Laval nozzles for cluster-jet targets

Energy Technology Data Exchange (ETDEWEB)

Grieser, Silke; Bonaventura, Daniel; Hergemoeller, Ann-Katrin; Hetz, Benjamin; Koehler, Esperanza; Lessmann, Lukas; Khoukaz, Alfons [Institut fuer Kernphysik, Westfaelische Wilhelms-Universitaet Muenster, 48149 Muenster (Germany)

2016-07-01

Cluster-jet targets are highly suited for storage ring experiments due to the fact that they provide high and constant beam densities. Therefore, a cluster-jet target is planned to be the first internal target for the PANDA experiment at FAIR. A cluster source generates a continuous flow of cryogenic solid clusters by the expansion of pre-cooled gases within fine Laval nozzles. For the production of clusters the geometry of the nozzle is crucial. The production of such nozzles with their complex inner geometry represents a major technical challenge. The possibility to produce new fine Laval nozzles ensures the operation of cluster-jet targets, e.g. for the PANDA experiment, and opens the way for future investigations on the cluster production process to match the required targets performance. Optimizations on the recently developed production process and the fabrication of new glass nozzles were done. Initial measurements of these nozzles at the PANDA cluster-jet target prototype and the investigation of the cluster beam origin within the nozzle will be presented and discussed. For the future more Laval nozzles with different geometries will be produced and additional measurements with these new nozzles at the PANDA cluster-jet target prototype towards higher performance will be realized.

"New Yorgi lood" filmioperaatorite pilguga / Sven Nykvist ; tõlkinud Krista Lill

Index Scriptorium Estoniae

Nykvist, Sven, 1922-2006

1990-01-01

Operaatorid Sven Nykvist, Vittorio Storaro ja Nestor Almendros oma koostööst režissööride Woody Alleni, Martin Scorsese ja Francis Ford Coppolaga - "New Yorgi lood" (1989), lüh. tõlge ajakirjast "American Cinematographer", 1989, nr. 3. Sissejuhatus Ago Ruusilt

Muusikamaailm : Rahvusvahelised festivalid juunis. New Yorgi Filharmoonikud Euroopas. Suri Oskar Czerwenka / Priit Kuusk

Index Scriptorium Estoniae

Kuusk, Priit, 1938-

2000-01-01

Rahvusvahelistest festivalidest juunis : Aldeburghi festivalist Inglismaal, Salzburg Whitsun Baroque Festivalist, Bathi festivalist, Spoleto festivalist Charlestonis USAs, San Francisco festivalist. New Yorgi Filharmoonikute Euroopa-turneest. Lühidalt O. Czerwenka tegevusest

Uudised : Mika Salo ja Leningrad Cowboys filmisid rockvideot. Erkki-Sven Tüüri autorikontsert moodsate klassikute sarjas. Minimalistlik "Katja Kabanova" Amsterdami ooperis

Index Scriptorium Estoniae

2000-01-01

M. Salo ja ans. Leningrad Cowboys salvestasid Helsingis muusikavideot, M. Salo osaleb kitarristina ansambli plaadil "Terzo Mondo". 12. mail andis Absolute Ensemble K. Järvi juhatusel New Yorgis sarja "Heliloojate portreed" raames kontserdi E.-S. Tüüri loomingust. Nederlandse Operas tuli lavale L. Janaceki ekspressiivne ooper "Katja Kabanova", lavastusest

Broadway teatrites näeb Denzel Washingtoni ja Catherine Zeta-Jonesi / Andres Laasik

Index Scriptorium Estoniae

Laasik, Andres, 1960-2016

2010-01-01

New Yorgis välja antud Tony teatriauhinna pälvisid filminäitlejad Denzel Washington, Catherine Zeta-Jones ja Scarlett Johansson. Parim lavale naasnud näidend - "Piirdeaed", parim uus näidend - draama "Punane", mis räägib läti päritolu maalikunstnikust Mark Rothkost. Parim muusikal - "Memphis"

Hugo Bossi kunstiauhind / Maria-Kristiina Soomre

Index Scriptorium Estoniae

Soomre, Maria-Kristiina, 1978-

2002-01-01

Guggenheimi muuseum New Yorgis annab 2002. a. sügisel taas välja Hugo Bossi kunstiauhinna: 50000 dollarit ja isiknäitus Guggenheimis 2003. a. alguses. Kandidaadid: Francis Alys, Olafur Eliasson, Hachiya Kazuhiko, Koo Jeong-a, Pierre Huyghe, Anri Sala

Percutaneous drainage of Morel-Lavallée lesions when the diagnosis is delayed.

Science.gov (United States)

Zhong, Biao; Zhang, Chi; Luo, Cong-feng

2014-10-01

Morel-Lavallée lesions are a closed internal degloving, and open débridement can damage the only remaining blood supply to the skin. We performed percutaneous draining and débridement to treat 8 patients in whom the diagnosis of Morel-Lavallée lesions was delayed more than 1 week. Here we discuss our treatment procedures and the outcomes in these 8 patients. We consider percutaneous drainage to be an effective treatment for patients with delayed diagnosis of Morel-Lavallée lesions.

Kolm õde Eestist Londoni laval / Andres Laasik

Index Scriptorium Estoniae

Laasik, Andres, 1960-2016

1999-01-01

Inglise näitleja Steven Dykesi näidend "Kolonistid" Londoni Bridge Lane Theatre laval. Näidend on inspireeritud A. Tshehhovi "Kolmest õest" ja tegevus toimub Eestis, tegelased on siinsed venelased

Black hole acoustics in the minimal geometric deformation of a de Laval nozzle

Energy Technology Data Exchange (ETDEWEB)

Rocha, Roldao da [Universidade Federal do ABC-UFABC, Centro de Matematica, Computacao e Cognicao, Santo Andre (Brazil)

2017-05-15

The correspondence between sound waves, in a de Laval propelling nozzle, and quasinormal modes emitted by brane-world black holes deformed by a 5D bulk Weyl fluid are here explored and scrutinized. The analysis of sound waves patterns in a de Laval nozzle in the laboratory, reciprocally, is here shown to provide relevant data about the 5D bulk Weyl fluid and its on-brane projection, comprised by the minimal geometrically deformed compact stellar distribution on the brane. Acoustic perturbations of the gas fluid flow in the de Laval nozzle are proved to coincide with the quasinormal modes of black holes solutions deformed by the 5D Weyl fluid, in the geometric deformation procedure. Hence, in a phenomenological Eoetvoes-Friedmann fluid brane-world model, the realistic shape of a de Laval nozzle is derived and its consequences studied. (orig.)

Sacral morel-lavallée lesion: a not-so-rare diagnosis.

Science.gov (United States)

Tresley, Jonathan; Jose, Jean; Saraf-Lavi, Efrat; Sklar, Evelyn

2014-12-01

Morel-Lavallée lesions are closed soft tissue degloving injuries with a propensity to become infected, arising in the lumbosacral region or even the scalp, common anatomical locations in neuroradiological studies. The radiologist must recognize this entity, its traumatic etiology, and treatment options. Our patient's Morel-Lavallée lesion was evaluated with ultrasound and MRI, demonstrating a predominantly hemorrhagic lesion successfully managed by aspiration.

Tappev kuulsus viib Chicago lavale / Andres Laasik

Index Scriptorium Estoniae

Laasik, Andres, 1960-2016

2003-01-01

Muusikafilm "Chicago", mille aluseks John Kanderi - Fred Ebb'i muusikal : režissöör Rob Marshall : Ameerika Ühendriigid 2002. 1975.a. selle muusikali Broadwayl lavale toonud Bob Fosse mõjust filmi stiilile

Management of the Morel-Lavallée Lesion.

Science.gov (United States)

Greenhill, Dustin; Haydel, Christopher; Rehman, Saqib

2016-01-01

Morel-Lavallée lesions are closed degloving injuries sustained during violent soft tissue shear that separate the subdermal fat from its strong underlying fascia. Lesions most often occur in the peritrochanteric region, and patients may have concomitant polytrauma. As a result, a hematoma develops that has a high rate of acute bacterial colonization and chronic recurrence. Conservative treatment outcomes are best for those managed acutely. However, diagnosis is often delayed or missed. Furthermore, there is no universally accepted treatment algorithm. Diagnosis and treatment depend on a surgeon's thorough understanding of the cause, pathophysiology, imaging characteristics, and treatment options of Morel-Lavallée lesions. Copyright © 2016 Elsevier Inc. All rights reserved.

Large Morel-Lavallée lesion presenting as fungating mass with skin ulceration.

Science.gov (United States)

Ryan, Christine E; Wachtel, Sarah; Leef, George; Ozdalga, Errol

2016-01-01

A Morel-Lavallée lesion, a type of soft tissue degloving injury that has also been referred to as a chronic expanding hematoma, is a relatively rare condition that usually develops following traumatic injury. Here, we present a case of a 60-year-old male with a Morel-Lavallée lesion diagnosed over 5 years after a traumatic injury of the hip. He presented with a large fungating mass and overlying skin ulceration, which was highly suspicious for sarcoma. However, lack of other systemic findings and constitutional complaints, as well as negative imaging studies, did not support a diagnosis of malignancy. This information, combined with the history of remote trauma to the affected area, instead led us to suspect the alternative diagnosis of a Morel-Lavallée lesion. The diagnosis was later confirmed by pathology showing a chronic expanding hematoma. To our knowledge, a Morel-Lavallée lesion presenting as a fungating mass has not been previously described.

Uudised : Paavo Järvi ja ERSO. EFK Norras. Vardo Rumessen New Yorgis / Andres Siitan

Index Scriptorium Estoniae

Siitan, Andres, 1963-

2000-01-01

P. Järvi salvestas 8.-15. juunini ERSOga A. Pärdi orkestriteoseid. EFK sõidab 20. juunil kontsertturneele Norrasse, kus antakse 4 kontserti. V. Rumessen esines 4. juunil New Yorgis sooloõhtuga kontserdisarjas "The Pro Piano New York Recital Series 2000"

Chronic Morel-Lavallée Lesion: A Novel Minimally Invasive Method of Treatment.

Science.gov (United States)

Mettu, Ramireddy; Surath, Harsha Vardhan; Chayam, Hanumantha Rao; Surath, Amaranth

2016-11-01

A Morel-Lavallée lesion is a closed internal degloving injury resulting from a shearing force applied to the skin. The etiology of this condition may be motor vehicle accidents, falls, contact sports (ie, football, wrestling),1 and iatrogenic after mammoplasty or abdominal liposuction.2 Common sites of the lesions include the pelvis and/or thigh.3 Isolated Morel-Lavallée lesions without underlying fracture are likely to be missed, which result in chronicity. Management of this condition often requires extensive surgical procedures such as debridement, sclerotherapy, serial percutaneous drainage, negative pressure wound therapy (NPWT), and skin grafting.4,5 The authors wish to highlight a minimally invasive technique for the treatment of chronic Morel-Lavallée lesions.

Kivirähk korraga kahel laval / Tiiu Laks

Index Scriptorium Estoniae

Laks, Tiiu, 1984-

2009-01-01

31. jaan. Ugalas esietenduvast Andrus Kivirähki esimesest näidendist "Vanamehed seitsmendalt" Peeter Tammearu lavastuses ja VAT Teatris lavale jõudvast Kivirähki uusimast tükist "Ingel, ingel, vii mind taeva" Aare Toikka lavastuses

Aare Toikka näidend tuli lavale Budapestis

Index Scriptorium Estoniae

2011-01-01

Budapestis Kolibri teatris esietendus noortelavastus "Help", mille kirjutasid VAT teatri kunstiline juht Aare Toikka ja Ungari lavastja, proosa- ja näitekirjanik Peter Horvath. VAT teatri lavale jõuab "Help" 9. mail, lavastajaiks Margo Teder ja Aare Toikka

All That Swells Is Not A Bruise The Morel-Lavallée Lesion.

Science.gov (United States)

Callahan, Carol L; Eisenman, Justin

2016-01-01

Frequently overlooked, Morel-Lavallée lesions are associated with a closed degloving or shearing mechanism causing a dehiscence of underlying soft tissue with formation of a potential space. This space fills with blood, lymph, and cellular debris, giving the lesion a fluctuant appearance on examination. The potential space associated with larger lesions can be a source for hemorrhage in the appropriate clinical context. However, these lesions are often diagnosed late in their clinical course or are misdiagnosed, leading to long-term complications. Management of this injury typically depends upon the size of the lesion. This article discusses a Morel-Lavallée lesion in an active-duty Servicemember requiring treatment by a plastic surgeon and includes the pathophysiology of Morel-Lavallée lesions, diagnostic strategies, and management pearls. 2016.

Clinics in diagnostic imaging (164). Morel-Lavallée lesion.

Science.gov (United States)

Cheong, Sook Chuei Wendy; Wong, Bak Siew Steven

2016-01-01

A 31-year-old male motorcyclist presented with prepatellar swelling of the left knee after a collision with a car. Magnetic resonance imaging of the knee showed no bony or ligamentous injury to the knee. Instead, a well-defined, thin-walled, T2-weighted hyperintense fluid collection with internal septations was identified in a prefascial location overlying the left patella and patellar tendon. The findings were in keeping with those of a Morel-Lavallée lesion, a closed internal degloving injury. Morel-Lavallée lesions are occasionally encountered after a blunt soft-tissue trauma. The presentation and imaging features are discussed. Copyright © Singapore Medical Association.

Muusikamaailm : Hooaja algus New Yorgis. Beethoveni festival Bonnis. "Praemium Imperiale" laureaadid. Viiuldaja Isaac Stern lahkunud / Priit Kuusk

Index Scriptorium Estoniae

Kuusk, Priit, 1938-

2001-01-01

New Yorgi FO ja Metropolitan Opera hooaja algusest. Festivalist "Internationales Beethovenfest" 21. sept.-9. okt. Bonnis. Jaapani kunstipreemia "Praemium Imperiale" pälvis teiste seas ka O. Coleman. Lühidalt I. Sternist

Morel-Lavallée lesion: A closed degloving injury that requires real attention

International Nuclear Information System (INIS)

Nair, Anirudh V; Nazar, PK; Sekhar, Resmi; Ramachandran, PV; Moorthy, Srikanth

2014-01-01

Morel-Lavallée lesions are post-traumatic, closed degloving injuries occurring deep to subcutaneous plane due to disruption of capillaries resulting in an effusion containing hemolymph and necrotic fat. Magnetic resonance imaging (MRI) is the modality of choice in the evaluation of Morel-Lavallée lesion. Early diagnosis and management is essential as any delay in diagnosis or missed lesion will lead to the effusion becoming infected or leading to extensive skin necrosis

Morel-Lavallée lesion: A closed degloving injury that requires real attention.

Science.gov (United States)

Nair, Anirudh V; Nazar, Pk; Sekhar, Resmi; Ramachandran, Pv; Moorthy, Srikanth

2014-07-01

Morel-Lavallée lesions are post-traumatic, closed degloving injuries occurring deep to subcutaneous plane due to disruption of capillaries resulting in an effusion containing hemolymph and necrotic fat. Magnetic resonance imaging (MRI) is the modality of choice in the evaluation of Morel-Lavallée lesion. Early diagnosis and management is essential as any delay in diagnosis or missed lesion will lead to the effusion becoming infected or leading to extensive skin necrosis.

The Morel-Lavallée Lesion: Diagnosis and Management.

Science.gov (United States)

Scolaro, John A; Chao, Tom; Zamorano, David P

2016-10-01

The Morel-Lavallée lesion is a closed soft-tissue degloving injury commonly associated with high-energy trauma. The thigh, hip, and pelvic region are the most commonly affected locations. Timely identification and management of a Morel-Lavallée lesion is crucial because distracting injuries in the polytraumatized patient can result in a missed or delayed diagnosis. Bacterial colonization of these closed soft-tissue injuries has resulted in their association with high rates of perioperative infection. Recently, MRI has been used to characterize and classify these lesions. Definitive management is dictated by the size, location, and age of the injury and ranges from percutaneous drainage to open débridement and irrigation. Chronic lesions may lead to the development of pseudocysts and contour deformities of the extremity.

Presidendipaar külastas New Yorgi Eesti Kooli / Kärt Ulman ; fotod: Riina Sõrra

Index Scriptorium Estoniae

Ulman, Kärt

2010-01-01

President Toomas Hendrik Ilves ja proua Evelin Ilves külastasid 25. septembril 2010 New Yorgi Eesti Kooli. Õhtusel vastuvõtul kohalikele eestlastele tutvustas president programmi "Talendid koju". Proua Evelin Ilvesel oli võimalus USA presidendi abikaasa Michelle Obama kutsel külastada mahefarmi Stone Barnsis. Töövisiit Ameerika Ühendriikidesse 20.-27.09.2010

Applied Materials taas investorite huviorbiidis / Erlend Zirk

Index Scriptorium Estoniae

Zirk, Erlend

2006-01-01

Ilmunud ka: Delovõje Vedomosti 29. nov. lk. 33. Protsessorite tootmisseadmete tootja Applied Materials on pärast 2000. aasta börsikrahhi taas investorite huviorbiiti jõudmas. Diagramm: Applied Materialsi aktsia

Muusikamaailm : Berliini Filharmoonikud Beethoveniga. Kurtagi festival Gütersloh's. Uus soome ooper. Glyndebourne Opera New Yorgis / Priit Kuusk

Index Scriptorium Estoniae

Kuusk, Priit, 1938-

2001-01-01

Berliini Filharmoonikute Beethoveni festivalist Roomas, Viinis ja Berliinis. Kurtagi festivalist Gütersloh's Saksamaal 16.-18. veebr.Helsingis esietendus 8. veebr. K.Aho kammerooper "Enne kui me kõik oleme hukkunud". Glyndebourne'i Touring Opera tutvustab kuulsa ooperifestivali lavastusi New Yorgis

High-pressure phases of Weyl semimetals NbP, NbAs, TaP, and TaAs

Science.gov (United States)

Guo, ZhaoPeng; Lu, PengChao; Chen, Tong; Wu, JueFei; Sun, Jian; Xing, DingYu

2018-03-01

In this study, we used the crystal structure search method and first-principles calculations to systematically explore the highpressure phase diagrams of the TaAs family (NbP, NbAs, TaP, and TaAs). Our calculation results show that NbAs and TaAs have similar phase diagrams, the same structural phase transition sequence I41 md→ P6¯ m2→ P21/ c→ Pm3¯ m, and slightly different transition pressures. The phase transition sequence of NbP and TaP differs somewhat from that of NbAs and TaAs, in which new structures emerge, such as the Cmcm structure in NbP and the Pmmn structure in TaP. Interestingly, we found that in the electronic structure of the high-pressure phase P6¯ m2-NbAs, there are coexistingWeyl points and triple degenerate points, similar to those found in high-pressure P6¯ m2-TaAs.

Lavale jõuab näitemäng armastuse orjast

Index Scriptorium Estoniae

2007-01-01

Komöödiateatril tuleb lavale Jaan Toominga lavastatud "Venuse armumäng" austria kirjaniku Leopold von Sacher-Masochi romaani "Venus karusnahas" järgi. Osades Veikko Täär, Britta Vahur ja kulturist Imre Vähi

Jõgeval näeb taas kino / Silja Paavle

Index Scriptorium Estoniae

Paavle, Silja, 1976-

2008-01-01

Kultuuriministeeriumi programmi "Kino tuleb tagasi" ja linna enda rahadega on Jõgeva linna kultuurikeskuses taas võimalik kvaliteetselt kino näidata. Vastava esmaklassilise tehnika tõi kohale Music Center OÜ. Osteti see Itaaliast

Kui ise ei tee, siis ei tee keegi : New Yorgi Storefronti galerii-platvormi töökorralduse kogemusi / Anu Lill

Index Scriptorium Estoniae

Lill, Anu

2015-01-01

Artikli autori kogemusi, olnud New Yorgi Storefront for Art and Architecture galeriis turunduse, suhtekorralduse ja arenduse osakonnas praktikal. Storefrontis tehakse näitusi, korraldatakse filmilinastusi, konverentse ning vestlusringe kunstnike ja arhitektidega

Muusikamaailm : Festival Stockholmis. Sada aastat "Finlandiat". Millenniumimuusika New Yorgis. Maazel loobub ametist Münchenis / Priit Kuusk

Index Scriptorium Estoniae

Kuusk, Priit, 1938-

1999-01-01

6.-13. nov. toimub Stockholmis heliloojate festival, mis tutvustab uuemat rootsi ja välismaist muusikat. Soomes tähistatakse 100 aasta möödumist J. Sibeliuse teose "Finlandia" sünnist. New Yorgi Filharmoonikud ja dir. K. Masur esitavad kontserdisarjas "Messages for the Millennium" tellimusteoseid kaasaja heliloojatelt. L. Maazel loobus dirigenditööst

Utilization of Liposuction for Delayed Morel-Lavallée Lesion: A Case Report and Review.

Science.gov (United States)

Gardner, Preston; Flis, Diana; Chaiyasate, Kongkrit

2017-01-01

Morel-Lavallée lesions are irregularly occurring and often overlooked results of traumatic injuries, resulting in potential long-term encapsulation of fluid between soft-tissue layers. The objective in this review was to discuss the delayed presentation of a Morel-Lavallée lesion and operative utility of liposuction in the patient's treatment and review literature with particular focus on diagnosis and therapeutic interventions. The reviewed case demonstrates the presentation and successful therapy of a young female presenting with a MLL and contour deformity.

Anomalous electronic structure and magnetoresistance in TaAs2.

Science.gov (United States)

Luo, Yongkang; McDonald, R D; Rosa, P F S; Scott, B; Wakeham, N; Ghimire, N J; Bauer, E D; Thompson, J D; Ronning, F

2016-06-07

The change in resistance of a material in a magnetic field reflects its electronic state. In metals with weakly- or non-interacting electrons, the resistance typically increases upon the application of a magnetic field. In contrast, negative magnetoresistance may appear under some circumstances, e.g., in metals with anisotropic Fermi surfaces or with spin-disorder scattering and semimetals with Dirac or Weyl electronic structures. Here we show that the non-magnetic semimetal TaAs2 possesses a very large negative magnetoresistance, with an unknown scattering mechanism. Density functional calculations find that TaAs2 is a new topological semimetal [ℤ2 invariant (0;111)] without Dirac dispersion, demonstrating that a negative magnetoresistance in non-magnetic semimetals cannot be attributed uniquely to the Adler-Bell-Jackiw chiral anomaly of bulk Dirac/Weyl fermions.

Koread hakkavad taas perekondi kokku lubama / Igor Taro

Index Scriptorium Estoniae

Taro, Igor

2007-01-01

Kahe Korea võimud leppisid kokku, et lähikuudel avaneb jälle võimalus taasühineda peredel, kes jäid Korea sõja tagajärjel aastakümneteks kahele poole piiri. Põhja- ja Lõuna-Korea vahelise konflikti lühiülevaade

Morel-Lavallée lesion: diagnosis and treatment with imaging techniques.

Science.gov (United States)

Martel Villagrán, J; Díaz Candamio, M J; Bueno Horcajadas, A

We aim to review the characteristics of Morel-Lavallée lesions and to evaluate their treatment. We retrospectively reviewed 17 patients (11 men and 6 women; mean age, 56.1 years, range 25-81 years) diagnosed with Morel-Lavallée lesions in two different departments. All patients underwent ultrasonography, 5 underwent computed tomography, and 9 underwent magnetic resonance imaging. Percutaneous treatment with fine-needle aspiration and/or drainage with a 6F-8F catheter was performed in 13 patients. Two patients required percutaneous sclerosis with doxycycline. All patients responded adequately to percutaneous treatment, although it was necessary to repeat the procedure in 4 patients. Radiologists need to be familiar with this lesion that can be treated percutaneously in the ultrasonography suite when it is not associated with other entities. Copyright © 2018 SERAM. Publicado por Elsevier España, S.L.U. All rights reserved.

[Morel-Lavallée syndrome and post-traumatic nodular fat necrosis: Two post-traumatic complications mimicking cellulitis].

Science.gov (United States)

Moulin, C; Barthélémy, I; Emering, C; D'Incan, M

Dermal and subcutaneous inflammation following direct trauma is initially evocative of soft-tissue infection. However, two differential diagnoses must be considered: Morel-Lavallée syndrome and post-traumatic nodular fat necrosis. Case 1: a 51-year-old woman fell off her motorbike and had dermabrasions on her right and left tibial ridges that rapidly developed into dermo-hypodermitis of the entire limb. There was no improvement after 3 weeks of antibiotics. The patient was apyretic. She had a soft, non-inflammatory tumefaction on the inner aspect of her left knee. Ultrasound revealed subcutaneous collection in both legs. The surgeons confirmed a diagnosis of Morel-Lavallée syndrome and drained the two collections. Progress was good and the patient healed without major consequences. Case 2: following a fall on her stairs, a 40-year-old woman presented dermabrasions and haematomas on her left leg. Antibiotic therapy failed to prevent the progression of dermo-hypodermitis. The patient remained apyretic and there was no inflammatory syndrome. A CT scan showed thickening of a subcutaneous fat and fluid collection, resulting in diagnosis of post-traumatic nodular fat necrosis. Management was surgical and the outcome was good. These two cases show two post-traumatic cutaneous complications: Morel-Lavallée syndrome and post-traumatic nodular fat necrosis. Morel-Lavallée syndrome occurs after tangential trauma next to richly vascularized tissue. Post-traumatic nodular fat necrosis is defined as necrosis of adipocytes. In both cases, diagnosis is confirmed by imagery (Ultrasonography, tomography). Our two case reports show that inflammatory presentation of both Morel-Lavallée syndrome and post-traumatic nodular fat necrosis can lead to diagnostic and therapeutic errors while a surgical procedure is necessary since tissue necrosis can occur. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

TLÜ rektor Rein Raud valiti taas UNICA juhatusse / Maiki Voore

Index Scriptorium Estoniae

Voore, Maiki, 1983-

2009-01-01

Tallinna Ülikooli rektor Rein Raud valiti taas UNICA (Network of Universities from the Capitals of Europe) uue juhatuse liikmeks. UNICA rektorite 2010. aasta seminar otsustati korraldada Tallinna Ülikoolis

Morel-Lavallée Injuries: A Multimodality Approach to Imaging Characteristics.

Science.gov (United States)

Spain, James A; Rheinboldt, Matthew; Parrish, David; Rinker, Eric

2017-02-01

Morel-Lavallée lesions are relatively rare closed degloving injuries caused by a shearing force resulting in separation of the dermis and the hypodermis from the subjacent deeper fascia. Although most commonly encountered lateral to the greater trochanter, these injuries may occur throughout the body in a variety of locations. Separation of the hypodermal tissue planes results in a complex serosanguinous fluid collection with areas of internal fat necrosis. The imaging appearance is variable and nonspecific, potentially mimicking superficial hemorrhagic bursitis, or cystic or necrotic primary soft tissue neoplasms. If not treated in the acute or early subacute setting, these collections are at risk of superinfection, overlying tissue necrosis, and continued expansion. In this article, we will review the pathophysiology, cross-sectional imaging features, and differential diagnostic considerations of Morel-Lavallée lesions as well as discuss management and treatment options. Copyright © 2017 The Association of University Radiologists. Published by Elsevier Inc. All rights reserved.

The Mayo Clinic experience with Morel-Lavallée lesions: establishment of a practice management guideline.

Science.gov (United States)

Nickerson, Terry P; Zielinski, Martin D; Jenkins, Donald H; Schiller, Henry J

2014-02-01

Although uncommon, Morel-Lavallée lesions (also called closed degloving injuries) are associated with considerable morbidity in trauma patients. There is lack of consensus regarding proper management of these lesions. Management options include nonoperative therapies, along with percutaneous and operative techniques. We sought to define the factors associated with failure of percutaneous aspiration to better identify patients requiring immediate operative management. We retrospectively searched our prospectively collected database for patient records containing the terms Morel-Lavallée, closed degloving injury, or posttraumatic seroma from February 2, 2004, through December 23, 2011. Treatment methods included compression wraps or observation (nonoperative management), percutaneous aspiration, or operative management with incision/drainage or formal debridement of skin and soft tissues that resulted in wound vacuum-assisted closure placement and/or split-thickness skin graft (operative management). The treatment groups were compared using univariate analysis and χ testing. We identified 79 patients with 87 Morel-Lavallée lesions in the setting of trauma. Most were caused by motor vehicle collisions (25%). No difference was observed between the treatment groups in sex, body mass index, anticoagulation treatment, diabetes mellitus, smoking history, or alcohol use. The percutaneous aspiration group had higher rates of recurrence (56% vs. 19% and 15% in nonoperative and operative groups, respectively). The percentage of patients who had aspiration of more than 50 mL of fluid was higher for lesions that recurred than for lesions that resolved (83% vs. 33%, p = 0.02). Aspiration of more than 50 mL of fluid from Morel-Lavallée lesions was much more common among lesions that recurred (83%) than among those that resolved (33%). We therefore recommend that aspiration of more than 50 mL of fluid from a Morel-Lavallée lesion prompts operative intervention. We have now

Morel-Lavallée Lesion

Directory of Open Access Journals (Sweden)

Grant G Simpson

2016-09-01

Full Text Available History of present illness: A 17-year-old male presented to the emergency department for significant localized right lower extremity (RLE swelling following a motorcycle traffic accident 12 days prior, causing high-impact blunt trauma to his RLE and included multiple orthopedic fractures on the initial date of injury. Significant findings: On physical examination, he was noted to have a nearly “watermelon-sized” fluctuant mass to his right lateral superior quadriceps with multiple overlying abrasions (Image 1. Computed tomography (CT scans of the area showed a large heterogeneous collection measuring roughly 37×9.5×16 centimeters in the subcutaneous adipose layer of the lateral right thigh (Image 2, while ultrasonography revealed a complex fluid collection containing some nodular solid components and debris (Image 3. Additionally, radiographs confirmed multiple fractures including most significantly a pelvic ring fracture. Surgical debridement, evacuation, and sclerodhesis were performed nine weeks post injury to allow overlying abrasions to heal prior to intervention. Discussion: Morel Lavallée Lesions (MLL are a rare internal degloving injury involving the traumatic separation of the mobile subcutaneous tissue from the immobile underlying fascia, allowing for hemolymph to develop in the closed potential space.1-3 MLL was initially used to refer to regions involving the trochanteric region,1 first reported by Maurice Morel-Lavallée in 1863,4 but now includes various anatomical locations of varying relative incidence2. Clinical manifestations can be inconsistent, though the hallmark physical finding is a soft fluctuant area due to fluid collection,1,3 with motor vehicle collisions comprising the most common mechanism. Onset typically occurs within hours to days, but in up to one third of cases, onset is delayed by up to several months.5 No established standard of care yet exists, but management algorithms have been suggested.2,6 A recent

Alfa-Laval plate heat exchangers for the power industries

International Nuclear Information System (INIS)

Kitae, Junnosuke; Mtsuura, Kazuyuki

1979-01-01

Within power-generating plants, the transfer and conversion of heat energy of very large quantity are carried out in the process of energy conversion, accordingly the importance of heat exchangers is very high. Heretofore, multi-tube heat exchangers have been used mostly, but Alfa-Laval group developed the heat exchanger with very high efficiency to incorporate it effectively into a power-generating plant. In this plate type heat exchanger, the heat transfer efficiency is very high, and the quantity of stagnation is small as it is compact, consequently it is suitable to the secondary cooling for power-generating plant or the heat exchange of high-priced liquid heat media such as heavy water. Originally, plate type heat exchangers were used for food and chemical industries, therefore the prevention of mixing two liquids, sanitary construction, and corrosion resistance were required. Then they were adopted in iron and steel industry, and large thermal load, large heat transfer area and corrosion resistance to sea water were required. They were adopted in a nuclear power plant for the first time in 1964. In this heat exchanger, channels are formed with corrugated metal sheets, and titanium, stainless steels, Incoloy, Hastelloy and others are used as occasion demands. The Alfa-Laval heat exchangers and their features are explained. (Kako, I.)

Collective labour law after Viking, Laval, Rüffert, and Commission v. Luxembourg

NARCIS (Netherlands)

van Peijpe, T.

2009-01-01

The judgments of the European Court of Justice (ECJ) in the International Transport Workers’ Federation and Finnish Seamen’s Union v Viking Line ABP and OÜ Viking Line Eesti (hereinafter ‘Viking’), Laval un Partneri Ltd v Svenska Byggnadsarbetareförbundet and Others (hereinafter ‘Laval’), Dirk

Endoscopic surgical management of a large Morel-Lavallée lesion.

Science.gov (United States)

Walls, Andrew; McMahon, Samuel E; MacDonald, Jonathan; Bunn, Jonathan

2017-09-23

The Morel-Lavallée lesion is a closed degloving injury that usually occurs following high-energy trauma. We present a case demonstrating endoscopic management of this lesion. A 44-year-old man fell from scaffolding. Initial assessment demonstrated no significant injury. An ultrasound scan 2 days post injury revealed a large fluid collection along the lateral right thigh. This subsequently became infected and did not respond to antibiotic therapy.Due to the extent of the lesion, we were reluctant to perform a traditional open drainage. An endoscopic probe was inserted at the proximal and distal poles of the lesion and the wound debrided.This resulted in a rapid improvement in symptoms and a complete resolution of the lesion at 1 year postsurgery, with no wound-associated morbidity.This is only the second description of endoscopic debridement of a large, acute Morel-Lavallée lesion, with an excellent outcome. © BMJ Publishing Group Ltd (unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

Morel-Lavallée Lesion: Presenting Etiology of Chronic Myelogenous Leukemia in an Adolescent Athlete: A Case Report.

Science.gov (United States)

Hadley, Christopher; Wowkanech, Charles; Eck, Brandon; Austin, Luke; Sankar, Wudbhav; Tjoumakaris, Fotios

2016-01-01

A 16-year-old boy presented with a concealed degloving lesion of the knee, a Morel-Lavallée lesion, 3 weeks after an injury to the right knee while playing basketball. An incidental hematologic finding led to the additional diagnosis of chronic myelogenous leukemia. Morel-Lavallée lesions often can be overlooked and appear to be subcutaneous hematomas. This case was complicated further by a leukemic condition that was likely the causative mechanism for the recalcitrant nature of the lesion in this athlete.

Kinnipeetava taasühiskonnastamine Eestis ja Rootsis : [bakalaureusetöö] / Signe Laanemäe ; Tartu Ülikool, õigusteaduskond ; juhendaja: Andres Parmas

Index Scriptorium Estoniae

Laanemäe, Signe

2009-01-01

Vabadusekaotuse olemusest, vangistuse arenguloost, taasühiskonnastamisega seoses esilekerkivatest põhiprobleemidest Eestis ja Rootsis, uutest meetmetest seoses kinnipeetava taasühiskonnastamisega Rootsis

Endine KGB-lane pürib taas Narvas volikokku / Toomas Kümmel

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Kümmel, Toomas

2002-01-01

KGB-mineviku varjamise pärast Keskerakonnast välja visatud Valdek Lans (Vadim Tomilov) astus taas erakonda ja kandideerib kohalikel valimistel. Kommenteerib Narva linnavolikogu esinaine Elsa Suikanen

[One-stage operation for pelvis and acetabular fractures combined with Morel-Lavallée injury by internal fixation associated with vacuum sealing drainage].

Science.gov (United States)

Wei, Dan; Wang, Yue; Yuan, Jiabin; Tang, Xiaoming; Zhang, Bin; Lu, Bing; Tan, Bo

2014-01-01

To investigate the methods and effectiveness of one-stage operation for pelvis and acetabular fractures combined with Morel-Lavallée injury by internal fixation associated with vacuum sealing drainage (VSD). Between June 2008 and October 2012, 15 cases of pelvis and acetabular fractures combined with Morel-Lavallée injury were treated. There were 5 males and 10 females, aged from 18 to 67 years (mean, 36.8 years). Fractures were caused by traffic accident in 11 cases and crashing injury of heavy object in 4 cases. The time from injury to hospitalization was 3 hours to 9 days (mean, 5.4 days). Morel-Lavallée injury located in the above posterior superior iliac spine in 4 cases, greater trochanter in 7 cases, and anterior proximal thigh in 4 cases. In 10 cases complicated by pelvic fracture, there were 1 case of anteroposterior compression type, 3 cases of lateral compression type, 5 cases of vertical shear type, and 1 case of compound injury type; in 5 cases complicated by acetabular fracture, there were 1 case of transverse fracture, 1 case of posterior wall and posterior column fracture, 1 case of transverse acetabulum plus posterior wall fracture, and 2 cases of both columns fracture. Open reduction and internal fixation were used to treat pelvic and acetabular fractures, and VSD to treat Morel-Lavallée injury. When the drainage volume was less than 20 mL/d, interrupted wound suture or free skin grafting was performed. The hospitalization time was 16-31 days (mean, 20.8 days). Thirteen cases were followed up 4-16 months (mean, 7.8 months). The healing time of Morel-Lavallée injury was 16-36 days after operation (mean, 21.3 days). All the wounds had primary healing, and no infection occurred. The X-ray films showed that all fractures healed, with a mean healing time of 13.6 weeks (range, 11-18 weeks). At 6.5 months after operation, according to Majeed function scoring system in 8 cases of pelvic fracture, the results were excellent in 5 cases, good in 2 cases

Hepatoprotective Effects of Panus giganteus (Berk. Corner against Thioacetamide- (TAA- Induced Liver Injury in Rats

Directory of Open Access Journals (Sweden)

Wei-Lun Wong

2012-01-01

Full Text Available Panus giganteus, a culinary and medicinal mushroom consumed by selected indigenous communities in Malaysia, is currently being considered for large scale cultivation. This study was undertaken to investigate the hepatoprotective effects of P. giganteus against thioacetamide- (TAA- induced liver injury in Sprague-Dawley rats. The rats were injected intraperitoneally with TAA thrice weekly and were orally administered freeze-dried fruiting bodies of P. giganteus (0.5 or 1 g/kg daily for two months, while control rats were given vehicle or P. giganteus only. After 60 days, rats administered with P. giganteus showed lower liver body weight ratio, restored levels of serum liver biomarkers and oxidative stress parameters comparable to treatment with the standard drug silymarin. Gross necropsy and histopathological examination further confirmed the hepatoprotective effects of P. giganteus. This is the first report on hepatoprotective effects of P. giganteus. The present study showed that P. giganteus was able to prevent or reduce the severity of TAA-induced liver injury.

Diagnosis and Management of Closed Internal Degloving Injuries: The Morel-Lavallée Lesion.

Science.gov (United States)

Jalota, Leena; Ukaigwe, Anene; Jain, Shashank

2015-07-01

Morel-Lavallée (ML) lesions are closed degloving injuries described as posttraumatic subcutaneous fluid collections. They are most commonly seen in the proximal thigh. They can present several days to months after the inciting event. A 55-year-old woman with a recent admission for trauma presented to the Emergency Department with increasing swelling and pain in the right thigh for the previous 3 days. Ultrasound of the thigh was negative. Magnetic resonance imaging performed to further evaluate for leg swelling revealed a "Morel-Lavallée lesion" of the thigh that required drainage. The patient recovered completely after the surgery. WHY SHOULD THE EMERGENCY PHYSICIAN BE AWARE OF THIS?: Emergency physicians should be aware of these rare lesions because they are often mistaken for tumors or hematomas. Early recognition may avoid subsequent complications and help in obtaining prompt specialist care. Copyright © 2015 Elsevier Inc. All rights reserved.

Järvakandi Klaasi edu tõstab emafirma aktsiat New Yorgi börsil / Annika Matson

Index Scriptorium Estoniae

Matson, Annika, 1976-

2005-01-01

USA kontserni Owens-Illinoisi tütarfirmadest, turuosast, Eesti tütarfirma AS-i Järvakandi Klaas laienemisplaanidest. Diagrammid: Järvakandi Klaas ootab tänavu taas kasumi kasvu; Owens-Illinoisi aktsia on investoritele tulus olnud. Vt. samas: Owens-Illinois on olnud hea aktsia

The laval questionnaire: a new instrument to measure quality of life in morbid obesity.

Science.gov (United States)

Therrien, Fanny; Marceau, Picard; Turgeon, Nathalie; Biron, Simon; Richard, Denis; Lacasse, Yves

2011-08-15

Our recent review of the literature uncovered eleven obesity-specific quality of life questionnaires, all with incomplete demonstration of their measurement properties. Our objective was to validate a new self-administered questionnaire specific to morbid obesity to be used in clinical trials. The study was carried out at the bariatric surgery clinic of Laval Hospital, Quebec City, Canada. This study followed our description of health-related quality of life in morbid obesity from which we constructed the Laval Questionnaire. Its construct validity and responsiveness were tested by comparing the baseline and changes at 1-year follow-up in 6 domain scores (symptoms, activity/mobility, personal hygiene/clothing, emotions, social interactions, sexual life) with those of questionnaires measuring related constructs (SF-36, Impact of Weight on Quality of Life-Lite, Rosenberg Self-Esteem Scale and Beck Depression Inventory-II). 112 patients (67 who got bariatric surgery, 45 who remained on the waiting list during the study period) participated in this study. The analysis of the discriminative function of the questionnaire showed moderate-to-high correlations between the scores in each domain of our instrument and the corresponding questionnaires. The analysis of its evaluative function showed (1) significant differences in score changes between patients with bariatric surgery and those without, and (2) moderate-to-high correlations between the changes in scores in the new instrument and the changes in the corresponding questionnaires. Most of these correlations met the a priori predictions we had made regarding their direction and magnitude. The Laval Questionnaire is a valid measure of health-related quality of life in patients with morbid obesity and is responsive to treatment-induced changes.

Laval askeldavad sümpaatne härra ja sulane, kes polegi rehepapp / Krista Valdvee

Index Scriptorium Estoniae

Valdvee, Krista, 1978-

2009-01-01

Ugala uuest suvelavastusest, Bertolt Brechti rahvatükist "Härra Punttila ja tema sulane Matti", mille kirjutamisel Bertolt Brecht tugines Hella Wuolijoe lugudele. Lavastaja Kalju Komissarov, mängitake Ugala tiigi kõrvale ehitatud laval. Osades: härra Punttila - Peeter Tammearu, Matti - Indrek Sammul

Delayed Presentation of a Chronic Morel-Lavallée Lesion.

Science.gov (United States)

Christian, David; Leland, Hyuma A; Osias, Walter; Eberlin, Seth; Howell, Lori

2016-07-01

Morel-Lavellée lesions are soft tissue degloving injuries resulting from shearing trauma that induces separation of the superficial and deep fascias creating a potential space that becomes filled with hemolymph. Here we present a case of a 28-year-old male presenting with a persistent Type I Morel-Lavallée lesion 2.5 years after an automobile versus pedestrian accident. These lesions can be visualized via computed tomography, plain film and ultrasound, but magnetic resonance imaging is the modality of choice for their identification and characterization.

The laval questionnaire: a new instrument to measure quality of life in morbid obesity

Directory of Open Access Journals (Sweden)

Therrien Fanny

2011-08-01

Full Text Available Abstract Background Our recent review of the literature uncovered eleven obesity-specific quality of life questionnaires, all with incomplete demonstration of their measurement properties. Our objective was to validate a new self-administered questionnaire specific to morbid obesity to be used in clinical trials. The study was carried out at the bariatric surgery clinic of Laval Hospital, Quebec City, Canada. Methods This study followed our description of health-related quality of life in morbid obesity from which we constructed the Laval Questionnaire. Its construct validity and responsiveness were tested by comparing the baseline and changes at 1-year follow-up in 6 domain scores (symptoms, activity/mobility, personal hygiene/clothing, emotions, social interactions, sexual life with those of questionnaires measuring related constructs (SF-36, Impact of Weight on Quality of Life-Lite, Rosenberg Self-Esteem Scale and Beck Depression Inventory-II. Results 112 patients (67 who got bariatric surgery, 45 who remained on the waiting list during the study period participated in this study. The analysis of the discriminative function of the questionnaire showed moderate-to-high correlations between the scores in each domain of our instrument and the corresponding questionnaires. The analysis of its evaluative function showed (1 significant differences in score changes between patients with bariatric surgery and those without, and (2 moderate-to-high correlations between the changes in scores in the new instrument and the changes in the corresponding questionnaires. Most of these correlations met the a priori predictions we had made regarding their direction and magnitude. Conclusion The Laval Questionnaire is a valid measure of health-related quality of life in patients with morbid obesity and is responsive to treatment-induced changes.

Simulation of a flow spontaneously condensed moist steam in Laval nozzles

International Nuclear Information System (INIS)

Avetisyan, A.R.; Alipchenkov, V.M.; Zajchik, L.I.

2002-01-01

The method for simulating the evolution of the drops distribution by size in the course of commonly proceeding processes of nucleation (spontaneous condensation), heterogeneous condensation) evaporation and coagulation is proposed. The results of the analysis of the initial moisture effect on the steam spontaneous condensation in the transonic nozzles are presented. The availability of the minima in the output moisture dependences on the drops initial moisture and size is the most interesting result of the initial moisture effect on the spontaneous condensation in the Laval nozzles [ru

Muusikamaailm : Bremeni festival alanud. Neeme Järvi Festivalil New Yorgis. Sydney ooperimaja juba korrastamisele. Promenaadikontertidel Londonis. Kaks preemiat. Luzernis alustati müütidega / Priit Kuusk

Index Scriptorium Estoniae

Kuusk, Priit, 1938-

1999-01-01

14.08-24.10 toimuvast Bremeni festivalist Saksamaal. N.Järvi juhatas New Yorgi Lincoln Center"i festivalil festivaliorkestrit. Sydney ooperimaja kavandatatavst renoveerimisest. Londonis toimuvatest promenaadikontsertidest. UNESCO ja Rahvusvahelise Muusikanõukogu (IMC) tänavuse preemia laureaatideks valiti E. Nunes ja A. Kuazimov. 14.07-11.09 toimuvast Luzerni muusikafestivalist

Signatures of Fermi Arcs in the Quasiparticle Interferences of the Weyl Semimetals TaAs and NbP.

Science.gov (United States)

Chang, Guoqing; Xu, Su-Yang; Zheng, Hao; Lee, Chi-Cheng; Huang, Shin-Ming; Belopolski, Ilya; Sanchez, Daniel S; Bian, Guang; Alidoust, Nasser; Chang, Tay-Rong; Hsu, Chuang-Han; Jeng, Horng-Tay; Bansil, Arun; Lin, Hsin; Hasan, M Zahid

2016-02-12

The recent discovery of the first Weyl semimetal in TaAs provides the first observation of a Weyl fermion in nature. Such a topological semimetal features a novel type of anomalous surface state, the Fermi arc, which connects a pair of Weyl nodes through the boundary of the crystal. Here, we present theoretical calculations of the quasiparticle interference (QPI) patterns that arise from the surface states including the topological Fermi arcs in the Weyl semimetals TaAs and NbP. Most importantly, we discover that the QPI exhibits termination points that are fingerprints of the Weyl nodes in the interference pattern. Our results, for the first time, propose a universal interference signature of the topological Fermi arcs in TaAs, which is fundamental for scanning tunneling microscope (STM) measurements on this prototypical Weyl semimetal compound. More generally, our work provides critical guideline and methodology for STM studies on new Weyl semimetals. Further, the scattering channels revealed by our QPIs are broadly relevant to surface transport and device applications based on Weyl semimetals.

A Huge Morel-Lavallée Lesion Treated Using a Quilting Suture Method: A Case Report and Review of the Literature.

Science.gov (United States)

Seo, Bommie F; Kang, In Sook; Jeong, Yeon Jin; Moon, Suk Ho

2014-06-01

The Morel-Lavallée lesion is a collection of serous fluid that develops after closed degloving injuries and after surgical procedures particularly in the pelvis and abdomen. It is a persistent seroma and is usually resistant to conservative methods of treatment such as percutaneous drainage and compression. Various methods of curative treatment have been reported in the literature, such as application of fibrin sealant, doxycycline, or alcohol sclerodhesis. We present a case of a huge recurrent Morel-Lavallée lesion in the lower back and buttock region that was treated with quilting sutures, fibrin sealant, and compression, with a review of the literature. © The Author(s) 2014.

CT characteristics of Morel-Lavallée lesions: an under-recognized but significant finding in acute trauma imaging.

Science.gov (United States)

McKenzie, Gavin A; Niederhauser, Blake D; Collins, Mark S; Howe, Benjamin M

2016-08-01

To highlight the significance and imaging characteristics of Morel-Lavallée (ML) lesions, which have been well characterized on MRI, but are potentially under-recognized on CT. Twenty-eight Morel-Lavallée lesions were identified in 18 patients and were all clinically or surgically confirmed. Lesions were grouped into acute (30 days) at the time of CT imaging. Charts were reviewed to gather patient characteristics, injury patterns, radiologist interpretation, treatment, and outcomes. Sixteen male and 2 female patients with a mean age of 50 years (range 19-80) at the date of their initial evaluation were identified. All patients had significant trauma that accounted for 28 ML lesions, all of which were in a characteristic subcutaneous location overlying the muscular fascial plane. Lesions on CT went through an evolution from hyperdense, poorly or moderately marginated without a pseudocapsule to being hypodense, with internal fat globules or septations and well marginated with a complete enhancing pseudocapsule. Only 1 (4 %) of the ML lesions was suggested and 7 (25 %) lesions were not commented on at all by the interpreting radiologist. Morel-Lavallée lesions are post-traumatic closed, internal, soft-tissue, degloving lesions that are potentially underrecognized on CT. Most acute ML lesions are nonspecific, resembling simple hematomas or contusions. ML lesions evolve as they age with subacute and chronic lesions demonstrating the known features described on MR imaging that should allow for an accurate imaging diagnosis.

Low energy electronic scattering processes in the topological Weyl semimetal TaAs

Energy Technology Data Exchange (ETDEWEB)

Muellner, Silvia; Lemmens, Peter [IPKM, TU-BS, Braunschweig (Germany); Gnezdilov, Vladimir [IPKM, TU-BS, Braunschweig (Germany); ILTPE NAS (Ukraine); Sankar, Raman; Chou, Fangcheng [CCMS, National Taiwan Univ., Taipei (China)

2016-07-01

The topological Weyl semimetal TaAs shows Weyl points as well as topological surface states (Fermi arcs) intimately related to symmetry and strong spin orbit interaction. We find evidence for a low energy maximum in the scattering intensity that is compatible with electronic correlations in a collision dominated regime. We compare our observations with topological insulators.

University Reform in Quebec: The Strike at Laval 1976. Yale Higher Education Research Group Working Paper.

Science.gov (United States)

Giles, Geoffrey J.

Quebec colleges remained firmly entrenched in the pure classicism of prerevolutionary France until well into the twentieth century. Formal Roman Catholic Church control of Laval University, a Jesuit university, ceased in 1965 at a time when the institution and its administration were expanding greatly, and the faculty quickly began to resent the…

Muusikamaailm : Schleswig-Holsteini festival 2001. Peter Sellars lavastab Bachi kantaate. Taas uus Soome ooper. Henze festival Londonis. Uus film Maria Callasest / Priit Kuusk

Index Scriptorium Estoniae

Kuusk, Priit, 1938-

2001-01-01

Schleswig-Holsteini suvisest muusikafestivalist 7.VII-2.IX 2001. a. New Yorgis tuli esiettekandele P. Sellarsi lavastatud etendus Bachi kantaatidest. Uue muusika festivalil "Musica Nova" Helsingis tuli esiettekandele T. Länsiö ooper "Sulka". H. W. Henze 75. juubelit tähistatakse Londonis festivaliga "Voices". F.Zeffirelli lavastab filmi M. Callasest

Validation of the Italian version of the Laval questionnaire: health-related quality of life in subjects with obesity.

Science.gov (United States)

Donini, Lorenzo Maria; Rosano, Aldo; Di Lazzaro, Luca; Poggiogalle, Eleonora; Lubrano, Carla; Migliaccio, Silvia; Carbonelli, Mariagrazia; Pinto, Alessandro; Lenzi, Andrea

2017-05-15

Obesity is associated to increased risk of metabolic comorbidity as well as increased mortality. Notably, obesity is also associated to the impairment of the psychological status and of quality of life. Only three questionnaires are available in the Italian language evaluating the health-related quality of life in subjects with obesity. The aim of the present study was to test the validity and reliability of the Italian version of the Laval Questionnaire. The original French version was translated into Italian and back-translated by a French native speaker. 273 subjects with obesity (Body Mass Index ≥ 30 kg/m 2 ) were enrolled; the Italian version of the Laval Questionnaire and the O.R.Well-97 questionnaire were administered in order to assess health- related quality of life. The Laval questionnaire consists of 44 items distributed in 6 domains (symptoms, activity/mobility, personal hygiene/clothing, emotions, social interaction, sexual life). Disability and overall psychopathology levels were assessed through the TSD-OC test (SIO test for obesity correlated disabilities) and the SCL-90 (Symptom Checklist-90) questionnaire, respectively. To verify the validity of the Italian version, the analysis of internal consistency, test-retest reliability, and construct validity were performed. The observed proportion of agreement concordance of results was 50.2% with Cohen's K = 0.336 (CI 95%: 0.267-0.404), indicating a fair agreement between the two tests. Test-retest correlation was statistically significant (ρ = 0.82; p  0.70). The analysis of construct validity showed a statistically significant association in terms of both total score (ρ = -0.66) and scores at each single domain (p obesity.

The Investigation of the Cavitation Phenomenon in the Laval Nozzle with Full and Partial Surface Wetting

Directory of Open Access Journals (Sweden)

Jablonská Jana

2017-04-01

Full Text Available The article deals with the cavitation phenomenon affected by full and partial wetting of the wall. For the numerical computation of flow in the Laval nozzle the Schnerr-Sauer cavitation model was tested and was used for cavitation research of flow within the nozzle considering partial surface wetting. The coefficient of wetting for various materials was determined using experimental, theoretical and numerical methods of fluid flow due to partial surface wetting.

[Morel-Lavallée lesion : Severely injured 13 year old after being run over].

Science.gov (United States)

Schmitt, F C F; Brenner, T; Hofer, S; Weigand, M A; Grützner, P A; Kneser, U; Kremer, T; Franke, J; Müller, U

2017-09-01

Accidents in which a person is run over are often associated with multiple serious injuries. Immediate bleeding control is crucial. Pressure and shear stress at the borders of subcutaneous tissue to the muscle fascia can cause hypoperfusion and the emergence of blood-filled cavities that are associated with a high risk of infection and necrosis, a so-called Morel-Lavallée lesion. Insufficient therapy can lead to local complications and furthermore to live-threatening sepsis.

Magnetic-Laval-Nozzle Effect on a Magneto-Plasma-Dynamic Arcjet

International Nuclear Information System (INIS)

Inutake, Masaaki; Miyazaki, Hiroyuki; Yoshino, Kyohei; Tobari, Hiroyuki; Hattori, Kunihiko; Ando, Akira

2003-01-01

A magneto-plasma-dynamic arcjet (MPDA) is one of the promising candidates for a manned interplanetary space thruster with a higher specific impulse and larger thrust. An MPDA with an externally-applied magnetic nozzle is investigated to improve the thrust efficiency. From spectroscopic measurements of the MPDA plasma, it is found that with the increase in the discharge current not only the flow velocity but also the ion temperature increase near the muzzle of the MPDA with a uniform axial magnetic field and so the ion acoustic Mach number is limited to a value less than unity. By installing a Laval-type magnetic nozzle near the muzzle of the MPDA, the subsonic flow is successfully accelerated to a supersonic one by converting the ion thermal energy to the flow energy. The results are compared with the prediction by a1-D isentropic flow model

Endoscopic debridement and fibrin glue injection of a chronic Morel-Lavallée lesion of the knee in a professional soccer player: A case report and literature review.

Science.gov (United States)

Koc, Baris B; Somorjai, Nicolaas; P M Kiesouw, Egid; Vanderdood, Kurt; Meesters-Caberg, Marleen; Draijer, Frits W; Jansen, Edwin J P

2017-01-01

A Morel-Lavallée lesion is a post-traumatic closed degloving injury of soft tissue. The lesion is due to a shearing trauma with separation of subcutaneous tissue from underlying fascia. When conservative treatment fails, surgical treatment is imperative. Commonly, open drainage and debridement is performed. This case report describes a Morel-Lavallée lesion of the knee in a professional soccer player who was successfully treated with endoscopic debridement and fibrin glue injection after failure of conservative management. This method achieves the goal of an open surgical debridement without exposing patients to an increased morbidity. Copyright © 2016. Published by Elsevier B.V.

Eesti teater välismaal : gastrollid ja saavutused aastal 2004 / Mari Kolle, Katrin Talts

Index Scriptorium Estoniae

Kolle, Mari

2004-01-01

Veebruaris andis Londoni Teatriühing balletipaarile A. Oks-T. Edur Briti teatripreemia, Laurence Olivier teatriauhinna; VAT Teatri lavastus "Kivid" hinnati Peterburi rahvusvahelisel noorsooteatrite festivalil "Vikerkaar" preemiaga "Parim lavastus väikesel laval"; Vanemuise lavastus "Roberto Zucco" võitis Poolas teatrifestivalil "Kontakt" II peaauhinna ja nimiosatäitja T. Tuisk parima noore näitleja auhinna; Von Krahli Teater võitis lavastusega "Luikede järv" New Yorgi Bessie-auhinna ; Jaapani rahvusvahelisel teatrifestivalil pälvis lavastaja J. Urvet parima meesnäitleja preemia osatäitmise eest "Niagaaras"; rahvusvaheliselt äratas tähelepanu eesti-soome ühistööna kirjutatud näidend "Taksojuhid", mille autorid on M. Ulman ja J. Niilekselä. Kaasaegse tantsu vallas olid rahvusvaheliste festivalide favoriidid M. Kangro, K. Essenson ja R. Keerd

Simultaneous occurrence of a severe Morel-Lavallée lesion and gluteal muscle necrosis as a sequela of transcatheter angiographic embolization following pelvic fracture: a case report.

Science.gov (United States)

Shimizu, Takayoshi; Matsuda, Shuichi; Sakuragi, Atsushi; Tsukie, Tomio; Kawanabe, Keiichi

2015-03-26

Morel-Lavallée lesions are posttraumatic hemolymphatic collections caused by disruption of the interfascial planes between the subcutaneous soft tissue and muscle. Severe peripelvic Morel-Lavallée lesions have rarely been reported in the literature. By contrast, a number of cases of gluteal muscle necrosis following transcatheter angiographic embolization for pelvic fracture have been reported. Each entity can result in severe infection and sepsis, and the mortality rate in such cases is quite high. However, to date, no previous reports have described a case in which these life-threatening entities occurred simultaneously. A 32-year-old Asian man simultaneously developed severe peripelvic Morel-Lavallée lesions and gluteal muscle necrosis with sepsis following transcatheter angiographic embolization after an unstable pelvic fracture. Extremely large skin and soft tissue defects, which were untreatable with any commonly used flaps, were generated after repeated debridement. In addition, a deep-bone infection was suspected in his left fractured iliac bone, while motor function was almost completely lost in his left leg, possibly as a sequela of transcatheter angiographic embolization. As a result of his condition, a left hemipelvectomy was unavoidable. A pedicled fillet flap from his sacrificed left limb was used for the treatment of the defects and to provide a durable base for a prosthesis. Our patient survived and returned to his previous job 24 months after the surgery wearing a prosthetic left leg. As illustrated by the present case, severe peripelvic Morel-Lavallée lesions and gluteal muscle necrosis following transcatheter angiographic embolization can occur simultaneously after unstable pelvic fractures. Physicians should recognize that these entities can result in life-threatening sepsis and, therefore, should attempt to detect them as early as possible. When hemipelvectomy is unavoidable, a pedicled upper and lower leg in-continuity fillet flap may

Mononuclear Amido and Binuclear Imido Zirconium Complexes Supported by Dibenzotetraaza[14]annulene Ligands. X-ray Structure of [(Me(4)taa)Zr(&mgr;-NR)(2)Zr(NHR)(2)] (R = Bu(t) or 2,6-C(6)H(3)Me(2)).

Science.gov (United States)

Nikonov, Georgii I.; Blake, Alexander J.; Mountford, Philip

1997-03-12

Reaction of 2 equiv of Li[NH-2,6-C(6)H(3)R(2)] with [(Me(4)taa)ZrCl(2)] (Me(4)taaH(2) = tetramethyldibenzotetraaza[14]annulene) gives the bis(amido) derivatives [(Me(4)taa)Zr(NH-2,6-C(6)H(3)R(2))(2)] [R = Pr(i) (1) and Me (2)]. Addition of Me(4)taaH(2) to [Zr(N-2,6-C(6)H(3)Pr(i)(2))(NH-2,6-C(6)H(3)Pr(i)(2))(2)(py)(2)] also affords 1. The reaction of 2 equiv of aryl or alkyl amines H(2)NR with the bis(alkyl) complex [(Me(4)taa)Zr(CH(2)SiMe(3))(2)] is the most versatile method for preparing [(Me(4)taa)Zr(NHR)(2)] (R = 2,6-C(6)H(3)Pr(i)(2), 2,6-C(6)H(3)Me(2), Ph, or Bu(t)). Reaction of 1 equiv of Me(4)taaH(2) with the binuclear complexes [(Bu(t)NH)(2)Zr(&mgr;-NBu(t))(2)Zr(NHBu(t))(2)] or [(py)(HN-2,6-C(6)H(3)Me(2))(2)Zr(&mgr;-N-2,6-C(6)H(3)Me(2))(2)Zr(NH-2,6-C(6)H(3)Me(2))(2)(py)] gives the asymmetrically substituted derivatives [(Me(4)taa)Zr(&mgr;-NR)(2)Zr(NHR)(2)] [R = Bu(t) (6) or 2,6-C(6)H(3)Me(2) (8)], which have been crystallographically characterized.

Muusikamaailm : Suvi Verona Arenal. Lahti uus Sibelius-talo. Poul Rudersi uus ooper. Boulezi juubeldamine Londonis ja New Yorgis. "Tosca" sünnist möödus sajand / Priit Kuusk

Index Scriptorium Estoniae

Kuusk, Priit, 1938-

2000-01-01

Verona Arena 78. ooperifestivalist 2000. a. suvel ja selle programmist, mis on pühendatud G. Verdi 100. surma-aastapäevale. Lahti uuest kontserdimajast Sibelius-talo ja selle avamisest. P. Rudersi uue ooperi "Teenijanna lugu ("Tjenerindens fortaelling") maailmaesiettekandest 6. märtsil Taani Kuninglikus Ooperis. P. Boulezi juubelikontsertidest LSO-ga Londonis ja New Yorgis. Tähistamaks saja aasta möödumist G. Puccini ooperi "Tosca" esiettekandest Roomas tõi Milano "La Scala" välja uue "Tosca" lavastuse

Lumbar Morel-Lavallée lesion: Case report and review of the literature.

Science.gov (United States)

Zairi, F; Wang, Z; Shedid, D; Boubez, G; Sunna, T

2016-06-01

The Morel-Lavallée lesion (MLL) is a rarely reported closed degloving injury, in which shearing forces have lead to break off subcutaneous tissues from the underlying fascia. Lumbar MLL have been rarely reported to date, explaining that patients are frequently misdiagnosed. While patients could be treated conservatively or with non-invasive procedures, delayed diagnosis may require open surgery for its cure. Indeed, untreated lesions can cause pain, infection or growing subcutaneous mass that can be confused with a soft tissue tumor. We report the clinical and radiological features of a 45-year old man with voluminous lumbar MLL initially misdiagnosed. We also reviewed the relevant English literature to summarize the diagnostic tools and the main therapeutic options. Copyright © 2016 Elsevier Masson SAS. All rights reserved.

Can a Morel-Lavallée lesion be misdiagnosed as a mass like lesion?

Science.gov (United States)

Lee, Yoon Jae; Kim, Jun Hyeok; Kim, Ji Young; Han, Hyun Ho

2017-12-01

The Morel-Lavallée lesion (MLL) is a post-traumatic closed soft tissue degloving injury. Common complaints of MLL patients are a haematoma or fluid collection on the trunk or the lower extremity. However, the authors introduce unique cases of MLL that present an atypical appearance. The fluid collection was not apparent, and the capsule formation was not detected on preoperative image study. The main complaint of patients was the uncomfortable mass-like lesion that was regarded as a simple benign lump. The purpose of this case study is to introduce the atypical cases of MLL and to help other physicians make accurate diagnosis based on trial and error of our cases. © 2017 Medicalhelplines.com Inc and John Wiley & Sons Ltd.

The Morel-Lavallée Lesion as a Rare Differential Diagnosis for Recalcitrant Bursitis of the Knee: Case Report and Literature Review

Directory of Open Access Journals (Sweden)

Ivor S. Vanhegan

2012-01-01

Full Text Available A 72 year-old-male was referred to our institution with recalcitrant prepatellar bursitis. The injury was sustained after striking his right knee against a post whilst horse riding 9 months ago. Previous treatments included repeated aspiration and excision of the bursa with elastic compression bandaging. A diagnosis of a Morel-Lavallée internal degloving injury was made, and the lesion was satisfactorily managed by an internal quilting procedure to eliminate the potential dead space. A review of the literature reveals 29 published reports of Morel-Lavallée lesions with sufficient information for inclusion. These came from 14 separate countries with a total of 204 lesions in 195 patients. The most common anatomical location was the greater trochanter/hip (36%, followed by the thigh (24% and the pelvis (19%. Most were managed surgically with evacuation of the haematoma and necrotic tissue followed by debridement, which was often repeated (36%. Conservative treatment with percutaneous aspiration and compression bandaging was the next most common treatment (23%. The knee was the fourth most common region affected (16%, and only 3 other lesions in the literature have been managed with a quilting procedure.

Airfoil sampling of a pulsed Laval beam with tunable vacuum ultraviolet synchrotron ionization quadrupole mass spectrometry: application to low-temperature kinetics and product detection.

Science.gov (United States)

Soorkia, Satchin; Liu, Chen-Lin; Savee, John D; Ferrell, Sarah J; Leone, Stephen R; Wilson, Kevin R

2011-12-01

A new pulsed Laval nozzle apparatus with vacuum ultraviolet (VUV) synchrotron photoionization quadrupole mass spectrometry is constructed to study low-temperature radical-neutral chemical reactions of importance for modeling the atmosphere of Titan and the outer planets. A design for the sampling geometry of a pulsed Laval nozzle expansion has been developed that operates successfully for the determination of rate coefficients by time-resolved mass spectrometry. The new concept employs airfoil sampling of the collimated expansion with excellent sampling throughput. Time-resolved profiles of the high Mach number gas flow obtained by photoionization signals show that perturbation of the collimated expansion by the airfoil is negligible. The reaction of C(2)H with C(2)H(2) is studied at 70 K as a proof-of-principle result for both low-temperature rate coefficient measurements and product identification based on the photoionization spectrum of the reaction product versus VUV photon energy. This approach can be used to provide new insights into reaction mechanisms occurring at kinetic rates close to the collision-determined limit.

FTIR spectroscopy of UF6 clustering in a supersonic Laval nozzle

International Nuclear Information System (INIS)

Tanimura, Shinobu; Okada, Yoshiki; Takeuchi, Kazuo

1996-01-01

The clustering of UF 6 seeded in Ar was observed in a continuous supersonic Laval nozzle flow. The onset conditions for UF 6 clustering were investigated by measuring the FTIR spectra of UF 6 monomer and clusters in the nozzle. The onset conditions for the clustering, temperature, density of UF 6 (or partial pressure), and cooling rate, were determined. The onset temperature determined here was higher by 40-50 K than that determined by a light-scattering method. The frequency shift of the main peak of the UF 6 clusters from the monomer peak was about -17 cm -1 , which was smaller than the shift of the crystalline UF 6 by about 11 cm -1 . The increase in temperature caused by the heat of condensation and the change of the spectra of UF 6 clusters with the growth after the onset were also observed. It was shown that the clustering rate due to the collision between the monomer and cluster is much higher than that due to the collision between the monomers. 19 refs., 9 figs

Equipment for fully homologous bulb turbine model testing in Laval University

International Nuclear Information System (INIS)

Fraser R; Vallée D; Jean Y; Deschênes C

2014-01-01

Within the context of liberalisation of the energy market, hydroelectricity remains a first class source of clean and renewable energy. Combining the growing demand of energy, its increasing value and the appreciation associated to the sustainable development, low head sites formerly considered as non-profitable are now exploitable. Bulb turbines likely to equip such sites are traditionally developed on model using right angle transmission leading to piers enlargement for power take off shaft passage, thus restricting possibilities to have fully homologous hydraulic passages. Aiming to sustain good quality development on fully homologous scale model of bulb turbines, the Hydraulic Machines Laboratory (LAMH) of Laval University has developed a brake with an enhanced power to weight ratio. This powerful brake is small enough to be located in the bulb shell while dissipating power without mandatory test head reduction. This paper first presents the basic technology of this brake and its application. Then both its main performance capabilities and dimensional characteristics will be detailed. The instrumentation used to perform accurate measurements will be finally presented

Observation of propane cluster size distributions during nucleation and growth in a Laval expansion

Energy Technology Data Exchange (ETDEWEB)

Ferreiro, Jorge J.; Chakrabarty, Satrajit; Schläppi, Bernhard; Signorell, Ruth [Laboratory of Physical Chemistry, ETH Zürich, Vladimir-Prelog Weg 2, CH-8093 Zürich (Switzerland)

2016-12-07

We report on molecular-level studies of the condensation of propane gas and propane/ethane gas mixtures in the uniform (constant pressure and temperature) postnozzle flow of Laval expansions using soft single-photon ionization by vacuum ultraviolet light and mass spectrometric detection. The whole process, from the nucleation to the growth to molecular aggregates of sizes of several nanometers (∼5 nm), can be monitored at the molecular level with high time-resolution (∼3 μs) for a broad range of pressures and temperatures. For each time, pressure, and temperature, a whole mass spectrum is recorded, which allows one to determine the critical cluster size range for nucleation as well as the kinetics and mechanisms of cluster-size specific growth. The detailed information about the size, composition, and population of individual molecular clusters upon condensation provides unique experimental data for comparison with future molecular-level simulations.

Morel-Lavallée Lesion of the Knee in a Recreational Frisbee Player

Directory of Open Access Journals (Sweden)

Alison Shmerling

2016-01-01

Full Text Available Traumatic swelling/effusion in the knee region is a relatively common presenting complaint among athletes and nonathletes. Due to its broad differential diagnosis, a comprehensive evaluation beginning with history and physical examination are recommended. Knee joint effusion can be differentiated from other types of swelling by careful physical examination. Imaging, including plain radiography, ultrasound, and magnetic resonance imaging (MRI, is preferred modality. Aspiration of a local fluctuating mass may help with the diagnosis and management of some of these conditions. We present a case of a 26-year-old gentleman with superomedial Morel-Lavallée lesion (MLL of the knee with history of a fall during a Frisbee game. His MLL was successfully treated with therapeutic aspiration and compression wrap without further sequelae. MLL is a rare condition consisting of a closed degloving injury caused by pressure and shear stress between the subcutaneous tissue and the superficial fascia or bone. Most commonly, MLL is found over the greater trochanter and sacrum but in rare cases can occur in other regions of the body. In most cases, concurrent severe injury mechanisms and concomitant fractures are present. MLL due to sports injuries are very rare. Therapeutic strategies may vary from compression wraps and aspiration to surgical evacuation.

Expectations of clinical teachers and faculty regarding development of the CanMEDS-Family Medicine competencies: Laval developmental benchmarks scale for family medicine residency training.

Science.gov (United States)

Lacasse, Miriam; Théorêt, Johanne; Tessier, Sylvie; Arsenault, Louise

2014-01-01

The CanMEDS-Family Medicine (CanMEDS-FM) framework defines the expected terminal enabling competencies (EC) for family medicine (FM) residency training in Canada. However, benchmarks throughout the 2-year program are not yet defined. This study aimed to identify expected time frames for achievement of the CanMEDS-FM competencies during FM residency training and create a developmental benchmarks scale for family medicine residency training. This 2011-2012 study followed a Delphi methodology. Selected faculty and clinical teachers identified, via questionnaire, the expected time of EC achievement from beginning of residency to one year in practice (0, 6, 12, […] 36 months). The 15-85th percentile intervals became the expected competency achievement interval. Content validity of the obtained benchmarks was assessed through a second Delphi round. The 1st and 2nd rounds were completed by 33 and 27 respondents, respectively. A developmental benchmarks scale was designed after the 1st round to illustrate expectations regarding achievement of each EC. The 2nd round (content validation) led to minor adjustments (1.9±2.7 months) of intervals for 44 of the 92 competencies, the others remaining unchanged. The Laval Developmental Benchmarks Scale for Family Medicine clarifies expectations regarding achievement of competencies throughout FM training. In a competency-based education system this now allows identification and management of outlying residents, both those excelling and needing remediation. Further research should focus on assessment of the scale reliability after pilot implementation in family medicine clinical teaching units at Laval University, and corroborate the established timeline in other sites.

Comparative Raman study of Weyl semimetals TaAs, NbAs, TaP and NbP

International Nuclear Information System (INIS)

Liu, H W; Richard, P; Zhao, L X; Chen, G-F; Ding, H

2016-01-01

We report a comparative polarized Raman study of Weyl semimetals TaAs, NbAs, TaP and NbP. The evolution of the phonon frequencies with the sample composition allows us to determine experimentally which atoms are mainly involved for each vibration mode. Our results confirm previous first-principles calculations indicating that the A 1 , B 1 (2), E(2) and E(3) modes involve mainly the As(P) atoms, the B 1 (1) mode is mainly related to Ta(Nb) atoms, and the E(1) mode involves both kinds of atoms. By comparing the energy of the different modes, we establish that the B 1 (1), B 1 (2), E(2) and E(3) become harder with increasing chemical pressure. This behaviour differs from our observation on the A 1 mode, which decreases in energy, in contrast to its behaviour under external pressure. (paper)

Effects of dimensional size and surface roughness on service performance for a micro Laval nozzle

International Nuclear Information System (INIS)

Cai, Yukui; Liu, Zhanqiang; Shi, Zhenyu

2017-01-01

Nozzles with large and small dimensions are widely used in various industries. The main objective of this research is to investigate the effects of dimensional size and surface roughness on the service performance of a micro Laval nozzle. The variation of nozzle service performance from the conventional macro to micro scale is presented in this paper. This shows that the dimensional nozzle size has a serious effect on the nozzle gas flow friction. With the decrease of nozzle size, the velocity performance and thrust performance deteriorate. The micro nozzle performance has less sensitivity to the variation of surface roughness than the large scale nozzle does. Surface quality improvement and burr prevention technologies are proposed to reduce the friction effect on the micro nozzle performance. A novel process is then developed to control and depress the burr generation during micro nozzle machining. The polymethyl-methacrylate as a coating material is coated on the rough machined surface before finish machining. Finally, the micro nozzle with a throat diameter of 1 mm is machined successfully. Thrust test results show that the implement and application of this machining process benefit the service performance improvement of the micro nozzle. (paper)

Sailing in Brazilian waters: the information from French Pyrard of Laval on the Brazilian colony (1610-1611

Directory of Open Access Journals (Sweden)

Maria Isabel de Siqueira

2014-07-01

Full Text Available The presence of travelers/sailors in American lands after the conquest contributed to the circulation of useful information about the potential of these regions. The natural resources that the new lands had aroused the interest of Europeans in these products targeting the trade. The official (or unofficial visit of  travelers to these lands resulted in records of the conditions of the earth, and their habits of obedience towards the laws enacted by cities to control their colonies. Our purpose in these notes is to identify the narrative of Pyrard de Laval, written in the early seventeenth century, the habits, the customs, the laws, the organization of cities, and finally the social behavior and relations between State and society in the Portuguese colony of America. In this sense, we understand, from the contribution of the author on the exploitation of natural resources  and agricultural practices in the vicinity of the Baía de Todos os Santos, licit and illicit relations of this social dynamic.

S’alimenter à la source de Pinterest : utilisation de Pinterest pour la mise en valeur des nouveautés en format électronique de la Bibliothèque de l’Université Laval

Directory of Open Access Journals (Sweden)

Daniela Zavala Mora

2015-12-01

Full Text Available Le 24 septembre 2013, la Bibliothèque de l’Université Laval (BUL lançait le projet pilote de mise en valeur des nouveautés en format électronique sur Pinterest pour la Faculté des sciences de l’agriculture et de l’alimentation (FSAA. Pinterest, un « tableau d’affichage » virtuel, permet d’organiser et de partager des images, liées à des URL, sur différents sujets. Grâce à son interface conviviale et visuellement attrayante, Pinterest compte, en 2015, 72,8 millions d’utilisateurs, le Canada figurant au deuxième rang quant au nombre d’utilisateurs, après les États-Unis. Plusieurs bibliothèques et établissements scolaires utilisent maintenant Pinterest pour donner une meilleure visibilité à leurs services et à leurs collections. La BUL est la première bibliothèque universitaire francophone au Canada à utiliser le réseau social Pinterest pour la promotion de sa collection et de ses services. Cet outil permet de mettre en valeur la collection de la Bibliothèque et donne aux usagers la possibilité de partager du contenu. Cet article se penche sur la façon dont l’outil Pinterest a été utilisé à la BUL. Dans un premier temps, les objectifs, le public ciblé et leur contexte seront exposés. Le fonctionnement des statistiques d’utilisation de Pinterest, avec l’outil Pinterest Analytics, sera analysé ainsi que leur utilisation dans le contexte de ce projet. L’article vise également à partager avec la communauté des professionnels de l’information les pratiques appliquées à la mise en place de ce projet. On September 24, 2013 Laval University Library launched a pilot project to promote newly acquired eBooks for the Faculty of Food and Agriculture using Pinterest. Pinterest is an online pinboard that allows organizing and sharing images, linked to a URL, about different subjects. It’s user friendly and visually attractive interface reached, in 2015, 72,8 million users. Canada is the second

Muusikamaailm : Euroopa kultuurilinnad 2002. Monserrat Caballe taas laval. Murray Perahia Beethooveniga. Kurt Sanderling lõpetab tegevuse / Priit Kuusk

Index Scriptorium Estoniae

Kuusk, Priit, 1938-

2002-01-01

Euroopa kultuurilinnades 2002 ئ Salamancas ja Brügges toimuvatest muusikasündmustest. Monserrat Caballe tegi comebacki ooperilavale. PianistMurray Perahia kavandab kõigi Beethooveni klaverikontsertide ettekande. 89aastane Kurt Sanderling otsustas lõpetada tegevdirigendi karjääri

President tuli "koju" : President Toomas H. Ilves NY Eesti Majas

Index Scriptorium Estoniae

2007-01-01

President Toomas Hendrik Ilvese ja proua Evelin Ilvese külaskäigust New Yorgi Eesti Majja 23. septembril 2007. Tervitussõnavõttudega esinesid New Yorgi Eesti Haridusseltsi esimees dr. Toomas Sõrra, New Yorgi Eesti Kooli juhataja Karin Kärner. Kirjaliku tervituse saatis presidendile tema omaaegne skaudijuht Emu Saarniit. President T.H. Ilves meenutas oma sõnavõtus, et esimest korda külastas ta New Yorgi Eesti Maja 50 aastat tagasi. Pärast ametlike sõnavõttude lõppu said kõik kohaletulnud isiklikult presidenti tervitada. Vabariigi President töövisiidil Ameerika Ühendriikides 20.-26.09.2007

Muusikamaailm : Weimari Riigikapell 400. Korngoldi mälestuspäevad Brnos. Ooperietendus taas Indias. Uusooperid laval Euroopas / Priit Kuusk

Index Scriptorium Estoniae

Kuusk, Priit, 1938-

2002-01-01

Weimari Riigikapell tähistab oma 400. aastapäeva. Brnos tähistatakse mitmete muusikasündmustega helilooja Erich Wolfgang Korngoldi mälestuspäevasid. New Delhi Siri Forti auditooriumis kõlab üle hulga aja ooper. Euroopa eri linnades toimuvatest ooperite uusalvastustest

Kurikaelte murdja müüb Mehhikos nulltolerantsi / Kaivo Kopli

Index Scriptorium Estoniae

Kopli, Kaivo

2003-01-01

Mexico sõlmis New Yorgi endise linnapea Rudolph Giuliani konsultatsioonifirmaga lepingu, mis näeb ette kuritegevuse vastase võitluse edendamist sarnaste meetoditega, mida Giuliani kasutas New Yorgis

Manhattanile autoga minek läheb maksu alla / Neeme Raud

Index Scriptorium Estoniae

Raud, Neeme, 1969-

2007-01-01

New Yorgis toimunud maailma suurlinnajuhtide kliimafoorumil propageeris Londoni linnapea Ken Livingston linnasüdametesse sissesõidutasu kehtestamist, New Yorgi meer Michael Bloomberg plaanib kehtestada Manhattanile sissesõidu eest kaheksadollarilise tasu. Lisa: Suurlinnad autosid piiramas

Kuus miljardit krooni muutus tunniga rusudeks / Kaarel Kaas

Index Scriptorium Estoniae

Kaas, Kaarel, 1978-

2001-01-01

Arvandmeid jaapani arhitekti Minoru Yamasaki projekteeritud World Trade Center'i (WTC) kohta New Yorgis. Kahe kõrghoone hävinemise ajakava 11. septembril 2001. Skeemid ja kaart: New Yorgi siluetis olnud tornmajade hävimine

Woody Allen kimpus arhitektuuriga

Index Scriptorium Estoniae

2000-01-01

Woody Allen protesteerib oma uue lühifilmiga kavatsuse vastu ehitada 16-korruseline ärihoone tema New Yorgi kodu lähedale. W. Allen hindab New Yorgi ajaloolisi rajoone, mida näitab ka oma filmides

Ilves osaleb ÜRO Peaassamblee 62. istungjärgul

Index Scriptorium Estoniae

2007-01-01

President Toomas Hendrik Ilves osaleb New Yorgis ÜRO peaassamblee 62. istungjärgu töös. Eesti riigipea osaleb ka ÜRO korraldatud kliimamuutuste konverentsil, kohtub ÜRO peasekretäri ja Makedoonia, Slovakkia ning Bosnia ja Hertsegoviina presidendiga, samuti filantroop George Sorosega ning osaleb Baltimaade riigipeade kohtumisel. T.H. Ilves külastab ka Columbia Ülikooli ning osaleb New Yorgi Eesti haridusseltsi korraldatud vastuvõtul New Yorgi Eesti Majas. Vabariigi President töövisiidil Ameerika Ühendriikides 20.-26.09.2007

Eestlanna armukadeduse antidoodina Off-Off- Broadwayl / Mardi Valgemäe

Index Scriptorium Estoniae

Valgemäe, Mardi, 1935-

2007-01-01

pikemat aega New Yorgi teatrites tegutsenud eesti soost näitlejatari Reet Roos Värniku rollist Fernand Crommelyncki komöödias "Suurepärane sarvekandja" New Yorgi Off-Off Broadway rühmitises East Rives Commedia, mida esitatakse Connelly teatris

Morel-Lavallée Lesions of the Knee: MRI Findings Compared With Cadaveric Study Findings.

Science.gov (United States)

Vassalou, Evangelia E; Zibis, Aristeidis H; Raoulis, Vasileios A; Tsifountoudis, Ioannis P; Karantanas, Apostolos H

2018-05-01

The purpose of this study is to describe the MRI findings and treatment decisions and outcome for Morel-Lavallée lesions (MLLs) of the knee and to investigate whether evidence exists to support an increased frequency of such lesions on the medial or lateral side by performing a cadaveric experiment. In a 4-year period, 24 MRI studies of 24 consecutive patients (16 male patients and eight female patients) with knee MLLs were retrospectively reviewed. Patient demographic characteristics, treatment decisions and outcome, and associated injuries were recorded. The location of the MLL was categorized as medial, lateral, or global. Lesions were categorized according to an established MRI classification. During the cadaveric experiment, the compartmental pressures of the medial or lateral aspect of the knee were monitored in 20 cadaveric knees. The chi-square test, t test, and Pearson correlation were used for statistical analysis. MLLs were located medially in 16 patients, laterally in two patients, and globally in six patients. The medial location was significantly more common than a lateral or global location (p < 0.05). MLLs were classified as type I in 14 patients, type II in eight patients, and type III in two patients. MRI type was correlated with the chronicity of injury (r 2 = 0.614; p = 0.0014). Fractures were the most common associated injuries, occurring in seven of 24 patients. In 17 patients, all of whom had conservatively treated type I or type II lesions, complete resolution of the MLL occurred. The maximum compartmental pressures were significantly higher on the lateral side than on the medial side (p < 0.0001). Knee MLLs have a predilection for the medial side, which may be attributed to the lower resistance in this location, and they have variable patterns on MRI, which correlate with chronicity. Conservative treatment of type I and II lesions seems effective.

Amerika isportila sebe festival

Index Scriptorium Estoniae

2002-01-01

Aki Kaurismäki keeldus sõitmast New Yorgi rahvusvahelisele filmifestivalile oma filmiga "Minevikuta mees", kuna iraani mainekas režissöör Abbas Kiarostami ei saanud sissesõiduviisat. Kõik piletid Kiarostami filmi "Kümme" ("Ten") esilinastusele New Yorgis on müüdud

Martin Saar kahe kunstimaailma vahel / Marian Kivila

Index Scriptorium Estoniae

Kivila, Marian, 1985-

2011-01-01

Kunstnik Martin Saare, kelle näitus "Order and Chaos" ("Kord ja kaos") on 31. augustini 2011 avatud galeriis Vaal, loomingust. Samas intervjuus räägib New Yorgis elav kunstnik New Yorgi kunstimaailmast, oma karjäärist, loomingust, kunstieelistustest ja eesmärkidest

Come home, says Ilves

Index Scriptorium Estoniae

2010-01-01

President Toomas Hendrik Ilves ja proua Evelin Ilves külastasid 25. septembril 2010. a. New Yorgi Eesti Majas tegutsevat Eesti kooli ja osalesid New Yorgi eestlaskonnale korraldatud vastuvõtul, kus riigipea tutvustas programmi "Talendid koju". Töövisiit Ameerika Ühendriikidesse 20.-27.09.2010

Eesti riiklik autasu Portugali presidendile

Index Scriptorium Estoniae

2008-01-01

President Toomas Hendrik Ilves andis 24. septembril 2008 New Yorgis Portugali presidendile Anibal Cavaco Silvale üle Maarjamaa Risti teenetemärgi keti. Portugali president pälvis teenetemärgi Balti riikide annekteerimise mittetunnustamispoliitika toetamise eest. Vabariigi President töövisiidil New Yorgis 23.-27.09.2008

Une formation à distance pour la certification des compétences à l’ère du numérique : le projet C2i Université Laval - Université de Bordeaux

Directory of Open Access Journals (Sweden)

Jean-François Lévesque

2010-01-01

Full Text Available Il est désormais devenu indispensable de maîtriser les technologies de l’information et de la communication (TIC pour entreprendre avec succès des études universitaires. Sur ce point, la prise de conscience est de plus en plus forte et la question de la certification des compétences requises à l’ère du numérique devient un enjeu pour les universités. À partir d’un projet pilote mené dans le cadre de la collaboration internationale entre l’Université Laval (Québec et l’Université de Bordeaux (France, nous nous interrogeons dans cet article sur les conditions de mise en place d’une formation à distance en réponse à cette préoccupation.

Evaluating the Fabreville Heart Health Program in Laval, Canada: a dialogue between two paradigms, positivism and constructivism.

Science.gov (United States)

Nguyen, Minh Nguyet; Otis, Joanne

2003-06-01

As part of the Canadian Federal-Provincial Initiative in Heart Health, the goal of the Fabreville Heart Health Program was to sensitize a district of Laval, Quebec's second most populous city, to heart-healthy behaviours. The program was planned and implemented by a committee composed of Fabreville community leaders and professionals from the Public Health Department. Between 1992 and 1994, intervention objectives were defined by the department in terms of changing individual behaviours associated with cardiovascular risk factors, namely diet, sedentariness and smoking, as well as adapting physical and social environments to facilitate these changes. However, from 1994 to its conclusion in 1997, the program was re-oriented to engage the population in mobilizing their own community and taking charge of interventions themselves. Actions then became dependent on the interests and motivation of Fabreville residents to transform their lifestyles and aspects of their physical environment. The initial evaluation process, based on the positivist paradigm, was designed to measure changes in individual behaviours and certain physical environments, such as an increase in designated non-smoking areas. However, following the re-orientation towards community mobilization, it was decided that evaluation should go beyond the professional production of data to include a process of the collective construction of knowledge. Evaluation methodology then became based on the constructivist paradigm. Yet field constraints such as lack of community involvement in both leadership and process evaluation, and the need to ensure evaluation standards and fulfil sponsor obligations, compelled the Public Health Department to return to using a certain number of positivist methods. The ensuing inter-paradigm dialogue helped broaden the scope of evaluation and contributed to gaining a more in-depth understanding of the processes and outcomes of community mobilization.

Kindrali saatus : Lavastus kindral Laidonerist jõuab Ameerika Ühendriikidesse / Mart Laar

Index Scriptorium Estoniae

Laar, Mart

2008-01-01

Mart Kivastiku lavastusest "Sõdur" - Johan Laidoneri viimastest aastatest. Etendust mängitakse New Yorgis, Baltimores, Chicagos ja Los Angeleses New Yorgi Eesti Kultuuripäevade 2008 raames. Artikkel sisaldab eluloolisi andmeid Johan Laidonerist, tema naisest Mariast, Konstantin Pätsist ja August Reist ning fakte NSV Liidu ettevalmistustöödest terrori vallandamiseks, rahvusliku eliidi kavakindlaks hävitamiseks juba enne Eesti okupeerimist

Effects of Nozzle Configuration on Rock Erosion Under a Supercritical Carbon Dioxide Jet at Various Pressures and Temperatures

Directory of Open Access Journals (Sweden)

Man Huang

2017-06-01

Full Text Available The supercritical carbon dioxide (SC-CO2 jet offers many advantages over water jets in the field of oil and gas exploration and development. To take better advantage of the SC-CO2 jet, effects of nozzle configuration on rock erosion characteristics were experimentally investigated with respect to the erosion volume. A convergent nozzle and two Laval nozzles, as well as artificial cores were employed in the experiments. It was found that the Laval nozzle can enhance rock erosion ability, which largely depends on the pressure and temperature conditions. The enhancement increases with rising inlet pressure. Compared with the convergent nozzle, the Laval-1 nozzle maximally enhances the erosion volume by 10%, 21.2% and 30.3% at inlet pressures of 30, 40 and 50 MPa, respectively; while the Laval-2 nozzle maximally increases the erosion volume by 32.5%, 49.2% and 60%. Moreover, the enhancement decreases with increasing ambient pressure under constant inlet pressure or constant pressure drop. The growth of fluid temperature above the critical value can increase the enhancement. In addition, the jet from the Laval-2 nozzle with a smooth inner profile always has a greater erosion ability than that from the Laval-1 nozzle.

Replacement of Coconut Oils with Unsaturated Oils in Recombined Filled Milk

Science.gov (United States)

1992-10-01

preliminary study only) or high-temperature-short-time ( HTST ) pasteurization. The milk was cooled, packaged and stored at 35 0F. In formulations where Actoloids...Each of 30 gallon formulation was then processed through a De Laval 460 GPH HTST pasteurizer (De Laval Brand, Alfa-Laval Agri Inc., Everett, MA) and...However, it was noted that HTST pasteurization greatly reduced the extent to which these defects were noticed. Furthermore, an increase in the percent

75 FR 1345 - Solicitation of Applications for the Community Trade Adjustment Assistance Program

Science.gov (United States)

2010-01-11

... communities respond to the loss of jobs caused by the layoffs at firms and other types of employers impacted..., planning, and infrastructure projects to help communities adapt to pressing trade impact issues and... the following three Trade Adjustment Assistance (TAA) programs: TAA for Workers, TAA for Firms, or TAA...

Taka-amylase A in the conidia of Aspergillus oryzae RIB40.

Science.gov (United States)

Nguyen, Cong Ha; Tsurumizu, Ryoji; Sato, Tsutomu; Takeuchi, Michio

2005-11-01

A study of Taka-amylase A of conidia from Aspergillus oryzae RIB40 was done. During the research, proteins from conidia and germinated conidia were analyzed using SDS-PAGE, 2-D gel electrophoresis, Western blot analysis, MALDI-TOF Mass spectrometry, and native-PAGE combined with activity staining of TAA. The results showed that TAA exists not only in germinated conidia but also in conidia. Some bands representing degraded products of TAA were detected. Conidia, which formed on starch (SCYA), glucose (DCYA), and glycerol (GCYA) plates, contained mature TAA. Only one active band of TAA was detected after native-PAGE activity staining. In addition, TAA activity was detected in cell extracts of conidia using 0.5 M acetate buffer, pH 5.2, as extraction buffer, but was not detected in whole conidia or cell debris. The results indicate that TAA exists in conidia in active form even when starch, glucose, or glycerol is used as carbon source. TAA might belong to a set of basal proteins inside conidia, which helps in imbibition and germination of conidia.

Siim Nestor soovitab : Uued hip-hop teosed live'is / Siim Nestor

Index Scriptorium Estoniae

Nestor, Siim, 1974-

2006-01-01

Põhjamaade Hirmu esikplaadi "Maailma südame põhjast" esitlustest Tallinnas ja 9. juunil Tartus klubis Illusion. TommyBoy uue heliplaadi "Suur pilt" esitlustest Tallinnas ja 9. juunil Rakvere teatrikohviku laval, Stupid F heliplaadi "Nostalgilised helid"esitlusest 9. juunil Rakvere teatrikohviku laval

PPARα ligands activate antioxidant enzymes and suppress hepatic fibrosis in rats

International Nuclear Information System (INIS)

Toyama, Tetsuya; Nakamura, Hideki; Harano, Yuichi; Yamauchi, Norihito; Morita, Atsuhiro; Kirishima, Toshihiko; Minami, Masahito; Itoh, Yoshito; Okanoue, Takeshi

2004-01-01

Oxidative stress is a major pathogenetic factor in hepatic fibrosis. Peroxisome proliferator-activated receptor α (PPARα) is a nuclear receptor which is known to affect oxidative stress and PPARα ligands may have rescue effects on hepatic fibrosis. We tested this hypothesis using rat thioacetamide (TAA) models of liver cirrhosis. Rats were given intraperitoneal injection of TAA and treated with a diet containing one of the two PPARα ligands, Wy-14,643 (WY) or fenofibrate. WY treatment dramatically reduced hepatic fibrosis and also prevented the inhibition catalase of mRNA expression caused by TAA. Correspondingly, catalase activity increased in the TAA + WY group but decreased in the control TAA group. The antifibrotic action of fenofibrate in the TAA model was comparable with that of WY. PPARα ligands have an antifibrotic action in the rat TAA model of liver cirrhosis, probably due to an antioxidant effect of enhanced catalase expression and activity in the liver

Trimeric autotransporter adhesins in members of the Burkholderia cepacia complex: a multifunctional family of proteins implicated in virulence

Directory of Open Access Journals (Sweden)

Arsénio Mendes Fialho

2011-12-01

Full Text Available Trimeric autotransporter adhesins (TAAs are multimeric surface proteins, involved in various biological traits of pathogenic Gram-negative bacteria including adherence, biofilm formation, invasion, survival within eukaryotic cells, serum resistance and cytotoxicity. TAAs have a modular architecture composed by a conserved membrane-anchored C-terminal domain and a variable number of stalk and head domains. In this study, a bioinformatic approach has been used to analyze the distribution and architecture of TAAs among Burkholderia cepacia complex (Bcc genomes. Fifteen genomes were probed revealing a total of 74 encoding sequences. Compared with other bacterial species, the Bcc genomes contain a disproportionately large number of TAAs (two genes to up to 8 genes, such as in B.cenocepacia. Phylogenetic analysis showed that the TAAs grouped into at least eight distinct clusters. TAAs with serine-rich repeats are clearly well separated from others, thereby representing a different evolutionary lineage. Comparative gene mapping across Bcc genomes reveals that TAA genes are inserted within conserved synteny blocks. We further focused our analysis on the epidemic strain B. cenocepacia J2315 in which 7 TAAs were annotated. Among these, 3 TAA-encoding genes (BCAM019, BCAM0223 and BCAM0224 are organized into a cluster and are candidates for multifunctional virulence factors. Here we review the current insights into the functional role of BCAM0224 as a model locus.

Training for my Life: Lived Experiences of Dislocated Workers in an Advanced Manufacturing Training Program

Directory of Open Access Journals (Sweden)

Marquita R. Walker

2012-07-01

Full Text Available This qualitative paper explores the lived experiences of one group of workers dislocated because of globalized trade policies who completed a hybrid Advanced Manufacturing Training Program (AMTP by taking advantage of Trade Adjustment Assistance (TAA, a federally-funded program for retraining workers dislocated because of trade policies. The research questions focus on how satisfied these workers are with the services and programs provided by TAA. Focus groups and survey instrument results indicate these workers found TAA services and processes cumbersome and time- consuming and actually had the effect of discouraging their education, training, and self- employment. The consequences of their dislocation as it relates to TAA experiences are increased frustration and dissatisfaction with the TAA program. Serious consideration for TAA policy changes should be deemed of utmost importance.

Thioacetamide-induced changes in the body weight, kidney weight and the total nucleic acids content of kidney of mouse

International Nuclear Information System (INIS)

Shakoori, Abdul Rauf; Ashraf, Fauzia.

1976-01-01

Effects of thioacetamide (TAA) on the body weight, kidney weight and the total nucleic acids content of kidney of mouse were studied. TAA 1% and 2% solutions were injected intraperitoneally, twice with an interval of 24 hours in two different batches of male mice. In this way one batch received a total dose of 100 mg TAA/Kg body wt. while the other got a total dose of 200 mg TAA/Kg. Both the body as well as kidney weights decrease after TAA treatment. A total dose of 200 mg/Kg is a stronger inhibitor of growth as compared with that of 100 mg/Kg. The nucleic acids content show an increase after the drug treatment. The ribonucleic acid content of kidney increased from an average value of 4.30+0.14 mg/g kidney to 4.60+-0.22 mg/g kidney after 1% TAA treatment. The increase in 2% TAA treated mice is slightly more prominent. The deoxyribonucleic acid (DNA) content of kidney are likewise affected. After an initial increase in 1% TAA-treated animals, the DNA content gradually fall down to normal control values. Administration of 2% TAA solution causes an average increase of 21% i.e. from 1.93+-0.19 mg/g kidney wt to 2.26+-0.23 mg/g kidney wt. The size of cell, nucleus and nucleolus also increased after drug treatment, which mainly occurred during the first 24 hours of the post-treatment period

A chemically modified [alpha]-amylase with a molten-globule state has entropically driven enhanced thermal stability

Energy Technology Data Exchange (ETDEWEB)

Siddiqui, Khawar Sohail; Poljak, Anne; De Francisci, Davide; Guerriero, Gea; Pilak, Oliver; Burg, Dominic; Raftery, Mark J.; Parkin, Don M.; Trewhella, Jill; Cavicchioli, Ricardo (Sydney); (New South)

2010-11-15

The thermostability properties of TAA were investigated by chemically modifying carboxyl groups on the surface of the enzyme with AMEs. The TAA{sub MOD} exhibited a 200% improvement in starch-hydrolyzing productivity at 60 C. By studying the kinetic, thermodynamic and biophysical properties, we found that TAA{sub MOD} had formed a thermostable, MG state, in which the unfolding of the tertiary structure preceded that of the secondary structure by at least 20 C. The X-ray crystal structure of TAA{sub MOD} revealed no new permanent interactions (electrostatic or other) resulting from the modification. By deriving thermodynamic activation parameters of TAA{sub MOD}, we rationalised that thermostabilisation have been caused by a decrease in the entropy of the transition state, rather than being enthalpically driven. Far-UV CD shows that the origin of decreased entropy may have arisen from a higher helical content of TAA{sub MOD}. This study provides new insight into the intriguing properties of an MG state resulting from the chemical modification of TAA.

Student Trade Missions: An Experiential Learning Opportunity

Science.gov (United States)

Audet, Josée; Marcotte, Geneviève

2018-01-01

In response to the criticisms addressed to business schools, teaching formulas that foster experiential learning are increasingly being put forward. The Missions Commerciales de l'Université Laval (MCUL--Université Laval Trade Missions) is a training program designed to foster experiential learning. This program extends over an entire academic…

Continuous supersonic plasma wind tunnel

DEFF Research Database (Denmark)

Andersen, S.A.; Jensen, Vagn Orla; Nielsen, P.

1968-01-01

The B field configuration of a Q-device has been modified into a magnetic Laval nozzle. Continuous supersonic plasma flow is observed with M≈3......The B field configuration of a Q-device has been modified into a magnetic Laval nozzle. Continuous supersonic plasma flow is observed with M≈3...

Sophie D'Amours | IDRC - International Development Research ...

International Development Research Centre (IDRC) Digital Library (Canada)

2017-06-01

Sophie became Université Laval's first-ever woman rector on June 1, 2017. A professor in the university's Department of Mechanical Engineering since 1995, she also served as vice-rector of research and innovation from 2012–2015. During her mandate as vice-rector, she successfully led Université Laval's Sentinel North ...

Vector prime/protein boost vaccine that overcomes defects acquired during aging and cancer

DEFF Research Database (Denmark)

Tang, Y.; Akbulut, H.; Maynard, J.

2006-01-01

We showed that the Ad-sig-TAA/ecdCD40L vaccine induces a tumor suppressive immune response to the hMUC-1 and rH2N tumor-associated self Ags (TAA) and to the Annexin A1 tumor vascular Ag, even in mice in which anergy exists to these Ags. When the TAA/ecdCD40L protein is given s.c. as a boost...... following the Ad-sig-TAA/ecdCD40L vector, the levels of the TAA-specific CD8 T cells and Abs increase dramatically over that seen with vector alone, in young (2-mo-old) as well as old (18-mo-old) mice. The Abs induced against hMUC-1 react with human breast cancer. This vaccine also induces a 4-fold...... decrement of negative regulatory CD4CD25FOXP3-T cells in the tumor tissue of 18-mo-old mice. These results suggest that the Ad-sig-TAA/ecdCD40L vector prime-TAA/ecdCD40L protein boost vaccine platform may be valuable in reducing postsurgery recurrence in a variety of epithelial neoplasms....

Bio-chemo-mechanics of thoracic aortic aneurysms.

Science.gov (United States)

Wagenseil, Jessica E

2018-03-01

Most thoracic aortic aneurysms (TAAs) occur in the ascending aorta. This review focuses on the unique bio-chemo-mechanical environment that makes the ascending aorta susceptible to TAA. The environment includes solid mechanics, fluid mechanics, cell phenotype, and extracellular matrix composition. Advances in solid mechanics include quantification of biaxial deformation and complex failure behavior of the TAA wall. Advances in fluid mechanics include imaging and modeling of hemodynamics that may lead to TAA formation. For cell phenotype, studies demonstrate changes in cell contractility that may serve to sense mechanical changes and transduce chemical signals. Studies on matrix defects highlight the multi-factorial nature of the disease. We conclude that future work should integrate the effects of bio-chemo-mechanical factors for improved TAA treatment.

Chemoprotective effect of omega-3 fatty acids on thioacetamide induced hepatic fibrosis in male rats

Directory of Open Access Journals (Sweden)

Atef M. Al-Attar

2017-05-01

Full Text Available The current study was designed to investigate the possible protective effect of omega-3 fatty acids from fish oil on hepatic fibrosis induced by thioacetamide (TAA in male rats. The experimental animals were divided into four groups. The first group was received saline solution and served as control. The second group was given 250 mg/kg body weight of TAA. The third group was treated with omega-3 fatty acids and TAA. The fourth group was given saline solution and supplemented with omega-3 fatty acids. Treatment of rats with TAA for three and six weeks resulted in a significant decrease in body weight gain, while the value of liver/body weight ratio was statistically increased. Furthermore, the levels of serum alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, gamma glutamyl transferase and total bilirubin were significantly increased. After three weeks of exposure to only TAA, liver sections showed an abnormal morphology characterized by noticeable fibrosis with the extracellular matrix collagen contents and damage of liver cells’ structure. Liver sections from rats treated with only TAA for six weeks revealed an obvious increase in extracellular matrix collagen content and bridging fibrosis. Treating TAA-intoxicated rats with omega-3 fatty acids significantly attenuated the severe physiological and histopathological changes. Finally, the present investigation suggests that omega-3 fatty acids could act against hepatic fibrosis induced by TAA due to its antioxidant properties, thus supporting its use in hepatic fibrosis therapy.

Promoter-region hypermethylation and expression downregulation of Yy1 (Yin yang 1) in preneoplastic liver lesions in a thioacetamide rat hepatocarcinogenesis model

International Nuclear Information System (INIS)

Abe, Hajime; Ogawa, Takashi; Wang, Liyun; Kimura, Masayuki; Tanaka, Takeshi; Morita, Reiko; Yoshida, Toshinori; Shibutani, Makoto

2014-01-01

Thioacetamide (TAA) has been used to develop a rodent model for hepatocarcinogenesis. To determine the genes with epigenetic modifications in early hepatocarcinogenesis, we did a genome-wide scan for hypermethylated promoter regions using CpG island microarrays in TAA-promoted rat liver tissue. Eight genes were selected based on the microarray profile; of these, Yy1 and Wdr45b were confirmed to be hypermethylated by methylation-specific polymerase chain reaction (PCR) and pyrosequencing and downregulated by real-time reverse transcription PCR. Non-neoplastic liver cells had nuclear Yy1 immunoreactivity, while preneoplastic foci with glutathione S-transferase placental form (GST-P) immunoreactivity had decreased Yy1 immunoreactivity. The incidence of these foci was proportional to the dose of TAA administered. Co-expression analysis of gene products downstream of Yy1 revealed increased nuclear phospho-c-Myc + foci as well as nuclear and cytoplasmic p21 Cip1+ foci in Yy1 − or GST-P + foci in response to TAA-promotion dose. Although the absolute number of cells was low, the incidence of death receptor 5 − foci was increased in Yy1 − foci in proportion to the TAA dose. Yy1 − /GST-P + foci revealed a higher number of proliferating cell nuclear antigen (PCNA)-immunoreactive cells than Yy1 + /GST-P + foci, while cleaved caspase-3 + cells were unchanged between Yy1 – /GST-P + and Yy1 + /GST-P + foci. In the case of Wdr45b, most GST-P + foci were Wdr45b – and were not increased by TAA promotion. These results suggest involvement of Yy1 in the epigenetic gene regulation at the early stages of TAA promoted cell proliferation and concomitant cell cycle arrest in preneoplastic lesions. - Highlights: • Epigenetically downregulated genes were searched in TAA-promnoted rat livers. • Yy1 and Wdr45b showed promoter-region hypermethylation and mRNA downregulation. • TAA promoted increase of preneoplastic Yy1 – /GST-P + foci showing high proliferation. • TAA

Muusikamaailm : Kuhmo festival 30. korda. Ernst Haefliger - 80. Esmakordne pianistide konkurss. Lincoln Centeri festival. Promenaadikontserdid algavad täna / Priit Kuusk

Index Scriptorium Estoniae

Kuusk, Priit, 1938-

1999-01-01

Soomes toimuvast Kuhmo kammermuusikafestivalist. E. Haefligeri lauljateest. Saksamaal toimunud Seileri fondi pianistide konkursist. Lincoln Centeri festivalist New Yorgis. Kontsertmuusikafestivalist "Promenaadikontserdid Londoni Royal Albert Hallis"

Muusikamaailm : Lihavõttemuusikat siit ja sealt. Los Angelese Ooperi plaanid. Bayreuthi tuleb Eva Wagner

Index Scriptorium Estoniae

2001-01-01

Salzburgi lihavõttefestivalist, lihavõttekavast New Yorgi Metropolitan Operas ja Roomas. Tulevikukavadest Los Angelese Ooperis. Bayreuthi ooerpifestivali uueks kunstiliseks juhiks valiti E.Wagner-Pasquier

The Myth of the Texas Miracle in Education

Directory of Open Access Journals (Sweden)

Walt Haney

2000-08-01

Full Text Available I summarize the recent history of education reform and statewide testing in Texas, which led to introduction of the Texas Assessment of Academic Skills (TAAS in 1990-91. A variety of evidence in the late 1990s led a number of observers to conclude that the state of Texas had made near miraculous progress in reducing dropouts and increasing achievement. The passing scores on TAAS tests were arbitrary and discriminatory. Analyses comparing TAAS reading, writing and math scores with one another and with relevant high school grades raise doubts about the reliability and validity of TAAS scores. I discuss problems of missing students and other mirages in Texas enrollment statistics that profoundly affect both reported dropout statistics and test scores. Only 50% of minority students in Texas have been progressing from grade 9 to high school graduation since the initiation of the TAAS testing program. Since about 1982, the rates at which Black and Hispanic students are required to repeat grade 9 have climbed steadily, such that by the late 1990s, nearly 30% of Black and Hispanic students were "failing" grade 9. Cumulative rates of grade retention in Texas are almost twice as high for Black and Hispanic students as for White students. Some portion of the gains in grade 10 TAAS pass rates are illusory. The numbers of students taking the grade 10 tests who were classified as "in special education" and hence not counted in schools' accountability ratings nearly doubled between 1994 and 1998. A substantial portion of the apparent increases in TAAS pass rates in the 1990s are due to such exclusions. In the opinion of educators in Texas, schools are devoting a huge amount of time and energy preparing students specifically for TAAS, and emphasis on TAAS is hurting more than helping teaching and learning in Texas schools, particularly with at-risk students, and TAAS contributes to retention in grade and dropping out. Five different sources of evidence about

Celecoxib ameliorates portal hypertension of the cirrhotic rats through the dual inhibitory effects on the intrahepatic fibrosis and angiogenesis.

Science.gov (United States)

Gao, Jin-Hang; Wen, Shi-Lei; Yang, Wen-Juan; Lu, Yao-Yao; Tong, Huan; Huang, Zhi-Yin; Liu, Zhang-Xu; Tang, Cheng-Wei

2013-01-01

Increased intra-hepatic resistance to portal blood flow is the primary factor leading to portal hypertension in cirrhosis. Up-regulated expression of cyclooxygenase-2 (COX-2) in the cirrhotic liver might be a potential target to ameliorate portal hypertension. To verify the effect of celecoxib, a selective inhibitor of COX-2, on portal hypertension and the mechanisms behind it. Cirrhotic liver model of rat was established by peritoneal injection of thiacetamide (TAA). 36 rats were randomly assigned to control, TAA and TAA+celecoxib groups. Portal pressures were measured by introduction of catheters into portal vein. Hepatic fibrosis was assessed by the visible hepatic fibrotic areas and mRNAs for collagen III and α-SMA. The neovasculature was determined by hepatic vascular areas, vascular casts and CD31 expression. Expressions of COX-2, vascular endothelial growth factor (VEGF), VEGF receptor-2 (VEGFR-2) and related signal molecules were quantitated. Compared with TAA group, the portal pressure in TAA+celecoxib group was significantly decreased by 17.8%, pportal venules. The data of fibrotic areas, CD31expression, mRNA levels of α-SMA and collagen III in TAA+celecoxib group were much lower than those in TAA group, pprotein levels of VEGF, VEGFR-2 and COX-2 induced by TAA was significantly inhibited after celecoxib treatment. The expressions of prostaglandin E2 (PGE2), phosphorylated extracellular signal-regulated kinase (p-ERK), hypoxia-inducible factor-1α (HIF-1α), and c-fos were also down-regulated after celecoxib treatment. Long term administration of celecoxib can efficiently ameliorate portal hypertension in TAA rat model by its dual inhibitory effects on the intrahepatic fibrosis and angiogenesis. The anti-angiogenesis effect afforded by celecoxib may attribute to its modulation on VEGF/VEGFR-2 through the down-regulation of integrated signal pathways involving PGE2- HIF-1α- VEGF and p-ERK- c-fos- VEGFR-2.

Cell wall α-1,3-glucan prevents α-amylase adsorption onto fungal cell in submerged culture of Aspergillus oryzae.

Science.gov (United States)

Zhang, Silai; Sato, Hiroki; Ichinose, Sakurako; Tanaka, Mizuki; Miyazawa, Ken; Yoshimi, Akira; Abe, Keietsu; Shintani, Takahiro; Gomi, Katsuya

2017-07-01

We have previously reported that α-amylase (Taka-amylase A, TAA) activity disappears in the later stage of submerged Aspergillus oryzae culture as a result of TAA adsorption onto the cell wall. Chitin, one of the major components of the cell wall, was identified as a potential factor that facilitates TAA adsorption. However, TAA adsorption only occurred in the later stage of cultivation, although chitin was assumed to be sufficiently abundant in the cell wall regardless of the submerged culture period. This suggested the presence a factor that inhibits TAA adsorption to the cell wall in the early stage of cultivation. In the current study, we identified α-1,3-glucan as a potential inhibiting factor for TAA adsorption. We constructed single, double, and triple disruption mutants of three α-1,3-glucan synthase genes (agsA, agsB, and agsC) in A. oryzae. Growth characteristics and cell wall component analysis of these disruption strains showed that AgsB plays a major role in α-1,3-glucan synthesis. In the ΔagsB mutant, TAA was adsorbed onto the mycelium in all stages of cultivation (early and later), and the ΔagsB mutant cell walls had a significantly high capacity for TAA adsorption. Moreover, the α-1,3-glucan content of the cell wall prepared from the wild-type strain in the later stage of cultivation was markedly reduced compared with that in the early stage. These results suggest that α-1,3-glucan is a potential inhibiting factor for TAA adsorption onto the cell wall component, chitin, in the early stage of submerged culture in A. oryzae. Copyright © 2017 The Society for Biotechnology, Japan. Published by Elsevier B.V. All rights reserved.

Na meste razrushennogo Vsemirnogo torgovogo tsentra

Index Scriptorium Estoniae

2003-01-01

New Yorgi Maailma Kaubandusekeskuse (WTC) taastamisprojektide konkursi kahest paremast tööst: arhitekt Daniel Libeskindi ja rahvusvahelise arhitektide grupi THINK projekt "Ülemaailmne kultuurikeskus"

Wallpaperi lemmikud 2007

Index Scriptorium Estoniae

2007-01-01

Ajakirja "Wallpaper" lemmikhooned: New Yorgi Morgani muuseumi ja raamatukogu juurdeehitus (arhitekt Renzo Piano), eramaja Baron House Rootsis (arhitekt John Pawson), treppmaja Portugalis (arhitekt Alvaro Siza)

Mark Kostabi soovib muuta inimesi õnnelikumaks / Kalev Mark Kostabi

Index Scriptorium Estoniae

Kostabi, Kalev Mark, 1960-

2008-01-01

Kalev Mark Kostabi oma sisekujunduslikest eelistustest, ameeriklaste ja itaallaste kodude sisekujunduse erinevustest, kunstist kui ruumikujunduse ühest osast, oma New Yorgi ja Rooma korterite kujundusest

Merrill Lynch kavandab äridelegatsiooni visiiti Eestisse

Index Scriptorium Estoniae

2000-01-01

Investeerimispanga Merrill Lynch eestvedamisel kavandatakse mais ärimeeste visiiti Eestisse, ütles Jüri Mõis, kes viibis New Yorgis toimunud Maailmapanga seminaril "Omavalitsused rahvusvahelistel kapitaliturgudel"

Means on scattered compacta

Czech Academy of Sciences Publication Activity Database

Banakh, T.; Bonnet, R.; Kubiś, Wieslaw

2014-01-01

Roč. 2, č. 1 (2014), s. 5-10 ISSN 2299-3231 R&D Projects: GA ČR(CZ) GAP201/12/0290 Institutional support: RVO:67985840 Keywords : scattered compact space * mean operation Subject RIV: BA - General Mathematics http://www.degruyter.com/view/j/taa.2014.2.issue-1/taa-2014-0002/taa-2014-0002.xml

75 FR 14192 - Grant of Individual Exemption Involving Ford Motor Company, Located in Detroit, MI

Science.gov (United States)

2010-03-24

... lieu of some or all of the investments in the TAA, (b) two promissory notes issued by Ford in an... commenter's concerns, Ford contends that the fundamental deal reached by the parties is that Ford will make... investment return on the TAA assets paid to Ford in exchange for the TAA Note. Based on year-end returns...

Eskiz memoriala na meste VTTS v Nju-Jorke

Index Scriptorium Estoniae

2004-01-01

New Yorgi Maailma Kaubanduskeskuse memoriaali võidukavandiks tunnistati Ameerikas elava iisraeli arhitekti Michael Aradi ja ameerika maastikuarhitekti Peter Walkeri projekt "Peegeldades kadunut". Memoriaali kirjeldus, 3 ill

Unistuste õhuloss juustumaal Šveitsis / Ivar-Kristjan Hein

Index Scriptorium Estoniae

Hein, Ivar-Kristjan

2002-01-01

New Yorgi arhitektide Elizabeth Dilleri (46) ja Ricardo Scofidio (65) looming Neuchateli järvel - kunstlik pilv, kuhu saab siseneda. Arhitektid eksperimenteerivad ruumikasutuse erinevate võimalustega

Hooaeg New Yorgis / Jaak Rähesoo

Index Scriptorium Estoniae

Rähesoo, Jaak, 1941-

1999-01-01

Joseph Chaikini, Samuel Becketti ja Sam Shepardi näidendite lavastused. Ameerika teatriuuendajate Richard Foremani ja Lee Breueri lavastustest. Järg vt. nr. 3, lk. 33-40, 96; nr. 4, lk. 33-42; nr. 5, lk. 37-45

Uus kunstiskandaal New Yorgis / Neeme Raud

Index Scriptorium Estoniae

Raud, Neeme, 1969-

2001-01-01

Mustanahalise naiskunstniku Renee Coxi fotopannoo "Yo Mama's Last Supper", kus Kristuse asemel on lauas alasti neegrinaine. Linnapea Rudolph Giuliani tahab moodustada "sündsuse komisjoni", kes otsustaks eksponeeritavate kunstiteoste sobivuse üle

Effects of curcumin on angiotensin-converting enzyme gene expression, oxidative stress and anti-oxidant status in thioacetamide-induced hepatotoxicity.

Science.gov (United States)

Fazal, Yumna; Fatima, Syeda Nuzhat; Shahid, Syed Muhammad; Mahboob, Tabassum

2015-12-01

This study aimed to evaluate the protective effects of curcumin on angiotensin-converting enzyme (ACE) gene expression, oxidative stress and anti-oxidant status in thioacetamide (TAA)-induced hepatotoxicity in rats. Total 32 albino Wistar rats (male, 200-250 g) were divided into six groups (n=8). Group 1: untreated controls; Group 2: received TAA (200 mg/kg body weight (b.w.); i.p.) for 12 weeks; Group 3: received curcumin (75 mg/kg b.w.) for 24 weeks; Group 4: received TAA (200 mg/kg b.w.; i.p.) for 12 weeks+curcumin (75 mg/kg b.w.) for 12 weeks. A significantly higher ACE gene expression was observed in TAA-induced groups as compared with control, indicating more synthesis of ACE proteins. Treatment with curcumin suppressed ACE expression in TAA liver and reversed the toxicity produced. TAA treatment results in higher lipid peroxidation and lower GSH, SOD and CAT than the normal, and this produces oxidative stress in the liver. Cirrhotic conditions were confirmed by serum enzymes (ALT, AST and ALP) as well as histopathological observations. Curcumin treatment reduced oxidative stress in animals by scavenging reactive oxygen species, protecting the anti-oxidant enzymes from being denatured and reducing the oxidative stress marker lipid peroxidation. Curcumin treatment restores hepatocytes, damaged by TAA, and protects liver tissue approaching cirrhosis. © The Author(s) 2014.

Can the TLR-4-Mediated Signaling Pathway Be “A Key Inflammatory Promoter for Sporadic TAA”?

Directory of Open Access Journals (Sweden)

Giovanni Ruvolo

2014-01-01

Full Text Available Thoracic aorta shows with advancing age various changes and a progressive deterioration in structure and function. As a result, vascular remodeling (VR and medial degeneration (MD occur as pathological entities responsible principally for the sporadic TAA onset. Little is known about their genetic, molecular, and cellular mechanisms. Recent evidence is proposing the strong role of a chronic immune/inflammatory process in their evocation and progression. Thus, we evaluated the potential role of Toll like receptor- (TLR- 4-mediated signaling pathway and its polymorphisms in sporadic TAA. Genetic, immunohistochemical, and biochemical analyses were assessed. Interestingly, the rs4986790 TLR4 polymorphism confers a higher susceptibility for sporadic TAA (OR=14.4, P=0.0008 and it represents, together with rs1799752 ACE, rs3918242 MMP-9, and rs2285053 MMP-2 SNPs, an independent sporadic TAA risk factor. In consistency with these data, a significant association was observed between their combined risk genotype and sporadic TAA. Cases bearing this risk genotype showed higher systemic inflammatory mediator levels, significant inflammatory/immune infiltrate, a typical MD phenotype, lower telomere length, and positive correlations with histopatological abnormalities, hypertension, smoking, and ageing. Thus, TLR4 pathway should seem to have a key role in sporadic TAA. It might represent a potential useful tool for preventing and monitoring sporadic TAA and developing personalized treatments.

Identification of potential cell wall component that allows Taka-amylase A adsorption in submerged cultures of Aspergillus oryzae.

Science.gov (United States)

Sato, Hiroki; Toyoshima, Yoshiyuki; Shintani, Takahiro; Gomi, Katsuya

2011-12-01

We observed that α-amylase (Taka-amylase A; TAA) activity in the culture broth disappeared in the later stage of submerged cultivation of Aspergillus oryzae. This disappearance was caused by adsorption of TAA onto the cell wall of A. oryzae and not due to protein degradation by extracellular proteolytic enzymes. To determine the cell wall component(s) that allows TAA adsorption efficiently, the cell wall was fractionated by stepwise alkali treatment and enzymatic digestion. Consequently, alkali-insoluble cell wall fractions exhibited high levels of TAA adsorption. In addition, this adsorption capacity was significantly enhanced by treatment of the alkali-insoluble fraction with β-glucanase, which resulted in the concomitant increase in the amount of chitin in the resulting fraction. In contrast, the adsorption capacity was diminished by treating the cell wall fraction with chitinase. These results suggest that the major component that allows TAA adsorption is chitin. However, both the mycelium and the cell wall demonstrated the inability to allow TAA adsorption in the early stage of cultivation, despite chitin content in the cell wall being identical in both early and late stages of cultivation. These results suggest the existence of unidentified factor(s) that could prevent the adsorption of TAA onto the cell wall. Such factor(s) is most likely removed or diminished from the cell wall following longer cultivation periods.

"Linn" taas Theatrumis

Index Scriptorium Estoniae

2009-01-01

Theatrumis võib veel mõned korrad oktoobris vaadata sel aastal nii parima lavastaja (Lembit Peterson) kui ka meesnäitleja (Marius Peterson) kategoorias teatripreemia pälvinud lavastust - Jevgeni Griškovetsi "Linna"

Uffizi taas avatud

Index Scriptorium Estoniae

1999-01-01

Firenzes avas pärast viit aastat kestnud restaureerimist uksed Uffizi Galerii.1560. a. asutatud muuseumis näidatakse nüüd peale põhiväljapaneku ka varem peamiselt hoidlates asunud freskosid, maale ja skulptuure.

Oksanenile taas preemia

Index Scriptorium Estoniae

2010-01-01

Sofi Oksaneni romaan "Puhastus" pälvis Euroopa Raamatu auhinna (European Book Prize), tunnustati ka itaallast Roberto Savianot essee "Kaunitar ja koletis" eest ("La bellezza e l'inferno. Scritti 2004-2009")

Rolling Stonesi kinokontsert kannab toorest rokiväge / Maris Meiessaar

Index Scriptorium Estoniae

Meiessaar, Maris

2009-01-01

Martin Scorsese muusikalisest dokumentaalfilmist "Shine a Light - Valgus peale" (USA-Suurbritannia, 2008), mille keskmes on 2006. a. New Yorgi Beaconi teatris toimunud briti ansambli Rolling Stones kontsert

ACTION OF VITAMIN E ON EXPERIMENTAL SEVERE ACUTE LIVER FAILURE.

Science.gov (United States)

Miguel, Fabiano Moraes; Schemitt, Elizângela Gonçalves; Colares, Josieli Raskopf; Hartmann, Renata Minuzzo; Morgan-Martins, Maria Isabel; Marroni, Norma Possa

2017-01-01

Severe Acute Liver Failure (ALF) is a life-threatening clinical syndrome characterized by hepatocyte necrosis, loss of hepatic architecture, and impairment of liver functions. One of the main causes of ALF is hepatotoxicity from chemical agents, which damage hepatocytes and result in increase of reactive oxygen species. The vitamin E isoform is the one with the strongest biological antioxidant activity. To evaluate the antioxidant effect of vitamin E in this ALF model. We used 56 rats (mean weight of 300 g) divided into eight groups, four groups assessed at 24 hours and 4 assessed at 48 hours after induction: control group (CO); Vitamin E (Vit. E); Thioacetamide (TAA) and Thioacetamide + Vitamina E (TAA+Vit.E). Rats were submitted to injections of thioacetamide (400 mg/kg i.p.) at baseline and 8 hours later. Vitamin E (100 mg/kg ip) was administered 30 minutes after the second dose of thioacetamide. The 48-hour group rats received two additional doses of vitamin E (24h and 36h). At 24h or 48 hours after the administration of the first dose of TAA, rats were weighed and anesthetized and their blood sampled for evaluation of liver integrity through enzymes aspartate aminotransferase (AST) and alanine aminotransferase (ALT). Liver tissue was sampled for assessment of lipid peroxidation (LPO) by the technique TBARS, antioxidant enzymes SOD, CAT, GPx and GST activity, levels of the NO 2 /NO 3 and histology by H&E in two times. The results were expressed as mean ± standard deviation and statistically analyzed by ANOVA followed by Student-Newman-Keuls, with P E, we observed a reduction in liver enzymes AST (U/L) (101.32±19.45 in 24 hours and 97.85±29.65 in 48 hours) related to the TAA group (469.56± 0.69 in 24 hours and 598.23±55.45 in 48 hours) and ALT (U/L) (76.59±8.56 in 24 hours and 68.47±6.49 in 48 hours) compared to the TAA group (312.21±10.23 in 24 hours and 359.15±17.58 in 48 hours). There was a reduction of LPO (nmol/mg Prot) in the TAA+Vit.E group (0

A Trimeric Lipoprotein Assists in Trimeric Autotransporter Biogenesis in Enterobacteria*

Science.gov (United States)

Grin, Iwan; Hartmann, Marcus D.; Sauer, Guido; Hernandez Alvarez, Birte; Schütz, Monika; Wagner, Samuel; Madlung, Johannes; Macek, Boris; Felipe-Lopez, Alfonso; Hensel, Michael; Lupas, Andrei; Linke, Dirk

2014-01-01

Trimeric autotransporter adhesins (TAAs) are important virulence factors of many Gram-negative bacterial pathogens. TAAs form fibrous, adhesive structures on the bacterial cell surface. Their N-terminal extracellular domains are exported through a C-terminal membrane pore; the insertion of the pore domain into the bacterial outer membrane follows the rules of β-barrel transmembrane protein biogenesis and is dependent on the essential Bam complex. We have recently described the full fiber structure of SadA, a TAA of unknown function in Salmonella and other enterobacteria. In this work, we describe the structure and function of SadB, a small inner membrane lipoprotein. The sadB gene is located in an operon with sadA; orthologous operons are only found in enterobacteria, whereas other TAAs are not typically associated with lipoproteins. Strikingly, SadB is also a trimer, and its co-expression with SadA has a direct influence on SadA structural integrity. This is the first report of a specific export factor of a TAA, suggesting that at least in some cases TAA autotransport is assisted by additional periplasmic proteins. PMID:24369174

Effects of aspirin and enoxaparin in a rat model of liver fibrosis.

Science.gov (United States)

Li, Chen-Jie; Yang, Zhi-Hui; Shi, Xiao-Liu; Liu, De-Liang

2017-09-21

To examine the effects of aspirin and enoxaparin on liver function, coagulation index and histopathology in a rat model of liver fibrosis. METHODS Forty-five male Sprague-Dawley rats were randomly divided into the control group (n = 5) and model group (n = 40). Thioacetamide (TAA) was used to induce liver fibrosis in the model group. TAA-induced fibrotic rats received TAA continuously (n = 9), TAA + low-dose aspirin (n = 9), TAA + high-dose aspirin (n = 9) or TAA + enoxaparin (n = 9) for 4 wk. All rats were euthanized after 4 wk, and both hematoxylin-eosin and Masson staining were performed to observe pathological changes in liver tissue. Liver fibrosis was assessed according to the METAVIR score. Compared with untreated cirrhotic controls, a significant improvement in fibrosis grade was observed in the low-dose aspirin, high-dose aspirin and enoxaparin treated groups, especially in the high-dose aspirin treated group. Alanine aminotransferase and total bilirubin were higher, albumin was lower and both prothrombin time and international normalized ratio were prolonged in the four treatment groups compared to controls. No significant differences among the four groups were observed. Aspirin and enoxaparin can alleviate liver fibrosis in this rat model.

Any : üheksakümnendate projekt / Triin Ojari

Index Scriptorium Estoniae

Ojari, Triin, 1974-

2000-01-01

1990. a. New Yorgis loodud korporatsiooni 'Anyone' poolt juhitud konverentse, diskussioone ja publikatsioone ('ANY Magazine', aastaraamatud, raamatuseeria 'Writind Architecture') hõlmavast arhitektuuriprojektist. Any viimasest konverentsist 2000. a. juunis

Michael Bloomberg ähvardab USA valimised "ära rikkuda" / Heiki Suurkask

Index Scriptorium Estoniae

Suurkask, Heiki, 1972-

2008-01-01

New Yorgi praegune linnapea Michael Bloomberg võib kolmanda kandidaadina sekkuda presidendikandidaatide valimiskampaaniasse, probleem on aga tema vähene tuntus. Lisa: Seni on riigipeakoha jaganud kaks suurparteid

Muusikamaailm : Suvefestivalid täies hoos / Priit Kuusk

Index Scriptorium Estoniae

Kuusk, Priit, 1938-

2001-01-01

Suvefestivalidest : Aix-en-Provence'i festivalist, Londoni "Promenaadikontsertidest", Spoleto "Kahe maailma festivalist", Sapporo "Pacific Music Festival'ist", Bregenzi festivalist, New Yorgi Lincoln Center'i festivalist ja Verbieri festivalist

Mramornaja Britni borjotsja s abortami

Index Scriptorium Estoniae

2006-01-01

Ameerika skulptor Daniel Edwards astub abordi vastu sünnitava Britney Spearsi realistliku skulptuuriga "Monument elu poolt : Sean Prestoni sünd". Eksponeeritakse New Yorgis Capla Kestingi kunstigaleriis

Indrek Kasela, Hamlet ärimaailmas / Indrek Kasela ; intervjueerinud Priit Pullerits ; kommenteerinud Maarja Neilvelt

Index Scriptorium Estoniae

Kasela, Indrek, 1971-

2010-01-01

Ettevõtja, kino Sõprus taasavaja ning Premia börsile viija Indrek Kasela oma tegevusest fondihaldurina, New Yorgi ülikoolis saadud kogemustest, Eesti ühiskonnakorralduses vaja minevatest muutustest

Anna ajas edasi : lähenemine ajalisele arhitektuurile ja muutuste arhitektuurile = Feed it forward : an approach towards time-based design and an architecture of change / Michael Hensel

Index Scriptorium Estoniae

Hensel, Michael

2002-01-01

Näited: Ocean North'i eskiis Inimsusküsimuste Maailmakeskusele New Yorgis, Nasrin Kalbasi kohandatava arhitektuuri projekt, Achim Mengese projekt - uurib alternatiivset lähenemist agrotootmisele Westlandis Hollandis

Teater kinos või kino teatris? "Salome" juhtum / Rein Veidemann

Index Scriptorium Estoniae

Veidemann, Rein, 1946-

2008-01-01

Ooper kinolinal : Richard Strauss. "Salome". Dirigent Patrick Summers, lavastaja Jürgen Flimm. New Yorgi Metropolitan Opera etenduse otseülekanne 11. oktoobril Tallinna kobarkinos ja Tartu kinos Ekraan

Celecoxib ameliorates portal hypertension of the cirrhotic rats through the dual inhibitory effects on the intrahepatic fibrosis and angiogenesis.

Directory of Open Access Journals (Sweden)

Jin-Hang Gao

Full Text Available BACKGROUND: Increased intra-hepatic resistance to portal blood flow is the primary factor leading to portal hypertension in cirrhosis. Up-regulated expression of cyclooxygenase-2 (COX-2 in the cirrhotic liver might be a potential target to ameliorate portal hypertension. OBJECTIVE: To verify the effect of celecoxib, a selective inhibitor of COX-2, on portal hypertension and the mechanisms behind it. METHODS: Cirrhotic liver model of rat was established by peritoneal injection of thiacetamide (TAA. 36 rats were randomly assigned to control, TAA and TAA+celecoxib groups. Portal pressures were measured by introduction of catheters into portal vein. Hepatic fibrosis was assessed by the visible hepatic fibrotic areas and mRNAs for collagen III and α-SMA. The neovasculature was determined by hepatic vascular areas, vascular casts and CD31 expression. Expressions of COX-2, vascular endothelial growth factor (VEGF, VEGF receptor-2 (VEGFR-2 and related signal molecules were quantitated. RESULTS: Compared with TAA group, the portal pressure in TAA+celecoxib group was significantly decreased by 17.8%, p<0.01. Celecoxib treatment greatly reduced the tortuous hepatic portal venules. The data of fibrotic areas, CD31expression, mRNA levels of α-SMA and collagen III in TAA+celecoxib group were much lower than those in TAA group, p<0.01. Furthermore, the up-regulation of hepatic mRNA and protein levels of VEGF, VEGFR-2 and COX-2 induced by TAA was significantly inhibited after celecoxib treatment. The expressions of prostaglandin E2 (PGE2, phosphorylated extracellular signal-regulated kinase (p-ERK, hypoxia-inducible factor-1α (HIF-1α, and c-fos were also down-regulated after celecoxib treatment. CONCLUSIONS: Long term administration of celecoxib can efficiently ameliorate portal hypertension in TAA rat model by its dual inhibitory effects on the intrahepatic fibrosis and angiogenesis. The anti-angiogenesis effect afforded by celecoxib may attribute to its

Muusikamaailm : LPO kevadturnee. Tippmuusikud Berliinis. Uudiseid ooperimajadest / Priit Kuusk

Index Scriptorium Estoniae

Kuusk, Priit, 1938-

2001-01-01

LPO traditsioonilisest kevadturneest Euroopas. Berliini Musikbiennale'st. Uudiseid New Yorgi Metropolitan Operast, Washingtoni Ooperist, Chicago Lyric Operast, Londoni Royal Operast, Pariisi Chatelet' teatrist, Hollandi Ooperist ja Zürichi Ooperist

Muusikamaailm / Priit Kuusk

Index Scriptorium Estoniae

Kuusk, Priit, 1938-

2005-01-01

Milano La Scala alustas hooaega. "Ameerika tragöödia" New Yorgi Metis. Huddersfieldi festivalilt. Ricard Straussi päevad Dresdenis. Viiuldajate konkurss Helsingis. Haruldasi leide. Tunnustusi ja preemiaid

Prada postulaat = Prada Postulate / Martin Melioranski

Index Scriptorium Estoniae

Melioranski, Martin

2002-01-01

Hollandi arhitektide Rem Koolhaasi ja Ole Scheereni (Office for Metropolitan Architecture) projekteeritud Prada kauplusest SoHos New Yorgis. Infotehnoloogia: R. Koolhaas ja Markus Schaefer (AMO-Information technology). 13 ill.

Kokteilikuningas / Ilaria De Bartolomeis

Index Scriptorium Estoniae

De Bartolomeis, Ilaria

2008-01-01

Maailma hinnatuim baarmen Angus Winchester avaldas Gentlemanile hea dringi saladused ning koostas nimekirja maailma parimatest baaridest, mis asuvad Milanos, Bratislavas, Londonis, Melbourneþis ja New Yorgis. Lisaks kokteiliretseptid

Popkontsert terroriohvrite toetuseks

Index Scriptorium Estoniae

2001-01-01

Muusikakanal VH1, Cablevision ja Miramix Film korraldavad 20.oktoobril televisioonis otse ülekantava kontserdi Madison Square Gardenis New Yorgi terroriaktis hukkunute mälestuseks ja kannatada saanute toetuseks

Bagatellid : maailm / Mirjam Tally

Index Scriptorium Estoniae

Tally, Mirjam, 1976-

2007-01-01

New Yorgi Filharmoonikute hooaeg jätkub hiina solistidega. Heliplaadid mehhiko tenorilt Rolando Villazonilt. Skandaalid Soome Rahvusooperis. Philip Glass leidis tunnustust kodulinnas Baltimore'is. Rõõmurohke Grammyde aasta 2007

Dendritic cells for active anti-cancer immunotherapy: targeting activation pathways through genetic modification.

Science.gov (United States)

Breckpot, Karine; Escors, David

2009-12-01

Tumour immunotherapy has become a treatment modality for cancer, harnessing the immune system to recognize and eradicate tumour cells specifically. It is based on the expression of tumour associated antigens (TAA) by the tumour cells and aims at the induction of TAA-specific effector T cell responses, whilst overruling various mechanisms that can hamper the anti-tumour immune response, e.g. regulatory T cells (Treg). (Re-) activation of effector T cells requires the completion of a carefully orchestrated series of specific steps. Particularly important is the provision of TAA presentation and strong stimulatory signals, delivered by co-stimulatory surface molecules and cytokines. These can only be delivered by professional antigen-presenting cells, in particular dendritic cells (DC). Therefore, DC need to be loaded with TAA and appropriately activated. It is not surprising that an extensive part of DC research has focused on the delivery of both TAA and activation signals to DC, developing a one step approach to obtain potent stimulatory DC. The simultaneous delivery of TAA and activation signals is therefore the topic of this review, emphasizing the role of DC in mediating T cell activation and how we can manipulate DC for the pill-pose of enhancing tumour immunotherapy. As we gain a better understanding of the molecular and cellular mechanisms that mediate induction of TAA-specific T cells, rational approaches for the activation of T cell responses can be developed for the treatment of cancer.

Augmented hepatic injury followed by impaired regeneration in metallothionein-I/II knockout mice after treatment with thioacetamide

International Nuclear Information System (INIS)

Oliver, Jordan R.; Jiang, Sean; Cherian, M. George

2006-01-01

A previous study (Oliver, J.R., Mara, T.W., Cherian, M.G. 2005. Impaired hepatic regeneration in metallothionein-I/II knockout mice after partial hepatectomy. Exp. Biol. Med. 230, 61-67) has shown an impairment of liver regeneration following partial hepatectomy (PH) in metallothionein (MT)-I and MT-II gene knockout (MT-null) mice, thus suggesting a requirement for MT in cellular growth. The present study was undertaken to investigate whether MT may play a similar role in hepatic injury and regeneration after acute treatment with thioacetamide (TAA). Hepatotoxicity of TAA is caused by the generation of oxidative stress. TAA was injected ip to both wild-type (WT) and MT-null mice. Mice were killed at 6, 12, 24, 48, 60, and 72 h after injection of TAA (125 mg/kg) or 48 h after injection of saline (vehicle control), and different parameters of hepatic injury were measured. The levels of hepatic lipid peroxidation were increased at 12 h in both types of mice; however, lipid peroxidation was significantly less in WT mice than MT-null mice at 48 h after injection of TAA. Analysis of hepatic glutathione (GSH) levels after TAA injection showed depletion of GSH at 12 h in WT mice and at 6 h in MT-null mice; however, significantly more GSH was depleted early (6-24 h) in MT-null mice than WT mice. An increase in hepatic iron (Fe) levels was observed in both types of mice after injection of TAA, but Fe levels were significantly higher in MT-null mice than WT mice at 6-60 h. The levels of hepatic copper (Cu) and zinc (Zn) were significantly higher in WT mice than MT-null mice at 6-60 h for Cu, and at 24 h and 60 h for Zn, respectively. Histopathological examination showed hemorrhagic necrosis in the liver of both types of mice at 12-72 h, with hepatic injury being more prominent in MT-null mice than WT mice. The hepatic MT levels were increased in WT mice after injection of TAA, and were highest at 24-72 h. Immunohistochemical staining for MT in WT mice indicated the presence

Therapeutic assessment with an adolescent: choosing connections over substances.

Science.gov (United States)

Austin, Cynthia A; Krumholz, Lauren S; Tharinger, Deborah J

2012-01-01

This case study provides an in-depth example of a comprehensive therapeutic assessment with an adolescent (TA-A) and his parents. The TA-A addressed parental concerns about their son's drug experimentation as well as the adolescent's own private questions about his distinctiveness from others, all set against a backdrop of ongoing parental conflict and poor communication. The TA-A process and how it is specifically tailored to balance the needs of adolescents and their parents is discussed. Subsequently, each step of TA-A is illustrated through the case study. Research findings at the conclusion of the assessment and at follow-up indicated significant decreases in internalizing symptomology and school problems, increases in self-esteem and self-reliance, and improved family functioning as reported by the adolescent. At follow-up, the father spoke of developing a more assertive parenting approach and successful follow-through on recommendations. This case study provides a template for clinicians interested in conducting TA-A.

Effect of gibberellic acid on total antioxidant activity during Chenopodium rubrum L. ontogenesis invitro

Directory of Open Access Journals (Sweden)

Mitrović Aleksandra

2009-01-01

Full Text Available Total antioxidant activity (TAA represents the combined ability of diverse antioxidants present in a sample of plant material to scavenge free radicals. Chenopodium rubrum L. sel. 184 is a qualitatively short-day plant; as an early-flowering species, it is a suitable object for studying ontogenesis in vitro. We investigated the effect of GA3 (5 mg/l on TAA during C. rubrum ontogenesis under two different inductive photoperiodic regimes in vitro. Total antioxidant activ­ity does not change in different phases of C. rubrum ontogenesis under the same photoperiodic treatment. Exposure to continuous irradiation caused an increase of TAA in both C. rubrum plants and collected matured seeds. Gibberellic acid stimulated stem elongation, but did not affect leaf development or the number of matured seeds per plant, regardless of photoperiodic treatment; it induced a decrease of TAA in C. rubrum plants regardless of photoperiodic treatment or the phase of development, while it had no effect on TAA of matured seeds.

Na meste razrushennõh bashen-bliznetsov postrojat novõi torgovõi tsentr

Index Scriptorium Estoniae

2007-01-01

Maailma Kaubanduskeskuse kaksiktornide asemele New Yorgis ehitatakse Vabaduse torni kõrvale veel kolm pilvelõhkujat: Torn Kaks (arhitekt Norman Foster), Torn Kolm (arhitekt Richard Rogers), Torn Neli (arhitekt Fumihiko Maki)

Muusikamaailm : Messiaeni mälestusfestival. Masuri lahkumiskontserdid USAs. Kolmest kaotusest / Priit Kuusk

Index Scriptorium Estoniae

Kuusk, Priit, 1938-

2002-01-01

Olivier Messiaeni mälestusfestivalist "musik sehen, licht hören". Kurt Masur lahkub New Yorgi Filharmoonia orkestri peadirigendi ametist. Teated Xavier Montsalvatge, Dorothy DeLay ja Dzhansug Kahhidze surmast

Muusikamaailm : Aasta heliplaadid. Aastavahetus muusikalavadel. Aage Haugland surnud / Priit Kuusk

Index Scriptorium Estoniae

Kuusk, Priit, 1938-

2001-01-01

Financial Timesi kriitiku A. Clarki äramärgitud heliplaatidest aastast 2000. Aastavahetuse ooperietendustest ja kontsertidest New Yorgis, Washingtonis, Pariisis, Amsterdamis, Frankfurdis, Milanos, Londonis ja Barcelonas. Lühidalt A. Hauglandist

Postmodernistlikust teadusfantastikast = Postmodern science fiction / Märt Väljataga

Index Scriptorium Estoniae

Väljataga, Märt, 1965-

2010-01-01

New Yorgi ülikooli teoreetilise füüsika professor Alan Sokali 1994. aastal postmodernistlikust teadusest ilmunud paroodiaartiklist "Piire rikkudes: kvantgravitatsiooni hermeneutilise transformatsiooni poole" ja selle ümber tekkinud poleemikast

Düreri maal Eestis ehk Ristija Johannese eksirännakud = Dürer's painting in Estonia - St. John the Baptist's misguided travels / Kadi Polli

Index Scriptorium Estoniae

Polli, Kadi, 1973-

2003-01-01

Saksa maalikunstniku Albrecht Düreri lõpetamata jäänud altarimaalist pärnapuul - "Püha Onufrius" (Bremeni Kunsthalles), "Ristija Johannes" (Eesti Kunstimuuseumis), "Salvator Mundi" (New Yorgi Metropolitani muuseumis)

Aapo Puki fantastiline menu nii idas kui läänes / Ivo Parbus

Index Scriptorium Estoniae

Parbus, Ivo, 1959-

2004-01-01

New Yorgi kunstikeskus Art Renewal Center valis 2003. a. konkursil auhinna Honorable Mention laureaadiks Aapo Puki õlimaaliga "Natalja Sigarimajas". Suurbritannia Kuninglik Portreemaalijate Ühing eksponeerib maali oma aastanäitusel

GARLIC AMELIORATES THE HEPATOTOXIC EFFECT INDUCED BY THIOACETAMIDE IN FEMALE RATS

International Nuclear Information System (INIS)

OSMAN, H.F.; TAHA, M.S.

2008-01-01

The purpose of this study was to investigate the pretreatment effect of garlic on hepatotoxicity and oxidative stress induced by thioacetamide (TAA) in female albino rats.Sixty female adult albino rats were assigned equally into four groups; control group: animals without treatment, group ?: rats given daily oral dose of 250 mg/ kg garlic for 28 days, group ??: rats injected intraperitonealy by thioacetamide 20 mg ? kg for two weeks and group III: rats given 250 mg / kg garlic orally for 28 day followed by intrapertoneal injection of 20 mg / kg thioacetamide for two weeks. Liver enzymes were evaluated by measurements of AST, ALT and alkaline phosphatase and also trace elements (Cu and Zn) were estimated. Superoxide dismutase, glutathione peroxidase, malondialdehyde and thyroid hormones (T3 and T4) were assessed. Also, histological studies on liver and stomach were carried out. The results indicated that treatment with garlic significantly decreased liver enzymes (AST, ALT and ALP). Cu showed high significant increase in groups treated with garlic and also garlic + TAA, while Zn was increased significantly in TAA group. Superoxide dismutase (SOD) was increased significantly in group I while TAA decreased it significantly. Glutathione peroxidase was decreased significantly in group II while its level in group IV reached near the control value. Similarly, malondialdehyde was decreased significantly in garlic group and garlic ameliorated the thioacetamide effect in garlic + TAA group. The treatment with TAA led to significant increase in T3 and significant decrease in T4 hormones. Garlic ameliorated T3 level to reach the control level. Histologically, pre-treatment with garlic induced a prophylactic activity against the thioacetamide in liver and stomach tissues.According to the obtained results, it could be conclude that garlic treatment may act as antioxidant or pro-oxidant in TAA treated animals besides decreasing the TAA toxic effects on liver enzymes, liver and

Muusikamaailm : Hooaja algus "La Scalas". Verdi mälestusaastast mujalgi. Uusooper Ateenasse olümpia-aastaks. Soome ooperi "hullu aasta" lõpp / Priit Kuusk

Index Scriptorium Estoniae

Kuusk, Priit, 1938-

2000-01-01

Milano La Scala hooaja avaetendustest. G. Verdi ooperite lavastustest New Yorgi, Barcelona, Viini ja Helsingi ooperiteatrites. D. Mitropoulose nim. rahvusvahelisest heliloojate konkursist. K. Tikka uusooperi "Luther" maailmaesiettekandest 12. dets. Helsingi Koopakirikus

Eesti Filharmoonia Kammerkoori kontsert / Raul Pettai

Index Scriptorium Estoniae

Pettai, Raul, 1928-

2006-01-01

19. märtsil St. Ignatius Loyola kirikus New Yorgis, kaastegev inglise organist ja helilooja Christopher Bowers-Broadbent, dirigent Paul Hillier. Esitati Arvo Pärdi, Cyrillus Kreegi ja Sergei Rahmaninovi kooriloomingut

Kammermuusikat kahelt mandrilt / Toomas Velmet

Index Scriptorium Estoniae

Velmet, Toomas, 1942-

2010-01-01

12. mail New Yorgis Weill Recital Hallis toimunud keelpillikvarteti Pro Arte 12 kontserdist ja 22. mail sarjas "Meistrite akadeemia" Tallinnas Vene kultuurikeskuse väikese saalis toimunud Uus Tallinna Trio kontserdist

Paul Krugman: välisvaluuta külge klammerdumine pole jätkusuutlik / Paul Krugman

Index Scriptorium Estoniae

Krugman, Paul, 1953-

2009-01-01

Valik 2008. aasta Nobeli majanduspreemia laureaadi Paul Krugmani vastuseid New Yorgi välisajakirjanike pressikeskuse briifingul "Kas depressioonimajandus tuleb tagasi?" esitatud Slovakkia, Lõuna-Aafrika, Austraalia ja Austria ajakirjanike küsimustele

Structural and thermal properties of carboxylic acid functionalized polythiophenes

Directory of Open Access Journals (Sweden)

Ariane de França Mescoloto

2014-01-01

Full Text Available Polythiophenes functionalized with polar groups at the end of side-chain have emerged as an alternative method to obtain good compatibility between this class of conjugated polymers and electron acceptor compounds. The aim is to prevent phase segregation and to improve the efficiency of the polythiophene technological devices. However, homopolymers synthesized from thiophene rings with high polar groups at the end of the side-chain, such as hydroxyl and carboxylic acid groups, are poorly soluble in common volatile organic solvents. We report on a systematic preparation of copolymers of 3-hexylthiophene (HT and thiophene-3-acetic acid (TAA, using different feed ratios. The chemical structures of the copolymers were confirmed by FTIR and ¹H-NMR. The TAA content in these copolymers were 33, 38 and 54 mol %. HPSEC results did not show any remarkable correlation with TAA contents in the copolymers. In contrast, the thermal analyses showed a decrease in the thermal stability and an increase in rigidity of their backbones, for the copolymers with high amounts of TAA. The solubility and optical property of copolymers were also related to the TAA contents. Thus, the properties of these copolymers can be modulated by a simple control of feed ratio of TAA in the copolymerization.

Blood Transfusion During Total Ankle Arthroplasty Is Associated With Increased In-Hospital Complications and Costs.

Science.gov (United States)

Ewing, Michael A; Huntley, Samuel R; Baker, Dustin K; Smith, Kenneth S; Hudson, Parke W; McGwin, Gerald; Ponce, Brent A; Johnson, Michael D

2018-04-01

Total ankle arthroplasty (TAA) is an increasingly used, effective treatment for end-stage ankle arthritis. Although numerous studies have associated blood transfusion with complications following hip and knee arthroplasty, its effects following TAA are largely unknown. This study uses data from a large, nationally representative database to estimate the association between blood transfusion and inpatient complications and hospital costs following TAA. Using the Nationwide Inpatient Sample (NIS) database from 2004 to 2014, 25 412 patients who underwent TAA were identified, with 286 (1.1%) receiving a blood transfusion. Univariate analysis assessed patient and hospital factors associated with blood transfusion following TAA. Patients requiring blood transfusion were more likely to be female, African American, Medicare recipients, and treated in nonteaching hospitals. Average length of stay for patients following transfusion was 3.0 days longer, while average inpatient cost was increased by approximately 50%. Patients who received blood transfusion were significantly more likely to suffer from congestive heart failure, peripheral vascular disease, hypothyroidism, coagulation disorder, or anemia. Acute renal failure was significantly more common among patients receiving blood transfusion ( P < .001). Blood transfusions following TAA are infrequent and are associated with multiple medical comorbidities, increased complications, longer hospital stays, and increased overall cost. Level III: Retrospective, comparative study.

Evaluation of Postprandial Total Antioxidant Activity in Normal and Overweight Individuals

Directory of Open Access Journals (Sweden)

Fatma Arslan

2016-09-01

Full Text Available Aim: Postprandial changes acutely alter some mechanisms in body. There are many studies showing blood oxidative status changes after food intake, and supplementation. The aim of the present study was to evaluate the effects of a standardized meal on serum total antioxidant activity (TAA in normal weight and overweight individuals. Material and Method: Fourteen normal weight and twelve overweight individuals were given a standardized meal in the morning after an overnight fast. Serum TAA, glucose, total cholesterol, HDL cholesterol, LDL cholesterol, and triglyceride concentrations were measured at baseline, 3rd hour, and 6th hour after the meal in both groups.Results: In both normal and overweight groups, the difference between baseline and 3rd hour was significant for TAA. The TAA of the overweight group was also significantly lower than the TAA of the normal weight group at 3rd hour. However, there was no significant correlation between lipid parameters and TAA levels. Discussion: The present study shows that postprandial oxidative damage occurs more prominently in overweight individuals than in normal weight individuals. Postprandial changes acutely induce oxidative stress and impair the natural antioxidant defense mechanism. It should be noted that consuming foods with antioxidants in order to avoid various diseases and complications is useful, particularly in obese subjects.

Left atrium and pulmonary artery compression due to aortic aneurysm causing heart failure symptoms.

Science.gov (United States)

Jorge, Antonio José Lagoeiro; Martins, Wolney de Andrade; Moutinho, Victor M; Rezende, Juliano M; Alves, Patricia Y; Villacorta, Humberto; Silveira, Pedro F; Couto, Antonio A

2018-05-09

Patients with thoracic aortic aneurysm (TAA) are mostly asymptomatic and TAA is rarely related to heart failure (HF). We report the case of an 80-year-old female patient, with type A TAA without dissection, with right pulmonary artery and left atrium compression, who presented with HF, preserved ejection fraction and acute pulmonary edema. Copyright © 2018 Sociedade Portuguesa de Cardiologia. Publicado por Elsevier España, S.L.U. All rights reserved.

Kuidas kirjutada Oscarit väärt filmi / Andres Maimik

Index Scriptorium Estoniae

Maimik, Andres, 1970-

2003-01-01

Spike Jonze'i mängufilm "Kuidas kirjutada kassafilmi" ("Adaptation") : Ameerika Ühendriigid 2002 ja Martin Scorsese "New Yorgi jõugud" ("Gangs of New York") : Ameerika Ühendriigid - Saksamaa - Itaalia - Suurbritannia 2002

Maailma kõrgeim pilvelõhkuja sai eile nurgakivi

Index Scriptorium Estoniae

2004-01-01

4. VII pandi New Yorgis nurgakivi pilvelõhkuja ehitusele, mis peab asendama hävinud Maailma Kaubanduskeskust. 541 meetri kõrgune (1776 jalga) Vabadustorn peaks valmima 2009. aastaks. Projekti kavandas Daniel Libeskind

Kehanarratiivid / Gregory Slick ; tõlk. Mari Laaniste

Index Scriptorium Estoniae

Slick, Gregory

2003-01-01

Reio Aare, Toomas Kalve, Margot Kase, Herkki-Erich Merila fotonäitus "The Fragments of Silence: Meditative moments in contemporary Estonian photography" 10.-26. IV New Yorgi galeriis Annex. Kuraator Rael Artel

New York, rändurite linn / Kadri Kerge

Index Scriptorium Estoniae

Kerge, Kadri

2016-01-01

New York on linn, mille elanikkond ja ruum on pidevas muutumises. Ehitustegevuse tulemusena on uue ilme saanud kõik linnaosad. Aktuaalseim teema New Yorgi arhitektuuriringkondades ja ehituses on nn. ultrapilvelõhkujatega seonduv

Elavas teatris on iga näitleja kunstnik / Philip Brehse ; interv. Karol Kallas

Index Scriptorium Estoniae

Brehse, Philip

2007-01-01

Endine New Yorgi eksperimentaalse teatritrupi Living Theatre liige selle teatri põhimõtetest. Praegu on P. Brehse Pärnus külas Non Gratal, kelle partnerorganisatsiooni Open Space Performunion liige ta on

Muusikalisõda tõi esimesed langenud / Andres Laasik

Index Scriptorium Estoniae

Laasik, Andres, 1960-2016

2004-01-01

Vanalinnastuudio ja muusikalifirma Smithbridge Productions võib jääda ilma "Minu veetleva leedi" õigusest. New Yorgi agentuur väljastas ekslikult muusikali litsentsid nii Estoniale kui ka muusikalifirmale Tequila AD

Läti fond tunnustab maestro Neeme Järvit audiplomiga / Kärt Anvelt

Index Scriptorium Estoniae

Anvelt, Kärt, 1973-

2007-01-01

Tunnustusest läti heliloojate teoste ettekandmise ja salvestamise eest. 17. novembril 2007 antakse New Yorgis dirigendile üle Ülemaailmse Vabade Lätlaste Liidu Kultuurifondi audiplom. Dirigendi töödest

6 projekti impeeriumile / Ave Randviir

Index Scriptorium Estoniae

Randviir, Ave, 1981-

2002-01-01

Raoul Kurvitza näitusest "Impeerium. 6 projekti" Rakvere muuseumis. Eksponeeritud New Yorgi linnaruumi ja galeriidesse kavandatud projektide maketid. Time Square'ile kavandatud "Fundamentali" jaoks Ariel Lagle komponeerinud helitööst

Dollariafääris otsustav kohus / Jaanus Piirsalu

Index Scriptorium Estoniae

Piirsalu, Jaanus, 1973-

2001-01-01

Ühispank loodab täna New Yorgis algaval kohtuprotsessil saavutada soodsa otsuse 10 milj. dollari tagasisaamiseks USA pangalt Bankers Trust Company. 1994.a. S. Kallase juhitud Eesti Palgast alguse saanud dollariskandaal

Yoshiko Chuma Tallinnas

Index Scriptorium Estoniae

2001-01-01

17. aprillil Rotermanni Soolalaos tantsu ja muusikat ühendav õhtu, kus esinevad Taavi Kerikmäe, Priit Lehto ja New Yorgi koreograaf, lavastaja ja tantsija Yoshiko Chuma mono-performance'ga "Hurricane Holiday"

Automated evaluation of liver fibrosis in thioacetamide, carbon tetrachloride, and bile duct ligation rodent models using second-harmonic generation/two-photon excited fluorescence microscopy.

Science.gov (United States)

Liu, Feng; Chen, Long; Rao, Hui-Ying; Teng, Xiao; Ren, Ya-Yun; Lu, Yan-Qiang; Zhang, Wei; Wu, Nan; Liu, Fang-Fang; Wei, Lai

2017-01-01

Animal models provide a useful platform for developing and testing new drugs to treat liver fibrosis. Accordingly, we developed a novel automated system to evaluate liver fibrosis in rodent models. This system uses second-harmonic generation (SHG)/two-photon excited fluorescence (TPEF) microscopy to assess a total of four mouse and rat models, using chemical treatment with either thioacetamide (TAA) or carbon tetrachloride (CCl 4 ), and a surgical method, bile duct ligation (BDL). The results obtained by the new technique were compared with that using Ishak fibrosis scores and two currently used quantitative methods for determining liver fibrosis: the collagen proportionate area (CPA) and measurement of hydroxyproline (HYP) content. We show that 11 shared morphological parameters faithfully recapitulate Ishak fibrosis scores in the models, with high area under the receiver operating characteristic (ROC) curve (AUC) performance. The AUC values of 11 shared parameters were greater than that of the CPA (TAA: 0.758-0.922 vs 0.752-0.908; BDL: 0.874-0.989 vs 0.678-0.966) in the TAA mice and BDL rat models and similar to that of the CPA in the TAA rat and CCl 4 mouse models. Similarly, based on the trends in these parameters at different time points, 9, 10, 7, and 2 model-specific parameters were selected for the TAA rats, TAA mice, CCl 4 mice, and BDL rats, respectively. These parameters identified differences among the time points in the four models, with high AUC accuracy, and the corresponding AUC values of these parameters were greater compared with those of the CPA in the TAA rat and mouse models (rats: 0.769-0.894 vs 0.64-0.799; mice: 0.87-0.93 vs 0.739-0.836) and similar to those of the CPA in the CCl 4 mouse and BDL rat models. Similarly, the AUC values of 11 shared parameters and model-specific parameters were greater than those of HYP in the TAA rats, TAA mice, and CCl 4 mouse models and were similar to those of HYP in the BDL rat models. The automated

In Manhattan, the Roof of the World / Riho Lumi

Index Scriptorium Estoniae

Lumi, Riho

2002-01-01

Piret Loone töötab New Yorgis Manhattanil Sherman & Sterlingi õigusbüroos juristina; omab bakalaureusekraadi majandus- ja poliitikateadustes, magistrikraadi poliitikateadustes (Columbia ülikool) ja doktorikraadi äriõiguses (Harvardi ülikool)

Bashnja svobodõ

Index Scriptorium Estoniae

2004-01-01

New Yorgis pandi nurgakivi "Vabaduse tornile", mis rajatakse World Trade Center'i asemele. Maailma kõrgeim pilvelõhkuja plaanitakse valmis ehitada 2009. a., kogu uuendatud WTC kompleks 2015. a. Peaarhitekt on Daniel Libeskind

Privaatpankur: varastasin miljoneid, aga keegi ei märganud / Lynnley Browning, Diana B. Henriques

Index Scriptorium Estoniae

Browning, Lynnley

2009-01-01

New Yorgi privaatpankuri, UBSi ja JPMorgan Chase'i varakamate klientide haldurina töötanud Hernan E. Arbizu pettusest, mille käigus võttis ta ebaseaduslikult oma Lõuna-Ameerika klientidelt miljoneid dollareid

Sõjafilmid riisusid festivalil koore / M. P.

Index Scriptorium Estoniae

M. P.

2006-01-01

Tribeca filmifestival New Yorgis : parim mängufilm Argentiina lavastaja Tristan Baueri "Blessed by Fire" ; Deborah Scrantoni dokumentaal "War Tapes" sai ühe auhindadest. Festivalile pani viis aastat tagasi aluse Robert De Niro

Uudised : ERSO menu Rootsis. Õhtu Metropolitan Operas. NYYD Ensemble'i kontserdid / Madis Kolk

Index Scriptorium Estoniae

Kolk, Madis, 1953-

2001-01-01

ERSO kontserdireisist Rootsis. "Klassikaraadio" teeb 17. veebr. otseülekande New Yorgi Metropolitan Operast, kus tuleb ettekandele Rossini ooepr "Itaallanna Alzhiiris". NYYD Ensemble'i kontsertidest Pärnus ja Tallinnas kontserdisarjas "I Got Rhythm"

Massenet "Thaisi" näeb otseülekandes kinolinal / Toomas Kuter

Index Scriptorium Estoniae

Kuter, Toomas, 1965-

2008-01-01

Forum Cinemas toob oktoobrist maini Tallinnas Coca-Cola Plazas ja Tartus Ekraanis publikuni New Yorgi Metropolitan Opera etenduste HD-otseülekanded, 20. dets. kantakse üle Jules Massenet' ooper "Thais", peaosas Renee Fleming

Enron ja terrorirünnakud aitasid Eestit / Sulev Vedler

Index Scriptorium Estoniae

Vedler, Sulev, 1970-

2006-01-01

USA hiidfirma Enron krahh ja terrorirünnakud New Yorgi kaksiktornile ajasid nurja Eesti valitsuse kava erastada Narva elektrijaamad USA firmale NRG Energy. USA kompanii eelistamine ei tagaks julgeolekut. Diagramm: NRG tõuseb jalule

Suurlinnakorteri kellavärgiga apelsin / Adrian von Moos

Index Scriptorium Estoniae

Moos, Adrian von

2008-01-01

Ameerika sisekujundaja Giuseppe Pica New Yorgis asuvast korterist, kus omanik eksponeerib oma kunstikogu ja on sisustamisel püüdnud luua muljet avarusest. Kodune galerii on ka mugav elupaik. 8 värv. vaadet

Purustatud tornide asemele kerkivad uued hiigelhooned / Siim Trumm

Index Scriptorium Estoniae

Trumm, Siim

2006-01-01

Maailma Kaubanduskeskuse kaksiktornide asemele New Yorgis ehitatakse neli pilvelõhkujat - Vabaduse torn (peaarhitekt David Childs, s. 1941), Torn Kaks (arhitekt Norman Foster), Torn Kolm (arhitekt Richard Rogers), Torn Neli (arhitekt Fumihiko Maki) ja memoriaalmuuseum

Muusikamaailm : Dresdeni festivali juubel. Penderecki esimene klaverikontsert. Karajani festival Baden-Badenis. Aurel Stroe 70 / Priit Kuusk

Index Scriptorium Estoniae

Kuusk, Priit, 1938-

2002-01-01

Dresdeni muusikafestival toimub 25. korda. Penderecki esimese klaverikontserdi maailmaesiettekanne sai teoks New Yorgis. Ameerikas on maikuus mitmel korral üles astunud Gidon Kremer. Karajani festivalist Baden-Badenis. Rumeenia helilooja Aurel Stroe sai 70.aastaseks

Pepeljajev ja Jalakas said New Yorgist kätte Bessie' tantsupreemia / Margit Tõnson

Index Scriptorium Estoniae

Tõnson, Margit, 1978-

2004-01-01

Von Krahli Teatri lavastus - S. Pepeljajevi, P. Jalaka "Luikede järv", sai New Yorgis Bessie Award'i, millega auhinnatakse aasta kuut parimat tantsuetendust. Auhinnagalal käis Priit Raud, Von Krahli Teatri produtsent

Kiirreageerimistoad. Manifest, mida viiakse ka ellu = Emergency Rooms. A Manifesto put into Action / Thierry Geoffroy, Colonel

Index Scriptorium Estoniae

Geoffroy, Thierry, 1961-

2006-01-01

Rindereportaaži meetod kunstis - töid luuakse kiirelt ja reaalajas nagu meedias, iga päev vahetuvatel näitustel kommenteeritakse sama päeva uudiseid. Kiirreageerimistoad New Yorgis, Kopenhaagenis. Kiirreageerimistoa formaat

Ilse Leetaru graafika Kadriorus / Anne Lõugas

Index Scriptorium Estoniae

Lõugas, Anne, 1951-

1999-01-01

Kastellaanimajas 1. juulist avatud New Yorgis elava kunstniku Ilse Leetaru graafika näitusel eksponeeritakse töid Eesti Kunstimuuseumi kogust ja uusi teoseid, mis jäävad kingituseks Tallinna ja Tartu kunstimuuseumile

Tuumateadlane : Saddam loob "räpaseid" pomme / Khidhir Hamza

Index Scriptorium Estoniae

Hamza, Khidhir

2002-01-01

Iraagi tuumaprogrammi endise juhi Khidhir Hamza hinnangul on Saddam Hussein suure tõenäolisusega töötamas tuumapommi kallal. Neeme Raua valikul tehtud väljavõte vestlusest New Yorgis grupi ajakirjanikega

Välismaa arhitektuuriuudised / Mihkel Karu

Index Scriptorium Estoniae

Karu, Mihkel, 1983-

2008-01-01

Kunstimuuseum New Yorgis. Mälestusmärk Madridi 2004. aasta pommiplahvatuses hukkunutele (FAM Arquitectos). Teaduskeskus Taanis Nordborgis (arhitekt Jürgen Mayer). Eramu Jaapanis (Datar Architects). Noortekeskus Melbourne'is (Phooey Architects). Koolimaja Šveitsis (IPAS)

Ars ornata / Kadri Mälk

Index Scriptorium Estoniae

Mälk, Kadri, 1958-

1998-01-01

V rahvusvaheline ehtekunsti konverents 'Ars ornata Europeana' juuni lõpus Stockholmis. New Yorgis elava kuraatori Charon Kranseni ja prantsuse ehtekunstniku Christophe Burger' juhitud vestlusringidest. 1997. a. Pariisis loodud International Craft Design Association'ist (ICDA).

Characterization of CD8+ T-Cell Responses in the Peripheral Blood and Skin Injection Sites of Melanoma Patients Treated with mRNA Electroporated Autologous Dendritic Cells (TriMixDC-MEL

Directory of Open Access Journals (Sweden)

Daphné Benteyn

2013-01-01

Full Text Available Treatment of melanoma patients with mRNA electroporated dendritic cells (TriMixDC-MEL stimulates T-cell responses against the presented tumor-associated antigens (TAAs. In the current clinical trials, melanoma patients with systemic metastases are treated, requiring priming and/or expansion of preexisting TAA-specific T cells that are able to migrate to both the skin and internal organs. We monitored the presence of TAA-specific CD8+ T cells infiltrating the skin at sites of intradermal TriMixDC-MEL injection (SKILs and within the circulation of melanoma patients treated in two clinical trials. In 10 out of fourteen (71% patients screened, CD8+ T cells recognizing any of the four TAA presented by TriMixDC-MEL cellular vaccine were found in both compartments. In total, 30 TAA-specific T-cell responses were detected among the SKILs and 29 among peripheral blood T cells, of which 24 in common. A detailed characterization of the antigen specificity of CD8+ T-cell populations in four patients indicates that the majority of the epitopes detected were only recognized by CD8+ T cells derived from either skin biopsies or peripheral blood, indicating that some compartmentalization occurs after TriMix-DC therapy. To conclude, functional TAA-specific CD8+ T cells distribute both to the skin and peripheral blood of patients after TriMixDC-MEL therapy.

Characterization of CD8+ T-cell responses in the peripheral blood and skin injection sites of melanoma patients treated with mRNA electroporated autologous dendritic cells (TriMixDC-MEL).

Science.gov (United States)

Benteyn, Daphné; Van Nuffel, An M T; Wilgenhof, Sofie; Corthals, Jurgen; Heirman, Carlo; Neyns, Bart; Thielemans, Kris; Bonehill, Aude

2013-01-01

Treatment of melanoma patients with mRNA electroporated dendritic cells (TriMixDC-MEL) stimulates T-cell responses against the presented tumor-associated antigens (TAAs). In the current clinical trials, melanoma patients with systemic metastases are treated, requiring priming and/or expansion of preexisting TAA-specific T cells that are able to migrate to both the skin and internal organs. We monitored the presence of TAA-specific CD8(+) T cells infiltrating the skin at sites of intradermal TriMixDC-MEL injection (SKILs) and within the circulation of melanoma patients treated in two clinical trials. In 10 out of fourteen (71%) patients screened, CD8(+) T cells recognizing any of the four TAA presented by TriMixDC-MEL cellular vaccine were found in both compartments. In total, 30 TAA-specific T-cell responses were detected among the SKILs and 29 among peripheral blood T cells, of which 24 in common. A detailed characterization of the antigen specificity of CD8(+) T-cell populations in four patients indicates that the majority of the epitopes detected were only recognized by CD8(+) T cells derived from either skin biopsies or peripheral blood, indicating that some compartmentalization occurs after TriMix-DC therapy. To conclude, functional TAA-specific CD8(+) T cells distribute both to the skin and peripheral blood of patients after TriMixDC-MEL therapy.

Trends in Joint Replacement Surgery in Patients with Rheumatoid Arthritis.

Science.gov (United States)

Young, Bradley L; Watson, Shawna L; Perez, Jorge L; McGwin, Gerald; Singh, Jasvinder A; Ponce, Brent A

2018-02-01

This study analyzed trends in large total joint arthroplasties (TJA) and in the proportion of these procedures performed on patients with rheumatoid arthritis (RA). The US Nationwide Inpatient Sample (2002-2012) was used to identify the incidences of total shoulder (TSA), elbow (TEA), knee (TKA), hip (THA), and ankle (TAA) arthroplasty and the proportion of these performed with coexisting RA. The prevalence of RA among patients with TJA increased 3.0%. The prevalence of RA among cases of TEA and TSA decreased by 50% (p < 0.0001) and 18% (p = 0.0016), respectively; a 38.0% decrease occurred in the prevalence of RA among TAA (p = 0.06); and nonsignificant increases were seen among THA and TKA. The average age difference between RA and non-RA patients undergoing TJA narrowed by 2 years (p < 0.0001). There was a greater reduction in the proportion of TSA, TEA, and TAA groups among women with RA than men with RA. In the TSA and TEA groups, there was a reduction in the proportion of whites with RA, but not blacks. The proportion of privately insured TSA and TAA patients with RA decreased, while patients with RA undergoing TSA, TEA, or TAA who were receiving Medicaid (government medical insurance) remained relatively stable over time. The prevalence of RA has decreased among TSA and TEA patients. A nonsignificant decline occurred among TAA patients. The average age of TJA patients with RA is beginning to mirror those without RA. Sex ratios for TSA, TEA, and TAA patients are following a similar pattern. These results may be evidence of the success of modern RA treatment strategies.

Extrahepatic angiogenesis hinders recovery of portal hypertension and collaterals in rats with cirrhosis resolution.

Science.gov (United States)

Hsu, Shao-Jung; Tsai, Ming-Hung; Chang, Ching-Chih; Hsieh, Yu-Hsin; Huang, Hui-Chun; Lee, Fa-Yauh; Chuang, Chiao-Ling; Hou, Ming-Chih; Lee, Shou-Dong

2018-03-30

Liver cirrhosis is characterized by portal hypertension. However, the alteration of portal hypertension-related derangements during cirrhosis resolution is not well known. The present study aimed to establish animal models with cirrhosis resolution and to investigate the relevant changes during this process. Male Sprague-Dawley rats were applied. In reverse thioacetamide (rTAA) model, rats were randomly allocated into four groups with control, thioacetamide (TAA) cirrhosis and rTAA groups that discontinued TAA for 4 or 8 weeks after cirrhosis induction. In reverse bile duct ligation (rBDL) model, rats received choledochoduodenal shunt surgery upon the establishment of cirrhosis and 4, 8, or 16 weeks were allowed after the surgery. At the end, portal hypertension-related parameters were evaluated. Cirrhosis resolution was observed in rTAA groups. Portal pressure (PP) decreased after cirrhosis resolution but remained higher than control group (control, TAA, rTAA4, rTAA8 (mmHg): 5.4 ± 0.3, 12.9 ± 0.3, 8.6 ± 0.4, 7.6 ± 0.6). Further survey found the increased splanchnic blood flow did not reduce during cirrhosis resolution. The extrahepatic pathological angiogenesis was not ameliorated (% of mesenteric window area: 1.2 ± 0.3, 7.3 ± 1.1, 8.3 ± 1.0, 11.3 ± 2.7). In collateral system, the shunting degree reduced while the vessels structure remained. The vascular contractility of all systems and nitric oxide (NO) production were normalized. In rBDL series, PP decreased in rBDL16 groups but the extrahepatic angiogenesis persisted. In conclusion, cirrhosis resolution attenuates but not completely normalizes portal hypertension because of persistently high splanchnic inflow and angiogenesis. In clinical setting, vascular complications such as varices could persist after cirrhosis resolution and further investigation to define the follow-up and treatment strategies is anticipated. © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical

Kirjavahetus Kaarel Robert Pustaga / Karl Ast Rumor

Index Scriptorium Estoniae

Rumor, Karl, pseud., 1886-1971

2009-01-01

Kirjavahetus Rio de Janeiros elava Karl Ast Rumori ja New Yorgis elava Kaarel Robert Pusta vahel Eesti kongressi kokkukutsumise vajalikkuse, väliseesti ühingute ja nõukogude, ajakirjanduse ning üldise poliitilise olukorra teemadel

Eesti Kultuurifond Ühendriiges / Anne Valmas

Index Scriptorium Estoniae

Valmas, Anne, 1941-2017

2007-01-01

14. dets. 1957 toimus New Yorgi Eesti Majas Eesti Kultuurifondi Ühendriiges (The Foundation for Estonian Arts and Letters,) asutamiskoosolek. Kultuurifond loodi kunstide, rahvusteaduste, kirjanduse ja eesti keele edendamiseks ning on tegutsenud ligi pool sajandit

Wolfgang Staehle "The Thing" / Wolfgang Staehle ; interv. Tilman Baumgärtel

Index Scriptorium Estoniae

Staehle, Wolfgang

2006-01-01

1997. a. Berliinis tehtud intervjuu Stuttgardis 1950. a. sündinud ja New Yorgis elava kunstniku Wolfgang Staehle'ga, kes tööks elektroonilise kunsti kirjakastiga "The Thing" loobus videokunstniku karjäärist

Suri fetishismi isa

Index Scriptorium Estoniae

1999-01-01

New Yorgis suri kunstnik ja koomiksite joonistaja, pärastsõja-aegse Ameerika bondage-erootika illustraator Eric Stanton. Paar aastat tagasi avaldas Saksa kirjastus Taschen Stantoni elust ja loomingust raamatu, mille toimetas erootikafotograaf Eric Kroll

Von Krahli Teater toob Eestisse erakordse auhinna / Tiit Tuumalu

Index Scriptorium Estoniae

Tuumalu, Tiit, 1971-

2004-01-01

Bessie-auhinna puhul, millega New Yorgis pärjati Von Krahli Teatri lavastust "Luikede järv." Mõjukuselt on seda võrreldud Broadway teatriauhinna Tonyga. Lisatud lühiandmed P. Jalaka ja S. Pepeljajevi kohta

Uudised : Ansambel Blind sõlmis lepingu USA plaadikompaniiga. Värttinä esineb Euroopa päeval. Jethro Tull septembris Tallinnas

Index Scriptorium Estoniae

2001-01-01

Ans. Blind esines New Yorgi klubides ja sõlmis lepingu plaadikompaniiga LunaSea Records. 9. mail toimuval vabaõhukontserdil välisministeeriumi katusel esineb ans. Värttinä. Ans. Jethro Tull esineb 27. sept. Tallinnas

Kehakunsti valu ning võlu : kolm Manifesta performance'it / Harry Liivrand

Index Scriptorium Estoniae

Liivrand, Harry, 1961-

1998-01-01

Performance'id : New Yorgis elava poola kunstniku Piotr Uklanski 'Üleni põlemine', belgia kunstniku Honoré d'O 'Käsikiri varahoidjale', serblase Tanja Ostojici performance. Luksemburgi kunstniku Bert Theisi reis 'Dialektiline hüpe'

Nobel euro isale / Peter Lõhmus

Index Scriptorium Estoniae

Lõhmus, Peter

1999-01-01

Eesti Panga asepresident Peter Lõhmus tutvustab oma õpetajat, New Yorgi Columbia Ülikooli professorit Robert Mundelli, kes sai tänavase Nobeli majanduspreemia. Eeskätt on Mundell tuntud kui nn. optimaalse valuutapiirkonna teooria rajaja

Sigrid Viir võitis PULSE Kaasaegse Kunsti messi auhinna / Karin Laansoo ; fotod: Sigrid Viir

Index Scriptorium Estoniae

Laansoo, Karin, 1976-

2012-01-01

Laupäeval, 5. mail kuulutas PULSE Kaasaegse Kunsti messi preemiazhürii New Yorgis välja tänavuse messi peapreemia võitja - Eesti fotograafi Sigrid Viiru, keda esindas messil Temnikova & Kasela Galerii

Transfusion-associated anaphylaxis during anaesthesia and surgery

DEFF Research Database (Denmark)

Lindsted, G; Larsen, R; Krøigaard, M

2014-01-01

in Denmark. Our aims were to identify possible cases of TAA, to characterize their symptoms and tryptase levels and to investigate the reporting of TAA to the haemovigilance systems. MATERIAL AND METHODS: We reviewed 245 patients with suspected allergic reactions during anaesthesia and surgery, investigated...... and results of laboratory and clinical investigations were collected. TAA cases were identified according to the recommendations of the International Society of Blood Transfusion (ISBT). RESULTS: Ten possible TAA cases (30% of all transfused patients) were identified, all DAAC negative. The frequency...... at the Danish Anaesthesia Allergy Centre (DAAC). Based on the outcome of this investigation, the patients were classified as DAAC positive (confirmed hypersensitivity to identified agent, n = 112), or DAAC negative (no confirmed hypersensitivity, n = 133). Data on case history, details of blood transfusion...

Effect of Antimicrobial Peptide KSL-W on Human Gingival Tissue and C. albicans Growth, Transition and Secreted Aspartyl Proteinase (SAPS) 2, 4, 5 and 6 Expressions

Science.gov (United States)

2016-07-01

biofilm formation, and* Correspondence: mahmoud.rouabhia@fmd.ulaval.ca 1Oral Ecology Research Group, Faculty of Dentistry, Laval University, 2420, rue de la...details 1Oral Ecology Research Group, Faculty of Dentistry, Laval University, 2420, rue de la Terrasse, Quebec G1V 0A6, QC, Canada. 2Department of...States Army or Department of Defense. Conflict of Interest None declared Ethical approval Not required. Page 20 of 34 1 2 3 4 5 6 7 8 9 10 11

Aasta moekunstnik on Oscar de la Renta

Index Scriptorium Estoniae

2000-01-01

New Yorgis American Fashion Awards tseremoonial jagati auhindu: aasta parim naisterõivaste kujundaja Oscar de La Renta, parim meesteriiete looja Helmut Lang, elutöö preemia itaalia moekunstnik Valentinole, rahvusvahelise moekunsti auhind Jean Paul Gaultier'ile

Lumelinnad Kemis ja Rovaniemis / Rael Artel

Index Scriptorium Estoniae

Artel, Rael, 1980-

2004-01-01

Veebruari algul avati Soomes Rovaniemis ja Kemis lume- ja jääskulptuuri park "The Snow Show". Kuraator New Yorgi galerist Lance Fung. Osalenud kunstnikud ja arhitektid (Zaha Hadid, Juhani Pallasmaa, Anish Kapoor, Tadao Ando jt.)

Rüütel handed over the Order of the Gross of Terra Mariana to George H. W. Bush

Index Scriptorium Estoniae

2005-01-01

President Arnold Rüütel andis New Yorgis USA endisele presidendile Georg Herbert Walker Bushile Eesti iseseisvuspüüdluste toetamise eest Maarjamaa Risti I klassi ordeni. Töövisiit New Yorki 13.-17.09.2005

Chemical composition, bioactive compounds, and volatiles of six table grape varieties (Vitis vinifera L.).

Science.gov (United States)

Aubert, Christophe; Chalot, Guillaume

2018-02-01

Six table grape cultivars (Centennial Seedless, Chasselas, Italia, Italia Rubi, Alphonse Lavallée, and Muscat de Hambourg) were analyzed for their levels of soluble solids, titratable acidity, sugars, organic acids, vitamin C and E, carotenoids, polyphenolics and volatile compounds during two successive years. Descriptive sensory analyses of the six table grape varieties were also performed. Mainly due to anthocyanins, black cultivars had the highest total phenolic contents. Alphonse Lavallée had also both the highest levels of trans-resveratrol and piceid, and Muscat de Hambourg the highest levels of α-tocopherol, β-carotene and monoterpenols, well-known key aroma compounds in Muscat varieties having also interesting pharmacological properties. This study shows that the two traditional black French cultivars, Muscat de Hambourg and Alphonse Lavallée, are particularly rich in bioactive compounds and have a great potential for human health. Finally, Muscat de Hambourg was significantly rated sweeter, juicier and more aromatic than the others cultivars. Copyright © 2017 Elsevier Ltd. All rights reserved.

New Yorgi linnapea kaitseb Sopranosid / Triin Tael

Index Scriptorium Estoniae

Tael, Triin

2002-01-01

Linnapea Michael Bloomberg loobus osalemisest ameerika itaallaste paraadil, kuna tal ei lubatud kaasa võtta 2 maffiaseriaalis "Sopranod" mängivat näitlejat, sest korraldajate arvates seriaal halvustab itaallasi

Võimsate isiksuste paraad New Yorgis / Tanel Veenre

Index Scriptorium Estoniae

Veenre, Tanel, 1977-

2010-01-01

Marina Abramobići (Serbia) näitus "The Artist is Present" ja William Kentridge'i (Lõuna-Aafrika) söejoonistuste ja animatsioonide näitus "Five themes" MoMa-s (Museum of Modern Art). Tim Burtoni (USA) fotolavastuste, joonistuste ja installatsioonide näitus ning Agnolo Bronzino (1503-1572, Itaalia) joonistuste väljapanek Metropolitan Museumis

Täpne arhitektuur : ACADIA aastakonverents Cooper Unioni arhitektuurikoolis / Veronika Valk

Index Scriptorium Estoniae

Valk, Veronika, 1976-

2010-01-01

Septembris 2010 toimunud ACADIA aastakonverentsist New Yorgis. Konverents, töötoad ja näitus pakkusid parameetrilise projekteerimise spetsialistidele üle maailma lava, kus arhitektuuri uusi suundi arutada ja oma praktika üle mõtteid vahetada

Kai Kaljo tunnustatus jätkub

Index Scriptorium Estoniae

2000-01-01

Kai Kaljo esinemisest kuraator Hans Knolli näitusel "Communication...", New Yorgis Branka Stipancici kureeritud näitusel "Chinese whispers", Lõuna-Koreas Tom van Vliet kureeritud VI Pusani rahvusvahelisel kaasaegse kunsti festivalil, "World Wide Video" festivalil Amsterdamis

"Cremaster' tsükkel" : Matthew Barney avastusretk kunsti ja filmikunsti vahealal / Miriam Dagan ; tõlk. Epp Aareleid

Index Scriptorium Estoniae

Dagan, Miriam

2007-01-01

Ameerika kunstniku ja režissööri kunstnikufilmidest "Cremaster' tsükkel" (1994-2002). Viie tsükli põhisündmusest. Viienda filmi rekvisiitor oli Meeli Salumäe, Kostabi Maailma assistent New Yorgis

Novosti modõ / Jevgenija Fedorovskaja

Index Scriptorium Estoniae

Fedorovskaja, Jevgenija

2001-01-01

Kõrgmoenädalast Londonis - muudatusi seoses terroriaktiga New Yorgis. Jasper Conrani, Oscar de la Renta, Markus Lüpferi, John Rocha, Londoni kunstnike-dueti Blaak (pärit Lõuna-Aafrikast) kollektsioonidest ja poola kunstniku Arkadiuse art-objektide esitlusest

Potteru sdelali predlozhenije

Index Scriptorium Estoniae

2004-01-01

J.K. Rowling'u Harry Potteri lugude kolmas film "Harry Potter ja Azkabani vang" ("Harry Potter and the Prisoner of Azkaban") pidulik maailma-esilinastus toimus 23. mail New-Yorgis. 14-aastane peaosatäitja Daniel Radcliffe esilinastusel

Kõlakoda - inimene õpib kuulama kosmilist kõlakoda / Tiit Kändler

Index Scriptorium Estoniae

Kändler, Tiit, 1948-

2006-01-01

Universumi kõlakojast. Pilvelõhkujate võimalikust muutumisest kõlakodadeks. Näiteks toodud Manchesteris valmiv Beehtham Tower, Viini peahaigla, New Yorgi Cityspire'i torn Manhattanil. Kavakindlalt on uuritud Hollandis Hooke'is asuva näitusepaviljoni kõla

Rekordhind Man Ray eest

Index Scriptorium Estoniae

1998-01-01

Ameerika sürrealistliku fotograafi Man Ray 1926. a. Pariisis pildistatud foto 'Must ja valge, Pariis (positiiv ja negatiiv)', mis kujutab Ray armukese Kiki de Montparnasse'i portreed, maksis New Yorgi fotooksjonil 7, 3 miljonit Eesti krooni

Park asendas Manhattanil logistika / Rivo Sarapik

Index Scriptorium Estoniae

Sarapik, Rivo, 1981-

2010-01-01

New Yorgis Manhattani edelaosas rajati vanale raudteele, kümne meetri kõrgusele tänava kohale High Line Park. Arhitektid: Diller Scotidio + Renfro. New York Times valis pargi 2009. aasta arhitektuurialaste triumfide hulka New York Citys

Linn - sajandi suur armastus / Katrin Kivimaa

Index Scriptorium Estoniae

Kivimaa, Katrin, 1969-

2001-01-01

Tate Modern'is avatud näitusest "Sajandi linn : kunst ja kultuur modernses metropolis". Pariisi, Viini, Moskva, Lagose, Rio de Janeiro, Tokyo, New Yorgi, Londoni ja Bombay väljapanekutest. Järgneb 20. apr. 2002, lk. 8

Comparison of quality of life following total ankle arthroplasty and ankle arthrodesis: Retrospective study of 54 cases.

Science.gov (United States)

Dalat, F; Trouillet, F; Fessy, M H; Bourdin, M; Besse, J-L

2014-11-01

The benefit of ankle arthroplasty compared to arthrodesis continues to be debated, but the quality of life after these two interventions has rarely been assessed. We conducted a case-control study to compare quality of life and functional and athletic ability. Functional results, athletic ability, and quality of life after total ankle arthroplasty (TAA) are better than after ankle arthrodesis. Two continuous series of 59 TAAs and 46 arthrodeses (operated on between 1997 and 2009) were evaluated retrospectively using a questionnaire including the functional items of the AOFAS score, the Foot Function Index (FFI) score, the Foot Ankle Ability Measure (FAAM), and the SF-36. Eighty-three responses (79% of the overall series) were matched in two groups: 32 TAAs [age at the intervention, 51.4years (range, 21-63years); follow-up, 52.2months (range, 30-146months); age at revision, 55.8years (range, 26-67years); BMI, 27.7 (range, 21.7-36.7)] and 22 arthrodeses [age at intervention, 50.1years (range, 24-72years); follow-up 57.9months (range, 12-147months); age at revision 54.9 years (range, 31-75years); BMI, 26.8 (range, 17.6-37)] (NS on all items between the two groups). The pain results were better after TAA, but with no statistically significant difference: AOFAS pain, (/40) 28.1±8.2 vs. 24.5±9.6; FFI pain, 16.6±18.8 vs. 24.3±21.5. The overall FFI score (/100) was better (P=0.048) after TAA (16.2±16.5 vs. 24.8±18.2). The overall mean athletic level compared to the state prior to the injury was relatively low in both groups, but significantly (p=0.007) higher in the TAA group: FAAM sports score (/100), 49.5±24.4 vs. 29.8±26.2. The quality-of-life scores, SF-36 physical health, mental health, and general health were not significantly different after TAA and arthrodesis: mental health score, 63.1±14.7 vs. 57.8±21.5; physical health score, 61.3±17.8 vs. 53.7±23.9, overall score, 63.2±16.4 vs. 55.9±23.5. Very few publications describe activities and quality of

Ipomoea aquatica Extract Shows Protective Action Against Thioacetamide-Induced Hepatotoxicity

Directory of Open Access Journals (Sweden)

A. Hamid A. Hadi

2012-05-01

Full Text Available In the Indian system of traditional medicine (Ayurveda it is recommended to consume Ipomoea aquatica to mitigate disorders like jaundice. In this study, the protective effects of ethanol extract of I. aquatica against liver damage were evaluated in thioacetamide (TAA-induced chronic hepatotoxicity in rats. There was no sign of toxicity in the acute toxicity study, in which Sprague-Dawley (SD rats were orally fed with I. aquatica (250 and 500 mg/kg for two months along with administration of TAA (i.p injection 200 mg/kg three times a week for two months. The results showed that the treatment of I. aquatica significantly lowered the TAA-induced serum levels of hepatic enzyme markers (ALP, ALT, AST, protein, albumin, bilirubin and prothrombin time. The hepatic content of activities and expressions SOD and CAT that were reduced by TAA were brought back to control levels by the plant extract supplement. Meanwhile, the rise in MDA level in the TAA receiving groups also were significantly reduced by I. aquatica treatment. Histopathology of hepatic tissues by H&E and Masson trichrome stains displayed that I. aquatica has reduced the incidence of liver lesions, including hepatic cells cloudy swelling, infiltration, hepatic necrosis, and fibrous connective tissue proliferation induced by TAA in rats. Therefore, the results of this study show that the protective effect of I. aquatica in TAA-induced liver damage might be contributed to its modulation on detoxification enzymes and its antioxidant and free radical scavenger effects. Moreover, it confirms a scientific basis for the traditional use of I. aquatica for the treatment of liver disorders.

Anti-fibrotic effects of Cuscuta chinensis with in vitro hepatic stellate cells and a thioacetamide-induced experimental rat model.

Science.gov (United States)

Kim, Jin Seoub; Koppula, Sushruta; Yum, Mun Jeong; Shin, Gwang Mo; Chae, Yun Jin; Hong, Seok Min; Lee, Jae Dong; Song, MinDong

2017-12-01

Cuscuta chinensis Lam. (Convolvulaceae) has been used as a traditional herbal remedy for treating liver and kidney disorders. Anti-fibrotic effects of C. chinensis extract (CCE) in cellular and experimental animal models were investigated. HSC-T6 cell viability, cell cycle and apoptosis were analysed using MTT assay, flow cytometry and Annexin V-FITC/PI staining techniques. Thioacetamide (TAA)-induced fibrosis model was established using Sprague Dawley rats (n = 10). Control, TAA, CCE 10 (TAA with CCE 10 mg/kg), CCE 100 (TAA with CCE 100 mg/kg) and silymarin (TAA with silymarin 50 mg/kg). Fibrosis was induced by TAA (200 mg/kg, i.p.) twice per week for 13 weeks. CCE and silymarin were administered orally two times per week from the 7th to 13th week. Fibrotic related gene expression (α-SMA, Col1α1 and TGF-β1) was measured by RT-PCR. Serum biomarkers, glutathione (GSH) and hydroxyproline were estimated by spectrophotometer using commercial kits. CCE (0.05 and 0.1 mg/mL) and silymarin (0.05 mg/mL) treatment significantly (p < 0.01 and p < 0.001) induced apoptosis (11.56%, 17.52% for CCE; 16.50% for silymarin, respectively) in activated HSC-T6 cells, compared with control group (7.26%). Further, rat primary HSCs showed changes in morphology with CCE 0.1 mg/mL treatment. In in vivo studies, CCE (10 and 100 mg/kg) treatment ameliorated the TAA-induced altered levels of serum biomarkers, fibrotic related gene expression, GSH, hydroxyproline significantly (p < 0.05-0.001) and rescued the histopathological changes. CCE can be developed as a potential agent in the treatment of hepatofibrosis.

Endovascular stent-graft management of thoracic aortic diseases

International Nuclear Information System (INIS)

Dake, Michael D.

2001-01-01

The traditional standard therapy for descending thoracic aortic aneurysm (TAA) is open operative repair with graft replacement of the diseased aortic segment. Despite important advances in surgical techniques, anesthetic management, and post-operative care over the last 30 years, the mortality and morbidity of surgery remains considerable, especially in patients at high risk for thoracotomy because of coexisting severe cardiopulmonary abnormalities or other medical diseases. The advent of endovascular stent-graft technology provides an alternative to open surgery for selected patients with TAA. The initial experience suggests that stent-graft therapy potentially may reduce the operative risk, hospital stay and procedural expenses of TAA repair. These potential benefits are especially attractive for patients at high risk for open TAA repair. Current results of endovascular TAA therapy document operative mortalities of between 0 and 4%, aneurysm thrombosis in 90 and 100% of cases, and paraplegia as a complication in 0 and 1.6% of patients. The early success of stent-graft repair of TAA has fostered the application of these devices for the management of a wide variety of thoracic aortic pathologies, including acute and chronic dissection, intramural hematoma, penetrating ulcer, traumatic injuries, and other diseases. The results of prospective controlled trials that compare the outcomes of stent-graft therapy with those of surgical treatment in patients with specific types of aortic disease are anxiously awaited before recommendations regarding the general use of these new devices can be made with confidence

Aneurysm-Specific miR-221 and miR-146a Participates in Human Thoracic and Abdominal Aortic Aneurysms

Directory of Open Access Journals (Sweden)

Premakumari Venkatesh

2017-04-01

Full Text Available Altered microRNA expression is implicated in cardiovascular diseases. Our objective was to determine microRNA signatures in thoracic aortic aneurysms (TAAs and abdominal aortic aneurysms (AAAs compared with control non-aneurysmal aortic specimens. We evaluated the expression of fifteen selected microRNA in human TAA and AAA operative specimens compared to controls. We observed significant upregulation of miR-221 and downregulation of miR-1 and -133 in TAA specimens. In contrast, upregulation of miR-146a and downregulation of miR-145 and -331-3p were found only for AAA specimens. Upregulation of miR-126 and -486-5p and downregulation of miR-30c-2*, -155, and -204 were observed in specimens of TAAs and AAAs. The data reveal microRNA expression signatures unique to aneurysm location and common to both thoracic and abdominal pathologies. Thus, changes in miR-1, -29a, -133a, and -221 are involved in TAAs and miR-145, -146, and -331-3p impact AAAs. This work validates prior studies on microRNA expression in aneurysmal diseases.

A novel canine model of portal vein stenosis plus thioacetamide administration-induced cirrhotic portal hypertension with hypersplenism.

Science.gov (United States)

Lin, Dexin; Wu, Xianbin; Ji, Xiaoke; Zhang, Qiyu; Lin, YuanWei; Chen, WeiJian; Jin, Wangxun; Deng, Liming; Chen, Yunzhi; Chen, Bicheng; Li, Jianmin

2012-01-01

Current large animal models that could closely resemble the typical features of cirrhotic portal hypertension in human have not been well established. Thus, we aimed to develop and describe a reliable and reproducible canine cirrhosis model of portal hypertension. A total of 30 mongrel dogs were randomly divided into four groups: 1 (control; n = 5), 2 (portal vein stenosis [PVS]; n = 5], 3 (thioacetamide [TAA]; n = 5), and 4 (PVS plus TAA; n = 15). After 4-months modeling period, liver and spleen CT perfusion, abdominal CT scans, portal hemodynamics, gastroscopy, hepatic function, blood routine, the bone marrow, liver, and spleen histology were studied. The animals in group 2 (PVS) developed extrahepatic portosystemic collateral circulation, particularly esophageal varices, without hepatic cirrhosis and portal hypertension. Animals from group 3 (TAA) presented mild cirrhosis and portal hypertension without significant symptoms of esophageal varices and hypersplenism. In contrast, animals from group 4 (PVS + TAA) showed well-developed micronodular and macronodular cirrhosis, associated with significant portal hypertension and hypersplenism. The combination of PVS and TAA represents a novel, reliable, and reproducible canine cirrhosis model of portal hypertension, which is associated with the typical characteristics of portal hypertension, including hypersplenism.

Chaperonin GroE-facilitated refolding of disulfide-bonded and reduced Taka-amylase A from Aspergillus oryzae.

Science.gov (United States)

Kawata, Y; Hongo, K; Mizobata, T; Nagai, J

1998-12-01

The refolding characteristics of Taka-amylase A (TAA) from Aspergillus oryzae in the presence of the chaperonin GroE were studied in terms of activity and fluorescence. Disulfide-bonded (intact) TAA and non-disulfide-bonded (reduced) TAA were unfolded in guanidine hydrochloride and refolded by dilution into buffer containing GroE. The intermediates of both intact and reduced enzymes were trapped by GroEL in the absence of nucleotide. Upon addition of nucleotides such as ATP, ADP, CTP or UTP, the intermediates were released from GroEL and recovery of activity was detected. In both cases, the refolding yields in the presence of GroEL and ATP were higher than spontaneous recoveries. Fluorescence studies of intrinsic tryptophan and a hydrophobic probe, 8-anilinonaphthalene-1-sulfonate, suggested that the intermediates trapped by GroEL assumed conformations with different hydrophobic properties. The presence of protein disulfide isomerase or reduced and oxidized forms of glutathione in addition to GroE greatly enhanced the refolding reaction of reduced TAA. These findings suggest that GroE has an ability to recognize folding intermediates of TAA protein and facilitate refolding, regardless of the existence or absence of disulfide bonds in the protein.

Maffia upitab petuskeemidega aktsiaid üles / Neeme Raud

Index Scriptorium Estoniae

Raud, Neeme, 1969-

2003-01-01

Tutvustades filmi "Boiler Room" ja Gary Weissi raamatut "Born To Steal" näitab autor sidet 1990. aastate alguses New Yorgi börsile imbunud organiseeritud kuritegevuse ja kümnendi teisel poolel suurtes investeeringufirmades toimunud pettuste vahel

New York ja rotid kuuluvad kokku nagu Pariis ja armastajad / Neeme Raud

Index Scriptorium Estoniae

Raud, Neeme, 1969-

2007-01-01

Vt. ka Postimees : na russkom jazõke 16. märts, lk. 10. Sanitaarekspertide sõnul on New Yorgi rotiprobleemi peamiseks põhjuseks linna prügikoristamise viis. Vt. samas: Newyorklased ja linna rotid on üsna sarnased

New York kuulutas sõja liigsuurele õgimisele / Neeme Raud

Index Scriptorium Estoniae

Raud, Neeme, 1969-

2007-01-01

Juuli alguses jõustusid New Yorgis uued reeglid kiirsöögikohtadele, mis peavad nüüdsest menüü kõrvale kirjutama ka teabe, kui palju kaloreid burgerid, friikartulid ja kokteilid tegelikult sisaldavad. Lisa: Uued toitlustusreeglid

Uudised : Viis ameerika tipporkestrit Kölnis. Schuberti konkurss Grazis. "Kreeka passioon" Londonis. Riccardo Muti tuleb New Yorki? / Priit Kuusk

Index Scriptorium Estoniae

Kuusk, Priit, 1938-

2000-01-01

Kölni uue muusika triennaalist, sealsetest esinejatest. IV rahvusvahelisest konkursist "Franz Schubert und die Musik der Moderne". B. Martinu ooperi "Kreeka passioon" esietendusest Londoni Kuninglikus Ooperis. R. Mutist võib aastal 2002 saada New Yorgi Filharmoonia Orkestri peadirigent

Probleemid maailma kõrgeima hoone projektiga

Index Scriptorium Estoniae

2003-01-01

New Yorgi Maailma Kaubanduskeskuse asemele uue hoone rajamiseks korraldatud rahvusvahelise athitektuurikonkursi II vooru finaali jõudsid disainitandemi THINK (Rafael Vinoly, Frederic Schwartz) ja Daniel Libeskindi projektid. 25. II valis žürii välja D. Libeskindi variandi

Bagatellid : Maailm / Nele-Eva Steinfeld

Index Scriptorium Estoniae

Steinfeld, Nele-Eva

2009-01-01

Muusikasõnumeid maailmast: Cecilia Bartoli pälvis Leonie Sonningi auhinna. Lorin Maazel jätab hüvasti New Yorgi Filharmoonikutega. Leitud kaks uut Mozarti klaveriteost. Uudiseid konkursimaailmast. Rootsi Raadio P2 resideerivaks heliloojaks valiti Mirjam Tally

Uus video, uus Euroopa / Kiwa

Index Scriptorium Estoniae

Kiwa, pseud., 1975-

2006-01-01

New Yorgi kunstikeskuses The Kitchen avatud endiste idablokimaade videokunstnike tööde näitusest. Eestlastest eksponeeritud Kiwa, Ene-Liis Semperi, Killu Sukmiti, Mari Laanemetsa, Tiia Johannsoni ja Kai Kaljo tööd. Kuraator Hamza Walker

75 FR 41433 - Trade Adjustment Assistance for Farmers

Science.gov (United States)

2010-07-16

... DEPARTMENT OF AGRICULTURE Foreign Agricultural Service Trade Adjustment Assistance for Farmers... Economic Research Service and reviewed by the TAA for Farmers Review Committee, comprised of... TAA for Farmers' Program Should Contact: USDA, Farm Service Agency (at your local service center). FOR...

Taas joonistamisest / Merike Trubert

Index Scriptorium Estoniae

Trubert, Merike

2011-01-01

Tartu Kõrgema Kunstikooli joonistamise õppejõud Merike Trubert probleemidest kunstikõrgkoolides joonistamise õpetamisel, joonistamisõpetuse vajalikkusest üldhariduses, joonistamisest kui iseseisvast kunstiliigist, joonistamise populariseerimisest maailmas, pikemalt ürituste programmist "Big Draw" Suurbritannias

Eesti disain taas Pariisis

Index Scriptorium Estoniae

2007-01-01

Eesti Disainerite Liit esitleb septembris 2007 oma kollektsiooni Pariisi sisustusmessi Maison&Object disainisektsioonis NOW! Stendi kujundus on Anneli Lobjalt. Osalejatest nimetatud: Annike Laigo, Merike Rehepapp, Jaanus Orgusaar, Jan Graps, Ken Ruut, Jaakko Matsalu, Eva-Liisa Kriis, Liisa Kallam, Liisa Tomasberg, Tarmo Luisk, Monika Järg, Keret Altpere, Elna Kaasik, Tõnis Vellama ja Ilona Gurjanova

Eesti joonisfilm taas edukas

Index Scriptorium Estoniae

2003-01-01

Riia I rahvusvahelisel animafilmide festivalil võitis "Kontsert porgandipirukale" parima animafilmi auhinna. Grand prix'i sai inglase Ignacio Ferreresi film "How to Cope With a Death". Žüriisse kuulus ka Rein Raamat

Paavst Johannes Paulus II meenutades

Index Scriptorium Estoniae

2005-01-01

New Yorgi Eesti Pensionäride Klubi esinaise Laine Tigase külaskäigust Vatikani 21. oktoobril 1992, kingituseks paavstile võttis ta kaasa Marie Underi luulekogu "Child of God", mis nüüd asub Vatikani raamatukogus

Rüütliga kohtunud Ivanov lubas tänavu Eestisse tulla

Index Scriptorium Estoniae

2003-01-01

Ilmunud ka Postimees (2003/Sep/24) lk. 3. President Arnold Rüütliga New Yorgis kohtunud Venemaa välisminister Igor Ivanov kinnitas, et tal on kavas Eestisse visiidile tulla. Töövisiit New Yorki 20.-26.09.2003

Obnazhonka s molotka

Index Scriptorium Estoniae

2008-01-01

Christie'se oksjonil New Yorgis tuleb müügile saksa kollektsionääri Gert Elferingi kollektsioon kuulsuste aktifotodest. Kollektsioonis on 135 fotot maailmakuulsatelt fotograafidelt Helmut Newton, Richard Avedon, Man Ray, Diane Arbus, Horst P. Horst ja teised

"Väliseestlus - väljasuremisele määratud?" / Merike Pärtel

Index Scriptorium Estoniae

Pärtel, Merike

2007-01-01

kevadiste New Yorgi Eesti Kultuuripäevade (29. märts - 1. aprill) ajal toimuv foorum kutsub kõiki arutlema eestluse oleviku ja tuleviku üle. Kava ja alateemad, info: merikepartel@yahoo.com või telefon 646 750 6872

Eesti kunst Ühendriikidest tagasi

Index Scriptorium Estoniae

2001-01-01

31 I andsid korraldajad ülevaate 2000. a. USA-s New Yorgis, Washingtonis, Chicagos, Houstonis ja Los Angeleses eksponeeritud näitusest "Baltic Art Exhibition", kus Eestit esindasid 15 skulptorit ja maalikunstnikku. Näituse korraldamise idee autor Hamid Ladjevard.

Roosevelti monument vene kunstnikult / Maria-Kristiina Soomre

Index Scriptorium Estoniae

Soomre, Maria-Kristiina, 1978-

2001-01-01

Zurab Tsereteli uus projekt on Queensi ja Manhattani vahelisele Roosevelt Islandile rajatava kaasaegse vene kunsti muuseumi ette plaanitav Theodore Roosevelti mälestusmärk. New Yorgis ÜRO peakorteri ees asub Z. Tsereteli Püha Jüri skulptuur

Tree age, fruit size and storage conditions affect levels of ascorbic acid, total phenolic concentrations and total antioxidant activity of 'Kinnow' mandarin juice.

Science.gov (United States)

Khalid, Samina; Malik, Aman U; Khan, Ahmad S; Shahid, Muhammad; Shafique, Muhammad

2016-03-15

Bioactive compounds (ascorbic acid, total phenolics and total antioxidants) are important constituents of citrus fruit juice; however, information with regard to their concentrations and changes in relation to tree age and storage conditions is limited. 'Kinnow' (Citrus nobilis Lour × Citrus deliciosa Tenora) mandarin juice from fruit of three tree ages (6, 18 and 35 years old) and fruit sizes (large, medium and small) were examined for their bioactive compounds during 7 days under ambient storage conditions (20 ± 2 °C and 60-65% relative humidity (RH)) and during 60 days under cold storage (4 ± 1 °C and 75-80% RH) conditions. Under ambient conditions, a reduction in total phenolic concentrations (TPC) and in total antioxidant activity (TAA) was found for the juice from all tree ages and fruit sizes. Overall, fruit from 18-year-old trees had higher mean TPC (95.86 µg mL(-1) ) and TAA (93.68 mg L(-1) ), as compared to 6 and 35-year-old trees. Likewise, in cold storage, TAA decreased in all fruit size groups from 18 and 35-year-old trees. In all tree age and fruit size groups, TPC decreased initially during 15 days of cold storage and then increased gradually with increase in storage duration. Ascorbic acid concentrations showed an increasing trend in all fruit size groups from 35-year-old trees. Overall, during cold storage, fruit from 18-year-old trees maintained higher mean ascorbic acid (33.05 mg 100 mL(-1) ) concentrations, whereas fruit from 6-year-old trees had higher TAA (153.1 mg L(-1) ) and TPC (115.1 µg mL(-1) ). Large-sized fruit had higher ascorbic acid (32.08 mg 100 mL(-1) ) concentrations and TAA (157.5 mg L(-1) ). Fruit from 18-year-old trees maintained higher TPC and TAA under ambient storage conditions, whereas fruit from 6-year-old trees maintained higher TPC and TAA during cold storage. Small-sized fruit had higher TPC after ambient temperature storage, whereas large fruit size showed higher ascorbic acid concentrations and TAA after cold

75 FR 41432 - Trade Adjustment Assistance for Farmers

Science.gov (United States)

2010-07-16

... DEPARTMENT OF AGRICULTURE Foreign Agricultural Service Trade Adjustment Assistance for Farmers... Service and reviewed by the TAA for Farmers Review Committee, comprised of representatives from USDA's.... Producers Certified as Eligible for TAA for Farmers' Program Should Contact: USDA, Farm Service Agency (at...

Kurjategijaist kunstnikud / Maria-Kristiina Soomre

Index Scriptorium Estoniae

Soomre, Maria-Kristiina, 1978-

2000-01-01

Oktoobris arreteeris New Yorgi politsei SOHO galeriis oma näitust üles pannud kunstnikud Todd James'i (29 a.) ja Josh Lazcano (25 a.), kes viljelevad graffitimõjutustega kunsti. Põhjuseks oli graffiti - kunstnikke süüdistatakse omandi kahjustamises

Jungi salajane teos toodi seifist lagedale / Kaarel Kressa

Index Scriptorium Estoniae

Kressa, Kaarel, 1983-

2009-01-01

Carl Gustav Jungi Esimese maailmasõja järel kirjutatud teose "Liber Novus" käsikiri pannakse välja New Yorgi Rubini muuseumis. Samal päeval ilmub teos ka inglise ja saksa keeles raamatupoodidesse (kirjastaja W. W. Norton&Company)

Harry Potteri ABC

Index Scriptorium Estoniae

2002-01-01

Tutvustavat näitlejate ja nende rollide juurde J.K. Rowling'u Harry Potteri lugude teises filmis "Harry Potter ja saladuste kamber" ("Harry Potter and the Chamber of Secrets") : režissöör Chris Columbus. Filmi esilinastumisest New Yorgis

В Нью-Йорке поминали жертв 11 сентября / Неэме Рауд

Index Scriptorium Estoniae

Рауд, Неэме, 1969-

2011-01-01

USA president Barack Obama ja välisminister Hillary Clinton rõhutasid 11. septembri terrorirünnaku aastapäeval, et Ameerika Ühendriigid ei tohi oma valvsust kaotada, sest terrorioht ei kao kuhugi. New Yorgis toimunud mälestustseremooniast

Obama: me keeldume elamast hirmus / Neeme Raud

Index Scriptorium Estoniae

Raud, Neeme, 1969-

2011-01-01

USA president Barack Obama ja välisminister Hillary Clinton rõhutasid 11. septembri terrorirünnaku aastapäeval, et Ameerika Ühendriigid ei tohi oma valvsust kaotada, sest terrorioht ei kao kuhugi. New Yorgis toimunud mälestustseremooniast

Linnade klubi / Michael Bloomberg

Index Scriptorium Estoniae

Bloomberg, Michael

2007-01-01

New Yorgi linnapea räägib vajadusest suurendada linnadevahelist koostööd. Sündimas on uus globaalne urbanistlik kogukond, milles linnad teevad üksteisega koostööd ühesuguste probleemide kallal, võisteldes samal ajal omavahel globaalsel turul

John Cale avaldas memuaarid

Index Scriptorium Estoniae

1999-01-01

Rockbändi "The Velvet Underground" asutajaliige John Cale avaldas oma autobiograafia "What's Welsh for Zen?". Koos biograafiakirjanik Victor Bockrisiga kirjutatud teos räägib 60ndate lõpu kultuurielust New Yorgis, koostööst Andy Warholiga jm.

Kombates elu ja kunsti piire / Jaak Kangilaski

Index Scriptorium Estoniae

Kangilaski, Jaak, 1939-

2011-01-01

Serbia kunstniku Marina Abramovići loomingu näitus New Yorgi Moodsa Kunsti Muuseumis MoMa 2010. aasta kevadel. Näitus "Art Must Be Beautiful. Marina Abramovići valitud teosed" Tartu Kunstimuuseumis 13. novembrini 2011. Performance-kunsti ajaloost

Kolmas Potteri-film avab end maailmale / Neeme Korv

Index Scriptorium Estoniae

Korv, Neeme, 1974-

2004-01-01

J.K. Rowling'u Harry Potteri lugude kolmas film "Harry Potter ja Azkabani vang" ("Harry Potter and the Prisoner of Azkaban") pidulik maailma-esilinastus toimus 23. mail New-Yorgis. Filmi režissöör on mehhiklane Alfonso Cuaron

Looking for security in cyberspace / Ella Karapetyan

Index Scriptorium Estoniae

Karapetyan, Ella

2010-01-01

Küberkuritegevuse arengust. 16. juunil 2010 avatud NATO Küberkaitsekeskuse konverentsist ja president Toomas Hendrik Ilvese kõnest konverentsi avamisel. 21. juulil teatas välisministeerium, et kuritegevust uuriv ekspertide rühm lõpetas oma töö New Yorgis

Tartu 2003 : Teater

Index Scriptorium Estoniae

2003-01-01

Tartu teatrielu sündmustest 2003 - M. Savitski osalemine New Yorgi balletikonkursil, T. Lensmendi lavastus "Kihnu Jõnn", M. Undi lavastus "Aida", P. Pedajase lavastus "Nipernaadi", M.Kasterpalu juhitud Tartu Teatrilabori korraldatud teatrifestival "Draama 2003", A. Mäe asumine Vanemuise teatrijuhi kohale

Lauluarmastaja, võitleja, unustamatu sõber Oscar Uusima saadeti igaviku teedele / Airi Vaga

Index Scriptorium Estoniae

Vaga, Airi, 1940-

2007-01-01

järelehüüe EELK Bergen County koguduse nõukogu liikmele, koguduse revisjoni komisjoni esimehele, New Yorgi Eesti Meeskoori lauljale ja juhatuse esimehele, korporatsiooni Estica USA koondise esimehele ja abiesimehele Oscar Uusimale 24. 09. 1917 - 17. 07. 2007

Grjaznoje proshloje kuklõ Barbi / Igor Silenko

Index Scriptorium Estoniae

Silenko, Igor

2002-01-01

Nukk Barbie saamislugu - meestele mõeldud seksapiilne saksa nukuke Lilly (autoriks disainer Max Weissbrodt) sai ameerika disaineri Ruth Handleri käe all uue näo ja nime ning debüteeris 1959. a. New Yorgi mänguasjade laadal

Whitney biennaal tulekul / Maria-Kristiina Soomre

Index Scriptorium Estoniae

Soomre, Maria-Kristiina, 1978-

2001-01-01

7. III-26. V 2002 New Yorgi Whitney Ameerika Kunsti Muuseumis toimuvast 71. Whitney biennaalist. Osalejatest. Esindatud on kõik kunstiliigid maalikunstist netikunstini, olulist rõhku on pandud helikunstile, performanceile, videole ja arhitektuurile. Kuraator Lawrence R. Rinder. Väljaantavast Bucksbaumi auhinnast.

Abnormal secretion or extracellular matrix incorporation of fibrillin by dermal fibroblasts from patients with thoracic aortic aneurysms

Energy Technology Data Exchange (ETDEWEB)

Milewicz, D.; Cao, S.; Cosselli, J. [Univ. of Texas Medical School, Houston, TX (United States)

1994-09-01

Abnormal synthesis, secretion, and extracellular matrix incorporation of fibrillin is observed in the majority of fibroblast cell strains obtained from individuals with the Marfan syndrome (>85%). These fibrillin protein abnormalities are due to mutations in the FBN1 gene. We have screened fibroblast cell strains from patients with thoracic aortic aneurysms (TAA) without skeletal or ocular features of the Marfan syndrome for defects in fibrillin synthesis or processing. Dermal fibroblasts obtained from biopsies were pulse labeled with [{sup 35}S]cysteine for 30 minutes and then chased for 0, 4, and 20 hours. The media, cell lysate and extracellular matrix were harvested separately, then analyzed by SDS-PAGE. We selected fibroblasts from 17 TAA patients to study based on the development of a TAA at a young age or a family history of TAAs. Cells from 3 patients synthesized and secreted fibrillin normally, but did not incorporate the fibrillin in the extracellular matrix. None of the cell strains were found to have diminished synthesis of fibrillin when compared with control cells. We were unable to detect abnormalities in the synthesis, secretion, or matrix incorporation of fibrillin by cells from 9 of the 17 patients. These results indicate that fibrillin protein defects are found in a significant number of patients with TAAs who are young or have a family history of TAAs. Analysis of the FBN1 gene for mutations in these patients with fibrillin protein defects will determine if the observed protein abnormalities are the result of FBN1 gene mutations.

Endovascular Treatment of Late Thoracic Aortic Aneurysms after Surgical Repair of Congenital Aortic Coarctation in Childhood

Science.gov (United States)

Juszkat, Robert; Perek, Bartlomiej; Zabicki, Bartosz; Trojnarska, Olga; Jemielity, Marek; Staniszewski, Ryszard; Smoczyk, Wiesław; Pukacki, Fryderyk

2013-01-01

Background In some patients, local surgery-related complications are diagnosed many years after surgery for aortic coarctation. The purposes of this study were: (1) to systematically evaluate asymptomatic adults after Dacron patch repair in childhood, (2) to estimate the formation rate of secondary thoracic aortic aneurysms (TAAs) and (3) to assess outcomes after intravascular treatment for TAAs. Methods This study involved 37 asymptomatic patients (26 female and 11 male) who underwent surgical repair of aortic coarctation in the childhood. After they had reached adolescence, patients with secondary TAAs were referred to endovascular repair. Results Follow-up studies revealed TAA in seven cases (19%) (including six with the gothic type of the aortic arch) and mild recoarctation in other six (16%). Six of the TAA patients were treated with stentgrafts, but one refused to undergo an endovascular procedure. In three cases, stengrafts covered the left subclavian artery (LSA), in another the graft was implanted distally to the LSA. In two individuals, elective hybrid procedures were performed with surgical bypass to the supraaortic arteries followed by stengraft implantation. All subjects survived the secondary procedures. One patient developed type Ia endoleak after stentgraft implantation that was eventually treated with a debranching procedure. Conclusions The long-term course of clinically asymptomatic patients after coarctation patch repair is not uncommonly complicated by formation of TAAs (particularly in individuals with the gothic pattern of the aortic arch) that can be treated effectively with stentgrafts. However, in some patients hybrid procedures may be necessary. PMID:24386233

New insights into nucleation. Pressure trace measurements and the first small angle X-ray scattering experiments in a supersonic laval nozzle

International Nuclear Information System (INIS)

Ghosh, D.

2007-01-01

Homogeneous nucleation rates of the n-alcohols and the n-alkanes have been determined by combining information from two sets of supersonic Laval nozzle expansion experiments under identical conditions. The nucleation rates J=N/Δt Jmax for the n-alcohols are in the range of 1.10 17 -3 s -1 17 for the temperatures 207≤T/K≤249, the nucleation rates for the n-alkanes lie in the range of 5.10 15 -3 s -1 18 for the temperatures 143 ≤T/K≤215. For the first time it is shown that the nucleation rate is not only a function of the supersaturation and temperature but clearly also sensitive to the expansion rate during supersonic nozzle expansion. A good agreement between the experimental results and those available in literature is found by applying Hale's scaling formalism [Hale, B., Phys. Rev. A 33, 4256 (1986); Hale, B., Metall. Trans. A 23, 1863 (1992)]. The scaling parameters from this work are also in good agreement with those shown by Rusyniak et al. [Rusyniak, M., M. S. El-Shall, J. Phys. Chem. B 105, 11873 (2001)] and Brus et al. [Brus, D., V. Zdimal F. Stratmann, J. Chem Phys. 124, 164306 (2006)]. In the first experiment static pressure measurements were conducted for the n-alkanes to determine the condensible partial pressure, temperature, supersaturation, characteristic time, and the expansion rate corresponding to the maximum nucleation rate. Characteristic times in the range of 13≤Δt Jmax /μs≤34 were found. In the second set of experiments, the first flow rate resolved Small Angle X-ray Scattering experiments are conducted to determine the particle number density for both substance classes. Particle number densities in the range of 1.10 12 -3 12 and 1.10 11 -3 12 for the n-alcohols and n-alkanes are found, respectively. Additionally, by analyzing the radially averaged scattering spectrum, information on the mean radius and the width of the size distribution of the aerosols is obtained. Mean radii for the n-alcohols in the range of 4< left angle r

75 FR 48931 - Trade Adjustment Assistance for Farmers

Science.gov (United States)

2010-08-12

... DEPARTMENT OF AGRICULTURE Foreign Agricultural Service Trade Adjustment Assistance for Farmers... assistance and cash benefits. FOR FURTHER INFORMATION CONTACT: Trade Adjustment Assistance for Farmers....usda.gov ; or visit the TAA for Farmers' Web site: www.fas.usda.gov/itp/taa . Dated: July 30, 2010...

75 FR 48642 - Trade Adjustment Assistance for Farmers

Science.gov (United States)

2010-08-11

... DEPARTMENT OF AGRICULTURE Foreign Agricultural Service Trade Adjustment Assistance for Farmers... benefits. FOR FURTHER INFORMATION CONTACT: Trade Adjustment Assistance for Farmers Program Staff, FAS, USDA... the TAA for Farmers' Web site: http://www.fas.usda.gov/itp/taa . Dated: July 30, 2010. John D. Brewer...

75 FR 49458 - Trade Adjustment Assistance for Farmers

Science.gov (United States)

2010-08-13

... DEPARTMENT OF AGRICULTURE Foreign Agricultural Service Trade Adjustment Assistance for Farmers... and cash benefits. FOR FURTHER INFORMATION CONTACT: Trade Adjustment Assistance for Farmers Program....gov ; or visit the TAA for Farmers' Web site: http://www.fas.usda.gov/itp/taa . Dated: August 3, 2010...

75 FR 11513 - Trade Adjustment Assistance for Farmers

Science.gov (United States)

2010-03-11

... DEPARTMENT OF AGRICULTURE Foreign Agricultural Service Trade Adjustment Assistance for Farmers... Service (FAS), will begin accepting Trade Adjustment Assistance (TAA) for Farmers petitions for fiscal... received by the TAA for Farmers Staff by close of business April 14, 2010. The petition must be sent in...

Shared Genetic Risk Factors of Intracranial, Abdominal, and Thoracic Aneurysms

NARCIS (Netherlands)

van 't Hof, Femke N G; Ruigrok, Ynte M; Lee, Cue Hyunkyu; Ripke, Stephan; Anderson, Graig; de Andrade, Mariza; Baas, Annette F; Blankensteijn, Jan D; Böttinger, Erwin P; Bown, Matthew J; Broderick, Joseph; Bijlenga, Philippe; Carrell, David S; Crawford, Dana C; Crosslin, David R; Ebeling, Christian; Eriksson, Johan G; Fornage, Myriam; Foroud, Tatiana; von Und Zu Fraunberg, Mikael; Friedrich, Christoph M; Gaál, Emília I; Gottesman, Omri; Guo, Dong-Chuan; Harrison, Seamus C; Hernesniemi, Juha; Hofman, Albert; Inoue, Ituro; Jääskeläinen, Juha E; Jones, Gregory T; Kiemeney, Lambertus A L M; Kivisaari, Riku; Ko, Nerissa; Koskinen, Seppo; Kubo, Michiaki; Kullo, Iftikhar J; Kuivaniemi, Helena; Kurki, Mitja I; Laakso, Aki; Lai, Dongbing; Leal, Suzanne M; Lehto, Hanna; LeMaire, Scott A; Low, Siew-Kee; Malinowski, Jennifer; McCarty, Catherine A; Milewicz, Dianna M; Mosley, Thomas H; Nakamura, Yusuke; Nakaoka, Hirofumi; Niemelä, Mika; Pacheco, Jennifer; Peissig, Peggy L; Pera, Joanna; Rasmussen-Torvik, Laura; Ritchie, Marylyn D; Rivadeneira, Fernando; van Rij, Andre M; Santos-Cortez, Regie Lyn P; Saratzis, Athanasios; Slowik, Agnieszka; Takahashi, Atsushi; Tromp, Gerard; Uitterlinden, André G; Verma, Shefali S; Vermeulen, Sita H; Wang, Gao T; Han, Buhm; Rinkel, Gabriël J E; de Bakker, Paul I W

2016-01-01

BACKGROUND: Intracranial aneurysms (IAs), abdominal aortic aneurysms (AAAs), and thoracic aortic aneurysms (TAAs) all have a familial predisposition. Given that aneurysm types are known to co-occur, we hypothesized that there may be shared genetic risk factors for IAs, AAAs, and TAAs. METHODS AND

Shared genetic risk factors of intracranial, abdominal, and thoracic aneurysms

NARCIS (Netherlands)

van 't Hof, Femke N G; Ruigrok, Ynte M; Lee, Cue Hyunkyu; Ripke, Stephan; Anderson, Graig; de Andrade, Mariza; Baas, Annette F; Blankensteijn, Jan D; Böttinger, Erwin P; Bown, Matthew J; Broderick, Joseph; Bijlenga, Philippe; Carrell, David S; Crawford, Dana C; Crosslin, David R; Ebeling, Christian; Eriksson, Johan G; Fornage, Myriam; Foroud, Tatiana; von Und Zu Fraunberg, Mikael; Friedrich, Christoph M; Gaál, Emília I; Gottesman, Omri; Guo, Dong-Chuan; Harrison, Seamus C; Hernesniemi, Juha; Hofman, Albert; Inoue, Ituro; Jääskeläinen, Juha E; Jones, Gregory T; Kiemeney, Lambertus A L M; Kivisaari, Riku; Ko, Nerissa; Koskinen, Seppo; Kubo, Michiaki; Kullo, Iftikhar J; Kuivaniemi, Helena; Kurki, Mitja I; Laakso, Aki; Lai, Dongbing; Leal, Suzanne M; Lehto, Hanna; LeMaire, Scott A; Low, Siew-Kee; Malinowski, Jennifer; McCarty, Catherine A; Milewicz, Dianna M; Mosley, Thomas H; Nakamura, Yusuke; Nakaoka, Hirofumi; Niemelä, Mika; Pacheco, Jennifer; Peissig, Peggy L; Pera, Joanna; Rasmussen-Torvik, Laura; Ritchie, Marylyn D; Rivadeneira, Fernando; van Rij, Andre M; Santos-Cortez, Regie Lyn P; Saratzis, Athanasios; Slowik, Agnieszka; Takahashi, Atsushi; Tromp, Gerard; Uitterlinden, André G; Verma, Shefali S; Vermeulen, Sita H; Wang, Gao T; Han, Buhm; Rinkel, Gabriël J E; de Bakker, Paul I W

2016-01-01

Background--Intracranial aneurysms (IAs), abdominal aortic aneurysms (AAAs), and thoracic aortic aneurysms (TAAs) all have a familial predisposition. Given that aneurysm types are known to co-occur, we hypothesized that there may be shared genetic risk factors for IAs, AAAs, and TAAs. Methods and

Some actinide complexes of pyridin-, pyrrol-, furan- and thiophen-aldazine Schiff bases

International Nuclear Information System (INIS)

Dawod, M.M.; Khalili, F.I.; Seyam, A.M.

1990-01-01

Actinide chloride complexes with pyridinaldazine (PAA), pyrrolaldazine(PyAA-H 2 ), furanaldazine (FAA), and thiophenaldazine (TAA): An(L)Cl n ·m-H 2 O, where An = Th, UO 2 ; L PAA, PyAA-H 2 , FAA, TAA; n = 2,4; m = 0, 2, 3, 5 (also, mononuclear with 2L, dinuclear and trinuclear complexes) have been prepared by the reaction of ThCl 4 , UO 2 Cl 2 or UO 2 (Ac) 2 ·2H 2 O with PAA, PyAA-H 2 , FAA or TAA and characterized by spectral data, electrical conductance, thermal and elemental analysis. (author)

A study on the Regenerative Effect of Platelets Rich Plasma on Experimentally Induced Hepatic Damage In Albino Rats.

Science.gov (United States)

Shoeib, Heba Mamdoh; Keshk, Walaa Arafa; Foda, Abdallah Mahmoud; Abo El Noeman, Saad El-Deen Abd Elfatah

2018-02-14

Hepatic fibrosis is a worldwide health problem with significant morbidity and mortality. Currently, there is no effective therapy for hepatic fibrosis. So that the present study was aimed to evaluate the possible regenerative effect of Platelet-rich plasma (PRP) against thioacetamide (TAA) induced hepatic damage. Eighty albino rats were included; 40 were used for PRP preparation and 40 were randomly divided into four groups. Group I (control group); group II (PRP control); group III (TAA- intoxicated in a dose of 200 mg ∕ kg body weight/twice weekly for 7 weeks, intra-peritoneal and group IV (TAA-intoxicated+ PRP treated). Macrophage inflammatory protein-1α (MIP-1α) and cyclic adenosine monophosphate (cAMP) were immunoassayed in addition to peroxinitrite level, NADPH-quinine oxido-reductase-1 (NQO1) enzyme activity and liver function. PRP treatment showed significant improvement in hepatic function, decreased MIP-1α and peroxinitrite level. Meanwhile, significant increase in NQO1 enzyme activity and cAMP level were observed. The histopathological results confirmed the laboratory results with improvement of hepatic architecture except for some inflammatory cellular infiltrates. PRP has the ability to protect against TAA-induced liver damage possibly by improving redox status, liver histopathological architecture, disruption of the inflammatory and fibrotic response induced by TAA.

Syntheses, crystal structures and fluorescent properties of Cd(II), Hg(II) and Ag(I) coordination polymers constructed from 1H-1,2,4-triazole-1-acetic acid

International Nuclear Information System (INIS)

Ding Degang; Xie Lixia; Fan Yaoting; Hou Hongwei; Xu Yan

2009-01-01

Three new d 10 coordination polymers, namely [Cd(taa)Cl] n 1, [Hg(taa)Cl] n 2, and [Ag 1.5 (taa)(NO 3 ) 0.5 ] n 3 (taa=1H-1,2,4-triazole-1-acatate anion) have been prepared and characterized by elemental analysis, IR, and single crystal X-ray diffraction. Compound 1 consists of two-dimensional layers constructed by carboxyl-linked helical chains, which are further linked through carboxyl group to generate a unique 3D open framework. Topological analysis reveals that the structure of 1 can be classified as an unprecedented (3,8)-connected network with the Schlaefli symbol (4.5 2 ) 2 (4 2 .5 8 .6 14 .7 3 .8). Compound 2 manifests a doubly interpenetrated decorated α-polonium cubic network with the Schlaefli symbol of (4 10 .6 2 .8 3 ). Compound 3 consists of 2D puckered layers made up of Ag centers and taa - bridges. In addition, all of these compounds are photoluminescent in the solid state with spectra that closely resemble those of the ligand precursor. - Graphical abstract: Three new compounds based on 1H-1,2,4-triazole-1-acetic acid and Cd(II), Hg(II) and Ag(I) salts display luminescent properties and may be potential candidates for luminescent materials.

Hepato- and neuro-protective influences of biopropolis on thioacetamide-induced acute hepatic encephalopathy in rats.

Science.gov (United States)

Mostafa, Rasha E; Salama, Abeer A A; Abdel-Rahman, Rehab F; Ogaly, Hanan A

2017-05-01

Hepatic encephalopathy (HE) is a neuropsychiatric syndrome that ultimately occurs as a complication of acute or chronic liver failure; accompanied by hyperammonemia. This study aimed to evaluate the potential of biopropolis as a hepato- and neuro-protective agent using thioacetamide (TAA)-induced acute HE in rats as a model. Sixty Wistar rats were divided into 5 groups: Group 1 (normal control) received only saline and paraffin oil. Group 2 (hepatotoxic control) received TAA (300 mg/kg, once). Groups 3, 4, and 5 received TAA followed by vitamin E (100 mg/kg) and biopropolis (100 and 200 mg/kg), respectively, daily for 30 days. Evidences of HE were clearly detected in TAA-hepatotoxic group including significant elevation in the serum level of ammonia, liver functions, increased oxidative stress in liver and brain, apoptotic DNA fragmentation and overexpression of iNOS gene in brain tissue. The findings for groups administered biopropolis, highlighted its efficacy as a hepato- and neuro-protectant through improving the liver functions, oxidative status and DNA fragmentation as well as suppressing the brain expression of iNOS gene. In conclusion, biopropolis, at a dose of 200 mg/kg per day protected against TAA-induced HE through its antioxidant and antiapoptotic influence; therefore, it can be used as a protective natural product.

Density functional theory study of interactions between carbon monoxide and iron tetraaza macrocyclic complexes, FeTXTAA (X = -Cl, -OH, -OCH3, -NH2, and -NO2).

Science.gov (United States)

de Matos Mourão Neto, Isaias; Silva, Adilson Luís Pereira; Tanaka, Auro Atsushi; de Jesus Gomes Varela, Jaldyr

2017-02-01

This work describes a DFT level theoretical quantum study using the B3LYP functional with the Lanl2TZ(f)/6-31G* basis set to calculate parameters including the bond distances and angles, electronic configurations, interaction energies, and vibrational frequencies of FeTClTAA (iron-tetrachloro-tetraaza[14]annulene), FeTOHTAA (iron-tetrahydroxy-tetraaza[14]annulene), FeTOCH 3 TAA (iron- tetramethoxy-tetraaza[14]annulene), FeTNH 2 TAA (iron-tetraamino-tetraaza[14]annulene), and FeTNO 2 TAA (iron-tetranitro-tetraaza[14]annulene) complexes, as well as their different spin multiplicities. The calculations showed that the complexes were most stable in the triplet spin state (S = 1), while, after interaction with carbon monoxide, the singlet state was most stable. The reactivity of the complexes was evaluated using HOMO-LUMO gap calculations. Parameter correlations were performed in order to identify the best complex for back bonding (3d xz Fe → 2p x C and 3d yz Fe → 2p z C) with carbon monoxide, and the degree of back bonding increased in the order: FeTNO 2 TAA < FeTClTAA < FeTOHTAA < FeTOCH 3 TAA < FeTNH 2 TAA.

Uudised : Ooper. Hip-hop. Madonna

Index Scriptorium Estoniae

2005-01-01

Rumeenia sopran Nelly Miricioiu Vincenzo Bellini ooperi "Norma" nimiosas Nederlandse Operas Amsaterdamis 7.-28. märtsini. 4. märtsil Tallinna klubis Hollywood üritusel "Hip-Hop Café" New Yorgi duo Camp Lo. Ameerika poplaulja Madonna võttis vastu filmirolli

Marina Abramović on kohal / Bianka Marran

Index Scriptorium Estoniae

Marran, Bianka

2010-01-01

Jugoslaavia kunstniku Marina Abramovići performance'itest. Pikemalt tema teosest "The Artist is Present" New Yorgi Moodsa Kunsti Muuseumis 14. märtsist 31. maini 2010. Koostööst saksa fotograafi ja performance'ikunstniku Ulay'ga (kodanikunimi Frank Uwe Laysiepen)

Ritualnõi skandal / Mark Levin

Index Scriptorium Estoniae

Levin, Mark

2000-01-01

Rakvere teatrifestival "Baltoscandal 2000" : New Yorgi Wyoming Dance Theatre Projecti all tegutseva Pat Creminsi tantsuõhtu, inglase Pit Upponi kehastatud Hitler monotükis "Adolf", Oskaras Korshunovas Theatre, Marius von Mayenburgi "Tule nägu" ("The Face of Fire"), lavastaja Oskaras Korshunovas, jt.

ÜEKNi 2005. aasta peakoosolek : ESTO 2008, resolutsioon, uus esimees / foto: V. Sarapuu

Index Scriptorium Estoniae

2005-01-01

8. - 9. aprillil 2005 New Yorgis toimunud Ülemaailmse Eesti Kesknõukogu peakoosolekul kinnitati Inglismaa Eestlaste Ühingu soovil ESTO 2008 toimumise kohaks Inglismaa. Kesknõukogu uueks esimeheks valiti Jaak Juhansoo, Juhan Simonsoni vääristati Kanada eestlaste teenetemärgiga

Muusikamaailm : James Levine 25 aastat Metis. Taveneri ja MacMillani millenniumiteosed. Avafestival Sydneys / Priit Kuusk

Index Scriptorium Estoniae

Kuusk, Priit, 1938-

2000-01-01

J. Harbisoni ooperi "The Great Gatsby" esmalavastusega tähistab New Yorgi Metropolitan Opera oma 25-aastast koostööd J. Levine'iga. J. Taveneri uudisteosest "The Fall and Resurrection", J. MacMillani millenniumiteose "Magnificat" maailmaesiettekandest. 5.-26. jaan. toimuvast Sydney muusikafestivalist

Ilves urges global unity / Ella Karapetyan

Index Scriptorium Estoniae

Karapetyan, Ella

2010-01-01

President Toomas Henrik Ilves rääkis ÜRO Peaassambleel New Yorgis 24. septembril 2010 peetud kõnes Eesti abist Afganistanile, inimõigustest, küberkuritegevusest ja kinnitas Eesti toetust Gruusiale. Töövisiit Ameerika Ühendriikidesse 20.-27.09.2010

Armastus keha vastu / Katrin Kivimaa

Index Scriptorium Estoniae

Kivimaa, Katrin, 1969-

1999-01-01

Peamiselt New Yorgis tegutseva ungari-ameerika kunstniku Orshi Drozdiku (s. 1946) töödest "Medical Erotica" (1984) ja "Manufacturing the Self, Body Self" (1984-93), mida eksponeeritakse ühtse installatsioonina ja kuuluvad Budapesti kaasaegse kunsti muuseumi ehk Ludwigi muuseumi püsiekspositsiooni

Kunstituru uperpallid / Maria-Kristiina Soomre

Index Scriptorium Estoniae

Soomre, Maria-Kristiina, 1978-

2001-01-01

Jaapanlaste tekitatud kunstibuumist, mille kõrghetkeks oli 1990. a. Kunstituru peatsest jõudmisest tipphetke, pakkumistest, jaapanlaste "tagasitulekust". 10. V Sotheby oksjonil New Yorgis müüdi 1989. a. Harumuri Takamashi poolt ostetud Césanne'i "Pichet et fruits sur une table".

75 FR 43485 - Trade Adjustment Assistance for Farmers

Science.gov (United States)

2010-07-26

... Service Trade Adjustment Assistance for Farmers AGENCY: Foreign Agricultural Service, USDA. ACTION: Notice... cash benefits. FOR FURTHER INFORMATION CONTACT: Trade Adjustment Assistance for Farmers Staff, FAS... visit the TAA for Farmers' Web site: http://www.fas.usda.gov/itp/taa . Dated: July 14, 2010. John D...

75 FR 28780 - Trade Adjustment Assistance for Farmers

Science.gov (United States)

2010-05-24

... DEPARTMENT OF AGRICULTURE Foreign Agricultural Service Trade Adjustment Assistance for Farmers... Service (FAS) will begin accepting Trade Adjustment Assistance (TAA) for Farmers petitions for Fiscal Year... TAA for Farmers Program as established by Subtitle C of Title I of the Trade Act of 2002 (Pub. L. 107...

Eesti kunsti näitused Ameerikas

Index Scriptorium Estoniae

2006-01-01

23. II-12. III New Yorgis ÜRO peakorteris näitus "Käemaastikud/Handscapes". Vaadata on fotod, maalid ja installatsioonid. Kuraator Elin Kard, osalevad Jüri Ojaver, Ülle Marks, Jüri Kass, Alice Kask. 24. III-21. IV New Yorgi Eesti Majas Eesti Kultuurifondi ja Eesti kultuuripäevade näitus "Lõõm 06. Kunstidialoog: New York - Estonia". Jaanika Peerna kureeritud näitusel osalevad eesti ja ameerika kunstnikud Peeter Kolk, Dianne Bowen, Külliki Talp, Ilse Leetaru, Mark Kostabi, Paul Indrek Kostabi, Kristjan Jüris, Erika Roots, Endel Uiga, J. Peerna, Victoria Schultz, Leevi Ernits, Kristiana Pärn, Naima Rauam, Patrick Kikut, Ave Barker, Epp Kuhn, Triinu Jenas. Avamisel esilinastub J. Peenra ja Annette Solakoglu (sünd. 1968, Rootsi) lühifilm "Lõõm 06". Phoenixi Cathedral Center for the Artsis oli 3. II-1. III Anne Parmasto maalinäitus Charlotte'i aed"

Quadratic curvature terms and deformed Schwarzschild–de Sitter black hole analogues in the laboratory

Directory of Open Access Journals (Sweden)

R. da Rocha

2017-12-01

Full Text Available Sound waves on a fluid stream, in a de Laval nozzle, are shown to correspond to quasinormal modes emitted by black holes that are physical solutions in a quadratic curvature gravity with cosmological constant. Sound waves patterns in transsonic regimes at a laboratory are employed here to provide experimental data regarding generalized theories of gravity, comprised by the exact de Sitter-like solution and a perturbative solution around the Schwarzschild–de Sitter standard solution as well. Using the classical tests of General Relativity to bound free parameters in these solutions, acoustic perturbations on fluid flows in nozzles are then regarded, to study quasinormal modes of these black holes solutions, providing deviations of the de Laval nozzle cross-sectional area, when compared to the Schwarzschild solution. The fluid sonic point in the nozzle, for sound waves in the fluid, is shown to implement the acoustic event horizon corresponding to quasinormal modes. Keywords: Black holes, Fluid branes, Fluid dynamics, Quadratic curvature gravity, de Laval nozzle

Tetrahydrofuran Calpha-tetrasubstituted amino acids: two consecutive beta-turns in a crystalline linear tripeptide.

Science.gov (United States)

Maity, Prantik; Zabel, Manfred; König, Burkhard

2007-10-12

The synthesis of tetrahydrofuran Calpha-tetrasubstituted amino acids (TAAs) and their effect on the conformation in small peptides are reported. The synthesis starts from the protein amino acid methionine, which is protected at the C and N terminus and converted into the corresponding sulfonium salt by alkylation. Simple base treatment in the presence of an aryl aldehyde leads to the formation of tetrahydrofuran tetrasubstituted Calpha-amino acids in a highly diastereoselective (trans/cis ratio up to 97:3) reaction with moderate to good yields (35-78%) depending on the aldehyde used. Palladium-catalyzed coupling reactions allow a subsequent further functionalization of the TAA. The R,S,S-TAA-Ala dipeptide amide adopts a beta-turn type I conformation, whereas its S,R,S isomer does not. The R,S,S-Gly-TAA-Ala tripeptide amide shows in the solid state and in solution a conformation of two consecutive beta-turn type III structures, stabilized by i+3-->i intramolecular hydrogen bonds.

Ultrasound assisted extraction of polyphenols and their distribution in whole mung bean, hull and cotyledon.

Science.gov (United States)

Singh, Barinderjit; Singh, Narpinder; Thakur, Sheetal; Kaur, Amritpal

2017-03-01

In this study, extraction of polyphenols using different solvents (acetone, ethanol, methanol and water) with ultrasound and conventional method from whole mung bean (WMB), hull and cotyledon was conducted. Total phenolic content (TPC), total flavonoids content (TFC), total antioxidant activities (TAA), ferric reducing power (FRP) and DPPH radical scavenging activity were determined. Ultrasound treated extracts exhibited higher TPC, TFC, TAA, FRP and DPPH in different mung bean fractions than CSE. Among the solvents, acetone showed better TPC, TFC, TAA, FRP and DPPH. Hull had significantly higher TPC, TFC, TAA, FRP and DPPH than WMB and cotyledon. Sinapic acid (SA) was the major polyphenol in different fractions. Acetone extract of hull showed high polyphenol content. SA, ferulic acid, catechin, p-coumaric acid, resveratrol, quercetin and luteolin were the major contributors to antioxidant activity of acetone extract. Mung bean hull contained the maximum polyphenols and acetone was observed to be the best extraction medium for polyphenols in combination with ultrasound.

A new bonded catalyst for safe lithium-thionyl chloride batteries

Science.gov (United States)

Walsh, F.; Hopewood, J.

1982-08-01

The goal of the research effort was to demonstrate that a new class of organometallic cathode catalysts, the TAAs, are stable in thionyl chloride and that they significantly improve the power performance of lithium-thionyl chloride primary batteries. A number of TAAs were evaluated and shown to be active catalysts. Included in this evaluation were TAAs which were covalently bonded to the supporting carbon electrode material; a covalently bonded catalyst has the potential advantage that it will not dissolve into the electrolyte and negatively affect anode performance. During the six month research program, the TAAS were shown to: significantly improve cathode performance in Li/SOCl2 cells; improve cathode capacity; improve cathode performance throughout long-term tests; and not affect anode performance. Further work is needed to develop data in cell studies on temperature range, shelf life, voltage delay effects, energy/power density as a function of rate, and factors affecting electrode capacity. Battery performance in stress tests to develop safety and cost data is also needed.

75 FR 45092 - Trade Adjustment Assistance for Farmers

Science.gov (United States)

2010-08-02

... DEPARTMENT OF AGRICULTURE Foreign Agricultural Service Trade Adjustment Assistance for Farmers... Farmers Program Staff, FAS, USDA by phone: (202) 720-0638 or (202) 690- 0633; or by e-mail at: [email protected] ; or visit the TAA for Farmers' Web site: http://www.fas.usda.gov/itp/taa . Dated...

75 FR 43140 - Trade Adjustment Assistance for Farmers

Science.gov (United States)

2010-07-23

... DEPARTMENT OF AGRICULTURE Foreign Agricultural Service Trade Adjustment Assistance for Farmers... Assistance for Farmers Staff, FAS, USDA, by phone: (202) 720-0638, or (202) 690-0633; or by e-mail: [email protected] ; or visit the TAA for Farmers' Web site: http://www.fas.usda.gov/itp/taa . Dated...

Tee Kilkennysse läheb läbi... Liivalaia / William Elliott ; tõlk. Marek Laane

Index Scriptorium Estoniae

Elliott, William

2005-01-01

Suurbritannia diplomaat rõhutab vajadust tunda hästi olukorda selles riigis, mida hakatakse rajama või taas üles ehitama. Ta esitab kolm teesi, mida peaks silmas pidama riigi taasülesehitusel. Nn. riskiriikidega diplomaatiliste sidemete säilitamise tähtsusest. Lisa: Rumalaid diplomaatilistest suhetest loobumisi

Association of human liver bilirubin UDP-glucuronyltransferase activity with a polymorphism in the promoter region of the UGT1A1 gene

NARCIS (Netherlands)

Raijmakers, MTM; Jansen, PLM; Steegers, EAP; Peters, WHM

Background/Aims: Gilbert's syndrome is a benign form of a deficiency in bilirubin glucuronidation. It is associated with a homozygous polymorphism, A(TA)(7)TAA instead of A(TA)(6)TAA, in the TATA-box of the promoter region of the bilirubin UDP-glucuronyltransferase gene. In this study the

Increasing vaccine potency through exosome antigen targeting.

Science.gov (United States)

Hartman, Zachary C; Wei, Junping; Glass, Oliver K; Guo, Hongtao; Lei, Gangjun; Yang, Xiao-Yi; Osada, Takuya; Hobeika, Amy; Delcayre, Alain; Le Pecq, Jean-Bernard; Morse, Michael A; Clay, Timothy M; Lyerly, Herbert K

2011-11-21

While many tumor associated antigens (TAAs) have been identified in human cancers, efforts to develop efficient TAA "cancer vaccines" using classical vaccine approaches have been largely ineffective. Recently, a process to specifically target proteins to exosomes has been established which takes advantage of the ability of the factor V like C1C2 domain of lactadherin to specifically address proteins to exosomes. Using this approach, we hypothesized that TAAs could be targeted to exosomes to potentially increase their immunogenicity, as exosomes have been demonstrated to traffic to antigen presenting cells (APC). To investigate this possibility, we created adenoviral vectors expressing the extracellular domain (ECD) of two non-mutated TAAs often found in tumors of cancer patients, carcinoembryonic antigen (CEA) and HER2, and coupled them to the C1C2 domain of lactadherin. We found that these C1C2 fusion proteins had enhanced expression in exosomes in vitro. We saw significant improvement in antigen specific immune responses to each of these antigens in naïve and tolerant transgenic animal models and could further demonstrate significantly enhanced therapeutic anti-tumor effects in a human HER2+ transgenic animal model. These findings demonstrate that the mode of secretion and trafficking can influence the immunogenicity of different human TAAs, and may explain the lack of immunogenicity of non-mutated TAAs found in cancer patients. They suggest that exosomal targeting could enhance future anti-tumor vaccination protocols. This targeting exosome process could also be adapted for the development of more potent vaccines in some viral and parasitic diseases where the classical vaccine approach has demonstrated limitations. Copyright © 2011 Elsevier Ltd. All rights reserved.

Induced pluripotent stem cells: challenges and opportunities for cancer immunotherapy.

Science.gov (United States)

Sachamitr, Patty; Hackett, Simon; Fairchild, Paul Jonathan

2014-01-01

Despite recent advances in cancer treatment over the past 30 years, therapeutic options remain limited and do not always offer a cure for malignancy. Given that tumor-associated antigens (TAA) are, by definition, self-proteins, the need to productively engage autoreactive T cells remains at the heart of strategies for cancer immunotherapy. These have traditionally focused on the administration of autologous monocyte-derived dendritic cells (moDC) pulsed with TAA, or the ex vivo expansion and adoptive transfer of tumor-infiltrating lymphocytes (TIL) as a source of TAA-specific cytotoxic T cells (CTL). Although such approaches have shown some efficacy, success has been limited by the poor capacity of moDC to cross present exogenous TAA to the CD8(+) T-cell repertoire and the potential for exhaustion of CTL expanded ex vivo. Recent advances in induced pluripotency offer opportunities to generate patient-specific stem cell lines with the potential to differentiate in vitro into cell types whose properties may help address these issues. Here, we review recent success in the differentiation of NK cells from human induced pluripotent stem (iPS) cells as well as minor subsets of dendritic cells (DCs) with therapeutic potential, including CD141(+)XCR1(+) DC, capable of cross presenting TAA to naïve CD8(+) T cells. Furthermore, we review recent progress in the use of TIL as the starting material for the derivation of iPSC lines, thereby capturing their antigen specificity in a self-renewing stem cell line, from which potentially unlimited numbers of naïve TAA-specific T cells may be differentiated, free of the risks of exhaustion.

Induced pluripotent stem cells: Challenges and opportunities for cancer immunotherapy

Directory of Open Access Journals (Sweden)

Patty eSachamitr

2014-04-01

Full Text Available Despite recent advances in cancer treatment over the past 30 years, therapeutic options remain limited and do not always offer a cure for malignancy. Given that tumour associated antigens (TAA are, by definition, self-proteins, the need to productively engage autoreactive T cells remains at the heart of strategies for cancer immunotherapy. These have traditionally focussed on the administration of autologous monocyte-derived dendritic cells (moDC pulsed with TAA, or the ex vivo expansion and adoptive transfer of tumour infiltrating lymphocytes (TIL as a source of TAA-specific cytotoxic T cells (CTL. Although such approaches have shown some efficacy, success has been limited by the poor capacity of moDC to cross-present exogenous TAA to the CD8+ T cell repertoire and the potential for exhaustion of CTL expanded ex vivo. Recent advances in induced pluripotency offer opportunities to generate patient-specific stem cell lines with the potential to differentiate in vitro into cell types whose properties may help address these issues. Here we review recent success in the differentiation of NK cells from human induced pluripotent stem (iPS cells as well as minor subsets of DC with therapeutic potential, including CD141+XCR1+ DC, capable of cross-presenting TAA to naïve CD8+ T cells. Furthermore, we review recent progress in the use of TIL as the starting material for the derivation of iPSC lines, thereby capturing their antigen specificity in a self-renewing stem cell line, from which potentially unlimited numbers of naïve TAA-specific T cells may be differentiated, free of the risks of exhaustion.

Combined effect of regulatory polymorphisms on transcription of UGT1A1 as a cause of Gilbert syndrome

Directory of Open Access Journals (Sweden)

Sato Hiroshi

2010-06-01

Full Text Available Abstract Background Gilbert syndrome is caused by defects in bilirubin UDP-glucuronosyltransferase (UGT1A1. The most common variation believed to be involved is A(TA7TAA. Although several polymorphisms have been found to link with A(TA7TAA, the combined effect of regulatory polymorphisms in the development of Gilbert syndrome remains unclear. Methods In an analysis of 15 patients and 60 normal subjects, we detected 14 polymorphisms and nine haplotypes in the regulatory region. We classified the 4-kbp regulatory region of the patients into: the TATA box including A(TA7TAA; a phenobarbital responsive enhancer module including c.-3275T>G; and a region including other ten linked polymorphisms. The effect on transcription of these polymorphisms was studied. Results All haplotypes with A(TA7TAA had c.-3275T>G and additional polymorphisms. In an in-vitro expression study of the 4-kbp regulatory region, A(TA7TAA alone did not significantly reduce transcription. In contrast, c.-3275T>G reduced transcription to 69% of that of wild type, and the linked polymorphisms reduced transcription to 88% of wild type. Transcription of the typical regulatory region of the patients was 56% of wild type. Co-expression of constitutive androstane receptor (CAR increased the transcription of wild type by a factor of 4.3. Each polymorphism by itself did not reduce transcription to the level of the patients, however, even in the presence of CAR. Conclusions These results imply that co-operation of A(TA7TAA, c.-3275T>G and the linked polymorphisms is necessary in causing Gilbert syndrome.

Tappa Rasputin ja asutada moemaja / Ilona Martson

Index Scriptorium Estoniae

Martson, Ilona, 1970-

2009-01-01

Vene emigrantide loodud moest 20. saj. esimesel poolel. Venemaalt Londonisse ja hiljem Pariisi emigreerunud suurvürstinna Maria Pavlovna Romanova tikkimisateljeest "Kitmir", koostööst Coco Chaneliga. Pariisis tegutsenud vürst Felix Jussupovi moemajast "Irfe". Valentina Sanina Schlee moemajast "Valentina Gowns" New Yorgis

Ermitaazh läheb Amsterdami / Rael Artel

Index Scriptorium Estoniae

Artel, Rael, 1980-

2003-01-01

Peterburi Ermitaazhi filiaali avamisest Amstelhofis Hollandis. Avanäitusel veebruaris 2004 saab tutvuda ligi sajakonna Musta mere regioonist pärit antiikkreeka kuldehtega. Filiaali rajamise II faasist. Ermitaazhil on toad Somerset House'is Londonis, kollektsioonide jagamise leping Guggenheimiga New Yorgis ja Kunsthistorisches Museumiga Viinis

Russian filmmaker comes home / Boris Frumin ; interv. Paul Morton

Index Scriptorium Estoniae

Frumin, Boris

2006-01-01

Riias sündinud, 70ndate lõpul USA-sse emigreerunud filmitegija, New Yorgi ülikooli professor, kes asus Tallinna Ülikooli all tegutsevas Balti Filmi- ja Meediakoolis tööle filmi magistriõppe juhina ja rezhissuuri suuna põhiõppejõuna, endast

Psühhodraama - spontaansuse kool / Taimi Elenurm

Index Scriptorium Estoniae

Elenurm, Taimi

2010-01-01

Viinis ja New Yorgis tegutsenud psühhiaatri Jakob Levy Moreno loodud psühhodraamast, mis võimaldab rollimängu kaudu näha ennast läbi teiste silmade, aga ka vabaneda pingetest andes võimaluse käituda teisiti kui tavaelus

Uudised

Index Scriptorium Estoniae

2005-01-01

New Yorgi hip-hop-trio De La Soul 3. sept. Tartus ööklubis Tallinn. Briti rockbändi Coldplay soovist Eestis esineda. Ansambel The Cure aitas oma allkirjadega kaasa valgevene teadlase Juri Bandazhevski vanglast vabastamisele. Suri ameerika süntesaatorite valmistaja Robert Moog

Uudised : Muusika. Kontsert. Muusikal

Index Scriptorium Estoniae

2005-01-01

Hans Christian Anderseni elulool põhineva Stephin Merritt'i ooperist "My Life as a Fairy Tale" (lavastuse esietendus New Yorgi Lincoln Centeri festivalil juuli lõpus). Duubelplaadist "Two Chinese Operas". Autorilaulufestivalist "Mailaul" 20. ja 21.mail Tartus. Inglismaal esilinastunud muusikalist "Billy Elliott" (helilooja Elton John)

Ameerika 11. septembri haavad hakkavad tasapisi kinni kasvama / Neeme Raud

Index Scriptorium Estoniae

Raud, Neeme, 1969-

2007-01-01

Ilmunud ka: Postimees : na russkom jazõke, 11. sept. 2007, lk. 7. 2001. aastal 11. septembril toimunud New Yorgi kaksiktornide ründamisest ja kavas olevast mälestustseremooniast. Lisa: 541-meetrine vabadustorn; 2001. aasta 11. september sünnitas rea veriseid sündmusi

Mies kahes muuseumis korraga / Maria-Kristiina Soomre

Index Scriptorium Estoniae

Soomre, Maria-Kristiina, 1978-

2001-01-01

2001. a. suvel avab New Yorgi Museum of Modern Art arhitekt Ludwig Mies van der Rohe algusaastate tööle keskenduva näituse "Mies in Berlin" ja Whitney Museum of American Art arhitekti ameerika perioodi kajastava näituse "Mies in America".

View from the UN Balts weigh in at general debate / Ann Charles

Index Scriptorium Estoniae

Charles, Ann

2008-01-01

Eesti presidendi Toomas Hendrik Ilvese, Läti presidendi Valdis Zatlersi, Leedu presidendi Valdas Adamkuse, Ukraina presidendi Viktor Juštšenko ja Prantsusmaa presidendi Nicolas Sarkozy sõnavõttudest ÜRO peaassambleel. Vabariigi President töövisiidil New Yorgis 23.-27.09.2008

President Arnold Rüütel andis president George W. H. Bushile üle Maarjamaa Risti / Kärt Ulman

Index Scriptorium Estoniae

Ulman, Kärt

2005-01-01

President Arnold Rüütel andis New Yorgis endisele USA presidendile Georg Bushile Eesti iseseisvuspüüdluste toetamise eest Maarjamaa Risti I klassi ordeni. Vt. samas lühiintervjuud president George W. H. Bushiga. Töövisiit New Yorki 13.-17.09.2005

Rekordhind Cezanne'i eest

Index Scriptorium Estoniae

1999-01-01

Paul Cezanne'i 1893. a. maalitud natüürmort "Traperii, kruus ja puuviljavaagen" müüdi New Yorgi Sotheby's oksjonil üle 700 miljoni krooni eest. Georges Seurat' "Vaade La Grande-Jatte'i saarele" (1884) müüdi ligemale 504 miljoni krooniga.

A thioacetamide-induced hepatic encephalopathy model in C57BL/6 mice: a behavioral and neurochemical study Modelo de encefalopatia hepática induzida por tioacetamida em camundongos C57BL/6: estudo comportamental e neuroquímico

Directory of Open Access Journals (Sweden)

Aline Silva de Miranda

2010-08-01

Full Text Available OBJECTIVE: Hepatic encephalopathy (HE is a neuropsychiatric syndrome resulting from liver failure. In the present study, we aimed to standardize an animal model of HE induced by thioacetamide (TAA in C57BL/6 mice evaluating behavioral symptoms in association with liver damage and alterations in neurotransmitter release. METHOD: HE was induced by an intraperitoneal single dose of TAA (200 mg/kg, 600 mg/kg or 1,200 mg/kg. Behavioral symptoms were evaluated using the SHIRPA battery. Liver damage was confirmed by histopathological analysis. The glutamate release was measured using fluorimetric assay. RESULTS: The neuropsychiatric state, motor behavior and reflex and sensory functions were significantly altered in the group receiving 600 mg/kg of TAA. Biochemical analysis revealed an increase in the glutamate release in the cerebral cortex of HE mice. CONCLUSION: HE induced by 600mg/kg TAA injection in C57BL/6 mice seems to be a suitable model to investigate the pathogenesis and clinical disorders of HE.OBJETIVO: A encefalopatia hepática (EH é uma síndrome neuropsiquiátrica resultante da falência hepática. O objetivo do presente estudo foi estabelecer um modelo de EH induzida por tioacetamida (TAA em camundongos C57BL/6 avaliando transtornos comportamentais, falência hepática e alterações na liberação de neurotransmissores. MÉTODO: A EH foi induzida por meio de uma única dose intraperitoneal de TAA (200 mg/kg, 600 mg/kg, 1.200 mg/kg. As alterações comportamentais foram avaliadas utilizando a bateria SHIRPA. A falência hepática foi confirmada através de análises histopatológicas e a liberação de glutamato medida, por ensaio fluorimétrico. RESULTADOS: Foram encontradas alterações significativas no estado neuropsiquiátrico, comportamento motor e função reflexa e sensorial no grupo que recebeu 600 mg/kg de TAA. Análises bioquímicas revelaram aumento na liberação de glutamato no córtex cerebral dos camundongos com EH

Separation of monoglycosides from fruit juice by diafiltration

DEFF Research Database (Denmark)

Jensen, Morten Busch; Christensen, Knud Villy; Norddahl, Birgir

The process of separating sugars from anthocyanins in black currant juice has been investigated. Diafiltration on a laboratory scale flat sheet module (Labstk M20, Alfa Laval Nakskov A/S, Denmark) loaded with an ultrafiltration membrane (ETNA01-PP, MWCO = 1,000 Da, Alfa Laval Nakskov A/S, Denmark......) with a total installed area of 0.25 squaremeters distributed on 14 sheets showed good retention of anthocyanins as compared to fructose and glucose. In order to investigate whether the different flow pattern in a commercial size module would affect separation experiments were conducted with the same membrane...

Blood pharmacokinetics of tertiary amyl methyl ether in male and female F344 rats and CD-1 mice after nose-only inhalation exposure.

Science.gov (United States)

Sumner, Susan C J; Janszen, Derek B; Asgharian, Bahman; Moore, Timothy A; Bobbitt, Carol M; Fennell, Timothy R

2003-01-01

Interest in understanding the biological behavior of aliphatic ethers has increased owing to their use as gasoline additives. The purpose of this study was to investigate the blood pharmacokinetics of the oxygenate tertiary amyl methyl ether (TAME), its major metabolite tertiary amyl alcohol (TAA) and acetone in rats and mice following inhalation exposure to TAME. Species differences in the area under the curve (AUC) for TAME were significant at each exposure concentration. For rats, the blood TAME AUC increased in proportion with an increase in exposure concentration. For mice, an increase in exposure concentration (100-500 ppm) resulted in a disproportional increase in the TAME AUC. Mice had greater (two- to threefold) blood concentrations of TAA compared with rats following exposure to 2500 or 500 ppm TAME. Mice had a disproportional increase in the TAA AUC with an increase in exposure concentration (100-500 ppm). This difference could result from saturation of a process (e.g. oxidation, glucuronide conjugation) that is involved in the further metabolism of TAA. For each species, gender and exposure concentration, acetone increased during exposure and returned to control values by 16 h following exposure. The source of acetone could be both as a metabolite of TAA or an effect on endogenous metabolism produced by exposure to TAME. Copyright 2003 John Wiley & Sons, Ltd.

Architecturally Significant Requirements Identification, Classification and Change Management for Multi-tenant Cloud-Based Systems

DEFF Research Database (Denmark)

Chauhan, Muhammad Aufeef; Probst, Christian W.

2017-01-01

presented a framework for requirements classification and change management focusing on distributed Platform as a Service (PaaS) and Software as a Service (SaaS) systems as well as complex software ecosystems that are built using PaaS and SaaS, such as Tools as a Service (TaaS). We have demonstrated...

77 FR 31880 - Operating Instructions for Implementing the Amendments to the Trade Act of 1974 Enacted by the...

Science.gov (United States)

2012-05-30

... apply for TAA benefits and services with Office of Trade Adjustment Assistance (OTAA) in the Department... criteria that test whether the group of workers was adversely affected by international trade have been met..., added to the TAA program in 1993 to provide benefits to workers who lost their jobs because of trade...

Megakorter metropolis / Lara Sargent

Index Scriptorium Estoniae

Sargent, Lara

2008-01-01

Miljonärist kunstikollektsionääri viiel korrusel paiknev kodu New Yorgis. Juurde ehitati kümnes korrus. Katusekorter on mõeldud kaasaegse kunsti kollektsiooni eksponeerimiseks. Korteri kavandas itaalia arhitekt Andrea Ballerini. Köögimööbel tehti eritellimusel. 12 värv. vaadet

Muusikauudiseid maailmast / Nele-Eva Steinfeld

Index Scriptorium Estoniae

Steinfeld, Nele-Eva

2015-01-01

Lühisõnumeid maailmast: Grammy võitjad selgunud. Suri metsosoproan Jelena Obraztsova. Dubaisse kerkib läbipaistev ooperimaja. Lahkus pianist Aldo Ciccolini. Alan Gilbert lahkub New Yorgi Filharmoonikute juurest. Šveitsi-Romaani orkestri uueks peadirigendiks saab Jonathan Nott. Taani kammerorkester loodab "Hooandja"-laadsele toetussüsteemile jne.

Oriana Fallaci viha ja raev / Urmas Kiil

Index Scriptorium Estoniae

Kiil, Urmas

2006-01-01

Ajakirjanik ja kirjanik Oriana Fallaci, kelle artikkel New Yorgis toimunud terrorirünnaku muljetest avaldati 29. sept. 2001. a. Itaalia juhtivas ajalehes Corriere della sera, avaldas peagi raamatu "Raev ja uhkus" (The Rage and Pride). Raamatus mõistab ta islamimaailma mööndusteta tervikuna hukka

Betooniaeg - betoon interjööris / Maris Kerge, Kadri Kerge

Index Scriptorium Estoniae

Kerge, Maris

2005-01-01

Kolme näite varal - New Yorgi JFK lennujaama kuues terminal (arhitekt Eero Saarinen), City Plaza söökla (Pille Lausmäe sisearhitektuuribüroo), eramu Veskimöldres (arhitek Andres Alver) - betooni kasutusvõimalustest interjööris. 5 värv. ill

Feminism on ka praegu hädavajalik mõtteviis / Reet Varblane

Index Scriptorium Estoniae

Varblane, Reet, 1952-

2006-01-01

1985. a. New Yorgis loodud gorillamaski ning ajalooliste naiskunstnike nimedega varjatud naiskunstnike-feministide rühmitusest Guerilla Girls. 2005. a. osales rühmitus Veneetsia biennaalil. Üks rühmituse asutajaliikmeist naiskunstnike ja mustanahaliste kunstnike olukorrast praeguses Ameerika kunstimaailmas, rühmituse kunstist, poliitilisest kunstist jm.

Kunstnik oligi kohal / Maria-Kristiina Soomre

Index Scriptorium Estoniae

Soomre, Maria-Kristiina, 1978-

2010-01-01

Marina Abramovići retrospektiiv "Kunstnik on kohal" ("The artist is Present") New Yorgi moodsa kunsti muuseumis 14. märtsist 31. maini 2010. Näitusel saatsid originaalesituste foto- ja videodokumentatsioone valitud teoste live-taasesitused. Kunstnik oli näituse nimiteoses kohal füüsiliselt

Eesti rahvusvärvid homokunsti näitusel

Index Scriptorium Estoniae

1998-01-01

Amsterdami moodsa ja kaasaegse kunsti muuseum Stedelijk näitab 23. augustini homokunsti analüüsivat teemanäitust "From the Corner of the Eye". New Yorgi kunstnik Nicole Eisenman on oma töös kasutanud väikseid Eesti jt. väikeriikide lippe

Kurat, kus sa küll täna õhtul oled? / Tristan Priimägi

Index Scriptorium Estoniae

Priimägi, Tristan, 1976-

2009-01-01

Martin Scorsese muusikalisest dokumentaalfilmist "Shine a Light - Valgus peale" (USA - Suurbritannia, 2008), mille keskmes on 2006.a. New Yorgi Beaconi teatris toimunud briti ansambli Rolling Stones kontsert. Ka varasematest filmidest selle ansambli kohta (Jean-Luc Godard'i "Symphaty for the Devil", Albert ja David Mayslesi "Gimme Shelter")

Ameerika teatri suurkuju Ellen Stewart "Puhastuse" esietenduseni ei elanud / Andres Laasik

Index Scriptorium Estoniae

Laasik, Andres, 1960-2016

2011-01-01

13. jaanuaril 2011 New Yorgis surnud Ellen Stewartist, kes 1961. a. asutas oma teatri La Mama Experimental Theatre Clubi. La Mamas mängitud eesti autorite näidenditest ja lavastustest. Sofi Oksaneni "Puhastuse" lavastas La Mamas Zishan Ugurlu. Näitekirjanik Edward Albee teatrijuhist Ellen Stewartist

Peter Halley / Peter Halley ; interv. Tilman Baumgärtel

Index Scriptorium Estoniae

Halley, Peter

2006-01-01

Ameerika maalikunstnikust Peter Halley'st (sünd. 1953) ja tema loomingust, intervjuu kunstnikuga tema New Yorgi ateljees 30. XII 1999. Peter Halley võrgustikke kujutavatest maalidest, elektroonilise teadetetahvli The Thing ja Moodsa Kunsti Muuseumi veebilehekülje jaoks tehtud digitaalsetest töödest ning muust

New insights into nucleation. Pressure trace measurements and the first small angle X-ray scattering experiments in a supersonic laval nozzle

Energy Technology Data Exchange (ETDEWEB)

Ghosh, D.

2007-07-01

Homogeneous nucleation rates of the n-alcohols and the n-alkanes have been determined by combining information from two sets of supersonic Laval nozzle expansion experiments under identical conditions. The nucleation rates J=N/{delta}t{sub Jmax} for the n-alcohols are in the range of 1.10{sup 17}

Comparison of early treatment with low doses of nilotinib, imatinib and a clinically relevant dose of silymarin in thioacetamide-induced liver fibrosis.

Science.gov (United States)

Shaker, Mohamed E; Shiha, Gamal E; Ibrahim, Tarek M

2011-11-30

Our previous study has already confirmed a promising anti-fibrotic activity especially for nilotinib; when given at a daily dose of 10 mg/kg during the last 4 weeks of thioacetamide (TAA)-induced liver fibrosis for 12 weeks in rats. Therefore, this study was carried out to compare the prophylactic potential of low dose of nilotinib to that of its predecessor, imatinib, and a clinically relevant dose of the standard hepatoprotective treatment, silymarin, in TAA-intoxication. Male Wistar rats received intraperitoneal injections of TAA (150 mg/kg, twice weekly) for 8 weeks, as well as oral treatments with imatinib (5 mg/kg/day), nilotinib (5 mg/kg/day) and silymarin (50 mg/kg/day) from the first day of TAA-intoxication. At the end of the study, chronic hepatic injury was evaluated by analysis of liver function tests in serum. Hepatic oxidative stress was assessed by measuring malondialdehyde, 4-hydroxynonenal, total nitrate/nitrite and reduced glutathione contents, as well as myeloperoxidase and superoxide dismutase activities. Hepatic fibrosis was evaluated by histopathology and collagen content. Our results suggest that the prophylactic potential of nilotinib (5 mg/kg/day), imatinib (5mg/kg/day) and silymarin (50 mg/kg/day) in TAA-intoxication for 8 weeks is lower than the late treatments of nilotinib (10 mg/kg/day), imatinib (10mg/kg/day) and silymarin (100 mg/kg/day) during the last 4 weeks of TAA-intoxication for 12 weeks in rats. Taken together, this study suggests that nilotinib may have higher anti-fibrotic activity when administered at a significant stage of fibrosis as a result of impairment of its metabolism in the fibrotic livers. Copyright © 2011 Elsevier B.V. All rights reserved.

Nilotinib counteracts thioacetamide-induced hepatic oxidative stress and attenuates liver fibrosis progression.

Science.gov (United States)

Shaker, Mohamed E; Salem, Hatem A; Shiha, Gamal E; Ibrahim, Tarek M

2011-04-01

The aim of this study was to evaluate and compare the effects of imatinib and nilotinib to that of silymarin on established liver fibrosis and oxidative stress in a thioacetamide (TAA) rat model. Male Wistar rats received intraperitoneal (i.p.) injections of TAA (150mg/kg, twice weekly) for 12weeks. Daily treatments with imatinib (10mg/kg), nilotinib (10mg/kg), and silymarin (100mg/kg) were administered orally during the last 4weeks of TAA-administration. At the end of the study, hepatic damage was evaluated by analysis of liver function tests in serum. Hepatic histopathology and collagen content were employed to quantify liver fibrosis. Hepatic oxidative stress was assessed by measuring malondialdehyde (MDA), 4-hydroxynonenal (4-HNE), total nitrate/nitrite (NOx), and reduced glutathione (GSH) contents, as well as myeloperoxidase (MPO) and superoxide dismutase (SOD) activities. Nilotinib, silymarin and, to a lesser extent, imatinib treatments ameliorated TAA-induced hepatic oxidative stress and damage as indicated by hepatic MDA, 4-HNE, NOx, GSH, MPO and SOD levels, as well as liver function tests. Hepatic histopathology results revealed that nilotinib, imatinib, and silymarin treatments decreased the mean score of fibrosis in TAA-treated rats by 24, 14, and 3%, respectively. However, nilotinib and silymarin, but not imatinib, treatments decreased hepatic collagen content in TAA-treated rats by 17 and 36%, respectively. In conclusion, we demonstrated for the first time that nilotinib not only protected against hepatic oxidative stress, but also slowed down liver fibrosis progression. Thus, we provide the first evidence that nilotinib might be a promising anti-fibrotic drug. © 2010 The Authors Fundamental and Clinical Pharmacology © 2010 Société Française de Pharmacologie et de Thérapeutique.

Increased serum bile acid concentration following low-dose chronic administration of thioacetamide in rats, as evidenced by metabolomic analysis

Energy Technology Data Exchange (ETDEWEB)

Jeong, Eun Sook; Kim, Gabin; Shin, Ho Jung [Department of Pharmacology and Pharmacogenomics Research Center, Inje University, College of Medicine, Bokjiro 75, Busanjin-Gu, Busan 614-735 (Korea, Republic of); Park, Se-Myo; Oh, Jung-Hwa; Kim, Yong-Bum; Moon, Kyoung-Sik [Korea Institute of Toxicology, 141 Gajeong-ro, Yuseong-gu, Daejeon 305-343 (Korea, Republic of); Choi, Hyung-Kyoon [College of Pharmacy, Chung-Ang University, Seoul (Korea, Republic of); Jeong, Jayoung [Ministry of Food and Drug Safety, Osong-eup, Heungdeok-gu, Cheongju-si, Chungcheongbuk-do 361-951 (Korea, Republic of); Shin, Jae-Gook [Department of Pharmacology and Pharmacogenomics Research Center, Inje University, College of Medicine, Bokjiro 75, Busanjin-Gu, Busan 614-735 (Korea, Republic of); Kim, Dong Hyun, E-mail: dhkim@inje.ac.kr [Department of Pharmacology and Pharmacogenomics Research Center, Inje University, College of Medicine, Bokjiro 75, Busanjin-Gu, Busan 614-735 (Korea, Republic of)

2015-10-15

A liquid chromatography/time-of-flight mass spectrometry (LC/TOF-MS)-based metabolomics approach was employed to identify endogenous metabolites as potential biomarkers for thioacetamide (TAA)-induced liver injury. TAA (10 and 30 mg/kg), a well-known hepatotoxic agent, was administered daily to male Sprague–Dawley (SD) rats for 28 days. We then conducted untargeted analyses of endogenous serum and liver metabolites. Partial least squares discriminant analysis (PLS-DA) was performed on serum and liver samples to evaluate metabolites associated with TAA-induced perturbation. TAA administration resulted in altered levels of bile acids, acyl carnitines, and phospholipids in serum and in the liver. We subsequently demonstrated and confirmed the occurrence of compromised bile acid homeostasis. TAA treatment significantly increased serum levels of conjugated bile acids in a dose-dependent manner, which correlated well with toxicity. However, hepatic levels of these metabolites were not substantially changed. Gene expression profiling showed that the hepatic mRNA levels of Ntcp, Bsep, and Oatp1b2 were significantly suppressed, whereas those of basolateral Mrp3 and Mrp4 were increased. Decreased levels of Ntcp, Oatp1b2, and Ostα proteins in the liver were confirmed by western blot analysis. These results suggest that serum bile acids might be increased due to the inhibition of bile acid enterohepatic circulation rather than increased endogenous bile acid synthesis. Moreover, serum bile acids are a good indicator of TAA-induced hepatotoxicity. - Highlights: • Endogenous metabolic profiles were assessed in rat after treatment of thioacetamide. • It significantly increased the levels of bile acids in serum but not in the liver. • Expression of the genes related to bile acid secretion and reuptake was decreased. • Increased serum bile acids result from block of enterohepatic circulation of bile acids.

Comparison of amino acid digestibility of feed ingredients in broilers, laying hens and caecectomised roosters.

Science.gov (United States)

Adedokun, S A; Utterback, P; Parsons, C M; Adeola, O; Lilburn, M S; Applegate, T J

2009-05-01

1. This study determined the effect of bird type (broilers, laying hens, or caecectomised roosters) on amino acid digestibility of feedstuffs from 5 plant sources and one animal source. 2. The standardised amino acid digestibility (SAAD) were obtained by correcting apparent ileal amino acid digestibility (AIAAD) values for basal ileal endogenous amino acid (EAA) flow obtained by feeding a N-free diet (NFD) to broilers and laying hens or from fasted EAA flow from caecectomised roosters. 3. The apparent total amino acid (TAA) digestibilities did not differ between broilers and roosters for three of the 6 feed ingredients. 4. Broilers had higher apparent total amino acid (TAA) digestibility than laying hens and roosters when fed on the maize diet (canola meal, maize, and soybean meal). 5. The apparent TAA digestibilities were similar across bird types for the dark distillers' dried grain with solubles, but the apparent lysine digestibility was much lower in the caecectomised roosters (15%) than the broilers (49%) and laying hens (43%). 6. The standardised TAA digestibility values in roosters were higher than in broilers for three of the 6 feed ingredients (canola meal, soybean meal, or meat and bone meal). 7. There were no differences between broilers and roosters, however, in the standardised TAA digestibility values for maize, dark and light DDGS. 8. The standardised TAA digestibility values for laying hens were lower for maize, higher for meat and bone meal, but no different for the remaining ingredients when compared with broilers. 9. The results from this study showed that both the apparent and standardised amino acid digestibility values in caecectomised roosters, laying hens, and broilers ingredients are similar for some, but not all, feed ingredients. 10. Nutritionists should, therefore, be cautious about using digestibility coefficients obtained by different methodologies as values may differ.

Increased serum bile acid concentration following low-dose chronic administration of thioacetamide in rats, as evidenced by metabolomic analysis

International Nuclear Information System (INIS)

Jeong, Eun Sook; Kim, Gabin; Shin, Ho Jung; Park, Se-Myo; Oh, Jung-Hwa; Kim, Yong-Bum; Moon, Kyoung-Sik; Choi, Hyung-Kyoon; Jeong, Jayoung; Shin, Jae-Gook; Kim, Dong Hyun

2015-01-01

A liquid chromatography/time-of-flight mass spectrometry (LC/TOF-MS)-based metabolomics approach was employed to identify endogenous metabolites as potential biomarkers for thioacetamide (TAA)-induced liver injury. TAA (10 and 30 mg/kg), a well-known hepatotoxic agent, was administered daily to male Sprague–Dawley (SD) rats for 28 days. We then conducted untargeted analyses of endogenous serum and liver metabolites. Partial least squares discriminant analysis (PLS-DA) was performed on serum and liver samples to evaluate metabolites associated with TAA-induced perturbation. TAA administration resulted in altered levels of bile acids, acyl carnitines, and phospholipids in serum and in the liver. We subsequently demonstrated and confirmed the occurrence of compromised bile acid homeostasis. TAA treatment significantly increased serum levels of conjugated bile acids in a dose-dependent manner, which correlated well with toxicity. However, hepatic levels of these metabolites were not substantially changed. Gene expression profiling showed that the hepatic mRNA levels of Ntcp, Bsep, and Oatp1b2 were significantly suppressed, whereas those of basolateral Mrp3 and Mrp4 were increased. Decreased levels of Ntcp, Oatp1b2, and Ostα proteins in the liver were confirmed by western blot analysis. These results suggest that serum bile acids might be increased due to the inhibition of bile acid enterohepatic circulation rather than increased endogenous bile acid synthesis. Moreover, serum bile acids are a good indicator of TAA-induced hepatotoxicity. - Highlights: • Endogenous metabolic profiles were assessed in rat after treatment of thioacetamide. • It significantly increased the levels of bile acids in serum but not in the liver. • Expression of the genes related to bile acid secretion and reuptake was decreased. • Increased serum bile acids result from block of enterohepatic circulation of bile acids.

Genetic variants in FBN-1 and risk for thoracic aortic aneurysm and dissection.

Science.gov (United States)

Iakoubova, Olga A; Tong, Carmen H; Rowland, Charles M; Luke, May M; Garcia, Veronica E; Catanese, Joseph J; Moomiaie, Remo M; Sotonyi, Peter; Ascady, Gyorgy; Nikas, Demitrios; Dedelias, Panagiotis; Tranquilli, Maryann; Elefteriades, John A

2014-01-01

A recent genome wide association study (GWAS) by LeMaire et al. found that two single nucleotide polymorphisms (SNPs), rs2118181 and rs10519177 in the FBN-1 gene (encoding Fibrillin-1), were associated with thoracic aortic dissection (TAD), non-dissecting thoracic aortic aneurysm (TAA), and thoracic aortic aneurysm or dissection (TAAD); the largest effect was observed for the association of rs2118181 with TAD. We investigated whether rs2118181 and rs10519177 were associated with TAD, TAA, and TAAD in the Yale study. The genotypes of rs2118181 and rs10519177 were determined for participants in the Yale study: 637 TAAD cases (140 TAD, 497 TAA) and 275 controls from the United States, Hungary, and Greece. The association of the genotypes with TAD, TAA and TAAD were assessed using logistic regression models adjusted for sex, age, study center and hypertension. In the Yale study, rs2118181 was associated with TAD: compared with non-carriers, carriers of the risk allele had an unadjusted odds ratio for TAD of 1.80 (95% CI 1.15-2.80) and they had odds ratio for TAD of 1.87 (95% CI 1.09-3.20) after adjusting for sex, age, study center and hypertension. We did not find significant differences in aortic size, a potential confounder for TAD, between rs2118181 risk variant carriers and non-carriers: mean aortic size was 5.56 (95% CI: 5.37-5.73) for risk variant carriers (CC+CT) and was 5.48 (95% CI: 5.36-5.61) for noncarriers (TT) (p = 0.56). rs2118181 was not associated with TAA or TAAD. rs10519177 was not associated with TAD, TAA, or TAAD in the Yale study. Thus, the Yale study provided further support for the association of the FBN-1 rs2118181SNP with TAD.

Testing as a Service with HammerCloud

CERN Document Server

Medrano Llamas, Ramón; Elmsheuser, Johannes; Legger, Federica; Sciacca, Gianfranco; Sciabà, Andrea; van der Ster, Daniel

2014-01-01

HammerCloud was designed and born under the needs of the grid community to test the resources and automate operations from a user perspective. The recent developments in the IT space propose a shift to the software defined data centres, in which every layer of the infrastructure can be offered as a service. Testing and monitoring is an integral part of the development, validation and operations of big systems, like the grid. This area is not escaping the paradigm shift and we are starting to perceive as natural the Testing as a Service (TaaS) offerings, which allow testing any infrastructure service, such as the Infrastructure as a Service (IaaS) platforms being deployed in many grid sites, both from the functional and stressing perspectives. This work will review the recent developments in HammerCloud and its evolution to a TaaS conception, in particular its deployment on the Agile Infrastructure platform at CERN and the testing of many IaaS providers across Europe in the context of experiment requirements....

Assessing educational outcomes in middle childhood: validation of the Teacher Academic Attainment Scale.

Science.gov (United States)

Johnson, Samantha; Marlow, Neil; Wolke, Dieter

2012-06-01

Assessing educational outcomes in high-risk populations is crucial for defining long-term outcomes. As standardized tests are costly and time-consuming, we assessed the use of the Teacher Academic Attainment Scale (TAAS) as an outcome measure. Three hundred and forty three children in mainstream schools aged 10 to 11 years (144 males, 199 females; 190 extremely preterm and 153 term; mean age 10 y 9 mo, SD 5.5 mo, range 9 y 8 mo-12 y 3 mo) were assessed using the reading and mathematics scales of the criterion standard Wechsler Individual Achievement Test, 2nd (UK) edition (WIAT-II). Class teachers completed the TAAS, a seven-item questionnaire for assessing academic attainment. The TAAS was also completed at 6 years of age for 266 children. Cronbach's alpha 0.95 indicated excellent internal consistency, and the correlation between TAAS scores at 6 and 11 years indicated good test-retest reliability (r=0.77, pscale studies. © The Authors. Developmental Medicine & Child Neurology © 2012 Mac Keith Press.

Iirlaste uskumatu edu kivilinnas New Yorgis / Tambet Kaugema

Index Scriptorium Estoniae

Kaugema, Tambet

1998-01-01

Ameerika Ühendriikide rahvusliku raamatuauhinna laureaadid: Alice McDermott (ilukirjanduse auhind, romaan 'Charming Billy'), Edward Ball (aimekirjanduse auhind, 'Slaves in the family'), Gerald Stern (luuleauhind, 'This time'), Louis Sachar (noorsookirjanduse auhind), John Updike (elutöö auhind)

Galvex hädas pankrotti ihkava võlausaldajaga / Martin Hanson

Index Scriptorium Estoniae

Hanson, Martin, 1984-

2006-01-01

New Yorgi kohtusse antud pankrotikaitsehagi kohaselt on 2 miljardi krooni väärtuses tehtud pakkumine Galvexi varade ja kohustuste omastamiseks. Pakkumise taga arvatakse olevat Venemaa terasetootja Severstal. Vt. samas: Galvex jõudis täisvõimsuseni 4 aastaga; Silver Point Capital on tuntud vaenulike ülevõtmiste poolest

Muuseumid kaubamajadeks? / Maria-Kristiina Soomre

Index Scriptorium Estoniae

Soomre, Maria-Kristiina, 1978-

2001-01-01

Võib juhtuda, et Tate Gallery on sunnitud müüma teoseid oma kollektsioonist katmaks Tate Moderni loomisega kaasnenud kulusid. Sothebys tulevad 25. IV müügile 350 XX sajandi alguse Edward Steicheni, Walker Evansi, Alfred Stieglitzi, EugèneAtgeti, Man Ray fotot New Yorgi MOMA kogudest

Siim Nestor soovitab : Bell Orchestre. DJ Deep ja TRL. Akrobatik ja MC Mr.Lif. Black Dice / Siim Nestor

Index Scriptorium Estoniae

Nestor, Siim, 1974-

2008-01-01

Muusikaüritustest: Kanada post-rock ansambel Bell Orchestre12. sept. Tallinnas klubis Juuksur, DJ Deep 12. sept. Tallinna Linnahalli ruumides Plektrumi klubiööl (vt. www.plektrumfestival.ee), Akrobatik ja Mr.Lif 12. sept. Tartus klubis Illusion, New Yorgi kollektiiv Black Dice 17. sept. Tallinnas Von Krahlis

Aid should be 'value based' / Ella Karapetyan

Index Scriptorium Estoniae

Karapetyan, Ella

2010-01-01

New Yorgis Blouini fondi konverentsil esinenud Eesti välisminister Urmas Paet leidis, et tulemusliku arengukoostöö eeldused on korruptsiooni vähendamine ja heade valitsemistavade juurutamine arengukoostöö sihtriikides. Blouini sihtasutuse eesmärk on tõsta teadlikkust globaliseerumise väljakutsete ja võimaluste kohta

The right to just administrative action in the context of suspending ...

African Journals Online (AJOL)

For the decision to be taken in a lawful manner, the senior SARS official must at least be authorised to exercise the discretion in terms of the TAA and comply with the procedures and conditions stated in section 164(3) of the TAA. For the decision to be considered reasonable, the decision must be, at the minimum, rational ...

Improvement of Flow Characteristics for an Advanced Plasma Thruster

International Nuclear Information System (INIS)

Inutake, M.; Hosokawa, Y.; Sato, R.; Ando, A.; Tobari, H.; Hattori, K.

2005-01-01

A higher specific impulse and a larger thrust are required for a manned interplanetary space thruster. Until the realization of a fusion-plasma thruster, a magneto-plasma-dynamic arcjet (MPDA) powered by a fission reactor is one of the promising candidates for a manned Mars space thruster. The MPDA plasma is accelerated axially by a self-induced j x B force. Thrust performance of the MPDA is expected to increase by applying a magnetic nozzle instead of a solid nozzle. In order to get a much higher thruster performance, two methods have been investigated in the HITOP device, Tohoku University. One is to use a magnetic Laval nozzle in the vicinity of the MPDA muzzle for converting the high ion thermal energy to the axial flow energy. The other is to heat ions by use of an ICRF antenna in the divergent magnetic nozzle. It is found that by use of a small-sized Laval-type magnetic nozzle, the subsonic flow near the muzzle is converted to be supersonic through the magnetic Laval nozzle. A fast-flowing plasma is successfully heated by use of an ICRF antenna in the magnetic beach configuration

Reduction in Wound Complications After Total Ankle Arthroplasty Using a Compression Wrap Protocol.

Science.gov (United States)

Schipper, Oliver N; Hsu, Andrew R; Haddad, Steven L

2015-12-01

The purpose of this study was to evaluate the clinical differences in wound complications after total ankle arthroplasty (TAA) between a cohort of patients that received a compression wrap protocol and a historical control group treated with cast immobilization. Patient charts and postoperative wound pictures were reviewed for 42 patients who underwent a compression wrap protocol and 50 patients who underwent circumferential casting after primary TAA from 2008 to 2013. A blinded reviewer graded each wound using a novel postoperative wound classification system, and recorded whether the wound was completely healed by or after 3 months. A second blinded review was performed to determine intraobserver reliability. Mean patient age was 55 years (range, 24-80) and all patients had at least 6-month follow-up. There were significantly more total wound complications (P = .02) and mild wound complications (P = .02) in the casted group compared to the compression wrap group. There were no significant differences in the number of moderate and severe complications between each group. A significantly higher proportion of TAA incisions took longer than 3 months to heal in the casted group (P = .02). Based on our clinical experience with postoperative wound care after TAA, use of a compression wrap protocol was safe and effective at reducing wound-related complications, and well tolerated by patients. Further prospective, randomized clinical trials are warranted to evaluate the utility and cost-effectiveness of a compression wrap protocol after TAA. © The Author(s) 2015.

Classification of 27 Tumor-Associated Antigens by Histochemical Analysis of 36 Freshly Resected Lung Cancer Tissues

Directory of Open Access Journals (Sweden)

Gene Kurosawa

2016-11-01

Full Text Available In previous studies, we identified 29 tumor-associated antigens (TAAs and isolated 488 human monoclonal antibodies (mAbs that specifically bind to one of the 29 TAAs. In the present study, we performed histochemical analysis of 36 freshly resected lung cancer tissues by using 60 mAbs against 27 TAAs. Comparison of the staining patterns of tumor cells, bronchial epithelial cells, and normal pulmonary alveolus cells and interalveolar septum allowed us to determine the type and location of cells that express target molecules, as well as the degree of expression. The patterns were classified into 7 categories. While multiple Abs were used against certain TAAs, the differences observed among them should be derived from differences in the binding activity and/or the epitope. Thus, such data indicate the versatility of respective clones as anti-cancer drugs. Although the information obtained was limited to the lung and bronchial tube, bronchial epithelial cells represent normal growing cells, and therefore, the data are informative. The results indicate that 9 of the 27 TAAs are suitable targets for therapeutic Abs. These 9 Ags include EGFR, HER2, TfR, and integrin α6β4. Based on our findings, a pharmaceutical company has started to develop anti-cancer drugs by using Abs to TfR and integrin α6β4. HGFR, PTP-LAR, CD147, CDCP1, and integrin αvβ3 are also appropriate targets for therapeutic purposes.

Praost Thomas Vaga 70 / Juhan Simonson ; foto: Juhan Simonson

Index Scriptorium Estoniae

Simonson, Juhan, 1933-2012

2008-01-01

8. märtsil 70 aastaseks saavast üle 20 aasta kirikuõpetajana New Jerseys ja New Yorgis teeninud praost Thomas Vagast. President Toomas Hendrik Ilves annetas iseseisvuspäeva puhul Thomas Vagale kui eestluse hoidjale Ameerika Ühendriikides ja kirikuelu edendajale Valgetähe IV klassi teenetemärgi

Emad kinolinal / Maria Ulfsak-Sheripova

Index Scriptorium Estoniae

Ulfsak-Šeripova, Maria, 1981-

2007-01-01

Filmid : Roger Mitchelli "Ema", Douglas Sirki "Kõik, mida taevas lubab", Rainer Werner Fassbinderi "Hirm närib hinge seest", Todd Haynesi "On taevas nii kaugel", Alfred Hitchcocki "Psühho", Woody Alleni "New Yorgi lood", Lars von Trieri "Idioodid", "Alieni" filmid, Pedro Almodovari "Kõik minu emast" ja Catherine Breillat' "Romanss"

Ooper tuleb kinosaali / Christel Karits

Index Scriptorium Estoniae

Karits, Christel, 1966-

2008-01-01

Forum Cinemas toob oktoobrist maini Tallinnas Coca-Cola Plazas ja Tartus Ekraanis publikuni New Yorgi Metropolitan Opera etenduste HD-otseülekanded: Richard Straussi "Salome" (peaosas Karitta Mattila), "Orfeus ja Eurydike", "Lucia di Lammermoor", "Madame Butterfly", "La Sonnambula" ja "Tuhkatriinu", etenduste vaheajal näeb vaataja intervjuusid ooperitähtedega

Meeli Kõiva vitraažid ajakirja Stained Glass talvenumbris / Rein Eriksson

Index Scriptorium Estoniae

Eriksson, Rein

1998-01-01

Intervjuust Meeli Kõivaga Ameerika Ühendriikide vitraažikunstnike Assotsiatsiooni ajakirja "Stained Glass" talvenumbris. Avaldati 8 fotot kunstniku vitraažidest. Artikli "Unistused transparentsest ruumist" autor - USA vitraažikunstnike Assotsiatsiooni endine president Helene Weiss. M. Kõiva esines aprillis 1997 akvarellidega grupinäitusel New Yorgis, Broadway galeriis Art 54.

Intiimsed pilgud (taas)avastatud ruumile

Index Scriptorium Estoniae

1998-01-01

Eesti ja inglise kunstnike feministlik ühisprojekt "Private Views" 1. juunist Rotermanni soolalaos. Kuraatorid Mare Tralla, Pam Skelton. Näituse eesmärk - jälgida ruumikogemuse vahendamist eesti ja inglise kunstis. Keskmes naise koht ja suhe ruumiga 90ndate Euroopas. Kasutatud fotot, videot, arvutikunsti. Osalejad toodud - Eestist Anu Juurak, Eve Kiiler, Mari Koort, Ene-Liis Semper, Kiwa, Liina Siib, Annika Tonts, F.F.F.F., Mare Tralla

Tarbekunsti- ja Disainimuuseum taas avatud

Index Scriptorium Estoniae

2005-01-01

2. VI avati rekonstrueeritud muuseumihoone. Rekonstrueerimisprojekti autorid: Arhitektuuriagentuuri arhitekt Inga Raukas, sisearhitekt Monika Löve. Ehitustööd: Rihti Projekt. Avatud nahakunstinäitus "Järjehoidja" (kuraator Airi Ligi, kujundaja Siiri Nõva, näha saab ka nahakunsti üliõpilaste töid; filmiprogramm: Maya Yonesho "Üks uks", "Ecce libri" Pille Kivihallist, Tiina Piisangust ja Maarja Unduskist) ja rahvusvaheline köitekunstinäitus "Scripta manent III. Maailma parim asi", kujundaja Lennart Mänd

Pärnus taas kuldne svingiajastu

Index Scriptorium Estoniae

2008-01-01

19. ja 26. dets. esinevad Pärnus Café Grandis Pärnu linnaorkestri muusikutest koosnev bigbänd Swingkompanii G7 ja Airi Allvee, kõlavad Glenn Milleri, Duke Ellingtoni, RAimond Valgre jt lood (arranzheeringud on Olev Söödilt)

Pärnu filmifestival taas ETVs

Index Scriptorium Estoniae

2007-01-01

XXI Rahvusvaheline Pärnu filmifestival : Eesti Televisioon näitab 8.-14.07. eriprogrammi, kuhu on valitud filmid "Minu surm, mitte sinu" (Saksamaa-India 2006), "Valgevene õppetund" (Poola-Valgevene 2006), "Beslan - õigus elada" (Venemaa 2006), "Esimene rahu õppetund" (Iisrael 2006), "Õnne vaenlased" (Taani-Afganistan 2006), "Mu tütar on terrorist" (Norra 2006) ja "Lugu kehast" (Iisrael 2006)

Christo kuldab Manhattani vaateid / Johannes Saar

Index Scriptorium Estoniae

Saar, Johannes, 1965-

2005-01-01

Gabrovost pärit prantsuse-ameerika kunstniku Christo (Christo Vladimirov Javacheff) ja tema kaasa Jeanne-Claude'i (Jeanne-Claude de Guillebon) projekt "Väravad" New Yorgi Central Park'is. Kunstnikepaaril on kavas palistada kõik pargirajad viie meetri kõrguste väravaraamistikega, millel ripuvad kirkad oranzhid kangad. Toimumisaeg 12.-27. veebruar 2005

Patsifist Aki : Karismjaki napleval na "Oskar"

Index Scriptorium Estoniae

2003-01-01

Aki Kaurismäki keeldus sõitmast Los Angelesse Oscari galale protestiks Iraagi sõja vastu, nagu ta eelmisel aastal ei sõitnud New Yorgi rahvusvahelisele filmifestivalile oma filmiga "Minevikuta mees", kuna iraani mainekas režissöör Abbas Kiarostami ei saanud sissesõiduviisat. Ka Oscari galal sõjavastaselt esinenud auhinnasaajatest

Fine 5 kolib Kumu lavale

Index Scriptorium Estoniae

2006-01-01

Kumu kunstimuuseumi auditooriumis toimub 21. veebruaril Fine 5 kaasaegse tantsu etendus "Panus". Esinevad Tiina Ollesk, Irina Pähn, žonglöör Dimitri Kruus, disainer Rain Saukas ja muusik Mattias Siitan

Tants valguse laval / Aili Ermel

Index Scriptorium Estoniae

Ermel, Aili

2013-01-01

Valgustid Milanos toimunud messil "Euroluce 2013". Mihkel Masso ja Johan Tali paberlennukitest inspireeritud laevalgustid "Hetk". Tarmo Luisu valgusti "Spider" ja valgustisari "Toila", Tõnis Vellama valgusti "Aero", Tõnis Vellama ja Kalju Palo seinavalgusti "Retro", Triin Kõivupuu ja Eva Prüüsi valgustisari "Lill"

Ameliorative effects of rutin on hepatic encephalopathy-induced by thioacetamide or gamma irradiation.

Science.gov (United States)

Mansour, Somaya Z; El-Marakby, Seham M; Moawed, Fatma S M

2017-07-01

Hepatic encephalopathy (HE) is a syndrome resulting from acute or chronic liver failure. This study was designed to evaluate the effect of rutin on thioacetamide (TAA) or γ-radiation-induced HE model. Animals were received with TAA (200mg/kg, i.p.) twice weekly for four weeks or exposed to 6Gy of γ-radiation to induce HE then groups orally treated with rutin (50mg/kg b.wt.) for four weeks. At the end of experiment, blood, liver and brain samples were collected to assess biochemical and biophysical markers as well histopathological investigations. TAA or γ-radiation exposed rats experienced increases in serum activities of ALT, AST, ALP and ammonia level. Also an alteration in relative permeability and conductivity of erythrocytes was observed. Furthermore, cytokines levels and AChE activity were induced whereas the activities of HO-1 and neurotransmitters contents were depleted. TAA or γ-radiation caused distortion of hepatic and brain architecture as shown by histopathological examination. Treatment with rutin resulted in improvement in liver function by the decline in serum AST and ALT activities and reduction in serum ammonia level. In addition, the administration of rutin significantly modulated the alteration in cytokines levels and neurotransmitters content. Histopathological examinations of liver and brain tissues showed that administration of rutin has attenuate TAA or radiation-induced damage and improve tissue architecture. Consequently, rutin has been a powerful hepatoprotective effect to combat hepatic encephalopathy associated hyperammonemia and its consequential damage in liver and brain. Copyright © 2017 Elsevier B.V. All rights reserved.

Nocturnal thoracoabdominal asynchrony in house dust mite-sensitive nonhuman primates

Directory of Open Access Journals (Sweden)

XiaoJia Wang

2010-07-01

Full Text Available XiaoJia Wang, Shaun Reece, Stephen Olmstead, Robert L Wardle, Michael R Van ScottDepartment of Physiology, East Carolina University, Greenville, North Carolina, USAAbstract: Nocturnal bronchoconstriction is a common symptom of asthma in humans, but is poorly documented in animal models. Thoracoabdominal asynchrony (TAA is a noninvasive clinical indication of airway obstruction. In this study, respiratory inductive plethysmography (RIP was used to document nocturnal TAA in house dust mite (HDM-sensitive Cynomolgus macaques. Dynamic compliance (Cdyn and lung resistance (RL measured in anesthetized ­animals at rest and following exposure to HDM allergen, methacholine, and albuterol were highly ­correlated with three RIP parameters associated with TAA, ie, phase angle of the rib cage and abdomen waveforms (PhAng, baseline effort phase relation (eBPRL and effort phase relation (ePhRL. Twenty-one allergic subjects were challenged with HDM early in the morning, and eBPRL and ePhRL were monitored for 20 hours after provocation. Fifteen of the allergic subjects exhibited gradual increases in eBPRL and ePhRL between midnight and 6 am, with peak activity at 4 am. However, as in humans, this nocturnal response was highly variable both between subjects and within subjects over time. The results document that TAA in this nonhuman primate model of asthma is highly correlated with Cdyn and RL, and demonstrate that animals exhibiting acute responses to allergen exposure during the day also exhibit nocturnal TAA.Keywords: nocturnal asthma, late phase asthmatic response, respiratory inductive plethysmography

Fibrinolytic activity is associated with presence of cystic media degeneration in aneurysms of the ascending aorta

OpenAIRE

Borges , Luciano F; Gomez , Delphine; Quintana , Mercedes; Leclercq , Anne; Touat , Ziad; Jondeau , Guillaume; Meilhac , Olivier; Jandrot-Perrus , Martine; Gutierrez , Paulo Sampaio; Freymuller , Edna; Vranckx , Roger; Michel , Jean-Baptiste

2010-01-01

Abstract Aims Thoracic Ascending Aortic Aneurysms (TAA) are characterized by elastic fibre breakdown and cystic medial degeneration within the aortic media, associated with progressive SMC rarefaction. The TGF-?/Smad2 signaling pathway is involved in this process. Since pericellular fibrinolytic system activation is able to degrade adhesive proteins, activate MMPs, induce SMC disappearance and increase the bio-availability of TGF-?, we explored the plasminergic system in TAA. ...

Poika on suruissansa (2/4 F)

OpenAIRE

2011-01-01

Laulun sanat: Poika on suruissansa, kun on jäänyt kullastansa; kiertää piirin ympäri ja ottaa uuden taas, kiertää piirin ympäri ja ottaa uuden taas! Hih-hei, ja pili-pam-pam-pam, pili-pam-pam-pam, pili-pam-pam-pam! Hih-hei, ja pili-pam-pam-pam! Kiertää piirin ympäri ja

Early Primary Care Provider Follow-up and Readmission After High-Risk Surgery

Science.gov (United States)

Brooke, Benjamin S.; Stone, David H.; Cronenwett, Jack L.; Nolan, Brian; DeMartino, Randall R.; MacKenzie, Todd A.; Goodman, David C.; Goodney, Philip P.

2014-01-01

IMPORTANCE Follow-up with a primary care provider (PCP) in addition to the surgical team is routinely recommended to patients discharged after major surgery despite no clear evidence that it improves outcomes. OBJECTIVE To test whether PCP follow-up is associated with lower 30-day readmission rates after open thoracic aortic aneurysm (TAA) repair and ventral hernia repair (VHR), surgical procedures known to have a high and low risk of readmission, respectively. DESIGN, SETTING, AND PARTICIPANTS In a cohort of Medicare beneficiaries discharged to home after open TAA repair (n = 12 679) and VHR (n = 52 807) between 2003 to 2010, we compared 30-day readmission rates between patients seen and not seen by a PCP within 30 days of discharge and across tertiles of regional primary care use. We stratified our analysis by the presence of complications during the surgical (index) admission. MAIN OUTCOMES AND MEASURES Thirty-day readmission rate. RESULTS Overall, 2619 patients (20.6%) undergoing open TAA repair and 4927 patients (9.3%) undergoing VHR were readmitted within 30 days after surgery. Complications occurred in 4649 patients (36.6%) undergoing open TAA repair and 4528 patients (8.6%) undergoing VHR during their surgical admission. Early follow-up with a PCP significantly reduced the risk of readmission among open TAA patients who experienced perioperative complications, from 35.0% (without follow-up) to 20.4% (with follow-up) (P < .001). However, PCP follow-up made no significant difference in patients whose hospital course was uncomplicated (19.4% with follow-up vs 21.9% without follow-up; P = .31). In comparison, early follow-up with a PCP after VHR did not reduce the risk of readmission, regardless of complications. In adjusted regional analyses, undergoing open TAA repair in regions with high compared with low primary care use was associated with an 18% lower likelihood of 30-day readmission (odds ratio, 0.82; 95% CI, 0.71–0.96; P = .02), whereas no significant

LHV pankureid vanglakaristus esialgu ei ähvarda / Aleksei Günter, Aivar Reinap

Index Scriptorium Estoniae

Günter, Aleksei, 1979-

2005-01-01

Ilmunud ka: Postimees : na russkom jazõke 8. nov., lk 10. New Yorgis algavast kohtuprotsessist, milles USA väärtpaberituru järelvalve (SEC) süüdistab Eesti investeerimispanga LHV töötajaid Oliver Peeki ja Kristjan Lepikut ning LHV-d börsiettevõtte siseinfo varguses pressiteateid avaldavast portaalist Business Wire

Tere tulemast hetkesituatsiooni : märkmed olemisest kunstiteosena = Welcome to this situatsion : notes on being an artwork / David Rothenberg

Index Scriptorium Estoniae

Rothenberg, David

2008-01-01

Saksamaal elava rootsi-india päritolu kunstniku Tino Sehgali (1976) näitusest "This situation" New Yorgis 2007. aasta lõpul - näitus oli situatsioon, kuhu kolmkümmend palutud osavõtjat-vestlejat andsid oma panuse. Näitust ei jäädvustata, see peaks säilima mälus ja tundeelus

Muusikamaailm : "Väike Bayreuth" Berliinis. Metropolitan Opera hooaeg lõppemas. "Millenniumi" teosed Londonis. Viini Filharmoonikute kolmas auliige. Leiti Beethoveni kiri / Priit Kuusk

Index Scriptorium Estoniae

Kuusk, Priit, 1938-

1999-01-01

Dirigendi algatatud festivalist Berliinis, kus pannakse pearõhk Wagneri ooperite ettekandele. New Yorgi Metropolitan Opera kevadhooaja 1999 viimastest etendustest. Londonis Royal Festival Hallis toimus R.Caustoni teose "Millennium Scenes" maailmaesiettekanne. J.Taveneri teosest "Fall and resurrection". Orkester valis oma kolmandaks auliikmeks A.Brendeli. Baseli ülikool sai enda valdusse Beethoveni kirja Nikolaus Zmeskallile 1816. aastast

Popnädal. Inglise TOP 20 albumid

Index Scriptorium Estoniae

2002-01-01

Hiphopar P. Diddy 33. sünnipäeva tähistamisest. Ansamblist Radiohead. Madonna osalemisest USAs telereklaamis. Ansambli Foo Fightersi juhtfiguurist Dave Grohlist. N*E*R*D-i (The Neptunesi lavanimi) debüütalbumi "In Search of..." pärjamisest auhinnaga "Shortlist Prize". Ansamblist Metallica. Britney Spearsi New Yorgis asunud restorani "Nyla" sulgemisest

Effect of different sulphur precursors on morphology and band-gap on the formation of Cu{sub 2}ZnSnS{sub 4} (CZTS) particles with microwave irradiation

Energy Technology Data Exchange (ETDEWEB)

Patro, Bharati; Vijaylakshmi, S., E-mail: vlakshmi@iitb.ac.in [Centre for Research in Nanotechnology and Sciences, Indian Institute of Technology Bombay (India); Sharma, Pratibha [Department of Energy Sciences and Engineering, Indian Institute of Technology Bombay (India)

2016-05-23

Cu{sub 2}ZnSnS{sub 4} (CZTS) is a promising semiconductor material for ecological cost effective thin film Photovoltaic (PV) devices. As it contains earth abundant and non-toxic elements, it has the advantages over commercially available CIGS and CdTe thin film PV devices. In the present work, the pure phase Cu{sub 2}ZnSnS{sub 4} particles were successfully synthesised with microwave irradiation. The morphology and phase study was carried out for the samples prepared with two different sulphur precursors viz. thiourea and thioacetamide (TAA). CZTS particles with thiourea as sulphur precursor are more crystalline than CZTS particles with TAA. The band gap of 1.654 eV and 1.713 eV were calculated for the samples prepared with thiourea and TAA respectively.

Näitlejad ühes mullis, esietendus ukse ees / Hendrik Toompere jr. jr., Liisa Pulk, Mait Joorits ... [jt.] ; intervjueerinud Liisi Seil ; kommenteerinud Helle Leppik

Index Scriptorium Estoniae

2010-01-01

Vestlus Eesti muusika- ja teatriakadeemia lavakunstikooli XXIV lennu tudengitega, kelle lõputöö Tom Stoppardi näidend "Arkaadia" etendub Ugala laval. Lisatud Ugala teatri kirjandustoimetaja arvamus

Training for my Life: Lived Experiences of Dislocated Workers in an Advanced Manufacturing Training Program

OpenAIRE

Marquita R. Walker

2012-01-01

This qualitative paper explores the lived experiences of one group of workers dislocated because of globalized trade policies who completed a hybrid Advanced Manufacturing Training Program (AMTP) by taking advantage of Trade Adjustment Assistance (TAA), a federally-funded program for retraining workers dislocated because of trade policies. The research questions focus on how satisfied these workers are with the services and programs provided by TAA. Focus groups and survey instrument results ...

The partial mitochondrial sequence of the Old World stingless bee ...

Indian Academy of Sciences (India)

Sequences of primers used in PCR reactions of T. pagdeni mtDNA. mtDNA genes. Primer. Sequence. ATPase (6,8). ATPS6-F. 5 -AAG ATA TAT GGA AAT AAG CT-3. tRNA-ASP-R. 5 -ATA AAA TAA CGT CAA AAT GTC A-3. COI. COI-F. 5 - ATA ATT ATT GTT GCT GAT GTA-3. COI-R. 5 -CTA TTC ATA TAA CTG GAA TTT C-3.

Julia Scher / Julia Scher ; interv. Tilman Baumgärtel

Index Scriptorium Estoniae

Scher, Julia

2006-01-01

Ameerika installatsiooni- ja tegevuskunstnikust Julia Scher'ist (sünd. 1954) ja tema loomingust, telefonivestlus kunstnikuga 15. II 2001. Installatsioonidest, milles kunstnik kasutas järelevalvesüsteemide võrgustikke, virtualsest SM-klubist elektroonilisel teadetetahvlil The Thing, New Yorgis baseeruva võrgugalerii "Adaweb" jaoks valminud võrguprojektidest "Konsent Klinik (1997) ja "Security Land" (1995) ning muust

President Rüütel's speech at UN / Arnold Rüütel

Index Scriptorium Estoniae

Rüütel, Arnold

2004-01-01

President Arnold Rüütli 22. septembril New Yorgis ÜRO peaassamblee 59. istungjärgu peadebatil peetud kõne, milles ta keskendus ÜRO aastatuhande deklaratsioonis sõnastatud eesmärkide täitmise ja digitaalse lõhe ületamise võimalustele ning põlisrahvaste õiguste kaitsele. Töövisiit New Yorki 19.-24.09.2004

Kaks Flavinit korraga / Jaan Elken

Index Scriptorium Estoniae

Elken, Jaan, 1954-

1998-01-01

Ameerika kunstniku Dan Flavini (1933-1996) loomingust seoses kunstniku neoon-torudest valgusskulptuuride näitusega New Yorgi Leo Castelli galeriis märtsis ja 542 West 22. Tänaval asuvas DIA kunstikeskuses eksponeeritava suure Flavini retrospektiiviga, mis esitleb töid aastaist 1961-1996, avatud 14. juunini. Flavini tsitaat oma ikoonidest aastast 1962. DIA kunstikeskusest (direktor Michael Govan).

Alma mater NYC : võimenda, kiirenda, kuhja / Mariliis Lilover

Index Scriptorium Estoniae

Lilover, Mariliis

2014-01-01

Mariliis Liloveri arhitektuurialastest õpingutest New Yorgis (Graduate School of Architecture, Planning and Preservation at Columbia University) ja tema arvamusest, et koolide ülesandeks on koolitada selline arhitekt, kelle eesmärk peaks olema ületada nii iseennast kui ka tellija unistusi, kavandades midagi, mida klient algul ei osanud soovida, kuid usub lõpuks, et just sellisest tulemusest ta unistaski

Muusikauudiseid maailmast / Nele-Eva Steinfeld

Index Scriptorium Estoniae

Steinfeld, Nele-Eva

2016-01-01

Lühisõnumeid maailmast: Leonidas Kavakos pälvis 2017. aasta Léonie Sonningi preemia. Siemensi preemia laureaadiks on Per Nørgård. New Yorgi Filharmoonikute uueks juhiks saab Jaap van Zweden. Wigmore Hall avas voogedastusteenuse. Mirga Gražinytê-Tyla Birminghamis. Ligi 88 miljoni rubla eest pääsmeid ühe päevaga

Arhitektuurimuuseumid ehitavad / Karin Hallas

Index Scriptorium Estoniae

Hallas, Karin, 1957-

2001-01-01

Arhitektuurimuuseumide konföderatsiooni (ICAM) juhatuse aastakoosolekust Los Angeleses. Uusi ruume saanud või saavaid arhitektuurikeskusi. Uue muuseumikompleksi ehitamist on alustanud New Yorgi Moodsa Kunsti Muuseum (arhitekt Yoshio Taniguchi), 2002. a. valmib Münchenis Moderne Pinakothek (Stephan Braunfels), 2003. a. saab uued ruumid Berlinische Galerie (Frederik Fisher), uue maja Norra Arhitektuurimuuseum (Sverre Fehn), Arhitektuuri- ja Disainimuuseumi konkurss Soomes.

Bush müüks Ameerika sadamad araablastele / Neeme Raud

Index Scriptorium Estoniae

Raud, Neeme, 1969-

2006-01-01

Ilmunud ka: Postimees : na russkom jazõke 23. veebr. lk. 11. USA presidendi George W. Bushi plaani kohaselt ostaks New Yorgi, New Jersey, Philadelphia, Baltimore'i, Miami ja New Orleansi sadamad Dubai firma Peninsular and Oriental Steam Navigation Company. Mitmed USA poliitikud leiavad, et sadamate müük seab ohtu USA julgeoleku. Lisa: Välisfirmade võim

Graafikatriennaalist kunstitriennaaliks / Harry Liivrand

Index Scriptorium Estoniae

Liivrand, Harry, 1961-

2004-01-01

Tallinna XIII graafikatriennaalist. Peateemaks maapagu ja eksiilisolek. Eksiiliteemat kommenteerivad David Kiehl (New Yorgi Whitney muuseumi kuraator), Maaretta Jaukkuri (Helsingi Kiasma muuseumi kuraator), Irina Cios (Bukaresti kunstiteadlane), Silvina Der-Meguerditchian (argentiina kunstnik). Parimaks väljapanekuks Sirje Helme kuraatorinäitus "Teine naaber" Tallinna Kunstihoones ja Kunstihoone galeriis. Marko Mäetamme ja Kaido Ole 100 betoonkohvri projektist. Triennaali preemiasaajad

Klimti tööd tagasi saanud juudi pere müüb need maha

Index Scriptorium Estoniae

2006-01-01

Klimti maalide "Kasemets/Pöögimets" (1901), "Adele Bloch-Bauer II" (1912), "Õunapuu" (1912) ja "Majad Unterachis Attersee ääres" (1916) õiguspäraseks omanikuks tunnistati Ferdinand Bloch-Baueri vennatütar Maria Altmann. Maalid müüakse sügisel. Praegu asuvad maalid New Yorgis saksa ja austria kunsti muuseumis Neue Galerie's

Getter Jaani osaleb nukuteatri muusikalis / Karilin Engelbrecht

Index Scriptorium Estoniae

Engelbrecht, Karilin

2009-01-01

2010. aasta kevadel jõuab nukuteatri lavale Walt Disney menufilmi "High School Musical" samanimeline muusikal kohalike lauljate esituses. Tüdrukutest peetakse suurimaks favoriidiks Getter Jaanit. Muusikali lavastab Andres Dvinjaninov

Muusikamaailm / Priit Kuusk

Index Scriptorium Estoniae

Kuusk, Priit, 1938-

1999-01-01

La Scalaga ei olda enam rahul, Dresdenis tuli lavale Richard Straussi ooper "Ariadne Naxoselt", uus orkestriteos John Adamsilt, Müncheni muusikabiennaali uudiseid, suri üks rahvusvahelise kooriliikumise silmapaistvamaid tegelasi

Melatonin mitigates thioacetamide-induced hepatic fibrosis via antioxidant activity and modulation of proinflammatory cytokines and fibrogenic genes.

Science.gov (United States)

Lebda, Mohamed A; Sadek, Kadry M; Abouzed, Tarek K; Tohamy, Hossam G; El-Sayed, Yasser S

2018-01-01

The potential antifibrotic effects of melatonin against induced hepatic fibrosis were explored. Rats were allocated into four groups: placebo; thioacetamide (TAA) (200mg/kg bwt, i.p twice weekly for two months); melatonin (5mg/kgbwt, i.p daily for a week before TAA and continued for an additional two months); and melatonin plus TAA. Hepatic fibrotic changes were evaluated biochemically and histopathologically. Hepatic oxidative/antioxidative indices were assessed. The expression of hepatic proinflammatory cytokines (tumor necrosis factor-α, and interleukin-1β), fibrogenic-related genes (transforming growth factor-1β, collagen I, collagen, III, laminin, and autotaxin) and an antioxidant-related gene (thioredoxin-1) were detected by qRT-PCR. In fibrotic rats, melatonin lowered serum aspartate aminotransferase, alanine aminotransferase, and autotaxin activities, bilirubin, hepatic hydroxyproline and plasma ammonia levels. Melatonin displayed hepatoprotective and antifibrotic potential as indicated by mild hydropic degeneration of some hepatocytes and mild fibroplasia. In addition, TAA induced the depletion of glutathione, glutathione s-transferase, glutathione peroxidase, superoxide dismutase, catalase, and paraoxonase-1 (PON-1), while inducing the accumulation of malondialdehyde, protein carbonyl (C=O) and nitric oxide (NO), and DNA fragmentation. These effects were restored by melatonin pretreatment. Furthermore, melatonin markedly attenuated the expression of proinflammatory cytokines and fibrogenic genes via the upregulation of thioredoxin-1 mRNA transcripts. Melatonin exhibits potent anti-inflammatory, antioxidant and fibrosuppressive activities against TAA-induced hepatic fibrogenesis via the suppression of oxidative stress, DNA damage, proinflammatory cytokines and fibrogenic gene transcripts. In addition, we demonstrate that the antifibrotic activity of melatonin is mediated by the induction of thioredoxin-1 with attenuation of autotaxin expressions

Structural Basis for Toughness and Flexibility in the C-terminal Passenger Domain of an Acinetobacter Trimeric Autotransporter Adhesin*

Science.gov (United States)

Koiwai, Kotaro; Hartmann, Marcus D.; Linke, Dirk; Lupas, Andrei N.; Hori, Katsutoshi

2016-01-01

Trimeric autotransporter adhesins (TAAs) on the cell surface of Gram-negative pathogens mediate bacterial adhesion to host cells and extracellular matrix proteins. However, AtaA, a TAA in the nonpathogenic Acinetobacter sp. strain Tol 5, shows nonspecific high adhesiveness to abiotic material surfaces as well as to biotic surfaces. It consists of a passenger domain secreted by the C-terminal transmembrane anchor domain (TM), and the passenger domain contains an N-terminal head, N-terminal stalk, C-terminal head (Chead), and C-terminal stalk (Cstalk). The Chead-Cstalk-TM fragment, which is conserved in many Acinetobacter TAAs, has by itself the head-stalk-anchor architecture of a complete TAA. Here, we show the crystal structure of the Chead-Cstalk fragment, AtaA_C-terminal passenger domain (CPSD), providing the first view of several conserved TAA domains. The YadA-like head (Ylhead) of the fragment is capped by a unique structure (headCap), composed of three β-hairpins and a connector motif; it also contains a head insert motif (HIM1) before its last inner β-strand. The headCap, Ylhead, and HIM1 integrally form a stable Chead structure. Some of the major domains of the CPSD fragment are inherently flexible and provide bending sites for the fiber between segments whose toughness is ensured by topological chain exchange and hydrophobic core formation inside the trimer. Thus, although adherence assays using in-frame deletion mutants revealed that the characteristic adhesive sites of AtaA reside in its N-terminal part, the flexibility and toughness of the CPSD part provide the resilience that enables the adhesive properties of the full-length fiber across a wide range of conditions. PMID:26698633

Kaebus sunnib teatreid suitsetamise osas aru pidama

Index Scriptorium Estoniae

2009-01-01

Draamateatri külastaja kaebuse peale - etenduses "Pedro Páramo" suitsetas näitleja Mait Malmsten kogu esimese vaatuse - arutab Eesti Etendusasutuste Liit peagi laval suitsetamisega seotud küsimusi

Leto v Russkom teatre

Index Scriptorium Estoniae

2007-01-01

Augustis Vene Teatri alternatiivsel laval "Garaaž" : 9. augustil "Veerevad kivid ei sammaldu", lavastaja Nikita Grinshpun (Moskva) ja 7., 8. augustil Aleksandr Potuzhnõi lavastus "Jõgi asfaldil", autor Dmitri Lipskerov

"Pähklipureja" Uzide ja gaasimaskidega

Index Scriptorium Estoniae

2002-01-01

Inglise rahvusballetis tuli lavale Pjotr Tsaikovski balleti "Pähklipureja" radikaalne versioon, kostüümide autor on karikaturist Gerald Scarfe, koreograaf Christopher Hampson, tantsivad ka Toomas Edur ja Age Oks

Austusavaldus Puccinile / Silja Joon

Index Scriptorium Estoniae

Joon, Silja, 1966-

2008-01-01

Puccini galakontserdist Pärnu rahvusvahelise ooperimuusika festivali PromFest raames 15. mail Endla teatris ja 16. mail Tallinnas Vene teatris (laval rahvusvahelise Klaudia Taevi konkursi võitjad läbi aegade)

Noored tähed Puccinile pühendatud galaõhtul Endlas / Toomas Kuter

Index Scriptorium Estoniae

Kuter, Toomas, 1965-

2008-01-01

Puccini galakontserdist Pärnu rahvusvahelise ooperimuusika festivali PromFest raames 15. mail Endla teatris ja 16. mail Tallinnas Vene teatris (laval rahvusvahelise Klaudia Taevi konkursi võitjad läbi aegade)

Facilitating Social Collaboration in Mobile Cloud-Based Learning: A Teamwork as A Service (TaaS) Approach

Science.gov (United States)

Sun, Geng; Shen, Jun

2014-01-01

Mobile learning is an emerging trend that brings many advantages to distributed learners, enabling them to achieve collaborative learning, in which the virtual teams are usually built to engage multiple learners working together towards the same pedagogical goals in online courses. However, the socio-technical mechanisms to enhance teamwork…

Südames on armastuse kodu / Lembit Peterson, Marius Peterson

Index Scriptorium Estoniae

Peterson, Lembit, 1953-

2006-01-01

Theatrumis tuleb lavale Karol Wojtyla (Paavst Johannes Paulus II) kirjutatud näidend "Juveliiri poe ees". Lavastuses osaleb pea kogu perekond Petersonid. Laura, Marius, Mare, Maria ja Lembit Peterson endast ja peresidemetest

Pushkin na stsene / Boris Tuch

Index Scriptorium Estoniae

Tuch, Boris, 1946-

1999-01-01

A. Pushkini teosed eesti laval : "Padaemand" Vene Draamateatris, lavastaja Jevgeni Gaitshuk; "Jevgeni Onegin" Salong Teatris, lavastaja Erki Aule; "Väikesed trgöödiad" Theatrumis, lavastaja Lembit Peterson. Ka vestlusest Lembit Petersoniga

Ülle Kaljuste : Ma kartsin töötuks jääda / Jaanus Kulli

Index Scriptorium Estoniae

Kulli, Jaanus, 1955-

2005-01-01

25., 26. ja 27. veebruaril etendub Draamateatris J. Haydni lustlik õukonnaooper "Elu kuu peal" ("Il Mondo Della Luna"), mille seadsid lavale Andrus Vaarik, tema assistent Ülle Kaljuste ning dirigent Tõnu Kaljuste

Fine 5 tantsib Bachi järgi

Index Scriptorium Estoniae

2016-01-01

Tantsuteater Fine 5 toob lavale lavastuse "HTK ehk hästi treenitud klaviir". Teos on loodud J.S. Bachi "Hästitempereeritud klaviiri" (HTK) esimese osa muusikale. Koreograafid Tiina Ollesk ja Renee Nõmmik

WAF Dance etendab "Väikest printsi" / Karin Klaus

Index Scriptorium Estoniae

Klaus, Karin

2006-01-01

Pärnu tantsukool WAF Dance toob 17. ja 18. juunil Endla teatris lavale Saint-Exupery "Väikese printsi". See on moodsa tantsuteatri koolitus- ja etendusprojekt. Lavastaja ja koreograaf on Kate Pringle Londonist

Muusikamaailm : Berliini Filharmoonikute omalaadne kontserdireis. Klaverinädal Espoos. shtshedrini Klaverikontsert Los Angeleses. Domingo ja Pavarotti kõrvuti Metropolitanis. Pendereckile preemia Duisburgist / Priit Kuusk

Index Scriptorium Estoniae

Kuusk, Priit, 1938-

1999-01-01

Berliini Filharmoonikute kontsertreisist II Maailmasõja võitnud riikide pealinnades tähistamaks Saksa Liitvabariigi moodustamise 50. aastapäeva. 12.-17. okt. Soomes Espoos toimunud 5. rahvusvahelisest pianistide festivalist. R.shtshedrini Viienda Klaverikontserdi maailmaesiettekandest Los Angeleses 21. okt. L. Pavarotti laulab ooperis "Tosca"ja P. Domingo ooperites "Talupoja au" ning "Pajatsid" New Yorgi Metropolitan Operas. Tänavune Duisburgi Muusikapreemia anti K. Pendereckile

Surveillance Camera Players / Bill Brown ; interv. Tilman Baumgärtel

Index Scriptorium Estoniae

Brown, Bill

2006-01-01

New Yorgis tegutsevast rühmitusest SCP (Turvakaamera Esinejad), mille rajas Bill Brown (sünd. 1959), temaga 2001. a. jaanuaris tehtud meiliintervjuu. SCP etendab näidendeid turvakaamerate ees, Internetis jagab informatsiooni oma tegevuse kohta. Tekstis: "...kuna SCP keskendub turvakaameratele, kasutades nende loogikat selle tehnoloogia enda vastu, siis võib öelda, et nad töötavad kommunikatsioonivõrkudega"

Uudiseid maailmast / Nele-Eva Steinfeld

Index Scriptorium Estoniae

Steinfeld, Nele-Eva

2013-01-01

Lühisõnumeid muusikamaailmast: Michel van der Aa pälvis Grawemeyeri muusikaauhinna. Norra rahvusooper tellis Jüri Reinverelt ooperi "Peer Gynt". Dirigent Santtu-Matias Rouvali tõus. New Yorgi Filharmoonikud teevad koostööd Hiinaga. Lahkus Galina Višnevskaja. Suri Charles Rosen. Daniel Barenboim rajab Berliini uue muusikaakadeemia. Viiulikaupmehele vanglakaristus. Toronto linnast valmib sümfoonia jt.

Muusikamaailm : Baden-Badeni suvefestival. Festivalid lõppevad, hooajad algavad. Moskva Suur Teater muutumas. Põhjala ballett "Baldur" / Priit Kuusk

Index Scriptorium Estoniae

Kuusk, Priit, 1938-

2000-01-01

1.-13. sept. toimuvast Baden-Badeni muusikafestivalist, sealsest uuest kontserdimajast Festspielhaus. Muusikafestivalidest ئ Montreux' Voice&Music Festival; Schleswig-Holsteini festival; Salzburgi festival; London Proms; festival "Mostly Mozart" New Yorgis; Sydney Olympic Art Festival. Hooaja avaetendustest Hollandi, Edinburghi, Los Angelese Ooperis ja Opera de Lausanne'is. Moskva Suure Teatri uutest juhtidest. Uue balleti "Baldur" esietendustest Põhjamaade tänavustes kultuuripealinnades Reykjavikis, Bergenis ja Helsingis

Berliini kunstielu : aktuaalne, sõltumatu, internatsionaalne... ja vastuoluline / Heli Meisterson

Index Scriptorium Estoniae

Meisterson, Heli

2004-01-01

IX rahvusvahelisest kaasaegse kunsti messist "Art Forum Berlin", selle raames toimunud Zdenek Felixi kureeritud erinäitusest "Made in Berlin". Eesti kunstnikest olid messil esindatud Ene-Liis Semper ("Oasis", "Uks", esindas Hamburgi galerii Art Agents) ja Jaan Toomik (esindas IBID Projects). New Yorgi moodsa kunsti muuseumi väljapanekust Berliini uues rahvusgaleriis. Friedrich Christian Flicki kollektsiooni väljapanekust Hamburger Bahnhofis

Türi viin : aasta jagu pohmellita võidujoovastust / Cathryne Davis ; interv. Neeme Raud

Index Scriptorium Estoniae

Davis, Cathryne

2003-01-01

Ameerika Ühendriikides müüdavatest Eesti viinadest on kõige suurema edu saavutanud Türi vodka. New-Yorgi suhtekorraldusfirma Deussen Global Comunications'i esindaja Cathryne Davis näeb müügiedu põhjustena viina kõrget kvaliteeti, turundusalast koostööd rahvusvaheliselt tuntud Bacardi'ga, eliidile suunatud sponsorlust, ulatuslikku müügivõrku ja edukat reklaamikampaaniat

Majad ja muutumised marsruudil JPN-USA-EST / Tomomi Hayashi ; intervjueerinud Mait Väljas

Index Scriptorium Estoniae

Hayashi, Tomomi, 1971-

2011-01-01

Intervjuu Jaapanis Toyamas sündinud ning Eestis elava ja töötava arhitekti Tomomi Hayashiga, kes aastast 2004 on HG Arhitektuur OÜ arhitekt ja partner. Endast, tööst New Yorgis Rafael Viñoly büroos, Eestisse tulekust, oma tööpõhimõtetest, lemmikarhitektidest, järgmisest ehitusbuumist jm. Loetletud T. Hayashi töid, preemiad

Dimorphic effects of transforming growth factor-β signaling during aortic aneurysm progression in mice suggest a combinatorial therapy for Marfan syndrome.

Science.gov (United States)

Cook, Jason R; Clayton, Nicholas P; Carta, Luca; Galatioto, Josephine; Chiu, Emily; Smaldone, Silvia; Nelson, Carol A; Cheng, Seng H; Wentworth, Bruce M; Ramirez, Francesco

2015-04-01

Studies of mice with mild Marfan syndrome (MFS) have correlated the development of thoracic aortic aneurysm (TAA) with improper stimulation of noncanonical (Erk-mediated) TGFβ signaling by the angiotensin type I receptor (AT1r). This correlation was largely based on comparable TAA modifications by either systemic TGFβ neutralization or AT1r antagonism. However, subsequent investigations have called into question some key aspects of this mechanism of arterial disease in MFS. To resolve these controversial points, here we made a head-to-head comparison of the therapeutic benefits of TGFβ neutralization and AT1r antagonism in mice with progressively severe MFS (Fbn1(mgR/mgR) mice). Aneurysm growth, media degeneration, aortic levels of phosphorylated Erk and Smad proteins and the average survival of Fbn1(mgR/mgR) mice were compared after a ≈3-month-long treatment with placebo and either the AT1r antagonist losartan or the TGFβ-neutralizing antibody 1D11. In contrast to the beneficial effect of losartan, TGFβ neutralization either exacerbated or mitigated TAA formation depending on whether treatment was initiated before (postnatal day 16; P16) or after (P45) aneurysm formation, respectively. Biochemical evidence-related aneurysm growth with Erk-mediated AT1r signaling, and medial degeneration with TGFβ hyperactivity that was in part AT1r dependent. Importantly, P16-initiated treatment with losartan combined with P45-initiated administration of 1D11 prevented death of Fbn1(mgR/mgR) mice from ruptured TAA. By demonstrating that promiscuous AT1r and TGFβ drive partially overlapping processes of arterial disease in MFS mice, our study argues for a therapeutic strategy against TAA that targets both signaling pathways although sparing the early protective role of TGFβ. © 2015 American Heart Association, Inc.

Definitive Management of Oligometastatic Melanoma in a Murine Model Using Combined Ablative Radiation Therapy and Viral Immunotherapy

Energy Technology Data Exchange (ETDEWEB)

Blanchard, Miran [Department of Molecular Medicine, Mayo Clinic, Rochester, Minnesota (United States); Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota (United States); Shim, Kevin G. [Department of Molecular Medicine, Mayo Clinic, Rochester, Minnesota (United States); Department of Immunology, Mayo Clinic, Rochester, Minnesota (United States); Grams, Michael P. [Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota (United States); Rajani, Karishma; Diaz, Rosa M. [Department of Molecular Medicine, Mayo Clinic, Rochester, Minnesota (United States); Furutani, Keith M. [Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota (United States); Thompson, Jill [Department of Molecular Medicine, Mayo Clinic, Rochester, Minnesota (United States); Olivier, Kenneth R.; Park, Sean S. [Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota (United States); Markovic, Svetomir N. [Department of Immunology, Mayo Clinic, Rochester, Minnesota (United States); Department of Medical Oncology, Mayo Clinic, Rochester, Minnesota (United States); Pandha, Hardev [The Postgraduate Medical School, University of Surrey, Guildford (United Kingdom); Melcher, Alan [Leeds Institute of Cancer Studies and Pathology, University of Leeds, Leeds (United Kingdom); Harrington, Kevin [Targeted Therapy Laboratory, The Institute of Cancer Research, London (United Kingdom); Zaidi, Shane [Department of Molecular Medicine, Mayo Clinic, Rochester, Minnesota (United States); Targeted Therapy Laboratory, The Institute of Cancer Research, London (United Kingdom); Vile, Richard, E-mail: vile.richard@mayo.edu [Department of Molecular Medicine, Mayo Clinic, Rochester, Minnesota (United States); Department of Immunology, Mayo Clinic, Rochester, Minnesota (United States); Leeds Institute of Cancer Studies and Pathology, University of Leeds, Leeds (United Kingdom)

2015-11-01

Purpose: The oligometastatic state is an intermediate state between a malignancy that can be completely eradicated with conventional modalities and one in which a palliative approach is undertaken. Clinically, high rates of local tumor control are possible with stereotactic ablative radiation therapy (SABR), using precisely targeted, high-dose, low-fraction radiation therapy. However, in oligometastatic melanoma, virtually all patients develop progression systemically at sites not initially treated with ablative radiation therapy that cannot be managed with conventional chemotherapy and immunotherapy. We have demonstrated in mice that intravenous administration of vesicular stomatitis virus (VSV) expressing defined tumor-associated antigens (TAAs) generates systemic immune responses capable of clearing established tumors. Therefore, in the present preclinical study, we tested whether the combination of systemic VSV-mediated antigen delivery and SABR would be effective against oligometastatic disease. Methods and Materials: We generated a model of oligometastatic melanoma in C57BL/6 immunocompetent mice and then used a combination of SABR and systemically administered VSV-TAA viral immunotherapy to treat both local and systemic disease. Results: Our data showed that SABR generates excellent control or cure of local, clinically detectable, and accessible tumor through direct cell ablation. Also, the immunotherapeutic activity of systemically administered VSV-TAA generated T-cell responses that cleared subclinical metastatic tumors. We also showed that SABR induced weak T-cell-mediated tumor responses, which, particularly if boosted by VSV-TAA, might contribute to control of local and systemic disease. In addition, VSV-TAA therapy alone had significant effects on control of both local and metastatic tumors. Conclusions: We have shown in the present preliminary murine study using a single tumor model that this approach represents an effective, complementary

Definitive Management of Oligometastatic Melanoma in a Murine Model Using Combined Ablative Radiation Therapy and Viral Immunotherapy

International Nuclear Information System (INIS)

Blanchard, Miran; Shim, Kevin G.; Grams, Michael P.; Rajani, Karishma; Diaz, Rosa M.; Furutani, Keith M.; Thompson, Jill; Olivier, Kenneth R.; Park, Sean S.; Markovic, Svetomir N.; Pandha, Hardev; Melcher, Alan; Harrington, Kevin; Zaidi, Shane; Vile, Richard

2015-01-01

Purpose: The oligometastatic state is an intermediate state between a malignancy that can be completely eradicated with conventional modalities and one in which a palliative approach is undertaken. Clinically, high rates of local tumor control are possible with stereotactic ablative radiation therapy (SABR), using precisely targeted, high-dose, low-fraction radiation therapy. However, in oligometastatic melanoma, virtually all patients develop progression systemically at sites not initially treated with ablative radiation therapy that cannot be managed with conventional chemotherapy and immunotherapy. We have demonstrated in mice that intravenous administration of vesicular stomatitis virus (VSV) expressing defined tumor-associated antigens (TAAs) generates systemic immune responses capable of clearing established tumors. Therefore, in the present preclinical study, we tested whether the combination of systemic VSV-mediated antigen delivery and SABR would be effective against oligometastatic disease. Methods and Materials: We generated a model of oligometastatic melanoma in C57BL/6 immunocompetent mice and then used a combination of SABR and systemically administered VSV-TAA viral immunotherapy to treat both local and systemic disease. Results: Our data showed that SABR generates excellent control or cure of local, clinically detectable, and accessible tumor through direct cell ablation. Also, the immunotherapeutic activity of systemically administered VSV-TAA generated T-cell responses that cleared subclinical metastatic tumors. We also showed that SABR induced weak T-cell-mediated tumor responses, which, particularly if boosted by VSV-TAA, might contribute to control of local and systemic disease. In addition, VSV-TAA therapy alone had significant effects on control of both local and metastatic tumors. Conclusions: We have shown in the present preliminary murine study using a single tumor model that this approach represents an effective, complementary

99mTc-3PRGD2 scintigraphy to stage liver fibrosis and evaluate reversal after fibrotic stimulus withdrawn

International Nuclear Information System (INIS)

Zhang, Xin; Guo, Qiyong; Shi, Yu; Xu, Weina; Yu, Shupeng; Yang, Zhiguang; Cao, Li; Liu, Changping; Zhao, Zhoushe; Xin, Jun

2017-01-01

Objective: Scintigraphy using 99mTc-3PRGD2 targeting integrin αvβ3 could assess activation of hepatic stellate cells (HSCs). Liver fibrogenesis is intimately associated with activation of HSCs, and the fibrolytic process is accompanied by the reduction of the activated HSCs. In this study, we aimed to evaluate the feasibility of this method to assess the severity of liver fibrosis and the reversal after the fibrotic stimulus withdrawal. Methods: Liver fibrosis of different stages was induced by thioacetamide (TAA) injection for 2, 4 and 6 weeks (n = 6 for each time point). Another 6 rats with 8-week TAA administration (the 8-week group) and 6 rats which were injected with TAA for 6 weeks, and then withdrawn of TAA for 2 weeks (spontaneous recovery rats, SRR) were designed. The ratios of radioactivity detected in the liver vs. the heart at 30 min post-injection of 99m Tc-3PRGD2 (L/H30 min ), the collagen proportionate area (CPA), the protein and mRNA levels of integrin α v , integrin β 3 were analyzed and compared among groups. Results: The Ishak stage scores of the livers in the control and 2, 4, 6-week groups increased when the TAA administration period was extended. L/H30 min increased with the upgrading of liver fibrosis and the differences between each pair of groups were statistically significant (p 30 min in the 8-week group was similar to that in the 6-week group (p > 0.05), but was significantly higher than that in the SRR group (p = 0.005). Conclusions: Scintigraphy using 99m Tc-3PRGD2 may provide a non-invasive method for grading liver fibrosis and assessing liver fibrosis reversal.

Texas, Rosie ja Helga KitKat Clubist : endised varieteestaarid Ülle Toming, Reet Paavel ja Laine Mägi astuvad taas lavale / Ülle Toming, Reet Paavel, Laine Mägi ; interv. Verni Leivak

Index Scriptorium Estoniae

Toming, Ülle, 1955-

2003-01-01

Vanalinnastuudio muusikal "Cabaret". Intervjuu omaaegsete varieteetähtedega: Laine Mägi, Ülle Toming ja Reet Paavel moodustavad muusikalis "Cabaret" osa koorist, kel tuleb üle hulga aja laulda, tantsida ja näidelda väga erinevates rollides. Lisaks nende tutvustus "Kolm graatsiat"

Muusikamaailm : Sibeliuse preemia laureaat on Ligeti. Uusooperid Turus, Milanos, Barcelonas. Aasta dirigent on Daniel Barenboim / Priit Kuusk

Index Scriptorium Estoniae

Kuusk, Priit, 1938-

2000-01-01

Wihuri fondi Sibeliuse preemia sai G. Ligeti. Uusooperitest Turu toomkirikus, Milano La Scala ja Barcelona Gran Teatre del Liceu laval. D. Barenboim pälvis heliplaadipreemia Echo Klassik koos aasta dirigendi 2000 tiitliga

Kino-Mati näitab Rakveres kino / Tiit Tuumalu

Index Scriptorium Estoniae

Tuumalu, Tiit, 1971-

2001-01-01

Rakveres tuli lavale Toomas Raudami ja Peeter Simmi näidend Lõuna-Eesti kinomehaaniku Mati Parkja elust "Kino-Mati. Tema elutee ja juhtumised, mis seal ette tulid". Lavastas Peeter Simm, nimiosas Erik Ruus

"Minu veetlev leedi" jääb ära

Index Scriptorium Estoniae

2004-01-01

Smithbridge Productionsi väljakuulutatud muusikali ärajäämisest, 5. nov. Linnahalli lavale jõydvast muusikalist "Hull sinu järele". 2005. a. detsembis etenduvast konkurwndi Tequila muusikalist "Minu veetlev leedi"

Otsekui Kaval-Ants ja Vanapagan klassiku näidendis / Enn Siimer

Index Scriptorium Estoniae

Siimer, Enn, 1946-

2009-01-01

Ugala suvelavastus, Kalju Komissarovi lavastatud Bertolt Brechti "Härra Punttila ja tema sulane Matti". Mängitake Ugala tiigi kõrvale ehitatud laval. Osades: härra Punttila - Peeter Tammearu, sulane Matti - Indrek Sammul

Jim Ashilevi jõuab 22-aastaselt kõike. Millele ta pidama jääb? / Jim Ashilevi ; interv. Kaarel Kressa

Index Scriptorium Estoniae

Ashilevi, Jim, 1984-

2006-01-01

Kirjanik, kelle näidendit "Nagu poisid vihma käes" valmistub lavale tooma "Endla" teater, audiovisuaalset meediat õppiv TLÜ tudeng, kel valmimas bakalaureusetööna situatsioonikomöödiaseriaali "Sireenid" pilootseeria

Ot "Printsessõ Alissii" k "Hrabromu Rikki-Tikki-Tavi" / Eteri Kekelidze

Index Scriptorium Estoniae

Kekelidze, Eteri, 1944-

2000-01-01

Tallinna muusikateater Väike Ooper jõudis tagasi Moskva külalisetendustelt, kus Eesti Saatkonnas esitati Boriss Kisseljovi lasteooper ""Printsess Alicia". Sügisel valmistub lasteteater lavale tooma helilooja uut ooperit "Julge Rikki-Tikki- Taavi"

ABBA-muusikal on aprillis Saku hallis / Mari Sarv

Index Scriptorium Estoniae

Sarv, Mari, 1978-

2004-01-01

West Endi muusikaliteatri ABBA muusikal põhinevat rändmuusikali "Mamma mia" etendatakse aprillis kaheksa korda Saku suurhalli laval. Muusikali libretist on C. Johnson ja muusika autorid B. Andersson ja B. Ulvaeus ansamblist ABBA

Miinusmärgiga maagia / Margit Tõnson

Index Scriptorium Estoniae

Tõnson, Margit, 1978-

2009-01-01

Mehhiko kirjaniku Juan Rulfo novelli "Pedro Paramo" põhjal tehtud Ingomar Vihmari samanimelisest lavastusest Eesti Draamateatris. Kunstnikutöö Ervin Õunapuult, kelle lavakujundust võrreldakse Hendrik Toompere jun. lavastusega "Sada aastat..." Vanemuise laval

Jõhvi teeb j'älle Tallinnale ära / Tiit Tuumalu

Index Scriptorium Estoniae

Tuumalu, Tiit, 1971-

2008-01-01

Seoses Age Oksa balletikarjäärist loobumisega võiks Estonia teha sümboolse zhesti ja kutsuda nad oma lavale tantsima. Inglise Rahvuslikus Balletis tantsinud Age Oksa jaoks oli Estonia tema esimene koduteater

Liisa Smith : kaalun Tallinnas lavastamist / Liisa Smith ; interv. Andris Feldmanis

Index Scriptorium Estoniae

Smith, Liisa

2007-01-01

Londonis elaval eestlasest teatrilavastajal Liisa Smithil, kes tõi seal mullu lavale Jaan Tätte tüki "Ristumine peateega", on nüüd valminud uus lavastus - iirlase Marina Carri "On Raftery's Hill"

Tim Burton lavastab Batmani muusikali. Placido Domingo palkas "Star Warsi" võluri. MTV muusikaauhindade show'l narriti Michael Jacksonit. Hendrixi põlenud kitarr läheb müüki

Index Scriptorium Estoniae

2002-01-01

Jim Steinman kirjutab muusikat Tim Burtoni 2005. aastal lavale tulevale Batmani muusikalile. Los Angelese ooperimaja juht Domingo palkas George Lucase Wagneri ooperi "Nibelungide sõrmus" eriefektide ettevalmistamiseks. Britney Spears nimetas Michael Jacksonit Millenniumi artistiks.

Moeuudised

Index Scriptorium Estoniae

1998-01-01

Yohji Yamamoto moeshowl astusid lavale Vivienne Westwood, Ines de la Fressage jt. Modell Eva Herzigovast. Austraalia moenädalal esinenud edukaid austraalia moekunstnikke : Colette Dinnigan (nimekaim), Zimmerman, Charlie Brown, Zambesi, Nicola Finetti, Nicholas Blanchet.

The Levels Of Cytokines And S 100β Which Associated With The Pathogenesis Of Hepatic Encephalopathy In Rats: Role Of Lactulose And N-Acetylcysteine In Its Treatment

International Nuclear Information System (INIS)

Heibashy, M.I.A.; Mazen, G.M.A.; Ibrahim, M.A.

2012-01-01

Hepatic encephalopathy (HE) is a reversible syndrome of impaired brain function occurring in patients with advanced liver failure. Recently, it has been reported that pro inflammatory cytokines are involved in the pathogenesis of brain oedema during HE. This study was conducted to elucidate the changes of plasma and brain pro inflammatory cytokines in encephalopathy rats and to evaluate the hepato-protective activity of lactulose or N-acetylcysteine against thioacetamide (TAA) induced hepatopathy in rats. Acute hepatic encephalopathy (HE) in rats was induced by intraperitoneal injection of thioacetamide in 24 hours intervals for two consecutive days. The obtained results revealed significant increase (P<0.05) in liver function tests (ALT, AST, ALP, bilirubin), ammonia, nitric oxide and total oxidant capacity (TOC) in TAA rats than those in control ones. Brain water content was significantly elevated in TAA rats as compared with the control. In addition, the levels of pro inflammatory cytokines (IL-1Β, IL-6, TNF-α) in both serum and brain were significantly increased associated with a remarkable elevation in the level of serum S 100β in TAA rats. On the other hand, induction of hepatic encephalopathy caused significant decrease (P<0.05) in total antioxidant capacity (TAC) levels. When HE rats group was treated with lactulose or N-acetylcysteine, considerable amelioration effects in all previous studied parameters were pronounced dependent on certain mechanisms

The influence of ripening stage and cultivation system on the total antioxidant activity and total phenolic compounds of yellow passion fruit pulp.

Science.gov (United States)

Macoris, Mariana S; De Marchi, Renata; Janzantti, Natália S; Monteiro, Magali

2012-07-01

This work aimed to investigate the influence of both ripening stage and cultivation system on the total phenolic compounds (TPC) and total antioxidant activity (TAA) of passion fruit pulp. TPC extraction was optimized using a 2³ central composed design. The variables were fruit pulp volume, methanol volume and extraction solution volume. TPC was determined using the Folin-Ciocalteu reaction, and TAA using the ABTS radical reaction. The conditions to extract TPC were 2 mL passion fruit pulp and 9 mL extraction solution containing 40% methanol:water (v/v). TPC values increased in the passion fruit pulp during ripening for both cultivation systems, ranging from 281.8 to 361.9 mg gallic acid L⁻¹ (P ≤ 0.05) for the organic pulp and from 291.0 to 338.6 mg gallic acid L⁻¹ (P ≤ 0.05) for the conventional pulp. TPC values increased during ripening for both organic and conventional passion fruit. The same was true for TAA values for conventional passion fruit. For organic passion fruit, however, TAA values were highest at the initial ripening stages. These results suggest that antioxidant compounds exert strong influence on the initial ripening stages for organic passion fruit, when TPC still did not reach its maximum level. Copyright © 2012 Society of Chemical Industry.

Application of metabonomics on an experimental model of fibrosis and cirrhosis induced by thioacetamide in rats

International Nuclear Information System (INIS)

Constantinou, Maria A.; Theocharis, Stamatios E.; Mikros, Emmanuel

2007-01-01

Metabonomics has already been used to discriminate different pathological states in biological fields. The metabolic profiles of chronic experimental fibrosis and cirrhosis induction in rats were investigated using 1 H NMR spectroscopy of liver extracts and serum combined with pattern recognition techniques. Rats were continuously administered with thioacetamide (TAA) in the drinking water (300 mg TAA/L), and sacrificed on 1st, 2nd, and 3rd month of treatment. 1 H NMR spectra of aqueous and lipid liver extracts, together with serum were subjected to Principal Component Analysis (PCA). Liver portions were also subjected to histopathological examination and biochemical determination of malondialdehyde (MDA). Liver fibrosis and cirrhosis were progressively induced in TAA-treated rats, verified by the histopathological examination and the alterations of MDA levels. TAA administration revealed a number of changes in the 1 H NMR spectra compared to control samples. The performance of PCA in liver extracts and serum, discriminated the control samples from the fibrotic and cirrhotic ones. Metabolic alterations revealed in NMR spectra during experimental liver fibrosis and cirrhosis induction, characterize the stage of fibrosis and could be illustrated by subsequent PCA of the spectra. Additionally, the PCA plots of the serum samples presented marked clustering during fibrosis progression and could be extended in clinical diagnosis for the management of cirrhotic patients

PASS-Predicted Hepatoprotective Activity of Caesalpinia sappan in Thioacetamide-Induced Liver Fibrosis in Rats

Directory of Open Access Journals (Sweden)

Farkaad A. Kadir

2014-01-01

Full Text Available The antifibrotic effects of traditional medicinal herb Caesalpinia sappan (CS extract on liver fibrosis induced by thioacetamide (TAA and the expression of transforming growth factor β1 (TGF-β1, α-smooth muscle actin (αSMA, and proliferating cell nuclear antigen (PCNA in rats were studied. A computer-aided prediction of antioxidant and hepatoprotective activities was primarily performed with the Prediction Activity Spectra of the Substance (PASS Program. Liver fibrosis was induced in male Sprague Dawley rats by TAA administration (0.03% w/v in drinking water for a period of 12 weeks. Rats were divided into seven groups: control, TAA, Silymarin (SY, and CS 300 mg/kg body weight and 100 mg/kg groups. The effect of CS on liver fibrogenesis was determined by Masson’s trichrome staining, immunohistochemical analysis, and western blotting. In vivo determination of hepatic antioxidant activities, cytochrome P450 2E1 (CYP2E1, and matrix metalloproteinases (MPPS was employed. CS treatment had significantly increased hepatic antioxidant enzymes activity in the TAA-treated rats. Liver fibrosis was greatly alleviated in rats when treated with CS extract. CS treatment was noted to normalize the expression of TGF-β1, αSMA, PCNA, MMPs, and TIMP1 proteins. PASS-predicted plant activity could efficiently guide in selecting a promising pharmaceutical lead with high accuracy and required antioxidant and hepatoprotective properties.

Emergency cooling system with hot-water jet pumps for nuclear reactors

International Nuclear Information System (INIS)

Reinsch, A.O.W.

1977-01-01

The ECCS for a PWR or BWR uses hot-water jet pumps to remove the thermal energy generated in the reactor vessel and stored in the water. The hot water expands in the nozzle part (Laval nozzle) of the jet pump and sucks in coolant (borated water) coming from a storage tank containing subcooled water. This water is mixing with the hot water/steam mixture from the Laval nozzle. The steam is condensed. The kinetic energy of the water is converted into a pressure increase which is sufficient to feed the water into the reactor vessel. The emergency cooling may further be helped by a jet condenser also operating according to the principle of a jet pump and condensing the steam generated in the reactor vessel. (DG) [de

Londonis annavad tooni "Ooperifantoom" ja tsirkus / Erkki Otsman

Index Scriptorium Estoniae

Otsman, Erkki, 1966-

2007-01-01

Eesti kabareeartist Erkki Otsman külastas Euroopa muusikalipealinna Londonit ja vaatas ära juba 20 aastat laval püsinud Andrew Lloyd Webberi "Ooperifantoomi" ning Montreali tsirkusetrupi Cirque du Soleil etenduse Royal Albert Hallis

Uuslavastused Ugalas / Helle Leppik

Index Scriptorium Estoniae

Leppik, Helle

2007-01-01

Ugalas käib töö nelja uuslavastusega : Ott Aardam lavastab "Börs ja Börsitar", Helen Rekkor toob lavale "Nora/Maja", Peeter Tammearu suvelavastus on "Sirelikassid" ja Margus Vaher lavastab suvelavastuse "Naabri Mari"

Mladen Kiselov: olen õnnelik, et olen Eestis / Andres Laasik

Index Scriptorium Estoniae

Laasik, Andres, 1960-2016

2009-01-01

Bulgaaria lavastajast ja teatripedagoogist Mladen Kiselovist, kelle käe all tuleb sel hooajal Eestis lavale kaks tükki - Edward Albee` "Kes kardab Virginia Woolfi?" Tallinna Linnateatris ja Sam Shepardi "Maetud laps" Tartu Sadamateatris

Tvortsheski duhh i teatralnõje bratstvo / Kristiina Nurme

Index Scriptorium Estoniae

Nurme, Kristiina

2008-01-01

Vene Kultuurikeskuse teater ART-Grotesk osales rahvusvahelisel noorte harrastusteatrite festivalil Leedus ja võitis esikoha oma lavastusega "Õnnelik" Oscar Wilde'i teose "Õnnelik prints" järgi. Teose on lavale seadnud Tatjana Buinova

Николай Цискаридзе: Корона с меня не упадет / Николай Цискаридзе ; интервьюировала Тамара Унанова

Index Scriptorium Estoniae

Цискаридзе, Николай, 1973-

2009-01-01

19. nov. Tallinnas Nokia kontserdimajas etendunud rahvusvahelises balletiprogrammis "Tantsukuningad - Kings of Dance maailmatuur 2009" astus lavale ka gruusia päritolu Moskva Suure Teatri tantsija Nikolai Tsiskaridze. Intervjuus endast, oma töödest-tegemistest

Sanctions for unlawful collective action in the Nordic countries and Germany / Niklas Bruun, Caroline Johansson

Index Scriptorium Estoniae

Bruun, Niklas

2014-01-01

Terve ajakirja number on pühendatud ebaseadusliku kollektiivse tegutsemise regulatsioonile, töötajate streigiõigusele ning teenuste osutamise vabadusele erinevates riikides. Euroopa Kohtu lahendid Laval (C-341/05) ja Viking (C-438/05)

Laienemisest taasühinemiseni / Per Stenmarck

Index Scriptorium Estoniae

Stenmarck, Per

2003-01-01

Ilmunud ka: Proceedings of the 9th international conference "Estonia and the European Union: Estonia on its way to a changing Europe" : October 30-November 1, 2002, Tallinn, Estonian National Library. - Tallinn, lk. 70-72. Euroopa Parlamendi ja EL-Eesti parlamentaarse ühiskomitee liige kandidaatriikide Euroopa Liiduga ühinemise ajaloolisest tähtsusest

Linnahalli saatus taas savijalgadel / Andres Eilart

Index Scriptorium Estoniae

Eilart, Andres

2009-01-01

Tallinnas viibis Tallinna Linnahalli ja selle ümbruse arendamisest huvituva Tallinn Entertainment LLC esindaja arhitekt Jack Weinand, kes kinnitas, et linnahalli väljanägemises ei tule muutusi. Tallinna ja Tallinn Entertainment LLC vahel sõlmitud eellepingust

Moostes taas mõtte- ja kunstitalgud

Index Scriptorium Estoniae

2002-01-01

17. ja 18. VIII lõpetatakse Moostes teised "Postsovkhozi" mõtte- ja keskkonnakunsti talgud "Kihid". Organiseerijad Evelyn Müürsepp ja Maia Möller. Moostes nädal aega elanud ja loonud kunstnikud. Seminari kavast, esinejatest, filmiprogrammist

Vene turistid tulevad taas / Hille Tressum

Index Scriptorium Estoniae

Tressum, Hille

2008-01-01

Statistikaameti andmetel on sel aastal märkimisväärselt kasvanud Vene ja Soome turistide arv, veebruaris oli nende ööbimisi Eestis 2006. aasta sama perioodiga võrreldes vastavalt 16,4% ja 7,2% rohkem. Diagramm

Pinochet taas trellide taga / Kalev Vilgats

Index Scriptorium Estoniae

Vilgats, Kalev

2005-01-01

Santiagos vahistati Tšiili endine diktaator Augusto Pinochet, keda süüdistatakse maksupettuses ja passide võltsimises seoses salajaste pangaarvetega, millel on hoiustatud miljoneid dollareid valenimede all USA-s ja teistes riikides

Ufo on taas maandunud! / Urmas Oja

Index Scriptorium Estoniae

Oja, Urmas, 1981-2012

2005-01-01

1970. aastatel soome arhitekti Matti Suuroneni projekteeritud lendavat taldrikut meenutavast plastikust tulevikumajast Futoro, millest üks toodi 1995. a. Halinga keskuse juurde Pärnumaal ja praegu asub Tallinna lähedal. Maja valmistati Soome plasttoodete tehases Polykem. Soomlaste ufomajade ehitamise teostamata plaanist. 8 ill

Inglismaal jagati taas D&AD auhindu

Index Scriptorium Estoniae

2008-01-01

Keskkonnakujunduse kategoorias tõsteti 2007. a. esile: Heathrow Terminal 5 klubi (arhitektid Chris Bagot, Oliver Salway, disainerid Joe Ferry, Emma Lally, Monique van der Hurk, Hillary Clark jt.), Lohringi metroojaam Bohumis (Rübsamen & Partner, kunstnikud Eva-Maria Joeressen, Klaus Kessner), kauplus Freitag Zürichis (arhitektid Harald Echsle, Annette Spillmann, disainerid Daniel ja Markus Freitag)

Tantsupäev toob taas auhinnad

Index Scriptorium Estoniae

2008-01-01

Philip Morrise kaasaegse tantsu auhinnale kandideerivad aasta tegija kategoorias int.act.union ja Taavet Jansen teosega "Algorytm", Oksana Titova teosega "Hamlet", Renate Valme teosega "Idula" ning Mairika Plakso ja Margus Toomla teosega "The Story of M. & M. Part II". Laureaadid kuulutatakse välja vahetult enne rahvusvahelist tantsupäeva

Palmse supelmaja taas kasutusel / Anneliis Aunapuu

Index Scriptorium Estoniae

Aunapuu, Anneliis

1998-01-01

Lahemaa Rahvuspark rentis poolelioleva supelmaja perekond Ong'ile, kes ehituse lõpetas, hoone sisustas ja avas kohvik-restorani 'Freifrau Isabella'. Sisekujundus autor Leila Pärtelpoeg nimetab sisekujundust palladiaanlikuks. Tänu AEL ja Tartu Kunstikooliga sõlmitud lepingule sai supelmaja kõrgetasemelise maalritöö. Maalingud eesruumis ئ Eve Erman. Sepisvalgustid ئ Ülo Sepp. Pika-laua-saalis oleva von Pahlenite vapi valmistas Andres Sapar. Inkrusteeritud puhvetkapi taastas Urmas Ong.

Uuno Turhapuro taas kinoekraanil / Andres Laasik

Index Scriptorium Estoniae

Laasik, Andres, 1960-2016

2004-01-01

Komöödiafilm "Uuno Turhapuro - This is my life" : režissöör Ere Kokkonen : nimiosas Vesa-Matti Loiri : Soome 2004. See on sama peategelasega 19. film. Kõigi eelnevate filmide produtsent oli mõne aasta eest surnud Spede Pasanen

Aeg vaadata taas Citigroupi / Peeter Teder

Index Scriptorium Estoniae

Teder, Peeter

2006-01-01

Vaatamata USA ühe suurima panga Citigroup kasumi kasvule on ettevõttel siiski pärast Enroni ja WorldComi skandaale raskusi investorite leidmisega. Diagramm: Citigroupi aktsia on vaid paar korda käinud 50 dollari tasemest kõrgemal. Vt. samas: Kasvuvõimega pank

Meediareklaam taas kasvutrendis / Külli Esko

Index Scriptorium Estoniae

Esko, Külli

2006-01-01

TNS Emori reklaamipanuste monitooringu AdEx andmetel oli meediareklaamituru käive käesoleva aasta esimeses kvartalis 279 miljonit krooni, kasv võrreldes eelmise aastaga 17%. Diagramm: Meediatüüpide reklaamimahud

Serbia liigub taas Euroopa Liidu poole

Index Scriptorium Estoniae

2007-01-01

Euroopa Liit kutsub Serbia jätkama kõnelusi riigi pürgimiseks ühenduse liikmeks, tõuke kõneluste jätkamiseks andis Haagi peasüüdistaja ja Serbia senise tugeva kritiseerija Carla Del Ponte rahulolu Belgradi pingutustega Balkani sõjakurjategijate väljaandmisel

Progressive Pearling of Barley Kernel: Chemical Characterization of Pearling Fractions and Effect of Their Inclusion on the Nutritional and Technological Properties of Wheat Bread.

Science.gov (United States)

Blandino, Massimo; Locatelli, Monica; Sovrani, Valentina; Coïsson, Jean Daniel; Rolle, Luca; Travaglia, Fabiano; Giacosa, Simone; Bordiga, Matteo; Scarpino, Valentina; Reyneri, Amedeo; Arlorio, Marco

2015-07-01

Two hulled barley varieties have been sequentially pearled for one to eight cycles, each with 5% removal. The derived fractions were analyzed for their bioactive compound content. The dietary fiber (DF) decreased from the external to the internal layers, whereas β-glucans showed an inverse trend. Deoxynivalenol contamination was concentrated in the outer layers. The total antioxidant activity (TAA) was higher in the 15-25% fractions, which were used to prepare bread. Five mixtures of refined wheat flour, with an increasing replacement of this pearled barley fraction, were compared with a control for the bioactive compound content, as well as for the rheological and physical bread properties. The inclusion of pearled fractions with up to a 10% substitution leads to a clear enhancement of the DF and TAA, with only minor detrimental effects on the physical parameters. Selected byproducts of barley pearling could be proposed as functional ingredients for bakery products rich in DF and TAA.

Structure, vibrations, and hydrogen bond parameters of dibenzotetraaza[14]annulene

Science.gov (United States)

Gawinkowski, S.; Eilmes, J.; Waluk, J.

2010-07-01

Geometry and vibrational structure of dibenzo[ b, i][1,4,8,11]tetraaza[14]annulene (TAA) have been studied using infrared and Raman spectroscopy combined with quantum-chemical calculations. The assignments were proposed for 106 out of the total of 108 TAA vibrations, based on comparison of the theoretical predictions with the experimental data obtained for the parent molecule and its isotopomer in which the NH protons were replaced by deuterons. Reassignments were suggesteded for the NH stretching and out-of-plane vibrations. The values of the parameters of the intramolecular NH⋯N hydrogen bonds were analysed in comparison with the corresponding data for porphyrin and porphycene, molecules with the same structural motif, a cavity composed of four nitrogen atoms and two inner protons. Both experiment and calculations suggest that the molecule of TAA is not planar and is present in a trans tautomeric form, with the protons located on the opposite nitrogen atoms.

Ameliorative Effect of Camel's Milk and Nigella Sativa Oil against Thioacetamide-induced Hepatorenal Damage in Rats.

Science.gov (United States)

Ahmad, Aftab; Al-Abbasi, Fahad A; Sadath, Saida; Ali, Soad Shaker; Abuzinadah, Mohammed F; Alhadrami, Hani A; Mohammad Alghamdi, Anwar Ali; Aseeri, Ali H; Khan, Shah Alam; Husain, Asif

2018-01-01

Camel milk (CM) and Nigella sativa (NS) have been traditionally claimed to cure wide range of diseases and used as medicine in different part of world, particularly in Saudi Arabia. Several research studies have been published that proved beneficial effects of CM and NS. This study was undertaken to investigate the antihepatotxic potential of CM and NS oil (NSO) against thioacetamide (TAA)-induced hepato and nephrotoxicity in rats. Thirty female Albino Wistar rats were randomly divided in to six groups having five rats in each group. A single subcutaneous injection of TAA (100 mg/kg b. w.) was administered to all the rats in Group-II to VI on 1 st day to induce hepatorenal damage. Group I served as a normal control while Group II served as toxic control for comparison purpose. Experimental animals in Group III, IV, and V were supplemented with fresh CM, (250 mL/24 h/cage), NSO (2 mL/kg/day p. o.), and NSO + fresh CM, respectively. Group VI was treated with a polyherbal hepatoprotective Unani medicine Jigreen (2 mL/kg/day p. o.) for 21 days. TAA-induced hepatorenal damage and protective effects of CM and NSO were assessed by analyzing liver and kidney function tests in the serum. Histopathology of liver and kidney tissues was also carried out to corroborate the findings of biochemical investigation. The results indicated that the TAA intoxicated rats showed significant increase in the alanine transaminase, aspartate transaminase, gamma-glutamyl transpeptidase, alkaline phosphatase, lipid profile, urea, creatinine, uric acid, sodium, and potassium levels in serum. Treatment of rats with CM, NSO, and CM plus NSO combination and Jigreen significantly reversed the damage and brought down the serum biochemical parameters and lipid profile toward the normal levels. The histopathological studies also support the hepato and nephroprotective effects of CM and NSO. This study demonstrated the ameliorative effects of CM, NSO, and CM plus NSO combination against TAA

Vene lavastaja: teater peab olema ühiskondliku diskussiooni keskuseks / Filipp Los ; intervjueerinud Taavi Minnik

Index Scriptorium Estoniae

Los, Filipp, 1967-

2016-01-01

Intervjuu Rakvere teatri juures külalislavastajana tegutseva Filipp Losiga Moskvast, kes tõi lavale Vladimir Žerebtsovi näidendi "Ausammas". Lavastusest, teatrist ja selle juurde kuuluvast Eestis ja Venemaal, ka nende ühiskondades toimuvast

Kas me sellist eesti keelt tahtsime? / Anu Lamp ; interv. Andres Keil

Index Scriptorium Estoniae

Lamp, Anu, 1958-

2006-01-01

24. märtsil esietendus teatris NO99 lavakunstikooli 22. lennu viimane diplomilavastus "Keeleuuenduse lõpmatu kurv". Lavastaja Anu Lamp räägib eesti keelest ja sellest, kuidas materjal Johannes Aaviku keeleuuendusest lavale jõudis

Peeter Simm kolmandat korda teatris

Index Scriptorium Estoniae

2001-01-01

Rakveres tuli lavale Toomas Raudami ja Peeter Simmi näidend Lõuna-Eesti kinomehaaniku Mati Parkja elust "Kino-Mati. Tema elutee ja juhtumised, mis seal ette tulid". Lavastas Peeter Simm, nimiosas Erik Ruus, kunstnik Hardi Volmer

E-Government for Good Governance in Developing Countries ...

International Development Research Centre (IDRC) Digital Library (Canada)

2014-05-01

May 1, 2014 ... In this book, Kettani and Moulin develop their findings and methods from the eFez ... practitioners, and decision makers in developing countries. ... Science and Software Engineering, Laval University, Québec City, Canada.

Tänu Gary Schwartzile / Helena Risthein

Index Scriptorium Estoniae

Risthein, Helena, 1954-

2011-01-01

New Yorgis sündinud ja õppinud, Hollandis elavast kunstiteadlasest, hollandi kunsti spetsialistist Gary Schwartzist, tema töödest. 17. ja 18. augustil külastasid Gary ja Loekie Schwartz Eesti Kunstimuuseumi filiaale. Gary Schwartzi rajatud Madalmaade kunsti hoidjate ja uurijate rahvusvahelisest ühingust CODART, mille konverentsidest ja õppereisidest on ka eesti kunstiteadlased osa võtnud. Ühingu häälekandjast CODART Courant

Bagatellid : maailm / Nele-Eva Steinfeld, Ivo Heinloo

Index Scriptorium Estoniae

Steinfeld, Nele-Eva

2011-01-01

Muusikasõnumeid maailmast: Hollandi kultuurielu kriis. Toetus Londoni Filharmooniaorkestrist vallandatud muusikutele. Veebilehest: arkivmusic.eu. Lahkus Kurt Sanderling. Hiinas keelustati ajaloolise sisuga ooper. Dirigent Mark Gorenstein vallandati ametist. Beethoveni kvarteti taastatud osa. Värskeid plaadilepinguid. Bostoni sümfooniaorkester otsib muusikalist juhti. Fabio Luisil probleem kodumaiste ooperimajadega. Itaalia jazzi pevad New Yorgis. Värskeid plaate jazzimaailmast. Tony Bennett purustas rekordi. DownBeati aasta jazzmuusik on Jason Moran

Talv 2015 = Winter 2015

Index Scriptorium Estoniae

2015-01-01

Aasta võitjad: Mart Kalm EKA rektoriks, Jaanus Samma Veneetsia biennaalil, Kris Lemsalu New Yorgi kunstimessil, Anu Vahtrale Köler Prize 2015, Raymond Pettiboni ja Marko Mäetamme isiknäitused Kumus, Katja Novitskova MoMa-s, Tanja Muravskajale Sadolini kunstipreemia, Tõnis Saadojale Konrad Mäe medal ja preemia, EKKM uued tegevjuhid on Marten Esko ja Johannes Säre, kunstnikupalka hakkavad saama viis Eesti kunstnikku

Uudised : Silver Ainomäe võit Roomas. "edition 49" edu Frankfurdis. "Võluflööt" New Yorgist / Valdo Preema

Index Scriptorium Estoniae

Preema, Valdo

2001-01-01

S. Ainomäe võitis Roomas noorte kammermuusikakonkursi "Verdi note" keelpillikategoorias I preemia ja II koha Sibeliuse akadeemia klarnetitrio koosseisus konkursil "Giovani concertisti". 7.-11. märtsini toimunud Frankfurdi rahvusvahelisel muusikamessil äratas tähelepanu muusikakirjastuse "edition 49" koostatud elektrooniline andmebaas Musicians Data Base. "Klassikaraadio" kannab 17. märtsil New Yorgi Metropolitan Operast üle Mozarti ooperi "Võluflööt" etenduse

Teejuht Õunpuu juurde / Tiit Tuumalu

Index Scriptorium Estoniae

Tuumalu, Tiit, 1971-

2010-01-01

Rahvusvahelise autorifilmi uue põlvkonna kõige silmapaistvamaid režissööre tutvustavast raamatust "Take 100. The Future of Film : 100 New Directors". Raamatus on eraldi peatükk eesti režissöörist Veiko Õunpuust ja tema filmist "Sügisball". 17. septembrist New Yorgi ja 1. oktoobrist Los Angelese kinos hakkab jooksma Veiko Õunpuu film "Püha Tõnu kiusamine"

Võdin vabastab rasvast / Alo Lõhmus

Index Scriptorium Estoniae

Lõhmus, Alo

2007-01-01

Vt. ka Postimees : na russkom jazõke 9. nov., lk. 11. New Yorgi Stony Brooki ülikooli biotehnoloogia keskuse direktor Clinton T. Rubin avaldas ajakirjas Proceedings of the National Academy of Sciences uudise, et hiir, kes viibib iga päev 15 minutit ülikerge vibratsiooni käes, saab 15 nädalaga lahti 27% senisest keharasvast ning tema luud on muutunud samavõrra toekamaks

Tuhkatriinust printsessiks / Heie Treier

Index Scriptorium Estoniae

Treier, Heie, 1963-

1999-01-01

Ida- ja Kesk-Euroopa 1990ndate kunsti näitus 'Pärast müüri' ('After the Wall') Stockholmis Moderna Museetis. Kureerinud David Elliott, Bojana Pejic, Iris Müller-Westermann. Seminarist. Eesti kunstnike Jaan Toomiku, Kai Kaljo, Liina Siibi, Inessa Josingu esinemisest. Kommenteerivad Moskva kuraator J. Bakstein, rootsi kunstikriitik C. Chambert, makedoonia kuraator S. Milevska, ajakirja NU toimetaja J.-P. Nilsson, New Yorgi kunstikriitik K. Levin

Üle ühe : Ugala külalisetendused Tallinnas / Valle-Sten Maiste

Index Scriptorium Estoniae

Maiste, Valle-Sten, 1972-

1995-01-01

J. Glowacki 'Antigone New Yorgis' (lav. P. Raudsepp); D. Goweri 'Issid' (lav. J. Allik); A. Christie' 'Lõpp on algus' (lav. P. Tammearu); 'La Traviata öö' (A. Dumas' 'Kameeliadaami' ja G. Verdi 'Traviata' ainetel. A. Noormetsa tekst ja lavastus); 'Kolm päeva parun von Münchhauseni elust' (G. Gorini stsenaariumi järgi Ü. Saaremäe ja A. Trallmanni tekst, Ü. Saaremäe lavastus)

New Laval facility for polarization measurements

Energy Technology Data Exchange (ETDEWEB)

Pouliot, J; Roy, R; Bricault, P; Slobodrian, R J

1985-12-01

A new polarimetry facility has been set up. The four polarimeters used in different geometries are equipped with silicon or carbon analyzers. Extreme care has been taken to cancel out false asymmetries from apparatus misalignments. To that purpose, an automatic beam centering system has been built, two polarimeters are always run simultaneously on both sides of the beam at symmetric angles and geometric means are performed on data reduction. The installation is described in detail and data analysis and calibration runs are presented and discussed.

New Laval facility for polarization measurements

Energy Technology Data Exchange (ETDEWEB)

Pouliot, J; Roy, R; Bricault, P; Slobodrian, R J

1985-12-01

A new polarimetry facility has been set up. The four polarimeters used in different geometries are equipped with silicon or carbon analyzers. Extreme care has been taken to cancel out false asymmetries from apparatus misalignments. To that purpose, an automatic beam centering system has been built, two polarimeters are always run simultaneously on both sides of the beam at symmetric angles and geometric means are performed on data reduction. The installation is described in detail and data analysis and calibration runs are presented and discussed. (orig.).

"Keisri hull" on viimast korda laval

Index Scriptorium Estoniae

2010-01-01

Neli hooaega Ugala repertuaaris olnud Jaan Krossi romaani põhjal lavastatud draama "Keisri hull" etendub viimast korda 10. veebruaril. Viimane etendus on pühendatud Jaan Krossi 90. sünniaastapäevale, mis on 19. veebruaril. Lavastajad Peeter Tammearu ja Jaak Allik. Peaosas Peeter Tammearu

Linnateater toob lavale kuus uut etendust

Index Scriptorium Estoniae

2007-01-01

Tallinna Linnateatri hooaja avas William Shakespeare'i "Eksituste komöödia", mille lavastamisel tegid koostöö Elmo Nüganen ja Stephen Harper Londonist. Ka teistest teatri uue hooaja etendustest tutvustavalt

Striptiisi sünd Vanemuise laval

Index Scriptorium Estoniae

2001-01-01

2. dets. esietendub Vanemuises Ameerika vodevillistaari ja striptiisikuninganna Rose Louise Hovicki memuaaridel põhinev muusikal "Gypsy", lavastaja Mare Tommingas, osades Silvi Vrait ja Helena Merzin

Laval ja põrandal / Mart Siimer

Index Scriptorium Estoniae

Siimer, Mart

1999-01-01

23. augustil Estonia kontserdisaalis toimunud kammerkontserdist "Lootuste lõppematus". Kavas M. Tally "Kaks vaadet merele", T. Trassi "Psalmid" ja T. Tulevi "Sin otra luz". 25. augustil Estonia kontserdisaalis toimunud Birmingami SO kontserdist

ERKI moesõu toob lavale beebid

Index Scriptorium Estoniae

2007-01-01

13.01.2007 toimub Tallinnas Salme kultuurikeskuses moeetendus "Beebibissness ruulib!". Osaleb rootslane Daniel Ivarsson. Londonis tegutsev Piret Paal ja taanlane Anders Henk näitavad second hand riietest disainitud kollektsiooni

Keeleuuendusest sündis diplomilavastus / Anu Lamp

Index Scriptorium Estoniae

Lamp, Anu, 1958-

2006-01-01

24. märtsil esietendus teatris NO99 lavakunstikooli 22. lennu viimane diplomilavastus "Keeleuuenduse lõpmatu kurv". Lavastaja Anu Lamp räägib, kuidas sündis ja kuidas materjal Johannes Aaviku keeleuuendusest lavale jõudis

Muusika : Läti lavastaja alustas Vanemuises "Madame Butterfly" proove / Alo Põldmäe

Index Scriptorium Estoniae

Põldmäe, Alo, 1945-

2004-01-01

Lühidalt muusikasündmustest Eestis ja eesti muusikute tegemistest mujal maailmas. Vanemuine toob lavale kolm maailmakuulsat muusikali. Konverents Eesti ja Soome muusikasuhete teemal. Paavo Järvi Deutsche Kammerphilarmonie ees. Arvo Pärt ja Tõnu Kaljuste Torinos

The Fall mõjub igale inimesele. Black Lips : raju lillepunk Ameerikast. Fujiya & Miyagi krautrokkarid

Index Scriptorium Estoniae

2007-01-01

Järvakandis toimuva festivali "Rabarock" JÄGER laval 14. juunil esinevatest ansamblitest: inglise post-punk bändist The Fall, ameerika garage-pungibändist Black Lips ja elektroonilist krautrokki viljelevast inglise bändist Fujiya & Miyagi

Helsingis tuleb Puccini nädal

Index Scriptorium Estoniae

2001-01-01

Soome Rahvusooper toob !4.-21. jaanuarini 2002 Helsingis lavale G. Puccini ooperid "Tosca", "Boheem", "Tütarlaps Kuldsest L äänest", "Madame Butterfly" ja 18. jaanuaril esietenduva "La Rondine". Lõppeva aasta novembris lavastati Haydni ooper "Orlando Paladino"

Kuusalus on kaks näitetruppi

Index Scriptorium Estoniae

1999-01-01

Kuusalu rahvamaja näitering tõi lavale J. Patricku näidendi "Kummaline missis Savage". Lav. Vendo Peebo Kuusalu näitemänguselts esietendas I. Bresnani ""Hamleti" lavastamine Alamkolka külas". Lav. Saima Merivoo

Dovlatov v Russkom teatre / Jelena Skulskaja ; interv. Dina Treial

Index Scriptorium Estoniae

Skulskaja, Jelena, 1950-

2007-01-01

14. nov. esietendub Vene Teatri väikesel laval "Suur inimene väikeses linnas" Sergei Dovlatovi teemade ja variatsioonidega. Lavaseade ja luuletused kirjutanud Jelena Skulskaja, lavastanud Eduard Toman. Autor endast, oma näidendist ja lavastusest

Võrratu Vint / Vaike Rannu ; fotod: V. Rannu

Index Scriptorium Estoniae

Rannu, Vaike

2005-01-01

lugemisteater "Ilutuli" tõi 28. oktoobril 2005 Tartu College´s lavale Toomas Vindi "Tantsud Mozarti saatel". Lavastaja Aarne H. Vahtra, valgus Vaado Sarapuu, muusika Armas Maiste. Kunstinäitusel olid väljas Eva Oja maalid