Venekeelse meedia areng Eestis 1987-2004 / Valeria Jakobson

Index Scriptorium Estoniae

Jakobson, Valeria, 1972-

2004-01-01

Ülevaade venekeelse massimeedia süsteemist, venekeelse trükiajakirjanduse arengust siirdeajal, omandivormidest, Eesti venekeelsete ja Venemaa ajalehtede koostöövormidest, venekeelsest ringhäälingust Eestis, venekeelse auditooriumi eripärast. Diagrammid. Tabelid. Graafik

Measurement of probability distributions for internal stresses in dislocated crystals

Energy Technology Data Exchange (ETDEWEB)

Wilkinson, Angus J.; Tarleton, Edmund; Vilalta-Clemente, Arantxa; Collins, David M. [Department of Materials, University of Oxford, Parks Road, Oxford OX1 3PH (United Kingdom); Jiang, Jun; Britton, T. Benjamin [Department of Materials, Imperial College London, Royal School of Mines, Exhibition Road, London SW7 2AZ (United Kingdom)

2014-11-03

Here, we analyse residual stress distributions obtained from various crystal systems using high resolution electron backscatter diffraction (EBSD) measurements. Histograms showing stress probability distributions exhibit tails extending to very high stress levels. We demonstrate that these extreme stress values are consistent with the functional form that should be expected for dislocated crystals. Analysis initially developed by Groma and co-workers for X-ray line profile analysis and based on the so-called “restricted second moment of the probability distribution” can be used to estimate the total dislocation density. The generality of the results are illustrated by application to three quite different systems, namely, face centred cubic Cu deformed in uniaxial tension, a body centred cubic steel deformed to larger strain by cold rolling, and hexagonal InAlN layers grown on misfitting sapphire and silicon carbide substrates.

Meie riigi imelised muutumised : ¡[luuletused] / Valeria Ränik

Index Scriptorium Estoniae

Ränik, Valeria, 1964-

2007-01-01

Sisu: Meie riigi imelised muutumised ; "Nad ütlevad..." ; Konna-eri? Eri-konnad? ; "Kõik huvitav on juba toimunud..." ; "Üks väike Berliinike..." ; "Toomemäel karjuvad linnud..." ; (H)unt ja susi ; "Kartulid..." ; Sind kardan, Tallinn

Grid Scale Energy Storage (Symposium EE8)

Science.gov (United States)

2016-06-01

any one of the areas 5 touched upon by speakers participated in symposium EE8, which could potentially change the energy storage landscape in an...Solid-State Supercapacitors Based on RuO2/PEDOT Hybrid Ultrathin Films Chuanfang (John) Zhang1, Thomas Higgins1, Jonathan Coleman1, Valeria...or capacitance) at the expense of electrodes transmittance. Therefore it’s very necessary to develop ultrathin films with highly pseudocapacitive

Selgusid kirjandusaasta tegijad : erakordne on see, et tänavustest kirjanduspreemia saajatest on pooled naised, arvab auhinnažürii esimees Mall Jõgi / Mall Jõgi

Index Scriptorium Estoniae

Jõgi, Mall, 1947-

2001-01-01

Proosa - Andrus Kivirähk "Rehepapp". Luule - Hando Runnel "Mõistatused". Näitekirjandus - Mart Kivastik "Näidendid". Esseistika - Maie Kalda "Mis mees ta on?". Lastekirjandus - Valeria Ränik "Ülejõel, Kassilaiu pealinnas". Tõlge eesti keelde - Krista Kaer (tõlked inglise keelest: Doris Lessingi "Kuldne märkmeraamat" ja J. K. Rowling'i Harry Potteri lood). Tõlge eesti keelest - Mai Bereczki (ungarikeelse eesti luule antoloogia "Kellade hellus" I-II koostamine)

Reino Fungi: morfologías y estructuras de los hongos

OpenAIRE

Kuhar, José Francisco; Castiglia, Valeria Carolina; Papinutti, Victor Leandro

2016-01-01

Fil: Kuhar, José Francisco. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Biodiversidad y Biología Experimental. Laboratorio de Micologia Experimental; Argentina Fil: Castiglia, Valeria Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Plantas Tóxicas y Medicinales, Metabolismo de Compuestos Sintéticos y Naturales - Hongos Que Intervienen En la Degradación Biológica; Ar...

Laying Out Land Parcels and the Oldest Boundary Stone in Croatia from the 4th Century BC

Directory of Open Access Journals (Sweden)

Miljenko Solarić

2009-12-01

Full Text Available Geographical position of the Chora Pharos (nowadays Starogradsko polje, climate conditions and brief historical development of colonization on the island of Hvar are described in the paper. Also described is how Greek from the island of Paros established the town Pharos (today’s Stari Grad and how they constructed Chora Pharos (today’s Starogradsko polje. They divided the field Starogradsko polje into rectangular parcels with dimensions 1 Greek stage × 5 Greek stage (181 m × 905 m. The large project “Starogradsko polje” demonstrated that one Pharos foot equals 0.3026 m. They used the groma for pegging out orthogonal angles. Finally, there is a photograph of the boundary stone from the Chora Pharos (Starogradsko polje from the 4th century before Christ which is deposited in the Archaeological Museum in Zagreb. This is the oldest boundary stone in Croatia and as geodesists, we can consider it a geodetic monument.

Motivation to change and posttreatment temptation to drink: a multicenter study among alcohol-dependent patients

OpenAIRE

Fiabane,Elena; Ottonello,Marcella; Zavan,Valeria; Pistarini,Caterina; Giorgi,Ines

2017-01-01

Elena Fiabane,1,2 Marcella Ottonello,1,3 Valeria Zavan,4 Caterina Pistarini,1 Ines Giorgi5 1Department of Physical and Rehabilitation Medicine, ICS Maugeri Spa SB, Institute of Genoa Nervi, Genoa, 2Department of Brain and Behavioral Sciences, University of Pavia, Pavia, 3Department of Medicine, PhD Program in Advance Sciences and Technologies in Rehabilitation Medicine and Sport, Università di Tor Vergata, Rome, 4Alcohol Unit, Addiction Department, Alessandria, 5Psychology Unit, I...

Ingreso y permanencia en estudiantes de Licenciatura en Nutrición de la Facultad de Bioquímica y Ciencias Biológicas de la Universidad Nacional del Litoral. Estudio de la cohorte 2011

OpenAIRE

Dezar, Gimena Valeria Alfonsina

2016-01-01

Fil: Dezar, Gimena Valeria Alfonsina. Universidad Nacional del Litoral. Facultad de Humanidades y Ciencias; Argentina. La problemática del ingreso y la permanencia ocupa un lugar central en la Universidad Nacional del Litoral (UNL). Uno de los aspectos que se plantea es la necesidad de desarrollar acciones diversificadas y coordinadas que atiendan la heterogeneidad del alumnado que ingresa a la Universidad. La Facultad de Bioquímica y Ciencias Biológicas (FBCB) con su conjunto de carreras,...

A brief history of the evolution of surveying and its role in today´s world | Uma breve história da evolução do levantamento e seu papel no mundo de hoje

Directory of Open Access Journals (Sweden)

Rafael Silva Anjos

2016-06-01

The land surveying appeared millennia ago as a measurement technique for large human constructions. Before all its historical process that science has gone through phases of improvement that has become quite popular nowadays. Since the first measurement instruments as the Egyptian Groma to the use of theodolites and total stations integrated with all kinds of instruments of spatial data acquisition (GNSS receivers, aerial photographs, multispectral satellites the surveying methods now form the basis for various types of research. Quite confused with other sciences, such as Geodesy, Topography makes a more limited planialtimetric survey. That is why their applications are given in areas such as civil engineering, architecture, agronomy to architecture. If we know the differentiation of these key concepts related to topography we can to understand the applicability of this science, helping researchers in various fields. It is in this context, that the present paper aims to address the main concepts related to topography and the main activities human using this technique, making a historical approach since the beginning of its use to the instruments most widely used in the survey.

PREMISA: Un PRoceso para la Evolución y ModernIzación de SistemAs. Aplicación a Red.es

OpenAIRE

Moratalla Collado, Jorge

2016-01-01

Tesis Doctoral leída en la Universidad Rey Juan Carlos de Madrid en 2012. Directora de la Tesis: María Valeria de Castro Co-director de Tesis: Marcos López Sanz En los últimos años, la necesidad de modernización de los sistemas heredados se ha convertido en uno de los principales problemas a los que se enfrentan las organizaciones, ya sea para incorporar nuevas funcionalidades o para adaptarse a diferentes plataformas tecnológicas. En ese sentido, cuestiones como la reducció...

Euroopa Liiduga liitumise tähendus venekeelse elanikkonna identiteedile / Valeria Jakobson

Index Scriptorium Estoniae

Jakobson, Valeria, 1972-

2004-01-01

Ilmunud ka: Media reflections on integration concept: monitoring of Estonian media 1999-2003. - Tartu, 2004, lk. 47-62; Raznoobrazije podhodov k integratsii v SMI: integratsionnõi mediamonitoring 1999-2003. - Tartu, 2004, lk. 51-65. Autori väitel tekib lojaalsus üksnes nende konkreetsete subjektide suhtes, mis loovad soodsamaid tingimusi eneseteostamiseks ja mis tunnistavad indiviidi/grupi õigust olla erinev ning suhtlevad indiviidi/grupiga kui partneriga. Tabelid

María Teresa Andruetto: «soy descendiente de italianos, soy mujer, soy latinoamericana, soy del interior, soy de provincia...»

OpenAIRE

Ansó, Valeria

2017-01-01

Entrevista realizada por Valeria Ansó María Teresa Andruetto es actualmente una de las escritoras argentinas más estudiadas en el ámbito académico italiano en relación a la literatura de migración y los estudios de género. En esta entrevista indagamos acerca de la relación de la autora con la literatura italiana y con su ascendencia de inmigrantes, así como sus ideas sobre la escritura femenina y su experiencia como escritora proveniente del interior del país que, sin embargo, ingresó al circ...

Perfil clínico-epidemiológico e ocorrência de infecção pelo Citomegalovírus em pacientes com doença inflamatória intestinal em hospital de referência no Nordeste do Brasil

OpenAIRE

MARTINELLI, Valeria Ferreira

2013-01-01

MARTINELLI, Valeria Ferreira. Perfil clínico-epidemiológico e ocorrência de infecção pelo citomegalovírus em pacientes com doença inflamatória intestinal em hospital de referência no Nordeste do Brasil. Recife, 2013. 126 f. Dissertação (mestrado) - UFPE, Centro de Ciências da Saúde, Programa de Pós-graduação em Ciências da Saúde , 2013 A Doença Inflamatória Intestinal (DII) compreende a Retocolite Ulcerativa e a Doença de Crohn. Portadores de DII são considerados de risco para reativaçã...

Guía para la localización de fuentes relativas al País Vasco en el Archivo Secreto Vaticano [RESEÑA

OpenAIRE

Ferrer-del-Río, E. (Estefanía)

2015-01-01

Reseña de "Valeria BEOLCHINI – Marta PAVÓN RAMÍREZ, Guía para la localización de fuentes relativas al País Vasco en el Archivo Secreto Vaticano. Documentación medieval. Díaz de Durana, José Ramón; Jular Pérez-Alfaro, Cristina (coords.), Universidad del País Vasco, Bilbao 2014, 91 pp." y "Marta PAVÓN RAMÍREZ, Guía para la localización de fuentes relativas al País Vasco en el Archivo Secreto Vaticano. Documentación de época moderna (1458-1830) Porres Marijuán, Rosario et al. (coords.), Unive...

Regard critique sur une période sans but : Antigone de Valeria Parrella

Directory of Open Access Journals (Sweden)

Patrizia Farinelli

2015-04-01

Full Text Available Seul un petit nombre de mythes classiques ont retenu autant l'attention que celui d'Antigone. Pendant l'Idéalisme et tout le siècle suivant, l'intérêt pour la version de Sophocle de ce mythe – et plus généralement pour la tragédie classique – s'explique, selon George Steiner, par une conception tragique de la condition humaine (Steiner, 1984, 2. Quelles seraient alors les raisons de cet intérêt à une époque plus récente, sujette à une perte du sens du tragique ? Car, même durant les soixante dernières années, l'histoire de la fille d'Œdipe a été revisitée avec une fréquence surprenante. Selon Hannes Koch (1992, 23, auteur d'une étude sur la réception de la figure d'Antigone dans la littérature allemande du XXe siècle, la mise en valeur de ce personnage est liée à un moment où les droits de l'homme sont ignorés par le pouvoir. Et ce phénomène de mise en valeur implique toujours une crispation dans la sphère politique ayant pour conséquence de souligner justement l'importance politique du geste d'Antigone.

Normal Families of A Kind of Holomorphic Functions Concerning Derivatives%涉及导数的一类全纯函数的正规族

Institute of Scientific and Technical Information of China (English)

姜云波

2011-01-01

主要使用Zalcman引理来研究全纯函数的正规族,得到了如下的结论:令F为|z|＜1内的一族全纯函数,n是一个正整数,a,b是两个复数且满足a≠0,∞,b≠∞.若F满足:Ⅰ)(A)f∈F,如f有零点,则f的零点重级大于等于3;和Ⅱ)当n≥4时,对F的每一对函数G和日,G″-aGn1与H″-aHn分担b.则F在|z|＜1内正规.%In this paper,we mainly use Zalcman lemna to investigate normal families of holomorphic functions, and gets the following results: let (F) e a family of holomorphic functions in |z| ＜ 1,n is a positive integer, a, b are two complex numbers and satisfies α≠0, ∞, b≠ ∞, If (F) satisfies: (Ⅰ) for （V）f ∈(F),if f has zeros, then the multiplicity of zeros of f is greater than or equal to 3; and (Ⅱ)when n ≥ 4,for every pair of functions G and H belong to (F)， G11 - aGn and H11 - aHn share b. then (F) is normal in |z| ＜ 1.

Technical training - Places available

CERN Document Server

2012-01-01

If you would like more information on a course, or for any other inquiry/suggestions, please contact Technical.Training@cern.ch Valeria Perez Reale, Learning Specialist, Technical Programme Coordinator (Tel.: 62424) Eva Stern and Elise Romero, Technical Training Administration (Tel.: 74924)   Electronics design Next Session Duration Language Availability Certified LabVIEW Associate Developer (CLAD) 06-Dec-12 to 06-Dec-12 1 hour English One more place available Compatibilité électromagnetique (CEM): Applications 23-Nov-12 to 23-Nov-12 3.5 hours English 3 places available Compatibilité électromagnétique (CEM): Introduction 23-Nov-12 to 23-Nov-12 3 hours English 43 places available Effets des Radiations sur les composants et systèmes électroniques 11-Dec-12 to 12-Dec-12 1 day 4 hours French 9 places available LabVIEW for beginners ...

Risperidone in the treatment of behavioral disorders associated with autism in children and adolescents

Directory of Open Access Journals (Sweden)

Roberto Canitano

2008-09-01

Full Text Available Roberto Canitano, Valeria ScandurraDivision of Child Neuropsychiatry, University Hospital of Siena, Siena, ItalyAbstract: This is a review of the clinical trials investigating the efficacy and safety of risperidone in the treatment of children with autistic spectrum disorders (ASD. The main clinical characteristics are impairment in social skills, communication difficulties, repetitive movements and behaviors, including stereotypies. Pharmacotherapy is mainly directed at the so-called target symptoms, ie, behavioral disorders and the various kinds of repetitions associated with ASD. According to the available data, risperidone seems to be moderately efficacious and safe for treating behavioral disorders. 4 double blind controlled trial. 3 reanalysis studies, and 12 open studies have documented the role of risperidone in children with ASD. Controlled studies have been thoroughly considered in this review.Keywords: autism, pervasive developmental disorders, risperidone

Waves from the Sun: to the 100th anniversary of V.A. Troitskaya's birth

Science.gov (United States)

Guglielmi, Anatol; Potapov, Alexander

2017-09-01

It has been one hundred years since the birth of the outstanding scientist Professor V.A. Troitskaya. Her remarkable achievements in solar-terrestrial physics are widely known. For many years, Valeria A. Troitskaya was the President of the International Association of Geomagnetism and Aeronomy. This article deals with only one aspect of the multifaceted creative activity of V.A. Troitskaya. It relates to the problem of sources of ultra-low frequency (ULF) electromagnetic oscillations and waves outside Earth’s magnetosphere. We were fortunate to work under the leadership of V.A. Troitskaya on this problem. In this paper, we briefly describe the history from the emergence of the idea of the extramagnetospheric origin of dayside permanent ULF oscillations in the late 1960s to the modern quest made by ground and satellite means for ULF waves excited by solar surface oscillations propagating in the interplanetary medium and reaching Earth.

Eesti keelenõuded kohati Venemaa omadest leebemad / Jaanus Piirsalu ; kommenteerinud Mart Rannut, Mart Nutt, Valeria Jakobson

Index Scriptorium Estoniae

Piirsalu, Jaanus, 1973-

2011-01-01

Eesti välisministeerium tüdines Moskva pidevast kriitikast keelepoliitika karmuse kohta ning lasi teha Eesti ja Venemaa keelenõuete võrdleva analüüsi, mille tulemuste järgi on Venemaa nõuded kohati isegi karmimad

Triumfalnoje vozvrashtshenije 60-h / Airika Soome, Jaanika Sootna, Merike Pääro...[jt.] ; interv. Valeria Aru

Index Scriptorium Estoniae

2007-01-01

Eesti tuntuimate kaubamärkide PTA, Monton, Bastion, Ivo Nikkolo ja Mosaic moekunstnike nägemused moest kevad-suveks 2007. PTA - Airika Soome, Monton - Jaanika Sootna, Bastion - Merike Pääro, Ivo Nikkolo - Eve Hanson ja Mosaic - Evelin Lill

Corporate taxes and internal borrowing within multinational firms / Peter Egger, Christian Keuschnigg, Valeria Merlo, Georg Wamser

Index Scriptorium Estoniae

2014-01-01

Artiklis esitatakse sisemise kapitalituruga rahvusvaheliste ettevõtete teoreetilist mudeli, käsitledes selliseid aspekte nagu kohalik vs. välismaised karakteristikud (kasumi maksumäärad, puudused institutsionaalses kvaliteedis, finantssektori nõrkus jt.), aluseks Saksamaa rahvusvahelised ettevõtted eri riikides (sh. Eesti).

Controvérsias metodológicas em psicologia social: revendo posturas no campo

Directory of Open Access Journals (Sweden)

Maria de Fatima Aranha de Queiroz e Melo

2013-01-01

Full Text Available Este artigo se propõe a apresentar o fragmento de um estudo realizado em torno da brincadeira de pipas - atividade lúdica tradicional que se mantém em nossos dias entre crianças e jovens -, mobilizando controvérsias metodológicas eliciadas em campo sobre a postura do pesquisador, sobre o papel dos atores enquanto coautores de nossas histórias e sobre as implicações éticas de nossas escolhas na maneira de abordar nossos pesquisados. Utilizamos como fundamento teórico-metodológico a Teoria Ator-Rede, buscando exercitar uma prática de pesquisa apoiada na necessária polidez inerente à construção do conhecimento, ideia defendida por Despret e por Latour. Para esses autores, uma pesquisa só valeria a pena se, ao seu final, as partes envolvidas tivessem se diferenciado em relação a como eram em seu início.

Factors influencing choice of chemotherapy in metastatic colorectal cancer (mCRC

Directory of Open Access Journals (Sweden)

Rossi L

2013-11-01

Full Text Available Luigi Rossi, Foteini Vakiarou, Federica Zoratto, Loredana Bianchi, Anselmo Papa, Enrico Basso, Monica Verrico, Giuseppe Lo Russo, Salvatore Evangelista, Guilia Rinaldi, Francesca Perrone-Congedi, Gian Paolo Spinelli, Valeria Stati, Davide Caruso, Alessandra Prete, Silverio TomaoDepartment of Medico-Surgical Sciences and Biotechnologies, "Sapienza" University of Rome, Rome, Italy; Oncology Unit, ICOT, Latina, ItalyAbstract: Management of metastatic colorectal cancer requires a multimodal approach and must be performed by an experienced, multidisciplinary expert team. The optimal choice of the individual treatment modality, according to disease localization and extent, tumor biology, and patient clinical characteristics, will be one that can maintain quality of life and long-term survival, and even cure selected patients. This review is an overview of the different therapeutic approaches available in metastatic colorectal cancer, for the purpose of defining personalized therapeutic algorithms according to tumor biology and patient clinical features.Keywords: metastatic colorectal cancer, patient clinical features, tumor biology, multidisciplinary approach

The city of Arcávica and the Foundation of the Servitanus Monastery

Directory of Open Access Journals (Sweden)

Rafael Barroso Cabrera

2018-02-01

Full Text Available During the Visigothic period, the city of Arcavica was one of the three bishoprics placed in the present province of Cuenca, together with those of Segobriga and Valeria. With the exception of the signatures of Arcavica's prelates on Council minutes there is no direct mention of the city in the sources available. Even so, the importance of its archaeological site is reflected in the numerous remains found on the hill where the Roman-Celtiberian city of Ercavica used to lay. However important the city itself may be, archaeological research in this area is mainly focused on the problem of locating the Servitanus Monastery founded by the North-African abbot Donatus and his seventy monks. Its location in Arcavica, as the authors of the present article defend, is essential to interpret the remains found in this site and to understand a significant part of Spain's history that takes place during the crucial years of Leovigild's and Recared's reigns.

Technical training: places available

CERN Document Server

2013-01-01

If you would like more information on a course, or for any other inquiry/suggestions, please contact Technical.Training@cern.ch Valeria Perez Reale, Learning Specialist, Technical Programme Coordinator (Tel.: 62424) Eva Stern and Elise Romero, Technical Training Administration (Tel.: 74924)   Electronics design Next Session Duration Language Introduction to VHDL 21-Feb-13 to 22-Feb-13 2 days English Mechanical design Next Session Duration Language ANSYS - Introduction à ANSYS Mechanical APDL 04-Feb-13 to 07-Feb-13 4 days English Applications de la cotation fonctionnelle et du langage ISO 06-Feb-13 to 08-Feb-13 2 days 4 hours French CATIA V5 – Surfacique 14-Jan-13 to 15-Jan-13 2 days French Office software Next Session Duration Language ACCESS 2010 - niveau 2 : ECDL 06-Feb-13 to 07-Feb-13 2 days French Dreamweaver CS3 - Niveau 1 14-Jan-13 to 15-Jan-13 2 d...

Waves from the Sun: to the 100th anniversary of V.A. Troitskaya’s birth

Directory of Open Access Journals (Sweden)

Guglielmi A.V.

2017-09-01

Full Text Available It has been one hundred years since the birth of the outstanding scientist Professor V.A. Troitskaya. Her remarkable achievements in solar-terrestrial physics are widely known. For many years, Valeria A. Troitskaya was the President of the International Association of Geomagnetism and Aeronomy. This article deals with only one aspect of the multifaceted creative activity of V.A. Troitskaya. It relates to the problem of sources of ultra-low frequency (ULF electromagnetic oscillations and waves outside Earth’s magnetosphere. We were fortunate to work under the leadership of V.A. Troitskaya on this problem. In this paper, we briefly describe the history from the emergence of the idea of the extramagnetospheric origin of dayside permanent ULF oscillations in the late 1960s to the modern quest made by ground and satellite means for ULF waves excited by solar surface oscillations propagating in the interplanetary medium and reaching Earth.

Technical training - Places available

CERN Multimedia

2012-01-01

If you would like more information on a course, or for any other inquiry/suggestions, please contact Technical.Training@cern.ch Valeria Perez Reale, Learning Specialist, Technical Programme Coordinator (Tel.: 62424) Eva Stern and Elise Romero, Technical Training Administration (Tel.: 74924) HR Department Electronic Design Next Session Duration Language Availability Comprehensive VHDL for FPGA Design 08-Oct-12 to 12-Oct-12 5 days English 4 places Electrostatique / Protection ESD 28-Sep-12 to 28-Sep-12 3 hours French 25 places Impacts de la suppression du plomb (RoHS) en électronique 26-Oct-12 to 26-Oct-12 8 hours French 14 places Introduction to VHDL 10-Oct-12 to 11-Oct-12 2 days English 9 places LabVIEW Real Time and FPGA 13-Nov-12 to 16-Nov-12 5 days French 5 places LabVIEW for Experts 24-Sep-12 to 28-Sep-12 5 days English 6 places LabVIEW for beginners 15-Oct-12 to 17-...

Technical training - places available

CERN Multimedia

2012-01-01

If you would like more information on a course, or for any other inquiry/suggestions, please contact Technical.Training@cern.ch Valeria Perez Reale, Learning Specialist, Technical Programme Coordinator (Tel.: 62424) Eva Stern and Elise Romero, Technical Training Administration (Tel.: 74924) HR Department »Electronics design Next Session Duration Language Availability Comprehensive VHDL for FPGA Design 08-Oct-12 to 12-Oct-12 5 days English 3 places available Foundations of Electromagnetism and Magnet Design (EMAG) 14-Nov-12 to 27-Nov-12 6 days English 20 places available Impacts de la suppression du plomb (RoHS) en électronique 26-Oct-12 to 26-Oct-12 8 hours French 15 places available Introduction to VHDL 10-Oct-12 to 11-Oct-12 2 days English 7 places available LabVIEW Real Time and FPGA 13-Nov-12 to 16-Nov-12 5 days French 5 places available »Mechanical design Next Se...

La educación por los sentidos: Memoria y formación en Contra paraíso y Tranvía a la Malvarrosa de Manuel Vicent

Directory of Open Access Journals (Sweden)

Gerardo J. Balverde

2008-11-01

Full Text Available Up to now Manuel Vicent has published four books that have been regarded as autobiographic: Contra paraíso (1993, Tranvía a la malvarrosa(1994, Jardín de Villa Valeria (1996 and Verás el cielo abierto (2006.The first two books refer to childhood and youth and construct, read together, an autofiction and at the same time a Bildungsroman that, upon the acknowledged background of Franco dictatorship, tell the ups and downs and discoveries of the protagonist who grows up in a world full of contrasts. The literary configuration of childhood and adolescence is being achieved in terms of exploration of the world, and the way of attaining it is basically by means of senses. The aim of this paper is to go deep inside the dialogue between the autofiction and the apprenticeship novel, framed by the repressive Spain between the decades oh the thirties and sixties of twentieth century

Léxico e Ideología en el Mortibus Persecutorum de Lactancio: El caso de Valeria y Prisca

Directory of Open Access Journals (Sweden)

Felipe GONZÁLEZ VEGA

2009-11-01

Full Text Available El texto literario es, al tiemipo que un producto derivado de la estética dominante en su época, generador de un contexto de amplia resonancia en los distintos grupos sociales. Ello se registra como un fenómeno de boomerang, toda vez que la sociedad brinda al escritor la posibilidad en bruto de un acto de creación literaria, para posteriormente, y tras conformarlo de manera artística, hacerlo repercutir sobre sus usuarios.

Representations of the past in the Estonian Russian-language press: „own” or diaspora memory / Triin Vihalemm, Valeria Jakobson

Index Scriptorium Estoniae

Vihalemm, Triin, 1968-

2011-01-01

Artiklis käsitletakse kollektiivse identiteedi küsimust venekeelsete elanike seas Eestis, aluseks 2009. aastal kohalikus venekeelses ajakirjanduses ilmunud ajaloosündmusi käsitlevad tekstid. Võrdlusena tuuakse andmed eestikeelsest ajakirjandusest. Tabelid

Gemcitabine-loaded liposomes: rationale, potentialities and future perspectives

Directory of Open Access Journals (Sweden)

Federico C

2012-11-01

Full Text Available Cinzia Federico, Valeria M Morittu, Domenico Britti, Elena Trapasso, Donato CoscoDepartment of Health Sciences, Building of BioSciences, University “Magna Græcia” of Catanzaro, Campus Universitario “S Venuta”, Germaneto, ItalyAbstract: This review describes the strategies used in recent years to improve the biopharmaceutical properties of gemcitabine, a nucleoside analog deoxycytidine antimetabolite characterized by activity against many kinds of tumors, by means of liposomal devices. The main limitation of using this active compound is the rapid inactivation of deoxycytidine deaminase following administration in vivo. Consequently, different strategies based on its encapsulation/complexation in innovative vesicular colloidal carriers have been investigated, with interesting results in terms of increased pharmacological activity, plasma half-life, and tumor localization, in addition to decreased side effects. This review focuses on the specific approaches used, based on the encapsulation of gemcitabine in liposomes, with particular attention to the results obtained during the last 5 years. These approaches represent a valid starting point in the attempt to obtain a novel, commercializable drug formulation as already achieved for liposomal doxorubicin (Doxil®, Caelyx®.Keywords: gemcitabine, liposomes, multidrug, poly(ethylene glycol, tumors

Literary awards 2000

Index Scriptorium Estoniae

2001-01-01

Riigi kultuuripreemia: Andres Ehin (koondkogu "Alateadvus on alatasa purjus" eest); Eesti Kultuurkapitali aastapreemia: Jaan Kaplinski (luule koondkogu "Kirjutatud", romaanid "Silm" ja "Hektor" ning esseeraamat "Kevad kahel rannikul ehk Tundeline teekond Ameerikasse"; Kirjanduse sihtkapitali aastapreemiad: Udo Uibo ajakirja Looming uuendamise eest ning Märt Väljataga raamatusarja "Avatud Eesti raamat" algatamise ja suunamise eest; Eesti kirjanduse aastapreemia: Proosa - Andrus Kivirähk "Rehepapp". Luule - Hando Runnel "Mõistatused". Näitekirjandus - Mart Kivastik "Näidendid". Esseistika - Maie Kalda "Mis mees ta on?". Lastekirjandus - Valeria Ränik "Ülejõel, Kassilaiu pealinnas". Tõlge eesti keelde - Krista Kaer (tõlked inglise keelest: Doris Lessingi "Kuldne märkmeraamat" ja J. K. Rowling'i Harry Potteri lood). Tõlge eesti keelest - Mai Bereczki (ungarikeelse eesti luule antoloogia "Kellade hellus" I-II koostamine); Romaanivõistluse võitjad: I koht - Aarne Ruben ""Volta" annab kaeblikku vilet"; II koht - Leo Kunnas "Sõdurjumala teener"; III koht - Maimu Veske "Continental" ja Lehte Hainsalu "Kellakuuljad"; Ulmekirjanduse eripreemia Varrakult - Indrek Hargla "Baiita needus"; B. Alveri kirjandusauhind: Jürgen Rooste (esikkogu "Sonetid"); Virumaa kirjanduspreemia: Andrus Kivirähk (romaan "Rehepapp"); F. Tuglase novelliauhind: Mati Unt ("Nouvelle") ja Tarmo Teder ("Kohtumine")

Üleminek riigikeelsele gümnaasiumiõppele : vilistlaste seisukohtade Q-metodoloogiline diskursusanalüüs / Anu Masso, Katrin Kello, Valeria Jakobson

Index Scriptorium Estoniae

Masso, Anu, 1977-

2013-01-01

Keskendutakse diskursustele, mis on seotud riigikeelsele gümnaasiumiõppele üleminekuga senistes vene õppekeelega koolides. Uuring põhineb Tallinnas, Tartus, Ida-Virumaal ja Lätis läbi viidud Q-metodoloogilistel intervjuudel

Mario Fresa (Salerno, 1973

Directory of Open Access Journals (Sweden)

Paolino Nappi

2017-01-01

Full Text Available Mario Fresa cursa estudios clásicos y musicales y se licencia en Literatura Italiana. Es traductor de Catulo, Marcial, Bernardo de Claraval, Baudelaire, Musset, Desnos, Apollinaire, Frénaud, Cendrars, Char, Duprey y Queneau, además de autor de libros de ensayo, poesía y crítica literaria. Comienza su carrera como poeta en 1999 presentado por Maurizio Cucchi en Specchio, el suplemento semanal del periódico La Stampa. Algunos de sus textos han formado parte de la antología Nuovissima poesia italiana (Mondadori, 2004 y han aparecido en las principales revistas culturales italianas como Caffè Michelangiolo, Paragone y Nuovi Argomenti. De 2002 es la colección de poemas Liaison (Premio Giusti Opera Prima, con prefacio de Maurizio Cucchi, a la que han seguido, entre otros títulos, Costellazione urbana (Mondadori, col. Almanacco dello Specchio, 2008, el poema Alluminio (con prefacio de Mario Santagostini, Lietocolle, 2008, Uno stupore quieto (edizioni Stampa, a cargo de M. Cucchi, 2012, mención especial del Premio Internacional de Literatura Ciudad de Como o La tortura per mezzo delle rose (aparecido en el volumen 14 de la revista Smerilliana y con un ensayo de Valeria Di Felice. Firma la columna Sguardi en la revista de poesía Gradiva. International Journal of Italian Poetry, en la que además es redactor.

ALEXA VISARION AND THE CARAGIALIAN TEXTS - ESSENCE AND EXPRESSIVENESS

Directory of Open Access Journals (Sweden)

BĂLĂIŢĂ VASILICA

2015-09-01

Full Text Available Ion Luca Caragiale is a national playwright, and is considered a symbol of Romanian society, and more than 100 years have passed since apparently we have not separated psychologically and behaviourally from the template (pattern in which loan Luca Caragiale had set the Romanian society. We believe it’s even worse that students at the Faculty of Theater, in the ab­sence of anthropological study, play dramatic texts literally, which increases the risk to stereotype Caragiale’s opera in school. In this article we intend to present Alexa Visarion’s[1] films, based on Ion Luca Caragiale’s short stories, as well as the play Dale Carnavalului (Of the Carnival directed by him, as a guest professor, at the National Theatre Art Institute from Reykja-vic, Island (1989. The movies we refer to were the result of some performances played almost with the same distribution for a decade: Năpasta (The Scourage, after the short story with the same name, a movie directed in 1985, starring Dorina Lazar, Florin Zamfirescu and Dorel Visan; Inainte de tacere (Before silence, directed in 1978, after the story In vreme de razboi (in time of war novel starring Valeria Seciu and Liviu Rozorea. Our demarche aims at highlighting the universality of Ioan Luca Caragiale by essentialization and expressivity.

Quadrillages labyrinthiques: l’échiquier Caillois. Centenaire de la naissance de Roger Caillois, sous la direction de Valeria Emi Sgueglia et André-Alain Morello

OpenAIRE

Gardini, Michela

2016-01-01

Il volume si presenta come un omaggio per il centenario della nascita di Roger Caillois (1913) e raccoglie saggi di autori diversi in onore del celebre critico. Come suggerito dal titolo, l’opera di Caillois a cui tutti gli autori fanno riferimento è Cases d’un échiquier del 1970, un’opera mosaico presa come simbolo della molteplicità della ricerca epistemologica di Caillois. In apertura, dopo l’articolo introduttivo di André-Alain Morello (Une des récompenses de la rêverie, pp. 9-13), Enzo ...

An integrated study on antimicrobial activity and ecotoxicity of quantum dots and quantum dots coated with the antimicrobial peptide indolicidin

Directory of Open Access Journals (Sweden)

Galdiero E

2016-08-01

Full Text Available Emilia Galdiero,1 Antonietta Siciliano,1 Valeria Maselli,1 Renato Gesuele,1 Marco Guida,1 Domenico Fulgione,1 Stefania Galdiero,2 Lucia Lombardi,3 Annarita Falanga2 1Department of Biology, University of Naples “Federico II”, Naples, Italy; 2Department of Pharmacy and Cirpeb, University of Naples “Federico II”, Naples, Italy; 3Department of Experimental Medicine, Second University of Naples, Naples, Italy Abstract: This study attempts to evaluate the antimicrobial activity and the ecotoxicity of quantum dots (QDs alone and coated with indolicidin. To meet this objective, we tested the level of antimicrobial activity on Gram-positive and Gram-negative bacteria, and we designed an ecotoxicological battery of test systems and indicators able to detect different effects using a variety of end points. The antibacterial activity was analyzed against Staphylococcus aureus (ATCC 6538, Pseudomonas aeruginosa (ATCC 1025, Escherichia coli (ATCC 11229, and Klebsiella pneumoniae (ATCC 10031, and the results showed an improved germicidal action of QDs-Ind. Toxicity studies on Daphnia magna indicated a decrease in toxicity for QDs-Ind compared to QDs alone, lack of bioluminescence inhibition on Vibrio fisheri, and no mutations in Salmonella typhimurium TA 100. The comet assay and oxidative stress experiments performed on D. magna showed a genotoxic and an oxidative damage with a dose–response trend. Indolicidin retained its activity when bound to QDs. We observed an enhanced activity for QDs-Ind. The presence of indolicidin on the surface of QDs was able to decrease its QDs toxicity. Keywords: peptide, quantum dots, ecotoxicity, antimicrobial activity, oxidative stress, genotoxicity

Pidiendo la defensa de un título de doctor 16 años después

Directory of Open Access Journals (Sweden)

AIBR. Consejo de Redacción

2007-05-01

Full Text Available Este texto presenta los hechos denunciados el pasado día 6 de abril de 2007 por el Sr. David E. Aliaga Rossel, investigador universitario chileno residente en Canadá, con el fin de solicitar el apoyo de esta publicación en el caso que actualmente lleva contra la Universidad de Calabria, Italia. Diversas asociaciones internacionales, así como intelectuales de reconocido prestigio (Noam Chomsky, James L. Peacock, Ariel Dorfman o Mario Medina Valeria entre otros, han manifestado públicamente su defensa ante las solicitudes del investigador chileno. Según las fuentes que hemos podido consultar y a falta de conseguir la versión de una de las partes, David Aliaga se inscribió en el programa de doctorado en Etnoantropología, impartido por la Universidad de Calabria, en el año 1987. Una vez realizados los estudios doctorales, presentó su tesis ante la universidad, contando con el visto bueno para su evaluación. El día 25 de julio de 1991 fue la fecha designada por la universidad para cumplir con el examen doctoral ante la comisión examinadora. Ese día, la comisión examinadora no se presentó en pleno y además le negó el título de doctor al examinado sin permitirle la defensa. De acuerdo con el Sr. Aliaga, esta actitud fue una revancha ante las denuncias que él había realizado anteriormente sobre las serias irregularidades existentes en dicha Universidad.

Daphnia magna and Xenopus laevis as in vivo models to probe toxicity and uptake of quantum dots functionalized with gH625

Directory of Open Access Journals (Sweden)

Galdiero E

2017-04-01

Full Text Available Emilia Galdiero,1 Annarita Falanga,2 Antonietta Siciliano,1 Valeria Maselli,1 Marco Guida,1 Rosa Carotenuto,1 Margherita Tussellino,1 Lucia Lombardi,3 Giovanna Benvenuto,4 Stefania Galdiero2 1Department of Biology, 2Department of Pharmacy and CiRPEB, University of Naples Federico II, 3Department of Experimental Medicine, Second University of Naples, 4Stazione Zoologica Anton Dohrn, Villa Comunale, Napoli, Italy Abstract: The use of quantum dots (QDs for nanomedicine is hampered by their potential toxicologic effects and difficulties with delivery into the cell interior. We accomplished an in vivo study exploiting Daphnia magna and Xenopus laevis to evaluate both toxicity and uptake of QDs coated with the membranotropic peptide gH625 derived from the glycoprotein H of herpes simplex virus and widely used for drug delivery studies. We evaluated and compared the effects of QDs and gH625-QDs on the survival, uptake, induction of several responsive pathways and genotoxicity in D. magna, and we found that QDs coating plays a key role. Moreover, studies on X. laevis embryos allowed to better understand their cell/tissue localization and delivery efficacy. X. laevis embryos raised in Frog Embryo Teratogenesis Assay-Xenopus containing QDs or gH625-QDs showed that both nanoparticles localized in the gills, lung and intestine, but they showed different distributions, indicating that the uptake of gH625-QDs was enhanced; the functionalized QDs had a significantly lower toxic effect on embryos’ survival and phenotypes. We observed that D. magna and X. laevis are useful in vivo models for toxicity and drug delivery studies. Keywords: membranotropic peptide, delivery, blood–brain barrier, nanoparticles, genotoxicity

Nanostructured systems containing babassu (Orbignya speciosa oil as a potential alternative therapy for benign prostatic hyperplasia

Directory of Open Access Journals (Sweden)

de Sousa VP

2013-08-01

Full Text Available Valeria Pereira de Sousa,1 Joanne Crean,2 Vinícius Raphael de Almeida Borges,1 Carlos Rangel Rodrigues,1 Lidia Tajber,2 Fabio Boylan,2 Lucio Mendes Cabral1 1Department of Pharmaceutics, Faculty of Pharmacy, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil; 2School of Pharmacy and Pharmaceutical Sciences and Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland Abstract: The oil of babassu tree nuts (Orbignya speciosa is a potential alternative for treatment and prophylaxis of benign prostatic hyperplasia. Improved results can be obtained by drug vectorization to the hyperplastic tissue. The main objective of this work was the preparation and characterization of poly(lactic-co-glycolic acid (PLGA nanoparticle and clay nanosystems containing babassu oil (BBS. BBS was extracted from the kernels of babassu tree nuts and characterized by gas chromatography-mass spectrometry as well as 1H and 13C nuclear magnetic resonance. BBS-clay nanosystems were obtained by adding polyvinylpyrrolidone, Viscogel B8®, and BBS at a 2:1:1 mass ratio and characterized by X-ray diffraction, thermogravimetric analysis, infrared spectroscopy, and laser diffraction. The PLGA-BBS nanoparticles were prepared by the precipitation-solvent evaporation method. Mean diameter, polydispersity, zeta potential, and scanning electron microscopic images of the nanosystems were analyzed. Thermogravimetric analysis showed successful formation of the nanocomposite. PLGA nanoparticles containing BBS were obtained, with a suitable size that was confirmed by scanning electron microscopy. Both nanostructured systems showed active incorporation yields exceeding 90%. The two systems obtained represent a new and potentially efficient therapy for benign prostatic hyperplasia. Keywords: babassu oil, nanocomposite, poly(lactic-co-glycolic acid, nanoparticles, benign prostatic hyperplasia, treatment, nanotechnology

Development and characterization of a new oral dapsone nanoemulsion system: permeability and in silico bioavailability studies

Directory of Open Access Journals (Sweden)

Monteiro LM

2012-09-01

Full Text Available Lidiane M Monteiro,1 Viviane F Lione,1 Flavia A do Carmo,1 Lilian H do Amaral,1 Julianna H da Silva,2 Luiz E Nasciutti,2 Carlos R Rodrigues,1 Helena C Castro,3 Valeria P de Sousa,1 Lucio M Cabral11Faculdade de Farmácia, Universidade Federal do Rio de Janeiro, 2Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, 3Instituto de Biologia, Universidade Federal Fluminense, Niterói, Rio de Janeiro, BrasilBackground: Dapsone is described as being active against Mycobacterium leprae, hence its role in the treatment of leprosy and related pathologies. Despite its therapeutic potential, the low solubility of dapsone in water results in low bioavailability and high microbial resistance. Nanoemulsions are pharmaceutical delivery systems derived from micellar solutions with a good capacity for improving absorption. The aim of this work was to develop and compare the permeability of a series of dapsone nanoemulsions in Caco-2 cell culture against that of effective permeability in the human body simulated using GastroplusTM software.Methods and results: The release profiles of the dapsone nanoemulsions using different combinations of surfactants and cosolvent showed a higher dissolution rate in simulated gastric and enteric fluid than did the dispersed dapsone powder. The drug release kinetics were consistent with a Higuchi model.Conclusion: This comparison of dapsone permeability in Caco-2 cells with effective permeability in the human body simulated by Gastroplus showed a good correlation and indicates potential improvement in the biodisponibility of dapsone using this new system.Keywords: dapsone, nanoemulsions, antibacterial, permeability, Caco-2 cell, GastroplusTM

Controvérsias metodológicas em psicologia social: revendo posturas no campo Methodological controversies in social psychology: reviewing postures in the field

Directory of Open Access Journals (Sweden)

Maria de Fatima Aranha de Queiroz e Melo

2013-01-01

Full Text Available Este artigo se propõe a apresentar o fragmento de um estudo realizado em torno da brincadeira de pipas - atividade lúdica tradicional que se mantém em nossos dias entre crianças e jovens -, mobilizando controvérsias metodológicas eliciadas em campo sobre a postura do pesquisador, sobre o papel dos atores enquanto coautores de nossas histórias e sobre as implicações éticas de nossas escolhas na maneira de abordar nossos pesquisados. Utilizamos como fundamento teórico-metodológico a Teoria Ator-Rede, buscando exercitar uma prática de pesquisa apoiada na necessária polidez inerente à construção do conhecimento, ideia defendida por Despret e por Latour. Para esses autores, uma pesquisa só valeria a pena se, ao seu final, as partes envolvidas tivessem se diferenciado em relação a como eram em seu início.This paper intends to present a fragment of a study about the popular kite trick - traditional playful activity that survives in our days among children and young people - mobilizing methodological controversies found in research field and placing in check the position of researchers, the actors roles while co-authors of our histories and ethical implications of our choices in the way to approach our searched. We have used Actor-Network Theory as theoretician methodological bedding, searching to exercise one practice of research supported in a necessary and inherent courtesy to the construction of the knowledge, idea defended by Despret and Latour. For these authors, one research would be valid only if, at its end, the involved parts would have been differentiated in relation as they were in its beginning.

SERS investigations and electrical recording of neuronal networks with three-dimensional plasmonic nanoantennas (Conference Presentation)

Science.gov (United States)

De Angelis, Francesco

2017-06-01

SERS investigations and electrical recording of neuronal networks with three-dimensional plasmonic nanoantennas Michele Dipalo, Valeria Caprettini, Anbrea Barbaglia, Laura Lovato, Francesco De Angelis e-mail: francesco.deangelis@iit.it Istituto Italiano di Tecnologia, Via Morego 30, 16163, Genova Biological systems are analysed mainly by optical, chemical or electrical methods. Normally each of these techniques provides only partial information about the environment, while combined investigations could reveal new phenomena occurring in complex systems such as in-vitro neuronal networks. Aiming at the merging of optical and electrical investigations of biological samples, we introduced three-dimensional plasmonic nanoantennas on CMOS-based electrical sensors [1]. The overall device is then capable of enhanced Raman Analysis of cultured cells combined with electrical recording of neuronal activity. The Raman measurements show a much higher sensitivity when performed on the tip of the nanoantenna in respect to the flat substrate [2]; this effect is a combination of the high plasmonic field enhancement and of the tight adhesion of cells on the nanoantenna tip. Furthermore, when plasmonic opto-poration is exploited [3] the 3D nanoelectrodes are able to penetrate through the cell membrane thus accessing the intracellular environment. Our latest results (unpublished) show that the technique is completely non-invasive and solves many problems related to state-of-the-art intracellular recording approaches on large neuronal networks. This research received funding from ERC-IDEAS Program: "Neuro-Plasmonics" [Grant n. 616213]. References: [1] M. Dipalo, G. C. Messina, H. Amin, R. La Rocca, V. Shalabaeva, A. Simi, A. Maccione, P. Zilio, L. Berdondini, F. De Angelis, Nanoscale 2015, 7, 3703. [2] R. La Rocca, G. C. Messina, M. Dipalo, V. Shalabaeva, F. De Angelis, Small 2015, 11, 4632. [3] G. C. Messina et al., Spatially, Temporally, and Quantitatively Controlled Delivery of

Thrombophilic screening in retinal artery occlusion patients

Directory of Open Access Journals (Sweden)

Valeria Nagy

2008-10-01

Full Text Available Valeria Nagy1, Lili Takacs1, Zita Steiber1, György Pfliegler2, Andras Berta11Department of Ophthalmology, 2Division of Rare Diseases, University of Debrecen Medical and Health Science Center, Debrecen, HungaryBackground: Retinal artery occlusion (RAO is an ischemic vascular damage of the retina, which frequently leads to sudden, mostly irreversible loss of vision. In this study, blood thrombophilic factors as well as cardiovascular risk factors were investigated for their relevance to this pathology. Thrombophilic risk factors so far not evaluated were included in the study.Patients and methods: 28 RAO patients and 81 matched control subjects were examined. From blood samples, protein C, protein S, antithrombinopathy, and factor V (Leiden mutation (FV, factor II gene polymorphism, factor VIII C level, plasminogen activity, lipoprotein(a and fibrinogen levels, hyperhomocysteinemia and presence of anticardiolipin – antiphospholipid antibodies were investigated. Possibly relevant pathologies such as diabetes mellitus, hypertension, and ischemic heart disease were also registered. Statistical analysis by logistic regression was performed with 95% confidence intervals.Results: In the group of patients with RAO only the incidence of hypertension (OR: 3.33, 95% CI: 1.30–9.70, p = 0.014 as an average risk factor showed significant difference, but thrombophilic factors such as hyperfibrinogenemia (OR: 2.9, 95% CI: 1.29–6.57, p = 0.010 and the presence of FV (Leiden mutation (OR: 3.9, 95% CI: 1.43–10.96, p = 0.008 increased the chances of developing this disease.Conclusions: Our results support the assumption that thrombophilia may contribute to the development of RAO besides vascular damage due to the presence of cardiovascular risk factors. Further studies are needed, however, to justify the possible use of secondary prophylaxis in form of anticoagulant/antiplatelet therapy.Keywords: retinal arterial occlusion, risk factors, thrombophilia

Luuleaasta 1994 : parlamendi koosseis on selgunud / Barbi Pilvre

Index Scriptorium Estoniae

Pilvre, Barbi, 1963-

1995-01-01

Rannit, Aleksis. Nii näen sind ikka; Kangur, Kalju. Sõna sees olek; Traat, Mats. Koidu kätes; Rimmel, Rudolf. Setu netu; Suislepp, Harald. Köögertali kojutulek; Piir, Enno. Sunnitöölise Mekka; Üllaste, Leenart. Lind tormis; Hirv, Indrek. Taskuraamat (taskutähekerjus); Mirtem, Valev [Luhaäär, Ingvar]. Maithunad Eestis; Mirtem, Valev [Luhaäär, Ingvar]. Armuühtepühad; Mirtem, Valev [Luhaäär, Ingvar]. Tulevaas; Kurvits, Lembit. Matle laul; Lillemets, Enn. Olemise valge koer ehk Ingli kolju; Jessod, Mats [Jakobson, Mati]. Jah, luuletused; Jessod, Mats [Jakobson, Mati]. Ohjad Oti mäel; Jessod, Mats [Jakobson, Mati]. Poeetilisi prohmakaid; Ivar, Ivo. Riimiskid; Kilokalor, Kalle. Öösel näeb halvemini kui päeval; Trubetsky, Tõnu. Anarhia; Laanvee, Ervin. Jaa. Mina olen; Kuningas, Marko J. ...jääb USK, LOOTUS, ARMASTUS; Ruben, Arne. Ajakirjanik; Ollinovski, Jim [Ollino, Ott]. Luuletused; Toomik, Tõnu. 27 luuletust; Tosin, Ants. Õnnetähestik; Krüger, Urmas. Ka nii võib...; Kärner, Siim. Usseaid; Sikk, Heino. Võrokõstõlõ: poeem; Kollin, Viktor. Kodutunne; Alo, Ülo [Võsar, Ülo Alo]. Ööbikuvalgus; Sepp, Vello. Vigased pärlid; Palo, Wilhelm. Tuule-luuled; Soomets, Triin. Randmes unejanu; Soomets, Triin. Janu masinas; Ränik, Valeria. Ajast väljas; Kivi, Aita. Kalender-päevik Aita Kivi luuletustega; Maagemust, Maarika. Kaaludes kaldaid; Hiiussaar, Ann. Valgete uste taga; Kolkkanen, Imbi. Mina ja maailm; Mets, Neeme. Kesalill; Kolesnitshenko, Kaidi-Ly. Kaks silma; Kahro, Anne. Nälkjast!; Kabe, Aino. Tuulema mõtteriim. Raatma, Salme. Laululatern; Osila, Virve. Lootuse luiged; Isak, Asta. Valguse ja varjude vahel; Õunapuu, Meeli. Mööda teid ja radu

Potential drug–drug interactions in Alzheimer patients with behavioral symptoms

Directory of Open Access Journals (Sweden)

Pasqualetti G

2015-09-01

Full Text Available Giuseppe Pasqualetti, Sara Tognini, Valeria Calsolaro, Antonio Polini, Fabio Monzani Geriatrics Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy Abstract: The use of multi drug regimens among the elderly population has increased tremendously over the last decade although the benefits of medications are always accompanied by potential harm, even when prescribed at recommended doses. The elderly populations are particularly at an increased risk of adverse drug reactions considering comorbidity, poly-therapy, physiological changes affecting the pharmacokinetics and pharmacodynamics of many drugs and, in some cases, poor compliance due to cognitive impairment and/or depression. In this setting, drug–drug interaction may represent a serious and even life-threatening clinical condition. Moreover, the inability to distinguish drug-induced symptoms from a definitive medical diagnosis often results in addition of yet another drug to treat the symptoms, which in turn increases drug–drug interactions. Cognitive enhancers, including acetylcholinesterase inhibitors and memantine, are the most widely prescribed agents for Alzheimer’s disease (AD patients. Behavioral and psychological symptoms of dementia, including psychotic symptoms and behavioral disorders, represent noncognitive disturbances frequently observed in AD patients. Antipsychotic drugs are at high risk of adverse events, even at modest doses, and may interfere with the progression of cognitive impairment and interact with several drugs including anti-arrhythmics and acetylcholinesterase inhibitors. Other medications often used in AD patients are represented by anxiolytic, like benzodiazepine, or antidepressant agents. These agents also might interfere with other concomitant drugs through both pharmacokinetic and pharmacodynamic mechanisms. In this review we focus on the most frequent drug–drug interactions, potentially harmful, in AD patients with

Peptide gH625 enters into neuron and astrocyte cell lines and crosses the blood–brain barrier in rats

Directory of Open Access Journals (Sweden)

Valiante S

2015-03-01

Full Text Available Salvatore Valiante,1,* Annarita Falanga,2,3,* Luisa Cigliano,1 Giuseppina Iachetta,1 Rosa Anna Busiello,1 Valeria La Marca,1 Massimiliano Galdiero,4 Assunta Lombardi,1 Stefania Galdiero1,2 1Department of Biology, 2Department of Pharmacy, 3DFM Scarl, University of Naples Federico II, 4Department of Experimental Medicine, II University of Naples, Naples, Italy *These authors contributed equally to this paper and are considered joint first authors Abstract: Peptide gH625, derived from glycoprotein H of herpes simplex virus type 1, can enter cells efficiently and deliver a cargo. Nanoparticles armed with gH625 are able to cross an in vitro model of the blood–brain barrier (BBB. In the present study, in vitro experiments were performed to investigate whether gH625 can enter and accumulate in neuron and astrocyte cell lines. The ability of gH625 to cross the BBB in vivo was also evaluated. gH625 was administered in vivo to rats and its presence in the liver and in the brain was detected. Within 3.5 hours of intravenous administration, gH625 can be found beyond the BBB in proximity to cell neurites. gH625 has no toxic effects in vivo, since it does not affect the maximal oxidative capacity of the brain or the mitochondrial respiration rate. Our data suggest that gH625, with its ability to cross the BBB, represents a novel nanocarrier system for drug delivery to the central nervous system. These results open up new possibilities for direct delivery of drugs into patients in the field of theranostics and might address the treatment of several human diseases. Keywords: drug delivery, neurons, astrocytes, blood–brain barrier, peptide

Consequences of the 118A>G polymorphism in the OPRM1 gene: translation from bench to bedside?

Directory of Open Access Journals (Sweden)

Mura E

2013-05-01

Full Text Available Elisa Mura,1 Stefano Govoni,1 Marco Racchi,1 Valeria Carossa,1 Guglielmina Nadia Ranzani,2 Massimo Allegri,3,4 Ron HN van Schaik5 1Department of Drug Sciences, Centre of Excellence in Applied Biology, University of Pavia, Pavia, Italy; 2Department of Biology and Biotechnology, University of Pavia, Pavia, Italy; 3Pain Therapy Service, Foundation IRCCS San Matteo Hospital, Pavia, Italy; 4Department of Clinical, Surgical Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy; 5Department of Clinical Chemistry, Erasmus University Medical Center, Rotterdam, The Netherlands Abstract: The 118A>G single nucleotide polymorphism (SNP in the µ-opioid receptor (OPRM1 gene has been the most described variant in pharmacogenetic studies regarding opioid drugs. Despite evidence for an altered biological function encoded by this variant, this knowledge is not yet utilized clinically. The aim of the present review was to collect and discuss the available information on the 118A>G SNP in the OPRM1 gene, at the molecular level and in its clinical manifestations. In vitro biochemical and molecular assays have shown that the variant receptor has higher binding affinity for ß-endorphins, that it has altered signal transduction cascade, and that it has a lower expression compared with wild-type OPRM1. Studies using animal models for 118A>G have revealed a double effect of the variant receptor, with an apparent gain of function with respect to the response to endogenous opioids but a loss of function with exogenous administered opioid drugs. Although patients with this variant have shown a lower pain threshold and a higher drug consumption in order to achieve the analgesic effect, clinical experiences have demonstrated that patients carrying the variant allele are not affected by the increased opioid consumption in terms of side effects. Keywords: µ-opioid receptor, opioids, pharmacogenetics, pain, analgesia

Tinnitus: clinical experience of the psychosomatic connection

Directory of Open Access Journals (Sweden)

Salviati M

2014-02-01

Full Text Available Massimo Salviati,1 Francesco Saverio Bersani,1 Samira Terlizzi,1 Claudia Melcore,1 Roberta Panico,1 Graziella Francesca Romano,1 Guiseppe Valeriani,1 Francesco Macrì,1 Giancarlo Altissimi,2 Filippo Mazzei,2 Valeria Testugini,2 Luca Latini,1 Roberto Delle Chiaie,1 Massimo Biondi,1 Giancarlo Cianfrone21Department of Neurology and Psychiatry, Acute Psychiatric Ward (Servizio Psichiatrico di Diagnosi e Cura - SPDC, Sapienza University of Rome, Rome, Italy, 2Department of Sense Organs, Sapienza University of Rome, Rome, ItalyBackground: The connection between psychopathology and tinnitus is complex and not adequately studied. The aim of this study is to investigate the relationship between tinnitus and psychiatric comorbidities from different points of view: categorical, dimensional, temperamental, and perceived stress level.Methods: Two hundred and thirty-nine patients affected by tinnitus were recruited between January and October 2012. Patients underwent a preliminary battery of tests including the Tinnitus Handicap Inventory (THI, Symptom Check List (SCL90-R, Temperament and Character Inventory (TCI, and Stress-Related Vulnerability Scale (VRS, and eventually a full psychiatric evaluation. Results: One hundred and fourteen patients (48% of the total sample presented psychiatric comorbidity. Among these, a higher prevalence of depression, somatization, obsession, and anxiety was found. More than 41% of patients affected by decompensated tinnitus reported a family history of psychiatric disorders. Significant positive correlations between the psychopathological screening tools (SCL90-R and VRS and THI were found. Patients affected by comorbid psychiatric disorder showed specific temperamental and characterial predispositions.Conclusion: Psychiatric comorbidity in subjects affected by tinnitus is frequent. Stress can be considered as a factor leading to damage and dysfunction of the auditory apparatus. The vulnerability to neurotic disorders and

Gender stereotypes in occupational choice: a cross-sectional study on a group of Italian adolescents

Directory of Open Access Journals (Sweden)

Ramaci T

2017-04-01

Full Text Available Tiziana Ramaci,1 Monica Pellerone,1 Caterina Ledda,2 Giovambattista Presti,1 Valeria Squatrito,1 Venerando Rapisarda2 1Faculty of Human and Social Sciences, “Kore” University of Enna, Enna, 2Occupational Medicine, Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy Background: Gender beliefs represent cultural schemas for interpreting or making sense of the social and employment world, as they can influence attitudes, career aspirations, and the vocational decision process of young people, especially the adolescence.Materials and methods: This study examined the influence of gender stereotypes on the choice of career in adolescents. A group of 120 students were recruited to complete an ad hoc questionnaire, Scale of Perceived Occupational Self-Efficacy, and Semantic Differentials. The objectives of the study were to analyze the relationship between occupational self-efficacy and professional preference; to measure the influence of independent variables, such as age and gender, on the representation that students have of themselves and of the profession; and to identify the predictor variables of self-efficacy in the vocational decision.Results: Data showed that the distance between professional identity and social identity increases with age. Results underline that males seem to perceive themselves more self-efficient in military, scientific–technological, and agrarian professions than females. Furthermore, the type of job performed by parents appears to be a self-efficacy predictor variable in the choice of professions in the services area.Conclusion: Individuals’ perceived occupational self-efficacy, gender, age, and parents’ profession have implications for exploratory behavior. The conditions that make gender differences salient are more likely to favor self-representations of the career and consistent assessments with these representations. Keywords: adolescent, gender stereotypes, occupational

PREFACE: Structure and dynamics determined by neutron and x-ray scattering Structure and dynamics determined by neutron and x-ray scattering

Science.gov (United States)

Müller-Buschbaum, Peter

2011-06-01

Neutron and x-ray scattering have emerged as powerful methods for the determination of structure and dynamics. Driven by emerging new, powerful neutron and synchrotron radiation sources, the continuous development of new instrumentation and novel scattering techniques gives rise to exciting possibilities. For example, in situ observations become possible via a high neutron or x-ray flux at the sample and, as a consequence, morphological transitions with small time constants can be detected. This special issue covers a broad range of different materials from soft to hard condensed matter. Hence, different material classes such as colloids, polymers, alloys, oxides and metals are addressed. The issue is dedicated to the 60th birthday of Professor Winfried Petry, scientific director of the Research Neutron Source Heinz Maier-Leibnitz (FRM-II), Germany, advisor at the physics department for the Bayerische Elite-Akademie, chair person of the Arbeitsgemeinschaft Metall- und Materialphysik of the German Physical Society (DPG) and a member of the professional council of the German Science Foundation (Deutsche Forschungsgemeinschaft, DFG). We would like to acknowledge and thank all contributors for their submissions, which made this special issue possible in the first place. Moreover, we would like to thank the staff at IOP Publishing for helping us with the administrative aspects and for coordinating the refereeing process, and Valeria Lauter for the beautiful cover artwork. Finally, to the readers, we hope that you find this special issue a valuable resource that provides insights into the present possibilities of neutron and x-ray scattering as powerful tools for the investigation of structure and dynamics. Structure and dynamics determined by neutron and x-ray scattering contents In situ studies of mass transport in liquid alloys by means of neutron radiography F Kargl, M Engelhardt, F Yang, H Weis, P Schmakat, B Schillinger, A Griesche and A Meyer Magnetic spin

Psychosis in parkinsonism: an unorthodox approach

Directory of Open Access Journals (Sweden)

Onofrj M

2017-05-01

Full Text Available Marco Onofrj,1,2 Danilo Carrozzino,3,4 Aurelio D’Amico,1,2 Roberta Di Giacomo,1,2 Stefano Delli Pizzi,1 Astrid Thomas,1,2 Valeria Onofrj,5 John-Paul Taylor,6 Laura Bonanni1,2 1Department of Neuroscience Imaging and Clinical Sciences, University “G. d’Annunzio” of Chieti-Pescara, 2CE.S.I. University Foundation, 3Department of Psychological, Health, and Territorial Sciences, University “G. d’Annunzio” of Chieti-Pescara, Chieti, Italy; 4Psychiatric Research Unit, Psychiatric Centre North Zealand, Copenhagen University Hospital, Hillerød, Denmark; 5Department of Bioimaging, University Cattolica del Sacro Cuore, Rome, Italy; 6Institute of Neuroscience, Campus for Ageing and Vitality Newcastle University Newcastle upon Tyne, Newcastle upon Tyne, UK Abstract: Psychosis in Parkinson’s disease (PD is currently considered as the occurrence of hallucinations and delusions. The historical meaning of the term psychosis was, however, broader, encompassing a disorganization of both consciousness and personality, including behavior abnormalities, such as impulsive overactivity and catatonia, in complete definitions by the International Classification of Diseases-10 (ICD-10 and the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5. Our review is aimed at reminding that complex psychotic symptoms, including impulsive overactivity and somatoform disorders (the last being a recent controversial entity in PD, were carefully described in postencephalitic parkinsonism (PEP, many decades before dopaminergic treatment era, and are now described in other parkinsonisms than PD. Eminent neuropsychiatrists of the past century speculated that studying psychosis in PEP might highlight its mechanisms in other conditions. Yet, functional assessments were unavailable at the time. Therefore, the second part of our article reviews the studies of neural correlates of psychosis in parkinsonisms, by taking into account both theories on

Motivation to change and posttreatment temptation to drink: a multicenter study among alcohol-dependent patients

Directory of Open Access Journals (Sweden)

Fiabane E

2017-10-01

Full Text Available Elena Fiabane,1,2 Marcella Ottonello,1,3 Valeria Zavan,4 Caterina Pistarini,1 Ines Giorgi5 1Department of Physical and Rehabilitation Medicine, ICS Maugeri Spa SB, Institute of Genoa Nervi, Genoa, 2Department of Brain and Behavioral Sciences, University of Pavia, Pavia, 3Department of Medicine, PhD Program in Advance Sciences and Technologies in Rehabilitation Medicine and Sport, Università di Tor Vergata, Rome, 4Alcohol Unit, Addiction Department, Alessandria, 5Psychology Unit, ICS Maugeri Spa SB, Scientific Institute of Pavia, Pavia, Italy Background: An inpatient 28-day rehabilitation program for alcohol dependence is focused on detoxification, enhancing motivation to change, and coping strategies for the management of emotional distress and temptation to drink. The aims of the present study were to investigate 1 changes over time in motivation to change, anxiety, and depression in individuals undergoing residential rehabilitation treatment for alcohol addiction, and 2 which pretreatment factors are associated with posttreatment temptation to drink.Methods: We assessed 432 patients diagnosed with alcohol dependence based on the Diagnostic and Statistical Manual of Mental Disorders (Fourth Edition, Text Revision consecutively recruited from seven residential rehabilitation centers in Northern Italy. Patients were assessed by means of self-report questionnaires at the beginning of rehabilitation (pretreatment and before their hospital discharge (posttreatment regarding motivation to change and self-efficacy (motivation assessment of change – alcoholism version, readiness to change and temptation to drink (visual analog scales, and depression and anxiety (cognitive behavioral assessment – outcome evaluation.Results: Results showed an overall improvement in motivation to change and a significant reduction over time in depression and anxiety levels for the total sample, particularly patients with low baseline level of temptation to drink

Improvements in throat function and qualities of sore throat from locally applied flurbiprofen 8.75 mg in spray or lozenge format: findings from a randomized trial of patients with upper respiratory tract infection in the Russian Federation

Directory of Open Access Journals (Sweden)

Burova N

2018-06-01

Full Text Available Natalia Burova,1 Valeria Bychkova,2 Adrian Shephard3 1Federal State Establishment Clinical Diagnostic Medical Center, Saint Petersburg, Russia; 2Reckitt Benckiser (Russia, Moscow, Russia; 3Reckitt Benckiser Healthcare International Ltd, Slough, Berkshire, UK Objective: To assess the speed of relief provided by flurbiprofen 8.75 mg spray and lozenge and their effect on many of the different qualities and characteristics of throat pain and discomfort, and the many articulations of the broad term “sore throat” (ST. Patients and methods: Four hundred and forty adults with recent-onset, moderate-to-severe ST due to upper respiratory tract infection (URTI were randomized to a single dose of either flurbiprofen 8.75 mg spray (n=218 or flurbiprofen 8.75 mg lozenge (n=222. Throat swabs for bacterial culture were taken at baseline. ST relief was assessed at 1 minute, 1 and 2 hours post-dose using the Sore Throat Relief Rating Scale. The change from baseline at 1 and 2 hours post-dose in difficulty swallowing and swollen throat was assessed using the difficulty swallowing scale and the swollen throat scale, respectively. Patients’ experience of URTI symptoms was assessed using a URTI questionnaire at baseline and 2 hours post-dose. The change in Qualities of Sore Throat Index, a 10-item index of qualities of ST, from baseline at 2 hours post-dose was also measured. Results: ST relief was evident in the spray and the lozenge treatment groups at 1 minute, 1 and 2 hours post-dose (P>0.05. In both groups, scores for difficulty swallowing and swollen throat significantly improved at 1 and 2 hours post-dose compared with baseline. At 2 hours post-dose, the number of patients experiencing URTI symptoms that can be attributed to or associated with ST decreased relative to baseline. The mean change from baseline to 2 hours post-dose for each individual score on the Qualities of Sore Throat Index showed significant improvements for flurbiprofen spray and

Understanding Monitoring Technologies for Adults With Pain: Systematic Literature Review.

Science.gov (United States)

Rodríguez, Iyubanit; Herskovic, Valeria; Gerea, Carmen; Fuentes, Carolina; Rossel, Pedro O; Marques, Maíra; Campos, Mauricio

2017-10-27

information requests. A model of contextual information may be used by researchers to choose possible contextual information that may be monitored during studies on adults with pain. ©Iyubanit Rodríguez, Valeria Herskovic, Carmen Gerea, Carolina Fuentes, Pedro O Rossel, Maíra Marques, Mauricio Campos. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 27.10.2017.

Prospective study on prevalence, intensity, type, and therapy of acute pain in a second-level urban emergency department

Directory of Open Access Journals (Sweden)

Mura P

2017-12-01

Full Text Available Paolo Mura,1 Elisabetta Serra,1 Franco Marinangeli,2 Sebastiano Patti,3 Mario Musu,1 Ilenia Piras,3 Maria Valeria Massidda,1 Giorgio Pia,3 Maurizio Evangelista,4 Gabriele Finco1 1Department of Medical Sciences “M. Aresu”, University of Cagliari, Cagliari, Italy; 2Department of Anesthesiology, Intensive Care and Pain Medicine, University of L’Aquila, L’Aquila, Italy; 3Department of Emergency Medicine, Santissima Trinità Hospital, Cagliari, Italy; 4Department of Anesthesiology and Pain Medicine, Cattolica University, Rome, Italy Aim: Pain represents the most frequent cause for patient admission to emergency departments (EDs. Oligoanalgesia is a common problem in this field. The aims of this study were to assess prevalence and intensity of pain in patients who visited a second-level urban ED and to evaluate the efficacy of pharmacological treatment administered subsequent to variations in pain intensity. Methods: A 4-week prospective observational study was carried out on 2,838 patients who visited a second-level urban ED. Pain intensity was evaluated using the Numeric Rating Scale at the moment of triage. The efficacy of prescribed analgesic therapy was evaluated at 30 and 60 minutes, and at discharge. Data concerning pain intensity were classified as absent, slight, mild, or severe. Pain was evaluated in relation to the prescribed therapy. Results: Pain prevalence was 70.7%. Traumatic events were the primary cause in most cases (40.44%, followed by pain linked to urologic problems (13.52%, abdominal pain (13.39%, and nontraumatic musculoskeletal pain (7.10%. Only 32.46% of patients were given pharmacological therapy. Of these, 76% reported severe pain, 19% moderate, and 5% slight, and 66% received nonsteroidal anti-inflammatory drugs or paracetamol, 4% opioids, and 30% other therapies. A difference of at least 2 points on the Numerical Rating Scale was observed in 84% of patients on reevaluation following initial analgesic therapy

Editorial, n. 12, 2001

Directory of Open Access Journals (Sweden)

Editor Encontros Bibli

2001-01-01

Full Text Available EDITORIAL, n. 12, 2001 Este número da Encontros Bibli apresenta diferentes abordagens de questões relativas à sociedade do conhecimento. Esta sociedade vem acompanhada de uma evolução tecnológica que afeta, em diferentes graus, todos os países do mundo, produzindo impactos de natureza econômica, política, social e cultural. Tais impactos necessitam de parâmetros para sua análise e avaliação. A medição de bens intangíveis, neste caso, provenientes do uso das tecnologias da informação e da comunicação, é uma tarefa complexa. O artigo do professor Michel Menou, da City University, de Londres, apresenta uma metodologia original para análise desses indicadores na sociedade atual. O relato de pesquisa da professora Clarice Fortkamp Caldin, do Departamento de Ciência da Informação da UFSC, aborda o processo de leitura como função terapêutica. Este trabalho é baseado na sua dissertação de mestrado e representa um foco de abordagem pouco usual na Ciência da Informação. O professor Francisco das Chagas de Souza, também do Departamento de Ciência da Informação da UFSC, apresenta uma análise de sua experiência no ensino de fundamentos teóricos da Biblioteconomia. A estudante Maria Elizabeth Horn Pepulim, do Curso de Biblioteconomia da UFSC, reflete sobre o papel do bibliotecário na sociedade da informação, ressaltando os dilemas, atribuições e responsabilidades deste profissional no mundo globalizado. Esta edição divulga ainda uma pesquisa sobre bibliotecas públicas, sociedade da informação e tecnologia, que está sendo desenvolvida pelos colegas do Instituto de Investigaciones Bibliotecológicas da Universidad de Buenos Aires: Elsa Barber, Nicolás Tripaldi, Silvia Pisano, Valeria Werner, Sofia D´Alessandro, Sandra Romagnoli, Verónica Parsiale, Carolina Gregui e Gabriela De Pedro. Miriam Vieira da Cunha, editora Disponibilizado na WWW em 28/12/2001. Enc. Bibli: R. Eletr. Bibliotecon. Ci. Inf., ISSN 1518

Bioequivalence study of a new sildenafil 100 mg orodispersible film compared to the conventional film-coated 100 mg tablet administered to healthy male volunteers

Directory of Open Access Journals (Sweden)

Radicioni M

2017-04-01

Full Text Available Milko Radicioni,1 Chiara Castiglioni,1 Andrea Giori,2 Irma Cupone,3 Valeria Frangione,4 Stefano Rovati4 1CROSS Research S.A., Phase I Unit, Arzo, Switzerland; 2IBSA Farmaceutici Italia, Lodi, Italy; 3Bouty S.p.A., Strada Padana Superiore, Cassina De’ Pecchi, Italy; 4IBSA Institut Biochimique S.A., Pambio-Noranco, Switzerland Abstract: A new orodispersible film formulation of the phosphodiesterase type 5 inhibitor, sildenafil, has been developed to examine the advantages of an orally disintegrating film formulation and provide an alternative to the current marketed products for the treatment of erectile dysfunction. The pharmacokinetics of the sildenafil 100 mg orodispersible film (IBSA was compared to that of the conventional marketed 100 mg film-coated tablet (Viagra® after single-dose administration to 53 healthy male volunteers (aged 18–51 years in a randomized, open, two-way crossover bioequivalence study. Each subject received a single oral dose of 100 mg of sildenafil as test or reference formulation administered under fasting conditions at each of the two study periods according to a randomized crossover design. There was a washout interval of ≥7 days between the two administrations of the investigational medicinal products. Blood samples for pharmacokinetic analysis were collected up to 24 h post-dosing. The primary objective was to compare the rate (peak plasma concentration; Cmax and extent (area under the curve [AUC] from administration to last observed concentration time; AUC0–t of sildenafil absorption after single-dose administration of test and reference. Secondary endpoints were observed to describe the plasma pharmacokinetic profiles of sildenafil and its metabolite N-desmethyl-sildenafil relative bioavailability and safety profile after single-dose administration. The mean sildenafil and N-desmethyl-sildenafil plasma concentration–time profiles up to 24 h after single-dose administration of sildenafil 100 mg

New and emerging contraceptives: a state-of-the-art review

Directory of Open Access Journals (Sweden)

Bahamondes L

2014-02-01

Full Text Available Luis Bahamondes, M Valeria Bahamondes Human Reproduction Unit, Department of Obstetrics and Gynaecology, Faculty of Medical Sciences, University of Campinas and National Institute of Hormones and Women's Health, Campinas, SP, Brazil Background: The first hormonal contraceptive was introduced onto the market in several countries 50 years ago; however, the portfolio of contraceptive methods remains restricted with regards to their steroid composition, their cost, and their ability to satisfy the requirements of millions of women/couples in accordance with their different reproductive intentions, behaviors, cultures, and settings. Methods: A literature review was conducted using Medline, Embase, and Current Contents databases, up to September 1, 2013 to identify publications reporting new contraceptives in development using combinations of the search terms: contraception, contraceptives, oral contraceptives, patch, vaginal ring, implants, intrauterine contraceptives, and emergency contraception (EC. Also, several experts in the field were also consulted to document ongoing projects on contraception development. Additionally, the Clinicaltrial.gov website was searched for ongoing studies on existing contraceptive methods and new and emerging female contraceptives developed over the past 5 years. Information was also obtained from the pharmaceutical industry. Results: Early sexual debut and late menopause means that women may require contraception for up to 30 years. Although oral, injectable, vaginal, transdermal, subdermal, and intrauterine contraceptives are already available, new contraceptives have been developed in an attempt to reduce side effects and avoid early discontinuation, and to fulfill women's different requirements. Research efforts are focused on replacing ethinyl-estradiol with natural estradiol to reduce thrombotic events. In addition, new, less androgenic progestins are being introduced and selective progesterone receptor

Frequency and risk factors associated with dry eye in patients attending a tertiary care ophthalmology center in Mexico City

Directory of Open Access Journals (Sweden)

Martinez JD

2016-07-01

Full Text Available Jaime D Martinez,1 Anat Galor,2,3 Nallely Ramos-Betancourt,1 Andrés Lisker-Cervantes,1 Francisco Beltrán,1 Jorge Ozorno-Zárate,1 Valeria Sánchez-Huerta,1 Marco-Antonio Torres-Vera,1 Everardo Hernández-Quintela1 1Cornea and External Diseases Service, Asociación Para Evitar la Ceguera en Mexico (Association to prevent blindness in Mexico, Universidad Nacional Autónoma de México, Mexico City, Mexico; 2Department of Ophthalmology, Miami Veterans Affairs Medical Center, 3Cornea and External Diseases Division, Bascom Palmer Eye Institute, University of Miami, Miami, FL, USA Purpose: The purpose of this study was to ascertain the frequency and risk factors of dry eye (DE among patients attending a tertiary care ophthalmology center in Mexico.Methods: Approximately 338 consecutive new patients attending a tertiary care ophthalmology center in Mexico City underwent an ocular surface examination, which included tear film break-up time, fluorescein corneal staining, Schirmer’s test, and evaluation of meibum quality. Symptoms of DE were evaluated by the Ocular Surface Disease Index and Dry Eye Questionnaire-5. Information on demographics, exposures, past medical and ocular history, and medications was also collected.Results: The frequency of severe DE symptoms was found to be 43% based on the Ocular Surface Disease Index and 30% based on Dry Eye Questionnaire-5. Risk factors significantly associated with increased DE symptoms included dry mouth and gastrointestinal ulcer medications. With regard to signs, aqueous tear deficiency was a less-frequent finding (22% in our population than evaporative deficiency (94%. Risk factors associated with aqueous tear deficiency were dry mouth and diuretic use. No risk factors were associated with evaporative deficiency. Risk factors associated with meibomian gland dysfunction included old age, male sex, arthritis, and use of an antihypertensive. The only risk factor associated with corneal staining was dry

the Irkutsk sixtiers

Directory of Open Access Journals (Sweden)

Elena Grigoryeva

2014-01-01

Full Text Available Having come from the capitals to Irkutsk in the late 50s – early 60s, those foplings, idealists, maximalists and daydreamers started a new stage full of brave ideas and incredible realizations.There is a popular belief that the architecture of the 1960s is not architecture at all. Forced to be ascetic, this architecture is often unphotogenic. Nowadays it suffers from advertisements, signs and alterations; sometimes it is utterly distorted being wrapped in shining foil of modern materials to satisfy a new owner.The editorial staff’s task was to return authors to the anonymous buildings of the 1960s.We reopen for ourselves and our readers several iconic buildings, among which there are not only Pavlov’s buildings that have all-Union and even international recognition, but also the Palace of Sports by Shmatkov, the Medical Institute by Kolpikov, the terraced hospital on the embankment and the Art School by Shilov, the polyclinic on Sverdlov Street by Nechvolodov, kindergartens and hostels by Stanislav Grigoryev, the railway station in Novo-Lenino by Nechitailo…Among them there are also residential buildings by Valeria Aptekman worked out for the center and adequately sized for man and historical Irkutsk. And its interpretation made by Antipin and Pavlov for Zvezdochka microdistrict that was published in PB 26.The reader will see an unrealized Civilian Ceremonies Hall by Khaldeev – one of the opportunities lost by Irkutsk.Voronezhsky’s sketches for the Musical Theatre, which were later taken into consideration by Moscow authors.Residential neighborhoods Headwater (Solnechny and Pervomaisky, microdistricts Baikalsky and Sinyushina Gora by Voronezhsky, Bukh, Pavlov and Grigoryev demonstrate work with systems of public spaces, pedestrian axes, courtyards and recreations that are so urgent now in the 21st century.And, finally, the bright ideas in urban planning by Voroneznsky that predetermined the city development for many years to come �

The complex of PAMAM-OH dendrimer with Angiotensin (1–7 prevented the disuse-induced skeletal muscle atrophy in mice

Directory of Open Access Journals (Sweden)

Márquez-Miranda V

2017-03-01

Full Text Available Valeria Márquez-Miranda,1,2,* Johanna Abrigo,3,4,* Juan Carlos Rivera,3,4 Ingrid Araya-Durán,1 Javier Aravena,3,4 Felipe Simon,3,4 Nicolás Pacheco,1 Fernando Danilo González-Nilo,1,2,5 Claudio Cabello-Verrugio3,4 1Center for Bioinformatics and Integrative Biology (CBIB, Facultad de Ciencias Biologicas, Universidad Andres Bello, Santiago, 2Fundación Fraunhofer Chile Research, Las Condes, 3Departamento de Ciencias Biologicas, Facultad de Ciencias Biologicas & Facultad de Medicina, Universidad Andres Bello, 4Millennium Institute on Immunology and Immunotherapy, Santiago, 5Centro Interdisciplinario de Neurociencia de Valparaíso, Facultad de Ciencias, Universidad de Valparaíso, Valparaíso, Chile *These authors contributed equally to this work Abstract: Angiotensin (1–7 (Ang-(1–7 is a bioactive heptapeptide with a short half-life and has beneficial effects in several tissues – among them, skeletal muscle – by preventing muscle atrophy. Dendrimers are promising vehicles for the protection and transport of numerous bioactive molecules. This work explored the use of a neutral, non-cytotoxic hydroxyl-terminated poly(amidoamine (PAMAM-OH dendrimer as an Ang-(1–7 carrier. Bioinformatics analysis showed that the Ang-(1–7-binding capacity of the dendrimer presented a 2:1 molar ratio. Molecular dynamics simulation analysis revealed the capacity of neutral PAMAM-OH to protect Ang-(1–7 and form stable complexes. The peptide coverage ability of the dendrimer was between ~50% and 65%. Furthermore, an electrophoretic mobility shift assay demonstrated that neutral PAMAM-OH effectively bonded peptides. Experimental results showed that the Ang-(1–7/PAMAM-OH complex, but not Ang-(1–7 alone, had an anti-atrophic effect when administered intraperitoneally, as evaluated by muscle strength, fiber diameter, myofibrillar protein levels, and atrogin-1 and MuRF-1 expressions. The results of the Ang-(1–7/PAMAM-OH complex being intraperitoneally

Topoisomerase II alpha and TLE3 as predictive markers of response to anthracycline and taxane-containing regimens for neoadjuvant chemotherapy in breast cancer

Directory of Open Access Journals (Sweden)

Susini T

2014-11-01

Full Text Available Tommaso Susini,1 Barbara Berti,1 Carlo Carriero,1 Ketty Tavella,2 Jacopo Nori,3 Ermanno Vanzi,3 Cecilia Molino,1 Mariarosaria Di Tommaso,1 Marco Santini,1 Valeria Saladino,4 Simonetta Bianchi4 1Department of Health Science, Gynecology Section, 2Department of Health Science, Chemotherapy Section, University of Florence, Italy; 3Diagnostic Senology Unit, Azienda Ospedaliera-Universitaria Careggi, Florence, Italy; 4Department of Surgery and Translational Medicine, Pathology Unit, University of Florence, Italy Purpose: Anthracyclines and taxanes are considered the standard for neoadjuvant chemotherapy of breast cancer, although they are often associated with serious side effects and wide variability of individual response. In this study, we analyzed the value of topoisomerase II alpha (TOP2A and transducin-like enhancer of split 3 (TLE3 as predictive markers of response to therapy with anthracyclines and taxanes. Materials and methods: TOP2A and TLE3 protein expressions were evaluated using immunohistochemistry on 28 samples, obtained by core needle biopsy in patients with locally advanced breast carcinoma, subsequently subjected to epirubicin- and paclitaxel-based neoadjuvant chemotherapy. The immunohistochemical staining was correlated with the clinical response measured by the tumor size reduction evaluated by breast magnetic resonance imaging, prior and after chemotherapy, and by pathologic evaluation of the surgical specimen. Results: Neoadjuvant chemotherapy achieved a size reduction in 26/28 tumors (92.9%, with an average percentage decrease of 45.6%. A downstaging was achieved in 71.4% of the cases of locally advanced carcinoma. TOP2A positivity was correlated with a greater reduction in tumor diameter (P=0.06; negative staining for TLE3 was predictive of a better response to neoadjuvant chemotherapy (P=0.07. A higher reduction in tumor diameter (P=0.03 was also found for tumors that were concurrently TLE3-negative and TOP2A

BARBIE®: AN IRONIC IMAGERY IN TODAY’S CONSUMER CULTURE A Study on ‘Barbie® Flu’ in Odessa, Ukraine

Directory of Open Access Journals (Sweden)

Melania Shinta Harendika

2017-04-01

Full Text Available Barbie® is one of the attention-grabbing American cultural products. In a consumer culture, in which popular heroes are no longer the mighty, but the movie stars and beautiful people of leisure (Featherstone, 1991, Barbie® plays an important role in constructing ones’ such new standards as youth, beauty, energy, fitness, romance, luxury, enjoyment, and fun. This new standards encourage others to imitate it, like what three girls in Odessa, Ukraine do – Anastasiya Shpagina, Valeria Lukyanova, and Olga Oleynik. This phenomenon is then famous with the name ‘Barbie® flu’. What is it about this doll that makes it such a phenomenon? What are the main factors that have allowed Barbie to dominate the doll market? Zygmunt Bauman’s theory of consumer culture and Stuart Hall’s theory of circuit of culture are implemented in this phenomenological study. In this study, furthermore, the data is gathered from such informative documents as research journals and samples of free writing about the topic. The result of this study shows that because of the mass production and consumption of Barbie®, such new identities of women appear as modern society’s eagerness to look better, younger, and more attractive. Behind its success in constructing social ideas of the new standards of women appearance, Barbie® actually holds a seamy side in which she promotes an unrealistic idea of body image for the three girls in Odessa, leading to several risks. This condition then creates a new regulation in which many people from the opposite side create new propaganda not to idolize Barbie® anymore. Beyond these contrary facts, Barbie® proves that the society, represented by the Barbie® flu girls, is being ‘trapped’ in a consumer culture, a culture in which everybody wants to be like their idols, whatever the condition is. Understanding American culture, i.e. Barbie®, is important to raise one’s awareness that cultural products can also present any

Synthesis and characterization of different immunogenic viral nanoconstructs from rotavirus VP6 inner capsid protein

Directory of Open Access Journals (Sweden)

Bugli F

2014-05-01

Full Text Available Francesca Bugli,1 Valeria Caprettini,2 Margherita Cacaci,1 Cecilia Martini,1 Francesco Paroni Sterbini,1 Riccardo Torelli,1 Stefano Della Longa,3 Massimiliano Papi,4 Valentina Palmieri,4 Bruno Giardina,5 Brunella Posteraro,1 Maurizio Sanguinetti,1 Alessandro Arcovito5 1Istituto di Microbiologia, Università Cattolica del Sacro Cuore, 2Dipartimento di Fisica, Sapienza Università di Roma, Rome, 3Dipartimento di Medicina Clinica, Sanità Pubblica, Scienze della Vita e dell’Ambiente, Università dell’Aquila, L’Aquila, 4Istituto di Fisica, 5Istituto di Biochimica e Biochimica Clinica, Università Cattolica del Sacro Cuore, Rome, Italy Abstract: In order to deliver low-cost viral capsomeres from a large amount of soluble viral VP6 protein from human rotavirus, we developed and optimized a biotechnological platform in Escherichia coli. Specifically, three different expression protocols were compared, differing in their genetic constructs, ie, a simple native histidine-tagged VP6 sequence, VP6 fused to thioredoxin, and VP6 obtained with the newly described small ubiquitin-like modifier (SUMO fusion system. Our results demonstrate that the histidine-tagged protein does not escape the accumulation in the inclusion bodies, and that SUMO is largely superior to the thioredoxin-fusion tag in enhancing the expression and solubility of VP6 protein. Moreover, the VP6 protein produced according to the SUMO fusion tag displays well-known assembly properties, as observed in both transmission electron microscopy and atomic force microscopy images, giving rise to either VP6 trimers, 60 nm spherical virus-like particles, or nanotubes a few micron long. This different quaternary organization of VP6 shows a higher level of immunogenicity for the elongated structures with respect to the spheres or the protein trimers. Therefore, the expression and purification strategy presented here – providing a large amount of the viral capsid protein in the native

Efficacy of flurbiprofen 8.75 mg delivered as a spray or lozenge in patients with sore throat due to upper respiratory tract infection: a randomized, non-inferiority trial in the Russian Federation

Directory of Open Access Journals (Sweden)

Radkova E

2017-07-01

Full Text Available Eugenia Radkova,1 Natalia Burova,2 Valeria Bychkova,3 Robert DeVito4 1OCT Clinical Trials, Saint Petersburg, Russia; 2Federal State Establishment Clinical Diagnostic Medical Center, Saint Petersburg, Russia; 3Reckitt Benckiser (Russia, Moscow, Russia; 4Reckitt Benckiser, Parsippany, NJ, USA Objective: To assess the efficacy of flurbiprofen 8.75 mg delivered as a spray or lozenge in patients with sore throat due to upper respiratory tract infection (URTI.Materials and methods: This multicenter, double-blind, double-dummy, non-inferiority study randomized 440 adults with recent-onset, moderate-to-severe sore throat due to URTI to a single dose of either flurbiprofen 8.75 mg spray (n=218 or flurbiprofen 8.75 mg lozenge (n=222. The presence or absence of beta-hemolytic streptococci (A or C was confirmed by culture tests (throat swab. The primary efficacy end point was the difference from baseline to 2 hours post-dose in sore throat pain intensity scale (STPIS pain intensity difference [PID] 2h, a validated 100 mm visual analog scale (from 0=“no pain” to 100=“severe pain”, with a non-inferiority margin of −6 mm. Secondary end points included STPIS PID at 1 hour (STPIS PID 1h and over 2 hours (STPIS sum of sore throat pain intensity differences [SPID]0–2h and ratings of patient satisfaction and investigator assessment of drug efficacy at 2 hours. Safety (adverse events [AEs] was also assessed.Results: Reductions in sore throat pain intensity at 2 hours (STPIS PID 2h were similar for spray (least square mean −40.51 and lozenge (−40.10 (difference: 0.41, 95% confidence interval [95% CI] −3.20, 4.01, with non-inferiority demonstrated. Subgroup analyses showed similar efficacy (STPIS PID 2h for patients testing positive or negative for Strep A or C. There was no significant difference between spray and lozenge in STPIS PID 1h or STPIS SPID0–2h, and patient satisfaction and investigators’ assessment of efficacy at 2�

Combined isosorbide dinitrate and ibuprofen as a novel therapy for muscular dystrophies: evidence from Phase I studies in healthy volunteers

Directory of Open Access Journals (Sweden)

Cossu MV

2014-05-01

Full Text Available Maria Vittoria Cossu,1 Dario Cattaneo,1 Serena Fucile,1 Paolo Pellegrino,1 Sara Baldelli,1 Valeria Cozzi,1 Amedeo Capetti,2 Emilio Clementi1,3 1Unit of Clinical Pharmacology, Consiglio Nazionale delle Ricerche Institute of Neuroscience, Department of Biomedical and Clinical Sciences, University Hospital “Luigi Sacco”, Università di Milano, Milan, Italy; 2Unit of Infectious Diseases, University Hospital “Luigi Sacco”, Milan, Italy; 3Scientific Institute, IRCCS Eugenio Medea, Bosisio Parini, Lecco, Italy Abstract: We designed two Phase I studies that assessed healthy volunteers in order to evaluate the safety and to optimize the dosing of the combination of the drugs isosorbide dinitrate, a nitric oxide donor, and ibuprofen, a nonsteroidal antiinflammatory drug. We designed these studies with the aim of designing a Phase II trial to evaluate the drugs’ efficacy in patients affected by Duchenne muscular dystrophy. For the first trial, ISOFEN1, a single-dose, randomized-sequence, open-label, active control, three-treatment cross-over study, was aimed at comparing the pharmacokinetics of ibuprofen 200 mg and isosorbide dinitrate 20 mg when given alone and concomitantly. The pharmacokinetics of ibuprofen given alone versus ibuprofen given concomitantly with isosorbide dinitrate were similar, as documented by the lack of statistically significant differences in the main drug’s pharmacokinetic parameters (time to maximal concentration [Tmax], maximal concentration [Cmax], area under the curve [AUC]0–t, and AUC0–∞. Similarly, we found that the coadministration of ibuprofen did not significantly affect the pharmacokinetics of isosorbide dinitrate. No issues of safety were detected. The second trial, ISOFEN2, was a single-site, dose titration study that was designed to select the maximum tolerated dose for isosorbide dinitrate when coadministered with ibuprofen. Eighteen out of the 19 enrolled subjects tolerated the treatment well, and

COPD patients’ self-reported adherence, psychosocial factors and mild cognitive impairment in pulmonary rehabilitation

Directory of Open Access Journals (Sweden)

Pierobon A

2017-07-01

Full Text Available Antonia Pierobon,1 Elisa Sini Bottelli,1 Laura Ranzini,1 Claudio Bruschi,2 Roberto Maestri,3 Giorgio Bertolotti,4 Marinella Sommaruga,5 Valeria Torlaschi,1 Simona Callegari,1 Anna Giardini1 1Psychology Unit, 2Department of Pulmonary Rehabilitation, 3Department of Biomedical Engineering, Istituti Clinici Scientifici Maugeri, IRCCS, Montescano, 4Psychology Unit, Istituti Clinici Scientifici Maugeri, IRCCS, Tratate, 5Clinical Psychology and Social Support Unit, Istituti Clinici Scientifici Maugeri, IRCCS, Camaldoli, Italy Abstract: In addition to clinical comorbidities, psychological and neuropsychological problems are frequent in COPD and may affect pulmonary rehabilitation delivery and outcome. The aims of the study were to describe a COPD population in a rehabilitative setting as regards the patients depressive symptoms, anxiety, mild cognitive impairment (MCI and self-reported adherence and to analyze their relationships; to compare the COPD sample MCI scores with normative data; and to investigate which factors might predict adherence to prescribed physical exercise. This was a multicenter observational cross-sectional study. Of the 117 eligible stable COPD inpatients, 84 were enrolled according to Global initiative for chronic Obstructive Lung Disease (GOLD criteria (mainly in Stage III–IV. The assessment included Mini Mental State Examination (MMSE, Montreal Cognitive Assessment (MoCA, anxiety, depression and self-reported pharmacological and nonpharmacological adherence. From the MMSE, 3.6% of patients were found to be impaired, whereas from the MoCA 9.5% had a likely MCI. Patients referred had mild-severe depression (46.7%, anxiety (40.5%, good pharmacological adherence (80.3% and difficulties in following prescribed diet (24.1% and exercise (51.8%; they struggled with disease acceptance (30.9% and disease limitations acceptance (28.6%. Most of them received good family (89% or social (53% support. Nonpharmacological adherence

Biochemical characterization of the interactions between doxorubicin and lipidic GM1 micelles with or without paclitaxel loading

Directory of Open Access Journals (Sweden)

Leonhard V

2015-05-01

Full Text Available Victoria Leonhard,1,2 Roxana V Alasino,1,2 Ismael D Bianco,1–3 Ariel G Garro,1 Valeria Heredia,1 Dante M Beltramo1,2,4 1Centro de Excelencia en Productos y Procesos de Córdoba (CEPROCOR, Córdoba, Argentina; 2Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET, Buenos Aires, Argentina; 3Departamento de Ciencias Exactas, Físicas y Naturales, Universidad Nacional de La Rioja, La Rioja, Argentina; 4Laboratorio de Biotecnología, Facultad de Ciencias Químicas, Universidad Católica de Córdoba, Córdoba, Argentina Abstract: Doxorubicin (Dox is an anthracycline anticancer drug with high water solubility, whose use is limited primarily due to significant side effects. In this study it is shown that Dox interacts with monosialoglycosphingolipid (GM1 ganglioside micelles primarily through hydrophobic interactions independent of pH and ionic strength. In addition, Dox can be incorporated even into GM1 micelles already containing highly hydrophobic paclitaxel (Ptx. However, it was not possible to incorporate Ptx into Dox-containing GM1 micelles, suggesting that Dox could be occupying a more external position in the micelles. This result is in agreement with a higher hydrolysis of Dox than of Ptx when micelles were incubated at alkaline pH. The loading of Dox into GM1 micelles was observed over a broad range of temperature (4°C–55°C. Furthermore, Dox-loaded micelles were stable in aqueous solutions exhibiting no aggregation or precipitation for up to 2 months when kept at 4°C–25°C and even after freeze–thawing cycles. Upon exposure to blood components, Dox-containing micelles were observed to interact with human serum albumin. However, the amount of human serum albumin that ended up being associated to the micelles was inversely related to the amount of Dox, suggesting that both could share their binding sites. In vitro studies on Hep2 cells showed that the cellular uptake and cytotoxic activity of Dox and Ptx from the

Ecuadorian Cancer Patients' Preference for Information and Communication Technologies: Cross-Sectional Study.

Science.gov (United States)

Cherrez Ojeda, Ivan; Vanegas, Emanuel; Torres, Michell; Calderón, Juan Carlos; Calero, Erick; Cherrez, Annia; Felix, Miguel; Mata, Valeria; Cherrez, Sofia; Simancas, Daniel

2018-02-20

investigate how to develop and promote ICT-based resources more effectively to engage the outcomes of cancer patients. The widespread use of ICTs narrows the gap between cancer patients with restricted socioeconomic conditions and those with wealth and easily available technological means, thereby opening up new possibilities in low-income countries. ©Ivan Cherrez Ojeda, Emanuel Vanegas, Michell Torres, Juan Carlos Calderón, Erick Calero, Annia Cherrez, Miguel Felix, Valeria Mata, Sofia Cherrez, Daniel Simancas. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 20.02.2018.

Clinical differences among the elderly admitted to the emergency department for accidental or unexplained falls and syncope

Directory of Open Access Journals (Sweden)

Pasqualetti G

2017-04-01

Full Text Available Giuseppe Pasqualetti,1 Valeria Calsolaro,1 Giacomo Bini,1 Umberto Dell’Agnello,1 Marco Tuccori,2 Alessandra Marino,2 Alice Capogrosso-Sansone,2 Martina Rafanelli,3 Massimo Santini,4 Eugenio Orsitto,4 Andrea Ungar,3 Corrado Blandizzi,2 Fabio Monzani1 On behalf of the ANCESTRAL-ED study group 1Geriatrics Unit, 2Pharmacology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, 3Syncope Unit, Geriatric and Intensive Care Medicine, AOU Careggi and University of Florence, Florence, 4Emergency Department, University Hospital of Pisa, Pisa, Italy Abstract: It is difficult to distinguish unexplained falls (UFs from accidental falls (AFs or syncope in older people. This study was designed to compare patients referred to the emergency department (ED for AFs, UFs or syncope. Data from a longitudinal study on adverse drug events diagnosed at the ED (ANCESTRAL-ED in older people were analyzed in order to select cases of AF, syncope, or UF. A total of 724 patients (median age: 81.0 [65–105] years, 66.3% female were consecutively admitted to the ED (403 AF, 210 syncope, and 111 UF. The number of psychotropic drugs was the only significant difference in patients with AF versus those with UF (odds ratio [OR] 1.44; 95% confidence interval 1.17–1.77. When comparing AF with syncope, female gender, musculoskeletal diseases, dementia, and systolic blood pressure >110 mmHg emerged as significantly associated with AF (OR 0.40 [0.27–0.58], 0.40 [0.24–0.68], 0.35 [0.14–0.82], and 0.31 [0.20–0.49], respectively, while valvulopathy and the number of antihypertensive drugs were significantly related to syncope (OR 2.51 [1.07–5.90] and 1.24 [1.07–1.44], respectively. Upon comparison of UF and syncope, the number of central nervous system drugs, female gender, musculoskeletal diseases, and SBP >110 mmHg were associated with UF (OR 0.65 [0.50–0.84], 0.52 [0.30–0.89], 0.40 [0.20–0.77], and 0.26 [0.13–0.55], respectively

The nasal delivery of nanoencapsulated statins – an approach for brain delivery

Directory of Open Access Journals (Sweden)

Clementino A

2016-12-01

Full Text Available Adryana Clementino,1,2 Mellissa Batger,3 Gabriela Garrastazu,2,3 Michele Pozzoli,3 Elena Del Favero,4 Valeria Rondelli,4 Bianca Gutfilen,5 Thiago Barboza,5 Maria B Sukkar,3 Sergio A L Souza,5 Laura Cantù,4 Fabio Sonvico1,3 1Department of Pharmacy, University of Parma, Parma, Italy; 2National Council for Scientific and Technological Development – CNPq, Brasilia, Brazil; 3Graduate School of Health – Pharmacy, University of Technology Sydney, Ultimo, NSW, Australia; 4Department of Medical Biotechnologies and Translational Medicine, LITA, University of Milan, Segrate, Italy; 5Laboratório de Marcação de Células e Moléculas, Department of Radiology, Faculty of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil Purpose: Along with their cholesterol-lowering effect, statins have shown a wide range of pleiotropic effects potentially beneficial to neurodegenerative diseases. However, such effects are extremely elusive via the conventional oral administration. The purpose of the present study was to prepare and characterize the physicochemical properties and the in vivo biodistribution of simvastatin-loaded lecithin/chitosan nanoparticles (SVT-LCNs suitable for nasal administration in view of an improved delivery of the statins to the brain. Materials and methods: Chitosan, lecithin, and different oil excipients were used to prepare nanocapsules loaded with simvastatin. Particle size distribution, surface charge, structure, simvastatin loading and release, and interaction with mucus of nanoparticles were determined. The nanoparticle nasal toxicity was evaluated in vitro using RPMI 2651 nasal cell lines. Finally, in vivo biodistribution was assessed by gamma scintigraphy via Tc99m labeling of the particles. Results: Among the different types of nanoparticles produced, the SVT-LCN_MaiLab showed the most ideal physicochemical characteristics, with small diameter (200 nm, positive surface charge (+48 mV and high encapsulation

Astronomy in the Classroom: Why? (Spanish Title: Astronomía en la Clase: ¿Por Qué?) Astronomia na Sala de Aula: Por Quê?

Science.gov (United States)

Daros Gama, Leandro; Bagdonas Henrique, Alexandre

2010-07-01

particular, é foco deste ensaio: a astronomia. Em que sentido e em que medida valeria a pena abordá-la em aulas, seja de ciências, seja de astronomia especificamente, ou em disciplinas afins? Discutimos neste texto alguns aspectos das vantagens de se tratar essa área do conhecimento nas escolas, levando em conta as dimensões epistemológica e axiológica da astronomia, à luz da visão da ciência como um diálogo inteligente com o mundo, de Bachelard, além da proposta de problematização do conhecimento, de Paulo Freire. Proporemos que de fato a astronomia não precisa ser vista como apenas um novo conjunto de conteúdos a serem ensinados, mas figura como conjunto de temas motivadores para discussões histórico-filosóficas, além de permitir a abordagem de conceitos típicos de outras disciplinas.

Homenaje al Profesor Académico Juan Di Doménico.

Directory of Open Access Journals (Sweden)

Roberto Vergara Támara

2004-03-01

Nápoles en 1924 donde completó su bachillerato Académico en el Liceo Umberto 1. Estudió medicina desde 1931 y se graduó en 1937. En 1938 aprobó los exámenes estatales para ejercer la medicina en Italia.

Casado con Carmen Buraglia Stella (1947-1992. Sus hijos: Juan Francisco, Cirujano y Claudio Maurizio, Arquitecto, constructor. Sus nietos: Stefano, Eric, Claudia y Valeria.
Viajó a Estados Unidos, se especializó en Cirugía General. Internado Rotatorio en el Merey Hospital Davenport, lowa, 1939-1940. Se matriculó en un Curso de Cirugía General en el Cook County Graduate School of Medicine, 1939-1941 Yen la Mayo Clinic de Rochester, Minnesota. Asistió además al Columbus Hospital de New York y al Charity Hospital de New Orleans...

Estudo das condições de saúde das crianças do Município de São Paulo, SP (Brasil, 1984/1985: X - Consumo Alimentar A study of children's health in S. Paulo City (Brazil, 1984-1985: X - Food intake

Directory of Open Access Journals (Sweden)

Sophia Cornbluth Szarfarc

1988-08-01

Full Text Available Como parte de amplo estudo epidemiológico sobre condições de saúde na infância, uma amostra probabilística de menores de cinco anos residentes no Município de São Paulo (n = 305 foi estudada com relação à adequação nutricional de suas dietas. Através do inquérito recordatorio do consumo alimentar nas últimas 24 horas evidenciou-se que: a a partir de um ano de idade, as dietas tornam-se insuficientes para cobrir as necessidades energéticas de grande parte da população; b em todas as idades, mas particularmente nos primeiros dois anos de vida, o aporte dietético de ferro está muito abaixo das quantidades recomendadas para o consumo do nutriente; c em todas as idades, o aporte de proteína e de vitamina A alcança valores satisfatórios. Tais achados mostraram-se compatíveis com a avaliação clínico-laboratorial do estado nutricional realizada simultaneamente ao inquérito alimentar. A estratificação social da amostra revelou que o nível sócio-econômico familiar influencia fortemente o consumo energético e, de forma menos intensa, o consumo de ferro. Na discussão dos prováveis fatores responsáveis pelos déficits dietéticos encontrados, hipóteses distintas são aventadas para o déficit energético e para o déficit de ferro. No caso do déficit energético, a origem básica do problema pareceria residir no baixo poder aquisitivo da população que condiciona insuficiente disponibilidade de alimentos e ingestão quantitativamente deficiente. No caso do déficit de ferro, a mesma hipótese valeria inteiramente apenas a partir da idade de dois anos. Antes desta idade, fatores relacionados ao desmame precoce e ao atraso na introdução de alimentos ricos em ferro aparentemente seriam mais importantes.As part of a broad epidemiological survey of the health conditions of under-fives, a random sample (n = 305 of children living in S. Paulo city (Brazil was submitted to a 24-hour dietary recall. The main results were: a

BEOLCHINI, Valeria y PAVÓN RAMÍREZ, Marta. Dentro del archivo secreto del Vaticano. Guía para la investigación a partir de documentos sobre el País Vasco. Época Medieval (1198-1458). Vizcaya: Servicio Editorial de la Universidad del País Vasco, 2014. 91 págs. [17 x 24].

OpenAIRE

Rodríguez Segura, Joan

2015-01-01

"Con más de 85 kilómetros lineales de estantería, más de 650 fondos archivísticos y un arco cronológico que cubre más de doce siglos son, en efecto, unos números que abruman". Con esta afirmación Cristina Jular Pérez-Alfaro, inicia la presentación de este pequeño libro.

Bridging the gap between education and appropriate use of benzodiazepines in psychiatric clinical practice

Directory of Open Access Journals (Sweden)

Dell’Osso B

2015-07-01

Full Text Available Bernardo Dell’Osso,1,2,* Umberto Albert,3,* Anna Rita Atti,4 Claudia Carmassi,5 Giuseppe Carrà,6 Fiammetta Cosci,7 Valeria Del Vecchio,8 Marco Di Nicola,9 Silvia Ferrari,10 Arianna Goracci,11 Felice Iasevoli,12 Mario Luciano,8 Giovanni Martinotti,13 Maria Giulia Nanni,14 Alessandra Nivoli,15,16 Federica Pinna,17 Nicola Poloni,18 Maurizio Pompili,19 Gaia Sampogna,8 Ilaria Tarricone,20 Sarah Tosato,21 Umberto Volpe,8 Andrea Fiorillo8 1Department of Psychiatry, University of Milan, Fondazione IRCCS Ca’ Granda, Ospedale Maggiore Policlinico, Milan, Italy; 2Bipolar Disorders Clinic, Stanford Medical School, Stanford University, CA, USA; 3Rita Levi Montalcini Department of Neuroscience, University of Turin, Torino, 4Department of Biomedical and NeuroMotor Sciences, University of Bologna, Bologna, 5Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy; 6Division of Psychiatry, Faculty of Brain Sciences, University College London, London, UK; 7Department of Health Sciences, University of Florence, Florence, 8Department of Psychiatry, University of Naples SUN, Naples, 9Institute of Psychiatry and Psychology, Catholic University of Sacred Heart, Rome, 10Department of Diagnostic-Clinical Medicine and Public Health, University of Modena and Reggio Emilia, Modena, 11Department of Molecular Medicine and Clinical Department of Mental Health, University of Siena, Siena, 12Department of Neuroscience, Reproductive Sciences and Odontostomatology, University Federico II of Naples, Naples, 13Department of Neuroscience, Imaging, and Clinical Science, University G.d Annunzio, Chieti-Pescara, 14Section of Psychiatry, Department of Biomedical and Specialty Surgical Sciences, University of Ferrara, Ferrara, 15Psychiatric Institute, Department of Clinical and Experimental Medicine, University of Sassari, Sassari, Italy; 16Bipolar Disorder Unit, CIBERSAM, IDIBAPS, Hospital Clinic, University of Barcelona, Barcelona, Spain; 17Department of

Magnetism reflectometer study shows LiF layers improve efficiency in spin valve devices

Energy Technology Data Exchange (ETDEWEB)

Bardoel, Agatha A [ORNL; Lauter, Valeria [ORNL; Szulczewski, Greg J [ORNL

2012-01-01

New, more efficient materials for spin valves - a device used in magnetic sensors, random access memories, and hard disk drives - may be on the way based on research using the magnetism reflectometer at Oak Ridge National Laboratory (ORNL). Spin valve devices work by means of two or more conducting magnetic material layers that alternate their electrical resistance depending on the layers alignment. Giant magnetoresistance is a quantum mechanical effect first observed in thin film structures about 20 years ago. The effect is observed as a significant change in electrical resistance, depending on whether the magnetization of adjacent ferromagnetic layers is in a parallel or an antiparallel magnetic alignment. 'What we are doing here is developing new materials. The search for new materials suitable for injecting and transferring carriers with a preferential spin orientation is most important for the development of spintronics,' said Valeria Lauter, lead instrument scientist on the magnetism reflectometer at the Spallation Neutron Source (SNS), who collaborated on the experiment. The researchers discovered that the conductivity of such materials is improved when an organic polymer semiconductor layer is placed between the magnetic materials. Organic semiconductors are now the material of choice for future spin valve devices because they preserve spin coherence over longer times and distances than conventional semiconductors. While research into spin valves has been ongoing, research into organic semiconductors is recent. Previous research has shown that a 'conductivity mismatch' exists in spin valve systems in which ferromagnetic metal electrodes interface with such organic semiconductors as Alq3 ({pi}-conjugated molecule tris(8-hydroxy-quinoline) aluminium). This mismatch limits the efficient injection of the electrons from the electrodes at the interface with the semiconductor material. However, lithium fluoride (LiF), commonly used in light

5th National Congress of the Italian Society of Physiotherapy

Directory of Open Access Journals (Sweden)

Alessandro Aina

2016-10-01

, Aina Alessandro P3 Hamstring injuries: clinical assessment or image evaluation? Bonfanti M., Pasquetti M. P4 Effectiveness of the physical therapy treatment on pelvic floor muscles in pelvic girdle pain. A literature review Bortolami Arianna, Pillastrini Paolo, Vanti Carla P5 Scapulo-humeral muscles electromiographic activity during the elevation movement of the upper limb in subjects with rotator cuff lesion Brioschi D, Vitali M, Pedretti A, Fraschini G, Tettamanti A P6 Mechanical low back pain: secular trend and intervention topics of randomized controlled trials Castellini G, Gianola S, Bonovas S, Banfi G, Moja L P7 Quality of reporting in rehabilitation interventions for low back pain: a review of published randomised controlled trials Greta Castellini, Silvia Gianola, Pamela Frigerio, Michela Agostini, Rosa Bolotta, Davide Corbetta, Monica Gasparini, Paolo Gozzer, Erica Guariento, Linda Li, Valentina Pecoraro, Valeria Sirtori, Andrea Turolla, Andreano A, Lorenzo Moja P8 Power analysis and sample size reporting in rehabilitation of low back pain: review of randomized controlled trials included in Cochrane systematic review Castellini G, Gianola S, Bonovas S, Moja L P9 A core outcome set for clinical trials in non-specific low back pain Alessandro Chiarotto, Caroline B. Terwee, Maarten Boers, Raymond W. Ostelo P10 Roland & Morris Disability Questionnaire and Oswestry Disability Index: which has better measurement properties? A systematic review and meta-analysis Alessandro Chiarotto, Lara J. Maxwell, Caroline B. Terwee, George A. Wells, Peter Tugwell, Raymond W. Ostelo P11 Prevalence of myofascial trigger points in spinal pain disorders: systematic review and meta-analysis Alessandro Chiarotto, Ron Clijsen, Cesar Fernandez-de-las-Penas, Marco Barbero P12 Post-surgical scar rating scales in physiotherapy: a systematic review Ciceri Matteo, Rossetti Sara, Vercelli Stefano P13 Efficacy of action observation pre-operative training in functional recovery after hip and

EMRS Spring Meeting 2014 Symposium D: Phonons and fluctuations in low dimensional structures

International Nuclear Information System (INIS)

2014-01-01

on 8th and 9th September 2011, attended by 55 researchers and (4) the 3rd Workshop on Phonons and Fluctuations, held in Saint Feliux de Guixols (Girona, Spain) during 21 to 24th May 2012 attended by 65 participants from Europe and the USA. These papers in this proceeding are examples of the work presented at the symposium. They represent the tip of the iceberg, as the symposium attracted over 100 abstracts. The meeting room was usually full with an audience varying between 40 and 100 participants. The plenary presentation was given by Prof. Gang Chen (MIT) on ''Ballistic and Coherent Phonon Heat Conduction in Bulk Materials and Nanostructures'', which was warmly welcome by an eager and highly motivated audience. The invited speakers were: Prof. Thomas Dehoux (U. Bordeaux), Dr S. Chung (U. New South Wales, Australia), Prof. A. Goni (CSIC-ICMAB), Prof. Giuliano Benenti (U. Insubria), Dr. Davide Donadio (Max Planck Institute for Polymer Research, Mainz), Prof. George Fytas (University of Crete), Prof. Dr. Tobias Kippenberg (EPFL, Switzerland), Prof. Bernard Perrin (INSP, Paris), Prof. Gyaneshwar P. Srivastava, U. Exeter) and Prof. Dr. Achim Kittel (U. Oldenburg). The organisers are very grateful to them for supporting the symposium and sharing their latest research results with the symposium participants. The symposium organisers recognised the participation of students and awarded prizes to the two Best Student Presentations, which went to Valeria Lacatena (IEMN, Lille) with an invited presentation entitled ''Efficient reduction of thermal conductivity in silicon using phononic-engineered membranes'' and to Yan Qing Liu (Institute Neel, Grenoble) who presented the talk entitled ''Sensitive 3-omega measurements of epitaxial thermoelectric thin films''. The poster session had about fifty posters and the four best poster prizes went to: Konstanze Hahn et al. (U. Cagliari) poster title ''Determination of

EMRS Spring Meeting 2014 Symposium D: Phonons and fluctuations in low dimensional structures

Science.gov (United States)

2014-11-01

September 2011, attended by 55 researchers and (4) the 3rd Workshop on Phonons & Fluctuations, held in Saint Feliux de Guixols (Girona, Spain) during 21 to 24th May 2012 attended by 65 participants from Europe and the USA. These papers in this proceeding are examples of the work presented at the symposium. They represent the tip of the iceberg, as the symposium attracted over 100 abstracts. The meeting room was usually full with an audience varying between 40 and 100 participants. The plenary presentation was given by Prof. Gang Chen (MIT) on ''Ballistic and Coherent Phonon Heat Conduction in Bulk Materials and Nanostructures'', which was warmly welcome by an eager and highly motivated audience. The invited speakers were: Prof. Thomas Dehoux (U. Bordeaux), Dr S. Chung (U. New South Wales, Australia), Prof. A. Goni (CSIC-ICMAB), Prof. Giuliano Benenti (U. Insubria), Dr. Davide Donadio (Max Planck Institute for Polymer Research, Mainz), Prof. George Fytas (University of Crete), Prof. Dr. Tobias Kippenberg (EPFL, Switzerland), Prof. Bernard Perrin (INSP, Paris), Prof. Gyaneshwar P. Srivastava, U. Exeter) and Prof. Dr. Achim Kittel (U. Oldenburg). The organisers are very grateful to them for supporting the symposium and sharing their latest research results with the symposium participants. The symposium organisers recognised the participation of students and awarded prizes to the two Best Student Presentations, which went to Valeria Lacatena (IEMN, Lille) with an invited presentation entitled ''Efficient reduction of thermal conductivity in silicon using phononic-engineered membranes'' and to Yan Qing Liu (Institute Neel, Grenoble) who presented the talk entitled ''Sensitive 3-omega measurements of epitaxial thermoelectric thin films''. The poster session had about fifty posters and the four best poster prizes went to: Konstanze Hahn et al. (U. Cagliari) poster title ''Determination of Thermal conductivity in (nanostructured) SiGe materials'', Florian Doehring et al. (U

PREFACE: The Eighth Liquid Matter Conference The Eighth Liquid Matter Conference

Science.gov (United States)

Dellago, Christoph; Kahl, Gerhard; Likos, Christos N.

2012-07-01

interface tension of flat and curved interfaces from Monte Carlo simulationsA Tröster and K Binder Phase diagrams of particles with dissimilar patches: X-junctions and Y-junctionsJ M Tavares and P I C Teixeira The unbearable heaviness of colloids: facts, surprises, and puzzles in sedimentationRoberto Piazza, Stefano Buzzaccaro and Eleonora Secchi Exploring water and other liquids at negative pressureFrédéric Caupin, Arnaud Arvengas, Kristina Davitt, Mouna El Mekki Azouzi, Kirill I Shmulovich, Claire Ramboz, David A Sessoms and Abraham D Stroock The configurational space of colloidal patchy polymers with heterogeneous sequencesIvan Coluzza and Christoph Dellago Repeated sorption of water in SBA-15 investigated by means of in situ small-angle x-ray scatteringM Erko, D Wallacher, G H Findenegg and O Paris Transition of the hydration state of a surfactant accompanying structural transitions of self-assembled aggregatesM Hishida and K Tanaka The effects of topology on the structural, dynamic and mechanical properties of network-forming materialsMark Wilson Surface tension of an electrolyte-air interface: a Monte Carlo studyAlexandre Diehl, Alexandre P dos Santos and Yan Levin Water and other tetrahedral liquids: order, anomalies and solvationB Shadrack Jabes, Divya Nayar, Debdas Dhabal, Valeria Molinero and Charusita Chakravarty Diffusion coefficient and shear viscosity of rigid water modelsSami Tazi, Alexandru Boţan, Mathieu Salanne, Virginie Marry, Pierre Turq and Benjamin Rotenberg Phase behaviour of colloidal assemblies on 2D corrugated substratesSamir El Shawish, Emmanuel Trizac and Jure Dobnikar Structural properties of dendrimer-colloid mixturesDominic A Lenz, Ronald Blaak and Christos N Likos Fluid-fluid demixing of off-critical colloid-polymer systems confined between parallel platesE A G Jamie, R P A Dullens and D G A L Aarts Simulations of nematic homopolymer melts using particle-based models with interactions expressed through collective variablesKostas Ch

Discurso de Orden Pronunciado por el Dr. Carlos Sanmartín

Directory of Open Access Journals (Sweden)

Carlos Sanmartín

1992-12-01

el centenario del nacimiento de tan ilustre colombiano.

En el libro de bautismos No. 15, folio 56, de la pequeña población de Iza, sita en el Valle de Sogamoso, dice: “En Iza, a veintinueve de noviembre de 1891, bauticé solemnemente a un niño de cuatro días de nacido a quien llamé Luis Benigno, hijo legítimo de Timoteo Patiño y Mercedes Camargo; abuelos paternos Domingo (Patiño y Valeria Ramos; maternos, Remigio (Camargo y Bárbara Bayona. Fueron padrinos Telésforo Bayona y Domitila Fonseca, a quienes advertí lo necesario. Doy fe Rubén Salcedo”.

Su niñez transcurrió en Iza y allí, en la escuela pública y en el Colegio de Pesca hizo los estudios de primaria. Los de secundaria los inició en el Colegio Sugamuxi de Sogamoso y los terminó en el Colegio Mayor de Nuestra Señora del Rosario de Bogotá; este Colegio y su rector, Monseñor Rafael María Carrasquilla, tuvieron gran influencia sobre Luis Patiño. En 1914 recibió su diploma de Bachiller y fue elegido para la honrosa posición de Colegial de Número de ese centro docente.

Siempre estuvo orgulloso de haberse formado en esos claustros y siempre recordó con respeto, afecto y gratitud a Monseñor Carrasquilla; estos sentimientos los expresó bellamente en repetidas ocasiones, por ejemplo, en su tesis de grado de 1922, a la cual me referiré más adelante, y en el discurso que pronunció en 1968 cuando ingresó a la Academia Colombiana de la Lengua tratando doctamente el tema del léxico médico.

Relatar y comentar en una ocasión como esta que hoy nos congrega la vida, las múltiples actividades, las muchas realizaciones de Luis Patiño Camargo y las numerosas distinciones que recibió y todo lo que sobre él se ha escrito, sería tarea de varias horas. Existe un gran caudal de información al respecto, gracias al escrupuloso cuidado con que él conservaba correspondencia, documentos, publicaciones, etc., ya la excelente labor de recopilación y ordenamiento, que con

Properties of the ZrO2MgO/MgZrO3NiCr/NiCr triple-layer thermal barrier coating deposited by the atmospheric plasma spray process / Характеристики трехслойных термобарьерных покрытий ZrO2MgO/ MgZrO3NiCr/ NiCr, нанесенных воздушно-плазменным напылением / Svojstva troslojne termo barijerne prevlake ZrO2MgO/ MgZrO3NiCr/ NiCr deponovane atmosferskim plazma sprej procesom

Directory of Open Access Journals (Sweden)

Mihailo R. Mrdak

2016-04-01

. Radi dobijanja strukturnih i mehaničkih osobina slojeva, koji će obezbediti dobru toplotnu i abrazivnu zaštitu zadnjim krilima aviona J-22 pri ispaljivanju raketa munje i groma, izvršena je depozicija tri tipa praha na substratima od legure Al debljine 0,6 mm. Ova studija opisuje postupak korišćenja troslojne TBC prevlake kao izbor dobre kombinacije od mnogo raspoloživih mogućnosti, koja predstavlja kompromis između toplotne zaštite i otpornosti na abraziju za zaštitu zadnjih krila aviona. Studija se, uglavnom, zasniva na eksperimentalnom pristupu. Procena mehaničkih osobina slojeva urađena je ispitivanjem mikrotvrdoće metodom HV0.3 i čvrstoće spoja ispitivanjem na zatezanje. Struktura slojeva ispitana je metodom svetlosne mikroskopije i površina ZrO2MgO keramičkih slojeva metodom skenirajuće elektronske mikroskopije (SEM. Toplotna zaštita TBC slojeva i otpornost na abraziju ispitana je u tunelu Vojnotehničkog instituta iz Žarkova. Na osnovu dobijenih karakteristika površinskih slojeva i simuliranja ispaljivanja rakete, troslojni sistem TBC prevlake pokazao se pouzdanim.

List of Participants

Science.gov (United States)

2008-11-01

MoralIstituto Nazionale di Fisica Nucleare, Università di Torino Valentina Giangreco Marotta PulettiUppsala University Valeria L GiliQueen Mary, University of London Luciano GirardelloUniversità di Milano-Bicocca Gian GiudiceCERN, Geneva Kevin Goldstein Institute for Theoretical Physics, Utrecht University Joaquim Gomis Universitat de Barcelona Pietro Antonio GrassiUniversità del Piemonte Orientale, Alessandria Viviane GraßLudwig-Maximilians-Universität, München Gianluca Grignani Università di Perugia Luca Griguolo Università di Parma Johannes GrosseJagiellonian University, Krakow Umut Gursoy École Polytechnique, Palaiseau Norberto Gutierrez RodriguezUniversity of Oviedo Babak HaghighatPhysikalisches Institut, Universität Bonn Troels Harmark Niels Bohr Institute, København Robert HaslhoferEidgenössische Technische Hochschule (ETH), Zürich Tae-Won HaPhysikalisches Institut, Universität Bonn Alexander HauptImperial College London and Max-Planck-Institut für Gravitationsphysik (AEI), Potsdam Marc HenneauxUniversité Libre de Bruxelles Johannes HennLAPTH, Annecy-le-Vieux Shinji HiranoNiels Bohr Institute, København Stefan HoheneggerEidgenössische Technische Hochschule (ETH), Zürich Jan HomannLudwig-Maximilians-Universität, München Gabriele Honecker CERN, Geneva Joost HoogeveenInstituut voor Theoretische Fysica, Universiteit van Amsterdam Mechthild HuebscherUniversidad Autónoma de Madrid Chris HullImperial College London Carmen-Liliana IonescuUniversity of Craiova Ella JasminUniversité Libre de Bruxelles Konstantin KanishchevInstitute of Theoretical Physics, University of Warsaw Stefanos Katmadas Utrecht University Alexandros KehagiasNational Technical University of Athens Christoph Keller Eidgenössische Technische Hochschule (ETH), Zürich Patrick Kerner Max-Planck-Institut für Physik, München Rebiai KhaledLaboratoire de Physique Mathématique et Physique Subatomique, Université Mentouri, Constantine Elias Kiritsis Centre de Physique Théorique, �

Editorial

Directory of Open Access Journals (Sweden)

Eloisa Bordoli, Dra.

2017-12-01

��, ofrece los principales hallazgos de un estudio cualitativo realizado a estudiantes del Plan de Formación Profesional Básica. En este se analizan los sentidos educativos que construyen los estudiantes a lo largo del curso así como la posibilidad de intervenir en la construcción de estos. Desde una comprensión mutuamente configurante entre el orden estructural y subjetivo de los sentidos la autora identifica aquellos históricos que se relacionan con los mandatos sociales e institucionales, los emergentes que se articulan con las singularidades de los recorridos y los móviles. Estos últimos dan cuenta del carácter no fijo del interés así como de la posibilidad que los docentes -y la relación pedagógica que se configura en la enseñanza -tienen en los procesos de alteración de los sentidos. Por su parte, el artículo de Valeria Píriz, “El vínculo educativo y los procesos de ligazón en educación media básica: las voces de docentes y estudiantes. Estudio exploratorio en dos liceos públicos de Montevideo”, articula aportes del psicoanálisis y de la pedagogía para analizar los procesos de configuración del vínculo educativo. Desde este ángulo analítico identifica el lugar que tienen los fenómenos transferenciales en este vínculo educativo. Estos procesos incidirían - dificultando o facilitando - en el encuentro entre el deseo de enseñar del docente y el deseo de aprender de los educandos. Desde este abordaje, el vínculo y los procesos transferenciales se ubican en un lugar neurálgico para que el educando acepte la plaza que la enseñanza le ofrece y asuma el lugar de sujeto de la educación.   El artículo de Clarisa Flous, “Discursos en políticas y programas de inclusión educativa en la enseñanza media básica en Uruguay (2005‑2012”, analiza la construcción de los discursos de las políticas y programas de inclusión educativa en enseñanza media básica en Uruguay. En él se efectúa una interesante discusión en torno al concepto