperating Teams by Working 'within' Shared Activity Time Lines

    Jeuris, Steven; Tell, Paolo; Bardram, Jakob

    2016-01-01

    -alone scheduling tools, like a team calendar, the actual work is not disconnected from the plan. In essence, users work ‘within’ a shared schedule, suspending and resuming activity workspaces in order to access the contained resources required for their work. Users are thereby constantly confronted with their own......In this paper, we describe the interaction design and implementation of co-Laevo: an activity-centric desktop computing system supporting task coordination within cooperating teams. Coordination is supported by having all team members orchestrate their dependent tasks on a shared activity time line....... Each task (or activity) is associated with a personal dedicated workspace within which related resources, like files and windows, are embedded. As users access activity workspaces, the past, current, and planned state of the activity can be updated to reflect ongoing work. In contrast to stand...

  4. The Agency's Technical Co-operation activities in 1984. Report by the Director General

    The year 1984 can be described as one during which efforts were made to increase momentum in the development co-operation between the Agency and its Member States while continuing to improve the quality of the technical assistance rendered. For the first time, the adjusted programme exceeded $50 million. During the year, changes were introduced in the administration of the programme in line with recommendations endorsed by the Board in 1983 at the end of its first technical co-operation policy review. In 1984, when the new technical co-operation policies were applied, there were three principal aims. First, the flow of Technical Assistance and Co-operation Fund resources was to be improved; by decreasing accumulated unobligated balances, an optimum level of resource utilization was to be attained by 1986. Second, procedures for the procurement of goods and services were to be streamlined in order to permit substantial increases in programme delivery. Third, systematic project evaluation was to lead to a number of specific actions that would increase the effectiveness of the Agency's development assistance. With regard to the first aim, implementation increased by 44% over the 1983 level, passing the $30 million mark in October and reaching $36.6 million by the end of the year. Of this amount, $31.8 million related to the implementation of activities programmed for 1984. Therefore, an increase in total resources of only 4% was accompanied by an increase in current-year implementation of 34%. As a result, the upward trend in the unobligated balance was checked, and earmarkings against the TACF actually decreased. The implementation rate against the TACF rose from 58% in 1983 to 65% in 1984, reaching the level that had been set as a target. If this performance can be maintained in 1985, it will be possible to reach the optimum level of TACF resource utilization one year earlier than originally expected. As regards the second aim, streamlined procedures introduced in

  5. THE SOCIAL ORIENTATION OF THE ACTIVITY OF THE LABOUR WORKING COOPERATIVES FOR DISABLED PEOPLE IN BULGARIA

    Albena MITEVA

    2014-04-01

    Full Text Available Bulgaria's membership in the European Union defines the orientation of our country in line with the key strategic priorities of Europe 2020, which aims to achieve smart, sustainable and inclusive growth. The role of the cooperative system becomes especially important at this time when the EU itself is constructed as a union of equal socially oriented states. In the paper is depicted the role of the labour working producer cooperatives for disabled people as one of the main actors of the social economy in the EU which contribute to solving many economic and social problems of a substantial part of the Bulgarian population and to implement the priorities of the strategy "Europe 2020". In line with this aim, are given suggestion for the trends in improving their activity. So that they could provide better labour rehabilitation, strengthen the social integration of their members, promotion of production, improvement of working conditions, proposals for changes in legislation.

  6. Throughput Maximization for Cognitive Radio Networks Using Active Cooperation and Superposition Coding

    Hamza, Doha

    2015-02-13

    We propose a three-message superposition coding scheme in a cognitive radio relay network exploiting active cooperation between primary and secondary users. The primary user is motivated to cooperate by substantial benefits it can reap from this access scenario. Specifically, the time resource is split into three transmission phases: The first two phases are dedicated to primary communication, while the third phase is for the secondary’s transmission. We formulate two throughput maximization problems for the secondary network subject to primary user rate constraints and per-node power constraints with respect to the time durations of primary transmission and the transmit power of the primary and the secondary users. The first throughput maximization problem assumes a partial power constraint such that the secondary power dedicated to primary cooperation, i.e. for the first two communication phases, is fixed apriori. In the second throughput maximization problem, a total power constraint is assumed over the three phases of communication. The two problems are difficult to solve analytically when the relaying channel gains are strictly greater than each other and strictly greater than the direct link channel gain. However, mathematically tractable lowerbound and upperbound solutions can be attained for the two problems. For both problems, by only using the lowerbound solution, we demonstrate significant throughput gains for both the primary and the secondary users through this active cooperation scheme. We find that most of the throughput gains come from minimizing the second phase transmission time since the secondary nodes assist the primary communication during this phase. Finally, we demonstrate the superiority of our proposed scheme compared to a number of reference schemes that include best relay selection, dual-hop routing, and an interference channel model.

  7. Conflictual cooperation

    Axel, Erik

    2011-01-01

    This paper explores cooperation as contradictory and therefore with a constant possibility for conflict. Consequently it is called conflictual cooperation. The notion is presented on the basis of a participatory observation in a control room of a district heating system. In the investigation......, cooperation appeared as the continuous reworking of contradictions in the local arrangement of societal con- ditions. Subjects were distributed and distributed themselves according to social privileges, resources, and dilemmas in cooperation. Here, the subjects’ activities and understandings took form from...... regulating who can use what in what way. Contradictions in the observed activity are discussed. It is argued that for the participants the connec- tions of acts appear in such contradictions in cooperation. This conception is dis- cussed in relationship to the notions of practice, as expounded by Bourdieu...

  8. The use of learning technologies in cooperation during the organization of practical activities of students at the lessons of biology

    Natalia Bobrova

    2014-06-01

    Full Text Available The author considers the technology of education in cooperation of teacher and student and its implications in the organization of practical activity of pupils at lessons of biology, in particular in teaching workshops.

  9. A proposal for cooperative activities between Japan and Indonesia in the field of nuclear research and nuclear education

    Development and realization of cooperative activities between Japan and Indonesia in nuclear research and education is indeed very important for scientists and engineers of both countries. This bilateral cooperation can easily be expanded into a regional cooperation benefiting the scholars from Asian region which is expecting a New Nuclear Age in the 21st Century. To develop and realize this cooperative activities, in the first step, we invite the ideas of our partners in the Nuclear Institution and in Universities. They are eager to have and undertake this cooperation effort. For nuclear research activities, they have proposed several topics which include: advanced radioactive waste technology and management in a nuclear power plant, innovative fuel development for LWR's, gas cooled reactor for electricity and hydrogen production and a topic on design and construction of high energy accelerator. Institute of Technology - Bandung (ITB), University of Gajah Mada (UGM) and School of Nuclear Technology (STTN/BATAN) are interested in cooperative works which include: joint development of standard curriculum for M.Sc. level in response to increased activities in nuclear research and nuclear power development, exchange of guest lecturers, and exchange of M.Sc. level students. With this cooperation, we want to put very special emphasis on nuclear human resources development (nuclear - HRD) in anticipation of the upcoming nuclear era. (author)

  10. Patient-cooperative control increases active participation of individuals with SCI during robot-aided gait training

    Duschau-Wicke Alexander

    2010-09-01

    Full Text Available Abstract Background Manual body weight supported treadmill training and robot-aided treadmill training are frequently used techniques for the gait rehabilitation of individuals after stroke and spinal cord injury. Current evidence suggests that robot-aided gait training may be improved by making robotic behavior more patient-cooperative. In this study, we have investigated the immediate effects of patient-cooperative versus non-cooperative robot-aided gait training on individuals with incomplete spinal cord injury (iSCI. Methods Eleven patients with iSCI participated in a single training session with the gait rehabilitation robot Lokomat. The patients were exposed to four different training modes in random order: During both non-cooperative position control and compliant impedance control, fixed timing of movements was provided. During two variants of the patient-cooperative path control approach, free timing of movements was enabled and the robot provided only spatial guidance. The two variants of the path control approach differed in the amount of additional support, which was either individually adjusted or exaggerated. Joint angles and torques of the robot as well as muscle activity and heart rate of the patients were recorded. Kinematic variability, interaction torques, heart rate and muscle activity were compared between the different conditions. Results Patients showed more spatial and temporal kinematic variability, reduced interaction torques, a higher increase of heart rate and more muscle activity in the patient-cooperative path control mode with individually adjusted support than in the non-cooperative position control mode. In the compliant impedance control mode, spatial kinematic variability was increased and interaction torques were reduced, but temporal kinematic variability, heart rate and muscle activity were not significantly higher than in the position control mode. Conclusions Patient-cooperative robot-aided gait training

  11. Active and Cooperative Learning Paths in the Pigelleto's Summer School of Physics

    Benedetti, Roberto; Montalbano, Vera; Porri, Antonella

    2012-01-01

    Since 2006, the Pigelleto's Summer School of Physics is an important appointment for orienting students toward physics. It is organized as a full immersion school on actual topics in physics or in fields rarely pursued in high school, i.e. quantum mechanics, new materials, energy resources. The students, usually forty, are engaged in many activities in laboratory and forced to become active participants. Furthermore, they are encouraged in cooperating in small groups in order to present and share the achieved results. In the last years, the school became a training opportunity for younger teachers which are involved in programming and realization of selected activities. The laboratory activities with students are usually supervised by a young and an expert teacher in order to fix the correct methodology.

  12. Benchmarking the Fertilizer and Crop Protectant Application Activities of Agricultural Cooperatives

    Ouedraogo, Frederic; Phillip, Kenkel

    2015-01-01

    This research aims to benchmark agricultural supply cooperatives regarding their fertilizer application services. Cooperative fertilizer application departments are essentially an extension of member farm operations. Because farm supply cooperatives return profits to their user members, the efficiency of the application department directly impacts farm profitability. Therefore, a benchmark analysis is needed to compare performances among competitive cooperatives, identify the best practices, ...

  13. Cross-sector cooperation in health-enhancing physical activity policymaking: more potential than achievements?

    Hämäläinen, Riitta-Maija; Aro, Arja R; Lau, Cathrine Juel; Rus, Diana; Cori, Liliana; Syed, Ahmed M.; ,

    2016-01-01

    Background The cooperation of actors across policy fields and the need for cross-sector cooperation as well as recommendations on how to implement cross-sector cooperation have been addressed in many national and international policies that seek to solve complex issues within societies. For such a purpose, the relevant governance structure between policy sectors is cross-sector cooperation. Therefore, cross-sector cooperation and its structures need to be better understood for improved implem...

  14. Co-operative Banking Groups in Europe: Comparative Analysis of the Structure and Activity

    Ricardo J. Palomo Zurdo

    2008-01-01

    The aim of this paper is to show the situation of the main European co-operative banking groups (or systems) through the analysis of particular aspects of their structure and the activities and services they offer, in order to compare these groups with the Spanish case to check if the different ways of dealing with these aspects agree, and under what circumstances or how they are developed. This analysis is also intended to identify the decision-making and economic linking relations set up be...

  15. An fMRI study of joint action–varying levels of cooperation correlates with activity in control networks

    Chaminade, Thierry; Marchant, Jennifer L.; Kilner, James; Frith, Christopher D.

    2012-01-01

    As social agents, humans continually interact with the people around them. Here, motor cooperation was investigated using a paradigm in which pairs of participants, one being scanned with fMRI, jointly controlled a visually presented object with joystick movements. The object oscillated dynamically along two dimensions, color and width of gratings, corresponding to the two cardinal directions of joystick movements. While the overall control of each participant on the object was kept constant, the amount of cooperation along the two dimensions varied along four levels, from no (each participant controlled one dimension exclusively) to full (each participant controlled half of each dimension) cooperation. Increasing cooperation correlated with BOLD signal in the left parietal operculum and anterior cingulate cortex (ACC), while decreasing cooperation correlated with activity in the right inferior frontal and superior temporal gyri, the intraparietal sulci and inferior temporal gyri bilaterally, and the dorsomedial prefrontal cortex. As joint performance improved with the level of cooperation, we assessed the brain responses correlating with behavior, and found that activity in most of the areas associated with levels of cooperation also correlated with the joint performance. The only brain area found exclusively in the negative correlation with cooperation was in the dorso medial frontal cortex, involved in monitoring action outcome. Given the cluster location and condition-related signal change, we propose that this region monitored actions to extract the level of cooperation in order to optimize the joint response. Our results, therefore, indicate that, in the current experimental paradigm involving joint control of a visually presented object with joystick movements, the level of cooperation affected brain networks involved in action control, but not mentalizing. PMID:22715326

  16. An fMRI study of joint action-varying levels of cooperation correlates with activity in control networks.

    Chaminade, Thierry; Marchant, Jennifer L; Kilner, James; Frith, Christopher D

    2012-01-01

    As social agents, humans continually interact with the people around them. Here, motor cooperation was investigated using a paradigm in which pairs of participants, one being scanned with fMRI, jointly controlled a visually presented object with joystick movements. The object oscillated dynamically along two dimensions, color and width of gratings, corresponding to the two cardinal directions of joystick movements. While the overall control of each participant on the object was kept constant, the amount of cooperation along the two dimensions varied along four levels, from no (each participant controlled one dimension exclusively) to full (each participant controlled half of each dimension) cooperation. Increasing cooperation correlated with BOLD signal in the left parietal operculum and anterior cingulate cortex (ACC), while decreasing cooperation correlated with activity in the right inferior frontal and superior temporal gyri, the intraparietal sulci and inferior temporal gyri bilaterally, and the dorsomedial prefrontal cortex. As joint performance improved with the level of cooperation, we assessed the brain responses correlating with behavior, and found that activity in most of the areas associated with levels of cooperation also correlated with the joint performance. The only brain area found exclusively in the negative correlation with cooperation was in the dorso medial frontal cortex, involved in monitoring action outcome. Given the cluster location and condition-related signal change, we propose that this region monitored actions to extract the level of cooperation in order to optimize the joint response. Our results, therefore, indicate that, in the current experimental paradigm involving joint control of a visually presented object with joystick movements, the level of cooperation affected brain networks involved in action control, but not mentalizing. PMID:22715326

  17. Goals and activities of the JICA technical cooperation project on reduction of seismic risk in Romania

    Japan International Cooperation Agency (JICA) Technical Cooperation Project on Reduction of Seismic Risk for Buildings and Structures started in Romania on October 1, 2002. The aim of the Project is to strengthen the capacity of earthquake disaster related activities in Romania. The Project approval is the result of four years of intensive efforts made by professionals from Technical University of Civil Engineering Bucharest (UTCB), Ministry of Transport, Constructions and Tourism (MTCT), Romania, National Building Research Institute (INCERC) Bucharest, JICA, Building Research Institute (BRI), Tsukuba, and National Institute for Land, Infrastructure and Management (NILIM), Tsukuba, Japan. The duration of the Project is five years. The implementing agency is the National Center for Seismic Risk Reduction (NCSRR) as a public institution of national interest under MTCT. The activities are carried out by NCSRR in partnership with UTCB and INCERC. During the Project period, 29 young Romanian engineers were trained in Japan, 7 Japanese experts and 37 Japanese experts worked for long-term and short-term, respectively in Romania. Equipment for seismic instrumentation, dynamic characterization of soil and structural testing rising up approximately to 260 million yens (i.e. 2.17 million USD) were donated by JICA to Romania, through NCSRR. The total cost of the Project is roughly 7 million USD. The paper describes the main activities and results of the Project until the JICA Final Evaluation Mission (March 2007). (authors)

  18. The Agency's Technical Co-operation activities in 1986. Report by the Director General

    During 1986, a total of 854 projects were operational and 71 training courses were held. These activities involved 1930 expert assignments. In addition, 937 persons received training under the fellowship programme. Performance indicators (non-financial) are given in Part II of this report (Sections B and C) in order to provide some impression of the increase in implementation actions related to the delivery of a growing programme. Although total resources were higher in 1986 than in previous years, the overall growth rate declined further while new obligations and disbursements increased steeply. The near-stagnation in the net expenditure rate for Technical Assistance and Co-operation Fund (TACF) resources which occurred in 1985 prompted close monitoring and follow-up measures in 1986. These actions led to an all-time high TACF net expenditure rate, namely 75.7%, in 1986. As the TACF represented 71% of all technical co-operation resources, overall programme performance in terms of net expenditure reached 67.6%, which is also the highest rate ever recorded. TACF resources increased by 11%. Pledges and miscellaneous income covered 92.7% of the target. The percentage attainment of the target has been declining since 1983. As actual disbursements against the TACF increased at a much higher rate than new resources, the unobligated balance decreased to the extent that striving for even higher net expenditure rates would no longer be consistent with judicious resource management. The share of extrabudgetary funds in the programme declined: they accounted for 14.5% of the resources and 12.6% of the disbursements in 1986. The Federal Republic of Germany became the largest contributor of extrabudgetary funds. Special attention will be given to the utilization of these resources so that delivery rates can be improved. As anticipated, UNDP's share in resources and disbursements increased and several new large-scale projects were approved. In-kind assistance continued to play a

  19. Structural Basis for a Reciprocating Mechanism of Negative Cooperativity in Dimeric Phosphagen Kinase Activity

    Wu, X.; Ye, S; Guo, S; Yan, W; Bartlam, M; Rao, Z

    2010-01-01

    Phosphagen kinase (PK) family members catalyze the reversible phosphoryl transfer between phosphagen and ADP to reserve or release energy in cell energy metabolism. The structures of classic quaternary complexes of dimeric creatine kinase (CK) revealed asymmetric ligand binding states of two protomers, but the significance and mechanism remain unclear. To understand this negative cooperativity further, we determined the first structure of dimeric arginine kinase (dAK), another PK family member, at 1.75 {angstrom}, as well as the structure of its ternary complex with AMPPNP and arginine. Further structural analysis shows that the ligand-free protomer in a ligand-bound dimer opens more widely than the protomers in a ligand-free dimer, which leads to three different states of a dAK protomer. The unexpected allostery of the ligand-free protomer in a ligand-bound dimer should be relayed from the ligand-binding-induced allostery of its adjacent protomer. Mutations that weaken the interprotomer connections dramatically reduced the catalytic activities of dAK, indicating the importance of the allosteric propagation mediated by the homodimer interface. These results suggest a reciprocating mechanism of dimeric PK, which is shared by other ATP related oligomeric enzymes, e.g., ATP synthase. - Wu, X., Ye, S., Guo, S., Yan, W., Bartlam, M., Rao, Z. Structural basis for a reciprocating mechanism of negative cooperativity in dimeric phosphagen kinase activity.

  20. Synergistic cooperation of MDM2 and E2F1 contributes to TAp73 transcriptional activity

    Kasim, Vivi, E-mail: vivikasim78@gmail.com [The Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400044 (China); Huang, Can; Zhang, Jing; Jia, Huizhen; Wang, Yunxia [The Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400044 (China); Yang, Li [The Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400044 (China); The 111 Project Laboratory of Biomechanics and Tissue Repair, College of Bioengineering, Chongqing University, Chongqing 400044 (China); Miyagishi, Makoto [Molecular Composite Medicine Research Group, Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba 305-8566 (Japan); Wu, Shourong, E-mail: shourongwu@hotmail.com [The Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400044 (China); The 111 Project Laboratory of Biomechanics and Tissue Repair, College of Bioengineering, Chongqing University, Chongqing 400044 (China)

    2014-07-04

    Highlights: • MDM2 is a novel positive regulator of TAp73 transcriptional activity. • MDM2 colocalizes together and physically interacts with E2F1. • Synergistic cooperation of MDM2 and E2F1 is crucial for TAp73 transcription. • MDM2 regulates TAp73 transcriptional activity in a p53-independent manner. - Abstract: TAp73, a structural homologue of p53, plays an important role in tumorigenesis. E2F1 had been reported as a transcriptional regulator of TAp73, however, the detailed mechanism remains to be elucidated. Here we reported that MDM2-silencing reduced the activities of the TAp73 promoters and the endogenous TAp73 expression level significantly; while MDM2 overexpression upregulated them. We further revealed that the regulation of TAp73 transcriptional activity occurs as a synergistic effect of MDM2 and E2F1, most probably through their physical interaction in the nuclei. Furthermore, we also suggested that MDM2 might be involved in DNA damage-induced TAp73 transcriptional activity. Finally, we elucidated that MDM2-silencing reduced the proliferation rate of colon carcinoma cells regardless of the p53 status. Our data show a synergistic effect of MDM2 and E2F1 on TAp73 transcriptional activity, suggesting a novel regulation pathway of TAp73.

  1. Synergistic cooperation of MDM2 and E2F1 contributes to TAp73 transcriptional activity

    Highlights: • MDM2 is a novel positive regulator of TAp73 transcriptional activity. • MDM2 colocalizes together and physically interacts with E2F1. • Synergistic cooperation of MDM2 and E2F1 is crucial for TAp73 transcription. • MDM2 regulates TAp73 transcriptional activity in a p53-independent manner. - Abstract: TAp73, a structural homologue of p53, plays an important role in tumorigenesis. E2F1 had been reported as a transcriptional regulator of TAp73, however, the detailed mechanism remains to be elucidated. Here we reported that MDM2-silencing reduced the activities of the TAp73 promoters and the endogenous TAp73 expression level significantly; while MDM2 overexpression upregulated them. We further revealed that the regulation of TAp73 transcriptional activity occurs as a synergistic effect of MDM2 and E2F1, most probably through their physical interaction in the nuclei. Furthermore, we also suggested that MDM2 might be involved in DNA damage-induced TAp73 transcriptional activity. Finally, we elucidated that MDM2-silencing reduced the proliferation rate of colon carcinoma cells regardless of the p53 status. Our data show a synergistic effect of MDM2 and E2F1 on TAp73 transcriptional activity, suggesting a novel regulation pathway of TAp73

  2. Ionic liquid activated Bacillus subtilis lipase A variants through cooperative surface substitutions.

    Zhao, Jing; Jia, Ning; Jaeger, Karl-Erich; Bocola, Marco; Schwaneberg, Ulrich

    2015-10-01

    The interest in performing enzyme-catalyzed reactions in amphiphilic systems, e.g., imidazolium-based ionic liquids (ILs) or surfactants, has been increased over the past decades. Directed protein evolution has been successful in tailoring enzymes for desired properties. Herein, nine IL-resistant Bacillus subtilis lipase A variants, particularly an IL-activated variant M1 (M134N/N138S/L140S), were identified by directed evolution. For instance, variant M2 (M134R/L140S) showed almost doubled specific activity (16.9 vs. 9.4 U/mg) and resistance (233% vs. 111%) at 9 vol% 1-butyl-3-methylimidazolium trifluoromethanesulfonate ([C4 mim][TfO]) compared with wild-type. The specific activities and resistance of purified individual single and double variants have been studied in five different IL-aqueous mixtures. The re-activation of lipase variant M1 (not wild-type) at high IL concentration was attributed to the cooperative effect of three surface substitutions (M134N, N138S, L140S) near the substrate-binding cleft. The presence of IL/substrate clusters under assay conditions was likely related to the re-activation effect. This study provides first example of IL-activated lipase variant generated by protein engineering, and helps to better understand the protein-IL interaction. PMID:25899108

  3. Union Activities to promote cooperative activities at enterprise level: workplace assesment

    Jensen, Per Langå; Høy, Jette

    1996-01-01

    An analysis of the information activities on workplace assessment from a major Danish confederation......An analysis of the information activities on workplace assessment from a major Danish confederation...

  4. Epicutaneous Allergic Sensitization by Cooperation between Allergen Protease Activity and Mechanical Skin Barrier Damage in Mice.

    Shimura, Sakiko; Takai, Toshiro; Iida, Hideo; Maruyama, Natsuko; Ochi, Hirono; Kamijo, Seiji; Nishioka, Izumi; Hara, Mutsuko; Matsuda, Akira; Saito, Hirohisa; Nakae, Susumu; Ogawa, Hideoki; Okumura, Ko; Ikeda, Shigaku

    2016-07-01

    Allergen sources such as mites, insects, fungi, and pollen contain proteases. Airway exposure to proteases induces allergic airway inflammation and IgE/IgG1 responses via IL-33-dependent mechanisms in mice. We examined the epicutaneous sensitization of mice to a model protease allergen, papain; the effects of tape stripping, which induces epidermal barrier dysfunction; and the atopic march upon a subsequent airway challenge. Papain painting on ear skin and tape stripping cooperatively promoted dermatitis, the skin gene expression of proinflammatory cytokines and growth factors, up-regulation of serum total IgE, and papain-specific IgE/IgG1 induction. Epicutaneous sensitization induced T helper (Th) 2 cells and Th17 differentiation in draining lymph nodes. Ovalbumin and protease inhibitor-treated papain induced no or weak responses, whereas the co-administration of ovalbumin and papain promoted ovalbumin-specific IgE/IgG1 induction. Wild-type and IL-33-deficient mice showed similar responses in the epicutaneous sensitization phase. The subsequent airway papain challenge induced airway eosinophilia and maintained high papain-specific IgE levels in an IL-33-dependent manner. These results suggest that allergen source-derived protease activity and mechanical barrier damage such as that caused by scratching cooperatively promote epicutaneous sensitization and skin inflammation and that IL-33 is dispensable for epicutaneous sensitization but is crucial in the atopic march upon a subsequent airway low-dose encounter with protease allergens. PMID:26987428

  5. ESA activities on satellite laser ranging to non-cooperative objects

    Flohrer, Tim; Krag, Holger; Funke, Quirin; Jilete, Beatriz; Mancas, Alexandru

    2016-07-01

    Satellite laser ranging (SLR) to non-cooperative objects is an emerging technology that can contribute significantly to operational, modelling and mitigation needs set by the space debris population. ESA is conducting various research and development activities in SLR to non-cooperative objects. ESA's Space Situational Awareness (SSA) program supports specific activities in the Space Surveillance and Tracking (SST) segment. Research and development activities with operational aspects are run by ESA's Space Debris Office. At ESA SSA/SST comprises detecting, cataloguing and predicting the objects orbiting the Earth, and the derived applications. SST aims at facilitating research and development of sensor and data processing technologies and of related common components while staying complementary with, and in support of, national and multi-national European initiatives. SST promotes standardisation and interoperability of the technology developments. For SLR these goals are implemented through researching, developing, and deploying an expert centre. This centre shall coordinate the contribution of system-external loosely connected SLR sensors, and shall provide back calibration and expert evaluation support to the sensors. The Space Debris Office at ESA is responsible for all aspects related to space debris in the Agency. It is in charge of providing operational support to ESA and third party missions. Currently, the office studies the potential benefits of laser ranging to space debris objects to resolve close approaches to active satellites, to improve re-entry predictions of time and locations, and the more general SLR support during contingency situations. The office studies the determination of attitude and attitude motion of uncooperative objects with special focus on the combination of SLR, light-curve, and radar imaging data. Generating sufficiently precise information to allow for the acquisition of debris objects by a SLR sensor in a stare

  6. Activities and cooperation opportunities at Cekmece Nuclear Research and Training Center

    Turkey's familiarization with nuclear energy began in July 1955, when it signed a bilateral agreement with the USA to cooperate in the 'peaceful uses of nuclear energy'. In 1956, the Turkish Atomic Energy Commission (TAEK) was created. Cekmece Nuclear Research and Training Center (CNAEM) was formally established in 1962. Turkey's first research reactor, a pool-type 1 MW reactor at CNAEM site, known as TR-1, went critical in 1962 and was shut down in September 1977. Strong collaborations with national and international organizations have been achieved for the promotion of the peaceful uses of nuclear energy and its applications in Turkey. Meanwhile the TR-2 reactor (5 MW) was commissioned in 1984 in order to meet the increasing demand of radioisotopes.CNAEM as a subsidiary of TAEK is charged to perform R and D activities on whole area of nuclear science and technology, such as research reactor, nuclear safety, nuclear fuel technology and fuel analysis codes, nuclear materials, NDT, nuclear electronics, accelerator, radiobiology, cytogenetics (bio dosimetry), radioecology, marine radioactivity, radiation safety, dosimetry, radioactive waste management, calibration of nuclear instruments, environmental monitoring. Possible cooperation fields between CNAEM and other institutions are as follows: measurements of radioactivity in the environment, radioecological studies of radioactivity levels in environmental samples, indoor radon measurements, development and production of radiopharmaceuticals, radiation cytogenetics (bio dosimetry), training in NDT, certification of industrial workers who use non-destructive testing devices, production of UO2 and (U,Th)O2 based fuel material, development and construction of radiation measurement instrument, analysis of all kind of uranium and thorium, training on processing and storage of low level radioactive waste

  7. Activities and cooperation opportunities at Cekmece nuclear research and training center

    Full text: Turkey's familiarization with nuclear energy began in July 1955, when it signed a bilateral agreement with the USA to cooperate in the peaceful uses of nuclear energy. In 1956, the Turkish Atomic Energy Commission (TAEK) was created. Cekmece Nuclear Research and Training Center (CNAEM) was formally established in 1962. Turkey's first research reactor, a pool-type 1 MW reactor at CNAEM site, known as TR-1, went critical in 1962 and was shut down in September 1977. Strong collaborations with national and international organizations have been achieved for the promotion of the peaceful uses of nuclear energy and its applications in Turkey. Meanwhile the TR-2 reactor (5 MW) was commissioned in 1984 in order to meet the increasing demand of radioisotopes.CNAEM as a subsidiary of TAEK is charged to perform R and D activities on whole area of nuclear science and technology, such as research reactor, nuclear safety, nuclear fuel technology and fuel analysis codes, nuclear materials, NDT, nuclear electronics, accelerator, radiobiology, cytogenetics (bio dosimetry), radioecology, marine radioactivity, radiation safety, dosimetry, radioactive waste management, calibration of nuclear instruments, environmental monitoring. Possible cooperation fields between CNAEM and other institutions are as follows: measurements of radioactivity in the environment, radioecological studies of radioactivity levels in environmental samples, indoor radon measurements, development and production of radiopharmaceuticals, radiation cytogenetics (bio dosimetry), training in NDT, certification of industrial workers who use non-destructive testing devices, production of UO2 and (U,Th)O2 based fuel material, development and construction of radiation measurement instrument, analysis of all kind of uranium and thorium, training on processing and storage of low level radioactive waste

  8. The Agency's technical co-operation activities in 1985. Report by the Director General

    Although total resources and disbursements were higher in 1985 than in previous years, the growth rates for both declined somewhat. New resources for the Technical Assistance and Co-operation Fund (TACF) increased by 13%, the TACF accounting for over 66% of all technical co-operation resources in 1985. Pledges made towards the 1985 target for voluntary contributions to the TACF came close to 90% of the target. Although a significant loss on exchange had to be absorbed by the Fund, 96.9% of the target was covered thanks to additional income. Although extrabudgetary resources declined in 1985, they still accounted for one fifth of all technical assistance resources. There was a significant increase in in-kind contributions; this was attributable to the support for non-destructive testing training in Latin America given by Canada, which was the second largest donor of in-kind assistance after the United States. UNDP resources rose very slightly. With UNDP's new five-year programming cycle beginning in 1987, there may be further increases if new projects are identified and timely action taken. New information on implementation expressed as net expenditure and net expenditure rates has been introduced in the form of Expenditure Summaries I, II and III, which provide a more precise picture of performance by fund, geographic area, programme component, field of activity and technical Division. Net expenditure against all funds stood at 57.9%. Net expenditure against the TACF was 66.3%. As UNDP resources and funds in trust account for relatively small shares of the programme, their utilization does not influence the overall net expenditure rate significantly. However, the slow utilization of extrabudgetary resources did have an adverse effect on programme performance as a whole. Net expenditures from the TACF continued to increase at a higher rate than resources, so that the unobligated balance declined for the second consecutive year. In the past, the growing unobligated

  9. Cooperative antiproliferative and differentiation-enhancing activity of medicinal plant extracts in acute myeloid leukemia cells.

    Zhamanbayeva, Gulzhan T; Aralbayeva, Araylim N; Murzakhmetova, Maira K; Tuleukhanov, Sultan T; Danilenko, Michael

    2016-08-01

    Acute myeloid leukemia (AML) is an aggressive hematopoietic malignancy with poor prognosis and limited treatment options. Sea buckthorn (Hippophae rhamnoides) berries, dog rose (Rosa canina) rosehips, and garden sage (Salvia officinalis) and oregano (Origanum vulgare) aerial parts are widely used in traditional medicine and exhibit antitumor effects in preclinical models. However, these plants remain scarcely tested for antileukemic activity. Here, we show that their water-ethanol leaf extracts reduced the growth and viability of AML cells and, at non-cytotoxic doses, potentiated cell differentiation induced by a low concentration of 1α,25-dihydroxyvitamin D3, the hormonal form of vitamin D, in a cell type-dependent manner. The latter effect was accompanied by upregulation of the vitamin D receptor protein components and its transcriptional activity. Furthermore, at minimally effective doses the extracts cooperated with one another to produce marked cytostatic effects associated with a partial S-phase arrest and a modest induction of apoptosis. In contrast, these combinations only slightly affected the growth and viability of proliferating normal human peripheral blood mononuclear cells. In addition, the extracts strongly inhibited microsomal lipid peroxidation and protected normal erythrocytes against hypoosmotic shock. Our results suggest that further exploration of the enhanced antileukemic effects of the combinations tested here may lead to the development of alternative therapeutic and preventive approaches against AML. PMID:27470342

  10. Data Information for Global Change Studies: NASA's Distributed Active Archive Centers and Cooperating Data Centers

    2000-01-01

    The Earth Observing System (EOS) is an integral part of the National Aeronautics and Space Administration's (NASA's) Earth Science Enterprise (ESE). ESE is a long-term global change research program designed to improve our understanding of the Earth's interrelated processes involving the atmosphere, oceans, land surfaces, and polar regions. Data from EOS instruments and other Earth science measurement systems are useful in understanding the causes and processes of global climate change and the consequences of human activities. The EOS Data and Information System (EOSDIS) provides a structure for data management and user services for products derived from EOS satellite instruments and other NASA Earth science data. Within the EOSDIS framework, the Distributed Active Archive Centers (DAACs) have been established to provide expertise in one or more Earth science disciplines. The DAACs and cooperating data centers provide data and information services to support the global change research community. Much of the development of the DAACs has been in anticipation of the enormous amount of data expected from EOS instruments to be launched within the next two decades. Terra, the EOS flagship launched in December 1999, is the first of a series of EOS satellites to carry several instruments with multispectral capabilities. Some data products from these instruments are now available from several of the DAACs. These and other data products can be ordered through the EOS Data Gateway (EDG) and DAAC-specific online ordering systems.

  11. Review of occupational safety and health activities in Southern Africa funded under the DANIDA/ILO framework agreement on technical cooperation

    Hasle, Peter; Jørgensen, Claus

    2003-01-01

    A review of occupational safety and health activities in Southern Africa (SADC region) which have been funded under the DANIDA/ILO framework agreement on technical cooperation.......A review of occupational safety and health activities in Southern Africa (SADC region) which have been funded under the DANIDA/ILO framework agreement on technical cooperation....

  12. Cooperation of Doxycycline with Phytochemicals and Micronutrients Against Active and Persistent Forms of Borrelia sp.

    Goc, Anna; Niedzwiecki, Alexandra; Rath, Matthias

    2016-01-01

    Phytochemicals and micronutrients represent a growing theme in antimicrobial defense; however, little is known about their anti-borreliae effects of reciprocal cooperation with antibiotics. A better understanding of this aspect could advance our knowledge and help improve the efficacy of current approaches towards Borrelia sp. In this study, phytochemicals and micronutrients such as baicalein, luteolin, 10-HAD, iodine, rosmarinic acid, and monolaurin, as well as, vitamins D3 and C were tested in a combinations with doxycycline for their in vitro effectiveness against vegetative (spirochetes) and latent (rounded bodies, biofilm) forms of Borrelia burgdorferi and Borrelia garinii. Anti-borreliae effects were evaluated according to checkerboard assays and supported by statistical analysis. The results showed that combination of doxycycline with flavones such as baicalein and luteolin exhibited additive effects against all morphological forms of studied Borrelia sp. Doxycycline combined with iodine demonstrated additive effects against spirochetes and biofilm, whereas with fatty acids such as monolaurin and 10-HAD it produced FICIs of indifference. Additive anti-spirochetal effects were also observed when doxycycline was used with rosmarinic acid and both vitamins D3 and C. Antagonism was not observed in any of the cases. This data revealed the intrinsic anti-borreliae activity of doxycycline with tested phytochemicals and micronutrients indicating that their addition may enhance efficacy of this antibiotic in combating Borrelia sp. Especially the addition of flavones balcalein and luteolin to a doxycycline regimen could be explored further in defining more effective treatments against these bacteria. PMID:27570483

  13. Radiation protection activities under a Regional Co-operative Agreement (RCA)

    The current status of a Regional Co-operative Agreement (RCA) project on 'strengthening of radiation protection' is described. All the RCA Member States, i.e. Australia, Bangladesh, China, India, Indonesia, Japan, the Republic of Korea, Malaysia, Pakistan, the Philippines, Singapore, Sri Lanka, Thailand and Viet Nam are participating in the project and providing the financial and human resources necessary for its implementation. The objective of the project is to strengthen radiation protection capabilities in the RCA region with emphasis on the establishment and development of the infrastructure, in particular, manpower development in dosimetry, dose and risk assessment, protection practices, emergency countermeasures, regulatory provisions, and educational and training systems. The activities include practical training, the acquisition of fundamental knowledge and techniques; workshop and study tours at an advanced level; a co-ordinated research programme to obtain data essential for radiation protection measures in the region; assignment of experts to address specific problems; provision of long term fellowships to supplement short term training; provision of instruments and equipment; participation in the radiation protection advisory team (RAPAT) programme of the IAEA; and periodic evaluation of the project. These activities are applied in a concerted way to industrial applications, including nuclear energy and medical and biological applications. In the field of industrial applications, two training courses and two workshops including study tours were implemented in 1988 and 1989, and one training course and two workshops are envisaged for 1990. In the medical and biological field, efforts have been concentrated on the co-ordinated research programme which aims at compiling essential data of the region for setting Reference Asian Man. 1 tab

  14. THE SOCIAL ORIENTATION OF THE ACTIVITY OF THE LABOUR WORKING COOPERATIVES FOR DISABLED PEOPLE IN BULGARIA

    Albena MITEVA; Zornitsa STOYANOVA

    2014-01-01

    Bulgaria's membership in the European Union defines the orientation of our country in line with the key strategic priorities of Europe 2020, which aims to achieve smart, sustainable and inclusive growth. The role of the cooperative system becomes especially important at this time when the EU itself is constructed as a union of equal socially oriented states. In the paper is depicted the role of the labour working producer cooperatives for disabled people as one of the main actors of the socia...

  15. Local climate activities in co-operation between municipality, civil society and science shop

    Jørgensen, Michael Søgaard

    2009-01-01

    The Science Shop at DTU co-operates with the local municipal administration and the local branch of an environmental NGO about climate change. The co-operation was initiated by a proposal to the Science Shop from the municipal administration. Since the Science Shop requests civil society involvement in projects it was proposed to involve the local branch of the environmental NGO. The starting point was topics developed by the administration and the NGO together and announced to students as pa...

  16. RCA and its regional office for cooperative activities in the applications of nuclear techniques in Asia and the Pacific

    The Regional Cooperative Agreement for Research, Development and Training Related to Nuclear Science and Technology (RCA) is an intergovernmental agreement among 17 Member States of the International Atomic Energy Agency (IAEA), in South Asia, South East Asia, Far East and the Pacific, established for promoting regional cooperation in the peaceful uses of nuclear science and technology. Established in 1972, the RCA is a unique development within the technical cooperation framework coordinated by IAEA is support of the regional cooperation in the applications of nuclear technology to the benefit of its Member States. It has a well established network of scientists trained in the use of nuclear technologies in the agricultural, medical, industrial, and environmental sectors, with a good potentiality to use its regional technical and scientific resources to contribute to the solution of some of the significant problems in the region. The achievements recorded in the several decades of RCA history cover a wide spectrum of areas and these achievements have been published a Success Stories. Having recognized a need to enhance ownership of the region, the RCA Member States had wished to establish its Regional Office (RCARO). The Regional Office which is hosted by the Government of Republic of Korea was established in 2002. Located in Daejeon, the RCARO has been active in its endeavors toward increasing visibility of the RCA and establishing cooperative partnership between RCA and other international organizations. The RCARO has also played a key role in successfully implementing an RCA Project on Post-Tsunami Environment Impact Assessment in partnership with UNDP (Republic of Korea) with the participation of 14 RCA Member States. A number of projects for capacity building in the region are also being implemented by RCARO, mostly by providing training opportunities for young professionals in the region. The RCA community welcomes any contacts from potential end-users or

  17. Cooperative phenomena in binding and activation of Bordetella pertussis adenylate cyclase by calmodulin.

    Bouhss, A; Krin, E; Munier, H; Gilles, A M; Danchin, A; Glaser, P; Bârzu, O

    1993-01-25

    The catalytic domain of Bordetella pertussis adenylate cyclase located within the first 400 amino acids of the protein can be cleaved by trypsin in two subdomains (T25 and T18) corresponding to ATP-(T25) and calmodulin (CaM)-(T18) binding sites. Reassociation of subdomains by CaM is a cooperative process, which is a unique case among CaM-activated enzymes. To understand better the molecular basis of this phenomenon, we used several approaches such as partial deletions of the adenylate cyclase gene, isolation of peptides of various size, and site-directed mutagenesis experiments. We found that a stretch of 72 amino acid residues overlapping the carboxyl terminus of T25 and the amino terminus of T18 accounts for 90% of the binding energy of adenylate cyclase-CaM complex. The hydrophobic "side" of the helical region situated around Trp242 plays a major role in the interaction of adenylate cyclase with CaM, whereas basic residues that alternate with acidic residues in bacterial enzyme play a much less important role. The amino-terminal half of the catalytic domain of adenylate cyclase contributes only 10% to the binding energy of CaM, whereas the last 130 amino acid residues are not at all involved in binding. However, these segments of adenylate cyclase might affect protein/protein interaction and catalysis by propagating conformational changes to the CaM-binding sequence which is located in the middle of the catalytic domain of bacterial enzyme. PMID:8420945

  18. Conditional cooperativity in toxin-antitoxin regulation prevents random toxin activation and promotes fast translational recovery.

    Cataudella, Ilaria; Trusina, Ala; Sneppen, Kim; Gerdes, Kenn; Mitarai, Namiko

    2012-08-01

    Many toxin-antitoxin (TA) loci are known to strongly repress their own transcription. This auto-inhibition is often called 'conditional cooperativity' as it relies on cooperative binding of TA complexes to operator DNA that occurs only when toxins are in a proper stoichiometric relationship with antitoxins. There has recently been an explosion of interest in TA systems due to their role in bacterial persistence, however the role of conditional cooperativity is still unclear. We reveal the biological function of conditional cooperativity by constructing a mathematical model of the well studied TA system, relBE of Escherichia coli. We show that the model with the in vivo and in vitro established parameters reproduces experimentally observed response to nutritional stress. We further demonstrate that conditional cooperativity stabilizes the level of antitoxin in rapidly growing cells such that random induction of relBE is minimized. At the same time it enables quick removal of free toxin when the starvation is terminated. PMID:22495927

  19. International Cooperation: IAEA’s Role and Activities in Nuclear Security

    The mandate of the International Atomic Energy Agency (IAEA) in the area of nuclear security has been clearly established. The IAEA’s own legal framework includes the IAEA Statute, resolutions adopted by the IAEA Board of Governors and General Conference, and resolutions adopted by the United Nations Security Council and General Assembly that refer to the IAEA. Provisions in several international conventions adopted under the IAEA’s and other auspices have also contributed to the IAEA’s mandate and functions in the area of nuclear security. The first part of this paper considers in more detail relevant aspects of the international legal framework for nuclear security that support international cooperation assistance and further define the role of the IAEA. The paper also seeks to dispel some common myths that surround international cooperation and assistance in nuclear security and considers future directions for the IAEA in relation to its role in facilitating international cooperation and assistance in nuclear security

  20. Regional cooperation-activities of the working group on waste management

    A Working Group on Waste Management was formally established by the Pacific Basin Nuclear Cooperation Committee at its meeting on November 19, 1986. Co-chairmen are Dr. Kunihiko Uematsu of Japan and the author, Gordon L. Brooks of Canada. Since the Working Group is newly formed, a consensus program has not yet been developed. In lieu of this, the author suggests a series of basic issues and possible areas of future collaboration which could serve as a starting point for the Working Group in developing an appropriate cooperative program. (author)

  1. SPECIFICITY OF SOCIAL COOPERATIVES ACTIVITY AS A SUBJECTS OF SOCIAL ECONOMY

    Danuta Mierzwa

    2014-09-01

    Full Text Available The article shows the role of social enterprises on the labour market, exemplified by social cooperatives. In market economy, basing on experiences of a number of EU states, it is possible to state that there is a reason for existence of that type of enterprises, which can be proved by their continuous development and supporting policy of the European Parliament. These enterprises are often the only chance for marginalized and socially excluded people. The work made use of provisions of the law regarding operation of social cooperatives, different types of elaborations, as well as scientific literature.

  2. An Outline of the Goals, Objectives, and Activities of the Princeton Cooperative School Program.

    Fiori, Clem, Ed.; Thomas, Earl P., Ed.

    The Princeton Cooperative School Program (PCSP), an Upward Bound project at Princeton University, was initiated in 1964 and continued until October 1976. Program services were directed toward low-income, educationally disadvantaged, high potential adolescents, and the program's goal was to enlarge the pool of qualified, low-income, disadvantaged…

  3. 76 FR 18165 - Request for Public Comments Concerning Regulatory Cooperation Activities That Would Help...

    2011-04-01

    ... Would Help Eliminate or Reduce Unnecessary Regulatory Divergences in North America That Disrupt U.S..., 2011. DATES: The comment period for notice published on March 3, 2011 (76 FR 11760), is extended to....-Canada Regulatory Cooperation Council. The notice published on March 3, 2011 (76 FR 11760)...

  4. A Gender Comparison of the Cooperation of 4-Year-Old Children in Classroom Activity Centers

    Anderson, Genan T.; Hilton, Sterling C.; Wouden-Miller, Melissa

    2003-01-01

    This study examined the proportion of cooperative play in 4-year-old children across centers (housekeeping, block, manipulative, and computer) and gender in a natural classroom setting. Eighty-four white, middle-income children (41 boys and 43 girls, mean age = 55 months) were videotaped during free-play for 30 minutes per day for four weeks in…

  5. “Nihon Koujin Club” and Its Activities with reference to Social Cooperation and Continuing Development of Engineers

    Mori, Kazu-Hiro

    “Nihon Koujin Club” and its activities are reviewed with reference to social cooperation and continuing development of engineers. Nihon Koujin Club was the first Japanese association of working-engineers (“koujin” in Japanese) established in 1920. At one time, more than 5000 engineers from various fields of engineering registered as the member of the club. Nihon-Koujin Club carried out various activities such as examinations to qualify professional engineers, enlightening activities for engineers' ethics and improvement of working conditions and so on. Proposals to governments were sometimes made one of which was that on engineering education. When it started, Nihon Koujin Club had an ambition to exchange information together with international counterparts such as The British Association of Scientific Worker. Unfortunately the direction of the club has deviated from its original purpose due to historical circumstances of nationalism of those days. Nevertheless its activities could be appreciated as an early stage of movement of engineers in Japan. The modern activities related to social cooperation or continuing development of engineers can be traced back to the activities of Nihon Koujin Club.

  6. EL INCUMPLIMIENTO DE PARTICIPAR EN LA ACTIVIDAD EN COOPERATIVAS AGRARIAS / THE FAILURE TO PARTICIPATE IN THE ACTIVITY OF AGRICULTURAL COOPERATIVES

    LUIS PEDRO GALLEGO SEVILLA

    2011-01-01

    Full Text Available La voluntad de contribuir al logro de un proyecto común, la fidelidad a los objetivos colectivos y el propósito de cumplir los compromisos adquiridos deberían ser las motivaciones básicas del socio de una cooperativa. Sin embargo, en demasiadas ocasiones, algunos cooperativistas no aportan a la empresa colectiva las cuantías comprometidas, perjudicando así los intereses de la entidad y del resto de los socios. A pesar de que estos comportamientos suponen una infracción del deber básico de participar en las actividades de la cooperativa, resulta difícil sancionar a los infractores y, todavía más, reparar los perjuicios económicos que ocasionan. Por ello, planteamos aquí la exploración de una vía complementaria a la vía sancionadora prevista en nuestras leyes para combatir los incumplimientos del deber de participar en la actividad típica de la cooperativa, que se conoce como “actividad cooperativizada”. / The basic motivations of the member of a cooperative should be to contribute to the achievement of a common project, loyalty to the collective objectives and purpose of fulfilling their commitments. However, too often, some members do not contribute to the cooperative the amounts committed, harming the interests of the society and the other members. Although this behaviour is a violation of a social obligation to participate in the activities of the cooperative, it is difficult to punish offenders and, even more, to repair the economic damage they cause. This study raises the possibility of a complementary economic method, compatible with the legal system of penalties, to cope with the failure to participate in the activity of cooperative.

  7. International co-operation

    Within the Union Nations (UN) framework, the Slovak Republic participated in following activities on environment protection co-operation: UN European Economic Commission, UN Industrial Development Organization, UN Development Programme, UN Human Habitat Organization, UN Environment Programme, and UN Commission on Sustainable Development. Relevant activities of the Slovak Republic in these co-operations as well as in European Union and OECD activities are reviewed. International conventions and other forms of multilateral co-operation, bilateral co-operation, and international programmes and projects in which the Slovak Republic took participate are presented

  8. An fMRI study of joint action – varying levels of cooperation correlates with activity in sensorimotor control, but not mentalization, networks

    Thierry Chaminade

    2012-06-01

    Full Text Available As social agents, humans continuously interact with with the people around them. Here, motor cooperation was investigated by designing a situation in which pairs of participants, one being scanned with fMRI, controlled jointly a visually presented object with joystick movements. The object oscillated dynamically along two dimensions, shades of pink and width of gratings, corresponding to the two cardinal directions of joystick movements. While the overall control of each participant on the object was kept constant, the amount of cooperation along the two dimensions varied along four levels, from no (each participant controlled exclusively one dimension to full (each participant controlled half of each dimension cooperation. Increasing cooperation correlated with BOLD signal in the left parietal operculum and anterior cingulate cortex, while decreasing cooperation correlated with activity in the right inferior frontal and superior temporal gyri, in the intraparietal sulci and inferior temporal gyrii bilaterally, and in the dorsomedial prefrontal cortex. As joint control improved with the level of cooperation, we assessed the brain responses correlating with joint performance, and found that activity in most of the areas associated with levels of cooperation also correlated with the joint performance. The only brain area found exclusively in the negative correlation with cooperation was within the posterior region of the rostral medial frontal cortex, involved in the monitoring of action outcome. We therefore propose that this region responds to the predictability of visual feedback given the motor commands, which is maximal when participants do not cooperate as they fully control one dimension. Our results therefore indicate that, in the current experimental paradigm, the level of cooperation affects sensorimotor processing, but not mentalizing. Altogether, humans do not need to have access to others’ intentional states to cooperate on a joint

  9. On Cooperation of the Universities of Different Countries with Commercial Enterprises and Legal Aspects of their Joint Innovative Activities

    Anna Anisimova

    2011-12-01

    Full Text Available In this article we compare and make generalizations on experiences involving cooperation between research universities in the USA, Germany, Poland and Russia and commercial enterprises in these countries. We analyze the processes of commercialization of new technologies as a promising tendency in supporting competitiveness for joint scientific and technological output of universities and companies. The experience of different countries and the economic implications for scientific, technical and intellectual advancements is considered here. We also examine the necessity for additional financial and legal regulation of research activities and defense of intellectual property.

  10. OECD/NEA activities to enhance cooperation among technical organizations involved with nuclear safety assessment and research

    The first priority for the member countries of the OECD Nuclear Energy Agency (OECD/NEA) is nuclear safety and regulation. This fact is clearly recognized in the OECD/NEA strategic plan for 2005-2009 and directs the activities of the OECD/NEA's programme of work, in particular, those carried out by the safety committees - the Committee on the Safety of Nuclear Installations (CSNI) and the Committee on Nuclear Regulatory Activities (CNRA). To accomplish these objectives, the CSNI is organized into six permanent working groups, each covering a different set of technical disciplines. The CSNI has produced numerous state of the art reports (SOARs) or international standard problems (ISPs), which have been key contributors to national safety assessment practices. The CSNI is also responsible for organizing and monitoring cooperative research projects, which are generally organized to share costs and information on research programmes of common interest to many member countries and/or to ensure that key facilities/programmes related to the nuclear safety infrastructure are maintained. Currently, there are 15 ongoing safety research projects. OECD projects like LOFT (Loss of Fluid Test) and Halden are recognized worldwide. The paper underlines the main findings from past OECD/NEA experience, focusing on specific safety activities and showing the added value provided to member countries. From the OECD/ NEA perspective, any concerted action among technical institutions addressing safety should build on the successful cooperation existing today. (author)

  11. International cooperation for operating safety

    The international-cooperation organization in nuclear safety domain is discussed. The nuclear energy Direction Committee is helped by the Security Committee for Nuclear Power Plants in the cooperation between security organizations of member countries and in the safety and nuclear activity regulations. The importance of the cooperation between experts in human being and engine problems is underlined. The applied methods, exchange activities and activity analysis, and the cooperation of the Nuclear Energy Agency and international organizations is analysed

  12. Multistep Molecular Dynamics Simulations Identify the Highly Cooperative Activity of Melittin in Recognizing and Stabilizing Membrane Pores.

    Sun, Delin; Forsman, Jan; Woodward, Clifford E

    2015-09-01

    The prototypical antimicrobial peptide, melittin, is well-known for its ability to induce pores in zwitterionic model lipid membranes. However, the mechanism by which melittin accomplishes this is not fully understood. We have conducted all-atom and coarse-grained molecular dynamics simulations which suggest that melittin employs a highly cooperative mechanism for the induction of both small and large membrane pores. The process by which this peptide induces membrane pores appears to be driven by its affinity to membrane defects via its N-terminus region. In our simulations, a membrane defect was deliberately created through either lipid flip-flop or the reorientation of one adsorbed melittin peptide. In a cooperative response, other melittin molecules also inserted their N-termini into the created defect, thus lowering the overall free energy. The insertion of these peptide molecules ultimately allowed the defect to develop into a small transmembrane pore, with an estimated diameter of ∼1.5 nm and a lifetime of the order of tens of milliseconds. In the presence of a finite membrane tension, we show that this small pore can act as a nucleation site for the stochastic rupture of the lipid bilayer, so as to create a much larger pore. We found that a threshold membrane tension of 25 mN/m was needed to create a ruptured pore. Furthermore, by actively accumulating at its edge, adsorbed peptides are able to cooperatively stabilize this larger pore. The defect-mediated pore formation mechanism revealed in this work may also apply to other amphipathic membrane-active peptides. PMID:26267389

  13. Knowledge management within the National Commission for Nuclear Activities Control and related support provided by international cooperation

    The National Commission for Nuclear Activities Control (CNCAN) is the Romanian competent authority in the nuclear field having responsibilities for regulation, licensing and control. CNCAN is in the process of recruiting new staff. In order to fill the vacancies, CNCAN will organize additional examination sessions in accordance with the commitments assumed within the Plan of Priority Measures for European Accession January-December 2005. The process for recruitment and staff training is developed in accordance with CNCAN internal rules approved by the Government. Taking into account priorities and opportunities, training is developed through self-study, as well as under the in-house training programme and/or under the international cooperation programmes. In this respect, CNCAN benefited from technical assistance from the IAEA and European Commission, as well as under bilateral cooperation with institutions from other countries developing activities in the field. CNCAN has already taken some steps towards introducing knowledge management. A knowledge preservation policy is in place, based on several measures including unlimited access to information provided through the Internet/intranet, access to dedicated publications, annual training programmes addressing the needs of the employees and the organization, knowledge dissemination sessions and increasing staff motivation. (author)

  14. Cross-sector cooperation in health-enhancing physical activity policymaking

    Hämäläinen, Riitta-Maija; Aro, Arja R; Lau, Cathrine Juel;

    2016-01-01

    policies. The main issues of the cross-sector policy process can be divided into stakeholder involvement, governance structures and coordination structures and processes. Stakeholder involvement included citizen hearings and gatherings of stakeholders from various non-governmental organisations and citizen...... groups. Governance structures with policy and political discussions included committees, working groups and consultations for HEPA policymaking. Coordination structures and processes included administrative processes with various stakeholders, such as ministerial departments, research institutes and...... participation with the co-production of goals and sharing of resources between stakeholders, which could, for example, provide mechanisms for collaborative decision-making through citizen hearing. Clearly stated responsibilities, goals, communication, learning and adaptation for cross-sector cooperation improve...

  15. Outlook to nonproliferation activities in the world and cooperation in peaceful uses of nuclear energy among turkish speaking countries

    Full text: Nuclear technology is being widely used in protecting the environment, manufacturing industry, medicine, agriculture, food industry and electricity production. In the world, 438 Nuclear Power Plants are in operation, and 31 are under construction. Nuclear share of total electricity generation have reached to 17 percent. However, 2053 nuclear tests from 1945 to 1999 and 2 atom bombs to Hiroshima and Nagasaki in 1945 have initiated nonproliferation activities aiming to halt the spread of nuclear weapons and to create a climate where cooperation in the peaceful uses of nuclear energy can be fostered. In addition to international efforts for non proliferation of nuclear weapons, great affords were made for disarmament and banning the nuclear tests which damage the environment. Following the 1st Geneva Conference in 1955 for expanding peaceful uses of nuclear energy, Turkey was one of the first countries to start activities in the nuclear field. Turkish Atomic Energy Authority (TAEK) was established in 1956 and Turkey became a member of the International Atomic Energy Agency established in 1957 by the United Nations for spreading the use of nuclear energy to contribute peace, health and prosperity throughout the world, in same year. Turkey is a candidate state to join the European Union and has already signed Custom Union Agreement, also part of the Eurasia Region. So, there are significant developments in the cultural, social, technical, economical and trade relations owing to our common historical and cultural values with the countries in the region and Central Asia. TAEK was established to support, co-ordinate and perform the activities in peaceful uses of nuclear energy and act as a regulatory body and establish cooperation with countries and international organizations. In the late 1990's, TAEK, besides the co operations with various countries, has involved in cooperating with nuclear institutes of Azerbaijan, Kazakhstan, Kyrgyzstan, Uzbekistan and

  16. Genetic dissection of independent and cooperative transcriptional activation by the LysR-type activator ThnR at close divergent promoters.

    Rivas-Marín, Elena; Floriano, Belén; Santero, Eduardo

    2016-01-01

    Regulation of tetralin biodegradation operons is one of the examples of unconventional LysR-type mediated transcriptional regulation. ThnR activates transcription from two divergent and closely located promoters PB and PC. Although ThnR activates each promoter independently, transcription from each one increases when both promoters are together. Mutational analysis of the intergenic region shows that cooperative transcription is achieved through formation of a ThnR complex when bound to its respective sites at each promoter, via formation of a DNA loop. Mutations also defined ThnR contact sites that are important for independent transcriptional activation at each promoter. A mutation at the PB promoter region, which abolishes its independent transcription, does not affect at all PB transcription in the presence of the divergent promoter PC, thus indicating that the complex formed via DNA loop can compensate for the deficiencies in the correct protein-DNA interaction at one of the promoters. Combination of mutations in both promoters identifies a region at PC that is not important for its independent transcription but it is essential for cooperative transcription from both promoters. This work provides new insights into the diversity and complexity of activation mechanisms used by the most abundant type of bacterial transcriptional regulators. PMID:27087658

  17. Overview on technical co-operation activities deployed between Romania and International Atomic Energy Agency

    Romania became a Member State of the IAEA in 1957. From the mid 1960s to the mid 1970s Romania received assistance in the frame of the IAEA Technical Co-operation Program mainly in the following areas: research in nuclear physics, medical issues and some application of radiation and isotopes. In 1976 Romania decided to use CANDU type reactors for its NPPs. The construction of five units (of 660 MWe each) started in 1978 at Cernavoda. The orientation of Romania's Technical Co-operation projects was shifted towards the requirements raised by the national Nuclear Power Program and as such 18 projects of the IAEA and 3 projects of the UN development program (for which IAEA was a executive Agency) have been directly concerned with it. To develop scientific and technological support for nuclear power program a TRIGA 14 MW Materials Testing Reactor was commissioned at Pitesti in 1979. After 1989 the TC program was tailored to assist manpower training in areas related to nuclear power. In the period 1991 - 1995 a total of 33 TC projects were deployed. The largest part of researches were allotted to projects in nuclear engineering and technology field including also safety aspects (41%), followed by nuclear physics research (25%). During 1991 - 1994 Romania received 12% of the total funds allotted for TC program in Europe. In 1995 - 1996 cycle there were 24 on-going TC projects in Romania, implying the total resource allocation of USD 1,27 million. Diverse areas were covered by the program: 6 projects were related to Cernavoda NPP, followed by applications of nuclear techniques in medicine, agriculture and environment. A special attention was given to the following two projects: Industrial Radiation Sterilization and Decommissioning Plan for WWR-S research reactor. In the present cycle the first model project in Romania was started by the Agency based on initially approved financing of USA 1,6 million. The main area covered is still nuclear safety. For 1999 - 2000 biennial

  18. Cooperation between the two heads of smooth muscle myosin is essential for full activation of the motor function by phosphorylation.

    Ma, Rong-Na; Mabuchi, Katsuhide; Li, Jing; Lu, Zekuan; Wang, Chih-Lueh Albert; Li, Xiang-dong

    2013-09-10

    The motor function of smooth muscle myosin (SmM) is regulated by phosphorylation of the regulatory light chain (RLC) bound to the neck region of the SmM heavy chain. It is generally accepted that unphosphorylated RLC induces interactions between the two heads and between the head and the tail, thus inhibiting the motor activity of SmM, whereas phosphorylation of RLC interrupts those interactions, thus reversing the inhibition and restoring the motor activity to the maximal value. One assumption of this model is that single-headed SmM is fully active regardless of phosphorylation. To re-evaluate this model, we produced a number of SmM constructs with coiled coils of various lengths and examined their structure and regulation. With these constructs we identified the segment in the coiled-coil key for the formation of a stable double-headed structure. In agreement with the current model, we found that the actin-activated ATPase activity of unphosphorylated SmM increased with shortening of the coiled-coil. However, contrary to the current model, we found that the actin-activated ATPase activity of phosphorylated SmM decreased with shortening coiled-coil and only the stable double-headed SmM was fully activated by phosphorylation. These results indicate that single-headed SmM is neither fully active nor fully inhibited. Based on our findings, we propose that cooperation between the two heads is essential, not only for the inhibition of unphosphorylated SmM, but also for the activation of phosphorylated SmM. PMID:23947723

  19. Hepatitis C virus NS5A mediated STAT3 activation requires co-operation of Jak1 kinase

    Hepatitis C virus (HCV) is a major etiologic agent for chronic hepatitis worldwide and often leads to cirrhosis and hepatocellular carcinoma. However, the mechanism for development of chronic hepatitis or hepatocarcinogenesis by HCV remains unclear. Signal transducers and activators of transcription (STATs) family proteins function as the downstream effectors of cytokine signaling and play a critical role in cell growth regulation. In many cancers including liver, STAT3 is often constitutively activated, although the mechanism of persistent activation of STAT3 is unknown. The nonstructural protein 5A (NS5A) encoded from the HCV genome has shown cell growth regulatory properties. In this study, we have observed that HCV NS5A activates STAT3 phosphorylation, which in turn translocates into the nucleus. In vivo activation of STAT3 was also observed in the liver of transgenic mice expressing HCV NS5A. Introduction of NS5A in hepatoma cells modulated STAT3 downstream molecules Bcl-xL and p21 expression. To determine if STAT3 activation by NS5A could induce STAT3 mediated gene expression, a luciferase reporter construct based on a synthetic promoter was used to transfect hepatoma cells. Activation of endogenous cellular STAT3 by HCV NS5A induced luciferase gene expression through STAT3 specific binding elements. Our subsequent studies suggested that NS5A forms a complex with Jak1 and recruits STAT3 for activation. Taken together, our results suggested that NS5A activates STAT3 through co-operation of Jak1 kinase and activated STAT3 may contribute to HCV-mediated pathogenesis

  20. Constitutively Active Akt1 Cooperates with KRasG12D to Accelerate In Vivo Pancreatic Tumor Onset and Progression

    Toya M. Albury

    2015-02-01

    Full Text Available BACKGROUND AND AIMS: Pancreatic adenocarcinoma is a deadly disease characterized by metastatic progression and resistance to conventional therapeutics. Mutation of KRAS is the most frequent early event in pancreatic tumor progression. AKT isoforms are frequently activated in pancreatic cancer, and reports have implicated hyperactivation of AKT1, as well as AKT2, in pancreatic tumor formation. The objective here is to delineate the role of AKT in facilitating in vivo pancreatic tumor progression in the context of KRAS mutation and predisposition to pancreatic cancer. METHODS: Mice with Akt1 and KRas mutant alleles expressed using the pancreas Pdx promoter were mated to characterize the incidence and frequency of histologic and genetic alterations known to occur commonly in human pancreatic ductal adenocarcinoma. RESULTS: Active Akt1 (Akt1Myr, containing a myristoylation sequence cooperated with active mutant KRasG12D to accelerate pancreatic carcinoma onset and progression and increase phosphorylation of downstream effectors in the Akt pathway. Mucin and smooth muscle actin expression was found in and around pancreatic intraepithelial neoplasms (PanINs, and accelerated time to metastasis was found in Akt1Myr/KRasG12D mice. CONCLUSIONS: In contrast to prior reports of pancreatic KRas mutant mice mated with mice deficient for various tumor suppressor genes, which resulted in aggressive disease within a few months of age, Akt1Myr/KRasG12D mice enabled the study of PanINs and spontaneous pancreatic transformation more characteristic of human pancreatic progression in elderly individuals. The Akt1Myr/KRasG12D model holds promise for delineating the tumor biology and biomarkers critical for understanding their cooperation in cancer oncogenesis and future targeting in therapeutic strategies.

  1. Cooperative Learning

    桑莹莹

    2015-01-01

    This paper is about the cooperative learning as a teaching method in a second language learning class. It mainly talks about the background, foundation, features, definitions, components, goals, advantages and disadvantages of cooperative learning. And as the encounter of the disadvantages in cooperative learning, this paper also proposes some strategies.

  2. City centres as places for strategic cooperation through active city management - the significance of trade entities

    Branka, Sebastian; Coca-Stefaniak, Andres; Plichta, Jaroslaw

    2016-01-01

    This paper posits that the contemporary city should be viewed as a common space that needs the effort of many various stakeholders in order to satisfy the diverse (and changing) needs of its stakeholders. Yet, achieving this effectively requires active management and coordination of a range of activities. This paper discusses three examples of recent activities in Cracow (Poland) that reflect strategic approach. The first of these case studies focuses on identifying the factors encouraging st...

  3. Fostering Multi-Lateral Cooperation Between The Governments Of Dominican Republic, Colombia, And The United States To Enhance The Protection Of High-Activity Radioactive Sources

    The Global Threat Reduction Initiative (GTRI) reduces and protects vulnerable nuclear and radiological material located at civilian sites worldwide from sabotage, theft or diversion. The GTRI has worked successfully with foreign countries to remove and protect nuclear and radioactive materials including high-activity sources used in medical, commercial, and research applications. There are many barriers to successful bilateral cooperation that must be overcome including language, preconceived perceptions, long distances, and different views on the threat and protection requirements. Successful cooperation is often based on relationships and building trusting relationships takes time. In the case of Dominican Republic, the GTRI first received contact in 2008 from the Government of Dominican Republic. They requested cooperation that was similar to the tri-partite cooperation between Colombia, Mexico and the United States. Throughout the region it was widely known that the GTRI's cooperation with the Government of Colombia was a resounding success resulting in the securing of forty sites; the consolidation of numerous disused/orphan sources at a secure national storage facility; and, the development of a comprehensive approach to security including, inter alia, training and sustainability. The Government of Colombia also showcased this comprehensive approach to thirteen Central American and Caribbean countries at a GTRI regional security conference held in Panama in October 2004. In 2007, Colombia was an integral component of GTRI multi-lateral cooperation initiation in Mexico. As a result, twenty two of Mexico's largest radioactive sites have been upgraded in the past eighteen months. These two endeavors served as catalysts for cooperation opportunities in the Dominican Republic. Representatives from the Colombian government were aware of GTRI's interest in initiating cooperation with the Government of Dominican Republic and to facilitate this cooperation, they

  4. FOSTERING MULTI-LATERAL COOPERATION BETWEEN THE GOVERNMENTS OF DOMINICAN REPUBLIC, COLOMBIA, AND THE UNITED STATES TO ENHANCE THE PROTECTION OF HIGH-ACTIVITY RADIOACTIVE SOURCES

    Butler, Nicholas; McCaw, Erica E.; Wright, Kyle A.; Medina, Maximo

    2009-10-06

    The Global Threat Reduction Initiative (GTRI) reduces and protects vulnerable nuclear and radiological material located at civilian sites worldwide from sabotage, theft or diversion. The GTRI has worked successfully with foreign countries to remove and protect nuclear and radioactive materials including high-activity sources used in medical, commercial, and research applications. There are many barriers to successful bilateral cooperation that must be overcome including language, preconceived perceptions, long distances, and different views on the threat and protection requirements. Successful cooperation is often based on relationships and building trusting relationships takes time. In the case of Dominican Republic, the GTRI first received contact in 2008 from the Government of Dominican Republic. They requested cooperation that was similar to the tri-partite cooperation between Colombia, Mexico and the United States. Throughout the region it was widely known that the GTRI’s cooperation with the Government of Colombia was a resounding success resulting in the securing of forty sites; the consolidation of numerous disused/orphan sources at a secure national storage facility; and, the development of a comprehensive approach to security including, inter alia, training and sustainability. The Government of Colombia also showcased this comprehensive approach to thirteen Central American and Caribbean countries at a GTRI regional security conference held in Panama in October 2004. In 2007, Colombia was an integral component of GTRI multi-lateral cooperation initiation in Mexico. As a result, twenty two of Mexico’s largest radioactive sites have been upgraded in the past eighteen months. These two endeavors served as catalysts for cooperation opportunities in the Dominican Republic. Representatives from the Colombian government were aware of GTRI’s interest in initiating cooperation with the Government of Dominican Republic and to facilitate this cooperation, they

  5. Metal-ligand cooperation in H2 activation with iron complexes bearing hemilabile bis(diphenylphosphino)amine ligands.

    Frank, Nicolas; Hanau, Katharina; Langer, Robert

    2014-10-20

    The octahedral transition-metal complex [(dppa)Fe(Ph2P-N-PPh2)2] (1) [dppa = bis(diphenylphosphino)amine] with homofunctional bidentate ligands is described. The ligand exhibits hemilability due to its small bite angle and the steric repulsion of the coordinated donor groups. As the {Ph2P-N-PPh2}(-) ligand can act as an internal base, heterolytic cleavage of dihydrogen by complex 1 leads to the formation of the hydride complex [(dppa)(Ph2P-N-PPh2)Fe(H)(κ(1)-Ph2P-NH-PPh2)2] (2), representing an example of cooperative bond activation with a homofunctional hemilabile ligand. This study demonstrates that hemilability of homofunctionalized ligands can be affected by careful adjustment of geometric parameters. PMID:25290535

  6. IAEA Technical Co-operation activities: Asia and the Pacific. Workshop on training nuclear laboratory technicians

    The workshop was held to exchange information on existing facilities and programmes in Asia and the Pacific for training nuclear laboratory technicians, to identify future training needs and to assess the need for IAEA's involvement in this field. As the participants outlined the requirements for nuclear laboratory technician training and the facilities available in their respective countries, it became evident that, in addition to the training of radioisotope laboratory technicians, they also wished to review the need for technician training for the operation of nuclear power plants and industrial application of atomic energy. The terms of reference of the workshop were extended accordingly. The opening address by Chang Suk Lee, the Korean Vice Minister of Science and Technology, noted the valuable contribution to quality control and other industrial uses that nuclear techniques have made in his country. He also reviewed the application of nuclear techniques in Korean agriculture and medicine. The participants explored various forms of co-operation that could be established between countries of the region. Exchange programmes, not only for students but also for expert teachers, and the exchange or loan of equipment were suggested. It was felt that some generalized training courses could be organized on a regional basis, and two countries advocated the setting up of a regional training centre. One suggestion was to arrange regional training courses in special fields that would move from one country to another. The need was felt for periodic regional meetings on training methods, course content and other questions relating to training of laboratory technicians. The IAEA was requested to act as a clearinghouse for information on available training facilities in the region and to advise on the curricula for technician training courses. The Agency was also asked to organize short courses for the training of instructors of technicians in the various fields of atomic

  7. Candies to Dye For: Cooperative, Open-Ended Student Activities To Promote Understanding of Electrophoretic Fractionation.

    Emry, Randall; Curtright, Robert D.; Wright, Jonathan; Markwell, John

    2000-01-01

    Introduces electrophoresis activities developed for chemistry and biology courses in which students identify the food, drug, and cosmetic identity of the food dyes used in the coating of candies. (YDS)

  8. Different Head Environments in Tarantula Thick Filaments Support a Cooperative Activation Process

    Sulbarán, Guidenn; Biasutto, Antonio; Alamo, Lorenzo; Riggs, Claire; Pinto, Antonio; Méndez, Franklin; Craig, Roger; Padrón, Raúl

    2013-01-01

    Myosin filaments from many muscles are activated by phosphorylation of their regulatory light chains (RLCs). Structural analysis of relaxed tarantula thick filaments shows that the RLCs of the interacting free and blocked myosin heads are in different environments. This and other data suggested a phosphorylation mechanism in which Ser-35 of the free head is exposed and constitutively phosphorylated by protein kinase C, whereas the blocked head is hidden and unphosphorylated; on activation, my...

  9. Complementarities between organizational changes, R&D activity and technological cooperation for the French manufacturing firms

    Hajjem, Olfa; Ayadi, Mohamed; Pierre GARROUSTE

    2011-01-01

    This article analyzes the determinants of the French companies’ innovation activity while highlighting the importance and the complementarities of the organizational and technological practices’impact. Our results suggest on one hand, that the product or process innovation is determined by the internal and external attributes of the company (size, demand pull and technological class). On the other hand, the complementarities tests between the technological (R&D activity and ...

  10. FOSTERING MULTI-LATERAL COOPERATION BETWEEN THE GOVERNMENTS OF MEXICO, COLOMBIA, AND THE UNITED STATES TO ENHANCE THE PROTECTION OF HIGH-ACTIVITY RADIOACTIVE SOURCES

    Butler, Nicholas; Watson, Erica E.; Wright, Kyle A.

    2009-10-07

    The Global Threat Reduction Initiative (GTRI) reduces and protects vulnerable nuclear and radiological material located at civilian sites worldwide from sabotage, theft or diversion. The GTRI program has worked successfully with foreign countries to remove and protect nuclear and radioactive materials including high-activity sources used in medical, commercial, and research applications. There are many barriers to successful bilateral cooperation that must be overcome including language, preconceived perceptions, long distances, and different views on the threat and protection requirements. Successful cooperation is often based on relationships and building trusting relationships takes time. In the case of Mexico, GTRI first made contact in 2005. The project then lost momentum and stalled. At the same time, GTRI’s cooperation with the Republic of Colombia was a resounding success resulting in the securing of forty sites; the consolidation of numerous disused/orphan sources at a secure national storage facility; and, the development of a comprehensive approach to security including, inter alia, training and sustainability. The government of Colombia also showcased this comprehensive approach to thirteen Central American and Caribbean countries at a GTRI regional security conference held in Panama in October 2004. Representatives from the Colombian government were aware of GTRI’s interest in initiating cooperation with the Government of Mexico and to facilitate this cooperation, they offered to invite their Mexican counterparts to Colombia to observe its successful cooperation with GTRI. Shortly after that visit, the Government of Mexico agreed to move forward and requested that the cooperative efforts in Mexico be performed in a tripartite manner, leveraging the skills, experience, and resources of the Colombians. As a result, 22 of Mexico’s largest radioactive sites have had security upgrades in place within 18 months of cooperation.

  11. Fostering Multi-Lateral Cooperation Between The Governments Of Mexico, Colombia, And The United States To Enhance The Protection Of High-Activity Radioactive Sources

    The Global Threat Reduction Initiative (GTRI) reduces and protects vulnerable nuclear and radiological material located at civilian sites worldwide from sabotage, theft or diversion. The GTRI program has worked successfully with foreign countries to remove and protect nuclear and radioactive materials including high-activity sources used in medical, commercial, and research applications. There are many barriers to successful bilateral cooperation that must be overcome including language, preconceived perceptions, long distances, and different views on the threat and protection requirements. Successful cooperation is often based on relationships and building trusting relationships takes time. In the case of Mexico, GTRI first made contact in 2005. The project then lost momentum and stalled. At the same time, GTRI's cooperation with the Republic of Colombia was a resounding success resulting in the securing of forty sites; the consolidation of numerous disused/orphan sources at a secure national storage facility; and, the development of a comprehensive approach to security including, inter alia, training and sustainability. The government of Colombia also showcased this comprehensive approach to thirteen Central American and Caribbean countries at a GTRI regional security conference held in Panama in October 2004. Representatives from the Colombian government were aware of GTRI's interest in initiating cooperation with the Government of Mexico and to facilitate this cooperation, they offered to invite their Mexican counterparts to Colombia to observe its successful cooperation with GTRI. Shortly after that visit, the Government of Mexico agreed to move forward and requested that the cooperative efforts in Mexico be performed in a tripartite manner, leveraging the skills, experience, and resources of the Colombians. As a result, 22 of Mexico's largest radioactive sites have had security upgrades in place within 18 months of cooperation.

  12. Cooperative effects of hepatitis B virus and TNF may play important roles in the activation of metabolic pathways through the activation of NF-κB.

    Wu, Shuang; Kanda, Tatsuo; Nakamoto, Shingo; Jiang, Xia; Nakamura, Masato; Sasaki, Reina; Haga, Yuki; Shirasawa, Hiroshi; Yokosuka, Osamu

    2016-08-01

    Elevated levels of inflammatory cytokines such as tumor necrosis factor-α (TNF-α) and interleukin (IL)-1β are often observed in the sera of hepatitis B virus (HBV)-infected patients. It is well known that these cytokines activate nuclear factor-κB (NF-κB)-signaling, and are associated with endoplasmic reticulum (ER) stress. We investigated whether HBV or HBV X protein (HBx) enhanced the activation of NF-κB in the presence of TNF and/or IL-1β, and their effects on the expression of metabolic pathway‑associated genes. We examined whether HBV or HBx enhanced cytokine-induced activation of NF-κB in hepatocytes, using a reporter assay, in the presence or absence of TNF and/or IL-1β. The expression of insulin-like growth factor binding protein 1 (IGFBP1), one of the NF-κB target genes was also examined. The expression of metabolic pathway-associated genes in HepG2 and HepG2.2.15 cells in the presence or absence of TNF was evaluated by RT-qPCR. Human hepatocytes expressed TNF receptors and IL-1 receptors. NF-κB was activated by cooperation between HBx and TNF in human hepatocytes. We observed IGFBP1 expression in HBV infection and that a number of metabolic pathway-associated genes were upregulated in HepG2.2.15 cells, compared with HepG2 cells with or without TNF treatment. We observed the cooperative effects of HBV and TNF which enhanced the activation of NF-κB as well as upregulated the expression of metabolic pathway-associated genes in hepatocytes. These effects may be important in the development of HBV-associated metabolic syndrome. PMID:27315566

  13. Complex molecular mechanisms cooperate to mediate histone deacetylase inhibitors anti-tumour activity in neuroblastoma cells

    Nardou Katya

    2008-06-01

    Full Text Available Abstract Background Histone deacetylase inhibitors (HDACi are a new class of promising anti-tumour agent inhibiting cell proliferation and survival in tumour cells with very low toxicity toward normal cells. Neuroblastoma (NB is the second most common solid tumour in children still associated with poor outcome in higher stages and, thus NB strongly requires novel treatment modalities. Results We show here that the HDACi Sodium Butyrate (NaB, suberoylanilide hydroxamic acid (SAHA and Trichostatin A (TSA strongly reduce NB cells viability. The anti-tumour activity of these HDACi involved the induction of cell cycle arrest in the G2/M phase, followed by the activation of the intrinsic apoptotic pathway, via the activation of the caspases cascade. Moreover, HDACi mediated the activation of the pro-apoptotic proteins Bid and BimEL and the inactivation of the anti-apoptotic proteins XIAP, Bcl-xL, RIP and survivin, that further enhanced the apoptotic signal. Interestingly, the activity of these apoptosis regulators was modulated by several different mechanisms, either by caspases dependent proteolytic cleavage or by degradation via the proteasome pathway. In addition, HDACi strongly impaired the hypoxia-induced secretion of VEGF by NB cells. Conclusion HDACi are therefore interesting new anti-tumour agents for targeting highly malignant tumours such as NB, as these agents display a strong toxicity toward aggressive NB cells and they may possibly reduce angiogenesis by decreasing VEGF production by NB cells.

  14. Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative trans-activation

    Helin, K; Wu, C L; Fattaey, A R;

    1993-01-01

    hypophosphorylated form of the retinoblastoma protein (pRB). The other protein, murine DP-1, was purified from an E2F DNA-affinity column, and it was subsequently shown to bind the consensus E2F DNA-binding site. To study a possible interaction between E2F-1 and DP-1, we have now isolated a cDNA for the human...... homolog of DP-1. Human DP-1 and E2F-1 associate both in vivo and in vitro, and this interaction leads to enhanced binding to E2F DNA-binding sites. The association of E2F-1 and DP-1 leads to cooperative activation of an E2F-responsive promoter. Finally, we demonstrate that E2F-1 and DP-1 association is...... required for stable interaction with pRB in vivo and that trans-activation by E2F-1/DP-1 heterodimers is inhibited by pRB. We suggest that "E2F" is the activity that is formed when an E2F-1-related protein and a DP-1-related protein dimerize....

  15. Democratic Participation in the Model for Emphasis and Protection of Cooperative Identity and Social-Economic Activity of the Society

    Sevastita GRIGORESCU; Dan CRUCERU

    2013-01-01

    Cooperatives have always acted to allow people to gain access to goods and services without being exploited. This involves doing business in compliance with a set of values based on what we call today sustainable development. By focusing on human needs, cooperatives respond to crises by contemporary sustainable development, delivering a distinct form of common values. Cooperatives seek to optimize the results for all intervenient, without pursuing the maximization of benefits for a single int...

  16. 40 CFR 35.6225 - Activities eligible for funding under Core Program Cooperative Agreements.

    2010-07-01

    ... section: (1) Procedures for emergency response actions and longer-term remediation of environmental and... interaction in CERCLA implementation (including but not limited to general program management and supervision necessary for a recipient to implement CERCLA activities, and interagency coordination on all phases...

  17. Outlook to nonproliferation activities in the world and cooperation in peaceful uses of nuclear energy among Turkey, Caucasus and Central Asia

    Full text: Following the First Geneva Conference in 1955 for expanding peaceful uses of nuclear energy, Turkey was one of the first countries to start activities in the nuclear field. Turkish Atomic Energy Authority (TAEK) was established in 1956 and Turkey became a member of the International Atomic Energy Agency established in 1957. TAEK was established to support, co-ordinate and perform the activities in peaceful uses of nuclear energy and act as a regulatory body and establish cooperation with countries and international organizations. In the late nineteen-ninetieth, TAEK, besides the cooperation with various countries, has involved in cooperating with nuclear institutes of Azerbaijan, Kazakhstan, Kyrgyzstan, Uzbekistan and Turkmenistan for establishment of bilateral and multilateral scientific and technical cooperation in peaceful uses of nuclear energy and signed protocols with Scientific Organisations of Azerbaijan, Kazakhstan, Kyrgyzstan and Uzbekistan. These protocols enable parties to organize joint projects, conferences, seminars, training programs, establish laboratories for the joint studies and make joint efforts to seek support from their governments and international organizations for these activities. Also, an executive committee has been set up with delegates from each organization under TAEK that also provides the secretarial service for organizing the joint activities. Turkey supports the non-proliferation activities that do not prevent the peaceful uses of nuclear energy and in this respect as signed Non-Proliferation Treaty (NPT) and Comprehensive Nuclear Test Ban Treaty (CTBT). Azerbaijan, Kazakhstan, Kyrgyzstan and Uzbekistan have also signed these Treaties following their independence and, except Kyrgyzstan, have become members to IAEA

  18. Cooperative Regulation of the Activity of Factor Xa within Prothrombinase by Discrete Amino Acid Regions from Factor Va Heavy Chain†

    2008-01-01

    The prothrombinase complex catalyzes the activation of prothrombin to α-thrombin. We have repetitively shown that amino acid region 695DYDY698 from the COOH terminus of the heavy chain of factor Va regulates the rate of cleavage of prothrombin at Arg271 by prothrombinase. We have also recently demonstrated that amino acid region 334DY335 is required for the optimal activity of prothrombinase. To assess the effect of these six amino acid residues on cofactor activity, we created recombinant factor Va molecules combining mutations at amino acid regions 334–335 and 695−698 as follows: factor V3K (334DY335 → KF and 695DYDY698 → KFKF), factor VKF/4A (334DY335 → KF and 695DYDY698 → AAAA), and factor V6A (334DY335 → AA and 695DYDY698 → AAAA). The recombinant factor V molecules were expressed and purified to homogeneity. Factor Va3K, factor VaK4/4A, and factor Va6A had reduced affinity for factor Xa, when compared to the affinity of the wild-type molecule (factor VaWt) for the enzyme. Prothrombinase assembled with saturating concentrations of factor Va3K had a 6-fold reduced second-order rate constant for prothrombin activation compared to the value obtained with prothrombinase assembled with factor VaWt, while prothrombinase assembled with saturating concentrations of factor VaKF/4A and factor Va6A had approximately 1.5-fold reduced second-order rate constants. Overall, the data demonstrate that amino acid region 334–335 together with amino acid region 695−698 from factor Va heavy chain are part of a cooperative mechanism within prothrombinase regulating cleavage and activation of prothrombin by factor Xa. PMID:18991406

  19. TFEB and TFE3 cooperate in the regulation of the innate immune response in activated macrophages.

    Pastore, Nunzia; Brady, Owen A; Diab, Heba I; Martina, José A; Sun, Lu; Huynh, Tuong; Lim, Jeong-A; Zare, Hossein; Raben, Nina; Ballabio, Andrea; Puertollano, Rosa

    2016-08-01

    The activation of transcription factors is critical to ensure an effective defense against pathogens. In this study we identify a critical and complementary role of the transcription factors TFEB and TFE3 in innate immune response. By using a combination of chromatin immunoprecipitation, CRISPR-Cas9-mediated genome-editing technology, and in vivo models, we determined that TFEB and TFE3 collaborate with each other in activated macrophages and microglia to promote efficient autophagy induction, increased lysosomal biogenesis, and transcriptional upregulation of numerous proinflammatory cytokines. Furthermore, secretion of key mediators of the inflammatory response (CSF2, IL1B, IL2, and IL27), macrophage differentiation (CSF1), and macrophage infiltration and migration to sites of inflammation (CCL2) was significantly reduced in TFEB and TFE3 deficient cells. These new insights provide us with a deeper understanding of the transcriptional regulation of the innate immune response. PMID:27171064

  20. Rokkasho reprocessing project. From design to the end of active tests: 21 years of fruitful French-Japanese cooperation

    Aoyagi, H.; Fujita, K. [Japan Nuclear Fuel LTD - JNFL (Japan); Dubanet, T.; Griffon, J.P. [AREVA-NC (France); Drain, F.; Bretault, P.; Fagot, L. [AREVA-SGN, 1 Rue des Herons, Montigny le Bretonneux, 78182 (France)

    2009-06-15

    The first Japanese commercial reprocessing plant has successfully completed active test operation of its main process part in October, 2008. The main part of the plant is based on AREVA process used in French reprocessing plants UP3 and UP2-800 at La Hague. The main process choices have been established in 1985 and 1986, based on an overall review of existing processes. The basis of the design were fixed in 1987, and a technology transfer agreement (TTA) was signed between JNFL and SGN, representative of CEA (French atomic energy commission) and COGEMA (which became now AREVA NC). The paper will describe the process, and then will focus on the main design, construction and tests steps, including a general schedule. It will emphasize the strong relationship between design teams of SGN and Japanese Makers during the design phases and between AREVA NC and JNFL during test operations. For the most sensitive part of the process, pilot facilities has been set up in Japan to allow a smooth knowledge transfer. One of the highlights during design phases was the rationalization study performed in mid-90. It allowed to incorporate in the design of Rokkasho reprocessing plant the lessons learned from UP3 start-up and to simplify the process. At the end of the design phase, in 2001, JNFL and AREVA NC decided to deeply strengthen their cooperation, in particular in the fields of the test operation such as chemical, uranium and active tests. This global assistance to be performed by AREVA NC to JNFL was very innovative, and included training session for Japanese operators in UP3 plant at La Hague. The main steps of the tests, water tests, chemical tests, uranium tests and active tests, will then be described. The TTA included a number of guarantee values which have been checked during the tests. The most important ones will be given with the actual results achieved in the Rokkasho plant. The success of this project could be an example of international cooperation for similar

  1. Regional Neonatal Associates for cooperative study of platelet-activating factor (PAF). Summary report

    Snyder, F.

    1992-11-01

    Lipid inflammatory mediators are thought to play an important role in the pathogenesis of the respiratory distress syndrome, including neonatal lung injury and bronchopulmonary dysplasia (BPD). One such mediator is platelet-activating factor (PAF), a potent bioactive phospholipid that induces adverse airway, vascular, and microcirculatory responses. To study the role of PAF in neonatal lung disease, we used an {sup 125}I-radioimmunoassay to measure PAF in whole blood and tracheal lavage in very low birthweight infants at 1, 3, 5, 9, 21 and 28 days after birth. PAF was found in the pulmonary lavagate and blood of ventilated infants as early as one day after birth. Lavagate levels of PAF increased with acute injury (pneumothorax, pneumonia) but were not associated with BPD. Our results indicate PAF could be associated with the pathogenesis of BPD. We suggest that as a consequence of the pathophysiologic processes associated with BPD, PAF is released by pulmonary cells. Our preliminary data indicate that low birthweight infants also have lower PAF acetylhydrolase levels in cord blood and tracheal lavagate as compared to adults. Therefore, it is possible the increased levels of PAF in the blood of low birthweight infants might be due to persistent transient increases in PAF alveolar levels coupled with lower blood acetylhydrolase activities and could be important in the development of symptoms associated with BPD. Future plans for this project call for completing the enzymatic study of acetylhydrolase activity in pulmonary lavage of the BPD infants.

  2. Loss of function of TET2 cooperates with constitutively active KIT in murine and human models of mastocytosis.

    Serena De Vita

    Full Text Available Systemic Mastocytosis (SM is a clonal disease characterized by abnormal accumulation of mast cells in multiple organs. Clinical presentations of the disease vary widely from indolent to aggressive forms, and to the exceedingly rare mast cell leukemia. Current treatment of aggressive SM and mast cell leukemia is unsatisfactory. An imatinib-resistant activating mutation of the receptor tyrosine kinase KIT (KIT D816V is most frequently present in transformed mast cells and is associated with all clinical forms of the disease. Thus the etiology of the variable clinical aggressiveness of abnormal mast cells in SM is unclear. TET2 appears to be mutated in primary human samples in aggressive types of SM, suggesting a possible role in disease modification. In this report, we demonstrate the cooperation between KIT D816V and loss of function of TET2 in mast cell transformation and demonstrate a more aggressive phenotype in a murine model of SM when both mutations are present in progenitor cells. We exploit these findings to validate a combination treatment strategy targeting the epigenetic deregulation caused by loss of TET2 and the constitutively active KIT receptor for the treatment of patients with aggressive SM.

  3. Statement delivered in the Board of Governors on 27 November 2008 by the Governor for Japan concerning Japan's activities in technical cooperation

    On 27 November 2008, the Governor of Japan delivered a statement in the Board of Governors concerning Japan's activities in technical cooperation. As requested in that statement, the full text of the statement is herewith circulated for the information of Member States

  4. Multiple cooperative interactions constrain BPV-1 E2 dependent activation of transcription.

    Sowden, M; Harrison, S; Ashfield, R.; Kingsman, A J; Kingsman, S M

    1989-01-01

    Transcription directed by the BPV-1 long control region (LCR) is conditional upon activation by the virally encoded E2 protein. Within the 1.0 kb LCR there are five separate regions, A to E, that contain E2 responsive enhancers. The smallest functional region, A, is only 38 bp and contains two copies of the consensus sequence ACC(N)6GGT that is known to function as an E2 binding site in vitro. We show that a pair of these constitutes a minimal functional E2 responsive enhancer element but tha...

  5. Distinct and cooperative activities of HESO1 and URT1 nucleotidyl transferases in microRNA turnover in Arabidopsis.

    Bin Tu

    2015-04-01

    Full Text Available 3' uridylation is increasingly recognized as a conserved RNA modification process associated with RNA turnover in eukaryotes. 2'-O-methylation on the 3' terminal ribose protects micro(miRNAs from 3' truncation and 3' uridylation in Arabidopsis. Previously, we identified HESO1 as the nucleotidyl transferase that uridylates most unmethylated miRNAs in vivo, but substantial 3' tailing of miRNAs still remains in heso1 loss-of-function mutants. In this study, we found that among nine other potential nucleotidyl transferases, UTP:RNA uridylyltransferase 1 (URT1 is the single most predominant nucleotidyl transferase that tails miRNAs. URT1 and HESO1 prefer substrates with different 3' end nucleotides in vitro and act cooperatively to tail different forms of the same miRNAs in vivo. Moreover, both HESO1 and URT1 exhibit nucleotidyl transferase activity on AGO1-bound miRNAs. Although these enzymes are able to add long tails to AGO1-bound miRNAs, the tailed miRNAs remain associated with AGO1. Moreover, tailing of AGO1-bound miRNA165/6 drastically reduces the slicing activity of AGO1-miR165/6, suggesting that tailing reduces miRNA activity. However, monouridylation of miR171a by URT1 endows the miRNA the ability to trigger the biogenesis of secondary siRNAs. Therefore, 3' tailing could affect the activities of miRNAs in addition to leading to miRNA degradation.

  6. PPARδ activation acts cooperatively with 3-phosphoinositide-dependent protein kinase-1 to enhance mammary tumorigenesis.

    Claire B Pollock

    Full Text Available Peroxisome proliferator-activated receptorδ (PPARδ is a transcription factor that is associated with metabolic gene regulation and inflammation. It has been implicated in tumor promotion and in the regulation of 3-phosphoinositide-dependent kinase-1 (PDK1. PDK1 is a key regulator of the AGC protein kinase family, which includes the proto-oncogene AKT/PKB implicated in several malignancies, including breast cancer. To assess the role of PDK1 in mammary tumorigenesis and its interaction with PPARδ, transgenic mice were generated in which PDK1 was expressed in mammary epithelium under the control of the MMTV enhancer/promoter region. Transgene expression increased pT308AKT and pS9GSK3β, but did not alter phosphorylation of mTOR, 4EBP1, ribosomal protein S6 and PKCα. The transgenic mammary gland also expressed higher levels of PPARδ and a gene expression profile resembling wild-type mice maintained on a diet containing the PPARδ agonist, GW501516. Both wild-type and transgenic mice treated with GW501516 exhibited accelerated rates of tumor formation that were more pronounced in transgenic animals. GW501516 treatment was accompanied by a distinct metabolic gene expression and metabolomic signature that was not present in untreated animals. GW501516-treated transgenic mice expressed higher levels of fatty acid and phospholipid metabolites than treated wild-type mice, suggesting the involvement of PDK1 in enhancing PPARδ-driven energy metabolism. These results reveal that PPARδ activation elicits a distinct metabolic and metabolomic profile in tumors that is in part related to PDK1 and AKT signaling.

  7. Research Activities of the SEP (Dutch cooperation of electric utilities) in the field of wind energy

    The Dutch electric utilities are actively involved in the development of the wind energy technology. The Dutch Integral research Program Wind energy (IPW) is an important stimulator for the development and the market of cost-effective wind turbines. The successful introduction of wind turbines however depends also on the expectations of potential users on the possible benefits which can be realized by the implementation of wind turbines. The wind pattern of a specific site is of great interest in the decision making, as well as the electric power demand and the availability of alternatives. Next to reliable data on wind potentials good simulation methods and evaluation techniques play important parts. The SEP realized a wind measuring network to collect data on the availability of wind on relevant heights. In combination with calculation models to analyze wind energy, thorough studies in the field of wind energy applications have been carried out during the last few years. Some results of these studies are presented. 10 figs., 2 tabs

  8. To Master the Methods of Cooperative Learning through the Cooperative Learning Activities%如何让教师在合作学习活动中掌握合作学习方法

    王鉴; 李泽林

    2012-01-01

    The effect of cooperative learning depends on the teacher's comprehension of its concept and the mastery of its methods. During the training, it proves to be effective to master the methods of cooperative learning through cooperative learning activities. Five basic questions are put forward in this teaching attempt, which will be constantly advanced through individual learning, desk mate learning, group learning and whole class learning. This teaching attempt enables the trainees to form a rational cognition of cooperative learning and then transform their ideas about it, and it also enables the trainees to participate in the process and experience the methods. The cooperative learning model formed in this teaching attempt can be applied to other aspects of training, in addition, it can be applied to the classroom activities through teacher's transferring.%合作学习的效果取决于教师对于合作学习理念的理解与方法的掌握。在教师培训过程中,通过合作学习活动让教师掌握合作学习方法,是一种十分有效的途径。这一活动通过对合作学习五个基本问题的个体学习、同桌学习、小组学习、全班共享学习的不断推进,不仅让学员形成关于合作学习的理性认识并转变其观念,而且让教师参与式体验了合作学习的过程与方法。此项活动所形成的学习模式,不仅可以运用到教师培训的其他方面,而且可以通过教师的迁移运用到其课堂教学活动中学生的合作学习过程之中。

  9. Behavioral Economics, Wearable Devices, and Cooperative Games: Results From a Population-Based Intervention to Increase Physical Activity

    2016-01-01

    exchanged GOODcoins, the mean balance was 4,000 (95% CI 3850, 4150) at time of redemption, and 50.4% (n=61) of exchanges were for fitness or outdoor products, while 4.1% (n=5) were for food-related items. Participants were most likely to complete challenges when rewards were between 201-300 GOODcoins. Conclusions The purpose of this study is to form a baseline for future research. Overall, results indicate that challenges and incentives may be effective for connected and active members, and may play a role in achieving daily-recommended activity guidelines. Registrants were typically younger, walking was the primary activity, and rewards were mainly exchanged for fitness or outdoor products. Remaining to be determined is whether members were already physically active at time of registration and are representative of healthy adherers, or were previously inactive and were incentivized to change their behavior. As challenges are gamified, there is an opportunity to investigate the role of superusers and healthy adherers, impacts on behavioral norms, and how cooperative games and incentives can be leveraged across stratified populations. Study limitations and future research agendas are discussed. PMID:26821955

  10. Synchrony and cooperation.

    Wiltermuth, Scott S; Heath, Chip

    2009-01-01

    Armies, churches, organizations, and communities often engage in activities-for example, marching, singing, and dancing-that lead group members to act in synchrony with each other. Anthropologists and sociologists have speculated that rituals involving synchronous activity may produce positive emotions that weaken the psychological boundaries between the self and the group. This article explores whether synchronous activity may serve as a partial solution to the free-rider problem facing groups that need to motivate their members to contribute toward the collective good. Across three experiments, people acting in synchrony with others cooperated more in subsequent group economic exercises, even in situations requiring personal sacrifice. Our results also showed that positive emotions need not be generated for synchrony to foster cooperation. In total, the results suggest that acting in synchrony with others can increase cooperation by strengthening social attachment among group members. PMID:19152536

  11. CEDEX's supporting activities through the Cooperation fund for Water and Sanitation; Apoyo del CEDEX a las actuaciones del Fondo de cooperacion para Agua y Saneamiento

    Rio Marrero, I. del

    2015-07-01

    This paper deals with the activities CEDEX has being doing since 2012, Giving Technical support to the cooperation fund for Water and Sanitation (Fondo de Cooperacion para Agua y Saneamiento-FCAS), of the Spanish Agency for International Development Cooperation. Throughout the document, the different activities carried out by the CEDEX up to now, are briefly described. They have mainly consisted in giving technical support during the formulation, review and monitoring of the tasks derived from the FCAS programs, capacity buildings, and preparing technical guides and recommendations concerning different subjects. The FCAS programs concerns water planning water supply and sanitation planning as well as water supply and sanitation (sewerage and wastewater treatment plants) construction projects. The paper ends up presenting a set of conclusions and lessons learned extracted from this period working for the FCAS, as well as the main courses of action projected for the future collaboration works. (Author)

  12. Activated KRAS Cooperates with MLL-AF4 to Promote Extramedullary Engraftment and Migration of Cord Blood CD34+ HSPC But Is Insufficient to Initiate Leukemia.

    Prieto, Cristina; Stam, Ronald W; Agraz-Doblas, Antonio; Ballerini, Paola; Camos, Mireia; Castaño, Julio; Marschalek, Rolf; Bursen, Aldeheid; Varela, Ignacio; Bueno, Clara; Menendez, Pablo

    2016-04-15

    The MLL-AF4 (MA4) fusion gene is the genetic hallmark of an aggressive infant pro-B-acute lymphoblastic leukemia (B-ALL). Our understanding of MA4-mediated transformation is very limited. Whole-genome sequencing studies revealed a silent mutational landscape, which contradicts the aggressive clinical outcome of this hematologic malignancy. Only RAS mutations were recurrently detected in patients and found to be associated with poorer outcome. The absence of MA4-driven B-ALL models further questions whether MA4 acts as a single oncogenic driver or requires cooperating mutations to manifest a malignant phenotype. We explored whether KRAS activation cooperates with MA4 to initiate leukemia in cord blood-derived CD34(+) hematopoietic stem/progenitor cells (HSPC). Clonogenic and differentiation/proliferation assays demonstrated that KRAS activation does not cooperate with MA4 to immortalize CD34(+) HSPCs. Intrabone marrow transplantation into immunodeficient mice further showed that MA4 and KRAS(G12V) alone or in combination enhanced hematopoietic repopulation without impairing myeloid-lymphoid differentiation, and that mutated KRAS did not cooperate with MA4 to initiate leukemia. However, KRAS activation enhanced extramedullary hematopoiesis of MA4-expressing cell lines and CD34(+) HSPCs that was associated with leukocytosis and central nervous system infiltration, both hallmarks of infant t(4;11)(+) B-ALL. Transcriptional profiling of MA4-expressing patients supported a cell migration gene signature underlying the mutant KRAS-mediated phenotype. Collectively, our findings demonstrate that KRAS affects the homeostasis of MA4-expressing HSPCs, suggesting that KRAS activation in MA4(+) B-ALL is important for tumor maintenance rather than initiation. Cancer Res; 76(8); 2478-89. ©2016 AACR. PMID:26837759

  13. PREFACE: Cooperative dynamics Cooperative dynamics

    Gov, Nir

    2011-09-01

    The dynamics within living cells are dominated by non-equilibrium processes that consume chemical energy (usually in the form of ATP, adenosine triphosphate) and convert it into mechanical forces and motion. The mechanisms that allow this conversion process are mostly driven by the components of the cytoskeleton: (i) directed (polar) polymerization of filaments (either actin or microtubules) and (ii) molecular motors. The forces and motions produced by these two components of the cytoskeleton give rise to the formation of cellular shapes, and drive the intracellular transport and organization. It is clear that these systems present a multi-scale challenge, from the physics of the molecular processes to the organization of many interacting units. Understanding the physical nature of these systems will have a large impact on many fundamental problems in biology and break new grounds in the field of non-equilibrium physics. This field of research has seen a rapid development over the last ten years. Activities in this area range from theoretical and experimental work on the underlying fundamental (bio)physics at the single-molecule level, to investigations (in vivo and in vitro) of the dynamics and patterns of macroscopic pieces of 'living matter'. In this special issue we have gathered contributions that span the whole spectrum of length- and complexity-scales in this field. Some of the works demonstrate how active forces self-organize within the polymerizing cytoskeleton, on the level of cooperative cargo transport via motors or due to active fluxes at the cell membrane. On a larger scale, it is shown that polar filaments coupled to molecular motors give rise to a huge variety of surprising dynamics and patterns: spontaneously looping rings of gliding microtubules, and emergent phases of self-organized filaments and motors in different geometries. All of these articles share the common feature of being out-of-equilibrium, driven by metabolism. As demonstrated here

  14. Cooperative design

    Schmidt, Kjeld

    1998-01-01

    if concurrent engineering is to succeed. On the basis of ethnographic studies of cooperative design, the paper attempts to characterize cooperative work in the domain of design and to outline a set of crucial research problems to be addressed if CSCW is to help engineers and de-signers meet the challenges...... they are facing. On one hand, designers need highly flexible ‘coordination mecha-nisms’ that can support horizontal coordination of large-scale distributed design projects, and on the other hand design organizations require versatile and ubiquitous infrastructures to be able to manage their ‘common informa-tion...

  15. Cooperative transcription activation by Nurr1 and Pitx3 induces embryonic stem cell maturation to the midbrain dopamine neuron phenotype

    Martinat, Cecile; Bacci, Jean-Jacques; Leete, Thomas;

    2006-01-01

    , Pitx3, Lmx1b, Engrailed-1, and Engrailed-2. However, none of these factors appear sufficient alone to induce the mature midbrain DA neuron phenotype in ES cell cultures in vitro, suggesting a more complex regulatory network. Here we show that Nurr1 and Pitx3 cooperatively promote terminal maturation...

  16. The 1999 activities and the 1st seminar on human resources development in the nuclear field as part of Asian regional cooperation (contract research)

    NONE

    2000-12-01

    In August, 1999, the Project for Human Resources Development (HRD) was initiated as defined in the framework of the Forum for Nuclear Cooperation in Asia, organized by the Atomic Energy Commission based on a resolution of the 10th International Conference for Nuclear Cooperation in Asia, held in March, 1999. The resolution was adopted as a recognition that 'human resources development' was an important area that should be added to the existing fields of cooperation. The Project was organized by the Atomic Energy Bureau of the Science and Technology Agency (STA) and is administrated by the Nuclear Technology and Education Center (NuTEC) of the Japan Atomic Energy Research Institute. The objective of the HRD Project is to solidify the foundation of technologies for nuclear development and utilization in Asia by promoting human resources development in Asian countries. In the Project there are two kind of activities: in-workshop activities and outside-of-workshop activities, as the time of the workshops themselves is too short to achieve the objectives. As In-workshop activities, 1st Seminar on Human Resources Development in the Nuclear Field was held on November 25 and 26, 1999, at the Tokyo International Forum. Participating countries were China, Indonesia, South Korea, Japan, Malaysia, the Philippines, Thailand, and Vietnam, with Australia submitting a study report only. This report consists of presentation papers at the Seminar as in-workshop activities, and a letter of proposal from the project leader of Japan to the project leaders of participating countries after the Seminar and a presentation paper on Human Resources Development at the First Coordinators Meeting on March 7 and 8, 2000 as outside-of-workshop activities. The 10 of the presented papers are indexed individually. (J.P.N.)

  17. The 1999 activities and the 1st seminar on human resources development in the nuclear field as part of Asian regional cooperation (contract research)

    In August, 1999, the Project for Human Resources Development (HRD) was initiated as defined in the framework of the Forum for Nuclear Cooperation in Asia, organized by the Atomic Energy Commission based on a resolution of the 10th International Conference for Nuclear Cooperation in Asia, held in March, 1999. The resolution was adopted as a recognition that 'human resources development' was an important area that should be added to the existing fields of cooperation. The Project was organized by the Atomic Energy Bureau of the Science and Technology Agency (STA) and is administrated by the Nuclear Technology and Education Center (NuTEC) of the Japan Atomic Energy Research Institute. The objective of the HRD Project is to solidify the foundation of technologies for nuclear development and utilization in Asia by promoting human resources development in Asian countries. In the Project there are two kind of activities: in-workshop activities and outside-of-workshop activities, as the time of the workshops themselves is too short to achieve the objectives. As In-workshop activities, 1st Seminar on Human Resources Development in the Nuclear Field was held on November 25 and 26, 1999, at the Tokyo International Forum. Participating countries were China, Indonesia, South Korea, Japan, Malaysia, the Philippines, Thailand, and Vietnam, with Australia submitting a study report only. This report consists of presentation papers at the Seminar as in-workshop activities, and a letter of proposal from the project leader of Japan to the project leaders of participating countries after the Seminar and a presentation paper on Human Resources Development at the First Coordinators Meeting on March 7 and 8, 2000 as outside-of-workshop activities. The 10 of the presented papers are indexed individually. (J.P.N.)

  18. ENHANCING COOPERATION

    2007-01-01

    China and Japan can cooperate on a wide scope of issues, such as the organization of the Beijing Olympic Games next year and aid to Africa,said Ide Keiji, Minister of Public Relations, Press, Culture, Education and Sports and Spokesperson of the Embassy

  19. Indian Ocean Rim Cooperation

    Wippel, Steffen

    Since the mid-1990s, the Indian Ocean has been experiencing increasing economic cooperation among its rim states. Middle Eastern countries, too, participate in the work of the Indian Ocean Rim Association, which received new impetus in the course of the current decade. Notably Oman is a very active...

  20. Cooperative Learning and Teaching

    Jacobs, G. M.; Kimura, H.

    2013-01-01

    In and out of the classroom, life would be unthinkable without interacting with fellow humans. This book urges more cooperative and group activities in the English language classroom for all the advantages: students use the target language more, help each other with comprehension, receive attention from peers as well as the teacher, are motivated…

  1. Nordic Energy Policy Cooperation

    Jørgensen, Birte Holst

    2016-01-01

    for Nordic projects of common interests. This created the necessary critical knowledge base in new energy technologies, energy systems and energy markets. Nordic energy policy cooperation followed the ordinary Nordic governance structures, rules and mode of operation with Council of Ministers, supported...... by a committee of senior officials and a secretariat. This was characterised by an incremental development of the cooperation based on consensus, mutual understanding and trust facilitated through exchange of experiences, work groups, seminars, educational activities and mobility schemes for energy policy...

  2. An fMRI study of joint action–varying levels of cooperation correlates with activity in control networks

    Chaminade, Thierry; Marchant, Jennifer L.; Kilner, James; Frith, Christopher D

    2012-01-01

    As social agents, humans continually interact with the people around them. Here, motor cooperation was investigated using a paradigm in which pairs of participants, one being scanned with fMRI, jointly controlled a visually presented object with joystick movements. The object oscillated dynamically along two dimensions, color and width of gratings, corresponding to the two cardinal directions of joystick movements. While the overall control of each participant on the object was kept constant,...

  3. The Delta Cooperative Model: a Dynamic and Innovative Team-Work Activity to Develop Research Skills in Microbiology

    Carlos Rios-Velazquez; Reynaldo Robles-Suarez; Alberto J. Gonzalez-Negron; Ivan Baez-Santos

    2006-01-01

    The Delta Cooperative Model (DCM) is a dynamic and innovative teamwork design created to develop fundamentals in research skills. High school students in the DCM belong to the Upward Bound Science and Math (UBSM) program at the Inter American University, Ponce Campus. After workshops on using the scientific method, students were organized into groups of three students with similar research interests. Each student had to take on a role within the group as either a researcher, data analyst, or ...

  4. Cooperative Innovation

    Mingzhuan, Huang

    2013-01-01

    The current companies increasingly expect to involve more external sources to achieve more open innovation for value-added. However, the cooperation problem between internal organization and external parties still challenges the top management. This paper aims to find out the solution. The fast spring up Chinese IT market impacts the world market, especially mobile Internet. Therefore, this paper employ the fast growing Chinese Mobile Internet company--- Xiao Mi as the study case. By applying...

  5. International co-operation

    In 1996, Nuclear Regulatory Authority of the Slovak Republic (NRA SR) ensured the Slovak Republic (SR) obligations with relation to the international agreements and with the SR membership in the IAEA.International co-operation has been ensured on the basis of the bilateral international agreements. With the Ministry of Foreign Affairs co-operation, the SR fulfilled its financial obligations to this organization in due time and in the full scope. Representing Central and Eastern Europe interest in the Board of Governors, the SR participation in the highest executive in the highest executive authority was finished in 1996.The Board of Governors Vice-chairman position was executed by NRA SR Chairman. 5 national and 6 regional technical co-operation and assistance projects were realized in 1996. 12 organizations participated in these projects and accordingly 104 experts took part in training programmes, scientific visits or as the mission members abroad. Besides, Slovak experts participated at work of technical advisory and consultation groups with the significant assistance. In the framework of IAEA co-operation, the SR was visited by 11 expert missions formed by 28 experts from 19 countries including IAEA. Slovak organizations, namely institutes of the Academy of Sciences, Slovak research centres and universities participated in IAEA scientific and research activities through NRA SR. 15 scientific contracts in total were approved and realized and these contracts are utilized as supplementary financing of the own scientific and research projects. Other international co-operation and regional co-operation activities of the NRA SR in 1996 are reviewed

  6. Cooperative Transcriptional Activation of Antimicrobial Genes by STAT and NF-κB Pathways by Concerted Recruitment of the Mediator Complex.

    Wienerroither, Sebastian; Shukla, Priyank; Farlik, Matthias; Majoros, Andrea; Stych, Bernadette; Vogl, Claus; Cheon, HyeonJoo; Stark, George R; Strobl, Birgit; Müller, Mathias; Decker, Thomas

    2015-07-14

    The transcriptional response to infection with the bacterium Listeria monocytogenes (Lm) requires cooperative signals of the type I interferon (IFN-I)-stimulated JAK-STAT and proinflammatory NF-κB pathways. Using ChIP-seq analysis, we define genes induced in Lm-infected macrophages through synergistic transcriptional activation by NF-κB and the IFN-I-activated transcription factor ISGF3. Using the Nos2 and IL6 genes as prime examples of this group, we show that NF-κB functions to recruit enzymes that establish histone marks of transcriptionally active genes. In addition, NF-κB regulates transcriptional elongation by employing the mediator kinase module for the recruitment of the pTEFb complex. ISGF3 has a major role in associating the core mediator with the transcription start as a prerequisite for TFIID and RNA polymerase II (Pol II) binding. Our data suggest that the functional cooperation between two major antimicrobial pathways is based on promoter priming by NF-κB and the engagement of the core mediator for Pol II binding by ISGF3. PMID:26146080

  7. The cooperation of the functional activation areas in human brain: an application of event-related fMRI study of the voluntary motor function

    Objective: To detect the cooperation of the functional activation areas in human brain using event-related fMRI technique developed in recent years. Methods: Forty-four subjects were selected in this experiment and scanned by GE Signa Horizon 1.5 Tesla superconductive MR system. A CUE-GO paradigm was used in this experiment. The data were analyzed in SUN and SGI workstation. Results: The activation areas were found in contralateral primary motor area (Ml), bilateral supplementary motor areas (SMA), pre-motor areas (PMA), basal ganglia, and cerebellar cortices. The time-signal curve of Ml was a typical single-peak curve, but the curves in PMA, basal ganglia, and cerebellar cortices were double-peak curves. SMA had 2 parts, one was Pre-SMA, and another was SMA Proper. The curve was double-peak type in Pre-SMA and single-peak type in SMA Proper. There was difference between the time-signal intensity curves in above-mentioned areas. Conclusion: (1) Ml is mainly associated with motor execution, while others with both motor preparation and execution. There are differences in the function at the variant areas in the brain. (2) The fact that bilateral SMA, PMA, basal ganglia, and cerebellar cortices were activated, is different from what the classical theories told. (3) Event-related fMRI technique has higher temporary and spatial resolutions. (4) There is cooperation among different cortical areas, basal ganglia, and cerebellum

  8. Cooperative Transcriptional Activation of Antimicrobial Genes by STAT and NF-κB Pathways by Concerted Recruitment of the Mediator Complex

    Sebastian Wienerroither

    2015-07-01

    Full Text Available The transcriptional response to infection with the bacterium Listeria monocytogenes (Lm requires cooperative signals of the type I interferon (IFN-I-stimulated JAK-STAT and proinflammatory NF-κB pathways. Using ChIP-seq analysis, we define genes induced in Lm-infected macrophages through synergistic transcriptional activation by NF-κB and the IFN-I-activated transcription factor ISGF3. Using the Nos2 and IL6 genes as prime examples of this group, we show that NF-κB functions to recruit enzymes that establish histone marks of transcriptionally active genes. In addition, NF-κB regulates transcriptional elongation by employing the mediator kinase module for the recruitment of the pTEFb complex. ISGF3 has a major role in associating the core mediator with the transcription start as a prerequisite for TFIID and RNA polymerase II (Pol II binding. Our data suggest that the functional cooperation between two major antimicrobial pathways is based on promoter priming by NF-κB and the engagement of the core mediator for Pol II binding by ISGF3.

  9. Outlook on non-proliferation activities in the world and cooperation in peaceful uses of nuclear energy among Turkish speaking countries

    Nuclear technology is being widely used in protecting the environment, manufacturing industry, medicine, agriculture, food industry and electricity production. In the world, 438 nuclear power plants are in operation, and 31 are under construction. Nuclear share of total electricity generation have reached to 17 percent. However, 2053 nuclear tests from 1945 to 1999 and 2 atom bombs to Hiroshima and Nagasaki in 1945 have initiated nonproliferation activities aiming to halt the spread of nuclear weapons and to create a climate where cooperation in the peaceful uses of nuclear energy can be fostered. In addition to international efforts for non-proliferation of nuclear weapons, great efforts were made for disarmament and banning the nuclear tests which damage the environment. Following the first Geneva Conference in 1955 for expanding peaceful uses of nuclear energy, Turkey was one of the first countries to start activities in the nuclear field. Turkish Atomic Energy Authority (TAEK) was established in 1956 and Turkey became a member of the International Atomic Energy Agency established in 1957 by the United Nations for spreading the use of nuclear energy to contribute peace, health and prosperity throughout the world in same year. Turkey is a candidate state to join to European Union and has already signed Custom Union Agreement, also part of the Eurasian Region. So, there are significant developments in cultural, social, technical, economical and trade relations owning to our common historical and cultural values with the countries in the region and Central Asia. TAEK was established to support, co-ordinate and perform the activities in peaceful uses of nuclear energy and act as a regulatory body and establish cooperation with countries and international organizations. In the late 1990's TAEK, besides the cooperation with various countries, has involved to cooperating with nuclear institutes of Azerbaijan, Kazakhstan, Kyrgyzstan, Uzbekistan and Turkmenistan for

  10. Cooperative Learning: An Inside Story.

    Andre, Kathleen M.

    1999-01-01

    Describes students' reactions to a university physics class for engineering majors that was built around cooperative learning activities. Finds that student feedback supports research claims made about the learning benefits of this teaching method. (WRM)

  11. Metal-ligand cooperation.

    Khusnutdinova, Julia R; Milstein, David

    2015-10-12

    Metal-ligand cooperation (MLC) has become an important concept in catalysis by transition metal complexes both in synthetic and biological systems. MLC implies that both the metal and the ligand are directly involved in bond activation processes, by contrast to "classical" transition metal catalysis where the ligand (e.g. phosphine) acts as a spectator, while all key transformations occur at the metal center. In this Review, we will discuss examples of MLC in which 1) both the metal and the ligand are chemically modified during bond activation and 2) bond activation results in immediate changes in the 1st coordination sphere involving the cooperating ligand, even if the reactive center at the ligand is not directly bound to the metal (e.g. via tautomerization). The role of MLC in enabling effective catalysis as well as in catalyst deactivation reactions will be discussed. PMID:26436516

  12. SOCS-1 gene delivery cooperates with cisplatin plus pemetrexed to exhibit preclinical antitumor activity against malignant pleural mesothelioma.

    Iwahori, Kota; Serada, Satoshi; Fujimoto, Minoru; Ripley, Barry; Nomura, Shintaro; Mizuguchi, Hiroyuki; Shimada, Kazuki; Takahashi, Tsuyoshi; Kawase, Ichiro; Kishimoto, Tadamitsu; Naka, Tetsuji

    2013-01-15

    Malignant pleural mesothelioma (MPM) is an aggressive tumor with poor prognosis for which an effective therapy remains to be established. This study investigated the therapeutic potential of gene delivery using suppressor of cytokine signaling 1 (SOCS-1), an endogenous inhibitor of intracellular signaling pathways, for the treatment of MPM. We infected MPM cells (MESO-4, H28 and H226) with adenovirus-expressing SOCS-1 vector to examine the effect of SOCS-1 overexpression on MPM cells. We evaluated the antitumor effect of SOCS-1 gene delivery combined with cisplatin plus pemetrexed by cell proliferation, apoptosis and invasion assay. We also investigated the regulation of NF-κB and STAT3 signaling related to apoptotic pathways. Furthermore, we evaluated the inhibition of tumor growth by SOCS-1 gene delivery combined with cisplatin plus pemetrexed in vivo. SOCS-1 gene delivery cooperated with cisplatin plus pemetrexed to inhibit cell proliferation, invasiveness and induction of apoptosis in MPM cells. SOCS-1 regulated NF-κB and STAT3 signaling to induce apoptosis in MESO-4 and H226 cells. Furthermore, SOCS-1 gene delivery cooperated with cisplatin plus pemetrexed to regulate NF-κB signaling and significantly inhibit tumor growth of MPM in vivo. These results suggest that SOCS-1 gene delivery has a potent antitumor effect against MPM and a potential for clinical use in combination with cisplatin plus pemetrexed. PMID:22532243

  13. Activities of Project 'Cooperation and development with Latin America and Iberian in Biological Dosimetry of Iberian Group of Radiation Protection Societies

    In 1996 the GRIAPRA Group (Latin American and Iberian Group of Radiation Protection Societies) was established with the participation of Argentina, Brazil, Cuba, Mexico, Peru, Portugal and Spain. In 1998 began the biennial Collaborative Working Project 'Cooperation and Development with Latin America in Biological Dosimetry', partially supported by the Extremadura Government, Spain, initially involving five countries: Argentina, Cuba, Peru, Portugal and Spain. The general aim of the project is to create an Latin American and Iberian Biological Dosimetry Laboratories Coordinated Group in order to: give mutual cooperation and to other countries if required, in the case of radiological accident; contribute to enhance the technical capabilities of the participant laboratories; promote the installment of laboratories on this field in countries that does not have it yet through the training of human resources and providing the necessary equipment and, finally, perform jointly research activities in biological dosimetry. The activities designed in order to accomplish the project specific aims for the 1998-2000 period have been achieved. Description and results are presented. (author)

  14. EXAMINING THE DYNAMICS OF COOPERATION BETWEEN COMPETING FIRMS IN THEIR R&D ACTIVITIES (R&D CO-OPETITION

    Fakhraddin Maroofi

    2015-11-01

    Full Text Available The relationship between collaboration with competitors and goods innovation performance was investigated along with the moderating effect of the innovating firm's technological capability. The hypothesis that collaboration with competitors has an inverted U-shaped relationship with goods innovation performance was tested using data on new goods introductions from 749 Iranian firms. The results support the balance between competition and collaboration by confirming that collaboration with competitors contributes considerably to successful goods innovation. The positive influences of co-optation certainly seem consistent with the cooperative arguments that collaboration with competitors increases absorptive capacity, improves information exchange and facilitates joint problem solving. The results also show that unnecessary collaboration with competitors can have a negative influence on innovation performance, raising concerns about opportunistic exploitation. The results support the existence of a bell-shaped relationship between application and goods innovation performance. Technological capability and alliances with universities were shown to weaken the relationship.

  15. Cooperative Dimensions of a Digitization Project

    Adaryukov, Andrew

    2004-01-01

    After a brief overview of the digitization activities at Florida Atlantic University Libraries, this article describes one project in detail, concentrating on various types of cooperation it reflects.

  16. [Social cooperatives in Italy].

    Villotti, P; Zaniboni, S; Fraccaroli, F

    2014-06-01

    This paper describes the role of social cooperatives in Italy as a type of economic, non-profit organization and their role in contributing to the economic and social growth of the country. The purpose of this paper is to learn more about the experience of the Italian social cooperatives in promoting the work integration process of disadvantaged workers, especially those suffering from mental disorders, from a theoretical and an empirical point of view. Social enterprise is the most popular and consolidated legal and organizational model for social enterprises in Italy, introduced by Law 381/91. Developed during the early 1980s, and formally recognized by law in the early 1990s, social cooperatives aim at pursuing the general interest of the community to promote the human needs and social inclusion of citizens. They are orientated towards aims that go beyond the interest of the business owners, the primary beneficiary of their activities is the community, or groups of disadvantaged people. In Italy, Law 381/91 distinguishes between two categories of social cooperatives, those producing goods of social utility, such as culture, welfare and educational services (A-type), and those providing economic activities for the integration of disadvantaged people into employment (B-type). The main purpose of B-type social cooperatives is to integrate disadvantaged people into the open labour market. This goal is reached after a period of training and working experience inside the firm, during which the staff works to improve both the social and professional abilities of disadvantaged people. During the years, B-type social co-ops acquired a particular relevance in the care of people with mental disorders by offering them with job opportunities. Having a job is central in the recovery process of people suffering from mental diseases, meaning that B-type social co-ops in Italy play an important rehabilitative and integrative role for this vulnerable population of workers. The

  17. THE MARKETING OF COOPERATIVE SOCIETIES

    Razvan-Nicolae, DECUSEARA; Sorin-Daniel, MANOLE

    2013-01-01

    Cooperatives have proven to be a business model that has endured over time, even during the economic crisis. Even if they don’t have the scale of large companies, they manage, through their ability to adapt, to overcome challenges offered by the market they are acting. The fact that their members are working in these cooperatives makes them to engage more actively in cooperative work and also to be more responsible, in the end, working for them. Even if they don’t have marketing budgets, coop...

  18. Tumor promoter-like activity of the molluscicidal latex of 'Crown-of-Thorns' (Euphorbia milii var. hislopii) in the V79 metabolic cooperation assay.

    Cruz, C M; Kasper, P; Cataldo, A; Zamith, H P; Paumgartten, F J

    1996-11-01

    The latex of 'Crown-of-Thorns' (Euphorbia milii var. hislopii, syn. E. splendens) has been shown to be a potent plant molluscicide that could be used against the snails which are intermediate hosts of Schistosoma trematodes. However, a comprehensive toxicological evaluation of the latex is necessary before its large-scale use in schistosomiasis control becomes possible. In fact, one cause for concern is the presence of tumor-promoting phorbol esters in several plants of the Euphorbiaceae family. Phorbol esters as well as a number of other known tumor promoters share the common property of inhibiting metabolic cooperation (i.e., exchange of low molecular weight molecules via gap junctions) between Chinese hamster V79 cells in monolayer cultures. The present study was undertaken to determine if latex of E. milii presents tumor promoter-like activity is this short-term in vitro assay. Samples of lyophilized E. milii latex were tested at a noncytotoxic concentration range (1, 10, 50 and 100 micrograms/ml) in three independent experiments. 12-O-Tetradecanoylphorbol-13-acetate (10 ng/ml) was used as positive control. In all three assays, E. milii latex consistently inhibited metabolic cooperation between V79 cells at concentrations > or = 10 micrograms/ml. These results that E. milii latex contains tumor-promoting substances. These findings suggest that the use of crude latex as a molluscicide may pose a carcinogenic hazard to people who are continuously exposed to the product. PMID:9196556

  19. TLR9 is required for MAPK/NF-κB activation but does not cooperate with TLR2 or TLR6 to induce host resistance to Brucella abortus.

    Gomes, Marco Túlio; Campos, Priscila Carneiro; Pereira, Guilherme de Sousa; Bartholomeu, Daniella Castanheira; Splitter, Gary; Oliveira, Sergio Costa

    2016-05-01

    Brucella abortus is a Gram-negative intracellular bacterial pathogen that causes a zoonosis of worldwide occurrence, leading to undulant fever in humans and abortion in domestic animals. B. abortus is recognized by several pattern-recognition receptors triggering pathways during the host innate immune response. Therefore, here, we determined the cooperative role of TLR9 with TLR2 or TLR6 receptors in sensing Brucella Furthermore, we deciphered the host innate immune response against B. abortus or its DNA, emphasizing the role of TLR9-MAPK/NF-κB signaling pathways in the production of proinflammatory cytokines. TLR9 is required for the initial host control of B. abortus, but this TLR was dispensable after 6 wk of infection. The susceptibility of TLR9(-/-)-infected animals to Brucella paralleled with lower levels of IFN-γ produced by mouse splenocytes stimulated with this pathogen compared with wild-type cells. However, no apparent cooperative interplay was observed between TLR2-TLR9 or TLR6-TLR9 receptors to control infection. Moreover, B. abortus or its DNA induced activation of MAPK/NF-κB pathways and production of IL-12 and TNF-α by macrophages partially dependent on TLR9 but completely dependent on MyD88. In addition, B. abortus-derived CpG oligonucleotides required TLR9 to promote IL-12 and TNF-α production by macrophages. By confocal microscopy, we demonstrated that TLR9 redistributed and colocalized with lysosomal-associated membrane protein-1 upon Brucella infection. Thus, B. abortus induced TLR9 traffic, leading to cell signaling activation and IL-12 and TNF-α production. Although TLR9 recognized Brucella CpG motifs, our results suggest a new pathway of B. abortus DNA-activating macrophages independent of TLR9. PMID:26578650

  20. Apoptotic efficacy of etomoxir in human acute myeloid leukemia cells. Cooperation with arsenic trioxide and glycolytic inhibitors, and regulation by oxidative stress and protein kinase activities.

    Estañ, María Cristina; Calviño, Eva; Calvo, Susana; Guillén-Guío, Beatriz; Boyano-Adánez, María Del Carmen; de Blas, Elena; Rial, Eduardo; Aller, Patricio

    2014-01-01

    Fatty acid synthesis and oxidation are frequently exacerbated in leukemia cells, and may therefore represent a target for therapeutic intervention. In this work we analyzed the apoptotic and chemo-sensitizing action of the fatty acid oxidation inhibitor etomoxir in human acute myeloid leukemia cells. Etomoxir caused negligible lethality at concentrations up to 100 µM, but efficaciously cooperated to cause apoptosis with the anti-leukemic agent arsenic trioxide (ATO, Trisenox), and with lower efficacy with other anti-tumour drugs (etoposide, cisplatin), in HL60 cells. Etomoxir-ATO cooperation was also observed in NB4 human acute promyelocytic cells, but not in normal (non-tumour) mitogen-stimulated human peripheral blood lymphocytes. Biochemical determinations in HL60 cells indicated that etomoxir (25-200 µM) dose-dependently inhibited mitochondrial respiration while slightly stimulating glycolysis, and only caused marginal alterations in total ATP content and adenine nucleotide pool distribution. In addition, etomoxir caused oxidative stress (increase in intracellular reactive oxygen species accumulation, decrease in reduced glutathione content), as well as pro-apoptotic LKB-1/AMPK pathway activation, all of which may in part explain the chemo-sensitizing capacity of the drug. Etomoxir also cooperated with glycolytic inhibitors (2-deoxy-D-glucose, lonidamine) to induce apoptosis in HL60 cells, but not in NB4 cells. The combined etomoxir plus 2-deoxy-D-glucose treatment did not increase oxidative stress, caused moderate decrease in net ATP content, increased the AMP/ATP ratio with concomitant drop in energy charge, and caused defensive Akt and ERK kinase activation. Apoptosis generation by etomoxir plus 2-deoxy-D-glucose was further increased by co-incubation with ATO, which is apparently explained by the capacity of ATO to attenuate Akt and ERK activation. In summary, co-treatment with etomoxir may represent an interesting strategy to increase the apoptotic

  1. Apoptotic efficacy of etomoxir in human acute myeloid leukemia cells. Cooperation with arsenic trioxide and glycolytic inhibitors, and regulation by oxidative stress and protein kinase activities.

    María Cristina Estañ

    Full Text Available Fatty acid synthesis and oxidation are frequently exacerbated in leukemia cells, and may therefore represent a target for therapeutic intervention. In this work we analyzed the apoptotic and chemo-sensitizing action of the fatty acid oxidation inhibitor etomoxir in human acute myeloid leukemia cells. Etomoxir caused negligible lethality at concentrations up to 100 µM, but efficaciously cooperated to cause apoptosis with the anti-leukemic agent arsenic trioxide (ATO, Trisenox, and with lower efficacy with other anti-tumour drugs (etoposide, cisplatin, in HL60 cells. Etomoxir-ATO cooperation was also observed in NB4 human acute promyelocytic cells, but not in normal (non-tumour mitogen-stimulated human peripheral blood lymphocytes. Biochemical determinations in HL60 cells indicated that etomoxir (25-200 µM dose-dependently inhibited mitochondrial respiration while slightly stimulating glycolysis, and only caused marginal alterations in total ATP content and adenine nucleotide pool distribution. In addition, etomoxir caused oxidative stress (increase in intracellular reactive oxygen species accumulation, decrease in reduced glutathione content, as well as pro-apoptotic LKB-1/AMPK pathway activation, all of which may in part explain the chemo-sensitizing capacity of the drug. Etomoxir also cooperated with glycolytic inhibitors (2-deoxy-D-glucose, lonidamine to induce apoptosis in HL60 cells, but not in NB4 cells. The combined etomoxir plus 2-deoxy-D-glucose treatment did not increase oxidative stress, caused moderate decrease in net ATP content, increased the AMP/ATP ratio with concomitant drop in energy charge, and caused defensive Akt and ERK kinase activation. Apoptosis generation by etomoxir plus 2-deoxy-D-glucose was further increased by co-incubation with ATO, which is apparently explained by the capacity of ATO to attenuate Akt and ERK activation. In summary, co-treatment with etomoxir may represent an interesting strategy to increase the

  2. The 2000 activities and the 2nd Workshop on Human Resources Development in the Nuclear Field as part of Asian regional cooperation

    In 1999, the Project for Human Resources Development (HRD) was initiated as defined in the framework of the Forum for Nuclear Cooperation in Asia (FNCA), organized by the Atomic Energy Commission of Japan. The objective of the HRD Project is to solidify the foundation of technologies for nuclear development and utilization in Asia by promoting human resources development in Asian countries. In the Project there are two kind of activities; in-workshop activities and outside-of-workshop activities. As in-workshop activities, the 2nd Workshop on Human Resources Development in the Nuclear Field was held on November 27 and 28, 2000, at the Tokai Research Institute of JAERI. As outside-of-workshop activities. 'The presentation of the present state of international training and education in the nuclear field in Japan' was held on November 29, 2000 after the workshop. Participating countries were China, Indonesia, South Korea, Japan, Malaysia, the Philippines, Thailand, and Vietnam. The secretariat for the Human Resources Development Projects is provided by the Nuclear Technology and Education Center of the Japan Atomic Energy Research Institute. This report consists of presentation papers and materials at the Workshop, presentation documents of 'The present state of international training and education in the nuclear field in Japan', a letter of proposal from the Project Leader of Japan to the project leaders of the participating countries after the Workshop and a presentation paper on Human Resources Development at the 3rd Coordinators Meeting of FNCA at Tokyo on March 14-16, 2001. (author)

  3. International cooperation

    Europe is certainly the part of the world where the largest number of international arrangements have been established for dealing with international cooperation in cases of major oil spills at sea. Let me list the most important of these multilateral arrangements: Bonn Agreement: covers the North Sea Contracting Parties: riparian states and the EEC Barcelona Convention: (protocol for emergency situations) covers the Mediterranean Sea Contracting Parties: riparian states and the EEC; Helsinki Convention: covers the Baltic Sea Contracting Parties: riparian states and (soon) the EEC; Lisbon Agreement: covers the NE Atlantic Contracting Parties: France, Spain, Portugal, Morocco and the EEC; Community Action Plan: covers the whole community waters; EEC; Members States participate in this plan. It should be underlined that, in addition to these large multilateral agreements a number of bilateral or trilateral arrangements have been set up, such as the Copenhagen Agreement, Denger Plan, Manche Plan, etc. The Commission involvement in these international frameworks is very important: as an example, it is presently chairing the Bonn Agreement Contracting Parties meeting. In addition, being the only contracting party to all these agreements, it is able to play a unique role of coordination and information to avoid duplications and contradictions. Having given this overview, I would now focus on the Community Action Plan

  4. Cooperative Regulation of the Activity of Factor Xa within Prothrombinase by Discrete Amino Acid Regions from Factor Va Heavy Chain†

    Barhoover, Melissa A.; Orban, Tivadar; Bukys, Michael A.; Kalafatis, Michael

    2008-01-01

    The prothrombinase complex catalyzes the activation of prothrombin to α-thrombin. We have repetitively shown that amino acid region 695DYDY698 from the COOH terminus of the heavy chain of factor Va regulates the rate of cleavage of prothrombin at Arg271 by prothrombinase. We have also recently demonstrated that amino acid region 334DY335 is required for the optimal activity of prothrombinase. To assess the effect of these six amino acid residues on cofactor activity, we created recombinant fa...

  5. Comparative Literature in Cooperation

    Sebastian Donat

    2008-07-01

    Full Text Available Beyond methodological or ideological principles, Comparative Literature depends upon, and flourishes in, cooperation between different systems, fields and disciplines. We introduce two projects developed by Munich’s Comparative Literature Department as examples of the specific challenges and opportunities afforded by this cooperation: in editing Roman Jakobson’s analyses of poetry, experts in 16 different languages and literatures worked together to present translations, interpretations and commentary on this corpus. In ongoing bilateral teaching and research projects with the German Department at Seoul National University, inter-lingual, inter-cultural and inter-disciplinary communication enables and informs studies focusing on Goethe’s concept of active and passive roles in Weltliteratur, as well as censorship and textual control in divided nations.

  6. IAEA research reactors activities - small research reactors, their role as first step in nuclear technology programme, and cooperation to maximize utilization

    A large number of the existing research reactors in the world are currently under utilized, in many cases because of an overly narrow assessment on the need for the research reactors at the time they were acquired, and an absence of mechanisms to ensure sustainability. On the other hand, operating and utilizing research reactor is often taken as a first step in the preparation for nuclear power program, as both the former and the latter require personnel with similar skills sets and the support of the same/similar infrastructure including regulatory body. This presentation summarizes activities conducted by member states under IAEA's Research Reactor programmes, with more focused discussion on three areas: Reduction in the use of HEU in research reactors;The role of low power critical facilities and small research reactor as a a first step in the development of nuclear energy programmes; and The need for international and regional cooperation to maximize utilization of existing research reactor facilities.

  7. The Delta Cooperative Model: a Dynamic and Innovative Team-Work Activity to Develop Research Skills in Microbiology

    Ivan Baez-Santos

    2006-12-01

    Full Text Available The Delta Cooperative Model (DCM is a dynamic and innovative teamwork design created to develop fundamentals in research skills. High school students in the DCM belong to the Upward Bound Science and Math (UBSM program at the Inter American University, Ponce Campus. After workshops on using the scientific method, students were organized into groups of three students with similar research interests. Each student had to take on a role within the group as either a researcher, data analyst, or research editor. Initially, each research team developed hypothesis-driven ideas on their proposed project. In intrateam research meetings, they emphasized team-specific tasks. Next, interteam meetings were held to present ideas and receive critical input. Finally, oral and poster research presentations were conducted at the UBSM science fair. Several team research projects covered topics in medical, environmental, and general microbiology. The three major assessment areas for the workshop and DCM included: (i student’s perception of the workshops’ effectiveness in developing skills, content, and values; (ii research team self- and group participation evaluation, and (iii oral and poster presentation during the science fair. More than 91% of the students considered the workshops effective in the presentation of scientific method fundamentals. The combination of the workshop and the DCM increased student’s knowledge by 55% from pre- to posttests. Two rubrics were designed to assess the oral presentation and poster set-up. The poster and oral presentation scores averaged 83%and 75%respectively. Finally, we present a team assessment instrument that allows the self- and group evaluation of each research team. While the DCM has educational plasticity and versatility, here we document how this model has been successfully incorporated in training and engaging students in scientific research in microbiology.

  8. The Delta Cooperative Model: a Dynamic and Innovative Team-Work Activity to Develop Research Skills in Microbiology

    Carlos Rios-Velazquez

    2009-12-01

    Full Text Available The Delta Cooperative Model (DCM is a dynamic and innovative teamwork design created to develop fundamentals in research skills. High school students in the DCM belong to the Upward Bound Science and Math (UBSM program at the Inter American University, Ponce Campus. After workshops on using the scientific method, students were organized into groups of three students with similar research interests. Each student had to take on a role within the group as either a researcher, data analyst, or research editor. Initially, each research team developed hypothesis-driven ideas on their proposed project. In intrateam research meetings, they emphasized team-specific tasks. Next, interteam meetings were held to present ideas and receive critical input. Finally, oral and poster research presentations were conducted at the UBSM science fair. Several team research projects covered topics in medical, environmental, and general microbiology. The three major assessment areas for the workshop and DCM included: (i student’s perception of the workshops’ effectiveness in developing skills, content, and values; (ii research team self- and group participation evaluation, and (iii oral and poster presentation during the science fair. More than 91% of the students considered the workshops effective in the presentation of scientific method fundamentals. The combination of the workshop and the DCM increased student’s knowledge by 55% from pre- to posttests. Two rubrics were designed to assess the oral presentation and poster set-up. The poster and oral presentation scores averaged 83%and 75%respectively. Finally, we present a team assessment instrument that allows the self- and group evaluation of each research team. While the DCM has educational plasticity and versatility, here we document how this model has been successfully incorporated in training and engaging students in scientific research in microbiology.

  9. International cooperation and coordination of activities to rehabilitate the population, ecology and economic development of Semipalatinsk region

    It is in this context that international cooperation and coordination took important steps forward in 1997 and 1998. At the last session of the United Nations General Assembly in December 1997, a Resolution was submitted with nearly 50 co-sponsors and adopted unanimously which called for an assessment to be conducted of the humanitarian effects of the nuclear testing in the Semipalatinsk region. It requested the United nations Secretary General, U N organizations and agencies, with the support of the international community, to collaborate in carrying out this assessment and to report back to the General Assembly at its next regular session which shall begin later this month in New York. This was a remarkable turning point in the global awareness about Semipalatinsk. The resolution also implicitly drew attention to the fact that Kazakstan and its populations, as victims of an extraordinary chapter of the nuclear era, should have the knowledge and the benefits that might come from an appropriate assessment of the consequences and the needs resulting from 40 years of nuclear testing, as well as the rise and fall of the Polygon. The total package of priority needs includes some $43.2 million dollars of projects: $33.7 are deemed to be relatively highest priority, but many could be effectively implemented in phases or stages and would still make a most significant contribution and impact. The breakdown is - health diagnosis, treatment and rehabilitation - $24 million; - urgent humanitarian needs - $3.3 million; - ecological stabilization and environmental protection - $7.8 million; - economic rehabilitation - $6.6 million; - information dissemination - $1.3 million

  10. Effectiveness of a mining simulation cooperative learning activity on the cognitive and affective achievement of students in a lower division physical geology course: A confluent approach

    Tolhurst, Jeffrey Wayne

    Most students enrolled in lower division physical geology courses are non-majors and tend to finish the course with little appreciation of what it is geologists really do. They may also be expected to analyze, synthesize, and apply knowledge from previous laboratory experiences with little or no instruction and/or practice in utilizing the critical thinking skills necessary to do so. This study sought to answer two research questions: (1) do physical geology students enrolled in a course designed around a mining simulation activity perform better cognitively than students who are taught the same curriculum in the traditional fashion; and (2) do students enrolled in the course gain a greater appreciation of physical geology and the work that geologists do. Eighty students enrolled in the course at Columbia College, Sonora, California over a two year period. During the first year, thirty-one students were taught the traditional physical geology curriculum. During the second year, forty-nine students were taught the traditional curriculum up until week nine, then they were taught a cooperative learning mining simulation activity for three weeks. A static group, split plot, repeated measures design was used. Pre- and post-tests were administered to students in both the control and treatment groups. The cognitive assessment instrument was validated by content area experts in the University of South Carolina Geological Sciences Department. Students were given raw lithologic, gravimetric, topographic, and environmental data with which to construct maps and perform an overlay analysis. They were tested on the cognitive reasoning and spatial analysis they used to make decisions about where to test drill for valuable metallic ores. The affective instrument used a six point Likert scale to assess students' perceived enjoyment, interest, and importance of the material. Gains scores analysis of cognitive achievement data showed a mean of 2.43 for the control group and 4.47 for

  11. Sorting and sustaining cooperation

    Vikander, Nick

    2013-01-01

    This paper looks at cooperation in teams where some people are selfish and others are conditional cooperators, and where lay-offs will occur at a fixed future date. I show that the best way to sustain cooperation prior to the lay-offs is often in a sorting equilibrium, where conditional cooperators...

  12. New Cooperative Development Issues

    Henehan, Brian M.; Hardesty, Shermain D.; Shultz, Madeline; Wells, John

    2011-01-01

    This article briefly reviews the increased interest in new cooperative development, factors for successful cooperative development, and strategies to improve the performance of new and emerging cooperatives. The article highlights issues identified by a panel of cooperative leaders, USDA specialists and academic experts

  13. TGF-β and IL-21 cooperatively stimulate activated CD8(+) T cells to differentiate into Tc17 cells.

    Chen, Hsin-Wei; Tsai, Jy-Ping; Yao, Tsung-You; Hsieh, Chia-Ling; Chen, I-Hua; Liu, Shin-Jen

    2016-06-01

    TGF-β together with IL-21 or IL-6 can drive the differentiation of naïve CD8(+) T cells into IL-17-producing CD8(+) T cells. These IL-17-producing CD8(+) T cells are termed Tc17 cells. Tc17 cells preserve plasticity under various conditions in vitro and in vivo. IFN-γ-producing CD8(+) T cells are termed Tc1 cells. However, Tc1 cells are considered relatively stable. In the present study, we show that the combination of TGF-β plus IL-21, but not IL-6, converts Tc1 cells into Tc17 cells; this conversion is associated with elevated RORα, RORγt, and Batf mRNA levels. These results indicate that Tc1 cells are skewed to the Tc17 cell phenotype under TGF-β plus IL-21-polarizing conditions. Furthermore, IL-6R is expressed on naïve, but not activated, CD8(+) T cells. In contrast, IL-21R is expressed on both naïve and activated CD8(+) T cells. Thus, differential expression profiles of IL-6R and IL-21R on naïve and activated CD8(+) T cells may be one mechanism by which TGF-β plus IL-21, but not IL-6, can drive activated CD8(+) T cells to differentiate into IL-17-producing cells. Taken together, these results provide a novel viewpoint for the plasticity of Tc1 cells. PMID:27085379

  14. The 2000 activities and the 2nd Workshop on Human Resources Development in the Nuclear Field as part of Asian regional cooperation

    NONE

    2001-06-01

    In 1999, the Project for Human Resources Development (HRD) was initiated as defined in the framework of the Forum for Nuclear Cooperation in Asia (FNCA), organized by the Atomic Energy Commission of Japan. The objective of the HRD Project is to solidify the foundation of technologies for nuclear development and utilization in Asia by promoting human resources development in Asian countries. In the Project there are two kind of activities; in-workshop activities and outside-of-workshop activities. As in-workshop activities, the 2nd Workshop on Human Resources Development in the Nuclear Field was held on November 27 and 28, 2000, at the Tokai Research Institute of JAERI. As outside-of-workshop activities. 'The presentation of the present state of international training and education in the nuclear field in Japan' was held on November 29, 2000 after the workshop. Participating countries were China, Indonesia, South Korea, Japan, Malaysia, the Philippines, Thailand, and Vietnam. The secretariat for the Human Resources Development Projects is provided by the Nuclear Technology and Education Center of the Japan Atomic Energy Research Institute. This report consists of presentation papers and materials at the Workshop, presentation documents of 'The present state of international training and education in the nuclear field in Japan', a letter of proposal from the Project Leader of Japan to the project leaders of the participating countries after the Workshop and a presentation paper on Human Resources Development at the 3rd Coordinators Meeting of FNCA at Tokyo on March 14-16, 2001. (author)

  15. Sleeping Beauty transposon screen identifies signaling modules that cooperate with STAT5 activation to induce B-cell acute lymphoblastic leukemia.

    Heltemes-Harris, L M; Larson, J D; Starr, T K; Hubbard, G K; Sarver, A L; Largaespada, D A; Farrar, M A

    2016-06-30

    Signal transducer and activator of transcription 5 (STAT5) activation occurs frequently in human progenitor B-cell acute lymphoblastic leukemia (B-ALL). To identify gene alterations that cooperate with STAT5 activation to initiate leukemia, we crossed mice expressing a constitutively active form of STAT5 (Stat5b-CA) with mice in which a mutagenic Sleeping Beauty transposon (T2/Onc) was mobilized only in B cells. Stat5b-CA mice typically do not develop B-ALL (<2% penetrance); in contrast, 89% of Stat5b-CA mice in which the T2/Onc transposon had been mobilized died of B-ALL by 3 months of age. High-throughput sequencing approaches were used to identify genes frequently targeted by the T2/Onc transposon; these included Sos1 (74%), Kdm2a (35%), Jak1 (26%), Bmi1 (19%), Prdm14 or Ncoa2 (13%), Cdkn2a (10%), Ikzf1 (8%), Caap1 (6%) and Klf3 (6%). Collectively, these mutations target three major cellular processes: (i) the Janus kinase/STAT5 pathway (ii) progenitor B-cell differentiation and (iii) the CDKN2A tumor-suppressor pathway. Transposon insertions typically resulted in altered expression of these genes, as well as downstream pathways including STAT5, extracellular signal-regulated kinase (Erk) and p38. Importantly, expression of Sos1 and Kdm2a, and activation of p38, correlated with survival, further underscoring the role these genes and associated pathways have in B-ALL. PMID:26500062

  16. Cooperative activation of transcription by bovine papillomavirus type 1 E2 can occur over a large distance.

    Thierry, F; Dostatni, N; Arnos, F; Yaniv, M

    1990-01-01

    The viral transcriptional factors encoded by the E2 open reading frame bind to the specific DNA sequence elements ACCGNNNNCGGT, allowing activation or repression of transcription. We have analyzed bovine papillomavirus type 1 E2 transactivation using recombinant genes containing E2-binding sites inserted at either 3' or 5' positions relative to the heterologous transcriptional initiation site of the herpes simplex virus thymidine kinase gene. In these hybrid plasmids, strong transactivation r...

  17. Supply and Marketing Cooperatives

    2008-01-01

    @@ China Supply and Marketing Cooperatives Council of CCPIT was established in March 1996. It is an institution under direct leadership of China Supply and Market-ing Cooperatives and at the same time a branch of China Council for Promotion of International Trade, with its major task to promoting and facilitating export-oriented economic trade and technological cooper-ation of the national supply and marketing cooperative system.

  18. Cooperation within physician–nurse team in occupational medicine service in Poland – Knowledge about professional activities performed by the team-partner

    Piotr Sakowski

    2015-10-01

    Full Text Available Background: The goal of the study has been to learn about physicians’ and nurses’ awareness of the professional activities that are being performed by their colleague in the physician–nurse team. Material and Methods: Postal questionnaires were sent out to occupational physicians and nurses in Poland. The analysis includes responses from 232 pairs of physician–nurse teams. Results: The knowledge among occupational professionals about tasks performed by their colleagues in the physician–nurse team seems to be poor. Respondents were asked about who performs tasks from each of 21 groups mentioned in the Occupational Medicine Service Act. In the case of only 3 out of 21 groups of tasks, the rate of non-consistence in answers was lower than 30%. A specified number of professionals performed their tasks on the individual basis. Although in many cases their team colleagues knew about those activities, there was a major proportion of those who had no awareness of such actions. Conclusions: Polish occupational physicians and nurses perform a variety of tasks. Occupational nurses, besides medical role, also play important organizational roles in their units. The cooperation between the two professional groups is, however, slightly disturbed by the deficits in communication. This issue needs to be improved for the betterment of operations within the whole system. Med Pr 2015;66(5:625–633

  19. Biodegradation of 4-chloronitrobenzene by biochemical cooperation between Sphingomonas sp. strain CNB3 and Burkholderia sp. strain CAN6 isolated from activated sludge.

    Zhang, Longjiang; Wang, Xin; Jiao, Yiying; Chen, Xu; Zhou, Lingyan; Guo, Kun; Ge, Feng; Wu, Jun

    2013-05-01

    Two bacterial strains were isolated from activated sludge by using 4-chloronitrobenzene (4-CB) as the sole source of carbon for enrichment. One of the isolates was identified as Sphingomonas sp. strain CNB3 and the other as Burkholderia sp. strain CAN6, mainly through morphological and physiological characteristics and 16S rRNA gene sequence analysis. Sphingomonas sp. strain CNB3 could transform 4-CB to 4-chloroaniline, which accumulated in the medium. Burkholderia sp. strain CAN6 could transform 4-chloroaniline but not 4-CB. The co-culture of Sphingomonas sp. strain CNB3 and Burkholderia sp. strain CAN6 could degrade 4-CB completely by the biochemical cooperation of two strains to overcome the degradative limitations of each species alone. In addition, the biochemical pathway of 4-chloroaniline transformation by Burkholderia sp. strain CAN6 was proposed based on the determined related enzyme activities. The results suggested that 4-chloroaniline was completely transformed via the ortho-cleavage and modified ortho-cleavage pathways. PMID:23473429

  20. Papain-templated Cu nanoclusters: assaying and exhibiting dramatic antibacterial activity cooperating with H2O2

    Miao, Hong; Zhong, Dan; Zhou, Zinan; Yang, Xiaoming

    2015-11-01

    Herein, papain-functionalized Cu nanoclusters (CuNCs@Papain) were originally synthesized in aqueous solution together with a quantum yield of 14.3%, and showed obviously red fluorescence at 620 nm. Meanwhile, their corresponding fluorescence mechanism was fully elucidated by fluorescence spectroscopy, HR-TEM, FTIR spectroscopy, and XPS. Subsequently, the as-prepared CuNCs were employed as probes for detecting H2O2. Using CuNCs as probes, H2O2 was determined in the range from 1 μM to 50 μM based on a linear decrease of fluorescence intensity as well as a detection limit of 0.2 μM with a signal-to-noise ratio of 3. More significantly, it has been proved that CuNCs could convert H2O2 to &z.rad;OH, which exhibited dramatic antibacterial activity. Both in vitro and in vivo experiments were performed to validate their antibacterial activity against Gram-positive/negative bacteria and actual wound infection, suggesting their potential for serving as one type of promising antibacterial material.Herein, papain-functionalized Cu nanoclusters (CuNCs@Papain) were originally synthesized in aqueous solution together with a quantum yield of 14.3%, and showed obviously red fluorescence at 620 nm. Meanwhile, their corresponding fluorescence mechanism was fully elucidated by fluorescence spectroscopy, HR-TEM, FTIR spectroscopy, and XPS. Subsequently, the as-prepared CuNCs were employed as probes for detecting H2O2. Using CuNCs as probes, H2O2 was determined in the range from 1 μM to 50 μM based on a linear decrease of fluorescence intensity as well as a detection limit of 0.2 μM with a signal-to-noise ratio of 3. More significantly, it has been proved that CuNCs could convert H2O2 to &z.rad;OH, which exhibited dramatic antibacterial activity. Both in vitro and in vivo experiments were performed to validate their antibacterial activity against Gram-positive/negative bacteria and actual wound infection, suggesting their potential for serving as one type of promising

  1. New and recently finalised activities within the NKS Programmes for Nordic cooperation on nuclear reactor safety and emergency preparedness

    Andgren, Karin; Andersson, Kasper Grann; Magnússon, Sigurður M.;

    2015-01-01

    Over the years, NKS has provided funding for hundreds of research activities in fields comprising reactor safety, decommissioning, nuclear and radiological emergency preparedness, and management of radioactive waste. Advanced technologies and methods developed under the NKS framework have been used...... within the Nordic countries as well as internationally. Two programme areas are defined under the NKS platform: The NKS-R programme on nuclear reactor safety and the NKS-B programme on emergency preparedness. Three articles, giving an introduction to NKS and its two programmes, were published in...

  2. Telemedical work and cooperation.

    Aas, I H

    2001-01-01

    In telemedicine, cooperation occurs via telecommunication. This represents a new situation for medical cooperation. Whether such cooperation works poorly or well will be important with an increasing volume of telemedicine. When personnel are involved in external cooperation, as in telemedicine, the question of cooperation within one's own organization also arises. To investigate these matters, qualitative interviews were performed with 30 persons working in teledermatology, telepsychiatry, a telepathology frozen-section service and tele-otolaryngology. The results showed that cooperating by telecommunication mainly worked well. The cooperation may be influenced by factors such as personality, knowing each other personally, preparation and experience. Telemedical teamwork may be improved by factors like experience and education. Working with telemedicine did not reduce the personnel's cooperation within their own organizations, but rather improved it, although this effect was slight and most commonly involved improved knowledge of others. In general, the findings concerning cooperation and telemedicine were positive. PMID:11506756

  3. Cooperativity between Al Sites Promotes Hydrogen Transfer and Carbon-Carbon Bond Formation upon Dimethyl Ether Activation on Alumina.

    Comas-Vives, Aleix; Valla, Maxence; Copéret, Christophe; Sautet, Philippe

    2015-09-23

    The methanol-to-olefin (MTO) process allows the conversion of methanol/dimethyl ether into olefins on acidic zeolites via the so-called hydrocarbon pool mechanism. However, the site and mechanism of formation of the first carbon-carbon bond are still a matter of debate. Here, we show that the Lewis acidic Al sites on the 110 facet of γ-Al2O3 can readily activate dimethyl ether to yield CH4, alkenes, and surface formate species according to spectroscopic studies combined with a computational approach. The carbon-carbon forming step as well as the formation of methane and surface formate involves a transient oxonium ion intermediate, generated by a hydrogen transfer between surface methoxy species and coordinated methanol on adjacent Al sites. These results indicate that extra framework Al centers in acidic zeolites, which are associated with alumina, can play a key role in the formation of the first carbon-carbon bond, the initiation step of the industrial MTO process. PMID:27162986

  4. Overview of the burnup credit activities of the Organization for Economic Cooperation and Development/Nuclear Energy Agency (OECD/NEA)

    This article summarises activities of the Organization for Economic Cooperation and Development/Nuclear Energy Agency (OECD/NEA) Expert Group on Burnup Credit Criticality, a subordinate group to the Working Part on Nuclear Criticality Safety (WPNCS). The WPNCS of the OECD/NEA coordinates and carries out work in the domain of criticality safety at the international level. Particular attention is devoted to establishing sound databases required in this area and to addressing issues of high relevance such as burnup credit. The activities of the expert group are aimed toward improving safety and identifying economic solutions to issues concerning the back-end of the fuel cycle. The main objective of the activities of the OECD/NEA Expert Group on Burnup Credit Criticality is to demonstrate that the available criticality safety calculational tools are appropriate for application to irradiated (burned) nuclear fuel systems and that a reasonable safety margin can be established. The method established by the expert group for investigating the physics and predictability of burnup credit is based on the specification and comparison of calculational benchmark problems. A wide range of fuel types, including PWR, BWR, MOX, and VVER fuels, has been or is being addressed by the expert group. The objective and status of each of these benchmark problems is reviewed in this article. It is important to note that the focus of the expert group is the comparison of the results submitted by each participant to assess the capability of commonly used code systems, not to quantify the physical phenomena investigated in the comparisons or to make recommendations for licensing action. (author)

  5. THE ACTIVITIES OF THE STATE APPARATUS OF THE RUSSIAN FEDERATION IN THE SPHERE OF DEVELOPMENT OF MILITARY COOPERATION WITHIN THE COLLECTIVE SECURITY TREATY ORGANIZATION

    Sergey Mikhailovich Gontar

    2015-01-01

    Full Text Available In the conditions existing on the territory of post-Soviet realities, solution of the task of ensuring independence, territorial integrity and sovereignty is impossible without the adequate security component. The Collective Security Treaty was signed on May 15, 1992 within the frame of the CIS to join the armed forces of the State parties, which were integral parts of the military potential of the Soviet Union. Having inherited the major part of military units and military infrastructure of the former Soviet Union, Russia had a significant impact on the development of military cooperation of the Collective Security Treaty Organization (CSTO.The author gives the definition of military cooperation of the CSTO, highlights its main components and the necessity of their development, the order of the development of the main directions in military cooperation, the role of the Russian leadership in their formation.The study characterizes the work of the State apparatus of the Russian Federation carried out for the development of military cooperation of the CSTO, notes the main difficulties arising in the process of formation and development of the main directions of military cooperation. The study indicates the influence of the foreign policies of the CSTO member-states on the intensity of military cooperation. The conclusion highlights the role and place of military cooperation as one of the directions in interaction between the CSTO member-countries, the work of the State apparatus of the Russian Federation on its development, and outlines the main directions of further development.

  6. To cooperate or not to cooperate

    Wessels, Josepha Ivanka

    To Cooperate or not to Cooperate...? discusses results of a research project to study the rehabilitation of 1500-year old water tunnels, so called "qanats", in Syria. Communities all over the world are using traditional technologies to extract drinkingwater, irrigate their lands and feed their...

  7. Designing for cooperation - cooperating in design

    Kyng, Morten

    1991-01-01

    This article will discuss how to design computer applications that enhance the quality of work and products, and will relate the discussion to current themes in the field of Computer-Supported Cooperative Work (CSCW). Cooperation is a key element of computer use and work practice, yet here a...

  8. Activated tumor cell integrin αvβ3 cooperates with platelets to promote extravasation and metastasis from the blood stream.

    Weber, Martin R; Zuka, Masahiko; Lorger, Mihaela; Tschan, Mario; Torbett, Bruce E; Zijlstra, Andries; Quigley, James P; Staflin, Karin; Eliceiri, Brian P; Krueger, Joseph S; Marchese, Patrizia; Ruggeri, Zaverio M; Felding, Brunhilde H

    2016-04-01

    Metastasis is the main cause of death in cancer patients, and understanding mechanisms that control tumor cell dissemination may lead to improved therapy. Tumor cell adhesion receptors contribute to cancer spreading. We noted earlier that tumor cells can expressing the adhesion receptor integrin αvβ3 in distinct states of activation, and found that cells which metastasize from the blood stream express it in a constitutively high affinity form. Here, we analyzed steps of the metastatic cascade in vivo and asked, when and how the affinity state of integrin αvβ3 confers a critical advantage to cancer spreading. Following tumor cells by real time PCR, non-invasive bioluminescence imaging, intravital microscopy and histology allowed us to identify tumor cell extravasation from the blood stream as a rate-limiting step supported by high affinity αvβ3. Successful transendothelial migration depended on cooperation between tumor cells and platelets involving the high affinity tumor cell integrin and release of platelet granules. Thus, this study identifies the high affinity conformer of integrin αvβ3 and its interaction with platelets as critical for early steps during hematogenous metastasis and target for prevention of metastatic disease. PMID:27067975

  9. Cooperative cytotoxic activity of Zn and Cu in bovine serum albumin-conjugated ZnS/CuS nano-composites in PC12 cancer cells

    Series of self-assembled and mono-dispersed bovine serum albumin (BSA)-conjugated ZnS/CuS nano-composites with different Zn/Cu ratios had been successfully synthesized by a combination method of the biomimetic synthesis and ion-exchange strategy under the gentle conditions. High-resolution transmission electron microscopy observation, Fourier transform infrared spectra and zeta potential analysis demonstrated that BSA-conjugated ZnS/CuS nano-composites with well dispersity had the hierarchical structure and BSA was a key factor to control the morphology and surface electro-negativity of final products. The real-time monitoring by atomic absorption spectroscopy and powder X-ray diffraction revealed that the Zn/Cu ratio of nano-composites could be controlled by adjusting the ion-exchange time. In addition, the metabolic and morphological assays indicated that the metabolic proliferation and spread of rat pheochromocytoma (PC12) cells could be inhibited by nano-composites, with the high anti-cancer activity at a low concentration (4 ppm). What were more important, Zn and Cu in nano-composites exhibited a positive cooperativity at inhibiting cancer cell functions. The microscope observation and biochemical marker analysis clearly revealed that the nano-composites-included lipid peroxidation and disintegration of membrane led to the death of PC12 cells. Summarily, the present study substantiated the potential of BSA-conjugated ZnS/CuS nano-composites as anti-cancer drug

  10. Strategy of International Economic Cooperation: methodological aspects

    Maximilian Silvestru

    2013-01-01

    Full Text Available In the present article, the authors describe the essence of cooperation and those strategic problems that can be solved internationally only through cooperation efforts. In this context, the authors propose to understand cooperation as the actions of a few companies, corporations from one country or several countries that through their activities contribute to the achievement of goals of economic, ecological and social importance for a region, a country, many countries or for all humanity. Cooperation in such cases, contribute to realization of synergistic results and development of preconditions for each participant to carry out its activities according to its own optimization criteria. Cooperation generates productive systems based on principles and technologies, it can be multispectral, creates preconditions for demand increasing, solves some marketing problems, creates a comfortable space for the activities of all economic subjects.

  11. STRATEGY OF INTERNATIONAL ECONOMIC COOPERATION: METHODOLOGICAL ASPECTS

    Aliona DANILIUC

    2013-01-01

    Full Text Available In the present article, the authors describe the essence of cooperation and those strategic problems that can be solved internationally only through cooperation efforts. In this context, the authors propose to understand cooperation as the actions of a few companies, corporations from one country or several countries that through their activities contribute to the achievement of goals of economic, ecological and social importance for a region, a country, many countries or for all humanity. Cooperation in such cases, contribute to realization of synergistic results and development of preconditions for each participant to carry out its activities according to its own optimization criteria. Cooperation generates productive systems based on principles and technologies, it can be multispectral, creates preconditions for demand increasing, solves some marketing problems, creates a comfortable space for the activities of all economic subjects.

  12. Cooperative Tagging Center (CTC)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Cooperative Tagging Center (CTC) began as the Cooperative Game Fish Tagging Program (GTP) at Woods Hole Oceanographic Institute (WHOI) in 1954. The GTP was...

  13. Success and failure of firms' innovation co-operations: The role of intermediaries and reciprocity

    Cantner, U.; Meder, A.; Wolf, T.

    2011-01-01

    There is manifold literature dealing with co-operative activities of firms. However, no empirical study seems to have investigated the factors leading to malfunctions in co-operation projects in terms of a low likelihood of co-operation, low rate of success, and failed co-operation. Our paper att...... main determinant of failed co-operation projects....

  14. Cooperative Online Education

    Morten Flate Paulsen

    2008-01-01

    Cooperative learning seeks to develop virtual learning environments that allow students to have optimal individual freedom within online learning communities. The pedagogical and administrative challenges with regard to accommodating both individual freedom and cooperation are explained in the Theory of Cooperative Freedom. This article shows that cooperative learning can be implemented successfully through a set of instruments or means. To illustrate this with current examples, the article p...

  15. The Cooperative Brain

    Stallen, M.; Sanfey, A.G.

    2013-01-01

    Cooperation is essential for the functioning of human societies. To better understand how cooperation both succeeds and fails, recent research in cognitive neuroscience has begun to explore novel paradigms to examine how cooperative mechanisms may be encoded in the brain. By combining functional neu

  16. Precompetitive cooperative research

    This paper reports that in the current worldwide technology environment, it is essential for the U.S. microelectronics industry, and especially for the integrated circuit portion of that industry, that precompetitive cooperative research alliances be formed and funded at a level that enables them to be effective in rapidly advancing technology. It is important to realize that technology advances with or without our direct participation. If we do not aggressively participate we are quickly left behind. Increasing complexity and miniaturization have been the themes in semiconductor technology. Many are aware that what began in the early 60's with a few masking steps and minimum dimensions measured in mils, has now evolved to a level of sophistication requiring a 100 MIP workstation for IC design and the investment of nearly $400 million dollars in fab cost to produce today's microchips. The leading nations of the world have come to realize that their future well- being is closely tied to their ability to compete in this hi- tech environment. Industry coalitions have been formed to exploit the early ramifications of emerging technologies. Improvements in overseas manufacturing have been made and continue unabated with new products, new processes, and new services being introduced at an increasing rate. Many foreign governments are now actively involved in formulating and conducting industrial and technology policies to aid their hi-tech industry. To meet these challenges, U.S. firms, with U.S. government cooperation, must respond

  17. International Business: cooperation within networks

    van Delft, Anne

    2011-01-01

    Internationalisation is the expansion of a firms operations to foreign markets and includes not only import and export but also foreign direct investments and international cooperation. Today’s globalising economy has resulted in a growing number of small and medium enterprises (SMEs) undertaking international activities. Internationalisation has been shown to be very beneficial for firms. Cross-border activities are an important means through which SMEs are able to create value, generate gro...

  18. International cooperation workshop. Regional workshop for CTBTO international cooperation: Africa

    Pursuant to the 1999 programme of work, and following the International Cooperation Workshop held in Vienna, Austria, in 1998, the Provisional Technical Secretariat (PTS) of the Preparatory Commission for the CTBTO (Prep Com) held a regional Workshop for CTBTO International Cooperation in Cairo. The purpose of the workshop was to identify how and by what means the Africa region can promote international cooperation in CTBT verification related technologies, and how the region can benefit from and contribute to Prep Com activity. PTS staff briefed the 40 participants from 22 African States who attended the Workshop on general aspects, including costs, of the establishment and operation of the CTBT verification system, including its four monitoring technologies. Participants were informed on opportunities for local institutions in the establishment of monitoring stations and on possible support for national and regional data centres. National experts presented their research and development activities and reviewed existing experiences on bi/multi-lateral cooperation. The main points of the discussion focused on the need to engage governments to advance signature/ratification, and further training opportunities for African states

  19. Reactions of [Cu(X)(BPEP-Ph)] (X = PF6, SbF6) with silyl compounds. Cooperative bond activation involving non-coordinating anions.

    Nakajima, Yumiko; Tsuchimoto, Takahiro; Chang, Yung-Hung; Takeuchi, Katsuhiko; Ozawa, Fumiyuki

    2016-02-01

    Bond activation of silyl compounds, assisted by the cooperative action of non-coordinating anions, is achieved using Cu(I) complexes coordinated with a PNP-pincer type phosphaalkene ligand, [Cu(X)(BPEP-Ph)] (X = PF6 (1a), SbF6 (1b); BPEP-Ph = 2,6-bis[1-phenyl-2-(2,4,6-tri-tert-butylphenyl)-2-phosphaethenyl]pyridine). Complexes 1a and 1b react with Me3SiCN to form Me3SiF and Cu(i) cyanide complexes of the formula [Cu(CN-EF5)(BPEP-Ph)] (E = P (2a), Sb (2b)), in which the CN ligand is associated with the EF5 group arising from EF6(-). Formation of the intermediary isonitrile complex [Cu(CNSiMe3)(BPEP-Ph)](+)SbF6(-) (3b) is confirmed by its isolation. Thus, a two-step reaction process involving coordination of Me3SiCN, followed by nucleophilic attack of SbF6(-) on the silicon atom of 3b is established for the conversion of 1b to 2b. Complex 1b cleaves the H-Si bond of PhMe2SiH as well. The isolation and structural identification of [Cu(BPEP-Ph)](+)BAr(F)4(-) (1c) (BAr(F)4 = B{3,5-(CF3)2C6H3}4) as a rare example of a T-shaped, three-coordinated Cu(i) complex is reported. PMID:26455594

  20. Telomerase Reverse Transcriptase and Peroxisome Proliferator-Activated Receptor γ Co-Activator-1α Cooperate to Protect Cells from DNA Damage and Mitochondrial Dysfunction in Vascular Senescence.

    Mendelsohn, Andrew R; Larrick, James W

    2015-10-01

    Reduced telomere length with increasing age in dividing cells has been implicated in contributing to the pathologies of human aging, which include cardiovascular and metabolic disorders, through induction of cellular senescence. Telomere shortening results from the absence of telomerase, an enzyme required to maintain telomere length. Telomerase reverse transcriptase (TERT), the protein subunit of telomerase, is expressed only transiently in a subset of adult somatic cells, which include stem cells and smooth muscle cells. A recent report from Xiong and colleagues demonstrates a pivotal role for the transcription co-factor peroxisome proliferator-activated receptor γ co-activator-1α (PGC-1α) in maintaining TERT expression and preventing vascular senescence and atherosclerosis in mice. Ablation of PGC-1α reduced TERT expression and increased DNA damage and reactive oxygen species (ROS), resulting in shortened telomeres and vascular senescence. In the ApoE(-/-) mouse model of atherosclerosis, forced expression of PGC-1α increased expression of TERT, extended telomeres, and reversed genomic DNA damage, vascular senescence, and the development of atherosclerotic plaques. Alpha lipoic acid (ALA) stimulated expression of PGC-1α and TERT and reversed DNA damage, vascular senescence, and atherosclerosis, similarly to ectopic expression of PGC-1α. ALA stimulated cyclic adenosine monophosphate (cAMP) signaling, which in turn activated the cAMP response element-binding protein (CREB), a co-factor for PGC-1α expression. The possibility that ALA might induce TERT to extend telomeres in human cells suggests that ALA may be useful in treating atherosclerosis and other aging-related diseases. However, further investigation is needed to identify whether ALA induces TERT in human cells, which cell types are susceptible, and whether such changes have clinical significance. PMID:26414604

  1. Japanese activities for the safety and security of radiation sources within the framework of the Forum for Nuclear Cooperation in Asia

    The Forum for Nuclear Cooperation in Asia was organized subsequent to the International Conference for Nuclear Cooperation in Asia in 1999. Nine countries - Australia, China, Indonesia, Japan, Republic of Korea, Malaysia, Philippines, Thailand and Viet Nam - are participating, with the aim of exchanging views and information on the fields of: (1) utilization of research reactors, (2) utilization of radioisotopes and radiation in agriculture, (3) application of radioisotopes and radiation in medicine, (4) public information on nuclear energy, (5) radioactive waste management (RWM), (6) safety culture of nuclear energy, and (7) human resources development and new projects. A task group on management of spent radiation sources was established in the RWM project in 2001. Four discussion/survey meetings were held, with fruitful results. One of the most important points was that this kind of 'horizontal' cooperation would not only foster mutual understanding but could also guide the preparation of a regulatory system and management system. (author)

  2. The Application of Cooperative Learning in EFL Teaching

    李晓花; 龙萍

    2012-01-01

    Cooperative learning can not only fully activate the students' initiative and enthusiasm in learning,but also can cultivate the creative awareness and ability of the students.Based on the characteristics and positive effects of cooperative learning,this thesis has made an attentive discussion of the problems existed in the application of cooperative learning in EFL teaching process.Furthermore,countermeasures have been proposed to enhance the valid implementation of cooperative learning in teaching.

  3. The role of configurational entropy in biochemical cooperativity.

    Jusuf, Sutjano; Loll, Patrick J; Axelsen, Paul H

    2002-04-10

    Cooperativity is a common biochemical phenomenon in which two or more otherwise independent processes are thermodynamically coupled. Because cooperative processes are usually attended by changes in molecular conformation, thermodynamic coupling is usually attributed to an enthalpy-driven mechanism. In the family of glycopeptide antibiotics that includes vancomycin, however, cooperative phenomena occur that cannot be explained by conformational change. In this communication, we demonstrate that cooperativity in these systems can arise solely from changes in vibrational activity. PMID:11929222

  4. P-wave Cooper pair splitting

    Henning Soller

    2012-07-01

    Full Text Available Background: Splitting of Cooper pairs has recently been realized experimentally for s-wave Cooper pairs. A split Cooper pair represents an entangled two-electron pair state, which has possible application in on-chip quantum computation. Likewise the spin-activity of interfaces in nanoscale tunnel junctions has been investigated theoretically and experimentally in recent years. However, the possible implications of spin-active interfaces in Cooper pair splitters so far have not been investigated.Results: We analyze the current and the cross correlation of currents in a superconductor–ferromagnet beam splitter, including spin-active scattering. Using the Hamiltonian formalism, we calculate the cumulant-generating function of charge transfer. As a first step, we discuss characteristics of the conductance for crossed Andreev reflection in superconductor–ferromagnet beam splitters with s-wave and p-wave superconductors and no spin-active scattering. In a second step, we consider spin-active scattering and show how to realize p-wave splitting using only an s-wave superconductor, through the process of spin-flipped crossed Andreev reflection. We present results for the conductance and cross correlations.Conclusion: Spin-activity of interfaces in Cooper pair splitters allows for new features in ordinary s-wave Cooper pair splitters, that can otherwise only be realized by using p-wave superconductors. In particular, it provides access to Bell states that are different from the typical spin singlet state.

  5. Cooperative Cognitive Systems

    Giupponi, Lorenza; Ibars, Christian

    2009-01-01

    In this chapter, we have described how cooperation can benefit the different phases of the so called cognitive radio cycle. In particular we have focused on physical layer cooperation, showing that benefits can be obtained for both the primary and the secondary system in terms of spatial diversity, increased range and increased availability. In addition, we have modeled the critical interference management problem in a cooperative and cognitive system through a game theoretical approach, as w...

  6. Cooperative Machine Learning Method

    Adnan M. Al-Khatib

    2011-01-01

    Cooperative learning refers to an approach where one or more team of learners work together towards reaching a better knowledge or understanding of a specified task. The purpose of this paper is to use this approach to describe a proposal for designing and building a cooperative machine learning system (Multi-Learning system) that contains two or more machine learners that cooperate together. The objective of the proposal in this paper is to improve the effectiveness of the machine learning...

  7. Cooperative wireless communications

    Zhang, Yan

    2009-01-01

    Cooperative devices and mechanisms are increasingly important to enhance the performance of wireless communications and networks, with their ability to decrease power consumption and packet loss rate and increase system capacity, computation, and network resilience. Considering the wide range of applications, strategies, and benefits associated with cooperative wireless communications, researchers and product developers need a succinct understanding of relevant theory, fundamentals, and techniques to navigate this challenging field. ""Cooperative Wireless Communications"" provides just that. I

  8. Action to Combat Intolerance and Xenophobia in the Activities of the Council of Europe's Council for Cultural Co-operation, 1969-1989.

    Perotti, Antonio

    This report surveys the steps taken by the Council of Europe's Council for Cultural Cooperation (CDCC) to combat the increasing problem of intolerance and xenophobia in Western Europe. The outbreak of xenophobic sentiment is attributed to two facts: large immigrant communities from outside Europe have settled permanently in Europe, and there has…

  9. PROSPECTS FOR AGRICULTURAL COOPERATIVES IN ROMANIA IN THE CONTEXT OF CAP REFORM 2014-2020

    Turek Rahoveanu, Maria Magdalena; Adrian TUREK RAHOVEANU; Luiza CRISTEA

    2012-01-01

    European and global cooperative sector is a powerful economic and social actors within these societies, with significant results can be summarized as market shares both in their work and contribution to GDP and the number of members and the welfare of citizens offered through job creation. Global cooperative activity operates on cooperative principles cooperative companies regularly reviewed by members of the International Cooperative Alliance (ICA). This cooperative movement worldwide organi...

  10. Cooperative Station History Forms

    National Oceanic and Atmospheric Administration, Department of Commerce — Various forms, photographs and correspondence documenting the history of Cooperative station instrumentation, location changes, inspections, and...

  11. Synthetic Yeast Cooperation

    Shou, Wenying; Burton, Justin

    2010-03-01

    Cooperation is wide-spread and has been postulated to drive major transitions in evolution. However, Darwinian selection favors ``cheaters'' that consume benefits without paying a fair cost. How did cooperation evolve against the threat of cheaters? To investigate the evolutionary trajectories of cooperation, we created a genetically tractable system that can be observed as it evolves from inception. The system consists of two engineered yeast strains -- a red-fluorescent strain that requires adenine and releases lysine and a yellow-fluorescent strain that requires lysine and releases adenine. Cells that consume but not supply metabolites would be cheaters. From the properties of two cooperating strains, we calculated and experimentally verified the minimal initial cell densities required for the viability of the cooperative system in the absence of exogenously added adenine and lysine. Strikingly, evolved cooperative systems were viable at 100-fold lower initial cell densities than their ancestors. We are investigating the nature and diversity of pro-cooperation changes, the dynamics of cooperator-cheater cocultures, and the effects of spatial environment on cooperation and cheating.

  12. Fifty years of Technical Cooperation

    The International Atomic Energy Agency (IAEA) was established in Vienna in 1957. The Statute of the IAEA, approved by 81 nations, founded the organization on three pillars: nuclear verification; safety and security; and the transfer of technology. Today, these three pillars still remain at the heart of the organization's work. However, the way in which the IAEA carries out this work, particularly with regard to technology transfer, has changed greatly over the years. When the IAEA opened for business, nuclear science and technology were in their infancy. Many Member States had no nuclear capacity at all. The IAEA's 'technical assistance' programme, as it was then known, was modest. Early projects were small in scale and short lived, focusing mainly on building human capacities and creating institutions and facilities that would support the introduction of nuclear technology in a safe and effective manner. Today, the picture is more complex. Instead of merely offering assistance, the IAEA focuses on cooperation for sustainable socioeconomic development, building on the skills and infrastructure that Member States have acquired over the past five decades. Member States are full partners in the process, guiding the IAEA's technical cooperation activities, setting national and regional priorities, and offering training opportunities and technical support to the IAEA and to other Member States. Technical cooperation between developing countries is facilitated and supported through regional cooperative agreements. Regional centres of expertise play an important role in sharing the benefits of nuclear science and technology among Member States

  13. Cooperation, Motivation and Social Balance

    Bosworth, Steven J.; Singer, Tania; Snower, Dennis J.

    2016-01-01

    This paper examines the reflexive interplay between individual decisions and social forces to analyze the evolution of cooperation in the presence of "multi-directedness," whereby people's preferences depend on their psychological motives. People have access to multiple, discrete motives. Different motives may be activated by different social settings. Inter-individual differences in dispositional types affect the responsiveness of people's motives to their social settings. The evolution of t...

  14. Cooperation, Motivation and Social Balance

    Bosworth, Steven J.; Singer, Tania; Snower, Dennis J.

    2016-01-01

    This paper examines the reflexive interplay between individual decisions and social forces to analyze the evolution of cooperation in the presence of "multi-directedness", whereby people's preferences depend on their psychological motives. People have access to multiple, discrete motives. Different motives may be activated by different social settings. Inter-individual differences in dispositional types affect the responsiveness of people's motives to their social settings. The evolution of t...

  15. Coordination and Cooperation

    Janssen, Maarten

    2003-01-01

    textabstractThis comment makes four related points. First, explaining coordination is different from explaining cooperation. Second, solving the coordination problem is more important for the theory of games than solving the cooperation problem. Third, a version of the Principle of Coordination can be rationalized on individualistic grounds. Finally, psychological game theory should consider how players perceive their gaming situation. ---------------------------------------------------------...

  16. Making Cooperative Learning Powerful

    Slavin, Robert E.

    2014-01-01

    Just about everyone loves the "idea" of cooperative learning, children working productively and excitedly in groups, everyone getting along and enthusiastically helping one another learn. This article presents five strategies that teachers can use to get the greatest benefit possible from cooperative learning and ensure that…

  17. Scandinavian Cooperative Advantage

    Strand, Robert; Freeman, R. Edward

    2015-01-01

    . We conclude by endorsing the expression “Scandinavian cooperative advantage” in an effort to draw attention to the Scandinavian context and encourage the field of strategic management to shift its focus from achieving a competitive advantage toward achieving a cooperative advantage....

  18. Non-cooperative Games

    van Damme, E.E.C.

    2000-01-01

    Non-cooperative games are mathematical models of interactive strategic decision situations.In contrast to cooperative models, they build on the assumption that all possibilities for commitment and contract have been incorporated in the rules of the game.This contribution describes the main models (g

  19. Cooperation or Silent Rivalry?

    Zank, Wolfgang

    2010-01-01

    on an increasingly institutionalized basis. In terms of military cooperation the US is still the partner for Egypt. But outside the military sphere institutionalized cooperation is comparatively week. In particular the failure of the US to conclude a free-trade agreement has been crucial. But it...

  20. Efficiency in Microfinance Cooperatives

    HARTARSKA, Valentina

    2012-12-01

    Full Text Available In recognition of cooperatives’ contribution to the socio-economic well-being of their participants, the United Nations has declared 2012 as the International Year of Cooperatives. Microfinance cooperatives make a large part of the microfinance industry. We study efficiency of microfinance cooperatives and provide estimates of the optimal size of such organizations. We employ the classical efficiency analysis consisting of estimating a system of equations and identify the optimal size of microfinance cooperatives in terms of their number of clients (outreach efficiency, as well as dollar value of lending and deposits (sustainability. We find that microfinance cooperatives have increasing returns to scale which means that the vast majority can lower cost if they become larger. We calculate that the optimal size is around $100 million in lending and half of that in deposits. We find less robust estimates in terms of reaching many clients with a range from 40,000 to 180,000 borrowers.

  1. An fMRI study of joint action – varying levels of cooperation correlates with activity in sensorimotor control, but not mentalization, networks

    Thierry Chaminade; Marchant, Jennifer L.; James Kilner; Frith, Christopher D

    2012-01-01

    As social agents, humans continuously interact with with the people around them. Here, motor cooperation was investigated by designing a situation in which pairs of participants, one being scanned with fMRI, controlled jointly a visually presented object with joystick movements. The object oscillated dynamically along two dimensions, shades of pink and width of gratings, corresponding to the two cardinal directions of joystick movements. While the overall control of each participant on the ob...

  2. Cooperation arrangements related to technology transfer

    A developing country which considers to launch a nuclear program should put as much as possible efforts to elaborate a program which suits the country's needs as well as reflects its capabilities. It deems advantageous that a developing country makes use of the experience and knowledge in the nuclear field of a partner country already in the phase when exploring the technical and commercial aspects of a nuclear power program. For the different stages of cooperation between two countries a three-level concept appears advisable for establishing the basis for individual cooperation agreement. The first level are agreements between the governments of both countries on joint scientific research projects and technical development programs covering a broad spectrum of activities not limited to the energy sector. At the second level cooperation agreements can already concentrate on the energy sector and e.g. specifically investigate the energy structure of the developing country. If this investigation results in the decision of the developing country to establish a nuclear power program the next level will cover a broad based cooperation in the nuclear field including a large number of different cooperation contracts in various fields. In this stage of bilateral cooperation the main emphasis will be put on industrial cooperation. Cooperation agreements to be concluded between respective partners of both countries may cover fields related to research and development, engineering of a nuclear power plant, manufacturing of its components, erection and installation as well as operation of the plant. The most common agreements refer to technical cooperation, which covers not only the transfer of blueprints but also training of the recipient's personnel in the partner's country and delegation of experts to the recipient's country. The most comprehensive form of cooperation is the foundation of a joint venture company where the technology partner does not only transfer his know

  3. The human capacity building support activities of the Integrated Support Center for Nuclear Nonproliferation and Nuclear Security and the cooperation with the international or foreign organizations which handles human capacity building support

    The Integrated Support Center for Nuclear Nonproliferation and Nuclear Security (ISCN) of the Japan Atomic Energy Agency has started its human capacity building activities, domestically and internationally, for the government officials and employees of companies of emerging nuclear power countries mainly in Asia. In this paper, we will describe the activities of ISCN on capacity building for these countries and also I will briefly describe, focusing on nuclear security, the activities of IAEA, Sandia National Laboratory of United States, Russia and the development of human capacity building support activities of neighboring countries of China and Korea. By doing this, we will describe the relationship and cooperation of ISCN with these organizations and hope that this would help us for the future development with these organizations and ISCN. (author)

  4. Foreign cooperative technology development and transfer

    It is the policy of the US Department of Energy (DOE) that, in pursuing the development of mined geologic repositories in the United States, the waste isolation program will continue to actively support international cooperation and exchange activities that are judged to be in the best interest of the program and in compliance with the Nuclear Waste Policy Act of 1982, Sec. 223. Because there are common technical issues and because technology development often requires large expenditures of funds and dedication of significant capital resources, it is advantageous to cooperate with foreign organizations carrying out similar activities. The DOE's Office of Civilian Radioactive Waste Management is working on cooperative nuclear waste isolation technology development programs with the Organization for Economic Cooperation and Development/Nuclear Energy Agency (OECD/NEA), Canada's Atomic Energy of Canada, Limited (AECL), Sweden, Switzerland, and the Federal Republic of Germany. This paper describes recent technology results that have been obtained in DOE's foreign cooperative programs. Specific technology development studies are discussed for cooperative efforts with Canada, OECD/NEA, and a natural analog project in Brazil

  5. Regional cooperation planning. Project planning for JAEA/SNL regional cooperation on remote monitoring

    Developing cooperation between the JAEA's NPSTC and the NNCA may take advantage of bilateral activities between those parties and SNL. The merger of JNC and JAERI has affected the schedule for JAEA/SNL cooperation. Also, the evolution of the NNCA as an independent agency has slowed the projected schedule for cooperation between the JAEA and the NNCA. A potential schedule for establishment of a quadrilateral remote monitoring system may include interim activities, securing an agreement of some type, and actual establishment of VPN links. A parallel schedule might exist for informing other regional parties and gaining their interest. (author)

  6. Cooperative Mobile Web Browsing

    Perrucci, GP; Fitzek, FHP; Zhang, Qi;

    2009-01-01

    This paper advocates a novel approach for mobile web browsing based on cooperation among wireless devices within close proximity operating in a cellular environment. In the actual state of the art, mobile phones can access the web using different cellular technologies. However, the supported data......-range links can then be used for cooperative mobile web browsing. By implementing the cooperative web browsing on commercial mobile phones, it will be shown that better performance is achieved in terms of increased data rate and therefore reduced access times, resulting in a significantly enhanced web...

  7. RISK MANAGEMENT TECHNIQUES FOR AGRICULTURAL COOPERATIVES: AN EMPIRICAL EVALUATION

    Manfredo, Mark R.; Richards, Timothy J.; McDermott, Scott

    2003-01-01

    While not ignoring risk, agricultural cooperatives tend to accommodate risk through the holding of internal capital reserves rather than engage in active risk management. A lack of information regarding the risk, returns, and the effect on cooperative financial performance of both traditional and innovative risk management strategies is likely a constraint to the adoption of active risk management by cooperatives. In this research, we examine the influence of alternative risk management strat...

  8. Cooperative Learning in Industrial-sized Biology Classes

    Armstrong, Norris; Chang, Shu-Mei; Brickman, Marguerite

    2007-01-01

    This study examined the impact of cooperative learning activities on student achievement and attitudes in large-enrollment (>250) introductory biology classes. We found that students taught using a cooperative learning approach showed greater improvement in their knowledge of course material compared with students taught using a traditional lecture format. In addition, students viewed cooperative learning activities highly favorably. These findings suggest that encouraging students to work in...

  9. Applied Issues of Agritourism Cooperation and Sustainable Endogenous Development

    Helen Theodoropoulou; Roido Mitoula; Olga Astara; Panagiotis Kaldis

    2008-01-01

    This research aims at examining how an agritourism cooperative and its activities promote endogenous development using local human, natural and technological resources in a sustainable way with other local production activities. Technology allows the agritourism cooperative to effectively use local resources and simultaneously to increase its competitiveness in marketing of products. So, the cooperative becomes more competitive in regional and national markets and its economy is connected mor...

  10. Applied Issues of Agritourism Cooperation and Sustainable Endogenous Development

    Helen Theodoropoulou

    2008-01-01

    Full Text Available This research aims at examining how an agritourism cooperative and its activities promote endogenous development using local human, natural and technological resources in a sustainable way with other local production activities. Technology allows the agritourism cooperative to effectively use local resources and simultaneously to increase its competitiveness in marketing of products. So, the cooperative becomes more competitive in regional and national markets and its economy is connected more closely with the national and international economy.

  11. 7 CFR 1484.34 - Must Cooperators adhere to specific standards of ethical conduct?

    2010-01-01

    ... a mutual fund. A Cooperator may collect check-off funds and membership fees that are required for membership in the Cooperator's organization. (c) The Cooperator shall not use program activities or program... the terms of a project agreement. Neither a Cooperator nor its affiliates shall charge a fee...

  12. Evolution of Cooperation in Public Goods Games

    夏承遗; 张娟娟; 王祎玲; 王劲松

    2011-01-01

    We investigate the evolution of cooperation with evolutionary public goods games based on finite populations, where four pure strategies: cooperators, defectors, punishers and loners who are unwilling to participate are considered. By adopting approximate best response dynamics, we show that the magnitude of rationality not only quantitatively explains the experiment results in [Nature (London) 425 (2003) 390], but also it will heavily influence the evolution of cooperation. Compared with previous results of infinite populations, which result in two equilibriums, we show that there merely exists a special equilibrium cooperation. In addition, we characterize that loner's and the relevant high value of bounded rationality will sustain payoff plays an active role in the maintenance of cooperation, which will only be warranted for the low and moderate values of loner's payoff. It thus indicates the effects of rationality and loner's payoff will influence the cooperation. Finally, we highlight the important result that the introduction of voluntary participation and punishment will facilitate cooperation greatly.

  13. Learning to cooperate for cooperative learning

    Yael Sharan

    2014-01-01

    Learning to learn cooperatively requires several changes for teachers and students: in their perception of learning, in their attitudes towards teaching and learning, and in their social and cognitive behaviors in class. This article presents some of the ways that decades of research and practice have developed to enable teachers and students to acquire and adjust to these changes. In the process of change teachers and students are interconnected and interdependent, and together carry out the...

  14. PECULIARITIES OF AGRICULTURAL SERVICE COOPERATIVES DEVELOPMENT IN LVIV REGION

    N.A. Tsymbalista

    2016-06-01

    Full Text Available The article aims to study the recent trends and identify the main problems of the agricultural service cooperatives development. The processes of establishing and functioning of cooperatives in Lviv region are investigated. The dynamics of number of established cooperatives shows a gradual growth in recent year, while the share of operating units is rather low. The size structure of the agricultural service cooperatives in Lviv region proves that the rural population is insufficiently active in participating in cooperatives. The most popular sphere of activity of the cooperatives in the region is dairy production, while the most wide spread type of cooperative is a marketing cooperative. The analysis of the sales of agricultural products by the cooperatives of the region by distribution channels shows that on the present stage of their development service cooperatives can hardly cope with their main objective which is to overcome the monopoly power of commercial intermediaries. This is evidenced by the fact that the share of agricultural production sold by cooperatives to the intermediaries is still significant.

  15. International cooperation and exchanges

    The NNSA continued and enlarged bilateral cooperation with the nuclear energy developing countries and enhanced visiting for high rank leaders of regulatory authorities. Besides, the domestic units for implementing the Convention on Nuclear Safety were settled by coordination

  16. Nuclear cooperation agreements

    Nuclear cooperation agreements are reviewed in tabular form, especially agreements with developing countries. The reporting countries are the USA, the Federal Republic of Germany, Canada, Australia, Japan, and France. A separate EURATOM list is annexed

  17. International cooperation between electricians

    At the opening of the Montreal Forum 'Electricity: the New Millennium', Francois Ailleret as outgoing president of UNIPEDE (International Union of Producers and Distributors of Electricity) spoke in favour of maintaining and even developing international cooperation between electricians. As the liberalization of electrical systems throughout the world increases, leading to a certain competition between electricians, international cooperation may become difficult. The author recalls the remarkable results of this cooperation in the twentieth century and confirms that it remains an irreplaceable communal resource perfectly compatible with competition between electricity companies. This multifaceted cooperation will lead firstly to a whole variety of spin-off benefiting companies and customers. It will also foster the sustainable development of projects to save the environment and combat poverty in the world, clearly illustrated by the situation of these nearly two billion inhabitants of our planet who still today do not enjoy the irreplaceable services of electricity. (author)

  18. Cooperative processing data bases

    Hasta, Juzar

    1991-01-01

    Cooperative processing for the 1990's using client-server technology is addressed. The main theme is concepts of downsizing from mainframes and minicomputers to workstations on a local area network (LAN). This document is presented in view graph form.

  19. Regional National Cooperative Observer

    National Oceanic and Atmospheric Administration, Department of Commerce — NOAA publication dedicated to issues, news and recognition of observers in the National Weather Service Cooperative Observer program. Issues published regionally...

  20. Cooperative Hurricane Network Obs

    National Oceanic and Atmospheric Administration, Department of Commerce — Observations from the Cooperative Hurricane Reporting Network (CHURN), a special network of stations that provided observations when tropical cyclones approached...

  1. Solar cooperatives; Genosse Sonne

    Jensen, Dierk

    2010-06-15

    Not a boom but a trend: Increasingly, solar power plants and other renewables-based systems are financed by cooperatives. This organizational structure requires long-term strategies and some idealism. (orig.)

  2. Landscape Conservation Cooperatives

    US Fish and Wildlife Service, Department of the Interior — Landscape Conservation Cooperatives (LCCs) are public-private partnerships composed of states, tribes, federal agencies, non-governmental organizations,...

  3. Cooperative Weather Observations

    National Oceanic and Atmospheric Administration, Department of Commerce — Monthly logs include a daily account of temperature extremes and precipitation, along with snow data at some locations. U.S. Cooperative Observer Program (COOP)...

  4. Non-cooperative Games

    Damme, E.E.C. van

    2000-01-01

    Non-cooperative games are mathematical models of interactive strategic decision situations.In contrast to cooperative models, they build on the assumption that all possibilities for commitment and contract have been incorporated in the rules of the game.This contribution describes the main models (games in normal form, and games in extensive form), as well as the main concepts that have been proposed to solve these games.Solution concepts predict the outcomes that might arise when the game is...

  5. Cooperative quantum Parrondo's games

    Pawela, Łukasz; Sładkowski, Jan

    2012-01-01

    Coordination and cooperation are among the most important issues of game theory. Recently, the attention turned to game theory on graphs and social networks. Encouraged by interesting results obtained in quantum evolutionary game analysis, we study cooperative Parrondo's games in a quantum setup. The game is modeled using multidimensional quantum random walks with biased coins. We use the GHZ and W entangled states as the initial state of the coins. Our analysis shows than an apparent paradox...

  6. Extending Eurasia Security Cooperation

    2015-01-01

    After 14 years of development, the Shanghai Cooperation Organization (SCO) , has set its sights on goals for the next de-cade at the 15th meeting of the Council of SCO Heads of State that was held in Ufa, the capital of Russia's Bashkortostan Republic, on July 9-10. The SCO, established in Shanghai in 2001, is committed to building fdendly neighbor rela- tions and maintaining security and stability in the Central Asian region through multilateral cooperation.

  7. Transnational Research Co-operation: Opportunities and Challenges for transnational research co-operation

    of the NGOs have a lot of international experience (mainly in Denmark and Germany) as partners in different co-operation projects. Almost all the NGOs have recognized the important role of the scientific information in their activity. NGOs also feel the need for an easy access to required information...... for transnational co-operation like: an investigation/project concerning the driving forces behind urban development,or a co-operation in the field of wastewater reuse and minimization of wastewater loads and discharge, or a service page (internet) to search for potential partners. The governmental institutions...... in order to improve transnational cooperation are identified to be: • Search for national/international project partners • Access to existent co-operation projects or networks • Develop in common project proposals on themes requested by community groups • Exchange information/good operational practices...

  8. Cooperative Tertiary Interaction Network Guides RNA Folding

    Behrouzi, Reza; Roh, Joon Ho; Kilburn, Duncan; Briber, R.M.; Woodson, Sarah A. (JHU); (Maryland)

    2013-04-08

    Noncoding RNAs form unique 3D structures, which perform many regulatory functions. To understand how RNAs fold uniquely despite a small number of tertiary interaction motifs, we mutated the major tertiary interactions in a group I ribozyme by single-base substitutions. The resulting perturbations to the folding energy landscape were measured using SAXS, ribozyme activity, hydroxyl radical footprinting, and native PAGE. Double- and triple-mutant cycles show that most tertiary interactions have a small effect on the stability of the native state. Instead, the formation of core and peripheral structural motifs is cooperatively linked in near-native folding intermediates, and this cooperativity depends on the native helix orientation. The emergence of a cooperative interaction network at an early stage of folding suppresses nonnative structures and guides the search for the native state. We suggest that cooperativity in noncoding RNAs arose from natural selection of architectures conducive to forming a unique, stable fold.

  9. Activities with Argentina. Spring 1999. A U.S. Department of Energy Cooperative Program with the National Atomic Energy Commission of the Argentine Republic

    NONE

    1999-06-01

    In 1989, the US Department of Energy (DOE) responded to the need to redirect resources from weapons production to environmental restoration and waste management by establishing the Office of Environmental Management (EM) and delegated to this office the responsibility of cleaning up the US nuclear weapons complex. Now in its eight year, EM`s mission has three central facets: (1) to assess, remediate, and monitor contaminated sites and facilities; (2) to store, treat, and dispose of waste from past and current operations; and (3) to develop and implement innovative technologies for environmental cleanup. To this end, EM has established domestic and international cooperative technology development programs, including one with the Republic of Argentina. Cooperating with Argentine scientific institutes and industries meets US cleanup objectives by: (1) identifying and accessing Argentine EM-related technologies, thereby leveraging investments and providing cost-savings; (2) improving access to technical information, scientific expertise, and technologies applicable to EM needs; and (3) fostering the development of innovative environmental technologies by increasing US private sector opportunities in Argentina in EM-related areas.

  10. Reading Cooperatively or Independently? Study on ELL Student Reading Development

    Liu, Siping; Wang, Jian

    2015-01-01

    This study examines the effectiveness of cooperative reading teaching activities and independent reading activities for English language learner (ELL) students at 4th grade level. Based on simple linear regression and correlational analyses of data collected from two large data bases, PIRLS and NAEP, the study found that cooperative reading…

  11. Emergence of cooperation with self-organized criticality

    Jeong, Hyeong-Chai

    2010-01-01

    Cooperation and self-organized criticality are two main keywords in current studies of evolution. We propose a generalized Bak-Sneppen model and provide a natural mechanism which accounts for both phenomena simultaneously. We use the prisoner's dilemma games to mimic the interactions among the species. Each species is identified by its cooperation probability and its fitness is given by the payoffs from the neighbors. The species with the least payoff is replaced by a new species with a random cooperation probability. When the neighbors of the least fit one are also replaced with a non-zero probability, a strong cooperation emerges. Bak-Sneppen process builds a self-organized structure so that the cooperation can emerge even in the parameter region where a uniform or random population decreases the number of cooperators. The emergence of cooperation is due to the same dynamical correlation which leads to self-organized criticality in replacement activities.

  12. Emergence of cooperation with self-organized criticality

    Park, Sangmin; Jeong, Hyeong-Chai

    2012-02-01

    Cooperation and self-organized criticality are two main keywords in current studies of evolution. We propose a generalized Bak-Sneppen model and provide a natural mechanism which accounts for both phenomena simultaneously. We use the prisoner's dilemma games to mimic the interactions among the members in the population. Each member is identified by its cooperation probability, and its fitness is given by the payoffs from neighbors. The least fit member with the minimum payoff is replaced by a new member with a random cooperation probability. When the neighbors of the least fit one are also replaced with a non-zero probability, a strong cooperation emerges. The Bak-Sneppen process builds a self-organized structure so that the cooperation can emerge even in the parameter region where a uniform or random population decreases the number of cooperators. The emergence of cooperation is due to the same dynamical correlation that leads to self-organized criticality in replacement activities.

  13. DOE/ABACC safeguards cooperation

    In 1994, the US Department of Energy (DOE) and the Brazilian-Argentine Agency for Accounting and Control of Nuclear Materials (ABACC) signed a safeguards cooperation agreement. The agreement provides for cooperation in the areas of nuclear material control, accountancy, verification, and advanced containment and surveillance technologies for international safeguards applications. ABACC is an international safeguards organization responsible for verifying the commitments of a 1991 bilateral agreement between Argentina and Brazil in which both countries agreed to submit all nuclear material in all nuclear activities to a Common System of Accounting and Control of Nuclear Materials (SCCC). DOE provides critical assistance (including equipment and training) through the Office of Nonproliferation and National Security to countries and international organizations to enhance their capabilities to control and verify nuclear material inventories. Specific activities initiated under the safeguards agreement include: (1) active US participation in ABACC's safeguards training courses, (2) joint development of specialized measurement training workshops, (3) characterization of laboratory standards, and (4) development and application of an extensive analytical laboratory comparison program. The results realized from these initial activities have been mutually beneficial in regard to strengthening the application of international safeguards in Argentina and Brazil

  14. Considering Cooperation: A Guide For New Cooperative Development

    Henehan, Brian M.; Anderson, Bruce L.

    2001-01-01

    This publication reviews the key elements needed for successful formation and development of new cooperative businesses. The motivation for and process of forming cooperatives are discussed. Six phases of cooperative formation are presented including: 1) identifying the opportunity, 2) building consensus on the potential for a cooperative, 3) developing trust among potential members, 4) securing member commitment, 5) involving other stakeholders, and 6) starting up the cooperative enterprise....

  15. PLANNING AND COORDINATION OF ACTIVITIES SUPPORTING THE RUSSIAN SYSTEM OF CONTROL AND ACCOUNTING OF NUCLEAR MATERIALS AT ROSATOM FACILITIES IN THE FRAMEWORK OF THE U.S.-RUSSIAN COOPERATION

    The MC and A Equipment and Methodological Support Strategic Plan (MEMS SP) for implementing modern MC and A equipment and methodologies at Rosatom facilities has been developed within the framework of the U.S.-Russian MPC and A Program. This plan developed by the Rosatom's Russian MC and A Equipment and Methodologies (MEM) Working Group and is coordinated by that group with support and coordination provided by the MC and A Measurements Project, Office of National Infrastructure and Sustainability, US DOE. Implementation of different tasks of the MEMS Strategic Plan is coordinated by Rosatom and US-DOE in cooperation with different U.S.-Russian MC and A-related working groups and joint site project teams. This cooperation allows to obtain and analyze information about problems, current needs and successes at Rosatom facilities and facilitates solution of the problems, satisfying the facilities' needs and effective exchange of expertise and lessons learned. The objective of the MEMS Strategic Plan is to enhance effectiveness of activities implementing modern equipment and methodologies in the Russian State MC and A system. These activities are conducted within the joint Russian-US MPC and A program aiming at reduction of possibility for theft or diversion of nuclear materials and enhancement of control of nuclear materials

  16. Advantages and disadvantages of cooperative learning in English teaching

    温晓慧

    2015-01-01

    The group cooperative learning is a studentcentered learning activities.In the practice of the English teaching reform,cooperative learning is beneficial to reflect the students’ main body status,to provide students more chance to exercise,promoting the all-round development of students,and is conducive to the harmonious relationship between teachers and students; at the same time,cooperative learning also has some disadvantages,such as hard to control the student,good students become the authority of the group activities,cooperation too often that ignored the students’ independent thinking,etc.

  17. Advantages and disadvantages of cooperative learning in English teaching

    温晓慧

    2015-01-01

    The group cooperative learning is a student-centered learning activities.In the practice of the English teaching reform,cooperative learning is beneficial to reflect the students' main body status,to provide students more chance to exercise,promoting the all-round development of students,and is conducive to the harmonious relationship between teachers and students; at the same time,cooperative learning also has some disadvantages,such as hard to control the student,good students become the authority of the group activities,cooperation too often that ignored the students' independent thinking,etc.

  18. The Proposal of Model for Building Cooperation Management in Company

    Josef Vodák

    2015-12-01

    Full Text Available The goal of the article is to use detailed literature analysis and findings of an empirical research, and to propose model for building cooperation management in a company. The article brings a valuable tool to company managers in a form of a complex and detailed model to achieve successful implementation of cooperation management in a company. The article thus provides a tool for company managers for managing their cooperation projects and activities. Use of this tool is meant to help minimize occurrence of conflict situations and to support smooth progress of cooperation activities.

  19. Cooperative robotic sentry vehicles

    Feddema, John T.; Lewis, Christopher L.; Klarer, Paul; Eisler, G. R.; Caprihan, Rahul

    1999-08-01

    As part of a project for the Defense Advanced Research Projects Agency, Sandia National Laboratories' Intelligent Systems and Robotics Center is developing and testing the feasibility of a cooperative team of robotic sentry vehicles to guard a perimeter and to perform a surround task. This paper describes on-going activities in the development of these robotic sentry vehicles. To date, we have developed a robotic perimeter detection system which consists of eight 'Roving All Terrain Lunar Explorer Rovers' (RATLER), a laptop-based base-station, and several Miniature Intrusion Detection Sensors (MIDS). A radio frequency receiver on each of the RATLER vehicles alerts the sentry vehicles of alarms from the hidden MIDS. When an alarm is received, each vehicle decides whether it should investigate the alarm based on the proximity of itself and the other vehicles to the alarm. As one vehicle attends an alarm, the other vehicles adjust their position around the perimeter to better prepare for another alarm. For the surround task, both potential field and A* search path planners have been added to the base-station and vehicles. At the base-station, the operator specifies goal and exclusion regions on a GIS map. The path planner generates vehicles paths that are previewed by the operator. Once the operator has validated the path, the appropriate information is downloaded t the vehicles. For the potential field path planner, the polygons and line segments that represent the obstacles and goals are downloaded to the vehicles, instead of the simulated paths. On board the vehicles, the same potential field path planner generates the path except that it uses the true location of itself and the nearest neighboring vehicle. For the A* path planner, the actual path is downloaded to the vehicles because of limited on-board computational power.

  20. Decision Making and Cooperation Restrictions.

    2000-01-01

    Decision making by various individuals can result in conflicts or cooperation between these individuals. Game theory deals with both the mathematical modeling of these situations of conflict and cooperation and with the analysis of these models using math atical techniques. This thesis focuses on decision making and cooperation restrictions and can roughly be divided into two parts. The first part provides an analysis of cooperative games with exogenously given cooperation structures. Three t...

  1. Decision making and cooperation restrictions

    Slikker, M.

    2000-01-01

    Decision making by various individuals can result in conflicts or cooperation between these individuals. Game theory deals with both the mathematical modeling of these situations of conflict and cooperation and with the analysis of these models using math atical techniques. This thesis focuses on decision making and cooperation restrictions and can roughly be divided into two parts. The first part provides an analysis of cooperative games with exogenously given cooperation structures. Three t...

  2. Fundamental Limits of Cooperation

    Lozano, Angel; Andrews, Jeffrey G

    2012-01-01

    Cooperation is viewed as a key ingredient for interference management in wireless systems. This paper shows that cooperation has fundamental limitations. The main result is that even full cooperation between transmitters cannot in general change an interference-limited network to a noise-limited network. The key idea is that there exists a spectral efficiency upper bound that is independent of the transmit power. First, a spectral efficiency upper bound is established for systems that rely on pilot-assisted channel estimation; in this framework, cooperation is shown to be possible only within clusters of limited size, which are subject to out-of-cluster interference whose power scales with that of the in-cluster signals. Second, an upper bound is also shown to exist when cooperation is through noncoherent communication; thus, the spectral efficiency limitation is not a by-product of the reliance on pilot-assisted channel estimation. Consequently, existing literature that routinely assumes the high-power spect...

  3. Evolution, epigenetics and cooperation

    Patrick Bateson

    2014-04-01

    Explanations for biological evolution in terms of changes in gene frequencies refer to outcomes rather than process. Integrating epigenetic studies with older evolutionary theories has drawn attention to the ways in which evolution occurs. Adaptation at the level of the gene is givingway to adaptation at the level of the organism and higher-order assemblages of organisms. These ideas impact on the theories of how cooperation might have evolved. Two of the theories, i.e. that cooperating individuals are genetically related or that they cooperate for self-interested reasons, have been accepted for a long time. The idea that adaptation takes place at the level of groups is much more controversial. However, bringing together studies of development with those of evolution is taking away much of the heat in the debate about the evolution of group behaviour.

  4. Research on Multi-Dimension Cooperative Game of Enterprises

    Lu Cheng; Peng Cheng

    2013-01-01

    Because of enterprise’s own resources can not meet the needs of the innovative activities, more and more enterprises looking forward to cooperative innovation with others. In the cooperation process, for multidimensional, there is a game behavior. Due to the fact that incomplete information exists in the process of cooperation, most multidimensional game belongs to incomplete information game. According to the definition of fuzzy stable set and solution, in this study, the fuzzy mathematics i...

  5. Cooperate or Free Ride?

    Hansen, Per H.

    2012-01-01

    the establishment of the BIS and free riders in the Austrian crisis, even though there were marked differences in their attitude to international cooperation. These results run counter to the views of those International Political Economy (IPE) theorists who argue that small states should be in favour...... of international cooperation. On the other hand, the evidence seems to confirm Kindleberger's hypothesis that small countries were free riding during the international financial crisis of 1931, and that therefore there is a need for some coordinating mechanism, or a hegemon, in such crises....

  6. Cooperative internal conversion process

    Kálmán, Péter

    2015-01-01

    A new phenomenon, called cooperative internal conversion process, in which the coupling of bound-free electron and neutron transitions due to the dipole term of their Coulomb interaction permits cooperation of two nuclei leading to neutron exchange if it is allowed by energy conservation, is discussed theoretically. General expression of the cross section of the process is reported in one particle nuclear and spherical shell models as well in the case of free atoms (e.g. noble gases). A half-life characteristic of the process is also determined. The case of $Ne$ is investigated numerically. The process may have significance in fields of nuclear waste disposal and nuclear energy production.

  7. Subradiant split Cooper pairs

    Cottet, Audrey; Kontos, Takis; Yeyati, Alfredo Levy

    2011-01-01

    We suggest a way to characterize the coherence of the split Cooper pairs emitted by a double-quantum-dot based Cooper pair splitter (CPS), by studying the radiative response of such a CPS inside a microwave cavity. The coherence of the split pairs manifests in a strongly nonmonotonic variation of the emitted radiation as a function of the parameters controlling the coupling of the CPS to the cavity. The idea to probe the coherence of the electronic states using the tools of Cavity Quantum Ele...

  8. Cooperative Prototyping Experiments

    Bødker, Susanne; Grønbæk, Kaj

    1989-01-01

    tried to achieve a fluent work-like evaluation of prototypes where users envisioned future work with a computer tool, at the same time as we made on-line modifications of prototypes in cooperation with the users when breakdown occur in their work-like evaluation. The experiments showed that it was...... possible to make a number of direct manipulation changes of prototypes in cooperation with the users, in interplay with their fluent work-like evaluation of these. However, breakdown occurred in the prototyping process when we reached the limits of the direct manipulation support for modification. From...

  9. Introduction: cooperative learning

    José-Manuel Serrano

    2014-10-01

    Full Text Available The principal objective of this revision is the recognition of cooperative learning as a highly effective strategy for the accomplishment of the general goals in learning. The different investigations assessed validate the potential that a cooperative organization of the classroom could entail for academic achievement, self-esteem, interpersonal attraction or social support. The solidity of the existing research contributes to its external and internal validity and, thus, to conclude that the results are consistent and can be extrapolated to different cultures, ethnic groups or countries.

  10. A study on the enhancement of nuclear cooperation with African countries including utilization of radioisotope

    Yang, Maeng Ho; Oh, K. B; Lee, H. M. and others

    2005-05-15

    In this study, potential countries for nuclear cooperation in African region and possible cooperation areas were investigated between Korea and African countries including radioisotopes and more fields were also analysed in depth in order to suggest the recommendations for future cooperation to be considered as follows; First, current status and perspectives of demand and supply of energy and electricity in the African countries, use and development of nuclear energy and international nuclear cooperation were analyzed. Second, current status of nuclear cooperation between Korea and African countries were investigated as well as analysis of future cooperation potential and countries having potential for nuclear cooperation and possible cooperative activities were suggested considering potential of nuclear market in mid- and long term base and step by step. Third, desirable strategies and directions for the establishment and promotion of nuclear cooperation relations between Korea and African developing countries were suggested in order to develope cooperative relations in efficient and effective manners with African developing countries.

  11. A study on the enhancement of nuclear cooperation with African countries including utilization of radioisotope

    In this study, potential countries for nuclear cooperation in African region and possible cooperation areas were investigated between Korea and African countries including radioisotopes and more fields were also analysed in depth in order to suggest the recommendations for future cooperation to be considered as follows; First, current status and perspectives of demand and supply of energy and electricity in the African countries, use and development of nuclear energy and international nuclear cooperation were analyzed. Second, current status of nuclear cooperation between Korea and African countries were investigated as well as analysis of future cooperation potential and countries having potential for nuclear cooperation and possible cooperative activities were suggested considering potential of nuclear market in mid- and long term base and step by step. Third, desirable strategies and directions for the establishment and promotion of nuclear cooperation relations between Korea and African developing countries were suggested in order to develope cooperative relations in efficient and effective manners with African developing countries

  12. Negative cooperativity in regulatory enzymes.

    Levitzki, A; Koshland, D E

    1969-04-01

    Negative cooperativity has been observed in CTP synthetase, an allosteric enzyme which contains a regulatory site. Thus, the same enzyme exhibits negative cooperativity for GTP (an effector) and glutamine (a substrate) and positive cooperativity for ATP and UTP (both substrates). In the process of the delineation of these phenomena, diagnostic procedures for negative cooperativity were developed. Application of these procedures to other enzymes indicates that negative cooperativity is a characteristic of many of them. These findings add strong support for the sequential model of subunit interactions which postulates that ligand-induced conformational changes are responsible for regulatory and cooperative phenomena in enzymes. PMID:5256410

  13. Predicting Human Cooperation

    Nay, John J.; Vorobeychik, Yevgeniy

    2016-01-01

    The Prisoner’s Dilemma has been a subject of extensive research due to its importance in understanding the ever-present tension between individual self-interest and social benefit. A strictly dominant strategy in a Prisoner’s Dilemma (defection), when played by both players, is mutually harmful. Repetition of the Prisoner’s Dilemma can give rise to cooperation as an equilibrium, but defection is as well, and this ambiguity is difficult to resolve. The numerous behavioral experiments investigating the Prisoner’s Dilemma highlight that players often cooperate, but the level of cooperation varies significantly with the specifics of the experimental predicament. We present the first computational model of human behavior in repeated Prisoner’s Dilemma games that unifies the diversity of experimental observations in a systematic and quantitatively reliable manner. Our model relies on data we integrated from many experiments, comprising 168,386 individual decisions. The model is composed of two pieces: the first predicts the first-period action using solely the structural game parameters, while the second predicts dynamic actions using both game parameters and history of play. Our model is successful not merely at fitting the data, but in predicting behavior at multiple scales in experimental designs not used for calibration, using only information about the game structure. We demonstrate the power of our approach through a simulation analysis revealing how to best promote human cooperation. PMID:27171417

  14. Cooperation Or Conflict?

    2007-01-01

    Iran’s recent actions have created confusion and heightened doubt about the future of the nuclear issue Recent events involving Iran have produced high drama. First, the country said it would cooperate with the International Atomic Energy Agency (IAEA) on the

  15. Supranational Cooperation in Europe

    de Deugd, Nienke; Stamm, Katharina; Westerman, Wim

    2013-01-01

    The sovereign debt crisis and the euro crisis have prompted heads of state and government in Europe to intensify supranational cooperation. However, some political leaders and policy makers aim for more. They propose the introduction of a common European economic government that would prevent Europe

  16. Cooperative Mobile Sensing Networks

    Roberts, R S; Kent, C A; Jones, E D; Cunningham, C T; Armstrong, G W

    2003-02-10

    A cooperative control architecture is presented that allows a fleet of Unmanned Air Vehicles (UAVs) to collect data in a parallel, coordinated and optimal manner. The architecture is designed to react to a set of unpredictable events thereby allowing data collection to continue in an optimal manner.

  17. Cooperating with the future

    Hauser, Oliver P.; Rand, David G.; Peysakhovich, Alexander; Nowak, Martin A.

    2014-07-01

    Overexploitation of renewable resources today has a high cost on the welfare of future generations. Unlike in other public goods games, however, future generations cannot reciprocate actions made today. What mechanisms can maintain cooperation with the future? To answer this question, we devise a new experimental paradigm, the `Intergenerational Goods Game'. A line-up of successive groups (generations) can each either extract a resource to exhaustion or leave something for the next group. Exhausting the resource maximizes the payoff for the present generation, but leaves all future generations empty-handed. Here we show that the resource is almost always destroyed if extraction decisions are made individually. This failure to cooperate with the future is driven primarily by a minority of individuals who extract far more than what is sustainable. In contrast, when extractions are democratically decided by vote, the resource is consistently sustained. Voting is effective for two reasons. First, it allows a majority of cooperators to restrain defectors. Second, it reassures conditional cooperators that their efforts are not futile. Voting, however, only promotes sustainability if it is binding for all involved. Our results have implications for policy interventions designed to sustain intergenerational public goods.

  18. EFFECTIVENESS OF COOPERATIVE LEARNING STRATEGIES IN DEVELOPMENT OF COOPERATIVE SKILLS

    K. C. Kulkarni

    2015-01-01

    Cooperative Learning Skills :David Johnson and Roger Johnson (2009a) explain five elements that define true cooperative learning groups : (i) Positive interdependence ; (ii) Promotive interaction ; (iii) Individual accountability ; (iv) Collaborative and social skills ; (v) Group processing.

  19. To Cooperate or Not to Cooperate: Why Behavioural Mechanisms Matter.

    Bernard, Arthur; André, Jean-Baptiste; Bredeche, Nicolas

    2016-05-01

    Mutualistic cooperation often requires multiple individuals to behave in a coordinated fashion. Hence, while the evolutionary stability of mutualistic cooperation poses no particular theoretical difficulty, its evolutionary emergence faces a chicken and egg problem: an individual cannot benefit from cooperating unless other individuals already do so. Here, we use evolutionary robotic simulations to study the consequences of this problem for the evolution of cooperation. In contrast with standard game-theoretic results, we find that the transition from solitary to cooperative strategies is very unlikely, whether interacting individuals are genetically related (cooperation evolves in 20% of all simulations) or unrelated (only 3% of all simulations). We also observe that successful cooperation between individuals requires the evolution of a specific and rather complex behaviour. This behavioural complexity creates a large fitness valley between solitary and cooperative strategies, making the evolutionary transition difficult. These results reveal the need for research on biological mechanisms which may facilitate this transition. PMID:27148874

  20. A User Cooperation Stimulating Strategy Based on Cooperative Game Theory in Cooperative Relay Networks

    Ping Zhang

    2009-01-01

    Full Text Available This paper proposes a user cooperation stimulating strategy among rational users. The strategy is based on cooperative game theory and enacted in the context of cooperative relay networks. Using the pricing-based mechanism, the system is modeled initially with two nodes and a Base Station (BS. Within this framework, each node is treated as a rational decision maker. To this end, each node can decide whether to cooperate and how to cooperate. Cooperative game theory assists in providing an optimal system utility and provides fairness among users. Under different cooperative forwarding modes, certain questions are carefully investigated, including “what is each node's best reaction to maximize its utility?” and “what is the optimal reimbursement to encourage cooperation?” Simulation results show that the nodes benefit from the proposed cooperation stimulating strategy in terms of utility and thus justify the fairness between each user.

  1. Harvest-Then-Cooperate: Wireless-Powered Cooperative Communications

    Chen, He; Li, Yonghui; Rebelatto, Joao Luiz; Uchoa-Filhoand, Bartolomeu F.; Vucetic, Branka

    2014-01-01

    In this paper, we consider a wireless-powered cooperative communication network consisting of one hybrid access-point (AP), one source, and one relay. In contrast to conventional cooperative networks, the source and relay in the considered network have no embedded energy supply. They need to rely on the energy harvested from the signals broadcasted by the AP for their cooperative information transmission. Based on this three-node reference model, we propose a harvest-then-cooperate (HTC) prot...

  2. International relations and co-operation

    This bulletin contains information about activities of the Nuclear Regulatory Authority of the Slovak Republic (UJD). In this leaflet the international relations and co-operation of the UJD are presented. International community is aware of the fact that nuclear energy shall be used exclusively for peaceful purposes and on condition of high standard of nuclear safety. Therefore, the long-term aim of UJD in the area of international relations is to maintain and develop internationally recognised system of state supervision upon the peaceful use of nuclear energy and to reach internationally accepted level of nuclear safety in the Slovak Republic. There are many important international treaties (Treaty on the Non-proliferation of Nuclear Weapons Convention on Nuclear Safety, etc.) to which slovakia is a party. In order to meet the obligations of these treaties UJD has the main aim for contribute to the process of international disarmament, and to a mutually advantageous co-operation. By means of the most important international organisations (e.g. International Atomic Energy Agency) the Slovak Republic actively participates in the international co-operation. Under the leadership of UJD, Slovak institutions participate in many projects and activities which have the aim to improve the safety of nuclear international obligations. In addition, UJD actively participates in the integration process of the Slovak Republic into European and Trans-Atlantic structures. Since 1993 the co-operation with the European Commission and the Nuclear Energy Agency of Organisation for Economic Co-operation and development (OECD/NEA) has been successfully implemented. Besides multilateral co-operation UJD attaches extraordinary importance to bilateral co-operation, in particular with neighbouring countries. Regular meetings of senior Slovak experts with foreign experts are organised, with the aim to exchange the newest experiences and information on peaceful use of nuclear energy. Also in

  3. Research on Multi-Dimension Cooperative Game of Enterprises

    Lu Cheng

    2013-04-01

    Full Text Available Because of enterprise’s own resources can not meet the needs of the innovative activities, more and more enterprises looking forward to cooperative innovation with others. In the cooperation process, for multidimensional, there is a game behavior. Due to the fact that incomplete information exists in the process of cooperation, most multidimensional game belongs to incomplete information game. According to the definition of fuzzy stable set and solution, in this study, the fuzzy mathematics is used in multidimensional game and provides league members with incomplete information state problem decision support. At the same time, provides new ideas to the analysis of dynamic gains among cooperation process.

  4. PHYSICAL ACTIVITY STAGES OF CHANGE, SELF-EFFICACY, AND PERCEIVED NEEDS AND INTERESTS OF COOPERATIVE EXTENSION FAMILY AND CONSUMER SCIENCES AGENTS AND CLIENTELE.

    Stimpson, Tara Spruce

    2000-01-01

    Extensive research has clearly revealed that people of all ages can enhance their health by simply incorporating moderate levels of physical activity into their daily routine. Physical activity significantly reduces the risk of morbidity and mortality from coronary heart disease while providing protective benefits from hypertension, diabetes mellitus, osteoporosis, and colon cancer. Physical activity can lead to positive psychological improvements by decreasing levels of anxiety and depress...

  5. Performance Evaluation Model for Product Quality Control of Vegetable Cooperatives

    Li Qin

    2013-08-01

    Full Text Available The purpose of this study is to investigate the product quality control performance of vegetable cooperatives in China, using Heilongjiang province as a case. This study applies fuzzy integral theory to develop a comprehensive evaluation model and analyzes the product quality control performance of the vegetable cooperatives. The results show that the performance of vegetable cooperatives in the production process is the highest. That is, vegetable cooperatives have important effect on the performance of product quality control mainly in the production process. Through the large-scale operation and the implementation of standardized production, vegetable cooperatives can effectively transform the decentralized production into the unified production. To exert the role of vegetable cooperatives in the product quality control, the incentive systems and the financial support policies should be improved and actively implement the brand strategy.

  6. Murder They Wrote. A Cross-Curricular Cooperative Learning Experience.

    Gaither, Linda

    This document contains a cross-curricular cooperative learning experience that is designed to give high school students career and technical educational experiences in the areas of forensic sciences and criminalistics by doing the forensic work to "solve" a fictitious murder. The activities included in the cooperative learning experience are…

  7. On the Free-Rider Problem in Cooperative Learning.

    Joyce, William B.

    1999-01-01

    Cooperative-learning activities were implemented in one of two sections of an accounting class. The problem of "free riders"--students who do not participate fully in cooperative-learning groups--was reduced by having group members rotate midway through the course. (SK)

  8. Cooperation and competition on the path to fusion energy

    The United States, the European Community, and Japan are actively considering whether worthwhile advantages lie in increased cooperation among their respective programs of research and development in magnetically confined fusion. To help answer that question for the United States, this report examines why cooperation is a policy option, what might be done, and how

  9. Cooperative Cataloging of Latin-American Books: The Unfulfilled Promise.

    Grover, Mark L.

    1991-01-01

    Discussion of cooperative activities among libraries focuses on cataloging of Latin American materials among research libraries. Differences in motivation for cooperation in acquisitions and in cataloging are discussed; and a study is described that examined which libraries were providing online cataloging, and differences between OCLC and RLIN…

  10. International Cooperation at the Institute of Botany

    Fu Yanfeng

    2003-01-01

    @@ The CAS Institute of Botany (IBCAS) has a history more than 70 years. During the current drive of China's economic and scientific reforms, the IBCAS,in the context of the world S&T development trend and in line with its own superiorities, is active in carrying out international cooperation and exchanges.

  11. Intergroup Relations in Cooperative Learning Groups.

    Farivar, Sydney

    This study investigated the impact of a sequence of social relationship activities on regard for classmates and teammates in middle school (grade 7) mathematics classes using cooperative learning. The sample consisted of 184 students (55% Hispanic American, 27% White, 14% Black, and 3% Asian American) in a city in Los Angeles County (California).…

  12. International Cooperation at CAS Since 1998

    2010-01-01

    @@ Since 1998 when the Knowledge Innovation Program (KIP) was launched,the rapid development of CAS has offered great opportunities to forge international cooperation.Focusing on capacity building to effectively absorb global innovation resources and through organizing major innovative activities,CAS has increasingly expanded and intensified international partnerships.

  13. Soviet/Russian-American space cooperation

    Karash, Yuri Y.

    This dissertation seeks to answer two questions: (1) what are the necessary conditions for the emergence of meaningful space cooperation between Russia and the United States, and (2) might this cooperation continue developing on its own merit, contributing to the further rapprochement between the two countries, even if the conditions that originated the cooperation were to change? The study examines the entire space era up to this point, 1957 to 1997, from the first satellite launch through the joint U.S.-Russian work on the ISS project. It focuses on the analysis of three distinct periods of possible and real cooperation between the United States and the Soviet Union/Russia. The first possibility for a limited Soviet-American cooperation in space emerged in the late 1950s, together with the space age, and continued until the mid-1960s. The major potential joint project of this period was a human expedition to the Moon. The global competition/confrontation between the two countries prevented actual cooperation. The second period was from the late 1960s until 1985 with consideration of experimental docking missions, including the docking of a reusable U.S. shuttle to a Soviet Salyut-type station. The global U.S.-Soviet competition still continued, but the confrontation was replaced by detente for a brief period of time lasting from the end of 1960s until mid-1970s. Detente gave the first example of U.S.-Soviet cooperation in space---the Apollo-Soyuz joint space flight (ASTP) which took place in 1975. However, the lack of interest of political leaderships in continuation of broad-scale cooperation between the two countries, and the end of detente, removed ASTP-like projects out of question at least until 1985. The third period started together with Mikhail Gorbachev's Perestroika in 1985 and continues until now. It involves almost a hundred of joint space projects both at the governmental and at the private sectors levels. The mainstream of the joint activities

  14. Cooperating for assisting intelligently operators

    We are in the process of an intelligent cooperative system in a nuclear plant application. The system must cooperate with an operator who accomplishes a task of supervision of a real-world process. We point out in the paper that a cooperation between a cooperative system and an operator has two modes: a waking state and a participating state. During the waking state, the system observes the operator's behavior and the consequences on the process. During the participation state, the cooperative system builds jointly with the user a solution to the problem. In our approach, the cooperation depends on the system capabilities to explain, to incrementally acquire knowledge and to make explicit the context of the cooperation. We develop these ideas in the framework of the design of the cooperative system in the nuclear plant. (authors). 22 refs., 1 fig

  15. Merging Cooperatives: Planning, Negotiating, Implementing

    Swanson, Bruce L.

    1985-01-01

    Guidelines for reorganization of cooperatives through merger, acquisition, or consolidation are provided. Planning, negotiating, and implementing phases of reorganization are covered. Items from actual combinations of cooperatives are reported as they relate to phases of the reorganization process.

  16. The Implementation of Project and Research Activities in Working with Gifted Children in Terms of School-University Network Cooperation (Regional Aspect)

    Abdrafikova, Albina R.; Akhmadullina, Rimma M.; Singatullova, Aliya A.

    2014-01-01

    The article deals with regional experience in using modern strategies in teaching gifted children. The value of project and research activity is actualized as one of the most effective educational technologies in work with gifted children. The article shows examples of organization of combined project and research activities of student-teachers…

  17. South-South Development Cooperation and Soft Power. The case of Brazil's foreign policy and technical cooperation

    Bry, Sandra

    's participation in development cooperation and how these international political ambitions influence the project model of its South-South Development Cooperation, called technical cooperation. This was done by investigating the manifestations of ‘soft power’ in Brazilian development cooperation activities in...... of the subject's positive reception of the agent's attractive actions without which a country's soft power is non-existent. Therefore this thesis maintains that soft power theory should shift its current analytical focus from the agent to the subject and enhance the analysis on the role of subject...

  18. Prospects of ASEAN Legal Cooperation

    Agus Riyanto

    2016-01-01

    Association of Southeast Asian Nations (ASEAN) is a regional organization in the countries of Southeast Asia established in Bangkok, Thailand, on August 8, 1967 (the Bangkok Declaration) by Indonesia, Malaysia, Philippines, Singapore, and Thailand. One form of cooperation that could further encourage the establishment of ASEAN's goal was legal cooperation. This was because, this cooperation could further strengthen cooperation in politics, economy, social and culture in Southeast Asia. ...

  19. Cooperation in regional nuclear training

    This paper presents an overview of the nuclear training currently being undertaken in the countries of the co-authors, and considers the degree to which training problems are amenable to common solutions such as cooperative regional training programs. Different types of cooperation are discussed including the development of regional and international training centers, cooperative bilateral and multilateral training, and the proposed US International Nuclear Safety Training Academy. The paper provides suggestions of ways for enhancing regional cooperation

  20. Financial Performance of Dairy Cooperatives

    Stafford, Thomas H.

    1985-01-01

    Combined balance sheets and operating statements were used to develop benchmark financial ratios for dairy marketing cooperatives. Data from 291 cooperatives were summarized for five types of dairy cooperatives, then by three types and three size combinations. Both type and size of cooperative made differences in most of the 16 financial ratios calculated as well as in the common size balance sheets and operating statements.

  1. Cooperative networking in a heterogeneous wireless medium

    Ismail, Muhammad

    2013-01-01

    This brief focuses on radio resource allocation in a heterogeneous wireless medium. It presents radio resource allocation algorithms with decentralized implementation, which support both single-network and multi-homing services. The brief provides a set of cooperative networking algorithms, which rely on the concepts of short-term call traffic load prediction, network cooperation, convex optimization, and decomposition theory. In the proposed solutions, mobile terminals play an active role in the resource allocation operation, instead of their traditional role as passive service recipients in

  2. International cooperation in cold forging technology

    Bay, Niels; Lange, K

    1992-01-01

    International cooperation in the field of cold forging technology started in 1961 by formation of the OECD Group of Experts on Metal Forming. In 1967 this group was transformed into the International Cold Forging Group, ICFG, an independent body which has now been operative for 25 years. Members of...... by cooperative activities or by instigating national research. These subgroups have produced 9 data sheets and 7 guidelines on subjects such as materials, tool design and construction, calculation methods for cold forging tools, manufacture of slugs, lubrication aspects and small quantity production...

  3. CTBTO international cooperation workshop

    The International Cooperation Workshop took place in Vienna, Austria, on 16 and 17 November 1998, with the participation of 104 policy/decision makers, Research and Development managers and diplomatic representatives from 58 States Signatories to the Comprehensive Nuclear-Test Ban Treaty (CTBT). The Workshop attempted to develop Treaty stipulations to: promote cooperation to facilitate and participate in the fullest possible exchange relating to technologies used in the verification of the Treaty; enable member states to strengthen national implementation of verification measures, and to benefit from the application of such technologies for peaceful purposes. The potential benefits arising from the CTBT monitoring, analysis and data communication systems are multifaceted, and as yet unknown. This Workshop provided the opportunity to examine some of these possibilities. An overview of the CTBT verification regime on the general aspects of the four monitoring technologies (seismic, hydro-acoustic, infrasound and radionuclides), including some of the elements that are the subject of international cooperation, were presented and discussed. Questions were raised on the potential benefits that can be derived by participating in the CTBT regime and broad-based discussions took place. Several concrete proposals on ways and means to facilitate and promote cooperation among States Signatories were suggested. The main points discussed by the participants can be summarized as follows: the purpose of the CTBT Organization is to assist member states to monitor Treaty compliance; the CTBT can be a highly effective technological tool which can generate wide-ranging data, which can be used for peaceful purposes; there are differences in the levels of technology development in the member states that is why peaceful applications should be supported by the Prep Com for the benefit of all member states, whether developed or developing, training being a key element to optimize the CTBT

  4. Cooperative Learning in Elementary Schools

    Slavin, Robert E.

    2015-01-01

    Cooperative learning refers to instructional methods in which students work in small groups to help each other learn. Although cooperative learning methods are used for different age groups, they are particularly popular in elementary (primary) schools. This article discusses methods and theoretical perspectives on cooperative learning for the…

  5. COOPERATIVE LEARNING IN LARGE CLASSES

    GuoXiangju

    2004-01-01

    Teaching college English in large classes is a new challenge to teachers. To meet this challenge, the strategy of cooperative learning is practicable. This paper introduces cooperative learning and describes the experiment results, which prove the advantages of cooperative learning over competitive learning or individualistic learning.

  6. Enlightening Advantages of Cooperative Learning

    Faryadi, Qais

    2007-01-01

    This appraisal discusses the notion that cooperative learning enhances learners' emotional and social performance. It also observes the perception that cooperative learning dramatically improves students' academic accomplishment. This review also examines the definition of cooperative learning and attempts to define it through the lens of renowned…

  7. Gender and Cooperation in Children

    Cardenas, Juan-Camilo; Dreber, Anna; Essen, Emma von; Ranehill, Eva

    between Colombia and Sweden overall. However, Colombian girls cooperate less than Swedish girls. We also find indications that girls in Colombia are less cooperative than boys. Finally, there is also a tendency for children to be more cooperative with boys than with girls on average....

  8. Cooperative effects of neuronal ensembles.

    Rose, G; Siebler, M

    1995-01-01

    Electrophysiological properties of neurons as the basic cellular elements of the central nervous system and their synaptic connections are well characterized down to a molecular level. However, the behavior of complex noisy networks formed by these constituents usually cannot simply be derived from the knowledge of its microscopic parameters. As a consequence, cooperative phenomena based on the interaction of neurons were postulated. This is a report on a study of global network spike activity as a function of synaptic interaction. We performed experiments in dissociated cultured hippocampal neurons and, for comparison, simulations of a mathematical model closely related to electrophysiology. Numeric analyses revealed that at a critical level of synaptic connectivity the firing behavior undergoes a phase transition. This cooperative effect depends crucially on the interaction of numerous cells and cannot be attributed to the spike threshold of individual neurons. In the experiment a drastic increase in the firing level was observed upon increase of synaptic efficacy by lowering of the extracellular magnesium concentration, which is compatible with our theoretical predictions. This "on-off" phenomenon demonstrates that even in small neuronal ensembles collective behavior can emerge which is not explained by the characteristics of single neurons. PMID:8542966

  9. Strengthening of the Cooperative Framework for ANENT

    The Asian Network for Education in Nuclear Technology (ANENT) was established in February 2004 to promote nuclear education and training in Asia. Initially ANENT member countries cooperated with 5 group activities encompassing broad areas. As of 2006, the cooperative framework was strengthened in a way to focus on web-based nuclear education and training for a period of several years to come. In this context, the Nuclear Training Center (NTC) of KAERI has contributed, in particular, to the development of the ANENT web-portal including a cyber platform, and making available relevant courses and materials on the web-portal. This paper discusses details of the strengthened cooperative framework in terms of NTC's effort for realizing web-based education and training through regional networking

  10. Cooperative Learning i voksenundervisningen

    Wahlgren, Bjarne

    Nationalt Center for Kompetenceudvikling har evalueret undervisningsmetoden Cooperative Learning i voksenundervisningen og dokumenteret positive effekter på oplevelsen af samarbejde og på lærere og kursisters engagement - men har ikke kunnet påvise systematiske positive effekter af metoden på...... kursisters frafald, fravær og karakterer. Projektet har afprøvet og videreudviklet den pædagogiske metode Cooperative Learning (CL) i en dansk virkelighed og mere specifikt i forhold til VUC'ernes nye kursistgrupper med det overordnede mål at øge gennemførslen markant og målbart ved at anvende og udvikle en...

  11. Cooperation between employers

    Guidance is given on the application of the Ionising Radiations Regulations 1985 (IRR 85) and the Ionising Radiations (Outside Workers) Regulations 1993 (OWRs) in circumstances where the operations of the employees of one organisation have the potential to expose to ionising radiation the employees of another. One of the Regulations of IRR 85 makes it mandatory for employers to cooperate in such circumstances. OWRs give more detailed requirements for the performance of the duties where one employers' classified employee works in another employer's controlled area. This document explains the separate responsibilities of site operators and contractors in situations where cooperation is required, and gives guidance on how it can be achieved. It also gives guidance to nuclear site licence holders regarding their duties under IRR 85 in such circumstances. (Author)

  12. Strategies of inducing cooperation

    The results of the four experiments described in this paper are very consistent, and they can be summarized as follows: (1) The ''nonpunitive'' strategy was most effective in eliciting cooperative behavior from the subjects and, overall, resulted in the highest joint outcomes as well as the highest outcomes for the accomplice. (2) The effectiveness of the turn-the-other-cheek strategy was very much influenced by the competitiveness of the situation; the more competitive the incentives of the subjects, the more massively they exploited the accomplice who employed this strategy. (3) The punitive deterrent strategy elicited more agressive and self-protective, as well as less cooperative, behavior from the subjects than did the other strategies

  13. International cooperative information systems

    Developing countries need mechanisms by which the information they generate themselves and development information from the rest of the world can be retrieved. The international cooperative information system is such a mechanism. Delegates to the Seminar on International Cooperative Information Systems were informed about various existing systems (INIS, AGRIS, INFOTERRA, TCDC/INRES, POPIN, DEVSIS, and INPADROC), some specialized information systems and services (CDS/ISIS and the Cassava Information Centre), and computer programs for information processing (INIS/AGRIS, CDS/ISIS, and MINISIS). The participants suggested some changes that should be made on both the national and the international levels to ensure that these systems meet the needs of developing countries more effectively. (LL)

  14. Cooperative Retransmissions Through Collisions

    Qureshi, Jalaluddin; Foh, Chuan Heng

    2011-01-01

    Interference in wireless networks is one of the key capacity-limiting factors. Recently developed interference-embracing techniques show promising performance on turning collisions into useful transmissions. However, the interference-embracing techniques are hard to apply in practical applications due to their strict requirements. In this paper, we consider utilising the interference-embracing techniques in a common scenario of two interfering sender-receiver pairs. By employing opportunistic listening and analog network coding (ANC), we show that compared to traditional ARQ retransmission, a higher retransmission throughput can be achieved by allowing two interfering senders to cooperatively retransmit selected lost packets at the same time. This simultaneous retransmission is facilitated by a simple handshaking procedure without introducing additional overhead. Simulation results demonstrate the superior performance of the proposed cooperative retransmission.

  15. Nudging Cooperation in a Crowd Experiment

    Niella, Tamara; Stier-Moses, Nicolás; Sigman, Mariano

    2016-01-01

    We examine the hypothesis that driven by a competition heuristic, people don't even reflect or consider whether a cooperation strategy may be better. As a paradigmatic example of this behavior we propose the zero-sum game fallacy, according to which people believe that resources are fixed even when they are not. We demonstrate that people only cooperate if the competitive heuristic is explicitly overridden in an experiment in which participants play two rounds of a game in which competition is suboptimal. The observed spontaneous behavior for most players was to compete. Then participants were explicitly reminded that the competing strategy may not be optimal. This minor intervention boosted cooperation, implying that competition does not result from lack of trust or willingness to cooperate but instead from the inability to inhibit the competition bias. This activity was performed in a controlled laboratory setting and also as a crowd experiment. Understanding the psychological underpinnings of these behaviors may help us improve cooperation and thus may have vast practical consequences to our society. PMID:26797425

  16. IL-6 cooperates with peroxisome proliferator-activated receptor-alpha-ligands to induce liver fatty acid binding protein (LFABP) up-regulation

    Vida, Margarita; Serrano, Antonia; Romero-Cuevas, Miguel; Pavón, Francisco J.; González-Rodriguez, Águeda; Gavito, Ana L.; Cuesta, Antonio L.; Valverde, Ángela M.; Rodríguez de Fonseca, Fernando; Baixeras, Elena

    2013-01-01

    [Background]: LFABP plays a critical role in the uptake and intracellular transport of fatty acids (FA) and other peroxisome proliferator-activated receptor alpha (PPARα) ligands. PPARα activation by PPARα ligands bound to LFABP results in gene expression of FA oxidation enzymes and de novo LFABP. The cytokine IL-6 is involved in regulating liver lipid oxidation. [Aims]: To study the ability of IL-6 to modulate the expression of the LFABP in hepatocytes. Methods: HepG2 and mouse primary hepat...

  17. A Study on the Application of Cooperative Language Learning in the Spoken English Class of the University

    杨然

    2014-01-01

    Cooperative Language Learning(hereafter CLL)is one of the most widely used pedagogical theories, both in China and abroad. It emphasizes on the learner-centered teaching principle and makes maximum use of cooperative activities. Under the guidelines of the Cooperative Language Learning, this paper explores the application of cooperative language learning in the spoken English class of the university.

  18. Pioneers in Cooperation (selection)

    2004-01-01

    @@ Project-oriented cooperation within the framework of the CAS-MPSagreement began in the early 1980s. Its methods differed according to scientific needs and included workshops and seminars, field research, overland expeditions, exchanges of materials and samples, and the training of young scientists and engineers. The German Research Foundation and the National Natural Science Foundation of China provided special funding for many of these projects.

  19. Le banche popolari cooperative

    Schilirò, Daniele

    2011-01-01

    Co-operative banks are an important reality of the credit system and they are spread in Italy and in Europe. These banks are a category different from other banks, as are characterized by a legal form which has some very specific characteristics. These banks may contribute to the development of human capital and the strengthening of social capital, but also to the development of the knowledge economy that thrives on knowledge and tacit knowledge passed down through the local culture. This ess...

  20. Crisis-Driven Cooperation

    2009-01-01

    Not hit as badly as the West, East Asian and Southeast Asian countries grapple with the financial crisis from a long-term perspective Although Thailand postponed at the last minute the annual summits of East Asian and Southeast Asian leaders scheduled on April 11-12, regional cooperation will continue to forge ahead with full vigor, even more so in the context of the global financial crisis, said Chinese international studies experts.

  1. Quantized Cooperative Control

    Guo, Meng

    2011-01-01

    In this thesis project, we consider the cooperative control of multi-agent systems under limited communication between the individual agents. In particular, quantized values of the relatives states between neighboring agents are used as the control parameters for each agent. As an introductory part, the theoretical framework for the distributed consensus problem under perfect communication is reviewed with the focus on the system stability and convergence. We start from the common problem set...

  2. Chapter 11. International co-operation

    In this chapter the international co-operation of the Nuclear Regulatory Authority of the Slovak Republic (UJD) in 1999 is reviewed. The Director General of the IAEA, Mr. Mohamed ElBaradei by his deputy for nuclear safety, Mr. Zikmund Domaratsky, upon the invitation of Minister of Foreign Affairs of the Slovak Republic Mr. Eduard Kukan, on 29 and 30 April 1999. Since 1999 Slovakia is represented in the Board of Governors of the IAEA. The Chairman of UJD was delegated by the Government of Slovakia to take the function of the governor. Co-operation between Slovakia and the IAEA in the field of technical projects is very successful. In the past year Slovakia was involved in 6 national and 23 regional projects. Significant part of regional projects related to the nuclear safety. Overall UJD organized 6 seminars and training courses with a broad international participation. These focused on radiation protection, fuel cycle, emergency regulations and utilization of radiation methods in oncology. There were 15 active research contracts in the field of agriculture, nuclear energy, safety of nuclear installations, physics, chemistry and RAW in 1999. A medium-term goal of UJD in the field of technical co-operation is a gradual transition to active international assistance in providing assistance to less developed countries. Within the technical projects of the IAEA assistance has been provided mainly to the countries of former of former Soviet Union. Other international activities and co-operation of UJD in 1999 are presented

  3. Cooperative Mobile Web Browsing

    Zhang Q

    2009-01-01

    Full Text Available This paper advocates a novel approach for mobile web browsing based on cooperation among wireless devices within close proximity operating in a cellular environment. In the actual state of the art, mobile phones can access the web using different cellular technologies. However, the supported data rates are not sufficient to cope with the ever increasing traffic requirements resulting from advanced and rich content services. Extending the state of the art, higher data rates can only be achieved by increasing complexity, cost, and energy consumption of mobile phones. In contrast to the linear extension of current technology, we propose a novel architecture where mobile phones are grouped together in clusters, using a short-range communication such as Bluetooth, sharing, and accumulating their cellular capacity. The accumulated data rate resulting from collaborative interactions over short-range links can then be used for cooperative mobile web browsing. By implementing the cooperative web browsing on commercial mobile phones, it will be shown that better performance is achieved in terms of increased data rate and therefore reduced access times, resulting in a significantly enhanced web browsing user experience on mobile phones.

  4. International human cooperation in Japan Atomic Energy Research Institute

    Rearing of talented persons in the area of nuclear energy is one of the important works in Japan Atomic Energy Research Institute. In this report, the present situations and future schedules of international human cooperation in this area wsere summarized. First, the recent activities of International Nuclear Technology Center were outlined in respect of international human cooperation. A study and training course which was started in cooperation with JICA and IAEA from the middle of eighties and the international nuclear safety seminar aiming at advancing the nuclear safety level of the world are now being put into practice. In addition, a study and training for rearing talented persons was started from 1996 to improve the nuclear safety level of the neighbouring countries. The activities of the nuclear research interchange system by Science and Technology Agency established in 1985 and Bilateral Co-operation Agreement from 1984 were explained and also various difficulties in the international cooperation were pointed out. (M.N.)

  5. Genome-wide analysis reveals PADI4 cooperates with Elk-1 to activate c-Fos expression in breast cancer cells.

    Xuesen Zhang

    2011-06-01

    Full Text Available Peptidylarginine deiminase IV (PADI4 catalyzes the conversion of positively charged arginine and methylarginine residues to neutrally charged citrulline, and this activity has been linked to the repression of a limited number of target genes. To broaden our knowledge of the regulatory potential of PADI4, we utilized chromatin immunoprecipitation coupled with promoter tiling array (ChIP-chip analysis to more comprehensively investigate the range of PADI4 target genes across the genome in MCF-7 breast cancer cells. Results showed that PADI4 is enriched in gene promoter regions near transcription start sites (TSSs; and, surprisingly, this pattern of binding is primarily associated with actively transcribed genes. Computational analysis found potential binding sites for Elk-1, a member of the ETS oncogene family, to be highly enriched around PADI4 binding sites; and coimmunoprecipitation analysis then confirmed that Elk-1 physically associates with PADI4. To better understand how PADI4 may facilitate gene transactivation, we then show that PADI4 interacts with Elk-1 at the c-Fos promoter and that, following Epidermal Growth Factor (EGF stimulation, PADI4 catalytic activity facilitates Elk-1 phosphorylation, histone H4 acetylation, and c-Fos transcriptional activation. These results define a novel role for PADI4 as a transcription factor co-activator.

  6. Tracking Method of Space Non-cooperative Target with Active/Passive Fusion In-orbit%空间非合作目标在轨主/被动融合跟踪方法

    黄京梅; 胡士强

    2012-01-01

    For the problem of tracking long distance in-orbit non-cooperative point target, a synergy tracking algorithm of active/passive fusion system is given. Using Unscented Kalman Filter(UKF) algorithm based on passive sensor and intermittent-working mode of radar, the state information of non-cooperative target is established, using angle's measurements provided by the optical camera and intermittent range's measurements provided by the radar to estimate position and velocity of the target. The non-cooperative target's state information can use as the initial orbit data for autonomy space operations. Simulation results indicate that the point target can be tracking consciously based on UKF algorithm when the state error and measurement noise are changing, and intermittent range information provided by radar can get better tracking accuracy.%针对空间远距离非合作目标的点目标跟踪问题,研究基于非地面测控数据支持的远距离空间目标的在轨主/被动融合跟踪方法.包括运用基于被动传感器以及雷达间歇辅助测距跟踪的Unscented卡尔曼滤波(UKF)方法,得到非合作目标的运动状态信息,即利用光学跟踪摄像机的二维角度量测值及雷达间歇提供的距离量测值,估计目标的惯性位置与速度方法,为后续自主空间操作建立初始轨道状态数据.仿真结果表明,当状态误差和量测噪声改变时,UKF均能持续跟踪远距离非合作目标,使得雷达间歇提供的距离信息可以得到更好的跟踪精度.

  7. 机载雷达与红外协同资源管理技术%Technology of the Cooperative Resource Management for Airborne Active Radar and Passive IR

    薛朝晖; 周文辉; 李元平

    2012-01-01

    为了解决机载雷达与红外协同资源管理问题,提出了以单个控制因子设定协方差门限的有源雷达辐射控制方法.该方法原理简单,易于工程实现.文中以两机编队为研究实例,分析了机动目标跟踪背景下的有源资源管理效果.结果表明,控制因子越小,有源照射次数越多,跟踪误差越小.%To solve the problem of cooperative resource management for the airborne active radar and passive IR, a new method which uses only one control factor to define the covariance threshold is presented. The principle of this new method for radiation control is simple and easy to implement practically. The effects of active resource management are validated by the simulations of nonmaneuvering and maneuvering targets with an example of two fighters. The results show that the smaller control factor, the more active radiation times, and the smaller tracking accuracy of the position.

  8. Regional activity on safe management of radioactive waste under the framework of the Forum for Nuclear Co-operation in Asia (FNCA)

    Nine Asian countries including Australia are participating in various projects among 8 fields under the framework of FNCA. Radioactive Waste Management (RWM) project is one of these projects. Annual workshop provides to member states a good and informative platform for enhancing improvement of good and safe management of radioactive waste. Through the past activities, this project published three reports, namely 'RWM Consolidated Report', 'SRSM Activity Report', and 'Activity Report of TENORM Task Group'. RWM Newsletters are published twice a year, and provide a good information and communication among member states, too. Further, an internet communication through FNCA web-site is a good tool for mutual understanding and sends messages not only to FNCA RWM colleagues, but also to other international organizations. (author)

  9. Coalitions in Cooperative Wireless Networks

    Mathur, Suhas; Mandayam, Narayan B

    2008-01-01

    Cooperation between rational users in wireless networks is studied using coalitional game theory. Using the rate achieved by a user as its utility, it is shown that the stable coalition structure, i.e., set of coalitions from which users have no incentives to defect, depends on the manner in which the rate gains are apportioned among the cooperating users. Specifically, the stability of the grand coalition (GC), i.e., the coalition of all users, is studied. Transmitter and receiver cooperation in an interference channel (IC) are studied as illustrative cooperative models to determine the stable coalitions for both flexible (transferable) and fixed (non-transferable) apportioning schemes. It is shown that the stable sum-rate optimal coalition when only receivers cooperate by jointly decoding (transferable) is the GC. The stability of the GC depends on the detector when receivers cooperate using linear multiuser detectors (non-transferable). Transmitter cooperation is studied assuming that all receivers coopera...

  10. Collective-goal ascription increases cooperation in humans.

    Panagiotis Mitkidis

    Full Text Available BACKGROUND: Cooperation is necessary in many types of human joint activity and relations. Evidence suggests that cooperation has direct and indirect benefits for the cooperators. Given how beneficial cooperation is overall, it seems relevant to investigate the various ways of enhancing individuals' willingness to invest in cooperative endeavors. We studied whether ascription of a transparent collective goal in a joint action promotes cooperation in a group. METHODS: A total of 48 participants were assigned in teams of 4 individuals to either a "transparent goal-ascription" or an "opaque goal-ascription" condition. After the manipulation, the participants played an anonymous public goods game with another member of their team. We measured the willingness of participants to cooperate and their expectations about the other player's contribution. RESULTS: Between subjects analyses showed that transparent goal ascription impacts participants' likelihood to cooperate with each other in the future, thereby greatly increasing the benefits from social interactions. Further analysis showed that this could be explained with a change in expectations about the partner's behavior and by an emotional alignment of the participants. CONCLUSION: The study found that a transparent goal ascription is associated with an increase of cooperation. We propose several high-level mechanisms that could explain the observed effect: general affect modulation, trust, expectation and perception of collective efficacy.

  11. A study on the establishment of nuclear cooperative relations and future direction between Korea and Egypt

    Yang, M. H.; Kim, H. S.; Kim, H. J.; Yun, S. W.; Ko, H. S

    2000-10-01

    This study was carried out in order to review the cooperation with Egypt and establish and activate the cooperative relations with Egypt. Recent policy trends in the use and development of nuclear energy in Egypt, were investigated including introduction of nuclear power plant, and cooperative relations between two nations were also established under the implementation of the project. It was agreed through exchanges of visits of nuclear cooperation delegation; 1) exchange of visits of cooperation delegation, 2) invitation of egypt experts to policy seminar 3) cooperation between relevant nuclear related organizations of two countries, 4) future cooperation fields and directions between two countries. It is recommended that cooperation with Egypt be implemented systematically through the long term based on national basic cooperation directions and integrated strategies.

  12. A study on the establishment of nuclear cooperative relations and future direction between Korea and Egypt

    This study was carried out in order to review the cooperation with Egypt and establish and activate the cooperative relations with Egypt. Recent policy trends in the use and development of nuclear energy in Egypt, were investigated including introduction of nuclear power plant, and cooperative relations between two nations were also established under the implementation of the project. It was agreed through exchanges of visits of nuclear cooperation delegation; 1) exchange of visits of cooperation delegation, 2) invitation of egypt experts to policy seminar 3) cooperation between relevant nuclear related organizations of two countries, 4) future cooperation fields and directions between two countries. It is recommended that cooperation with Egypt be implemented systematically through the long term based on national basic cooperation directions and integrated strategies

  13. We can work it out: An enactive look at cooperation

    ValentinaFantasia

    2014-08-01

    Full Text Available The past years have seen an increasing debate on cooperation and its unique human character. Philosophers and psychologists have proposed that cooperative activities are characterized by shared goals to which participants are committed through the ability to understand each other’s intentions. Despite its popularity, some serious issues arise with this approach to cooperation. First, one may challenge the assumption that high-level mental processes are necessary for engaging in acting cooperatively. If they are, then how do agents that do not possess such ability (preverbal children, or children with autism who are often claimed to be mind-blind engage in cooperative exchanges, as the evidence suggests? Secondly, to define cooperation as the result of two de-contextualized minds reading each other’s intentions may fail to fully acknowledge the complexity of situated, interactional dynamics and the interplay of variables such as the participants’ relational and personal history and experience. In this paper we challenge such accounts of cooperation, calling for an embodied approach that sees cooperation not only as an individual attitude towards the other, but also as a property of interaction processes. Taking an enactive perspective, we argue that cooperation is an intrinsic part of any interaction, and that there can be cooperative interaction before complex communicative abilities are achieved. The issue then is not whether one is able or not to read the other’s intentions, but what it takes to participate in joint action. From this basic account, it should be possible to build up more complex forms of cooperation as needed. Addressing the study of cooperation in these terms may enhance our understanding of human social development, and foster our knowledge of different ways of engaging with others, as in the case of autism.

  14. We can work it out: an enactive look at cooperation.

    Fantasia, Valentina; De Jaegher, Hanne; Fasulo, Alessandra

    2014-01-01

    The past years have seen an increasing debate on cooperation and its unique human character. Philosophers and psychologists have proposed that cooperative activities are characterized by shared goals to which participants are committed through the ability to understand each other's intentions. Despite its popularity, some serious issues arise with this approach to cooperation. First, one may challenge the assumption that high-level mental processes are necessary for engaging in acting cooperatively. If they are, then how do agents that do not possess such ability (preverbal children, or children with autism who are often claimed to be mind-blind) engage in cooperative exchanges, as the evidence suggests? Secondly, to define cooperation as the result of two de-contextualized minds reading each other's intentions may fail to fully acknowledge the complexity of situated, interactional dynamics and the interplay of variables such as the participants' relational and personal history and experience. In this paper we challenge such accounts of cooperation, calling for an embodied approach that sees cooperation not only as an individual attitude toward the other, but also as a property of interaction processes. Taking an enactive perspective, we argue that cooperation is an intrinsic part of any interaction, and that there can be cooperative interaction before complex communicative abilities are achieved. The issue then is not whether one is able or not to read the other's intentions, but what it takes to participate in joint action. From this basic account, it should be possible to build up more complex forms of cooperation as needed. Addressing the study of cooperation in these terms may enhance our understanding of human social development, and foster our knowledge of different ways of engaging with others, as in the case of autism. PMID:25152745

  15. A cooperative water effect in proazaphosphatrane-catalysed heterocycle synthesis.

    Honey, Mark A; Yamashita, Yasuhiro; Kobayashi, Shū

    2014-03-28

    The synthesis of oxazolines and imidazolines was achieved by activation of isocyanides with water. Mechanistic studies show that the organosuperbase proazaphosphatrane is tolerant of water within the reaction medium, with a beneficial and cooperative effect being observed. PMID:24525763

  16. International Cooperation on Radioactive Source Security in South East Asia

    The paper describes international technical cooperation and assistance in South East Asia on the establishment, implementation, maintenance and sustainability of radioactive source security measures for the prevention of unauthorized acquisition of, or access to, high activity radioactive sources. (author)

  17. Re-expression of GATA2 Cooperates with Peroxisome Proliferator-activated Receptor-γ Depletion to Revert the Adipocyte Phenotype*S⃞

    Schupp, Michael; Cristancho, Ana G; Lefterova, Martina I.; Hanniman, Elyisha A.; Briggs, Erika R.; Steger, David J; Qatanani, Mohammed; Curtin, Joshua C.; Schug, Jonathan; Ochsner, Scott A.; McKenna, Neil J; Lazar, Mitchell A.

    2009-01-01

    Nuclear peroxisome proliferator-activated receptor-γ (PPARγ) is required for adipocyte differentiation, but its role in mature adipocytes is less clear. Here, we report that knockdown of PPARγ expression in 3T3-L1 adipocytes returned the expression of most adipocyte genes to preadipocyte levels. Consistently, down-regulated but not up-regulated genes showed strong enrichment of PPARγ binding. Surprisingly, not all adipocyte genes were reversed, and the adipocyte morpho...

  18. Cooperative Learning Instructional Methods for CS1: Design, Implementation, and Evaluation

    Beck, Leland; Chizhik, Alexander

    2013-01-01

    Cooperative learning is a well-known instructional technique that has been applied with a wide variety of subject matter and a broad spectrum of populations. This article briefly reviews the principles of cooperative learning, and describes how these principles were incorporated into a comprehensive set of cooperative learning activities for a CS1…

  19. 75 FR 71079 - Determination on Use of Cooperative Threat Reduction Funds in Pakistan and Afghanistan Under...

    2010-11-22

    ... of the Secretary Determination on Use of Cooperative Threat Reduction Funds in Pakistan and... Defense has determined that the obligation and expenditure of Cooperative Threat Reduction (CTR) funds for... further determined that these cooperative threat reduction activities will be completed within a...

  20. AFRA: Supporting regional cooperation

    The African Regional Cooperative Agreement for Research, Development and Training Related to Nuclear Science and Technology (AFRA) provides a framework for African Member States to intensify their collaboration through programmes and projects focused on the specific shared needs of its members. It is a formal intergovernmental agreement which entered into force in 1990. In the context of AFRA, Regional Designated Centres for training and education in radiation protection (RDCs) are established African institutions able to provide services, such as training of highly qualified specialists or instructors needed at the national level and also to facilitate exchange of experience and information through networks of services operating in the field

  1. Cooperation Between Equals

    2011-01-01

    2011 MARKS the 55th anniversary of the start of contemporary friendly relations between the People’s Republic of China and African countries. Chinese Vice Premier Hui Liangyu’s recent African trip gave another boost to the burgeoning China-Africa ties,said Chinese Vice Foreign Minister Zhai Jun.Hui visited five African countries - Mauritius, Zambia,the Democratic Republic of the Congo,Cameroon and Senegal -from January 6 to 19.Agriculture and trade were some of the most promising areas of cooperation between China and these countries,said Zhai in a recent interview with ChinAfrica.Excerpts follow:

  2. Cooperative problem solving in a cooperatively breeding primate

    Cronin, K.; Kurian, A; Snowdon, C

    2005-01-01

    We investigated cooperative problem solving in unrelated pairs of the cooperatively breeding cottontop tamarin, Saguinus oedipus, to assess the cognitive basis of cooperative behaviour in this species and to compare abilities with other apes and monkeys. A transparent apparatus was used that required extension of two handles at opposite ends of the apparatus for access to rewards. Resistance was applied to both handles so that two tamarins had to act simultaneously in order to receive rewards...

  3. Cooperative problem solving in a cooperatively breeding primate (Saguinus oedipus)

    Cronin, Katherine A.; KURIAN, AIMEE V.; Snowdon, Charles T.

    2005-01-01

    We investigated cooperative problem solving in unrelated pairs of the cooperatively breeding cottontop tamarin, Saguinus oedipus, to assess the cognitive basis of cooperative behaviour in this species and to compare abilities with other apes and monkeys. A transparent apparatus was used that required extension of two handles at opposite ends of the apparatus for access to rewards. Resistance was applied to both handles so that two tamarins had to act simultaneously in order to receive rewards...

  4. High-throughput combinatorial screening identifies drugs that cooperate with ibrutinib to kill activated B-cell-like diffuse large B-cell lymphoma cells.

    Mathews Griner, Lesley A; Guha, Rajarshi; Shinn, Paul; Young, Ryan M; Keller, Jonathan M; Liu, Dongbo; Goldlust, Ian S; Yasgar, Adam; McKnight, Crystal; Boxer, Matthew B; Duveau, Damien Y; Jiang, Jian-Kang; Michael, Sam; Mierzwa, Tim; Huang, Wenwei; Walsh, Martin J; Mott, Bryan T; Patel, Paresma; Leister, William; Maloney, David J; Leclair, Christopher A; Rai, Ganesha; Jadhav, Ajit; Peyser, Brian D; Austin, Christopher P; Martin, Scott E; Simeonov, Anton; Ferrer, Marc; Staudt, Louis M; Thomas, Craig J

    2014-02-11

    The clinical development of drug combinations is typically achieved through trial-and-error or via insight gained through a detailed molecular understanding of dysregulated signaling pathways in a specific cancer type. Unbiased small-molecule combination (matrix) screening represents a high-throughput means to explore hundreds and even thousands of drug-drug pairs for potential investigation and translation. Here, we describe a high-throughput screening platform capable of testing compounds in pairwise matrix blocks for the rapid and systematic identification of synergistic, additive, and antagonistic drug combinations. We use this platform to define potential therapeutic combinations for the activated B-cell-like subtype (ABC) of diffuse large B-cell lymphoma (DLBCL). We identify drugs with synergy, additivity, and antagonism with the Bruton's tyrosine kinase inhibitor ibrutinib, which targets the chronic active B-cell receptor signaling that characterizes ABC DLBCL. Ibrutinib interacted favorably with a wide range of compounds, including inhibitors of the PI3K-AKT-mammalian target of rapamycin signaling cascade, other B-cell receptor pathway inhibitors, Bcl-2 family inhibitors, and several components of chemotherapy that is the standard of care for DLBCL. PMID:24469833

  5. The enzymes LSD1 and Set1A cooperate with the viral protein HBx to establish an active hepatitis B viral chromatin state

    Alarcon, Valentina; Hernández, Sergio; Rubio, Lorena; Alvarez, Francisca; Flores, Yvo; Varas-Godoy, Manuel; De Ferrari, Giancarlo V.; Kann, Michael; Villanueva, Rodrigo A.; Loyola, Alejandra

    2016-01-01

    With about 350 million people chronically infected around the world hepatitis B is a major health problem. Template for progeny HBV synthesis is the viral genome, organized as a minichromosome (cccDNA) inside the hepatocyte nucleus. How viral cccDNA gene expression is regulated by its chromatin structure; more importantly, how the modulation of this structure impacts on viral gene expression remains elusive. Here, we found that the enzyme SetDB1 contributes to setting up a repressed cccDNA chromatin state. This repressive state is activated by the histone lysine demethylase-1 (LSD1). Consistently, inhibiting or reducing LSD1 levels led to repression of viral gene expression. This correlates with the transcriptionally repressive mark H3K9 methylation and reduction on the activating marks H3 acetylation and H3K4 methylation on viral promoters. Investigating the importance of viral proteins we found that LSD1 recruitment to viral promoters was dependent on the viral transactivator protein HBx. Moreover, the histone methyltransferase Set1A and HBx are simultaneously bound to the core promoter, and Set1A expression correlates with cccDNA H3K4 methylation. Our results shed light on the mechanisms of HBV regulation mediated by the cccDNA chromatin structure, offering new therapeutic targets to develop drugs for the treatment of chronically infected HBV patients. PMID:27174370

  6. The enzymes LSD1 and Set1A cooperate with the viral protein HBx to establish an active hepatitis B viral chromatin state.

    Alarcon, Valentina; Hernández, Sergio; Rubio, Lorena; Alvarez, Francisca; Flores, Yvo; Varas-Godoy, Manuel; De Ferrari, Giancarlo V; Kann, Michael; Villanueva, Rodrigo A; Loyola, Alejandra

    2016-01-01

    With about 350 million people chronically infected around the world hepatitis B is a major health problem. Template for progeny HBV synthesis is the viral genome, organized as a minichromosome (cccDNA) inside the hepatocyte nucleus. How viral cccDNA gene expression is regulated by its chromatin structure; more importantly, how the modulation of this structure impacts on viral gene expression remains elusive. Here, we found that the enzyme SetDB1 contributes to setting up a repressed cccDNA chromatin state. This repressive state is activated by the histone lysine demethylase-1 (LSD1). Consistently, inhibiting or reducing LSD1 levels led to repression of viral gene expression. This correlates with the transcriptionally repressive mark H3K9 methylation and reduction on the activating marks H3 acetylation and H3K4 methylation on viral promoters. Investigating the importance of viral proteins we found that LSD1 recruitment to viral promoters was dependent on the viral transactivator protein HBx. Moreover, the histone methyltransferase Set1A and HBx are simultaneously bound to the core promoter, and Set1A expression correlates with cccDNA H3K4 methylation. Our results shed light on the mechanisms of HBV regulation mediated by the cccDNA chromatin structure, offering new therapeutic targets to develop drugs for the treatment of chronically infected HBV patients. PMID:27174370

  7. Cooperative ways of learning at environmental studies in the second class

    Urbas, Marija

    2011-01-01

    The theoretical part of the diploma entitled Cooperative ways of learning at environmental studies in the second class presents different ways of cooperative learning, especially those that can be taught at social studies in the first three-year education period. The diploma highlights the principles that have to be taken into account to form groups to carry out the cooperative ways of learning. The taxonomies that help a teacher prepare the questions and activities for cooperative learning a...

  8. Cross-border cooperation in tourism between the Warmian-Masurian voivodeship and the Kaliningrad region

    Batyk Iwona; Semenova Lyudmila

    2013-01-01

    The border location of the Warmian-Masurian voivodeship and the Kaliningrad region is a prerequisite for active cooperation at different institutional levels. The development of cross-border cooperation between the Kaliningrad region and the Warmian-Masurian voivodeship was launched in 1992, when the first agreements on international cooperation were signed. As of today, a high emphasis is placed on cross-border cooperation between the Warmian-Masurian voivodeship and the Kaliningrad region, ...

  9. Teleworking through cooperation

    Dario Minervini

    2006-07-01

    scheme is strictly connected to new technologies and cooperation is an important dimension of teleworking. In our study, cooperation is found performed both in social relations between employers and employees and in institutionalized relations between managers and unions. Although the two forms of cooperation, here called “social trustee cooperation” and “institutional cooperation”, are often thought as prerequisites of “best practices” of new working arrangements, our case studies demonstrate that cooperation has not always arisen that make possible to implement practices of teleworking. By focusing on cooperative relations, the results of different case studies in industry and in the service sector are discussed, thus intending to contribute to the development of sociological debate on telework.

  10. A Cooperation-Based Fault Management Method for Satellite Networks

    Wenbo Zhang

    2012-07-01

    Full Text Available In order to efficiently diagnose the satellite network, a three level management architecture was proposed and a cooperated-based fault management method was put forward. In this method the traditional fault management method was used through network management technique when a satellite agent could respond to the network management instruction received from the management station. However, if the satellite agent could not respond to the network management demands, the intra-domain cooperation or inter-domain cooperation would be activated. The suspected fault satellite could be tested through cooperation among the satellite agents. The simulation results shows that in the circumstance of the low faulty frequency, the new method could be effectively used in satellite network with short cooperative time and low throughput.

  11. Better Together: Outcomes of Cooperation Versus Competition in Social Exergaming.

    Marker, Arwen M; Staiano, Amanda E

    2015-02-01

    Children and adolescents most often play active videogames, or exergames, in a social environment. Social play may enhance the potential benefits of an exergaming experience, much like group exercise and team sports are observed to improve physical activity-related outcomes above those of solitary exercise. Two ubiquitous elements of exergames are cooperation and competition. Previous literature suggests that cooperative and competitive aspects of exergames may affect physiological and psychosocial changes. Competitive play has been found to increase energy expenditure and aggression in short bouts of exergaming. Cooperative exergaming has been found to increase motivation, promote continued play, enhance self-efficacy, and increase pro-social behaviors. In one study, a cooperative exergaming condition also resulted in significant weight loss for overweight and obese adolescents. Individual player differences such as individual preferences, competitiveness, weight status, age, gender, and ethnicity may moderate effects. Although the current volume of literature on competition and cooperation in exergaming is small, social exergames hold promise as an engaging alternative to traditional physical activity interventions and may promote a broad range of positive outcomes for children and adolescents. Principles of cooperation and competition are applicable for developers of health-promoting games. Future research is needed to further understand the mechanisms of how competition and cooperation in social exergaming impact physiological and psychosocial outcomes. PMID:26181677

  12. The Professionalization of Intelligence Cooperation

    Svendsen, Adam David Morgan

    "Providing an in-depth insight into the subject of intelligence cooperation (officially known as liason), this book explores the complexities of this process. Towards facilitating a general understanding of the professionalization of intelligence cooperation, Svendsen's analysis includes risk...... management and encourages the realisation of greater resilience. Svendsen discusses the controversial, mixed and uneven characterisations of the process of the professionalization of intelligence cooperation and argues for a degree of 'fashioning method out of mayhem' through greater operational...

  13. Social learning in cooperative dilemmas

    Lamba, Shakti

    2014-01-01

    Helping is a cornerstone of social organization and commonplace in human societies. A major challenge for the evolutionary sciences is to explain how cooperation is maintained in large populations with high levels of migration, conditions under which cooperators can be exploited by selfish individuals. Cultural group selection models posit that such large-scale cooperation evolves via selection acting on populations among which behavioural variation is maintained by the cultural transmission ...

  14. Cooperation bibliogram of bird flu

    Stegmann, Johannes; Grohmann, Guenter

    2006-01-01

    The published literature on Bird Flu, now a pandemic animal disease with a possible potential of evolving into a devastating human disease, was analysed primarily with respect of national and international cooperations and networks of authors and countries. The output of research-relevant papers is now around 150 per year and was less than 100 papers per year before 2003. The field is highly cooperative; nearly 90% of the articles have two or more authors. National extramural cooperation is ...

  15. ITDB Cooperation With International Organizations

    IAEA illicit trafficking database cooperates with many international organizations. Among these organizations are Interpol, Universal Postal Union,and World Customs Organization. Other organizations are Organization for Security and Cooperation in Europe, UN Economic Commission for Europe, UN-Department of Disarmament Affairs and UN office for Drug and Crime. The cooperation with Interpol involves consultations on issues of training and technical assistance and other matters of common interest.

  16. PROSPECTS FOR AGRICULTURAL COOPERATIVES IN ROMANIA IN THE CONTEXT OF CAP REFORM 2014-2020

    Maria Magdalena TUREK RAHOVEANU

    2012-01-01

    Full Text Available European and global cooperative sector is a powerful economic and social actors within these societies, with significant results can be summarized as market shares both in their work and contribution to GDP and the number of members and the welfare of citizens offered through job creation. Global cooperative activity operates on cooperative principles cooperative companies regularly reviewed by members of the International Cooperative Alliance (ICA. This cooperative movement worldwide organization founded in 1889, is composed of 226 active cooperatives in all sectors of the economy that brings together more than 800 million members in 89 countries. This work is part of the CAP reform in Europe after 2013, by which Romania will have to undergo a series of transformations including: promoting and encouraging cooperation and association in agriculture; stimulate the development of alternative economic activities such as organic farming, ecotourism, development and promotion of local products labeled specialized human capital development and collaboration and sharing of best practices with experts from other EU Member States. Macroeconomic paper wants to answer a series of questions: Is a viable alternative for Agricultural Cooperative Farm? What is the economic and social impact of cooperatives in the next stage? Through agricultural cooperatives can better penetrate markets closer to the consumer? What is the specific model of cooperation forward Romanian society?

  17. Cooperative usages of radon facilities

    Outlined are the structure and activity of the Radon Facilities, which, partly two storied, consists of a total floor space of about 300 m2 and is characteristic of high-ceilinged rooms. In the controlled area of the first floor, there are rooms of radium for radon source, sham environmental laboratory having the standard radon chamber of inner volume of 25 m3, monitoring room, etc. Radium is sintered in porous ceramic fiber so as to efficiently and stably release radon. In the radon chamber, W 3610 x D 2720 x H 2500 mm/controllable temperature of 5-30 deg. C and humidity of 30-90%, exposure to the constant level of radon is possible, of which reliability of absolute measurement by an ionization chamber, AlphaGUARD, is assured by periodical correction primarily in National Institute of Radiological Sciences (NIRS) and secondarily by Physikalische-Technische Bundesanstalt (Germany). The reliability has been also assured by cooperative comparative experiments with 6 Japanese facilities and 10 abroad. Decay products of radon for exposure are adsorbed on aerosol yielded from Sinclair-Lamer condensing particulate generator. In 2008, cooperative studies have been done with Niigata University of development of atmospheric radon/thoron measurement system with use of Cherenkov radiation, and with Tokyo University for calibration of measurement system of levels of radon, thoron and their decay products. Other non-controlled area includes a preparatory laboratory, a room for data analysis, etc. And on the second floor, air conditioning machineries for air supply and exhaust. (T.T.)

  18. Establishment of a Nuclear Cooperation Network between Korea and Brazil

    The objective of this study is to establish a personnel network and to identify potential complementary areas for technical cooperation in the future to advance Korean-Brazilian nuclear cooperation activities. To this end, current status of the cooperation in the areas of economy, energy resources and S and T between the two countries was surveyed, and the history of the nuclear development program and the current nuclear R and D status in Brazil, as well as the bilateral nuclear cooperation activities of both countries were analyzed. In addition, areas of mutual interest were identified by both countries' focal points and a personnel network was established. Based on the aforementioned preliminary activities, bilateral joint seminars were held in Brazil. At the joint seminars, possible areas of cooperation were discussed and joint research collaboration areas were surveyed and identified while both sides made efforts to expand the information and experts exchanges in specific areas. Through this study, possible specific areas of cooperation in which both sides have a common interest were identified in such areas as radiation technology application, post irradiation examination, radioactive waste management, I and C, and advanced nuclear fuel, and also concrete implementation methods were proposed. These results will be effectively utilized in establishing a basic direction for expanding bilateral nuclear cooperation activities in the future. Consistent establishment of a foundation for promoting cooperation could be established and maintained through the operation of a focal point in charge of coordinating bilateral technical cooperation, and then a long-term and stable human network could be established

  19. Establishment of a Nuclear Cooperation Network between Korea and Brazil

    Kim, Kyoung Pyo; Sohn, Dong Seong; Song, Kee Chan (and others)

    2008-03-15

    The objective of this study is to establish a personnel network and to identify potential complementary areas for technical cooperation in the future to advance Korean-Brazilian nuclear cooperation activities. To this end, current status of the cooperation in the areas of economy, energy resources and S and T between the two countries was surveyed, and the history of the nuclear development program and the current nuclear R and D status in Brazil, as well as the bilateral nuclear cooperation activities of both countries were analyzed. In addition, areas of mutual interest were identified by both countries' focal points and a personnel network was established. Based on the aforementioned preliminary activities, bilateral joint seminars were held in Brazil. At the joint seminars, possible areas of cooperation were discussed and joint research collaboration areas were surveyed and identified while both sides made efforts to expand the information and experts exchanges in specific areas. Through this study, possible specific areas of cooperation in which both sides have a common interest were identified in such areas as radiation technology application, post irradiation examination, radioactive waste management, I and C, and advanced nuclear fuel, and also concrete implementation methods were proposed. These results will be effectively utilized in establishing a basic direction for expanding bilateral nuclear cooperation activities in the future. Consistent establishment of a foundation for promoting cooperation could be established and maintained through the operation of a focal point in charge of coordinating bilateral technical cooperation, and then a long-term and stable human network could be established.

  20. Successful Industry/Academia Cooperation

    Stoustrup, Jakob

    2013-01-01

    The control literature is rich on impressive applications of advanced control, and within almost any industrial sector there are numerous examples of successful advanced control applications. Nevertheless, there is a widespread belief that there is still a wide potential for increased cooperation...... between academia and industry within this area. In this position paper, it is advocated that one of the enablers for successful cooperation between industry and academia within the control area is a proper framework for cooperation projects between companies and universities. Some suggestions...... by less complex but industrially feasible solutions. The proposed approach is illustrated by three case studies of successful industrial/academic cooperation....

  1. Mechanisms for similarity based cooperation

    Traulsen, A.

    2008-06-01

    Cooperation based on similarity has been discussed since Richard Dawkins introduced the term “green beard” effect. In these models, individuals cooperate based on an aribtrary signal (or tag) such as the famous green beard. Here, two different models for such tag based cooperation are analysed. As neutral drift is important in both models, a finite population framework is applied. The first model, which we term “cooperative tags” considers a situation in which groups of cooperators are formed by some joint signal. Defectors adopting the signal and exploiting the group can lead to a breakdown of cooperation. In this case, conditions are derived under which the average abundance of the more cooperative strategy exceeds 50%. The second model considers a situation in which individuals start defecting towards others that are not similar to them. This situation is termed “defective tags”. It is shown that in this case, individuals using tags to cooperate exclusively with their own kind dominate over unconditional cooperators.

  2. Investigating Cooperative Behavior in Ecological Settings: An EEG Hyperscanning Study

    Petti, Manuela; He, Eric J.; De Giusti, Vittorio; He, Bin; Astolfi, Laura; Babiloni, Fabio

    2016-01-01

    The coordinated interactions between individuals are fundamental for the success of the activities in some professional categories. We reported on brain-to-brain cooperative interactions between civil pilots during a simulated flight. We demonstrated for the first time how the combination of neuroelectrical hyperscanning and intersubject connectivity could provide indicators sensitive to the humans’ degree of synchronization under a highly demanding task performed in an ecological environment. Our results showed how intersubject connectivity was able to i) characterize the degree of cooperation between pilots in different phases of the flight, and ii) to highlight the role of specific brain macro areas in cooperative behavior. During the most cooperative flight phases pilots showed, in fact, dense patterns of interbrain connectivity, mainly linking frontal and parietal brain areas. On the contrary, the amount of interbrain connections went close to zero in the non-cooperative phase. The reliability of the interbrain connectivity patterns was verified by means of a baseline condition represented by formal couples, i.e. pilots paired offline for the connectivity analysis but not simultaneously recorded during the flight. Interbrain density was, in fact, significantly higher in real couples with respect to formal couples in the cooperative flight phases. All the achieved results demonstrated how the description of brain networks at the basis of cooperation could effectively benefit from a hyperscanning approach. Interbrain connectivity was, in fact, more informative in the investigation of cooperative behavior with respect to established EEG signal processing methodologies applied at a single subject level. PMID:27124558

  3. Priming Cooperation in Social Dilemma Games

    Drouvelis, Michalis; Metcalfe, Robert; Powdthavee, Nattavudh

    2010-01-01

    Research on public goods mainly focuses its attention on the ability of incentives, beliefs and group structure to affect behaviour in social dilemma interactions. This paper investigates the pure effects of a rather subtle mechanism on social preferences in a one-shot linear public good game. Using priming techniques from social psychology, we activate the concept of cooperation and explore the extent to which this intervention brings about changes in people's voluntary contributions to the ...

  4. Games of confidence and cooperation among children

    Žemljič, Martina

    2012-01-01

    Each day we are more and more aware of the importance of the child's social development, to which teachers in kindergarten can have a major impact. I believe, that these are activities of dancing and moving, those that lead children to various interactions and influence on mutual confidence and cooperation – the social integration of children. In the first part of the thesis I have identified and described the socialization process and the factors that have a major impact on children's s...

  5. Group-awareness for mobile cooperative learning.

    Meseguer Pallarès, Roc; Navarro Moldes, Leandro; Reyes Muñoz, María Angélica

    2006-01-01

    Collaborative learning traditionally relies on the arrangement of space and physical artifacts to mediate group activities. Our claim is that CSCL environments should enhance collaborative learning in a complementary way without introducing additional burden to human participants. This paper present research results on how tracking the location of people could be used to incorporate automatic group awareness in existing and new CSCL applications that support mobile cooperative learning. After...

  6. Sales Promotion and Cooperative Retail Pricing Strategies

    Richards, Timothy J.; Patterson, Paul M.

    2004-01-01

    Supermarket retailers make strategic pricing decisions in a high-frequency, repeated game environment both in buying and selling fresh produce. In this context, there is some question as to whether a non-cooperative equilibrium can emerge that produces margins above the competitive level. Supermarket pricing results from tacitly collusive equilibria supported by trigger price strategies played in upstream markets. Upstream activities are, in turn, driven by periodic retail price promotions. W...

  7. Collaborative Practices in Bilingual Cooperative Learning Classrooms

    Gumperz, John; Cook-Gumperz, Jenny; Szymanski, Margaret

    1999-01-01

    It is by now well established that self-organized acts of learning can have important long-term cognitive benefits. The many programs of cooperative learning, while they vary in detail, all agree that participants must actively work together for such benefits to be realized (Cohen, 1990). Further, because cognitive change is revealed through the ways in which learners' sense of ownership and control over their intellectual products is increased over time, the changes are not easily observed a...

  8. International cooperation and exchange

    For improve the nuclear safety regulatory level of China, it is an important way to absorb international experience widely and use them. In 1998, the NNSA dispatched abroad 34 delegations/90 person-time, and invited to China 9 delegations/73 person-time. The contents of dispatched delegations mainly included the international meetings and personnel training on nuclear safety, and the foreign review consultation and the components' manufacturing inspections related to Chinese nuclear power construction. The contents of invited delegations mainly included the lectures on surveillance technology, and the review consultation about the QSNPP's component purchase from several countries, JLNPP and CEFR. After reformed, the NNSA continues to bear the function on the international cooperation about nuclear safety

  9. EL CONTROL DE LA ACTIVIDAD REGISTRAL COOPERATIVA: ESTUDIO CRÍTICO SOBRE SUS DIFICULTADES E INCÓGNITAS/THE CONTROL OF THE REGISTRAL ACTIVITY ON CO-OPERATIVES: A CRITICAL STUDY OF ITS DIFFICULTIES AND ENIGMAS

    María BURZACO SAMPER

    2009-09-01

    Full Text Available La configuración de los Registros de Cooperativas como instrumentos de carácter administrativo con eficacia jurídica encierra una serie de dificultades de indudable trascendencia práctica entre los que destaca el control de la actividad registral. En este sentido, la multiplicidad normativa característica del actual escenario jurídico cooperativo propicia la existencia de soluciones divergentes que, al margen de los problemas que plantean sobre un eventual exceso competencial, pueden tener incidencia tanto en la seguridad jurídica como en el tipo y alcance de la fiscalización judicial. Por otro lado, la naturaleza híbrida de los Registros de Cooperativas provoca distorsiones cuya salida no siempre es clara, en cuanto las previsiones legales y reglamentarias chocan con ciertas limitaciones de la normativa administrativa general aplicable: así ocurre singularmente con el principio registral de legitimación en relación con aquellos mecanismos de control en vía administrativa cuya puesta en marcha corresponde de oficio a la propia Administración Pública./The configuration of the Registries of Cooperatives as administrative instruments withlegal effect, raises a series of difficulties of doubtless practical importance. Out of them, wecan underline one: the control behind the registration activity.In this sense, the multiplying number of norms that shape current legal cooperativescene, may involve many divergent resolutions that, on top of the issues caused behind apotential excess of competence, may also has consequences on both the legal security as wellas on the nature and reach of the judicial control.On the other hand, the hybrid character of the Registries of Cooperatives may needsome adjustments whose solution is not always clear, due to the legal and legitimateassessments mismatching some restrictions of the applicable general administrative norm.This can be illustrated behind the registry principle of legitimacy, related to

  10. Co-operation and Competition in Regional Economic Development Associated with Radioactive Waste Management

    Competition and co-operation appear in many different social venues. The author gives a variety of examples of co-operative behaviour in economics, politics, research, and everyday life activities such as sports. These four diverse examples illustrate the variety of forms that co-operation may take such as tacit co-operation, incremental co-operation, deep co-operation, etc. The links with the form of democracy (adversary democracy or consensual democracy) are also pointed. However, as with so many other things in life, the key is to the question of co-operation or competition is balance. Co-operation and competition are dialectical opposites. They create and maintain and define each other; they each are incomplete without the other

  11. Better Together: Outcomes of Cooperation Versus Competition in Social Exergaming

    Marker, Arwen M.

    2015-01-01

    Abstract Children and adolescents most often play active videogames, or exergames, in a social environment. Social play may enhance the potential benefits of an exergaming experience, much like group exercise and team sports are observed to improve physical activity–related outcomes above those of solitary exercise. Two ubiquitous elements of exergames are cooperation and competition. Previous literature suggests that cooperative and competitive aspects of exergames may affect physiological and psychosocial changes. Competitive play has been found to increase energy expenditure and aggression in short bouts of exergaming. Cooperative exergaming has been found to increase motivation, promote continued play, enhance self-efficacy, and increase pro-social behaviors. In one study, a cooperative exergaming condition also resulted in significant weight loss for overweight and obese adolescents. Individual player differences such as individual preferences, competitiveness, weight status, age, gender, and ethnicity may moderate effects. Although the current volume of literature on competition and cooperation in exergaming is small, social exergames hold promise as an engaging alternative to traditional physical activity interventions and may promote a broad range of positive outcomes for children and adolescents. Principles of cooperation and competition are applicable for developers of health-promoting games. Future research is needed to further understand the mechanisms of how competition and cooperation in social exergaming impact physiological and psychosocial outcomes. PMID:26181677

  12. Structure/function analysis of the Pantoea stewartii quorum-sensing regulator EsaR as an activator of transcription.

    Schu, Daniel J; Carlier, Aurelien L; Jamison, Katherine P; von Bodman, Susanne; Stevens, Ann M

    2009-12-01

    In Pantoea stewartii subsp. stewartii, two regulatory proteins are key to the process of cell-cell communication known as quorum sensing: the LuxI and LuxR homologues EsaI and EsaR. Most LuxR homologues function as activators of transcription in the presence of their cognate acylated homoserine lactone (AHL) signal. However, EsaR was initially found to function as a repressor in the absence of AHL. Previous studies demonstrated that, in the absence of AHL, EsaR retains the ability to function as a weak activator of the lux operon in recombinant Escherichia coli. Here it is shown that both the N-terminal and the C-terminal domains of EsaR are necessary for positive regulation. A site-directed mutagenesis study, guided by homology modeling to LuxR and TraR, has revealed three critical residues in EsaR that are involved in activation of RNA polymerase. In addition, a native EsaR-activated promoter has been identified, which controls expression of a putative regulatory sRNA in P. stewartii. PMID:19820098

  13. M&A Cooperative Games

    Maria A. Nastych

    2014-01-01

    Cooperative game theory instruments application to the corporate finance M&A research issues provide an ability to extend the field considered and conclusions obtained. The paper presents the M&A cooperative games modeling and its empiri-cal implementation to analyze the airline strategic alliance as M&A deal.

  14. Cooperative processes in image segmentation

    Davis, L. S.

    1982-01-01

    Research into the role of cooperative, or relaxation, processes in image segmentation is surveyed. Cooperative processes can be employed at several levels of the segmentation process as a preprocessing enhancement step, during supervised or unsupervised pixel classification and, finally, for the interpretation of image segments based on segment properties and relations.

  15. Property Rights for Fishing Cooperatives

    Aburto-Oropeza, Octavio; Leslie, Heather M.; Mack-Crane, Austen; Nagavarapu, Sriniketh; Reddy, Sheila M. W.; Sievanen, Leila

    2016-01-01

    Devolving property rights to local institutions has emerged as a compelling management strategy for natural resource management in developing countries. The use of property rights among fishing cooperatives operating in Mexico's Gulf of California provides a compelling setting for theoretical and empirical analysis. A dynamic theoretical model demonstrates how fishing cooperatives' managem...

  16. Cooperative answers in database systems

    Gaasterland, Terry; Godfrey, Parke; Minker, Jack; Novik, Lev

    1993-01-01

    A major concern of researchers who seek to improve human-computer communication involves how to move beyond literal interpretations of queries to a level of responsiveness that takes the user's misconceptions, expectations, desires, and interests into consideration. At Maryland, we are investigating how to better meet a user's needs within the framework of the cooperative answering system of Gal and Minker. We have been exploring how to use semantic information about the database to formulate coherent and informative answers. The work has two main thrusts: (1) the construction of a logic formula which embodies the content of a cooperative answer; and (2) the presentation of the logic formula to the user in a natural language form. The information that is available in a deductive database system for building cooperative answers includes integrity constraints, user constraints, the search tree for answers to the query, and false presuppositions that are present in the query. The basic cooperative answering theory of Gal and Minker forms the foundation of a cooperative answering system that integrates the new construction and presentation methods. This paper provides an overview of the cooperative answering strategies used in the CARMIN cooperative answering system, an ongoing research effort at Maryland. Section 2 gives some useful background definitions. Section 3 describes techniques for collecting cooperative logical formulae. Section 4 discusses which natural language generation techniques are useful for presenting the logic formula in natural language text. Section 5 presents a diagram of the system.

  17. Generation Z, Meet Cooperative Learning

    Igel, Charles; Urquhart, Vicki

    2012-01-01

    Today's Generation Z teens need to develop teamwork and social learning skills to be successful in the 21st century workplace. Teachers can help students develop these skills and enhance academic achievement by implementing cooperative learning strategies. Three key principles for successful cooperative learning are discussed. (Contains 1 figure.)

  18. Cooperative Education in Outdoor Education

    Martin, Andy; Flemming, Jenny

    2010-01-01

    Cooperative education is a structured experiential education strategy integrating classroom studies with work place learning. The purpose of this paper is to evaluate how a cooperative education model can be included within an outdoor education undergraduate degree to develop reflective practitioners and to enhance graduate capabilities. Document…

  19. Does facial resemblance enhance cooperation?

    Trang Giang

    Full Text Available Facial self-resemblance has been proposed to serve as a kinship cue that facilitates cooperation between kin. In the present study, facial resemblance was manipulated by morphing stimulus faces with the participants' own faces or control faces (resulting in self-resemblant or other-resemblant composite faces. A norming study showed that the perceived degree of kinship was higher for the participants and the self-resemblant composite faces than for actual first-degree relatives. Effects of facial self-resemblance on trust and cooperation were tested in a paradigm that has proven to be sensitive to facial trustworthiness, facial likability, and facial expression. First, participants played a cooperation game in which the composite faces were shown. Then, likability ratings were assessed. In a source memory test, participants were required to identify old and new faces, and were asked to remember whether the faces belonged to cooperators or cheaters in the cooperation game. Old-new recognition was enhanced for self-resemblant faces in comparison to other-resemblant faces. However, facial self-resemblance had no effects on the degree of cooperation in the cooperation game, on the emotional evaluation of the faces as reflected in the likability judgments, and on the expectation that a face belonged to a cooperator rather than to a cheater. Therefore, the present results are clearly inconsistent with the assumption of an evolved kin recognition module built into the human face recognition system.

  20. Subsidizing R&D cooperatives

    J. Hinloopen

    2001-01-01

    A framework is developed with which the implementation of two commonly used R&D-stimulating policies can be evaluated: providing R&D subsidies and sustaining the formation of R&D cooperatives. Subsidized R&D cooperatives can also be analyzed. The analysis shows that providing R&D subsidies is more e

  1. Cooperation between CERN and ITER

    CERN Audiovisual Service

    2008-01-01

    CERN and the International Fusion Organisation ITER have just signed a first cooperation agreeement. The Director-General of the International Fusion Energy Organization, Mr Kaname Ikeda, and CERN Director-General, Robert Aymar, signed a cooperation agreement at a meeting on the Meyrin site on Thursday 6 March.

  2. Teaching Cooperative Skills through Games.

    Glakas, Barbara A.

    1991-01-01

    Through cooperative games and play, children learn to share, empathize with others' feelings, and get along better. The article makes suggestions to physical educators on how to design games to teach students cooperative behaviors and how to incorporate them into class, noting four important game-design principles. (SM)

  3. Progress of international evaluation cooperation

    Shibata, Keiichi [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment

    1998-03-01

    The international evaluation cooperation started to remove the differences among major nuclear data libraries such as JENDL, ENDF, and JEF. The results obtained from the cooperation have been used to improve the quality of the libraries. This paper describes the status of the ongoing projects and several remarkable results so far obtained from the projects already finished. (author)

  4. Cooperative Learning for Better Performance.

    Di Natale, John J.; Russell, Gordon

    1995-01-01

    Asserts that linking music ensemble programs and cooperative learning strategies often has been overlooked. Describes the benefits of cooperative learning techniques for music performance preparation. Concludes that the small-group approach can enhance traditional music programs by offering students the chance to make their own decisions. (CFR)

  5. Transparency in Cooperative Online Education

    Dalsgaard, Christian; Paulsen, Morten Flate

    2009-01-01

    feature of social networking services. Transparency gives students insight into each other’s actions. Cooperative learning seeks to develop virtual learning environments that allow students to have optimal individual freedom within online learning communities. This article demonstrates how cooperative...... learning can be supported by transparency. To illustrate this with current examples, the article presents NKI Distance Education’s surveys and experiences with cooperative learning. The article discusses by which means social networking and transparency may be utilized within cooperative online education......The purpose of this article is to discuss the following question: What is the potential of social networking within cooperative online education? Social networking does not necessarily involve communication, dialogue, or collaboration. Instead, the authors argue that transparency is a unique...

  6. Non-cooperative game theory

    Fujiwara-Greve, Takako

    2015-01-01

    This is a textbook for university juniors, seniors, and graduate students majoring in economics, applied mathematics, and related fields. Each chapter is structured so that a core concept of that chapter is presented with motivations, useful applications are given, and related advanced topics are discussed for future study. Many helpful exercises at various levels are provided at the end of each chapter. Therefore, this book is most suitable for readers who intend to study non-cooperative game theory rigorously for both theoretical studies and applications. Game theory consists of non-cooperative games and cooperative games. This book covers only non-cooperative games, which are major tools used in current economics and related areas. Non-cooperative game theory aims to provide a mathematical prediction of strategic choices by decision makers (players) in situations of conflicting interest. Through the logical analyses of strategic choices, we obtain a better understanding of social (economic, business) probl...

  7. The Dose Makes The Cooperation

    Cetin, Uzay

    2016-01-01

    Explaining cooperation is one of the greatest challenges for basic scientific research. We proposed an agent-based model to study co-evolution of memory and cooperation. In our model, reciprocal agents with limited memory size play Prisoner's Dilemma Game iteratively. The characteristic of the environment, whether it is threatening or not, is embedded in the payoff matrix. Our findings are as follows. (i) Memory plays a critical role in the protection of cooperation. (ii) In the absence of threat, subsequent generations loose their memory and are consequently invaded by defectors. (iii) In contrast, the presence of an appropriate level of threat triggers the emergence of a self-protection mechanism for cooperation within subsequent generations. On the evolutionary level, memory size acts like an immune response of the population against aggressive defection. (iv) Even more extreme threat results again in defection. Our findings boil down to the following: The dose of the threat makes the cooperation.

  8. Social Cooperative – an Important Entity of the Social Economy

    Florina Oana Virlanuta

    2014-11-01

    Full Text Available Contemporary society is characterized by a number of social problems that have multiple causes that range from structural weaknesses of purely individual factors. In the challenges of globalization phenomenon and in the context of sustainable development needs of humanity, the cooperative movement has an important role. Cooperative organizations have the ability to provide viable alternatives, being the main actors of social economy, along with associations and foundations, putting the human in the center of the activity and bringing another report in the process of creating economic value. Also, the cooperative movement is a solution for the multiple and the difficult economic and social issues of the contemporary world.

  9. Loss of cooperativity of secreted CD40L and increased dose-response to IL4 on CLL cell viability correlates with enhanced activation of NF-kB and STAT6.

    Bhattacharya, Nupur; Reichenzeller, Michaela; Caudron-Herger, Maiwen; Haebe, Sarah; Brady, Nathan; Diener, Susanne; Nothing, Maria; Döhner, Hartmut; Stilgenbauer, Stephan; Rippe, Karsten; Mertens, Daniel

    2015-01-01

    Chronic lymphocytic leukemia (CLL) cells fail to enter apoptosis in vivo as opposed to their non-malignant B-lymphocyte counterparts. The ability of CLL cells to escape apoptosis is highly dependent on their microenvironment. Compared to non-malignant B cells, CLL cells are more responsive to complex stimuli that can be reproduced in vitro by the addition of cytokines. To understand the molecular mechanism of the environment-dependent anti-apoptotic signaling circuitry of CLL cells, we quantified the effect of the SDF-1, BAFF, APRIL, anti-IgM, interleukin-4 (IL4) and secreted CD40L (sCD40L) on the survival of in vitro cultured CLL cells and found IL4 and sCD40L to be most efficient in rescuing CLL cells from apoptosis. In quantitative dose-response experiments using cell survival as readout, the binding affinity of IL4 to its receptor was similar between malignant and non-malignant cells. However, the downstream signaling in terms of the amount of STAT6 and its degree of phosphorylation was highly stimulated in CLL cells. In contrast, the response to sCD40L showed a loss of cooperative binding in CLL cells but displayed a largely increased ligand binding affinity. Although a high-throughput microscopy analysis did not reveal a significant difference in the spatial CD40 receptor organization, the downstream signaling showed an enhanced activation of the NF-kB pathway in the malignant cells. Thus, we propose that the anti-apoptotic phenotype of CLL involves a sensitized response for IL4 dependent STAT6 phosphorylation, and an activation of NF-kB signaling due to an increased affinity of sCD40L to its receptor. PMID:24828787

  10. Co-operatives as heating entrepreneurs

    The objective of heating entrepreneurship functioning in the form of a co operative is to make the use of the wood chips competitive primarily through district heating of municipal centres. When compared with the conventional heating mode the reliability of chip delivery and the remuneration paid to the co-operative for attending to the running of the heating centres are considered to be the competitive advantages. The system has proven to be a working one; one indication of this is its growing application in the country. In the spring of the year 2000 there were 26 chip-based energy co-operative active in Finland. The first time that the use of bioenergy underwent a powerful rise was in the 1970s as a consequence of the oilcrises. Subsequently the enthusiasm shown to this energy form subsided. Then in the early 1990s, biofuels once again became a subject of interest mainly due to environmental issues, the restructuring of rural areas and silvicultural reasons. With the past decades' experiences forming the basis, the development needs associated with the use of bioenergy were in fresh memory and they were addressed on a wide font. Boiler technology related to solid fuels evolved rapidly and the least successful manufacturers had been eliminated by the recession. In the case of co-operative heating entrepreneurship, the commonest form neither the district heating centre nor the system of heat-transfer pipes belong to co-operative society. The co-operative is responsible only for the delivery of the fuel and for looking after the heating plant. Remuneration is generally based on the amount of energy leaving the district heating plant. Thus the heat dissipated at the heating plant is the co-operative's problem and the heat dissipated during transfer are the energy buyer's problem. The investor in the equipments usually the local municipality or an energy utility. In some cases the co-operative owns the equipments well, in which case it is correct to speak of

  11. Let's dance together: synchrony, shared intentionality and cooperation.

    Paul Reddish

    Full Text Available Previous research has shown that the matching of rhythmic behaviour between individuals (synchrony increases cooperation. Such synchrony is most noticeable in music, dance and collective rituals. As well as the matching of behaviour, such collective performances typically involve shared intentionality: performers actively collaborate to produce joint actions. Over three experiments we examined the importance of shared intentionality in promoting cooperation from group synchrony. Experiment 1 compared a condition in which group synchrony was produced through shared intentionality to conditions in which synchrony or asynchrony were created as a by-product of hearing the same or different rhythmic beats. We found that synchrony combined with shared intentionality produced the greatest level of cooperation. To examinef the importance of synchrony when shared intentionality is present, Experiment 2 compared a condition in which participants deliberately worked together to produce synchrony with a condition in which participants deliberately worked together to produce asynchrony. We found that synchrony combined with shared intentionality produced the greatest level of cooperation. Experiment 3 manipulated both the presence of synchrony and shared intentionality and found significantly greater cooperation with synchrony and shared intentionality combined. Path analysis supported a reinforcement of cooperation model according to which perceiving synchrony when there is a shared goal to produce synchrony provides immediate feedback for successful cooperation so reinforcing the group's cooperative tendencies. The reinforcement of cooperation model helps to explain the evolutionary conservation of traditional music and dance performances, and furthermore suggests that the collectivist values of such cultures may be an essential part of the mechanisms by which synchrony galvanises cooperative behaviours.

  12. Let’s Dance Together: Synchrony, Shared Intentionality and Cooperation

    Reddish, Paul; Fischer, Ronald; Bulbulia, Joseph

    2013-01-01

    Previous research has shown that the matching of rhythmic behaviour between individuals (synchrony) increases cooperation. Such synchrony is most noticeable in music, dance and collective rituals. As well as the matching of behaviour, such collective performances typically involve shared intentionality: performers actively collaborate to produce joint actions. Over three experiments we examined the importance of shared intentionality in promoting cooperation from group synchrony. Experiment 1 compared a condition in which group synchrony was produced through shared intentionality to conditions in which synchrony or asynchrony were created as a by-product of hearing the same or different rhythmic beats. We found that synchrony combined with shared intentionality produced the greatest level of cooperation. To examinef the importance of synchrony when shared intentionality is present, Experiment 2 compared a condition in which participants deliberately worked together to produce synchrony with a condition in which participants deliberately worked together to produce asynchrony. We found that synchrony combined with shared intentionality produced the greatest level of cooperation. Experiment 3 manipulated both the presence of synchrony and shared intentionality and found significantly greater cooperation with synchrony and shared intentionality combined. Path analysis supported a reinforcement of cooperation model according to which perceiving synchrony when there is a shared goal to produce synchrony provides immediate feedback for successful cooperation so reinforcing the group’s cooperative tendencies. The reinforcement of cooperation model helps to explain the evolutionary conservation of traditional music and dance performances, and furthermore suggests that the collectivist values of such cultures may be an essential part of the mechanisms by which synchrony galvanises cooperative behaviours. PMID:23951106

  13. The present status of International Nuclear Cooperation of Korea and the expectations from PNC's role

    The international cooperation activities for peaceful uses of nuclear energy in Korea started with the cooperation and assistance provided by advanced countries in the early 1960s when a feasibility study for a nuclear power reactor was carried out for its introduction into the Korean power system. Currently, we have 9 nuclear energy cooperation agreements concluded with foreign governments and also maintain cooperation relations with power companies, research institutes, A/E companies, manufacturers, etc. in 15 countries. The international cooperation activities cover a wide range of nuclear industries from design of nuclear power plant to nuclear fuel cycle, but need to expand into exchange of co-operation for noncommercial nuclear safety and cultural aspects. It is relatively simple and easy to realize international nuclear cooperation on commercial base such as nuclear reactor procurement contract, but unfavorable result can be expected from noncommercial transactions

  14. HUMAN MACHINE COOPERATIVE TELEROBOTICS

    research described as Human Machine Cooperative Telerobotics (HMCTR). The HMCTR combines the telerobot with robotic control techniques to improve the system efficiency and reliability in teleoperation mode. In this topical report, the control strategy, configuration and experimental results of Human Machines Cooperative Telerobotics (HMCTR), which modifies and limits the commands of human operator to follow the predefined constraints in the teleoperation mode, is described. The current implementation is a laboratory-scale system that will be incorporated into an engineering-scale system at the Oak Ridge National Laboratory in the future

  15. HUMAN MACHINE COOPERATIVE TELEROBOTICS

    William R. Hamel; Spivey Douglass; Sewoong Kim; Pamela Murray; Yang Shou; Sriram Sridharan; Ge Zhang; Scott Thayer; Rajiv V. Dubey

    2003-06-30

    described as Human Machine Cooperative Telerobotics (HMCTR). The HMCTR combines the telerobot with robotic control techniques to improve the system efficiency and reliability in teleoperation mode. In this topical report, the control strategy, configuration and experimental results of Human Machines Cooperative Telerobotics (HMCTR), which modifies and limits the commands of human operator to follow the predefined constraints in the teleoperation mode, is described. The current implementation is a laboratory-scale system that will be incorporated into an engineering-scale system at the Oak Ridge National Laboratory in the future.

  16. Intercommunal cooperation for the purpose of satisfying local power demand

    The article deals with the following: communal competences in the area of the power economy; forms of communal activity in the area of power supply; specific forms of communal cooperation; the procedure of communal cooperation; legal personality and internal organization; the local administration union as an instrument of power supply; categorization of the local administration union with respect to the legal system; the communal administrative agreement. (HSCH)

  17. Promoting corporate social responsibility in logistics throughout horizontal cooperation:

    Raúl León; Juan, Angel A.

    2014-01-01

    This paper discusses how Corporate Social Responsibility (CSR) can be promoted in Logistics and Transportation (L&T) companies by means of Horizontal Cooperation (HC) practices. The L&T sector is experiencing important changes because of new trends in markets and society. These changes have a strong impact on the way L&T companies develop their distribution activities. On the one hand, globalisation and increasing competition are creating incentives for these companies to cooperate in differe...

  18. Promoting Corporate Social Responsibility in Logistics throughout Horizontal Cooperation

    Angel A. Juan

    2014-01-01

    This paper discusses how Corporate Social Responsibility (CSR) can be promoted in Logistics and Transportation (L&T) companies by means of Horizontal Cooperation (HC) practices. The L&T sector is experiencing important changes because of new trends in markets and society. These changes have a strong impact on the way L&T companies develop their distribution activities.On the one hand, globalisation and increasing competition are creating incentives for these companies to cooperate in differen...

  19. Cooperatives in the northern Amazon paths and detours

    Pereira, Meire Joisy Almeida; Santos, Antonio Ronildo Viana

    2013-01-01

    This paper aims to reveal the institutional context of the cooperative movement in the micro southeast of Roraima. The region is distinguished by the production of banana (Musa spp), Caroebe being considered the largest municipality of the state's production. The fact confirms the city being chosen as the starting point for construction and institutionalization of the cooperative movement in the southern state. Production organization was guided by the activity in the traditional way, without...

  20. Dividend and Profit Allocation Practices of Performing Cooperatives in Malaysia

    Rafedah Juhan; Farahaini Mohd. Hanif; Mohd. Shahron Anuar Said; Sushila Devi Rajaratnam; Nurizah Noordin

    2012-01-01

    This paper explores the dividend payout and profit allocation practices of performing cooperatives in Malaysia, specifically how net profits were distributed as between dividends and various funds established for the benefit of members, after the necessary statutory deduction has been made. This paper is an exploratory study that is confined to performing co-operatives throughout Malaysia of different sizes and activities. Figures were derived from the 2008, 2007 and 2006 audited annual finan...

  1. Better Together: Outcomes of Cooperation Versus Competition in Social Exergaming

    Marker, Arwen M.; Staiano, Amanda E.

    2015-01-01

    Children and adolescents most often play active videogames, or exergames, in a social environment. Social play may enhance the potential benefits of an exergaming experience, much like group exercise and team sports are observed to improve physical activity–related outcomes above those of solitary exercise. Two ubiquitous elements of exergames are cooperation and competition. Previous literature suggests that cooperative and competitive aspects of exergames may affect physiological and psycho...

  2. Strategic Renewal, Cooperation, and Performance:A Contingency Approach

    2011-01-01

    In this paper, we analyse the influence of cooperation and strategic renewal activities on firm performance. Previous studies on the relationship between strategic renewal and performance are inconclusive. Thus, to cope with this controversy, we follow a contingency approach and, using a large sample of firms, investigate how cooperation and the degree of technological intensity of the environment moderate the relationship between strategic renewal and performance. The results of our empirica...

  3. Research on Sensor Cooperation for Distributed Emergency Response System

    Haoming Guo; Feng Liang; Yunzhen Liu

    2012-01-01

    With advantages of IOT (internet of things) and sensor technique, a new communication mechanism between sensors is enhanced upon which distributed emergency response systems are built. This mechanism enables sensors to cooperate with each other in a decentralized way to improve efficiency in case of emergencies. During the process, the alert messages are exchanged among sensors cooperatively to prepare and implement monitoring activities. The system center won’t be overloaded by floodin...

  4. Future direction for implementing the multilateral cooperation with the IAEA

    Korea has achieved remarkable results in the development of nuclear technology over the past years. Nuclear R and D programs have been actively pursued with the aim of enhancing nuclear technological capability to the level of nuclear advanced countries by early 2000. Worth noting is the fact that the IAEA has played an important role in facilitating Korea's acquisition of advanced nuclear technologies by participating in IAEA technical cooperation programmes, and technical cooperation with the IAEA has laid a firm groundwork for Korea to achieve self-reliance in nuclear technology. Technical cooperation with the IAEA should be steadily pursued so that Korea can play a leading role in the international nuclear arena in the years to come. Up to now, the study of major programmes and of the current status of overall technical cooperation projects, which have been implemented by the IAEA, has been insufficient. It should be noted that analysis of the assistance provided by the IAEA leaves something to be desired. In this regard, analyzing the current status of technical cooperation projects as well as recommending policy direction is required in a bid to implement IAEA technical cooperation projects systematically. Korea's status within the IAEA, including activities in the Advisory Committee and the current status of its participation in Coordinated Research Programmes (CRP) and other major programmes underway, is presented in this report. The policy direction for and implementation status of IAEA technical cooperation programmes are explained at length. The current status of technical cooperation programmes carried out in the 1997-1998 cycle and those to be implemented in the 1992-2000 cycle are also described in this report. Strategies for upgrading Korea's status within the IAEA as well as directions for nuclear cooperation through the IAEA were presented in this study to positively deal with rapid changes in the international nuclear arena and to efficiently

  5. Future direction for implementing the multilateral cooperation with the IAEA

    Kim, Kyoung Pyo; Hong, Young Don

    1999-03-01

    Korea has achieved remarkable results in the development of nuclear technology over the past years. Nuclear R and D programs have been actively pursued with the aim of enhancing nuclear technological capability to the level of nuclear advanced countries by early 2000. Worth noting is the fact that the IAEA has played an important role in facilitating Korea's acquisition of advanced nuclear technologies by participating in IAEA technical cooperation programmes, and technical cooperation with the IAEA has laid a firm groundwork for Korea to achieve self-reliance in nuclear technology. Technical cooperation with the IAEA should be steadily pursued so that Korea can play a leading role in the international nuclear arena in the years to come. Up to now, the study of major programmes and of the current status of overall technical cooperation projects, which have been implemented by the IAEA, has been insufficient. It should be noted that analysis of the assistance provided by the IAEA leaves something to be desired. In this regard, analyzing the current status of technical cooperation projects as well as recommending policy direction is required in a bid to implement IAEA technical cooperation projects systematically. Korea's status within the IAEA, including activities in the Advisory Committee and the current status of its participation in Coordinated Research Programmes (CRP) and other major programmes underway, is presented in this report. The policy direction for and implementation status of IAEA technical cooperation programmes are explained at length. The current status of technical cooperation programmes carried out in the 1997-1998 cycle and those to be implemented in the 1992-2000 cycle are also described in this report. Strategies for upgrading Korea's status within the IAEA as well as directions for nuclear cooperation through the IAEA were presented in this study to positively deal with rapid changes in the international nuclear arena and to

  6. 29 CFR 1607.8 - Cooperative studies.

    2010-07-01

    ... EMPLOYEE SELECTION PROCEDURES (1978) General Principles § 1607.8 Cooperative studies. A. Encouragement of cooperative studies. The agencies issuing these guidelines encourage employers, labor organizations, and employment agencies to cooperate in research, development, search for lawful alternatives, and...

  7. Social Capital and Diversification of Cooperatives

    W. Deng (Wendong)

    2015-01-01

    markdownabstract__Abstract__ This thesis contributes to two research streams of the literature regarding agricultural cooperatives, namely, social capital and product diversification of cooperatives. First, the thesis examines the nature of a marketing cooperative by considering both its economic a

  8. Creativity in a cooperative group setting

    Foster, Gerald W.; Penick, John E.

    This study was to determine whether cooperative small groups would stimulate creativity of fith and sixth grade students more than an individualized learning environment. Student aptitudes for creative and academic work were assessed on the Torrance Tests of Creative Thinking (Verbal Form A), analysis of student created electrical circuit diagrams, and a batteries and bulbs prediction test. A measure of student perceptions was also used to indicate any changes in attitudes toward the science activity and learning environment. A posttest control group design was used with 11 I fifth and sixth grade students. Half of the population worked by themselves, while the other half (experimental) worked in a student-structured environment on the same science activity which involved creating as many different types of electrical circuits from a given set of batteries and bulbs as possible. An overall conclusion is that fifth and sixth grade students working within small cooperative groups can be more creative as measured by a figural creativity test with electrical circuits than students working alone. The implication of this study is that small cooperative groups as well as individualized groups should be used in elementary science classes when creativity is one of the instructional objectives.

  9. Study on the Cooperative E-commerce Model between Enterprises based on the Value Chain

    XU Jun[1,2; LIU Xiaoxing[1

    2015-01-01

    The real e-commerce between enterprises is based on the internal departments of enterprises and the cooperative interaction between enterprise and its partners. In this paper, on the basis of the theory of value chain, 11 cooperative e-commerce models between enterprises have been classified according to the activities of the cooperation between enterprises, and then every cooperative e-commerce model between enterprises is discussed. In practice, cooperative e-commerce between enterprises can be a combination of one or more e-commerce models between enterprises.

  10. The Research on Social Capital of Industry-University-Research Institute Cooperation

    Lin Bao

    2009-02-01

    Full Text Available The technological cooperation and technological innovation are not only the material and technological activities, but also the complex social process. The industry-university-research institute (IUR cooperation cannot success without the social capital which is embedded in the cooperative members’ relation network. Based on the framework of social capital Nahapiet and Ghoshal concluded, this article analyzed the social capital factors which influence realization of industry-university-research institute cooperation from the structural, relational and cognitive dimensions. And it proposed some countermeasures to promote realization of IUR cooperation in the perspective of social capital.

  11. International cooperation in cold forging technology

    Bay, Niels; Lange, K

    International cooperation in the field of cold forging technology started in 1961 by formation of the OECD Group of Experts on Metal Forming. In 1967 this group was transformed into the International Cold Forging Group, ICFG, an independent body which has now been operative for 25 years. Members of...... the ICFG are personally elected by the Plenary as experts within the field, often representing national groups within cold forging. The main work within the ICFG is carried out in its subgroups which are established by the Plenary to collect, compile and evaluate data and eventually also produce data...... by cooperative activities or by instigating national research. These subgroups have produced 9 data sheets and 7 guidelines on subjects such as materials, tool design and construction, calculation methods for cold forging tools, manufacture of slugs, lubrication aspects and small quantity production...

  12. Cooperative Testing of Uncontrollable Timed Systems

    David, Alexandre; Larsen, Kim Guldstrand; Li, Shuhao;

    2008-01-01

    Timed CTL formula. We can employ a timed game solver UPPAAL-TIGA to check if the test purpose is ture w.r.t. the model, and if yes, to generate a winning strategy and use it for black-box conformance testing. Specifically, we show that in case the checking yields a negative result, we can still test the...... SUT against the test purpose as long as the SUT reacts to our moves in a cooperative style. We present an operational framework of cooperative winning strategy generation, test case derivation and execution. The test method is proved to be sound and complete. Preliminary experimental results indicate......Abstract. This paper deals with targeted testing of timed systems with uncontrollable behavior. The testing activity is viewed as a game between the tester and the system under test (SUT) towards a given test purpose. The SUT is modeled as Timed Game Automaton and the test purpose is specified in...

  13. Toward a Cooperative Experimental System Development Approach

    Grønbæk, Kaj; Kyng, Morten; Mogensen, Preben Holst

    1997-01-01

    This chapter represents a step towards the establishment of a new system development approach, called Cooperative Experimental System Development (CESD). CESD seeks to overcome a number of limitations in existing approaches: specification oriented methods usually assume that system design can be...... realisation from concrete activities and techniques. Thus we introduce a CESD model which provides a framework for handling this separation and at the same time makes it possible to identify and discuss the rich variety of relationships among concrete activities and the main concerns....

  14. The Social Maintenance of Cooperation through Hypocrisy

    Bodnar, Todd; Salathé, Marcel

    2013-01-01

    Cooperation is widespread in human societies, but its maintenance at the group level remains puzzling if individuals benefit from not cooperating. Explanations of the maintenance of cooperation generally assume that cooperative and non-cooperative behavior in others can be assessed and copied accurately. However, humans have a well known capacity to deceive and thus to manipulate how others assess their behavior. Here, we show that hypocrisy - claiming to be acting cooperatively while acting ...

  15. Are Cooperatives Efficient When Membership is Voluntary?

    Leathers, Howard D.

    2006-01-01

    If profit-maximizing farmers are free to join or not to join a cooperative, it may appear reasonable to assume that a cooperative will exist only when it has cost advantaged over non-cooperative marketing. This paper presents a model in which that result fails. Every individual farmer chooses either to join or not join a cooperative depending on whether transactions costs are lower from cooperative membership or nonmembership. As cooperative membership increases, transactions costs for member...

  16. Value solutions in cooperative games

    McCain, Roger A

    2013-01-01

    This book introduces new concepts for cooperative game theory, and particularly solutions that determine the distribution of a coalitional surplus among the members of the coalition. It also addresses several generalizations of cooperative game theory. Drawing on methods of welfare economics, new value solutions are derived for Non-Transferable Utility games with and without differences of bargaining power among the members of the coalition. Cooperation in intertemporal games is examined, and conditions that permit the reduction of these games to games in coalition function form are outlined.

  17. IAEA technical co-operation with least developed Member States. Special evaluation

    The main purposes of this evaluation were to: Review the overall situation with regard to IAEA technical co-operation with least developed Member States, including specific conditions in nuclear-related activities prevailing in these countries, approaches and practices used by the IAEA in providing assistance to LDCs, and the main results of the co-operation in question. Identify any adjustments to technical co-operation with LDC Member States that may strengthen this activity

  18. Progress report on the regulatory cooperation program between the Norwegian Radiation Protection Authority and the Federal Medical Biological Agency of Russia. Final report of projects and other activities completed in 2008-2009 and plans for 2010-2011

    Roudak, S. F.; Sneve, M. K.; Kiselev, M.; Shandala, N. K.

    2011-06-15

    This report sets out the progress made in the projects and related activities carried out in the period 2008 - 2009 within the Regulatory Cooperation Program between the Norwegian Radiation Protection Authority and the Federal Medical Biological Agency of Russia. The progress described follows directly from previous work carried out within the Regulatory Cooperation Program, as set out in earlier NRPA reports and in accordance with the Norwegian Government's Plan of Action to improve nuclear and radiation safety in Northwest Russia. The work was carried out by specialists of the Burnasyan Federal Medical Biophysical Centre, with support from other Russian organisations and specialists as well as experts from the NRPA. Five main projects are described, each of which has contributed to the improvement of regulatory supervision by the FMBA over the sites operated by SevRAO in the Northwest of Russia, including the Sites for Temporary Storage at Andreyev Bay and Gremikha, and the Regional Centre for Waste Conditioning and Long-term Storage at Saida Bay. The main activities of interest include recovery and secure the safe condition of spent nuclear fuel and radioactive waste from inadequate storage facilities and ensuring their continued future safe storage. The topics covered by these projects include: Control of Occupational Exposure and Optimisation During Hazardous Operations through the Development of Databases on Radiation Situation and Individual Occupational Exposure (DOSEMAP). The software for a mapping database of radiation situation parameters at SevRAO Facilities has been developed. A computer scheme of workshops in new Complex facilities for the spent nuclear fuel and radioactive waste management, the design of which is already available, has been developed. The software for the database on individual doses to the SevRAO workers has also been developed. Two draft guidance documents have been prepared: 'Application of the database on the radiation

  19. Cooperative path planning and cooperative perception for UAVs swarm

    M. A. Shah

    2012-01-01

    In this research Pythagorean Hodograph based path planning and camera based cooperative perception are investigated separately and then these two entirely separate areas (Path Planning and Perception) are integrated for the application in online pop-up obstacle locating & avoidance and moving target tracking & surveillance in dynamic environments. The path planning is integrated with the cooperative perception to deal with the challenges posed by the dynamic environment. The aim of this integ...

  20. Distinct neural patterns of social cognition for cooperation versus competition.

    Tsoi, Lily; Dungan, James; Waytz, Adam; Young, Liane

    2016-08-15

    How do people consider other minds during cooperation versus competition? Some accounts predict that theory of mind (ToM) is recruited more for cooperation versus competition or competition versus cooperation, whereas other accounts predict similar recruitment across these two contexts. The present fMRI study examined activity in brain regions for ToM (bilateral temporoparietal junction, precuneus, dorsomedial prefrontal cortex) across cooperative and competitive interactions with the same individual within the same paradigm. Although univariate analyses revealed that ToM regions overall were recruited similarly across interaction contexts, multivariate pattern analyses revealed that these regions nevertheless encoded information separating cooperation from competition. Specifically, ToM regions encoded differences between cooperation and competition when people believed the outcome was determined by their and their partner's choices but not when the computer determined the outcome. We propose that, when people are motivated to consider others' mental states, ToM regions encode different aspects of mental states during cooperation versus competition. Given the role of these regions for ToM, these findings reveal distinct patterns of social cognition for distinct motivational contexts. PMID:27165762

  1. Characterization of a novel RNA polymerase mutant that alters DksA activity.

    Satory, Dominik; Halliday, Jennifer A; Sivaramakrishnan, Priya; Lua, Rhonald C; Herman, Christophe

    2013-09-01

    The auxiliary factor DksA is a global transcription regulator and, with the help of ppGpp, controls the nutritional stress response in Escherichia coli. Although the consequences of its modulation of RNA polymerase (RNAP) are becoming better explained, it is still not fully understood how the two proteins interact. We employed a series of genetic suppressor selections to find residues in RNAP that alter its sensitivity to DksA. Our approach allowed us to identify and genetically characterize in vivo three single amino acid substitutions: β' E677G, β V146F, and β G534D. We demonstrate that the mutation β' E677G affects the activity of both DksA and its homolog, TraR, but does not affect the action of other secondary interactors, such as GreA or GreB. Our mutants provide insight into how different auxiliary transcription factors interact with RNAP and contribute to our understanding of how different stages of transcription are regulated through the secondary channel of RNAP in vivo. PMID:23852871

  2. [Aware and cooperative reduction].

    Tambone, V; Ghilardi, G

    2012-01-01

    The aim of this work is to address the question of reduction in the scientific method, to evaluate its legitimacy as well as its pro and contra from an epistemological point of view. In the first paragraph we classify some kinds of reductionism, analysing their presuppositions and epistemological status and showing some examples of scientific reduction. The presentation includes a classificatory table that shows some of the different forms of biological reductionism. In the second paragraph we study the epistemology of science starting from its modern beginning: the Vienna Circle, focusing on the meaning of methodological reductionism. What did it mean for science to define itself mainly as method, which effects did this new concept of science have on methodology and what kind of problems did this movement bring about. In the third paragraph we examine the reactions triggered by methodological reductionism, we analyze the theoretical consistency of these answers, trying to offer a balanced view. We show how complexity can be seen as a paradigm of the anti-reductionism effort, and we study its epistemological basis. In the fourth paragraph we outline our operative proposal: the reduction that is both aware and cooperative. We point out the main reasons why science cannot avoid being reductive in some way, and therefore how we need to deal with this feature in order to prevent it to degenerate into reductionism. We show some examples of this new proposal taken from the practical realm and from literature, where it is possible to discern the spirit of this alternative methodology. PMID:22964706

  3. Regional Renewable Energy Cooperatives

    Hazendonk, P.; Brown, M. B.; Byrne, J. M.; Harrison, T.; Mueller, R.; Peacock, K.; Usher, J.; Yalamova, R.; Kroebel, R.; Larsen, J.; McNaughton, R.

    2014-12-01

    We are building a multidisciplinary research program linking researchers in agriculture, business, earth science, engineering, humanities and social science. Our goal is to match renewable energy supply and reformed energy demands. The program will be focused on (i) understanding and modifying energy demand, (ii) design and implementation of diverse renewable energy networks. Geomatics technology will be used to map existing energy and waste flows on a neighbourhood, municipal, and regional level. Optimal sites and combinations of sites for solar and wind electrical generation (ridges, rooftops, valley walls) will be identified. Geomatics based site and grid analyses will identify best locations for energy production based on efficient production and connectivity to regional grids and transportation. Design of networks for utilization of waste streams of heat, water, animal and human waste for energy production will be investigated. Agriculture, cities and industry produce many waste streams that are not well utilized. Therefore, establishing a renewable energy resource mapping and planning program for electrical generation, waste heat and energy recovery, biomass collection, and biochar, biodiesel and syngas production is critical to regional energy optimization. Electrical storage and demand management are two priorities that will be investigated. Regional scale cooperatives may use electric vehicle batteries and innovations such as pump storage and concentrated solar molten salt heat storage for steam turbine electrical generation. Energy demand management is poorly explored in Canada and elsewhere - our homes and businesses operate on an unrestricted demand. Simple monitoring and energy demand-ranking software can easily reduce peaks demands and move lower ranked uses to non-peak periods, thereby reducing the grid size needed to meet peak demands. Peak demand strains the current energy grid capacity and often requires demand balancing projects and

  4. Turnbull - Cooperative Palouse Prairie Restoration

    US Fish and Wildlife Service, Department of the Interior — A new Cooperative Weed Management Area (CWMA) was formed to tackle invasive plant issues within the region surrounding the refuge. This CWMA provides an opportunity...

  5. Plainview Milk Cooperative Ingredient Recall

    U.S. Department of Health & Human Services — This list includes products subject to recall in the United States since June 2009 related to products manufactured by Plainview Milk Products Cooperative.

  6. Planning and Implementing Cooperative Education.

    Brown, Sylvia J.

    1978-01-01

    Implementing cooperative education requires careful planning, institutional support, and competent staffing. Suggestions for planning, setting objectives, recruiting students, job development, student counseling and placement, liaison with other colleges offices, and institutionalization are described. (Author/LBH)

  7. Cooperative quasi-Cherenkov radiation

    Anishchenko, S V

    2014-01-01

    We study the features of cooperative parametric (quasi-Cherenkov) radiation arising when initially unmodulated electron (positron) bunches pass through a crystal (natural or artificial) under the conditions of dynamical diffraction of electromagnetic waves in the presence of shot noise. A detailed numerical analysis is given for cooperative THz radiation in artificial crystals. The radiation intensity above 200~MW$/$cm$^2$ is obtained in simulations. In two- and three-wave diffraction cases, the peak intensity of cooperative radiation emitted at small and large angles to particle velocity is investigated as a function of the particle number in an electron bunch. The peak radiation intensity appeared to increase monotonically until saturation is achieved. At saturation, the shot noise causes strong fluctuations in the intensity of cooperative parametric radiation. It is shown that the duration of radiation pulses can be much longer than the particle flight time through the crystal. This enables a thorough expe...

  8. CHINA Continuing cooperation with CERN

    During a visit to China in July, CERN Director General Carlo Rubbia signed an agreement with the Chinese Academy of Sciences which provides a reciprocal framework for CERN and China to continue and develop their scientific and technical cooperation

  9. Upper Kenai River Cooperative Plan

    US Fish and Wildlife Service, Department of the Interior — The Upper Kenai River Cooperative Plan is the product of a joint effort of the Chugach National Forest, Kenai National Wildlife Refuge, Alaska Division of Parks and...

  10. Cooperative strings and glassy interfaces.

    Salez, Thomas; Salez, Justin; Dalnoki-Veress, Kari; Raphaël, Elie; Forrest, James A

    2015-07-01

    We introduce a minimal theory of glass formation based on the ideas of molecular crowding and resultant string-like cooperative rearrangement, and address the effects of free interfaces. In the bulk case, we obtain a scaling expression for the number of particles taking part in cooperative strings, and we recover the Adam-Gibbs description of glassy dynamics. Then, by including thermal dilatation, the Vogel-Fulcher-Tammann relation is derived. Moreover, the random and string-like characters of the cooperative rearrangement allow us to predict a temperature-dependent expression for the cooperative length ξ of bulk relaxation. Finally, we explore the influence of sample boundaries when the system size becomes comparable to ξ. The theory is in agreement with measurements of the glass-transition temperature of thin polymer films, and allows quantification of the temperature-dependent thickness hm of the interfacial mobile layer. PMID:26100908

  11. COOPERATION BETWEEN TEACHER AND PATIENTS

    Egidija NOVLJAN

    1998-04-01

    Full Text Available The cooperation between the teacher and parents is very sensitive and significant field in context of promotion the development of the disabled children.With that in this article are elaborate many questions connected with successful communication between the teacher and parents. In the some time we have been engrossed in factors which made obstruct in communication, the tasks and the large register of the forms of cooperation in which are build in the huge experience come by former practice.

  12. Nanoampere pumping of Cooper pairs

    Vartiainen, Juha J.; Möttönen, Mikko; Pekola, Jukka P.; Kemppinen, Antti

    2007-01-01

    The authors have employed a tunable Cooper-pair transistor, the sluice, with radio frequency control to pump current over a resistive circuit. They find that the charge transferred per pumping cycle can be controlled with the resolution of a single Cooper pair up to hundreds of pairs. The achieved nanoampere current features more than an order of magnitude improvement over the previously reported results and it is close to the theoretical maximum value for the measured sample.

  13. Nanoampere pumping of Cooper pairs

    Vartiainen, Juha J.; Mottonen, Mikko; Pekola, Jukka; Kemppinen, Antti

    2006-01-01

    We have employed a tunable Cooper-pair transistor, the sluice, with radio frequency control to pump current over a resistive circuit. We find that the charge transferred per pumping cycle can be controlled with the resolution of a single Cooper-pair up to hundreds of pairs. The achieved nanoampere current features more than an order of magnitude improvement over the previously reported results and it is close to the theoretical maximum value for the measured sample.

  14. COOPERATION BETWEEN TEACHER AND PATIENTS

    Egidija NOVLJAN

    1998-01-01

    The cooperation between the teacher and parents is very sensitive and significant field in context of promotion the development of the disabled children.With that in this article are elaborate many questions connected with successful communication between the teacher and parents. In the some time we have been engrossed in factors which made obstruct in communication, the tasks and the large register of the forms of cooperation in which are build in the huge experience come by former practice.

  15. Cooperative Question Answering Semantic Web

    Melo, Dora; Rodrigues, Irene Pimenta; Nogueira, Vitor

    2011-01-01

    In this paper we propose a Cooperative Question Answering System that takes as input queries expressed in natural language and is able to return a cooperative answer obtained from resources in the Semantic Web, more specifically DBpedia represented in OWL/RDF as knowledge base and WordNet to build similar questions. Our system resorts to ontologies not only for reasoning but also to find answers and is independent of prior knowledge of the semantic resources by the user. The natural language ...

  16. How cooperation became the norm

    Birch, Jonathan

    2014-01-01

    Most of the contributions to Cooperation and Its Evolution grapple with the distinctive challenges presented by the project of explaining human sociality. Many of these puzzles have a ‘chicken and egg’ character: our virtually unparalleled capacity for large-scale cooperation is the product of psychological, behavioural, and demographic changes in our recent evolutionary history, and these changes are linked by complex patterns of reciprocal dependence. There is much we do not yet understand ...

  17. INFORMATION SECURITY IN LOGISTICS COOPERATION

    Tomasz Małkus

    2015-03-01

    Full Text Available Cooperation of suppliers of raw materials, semi-finished products, finished products, wholesalers, retailers in the form of the supply chain, as well as outsourcing of specialized logistics service require ensuring adequate support of information. It concerns the use of appropriate computer tools. The security of information in such conditions of collaboration becomes the important problem for parties of contract. The objective of the paper is to characterize main issues relating to security of information in logistics cooperation.

  18. Expertness Measuring in Cooperative Learning

    Ahmadabadi, N.M.; Asadpour, M.; Khodaabakhsh, S.H.; Nakano, E.

    2000-01-01

    Cooperative Learning in a multi-agent system can improve the learning quality and learning speed. The improvement can be gained if each agent detects the expert agents and use their knowledge properly. In this paper, a new cooperative learning method, called Weighted Strategy Sharing (WSS) is introduced. Also some criteria are introduced to measure the expertness of agents. In WSS, based on the amount of its teammate expertness, each agent assigns a weight to their knowledge. These weights ar...

  19. MODERN PROBLEMS AND WAYS OF DEVELOPMENT OF COOPERATION

    Mishchenko Tatyana Leonidovna

    2013-01-01

    Full Text Available The article discusses the importance of cooperation on the current economic stage as one of the forms of cooperation in the arena of the market of small, medium and large businesses. The aim of this work is the study of contemporary problems of agricultural co-operation and development of effective ways of functioning of the cooperative sector, which is a sustainable development factor of socio-economic systems, contributes to the protection of the interests of its participants, increasing of competitiveness at the industry and national markets. In compliance of the objectives outlined the following objectives of its decision: - to justify the relevance of research in modern Economics; - to analyze the economic interdependence of market subjects and their effectiveness in key financial indicators; - identify the causes, constraining the effective development of the cooperative forms of management. The scientific novelty of the results of the study consists of the following: - it is proved that the basic idea of the cooperative movement is a transition from small businesses to large-scale activity, which today has a real embodiment in life; - it is proved that co-operation is a key element of sustainable development of rural areas and market institutions and is based on a solid social base of farms, individual farms; - as a result of the carried out estimation of parameters of functioning of the agrarian market subjects, proposed an alternative way of economic interaction of participants of the cooperative company. As a conclusion it should be noted that the development of the cooperative sector in economic realities increases significantly in the conditions of Russia's accession to the WTO, ensuring competitiveness of the domestic products and first of all the country's food security.

  20. International cooperation on breeder reactors

    In March 1977, as the result of discussions which began in the fall of 1976, the Rockefeller Foundation requested International Energy Associates Limited (IEAL) to undertake a study of the role of international cooperation in the development and application of the breeder reactor. While there had been considerable international exchange in the development of breeder technology, the existence of at least seven major national breeder development programs raised a prima facie issue of the adequacy of international cooperation. The final product of the study was to be the identification of options for international cooperation which merited further consideration and which might become the subject of subsequent, more detailed analysis. During the course of the study, modifications in U.S. breeder policy led to an expansion of the analysis to embrace the pros and cons of the major breeder-related policy issues, as well as the respective views of national governments on those issues. The resulting examination of views and patterns of international collaboration emphasizes what was implicit from the outset: Options for international cooperation cannot be fashioned independently of national objectives, policies and programs. Moreover, while similarity of views can stimulate cooperation, this cannot of itself provide compelling justification for cooperative undertakings. Such undertakings are influenced by an array of other national factors, including technological development, industrial infrastructure, economic strength, existing international ties, and historic experience

  1. Regional cooperation in RWM in the AO countries.

    Ya-anant, Nanthavan; Thiangtrongjit, Sutat

    2011-07-01

    Regional cooperation in radioactive waste management (RWM) in the Asian and Oceanic countries has been successfully developing for more than 20 y. At present, the Asian and Oceanic countries recognise that there are several projects under the regional cooperation, such as the Forum for Nuclear Cooperation in Asia (FNCA), the Asian Nuclear Safety Network (ANSN) and the International Atomic Energy Agency (IAEA) regional projects. The FNCA on Radiation Safety and RWM is an effective mechanism for enhancing socio-economic development through active regional partnership in the peaceful and safe utilisation of nuclear technology. The ANSN Topical Group on RWM is established for exchanging, pooling, and sharing knowledge in the field of nuclear safety. For IAEA regional cooperation on RWM, such as IAEA-regional project RAS/3/009 Strengthening Infrastructure of RWM can provide and support Asian and Oceanic countries for national work plan, fellowships and scientific visits as well as expert services. PMID:21561940

  2. The role of emotions in the maintenance of cooperative behaviors

    Zhang, Chunyan; Zhang, Jianlei; Weissing, Franz J.

    2014-04-01

    Our attention is focused on how individual emotions influence collective behaviors, which captures an aspect of reality missing from past studies: free riders may suffer some stress, which could adapt jointly with the individual stress intensity and size of the gaming group. With an evolutionary game theoretical approach, we gain the fixation probability for one mutant cooperator to invade and dominate the whole defecting population. When the stress intensity exceeds a threshold, natural selection favors cooperators replacing defectors in a finite population. We further infer that lower stress intensity is sufficient for one mutant cooperator to become fixed with an advantageous probability in a larger population. Moreover, when the gaming group is smaller than the population size, the more the return from the public goods, the lower the threshold of stress intensity required to facilitate the full dominance of cooperators. We hope our studies may show that individual sentiments or psychological activities will open up novel explanations for the puzzle of collective actions.

  3. Cooperative measures to mitigate Asia-Pacific maritime conflicts.

    Chai, Wen-Chung (Taiwan Navy)

    2003-05-01

    The economies of East Asia are predominantly export based and, therefore, place special emphasis on the security of the sea lines of communication (SLOCs). Due to economic globalization, the United States shares these concerns. Cooperative measures by the concerned parties could reduce the potential for disruption by maritime conflicts. Primary threats against the SLOCs are disputes over the resources under the seas, disputes over some small island groups, disputes between particular parties (China-Taiwan and North-South Korea), or illegal activities like smuggling, piracy, or terrorism. This paper provides an overview on these threats, issue by issue, to identify common elements and needed cooperation. Cooperation on other topics such as search and rescue, fisheries protection, and oil spill response may help support improved relations to prevent maritime conflicts. Many technologies can help support maritime cooperation, including improved communications links, tracking and emergency beacon devices, and satellite imaging. Appropriate technical and political means are suggested for each threat to the SLOCs.

  4. COOPERATION AND COORDINATION BETWEEN INTERNAL AND EXTERNAL AUDITING

    DIANA DUMITRESCU

    2016-02-01

    Full Text Available Between external and internal auditors it is necessary to be a good cooperation and coordination; both professionals have to be involved in building a good working relationship. Objectives of the external and internal auditors are different from the company point of view, but in the achievement of the specific goals, there are interactions and work cooperation. If the internal auditors work together with the external auditors the results will be an increasing of the quality and the effectiveness of the organization`s systems and activities. If the external auditors work together with the internal auditors will result a decreasing of the amount of the testing they do, and as consequences’ a reducing of the fees. Because there are many benefits of the cooperation between external and internal auditing it is important to find out how could be coordinated these two professional activities. This study has the purpose to examine the most important provisions that promote such kind of cooperation and work like necessary tools for coordination and to identify the Romanian`s internal and external auditors perceptions regarding that cooperation and coordination. The objective of the study is to identify the nature of the relationship between the internal audit function and the organizations’ external auditors regarding their interactions and their cooperation.

  5. trans activation by the full-length E2 proteins of human papillomavirus type 16 and bovine papillomavirus type 1 in vitro and in vivo: cooperation with activation domains of cellular transcription factors.

    Ushikai, M; Lace, M J; Yamakawa, Y.; Kono, M; Anson, J; Ishiji, T; Parkkinen, S; Wicker, N.; Valentine, M E; Davidson, I

    1994-01-01

    Papillomaviral E2 genes encode proteins that regulate viral transcription. While the full-length bovine papillomavirus type 1 (BPV-1) E2 peptide is a strong trans activator, the homologous full-length E2 product of human papillomavirus type 16 (HPV-16) appeared to vary in function in previous studies. Here we show that when expressed from comparable constructs, the full-length E2 products of HPV-16 and BPV-1 trans activate a simple E2- and Sp1-dependent promoter up to approximately 100-fold i...

  6. Cooperative Student Assessment Method: an Evaluation Study

    Antonella Grasso

    2006-06-01

    Full Text Available Training through the Internet poses a series of technical problems and pedagogical issues. Traditional training is not indiscriminate but takes on different forms according to the needs of the subject being trained and the context where such training occurs. In order to make the systems adaptable in this way, a model of the student’s characteristics - the student model - has to be set up, maintained and updated. However, there are many difficulties involved in obtaining sufficient information to create an accurate student model. One way to solve this problem is to involve students in the student modeling process, stimulating them to provide the necessary information by means of a dialog in which the student and system build the student model according to a collaborative process. The present work describes a cooperative student modeling method (Cooperative Student Assessment - CSA which builds a joint system-student assessment of student’s activities on the basis of the student’s self-assessment ability estimation and a prototype system for children, addressing the learning of fractions, in which CSA is implemented. The article also reports the result of an experimentation carried out with learners attending primary school aiming at evaluating the effectiveness of involving students in the assessment process by comparing two versions of the same system: one using cooperative student modeling and the other the traditional overlay model.

  7. Proposals for regional cooperation in Africa

    The CTBTO Prep Com is overseeing the rapid establishment of the verification-related means for the future CTBTO. It encourages support and participation in its development and would like to ensure that ancillary benefits are identified and utilised. One such benefit is to be derived from the global expertise, data and information which are developed and generated through its activities. This is particularly so in the field of seismology where the rapidly developing field of engineering seismology is dependent on quality data over an extended period. A national seismological capability is essential for countries that wish/expect to develop rapidly in the next few decades. Tremendous benefit can be derived by utilizing the verification-related monitoring data and information products of the CTBTO Prep Com, by making the organization (International Cooperation Section) aware of all national seismological needs and by interacting with member states. A regional co-operative programme or structure could be of benefit to countries to link with the CTBTO Prep Com in Vienna or for addressing problems common to a region. There are a number of regional organisations in Africa that can house or provide some form of support to further the cause of envisaged regional co-operative endeavours. The terms of reference and mechanisms by which the regional endeavours will operate should preferably be set up by the participating states within each region

  8. New cooperative seismograph networks established in southern California

    Hill, D.P.

    1974-01-01

    Southern California has more active faults located close to large, urban population centers than any other region in the United States. Reduction of risk to life and property posed by potential earthquakes along these active faults is a primary motivation for a cooperative earthquake research program between the U.S Geological Survey and major universities in Southern California. 

  9. Harvest-Then-Cooperate: Wireless-Powered Cooperative Communications

    Chen, He; Li, Yonghui; Luiz Rebelatto, Joao; Uchoa-Filho, Bartolomeu F.; Vucetic, Branka

    2015-04-01

    In this paper, we consider a wireless-powered cooperative communication network consisting of one hybrid access-point (AP), one source, and one relay. In contrast to conventional cooperative networks, the source and relay in the considered network have no embedded energy supply. They need to rely on the energy harvested from the signals broadcasted by the AP for their cooperative information transmission. Based on this three-node reference model, we propose a harvest-then-cooperate (HTC) protocol, in which the source and relay harvest energy from the AP in the downlink and work cooperatively in the uplink for the source's information transmission. Considering a delay-limited transmission mode, the approximate closed-form expression for the average throughput of the proposed protocol is derived over Rayleigh fading channels. Subsequently, this analysis is extended to the multi-relay scenario, where the approximate throughput of the HTC protocol with two popular relay selection schemes is derived. The asymptotic analyses for the throughput performance of the considered schemes at high signal-to-noise radio are also provided. All theoretical results are validated by numerical simulations. The impacts of the system parameters, such as time allocation, relay number, and relay position, on the throughput performance are extensively investigated.

  10. The Effects of Cooperative Learning on Enhancing Hong Kong Fifth Graders' Achievement Goals, Autonomous Motivation and Reading Proficiency

    Law, Yin-Kum

    2011-01-01

    Research indicates that cooperative learning with teacher-guided instruction is more effective in helping young children to learn than cooperative learning with minimal guidance. In the present study, two different cooperative learning activities (jigsaw and drama) and a control condition (a traditional teacher-led approach) were compared. The…

  11. Astronaut Gordon Cooper during flight tests

    1963-01-01

    Astronaut L. Gordon Cooper, prime pilot for the Mercury-Atlas 9 mission, relaxes while waiting for weight and balance tests to begin (03974); Cooper prior to entering the Mercury Spacecraft for a series of simulated flight tests. During these tests NASA doctors, engineers and technicians monitor Cooper's performance (03975); Cooper undergoing suit pressurization tests (03976).

  12. Culture and Cooperation during the Interwar Period

    Anişoara Popa

    2015-01-01

    Starting from the most important Publications of the International Institute for Intellectual Cooperation (1925-1946) we will explore the ideas concerning culture and personalities involved in the intellectual cooperation during the Interwar Period. Pointing out the role that the International Institute of Intellectual Cooperation had and the Romanian contribution to this cooperation is another purpose of this article.

  13. 40 CFR 1508.5 - Cooperating agency.

    2010-07-01

    ... the human environment. The selection and responsibilities of a cooperating agency are described in... 40 Protection of Environment 32 2010-07-01 2010-07-01 false Cooperating agency. 1508.5 Section... Cooperating agency. Cooperating agency means any Federal agency other than a lead agency which...

  14. 36 CFR 212.3 - Cooperative work.

    2010-07-01

    ... 36 Parks, Forests, and Public Property 2 2010-07-01 2010-07-01 false Cooperative work. 212.3... MANAGEMENT Administration of the Forest Transportation System § 212.3 Cooperative work. (a) Cooperative... for expenditure from the appropriation “Cooperative Work, Forest Service.” If a State, county or...

  15. 15 CFR 27.114 - Cooperative research.

    2010-01-01

    ... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Cooperative research. 27.114 Section... § 27.114 Cooperative research. Cooperative research projects are those projects covered by this policy which involve more than one institution. In the conduct of cooperative research projects,...

  16. 38 CFR 16.114 - Cooperative research.

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2010-07-01 2010-07-01 false Cooperative research. 16... OF HUMAN SUBJECTS § 16.114 Cooperative research. Cooperative research projects are those projects covered by this policy which involve more than one institution. In the conduct of cooperative...

  17. 28 CFR 46.114 - Cooperative research.

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Cooperative research. 46.114 Section 46... Cooperative research. Cooperative research projects are those projects covered by this policy which involve more than one institution. In the conduct of cooperative research projects, each institution...

  18. Cooperative decision making in a stochastic environment

    Suijs, J.P.M.

    1998-01-01

    Cooperative game theory is a mathematical tool to analyze situations involving several individuals who can obtain certain benefits by cooperating. The main questions this theory addresses are who will cooperate with whom and how will the corresponding benefits be divided. Most results of cooperative

  19. Co-operation - the key to success

    The Romanian nuclear power industry is still a young one. Less than six years elapsed since the Unit 1 of Cernavoda NPP started its commercial operation. Nevertheless, the performance indicators recorded by the Unit 1 during this period are very good what is doubtless the combined effect of a good design, high quality main equipment, correct installation and a very qualified, skilled operation. The cooperation established during the construction between the station's personnel, designers, equipment manufacturers and other organizations is going on and should be developed in the future during the work of Unit 2 completion which is planned to be connected to the national electricity grid by the year 2005. Preparation of that event includes recruitment of new personnel and training of the existing personnel. This process is a task of the station's Training Center which have projects in cooperation with University 'Politehnica' of Bucharest. The events in 1989 blocked for a while the activities related to Unit 2 which has been although restarted after a delay of several years. In the new circumstances, new policy concerning the profile and size of the infrastructure, particularly, the contribution of the Romanian nuclear power industry have been defined. Although, the international cooperation in this field remains a 'must', the benefits of which should be used by Romania as much as possible. This is particularly important having in view that Romania has operated only a single nuclear unit with a history of only six years of operation. Hence, the need of developing international cooperation not only with AECL - Canada and ANSALDO - Italy but also with organizations like General Electric - USA, Siemens - Germany, NEXANS -France, Furmanite - UK, etc. We have also various connections with organizations of abroad operating nuclear power stations similar with Cernavoda NPP, from Canada, Korea, Argentina, India and China. As IAEA and WANO member we hosted in Cernavoda

  20. Regional cooperation in nuclear energy development

    In November 1985, PBNCC (the Pacific Basin Nuclear Cooperation Committee) was formally established. Currently six Pacific Basin members have been participating in PBNCC: Canada, Japan, South Korea, Mexico, Taiwan of Chian, and the United States of America. The People's Republic of China has sent observes to the PBNCC meetings. The technical contents of PBWCC working groups are as follows: 1. Regional cooperative for pooled spare parts of nuclear power plants and inventory management; 2. Regional cooperation in nuclear training; 3. Regional cooperation on nuclear safety; 4. Regional cooperation in Codes and Standards; 5. Regional Cooperation in public acceptance; 6. Regional cooperation on radwaste management. (Liu)

  1. Representations of Cooperative Interactions and Their Development in Preschoolers (Representation des composantes de la cooperation au prescolaire dans des situations ludiques libres).

    Garnier, Catherine

    Six groups of children 2- to 4-years-old were videotaped and interviewed during five 30-minute free play sessions for the purpose of investigating the evolution of children's conceptions of the process of cooperation. Children's answers were organized into six themes, each of which described some aspect of cooperative activity. For each theme,…

  2. Cooperation and the common good.

    Johnstone, Rufus A; Rodrigues, António M M

    2016-02-01

    In this paper, we draw the attention of biologists to a result from the economic literature, which suggests that when individuals are engaged in a communal activity of benefit to all, selection may favour cooperative sharing of resources even among non-relatives. Provided that group members all invest some resources in the public good, they should refrain from conflict over the division of these resources. The reason is that, given diminishing returns on investment in public and private goods, claiming (or ceding) a greater share of total resources only leads to the actor (or its competitors) investing more in the public good, such that the marginal costs and benefits of investment remain in balance. This cancels out any individual benefits of resource competition. We illustrate how this idea may be applied in the context of biparental care, using a sequential game in which parents first compete with one another over resources, and then choose how to allocate the resources they each obtain to care of their joint young (public good) versus their own survival and future reproductive success (private good). We show that when the two parents both invest in care to some extent, they should refrain from any conflict over the division of resources. The same effect can also support asymmetric outcomes in which one parent competes for resources and invests in care, whereas the other does not invest but refrains from competition. The fact that the caring parent gains higher fitness pay-offs at these equilibria suggests that abandoning a partner is not always to the latter's detriment, when the potential for resource competition is taken into account, but may instead be of benefit to the 'abandoned' mate. PMID:26729926

  3. Expulsion of Members by Agricultural Cooperatives

    Copeland, John D.

    1986-01-01

    The relationship between farmer members and their cooperatives is unique, a combination of contract, business, and membership interests. Cooperatives may have occasion to terminate the relationship by expelling a member. This article explore legal authority of cooperatives to expel members, conditions under which expulsion is an acceptable action by cooperatives, and legal consequences of improper expulsion are described, and procedures are suggested to protect member and cooperative interest...

  4. Expand and extend bilateral and multilateral cooperation

    2006-01-01

    @@ Focusing on her major business subject, at the same time, NSFC strived to promote international fundamental research cooperations, seriously implemented the new-era policies, and achieved great progress in exploring international cooperation channels, organizing international cooperative projects, attracting overseas talent resources,designing the Eleventh Five-Year Plan for international cooperation, establishing constitution and exploring political strategy etc. In 2005, NSFC granted 1593 cooperation projects with a total investment of 89.7716 million RMB.

  5. The parents' opinions on cooperation with kindergarten

    Šenica, Anja

    2013-01-01

    Cooperation between kindergartens and families has been changing throughout history. People did not used to place great importance on such cooperation, but legislation today obligates kindergartens to cooperate with parents. Since it is the role of both parents and kindergarten teacher to care for and stimulate children's development, cooperation is even more important. The foundations for good cooperation are willingness on the side of parents and of teacher, mutual trust and open relationsh...

  6. Social Capital and Diversification of Cooperatives

    Deng, Wendong

    2015-01-01

    markdownabstract__Abstract__ This thesis contributes to two research streams of the literature regarding agricultural cooperatives, namely, social capital and product diversification of cooperatives. First, the thesis examines the nature of a marketing cooperative by considering both its economic and social attributes. Several formal models are formulated to address the interaction between cooperative governance structure and the different dimensions of cooperative social capital. The coopera...

  7. Hydroacoustics and infrasound: Possibilities for international cooperation

    The data provided by the International Monitoring system and the Products generated by the International data Center will be a unique source not only for CTBT verification but also for other activities. Although the utility of hydro acoustic and infrasonic data for such purposes is less obvious than that of seismic and radionuclide data, there are several possible applications for hazard and disaster warning purposes, and many potential long-term benefits for research and development. Such wider benefits from the monitoring system will best be realized through open international cooperation

  8. Cooperative sentry vehicles and differential GPS leapfrog

    FEDDEMA,JOHN T.; LEWIS,CHRISTOPHER L.; LAFARGE,ROBERT A.

    2000-06-07

    As part of a project for the Defense Advanced Research Projects Agency, Sandia National Laboratories Intelligent Systems and Robotics Center is developing and testing the feasibility of using a cooperative team of robotic sentry vehicles to guard a perimeter, perform a surround task, and travel extended distances. This paper describes the authors most recent activities. In particular, this paper highlights the development of a Differential Global Positioning System (DGPS) leapfrog capability that allows two or more vehicles to alternate sending DGPS corrections. Using this leapfrog technique, this paper shows that a group of autonomous vehicles can travel 22.68 kilometers with a root mean square positioning error of only 5 meters.

  9. Canadian involvement in international nuclear cooperation

    Since 1945 Canada has been actively involved in the development of an international consensus on measures to prevent the proliferation of nuclear weapons. In parallel with this involvement, Canada has entered into cooperative agreements with several countries under which nuclear materials, equipment and facilities have been supplied in connection with the medical, industrial, agricultural and electrical power applications of nuclear energy. This paper summarizes the actions taken by Canada to encourage the peaceful uses of nuclear energy and to avoid the spread of nuclear weapons. (author)

  10. Forskningsoversigt - Effekterne af Cooperative Learning

    Larsen, Lea Lund

    Kan Cooperative Learning - en undervisningsform hvor lærerens tid ved tavlen mindskes og hvor de lærende samarbejder om stoffet - maksimere de lærendes indlæring og medvirke til en forbedring af deres interpersonelle og kommunikative kompetencer, samt øge deres motivation for læring? Den megen...... forskning fra USA viser, at Cooperative Learning øger lærerens bevidsthed om, hvilken adfærd, han er medvirkende til at skabe blandt de lærende. Og den øger lærerens bevidsthed omkring interaktioner i klasserummet, og giver god plads og taletid til hver enkelt lærende. Set i lyset heraf kan Cooperative......, at Cooperative Learning har lige så høj grad af positiv effekt, som den viser sig at have på grundskoleområdet. Det er sigtet med denne oversigt over den empiriske forskning. Til start præsenteres Cooperative Learning som metode, dens rødder og udvikling, dernæst skitseres den omfattende forskning omkring...

  11. The Globalization of Cooperative Groups.

    Valdivieso, Manuel; Corn, Benjamin W; Dancey, Janet E; Wickerham, D Lawrence; Horvath, L Elise; Perez, Edith A; Urton, Alison; Cronin, Walter M; Field, Erica; Lackey, Evonne; Blanke, Charles D

    2015-10-01

    The National Cancer Institute (NCI)-supported adult cooperative oncology research groups (now officially Network groups) have a longstanding history of participating in international collaborations throughout the world. Most frequently, the US-based cooperative groups work reciprocally with the Canadian national adult cancer clinical trial group, NCIC CTG (previously the National Cancer Institute of Canada Clinical Trials Group). Thus, Canada is the largest contributor to cooperative groups based in the United States, and vice versa. Although international collaborations have many benefits, they are most frequently utilized to enhance patient accrual to large phase III trials originating in the United States or Canada. Within the cooperative group setting, adequate attention has not been given to the study of cancers that are unique to countries outside the United States and Canada, such as those frequently associated with infections in Latin America, Asia, and Africa. Global collaborations are limited by a number of barriers, some of which are unique to the countries involved, while others are related to financial support and to US policies that restrict drug distribution outside the United States. This article serves to detail the cooperative group experience in international research and describe how international collaboration in cancer clinical trials is a promising and important area that requires greater consideration in the future. PMID:26433551

  12. Progress report on JAERI-ORNL cooperative neutron scattering research

    One year activities done under the JAERI-DOE(ORNL) cooperative neutron scattering program are summarized. This period just followed the completion of the wide-angle neutron diffractometer dedicated to the cooperative research. The report contains results of the performance test of the instrument and early research activities. The latter part includes the time-resolved measurements of the transition kinetics in tin and Ni-Mn alloy as well as the single-crystal diffraction by the flat-cone method. (author)

  13. Nursing cooperation in endovascular aneurysm repair treatment for aortic dissection

    Objective: To summarize the main points of nursing cooperation in endovascular aneurysm repair treatment for aortic dissection. Methods: Preoperative psychological care and the other preparations were carefully conducted. During the operation, the patient's body was correctly placed. Active cooperation with the performance of angiography and close observation during heparinization were carried out. The proper delivery of catheter and stent to the operator was carefully done. Close observation for the patient's vital signs, the renal function and the changes of limb blood supply were made. Results: Under close cooperation of' the operators, nurses, anesthesiologists and technicians, the surgery was successfully accomplished in 35 patients. The monitoring of vital signs during the entire performance of operation was well executed. No surgical instruments delivery error's or surgery failure due to unsuitable cooperation occurred. Conclusion: Perfect preoperative preparation, strict nursing cooperation and team cooperation are the key points to ensure a successful endovascular aneurysm repair for aortic dissection. (authors)

  14. EMCORE - Emotional Cooperative Groupware

    Fasoli, N.; Messina, A.

    In the last years considerable effort has been spent to develop groupware applications. Despite this, no general consenus has been met by groupware applications in computer field. Interdisciplinary approach could prove very useful to overcome these difficulties. A workgroup is not simply a set of people gathered together, working for a common goal. It can also be thought as a strong, hard mental reality. Actually, sociological and psychological definitions of group differ considerably. At sociological level a group is generally described in the view of the activities and events occurring inside the group itself. On the other hand, the psychological group approach considers not only the actions occurring inside the group, but also all the mental activities originated by belonging to the group, be they emotional or rational nature. Since early '60 simple work group (i.e. discussion group) has been analyzed in his psychological behavior. EMCORE is a prototype which aims to support computer science methods with psychological approach. The tool has been developed for a discussion group supported by heterogeneous distributed systems and has been implemented according to the CORBA abstraction augmented by the machine independent JAVA language. The tool allows all the common activities of a discussion group: discussion by voice or by chatting board if multimedia device are not present; discussion and elaboration of a shared document by text and/or graphic editor. At the same time, tools are provided for the psychoanalytic approach, according to a specific methodology.

  15. INTELLIGENT RESOLUTION OF COOPERATIVE CONFLICT

    2000-01-01

    First, the concept of cooperative conflict is presented, and the characteristic of cooperative air combat is researched. Then, four methods of conflict resolution are designed by way of the first order predicate logic, I.e., link-up, coordination, accommodation and integration, and corresponding examples are given. A 2 vs 2 air combat simulation was carried out; after conflict resolution, the loss ratio is dropped to 0.54 from the original 1.32, so the enhancement of effectiveness is notable. The present research findings are that the wide conflicts discover the essence of multi-fighter cooperation, I.e., to as fully as possible enhance the effectiveness of each fighter to attain global optimization, and that the possibility of conflict resolution shows the application prospect. The proposed method in this paper is a helpful try to the application of the Fifth Generation Computer in the new generation of C3I system.

  16. Regional cooperation prospects in Korea

    The Republic of Korea follows a well-established nuclear nonproliferation policy and could consider regional cooperation as proposed by many nuclear experts over the years. Real problems exist in establishing cooperation, but as the nuclear industry continues to grow, the motivation increases. The US should be a partner in the regional cooperation also. This paper summarizes significant advances made by the NNCA in applying remote monitoring technologies to support international safeguards in the ROK, providing the technical foundation for the use of these technologies for transparency between partner countries. Concrete steps are proposed to form an institutional and then a governmental approach for transparency in the use of nuclear material and even, eventual establishment of a regional safeguards inspection regime. (author)

  17. Guiding Attention by Cooperative Cues

    KangWoo Lee

    2008-01-01

    A common assumption in visual attention is based on the rationale of "limited capacity of information pro-ceasing". From this view point there is little consideration of how different information channels or modules are cooperating because cells in processing stages are forced to compete for the limited resource. To examine the mechanism behind the cooperative behavior of information channels, a computational model of selective attention is implemented based on two hypotheses. Unlike the traditional view of visual attention, the cooperative behavior is assumed to be a dynamic integration process between the bottom-up and top-down information. Furthermore, top-down information is assumed to provide a contextual cue during selection process and to guide the attentional allocation among many bottom-up candidates. The result from a series of simulation with still and video images showed some interesting properties that could not be explained by the competitive aspect of selective attention alone.

  18. Local Water Conflict and Cooperation

    Hermann, Roberto Rivas; Hooper, Catherine; Munk Ravnborg, Helle

    2011-01-01

    governance framework in the five countries and discuss its implications. The present paper synthesizes possible ‘blind spots’ in the national policy, legal or administrative water governance frameworks with reference to the identified types of water-related conflictive and cooperative situations identified......In 2007 the Danish Institute for International Studies (DIIS) launched the research programme “Competing for Water: Understanding conflict and cooperation in local water governance”. Along with partners in five developing countries (Bolivia, Mali, Nicaragua, Vietnam and Zambia), the programme aims...... to contribute to “sustainable local water governance in support of the rural poor and otherwise disadvantaged groups in developing countries by improving the knowledge among researchers and practitioners of the nature, extent and intensity of local water conflict and cooperation and their social...

  19. Cooperative program for Asian pediatricians.

    Sakakihara, Y; Nakamura, Y

    1993-12-01

    The Cooperative Program for Asian Pediatricians (CPAP) is a non-government organization established in 1989 to promote mutual understanding and friendship among young pediatricians in Asian countries. Unlike other government programs and non-government organizations, CPAP is solely facilitating mutual relationships among young inexperienced pediatricians who would otherwise have no chance to travel overseas. It has been funded by donations from members of the alumni association of the Department of Pediatrics at the University of Tokyo and many private companies and individuals. The Cooperative Program for Asian Pediatricians has so far invited 36 Asian pediatricians from 11 countries. By constructing a human network among Asian pediatricians, it is hoped that CPAP will contribute to making international cooperation in the Asian region easier and smoother. PMID:8109248

  20. USDOE/EPRI BIOMASS COFIRING COOPERATIVE AGREEMENT

    D. Tillman; E. Hughes

    1999-01-01

    During the period of October 1, 1998 through December 31, 1998, significant work was done in direct preparation for several cofiring tests. Major progress was made on several projects including cofiring at Seward (GPU Genco), Allen (TVA), and Bailly (NIPSCO). Most of the work was focused on construction activities at the Seward and Bailly Generating Stations. The conceptual design and feasibility study for gasification-based cofiring at the Allen Fossil Plant was completed. The feasibility study for cofiring at the Pirkey and Northeastern Generating Stations of Central and South West Utilities (C&SW) also was completed. This report summarizes the activities during the fourth calendar quarter in 1998--of the USDOE/EPRI Biomass Cofiring Cooperative Agreement. It focuses upon reporting the results of construction activities and related events.