WorldWideScience

Sample records for zamani huecejre qomeostasinin

  1. From Point Cloud to Textured Model, the Zamani Laser Scanning ...

    African Journals Online (AJOL)

    roshan

    meshed models based on dense points has received mixed reaction from the wide range of potential end users of the final ... data, can be subdivided into the stages of data acquisition, registration, data cleaning, modelling, hole filling ..... provide management tools for site management at local and regional level. The project ...

  2. GÜNEY MARMARA BÖLGESİNDEKİ BÜYÜK VADİLERİN OLASI DEŞİLME ZAMANI

    Directory of Open Access Journals (Sweden)

    Nizamettin KAZANCI

    2014-06-01

    Full Text Available Güney Marmara Bölgesi’nin (Susurluk drenaj havzası-SDH suları ve tortulları büyük ölçüde önce Manyas ve Ulubat göllerinde toplanır, sonra tek kanaldan Marmara Denizi’ne ulaşır.Mevcut akaçlama sistemi ile buradaki gözlem istasyonları SDH’ndaki aşınma hızını ve dolayısıyla buradaki büyük ölçekli vadilerin kazınma sürelerini araştırma olanağı vermektedir. Bu yönde veri elde etmek için, Ulubat Gölü’nün eski tortulları ve bunların kimyasal kapsamları sondajlar yardımıyla çalışılmıştır. Karotlarla kesilen göl tortulları içindeki bor iyonu alttan üste doğru 4 m seviyesinde aniden artmakta olup bu değişme Emet Vadisi’ndeki borat yataklarının aşınmaya başlamasıyla ortaya çıkmıştır. Aşınma-depolanma ilişkileri dikkate alınarak Emet Vadisi’ndeki deşilme hızı 1,4 cm/yıl, bu değerin tüm araziye uygulanmasıyla vadinin toplam kazılma süresi 75 bin yıl olarak hesaplanmaktadır. Jeolojik süreçlerin tekdüze olmadığı dikkate alınarak, bu yaşın mutlak olmayacağı, ancak mevcut taşınma ve depolanma hızlarına göre vadilerin kazılma süresinin 300 bin yıldan daha da geriye gitmeyeceği söylenebilir. Öyle anlaşılıyor ki, hızlı aşınmanın önemli nedenlerinden birisi Marmara Denizi’nin son Buzul Çağında göl halinde oluşudur. Alçak taban düzeyi, kaynak alan ile birikim yeri arasında belirgin yükseklik farkı yaratmış ve erozyonun hızlanmasına yol açmıştır..

  3. ERZURUM ŞARTLARINDA DİKİM ZAMANI VE TEPE ALMANIN PATATESTE VERİM VE ÇEŞİTLİ ÖZELLİKLERİNE ETKİSİ /

    OpenAIRE

    Şenol, Sabahattin

    2010-01-01

    ÖZETErzurum Ekolojik şartlarında dikim ve tepe alma zamanmm patatesteverime ve diğer bazı agronomik karekterlere etkisini tesbitetmek için bu çalışma yapılmış, erkenci ve geç olgunlaşan 34/962 ve49/962 çeşitler bu denemeye alınmıştır. Neticede, en fazıa verim enerken dikim zamanı olarak tayin ediıen 13 Mayıs tarihinde a.ltlnmış,tepe aımanm· veya sürgün öıdürmenin önemli etkisi g&ou...

  4. Determination of Synthetic Food Colors, Caffeine, Sodium Benzoate ...

    African Journals Online (AJOL)

    Determination of Synthetic Food Colors, Caffeine, Sodium Benzoate and Potassium Sorbate in Sports Drinks. Fatemeh Zamani Mazdeh, Zeinab Moradi, Ghazaleh Moghaddam, Zhila Moradi-Khatoonabadi, Farideh Esmaeili Aftabdari, Parnaz Badaei, Mannan Hajimahmoodi ...

  5. Fulltext PDF

    Indian Academy of Sciences (India)

    Elasto-plastic strain analysis by a semi-analytical method .... forced plastic laminates to strengthen steel ... Micro and macro contact mechanics for inter- ... soil. 781. Zamani M. A more general model for the analysis of the rock slope stability.

  6. Scientific Letter: Stabbing nails into the neck: an unusual self ...

    African Journals Online (AJOL)

    Scientific Letter: Stabbing nails into the neck: an unusual self-damaging behavior mandating neurosurgery. A Aghabiklooei, R Aghabiklooei, N Zamani. Abstract. Scientific Letter - No Abstract Available. Full Text: EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT.

  7. KISWAHILI AU KIINGEREZA? SIASA NA LUGHA MUAFAKA YA ...

    African Journals Online (AJOL)

    Madhumuni ya makala hii ni kuonyesha kuwa wataalam wenye wajibu wa kushughulikia tatizo la utayari wa Kiswahili katika elimu walishamaliza kazi yao zamani na wakabainisha kuwa, kwa Tanzania, Kiswahili kikitumika mara moja katika mfumo mzima wa elimu badala ya Kiingereza au lugha nyingine, mabadiliko ya ...

  8. African Journal of Psychiatry - Vol 16, No 3 (2013)

    African Journals Online (AJOL)

    Scientific Letter: Stabbing nails into the neck: an unusual self-damaging behavior mandating neurosurgery · EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. A Aghabiklooei, R Aghabiklooei, N Zamani, 169-171. http://dx.doi.org/10.4314/ajpsy.v16i3.21 ...

  9. Effect of Drying Conditions on the Catalytic Performance, Structure, and Reaction Rates over the Fe-Co-Mn/MgO Catalyst for Production of Light Olefins

    Directory of Open Access Journals (Sweden)

    Majid Abdouss

    2018-01-01

    How to Cite: Abdouss, M., Arsalanfar, M., Mirzaei, N., Zamani, Y. (2018. Effect of Drying Conditions on the Catalytic Performance, Structure, and Reaction Rates over the Fe-Co-Mn/MgO Catalyst for Production of Light Olefins. Bulletin of Chemical Reaction Engineering & Catalysis, 13 (1: 97-112 (doi:10.9767/bcrec.13.1.1222.97-112

  10. Browse Author Index

    African Journals Online (AJOL)

    Z. Zabow, Tuviah · Zachariah, MP · Zamani, N · Zergew, A · Zubaran, C · Zullino, DF 1 - 6 of 6 Items. ISSN: 1994-8220. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and Conditions of Use · Contact AJOL · News. OTHER ...

  11. Comparison effectiveness of Dialectic Behavioral Therapy and Behavior Cognitive Therapy on Depression in the Multiple sclerosis

    OpenAIRE

    Narges Zamani; Mehran Farhadi; Hosein Jenaabadi

    2017-01-01

    Balsimelli S, Mendes MF, Bertolucci PH, Tilbery CP. Attention impairment associated with relapsing-remitting multiple sclerosis patients with mild incapacity. Arq Neuropsiquiatr 2007;65(2A):262-7. Zamani N, Ahmadi V, Ataie Moghanloo V, Mirshekar S. Comparing the effectiveness of two therapeutic methods of dialectical behavior therapy and cognitive behavior therapy on the improvement of impulsive behavior in the patients suffering  from major depressive disorder (MDD) showing a t...

  12. Control Adaptativo Fraccionario Optimizado por Algoritmos Genéticos, Aplicado a Reguladores Automáticos de Voltaje

    Directory of Open Access Journals (Sweden)

    Marco E. Ortiz-Quisbert

    2016-10-01

    Full Text Available Resumen: En este trabajo se presenta la técnica del control adaptable de orden fraccionario por modelo de referencia (CAOFMR, aplicada a los reguladores automáticos de voltaje (RAV. El artículo se enfoca en el ajuste de las ganancias adaptables y los órdenes de derivación de las leyes de ajuste del controlador CAOFMR, determinados por la minimización de una función criterio definida para el modelo simplificado del RAV, mediante la utilización de la técnica de optimización de algoritmos genéticos (AG. En base a un criterio de evaluación propuesto por otros autores, se realizan comparaciones, por medio de simulaciones, de la técnica de control propuesta con los resultados obtenidos por la técnica de control PID de orden entero (OEPID (Zamani et al., 2009. Se muestra que el controlador CAOFMR con parámetros optimizados por AG, entrega mejores resultados en términos de robustez frente a variaciones en los parámetros del sistema controlado y mejoras en relación a la velocidad de convergencia hacia las señales de referencia del sistema RAV. Abstract: The technique Fractional Order Model Reference Adaptive Control (FOMRAC applied to an Automatic Voltage Regulator (AVR is presented in this paper. The work is focused on tuning the adaptive gains and the derivation order of the adaptive laws of the FOMRAC, determined through the minimization of a criterion function defined for the simplified model of the AVR, by means of the genetic algorithm (GA optimization technique. Based on the criterion function proposed by other authors a simulated comparative study is performed, comparing the proposed methodology with the integer order PID control reported in (Zamani et al., 2009. It is shown that the FOMRAC with parameters optimized by GA provides better results in terms of robustness under parameters variations of the system under control and improvements in the convergence speed of the control error. Palabras clave: Control Adaptativo de

  13. Physical activity and self-esteem: testing direct and indirect relationships associated with psychological and physical mechanisms

    Directory of Open Access Journals (Sweden)

    Zamani Sani SH

    2016-10-01

    Full Text Available Seyed Hojjat Zamani Sani,1 Zahra Fathirezaie,1 Serge Brand,2 Uwe Pühse,3 Edith Holsboer-Trachsler,2 Markus Gerber,3 Siavash Talepasand4 1Department of Motor Behavior, Faculty of Physical Education and Sport Science, University of Tabriz, Tabriz, Iran; 2Psychiatric Clinics of the University of Basel, Center for Affective, Stress and Sleep Disorders (ZASS, 3Department of Sport, Exercise and Health, Sport Science Section, University of Basel, Basel, Switzerland; 4Department of Psychology and Educational Sciences, Semnan University, Semnan, Iran Abstract: In the present study, we investigated the relationship between physical activity (PA and self-esteem (SE, while introducing body mass index (BMI, perceived physical fitness (PPF, and body image (BI in adults (N =264, M =38.10 years. The findings indicated that PA was directly and indirectly associated with SE. BMI predicted SE neither directly nor indirectly, but was directly associated with PPF and both directly and indirectly with BI. Furthermore, PPF was directly related to BI and SE, and a direct association was found between BI and SE. The pattern of results suggests that among a sample of adults, PA is directly and indirectly associated with SE, PPF, and BI, but not with BMI. PA, PPF, and BI appear to play an important role in SE. Accordingly, regular PA should be promoted, in particular, among adults reporting lower SE. Keywords: physical activity, self-esteem, physical fitness, body image, adults

  14. Comparison effectiveness of Dialectic Behavioral Therapy and Behavior Cognitive Therapy on Depression in the Multiple sclerosis

    Directory of Open Access Journals (Sweden)

    Narges Zamani

    2017-03-01

    Full Text Available Balsimelli S, Mendes MF, Bertolucci PH, Tilbery CP. Attention impairment associated with relapsing-remitting multiple sclerosis patients with mild incapacity. Arq Neuropsiquiatr 2007;65(2A:262-7. Zamani N, Ahmadi V, Ataie Moghanloo V, Mirshekar S. Comparing the effectiveness of two therapeutic methods of dialectical behavior therapy and cognitive behavior therapy on the improvement of impulsive behavior in the patients suffering  from major depressive disorder (MDD showing a tendency to suicide. J Ilam Univ Med Sci 2014;22(5:45-54. [Full Text in Persian] Sadovnick AD. European charcot foundation lecture: The natural history of multiple sclerosis and gender. J Neurol Sci 2009;286(1-2:1-5. Robins LN. Psychiatric epidemiology. Arch Gen Psychiatry 1984;41(10:931-33. Amato MP, Ponziani G, Siracusa G, Sorbi S. Cognitive dysfunction in early-onset multiple sclerosis. Arch Neurol 2001;58(10:1602-6.  Polman CH, Reingold SC, Banwell B, Michel Clanet M, Cohen JA, Filippi M, et al. Diagnostic criteria for multiple sclerosis: Revisions to the McDonald Criteria. Ann Neurol 2011;69(2:292–302. Zamani N, Farhadi M, Jamilian HR, Habibi M. Effectiveness of dialectical behavior group therapy on expulsive anger. J Arak Univ Med Sci 2015;8(101:35-44. [Full Text in Persian] Young JE, Klosko JS, Weishaar ME. Schema therapy: A Practitioner’s guide. Translated by: Hamidpoor H. New York: Guilford Press; 2003. Linehan M. Dialectical Behavior therapy frequently Asked Questions. Avalaible From: http://behavioraltech.org/downloads/dbtFaq_Cons.pdf. Accessed Sep, 2008. Zamani N, Habibi M, Darvishi M. To compare the effectiveness dialectical behavior therapy and cognitive-behavioral group therapy in reducing depression in mothers of children with disabilities. Arak Med Univ J 2015;18(94:32-42. [Full Text in Persian] Hawton K, Salkous K, Clarck. Cognitive Behavior Therapy for psychiatric problems, a practical guide. Translated by: Ghasemzadeh H. Tehran: Arjomand Pub; 2002

  15. MER SPICE Interface

    Science.gov (United States)

    Sayfi, Elias

    2004-01-01

    MER SPICE Interface is a software module for use in conjunction with the Mars Exploration Rover (MER) mission and the SPICE software system of the Navigation and Ancillary Information Facility (NAIF) at NASA's Jet Propulsion Laboratory. (SPICE is used to acquire, record, and disseminate engineering, navigational, and other ancillary data describing circumstances under which data were acquired by spaceborne scientific instruments.) Given a Spacecraft Clock value, MER SPICE Interface extracts MER-specific data from SPICE kernels (essentially, raw data files) and calculates values for Planet Day Number, Local Solar Longitude, Local Solar Elevation, Local Solar Azimuth, and Local Solar Time (UTC). MER SPICE Interface was adapted from a subroutine, denoted m98SpiceIF written by Payam Zamani, that was intended to calculate SPICE values for the Mars Polar Lander. The main difference between MER SPICE Interface and m98SpiceIf is that MER SPICE Interface does not explicitly call CHRONOS, a time-conversion program that is part of a library of utility subprograms within SPICE. Instead, MER SPICE Interface mimics some portions of the CHRONOS code, the advantage being that it executes much faster and can efficiently be called from a pipeline of events in a parallel processing environment.

  16. Domination Game: Extremal Families for the 3/5-Conjecture for Forests

    Directory of Open Access Journals (Sweden)

    Henning Michael A.

    2017-05-01

    Full Text Available In the domination game on a graph G, the players Dominator and Staller alternately select vertices of G. Each vertex chosen must strictly increase the number of vertices dominated. This process eventually produces a dominating set of G; Dominator aims to minimize the size of this set, while Staller aims to maximize it. The size of the dominating set produced under optimal play is the game domination number of G, denoted by γg(G. Kinnersley, West and Zamani [SIAM J. Discrete Math. 27 (2013 2090-2107] posted their 3/5-Conjecture that γg(G ≤ ⅗n for every isolate-free forest on n vertices. Brešar, Klavžar, Košmrlj and Rall [Discrete Appl. Math. 161 (2013 1308-1316] presented a construction that yields an infinite family of trees that attain the conjectured 3/5-bound. In this paper, we provide a much larger, but simpler, construction of extremal trees. We conjecture that if G is an isolate-free forest on n vertices satisfying γg(G = ⅗n, then every component of G belongs to our construction.

  17. Composite poly(vinyl alcohol/poly(vinyl acetate electrospun nanofibrous mats as a novel wound dressing matrix for controlled release of drugs

    Directory of Open Access Journals (Sweden)

    Jannesari M

    2011-05-01

    Full Text Available Marziyeh Jannesari1, Jaleh Varshosaz2, Mohammad Morshed1, Maedeh Zamani11Department of Textile Engineering, Isfahan University of Technology, Isfahan, Iran; 2Department of Pharmaceutics, School of Pharmacy and Pharmaceutical Sciences Research Center, Isfahan University of Medical Sciences, Isfahan, IranAbstract: The aim of this study was to develop novel biomedicated nanofiber electrospun mats for controlled drug release, especially drug release directly to an injury site to accelerate wound healing. Nanofibers of poly(vinyl alcohol (PVA, poly(vinyl acetate (PVAc, and a 50:50 composite blend, loaded with ciprofloxacin HCl (CipHCl, were successfully prepared by an electrospinning technique for the first time. The morphology and average diameter of the electrospun nanofibers were investigated by scanning electron microscopy. X-ray diffraction studies indicated an amorphous distribution of the drug inside the nanofiber blend. Introducing the drug into polymeric solutions significantly decreased solution viscosities as well as nanofiber diameter. In vitro drug release evaluations showed that both the kind of polymer and the amount of drug loaded greatly affected the degree of swelling, weight loss, and initial burst and rate of drug release. Blending PVA and PVAc exhibited a useful and convenient method for electrospinning in order to control the rate and period of drug release in wound healing applications. Also, the thickness of the blend nanofiber mats strongly influenced the initial release and rate of drug release.Keywords: biodegradable polymers, drug delivery, controlled release, electrospun nanofibers, wound dressing

  18. A revision of the spider genus Raveniola (Araneae, Nemesiidae. I. Species from Western Asia

    Directory of Open Access Journals (Sweden)

    Sergei Zonstein

    2018-01-01

    Full Text Available The genus Raveniola Zonstein, 1987 is found to be represented in Western Asia by 16 species: ♂♀ R. adjarica sp. nov. (Georgia, ♂ R. anadolu sp. nov. (Turkey, ♂ R. arthuri Kunt & Yağmur, 2010 (Turkey, ♂ R. birecikensis sp. nov. (Turkey, ♂♀ R. dunini sp. nov. (Armenia, Azerbaijan, Iran, ♂♀ R. hyrcanica Dunin, 1988 (Azerbaijan, ♂ R. marusiki sp. nov. (Iran, ♂ R. mazandaranica Marusik, Zamani & Mirshamsi, 2014 (Iran, ♂♀ R. micropa (Ausserer, 1871 (Turkey, ♀ R. nana sp. nov. (Turkey, ♂♀ R. niedermeyeri (Brignoli, 1972 (Iran, ♂♀ R. pontica (Spassky, 1937 (Russia, Georgia, ♀ R. sinani sp. nov. (Turkey, ♂♀ R. turcica sp. nov. (Turkey, ♂♀ R. vonwicki Zonstein, 2000 (Iran and ♂♀ R. zaitzevi (Charitonov, 1948 (Azerbaijan, Georgia = ♀ Brachythele recki Mcheidze, 1983, syn. nov. Eight species are newly described; others are redescribed from types and/or conspecific material. Males of R. micropa and R. zaitzevi, hitherto unknown, are described for the first time. Data on the variability, relationships, distribution, and ecology of all considered species are also provided.

  19. Examination of Sarcocystis spp. of giant snakes from Australia and Southeast Asia confirms presence of a known pathogen - Sarcocystis nesbitti.

    Directory of Open Access Journals (Sweden)

    Marion Wassermann

    Full Text Available We examined Sarcocystis spp. in giant snakes from the Indo-Australian Archipelago and Australia using a combination of morphological (size of sporocyst and molecular analyses. We amplified by PCR nuclear 18S rDNA from single sporocysts in order to detect mixed infections and unequivocally assign the retrieved sequences to the corresponding parasite stage. Sarcocystis infection was generally high across the study area, with 78 (68% of 115 examined pythons being infected by one or more Sarcocystis spp. Among 18 randomly chosen, sporocyst-positive samples (11 from Southeast Asia, 7 from Northern Australia the only Sarcocystis species detected in Southeast Asian snakes was S. singaporensis (in reticulated pythons, which was absent from all Australian samples. We distinguished three different Sarcocystis spp. in the Australian sample set; two were excreted by scrub pythons and one by the spotted python. The sequence of the latter is an undescribed species phylogenetically related to S. lacertae. Of the two Sarcocystis species found in scrub pythons, one showed an 18S rRNA gene sequence similar to S. zamani, which is described from Australia for the first time. The second sequence was identical/similar to that of S. nesbitti, a known human pathogen that was held responsible for outbreaks of disease among tourists in Malaysia. The potential presence of S. nesbitti in Australia challenges the current hypothesis of a snake-primate life cycle, and would have implications for human health in the region. Further molecular and biological characterizations are required to confirm species identity and determine whether or not the Australian isolate has the same zoonotic potential as its Malaysian counterpart. Finally, the absence of S. nesbitti in samples from reticulated pythons (which were reported to be definitive hosts, coupled with our phylogenetic analyses, suggest that alternative snake hosts may be responsible for transmitting this parasite in Malaysia.

  20. Examination of Sarcocystis spp. of giant snakes from Australia and Southeast Asia confirms presence of a known pathogen - Sarcocystis nesbitti.

    Science.gov (United States)

    Wassermann, Marion; Raisch, Lisa; Lyons, Jessica Ann; Natusch, Daniel James Deans; Richter, Sarah; Wirth, Mareike; Preeprem, Piyarat; Khoprasert, Yuvaluk; Ginting, Sulaiman; Mackenstedt, Ute; Jäkel, Thomas

    2017-01-01

    We examined Sarcocystis spp. in giant snakes from the Indo-Australian Archipelago and Australia using a combination of morphological (size of sporocyst) and molecular analyses. We amplified by PCR nuclear 18S rDNA from single sporocysts in order to detect mixed infections and unequivocally assign the retrieved sequences to the corresponding parasite stage. Sarcocystis infection was generally high across the study area, with 78 (68%) of 115 examined pythons being infected by one or more Sarcocystis spp. Among 18 randomly chosen, sporocyst-positive samples (11 from Southeast Asia, 7 from Northern Australia) the only Sarcocystis species detected in Southeast Asian snakes was S. singaporensis (in reticulated pythons), which was absent from all Australian samples. We distinguished three different Sarcocystis spp. in the Australian sample set; two were excreted by scrub pythons and one by the spotted python. The sequence of the latter is an undescribed species phylogenetically related to S. lacertae. Of the two Sarcocystis species found in scrub pythons, one showed an 18S rRNA gene sequence similar to S. zamani, which is described from Australia for the first time. The second sequence was identical/similar to that of S. nesbitti, a known human pathogen that was held responsible for outbreaks of disease among tourists in Malaysia. The potential presence of S. nesbitti in Australia challenges the current hypothesis of a snake-primate life cycle, and would have implications for human health in the region. Further molecular and biological characterizations are required to confirm species identity and determine whether or not the Australian isolate has the same zoonotic potential as its Malaysian counterpart. Finally, the absence of S. nesbitti in samples from reticulated pythons (which were reported to be definitive hosts), coupled with our phylogenetic analyses, suggest that alternative snake hosts may be responsible for transmitting this parasite in Malaysia.

  1. Frequency of medication errors in an emergency department of a large teaching hospital in southern Iran

    Directory of Open Access Journals (Sweden)

    Vazin A

    2014-12-01

    Full Text Available Afsaneh Vazin,1 Zahra Zamani,1 Nahid Hatam2 1Department of Clinical Pharmacy, Faculty of Pharmacy, 2School of Management and Medical Information Sciences, Shiraz University of Medical Sciences, Shiraz, Iran Abstract: This study was conducted with the purpose of determining the frequency of medication errors (MEs occurring in tertiary care emergency department (ED of a large academic hospital in Iran. The incidence of MEs was determined through the disguised direct observation method conducted by a trained observer. A total of 1,031 medication doses administered to 202 patients admitted to the tertiary care ED were observed over a course of 54 6-hour shifts. Following collection of the data and analysis of the errors with the assistance of a clinical pharmacist, frequency of errors in the different stages was reported and analyzed in SPSS-21 software. For the 202 patients and the 1,031 medication doses evaluated in the present study, 707 (68.5% MEs were recorded in total. In other words, 3.5 errors per patient and almost 0.69 errors per medication are reported to have occurred, with the highest frequency of errors pertaining to cardiovascular (27.2% and antimicrobial (23.6% medications. The highest rate of errors occurred during the administration phase of the medication use process with a share of 37.6%, followed by errors of prescription and transcription with a share of 21.1% and 10% of errors, respectively. Omission (7.6% and wrong time error (4.4% were the most frequent administration errors. The less-experienced nurses (P=0.04, higher patient-to-nurse ratio (P=0.017, and the morning shifts (P=0.035 were positively related to administration errors. Administration errors marked the highest share of MEs occurring in the different medication use processes. Increasing the number of nurses and employing the more experienced of them in EDs can help reduce nursing errors. Addressing the shortcomings with further research should result in reduction

  2. A novel diblock copolymer of (monomethoxy poly [ethylene glycol]-oleate with a small hydrophobic fraction to make stable micelles/polymersomes for curcumin delivery to cancer cells

    Directory of Open Access Journals (Sweden)

    Erfani-Moghadam V

    2014-11-01

    Full Text Available Vahid Erfani-Moghadam,1,6 Alireza Nomani,2 Mina Zamani,3 Yaghoub Yazdani,4 Farhood Najafi,5 Majid Sadeghizadeh1,3 1Department of Nanobiotechnology, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran; 2Department of Pharmaceutics, Faculty of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran; 3Department of Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran; 4Infectious Diseases Research Center and Laboratory Science Research Center, Golestan University of Medical Sciences, Gorgan, Golestan, Iran; 5Department of Resin and Additives, Institute for Color Science and Technology, Tehran, Iran; 6Department of Biotechnology, Faculty of Advanced Medical Technology, Golestan University of Medical Sciences, Gorgan, Iran Abstract: Curcumin is a potent natural anticancer agent, but its effectiveness is limited by properties such as very low solubility, high rate of degradation, and low rate of absorption of its hydrophobic molecules in vivo. To date, various nanocarriers have been used to improve the bioavailability of this hydrophobic biomaterial. This study investigates the encapsulation of curcumin in a novel nanostructure of monomethoxy poly(ethylene glycol-oleate (mPEG-OA and its anticancer effect. Tests were done to determine the critical micelle concentration (CMC, encapsulation efficiency, drug-loading efficiency, and cytotoxicity (against U87MG brain carcinoma cells and HFSF-PI3 cells as normal human fibroblasts of some nanodevice preparations. The results of fluorescence microscopy and cell-cycle analyses indicated that the in vitro bioavailability of the encapsulated curcumin was significantly greater than that of free curcumin. Cytotoxicity evaluations showed that half maximal inhibitory concentrations of free curcumin and curcumin-loaded mPEG-OA for the U87MG cancer cell line were 48 µM and 24 µM, respectively. The Annexin-V-FLUOS assay was used to quantify the apoptotic

  3. Dergilerden Özetler

    Directory of Open Access Journals (Sweden)

    Şebnem Korur Fincancı

    1999-04-01

    Full Text Available BİYOLUMİNESAN İLE BEYİNDE ATP DÜZEYİ ÇALIŞMASI: ÖLÜM ZAMANI BELİRLEME YÖNTEMİ Study on cerebral ATP level with bioluminescent: method to estimate the time of death "Makale Çincedir" Cben Y. Fa I Hsueh Tsa Chih 1997;13(3>138-9. Bu yazı değişik ölüm zamanlarında köpek beynindeki ATP düzeylerini bildirmektedir. ATP düzeyleri biyoluminesan yöntemi ile saptanmıştır. Sonuçlar ATP konsantrasyonunun ölüm zamanı ile birlikte yavaşça azaldığını göstermiştir. Adli uygulamada ölüm zamanının belirlenmesi için bu çalışma değer taşımaktadır. SÜTÇOCUĞU VE KÜÇÜK ÇOCUKLARIN KAZADIŞI KAFA TRAVMASINDA YARALANMA ıLE AĞIR SEMPTOMLAR ARASINDA GEÇEN ZAMAN Interval duration between injury and severe symptoms in nonaccidental head trauma in infants and young children. Gilliland MG. J Forensic Sci. 1998 May;43(3:723-5. Adli patologların sık sık çocuk istismarındaki kafa travması ölümlerinde yaralanma ile semptomların ortaya çıkışı arasında geçen zamanı belirlemeleri istenmektedir. Bu bilgilerin elde edilebildiği 76 kafa travması ile ölüm olgusunda yaralanmadan semptomların ortaya çıkışına kadar geçen süre, prospektif bir postmortem çalışmada araştırılmıştır. Kafa travması ölümleri yaralanma mekanizmasına göre sınıflan- mıştır. Mekanizmalar saısma(darbe yok, sarsma ve künt darbe birlikte ve künt darbe(sarsma öyküsü yok idi. Sarsma olgularının %80’inde, birlikte olanda %71.9 ve künt travmada % 69.2’sinde geçen zaman 24 saatten azdı. Son iki grubun herbirinin %25’inclen fazlasında geçen zaman 24 saatten fazla ve 4 çocukta da 72 saatten daha geçti. Yaralanma ile semptomların ortaya çıkışı arasındaki zamanın değişkenliği bu konuda yapılacak değerlendirmelerin ihtiyatlı olması gerektiğini göstermektedir. Bilginin fail dışında kişilerden alındığı tüm olgularda çocuğun bu zaman diliminde normal olmadığının

  4. Dergilerden Özetler

    Directory of Open Access Journals (Sweden)

    Zeki Kır

    2006-04-01

    ın mağdurlara oranla daha gençtiler. Erkek mağdurlar yaş itibariyle ya çok genç ya da çok yaşlı olmaktaydılar. En genç mağdur 2 aylık erkek bir bebekken en yaşlı mağdur ise 95 yaşındaki bir kadındı. Her bir vakada erkek faillerin oranı kadın faillere oranla 1,4 kat daha fazlaydı. Kadınların çoğunda ısırık izleri göğüs üzerinde bulunmakla beraber yaşlı erkeklerde en fazla kollar üzerinde bulunmaktaydı. Veriler bize ısırık izlerinin lokalizasyonunun suçun cinsi ve mağdurun yaşı ile bağlantılı olduğunu ortaya koydu. KISMEN BİLİNEN ÇEVRE KOŞULLARI İLE ISI ÖLÇÜMLERİNE DAYANAN ÖLÜM ZAMANI TESPİTİ IntJ Legal Med. 2005;119(4:185-94 Temperature-based death time estimation with only partially known environmental conditions Vücut ısısı ölçümlerine dayanarak yapılan ölüm zamanı tahmini rektal ısı ölçümlerinin matematiksel modeller üzerinde kullanılması esasma dayanır. Bütün matematiksel modellerde çevre ısısının bilinmesi tahminde bulunmak için şarttır. Ancak adli tıp pratiğinde olay yeri incelemelerinde her zaman çevre şartları hesaba katılarak incelemeler yapılmadığından, ölüm zamanı tahmininde bu metodun kullanılması doğru sonuçlar vermeyebilir. Çalışmamızda Henssge metodu kullanarak 35 vakadan rektal ısı ölçümleri yaptık. Bütün vakalarda ölüm zamanı kesin olarak biliniyordu. Adli Tıp Enstitüsünden gerekli izinleri aldıktan sonra vakalar çevre ortamına bırakıldı. 12-36 saatlik zaman dilimlerinde sürekli rektal ısı ölçümleri yapıldı. Ölçüm sonuçlarının değerlendirilmesi çevre şartları bilinmeden yapıldı. Elde edilen veriler istatistiksel olarak değerlendirildi. Çevre ısısı bilinmeden Henssge modeli kullanılarak yapılan ölçüm sonuçları değerlendirildiğinde %95 oranında + 4 saatlik yanılma paylarıyla doğruluk sağlandığı görüldü. Bu metot olay yeri incelemeleri esnasında rektal ve çevre ısı