photomultiplier tube

CERN Multimedia

A device to convert light into an electric signal (the name is often abbreviated to PM). Photomultipliers are used in all detectors based on scintillating material (i.e. based on large numbers of fibres which produce scintillation light at the passage of a charged particle). A photomultiplier consists of 3 main parts: firstly, a photocathode where photons are converted into electrons by the photoelectric effect; secondly, a multiplier chain consisting of a serie of dynodes which multiply the number of electron; finally, an anode, which collects the resulting current.

photomultiplier tube

CERN Multimedia

Philips. 150AVP. A device to convert light into an electric signal (the name is often abbreviated to PM). Photomultipliers are used in all detectors based on scintillating material (i.e. based on large numbers of fibres which produce scintillation light at the passage of a charged particle). A photomultiplier consists of 3 main parts: firstly, a photocathode where photons are converted into electrons by the photoelectric effect; secondly, a multiplier chain consisting of a serie of dynodes which multiply the number of electron; finally, an anode, which collects the resulting current.

Windows Azure

CERN Document Server

Johnson, Bruce; Chambers, James; Garber, Danny; Malik, Jamal; Fazio, Adam

2013-01-01

A collection of five must-have Azure titles, from some of the biggest names in the field Available individually, but at a discounted rate for the collection, this bundle of five e-books covers key developer and IT topics of Windows Azure, including ASP.NET, mobile services, web sites, data storage, and the hybrid cloud. A host of Microsoft employees and MPVs come together to cover the biggest challenges that professionals face when working with Windows Azure. The e-books included are as follows: Windows Azure and ASP.NET MVC MigrationWindows Azure Mobile ServicesWindows Azure Web SitesWindows

Hybrid window layer for photovoltaic cells

Science.gov (United States)

Deng, Xunming

2010-02-23

A novel photovoltaic solar cell and method of making the same are disclosed. The solar cell includes: at least one absorber layer which could either be a lightly doped layer or an undoped layer, and at least a doped window-layers which comprise at least two sub-window-layers. The first sub-window-layer, which is next to the absorber-layer, is deposited to form desirable junction with the absorber-layer. The second sub-window-layer, which is next to the first sub-window-layer, but not in direct contact with the absorber-layer, is deposited in order to have transmission higher than the first-sub-window-layer.

Yes-Associated Protein (YAP) Promotes the Nuclear Import of p73

International Nuclear Information System (INIS)

Zhang Heng; Wu Shengnan

2011-01-01

p73 has been identified as a structural and functional homolog of the tumor suppressor p53. However, mechanisms that regulate the localization of p73 have not been fully clarified. The Yes-associated protein (YAP) is a transcriptional coactivator. As a transcriptional coactivator, YAP needs to bind transcription factors to stimulate gene expression. p73 is a reported YAP target transcription factors and YAP has been shown to positively regulate p73 in promoting apoptosis. Previous studies show that p73 interacts with YAP through its PPPY motif, and increases p73 transactivation of apoptotic genes. In this study, we focused on YAP's regulation of the localization of p73. After transient transfection into Rat pheochromocytoma (PC12) cells and Human embryonic kidney 293T cells with GFP-YAP and/or YFP-p73, and incubated for 24 hours expression. p73 was fused to YFP to allow the examination of its subcellular localization. When expressed alone, YFP-p73 was distributed throughout the cell. When coexpressed with YAP, nuclear accumulation of YFP-p73 became evident. We quantitated the effect of YAP on the redistribution of YFP-p73 by counting cells with nuclear-only YFP signal. We found that YAP can influence the subcellular distribution of p73. Altogether, coexpression with YAP affected the subcellular distribution of the p73 protein. Our studies attribute a central role to YAP in regulating p73 accumulation and YAP, at least in part, might promote the nuclear import of p73.

Evolution and virulence contributions of the autotransporter proteins YapJ and YapK of Yersinia pestis CO92 and their homologs in Y. pseudotuberculosis IP32953.

Science.gov (United States)

Lenz, Jonathan D; Temple, Brenda R S; Miller, Virginia L

2012-10-01

Yersinia pestis, the causative agent of plague, evolved from the gastrointestinal pathogen Yersinia pseudotuberculosis. Both species have numerous type Va autotransporters, most of which appear to be highly conserved. In Y. pestis CO92, the autotransporter genes yapK and yapJ share a high level of sequence identity. By comparing yapK and yapJ to three homologous genes in Y. pseudotuberculosis IP32953 (YPTB0365, YPTB3285, and YPTB3286), we show that yapK is conserved in Y. pseudotuberculosis, while yapJ is unique to Y. pestis. All of these autotransporters exhibit >96% identity in the C terminus of the protein and identities ranging from 58 to 72% in their N termini. By extending this analysis to include homologous sequences from numerous Y. pestis and Y. pseudotuberculosis strains, we determined that these autotransporters cluster into a YapK (YPTB3285) class and a YapJ (YPTB3286) class. The YPTB3286-like gene of most Y. pestis strains appears to be inactivated, perhaps in favor of maintaining yapJ. Since autotransporters are important for virulence in many bacterial pathogens, including Y. pestis, any change in autotransporter content should be considered for its impact on virulence. Using established mouse models of Y. pestis infection, we demonstrated that despite the high level of sequence identity, yapK is distinct from yapJ in its contribution to disseminated Y. pestis infection. In addition, a mutant lacking both of these genes exhibits an additive attenuation, suggesting nonredundant roles for yapJ and yapK in systemic Y. pestis infection. However, the deletion of the homologous genes in Y. pseudotuberculosis does not seem to impact the virulence of this organism in orogastric or systemic infection models.

Improved hybrid information filtering based on limited time window

Science.gov (United States)

Song, Wen-Jun; Guo, Qiang; Liu, Jian-Guo

2014-12-01

Adopting the entire collecting information of users, the hybrid information filtering of heat conduction and mass diffusion (HHM) (Zhou et al., 2010) was successfully proposed to solve the apparent diversity-accuracy dilemma. Since the recent behaviors are more effective to capture the users' potential interests, we present an improved hybrid information filtering of adopting the partial recent information. We expand the time window to generate a series of training sets, each of which is treated as known information to predict the future links proven by the testing set. The experimental results on one benchmark dataset Netflix indicate that by only using approximately 31% recent rating records, the accuracy could be improved by an average of 4.22% and the diversity could be improved by 13.74%. In addition, the performance on the dataset MovieLens could be preserved by considering approximately 60% recent records. Furthermore, we find that the improved algorithm is effective to solve the cold-start problem. This work could improve the information filtering performance and shorten the computational time.

Photomultiplier protector for a fluorometer

International Nuclear Information System (INIS)

Priarone, P.; St John, P.A.

1982-01-01

The photometer is adapted for sensing radiation emitted by a chemical sample held in a cuvette received in a first compartment and includes a highly sensitive photomultiplier in a second compartment adjacent the first compartment for detecting fluorescent radiation emitted by the chemical sample and passing through an opening between the compartments. A mechanical protector assembly is provided for protecting the photomultiplier from ambient light and includes a movable light shield movable between a first position blocking the opening and a second position not blocking the opening. A knob is provided for moving the light shield to the first position to protect the photomultiplier from light entering from the first compartment when the first compartment is opened for insertion or removal of a cuvette, and for moving the light shield to the second position not blocking the opening to permit radiation emitted by the chemical sample to impinge upon the photomultiplier in the second compartment. The photometer also includes a mechanical interlocking assembly for ensuring that the first compartment cannot be opened unless the light shield is in the first position to prevent ambient light from entering the second compartment from the first compartment and reaching the photomultiplier

Development of Silicon Photomultipliers and their Applications to GlueX Calorimetry

Energy Technology Data Exchange (ETDEWEB)

Smith, Elton S. [Thomas Jefferson National Accelerator Facility (TJNAF), Newport News, VA (United States)

2016-07-01

The GlueX experiment is a photoproduction experiment in Hall D at Jefferson Lab that is being commissioned for use with the new 12 GeV accelerator. The purpose of the experiment is to search for Hybrid mesons, which are mesons with quark and gluon degrees of freedom. The barrel calorimeter of GlueX is instrumented with 4000 large-area (1.2 x1.2 cm2) silicon photomultipliers (SiPMs). These photon sensors have properties similar to vacuum photomultipliers, but are unaffected by high magnetic fields. In our experiment they operate in magnetic fields exceeding 1T. After extensive tests with a variety of sensors, we chose the S12045(X) custom SiPM arrays manufactured by Hamamatsu Corporation, also known as multi-pixel photon counters (MPPCs). We will give an overview of this new technology as well as the experience gained during two commissioning periods with beam.

Development of silicon photomultipliers and their applications to GlueX calorimetry

Energy Technology Data Exchange (ETDEWEB)

Smith, Elton S., E-mail: elton@jlab.org [Jefferson Lab, Newport News, VA 23606 (United States)

2016-07-07

The GlueX experiment is a photoproduction experiment in Hall D at Jefferson Lab that is being commissioned for use with the new 12 GeV accelerator. The purpose of the experiment is to search for Hybrid mesons, which are mesons with quark and gluon degrees of freedom. The barrel calorimeter of GlueX is instrumented with 4000 large-area (1.2 × 1.2 cm{sup 2}) silicon photomultipliers (SiPMs). These photon sensors have properties similar to vacuum photomultipliers, but are unaffected by high magnetic fields. In our experiment they operate in magnetic fields exceeding 1T. After extensive tests with a variety of sensors, we chose the S12045(X) custom SiPM arrays manufactured by Hamamatsu Corporation, also known as multi-pixel photon counters (MPPCs). We will give an overview of this new technology as well as the experience gained during two commissioning periods with beam.

Preparatory Study of Photomultiplier Tubes of 10-inch and 3-inch Diameter for KM3NeT Underwater Neutrino Telescope

International Nuclear Information System (INIS)

Aiello, S.; Giordano, V.; Leonora, E.

2015-01-01

Large area photomultipliers are widely used in neutrino and astro-particle detectors to measure Cherenkov light in media like water or ice. The key element of these detectors are the so-called 'optical module', which consists of a photodetector enclosed in a transparent pressure-resistant container to protect it and ensure good light transmission. KM3NeT collaboration aims to construct an underwater 'hybrid' neutrino telescope by using two models detection unit. The 'tower' detection unit will be composed of large area 10-inch photomultipliers tube enclosed into 13-inch glass vessel sphere. In the 'string' detection unit instead, the light detector will be the 'digital optical module' (DOM) a glass vessel of 17-inch with 31 photomultipliers of 3- inch diameter looking upwards and downwards. The choice of two different kinds of photomultipliers, obliges us to investigate their main characteristics. Noise pulses at the anode of each photomultiplier strongly affect the performance of the detector. A large study was conducted on noise pulses of large area photomultipliers, considering time and charge distributions of dark pulses, pre-pulses, delayed pulses, and after-pulses. The contribution to noise pulses due to the presence of the external glass vessels was also studied. Moreover the presence of the Earth's magnetic field should modify quantities like gain and transit time spread in photomultipliers and we will deeply investigate on this. (authors)

Optimization of Performance Parameters for Large Area Silicon Photomultipliers

Science.gov (United States)

Janzen, Kathryn

2008-10-01

The goal of the GlueX experiment is to search for exotic hybrid mesons as evidence of gluonic excitations in an effort to better understand confinement. A key component of the GlueX detector is the electromagnetic barrel calorimeter (BCAL) located immediately inside a superconducting solenoid of approximately 2.5T. Because of this arrangement, traditional vacuum photomultiplier tubes (PMTs) which are affected significantly by magnetic fields cannot be used on the BCAL. The use of Silicon photomultipliers (SiPMs) as front-end detectors has been proposed. While the largest SiPMs that have been previously employed by other experiments are 1x1 mm^2, GlueX proposes to use large area SiPMs each composed of 16 - 3x3 mm^2 cells in a 4x4 array. This puts the GlueX collaboration in the unique position of driving the technology for larger area sensors. In this talk I will discuss tests done in Regina regarding performance parameters of prototype SiPM arrays delivered by SensL, a photonics research and development company based in Ireland, as well as sample 1x1 mm^2 and 3x3 mm^2 SiPMs.

Characterization of New-Generation Silicon Photomultipliers for Nuclear Security Applications

Science.gov (United States)

Wonders, Marc A.; Chichester, David L.; Flaska, Marek

2018-01-01

Silicon photomultipliers have received a great deal of interest recently for use in applications spanning a wide variety of fields, including nuclear safeguards and nonproliferation. For nuclear-related applications, the ability of silicon photomultipliers to discriminate neutrons from gamma rays using pulse shape discrimination when coupled with certain organic scintillators is a characteristic of utmost importance. This work reports on progress characterizing the performance of twenty different silicon photomultipliers from five manufacturers with an emphasis on pulse shape discrimination performance and timing. Results are presented on pulse shape discrimination performance as a function of overvoltage for 6-mm x 6-mm silicon photomultipliers, and the time response to stilbene is characterized for silicon photomultipliers of three different sizes. Finally, comparison with a photomultiplier tube shows that some new-generation silicon photomultipliers can perform as well as photomultiplier tubes in neutron-gamma ray discrimination.

YAP Inhibition Restores Hepatocyte Differentiation in Advanced HCC, Leading to Tumor Regression

Directory of Open Access Journals (Sweden)

Julien Fitamant

2015-03-01

Full Text Available Defective Hippo/YAP signaling in the liver results in tissue overgrowth and development of hepatocellular carcinoma (HCC. Here, we uncover mechanisms of YAP-mediated hepatocyte reprogramming and HCC pathogenesis. YAP functions as a rheostat in maintaining metabolic specialization, differentiation, and quiescence within the hepatocyte compartment. Increased or decreased YAP activity reprograms subsets of hepatocytes to different fates associated with deregulation of the HNF4A, CTNNB1, and E2F transcriptional programs that control hepatocyte quiescence and differentiation. Importantly, treatment with small interfering RNA-lipid nanoparticles (siRNA-LNPs targeting YAP restores hepatocyte differentiation and causes pronounced tumor regression in a genetically engineered mouse HCC model. Furthermore, YAP targets are enriched in an aggressive human HCC subtype characterized by a proliferative signature and absence of CTNNB1 mutations. Thus, our work reveals Hippo signaling as a key regulator of the positional identity of hepatocytes, supports targeting of YAP using siRNA-LNPs as a paradigm of differentiation-based therapy, and identifies an HCC subtype that is potentially responsive to this approach.

Characterization of New-Generation Silicon Photomultipliers for Nuclear Security Applications

Directory of Open Access Journals (Sweden)

Wonders Marc A.

2018-01-01

Full Text Available Silicon photomultipliers have received a great deal of interest recently for use in applications spanning a wide variety of fields, including nuclear safeguards and nonproliferation. For nuclear-related applications, the ability of silicon photomultipliers to discriminate neutrons from gamma rays using pulse shape discrimination when coupled with certain organic scintillators is a characteristic of utmost importance. This work reports on progress characterizing the performance of twenty different silicon photomultipliers from five manufacturers with an emphasis on pulse shape discrimination performance and timing. Results are presented on pulse shape discrimination performance as a function of overvoltage for 6-mm x 6-mm silicon photomultipliers, and the time response to stilbene is characterized for silicon photomultipliers of three different sizes. Finally, comparison with a photomultiplier tube shows that some new-generation silicon photomultipliers can perform as well as photomultiplier tubes in neutron-gamma ray discrimination.

The Hippo-YAP Pathway Regulates 3D Organ Formation and Homeostasis.

Science.gov (United States)

Ishihara, Erika; Nishina, Hiroshi

2018-04-17

The vertebrate body shape is formed by the specific sizes and shapes of its resident tissues and organs, whose alignments are essential for proper functioning. To maintain tissue and organ shape, and thereby function, it is necessary to remove senescent, transformed, and/or damaged cells, which impair function and can lead to tumorigenesis. However, the molecular mechanisms underlying three-dimensional (3D) organ formation and homeostasis are not fully clear. Yes-associated protein (YAP) is a transcriptional co-activator that is involved in organ size control and tumorigenesis. Recently, we reported that YAP is essential for proper 3D body shape through regulation of cell tension by using a unique medaka fish mutant, hirame ( hir ). In Madin–Darby canine kidney (MDCK) epithelial cells, active YAP-transformed cells are eliminated apically when surrounded by normal cells. Furthermore, in a mosaic mouse model, active YAP-expressing damaged hepatocytes undergo apoptosis and are eliminated from the liver. Thus, YAP functions in quantitative and quality control in organogenesis. In this review, we describe the various roles of YAP in vertebrates, including in the initiation of liver cancer.

YAP expression in normal and neoplastic breast tissue: an immunohistochemical study.

Science.gov (United States)

Jaramillo-Rodríguez, Yolanda; Cerda-Flores, Ricardo M; Ruiz-Ramos, Ruben; López-Márquez, Francisco C; Calderón-Garcidueñas, Ana Laura

2014-04-01

Yes-associated protein (YAP) is a transcriptional factor involved in normal cell proliferation, apoptosis and carcinogenesis; however, its contribution to breast cancer (BC) is still controversial. We undertook this study to compare the expression of YAP by immunohistochemistry (IHC) in normal breast tissue of women without breast cancer (BC) (controls), non-neoplastic breast tissue in women with cancer (internal controls) and in four different subtypes of invasive ductal carcinoma. There were 17 controls and 105 tumor cases (53 luminal A, 15 luminal B, 20 overexpression of HER2 and 17 triple negative cases) studied by IHC. Statistical analysis included χ(2) for linear trend (Extended Mantel-Haenszel). There were 40% of internal controls that showed expression of YAP in myoepithelial cells, whereas in controls expression was 100%. In controls, 3/17 (17.6%) showed cytoplasmic staining in luminal cells. There was a significant difference in nuclear expression between the ductal BC subtypes. Luminal A had 4% of positive cases with <10% of cells affected in each case; in contrast, there were 17-20% of positive cases in the other groups with 50% or more of stained cells. YAP expression in stromal cells was not observed in controls or in triple-negative cases, and luminal B pattern had the highest YAP nuclear expression (20%). YAP showed decreased expression in tumor cells compared with normal breast tissue. These findings are consistent with a role of YAP as a suppressor gene in BC and show differences in YAP expression in different patterns of ductal BC. Copyright © 2014 IMSS. Published by Elsevier Inc. All rights reserved.

Silicon photomultiplier as a detector of Cherenkov photons

International Nuclear Information System (INIS)

Korpar, S.; Dolenec, R.; Hara, K.; Iijima, T.; Krizan, P.; Mazuka, Y.; Pestotnik, R.; Stanovnik, A.; Yamaoka, M.

2008-01-01

A novel photon detector-i.e. the silicon photomultiplier-whose main advantage over conventional photomultiplier tubes is the operation in high magnetic fields, has been tested as a photon detector in a proximity focusing RICH with aerogel radiator. This type of RICH counter is proposed for the upgrade of the Belle detector at the KEK B-factory. Recently produced silicon photomultipliers show less noise and have larger size, which are important issues for a large area photon detector. We measured the single photon pulse height distribution, the timing resolution and the position sensitivity for different silicon photomultipliers (Hamamatsu MPPC HC025, HC050, and HC100). The silicon photomultipliers were then used to detect Cherenkov photons emitted by cosmic ray particles in a proximity focusing aerogel RICH. Various light guides were investigated in order to increase the detection efficiency

Yap is required for ependymal integrity and is suppressed in LPA-induced hydrocephalus

Science.gov (United States)

Park, Raehee; Moon, Uk Yeol; Park, Jun Young; Hughes, Lucinda J.; Johnson, Randy L.; Cho, Seo-Hee; Kim, Seonhee

2016-01-01

Timely generation and normal maturation of ependymal cells along the aqueduct are critical for preventing physical blockage between the third and fourth ventricles and the development of fetal non-communicating hydrocephalus. Our study identifies Yap, the downstream effector of the evolutionarily conserved Hippo pathway, as a central regulator for generating developmentally controlled ependymal cells along the ventricular lining of the aqueduct. Yap function is necessary for proper proliferation of progenitors and apical attachment of ependymal precursor cells. Importantly, an injury signal initiated by lysophosphatidic acid (LPA), an upstream regulator of Yap that can cause fetal haemorrhagic hydrocephalus, deregulates Yap in the developing aqueduct. LPA exposure leads to the loss of N-cadherin concentrations at the apical endfeet, which can be partially restored by forced Yap expression and more efficiently by phosphomimetic Yap. These results reveal a novel function of Yap in retaining tissue junctions during normal development and after fetal brain injury. PMID:26754915

Scintillation probe with photomultiplier tube saturation indicator

International Nuclear Information System (INIS)

Ruch, J.F.; Urban, D.J.

1996-01-01

A photomultiplier tube saturation indicator is formed by supplying a supplemental light source, typically an light emitting diode (LED), adjacent to the photomultiplier tube. A switch allows the light source to be activated. The light is forwarded to the photomultiplier tube by an optical fiber. If the probe is properly light tight, then a meter attached to the indicator will register the light from the LED. If the probe is no longer light tight, and the saturation indicator is saturated, no signal will be registered when the LED is activated. 2 figs

Precise analysis of the metal package photomultiplier single photoelectron spectra

International Nuclear Information System (INIS)

Chirikov-Zorin, I.E.; Fedorko, I.; Sykora, I.; Tokar, S.; Menzione, A.

2000-01-01

A deconvolution method based on a sophisticated photomultiplier response function was used to analyse the compact metal package photomultiplier spectra taken in single photoelectron mode. The spectra taken by Hamamtsu R5600 and R5900 photomultipliers have been analysed. The detailed analysis shows that the method appropriately describes the process of charge multiplication in these photomultipliers in a wide range of working regimes and the deconvoluted parameters are established with about 1% accuracy. The method can be used for a detailed analysis of photomultiplier noise and for calibration purposes

Force Triggers YAP Nuclear Entry by Regulating Transport across Nuclear Pores.

Science.gov (United States)

Elosegui-Artola, Alberto; Andreu, Ion; Beedle, Amy E M; Lezamiz, Ainhoa; Uroz, Marina; Kosmalska, Anita J; Oria, Roger; Kechagia, Jenny Z; Rico-Lastres, Palma; Le Roux, Anabel-Lise; Shanahan, Catherine M; Trepat, Xavier; Navajas, Daniel; Garcia-Manyes, Sergi; Roca-Cusachs, Pere

2017-11-30

YAP is a mechanosensitive transcriptional activator with a critical role in cancer, regeneration, and organ size control. Here, we show that force applied to the nucleus directly drives YAP nuclear translocation by decreasing the mechanical restriction of nuclear pores to molecular transport. Exposure to a stiff environment leads cells to establish a mechanical connection between the nucleus and the cytoskeleton, allowing forces exerted through focal adhesions to reach the nucleus. Force transmission then leads to nuclear flattening, which stretches nuclear pores, reduces their mechanical resistance to molecular transport, and increases YAP nuclear import. The restriction to transport is further regulated by the mechanical stability of the transported protein, which determines both active nuclear transport of YAP and passive transport of small proteins. Our results unveil a mechanosensing mechanism mediated directly by nuclear pores, demonstrated for YAP but with potential general applicability in transcriptional regulation. Copyright © 2017 Elsevier Inc. All rights reserved.

A Novel Notch-YAP Circuit Drives Stemness and Tumorigenesis in Embryonal Rhabdomyosarcoma.

Science.gov (United States)

Slemmons, Katherine K; Crose, Lisa E S; Riedel, Stefan; Sushnitha, Manuela; Belyea, Brian; Linardic, Corinne M

2017-12-01

Rhabdomyosarcoma (RMS), a cancer characterized by skeletal muscle features, is the most common soft-tissue sarcoma of childhood. While low- and intermediate-risk groups have seen improved outcomes, high-risk patients still face a 5-year survival rate of statistic that has not changed in over 40 years. Understanding the biologic underpinnings of RMS is critical. The developmental pathways of Notch and YAP have been identified as potent but independent oncogenic signals that support the embryonal variant of RMS (eRMS). Here, the cross-talk between these pathways and the impact on eRMS tumorigenesis is reported. Using human eRMS cells grown as three-dimensional (3D) rhabdospheres, which enriches in stem cells, it was found that Notch signaling transcriptionally upregulates YAP1 gene expression and YAP activity. Reciprocally, YAP transcriptionally upregulates the Notch ligand genes JAG1 and DLL1 and the core Notch transcription factor RBPJ This bidirectional circuit boosts expression of key stem cell genes, including SOX2 , which is functionally required for eRMS spheres. Silencing this circuit for therapeutic purposes may be challenging, because the inhibition of one node (e.g., pharmacologic Notch blockade) can be rescued by upregulation of another (constitutive YAP expression). Instead, dual inhibition of Notch and YAP is necessary. Finally, supporting the existence of this circuit beyond a model system, nuclear Notch and YAP protein expression are correlated in human eRMS tumors, and YAP suppression in vivo decreases Notch signaling and SOX2 expression. Implications: This study identifies a novel oncogenic signaling circuit driving eRMS stemness and tumorigenesis, and provides evidence and rationale for combination therapies co-targeting Notch and YAP. Mol Cancer Res; 15(12); 1777-91. ©2017 AACR . ©2017 American Association for Cancer Research.

Nuclear localization of the transcriptional coactivator YAP is associated with invasive lobular breast cancer.

Science.gov (United States)

Vlug, Eva J; van de Ven, Robert A H; Vermeulen, Jeroen F; Bult, Peter; van Diest, Paul J; Derksen, Patrick W B

2013-10-01

Yes Associated Protein (YAP) has been implicated in the control of organ size by regulating cell proliferation and survival. YAP is a transcriptional coactivator that controls cellular responses through interaction with TEAD transcription factors in the nucleus, while its transcriptional functions are inhibited by phosphorylation-dependent translocation to the cytosol. YAP overexpression has been associated with different types of cancer, such as lung, skin, prostate, ovary and liver cancer. Recently, YAP was linked to E-cadherin-dependent regulation of contact inhibition in breast cancer cells. In this study we examined YAP protein expression and cellular localization in 237 cases of human invasive breast cancer by immunohistochemistry and related its expression to clinicopathological features and E-cadherin expression. We observed that invasive lobular carcinoma is characterized by higher expression levels of both nuclear and cytosolic YAP (p invasive breast cancer. We observed that high nuclear and cytosolic YAP expression are associated with the E-cadherin deficient breast cancer subtype ILC (p cancers and conditional mouse models of human lobular breast cancer. Since our data indicate that nuclear YAP localization is more common in breast cancers lacking functional adherens junctions, it suggests that YAP-mediated transcription may be involved in the development and progression of invasive lobular breast cancer.

A hairpin within YAP mRNA 3′UTR functions in regulation at post-transcription level

Energy Technology Data Exchange (ETDEWEB)

Gao, Yuen; Wang, Yuan; Feng, Jinyan; Feng, Guoxing; Zheng, Minying; Yang, Zhe; Xiao, Zelin; Lu, Zhanping [State Key Laboratory of Medicinal Chemical Biology, Department of Cancer Research, College of Life Sciences, Nankai University, Tianjin 300071 (China); Ye, Lihong [State Key Laboratory of Medicinal Chemical Biology, Department of Biochemistry, College of Life Sciences, Nankai University, Tianjin 300071 (China); Zhang, Xiaodong, E-mail: zhangxd@nankai.edu.cn [State Key Laboratory of Medicinal Chemical Biology, Department of Cancer Research, College of Life Sciences, Nankai University, Tianjin 300071 (China)

2015-04-03

The central dogma of gene expression is that DNA is transcribed into messenger RNAs, which in turn serve as the template for protein synthesis. Recently, it has been reported that mRNAs display regulatory roles that rely on their ability to compete for microRNA binding, independent of their protein-coding function. However, the regulatory mechanism of mRNAs remains poorly understood. Here, we report that a hairpin within YAP mRNA 3′untranslated region (3′UTR) functions in regulation at post-transcription level through generating endogenous siRNAs (esiRNAs). Bioinformatics analysis for secondary structure showed that YAP mRNA displayed a hairpin structure (termed standard hairpin, S-hairpin) within its 3′UTR. Surprisingly, we observed that the overexpression of S-hairpin derived from YAP 3′UTR (YAP-sh) increased the luciferase reporter activities of transcriptional factor NF-κB and AP-1 in 293T cells. Moreover, we identified that a fragment from YAP-sh, an esiRNA, was able to target mRNA 3′UTR of NF2 (a member of Hippo-signaling pathway) and YAP mRNA 3′UTR itself in hepatoma cells. Thus, we conclude that the YAP-sh within YAP mRNA 3′UTR may serve as a novel regulatory element, which functions in regulation at post-transcription level. Our finding provides new insights into the mechanism of mRNAs in regulatory function. - Highlights: • An S-hairpin within YAP mRNA 3′UTR possesses regulatory function. • YAP-sh acts as a regulatory element for YAP at post-transcription level. • YAP-sh-3p20, an esiRNA derived from YAP-sh, targets mRNAs of YAP and NF2. • YAP-sh-3p20 depresses the proliferation of HepG2 cells in vitro.

A hairpin within YAP mRNA 3′UTR functions in regulation at post-transcription level

International Nuclear Information System (INIS)

Gao, Yuen; Wang, Yuan; Feng, Jinyan; Feng, Guoxing; Zheng, Minying; Yang, Zhe; Xiao, Zelin; Lu, Zhanping; Ye, Lihong; Zhang, Xiaodong

2015-01-01

The central dogma of gene expression is that DNA is transcribed into messenger RNAs, which in turn serve as the template for protein synthesis. Recently, it has been reported that mRNAs display regulatory roles that rely on their ability to compete for microRNA binding, independent of their protein-coding function. However, the regulatory mechanism of mRNAs remains poorly understood. Here, we report that a hairpin within YAP mRNA 3′untranslated region (3′UTR) functions in regulation at post-transcription level through generating endogenous siRNAs (esiRNAs). Bioinformatics analysis for secondary structure showed that YAP mRNA displayed a hairpin structure (termed standard hairpin, S-hairpin) within its 3′UTR. Surprisingly, we observed that the overexpression of S-hairpin derived from YAP 3′UTR (YAP-sh) increased the luciferase reporter activities of transcriptional factor NF-κB and AP-1 in 293T cells. Moreover, we identified that a fragment from YAP-sh, an esiRNA, was able to target mRNA 3′UTR of NF2 (a member of Hippo-signaling pathway) and YAP mRNA 3′UTR itself in hepatoma cells. Thus, we conclude that the YAP-sh within YAP mRNA 3′UTR may serve as a novel regulatory element, which functions in regulation at post-transcription level. Our finding provides new insights into the mechanism of mRNAs in regulatory function. - Highlights: • An S-hairpin within YAP mRNA 3′UTR possesses regulatory function. • YAP-sh acts as a regulatory element for YAP at post-transcription level. • YAP-sh-3p20, an esiRNA derived from YAP-sh, targets mRNAs of YAP and NF2. • YAP-sh-3p20 depresses the proliferation of HepG2 cells in vitro

Energy Stress Regulates Hippo-YAP Signaling Involving AMPK-Mediated Regulation of Angiomotin-like 1 Protein

Directory of Open Access Journals (Sweden)

Michael DeRan

2014-10-01

Full Text Available Hippo signaling is a tumor-suppressor pathway involved in organ size control and tumorigenesis through the inhibition of YAP and TAZ. Here, we show that energy stress induces YAP cytoplasmic retention and S127 phosphorylation and inhibits YAP transcriptional activity and YAP-dependent transformation. These effects require the central metabolic sensor AMP-activated protein kinase (AMPK and the upstream Hippo pathway components Lats1/Lats2 and angiomotin-like 1 (AMOTL1. Furthermore, we show that AMPK directly phosphorylates S793 of AMOTL1. AMPK activation stabilizes and increases AMOTL1 steady-state protein levels, contributing to YAP inhibition. The phosphorylation-deficient S793Ala mutant of AMOTL1 showed a shorter half-life and conferred resistance to energy-stress-induced YAP inhibition. Our findings link energy sensing to the Hippo-YAP pathway and suggest that YAP may integrate spatial (contact inhibition, mechanical, and metabolic signals to control cellular proliferation and survival.

First results of systematic studies done with silicon photomultipliers

International Nuclear Information System (INIS)

Bosio, C.; Gentile, S.; Kuznetsova, E.; Meddi, F.

2008-01-01

Multicell avalanche photodiode structure operated in Geiger mode usually referred as silicon photomultiplier is a new intensively developing technology for photon detection. Insensitivity to magnetic fields, low operation voltage and small size make silicon photomultipliers very attractive for high-energy physics, astrophysics and medical applications. The presented results are obtained during the first steps taken in order to develop a setup and measurement procedures which allow to compare properties of diverse samples of silicon photomultipliers available on market. The response to low-intensity light was studied for silicon photomultipliers produced by CPTA (Russia), Hamamatsu (Japan), ITC-irst (Italy) and SensL (Ireland).

YAP/TAZ enhance mammalian embryonic neural stem cell characteristics in a Tead-dependent manner

Energy Technology Data Exchange (ETDEWEB)

Han, Dasol; Byun, Sung-Hyun; Park, Soojeong; Kim, Juwan; Kim, Inhee; Ha, Soobong; Kwon, Mookwang; Yoon, Keejung, E-mail: keejung@skku.edu

2015-02-27

Mammalian brain development is regulated by multiple signaling pathways controlling cell proliferation, migration and differentiation. Here we show that YAP/TAZ enhance embryonic neural stem cell characteristics in a cell autonomous fashion using diverse experimental approaches. Introduction of retroviral vectors expressing YAP or TAZ into the mouse embryonic brain induced cell localization in the ventricular zone (VZ), which is the embryonic neural stem cell niche. This change in cell distribution in the cortical layer is due to the increased stemness of infected cells; YAP-expressing cells were colabeled with Sox2, a neural stem cell marker, and YAP/TAZ increased the frequency and size of neurospheres, indicating enhanced self-renewal- and proliferative ability of neural stem cells. These effects appear to be TEA domain family transcription factor (Tead)–dependent; a Tead binding-defective YAP mutant lost the ability to promote neural stem cell characteristics. Consistently, in utero gene transfer of a constitutively active form of Tead2 (Tead2-VP16) recapitulated all the features of YAP/TAZ overexpression, and dominant negative Tead2-EnR resulted in marked cell exit from the VZ toward outer cortical layers. Taken together, these results indicate that the Tead-dependent YAP/TAZ signaling pathway plays important roles in neural stem cell maintenance by enhancing stemness of neural stem cells during mammalian brain development. - Highlights: • Roles of YAP and Tead in vivo during mammalian brain development are clarified. • Expression of YAP promotes embryonic neural stem cell characteristics in vivo in a cell autonomous fashion. • Enhancement of neural stem cell characteristics by YAP depends on Tead. • Transcriptionally active form of Tead alone can recapitulate the effects of YAP. • Transcriptionally repressive form of Tead severely reduces stem cell characteristics.

YAP/TAZ enhance mammalian embryonic neural stem cell characteristics in a Tead-dependent manner

International Nuclear Information System (INIS)

Han, Dasol; Byun, Sung-Hyun; Park, Soojeong; Kim, Juwan; Kim, Inhee; Ha, Soobong; Kwon, Mookwang; Yoon, Keejung

2015-01-01

Mammalian brain development is regulated by multiple signaling pathways controlling cell proliferation, migration and differentiation. Here we show that YAP/TAZ enhance embryonic neural stem cell characteristics in a cell autonomous fashion using diverse experimental approaches. Introduction of retroviral vectors expressing YAP or TAZ into the mouse embryonic brain induced cell localization in the ventricular zone (VZ), which is the embryonic neural stem cell niche. This change in cell distribution in the cortical layer is due to the increased stemness of infected cells; YAP-expressing cells were colabeled with Sox2, a neural stem cell marker, and YAP/TAZ increased the frequency and size of neurospheres, indicating enhanced self-renewal- and proliferative ability of neural stem cells. These effects appear to be TEA domain family transcription factor (Tead)–dependent; a Tead binding-defective YAP mutant lost the ability to promote neural stem cell characteristics. Consistently, in utero gene transfer of a constitutively active form of Tead2 (Tead2-VP16) recapitulated all the features of YAP/TAZ overexpression, and dominant negative Tead2-EnR resulted in marked cell exit from the VZ toward outer cortical layers. Taken together, these results indicate that the Tead-dependent YAP/TAZ signaling pathway plays important roles in neural stem cell maintenance by enhancing stemness of neural stem cells during mammalian brain development. - Highlights: • Roles of YAP and Tead in vivo during mammalian brain development are clarified. • Expression of YAP promotes embryonic neural stem cell characteristics in vivo in a cell autonomous fashion. • Enhancement of neural stem cell characteristics by YAP depends on Tead. • Transcriptionally active form of Tead alone can recapitulate the effects of YAP. • Transcriptionally repressive form of Tead severely reduces stem cell characteristics

Study of Various Photomultiplier Tubes for Window Events: Upgrade R\\&D for CMS Hadron Forward Calorimeters

CERN Document Server

Bilki, Burak

2010-01-01

The PMTs of the CMS Hadron Forward calorimeter were found to generate a large amount of signal when their windows were traversed by energetic charged particles. This signal, which is due to \\u{C}erenkov light production at the PMT window, could interfere with the calorimeter signal and mislead the measurements. In order to find a viable solution to this problem, the response of different types of PMTs to muons traversing their windows at different orientations is measured at the H2 beam-line at CERN. Certain kinds of PMTs with thinner windows show significantly lower response to direct muon incidence. For one specific type -the four anode PMT- a simple and powerful algorithm to identify such events and recover the PMT signal using the signals of the quadrants without window hits is also presented. For the measurement of PMT responses to \\u{C}erenkov light, the Hadron Forward calorimeter signal was mimicked by two different setups in electron beams and the PMT performances were compared with each other. Superi...

Yes-associated protein homolog, YAP-1, is involved in the thermotolerance and aging in the nematode Caenorhabditis elegans

Energy Technology Data Exchange (ETDEWEB)

Iwasa, Hiroaki [Department of Medical Biochemistry, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo 113-8519 (Japan); Maimaiti, Sainawaer [Department of Medical Biochemistry, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo 113-8519 (Japan); Department of Psychotherapy, The Fourth People' s Hospital of Urumqi, Urumqi 830000 (China); Kuroyanagi, Hidehito [Laboratory of Gene Expression, Graduate School of Biomedical Science, Tokyo Medical and Dental University, Tokyo 113-8519 (Japan); Kawano, Shodai; Inami, Kazutoshi; Timalsina, Shikshya; Ikeda, Mitsunobu; Nakagawa, Kentaro [Department of Medical Biochemistry, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo 113-8519 (Japan); Hata, Yutaka, E-mail: yuhammch@tmd.ac.jp [Department of Medical Biochemistry, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo 113-8519 (Japan)

2013-04-15

The mammalian Hippo pathway comprises mammalian Ste20-like kinases (MST1/2) and large tumor suppressor kinases (LATS1/2). LATS1/2, which are activated by MST1/2, phosphorylate a transcriptional co-activator, yes-associated protein (YAP), and induce the recruitment of YAP by 14-3-3 to cytoplasm, so that the TEAD-dependent gene transcriptions are turned off. Although the core components of the Hippo pathway are well conserved in metazoans, it has been discussed that Caenorhabditis elegans lacks YAP ortholog, we found that F13E6.4 gene encodes a protein that shows sequence similarities to YAP in the N-terminal TEAD-binding domain and in the WW domain. We designated this gene as yap-1. YAP-1 is widely expressed in various cells such as epithelial cells, muscles, hypodermal cells, gonadal sheath cells, spermatheca, and hypodermal cells. YAP-1 is distributed in cytoplasm and nuclei. wts-1 (LATS ortholog) and ftt-2 (14-3-3 ortholog) knockdowns cause nuclear accumulation of YAP-1, supporting that the subcellular localization of YAP-1 is regulated in a similar way as that of YAP. Heat shock also causes the nuclear accumulation of YAP-1 but after heat shock, YAP-1 translocates to cytoplasm. Knockdowns of DAF-21 (HSP90 ortholog) and HSF-1block the nuclear export of YAP-1 during this recovery. YAP-1 overexpression is beneficial for thermotolerance, whereas YAP-1 hyperactivity induced by wts-1 and ftt-2 knockdowns is deleterious on thermal response and yap-1 deficiency promotes health aging. In short, YAP-1 partially shares basal characters with mammalian YAP and plays a role in thermal stress response and healthy aging. - Highlights: ► We named Caenorhabditis elegans F13E6.4 gene yap-1 as a putative YAP homolog. ► The localization of YAP-1 is regulated by WTS-1 and FTT-2. ► YAP-1 is involved in healthy aging and thermosensitivity.

Substitution of photomultiplier tubes by photodiodes

International Nuclear Information System (INIS)

Teixeira, D.L.

1990-04-01

The application of Si semiconductors, either of the conventional or the avalanche type, as light amplifiers in radiation detection, has been studied aiming the substitution of photomultiplier (PM) tubes by photodiodes. The objective of this work is to compare the response of photodiodes and PM tubes when coupled to scintillation crystals. A Hamamatsu Si photodiode, model S 1337-66 B Q, was coupled to a Harshaw NaI (TI) scintillation crystal of window diameter equal to 25,4 mm. Its performance was evaluated by specially designed associated electronics, compatible with the photodiode characteristics. X-ray beams from 30 to 111 KeV were used to determine the response and the repeatability of the scintillator-photodiode and the scintillator-PM tube systems. The repeatability was found to be within 0,27% for the photodiode and 0,57% for the PM tube. This work confirmed that photodiodes can be used as light amplifiers, provided their characteristics, such as light spectrum response, are considered. It also shows that further studies are necessary in order to identify the applications in radiation detection where PM tubes might be replaced by photodiodes. (author)

Efficient 2-μm Tm:YAP Q-switched and CW lasers

Science.gov (United States)

Hays, A. D.; Cole, Brian; King, Vernon; Goldberg, Lew

2018-02-01

Highly efficient, diode pumped Tm:YAP lasers generating emission in the 1.85-1.94 μm range are demonstrated and characterized. Laser optical efficiencies of 51% and 45%, and electrical efficiencies of 31% and 25% are achieved under CW and Q-switched operation, respectively. Laser performance was characterized for maximum average powers up to 20W with various cavity configurations, all using an intra-cavity lens to compensate for thermal lensing in the Tm:YAP crystal. Q-switched lasers incorportating a Cr:ZnS saturable absorber (SA), resonant mechanical mirror scanner, or acousto-optic modulator were characterized. To enable higher average output powers, measurements of the thermal lens were conducted for the Tm:YAP crystal as a function of pump power and were compared to values predicted by a finiteelement- analysis (FEA) thermal-optical model of the Tm:YAP crystal. A resonator model is developed to incorporate this calculated thermal lens and its effect on laser performance. This paper will address approaches for improving the performance of Tm:YAP lasers, and means for achieving increased average output powers while maintaining high optical efficiency for both SA and mechanical Q-switching.

Photomultiplier tubes for Low Level Cerenkov Detectors

Energy Technology Data Exchange (ETDEWEB)

Strindehag, O

1965-03-15

Tube backgrounds of several 2-inch photomultiplier types having S11, 'S' , S13 and S20 cathodes are compared by measuring signal and background pulse height distributions at pulse heights corresponding to a few photo-electrons. The reference signal is generated by means of a {beta}-source and a plexiglass radiator. It is found that comparatively good results are obtained with selected tubes of the EMI types 6097B and 9514B having equivalent dark current dc values down to 10{sup -12} input lumens. Special interest is devoted to the correlation between the measured tube backgrounds and the dark current dc values of the tubes, as a good correlation between these parameters simplifies the selection of photomultiplier tubes. The equivalent dark currents of the tested tubes extend over the range 10{sup -12} to 10{sup -9} input lumens. Although the investigation deals with photomultiplier tubes intended for use in low level Cerenkov detectors it is believed that the results could be valuable in other fields where photomultiplier tubes are utilized for the detection of weak light pulses.

Photomultiplier tubes for Low Level Cerenkov Detectors

International Nuclear Information System (INIS)

Strindehag, O.

1965-03-01

Tube backgrounds of several 2-inch photomultiplier types having S11, 'S' , S13 and S20 cathodes are compared by measuring signal and background pulse height distributions at pulse heights corresponding to a few photo-electrons. The reference signal is generated by means of a β-source and a plexiglass radiator. It is found that comparatively good results are obtained with selected tubes of the EMI types 6097B and 9514B having equivalent dark current dc values down to 10 -12 input lumens. Special interest is devoted to the correlation between the measured tube backgrounds and the dark current dc values of the tubes, as a good correlation between these parameters simplifies the selection of photomultiplier tubes. The equivalent dark currents of the tested tubes extend over the range 10 -12 to 10 -9 input lumens. Although the investigation deals with photomultiplier tubes intended for use in low level Cerenkov detectors it is believed that the results could be valuable in other fields where photomultiplier tubes are utilized for the detection of weak light pulses

Performance of a monolithic LaBr{sub 3}:Ce crystal coupled to an array of silicon photomultipliers

Energy Technology Data Exchange (ETDEWEB)

Ulyanov, Alexei, E-mail: alexey.uliyanov@ucd.ie [School of Physics, University College Dublin, Belfield, Dublin 4 (Ireland); Morris, Oran [School of Physics, University College Dublin, Belfield, Dublin 4 (Ireland); Department of Computer Science & Applied Physics, Galway-Mayo Institute of Technology, Galway (Ireland); Hanlon, Lorraine; McBreen, Sheila; Foley, Suzanne; Roberts, Oliver J.; Tobin, Isaac; Murphy, David; Wade, Colin [School of Physics, University College Dublin, Belfield, Dublin 4 (Ireland); Nelms, Nick; Shortt, Brian [European Space Agency, ESTEC, 2200 AG Noordwijk (Netherlands); Slavicek, Tomas; Granja, Carlos; Solar, Michael [Institute of Experimental and Applied Physics, Czech Technical University in Prague, 12800 Prague 2 (Czech Republic)

2016-02-21

A gamma-ray detector composed of a single 28×28×20 mm{sup 3} LaBr{sub 3}:Ce crystal coupled to a custom built 4×4 array of silicon photomultipliers was tested over an energy range of 30 keV to 9.3 MeV. The silicon photomultipliers were initially calibrated using 20 ns light pulses generated by a light emitting diode. The photodetector responses measured as a function of the number of incident photons were found to be non-linear and consistent with model predictions. Using corrections for the non-linearity of the silicon photomultipliers, the detector showed a linear response to gamma-rays with energies from 100 keV to the maximum available energy of 9.3 MeV. The energy resolution was found to be 4% FWHM at 662 keV. Despite the large thickness of the scintillator (20 mm) and a 5 mm thick optical window, the detector was capable of measuring the positions of the gamma-ray interaction points. The position resolution was measured at 356 keV and was found to be 8 mm FWHM in the detector plane and 11 mm FWHM for the depth of interaction. The detector can be used as a building block of a larger calorimeter system that is capable of measuring gamma-ray energies up to tens of MeV.

Light emission efficiency and imaging properties of YAP:Ce granular phosphor screens

International Nuclear Information System (INIS)

Kalivas, N.; Valais, I.; Nikolopoulos, D.; Konstantinidis, A.; Cavouras, D.; Kandarakis, I.; Gaitanis, A.; Nomicos, C.D.; Panayiotakis, G.

2007-01-01

Phosphor materials are used in medical imaging combined with radiographic film or other photodetectors. Cerium (Ce 3+ ) -doped scintillators are of particular interest for medical imaging, because of their very fast response. YAP:Ce scintillator-based image detectors have already been evaluated in single-crystal form and under conditions of positron emission tomography and synchrotron or γ-ray irradiation. Furthermore, YAP:Ce phosphor has been evaluated in conjunction with radiographic films. The present work reports experimental and theoretical data concerning the light output absolute luminescence efficiency (AE) of the YAP:Ce screens under irradiation conditions employed in medical X-ray projection imaging (i.e., in diagnostic radiology). projection imaging (i.e., in diagnostic radiology). YAP:Ce phosphor screens with surface densities ranging between 53 and 110 mg/cm 2 were prepared by sedimentation on fused silica substrates in our laboratory. The resulted surface density of the screens was determined by dividing the phosphor mass deposited on the screen surface with the area of the surface. Additionally this work addresses the imaging performance of YAP:Ce by estimation of the detective quantum efficiency (DQE), i.e., the square of the signal to noise ratio transfer. Absolute efficiency was found to decrease with X-ray tube voltage for for YAP:Ce phosphor. The highest experimental efficiency was obtained for the 53.7 mg/cm 2 and 88.0 mg/cm 2 YAP:Ce screens. The highest DQE value was found for the 88.0 mg/cm 2 screen irradiated at 60 kVp. (orig.)

A hybrid metaheuristic for the time-dependent vehicle routing problem with hard time windows

Directory of Open Access Journals (Sweden)

N. Rincon-Garcia

2017-01-01

Full Text Available This article paper presents a hybrid metaheuristic algorithm to solve the time-dependent vehicle routing problem with hard time windows. Time-dependent travel times are influenced by different congestion levels experienced throughout the day. Vehicle scheduling without consideration of congestion might lead to underestimation of travel times and consequently missed deliveries. The algorithm presented in this paper makes use of Large Neighbourhood Search approaches and Variable Neighbourhood Search techniques to guide the search. A first stage is specifically designed to reduce the number of vehicles required in a search space by the reduction of penalties generated by time-window violations with Large Neighbourhood Search procedures. A second stage minimises the travel distance and travel time in an ‘always feasible’ search space. Comparison of results with available test instances shows that the proposed algorithm is capable of obtaining a reduction in the number of vehicles (4.15%, travel distance (10.88% and travel time (12.00% compared to previous implementations in reasonable time.

Timing coincidence studies with fast photomultipliers

International Nuclear Information System (INIS)

Raoof, M.A.; Raoof, S.A.

1981-01-01

The time response of RCA C70045D photomultipliers was studied using a subnanosecond light flasher. The tubes, which have an output rise time of approximately 0.5 ns, were used in coincidence to study the variations in the fwhm of the time spectrum over a certain dynamic range of pulse amplitudes for both leading edge and constant fraction discrimination. A comparison has also been made for the measured time resolutions with some of the other fast photomultipliers. (orig.)

Gain stabilization circuit of measuring devices with photomultipliers

International Nuclear Information System (INIS)

Seda, J.; Sabol, J.

1974-01-01

A circuit is designed for the stabilization of the gain of measuring devices with photomultipliers, suitable especially for the stabilization of scintillation detection systems, in which the correction signal is applied to the photomultiplier grid placed between the photocathode and the first dynode. (J.K.)

Pi3kcb links Hippo-YAP and PI3K-AKT signaling pathways to promote cardiomyocyte proliferation and survival.

Science.gov (United States)

Lin, Zhiqiang; Zhou, Pingzhu; von Gise, Alexander; Gu, Fei; Ma, Qing; Chen, Jinghai; Guo, Haidong; van Gorp, Pim R R; Wang, Da-Zhi; Pu, William T

2015-01-02

Yes-associated protein (YAP), the nuclear effector of Hippo signaling, regulates cellular growth and survival in multiple organs, including the heart, by interacting with TEA (transcriptional enhancer activator)-domain sequence-specific DNA-binding proteins. Recent studies showed that YAP stimulates cardiomyocyte proliferation and survival. However, the direct transcriptional targets through which YAP exerts its effects are poorly defined. To identify direct YAP targets that mediate its mitogenic and antiapoptotic effects in the heart. We identified direct YAP targets by combining differential gene expression analysis in YAP gain- and loss-of-function with genome-wide identification of YAP-bound loci using chromatin immunoprecipitation and high throughput sequencing. This screen identified Pik3cb, encoding p110β, a catalytic subunit of phosphoinositol-3-kinase, as a candidate YAP effector that promotes cardiomyocyte proliferation and survival. YAP and TEA-domain occupied a conserved enhancer within the first intron of Pik3cb, and this enhancer drove YAP-dependent reporter gene expression. Yap gain- and loss-of-function studies indicated that YAP is necessary and sufficient to activate the phosphoinositol-3-kinase-Akt pathway. Like Yap, Pik3cb gain-of-function stimulated cardiomyocyte proliferation, and Pik3cb knockdown dampened YAP mitogenic activity. Reciprocally, impaired heart function in Yap loss-of-function was significantly rescued by adeno-associated virus-mediated Pik3cb expression. Pik3cb is a crucial direct target of YAP, through which the YAP activates phosphoinositol-3-kinase-AKT pathway and regulates cardiomyocyte proliferation and survival. © 2014 American Heart Association, Inc.

Derin Yapı Yüzey Yapı İlişkisi Bağlamında Temel Dil Becerileri Üzerine Bir Analiz Çalışması

Directory of Open Access Journals (Sweden)

Bilginer ONAN

2015-07-01

Full Text Available Bu çalışmada, derin yapı yüzey yapı ilişkileri bağlamında, ana dili eğitiminde temel dil becerileri olarak kabul edilen dinleme, konuşma, okuma ve yazma kavramları analiz edilmiştir. Birinci bölümde, ilk kez Port Royal Gramer Okulu tarafından ortaya konan ve 1960’larda Noam Chomsky tarafından Üretimci Dönüşümsel Dil Bilgisi kuramıyla tekrar gündeme getirilen derin yapı ve yüzey yapı kavramları hakkında bilgi verilmiştir. Çalışmanın ikinci bölümünde ise derin yapı ve yüzey yapı ilişkileri çerçevesinde dinleme, konuşma, okuma ve yazma becerileri analiz edilmiştir. Çalışmanın amacı, dilin iki temel boyutu olan anlam ve biçim ilişkileri bağlamında, temel dil becerilerinin eğitimi sürecinde belirleyici olan unsurları tespit ederek, sürecin programlanmasına yönelik öneriler geliştirmektir. Çalışma çerçevesinde yapılan analizlerde boğumlama, bürün olguları, beden dili, üretici kelime hazinesi, alıcı kelime hazinesi, akıcılık, metin türü, yazım ve noktalama, bağdaşıklık, tutarlılık, ön bilgi, kelime tanıma, kelime ayırt etme, edinilmiş bilgi, önvarsayım, sezdirim kavramlarının derin yapı yüzey yapı ilişkileri bağlamında temel dil becerilerinin geliştirilmesinde süreci etkileyen unsurlar olduğu tespit edilmiştir. Bu kavramlar arasında boğumlama, bürün olgusu, beden dili, akıcılık, bağdaşıklık, metin türü, kelime tanıma, kelime ayırt etme, yazım ve noktalama, doğrudan yüzey yapıyla ilgilidir. Üretici kelime hazinesi, akıcılık, alıcı kelime hazinesi, tutarlılık, ön bilgi, edinilmiş bilgi, önvarsayım ve sezdirim kavramları ise derin yapıyı ilgilendirmektedir. Akıcılık kavramının bütün dil becerileriyle ilgili olduğu belirlenmiştir.

Nf2-Yap signaling controls the expansion of DRG progenitors and glia during DRG development.

Science.gov (United States)

Serinagaoglu, Yelda; Paré, Joshua; Giovannini, Marco; Cao, Xinwei

2015-02-01

Molecular mechanisms governing the maintenance and proliferation of dorsal root ganglia (DRG) progenitors are largely unknown. Here we reveal that the Hippo pathway regulates the expansion of DRG progenitors and glia during mammalian DRG development. The key effectors of this pathway, transcriptional coactivators Yap and Taz, are expressed in DRG progenitors and glia during DRG development but are at least partially inhibited from activating transcription. Aberrant YAP activation leads to overexpansion of DRG progenitor and glial populations. We further show that the Neurofibromatosis 2 (Nf2) tumor suppressor inhibits Yap during DRG development. Loss of Nf2 leads to similar phenotypes as does YAP hyperactivation, and deleting Yap suppresses these phenotypes. Our study demonstrates that Nf2-Yap signaling plays important roles in controlling the expansion of DRG progenitors and glia during DRG development. Copyright © 2014 Elsevier Inc. All rights reserved.

Vanillin causes the activation of Yap1 and mitochondrial fragmentation in Saccharomyces cerevisiae.

Science.gov (United States)

Nguyen, Trinh Thi My; Iwaki, Aya; Ohya, Yoshikazu; Izawa, Shingo

2014-01-01

Vanillin and furfural are derived from lignocellulosic biomass and inhibit yeast growth and fermentation as biomass conversion inhibitors. Furfural has been shown to induce oxidative stress in Saccharomyces cerevisiae. Since there has been no report on the relationship between vanillin and oxidative stress, we investigated whether vanillin caused oxidative stress in yeast cells. We showed that vanillin caused the nuclear accumulation of Yap1, an oxidative stress responsive transcription factor, and subsequent transcriptional activation of Yap1-target genes. The growth of the null mutant of the YAP1 gene (yap1Δ) was delayed in the presence of vanillin, which indicated that Yap1 plays a role in the acquisition of tolerance to vanillin. We also demonstrated that vanillin facilitated the fragmentation of mitochondria. These findings suggest that the toxicity of vanillin involves damage induced by oxidative stress. Copyright © 2013 The Society for Biotechnology, Japan. Published by Elsevier B.V. All rights reserved.

Performances of multi-channel ceramic photomultipliers

International Nuclear Information System (INIS)

Comby, G.; Karolak, M.; Piret, Y.; Mouly, J.P.

1995-09-01

Ceramic electron multipliers with real metal dynodes and independent channels ware constructed using multilayer ceramic technology. Tests of these prototypes show their capability to form sensitive detectors such as photomultipliers or light intensifiers. Here, we present results for the photocathode sensitivity, dynode activation, gain, linearity range and dynamic characteristics as well as the effect of 3-year aging of the main operational functions. The advantages provided by the ceramic components are discussed. These results motivate the development of a compact 256 pixel ceramic photomultiplier. (author)

Stabilization of the photomultiplier gain of a liquid scintillation counter

International Nuclear Information System (INIS)

Alkhazov, I.D.; Dmitriev, V.D.; Kuznetsov, A.V.; Malkin, L.Z.; Petrov, B.F.; Sheremet'ev, A.K.; Shpakov, V.I.

1987-01-01

A stabilization system of photomultiplier gain, where light-emitting diode flashes have been used to obtain a reference signal, is described. The diode is placed just in the liquid scintilllator volume. The stabilization system contains several (according to the number of photomultipliers) identical channels, which of them consists of a colorimeter, a control trigger and an integrator with an operational amplifier. Increase of photomultiplier stability is reached by changing voltage of photomultiplier power according to the reference signal amplitude. The level of background and efficiency of neutron detection by a scintillation counter are unchanged when using the stabilization system for 10 days of measurements

Time resolution performance studies of contemporary high speed photomultipliers

International Nuclear Information System (INIS)

Leskovar, B.; Lo, C.C.

1978-01-01

The time resolution capabilities of prototype microchannel plate and static crossed-field photomultipliers have been investigated. Measurements were made of electron transit time, rise time, time response, single phtoelectron time spread and multiphotoelectron time spread for LEP HR350 proximity focused high gain curved microchannel plate and VPM-154A/1.6L static crossed-field photomultipliers. The experimental data have been compared with results obtained with conventionally designed high speed photomultipliers. Descriptions are given of both the measuring techniques and the measuring systems. 16 refs

Hippo/Yap signaling controls epithelial progenitor cell proliferation and differentiation in the embryonic and adult lung

Science.gov (United States)

Lange, Alexander W.; Sridharan, Anusha; Xu, Yan; Stripp, Barry R.; Perl, Anne-Karina; Whitsett, Jeffrey A.

2015-01-01

The Hippo/Yap pathway is a well-conserved signaling cascade that regulates cell proliferation and differentiation to control organ size and stem/progenitor cell behavior. Following airway injury, Yap was dynamically regulated in regenerating airway epithelial cells. To determine the role of Hippo signaling in the lung, the mammalian Hippo kinases, Mst1 and Mst2, were deleted in epithelial cells of the embryonic and mature mouse lung. Mst1/2 deletion in the fetal lung enhanced proliferation and inhibited sacculation and epithelial cell differentiation. The transcriptional inhibition of cell proliferation and activation of differentiation during normal perinatal lung maturation were inversely regulated following embryonic Mst1/2 deletion. Ablation of Mst1/2 from bronchiolar epithelial cells in the adult lung caused airway hyperplasia and altered differentiation. Inhibitory Yap phosphorylation was decreased and Yap nuclear localization and transcriptional targets were increased after Mst1/2 deletion, consistent with canonical Hippo/Yap signaling. YAP potentiated cell proliferation and inhibited differentiation of human bronchial epithelial cells in vitro. Loss of Mst1/2 and expression of YAP regulated transcriptional targets controlling cell proliferation and differentiation, including Ajuba LIM protein. Ajuba was required for the effects of YAP on cell proliferation in vitro. Hippo/Yap signaling regulates Ajuba and controls proliferation and differentiation of lung epithelial progenitor cells. PMID:25480985

Advances in gas avalanche photomultipliers

CERN Document Server

Breskin, Amos; Buzulutskov, A F; Chechik, R; Garty, E; Shefer, G; Singh, B K

2000-01-01

Gas avalanche detectors, combining solid photocathodes with fast electron multipliers, provide an attractive solution for photon localization over very large sensitive areas and under high illumination flux. They offer single-photon sensitivity and the possibility of operation under very intense magnetic fields. We discuss the principal factors governing the operation of gas avalanche photomultipliers. We summarize the recent progress made in alkali-halide and CVD-diamond UV-photocathodes, capable of operation under gas multiplication, and novel thin-film protected alkali-antimonide photocathodes, providing, for the first time, the possibility of operating gas photomultipliers in the visible range. Electron multipliers, adequate for these photon detectors, are proposed and some applications are briefly discussed.

Scintillation counter: photomultiplier tube alignment

International Nuclear Information System (INIS)

Olson, R.E.

1975-01-01

A scintillation counter, particularly for counting gamma ray photons, includes a massive lead radiation shield surrounding a sample-receiving zone. The shield is disassembleable into a plurality of segments to allow facile installation and removal of a photomultiplier tube assembly, the segments being so constructed as to prevent straight-line access of external radiation through the shield into the sample receiving zone. Provisions are made for accurately aligning the photomultiplier tube with respect to one or more sample-transmitting bores extending through the shield to the sample receiving zone. A sample elevator, used in transporting samples into the zone, is designed to provide a maximum gamma-receiving aspect to maximize the gamma detecting efficiency. (auth)

Time resolution performance studies of contemporary high speed photomultipliers

International Nuclear Information System (INIS)

Leskovar, B.; Lo, C.C.

1977-01-01

The time resolution capabilities of prototype microchannel plate and static crossed-field photomultipliers have been investigated. Measurements were made of electron transit time, rise time, time response, single photoelectron time spread and multiphotoelectron time spread for LEP HR350 proximity focused high gain curved microchannel plate and VPM-154A/1.6L static crossed-field photomultipliers. The experimental data have been compared with results obtained with conventionally designed RCS 8850 and C31024 high speed photomultipliers. Descriptions are given of both the measuring techniques and the measuring systems

Future photomultiplier assemblies and associated electrons in large experiments

International Nuclear Information System (INIS)

Duteil, P.; Hammarstroem, R.; Innocenti, P.G.; Michelini, A.; Smith, B.; Soso, F.

1977-01-01

The results are presented of a working group study on reducing costs of proposed counter experiments in high-energy physics where several thousand photomultipliers are involved. Photomultiplier design is briefly discussed and new designs are presented for tube housings and high-voltage supplies. An outline presentation is given of a simplified electronics system, based on the Eurocard, for fast logic, data handling, and associated power supplies, suitable for photomultipliers or wire counters. Substantial savings in cost are shown to be possible without affecting performance but with some loss in convenience. (Auth.)

Noise in the Measurement of Light with Photomultipliers

Energy Technology Data Exchange (ETDEWEB)

Robben, F

1968-05-15

In order to be able to compare measurements derived from the anode current of a photomultiplier with measurement derived from photoelectron pulse counting, a systematic investigation of the properties of some photomultiplier tubes has been made. This has led to a correlation of the properties of a photomultiplier based on the quantum efficiency {eta}, the gain G, a photoelectron loss factor S and an effective dark rate D. In terms of these quantities the signal to noise ratio of an experimental measurement can be calculated, given the light flux and measurement technique. The fluctuations in a photomultiplier output are divided into two parts; Poisson fluctuations, and those due to excess noise. It is experimentally shown, from measurements on a 931A photomultiplier, that the excess noise exceeds the Poisson fluctuations only at very low frequencies, or long DC measurement times (> 10 s), for both pulse counting and anode current measurements. The Poisson fluctuations are found to be approximately the same for both pulse counting and anode current measurements, at both high light levels where the dark current, or dark pulses, are negligible, as well as at low light levels where the dark current is dominant. The excess noise is found to be somewhat greater in the case of anode current measurements. Thus both pulse counting and anode current measurement techniques have nearly identical noise properties, as far as the photomultiplier is concerned, and selection of either experimental technique depends primarily on the properties of the electronic equipment. By use of a synchronous detection technique, the variance of the pulse count was measured experimentally to an accuracy of {+-} 4 %, and was shown to be in agreement with that predicted by Poisson statistics.

The Hippo/YAP pathway interacts with EGFR signaling and HPV oncoproteins to regulate cervical cancer progression

Science.gov (United States)

He, Chunbo; Mao, Dagan; Hua, Guohua; Lv, Xiangmin; Chen, Xingcheng; Angeletti, Peter C; Dong, Jixin; Remmenga, Steven W; Rodabaugh, Kerry J; Zhou, Jin; Lambert, Paul F; Yang, Peixin; Davis, John S; Wang, Cheng

2015-01-01

The Hippo signaling pathway controls organ size and tumorigenesis through a kinase cascade that inactivates Yes-associated protein (YAP). Here, we show that YAP plays a central role in controlling the progression of cervical cancer. Our results suggest that YAP expression is associated with a poor prognosis for cervical cancer. TGF-α and amphiregulin (AREG), via EGFR, inhibit the Hippo signaling pathway and activate YAP to induce cervical cancer cell proliferation and migration. Activated YAP allows for up-regulation of TGF-α, AREG, and EGFR, forming a positive signaling loop to drive cervical cancer cell proliferation. HPV E6 protein, a major etiological molecule of cervical cancer, maintains high YAP protein levels in cervical cancer cells by preventing proteasome-dependent YAP degradation to drive cervical cancer cell proliferation. Results from human cervical cancer genomic databases and an accepted transgenic mouse model strongly support the clinical relevance of the discovered feed-forward signaling loop. Our study indicates that combined targeting of the Hippo and the ERBB signaling pathways represents a novel therapeutic strategy for prevention and treatment of cervical cancer. PMID:26417066

YAP Inhibition by Resveratrol via Activation of AMPK Enhances the Sensitivity of Pancreatic Cancer Cells to Gemcitabine

Directory of Open Access Journals (Sweden)

Zhengdong Jiang

2016-09-01

Full Text Available Resveratrol, a natural polyphenol present in most plants, inhibits the growth of numerous cancers both in vitro and in vivo. Aberrant expression of YAP has been reported to activate multiple growth-regulatory pathways and confer anti-apoptotic abilities to many cancer cells. However, the role of resveratrol in YES-activated protein (YAP expression and that of YAP in pancreatic cancer cells’ response to gemcitabine resistance remain elusive. In this study, we found that resveratrol suppressed the proliferation and cloning ability and induced the apoptosis of pancreatic cancer cells. These multiple biological effects might result from the activation of AMP-activation protein kinase (AMPK (Thr172 and, thus, the induction of YAP cytoplasmic retention, Ser127 phosphorylation, and the inhibition of YAP transcriptional activity by resveratrol. YAP silencing by siRNA or resveratrol enhanced the sensitivity of gemcitabine in pancreatic cancer cells. Taken together, these findings demonstrate that resveratrol could increase the sensitivity of pancreatic cancer cells to gemcitabine by inhibiting YAP expression. More importantly, our work reveals that resveratrol is a potential anticancer agent for the treatment of pancreatic cancer, and YAP may serve as a promising target for sensitizing pancreatic cancer cells to chemotherapy.

Linearity measurement of the XP 1210 fast photomultiplier tube

International Nuclear Information System (INIS)

Breuze, G.; Sawine, P.

1969-01-01

A new X Y method of photomultipliers linearity measurement has been tested which is more suitable for fast photomultiplier tubes. The XP 1210 gives a linearity limit of 70 mA for the gain 10, i.e. 3.5 V for a 50 Ω charge impedance

Transcriptional integration of mitogenic and mechanical signals by Myc and YAP.

Science.gov (United States)

Croci, Ottavio; De Fazio, Serena; Biagioni, Francesca; Donato, Elisa; Caganova, Marieta; Curti, Laura; Doni, Mirko; Sberna, Silvia; Aldeghi, Deborah; Biancotto, Chiara; Verrecchia, Alessandro; Olivero, Daniela; Amati, Bruno; Campaner, Stefano

2017-10-15

Mammalian cells must integrate environmental cues to determine coherent physiological responses. The transcription factors Myc and YAP-TEAD act downstream from mitogenic signals, with the latter responding also to mechanical cues. Here, we show that these factors coordinately regulate genes required for cell proliferation. Activation of Myc led to extensive association with its genomic targets, most of which were prebound by TEAD. At these loci, recruitment of YAP was Myc-dependent and led to full transcriptional activation. This cooperation was critical for cell cycle entry, organ growth, and tumorigenesis. Thus, Myc and YAP-TEAD integrate mitogenic and mechanical cues at the transcriptional level to provide multifactorial control of cell proliferation. © 2017 Croci et al.; Published by Cold Spring Harbor Laboratory Press.

A new supply chain management method with one-way time window: A hybrid PSO-SA approach

Directory of Open Access Journals (Sweden)

Reza Tavakkoli-Moghaddam

2012-01-01

Full Text Available In this paper, we study a supply chain problem where a whole seller/producer distributes goods among different retailers. The proposed model of this paper is formulated as a more general and realistic form of traditional vehicle routing problem (VRP. The main advantages of the new proposed model are twofold. First, the time window does not consider any lower bound and second, it treats setup time as separate cost components. The resulted problem is solved using a hybrid of particle swarm optimization and simulated annealing (PSO-SA. The results are compared with other hybrid method, which is a combination of Ant colony and Tabu search. We use some well-known benchmark problems to compare the results of our proposed model with other method. The preliminary results indicate that the proposed model of this paper performs reasonably well.

Geneva University - Silicon photomultiplier : features and applications

CERN Multimedia

Université de Genève

2012-01-01

GENEVA UNIVERSITY École de physique Département de physique nucléaire et corspusculaire 24, quai Ernest-Ansermet 1211 Genève 4 Tél.: (022) 379 62 73 Fax: (022) 379 69 92   Wednesday 7 March 2012 SEMINAIRE DE PHYSIQUE CORPUSCULAIRE 11.15 a.m. - Science II, Auditoire 1S081, 30, quai Ernest-Ansermet, 1211 Genève 4 SILICON PHOTOMULTIPLIER : FEATURES AND APPLICATIONS Dr Giulio SARACINO   University of Naples, Federico II   Silicon photomultipliers were developed about ten years ago and their use, unlike traditional photomultiplier tubes, is increasing more and more. They are an evolution of the avalanche photodiode working in Geiger mode regime. Hundreds of such diodes are connected in parallel, allowing single photon response, high detection efficiency, high gain at low bias voltage and very good timing performance. In spite of their Geiger regime, they can be considered linear devices, until the number of photon...

Yap1 is dispensable for self-renewal but required for proper differentiation of mouse embryonic stem (ES) cells.

Science.gov (United States)

Chung, HaeWon; Lee, Bum-Kyu; Uprety, Nadima; Shen, Wenwen; Lee, Jiwoon; Kim, Jonghwan

2016-04-01

Yap1 is a transcriptional co-activator of the Hippo pathway. The importance of Yap1 in early cell fate decision during embryogenesis has been well established, though its role in embryonic stem (ES) cells remains elusive. Here, we report that Yap1 plays crucial roles in normal differentiation rather than self-renewal of ES cells. Yap1-depleted ES cells maintain undifferentiated state with a typical colony morphology as well as robust alkaline phosphatase activity. These cells also retain comparable levels of the core pluripotent factors, such as Pou5f1 and Sox2, to the levels in wild-type ES cells without significant alteration of lineage-specific marker genes. Conversely, overexpression of Yap1 in ES cells promotes nuclear translocation of Yap1, resulting in disruption of self-renewal and triggering differentiation by up-regulating lineage-specific genes. Moreover, Yap1-deficient ES cells show impaired induction of lineage markers during differentiation. Collectively, our data demonstrate that Yap1 is a required factor for proper differentiation of mouse ES cells, while remaining dispensable for self-renewal. © 2016 The Authors.

Evaluation of new 5 inch photomultiplier for use in threshold Cherenkov detectors with aerogel radiator

International Nuclear Information System (INIS)

Wojtsekhowski, B.; Zorn, C.; Flyckt, S.O.

2000-01-01

A cost effective alternative to UV-sensitive 5 inch PMTs often used with threshold Aerogel Cherenkov detectors has been developed and tested. The photomultiplier -XP4572-is a variation of the Photonis XP4512 glass window tube with improved electron collection efficiency. Fast timing and high gain were only moderately compromised. The effective quantum efficiency has been measured as twice that of a Burle 8854 Quantacon when exposed to a Cherenkov spectrum generated by Ru-106 electrons (les;3.54 MeV) through 1 cm of high index, high transparency Matsushita Electric aerogel (n=1.05). This new phototube is being installed in an aerogel-based Cherenkov detector for Hall A at Jefferson Lab

Monte Carlo calculations of the optical coupling between bismuth germanate crystals and photomultiplier tubes

International Nuclear Information System (INIS)

Derenzo, S.E.; Riles, J.K.

1981-10-01

The high density and atomic number of bismuth germanate (Bi 4 Ge 3 O 12 or BGO) make it a very useful detector for positron emission tomography. Modern tomograph designs use large numbers of small, closely-packed crystals for high spatial resolution and high sensitivity. However, the low light output, the high refractive index (n=2.15), and the need for accurate timing make it important to optimize the transfer of light to the photomultiplier tube (PMT). We describe the results of a Monte Carlo computer program developed to study the effect of crystal shape, reflector type, and the refractive index of the PMT window on coupling efficiency. The program simulates total internal, external, and Fresnel reflection as well as internal absorption and scattering by bubbles

Acquisition of omptin reveals cryptic virulence function of autotransporter YapE in Yersinia pestis

Science.gov (United States)

Pennington, Jarrod; Miller, Virginia L.

2013-01-01

SUMMARY Autotransporters, the largest family of secreted proteins in Gram negative bacteria, perform a variety of functions, including adherence, cytotoxicity, and immune evasion. In Yersinia pestis the autotransporter YapE has adhesive properties and contributes to bubonic infection of the mouse model. Here, we demonstrate that omptin cleavage of Y. pestis YapE is required to mediate bacterial aggregation and adherence to eukaryotic cells. We demonstrate that omptin cleavage is specific for the Y. pestis and Y. pseudotuberculosis YapE orthologs but is not conserved in the Y. enterocolitica protein. We also show that cleavage of YapE occurs in Y. pestis but not in the enteric Yersinia species, and requires the omptin Pla (plasminogen activator protease), which is encoded on the Y. pestis-specific plasmid pPCP1. Together, these data show that post-translation modification of YapE appears to be specific to Y. pestis, was acquired along with the acquisition of pPCP1 during the divergence of Y. pestis from Y. pseudotuberculosis, and are the first evidence of a novel mechanism to regulate bacterial adherence. PMID:23701256

Position-sensitive gaseous photomultipliers research and applications

CERN Document Server

Francke, Tom; Peskov, Vladimir

2016-01-01

Gaseous photomultipliers are defined as gas-filled devices capable of recording single ultraviolet (UV) and visible photons with high position resolution. Used in a variety of research areas, these detectors can be paired with computers to treat and store imaging information of UV-light. Position-Sensitive Gaseous Photomultipliers: Research and Applications explores the advancement of gaseous detectors as applied for single photon detection. Emphasizing emerging perspectives and new ways to apply gaseous detectors across research fields, this research-based publication is an essential reference source for engineers, physicists, graduate-level students, and researchers.

VUV-sensitive silicon-photomultipliers for the nEXO-experiment

Energy Technology Data Exchange (ETDEWEB)

Wrede, Gerrit; Bayerlein, Reimund; Hufschmidt, Patrick; Jamil, Ako; Schneider, Judith; Wagenpfeil, Michael; Ziegler, Tobias; Hoessl, Juergen; Anton, Gisela; Michel, Thilo [ECAP, Friedrich-Alexander-Universitaet Erlangen-Nuernberg (Germany)

2016-07-01

The nEXO (next Enriched Xenon Observatory) experiment will search for the neutrinoless double beta decay of Xe-136 with a liquid xenon TPC (Time ProjectionChamber). The sensitivity of the experiment is related to the energy resolution, which itself depends on the accuracies of the measurements of the amount of drifting electrons and the number of scintillation photons with their wavelength being in the vacuum ultraviolet band. Silicon Photomultipliers (SiPM) shall be used for the detection of the scintillation light, since they can be produced extremely radiopure. Commercially available SiPM do not fulfill all requirements of the nEXO experiment, thus a dedicated development is necessary. To characterize the silicon photomultipliers, we have built a test apparatus for xenon liquefaction, in which a VUV-sensitive photomultiplier tube can be operated together with the SiPM. In this contribution we present our apparatus for the SiPM characterization measurements and our latest results on the test of the silicon photomultipliers for the detection of xenon scintillation light.

Forest pathology in Yap, Palau, Pohnpei, Kosrae, Guam and Saipan, Sept. 2013

Science.gov (United States)

Phil Cannon

2014-01-01

In September of 2013, an opportunity was seized by the Regional Forest Pathologist to do some work on the following islands in Micronesia and the Marianas: Yap, Palau, Guam, Saipan, Pohnpei, and Kosrae. The principle justification for doing the work at this time was that satellite images showed large areas of dead mangroves on Yap (Liu, pers. com). Many...

Light Production in the Double Chooz Photomultiplier Tubes

Energy Technology Data Exchange (ETDEWEB)

Calvo, E.; Cerrada, M.; Crespo, J. I.; Gil-Botella, I.; Jimenez, S.; Lopez, M.; Novella, P.; Palomares, C.; Santorelli, R.; Verdugo, A.

2012-09-13

In this document we present a study of the phenomenon of light emission (called glowing) in the bases of the Hamamatsu R7081MOD-ASSY photomultiplier tubes (PMTs) used in the Double Chooz experiment. The tests have been carried out at the CIEMAT laboratories over a photomultiplier tube of the same model. We have studied the phenomenon making first a characterization of it, and then focusing on the dependence of the rate and the amount of emitted light versus voltage and temperature. In addition, we have looked for the possible existence of an ultraviolet component in the light which would be harmful for the experiment because it could be able to excite the scintillator liquid. Finally, we propose and test a method to reduce the light emission using a cover on the base of the photomultiplier tube.. (Author)

Silicon photomultipliers for scintillating trackers

Energy Technology Data Exchange (ETDEWEB)

Rabaioli, S., E-mail: simone.rabaioli@gmail.com [Universita degli Studi dell' Insubria, Via Valleggio, 11 - 22100 Como (Italy); Berra, A.; Bolognini, D. [Universita degli Studi dell' Insubria, Via Valleggio, 11 - 22100 Como (Italy); INFN sezione di Milano Bicocca (Italy); Bonvicini, V. [INFN sezione di Trieste (Italy); Bosisio, L. [Universita degli Studi di Trieste and INFN sezione di Trieste (Italy); Ciano, S.; Iugovaz, D. [INFN sezione di Trieste (Italy); Lietti, D. [Universita degli Studi dell' Insubria, Via Valleggio, 11 - 22100 Como (Italy); INFN sezione di Milano Bicocca (Italy); Penzo, A. [INFN sezione di Trieste (Italy); Prest, M. [Universita degli Studi dell' Insubria, Via Valleggio, 11 - 22100 Como (Italy); INFN sezione di Milano Bicocca (Italy); Rashevskaya, I.; Reia, S. [INFN sezione di Trieste (Italy); Stoppani, L. [Universita degli Studi dell' Insubria, Via Valleggio, 11 - 22100 Como (Italy); Vallazza, E. [INFN sezione di Trieste (Italy)

2012-12-11

In recent years, silicon photomultipliers (SiPMs) have been proposed as a new kind of readout device for scintillating detectors in many experiments. A SiPM consists of a matrix of parallel-connected pixels, which are independent photon counters working in Geiger mode with very high gain ({approx}10{sup 6}). This contribution presents the use of an array of eight SiPMs (manufactured by FBK-irst) for the readout of a scintillating bar tracker (a small size prototype of the Electron Muon Ranger detector for the MICE experiment). The performances of the SiPMs in terms of signal to noise ratio, efficiency and time resolution will be compared to the ones of a multi-anode photomultiplier tube (MAPMT) connected to the same bars. Both the SiPMs and the MAPMT are interfaced to a VME system through a 64 channel MAROC ASIC.

Silicon photomultipliers for scintillating trackers

Science.gov (United States)

Rabaioli, S.; Berra, A.; Bolognini, D.; Bonvicini, V.; Bosisio, L.; Ciano, S.; Iugovaz, D.; Lietti, D.; Penzo, A.; Prest, M.; Rashevskaya, I.; Reia, S.; Stoppani, L.; Vallazza, E.

2012-12-01

In recent years, silicon photomultipliers (SiPMs) have been proposed as a new kind of readout device for scintillating detectors in many experiments. A SiPM consists of a matrix of parallel-connected pixels, which are independent photon counters working in Geiger mode with very high gain (∼106). This contribution presents the use of an array of eight SiPMs (manufactured by FBK-irst) for the readout of a scintillating bar tracker (a small size prototype of the Electron Muon Ranger detector for the MICE experiment). The performances of the SiPMs in terms of signal to noise ratio, efficiency and time resolution will be compared to the ones of a multi-anode photomultiplier tube (MAPMT) connected to the same bars. Both the SiPMs and the MAPMT are interfaced to a VME system through a 64 channel MAROC ASIC.

RUNX1 and RUNX3 protect against YAP-mediated EMT, stem-ness and shorter survival outcomes in breast cancer

Science.gov (United States)

Kulkarni, Madhura; Tan, Tuan Zea; Syed Sulaiman, Nurfarhanah Bte; Lamar, John M.; Bansal, Prashali; Cui, Jianzhou; Qiao, Yiting; Ito, Yoshiaki

2018-01-01

Hippo pathway target, YAP has emerged as an important player in solid tumor progression. Here, we identify RUNX1 and RUNX3 as novel negative regulators of oncogenic function of YAP in the context of breast cancer. RUNX proteins are one of the first transcription factors identified to interact with YAP. RUNX1 or RUNX3 expression abrogates YAP-mediated pro-tumorigenic properties of mammary epithelial cell lines in an interaction dependent manner. RUNX1 and RUNX3 inhibit YAP-mediated migration and stem-ness properties of mammary epithelial cell lines by co-regulating YAP-mediated gene expression. Analysis of whole genome expression profiles of breast cancer samples revealed significant co-relation between YAP–RUNX1/RUNX3 expression levels and survival outcomes of breast cancer patients. High RUNX1/RUNX3 expression proved protective towards YAP-dependent patient survival outcomes. High YAP in breast cancer patients’ expression profiles co-related with EMT and stem-ness gene signature enrichment. High RUNX1/RUNX3 expression along with high YAP reflected lower enrichment of EMT and stem-ness signatures. This antagonistic activity of RUNX1 and RUNX3 towards oncogenic function of YAP identified in mammary epithelial cells as well as in breast cancer expression profiles gives a novel mechanistic insight into oncogene–tumor suppressor interplay in the context of breast cancer progression. The novel interplay between YAP, RUNX1 and RUNX3 and its significance in breast cancer progression can serve as a prognostic tool to predict cancer recurrence. PMID:29581836

Geometrik Yapıların İnşasında Pergel ve Çizgecin Kullanımı

OpenAIRE

Erduran, Ayten; Yeşildere, Sibel

2010-01-01

Bu yapıda üç matematik öğretinin pergel ve çizgeçmenin geometrik yapıları süreçleri incelenmektedir. Öğretmenlerin geometri yapı yapımı ve ilgili dersleri video kamera ile kaydedilmiş ve derslerdeki öğretmen-öğrenci-araç üçlüsü arasındaki etkileşim incelenmiştir. Ders Kitaplığı içeren öğretmenlerle görüşmeler yapıldı. Çalışmada üç matematik öğretmeninin pergel ve çizgeci geometrik yapılar yapı mühendisliği. Araştırma pergel ve çizgeçle geometrik yapıların inşasına ezbere bir anlayışla öğretme...

Indigenous Fallow Management on Yap Island

Science.gov (United States)

M.V.C. Falanruw; Francis Ruegorong

2002-01-01

On Yap Island, indigenous management of the fallow in shifting agriculture has resulted in the development of site-stable taro patch and tree garden agroforestry systems. These systems are relatively sustainable and supportive of household economies , with some surplus for local market sales. however, a broad range of crops whose harvest is complementary to those...

Hippo Signaling Regulates Pancreas Development through Inactivation of Yap

Science.gov (United States)

Day, Caroline E.; Boerner, Brian P.; Johnson, Randy L.; Sarvetnick, Nora E.

2012-01-01

The mammalian pancreas is required for normal metabolism, with defects in this vital organ commonly observed in cancer and diabetes. Development must therefore be tightly controlled in order to produce a pancreas of correct size, cell type composition, and physiologic function. Through negative regulation of Yap-dependent proliferation, the Hippo kinase cascade is a critical regulator of organ growth. To investigate the role of Hippo signaling in pancreas biology, we deleted Hippo pathway components in the developing mouse pancreas. Unexpectedly, the pancreas from Hippo-deficient offspring was reduced in size, with defects evident throughout the organ. Increases in the dephosphorylated nuclear form of Yap are apparent throughout the exocrine compartment and correlate with increases in levels of cell proliferation. However, the mutant exocrine tissue displays extensive disorganization leading to pancreatitis-like autodigestion. Interestingly, our results suggest that Hippo signaling does not directly regulate the pancreas endocrine compartment as Yap expression is lost following endocrine specification through a Hippo-independent mechanism. Altogether, our results demonstrate that Hippo signaling plays a crucial role in pancreas development and provide novel routes to a better understanding of pathological conditions that affect this organ. PMID:23071096

Externally mounted radioactivity detector for MWD employing radial inline scintillator and photomultiplier tube

International Nuclear Information System (INIS)

Meisner, J.E.; Mumby, E.S.; Groeschel, V.E.

1991-01-01

Improved radioactivity well logging may be achieved by mounting a scintillator and photomultiplier tube in a single case interfacing with a hole extending through a drill collar at the lower end of a drill string so that measurements can be made while drilling. Radioactive sources (when required for well logging) are mounted in cavities which open to the exterior of the drill collar. Light from the scintillator is coupled directly to the aligned photomultiplier tube both of which are mounted in a case extending radially within the drill collar and sealingly engaging an electronics housing within the drill collar and the drill collar wall surrounding the hole. The scintillator is of greater diameter than the photomultiplier tube. A frustoconical light pipe connects the scintillator and the photomultiplier tube, channeling scintillation in the crystal to the photomultiplier to provide an amplified detection capability over that for a scintillator having the same diameter as the photomultiplier tube. (author)

YAP1 regulates prostate cancer stem cell-like characteristics to promote castration resistant growth

DEFF Research Database (Denmark)

Jiang, Ning; Ke, Binghu; Hjort-Jensen, Kim

2017-01-01

Castration resistant prostate cancer (CRPC) is a stage of relapse that arises after various forms of androgen ablation therapy (ADT) and causes significant morbidity and mortality. However, the mechanism underlying progression to CRPC remains poorly understood. Here, we report that YAP1, which...... is negatively regulated by AR, influences prostate cancer (PCa) cell self-renewal and CRPC development. Specifically, we found that AR directly regulates the methylation of YAP1 gene promoter via the formation of a complex with Polycomb group protein EZH2 and DNMT3a. In normal conditions, AR recruits EZH2......-differentiation of PCa cells to stem/progenitor-like cells (PCSC), which potentially contribute to disease recurrence. Finally, the knock down of YAP1 expression or the inhibition of YAP1 function by Verteporfin in TRAMP prostate cancer mice significantly suppresses tumor recurrence following castration. In conclusion...

Overexpression of the transcription factor Yap1 modifies intracellular redox conditions and enhances recombinant protein secretion

Directory of Open Access Journals (Sweden)

Marizela Delic

2014-10-01

Full Text Available Oxidative folding of secretory proteins in the endoplasmic reticulum (ER is a redox active process, which also impacts the redox conditions in the cytosol. As the transcription factor Yap1 is involved in the transcriptional response to oxidative stress, we investigate its role upon the production of secretory proteins, using the yeast Pichia pastoris as model, and report a novel important role of Yap1 during oxidative protein folding. Yap1 is needed for the detoxification of reactive oxygen species (ROS caused by increased oxidative protein folding. Constitutive co-overexpression of PpYAP1 leads to increased levels of secreted recombinant protein, while a lowered Yap1 function leads to accumulation of ROS and strong flocculation. Transcriptional analysis revealed that more than 150 genes were affected by overexpression of YAP1, in particular genes coding for antioxidant enzymes or involved in oxidation-reduction processes. By monitoring intracellular redox conditions within the cytosol and the ER using redox-sensitive roGFP1 variants, we could show that overexpression of YAP1 restores cellular redox conditions of protein-secreting P. pastoris by reoxidizing the cytosolic redox state to the levels of the wild type. These alterations are also reflected by increased levels of oxidized intracellular glutathione (GSSG in the YAP1 co-overexpressing strain. Taken together, these data indicate a strong impact of intracellular redox balance on the secretion of (recombinant proteins without affecting protein folding per se. Re-establishing suitable redox conditions by tuning the antioxidant capacity of the cell reduces metabolic load and cell stress caused by high oxidative protein folding load, thereby increasing the secretion capacity.

Chemical Characteristics of Seawater and Sediment in the Yap Trench

Science.gov (United States)

Ding, H.; Sun, C.; Yang, G.

2017-12-01

In June 2016, seawater samples at sediment-seawater interface and sediment samples were collected by the he Jiaolong, China's manned submersible, at four sampling sites located in the Yap Trench. Seawater samples from different depths of the trench were also collected by CTD. Chemical parameters, including pH, alkanility, concentrations of dissolved inorganic carbon, dissolved and total organic carbon, methane, dimethylsulfoniopropionate, nutrients, carbohydrates, and amino acids were analyzed in the seawater samples. Concentrations of total organic carbon, six constant elements and nine trace elements were determined in the sediment samples. All the vertical profiles of the chemical parameters in the seawater have unique characteristics. Our resluts also showed that the carbonate compensation depth (CCD) was between 4500 m and 5000 m in the trench. The hadal sediment at 6500 m depth under the CCD line was siliceous ooze favored for the burial of orgaic carbon, attributed to accumulation of surface sediment by gravity flow. The abyssal sediment at the 4500 m depth was calcareous ooze. Various microfossils, such as discoasters and diatoms, were identified in different sediment layers of the sediment samples.Based on the ratios of Fe/Al and Ti/Al, and the correlation between different elements, the sediment in the Yap Trench were derived from biogenic, terrestrial, volcanic and autogenic sources. The ratios of Ni/Co and V/Cr showed that the deposition environment of the trench should be oxidative, arributed to inflow of the Antractic bottom oxygen-rich seawater.The high concentraiont of Ca in the sediment from the station 371-Yap-S02 below 4 cm depth indicated that there was no large-scale volcanic eruption in the research area and the volcanic materials in the sediment might orginated from the Mariana Volcanic Arc, and the Carolyn Ridge has been slowly sinking on the east side of the trench due to plate subduction. This study is the first systematic study of

Nuclear localization of the transcriptional coactivator YAP is associated with invasive lobular breast cancer

NARCIS (Netherlands)

Vlug, E.J.; Ven, R.A. van de; Vermeulen, J.F.; Bult, P.; Diest, P.J. van; Derksen, P.W.B.

2013-01-01

BACKGROUND: Yes Associated Protein (YAP) has been implicated in the control of organ size by regulating cell proliferation and survival. YAP is a transcriptional coactivator that controls cellular responses through interaction with TEAD transcription factors in the nucleus, while its transcriptional

Pulse shape discrimination based on fast signals from silicon photomultipliers

Science.gov (United States)

Yu, Junhao; Wei, Zhiyong; Fang, Meihua; Zhang, Zixia; Cheng, Can; Wang, Yi; Su, Huiwen; Ran, Youquan; Zhu, Qingwei; Zhang, He; Duan, Kai; Chen, Ming; Liu, Meng

2018-06-01

Recent developments in organic plastic scintillators capable of pulse shape discrimination (PSD) enable a breakthrough in discrimination between neutrons and gammas. Plastic scintillator detectors coupled with silicon photomultipliers (SiPMs) offer many advantages, such as lower power consumption, smaller volume, and especially insensitivity to magnetic fields, compared with conventional photomultiplier tubes (PMTs). A SensL SiPM has two outputs: a standard output and a fast output. It is known that the charge injected into the fast output electrode is typically approximately 2% of the total charge generated during the avalanche, whereas the charge injected into the standard output electrode is nearly 98% of the total. Fast signals from SiPMs exhibit better performance in terms of timing and time-correlated measurements compared with standard signals. The pulse duration of a standard signal is on the order of hundreds of nanoseconds, whereas the pulse duration of the main monopole waveform of a fast signal is a few tens of nanoseconds. Fast signals are traditionally thought to be suitable for photon counting at very high speeds but unsuitable for PSD due to the partial charge collection. Meanwhile, the standard outputs of SiPMs coupled with discriminating scintillators have yielded nice PSD performances, but there have been no reports on PSD using fast signals. Our analysis shows that fast signals can also provide discrimination if the rate of charge injection into the fast output electrode is fixed for each event, even though only a portion of the charge is collected. In this work, we achieved successful PSD using fast signals; meanwhile, using a coincidence timing window of less 3 nanoseconds between the readouts from both ends of the detector reduced the influence of the high SiPM dark current. We experimentally achieved good timing performance and PSD capability simultaneously.

Application of CMOS Technology to Silicon Photomultiplier Sensors

Science.gov (United States)

D’Ascenzo, Nicola; Zhang, Xi; Xie, Qingguo

2017-01-01

We use the 180 nm GLOBALFOUNDRIES (GF) BCDLite CMOS process for the production of a silicon photomultiplier prototype. We study the main characteristics of the developed sensor in comparison with commercial SiPMs obtained in custom technologies and other SiPMs developed with CMOS-compatible processes. We support our discussion with a transient modeling of the detection process of the silicon photomultiplier as well as with a series of static and dynamic experimental measurements in dark and illuminated environments. PMID:28946675

Study of large hemispherical photomultiplier tubes for the ANTARES neutrino telescope

Science.gov (United States)

Aguilar, J. A.; Albert, A.; Ameli, F.; Amram, P.; Anghinolfi, M.; Anton, G.; Anvar, S.; Ardellier-Desages, F. E.; Aslanides, E.; Aubert, J.-J.; Bailey, D.; Basa, S.; Battaglieri, M.; Becherini, Y.; Bellotti, R.; Beltramelli, J.; Bertin, V.; Billault, M.; Blaes, R.; Blanc, F.; de Botton, N.; Boulesteix, J.; Bouwhuis, M. C.; Brooks, C. B.; Bradbury, S. M.; Bruijn, R.; Brunner, J.; Burgio, G. F.; Cafagna, F.; Calzas, A.; Capone, A.; Caponetto, L.; Carmona, E.; Carr, J.; Cartwright, S. L.; Castorina, E.; Cavasinni, V.; Cecchini, S.; Charvis, P.; Circella, M.; Colnard, C.; Compère, C.; Coniglione, R.; Cooper, S.; Coyle, P.; Cuneo, S.; Damy, G.; van Dantzig, R.; Deschamps, A.; de Marzo, C.; Denans, D.; Destelle, J.-J.; de Vita, R.; Dinkelspiler, B.; Distefano, C.; Drogou, J.-F.; Druillole, F.; Engelen, J.; Ernenwein, J.-P.; Falchini, E.; Favard, S.; Feinstein, F.; Ferry, S.; Festy, D.; Flaminio, V.; Fopma, J.; Fuda, J.-L.; Gallone, J.-M.; Giacomelli, G.; Girard, N.; Goret, P.; Graf, K.; Hallewell, G.; Hartmann, B.; Heijboer, A.; Hello, Y.; Hernández-Rey, J. J.; Herrouin, G.; Hößl, J.; Hoffmann, C.; Hubbard, J. R.; Jaquet, M.; de Jong, M.; Jouvenot, F.; Kappes, A.; Karg, T.; Karkar, S.; Karolak, M.; Katz, U.; Keller, P.; Kooijman, P.; Korolkova, E. V.; Kouchner, A.; Kretschmer, W.; Kuch, S.; Kudryavtsev, V. A.; Lafoux, H.; Lagier, P.; Lahmann, R.; Lamare, P.; Languillat, J.-C.; Laschinsky, H.; Laubier, L.; Legou, T.; Le Guen, Y.; Le Provost, H.; Le van Suu, A.; Lo Nigro, L.; Lo Presti, D.; Loucatos, S.; Louis, F.; Lyashuk, V.; Marcelin, M.; Margiotta, A.; Maron, C.; Massol, A.; Masullo, R.; Mazéas, F.; Mazure, A.; McMillan, J. E.; Migneco, E.; Millot, C.; Milovanovic, A.; Montanet, F.; Montaruli, T.; Morel, J.-P.; Morganti, M.; Moscoso, L.; Musumeci, M.; Naumann, C.; Naumann-Godo, M.; Nezri, E.; Niess, V.; Nooren, G. J.; Ogden, P.; Olivetto, C.; Palanque-Delabrouille, N.; Papaleo, R.; Payre, P.; Petta, C.; Piattelli, P.; Pineau, J.-P.; Poinsignon, J.; Popa, V.; Potheau, R.; Pradier, T.; Racca, C.; Raia, G.; Randazzo, N.; Real, D.; van Rens, B. A. P.; Réthoré, F.; Riccobene, G.; Rigaud, V.; Ripani, M.; Roca-Blay, V.; Rolin, J.-F.; Romita, M.; Rose, H. J.; Rostovtsev, A.; Ruppi, M.; Russo, G. V.; Sacquin, Y.; Salesa, F.; Salomon, K.; Saouter, S.; Sapienza, P.; Shanidze, R.; Schuller, J.-P.; Schuster, W.; Sokalski, I.; Spurio, M.; Stolarczyk, T.; Stubert, D.; Taiuti, M.; Thompson, L. F.; Tilav, S.; Valdy, P.; Valente, V.; Vallage, B.; Vernin, P.; Virieux, J.; de Vries, G.; de Witt Huberts, P.; de Wolf, E.; Zaborov, D.; Zaccone, H.; Zakharov, V.; Zornoza, J. D.; Zúñiga, J.

2005-12-01

The ANTARES neutrino telescope, to be immersed depth in the Mediterranean Sea, will consist of a three-dimensional matrix of 900 large area photomultiplier tubes housed in pressure-resistant glass spheres. The selection of the optimal photomultiplier was a critical step for the project and required an intensive phase of tests and developments carried out in close collaboration with the main manufacturers worldwide. This paper provides an overview of the tests performed by the collaboration and describes in detail the features of the photomultiplier tube chosen for ANTARES.

Scintillating fibre detectors using position-sensitive photomultipliers

International Nuclear Information System (INIS)

Agoritsas, V.; Bergdolt, A.M.; Bing, O.; Bravar, A.; Ditta, J.; Drevenak, R.

1995-01-01

Scintillating fibre technology has made substantial progress, and has demonstrated great potential for fast tracking and triggering in high luminosity experiments in Particle Physics. Some recent issues of the RD-17 project at CERN are presented for fast and precise readout of scintillating fibre arrays, as well as for upgrade of position-sensitive photomultipliers. Excellent matching of the scintillating fibre and the position-sensitive photomultiplier, in particular in time characteristics, allowed to achieve excellent detector performances, typically a spatial resolution of ∼ 125 μm with time resolution better than 1 ns and detection efficiency greater than 95%. (author)10 refs.; 25 figs.; 1 tab

YAP:Ce and CsI(Tl) detectors for dielectronic recombination experiment at the CSRm

International Nuclear Information System (INIS)

Wen, W.Q.; Ma, X.; Xu, W.Q.; Meng, L.J.; Zhu, X.L.; Gao, Y.; Wang, S.L.; Zhang, P.J.; Zhao, D.M.; Liu, H.P.; Zhu, L.F.; Yang, X.D.; Li, J.; Ma, X.M.; Yan, T.L.; Yang, J.C.; Yuan, Y.J.; Xia, J.W.; Xu, H.S.; Xiao, G.Q.

2013-01-01

Highlights: • YAP:Ce and CsI(Tl) scintillation detectors are developed to detect heavy ions at the storage ring. • A high count rate of ∼10 7 s −1 is obtained with the YAP:Ce detector for heavy ion detection. • YAP:Ce detector shows good performance for DR experiment with 3.7 MeV/u 112 Sn 35+ . -- Abstract: The storage ring CSRm in Lanzhou provides good possibilities for electron-ion collision studies with cooled ion beams. To carry on the recombination experiment at the CSRm, a scintillation detector CsI(Tl) to detect the recombined ions was developed and tested. In addition, a YAP:Ce detector has been developed and installed at CSRm and capability of handling a high count rate of ∼10 7 s −1 has been obtained which is sufficient for the future dielectronic recombination experiment at the CSRm. The comparison of the characteristics of these two detectors is presented

Hyaluronic acid enhances cell migration and invasion via the YAP1/TAZ-RHAMM axis in malignant pleural mesothelioma.

Science.gov (United States)

Shigeeda, Wataru; Shibazaki, Masahiko; Yasuhira, Shinji; Masuda, Tomoyuki; Tanita, Tatsuo; Kaneko, Yuka; Sato, Tatsuhiro; Sekido, Yoshitaka; Maesawa, Chihaya

2017-11-07

Most malignant mesotheliomas (MPMs) frequently show activated forms of Yes-associated protein 1 (YAP1) and transcriptional co-activator with PDZ-binding motif (TAZ), which transcriptionally regulates the receptor for hyaluronic acid-mediated motility (RHAMM). As RHAMM is involved in cell migration and invasion in various tumors, we speculated that hyaluronic acid (HA) in pleural fluid might affect the progression of mesothelioma by stimulating cell migration and invasion through RHAMM. The level of RHAMM expression was decreased by YAP1/TAZ knockdown, and conversely increased by forced expression of the active form of YAP1, suggesting that RHAMM was regulated by YAP1/TAZ in MPM cells. Cell migration and invasion were also decreased by YAP1/TAZ or RHAMM knockdown. Notably, HA treatment increased cell motility and invasion, and this was abolished by RHAMM knockdown, suggesting that HA may augment local progression of MPM cells via RHAMM. Furthermore, treatment with fluvastatin, which regulates RHAMM transcription by modulating YAP1/TAZ activity, decreased the motility and invasion of MPM cells. Collectively, these data suggest that HA is an "unfavorable" factor because it promotes malignancy in mesothelioma and that the YAP1/TAZ-RHAMM axis may have potential value as a therapeutic target for inhibition of disease progression in MPM.

Study of a high gain microchannel plate photomultiplier having low statistical gain fluctuations

International Nuclear Information System (INIS)

Audier, M.

1980-12-01

A new photomultiplier configuration which synthesizes the performances of several models is proposed. The principles of microchannel plate photomultipliers are reviewed. The physical phenomena which limit the electron multiplication process in a microchannel and the detection efficiency of the microchannel plates are investigated. The operation of a herring-bone pattern device and of a system of two microchannel plate photomultipliers are described and characterized [fr

Development and characterisation of silicon photomultipliers with bulk-integrated quench resistors for future applications in particle and astroparticle physics

International Nuclear Information System (INIS)

Jendrysik, Christian

2014-01-01

This thesis deals with the development and characterisation of a novel silicon photomultiplier concept with bulk-integrated quench resistors. The approach allows the realisation of a free entrance window and high fill factors, which leads to an improvement of the detection efficiency. With first prototype productions a proof of concept was possible. A full characterisation provided promising results, in particular with respect to the photon detection efficiency. By customising the simulation tools, a reliable description of the devices was achieved. In addition, conceptual studies of the next device generation demonstrated the possibility of single cell readout, expanding the application range of those detectors to particle tracking.

Programmable electronics for low-cost small animal PET/SPECT imaging

International Nuclear Information System (INIS)

Guerra, Pedro; Rubio, Jose L.; Kontaxakis, Georgios; Ortuno, Juan E.; Ledesma, Maria J.; Santos, Andres

2006-01-01

This work describes and characterizes the detector module of a novel positron/single photon emission (PET/SPECT) scanner for small animals. This detector consists of a YAP/LSO phoswich, a photomultiplier and acquisition front-end, and will be used as building block of a low-cost hybrid tomograph. The front-end processes data sampled at a fixed frequency, where a state-of-the-art programmable device estimates scintillation pulse parameters by means of digital algorithms. Finally, the estimated properties of the proposed detector module are used to model a rotating four-head scanner. The performance of the proposed PET/SPECT scanner is estimated and first results are promising in both modalities, deserving further research and optimization

Sub-cellular localisation studies may spuriously detect the Yes-associated protein, YAP, in nucleoli leading to potentially invalid conclusions of its function.

Science.gov (United States)

Finch, Megan L; Passman, Adam M; Strauss, Robyn P; Yeoh, George C; Callus, Bernard A

2015-01-01

The Yes-associated protein (YAP) is a potent transcriptional co-activator that functions as a nuclear effector of the Hippo signaling pathway. YAP is oncogenic and its activity is linked to its cellular abundance and nuclear localisation. Activation of the Hippo pathway restricts YAP nuclear entry via its phosphorylation by Lats kinases and consequent cytoplasmic retention bound to 14-3-3 proteins. We examined YAP expression in liver progenitor cells (LPCs) and surprisingly found that transformed LPCs did not show an increase in YAP abundance compared to the non-transformed LPCs from which they were derived. We then sought to ascertain whether nuclear YAP was more abundant in transformed LPCs. We used an antibody that we confirmed was specific for YAP by immunoblotting to determine YAP's sub-cellular localisation by immunofluorescence. This antibody showed diffuse staining for YAP within the cytosol and nuclei, but, noticeably, it showed intense staining of the nucleoli of LPCs. This staining was non-specific, as shRNA treatment of cells abolished YAP expression to undetectable levels by Western blot yet the nucleolar staining remained. Similar spurious YAP nucleolar staining was also seen in mouse embryonic fibroblasts and mouse liver tissue, indicating that this antibody is unsuitable for immunological applications to determine YAP sub-cellular localisation in mouse cells or tissues. Interestingly nucleolar staining was not evident in D645 cells suggesting the antibody may be suitable for use in human cells. Given the large body of published work on YAP in recent years, many of which utilise this antibody, this study raises concerns regarding its use for determining sub-cellular localisation. From a broader perspective, it serves as a timely reminder of the need to perform appropriate controls to ensure the validity of published data.

Arsenic-induced cutaneous hyperplastic lesions are associated with the dysregulation of Yap, a Hippo signaling-related protein

International Nuclear Information System (INIS)

Li, Changzhao; Srivastava, Ritesh K.; Elmets, Craig A.; Afaq, Farrukh; Athar, Mohammad

2013-01-01

Highlights: •Arsenic activates canonical Hippo signaling pathway and up-regulates αCatenin in the skin. •Arsenic activates transcriptional activity of Yap by its nuclear translocation. •Yap is involved in the disruption of tight/adherens junctions in arsenic-exposed animals. -- Abstract: Arsenic exposure in humans causes a number of toxic manifestations in the skin including cutaneous neoplasm. However, the mechanism of these alterations remains elusive. Here, we provide novel observations that arsenic induced Hippo signaling pathway in the murine skin. This pathway plays crucial roles in determining organ size during the embryonic development and if aberrantly activated in adults, contributes to the pathogenesis of epithelial neoplasm. Arsenic treatment enhanced phosphorylation-dependent activation of LATS1 kinase and other Hippo signaling regulatory proteins Sav1 and MOB1. Phospho-LATS kinase is known to catalyze the inactivation of a transcriptional co-activator, Yap. However, in arsenic-treated epidermis, we did not observed its inactivation. Thus, as expected, unphosphorylated-Yap was translocated to the nucleus in arsenic-treated epidermis. Yap by binding to the transcription factors TEADs induces transcription of its target genes. Consistently, an up-regulation of Yap-dependent target genes Cyr61, Gli2, Ankrd1 and Ctgf was observed in the skin of arsenic-treated mice. Phosphorylated Yap is important in regulating tight and adherens junctions through its binding to αCatenin. We found disruption of these junctions in the arsenic-treated mouse skin despite an increase in αCatenin. These data provide evidence that arsenic-induced canonical Hippo signaling pathway and Yap-mediated disruption of tight and adherens junctions are independently regulated. These effects together may contribute to the carcinogenic effects of arsenic in the skin

Shikonin regulates C-MYC and GLUT1 expression through the MST1-YAP1-TEAD1 axis

Energy Technology Data Exchange (ETDEWEB)

Vališ, Karel, E-mail: karel.valis@biomed.cas.cz [Laboratory of Structural Biology and Cell Signaling, Institute of Microbiology, v.v.i., The Czech Academy of Sciences, Prague (Czech Republic); Faculty of Science, Charles University, Prague (Czech Republic); Talacko, Pavel; Grobárová, Valéria [Laboratory of Structural Biology and Cell Signaling, Institute of Microbiology, v.v.i., The Czech Academy of Sciences, Prague (Czech Republic); Faculty of Science, Charles University, Prague (Czech Republic); Černý, Jan [Faculty of Science, Charles University, Prague (Czech Republic); Novák, Petr, E-mail: pnovak@biomed.cas.cz [Laboratory of Structural Biology and Cell Signaling, Institute of Microbiology, v.v.i., The Czech Academy of Sciences, Prague (Czech Republic); Faculty of Science, Charles University, Prague (Czech Republic)

2016-12-10

The general mechanism underlying the tumor suppressor activity of the Hippo signaling pathway remains unclear. In this study, we explore the molecular mechanisms connecting the Hippo signaling pathway with glucose metabolism. We have found that two key regulators of glycolysis, C-MYC and GLUT1, are targets of the Hippo signaling pathway in human leukemia cells. Our results revealed that activation of MST1 by the natural compound shikonin inhibited the expression of GLUT1 and C-MYC. Furthermore, RNAi experiments confirmed the regulation of GLUT1 and C-MYC expression via the MST1-YAP1-TEAD1 axis. Surprisingly, YAP1 was found to positively regulate C-MYC mRNA levels in complex with TEAD1, while it negatively regulates C-MYC levels in cooperation with MST1. Hence, YAP1 serves as a rheostat for C-MYC, which is regulated by MST1. In addition, depletion of MST1 stimulates lactate production, whereas the specific depletion of TEAD1 has an opposite effect. The inhibition of lactate production and cellular proliferation induced by shikonin also depends on the Hippo pathway activity. Finally, a bioinformatic analysis revealed conserved TEAD-binding motifs in the C-MYC and GLUT1 promoters providing another molecular data supporting our observations. In summary, regulation of glucose metabolism could serve as a new tumor suppressor mechanism orchestrated by the Hippo signaling pathway. - Highlights: • Shikonin inhibits C-MYC and GLUT1 expression in MST1 and YAP1 dependent manner. • YAP1-TEAD1 interaction activates C-MYC and GLUT1 expression. • MST1 in cooperation with YAP1 inhibits C-MYC and GLUT1 expression. • MST1-YAP1-TEAD1 axis regulates lactate production by leukemic cells. • MST1 and YAP1 proteins block proliferation of leukemic cells.

Topographic and sedimentary features in the Yap subduction zone and their implications for the Caroline Ridge subduction

Science.gov (United States)

Dong, Dongdong; Zhang, Zhengyi; Bai, Yongliang; Fan, Jianke; Zhang, Guangxu

2018-01-01

The Yap subduction zone in the western Pacific presents some unique features compared to normal intra-oceanic subduction zones such as the subduction of an oceanic plateau. However, due to the relative paucity of geophysical data, the detailed structure remains unknown in this area. In this study, we present the latest high-quality swath bathymetry and multi-channel seismic data acquired synchronously in 2015 across the Yap subduction zone. The topographic and sedimentary features are intensively investigated and a modified evolutionary model of the Yap subduction zone is proposed. The two-stage evolution of the Parece Vela Basin (PVB) produced fabrics that are N-S trending and NW-SE trending. Our seismic data clearly reveal landslide deposits at the upper slope break of the forearc, to the north of the Yap Island, which was identified as the fault notch denoting a lithological boundary in previous work. The swath bathymetry and seismic profile reveal detailed horst and graben structures, including a crescent-shaped fault zone near the contact between the Yap Trench and the Caroline Ridge. A simple geometric model is proposed to explain the structure formation, indicating that the higher topography of the Caroline Ridge resulted in enhanced bending-related extension. A seismic angular unconformity (named R1) is identified in the Sorol Trough, marking the onset of rifting in the trough. Based on the sequence thickness and deposition rate by Deep Sea Drilling Project (DSDP), it is deduced that the Sorol Trough formed at 10 Ma or even earlier. A modified model for the Yap subduction zone evolution is proposed, incorporating three major tectonic events: the proto-Yap Arc rupture in the Oligocene, the collision of the Caroline Ridge and the Yap Trench in the late Oligocene or middle Miocene, and the onset of the Sorol Trough rifting in the late Miocene.

Kamu bürokrasisinde yolsuzluğun yapılaşması

OpenAIRE

CENGİZ, Mahmut

2009-01-01

“Kamu Bürokrasisinde Yolsuzluğun Yapılasması” konulu tezçalısmasında, modernitenin yükselisi ile birlikte imal edilmis risklerin enönemlilerinden kabul edilen yolsuzluğun, Türkiye kamu bürokrasisindeyapılasıp yapılasmadığını ortaya koymak için betimleyici ve açıklayıcı birçalısma yapılması amaçlanmıstır. “Uluslararası Seffaflık Örgütü”nün yapmısolduğu yolsuzluk indeksinde orta sıralarda bulunan Türkiye, yolsuzluğunulusal ve uluslararası düzeyde olumsuz sonuçlarıyla karsılasmaktadır. ...

Characterization and optimization of Silicon Photomultipliers and small size scintillator tiles for future calorimeter applications

CERN Document Server

AUTHOR|(CDS)2095312; Horváth, Ákos

For the active layers of highly granular sampling calorimeters, small scintillator tiles read out by Silicon Photomultipliers (SiPM) can be an interesting and cost effective alternative to silicon sensors. At CERN a test setup was realized for the development of new generations of calorimeters to characterize new types of Silicon Photomultipliers in terms of gain, noise, afterpulses and crosstalk and to study the impact of scintillator wrappings and the tile size on the measured light yield and uniformity. In this thesis work, the experimental setup is described and the steps for commissioning the equipment are discussed. Then, the temperature dependence of the Silicon Photomultiplier response will be investigated, including the dependence of bare Silicon Photomultipliers as well as Silicon Photomultipliers coupled to scintillator tiles. Finally, the tile-photomultiplier response for different tile sizes and coating options will be evaluated. The experimental setup will be extended to allow for the characteri...

Photomultiplier characteristics considerations for the deep underwater muon and neutrino detection system

International Nuclear Information System (INIS)

Leskovar, B.

1980-01-01

The results of an investigation of the characteristics of photomultipliers for the Deep Underwater Muon and Neutrino Detection (DUMAND) System are discussed. The pulse-height resolution, the afterpulsing phenomena and the gain sensitivity to the ambient magnetic field have been determined for large photocathode area photomultipliers. Furthermore, the transient time difference, the single photoelectron time spread, and the collection and photocathode quantum efficiency uniformity as a function of the position of the photocathode sensing area have been reviewed. Finally, an attempt has been made to estimate the photomultiplier reliability and its lifetime

Involvement of YAP, TAZ and HSP90 in contact guidance and intercellular junction formation in corneal epithelial cells.

Directory of Open Access Journals (Sweden)

Vijay Krishna Raghunathan

Full Text Available The extracellular environment possesses a rich milieu of biophysical and biochemical signaling cues that are simultaneously integrated by cells and influence cellular phenotype. Yes-associated protein (YAP and transcriptional co-activator with PDZ-binding motif (WWTR1; TAZ, two important signaling molecules of the Hippo pathway, have been recently implicated as nuclear relays of cytoskeletal changes mediated by substratum rigidity and topography. These proteins intersect with other important intracellular signaling pathways (e.g. Wnt and TGFβ. In the cornea, epithelial cells adhere to the stroma through a 3-dimensional topography-rich basement membrane, with features in the nano-submicron size-scale that are capable of profoundly modulating a wide range of fundamental cell behaviors. The influences of substratum-topography, YAP/TAZ knockdown, and HSP90 inhibition on cell morphology, YAP/TAZ localization, and the expression of TGFβ2 and CTGF, were investigated. The results demonstrate (a that knockdown of TAZ enhances contact guidance in a YAP dependent manner, (b that CTGF is predominantly regulated by YAP and not TAZ, and (c that TGFβ2 is regulated by both YAP and TAZ in these cells. Additionally, inhibition of HSP90 resulted in nuclear localization and subsequent transcriptional-activation of YAP, formation of cell-cell junctions and co-localization of E-cadherin and β-catenin at adherens junctions. Results presented in this study reflect the complexities underlying the molecular relationships between the cytoskeleton, growth factors, heat shock proteins, and co-activators of transcription that impact mechanotransduction. The data reveal the importance of YAP/TAZ on the cell behaviors, and gene and protein expression.

YAP1 Regulates OCT4 Activity and SOX2 Expression to Facilitate Self-Renewal and Vascular Mimicry of Stem-Like Cells.

Science.gov (United States)

Bora-Singhal, Namrata; Nguyen, Jonathan; Schaal, Courtney; Perumal, Deepak; Singh, Sandeep; Coppola, Domenico; Chellappan, Srikumar

2015-06-01

Non-small cell lung cancer (NSCLC) is highly correlated with smoking and has very low survival rates. Multiple studies have shown that stem-like cells contribute to the genesis and progression of NSCLC. Our results show that the transcriptional coactivator yes-associated protein 1 (YAP1), which is the oncogenic component of the Hippo signaling pathway, is elevated in the stem-like cells from NSCLC and contributes to their self-renewal and ability to form angiogenic tubules. Inhibition of YAP1 by a small molecule or depletion of YAP1 by siRNAs suppressed self-renewal and vascular mimicry of stem-like cells. These effects of YAP1 were mediated through the embryonic stem cell transcription factor, Sox2. YAP1 could transcriptionally induce Sox2 through a physical interaction with Oct4; Sox2 induction occurred independent of TEAD2 transcription factor, which is the predominant mediator of YAP1 functions. The binding of Oct4 to YAP1 could be detected in cell lines as well as tumor tissues; the interaction was elevated in NSCLC samples compared to normal tissue as seen by proximity ligation assays. YAP1 bound to Oct4 through the WW domain, and a peptide corresponding to this region could disrupt the interaction. Delivery of the WW domain peptide to stem-like cells disrupted the interaction and abrogated Sox2 expression, self-renewal, and vascular mimicry. Depleting YAP1 reduced the expression of multiple epithelial-mesenchymal transition genes and prevented the growth and metastasis of tumor xenografts in mice; overexpression of Sox2 in YAP1 null cells rescued these functions. These results demonstrate a novel regulation of stem-like functions by YAP1, through the modulation of Sox2 expression. © 2015 AlphaMed Press.

Cherenkov TOF PET with silicon photomultipliers

Science.gov (United States)

Dolenec, R.; Korpar, S.; Križan, P.; Pestotnik, R.

2015-12-01

As previously demonstrated, an excellent timing resolution below 100 ps FWHM is possible in time-of-flight positron emission tomography (TOF PET) if the detection method is based on the principle of detecting photons of Cherenkov light, produced in a suitable material and detected by microchannel plate photomultipliers (MCP PMTs). In this work, the silicon photomultipliers (SiPMs) were tested for the first time as the photodetectors in Cherenkov TOF PET. The high photon detection efficiency (PDE) of SiPMs led to a large improvement in detection efficiency. On the other hand, the time response of currently available SiPMs is not as good as that of MCP PMTs. The SiPM dark counts introduce a new source of random coincidences in Cherenkov method, which would be overwhelming with present SiPM technology at room temperature. When the apparatus was cooled, its performance significantly improved.

Model independent approach to the single photoelectron calibration of photomultiplier tubes

Energy Technology Data Exchange (ETDEWEB)

Saldanha, R.; Grandi, L.; Guardincerri, Y.; Wester, T.

2017-08-01

The accurate calibration of photomultiplier tubes is critical in a wide variety of applications in which it is necessary to know the absolute number of detected photons or precisely determine the resolution of the signal. Conventional calibration methods rely on fitting the photomultiplier response to a low intensity light source with analytical approximations to the single photoelectron distribution, often leading to biased estimates due to the inability to accurately model the full distribution, especially at low charge values. In this paper we present a simple statistical method to extract the relevant single photoelectron calibration parameters without making any assumptions about the underlying single photoelectron distribution. We illustrate the use of this method through the calibration of a Hamamatsu R11410 photomultiplier tube and study the accuracy and precision of the method using Monte Carlo simulations. The method is found to have significantly reduced bias compared to conventional methods and works under a wide range of light intensities, making it suitable for simultaneously calibrating large arrays of photomultiplier tubes.

Silicon Photomultipliers (SiPM) as novel photodetectors for PET

International Nuclear Information System (INIS)

Del Guerra, Alberto; Belcari, Nicola; Giuseppina Bisogni, Maria; Corsi, Francesco; Foresta, Maurizio; Guerra, Pedro; Marcatili, Sara; Santos, Andres; Sportelli, Giancarlo

2011-01-01

Next generation PET scanners should fulfill very high requirements in terms of spatial, energy and timing resolution. Modern scanner performances are inherently limited by the use of standard photomultiplier tubes. The use of Silicon Photomultipliers (SiPMs) is proposed for the construction of a 4D-PET module of 4.8x4.8 cm 2 aimed to replace the standard PMT based PET block detector. The module will be based on a LYSO continuous crystal read on two faces by Silicon Photomultipliers. A high granularity detection surface made by SiPM matrices of 1.5 mm pitch will be used for the x-y photon hit position determination with submillimetric accuracy, while a low granularity surface constituted by 16 mm 2 SiPM pixels will provide the fast timing information (t) that will be used to implement the Time of Flight technique (TOF). The spatial information collected by the two detector layers will be combined in order to measure the Depth of Interaction (DOI) of each event (z). The use of large area multi-pixel Silicon Photomultiplier (SiPM) detectors requires the development of a multichannel Data Acquisition system (DAQ) as well as of a dedicated front-end in order not to degrade the intrinsic detector capabilities and to manage many channels. The paper describes the progress made on the development of the proof of principle module under construction at the University of Pisa.

Activation of the oxidative stress regulator PpYap1 through conserved cysteine residues during methanol metabolism in the yeast Pichia pastoris.

Science.gov (United States)

Yano, Taisuke; Yurimoto, Hiroya; Sakai, Yasuyoshi

2009-06-01

The methylotrophic yeast Pichia pastoris can grow on methanol as sole source of carbon and energy. The first reaction in yeast methanol metabolism, catalyzed by an abundant peroxisomal enzyme, alcohol oxidase, generates high levels of H(2)O(2), but the oxidative stress response during methanol metabolism has not been elucidated. In this study, we isolated the Yap1 homolog of P. pastoris (PpYap1) and analyzed the properties of a PpYAP1-disruption strain. The PpYap1 transcription factor is activated after exposure to various reactive agents, and therefore functions as a regulator of the redox system in P. pastoris. We have also identified PpGPX1, the unique glutathione peroxidase-encoding gene in P. pastoris whose expression is induced by PpYap1. PpGpx1, but not the ScTsa1 or SpTpx1 homolog PpTsa1, functions as a H(2)O(2) sensor and activates PpYap1. This study is the first demonstration of a yeast Yap1 family protein activated during conventional metabolism.

Fabrication, characterization and testing of silicon photomultipliers for the Muon Portal Project

International Nuclear Information System (INIS)

La Rocca, P.; Billotta, S.; Blancato, A.A.; Bonanno, D.; Bonanno, G.; Fallica, G.; Garozzo, S.; Lo Presti, D.; Marano, D.; Pugliatti, C.; Riggi, F.; Romeo, G.; Santagati, G.; Valvo, G.

2015-01-01

The Muon Portal is a recently started Project aiming at the construction of a large area tracking detector that exploits the muon tomography technique to inspect the contents of traveling cargo containers. The detection planes will be made of plastic scintillator strips with embedded wavelength-shifting fibres. Special designed silicon photomultipliers will read the scintillation light transported by the fibres along the strips and a dedicated electronics will combine signals from different strips to reduce the overall number of channels, without loss of information. Different silicon photomultiplier prototypes, both with the p-on-n and n-on-p technologies, have been produced by STMicroelectronics during the last years. In this paper we present the main characteristics of the silicon photomultipliers designed for the Muon Portal Project and describe the setup and the procedure implemented for the characterization of these devices, giving some statistical results obtained from the test of a first batch of silicon photomultipliers

Fabrication, characterization and testing of silicon photomultipliers for the Muon Portal Project

Energy Technology Data Exchange (ETDEWEB)

La Rocca, P., E-mail: paola.larocca@ct.infn.it [Dipartimento di Fisica e Astronomia - Catania (Italy); INFN - Sezione di Catania (Italy); Billotta, S. [INAF - Osservatorio Astrofisico di Catania (Italy); Blancato, A.A.; Bonanno, D. [Dipartimento di Fisica e Astronomia - Catania (Italy); Bonanno, G. [INAF - Osservatorio Astrofisico di Catania (Italy); Fallica, G. [STMicroelectronics - Catania (Italy); Garozzo, S. [INAF - Osservatorio Astrofisico di Catania (Italy); Lo Presti, D. [Dipartimento di Fisica e Astronomia - Catania (Italy); INFN - Sezione di Catania (Italy); Marano, D. [INAF - Osservatorio Astrofisico di Catania (Italy); Pugliatti, C.; Riggi, F. [Dipartimento di Fisica e Astronomia - Catania (Italy); INFN - Sezione di Catania (Italy); Romeo, G. [INAF - Osservatorio Astrofisico di Catania (Italy); Santagati, G. [Dipartimento di Fisica e Astronomia - Catania (Italy); INFN - Sezione di Catania (Italy); Valvo, G. [STMicroelectronics - Catania (Italy)

2015-07-01

The Muon Portal is a recently started Project aiming at the construction of a large area tracking detector that exploits the muon tomography technique to inspect the contents of traveling cargo containers. The detection planes will be made of plastic scintillator strips with embedded wavelength-shifting fibres. Special designed silicon photomultipliers will read the scintillation light transported by the fibres along the strips and a dedicated electronics will combine signals from different strips to reduce the overall number of channels, without loss of information. Different silicon photomultiplier prototypes, both with the p-on-n and n-on-p technologies, have been produced by STMicroelectronics during the last years. In this paper we present the main characteristics of the silicon photomultipliers designed for the Muon Portal Project and describe the setup and the procedure implemented for the characterization of these devices, giving some statistical results obtained from the test of a first batch of silicon photomultipliers.

Kahramanmaraş İlindeki Tekstil Firmalarının Dış Ticaret Yapısı

OpenAIRE

AKBAY, Cuma; DOĞAROĞLU, Sibel

2016-01-01

Bu araştırmada Kahramanmaraş ilinde faaliyet gösteren tekstil firmalarının dış ticaret yapısı incelenerek mevcut yapının ortaya konulması yanında; işletmelerin dış ticaret yapısının büyüklüklerini doğrudan nasıl etkilediğinin, işletmelerin dış ticaret yapısı ve Kahramanmaraş ilinde tekstil firmalarında ithalat-ihracat işlemlerinin profesyonel durumunun, dış ticaret biriminin öneminin, dış ticarette ihtiyaç duyulan bilgilerin, işletmelerin geçmiş yıllarda dış ticarette karşılaşmış olduğu sorun...

Self-mode-locking operation of a diode-end-pumped Tm:YAP laser with watt-level output power

Science.gov (United States)

Zhang, Su; Zhang, Xinlu; Huang, Jinjer; Wang, Tianhan; Dai, Junfeng; Dong, Guangzong

2018-03-01

We report on a high power continuous wave (CW) self-mode-locked Tm:YAP laser pumped by a 792 nm laser diode. Without any additional mode-locking elements in the cavity, stable and self-starting mode-locking operation has been realized. The threshold pump power of the CW self-mode-locked Tm:YAP laser is only 5.4 W. The maximum average output power is as high as 1.65 W at the pump power of 12 W, with the repetition frequency of 468 MHz and the center wavelength of 1943 nm. To the best of our knowledge, this is the first CW self-mode-locked Tm:YAP laser. The experiment results show that the Tm:YAP crystal is a promising gain medium for realizing the high power self-mode-locking operation at 2 µm.

YAP(Ce) crystal characterization with proton beam up to 60 MeV

Energy Technology Data Exchange (ETDEWEB)

Randazzo, N. [Istituto Nazionale di Fisica Nucleare, Sezione di Catania (I), Via S. Sofia, 64-I-95123 Catania (Italy)], E-mail: nunzio.randazzo@ct.infn.it; Sipala, V.; Aiello, S. [Istituto Nazionale di Fisica Nucleare, Sezione di Catania (I), Via S. Sofia, 64-I-95123 Catania (Italy); Lo Presti, D. [Istituto Nazionale di Fisica Nucleare, Sezione di Catania (I), Via S. Sofia, 64-I-95123 Catania (Italy); Dipartimento di Fisica e Astronomia, Universita di Catania, Catania (Italy); Cirrone, G.A.P.; Cuttone, G.; Di Rosa, F. [Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali del Sud (Italy)

2008-02-21

A YAP(Ce) crystal was characterized with a proton beam up to 60 MeV. Tests were performed to investigate the possibility of using this detector as a proton calorimeter. The size of the crystal was chosen so that the proton energy is totally lost inside the medium. The authors propose to use the YAP(Ce) crystal in medical applications for proton therapy. In particular, in proton computed tomography (pCT) project it is necessary as a calorimeter in order to measure the proton residual energy after the phantom. Energy resolution, linearity, and light yield were measured in the Laboratori Nazionali del Sud with the CATANA proton beam [ (http://www.lns.infn.it/CATANA/CATANA)] and the results are shown in this paper. The crystal shows a good resolution (3% at 60 MeV proton beam) and it shows good linearity for different proton beam energies (1% at 30-60 MeV energy range). The crystal performances confirm that the YAP(Ce) crystal represents a good solution for these kinds of application.

YAP(Ce) crystal characterization with proton beam up to 60 MeV

International Nuclear Information System (INIS)

Randazzo, N.; Sipala, V.; Aiello, S.; Lo Presti, D.; Cirrone, G.A.P.; Cuttone, G.; Di Rosa, F.

2008-01-01

A YAP(Ce) crystal was characterized with a proton beam up to 60 MeV. Tests were performed to investigate the possibility of using this detector as a proton calorimeter. The size of the crystal was chosen so that the proton energy is totally lost inside the medium. The authors propose to use the YAP(Ce) crystal in medical applications for proton therapy. In particular, in proton computed tomography (pCT) project it is necessary as a calorimeter in order to measure the proton residual energy after the phantom. Energy resolution, linearity, and light yield were measured in the Laboratori Nazionali del Sud with the CATANA proton beam [ (http://www.lns.infn.it/CATANA/CATANA)] and the results are shown in this paper. The crystal shows a good resolution (3% at 60 MeV proton beam) and it shows good linearity for different proton beam energies (1% at 30-60 MeV energy range). The crystal performances confirm that the YAP(Ce) crystal represents a good solution for these kinds of application

YAP(Ce) crystal characterization with proton beam up to 60 MeV

Science.gov (United States)

Randazzo, N.; Sipala, V.; Aiello, S.; Lo Presti, D.; Cirrone, G. A. P.; Cuttone, G.; Di Rosa, F.

2008-02-01

A YAP(Ce) crystal was characterized with a proton beam up to 60 MeV. Tests were performed to investigate the possibility of using this detector as a proton calorimeter. The size of the crystal was chosen so that the proton energy is totally lost inside the medium. The authors propose to use the YAP(Ce) crystal in medical applications for proton therapy. In particular, in proton computed tomography (pCT) project it is necessary as a calorimeter in order to measure the proton residual energy after the phantom. Energy resolution, linearity, and light yield were measured in the Laboratori Nazionali del Sud with the CATANA proton beam [ http://www.lns.infn.it/CATANA/CATANA] and the results are shown in this paper. The crystal shows a good resolution (3% at 60 MeV proton beam) and it shows good linearity for different proton beam energies (1% at 30-60 MeV energy range). The crystal performances confirm that the YAP(Ce) crystal represents a good solution for these kinds of application.

Automatic test system of the photomultipliers

International Nuclear Information System (INIS)

Shiino, Kazuo; Kono, Koji; Ishii, Takanobu; Kasai, Seiji; Yamada, Sakue; Kitamura, Shoichi.

1990-03-01

A test system of R580 photomultipliers (PMTs) was constructed for the ZEUS experiment HERA. In this report, we will describe the general feature of the test system, each component of the setup, the procedure of the measurements, the data analyses and the results of the first 800 PMT measurements. (author)

A hybrid degradation tendency measurement method for mechanical equipment based on moving window and Grey–Markov model

International Nuclear Information System (INIS)

Jiang, Wei; Zhou, Jianzhong; Zheng, Yang; Liu, Han

2017-01-01

Accurate degradation tendency measurement is vital for the secure operation of mechanical equipment. However, the existing techniques and methodologies for degradation measurement still face challenges, such as lack of appropriate degradation indicator, insufficient accuracy, and poor capability to track the data fluctuation. To solve these problems, a hybrid degradation tendency measurement method for mechanical equipment based on a moving window and Grey–Markov model is proposed in this paper. In the proposed method, a 1D normalized degradation index based on multi-feature fusion is designed to assess the extent of degradation. Subsequently, the moving window algorithm is integrated with the Grey–Markov model for the dynamic update of the model. Two key parameters, namely the step size and the number of states, contribute to the adaptive modeling and multi-step prediction. Finally, three types of combination prediction models are established to measure the degradation trend of equipment. The effectiveness of the proposed method is validated with a case study on the health monitoring of turbine engines. Experimental results show that the proposed method has better performance, in terms of both measuring accuracy and data fluctuation tracing, in comparison with other conventional methods. (paper)

A hybrid degradation tendency measurement method for mechanical equipment based on moving window and Grey-Markov model

Science.gov (United States)

Jiang, Wei; Zhou, Jianzhong; Zheng, Yang; Liu, Han

2017-11-01

Accurate degradation tendency measurement is vital for the secure operation of mechanical equipment. However, the existing techniques and methodologies for degradation measurement still face challenges, such as lack of appropriate degradation indicator, insufficient accuracy, and poor capability to track the data fluctuation. To solve these problems, a hybrid degradation tendency measurement method for mechanical equipment based on a moving window and Grey-Markov model is proposed in this paper. In the proposed method, a 1D normalized degradation index based on multi-feature fusion is designed to assess the extent of degradation. Subsequently, the moving window algorithm is integrated with the Grey-Markov model for the dynamic update of the model. Two key parameters, namely the step size and the number of states, contribute to the adaptive modeling and multi-step prediction. Finally, three types of combination prediction models are established to measure the degradation trend of equipment. The effectiveness of the proposed method is validated with a case study on the health monitoring of turbine engines. Experimental results show that the proposed method has better performance, in terms of both measuring accuracy and data fluctuation tracing, in comparison with other conventional methods.

Structure of a 14-3-3σ–YAP phosphopeptide complex at 1.15 Å resolution

International Nuclear Information System (INIS)

Schumacher, Benjamin; Skwarczynska, Malgorzata; Rose, Rolf; Ottmann, Christian

2010-01-01

The first structure of a 14-3-3 protein–phosphopeptide complex is reported at 1.15 Å resolution. The YAP 14-3-3-binding motif is revealed for the first time using crystallographic tools. The 14-3-3 proteins are a class of eukaryotic acidic adapter proteins, with seven isoforms in humans. 14-3-3 proteins mediate their biological function by binding to target proteins and influencing their activity. They are involved in pivotal pathways in the cell such as signal transduction, gene expression, enzyme activation, cell division and apoptosis. The Yes-associated protein (YAP) is a WW-domain protein that exists in two transcript variants of 48 and 54 kDa in humans. By transducing signals from the cytoplasm to the nucleus, YAP is important for transcriptional regulation. In both variants, interaction with 14-3-3 proteins after phosphorylation of Ser127 is important for nucleocytoplasmic trafficking, via which the localization of YAP is controlled. In this study, 14-3-3σ has been cloned, purified and crystallized in complex with a phosphopeptide from the YAP 14-3-3-binding domain, which led to a crystal that diffracted to 1.15 Å resolution. The crystals belonged to space group C222 1 , with unit-cell parameters a = 82.3, b = 112.1, c = 62.9 Å

Normal hematopoietic stem cell function in mice with enforced expression of the Hippo signaling effector YAP1.

Directory of Open Access Journals (Sweden)

Lina Jansson

Full Text Available The Hippo pathway has recently been implicated in the regulation of organ size and stem cells in multiple tissues. The transcriptional cofactor yes-associated protein 1 (Yap1 is the most downstream effector of Hippo signaling and is functionally repressed by the upstream components of the pathway. Overexpression of YAP1 stimulates proliferation of stem and progenitor cells in many tissues, consistent with inhibition of Hippo signaling. To study the role of Hippo signaling in hematopoietic stem cells (HSCs, we created a transgenic model with inducible YAP1 expression exclusively within the hematopoietic system. Following 3 months induction, examination of blood and bone marrow in the induced mice revealed no changes in the distribution of the hematopoietic lineages compared to control mice. Moreover, the progenitor cell compartment was unaltered as determined by colony forming assays and immunophenotyping. To address whether YAP1 affects the quantity and function of HSCs we performed competitive transplantation experiments. We show that ectopic YAP1 expression does not influence HSC function neither during steady state nor in situations of hematopoietic stress. This is in sharp contrast to effects seen on stem- and progenitor cells in other organs and suggests highly tissue specific functions of the Hippo pathway in regulation of stem cells.

A small animal PET prototype based on Silicon Photomultipliers

International Nuclear Information System (INIS)

Marcatili, S; Belcari, N.; Bisogni, M.G.; Del Guerra, A.; Collazuol, G.; Pedreschi, E.; Spinella, F.; Sportelli, G.; Marzocca, C.

2011-01-01

Next generation PET scanners should full fill very high requirements in terms of spatial, energy and timing resolution. Modern scanner performances are inherently limited by the use of standard photomultiplier tubes. The use of Silicon Photomultiplier (Si P M) matrices is proposed for the construction of a small animal PET system consisting of two detector heads based on Lyso continuos crystals. The use of large area multi-pixel Silicon Photomultiplier (Si P M) detectors requires the development of a multichannel Digital Acquisition system (DAQ) as well as of a dedicated front-end in order not to degrade the intrinsic detector capabilities. At the University of Pisa and INFN Pisa we developed a DAQ board for the read-out of 2 64-pixel Si P M matrices in time coincidence for Positron Emission Tomography (PET) applications. The proof of principles is based on 64-pixel detectors, but the whole system has been conceived to be easily scalable to a higher number of channels. Here we describe the Group-V INFN DASi P M 2 (Development and Application of Si P M) project and related results.

A new detector concept for silicon photomultipliers

Energy Technology Data Exchange (ETDEWEB)

Sadigov, A., E-mail: saazik@yandex.ru [National Nuclear Research Center, Baku (Azerbaijan); Ahmadov, F.; Ahmadov, G. [National Nuclear Research Center, Baku (Azerbaijan); Ariffin, A.; Khorev, S. [Zecotek Photonics Inc., Vancouver (Canada); Sadygov, Z. [National Nuclear Research Center, Baku (Azerbaijan); Joint Institute for Nuclear Research, Dubna (Russian Federation); Suleymanov, S. [National Nuclear Research Center, Baku (Azerbaijan); Zerrouk, F. [Zecotek Photonics Inc., Vancouver (Canada); Madatov, R. [Institute of Radiation Problems, Baku (Azerbaijan)

2016-07-11

A new design and principle of operation of silicon photomultipliers are presented. The new design comprises a semiconductor substrate and an array of independent micro-phototransistors formed on the substrate. Each micro-phototransistor comprises a photosensitive base operating in Geiger mode and an individual micro-emitter covering a small part of the base layer, thereby creating, together with this latter, a micro-transistor. Both micro-emitters and photosensitive base layers are connected with two respective independent metal grids via their individual micro-resistors. The total value of signal gain in the proposed silicon photomultiplier is a result of both the avalanche gain in the base layer and the corresponding gain in the micro-transistor. The main goals of the new design are: significantly lower both optical crosstalk and after-pulse effects at high signal amplification, improve speed of single photoelectron pulse formation, and significantly reduce the device capacitance.

Fast photomultiplier ELUP 151

International Nuclear Information System (INIS)

Andreeva, L.I.; Belokon', V.A.; Krasin, E.V.

1992-01-01

High-velocity photomultiplier is described. The latter is recommended to be used in nuclear physics, plasma physics, nuclear medical diagnostics and at measurement of fast-occurring process parameters. Main specifications are as follows: range of spectral sensitivity - 0.2-0.7 μm; limit of dinamic characteristic linearity - up to 5A; dark current at +20 deg C ambient temperature - maximum 10-8A, time of anode pulse growth - maximum 8 ns; photocathode quantum yield in the maximum of spectral characteristic (λ max =380-420 nm) - 24-26%; supply voltage - 4-5 kV

Estimation of Fano factor in inorganic scintillators

Energy Technology Data Exchange (ETDEWEB)

Bora, Vaibhav, E-mail: bora.vaibhav@gmail.com [Center for Gamma-Ray Imaging, Department of Medical Imaging, University of Arizona and College of Optical Sciences, University of Arizona, Tucson, AZ 85724 (United States); Barrett, Harrison H., E-mail: barrett@radiology.arizona.edu [Center for Gamma-Ray Imaging, Department of Medical Imaging, University of Arizona and College of Optical Sciences, University of Arizona, Tucson, AZ 85724 (United States); Fastje, David, E-mail: dfastje@gmail.com [Center for Gamma-Ray Imaging, Department of Medical Imaging, University of Arizona and College of Optical Sciences, University of Arizona, Tucson, AZ 85724 (United States); Clarkson, Eric, E-mail: clarkson@radiology.arizona.edu [Center for Gamma-Ray Imaging, Department of Medical Imaging, University of Arizona and College of Optical Sciences, University of Arizona, Tucson, AZ 85724 (United States); Furenlid, Lars, E-mail: furen@radiology.arizona.edu [Center for Gamma-Ray Imaging, Department of Medical Imaging, University of Arizona and College of Optical Sciences, University of Arizona, Tucson, AZ 85724 (United States); Bousselham, Abdelkader, E-mail: abousselham@qf.org.qa [Qatar Foundation, QEERI, P.O. Box 5825, Doha (Qatar); Shah, Kanai S., E-mail: kanaishah@yahoo.com [Radiation Monitoring Devices, Inc., Watertown, MA 02472 (United States); Glodo, Jarek, E-mail: jglodo@rmdinc.com [Radiation Monitoring Devices, Inc., Watertown, MA 02472 (United States)

2016-01-01

The Fano factor of an integer-valued random variable is defined as the ratio of its variance to its mean. Correlation between the outputs of two photomultiplier tubes on opposite faces of a scintillation crystal was used to estimate the Fano factor of photoelectrons and scintillation photons. Correlations between the integrals of the detector outputs were used to estimate the photoelectron and photon Fano factor for YAP:Ce, SrI{sub 2}:Eu and CsI:Na scintillator crystals. At 662 keV, SrI{sub 2}:Eu was found to be sub-Poisson, while CsI:Na and YAP:Ce were found to be super-Poisson. An experiment setup inspired from the Hanbury Brown and Twiss experiment was used to measure the correlations as a function of time between the outputs of two photomultiplier tubes looking at the same scintillation event. A model of the scintillation and the detection processes was used to generate simulated detector outputs as a function of time for different values of Fano factor. The simulated outputs from the model for different Fano factors was compared to the experimentally measured detector outputs to estimate the Fano factor of the scintillation photons for YAP:Ce, LaBr{sub 3}:Ce scintillator crystals. At 662 keV, LaBr{sub 3}:Ce was found to be sub-Poisson, while YAP:Ce was found to be close to Poisson.

Accuracy of single photoelectron time spread measurement of fast photomultipliers

International Nuclear Information System (INIS)

Leskovar, B.

1975-01-01

The accuracy of time spread measurements of fast photomultipliers was investigated, using single photoelectrons. The effect of the finite light pulse width on the measurement accuracy was determined and discussed. Experimental data were obtained on a special measuring system for light pulse widths ranging from 200 psec to 10 nsec, using fast photomultipliers 8850 and C31024 with optimized operating conditions for minimum transit time spread. A modified exponential function expression and curve-fitting parameters are given, which fit closely the experimentally obtained data over a wide dynamic range of light pulse widths. (U.S.)

YAP scintillators for resonant detection of epithermal neutrons at pulsed neutron sources

International Nuclear Information System (INIS)

Tardocchi, M.; Gorini, G.; Pietropaolo, A.; Andreani, C.; Senesi, R.; Rhodes, N.; Schooneveld, E. M.

2004-01-01

Recent studies indicate the resonance detector (RD) technique as an interesting approach for neutron spectroscopy in the electron volt energy region. This work summarizes the results of a series of experiments where RD consisting of YAlO 3 (YAP) scintillators were used to detect scattered neutrons with energy in the range 1-200 eV. The response of YAP scintillators to radiative capture γ emission from a 238 U analyzer foil was characterized in a series of experiments performed on the VESUVIO spectrometer at the ISIS pulsed neutron source. In these experiments a biparametric data acquisition allowed the simultaneous measurements of both neutron time-of-flight and γ pulse height (energy) spectra. The analysis of the γ pulse height and neutron time of flight spectra permitted to identify and distinguish the signal and background components. These measurements showed that a significant improvement in the signal-to-background ratio can be achieved by setting a lower level discrimination on the pulse height at about 600 keV equivalent photon energy. Present results strongly indicate YAP scintillators as the ideal candidate for neutron scattering studies with epithermal neutrons at both very low (<5 deg.) and intermediate scattering angles

Piezoelectrically and triboelectrically hybridized self-powered sensor with applications to smart window and human motion detection

Directory of Open Access Journals (Sweden)

Yiin-Kuen Fuh

2017-07-01

Full Text Available In this paper, we demonstrate a hybrid generator, derived from the concurrent adoption of piezoelectric and triboelectric mechanisms in one press-and-release cycle, called a Hybridized Self-Powered sensor (HSPS. A new integration of print circuit board (PCB technology-based piezoelectric generator (PG concurrently adopted the direct-write, near-field electrospun polyvinylidene fluoride (PVDF nano/micro-fibers as piezoelectric source materials. On the other hand, triboelectric nanogenerators have the advantages of a high output performance with a simple structure which is also concurrently combined with the PG. The working mechanism of the HSPS includes the PCB-based substrate mounted with parallel aligned piezoelectric PVDF fibers in planar configuration which first bended and generated the electric potential via the effect of piezoelectricity. In what follows, the deformation of a cylindrical rolled-up piezoelectric structure is exercised, and finally, the triboelectric contact of Cu and PTFE layers is physically rubbed against each other with a separation to induce the triboelectric potential. This hybridized generator with a double domed shape design simultaneously combines piezoelectric output and triboelectric output and offers a built-in spacer with automatically spring back capability, which produces a peak output voltage of 100 V, a current of 4 μA, and a maximum power output of 450 nW. A self-powered smart window system was experimentally driven through finger-induced strain of HSPS, showing the optical properties with reversibly tunable transmittances. This research is a substantial advancement in the field of piezoelectric PVDF fibers integration toward the practical application of the whole self-powered system.

Piezoelectrically and triboelectrically hybridized self-powered sensor with applications to smart window and human motion detection

Science.gov (United States)

Fuh, Yiin-Kuen; Li, Shan-Chien; Chen, Chun-Yu

2017-07-01

In this paper, we demonstrate a hybrid generator, derived from the concurrent adoption of piezoelectric and triboelectric mechanisms in one press-and-release cycle, called a Hybridized Self-Powered sensor (HSPS). A new integration of print circuit board (PCB) technology-based piezoelectric generator (PG) concurrently adopted the direct-write, near-field electrospun polyvinylidene fluoride (PVDF) nano/micro-fibers as piezoelectric source materials. On the other hand, triboelectric nanogenerators have the advantages of a high output performance with a simple structure which is also concurrently combined with the PG. The working mechanism of the HSPS includes the PCB-based substrate mounted with parallel aligned piezoelectric PVDF fibers in planar configuration which first bended and generated the electric potential via the effect of piezoelectricity. In what follows, the deformation of a cylindrical rolled-up piezoelectric structure is exercised, and finally, the triboelectric contact of Cu and PTFE layers is physically rubbed against each other with a separation to induce the triboelectric potential. This hybridized generator with a double domed shape design simultaneously combines piezoelectric output and triboelectric output and offers a built-in spacer with automatically spring back capability, which produces a peak output voltage of 100 V, a current of 4 μA, and a maximum power output of 450 nW. A self-powered smart window system was experimentally driven through finger-induced strain of HSPS, showing the optical properties with reversibly tunable transmittances. This research is a substantial advancement in the field of piezoelectric PVDF fibers integration toward the practical application of the whole self-powered system.

Photomultiplier tube having a plurality of sensing areas

International Nuclear Information System (INIS)

1976-01-01

A single photomultiplier tube having four sensing areas each of which produces its own independent electrical signal that is related to the quantity of sensed matter that impinges on its area is described

Mediator, SWI/SNF and SAGA complexes regulate Yap8-dependent transcriptional activation of ACR2 in response to arsenate.

Science.gov (United States)

Menezes, Regina Andrade; Pimentel, Catarina; Silva, Ana Rita Courelas; Amaral, Catarina; Merhej, Jawad; Devaux, Frédéric; Rodrigues-Pousada, Claudina

2017-04-01

Response to arsenic stress in Saccharomyces cerevisiae is orchestrated by the regulatory protein Yap8, which mediates transcriptional activation of ACR2 and ACR3. This study contributes to the state of art knowledge of the molecular mechanisms underlying yeast stress response to arsenate as it provides the genetic and biochemical evidences that Yap8, through cysteine residues 132, 137, and 274, is the sensor of presence of arsenate in the cytosol. Moreover, it is here reported for the first time the essential role of the Mediator complex in the transcriptional activation of ACR2 by Yap8. Based on our data, we propose an order-of-function map to recapitulate the sequence of events taking place in cells injured with arsenate. Modification of the sulfhydryl state of these cysteines converts Yap8 in its activated form, triggering the recruitment of the Mediator complex to the ACR2/ACR3 promoter, through the interaction with the tail subunit Med2. The Mediator complex then transfers the regulatory signals conveyed by Yap8 to the core transcriptional machinery, which culminates with TBP occupancy, ACR2 upregulation and cell adaptation to arsenate stress. Additional co-factors are required for the transcriptional activation of ACR2 by Yap8, particularly the nucleosome remodeling activity of SWI/SNF and SAGA complexes. Copyright © 2017. Published by Elsevier B.V.

Characterisation of the Hamamatsu photomultipliers for the KM3NeT Neutrino Telescope

NARCIS (Netherlands)

Aiello, S.; Akrame, S.E.; Amélineau, F.; Anassontzis, E.G.; Andre, M.; Androulakis, G.; Anghinolfi; Anton, G.; Ardid, M.; Aublin, J.; Avgitas, T.; Baars, M.; Bagatelas, C.; Barbarino, G.; Baret, B.; Barrios-Martí, J.; Belias, A.; Berbee, E.; van den Berg, A.; Bertin, V.; Biagi, S.; Biagioni, A.; Biernoth, C.; Bormuth, R.; Boumaaza, J.; Bourret, S.; Bouwhuis, M.; Bozza, C.; Brânzas, H.; Briukhanova, N.; Bruijn, R.; Brunner, J.; Buis, E.; Buompane, R,; Busto, J.; Calvo, D.; Capone, A.; Caramete, L.; Celli, S.; Chabab, M.; Cherubini, S.; Chiarella, V.; Chiarusi, T.; Circella, M.; Cocimano, R.; Coelho, J.A.B.; Coleiro, A.; Molla, M.C.; Coniglione, R.; Coyle, P.; Creusot, A.; Cuttone, G.; D’Onofrio, A.; Dallier, R.; De Sio, C.; Di Palma, I.; Díaz, A.F.; Distefano, C.; Domi, A.; Donà, R.; Donzaud, C.; Dornic, D.; Dörr, M.; Durocher, M.; Eberl, T.; Van Eijk, D.; El Bojaddaini, I.; Elsaesser, D.; Enzenhöfer, A.; Ferrara, G.; Fusco, L.A.; Gal, T.; Garufi, F.; Gauchery, S.; Geißelsöder, S.; Gialanella, L.; Giorgio, E.; Giuliante, A.; Gozzini, S.R.; Gracia-Ruiz, R.; Graf, K.; Grasso, D.; Grégoire, T.; Grella, G.; Hallmann, S.; van Haren, H.; Heid, T.; Heijboer, A.; Hekalo, A.; Hernandez-Rey, J.J.; Hofestädt, J.; Illuminati, G.; James, C.W.; Jongen, M.; Jongewaard, B.; de Jong, M.; de Jong, P.; Kadler, M.; Kalaczynski, P.; Kalekin, O.; Katz, U.F.; Khan Chowdhury, N.R.; Kieft, G.; Kießling, D.; Koffeman, E.N.; Kooijman, P.; Kouchner, A.; Kreter, M.; Kulikovskiy, V.; Lahmann, R.; Le Breton, A.; Leone, F.; Leonora, E.; Levi, G.; Lincetto, M.; Lonardo, A.; Longhitano, F.; Lotze, M.; Loucatos, S.; Maggi, G.; Manczak, J.; Mannheim, K.; Margiotta, A.; Marinelli, A.; Markou, C.; Martin, L.; Martínez-Mora, J.A.; Martini, A.; Marzaioli, F.; Mele, R.; Melis, K.W.; Migliozzi, P.; Migneco, E.; Mijakowski, P.; Mollo, C.M.; Morganti, M.; Moser, M.; Moussa, A.; Muller, R.; Musumeci, M.; Nauta, L.; Navas, S.; Nicolau, C.A.; Nielsen, C.; Organokov, M.; Orlando, A.; Panagopoulos, V.; Papalashvili, G.; Papaleo, R.; Pavalas, G.E.; Pellegrini, G.; Pellegrino, C.; Pérez Romero, J.; Perrin-Terrin, M.; Piattelli, P.; Pikounis, K.; Pisanti, O.; Poirè, C.; Polydefki, G.; Poma, G.E.; Popa, V.; Post, M.; Pradier, T.; Pühlhofer, G.; Pulvirenti, S.; Quinn, L.; Raffaelli, F.; Randazzo, N.; Razzaque, S.; Real, D.; Resvanis, L.; Reubelt, J.; Riccobene, G.; Richer, M.; Rovelli, A.; Salvadori, I.; Samtleben, D.F.E.; Sánchez-Losa, A.; Sanguineti, M.; Santangelo, A.; Sapienza, P.; Schermer, B.; Sciacca, V.; Seneca, J.; Sgura, I.; Shanidze, R.; Sharma, A.; Simeone, F.; Sinopoulou, A.; Spisso, B.; Spurio, M.; Stavropoulos, D.; Steijger, J.; Stellacci, S.M.; Strandberg, B.; Stransky, D.; Stüven, T.; Taiuti, M.; Tatone, F.; Tayalati, Y.; Tenllado, E.; Thakore, T.; Timmer, P.; Trovato, A.; Tsagkli, S.; Tzamariudaki, E.; Tzanetatos, D.; Valieri, C.; Vallage, B.; Van Elewyck, V.; Versari, F.; Viola, S.; Vivolo, D.; Volkert, M.; de Waardt, L.; Wilms, J.; de Wolf, E.; Zaborov, D.; Zornoza, J.D.; Zúñiga, J.

2018-01-01

The Hamamatsu R12199-02 3-inch photomultiplier tube is the photodetector chosen for the first phase of the KM3NeT neutrino telescope. About 7000 photomultipliers have been characterised for dark count rate, timing spread and spurious pulses. The quantum efficiency, the gain and the peak-to-valley

Phase I Upgrade of the CMS Hadron Calorimeter

CERN Document Server

Cooper, Seth Isaac

2014-01-01

In preparation for Run 2 (2015) and Run 3 of the LHC (2019), the CMS hadron calorimeter has begun a series of ambitious upgrades. These include new photodetectors in addition to improved front-end and back-end readout electronics. In the hadron forward calorimeter, the existing photomultiplier tubes are being replaced with thinner window, multi-anode readout models, while in the central region, the hybrid photodiodes will be replaced with silicon photomultipliers. The front-end electronics will include high precision timing readout, and the backend electronics will handle the increased data bandwidth. The barrel and endcap longitudinal segmentation will also be increased. This report will describe the motivation for the upgrade, its major components, and its current status.

Temperature influence on spectroscopic properties and 2.7-μm lasing of Er:YAP crystal

Science.gov (United States)

Švejkar, Richard; Šulc, Jan; Němec, Michal; Jelínková, Helena; Nejezchleb, Karel; Čech, Miroslav

2018-02-01

The spectroscopic and laser properties of Er:YAP crystal, that is appropriate for generation at 2.7 μm, in temperature range 78 - 400 K are presented. The sample of Er:YAP (1 at. % of Er3+) had face-polished plan-parallel faces without anti-reflection coatings (thickness 4.47 mm). During experiments the Er:YAP was attached to temperature controlled copper holder and it was placed in vacuum chamber. The transmission and emission spectra together with the fluorescence decay time were measured depending on temperature. The Er:YAP crystal was longitudinally pumped by radiation from laser diode that works in pulse regime (repetition rate 66.6 Hz, pulse duration 1.5 ms, pump wavelength 972.5 nm) or in CW regime. Laser resonator was hemispherical, 145 mm in length with flat pumping mirror (HR @ 2.7 μm) and spherical output coupler (r = 150 mm, R = 95 % @ 2.5 - 2.8 μm). The fluorescence decay time of manifold 4I11/2 (upper laser level) became shorter and intensity of up-conversion radiation was increasing with decreasing temperature. In pulsed regime, the highest slope efficiency with respect to absorbed mean power was 1.27 % at 78 K. The maximum output of mean power was 3.5 mW at 78 K, i.e. 8.7 times higher than measured this value at 300 K. The maximal output power 27 mW with slope efficiency up to 3.5 % was achieved in CW. The radiation generated by Er:YAP laser (2.73 μm) is close to absorption peak of water (3 μm) thus this wavelength can be use in medicine and spectroscopy.

The PhE4-49B photomultiplier spply providing the protection from the geomagnetic field

International Nuclear Information System (INIS)

Georgiev, V.V.; Gladyshev, V.A.

1980-01-01

To protect a scintillation detector from the effect of the geomagnetic field it is proposed to use an experimentally selected voltage divider in the FEhU-49B photomultiplier supplying circuit. Employment of such a divider makes it possible to increase the electrostatic field strength in the photomultiplier input chamber which ensures better collection of photoelectrons on the first dynode, to decrease effect of the magnetic field on electron focusing and to increase the first dynode secondary emission coefficient. Selection of photomultiplier supplying conditions is carried out experimentally on a scintillation counter with a plastic scintillator. The potentials of the focusing electrode and the first dynode are adjusted so that the relation between the counting rate at a photomultiplier orientation along the magnetic field lines of force and the counting rate at normal orientation to the lines of force is minimum. Usage of the experimentally selected voltage divider improves the scintillation counter time resolution and decreases the photomultiplier operating supply voltage by 100-150 V. The scintillation counter provided with a proposed divider requires no magnetic shields [ru

Gamma induced atom displacements in LYSO and LuYAP crystals as used in medical imaging applications

Energy Technology Data Exchange (ETDEWEB)

Piñera, Ibrahin, E-mail: ipinera@ceaden.edu.cu [Centro de Aplicaciones Tecnológicas y Desarrollo Nuclear, CEADEN, 30 St. 502, Playa 11300, Havana (Cuba); Cruz, Carlos M.; Abreu, Yamiel; Leyva, Antonio [Centro de Aplicaciones Tecnológicas y Desarrollo Nuclear, CEADEN, 30 St. 502, Playa 11300, Havana (Cuba); Van Espen, Piet [University of Antwerp, CGB, Groenenborgerlaan 171, 2020 Antwerpen (Belgium); Díaz, Angelina; Cabal, Ana E. [Centro de Aplicaciones Tecnológicas y Desarrollo Nuclear, CEADEN, 30 St. 502, Playa 11300, Havana (Cuba); Van Remortel, Nick [University of Antwerp, CGB, Groenenborgerlaan 171, 2020 Antwerpen (Belgium)

2015-08-01

The radiation damage, in terms of atom displacements, induced by gamma irradiation in LYSO and LuYAP crystals is presented. {sup 44}Sc, {sup 22}Na and {sup 48}V are used as gamma sources for this study. The energy of gammas from the electron–positron annihilation processes (511 keV) is also included in the study. The atom displacements distributions inside each material are calculated following the Monte Carlo assisted Classical Method introduced by the authors. This procedure also allows to study the atom displacements in-depth distributions inside each crystal. The atom displacements damage in LYSO crystals is found to be higher than in LuYAP crystals, mainly provoked by the displacements of silicon and oxygen atoms. But the difference between atom displacements produced in LYSO and LuYAP decreases when more energetic sources are used. On the other hand, the correlation between the atom displacements and energy deposition in-depth distributions is excellent. The atom displacements to energy deposition ratio is found to increases with more energetic photon sources. LYSO crystals are then more liable to the atom displacements damage than LuYAP crystals.

Segmented scintillation detectors with silicon photomultiplier readout for measuring antiproton annihilations

CERN Document Server

Sótér, A.; Kobayashi, T.; Barna, D.; Horváth, D.; Hori, M.

2014-01-01

The Atomic Spectroscopy and Collisions Using Slow Antiprotons (ASACUSA) experiment at the Antiproton Decelerator (AD) facility of CERN constructed segmented scintillators to detect and track the charged pions which emerge from antiproton annihilations in a future superconducting radiofrequency Paul trap for antiprotons. A system of 541 cast and extruded scintillator bars were arranged in 11 detector modules which provided a spatial resolution of 17 mm. Green wavelength-shifting fibers were embedded in the scintillators, and read out by silicon photomultipliers which had a sensitive area of 1 x 1 mm^2. The photoelectron yields of various scintillator configurations were measured using a negative pion beam of momentum p ~ 1 GeV/c. Various fibers and silicon photomultipliers, fiber end terminations, and couplings between the fibers and scintillators were compared. The detectors were also tested using the antiproton beam of the AD. Nonlinear effects due to the saturation of the silicon photomultiplier were seen a...

First characterization of the Hamamatsu R11265 multi-anode photomultiplier tube

International Nuclear Information System (INIS)

Calvi, M.; Cassina, L.; Giachero, A.; Gotti, C.; Maino, M.; Matteuzzi, C.; Pessina, G.

2014-01-01

The characterization of the new Hamamatsu R11265-103-M64 multi-anode photomultiplier tube is presented. The sample available in our laboratory was tested and in particular the response to single photon was extensively studied. The gain, the anode uniformity and the dark current were measured. The tube behaviour in a longitudinal magnetic field up to 100 G was studied and the gain loss due to the ageing was quantified. The characteristics and performance of the photomultiplier tube make the R11265-103-M64 particularly tailored for an application in high energy physics experiments, such as in the LHCb Ring Imaging Cherenkov (RICH) detector at LHC. - Highlights: • We tested the new Hamamatsu R11265-103-M64 multi-anode photomultiplier tube. • We studied the response to single photon, the gain and the anode uniformity. • The tube behaviour in a longitudinal magnetic field up to 100 G was studied. • The gain loss due to the aging was quantified

Hippo-independent activation of YAP by the GNAQ uveal melanoma oncogene through a trio-regulated rho GTPase signaling circuitry.

Science.gov (United States)

Feng, Xiaodong; Degese, Maria Sol; Iglesias-Bartolome, Ramiro; Vaque, Jose P; Molinolo, Alfredo A; Rodrigues, Murilo; Zaidi, M Raza; Ksander, Bruce R; Merlino, Glenn; Sodhi, Akrit; Chen, Qianming; Gutkind, J Silvio

2014-06-16

Mutually exclusive activating mutations in the GNAQ and GNA11 oncogenes, encoding heterotrimeric Gαq family members, have been identified in ∼ 83% and ∼ 6% of uveal and skin melanomas, respectively. However, the molecular events underlying these GNAQ-driven malignancies are not yet defined, thus limiting the ability to develop cancer-targeted therapies. Here, we focused on the transcriptional coactivator YAP, a critical component of the Hippo signaling pathway that controls organ size. We found that Gαq stimulates YAP through a Trio-Rho/Rac signaling circuitry promoting actin polymerization, independently of phospholipase Cβ and the canonical Hippo pathway. Furthermore, we show that Gαq promotes the YAP-dependent growth of uveal melanoma cells, thereby identifying YAP as a suitable therapeutic target in uveal melanoma, a GNAQ/GNA11-initiated human malignancy. Copyright © 2014 Elsevier Inc. All rights reserved.

A method to stabilise the performance of negatively fed KM3NeT photomultipliers

Science.gov (United States)

Adrián-Martínez, S.; Ageron, M.; Aiello, S.; Albert, A.; Ameli, F.; Anassontzis, E. G.; Andre, M.; Androulakis, G.; Anghinolfi, M.; Anton, G.; Ardid, M.; Avgitas, T.; Barbarino, G.; Barbarito, E.; Baret, B.; Barrios-Martí, J.; Belias, A.; Berbee, E.; van den Berg, A.; Bertin, V.; Beurthey, S.; van Beveren, V.; Beverini, N.; Biagi, S.; Biagioni, A.; Billault, M.; Bondì, M.; Bormuth, R.; Bouhadef, B.; Bourlis, G.; Bourret, S.; Boutonnet, C.; Bouwhuis, M.; Bozza, C.; Bruijn, R.; Brunner, J.; Buis, E.; Buompane, R.; Busto, J.; Cacopardo, G.; Caillat, L.; Calamai, M.; Calvo, D.; Capone, A.; Caramete, L.; Cecchini, S.; Celli, S.; Champion, C.; Cherubini, S.; Chiarella, V.; Chiarelli, L.; Chiarusi, T.; Circella, M.; Classen, L.; Cobas, D.; Cocimano, R.; Coelho, J. A. B.; Coleiro, A.; Colonges, S.; Coniglione, R.; Cordelli, M.; Cosquer, A.; Coyle, P.; Creusot, A.; Cuttone, G.; D'Amato, C.; D'Amico, A.; D'Onofrio, A.; De Bonis, G.; De Sio, C.; Di Capua, F.; Di Palma, I.; Distefano, C.; Donzaud, C.; Dornic, D.; Dorosti-Hasankiadeh, Q.; Drakopoulou, E.; Drouhin, D.; Durocher, M.; Eberl, T.; Eichie, S.; van Eijk, D.; El Bojaddaini, I.; Elsaesser, D.; Enzenhöfer, A.; Favaro, M.; Fermani, P.; Ferrara, G.; Frascadore, G.; Furini, M.; Fusco, L. A.; Gal, T.; Galatà, S.; Garufi, F.; Gay, P.; Gebyehu, M.; Giacomini, F.; Gialanella, L.; Giordano, V.; Gizani, N.; Gracia, R.; Graf, K.; Grégoire, T.; Grella, G.; Grmek, A.; Guerzoni, M.; Habel, R.; Hallmann, S.; van Haren, H.; Harissopulos, S.; Heid, T.; Heijboer, A.; Heine, E.; Henry, S.; Hernández-Rey, J. J.; Hevinga, M.; Hofestädt, J.; Hugon, C. M. F.; Illuminati, G.; James, C. W.; Jansweijer, P.; Jongen, M.; de Jong, M.; Kadler, M.; Kalekin, O.; Kappes, A.; Katz, U. F.; Keller, P.; Kieft, G.; Kießling, D.; Koffeman, E. N.; Kooijman, P.; Kouchner, A.; Kreter, M.; Kulikovskiy, V.; Lahmann, R.; Lamare, P.; Leisos, A.; Leonora, E.; Clark, M. Lindsey; Liolios, A.; Llorens Alvarez, C. D.; Lo Presti, D.; Löhner, H.; Lonardo, A.; Lotze, M.; Loucatos, S.; Maccioni, E.; Mannheim, K.; Manzali, M.; Margiotta, A.; Margotti, A.; Marinelli, A.; Mariš, O.; Markou, C.; Martínez-Mora, J. A.; Martini, A.; Marzaioli, F.; Mele, R.; Melis, K. W.; Michael, T.; Migliozzi, P.; Migneco, E.; Mijakowski, P.; Miraglia, A.; Mollo, C. M.; Mongelli, M.; Morganti, M.; Moussa, A.; Musico, P.; Musumeci, M.; Nicolau, C. A.; Olcina, I.; Olivetto, C.; Orlando, A.; Orzelli, A.; Pancaldi, G.; Paolucci, A.; Papaikonomou, A.; Papaleo, R.; Păvălaš, G. E.; Peek, H.; Pellegrini, G.; Pellegrino, C.; Perrina, C.; Pfutzner, M.; Piattelli, P.; Pikounis, K.; Poma, G. E.; Popa, V.; Pradier, T.; Pratolongo, F.; Pühlhofer, G.; Pulvirenti, S.; Quinn, L.; Racca, C.; Raffaelli, F.; Randazzo, N.; Real, D.; Resvanis, L.; Reubelt, J.; Riccobene, G.; Rossi, C.; Rovelli, A.; Saldaña, M.; Salvadori, I.; Samtleben, D. F. E.; Sánchez García, A.; Sánchez Losa, A.; Sanguineti, M.; Santangelo, A.; Santonocito, D.; Sapienza, P.; Schimmel, F.; Schmelling, J.; Schnabel, J.; Sciacca, V.; Sedita, M.; Seitz, T.; Sgura, I.; Simeone, F.; Sipala, V.; Spisso, B.; Spurio, M.; Stavropoulos, G.; Steijger, J.; Stellacci, S. M.; Stransky, D.; Taiuti, M.; Tayalati, Y.; Terrasi, F.; Tézier, D.; Theraube, S.; Timmer, P.; Töonnis, C.; Trasatti, L.; Travaglini, R.; Trovato, A.; Tsirigotis, A.; Tzamarias, S.; Tzamariudaki, E.; Vallage, B.; Van Elewyck, V.; Vermeulen, J.; Versari, F.; Vicini, P.; Viola, S.; Vivolo, D.; Volkert, M.; Wiggers, L.; Wilms, J.; de Wolf, E.; Zachariadou, K.; Zani, S.; Zornoza, J. D.; Zúñiga, J.

2016-12-01

The KM3NeT research infrastructure, currently under construction in the Mediterranean Sea, will host neutrino telescopes for the identification of neutrino sources in the Universe and for studies of the neutrino mass hierarchy. These telescopes will house hundreds of thousands of photomultiplier tubes that will have to be operated in a stable and reliable fashion. In this context, the stability of the dark counts has been investigated for photomultiplier tubes with negative high voltage on the photocathode and held in insulating support structures made of 3D printed nylon material. Small gaps between the rigid support structure and the photomultiplier tubes in the presence of electric fields can lead to discharges that produce dark count rates that are highly variable. A solution was found by applying the same insulating varnish as used for the high voltage bases directly to the outside of the photomultiplier tubes. This transparent conformal coating provides a convenient and inexpensive method of insulation.

The recent development and study of silicon photomultiplier

International Nuclear Information System (INIS)

Saveliev, Valeri

2004-01-01

Recent developments and results from the study of a Silicon Solid State Photomultiplier (Si-PM) are presented. The basis of this new type of photodetector is a fine structure of microcells operating in the Geiger mode with an internal gain greater than 106. Common signal output allows for the detector to be operated in the proportional mode, and to reach a dynamic range of 1.5x103. Such photodetectors have shown single photon response at room temperature with a fast timing of ∼100ps. They are compact, robust and non-sensitive to magnetic fields. Results show the detection of low-intensity light in single photon mode and the detection of minimal ionizing particles using a scintillation tile for hadron calorimetry. The silicon photomultiplier is suitable for wide application in scintillation calorimetry, medical application, etc

Scintillation response of BaF2 and YAlO3:Ce (YAP:Ce) to energetic ions

International Nuclear Information System (INIS)

Slunga, E.; Cederwall, B.; Ideguchi, E.; Kerek, A.; Klamra, W.; Marel, J. van der; Novak, D.; Norlin, L.-O.

2001-01-01

The scintillation response of BaF 2 and YAP:Ce to protons, α particles, 16 O and 28 Si ions in the 5-30 MeV range has been investigated. The ratio between the fast and slow parts of the scintillator signal for BaF 2 has been used to separate protons, α particles and heavier ions, and the dependence of this ratio on the particle energy has been studied. The time constants and intensities of the two components of the YAP:Ce signal were measured, as were the time constant and intensity of the weak component of the slow part of the BaF 2 signal. Furthermore, the dependence of the light yield on the particle energy has been investigated for both BaF 2 and YAP:Ce

Progress in ultrafast CsI-photocathode gaseous imaging photomultipliers

International Nuclear Information System (INIS)

Dagendorf, V.; Breskin, A.; Chechick, R.; Schmidt-Boecking, H.

1991-04-01

A large area low-pressure gas-filled UV-imaging photomultiplier with CsI photocathode is presented. The double step electron photomultiplier with a 10 torr CH 4 gas-filling enables stable high gain operation. The detection efficiency of photon in the wavelength range λ ∼ 170 nm (Xe scintilation light) is about 10% for 200 to 2000 nm thick photocathodes. We investigate the influence of various substrate materials, the thickness of the CsI-layer, the gas pressure and the gas composition on the performance of the photocathode. Furthermore we studied the stability of the photocathode under different operating conditions and its sensitivity to air. Measurements of the timing characteristic of the device yielded an ultimate time resolution of 350 ps (fwhm). (author)

WW domains of the yes-kinase-associated-protein (YAP transcriptional regulator behave as independent units with different binding preferences for PPxY motif-containing ligands.

Directory of Open Access Journals (Sweden)

Manuel Iglesias-Bexiga

Full Text Available YAP is a WW domain-containing effector of the Hippo tumor suppressor pathway, and the object of heightened interest as a potent oncogene and stemness factor. YAP has two major isoforms that differ in the number of WW domains they harbor. Elucidating the degree of co-operation between these WW domains is important for a full understanding of the molecular function of YAP. We present here a detailed biophysical study of the structural stability and binding properties of the two YAP WW domains aimed at investigating the relationship between both domains in terms of structural stability and partner recognition. We have carried out a calorimetric study of the structural stability of the two YAP WW domains, both isolated and in a tandem configuration, and their interaction with a set of functionally relevant ligands derived from PTCH1 and LATS kinases. We find that the two YAP WW domains behave as independent units with different binding preferences, suggesting that the presence of the second WW domain might contribute to modulate target recognition between the two YAP isoforms. Analysis of structural models and phage-display studies indicate that electrostatic interactions play a critical role in binding specificity. Together, these results are relevant to understand of YAP function and open the door to the design of highly specific ligands of interest to delineate the functional role of each WW domain in YAP signaling.

Study of the Light Emission Process from the Double Chooz Photomultipliers

Energy Technology Data Exchange (ETDEWEB)

Calvo, E.; Cerrada, M.; Crespo, J. I.; Gil-Botella, I.; Jimenez, S.; Lopez, M.; Novella, P.; Palomares, C.; Santorelli, R.; Verdugo, A.

2012-09-13

In this document we present a study of the light emitted by the base of a Hamamatsu R7081MOD-ASSY photomultiplier (PMT) of the same type used in the Double Chooz experiment. Several characteristic features of the light signal have been found in terms of amplitude, length and pulse shape. Additional investigations on the properties of the epoxy used to cover the photomultiplier base have been carried out. A possible explanation of the light emission process is discussed at the end of the study. (Author) 1 ref.

Photomultiplier pulse Read Out system for the preshower detector of the LHCb experiment

International Nuclear Information System (INIS)

Ajaltouni, Z.; Bohner, G.; Cornat, R.; Deschamps, O.; Lecoq, J.; Monteil, S.; Perret, P.

2003-01-01

The second generation experiment for CP violation studies in B decays, LHCb, is a 20-m-long single-arm spectrometer to be installed on the future Large Hadron Collider at CERN. For its precision measurement purpose, it combines precise vertex location and particle identification, in addition to a performance trigger system able to cope with high flux. The first level of trigger is mainly based on the fast response of the calorimetric subsystem. Of major importance is the 6000 channels preshower detector that aims to validate the electromagnetic nature of calorimetric showers. It consists of two-radiation-length lead sheet in front of a scintillator plane. Scintillator signals are extracted from plastic cells using wavelength-shifting fibres coupled to multi-anode photomultiplier tubes. The preshower Read Out system has to cope with fluctuating photomultiplier pulses caused by small amounts of photoelectrons, in addition to strong constraints imposed by the 40 MHz LHC bunch-crossing frequency. A special Read Out electronics including perfect 40 MHz integrators able to shape fluctuating photomultiplier pulses has been designed, and successfully realized. The temporal shape of photomultiplier pulse and the upstream Read Out system for preshower are described in this document

β-Catenin destruction complex-independent regulation of Hippo–YAP signaling by APC in intestinal tumorigenesis

Science.gov (United States)

Cai, Jing; Maitra, Anirban; Anders, Robert A.; Taketo, Makoto M.; Pan, Duojia

2015-01-01

Mutations in Adenomatous polyposis coli (APC) underlie familial adenomatous polyposis (FAP), an inherited cancer syndrome characterized by the widespread development of colorectal polyps. APC is best known as a scaffold protein in the β-catenin destruction complex, whose activity is antagonized by canonical Wnt signaling. Whether other effector pathways mediate APC's tumor suppressor function is less clear. Here we report that activation of YAP, the downstream effector of the Hippo signaling pathway, is a general hallmark of tubular adenomas from FAP patients. We show that APC functions as a scaffold protein that facilitates the Hippo kinase cascade by interacting with Sav1 and Lats1. Consistent with the molecular link between APC and the Hippo signaling pathway, genetic analysis reveals that YAP is absolutely required for the development of APC-deficient adenomas. These findings establish Hippo–YAP signaling as a critical effector pathway downstream from APC, independent from its involvement in the β-catenin destruction complex. PMID:26193883

A superconducting supercollider calorimeter photomultiplier tube preamplifier circuit

Energy Technology Data Exchange (ETDEWEB)

Panescu, D; Lackey, J; Robl, P; Smith, W H [Wisconsin Univ., Madison, WI (United States). Physics Dept.

1992-07-15

This study presents the design of the front end amplifier for a scintillator calorimeter with photomultiplier tube (PMT) readout. The design is based on analytical computations and SPICE simulations, and is checked against tests performed on a prototyped circuit. We were looking to achieve (1) a very low droop within the 4 ns after the integration of the photomultiplier tube (PMT) signal was completed, (2) a very low noise figure for the whole amplifier in a 100 MHz bandwidth, (3) an input impedance optimized for the PMT which is actually used, (4) baseline restoration as quick as possible at the output of the clip amps, (5) no loss of information due to the saturation at intermediary stages (e.g. integrator), and (6) an output driving 100 {Omega} twisted pair cables, or 50 {Omega} coaxial cables, in order to transmit the signal to switched capacitor arrays for analog storage. (orig.).

Understanding Windows | Efficient Windows Collaborative

Science.gov (United States)

Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

3,3'-[(E-eten-1,2-diil]di(9-heksil-9H-karbazol bileşiğinin sentezi, X-ışını yapı tayini ve teorik yapı tahmini

Directory of Open Access Journals (Sweden)

Erol Asker

2016-08-01

Full Text Available 3,3'-[(E-eten-1,2-diil]di(9-heksil-9H-karbazol bileşiği 9H-karbazoldan çıkarak üç basamakta sentezlenmiş ve yapısı spektroskopik yöntemlerle aydınlatılmıştır. Kristal yapısı monoklinik uzay grubu P21/c'de çözülmüş ve geometrik özellikleri yarı-deneysel PM7 ve teorik DFT/B3LYP hesaplamalarla elde edilen verilerle karşılaştırılmıştır. DFT hesapsal sonuçlar ile X-ışını kırınımı deneysel sonuçlar arasında yüksek korelasyon belirlenmiştir. Kristal yapıdaki moleküller arası etkileşimler hesaplanan öncü orbitallerle açıklanmaya çalışılmıştır.

Influence of Homogenization and Micro/Nano Source of Starting Powders on Format Ion of the Single YAP Phase

Directory of Open Access Journals (Sweden)

Michalik D.

2016-12-01

Full Text Available Manufacturing high purity polycrystalline YAlO3 (YAP ceramics could replace monocrystalline YAP thus recently it is an interesting task for low cost producers of scintillators. The paper presents influence of different source of initial oxide powders (micro/nano powders of Y2O3 and Al2O3 and the method of their homogenization on the formation of a YAP phase. The solid state reaction method was used to prepare YAP powder or ceramic pellets. After preheating, all samples in the form of powders and pellets were heat-treated in the temperature range of 1050-1650 °C. DTA method was applied for examination of the phase crystallization in the tested system. X-ray diffraction method (XRD was used for characterization of the phase composition. X-ray microanalysis (EDS was used to control homogeneity in the small areas. Morphology of the resultant samples are presented on SEM pictures. The results show a significant influence of the starting powders on the homogeneity, purity and temperature of formation of the main phase.

Impact of an AlAs window layer upon the optical properties of Al x Ga1-x As photodiodes

Science.gov (United States)

Kang, T.; Chen, X. J.; Johnson, E. B.; Christian, J. F.; Lee, K.; Hammig, M. D.

2016-05-01

Recently developed advanced scintillators, which have the ability to distinguish gamma-ray interaction events from those that accompany neutron impact, require improved quantum efficiency in the blue to near UV region of the spectrum. We utilize GaAs/Al0.8Ga0.2As photodiode elements as components in a wide band-gap solid-state photomultiplier as a lower-cost, lower logistical burden, and higher quantum efficiency replacement for the photomultiplier tube. An AlAs window layer is employed as a means to increase the diode’s optical performance. Relative to structures absent the window layer, simulations and measurements demonstrate that the AlAs layer produces a spatial coincidence between regions of large drift fields with regions of high photon absorption. In addition to the AlAs layer, secondary ion mass spectrometry measurements show that an unexpected high degree of inter-diffusion of GaAs and AlAs quenches the photon-detection efficiency, a decrease that can be avoided by its post-growth removal. With the AlAs layer, the peak external quantum efficiency of 49% is achieved at 450 nm with 10 V reverse bias, which does not fully deplete the device. Simulations show that full depletion can result in efficiencies exceeding 90%. In order to enhance the optical response, a simple anti-reflective coating layer is designed using the existing passivation layer components that successfully minimizes the reflection at the wavelength range of interest (300 nm-500 nm).

Impact of an AlAs window layer upon the optical properties of AlxGa1−xAs photodiodes

International Nuclear Information System (INIS)

Kang, T; Hammig, M D; Chen, X J; Johnson, E B; Christian, J F; Lee, K

2016-01-01

Recently developed advanced scintillators, which have the ability to distinguish gamma-ray interaction events from those that accompany neutron impact, require improved quantum efficiency in the blue to near UV region of the spectrum. We utilize GaAs/Al 0.8 Ga 0.2 As photodiode elements as components in a wide band-gap solid-state photomultiplier as a lower-cost, lower logistical burden, and higher quantum efficiency replacement for the photomultiplier tube. An AlAs window layer is employed as a means to increase the diode’s optical performance. Relative to structures absent the window layer, simulations and measurements demonstrate that the AlAs layer produces a spatial coincidence between regions of large drift fields with regions of high photon absorption. In addition to the AlAs layer, secondary ion mass spectrometry measurements show that an unexpected high degree of inter-diffusion of GaAs and AlAs quenches the photon-detection efficiency, a decrease that can be avoided by its post-growth removal. With the AlAs layer, the peak external quantum efficiency of 49% is achieved at 450 nm with 10 V reverse bias, which does not fully deplete the device. Simulations show that full depletion can result in efficiencies exceeding 90%. In order to enhance the optical response, a simple anti-reflective coating layer is designed using the existing passivation layer components that successfully minimizes the reflection at the wavelength range of interest (300 nm–500 nm). (paper)

Diode-pumped Tm:YAP/YVO4 intracavity Raman laser

International Nuclear Information System (INIS)

Zhao, Jiaqun; Zhou, Xiaofeng; Wang, Guodong; Cheng, Ping; Xu, Feng

2017-01-01

The laser performance based on YVO 4 Raman conversion in a diode-pumped actively Q-switched Tm:YAP laser is demonstrated for the first time. With an incident diode power of 10.9 W and a pulse repetition rate of 1 kHz, the average output powers for the first Stokes laser at 2.4 μm is about 270 mW. (paper)

Prenatal exposure to dietary fat induces changes in the transcriptional factors, TEF and YAP, which may stimulate differentiation of peptide neurons in rat hypothalamus.

Directory of Open Access Journals (Sweden)

Kinning Poon

Full Text Available Gestational exposure to a high-fat diet (HFD stimulates the differentiation of orexigenic peptide-expressing neurons in the hypothalamus of offspring. To examine possible mechanisms that mediate this phenomenon, this study investigated the transcriptional factor, transcription enhancer factor-1 (TEF, and co-activator, Yes-associated protein (YAP, which when inactivated stimulate neuronal differentiation. In rat embryos and postnatal offspring prenatally exposed to a HFD compared to chow, changes in hypothalamic TEF and YAP and their relationship to the orexigenic peptide, enkephalin (ENK, were measured. The HFD offspring at postnatal day 15 (P15 exhibited in the hypothalamic paraventricular nucleus a significant reduction in YAP mRNA and protein, and increased levels of inactive and total TEF protein, with no change in mRNA. Similarly, HFD-exposed embryos at embryonic day 19 (E19 showed in whole hypothalamus significantly decreased levels of YAP mRNA and protein and TEF mRNA, and increased levels of inactive TEF protein, suggesting that HFD inactivates TEF and YAP. This was accompanied by increased density and fluorescence intensity of ENK neurons. A close relationship between TEF and ENK was suggested by the finding that TEF co-localizes with this peptide in hypothalamic neurons and HFD reduced the density of TEF/ENK co-labeled neurons, even while the number and fluorescence intensity of single-labeled TEF neurons were increased. Increased YAP inactivity by HFD was further evidenced by a decrease in number and fluorescence intensity of YAP-containing neurons, although the density of YAP/ENK co-labeled neurons was unaltered. Genetic knockdown of TEF or YAP stimulated ENK expression in hypothalamic neurons, supporting a close relationship between these transcription factors and neuropeptide. These findings suggest that prenatal HFD exposure inactivates both hypothalamic TEF and YAP, by either decreasing their levels or increasing their inactive

Recent measurements on the Hamamatsu 13 in., R8055, PhotoMultiplier Tubes

International Nuclear Information System (INIS)

Tsagli, S.; Aggouras, G.; Anassontzis, E.G.; Ball, A.E.; Chinowsky, W.; Fahrun, E.; Grammatikakis, G.; Green, C.; Grieder, P.; Katrivanos, P.; Koske, P.; Ludvig, J.; Markopoulos, E.; Minkowsky, P.; Nygren, D.; Papageorgiou, K.; Przybylski, G.; Resvanis, L.K.; Siotis, I.; Sopher, J.; Staveris, T.; Tsagli, V.; Zhukov, V.A.

2006-01-01

The key component of NESTOR, the deep-sea Cherenkov neutrino telescope, built in the Mediterranean, NW of Greece, is the optical module. The NESTOR Optical Module employs a PhotoMultiplier Tube (PMT) in a transparent glass pressure housing. The Hamamatsu PMT R8055-01, 13 in. photomultiplier was selected for NESTOR to replace the old 15'' Hamamatsu PMTs (R2018-03). Extensive tests have been made on the sensitivity, uniformity, time resolution and noise rates of 162 R8055-01 13 in. PMTs

Scintillation hodoscope with working area of 50 x 50 cm based on hodoscopic photomultipliers

International Nuclear Information System (INIS)

Borog, V.V.; Vasil'chenko, V.G.; Demekhin, A.V.; Dronov, V.V.; Rykalin, V.I.

1987-01-01

The choice of optimum designs for the sensitive elements of large hodoscopes based on hodoscopic photomultipliers is examined. The results of numerical calculations are confirmed by measurement results. The measured space resolution of one of the scintillation-hodoscope designs (with two hodoscopic photomultipliers) with a sensitive volume of 50 x 50 x 2 mm is ≤ +3 mm

Stabilisation of photo-multiplying gain; Stabilisation du gain des pbotomultiplicateurs

Energy Technology Data Exchange (ETDEWEB)

Tretiakoff, O; Bailly du Bois, B [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1956-07-01

The use of photomultiplier tubes in experimental physics is thwarted by their high responsiveness to changes in the feeding tension. Their use can be extended a great deal by a simple efficient stabilizing device which allows them to work in the same way as Geiger-Mueller tubes without losing the advantageous characteristics of photomultiplier tubes. (author) [French] L'utilisation des tubes photomultiplicateurs en physique experimentale se heurte a l'obstacle que constitue leur extreme sensibilite aux variations de la tension d'alimentation. Un systeme de stabilisation simple et efficace, permettant d'apparenter leurs caracteristiques a celles des compteurs Geiger-Muller tout en conservant les avantages propres aux tubes photomultiplicateurs, peut elargir considerablement leur domaine d'emploi. (auteur)

System for high-voltage control detectors with large number photomultipliers

International Nuclear Information System (INIS)

Donskov, S.V.; Kachanov, V.A.; Mikhajlov, Yu.V.

1985-01-01

A simple and inexpensive on-line system for hihg-voltage control which is designed for detectors with a large number of photomultipliers is developed and manufactured. It has been developed for the GAMC type hodoscopic electromagnetic calorimeters, comprising up to 4 thousand photomultipliers. High voltage variation is performed by a high-speed potentiometer which is rotated by a microengine. Block-diagrams of computer control electronics are presented. The high-voltage control system has been used for five years in the IHEP and CERN accelerator experiments. The operation experience has shown that it is quite simple and convenient in operation. In case of about 6 thousand controlled channels in both experiments no potentiometer and microengines failures were observed

Characterization of the ETEL D784UKFLB 11 in. photomultiplier tube

Energy Technology Data Exchange (ETDEWEB)

Barros, N.; Kaptanoglu, T. [University of Pennsylvania, Philadelphia, PA 19104 (United States); Kimelman, B. [Muhlenberg College, Allentown, PA 18104 (United States); Klein, J.R. [University of Pennsylvania, Philadelphia, PA 19104 (United States); Moore, E.; Nguyen, J. [University of California, Davis, Davis, CA 95616 (United States); Stavreva, K. [University of Pennsylvania, Philadelphia, PA 19104 (United States); Svoboda, R., E-mail: rsvoboda@physics.ucdavis.edu [University of California, Davis, Davis, CA 95616 (United States)

2017-04-21

Water Cherenkov and scintillator detectors are a critical tool for neutrino physics. Their large size, low threshold, and low operational cost make them excellent detectors for long baseline neutrino oscillations, proton decay, supernova and solar neutrinos, double beta decay, and ultra-high energy astrophysical neutrinos. Proposals for a new generation of large detectors rely on the availability of large format, fast, cost-effective photomultiplier tubes. The Electron Tubes Enterprises, Ltd (ETEL) D784KFLB 11 in. Photomultiplier Tube has been developed for large neutrino detectors. We have measured the timing characteristics, relative efficiency, and magnetic field sensitivity of the first fifteen prototypes.

LIX1 regulates YAP1 activity and controls the proliferation and differentiation of stomach mesenchymal progenitors.

Science.gov (United States)

McKey, Jennifer; Martire, Delphine; de Santa Barbara, Pascal; Faure, Sandrine

2016-04-28

Smooth muscle cell (SMC) plasticity maintains the balance between differentiated SMCs and proliferative mesenchymal progenitors, crucial for muscular tissue homeostasis. Studies on the development of mesenchymal progenitors into SMCs have proven useful in identifying molecular mechanisms involved in digestive musculature plasticity in physiological and pathological conditions. Here, we show that Limb Expression 1 (LIX1) molecularly defines the population of mesenchymal progenitors in the developing stomach. Using in vivo functional approaches in the chick embryo, we demonstrate that LIX1 is a key regulator of stomach SMC development. We show that LIX1 is required for stomach SMC determination to regulate the expression of the pro-proliferative gene YAP1 and mesenchymal cell proliferation. However, as stomach development proceeds, sustained LIX1 expression has a negative impact on further SMC differentiation and this is associated with a decrease in YAP1 activity. We demonstrate that expression of LIX1 must be tightly regulated to allow fine-tuning of the transcript levels and state of activation of the pro-proliferative transcriptional coactivator YAP1 to regulate proliferation rates of stomach mesenchymal progenitors and their differentiation. Our data highlight dual roles for LIX1 and YAP1 and provide new insights into the regulation of cell density-dependent proliferation, which is essential for the development and homeostasis of organs.

Analysis of photon statistics with Silicon Photomultiplier

International Nuclear Information System (INIS)

D'Ascenzo, N.; Saveliev, V.; Wang, L.; Xie, Q.

2015-01-01

The Silicon Photomultiplier (SiPM) is a novel silicon-based photodetector, which represents the modern perspective of low photon flux detection. The aim of this paper is to provide an introduction on the statistical analysis methods needed to understand and estimate in quantitative way the correct features and description of the response of the SiPM to a coherent source of light

The role of the Yap5 transcription factor in remodeling gene expression in response to Fe bioavailability.

Directory of Open Access Journals (Sweden)

Catarina Pimentel

Full Text Available The budding yeast Saccharomyces cerevisiae has developed several mechanisms to avoid either the drastic consequences of iron deprivation or the toxic effects of iron excess. In this work, we analysed the global gene expression changes occurring in yeast cells undergoing iron overload. Several genes directly or indirectly involved in iron homeostasis showed altered expression and the relevance of these changes are discussed. Microarray analyses were also performed to identify new targets of the iron responsive factor Yap5. Besides the iron vacuolar transporter CCC1, Yap5 also controls the expression of glutaredoxin GRX4, previously known to be involved in the regulation of Aft1 nuclear localization. Consistently, we show that in the absence of Yap5 Aft1 nuclear exclusion is slightly impaired. These studies provide further evidence that cells control iron homeostasis by using multiple pathways.

Improved SPICE electrical model of silicon photomultipliers

Energy Technology Data Exchange (ETDEWEB)

Marano, D., E-mail: davide.marano@oact.inaf.it [INAF, Osservatorio Astrofisico di Catania, Via S. Sofia 78, I-95123 Catania (Italy); Bonanno, G.; Belluso, M.; Billotta, S.; Grillo, A.; Garozzo, S.; Romeo, G. [INAF, Osservatorio Astrofisico di Catania, Via S. Sofia 78, I-95123 Catania (Italy); Catalano, O.; La Rosa, G.; Sottile, G.; Impiombato, D.; Giarrusso, S. [INAF, Istituto di Astrofisica Spaziale e Fisica Cosmica di Palermo, Via U. La Malfa 153, I-90146 Palermo (Italy)

2013-10-21

The present work introduces an improved SPICE equivalent electrical model of silicon photomultiplier (SiPM) detectors, in order to simulate and predict their transient response to avalanche triggering events. In particular, the developed circuit model provides a careful investigation of the magnitude and timing of the read-out signals and can therefore be exploited to perform reliable circuit-level simulations. The adopted modeling approach is strictly related to the physics of each basic microcell constituting the SiPM device, and allows the avalanche timing as well as the photodiode current and voltage to be accurately simulated. Predictive capabilities of the proposed model are demonstrated by means of experimental measurements on a real SiPM detector. Simulated and measured pulses are found to be in good agreement with the expected results. -- Highlights: • An improved SPICE electrical model of silicon photomultipliers is proposed. • The developed model provides a truthful representation of the physics of the device. • An accurate charge collection as a function of the overvoltage is achieved. • The adopted electrical model allows reliable circuit-level simulations to be performed. • Predictive capabilities of the adopted model are experimentally demonstrated.

Window Glazing Types | Efficient Windows Collaborative

Science.gov (United States)

Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

Window Frame Types | Efficient Windows Collaborative

Science.gov (United States)

Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

Window Operator Types | Efficient Windows Collaborative

Science.gov (United States)

Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

A new trend in photomultiplier techniques and its implications in future collider experiments

International Nuclear Information System (INIS)

Kuroda, K.

1989-01-01

A recent trend in photomultiplier techniques, characterized by immunity to magnetic fields and position sensitivity of modern photomultiplier tubes, would potentially have great importance in future collider experiments. This article presents a survey on the actual status of the art, and some implications of such new techniques in future high-energy experiments. As an example of applications, our recent project of constructing an ultrafast scintillating-fibre detector on the basis of upgraded position-sensitive PMTs is outlined. (orig.)

Growth and scintillation properties of Pr doped YAP with different Pr concentrations

International Nuclear Information System (INIS)

Yanagida, Takayuki; Kamada, Kei; Fujimoto, Yutaka; Sugiyama, Makoto; Furuya, Yuki; Yamaji, Akihiro; Yokota, Yuui; Yoshikawa, Akira

2010-01-01

Pr 3+ 0.2, 0.75, and 3 mol% doped YAP single crystalline scintillators were grown by using the micro-pulling down (μ-PD) method. Pr 3+ 0.05 mol% doped YAP was also prepared by using the Czochralski method. In transmittance spectra, 4f-5d absorption line appeared at 230 nm. The μ-PD grown crystals showed intense emission at 290 nm while the Czochralski grown one showed an emission peak at 245 nm in radio luminescence spectra under X-ray excitation. Among them, the Czochralski grown one exhibited the highest light yield under 137 Cs 662 keV excitation and the absolute light yield of this sample was estimated to be 20400±2000 ph/MeV. The decay time constants of these scintillators were around 10 ns due to Pr 3+ 5d-4f transition.

Growth and scintillation properties of Pr doped YAP with different Pr concentrations

Energy Technology Data Exchange (ETDEWEB)

Yanagida, Takayuki, E-mail: t_yanagi@tagen.tohoku.ac.j [Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai 980-8577 (Japan); Kamada, Kei; Fujimoto, Yutaka; Sugiyama, Makoto; Furuya, Yuki [Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai 980-8577 (Japan); Yamaji, Akihiro [New Industry Creation Hatchery Center (NICHe), Tohoku University, 6-6-10 Aoba, Aramaki, Aoba-ku, Sendai 980-8579 (Japan); Yokota, Yuui [Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai 980-8577 (Japan); Yoshikawa, Akira [Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai 980-8577 (Japan); New Industry Creation Hatchery Center (NICHe), Tohoku University, 6-6-10 Aoba, Aramaki, Aoba-ku, Sendai 980-8579 (Japan)

2010-11-21

Pr{sup 3+} 0.2, 0.75, and 3 mol% doped YAP single crystalline scintillators were grown by using the micro-pulling down ({mu}-PD) method. Pr{sup 3+} 0.05 mol% doped YAP was also prepared by using the Czochralski method. In transmittance spectra, 4f-5d absorption line appeared at 230 nm. The {mu}-PD grown crystals showed intense emission at 290 nm while the Czochralski grown one showed an emission peak at 245 nm in radio luminescence spectra under X-ray excitation. Among them, the Czochralski grown one exhibited the highest light yield under {sup 137}Cs 662 keV excitation and the absolute light yield of this sample was estimated to be 20400{+-}2000 ph/MeV. The decay time constants of these scintillators were around 10 ns due to Pr{sup 3+} 5d-4f transition.

Hodoscope module with miniature photomultipliers

International Nuclear Information System (INIS)

Bel'zer, L.I.; Gribushin, A.M.; Zhil'tsov, L.Ya.; Matveeva, E.N.; Philipenko, T.D.; Sinev, N.B.

1987-01-01

The experimental Scintillation Magnetic Spectrometer (SMS) installation, whose main element is an extended hodoscope system, is being built for the accelerator of the High Energy Laboratory of the Joint Institute for Nuclear Research. The authors describe the scintillation hodoscope of the SMS installation and present the applicable amplitude and time characteristics of several types of miniature photomultipliers (FEU-58, FEU-60, FEU-114-1, FEU-147-1, and R-1635 (Hamamatsu, Japan)), which were obtained with a 106 Ru radioactive source and standard plastic scintillators of two types, based on oxazoles in polystyrene and in polymethylmethacrylate

Modeling crosstalk and afterpulsing in silicon photomultipliers

International Nuclear Information System (INIS)

Rosado, J.; Aranda, V.M.; Blanco, F.; Arqueros, F.

2015-01-01

An experimental method to characterize the crosstalk and afterpulsing in silicon photomultipliers has been developed and applied to two detectors fabricated by Hamamatsu. An analytical model of optical crosstalk that we presented in a previous publication has been compared with new measurements, confirming our results. Progresses on a statistical model to describe afterpulsing and delayed crosstalk are also shown and compared with preliminary experimental data

Modeling crosstalk and afterpulsing in silicon photomultipliers

Energy Technology Data Exchange (ETDEWEB)

Rosado, J., E-mail: jaime_ros@fis.ucm.es; Aranda, V.M.; Blanco, F.; Arqueros, F.

2015-07-01

An experimental method to characterize the crosstalk and afterpulsing in silicon photomultipliers has been developed and applied to two detectors fabricated by Hamamatsu. An analytical model of optical crosstalk that we presented in a previous publication has been compared with new measurements, confirming our results. Progresses on a statistical model to describe afterpulsing and delayed crosstalk are also shown and compared with preliminary experimental data.

Corrosion of Glass Windows in DIRC PMTs

Energy Technology Data Exchange (ETDEWEB)

Va' vra, Jaroslav

2001-07-27

The DIRC photon detector contains {approx}11,000 photomultipliers (PMTs), which are submerged in ultra-pure water. This note reports on glass corrosion R and D conducted with PMTs in pure water. We conclude that only limited number ({approx}50) of the PMTs in water are affected by rapid corrosion, while a majority of the 11,000 PMTs should last, according to our measurements, for another ten years. The observation of PMT glass corrosion is based on visual observations, X-ray surface analysis, ESCA surface analysis, weight analysis, transmission measurement, as well as detailed water trace element analysis. We also correlate these observations with DIRC measurements of water pH factor, resistivity, temperature, transmission, and BaBar analysis of Bhabha and di-muon events. We also compare DIRC water purity with that of the Super Kamiokande and K2K experiments, which also use ultra-pure water. We provide empirical proof that corrosion, in our particular Borosilicate type of PMT glass window, occurs at high rate when the glass has no Zn content.

Photomultipliers gain monitoring at the one percent level with a blue light pulser

International Nuclear Information System (INIS)

Berger, J.; Bermond, M.; Besson, P.; Favier, J.; Pessard, H.; Poulet, M.

1988-07-01

We describe a method and an experimental layout allowing the monitoring of photomultipliers gain. We use artificial blue light (Spark-gap with filter: 436 ± 20 nm) and three reference detectors. Short term and long term measurements are presented. The results indicate a precision better than 0.5% for the short term and 1.4% for the long term determinations. This gain monitoring system has been developed for a new neutrino oscillation reactor experiment (600 photomultipliers) starting at the Bugey nuclear plant

Development of gaseous photomultiplier

International Nuclear Information System (INIS)

Tokanai, F.; Sumiyoshi, T.; Sugiyama, H.; Okada, T.

2014-01-01

We have been developing gaseous photomultiplier tubes (PMTs) with alkali photocathode combined with micropattern gas detectors (MPGDs). The potential advantage of the gaseous PMT is that it can achieve a very large effective area with adequate position and timing resolutions. In addition, it will be easily operated under a very high magnetic field, compared with the conventional vacuum-based PMT. To evaluate the gaseous PMTs filled with Ne and Ar based gas mixture, we have developed gaseous PMTs with an alkali photocathode combined with MPGDs such as a glass capillary plate, GEM, and Micromegas detector. We describe the recent development of the gaseous PMTs, particularly the production of the photocathode, gas gain, ion and photon feedbacks, quantum efficiency, and the characteristics in the magnetic field environment. (author)

LD end pumped mode locked and cavity dumped Nd:YAP laser at 1.34 μm

Science.gov (United States)

Wang, X.; Wang, S.; Rhee, H.; Eichler, H. J.; Meister, S.

2011-06-01

We report a LD end pumped actively mode locked, passively Q switched and cavity dumped Nd:YAP laser at 1.34 μm. The dumped output pulse energy of 160 μJ is obtained at a repetition rate of 10 Hz. Passing through a LD end pumped, double-passed Nd:YAP amplifier the pulse energy is amplified to 1.44 mJ. The corresponding amplification factor is 9. Stimulated Raman scattering experiment is taken with a 9 mm long PbWO4 Raman crystal. Maximum of 20% Raman conversion is reached.

The Neurofibromatosis 2 Tumor Suppressor Gene Product, Merlin, Regulates Human Meningioma Cell Growth by Signaling through YAP

Directory of Open Access Journals (Sweden)

Katherine Striedinger

2008-11-01

Full Text Available Neurofibromatosis type 2 (NF2 is an autosomal dominant disorder characterized by the occurrence of schwannomas and meningiomas. Several studies have examined the ability of the NF2 gene product, merlin, to function as a tumor suppressor in diverse cell types; however, little is known about merlin growth regulation in meningiomas. In Drosophila, merlin controls cell proliferation and apoptosis by signaling through the Hippo pathway to inhibit the function of the transcriptional coactivator Yorkie. The Hippo pathway is conserved in mammals. On the basis of these observations, we developed human meningioma cell lines matched for merlin expression to evaluate merlin growth regulation and investigate the relationship between NF2 status and Yes-associated protein (YAP, the mammalian homolog of Yorkie. NF2 loss in meningioma cells was associated with loss of contact-dependent growth inhibition, enhanced anchorage-independent growth and increased cell proliferation due to increased S-phase entry. In addition, merlin loss in both meningioma cell lines and primary tumors resulted in increased YAP expression and nuclear localization. Finally, siRNA-mediated reduction of YAP in NF2-deficient meningioma cells rescued the effects of merlin loss on cell proliferation and S-phase entry. Collectively, these results represent the first demonstration that merlin regulates cell growth in human cancer cells by suppressing YAP.

Targeting Signaling to YAP for the Therapy of NF2

Science.gov (United States)

2016-12-01

nucleus, thus activating YAP-driven transcription and oncogenesis. Genetic epistasis experiments provided evidence that this oncogenic pathway...which loss of Merlin activates mitogenic signaling by using somatic cell genetics and biochemistry. In addition, we have initiated high-throughput...which represents the ultimate long term goal of this grant. Although our studies have identified a critical role for nuclear Merlin in inhibition of

Characterization of 1600 Hamamatsu 16-anode photomultipliers for the MINOS Far detector

International Nuclear Information System (INIS)

Lang, K.; Day, J.; Eilerts, S.; Fuqua, S.; Guillen, A.; Kordosky, M.; Lang, M.; Liu, J.; Opaska, W.; Proga, M.; Vahle, P.; Winbow, A.; Drake, G.; Thomas, J.; Andreopoulos, C.; Saoulidou, N.; Stamoulis, P.; Tzanakos, G.; Zois, M.; Weber, A.; Michael, D.

2005-01-01

We are reporting results of the characterization of over 1600 multi-anode R5900-00-M16 photomultipliers manufactured by Hamamatsu Photonics K.K., and installed in the MINOS Far detector. We have conducted extensive tests of the uniformity of gain and collection efficiency of individual anodes, the cross-talk among all 16 channels, the dark noise, and the linearity of response. In our studies we used a blue light-emitting diode to illuminate phototubes through 1.2 mm diameter optical fibers. In this paper, we present summaries of the main characteristics of the tested photomultipliers

Fbxw7 Deletion Accelerates KrasG12D-Driven Pancreatic Tumorigenesis via Yap Accumulation.

Science.gov (United States)

Zhang, Qiang; Zhang, Yaqing; Parsels, Joshua D; Lohse, Ines; Lawrence, Theodore S; Pasca di Magliano, Marina; Sun, Yi; Morgan, Meredith A

2016-11-01

Pancreatic cancers driven by KRAS mutations require additional mutations for tumor progression. The tumor suppressor FBXW7 is altered in pancreatic cancers, but its contribution to pancreatic tumorigenesis is unknown. To determine potential cooperation between Kras mutation and Fbxw7 inactivation in pancreatic tumorigenesis, we generated P48-Cre;LSL-Kras G12D ;Fbxw7 fl/fl (KFC fl/fl ) compound mice. We found that KFC fl/fl mice displayed accelerated tumorigenesis: all mice succumbed to pancreatic ductal adenocarcinoma (PDA) by 40 days of age, with PDA onset occurring by 2 weeks of age. PDA in KFC fl/fl mice was preceded by earlier onset of acinar-to-ductal metaplasia (ADM) and pancreatic intraepithelial neoplasia (PanIN) lesions, and associated with chromosomal instability and the accumulation of Fbxw7 substrates Yes-associated protein (Yap), c-Myc, and Notch. Using KFC fl/fl and FBXW7-deficient human pancreatic cancer cells, we found that Yap silencing attenuated growth promotion by Fbxw7 deletion. Our data demonstrate that Fbxw7 is a potent suppressor of Kras G12D -induced pancreatic tumorigenesis due, at least in part, to negative regulation of Yap. Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.

A full Monte Carlo simulation of the YAP-PEM prototype for breast tumor detection

Science.gov (United States)

Motta, A.; Righi, S.; Del Guerra, A.; Belcari, N.; Vaiano, A.; De Domenico, G.; Zavattini, G.; Campanini, R.; Lanconelli, N.; Riccardi, A.

2004-07-01

A prototype for Positron Emission Mammography, the YAP-PEM, is under development within a collaboration of the Italian Universities of Pisa, Ferrara, and Bologna. The aim is to detect breast lesions, with dimensions of 5 mm in diameter, and with a specific activity ratio of 10:1 between the cancer and breast tissue. The YAP-PEM is composed of two stationary detection heads of 6×6 cm 2, composed of a matrix of 30×30 YAP:Ce finger crystals of 2×2×30 mm 3 each. The EGSnrc Monte Carlo code has been used to simulate several characteristics of the prototype. A fast EM algorithm has been adapted to reconstruct all of the collected lines of flight, also at large incidence angles, by achieving 3D positioning capability of the lesion in the FOV. The role of the breast compression has been studied. The performed study shows that a 5 mm diameter tumor of 37 kBq/cm 3 (1 μCi/cm 3), embedded in active breast tissue with 10:1 tumor/background specific activity ratio, is detected in 10 min with a Signal-to-Noise Ratio of 8.7±1.0. Two hot lesions in the active breast phantom are clearly visible in the reconstructed image.

Influence of incident light wavelength on time jitter of fast photomultipliers

International Nuclear Information System (INIS)

Moszynski, M.; Vacher, J.

1977-01-01

The study of the single photoelectron time resolution as a function of the wavelength of the incident light was performed for a 56 CVP photomultiplier having an S-1 photocathode. The light flash from the XP22 light emitting diode generator was passed through passband filters and illuminated the 5 mm diameter central part of the photocathode. A significant increase of the time resolution above 30% was observed when the wavelength of the incident light was changed from 790 nm to 580 nm. This gives experimental evidence that the time jitter resulting from the spread of the initial velocity of photoelectrons is proportional to the square root of the maximal initial energy of photoelectrons. Based on this conclusion the measured time jitter of C31024, RCA8850 and XP2020 photomultipliers with the use of the XP22 light emitting diode at 560 nm light wavelength was recalculated to estimate the time jitter at 400 nm near the maximum of the photocathode sensitivity. It shows an almost twice larger time spread at 400 nm for the C31024 and RCA8850 with a high gain first dynode and an about 1.5 times larger time spread for the XP2020 photomultiplier, than those measured at 560 nm. (Auth.)

Studies of scintillation light nonproportionality of ZnSe(Te), CsI(Tl) and YAP(Ce) crystals using heavy ions

CERN Document Server

Klamra, W; Kapusta, M; Kérek, A; Moszynski, M; Norlin, L O; Novák, D; Possnert, G

2002-01-01

The scintillation light yield for ZnSe(Te), CsI(Tl) and YAP(Ce) crystals have been studied with alpha particles, sup 1 sup 2 C and sup 8 sup 1 Br in the energy region 2.8-42.2 MeV. A nonproportional behavior was observed, mostly pronounced for alpha particles on YAP(Ce). The results are understood in terms of delta-rays effect.

Towards Optical Partial Discharge Detection with Micro Silicon Photomultipliers

Directory of Open Access Journals (Sweden)

Ming Ren

2017-11-01

Full Text Available Optical detection is reliable in intrinsically characterizing partial discharges (PDs. Because of the great volume and high-level power supply of the optical devices that can satisfy the requirements in photosensitivity, optical PD detection can merely be used in laboratory studies. To promote the practical application of the optical approach in an actual power apparatus, a silicon photomultiplier (SiPM-based PD sensor is introduced in this paper, and its basic properties, which include the sensitivity, pulse resolution, correlation with PD severity, and electromagnetic (EM interference immunity, are experimentally evaluated. The stochastic phase-resolved PD pattern (PRPD for three typical insulation defects are obtained by SiPM PD detector and are compared with those obtained using a high-frequency current transformer (HFCT and a vacuum photomultiplier tube (PMT. Because of its good performances in the above aspects and its additional advantages, such as the small size, low power supply, and low cost, SiPM offers great potential in practical optical PD monitoring.

Performance studies of varian VPM-154D.6D VPM-154A/1.6L static crossed field photomultipliers

International Nuclear Information System (INIS)

Lo, C.C.; Leskovar, B.

1977-01-01

Characteristics have been measured for the Varian VPM-154D.6D and VPM-154A/1.6L Static Crossed Field Photomultipliers. Some typical photomultiplier characteristics such as: gain, dark current, quantum efficiency, and rise-time--are compared with data provided by the manufacturer. Photomultiplier characteristics generally not available from the manufacturer, such as: transit time, FWHM of the output pulse, peak output current measurement and multiphotoelectron time resolution were measured and are discussed

Proper Installation of Replacement Windows | Efficient Windows

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Test of digital neutron–gamma discrimination with four different photomultiplier tubes for the NEutron Detector Array (NEDA)

Energy Technology Data Exchange (ETDEWEB)

Luo, X.L., E-mail: luo.xiaoliang@physics.uu.se [Department of Instrument Science and Technology, College of Mechatronics and Automation, National University of Defense Technology, Changsha (China); Department of Physics and Astronomy, Uppsala University, SE-75120 Uppsala (Sweden); Modamio, V. [INFN, Laboratori Nazionali di Legnaro, I-35020 Legnaro, Padova (Italy); Nyberg, J. [Department of Physics and Astronomy, Uppsala University, SE-75120 Uppsala (Sweden); Valiente-Dobón, J.J. [INFN, Laboratori Nazionali di Legnaro, I-35020 Legnaro, Padova (Italy); Nishada, Q. [Department of Physics and Astronomy, Uppsala University, SE-75120 Uppsala (Sweden); Angelis, G. de [INFN, Laboratori Nazionali di Legnaro, I-35020 Legnaro, Padova (Italy); Agramunt, J. [IFIC-CSIC, University of Valencia, Valencia (Spain); Egea, F.J. [IFIC-CSIC, University of Valencia, Valencia (Spain); Faculty of Engineering and Natural Sciences, Istanbul Sabahattin Zaim University, Istanbul (Turkey); Erduran, M.N.; Ertürk, S. [Nigde Universitesi, Fen-Edebiyat Falkültesi, Fizik Bölümü, Nigde (Turkey); France, G. de [GANIL, CEA/DSAM and CNRS/IN2P3, Bd Henri Becquerel, BP 55027, F-14076 Caen Cedex 05 (France); Gadea, A. [IFIC-CSIC, University of Valencia, Valencia (Spain); González, V. [Department of Electronic Engineering, University of Valencia, E-46071 Valencia (Spain); Hüyük, T. [IFIC-CSIC, University of Valencia, Valencia (Spain); Jaworski, G. [Faculty of Physics, Warsaw University of Technology, ul. Koszykowa 75, 00-662 Warszawa (Poland); Heavy Ion Laboratory, University of Warsaw, ul. Pasteura 5A, 02-093 Warszawa (Poland); Moszyński, M. [Heavy Ion Laboratory, University of Warsaw, ul. Pasteura 5A, 02-093 Warszawa (Poland); National Centre for Nuclear Research, A. Soltana 7, PL 05-400 Otwock-Swierk (Poland); and others

2014-12-11

A comparative study of the neutron–γ discrimination performance of a liquid scintillator detector BC501A coupled to four different 5 in. photomultiplier tubes (ET9390kb, R11833-100, XP4512 and R4144) was carried out. Both the Charge Comparison method and the Integrated Rise-Time method were implemented digitally to discriminate between neutrons and γ rays emitted by a {sup 252}Cf source. In both methods, the neutron–γ discrimination capabilities of the four photomultiplier tubes were quantitatively compared by evaluating their figure-of-merit values at different energy regions between 50 keVee and 1000 keVee. Additionally, the results were further verified qualitatively using time-of-flight to distinguish γ rays and neutrons. The results consistently show that photomultiplier tubes R11833-100 and ET9390kb generally perform best regarding neutron–γ discrimination with only slight differences in figure-of-merit values. This superiority can be explained by their relatively higher photoelectron yield, which indicates that a scintillator detector coupled to a photomultiplier tube with higher photoelectron yield tends to result in better neutron–γ discrimination performance. The results of this work will provide reference for the choice of photomultiplier tubes for future neutron detector arrays like NEDA.

Performance Standards for Windows | Efficient Windows Collaborative

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Assessing Window Replacement Options | Efficient Windows Collaborative

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WIP-YAP/TAZ as A New Pro-Oncogenic Pathway in Glioma

Directory of Open Access Journals (Sweden)

Sergio Rivas

2018-06-01

Full Text Available Wild-type p53 (wtp53 is described as a tumour suppressor gene, and mutations in p53 occur in many human cancers. Indeed, in high-grade malignant glioma, numerous molecular genetics studies have established central roles of RTK-PI3K-PTEN and ARF-MDM2-p53 INK4a-RB pathways in promoting oncogenic capacity. Deregulation of these signalling pathways, among others, drives changes in the glial/stem cell state and environment that permit autonomous growth. The initially transformed cell may undergo subsequent modifications, acquiring a more complete tumour-initiating phenotype responsible for disease advancement to stages that are more aggressive. We recently established that the oncogenic activity of mutant p53 (mtp53 is driven by the actin cytoskeleton-associated protein WIP (WASP-interacting protein, correlated with tumour growth, and more importantly that both proteins are responsible for the tumour-initiating cell phenotype. We reported that WIP knockdown in mtp53-expressing glioblastoma greatly reduced proliferation and growth capacity of cancer stem cell (CSC-like cells and decreased CSC-like markers, such as hyaluronic acid receptor (CD44, prominin-1 (CD133, yes-associated protein (YAP and transcriptional co-activator with PDZ-binding motif (TAZ. We thus propose a new CSC signalling pathway downstream of mtp53 in which Akt regulates WIP and controls YAP/TAZ stability. WIP drives a mechanism that stimulates growth signals, promoting YAP/TAZ and β-catenin stability in a Hippo-independent fashion, which allows cells to coordinate processes such as proliferation, stemness and invasiveness, which are key factors in cancer progression. Based on this multistep tumourigenic model, it is tantalizing to propose that WIP inhibitors may be applied as an effective anti-cancer therapy.

Elevated YAP and its downstream targets CCN1 and CCN2 in basal cell carcinoma: impact on keratinocyte proliferation and stromal cell activation.

Science.gov (United States)

Quan, Taihao; Xu, Yiru; Qin, Zhaoping; Robichaud, Patrick; Betcher, Stephanie; Calderone, Ken; He, Tianyuan; Johnson, Timothy M; Voorhees, John J; Fisher, Gary J

2014-04-01

Yes-associated protein (YAP) is a transcriptional co-activator of hippo signaling pathway, which plays an important role in organ size control and tumorigenesis. Here we report that YAP and its downstream transcriptional targets CCN1 and CCN2 are markedly elevated in keratinocytes in human skin basal cell carcinoma tumor islands. In human keratinocytes, knockdown of YAP significantly reduced expression of CCN1 and CCN2, and repressed proliferation and survival. This inhibition of proliferation and survival was rescued by restoration of CCN1 expression, but not by CCN2 expression. In basal cell carcinoma stroma, CCN2-regulated genes type I collagen, fibronectin, and α-smooth muscle actin were highly expressed. Furthermore, atomic force microscopy revealed increased tissue stiffness in basal cell carcinoma stroma compared to normal dermis. These data provide evidence that up-regulation of YAP in basal cell carcinoma impacts both aberrant keratinocyte proliferation, via CCN1, and tumor stroma cell activation and stroma remodeling, via CCN2. Targeting YAP and/or CCN1 and CCN2 may provide clinical benefit in basal cell carcinoma. Copyright © 2014 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.

Analysis of single-photon time resolution of FBK silicon photomultipliers

International Nuclear Information System (INIS)

Acerbi, Fabio; Ferri, Alessandro; Gola, Alberto; Zorzi, Nicola; Piemonte, Claudio

2015-01-01

We characterized and analyzed an important feature of silicon photomultipliers: the single-photon time resolution (SPTR). We characterized the SPTR of new RGB (Red–Green–Blue) type Silicon Photomultipliers and SPADs produced at FBK (Trento, Italy), studying its main limiting factors. We compared time resolution of 1×1 mm 2 and 3×3 mm 2 SiPMs and a single SiPM cell (i.e. a SPAD with integrated passive-quenching), employing a mode-locked pulsed laser with 2-ps wide pulses. We estimated the contribution of front-end electronic-noise, of cell-to-cell uniformity, and intrinsic cell time-resolution. At a single-cell level, we compared the results obtained with different layouts. With a circular cell with a top metallization covering part of the edge and enhancing the signal extraction, we reached ~20 ps FWHM of time resolution

Test of multi-anode photomultiplier tubes for the LHCb scintillator pad detector

CERN Document Server

Aguiló, Ernest; Comerma-Montells, A; Garrido, Lluis; Gascon, David; Graciani, Ricardo; Grauges, Eugeni; Vilasis Cardona, Xavier; Xirgu, Xavier; Bohner, Gerard; Bonnefoy, Romeo; Borras, David; Cornat, Remi; Crouau, Michel; Deschamps, Olivier; Jacquet, Philippe; Lecoq, Jacques; Monteil, Stephane; Perret, Pascal; Reinmuth, Guy

2005-01-01

The LHCb experiment (The LHCb Technical Proposal, CERN/LHCC 98-4) is designed to study B meson physics in the LHC proton-proton collider at CERN. The Scintillator Pad Detector (SPD) has been designed to complete the calorimeter information performing an e/gamma identification for the experiment level-0 trigger system. The detection technology consists in transmitting scintillation light by means of both Wavelength Shifting and clear fibers to fast multi- anode photomultiplier tubes. In this paper, it is described the instrumentation and setup used to characterize the baseline photomultiplier solution (Hamamatsu R5900-00-M64) together with the scintillators and optical fibers for the SPD at LHCb.

Peynir Yapımında Mikrobiyal Renet Kullanımı

Directory of Open Access Journals (Sweden)

Mehmet Karapınar

2015-02-01

Full Text Available Peynir yapımında süt koagulantı olarak buzağı reneti yerine kullanılmak üzere proteazlar üzerine yapılan çalışmalar son yıllarda yoğunluk kazanmıştır. Günümüzde buzağı reneti standart bir süt koagulantı olarak önemini sürdürmekteyse de, şirden mayası üretimi her yıl giderek gereksinimi karşılayamaz duruma gelmektedir. Bunun sonucu olarak yeni renet kaynakları arasında yoğunlaşmış ve günümüzde Mucor pusillus, M. miehei, Endothia parasitica küf türlerinden elde edilen üç fungal enzim ile Bacillus cereus bakterisinden elde edilen bir bakteriyel enzim ticari olarak üretilmeye başlanmıştır.

Design of a 5 GHz window in a lower hybrid r.f. system

International Nuclear Information System (INIS)

Maebara, S.; Ikeda, Y.; Seki, M.; Imai, T.

1995-01-01

A new pill-box window at a frequency of 5GHz, which has an oversized length in both the axial and the radial direction, has been designed to reduce the r.f. power density and the electric field strength at the ceramics. The dimension of the new pill-box is optimized from the numerical calculation and a voltage standing-wave ratio of less than 1.02 is obtained. The r.f. power density and the maximum electric field strength are reduced to about 40% and 66% of the standard pill-box window respectively. It is evaluated that the power capability of the new oversized pill-box window by cooling edge of ceramics is more than 500kW with continuous-wave operation. ((orig.))

A Hybrid Chaos-Particle Swarm Optimization Algorithm for the Vehicle Routing Problem with Time Window

Directory of Open Access Journals (Sweden)

Qi Hu

2013-04-01

Full Text Available State-of-the-art heuristic algorithms to solve the vehicle routing problem with time windows (VRPTW usually present slow speeds during the early iterations and easily fall into local optimal solutions. Focusing on solving the above problems, this paper analyzes the particle encoding and decoding strategy of the particle swarm optimization algorithm, the construction of the vehicle route and the judgment of the local optimal solution. Based on these, a hybrid chaos-particle swarm optimization algorithm (HPSO is proposed to solve VRPTW. The chaos algorithm is employed to re-initialize the particle swarm. An efficient insertion heuristic algorithm is also proposed to build the valid vehicle route in the particle decoding process. A particle swarm premature convergence judgment mechanism is formulated and combined with the chaos algorithm and Gaussian mutation into HPSO when the particle swarm falls into the local convergence. Extensive experiments are carried out to test the parameter settings in the insertion heuristic algorithm and to evaluate that they are corresponding to the data’s real-distribution in the concrete problem. It is also revealed that the HPSO achieves a better performance than the other state-of-the-art algorithms on solving VRPTW.

Characterization of large-area photomultipliers under low magnetic fields: Design and performance of the magnetic shielding for the Double Chooz neutrino experiment

International Nuclear Information System (INIS)

Calvo, E.; Cerrada, M.; Fernandez-Bedoya, C.; Gil-Botella, I.; Palomares, C.; Rodriguez, I.; Toral, F.; Verdugo, A.

2010-01-01

A precise quantitative measurement of the effect of low magnetic fields in Hamamatsu R7081 photomultipliers has been performed. These large-area photomultipliers will be used in the Double Chooz neutrino experiment. A magnetic shielding has been developed for these photomultipliers. Its design and performance is also reported in this paper.

Stability and lifetime testing of photomultiplier detectors for the Earth observing system SOLSTICE program

Science.gov (United States)

Hadler, Joshua A.; van de Kop, Toni; Drake, Virginia A.; McClintock, William E.; Murphy, John; Rodgers, Paul

1998-10-01

The primary objective of the Earth Observing System (EOS) Solar Stellar Irradiance Comparison Experiment (SOLSTICE) is to accurately measure the absolute value of the solar UV irradiance at the top of the earth's atmosphere for a minimum mission lifetime of 5 years. To meet this objective, SOLSTICE employs a unique design to determine changes in instrument performance by routinely observing a series of early-type stars and comparing the irradiances directly with the solar value. Although the comparison techniques allows us to track instrument performance, the success of the SOLSTICE experiment depends upon photomultiplier detectors which have graceful degradation properties. Therefore, we have established a laboratory program to evaluate the characteristics of photomultiplier tubes which are exposed to long term fluxes similar to those we expected to encounter in flight. Three types of Hamamatsu photomultiplier tubes were tested as candidates for use in the EOS-SOLSTICE project. The results of these studies: pulse height distribution; quantum efficiency; surface maps,; and lifetime analysis are presented in this paper.

Hybrid Windows and Mosaic Video: Reducing Complexity of Space Habitable Modules

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National Aeronautics and Space Administration — We want to look at the concept of combining small, passive windows with replaceable cameras to improve viewing capabilities for habitable modules of future...

Performance evaluation of neuro-PET using silicon photomultipliers

Energy Technology Data Exchange (ETDEWEB)

Jung, Jiwoong; Choi, Yong, E-mail: ychoi@sogang.ac.kr; Jung, Jin Ho, E-mail: jinho1115@gmail.com; Kim, Sangsu; Im, Ki Chun

2016-05-21

Recently, we have developed the second prototype Silicon photomultiplier (SiPM) based positron emission tomography (PET) scanner for human brain imaging. The PET system was comprised of detector block which consisted of 4×4 SiPMs and 4×4 Lutetium Yttrium Orthosilicate arrays, charge signal transmission method, high density position decoder circuit and FPGA-embedded ADC boards. The purpose of this study was to evaluate the performance of the newly developed neuro-PET system. The energy resolution, timing resolution, spatial resolution, sensitivity, stability of the photo-peak position and count rate performance were measured. Tomographic image of 3D Hoffman brain phantom was also acquired to evaluate imaging capability of the neuro-PET. The average energy and timing resolutions measured for 511 keV gamma rays were 17±0.1% and 3±0.3 ns, respectively. Spatial resolution and sensitivity at the center of field of view (FOV) were 3.1 mm and 0.8%, respectively. The average scatter fraction was 0.4 with an energy window of 350–650 keV. The maximum true count rate and maximum NECR were measured as 43.3 kcps and 6.5 kcps at an activity concentration of 16.7 kBq/ml and 5.5 kBq/ml, respectively. Long-term stability results show that there was no significant change in the photo-peak position, energy resolution and count rate for 60 days. Phantom imaging studies were performed and they demonstrated the feasibility for high quality brain imaging. The performance tests and imaging results indicate that the newly developed PET is useful for brain imaging studies, if the axial FOV is extended to improve the system sensitivity.

Dynamic range broadening for photomultipliers in kinetic spectrophotometry

International Nuclear Information System (INIS)

Rumas, V.K.

1983-01-01

The circuit of switching on a photomultiplier with prestage modulation developed for kinetic spectrophotometry purposes is described. Distinguishing features of the scheme are wide range of control pulse duration (40 nc - 2.5 mc) and direct transistor photostart by laser light pulse. In the case of PM prestage modulation for the second dynode modulation depth attains 400 while PM opening time constitutes 40 nc

A simple method to improve the spatial uniformity of venetian-blind photomultiplier tubes

International Nuclear Information System (INIS)

Santos, J.M.F. dos; Veloso, J.F.C.A.; Morgado, R.E.

1996-01-01

An improvement in the uniformity of venetian-blind photomultiplier tubes has been achieved by reducing the voltage difference between the first and second dynodes. The method has been applied to a gas proportional scintillation counter (GPSC) instrumented with a venetian-blind photomultiplier (PMT). When exposed to a 20-mm collimated 5.9-keV x-ray beam, an overall improvement in energy resolution for the GPSC/PMT combination from 20% to 11.5% was achieved. An alternative method that reduces the photocathode-to-first-dynode voltage was less effective and resulted in a severe degradation of detector energy resolution

Analysis of single-photon time resolution of FBK silicon photomultipliers

Energy Technology Data Exchange (ETDEWEB)

Acerbi, Fabio, E-mail: acerbi@fbk.eu; Ferri, Alessandro; Gola, Alberto; Zorzi, Nicola; Piemonte, Claudio

2015-07-01

We characterized and analyzed an important feature of silicon photomultipliers: the single-photon time resolution (SPTR). We characterized the SPTR of new RGB (Red–Green–Blue) type Silicon Photomultipliers and SPADs produced at FBK (Trento, Italy), studying its main limiting factors. We compared time resolution of 1×1 mm{sup 2} and 3×3 mm{sup 2} SiPMs and a single SiPM cell (i.e. a SPAD with integrated passive-quenching), employing a mode-locked pulsed laser with 2-ps wide pulses. We estimated the contribution of front-end electronic-noise, of cell-to-cell uniformity, and intrinsic cell time-resolution. At a single-cell level, we compared the results obtained with different layouts. With a circular cell with a top metallization covering part of the edge and enhancing the signal extraction, we reached ~20 ps FWHM of time resolution.

Preliminary assessment of the imaging capability of the YAP-(S)PET small animal scanner in neuroscience

International Nuclear Information System (INIS)

Bartoli, Antonietta; Belcari, Nicola; Stark, Daniela; Hoehnemann, Sabine; Piel, Markus; Jennewein, Marc; Schmitt, Ulrich; Tillmanns, Julia; Thews, Oliver; Hiemke, Christoph; Roesch, Frank; Del Guerra, Alberto

2006-01-01

The new and fully engineered version of the YAP-(S)PET small animal scanner has been tested at the University of Mainz for preliminary assessment of its imaging capability for studies related to neuropharmacology and psychiatry. The main feature of the scanner is the capability to combine PET and SPECT techniques. It allows the development of new and interesting protocols for the investigation of many biological phenomena, more effectively than with PET or SPECT modalities alone. The scanner is made up of four detector heads, each one composed of a 4x4 cm 2 of YAlO 3 :Ce (or YAP:Ce) matrix, and has a field of view (FOV) of 4 cm axiallyx4 cm o transaxially. In PET mode, the volume resolution is less than 8 mm 3 and is nearly constant over the whole FOV, while the sensitivity is about 2%. The SPECT performance is not so good, due to the presence of the multi-hole lead collimator in front of each head. Nevertheless, the YAP-PET scanner offers excellent resolution and sensitivity for performing on the availability of D2-like dopamine receptors on mice and rats in both PET and SPECT modalities

LHCb : Behaviour of Multi-anode Photomultipliers in Magnetic Fields for the LHCb RICH Upgrde

CERN Multimedia

Gambetta, Silvia

2015-01-01

A key feature of the LHCb upgrade, scheduled for 2019, is to remove the first level trigger and its data reduction from 40MHz to 1MHz, which is implemented in the on-detector readout electronics. The consequence for the LHCb Ring Imaging Cherenkov (RICH) detectors is that the Hybrid Photon Detectors need to be replaced as the readout chip is inside the detector vacuum. The baseline for replacement are Multianode Photomultiplier tubes (MaPMT) and new readout electronics. The MaPMTs will be located in the fringe field of the LHCb dipole magnet with residual fields up to 25 G. Therefore, their behaviour in magnetic fields is critical. Here we report about studies of the Hamamatsu models R11265 and H12700 in a magnetic field in an effort to qualify them for use in the LHCb RICH upgrade. Comparisons to the known model R7600 are also made. Measurements of the collection efficiency and gain were performed for all three space directions as a function of the magnetic field strength. In addition to measurements with ba...

Replacement Windows for Existing Homes Homes | Efficient Windows

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Design Guidance for New Windows | Efficient Windows Collaborative

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Selection Process for New Windows | Efficient Windows Collaborative

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Selection Process for Replacement Windows | Efficient Windows Collaborative

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Design Guidance for Replacement Windows | Efficient Windows Collaborative

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Proper Installation of New Windows | Efficient Windows Collaborative

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Development of gamma spectrometer using silicon photomultiplier (SiPM)

International Nuclear Information System (INIS)

Kim, Chan Kyu

2011-02-01

Gamma spectroscopy is used to determine the identity and quantity of gamma-emitters in nuclear physics, geochemistry and astrophysics. The scintillation detectors are being used as a gamma spectrometer generally, because of their higher gamma-ray detection efficiency and cheaper price than germanium semi-conductor detectors. A typical scintillation detector is composed of a scintillator, a window, and a photodetector. The photomultiplier (PM) tube has been the most widely used as a photodetector because of its advantages like high sensitivity, high signal-to-noise ratio, and wide dynamic range. Recently, the Silicon Photomultiplier (SiPM) is being studied as a substitute of PM tube. The SiPM has almost same performance compared to PM tube but it has additional advantages; low operating voltage, small volume, and cheap production cost. In this research, the gamma spectrometer using SiPM instead of PM tube is developed. The use of SiPM as a photodetector makes the gamma spectrometer smaller, cheaper, easier to use. For photon transport and collection from the large area scintillator to the small area SiPM, a light guide is applied in this gamma spectrometer system. Before fabrication of light guide, DETECT simulation is performed to study and prospect characteristics of light guide structure. And actual light guides are fabricated on the basis of this simulation result. Poly(methyl methacrylate) (PMMA) is chosen as material of light guide, 5 sample light guides are fabricated in different lengths and coatings. As a scintillator crystal, same NaI(Tl) crystal is chosen. For measurement and analysis of gamma spectrometer system, 3 gamma spectrometer systems are composed: PM tube-based system, PM tube-based system with the light guide, SiPM-based system with the light guide. Through comparison between the results of each gamma spectrometer, the performances of gamma spectrometer system are analyzed by each component. Measurement results of the second system is well

Iterated local search algorithm for solving the orienteering problem with soft time windows.

Science.gov (United States)

Aghezzaf, Brahim; Fahim, Hassan El

2016-01-01

In this paper we study the orienteering problem with time windows (OPTW) and the impact of relaxing the time windows on the profit collected by the vehicle. The way of relaxing time windows adopted in the orienteering problem with soft time windows (OPSTW) that we study in this research is a late service relaxation that allows linearly penalized late services to customers. We solve this problem heuristically by considering a hybrid iterated local search. The results of the computational study show that the proposed approach is able to achieve promising solutions on the OPTW test instances available in the literature, one new best solution is found. On the newly generated test instances of the OPSTW, the results show that the profit collected by the OPSTW is better than the profit collected by the OPTW.

YAP/TAZ-Dependent Reprogramming of Colonic Epithelium Links ECM Remodeling to Tissue Regeneration

DEFF Research Database (Denmark)

Yui, Shiro; Azzolin, Luca; Maimets, Martti

2018-01-01

by remodeling the extracellular matrix (ECM), increased FAK/Src signaling, and ultimately YAP/TAZ activation. In a defined cell culture system recapitulating the extracellular matrix remodeling observed in vivo, we show that a collagen 3D matrix supplemented with Wnt ligands is sufficient to sustain endogenous...

Prostaglandin E2 Activates YAP and a Positive-Signaling Loop to Promote Colon Regeneration After Colitis but Also Carcinogenesis in Mice.

Science.gov (United States)

Kim, Han-Byul; Kim, Minchul; Park, Young-Soo; Park, Intae; Kim, Tackhoon; Yang, Sung-Yeun; Cho, Charles J; Hwang, DaeHee; Jung, Jin-Hak; Markowitz, Sanford D; Hwang, Sung Wook; Yang, Suk-Kyun; Lim, Dae-Sik; Myung, Seung-Jae

2017-02-01

Prostaglandin E 2 (PGE 2 ) is mediator of inflammation that regulates tissue regeneration, but its continual activation has been associated with carcinogenesis. Little is known about factors in the PGE 2 signaling pathway that contribute to tumor formation. We investigated whether yes-associated protein 1 (YAP1), a transcriptional co-activator in the Hippo signaling pathway, mediates PGE 2 function. DLD-1 and SW480 colon cancer cell lines were transfected with vectors expressing transgenes or small hairpin RNAs and incubated with recombinant PGE 2 , with or without pharmacologic inhibitors of signaling proteins, and analyzed by immunoblot, immunofluorescence, quantitative reverse-transcription polymerase chain reaction, transcriptional reporter, and proliferation assays. Dextran sodium sulfate (DSS) was given to induce colitis in C57/BL6 (control) mice, as well as in mice with disruption of the hydroxyprostaglandin dehydrogenase 15 gene (15-PGDH-knockout mice), Yap1 gene (YAP-knockout mice), and double-knockout mice. Some mice also were given indomethacin to block PGE 2 synthesis. 15-PGDH knockout mice were crossed with mice with intestine-specific disruption of the salvador family WW domain containing 1 gene (Sav1), which encodes an activator of Hippo signaling. We performed immunohistochemical analyses of colon biopsy samples from 26 patients with colitis-associated cancer and 51 age-and sex-matched patients with colorectal cancer (without colitis). Incubation of colon cancer cell lines with PGE 2 led to phosphorylation of cyclic adenosine monophosphate-responsive element binding protein 1 and increased levels of YAP1 messenger RNA, protein, and YAP1 transcriptional activity. This led to increased transcription of the prostaglandin-endoperoxide synthase 2 gene (PTGS2 or cyclooxygenase 2) and prostaglandin E-receptor 4 gene (PTGER4 or EP4). Incubation with PGE 2 promoted proliferation of colon cancer cell lines, but not cells with knockdown of YAP1. Control mice

Preliminary assessment of the imaging capability of the YAP-(S)PET small animal scanner in neuroscience

Energy Technology Data Exchange (ETDEWEB)

Bartoli, Antonietta [Department of Physics ' E. Fermi' and Center of Excellence ' AmbiSEN' , University of Pisa, and INFN, Sezione di Pisa, Pisa I- 56127 (Italy)]. E-mail: bartoli@df.unipi.it; Belcari, Nicola [Department of Physics ' E. Fermi' and Center of Excellence ' AmbiSEN' , University of Pisa, and INFN, Sezione di Pisa, Pisa I- 56127 (Italy); Stark, Daniela [Institute of Nuclear Chemistry, University of Mainz, Mainz D-55099 (Germany); Hoehnemann, Sabine [Institute of Nuclear Chemistry, University of Mainz, Mainz D-55099 (Germany); Piel, Markus [Institute of Nuclear Chemistry, University of Mainz, Mainz D-55099 (Germany); Jennewein, Marc [Institute of Nuclear Chemistry, University of Mainz, Mainz D-55099 (Germany); Schmitt, Ulrich [Department of Psychiatry, University of Mainz, Mainz D-55099 (Germany); Tillmanns, Julia [Institute of Physiology and Pathophysiology, University of Mainz, Mainz D-55099 (Germany); Thews, Oliver [Institute of Physiology and Pathophysiology, University of Mainz, Mainz D-55099 (Germany); Hiemke, Christoph [Department of Psychiatry, University of Mainz, Mainz D-55099 (Germany); Roesch, Frank [Institute of Nuclear Chemistry, University of Mainz, Mainz D-55099 (Germany); Del Guerra, Alberto [Department of Physics ' E. Fermi' and Center of Excellence ' AmbiSEN' , University of Pisa, and INFN, Sezione di Pisa, Pisa I- 56127 (Italy)

2006-12-20

The new and fully engineered version of the YAP-(S)PET small animal scanner has been tested at the University of Mainz for preliminary assessment of its imaging capability for studies related to neuropharmacology and psychiatry. The main feature of the scanner is the capability to combine PET and SPECT techniques. It allows the development of new and interesting protocols for the investigation of many biological phenomena, more effectively than with PET or SPECT modalities alone. The scanner is made up of four detector heads, each one composed of a 4x4 cm{sup 2} of YAlO{sub 3}:Ce (or YAP:Ce) matrix, and has a field of view (FOV) of 4 cm axiallyx4 cm o transaxially. In PET mode, the volume resolution is less than 8 mm{sup 3} and is nearly constant over the whole FOV, while the sensitivity is about 2%. The SPECT performance is not so good, due to the presence of the multi-hole lead collimator in front of each head. Nevertheless, the YAP-PET scanner offers excellent resolution and sensitivity for performing on the availability of D2-like dopamine receptors on mice and rats in both PET and SPECT modalities.

Windows

DEFF Research Database (Denmark)

Heiselberg, Per; Svidt, Kjeld; Nielsen, Peter V.

In natural ventilation systems fresh air is often provided through opening of windows. However, the knowledge of the performance of windows is rather limited. Computation of natural ventilation air flow through windows is most commonly made using discharge coefficients, that are regarded as being...... constant. The reported results show that the discharge coefficient for a window opening cannot be regarded as a constant and that it varies considerably with the size of the opening area, the window type and the temperature difference. Therefore, the use of a constant value can lead to serious errors...

Imaging properties of cerium doped Yttrium Aluminum Oxide (YAP:Ce) powder scintillating screens under X-ray excitation

Energy Technology Data Exchange (ETDEWEB)

Kalivas, N. [Greek Atomic Energy Commission, 15310 Ag. Paraskevi, P.O. Box 60092 (Greece); Valais, I. [Department of Medical Physics, Medical School, University of Patras, 26500 Patras (Greece)]|[Department of Medical Instruments Technology, Technological Educational Institution of Athens, Ag. Spyridonos Street, Aigaleo, 12210 Athens (Greece); Salemis, G.; Karagiannis, C.; Konstantinidis, A.; Nikolopoulos, D. [Department of Medical Instruments Technology, Technological Educational Institution of Athens, Ag. Spyridonos Street, Aigaleo, 12210 Athens (Greece); Loudos, G.; Sakelios, N.; Karakatsanis, N.; Nikita, K. [Department of Electrical and Computer Engineering, National Technical University of Athens, 9 Iroon Polytechniou, 15780 Zografos (Greece); Gayshan, V.L.; Gektin, A.V. [Institute of Scintillation Materials, Lenin Avenue 60, 310072 Kharkov (Ukraine); Sianoudis, I. [Department of Physics, Chemistry and Materials Technology, Technological Educational Institution of Athens, Aigaleo, 12210 Athens (Greece); Giokaris, N. [Physics Department National Capodistrian University of Athens, Panepistimioupolis Ilisia, 15771 Athens (Greece)]|[Institute of Accelerating Systems and Applications, P.O. Box 17214, 10024 Athens (Greece); Nomicos, C.D. [Department of Electronics, Technological Educational Institution of Athens, Aigaleo, 12210 Athens (Greece); Dimitropoulos, N. [Department of Medical Imaging, ' Euromedica' Medical Center, Mesogeion 2-4, 11527 Athens (Greece); Cavouras, D. [Department of Medical Instruments Technology, Technological Educational Institution of Athens, Ag. Spyridonos Street, Aigaleo, 12210 Athens (Greece); Panayiotakis, G. [Department of Medical Physics, Medical School, University of Patras, 26500 Patras (Greece); Kandarakis, I. [Department of Medical Instruments Technology, Technological Educational Institution of Athens, Ag. Spyridonos Street, Aigaleo, 12210 Athens (Greece)]. E-mail: kandarakis@teiath.gr

2006-12-20

The aim of the present study was to evaluate the imaging performance of YAP:Ce powder scintillating screens under exposure conditions employed in diagnostic radiology (50-140 kV). Various screens were prepared in our laboratory from YAP: Ce powder (Phosphor Technology, Ltd.), with coating thickness ranging from 53 to 110 mg/cm{sup 2}. The imaging performance of the screens was assessed by experimental determination of the modulation transfer function (MTF) and the noise transfer function (NTF). MTF was determined by the edge spread function (ESF) method while NTF was estimated by noise power spectrum (NPS) measurements after uniform screen irradiation. In addition, parameters related to overall image quality, such as the signal-to-noise ratio transfer (MTF/NTF), were estimated. MTF curves were affected by the beam hardening effects caused by the patient simulating 20 mm thick aluminum phantom. Under these conditions MTF values were found to increase with the mean X-ray photon energy. A similar effect was observed for NTF curves. Results were compared with data obtained on CsI:Tl scintillator. Taking into consideration the very fast response of YAP:Ce, these data may be of interest in designing X-ray imaging detectors.

Progress in GEM-based gaseous photomultipliers

CERN Document Server

Chechik, R; Breskin, Amos; Buzulutskov, A F; Guedes, G P; Mörmann, D; Singh, B K

2003-01-01

We discuss recent progress in gaseous photomultipliers (GPMTs) comprising UV-to-visible spectral range photocathodes (PCs) coupled to multiple Gas Electron Multipliers (GEM). The PCs may be either semitransparent or reflective ones directly deposited on the first-GEM surface. These detectors provide high gain, even in noble gases, are sensitive to single photons, have nanosecond time resolution, and offer good localization. The operation of CsI-based GPMTs in CF sub 4 opens new applications in Cherenkov detectors, where both the radiator and the photosensor operate in the same gas. The latest results on sealed visible-light detectors, combining bialkali PCs and Kapton-made GEMs are presented.

An efficient high-voltage power supply for a photomultiplier tube

NARCIS (Netherlands)

Ainutdinov, VM; Vonsovskii, NN; Kompaniets, KG; Kozyr, AI; Mikhailov, YV

2003-01-01

An adjustable power supply for a photomultiplier tube operating in the pulsed spectrometric mode with a wide range of linearity is described. The power consumed by the source is 50 mW. The output voltage is varied from 800 to 2000 V. The maximum ripple amplitude is 2.5 mV.

A silicon photomultiplier readout for time of flight neutron spectroscopy with {gamma}-ray detectors

Energy Technology Data Exchange (ETDEWEB)

Pietropaolo, A.; Gorini, G. [Dipartimento di Fisica ' ' G. Occhialini' ' and CNISM, Universita Degli Studi di Milano-Bicocca, Piazza della Scienza 3, 20126 Milano (Italy); Festa, G.; Andreani, C.; De Pascale, M. P.; Reali, E. [Dipartimento di Fisica and Centro NAST, Universita degli Studi di Roma Tor Vergata, Via della Ricerca Scientifica 1, 00133, Roma (Italy); Grazzi, F. [Istituto dei Sistemi Complessi-Consiglio Nazionale delle Ricerche, Via Madonna del Piano n.10, I-50019 Sesto Fiorentino, Firenze (Italy); Schooneveld, E. M. [ISIS Facility, Rutherford Appleton Laboratory, Chilton, Didcot, Oxfordshire, OX11 0QX (United Kingdom)

2009-09-15

The silicon photomultiplier (SiPM) is a recently developed photosensor used in particle physics, e.g., for detection of minimum ionizing particles and/or Cherenkov radiation. Its performance is comparable to that of photomultiplier tubes, but with advantages in terms of reduced volume and magnetic field insensitivity. In the present study, the performance of a gamma ray detector made of an yttrium aluminum perovskite scintillation crystal and a SiPM-based readout is assessed for use in time of flight neutron spectroscopy. Measurements performed at the ISIS pulsed neutron source demonstrate the feasibility of {gamma}-detection based on the new device.

Evaluation of methods for extraction of the volitional EMG in dynamic hybrid muscle activation

Directory of Open Access Journals (Sweden)

Mizrahi Joseph

2006-11-01

Full Text Available Abstract Background Hybrid muscle activation is a modality used for muscle force enhancement, in which muscle contraction is generated from two different excitation sources: volitional and external, by means of electrical stimulation (ES. Under hybrid activation, the overall EMG signal is the combination of the volitional and ES-induced components. In this study, we developed a computational scheme to extract the volitional EMG envelope from the overall dynamic EMG signal, to serve as an input signal for control purposes, and for evaluation of muscle forces. Methods A "synthetic" database was created from in-vivo experiments on the Tibialis Anterior of the right foot to emulate hybrid EMG signals, including the volitional and induced components. The database was used to evaluate the results obtained from six signal processing schemes, including seven different modules for filtration, rectification and ES component removal. The schemes differed from each other by their module combinations, as follows: blocking window only, comb filter only, blocking window and comb filter, blocking window and peak envelope, comb filter and peak envelope and, finally, blocking window, comb filter and peak envelope. Results and conclusion The results showed that the scheme including all the modules led to an excellent approximation of the volitional EMG envelope, as extracted from the hybrid signal, and underlined the importance of the artifact blocking window module in the process. The results of this work have direct implications on the development of hybrid muscle activation rehabilitation systems for the enhancement of weakened muscles.

A novel readout concept for multianode photomultiplier tubes with pad matrix anode layout

Energy Technology Data Exchange (ETDEWEB)

Popov, Vladimir [Thomas Jefferson National Accelerator Facility, Newport News, VA 23606 (United States)]. E-mail: Popov@jlab.org; Majewski, Stan [Thomas Jefferson National Accelerator Facility, Newport News, VA 23606 (United States); Welch, Benjamin L. [Thomas Jefferson National Accelerator Facility, Newport News, VA 23606 (United States)

2006-11-01

We have developed a new analog readout concept for multianode photomultiplier tubes with a pad matrix anode layout. This new readout technique is the result of a modification of a technique previously developed at the Detector Group of Jefferson Lab (V. Popov, US patent No: 6,747,263 B1) [V. Popov, S. Majewski, A.G. Weisenberger, Readout Electronics for Multianode Photomultiplier Tubes with Pad Matrix Anode Layout, Thomas Jefferson National Accelerator Facility, IEEE 2003 Medical Imaging Conference Record, November 2003]. The new analog readout circuit provides the same analog conversion of matrix 2-D output into X and Y projective output with a significant reduction of analog outputs. The old readout network consists of resistors' matrix and current collecting amplifiers, and it provides decoupling of each anode output into two directions (one to X and one to Y coordinates), but a decoupling function that is carried out independent of photomultiplier tube gains nonuniformity. A newly developed readout network (US patent pending) also consists of resistors' matrix and current collecting amplifiers, but the new matrix includes an additional dumping resistor that provides an excess current from anode pad grounding. As a result, we subtract an extra current of high-gain pads in order to move the pads gain to an absolute minimum value for a given photomultiplier tube. This gain equalization procedure reduces image distortion related to gain nonuniformity. The new readout technique was used in several new radiation imaging detectors designed in the Detector Group of Jefferson Lab. It shows a visible readout uniformity and linearity improvement. The test results of an initial evaluation of this readout that is applied for data readout of four H8500 Hamamtsu PSPMT are presented.

Fast tracking detector with fiber scintillators and a position sensitive photomultiplier

International Nuclear Information System (INIS)

Salomon, M.; Li, V.; Smith, G.; Wu, Y.S.

1988-11-01

We have studied the properties of a tracking detector composed of 32 fiber scintillators coupled to a multianode photomultiplier placed in a pion beam at TRIUMF. We measured the efficiency of the detector, as well as its tracking capabilities and double hit resolution

Pulse Shape Analysis and Discrimination for Silicon-Photomultipliers in Helium-4 Gas Scintillation Neutron Detector

Science.gov (United States)

Barker, Cathleen; Zhu, Ting; Rolison, Lucas; Kiff, Scott; Jordan, Kelly; Enqvist, Andreas

2018-01-01

Using natural helium (helium-4), the Arktis 180-bar pressurized gas scintillator is capable of detecting and distinguishing fast neutrons and gammas. The detector has a unique design of three optically separated segments in which 12 silicon-photomultiplier (SiPM) pairs are positioned equilaterally across the detector to allow for them to be fully immersed in the helium-4 gas volume; consequently, no additional optical interfaces are necessary. The SiPM signals were amplified, shaped, and readout by an analog board; a 250 MHz, 14-bit digitizer was used to examine the output pulses from each SiPMpair channel. The SiPM over-voltage had to be adjusted in order to reduce pulse clipping and negative overshoot, which was observed for events with high scintillation production. Pulse shaped discrimination (PSD) was conducted by evaluating three different parameters: time over threshold (TOT), pulse amplitude, and pulse integral. In order to differentiate high and low energy events, a 30ns gate window was implemented to group pulses from two SiPM channels or more for the calculation of TOT. It was demonstrated that pulses from a single SiPM channel within the 30ns window corresponded to low-energy gamma events while groups of pulses from two-channels or more were most likely neutron events. Due to gamma pulses having lower pulse amplitude, the percentage of measured gamma also depends on the threshold value in TOT calculations. Similarly, the threshold values were varied for the optimal PSD methods of using pulse amplitude and pulse area parameters. Helium-4 detectors equipped with SiPMs are excellent for in-the-field radiation measurement of nuclear spent fuel casks. With optimized PSD methods, the goal of developing a fuel cask content monitoring and inspection system based on these helium-4 detectors will be achieved.

Development of multi-channel high power rectangular RF window for LHCD system employing high temperature vacuum brazing technique

International Nuclear Information System (INIS)

Sharma, P K; Ambulkar, K K; Parmar, P R; Virani, C G; Thakur, A L; Joshi, L M; Nangru, S C

2010-01-01

A 3.7 GHz., 120 kW (pulsed), lower hybrid current drive (LHCD) system is employed to drive non-inductive plasma current in ADITYA tokamak. The rf power is coupled to the plasma through grill antenna and is placed in vacuum environment. A vacuum break between the pressurized transmission line and the grill antenna is achieved with the help of a multi (eight) channel rectangular RF vacuum window. The phasing between adjacent channels of 8-channel window (arranged in two rows) is important for launching lower hybrid waves and each channel should have independent vacuum window so that phase information is retained. The geometrical parameter of the grill antenna, like periodicity (9mm), channel dimensions (cross sectional dimension of 76mm x 7mm), etc. is to be maintained. These design constraint demanded a development of a multi channel rectangular RF vacuum window. To handle rf losses and thermal effects, high temperature vacuum brazing techniques is desired. Based on the above requirements we have successfully developed a multi channel rectangular rf vacuum window employing high temperature vacuum brazing technique. During the development process we could optimize the chemical processing parameters, brazing process parameters, jigs and fixtures for high temperature brazing and leak testing, etc. Finally the window is tested for low power rf performance using VNA. In this paper we would present the development of the said window in detail along with its mechanical, vacuum and rf performances.

Development of multi-channel high power rectangular RF window for LHCD system employing high temperature vacuum brazing technique

Energy Technology Data Exchange (ETDEWEB)

Sharma, P K; Ambulkar, K K; Parmar, P R; Virani, C G; Thakur, A L [Institute for Plasma Research, Bhat, Gandhinagar 382428 (India); Joshi, L M; Nangru, S C, E-mail: pramod@ipr.res.i [Central Electronics Engineering Research Institute, Pilani, Rajasthan 333 031 (India)

2010-02-01

A 3.7 GHz., 120 kW (pulsed), lower hybrid current drive (LHCD) system is employed to drive non-inductive plasma current in ADITYA tokamak. The rf power is coupled to the plasma through grill antenna and is placed in vacuum environment. A vacuum break between the pressurized transmission line and the grill antenna is achieved with the help of a multi (eight) channel rectangular RF vacuum window. The phasing between adjacent channels of 8-channel window (arranged in two rows) is important for launching lower hybrid waves and each channel should have independent vacuum window so that phase information is retained. The geometrical parameter of the grill antenna, like periodicity (9mm), channel dimensions (cross sectional dimension of 76mm x 7mm), etc. is to be maintained. These design constraint demanded a development of a multi channel rectangular RF vacuum window. To handle rf losses and thermal effects, high temperature vacuum brazing techniques is desired. Based on the above requirements we have successfully developed a multi channel rectangular rf vacuum window employing high temperature vacuum brazing technique. During the development process we could optimize the chemical processing parameters, brazing process parameters, jigs and fixtures for high temperature brazing and leak testing, etc. Finally the window is tested for low power rf performance using VNA. In this paper we would present the development of the said window in detail along with its mechanical, vacuum and rf performances.

Counting efficiency formulae for two, three or four photomultiplier systems

International Nuclear Information System (INIS)

Grau Malonda, A.

1993-01-01

Counting efficiency formulae as a function of the non-detection probability and the electron distributions for systems with two, three or dour photomultipliers are obtained in this paper. It is assumed that the photocathode electron emission follows the Poisson distribution. The obtained formulae are basic to compute the counting efficiency in liquid scintillation spectrometers

TEAD4-YAP interaction regulates tumoral growth by controlling cell-cycle arrest at the G1 phase

International Nuclear Information System (INIS)

Takeuchi, Shin; Kasamatsu, Atsushi; Yamatoji, Masanobu; Nakashima, Dai; Endo-Sakamoto, Yosuke; Koide, Nao; Takahara, Toshikazu; Shimizu, Toshihiro; Iyoda, Manabu; Ogawara, Katsunori; Shiiba, Masashi; Tanzawa, Hideki; Uzawa, Katsuhiro

2017-01-01

TEA domain transcription factor 4 (TEAD4), which has critical functions in the process of embryonic development, is expressed in various cancers. However, the important role of TEAD4 in human oral squamous cell carcinomas (OSCCs) remain unclear. Here we investigated the TEAD4 expression level and the functional mechanism in OSCC using quantitative reverse transcriptase-polymerase chain reaction, Western blot analysis, and immunohistochemistry. Furthermore, TEAD4 knockdown model was used to evaluate cellular proliferation, cell-cycle analysis, and the interaction between TEAD4 and Yes-associated protein (YAP) which was reported to be a transcription coactivator of cellular proliferation. In the current study, we found that TEAD4 expression increased significantly in vitro and in vivo and correlated with tumoral size in OSCC patients. TEAD4 knockdown OSCC cells showed decreased cellular proliferation resulting from cell-cycle arrest in the G1 phase by down-regulation of cyclins, cyclin-dependent kinases (CDKs), and up-regulation of CDK inhibitors. We also found that the TEAD4-YAP complex in the nuclei may be related closely to transcriptions of G1 arrest-related genes. Taken together, we concluded that TEAD4 might play an important role in tumoral growth and have potential to be a therapeutic target in OSCCs. - Highlights: • TEAD4 contributes to tumor progression in OSCCs. • TEAD4 knockdown results in cell-cycle arrest at the G1phase in OSCC cells. • In TEAD4 knockdown cells, the amount of YAP in the nucleus decreases. • Activation of the TEAD4-YAP complex is an important factor in OSCC tumor growth. • TEAD4 might be a critical biomarker and a therapeutic target for OSCCs.

Optimization of the digital Silicon Photomultiplier for Cherenkov light detection

International Nuclear Information System (INIS)

Frach, T

2012-01-01

The Silicon Photomultiplier is a promising alternative to fast vacuum photodetectors. We developed a fully digital implementation of the Silicon Photomultiplier. The sensor is based on a single photon avalanche photodiode (SPAD) integrated in a standard CMOS process. Photons are detected directly by sensing the voltage at the SPAD anode using a dedicated cell electronics block next to each diode. This block also contains active quenching and recharge circuits as well as a one bit memory for the selective inhibit of detector cells. A balanced trigger network is used to propagate the trigger signal from all cells to the integrated time-to-digital converter. Photons are detected and counted as digital signals, thus making the sensor less susceptible to temperature variations and electronic noise. The integration with CMOS logic has the added benefit of low power consumption and possible integration of data post-processing in the sensor. In this paper, we discuss the sensor architecture together with its characteristics, and its possible optimizations for applications requiring the detection of Cherenkov light.

Advances in CMOS solid-state photomultipliers for scintillation detector applications

Energy Technology Data Exchange (ETDEWEB)

Christian, James F.; Stapels, Christopher J.; Johnson, Erik B.; McClish, Mickel; Dokhale, Purushotthom; Shah, Kanai S.; Mukhopadhyay, Sharmistha; Chapman, Eric [Radiation Monitoring Devices, 44 Hunt Street, Watertownm, MA 02472 (United States); Augustine, Frank L., E-mail: JChristian@RMDInc.co [Augustine Engineering, 2115 Park Dale Ln, Encinitas, CA 92024 (United States)

2010-12-11

Solid-state photomultipliers (SSPMs) are a compact, lightweight, potentially low-cost alternative to a photomultiplier tube for a variety of scintillation detector applications, including digital-dosimeter and medical-imaging applications. Manufacturing SSPMs with a commercial CMOS process provides the ability for rapid prototyping, and facilitates production to reduce the cost. RMD designs CMOS SSPM devices that are fabricated by commercial foundries. This work describes the characterization and performance of these devices for scintillation detector applications. This work also describes the terms contributing to device noise in terms of the excess noise of the SSPM, the binomial statistics governing the number of pixels triggered by a scintillation event, and the background, or thermal, count rate. The fluctuations associated with these terms limit the resolution of the signal pulse amplitude. We explore the use of pixel-level signal conditioning, and characterize the performance of a prototype SSPM device that preserves the digital nature of the signal. In addition, we explore designs of position-sensitive SSPM detectors for medical imaging applications, and characterize their performance.

Preliminary studies of microchannel plate photomultiplier tube neutron detectors for flight test applications

International Nuclear Information System (INIS)

Dolan, K.W.

1978-10-01

Electrical, mechanical, thermal, and neutron response data indicate that microchannel plate photomultiplier tubes are viable candidates as miniature, ruggedized neutron detectors for flight test applications in future weapon systems

Silicon Photomultipliers: Dark Current and its Statistical Spread

Directory of Open Access Journals (Sweden)

Roberto PAGANO

2012-03-01

Full Text Available Aim of this paper is to investigate on a statistical basis at the wafer level the relationship existing among the dark currents of the single pixel compared to the whole Silicon Photomultiplier array. This is the first time to our knowledge that such a comparison is made, crucial to pass this new technology to the semiconductor manufacturing standards. In particular, emission microscopy measurements and current measurements allowed us to conclude that optical trenches strongly improve the device performances.

Modeling Photo-multiplier Gain and Regenerating Pulse Height Data for Application Development

Science.gov (United States)

Aspinall, Michael D.; Jones, Ashley R.

2018-01-01

Systems that adopt organic scintillation detector arrays often require a calibration process prior to the intended measurement campaign to correct for significant performance variances between detectors within the array. These differences exist because of low tolerances associated with photo-multiplier tube technology and environmental influences. Differences in detector response can be corrected for by adjusting the supplied photo-multiplier tube voltage to control its gain and the effect that this has on the pulse height spectra from a gamma-only calibration source with a defined photo-peak. Automated methods that analyze these spectra and adjust the photo-multiplier tube bias accordingly are emerging for hardware that integrate acquisition electronics and high voltage control. However, development of such algorithms require access to the hardware, multiple detectors and calibration source for prolonged periods, all with associated constraints and risks. In this work, we report on a software function and related models developed to rescale and regenerate pulse height data acquired from a single scintillation detector. Such a function could be used to generate significant and varied pulse height data that can be used to integration-test algorithms that are capable of automatically response matching multiple detectors using pulse height spectra analysis. Furthermore, a function of this sort removes the dependence on multiple detectors, digital analyzers and calibration source. Results show a good match between the real and regenerated pulse height data. The function has also been used successfully to develop auto-calibration algorithms.

Reduction of space charge effects and tests of larger samples of photomultipliers for the EDDA experiment

Science.gov (United States)

Ackerstaff, K.; Bisplinghoff, J.; Bollmann, R.; Cloth, P.; Dohrmann, F.; Diehl, O.; Dorner, G.; Drüke, V.; Engelhardt, H. J.; Eisenhardt, S.; Ernst, J.; Eversheim, P. D.; Filges, D.; Fritz, S.; Gasthuber, M.; Gebel, R.; Gross, A.; Gross-Hardt, R.; Hinterberger, F.; Jahn, R.; Lahr, U.; Langkau, R.; Lippert, G.; Mayer-Kuckuk, T.; Maschuw, R.; Mertler, G.; Metsch, B.; Mosel, F.; Paetz gen. Schieck, H.; Petry, H. R.; Prasuhn, D.; v. Przewoski, B.; Radtke, M.; Rohdjess, H.; Rosendaal, D.; von Rossen, P.; Scheid, H.; Schirm, N.; Schwandt, F.; Scobel, W.; Theis, D.; Weber, J.; Wiedmann, W.; Woller, K.; Ziegler, R.; EDDA Collaboration

1993-10-01

For the EDDA experiment at COSY, the response of the small, linear focused photomultipliers Hamamatsu R 1450 and R 1355 has been studied with fast light pulses generating yields up to 2 × 10 3 photoelectrons/cm 2 or peak currents of 24 mA. Linearity was obtained with a tapered bleeder chain at a tolerable loss of gain. The serial test of altogether 140 photomultipliers revealed the close correlation between single electron and amplitude resolution. The influence of the photoelectron statistics on this correlation is discussed.

The design of the detector and collimators for a hybrid scanner

International Nuclear Information System (INIS)

Vauramo, E.; Virjo, A.

1977-01-01

The hybrid scanner is a scanning device in which a long crystal with two or more photomultiplier (PM) tubes acts as a gamma camera along the crystal axis; the device acts as a linear scanner in a direction perpendicular to the crystal axis. A detailed analysis of the intrinsic resolution and uniformity is given for a two-PM-tube hybrid scanner (with one PM tube at each end) and the expressions derived should help the designer to choose the best crystal system. Collimation theory is discussed for the general hybrid scanner. Expressions and graphs are given to help in the design of a collimator with the best balance between the conflicting requirements of resolution, sensitivity, depth independence and freedom from artifacts (collimator holes may be seen in the image at high energy). Examples of practical collimators are given for energies of 80 to 140, 364, 511, 662 and 840 keV. (author)

Development of an external readout electronics for a hybrid photon detector

CERN Document Server

Uyttenhove, Simon; Tichon, Jacques; Garcia, Salvador

The pixel hybrid photon detectors currently installed in the LHCb Cherenkov system encapsulate readout electronics in the vacuum tube envelope. The LHCb upgrade and the new trigger system will require their replacement with new photon detectors. The baseline photon detector candidate is the multi-anode photomultiplier. A hybrid photon detector with external readout electronics has been proposed as a backup option. This master thesis covers a R & D phase to investigate this latter concept. Extensive studies of the initial electronics system underlined the noise contributions from the Beetle chip used as front-end readout ASIC and from the ceramic carrier of the photon detector. New front-end electronic boards have been developed and made fully compatible with the existing LHCb-RICH infrastructure. With this compact readout system, Cherenkov photons have been successfully detected in a real particle beam environment. The proof-of-concept of a hybrid photon detector with external readout electronics was val...

Geology and geochemistry of epithermal precious metal vein systems in the intra-oceanic arcs of Palau and Yap, western Pacific

Science.gov (United States)

Rytuba, J.J.; Miller, W.R.

1990-01-01

The Palau and Yap arcs are part of an intra-oceanic island-arc-trench system which separates the Pacific and Philippine plates in the western Pacific Ocean. The 350-km-long Palau arc consists of over 200 islands while the 400-km-long Yap arc located to the north has only four major islands exposed. Four of the largest islands in Palau are composed primarily of early Eocene to mid-Miocene volcanic rocks and the four islands comprising Yap contain only Miocene volcanic rocks. Basalt and basaltic andesites of the Babelthuap Formation are the oldest volcanic rocks in Palau and are characterized by high MgO, Ni and Cr and low TiO2 and have a boninitic affinity. They form the central and southeastern parts of Babelthuap Island. Oligocene arc tholeiite flows having an age of 34-35.5 Ma comprise most of the three smaller volcanic islands in Palau and the western part of Babelthuap. The youngest volcanic rocks are dacitic intrusions having an age of 22.7-23.2 Ma. The Yap arc is unusual in that metamorphic rocks up to amphibolite grade form most of the islands. These are underlain by a melange composed of igneous and volcanic clasts as well as clasts from a dismembered copper-gold skarn deposit. Miocene volcanic rocks consisting of flows and volcaniclastic deposits overlie the melange and metamorphic complex. An epithermal precious-metal vein system hosted by flows and flow breccias of the Babelthuap Formation occurs in an area 1.5 km by 1 km on the southeast side of Babelthuap Island. Over 50 veins and mineralized breccias ranging up to 2 m in width and having a strike length up to 500 m contain from trace to 13.0 ppm gold. The veins consist of quartz with varying amounts of sulfides and iron oxides after sulfides and the mineralized breccias consist of brecciated country rock cemented by quartz and iron oxides after sulfides. The veins and mineralized breccias generally dip within 15?? of vertical and have two preferred orientations, north-northwest and north

Farklı Durum Çeşitlerinden Mahalli ve Laboratuvar Koşullarında Yapılmış Bulguların Bazı Vitamin ve Mineral İçerikleri

Directory of Open Access Journals (Sweden)

Berrin Özkaya

2015-02-01

Full Text Available Araştırmada 5 farklı durum buğdayının, bunlardan mahalli ve laboratuvar koşullarında yapılan bulguların bazı kimyasal özellikleri ile tiamin, riboflavin ve mineral içerikleri karşılaştırılmıştır. Buğdayların yapımı sırasında buğdayların tiamin, özellikle de riboflavin miktarları azalmıştır. Mahalli koşullarda yapılan bulgurların tiamin ve riboflavin miktarları laboratuvarda yapılanlara kıyasla biraz düşük çıkmıştır. Bulgurların mineral içerikleri (Fe, Cu, Zn, Mn, Ca ve Mg miktarları yapıldıktan buğdaylara kıyasla daha düşük çıkmış, mahalli ve laboratuvar koşullarında yapılan bulgurların mineral madde miktarlarında önemli bir fark görülmemiştir.

Strategies of statistical windows in PET image reconstruction to improve the user’s real time experience

Science.gov (United States)

Moliner, L.; Correcher, C.; Gimenez-Alventosa, V.; Ilisie, V.; Alvarez, J.; Sanchez, S.; Rodríguez-Alvarez, M. J.

2017-11-01

Nowadays, with the increase of the computational power of modern computers together with the state-of-the-art reconstruction algorithms, it is possible to obtain Positron Emission Tomography (PET) images in practically real time. These facts open the door to new applications such as radio-pharmaceuticals tracking inside the body or the use of PET for image-guided procedures, such as biopsy interventions, among others. This work is a proof of concept that aims to improve the user experience with real time PET images. Fixed, incremental, overlapping, sliding and hybrid windows are the different statistical combinations of data blocks used to generate intermediate images in order to follow the path of the activity in the Field Of View (FOV). To evaluate these different combinations, a point source is placed in a dedicated breast PET device and moved along the FOV. These acquisitions are reconstructed according to the different statistical windows, resulting in a smoother transition of positions for the image reconstructions that use the sliding and hybrid window.

Silicon photomultipliers for positron emission tomography detectors with depth of interaction encoding capability

International Nuclear Information System (INIS)

Taghibakhsh, Farhad; Reznik, Alla; Rowlands, John A.

2011-01-01

Silicon photomultipliers (SiPMs) are receiving increasing attention in the field of positron emission tomography (PET) detectors. Compared to photomultiplier tubes, they offer novel detector configurations for the extraction of depth of interaction (DOI) information, or enable emerging medical imaging modalities such as simultaneous PET-magnetic resonant imaging (MRI). In this article, we used 2x2x20 mm 3 LYSO scintillator crystals coupled to SiPMs on both ends (dual-ended readout configuration) to evaluate the detector performance for DOI-PET applications. We investigated the effect of scintillator crystal surface finishing on sensitivity and resolution of DOI, as well as on energy and timing resolution. Measurements indicate DOI sensitivity and resolution of 7.1% mm -1 and 2.1±0.6 mm for saw-cut, and 1.3% mm -1 and 9.0±1.5 mm, for polished scintillator crystals, respectively. Energy resolution varies from 19% when DOI is in the center, to 15% with DOI at either end of the saw-cut crystal, while it remains constant at ∼14% for polished scintillators. Based on our results we conclude that 2x2x20 mm 3 saw-cut (without any special side wall polishing) LYSO crystals coupled to 2x2 mm 2 silicon photomultipliers are optimal for isotropic 2 mm resolution DOI-PET applications.

Learning Windows Azure Mobile Services for Windows 8 and Windows Phone 8

CERN Document Server

Webber-Cross, Geoff

2014-01-01

This book is based around a case study game which was written for the book. This means that the chapters progress in a logical way and build upon lessons learned as we go. Real-world examples are provided for each topic that are practical and not given out-of-context so they can be applied directly to other applications.If you are a developer who wishes to build Windows 8 and Phone 8 applications and integrate them with Windows Azure Mobile Services, this book is for you. Basic C# and JavaScript skills are advantageous, as well as some knowledge of building Windows 8 or Windows Phone 8 applica

Characterization of a prototype matrix of Silicon PhotoMultipliers

Energy Technology Data Exchange (ETDEWEB)

Dinu, N. [Laboratory of Linear Accelerator (LAL), IN2P3-CNRS, 91898 Orsay (France)], E-mail: dinu@lal.in2p3.fr; Barrillon, P.; Bazin, C. [Laboratory of Linear Accelerator (LAL), IN2P3-CNRS, 91898 Orsay (France); Belcari, N.; Bisogni, M.G. [Universita di Pisa, Dipartimento di Fisica ' E. Fermi' , 56127 Pisa (Italy); INFN, Sezione di Pisa, 56127 Pisa (Italy); Bondil-Blin, S. [Laboratory of Linear Accelerator (LAL), IN2P3-CNRS, 91898 Orsay (France); Boscardin, M. [Fondazione Bruno Kessler (FBK-irst), 38050 Trento (Italy); Chaumat, V. [Laboratory of Linear Accelerator (LAL), IN2P3-CNRS, 91898 Orsay (France); Collazuol, G. [Scuola Normale Superiore (SNS), 56127 Pisa (Italy); INFN, Sezione di Pisa, 56127 Pisa (Italy); De La Taille, C. [Laboratory of Linear Accelerator (LAL), IN2P3-CNRS, 91898 Orsay (France); Del Guerra, A. [Universita di Pisa, Dipartimento di Fisica ' E. Fermi' , 56127 Pisa (Italy); INFN, Sezione di Pisa, 56127 Pisa (Italy); Llosa, G. [Universita di Pisa, Dipartimento di Fisica ' E. Fermi' , 56127 Pisa (Italy); Marcatili, S. [Universita di Pisa, Dipartimento di Fisica ' E. Fermi' , 56127 Pisa (Italy); INFN, Sezione di Pisa, 56127 Pisa (Italy); Melchiorri, M.; Piemonte, C. [Fondazione Bruno Kessler (FBK-irst), 38050 Trento (Italy); Puill, V. [Laboratory of Linear Accelerator (LAL), IN2P3-CNRS, 91898 Orsay (France); Tarolli, A. [Fondazione Bruno Kessler (FBK-irst), 38050 Trento (Italy); Vagnucci, J.F. [Laboratory of Linear Accelerator (LAL), IN2P3-CNRS, 91898 Orsay (France); Zorzi, N. [Fondazione Bruno Kessler (FBK-irst), 38050 Trento (Italy)

2009-10-21

This work reports on the electrical as well as the optical characterizations of a prototype matrix of Silicon PhotoMultipliers (SiPM). The electrical test consists of the measurement of the static (breakdown voltage, quenching resistance, post-breakdown dark current) as well as the dynamic characteristics (gain, dark count rate). The optical test consists of the estimation of the photon detection efficiency as a function of wavelength as well as operation voltage.

Characterization of a prototype matrix of Silicon PhotoMultipliers

International Nuclear Information System (INIS)

Dinu, N.; Barrillon, P.; Bazin, C.; Belcari, N.; Bisogni, M.G.; Bondil-Blin, S.; Boscardin, M.; Chaumat, V.; Collazuol, G.; De La Taille, C.; Del Guerra, A.; Llosa, G.; Marcatili, S.; Melchiorri, M.; Piemonte, C.; Puill, V.; Tarolli, A.; Vagnucci, J.F.; Zorzi, N.

2009-01-01

This work reports on the electrical as well as the optical characterizations of a prototype matrix of Silicon PhotoMultipliers (SiPM). The electrical test consists of the measurement of the static (breakdown voltage, quenching resistance, post-breakdown dark current) as well as the dynamic characteristics (gain, dark count rate). The optical test consists of the estimation of the photon detection efficiency as a function of wavelength as well as operation voltage.

Wrinkled Graphene–AgNWs Hybrid Electrodes for Smart Window

Directory of Open Access Journals (Sweden)

Ki-Woo Jun

2017-02-01

Full Text Available Over the past few years, there has been an increasing demand for stretchable electrodes for flexible and soft electronic devices. An electrode in such devices requires special functionalities to be twisted, bent, stretched, and deformed into variable shapes and also will need to have the capacity to be restored to the original state. In this study, we report uni- or bi-axially wrinkled graphene–silver nanowire hybrid electrodes comprised of chemical vapor deposition (CVD-grown graphene and silver nanowires. A CVD-grown graphene on a Cu-foil was transferred onto a biaxially pre-strained elastomer substrate and silver nanowires were sprayed on the transferred graphene surface. The pre-strained film was relaxed uni-(or bi-axially to produce a wrinkled structure. The bi-axially wrinkled graphene and silver nanowires hybrid electrodes were very suitable for high actuating performance of electro-active dielectric elastomers compared with the wrinkle-free case. Present results show that the optical transparency of the highly stretchable electrode can be successfully tuned by modulating input voltages.

Muon tracking system with Silicon Photomultipliers

International Nuclear Information System (INIS)

Arneodo, F.; Benabderrahmane, M.L.; Dahal, S.; Di Giovanni, A.; Pazos Clemens, L.; Candela, A.; D'Incecco, M.; Sablone, D.; Franchi, G.

2015-01-01

We report the characterisation and performance of a low cost muon tracking system consisting of plastic scintillator bars and Silicon Photomultipliers equipped with a customised front-end electronics based on a fast preamplifier network. This system can be used as a detector test bench for astroparticle physics and for educational and outreach purposes. We investigated the device behaviour in self-trigger and coincidence mode, without using LED and pulse generators, showing that with a relatively simple set up a complete characterisation work can be carried out. A high definition oscilloscope, which can easily be found in many university physics or engineering departments, has been used for triggering and data acquisition. Its capabilities have been exploited to discriminate real particles from the background

Muon tracking system with Silicon Photomultipliers

Energy Technology Data Exchange (ETDEWEB)

Arneodo, F.; Benabderrahmane, M.L.; Dahal, S. [New York University Abu Dhabi, Abu Dhabi (United Arab Emirates); Di Giovanni, A., E-mail: adriano.digiovanni@nyu.edu [New York University Abu Dhabi, Abu Dhabi (United Arab Emirates); Pazos Clemens, L. [New York University Abu Dhabi, Abu Dhabi (United Arab Emirates); Candela, A.; D' Incecco, M.; Sablone, D. [Gran Sasso National Laboratory of INFN, Assergi (Italy); Franchi, G. [AGE Scientific Srl, Capezzano Pianore (Italy)

2015-11-01

We report the characterisation and performance of a low cost muon tracking system consisting of plastic scintillator bars and Silicon Photomultipliers equipped with a customised front-end electronics based on a fast preamplifier network. This system can be used as a detector test bench for astroparticle physics and for educational and outreach purposes. We investigated the device behaviour in self-trigger and coincidence mode, without using LED and pulse generators, showing that with a relatively simple set up a complete characterisation work can be carried out. A high definition oscilloscope, which can easily be found in many university physics or engineering departments, has been used for triggering and data acquisition. Its capabilities have been exploited to discriminate real particles from the background.

The LED and fiber based calibration system for the photomultiplier array of SNO+

Science.gov (United States)

Seabra, L.; Alves, R.; Andringa, S.; Bradbury, S.; Carvalho, J.; Clark, K.; Coulter, I.; Descamps, F.; Falk, L.; Gurriana, L.; Kraus, C.; Lefeuvre, G.; Maio, A.; Maneira, J.; Mottram, M.; Peeters, S.; Rose, J.; Sinclair, J.; Skensved, P.; Waterfield, J.; White, R.; Wilson, J.; SNO+ Collaboration

2015-02-01

A new external LED/fiber light injection calibration system was designed for the calibration and monitoring of the photomultiplier array of the SNO+ experiment at SNOLAB. The goal of the calibration system is to allow an accurate and regular measurement of the photomultiplier array's performance, while minimizing the risk of radioactivity ingress. The choice in SNO+ was to use a set of optical fiber cables to convey into the detector the light pulses produced by external LEDs. The quality control was carried out using a modified test bench that was used in QC of optical fibers for TileCal/ATLAS. The optical fibers were characterized for transmission, timing and angular dispersions. This article describes the setups used for the characterization and quality control of the system based on LEDs and optical fibers and their results.

Replacement of a photomultiplier tube in a 2-inch thallium-doped sodium iodide gamma spectrometer with silicon photomultipliers and a light guide

Directory of Open Access Journals (Sweden)

Chankyu Kim

2015-06-01

Full Text Available The thallium-doped sodium iodide [NaI(Tl] scintillation detector is preferred as a gamma spectrometer in many fields because of its general advantages. A silicon photomultiplier (SiPM has recently been developed and its application area has been expanded as an alternative to photomultiplier tubes (PMTs. It has merits such as a low operating voltage, compact size, cheap production cost, and magnetic resonance compatibility. In this study, an array of SiPMs is used to develop an NaI(Tl gamma spectrometer. To maintain detection efficiency, a commercial NaI(Tl 2′ × 2′ scintillator is used, and a light guide is used for the transport and collection of generated photons from the scintillator to the SiPMs without loss. The test light guides were fabricated with polymethyl methacrylate and reflective materials. The gamma spectrometer systems were set up and included light guides. Through a series of measurements, the characteristics of the light guides and the proposed gamma spectrometer were evaluated. Simulation of the light collection was accomplished using the DETECT 97 code (A. Levin, E. Hoskinson, and C. Moison, University of Michigan, USA to analyze the measurement results. The system, which included SiPMs and the light guide, achieved 14.11% full width at half maximum energy resolution at 662 keV.

Characterization of three high efficiency and blue sensitive silicon photomultipliers

Energy Technology Data Exchange (ETDEWEB)

Otte, Adam Nepomuk, E-mail: otte@gatech.edu; Garcia, Distefano; Nguyen, Thanh; Purushotham, Dhruv

2017-02-21

We report about the optical and electrical characterization of three high efficiency and blue sensitive Silicon photomultipliers from FBK, Hamamatsu, and SensL. Key features of the tested devices when operated at 90% breakdown probability are peak photon detection efficiencies between 40% and 55%, temperature dependencies of gain and PDE that are less than 1%/°C, dark rates of ∼50 kHz/mm{sup 2} at room temperature, afterpulsing of about 2%, and direct optical crosstalk between 6% and 20%. The characteristics of all three devices impressively demonstrate how the Silicon-photomultiplier technology has improved over the past ten years. It is further demonstrated how the voltage and temperature characteristics of a number of quantities can be parameterized on the basis of physical models. The models provide a deeper understanding of the device characteristics over a wide bias and temperature range. They also serve as examples how producers could provide the characteristics of their SiPMs to users. A standardized parameterization of SiPMs would enable users to find the optimal SiPM for their application and the operating point of SiPMs without having to perform measurements thus significantly reducing design and development cycles.

Wide aperture scintillation hodoscope with FEU-143 photomultipliers

International Nuclear Information System (INIS)

Afanas'ev, L.G.; Ivanov, M.A.; Karpukhin, V.V.; Komarov, V.I.; Kulikov, A.V.; Yazkov, V.V.

1993-01-01

Scintillation hodoscopes with FEU-143 photomultipliers are described. Every of two hodoscopes consists of 8 elements each of length 1400 mm and cross section 56x56 mm. The time and amplitude characteristics were obtained in real conditions of the physical experiment at the Protvino U-70 accelerator. A resolution on time difference between hits of two hodoscopes is 224 ps. A separation of pions and protons by their ionization losses is also provided at momenta less than 1000 MeV/c. 5 refs.; 8 figs.; 1 tab

An innovative silicon photomultiplier digitizing camera for gamma-ray astronomy

Czech Academy of Sciences Publication Activity Database

Heller, M.; Schioppa, E.jr.; Porcelli, A.; Pujadas, I.T.; Zietara, K.; della Volpe, D.; Montaruli, T.; Cadoux, F.; Favre, Y.; Aguilar, J.A.; Christov, A.; Prandini, E.; Rajda, P.; Rameez, M.; Bilnik, W.; Blocki, J.; Bogacz, L.; Borkowski, J.; Bulik, T.; Frankowski, A.; Grudzinska, M.; Idzkowski, B.; Jamrozy, M.; Janiak, M.; Kasperek, J.; Lalik, K.; Lyard, E.; Mach, E.; Mandát, Dušan; Marszalek, A.; Medina Miranda, L. D.; Michałowski, J.; Moderski, R.; Neronov, A.; Niemiec, J.; Ostrowski, M.; Pasko, P.; Pech, Miroslav; Schovánek, Petr; Seweryn, K.; Sliusar, V.; Skowron, K.; Stawarz, L.; Stodulska, M.; Stodulski, M.; Walter, R.; Wiecek, M.; Zagdanski, A.

2017-01-01

Roč. 77, č. 1 (2017), s. 1-31, č. článku 47. ISSN 1434-6044 R&D Projects: GA MŠk LE13012; GA MŠk LG14019 Institutional support: RVO:68378271 Keywords : silicon photomultiplier * digitizing camera * gamma-ray astronomy Subject RIV: BF - Elementary Particles and High Energy Physics OBOR OECD: Particles and field physics Impact factor: 5.331, year: 2016

An amplifier for VUV photomultiplier operating in cryogenic environment

International Nuclear Information System (INIS)

Arneodo, F.; Benabderrahmane, M.L.; Dahal, S.; Di Giovanni, A.; D'Inzeo, M.; Franchi, G.; Pazos Clemens, L.

2016-01-01

We present the characterisation of an amplifier potentially interesting for noble liquid detectors. The design has been conceived considering the requirements of low power consumption (less than 30 mW), low noise, amplification factor of 10 at 100 MHz and use of commercial components. The amplifier has been integrated onto an electronic board with a voltage divider to operate an Hamamatsu R11410 photomultiplier tube (used in XENON1T, Aprile et al. (2014) [1] dark matter experiment).

An amplifier for VUV photomultiplier operating in cryogenic environment

Energy Technology Data Exchange (ETDEWEB)

Arneodo, F.; Benabderrahmane, M.L.; Dahal, S. [New York University Abu Dhabi, Abu Dhabi (United Arab Emirates); Di Giovanni, A., E-mail: adriano.digiovanni@nyu.edu [New York University Abu Dhabi, Abu Dhabi (United Arab Emirates); D' Inzeo, M.; Franchi, G. [Age Scientific srl – Capezzano Pianore (Italy); Pazos Clemens, L. [New York University Abu Dhabi, Abu Dhabi (United Arab Emirates)

2016-07-11

We present the characterisation of an amplifier potentially interesting for noble liquid detectors. The design has been conceived considering the requirements of low power consumption (less than 30 mW), low noise, amplification factor of 10 at 100 MHz and use of commercial components. The amplifier has been integrated onto an electronic board with a voltage divider to operate an Hamamatsu R11410 photomultiplier tube (used in XENON1T, Aprile et al. (2014) [1] dark matter experiment).

Windows server cookbook for Windows server 2003 and Windows 2000

CERN Document Server

Allen, Robbie

2005-01-01

This practical reference guide offers hundreds of useful tasks for managing Windows 2000 and Windows Server 2003, Microsoft's latest server. These concise, on-the-job solutions to common problems are certain to save you many hours of time searching through Microsoft documentation. Topics include files, event logs, security, DHCP, DNS, backup/restore, and more

Kefir Kültürünün Beyaz Peynir Yapımında Kullanılması Üzerine bir Araştırma

Directory of Open Access Journals (Sweden)

Hasan Yaygın

2015-02-01

Full Text Available Beyaz peynir yapımında kullanılacak saf kültürde yer alması gereken mikroorganizmaları saptamak amacı ile bazı çalışmalar yapılmıştır. Araştırıcıların çoğunluğu saf kültürde S. lactis, S. cremoris ve L. casei’ nin bulunması gerektiğini belirtmişlerdir. Bu çalışmada beyaz peynir yapımında saf kültür olarak kefir kültürü kullanılmıştır. Kefir kültüründe söz konusu bakterilerle beraber bazı maya ve bakteriler de bulunmaktadır. Araştırma sonuçları kefir kültürü katılan sütten yapılan beyaz peynirde asitlik gelişiminin istenilen düzeyde olduğu; tat ve aroma ile yapının tüketiciler tarafından beğenildiğini ortaya çıkarmıştır.

Denizli İlinde İhracatı Yapılan Mantarlar

Directory of Open Access Journals (Sweden)

Kutret GEZER

2016-01-01

Full Text Available Mantarlar protein, karbonhidrat, vitamin ve mineral gibi besinler yönünden zengin içeriğe sahip olmalarının yanı sıra farklı lezzetleriyle, yüzyıllardır insanoğlu için iyi bir besin kaynağı olmuştur. Ayrıca içerdikleri pek çok aktif bileşenin teröpatik etkilerinin bulunması besinsel değerlerini de arttırmaktadır. Ancak taze mantarların raf ömrünün kısa olması, kolay bozulmaları ve her dönemde bulunamamaları gibi bazı olumsuzluklar mantarların gıda sektöründe kullanım alanlarını sınırlamaktadır. Taze tüketime alternatif yöntemlerden biri olan kurutulmuş mantarların kullanımı dünya genelinde giderek yaygınlaşmaktadır. Mantarlar kurutulduğunda tat ve diğer özelliklerini büyük oranda korumaktadırlar. Kurutulmuş mantarlar, öğütülerek toz halinde veya bütün olarak doğrudan tüketilebildiği gibi tatlı, baharat, garnitür, mama, pizza ve çorbalara katılarak çeşitli şekillerde de tüketilebilmektedir. Ülkemizde 2007 yılında 21 ton kurutulmuş mantar ihracatı gerçekleşmiş ve 1.71 milyon dolar ülke ekonomisine katkı sağlanmıştır. Denizli ili kuru veya şoklanmış mantar ihracatında önemli bir yere sahiptir. Bu çalışmada Denizli ilinde kurutularak ihracatı yapılan Boletus edulis, Morchella esculenta, Cantharellus cibarius ve Craterellus cornucopioides türlerinin genel özellikleri ve besin içerikleriyle ilgili bilgilerin verilmesi amaçlanmıştır. Araştırma için konuyla ilgili son zamanlarda yapılmış çalışmalara ulaşılarak yazın taraması yapılmıştır. Bu çalışmaya konu olan mantar türleriyle ilgili bulgular arasındaki ilişkiler göz önüne alınarak, elde edilen veriler bir araya getirilmiş ve yorumlanmıştır.

Sensitivity of a multi-photomultiplier optical module for KM3NeT

NARCIS (Netherlands)

Löhner, H.; Mjos, A.

2009-01-01

For the KM3NeT neutrino telescope an optical module with a number of small photomultiplier tubes (multi-PMT optical module) will be advantageous for various reasons, e.g. reduced background rate, a larger number of coincidence hits, and sensitivity to ultra-high energy neutrinos. The properties of

MS Windows domēna darbstaciju migrācija no MS Windows XP uz Windows Vista.

OpenAIRE

Tetere, Agate

2009-01-01

Kvalifikācijas darbā izpētīju darbstaciju migrācijas no Windows XP uz Windows Vista plusus un mīnusus. Darba gaitā tika veikti sekojoši uzdevumi: 1.Veikta Windows XP un Windows Vista darbstaciju instalācija, iestatījumu konfigurēšana un tika pārbaudīta sistēmas darbība 2.Veikta Windows Server 2003 un Windows Server 2008 instalācija, iestatījumu konfigurēšana un tika pārbaudīta sistēmas darbība 3.Izstrādāts migrācijas modelis 4.Veikta migrācijas optimizēšana 5.Veikta datu migrāc...

Strategies for shortening the output pulse of silicon photomultipliers

OpenAIRE

Antoranz Canales, Pedro; Miranda Pantoja, José Miguel; Yebras Rivera, José Manuel

2012-01-01

In this work, three strategies for shortening the output pulse of a silicon photomultiplier (SiPM) are reported. The first strategy is passive filtering, where band-pass filtering removes the lowest frequency components in the signal, getting a noticeable reduction in pulse width (a compression ratio of 10: 1 was obtained). In the second place, a reflectometric scheme is proposed where the amplified signal coming from the SiPM is injected into a signal splitter with one of its stubs connected...

Tekstilde Yeni Bir Konsept Olan Dendrimerlerin Tarihçesi, Sınıflandırılması, Molekül Yapısı ve Özellikleri

Directory of Open Access Journals (Sweden)

Osman NAMIRTI

2011-02-01

Full Text Available Son 20 yıldır polimer kimyası tarafından çok sayıda lineer olmayan yapılar ortaya çıkartılmış ve polimer sentezi sırasında çok sayıda yan dalların eklenmesi, çok sayıda uç gruplara sahip makromoleküllerin eldesine yol açmıştır. Bu polimerlerin iki tipi, düzgün yapıda dallanmış "dendrimer"ler ile dallanmanın rastgele oluştuğu "hiperdallanmış moleküller"dir. Bu makalede özel yapıları nedeniyle tekstilde de çeşitli uygulama alanları bulan dendrimerlerin tarihçesi, sınıflandırılması, molekül yapısı ve özellikleri hakkında bilgi verilmektedir.

Sub-millimeter planar imaging with positron emitters: EGS4 code simulation and experimental results

International Nuclear Information System (INIS)

Bollini, D.; Del Guerra, A.; Di Domenico, G.

1996-01-01

Experimental data for Planar Imaging with positron emitters (pulse height, efficiency and spatial resolution) obtained with two matrices of 25 crystals (2 x 2 x 30 mm 3 each) of YAP:Ce coupled with a Position Sensitive PhotoMultiplier (Hamamatsu R2486-06) have been reproduced with high accuracy using the EGS4 code. Extensive simulation provides a detailed description of the performance of this type of detector as a function of the matrix granularity, the geometry of the detector and detection threshold. We present the Monte Carlo simulation and the preliminary experimental results of a prototype planar imaging system made of two matrices, each one consisting of 400 (2 x 2 x 30 mm 3 ) crystals of YAP-Ce

Light programmable organic transistor memory device based on hybrid dielectric

Science.gov (United States)

Ren, Xiaochen; Chan, Paddy K. L.

2013-09-01

We have fabricated the transistor memory devices based on SiO2 and polystyrene (PS) hybrid dielectric. The trap states densities with different semiconductors have been investigated and a maximum 160V memory window between programming and erasing is realized. For DNTT based transistor, the trapped electron density is limited by the number of mobile electrons in semiconductor. The charge transport mechanism is verified by light induced Vth shift effect. Furthermore, in order to meet the low operating power requirement of portable electronic devices, we fabricated the organic memory transistor based on AlOx/self-assembly monolayer (SAM)/PS hybrid dielectric, the effective capacitance of hybrid dielectric is 210 nF cm-2 and the transistor can reach saturation state at -3V gate bias. The memory window in transfer I-V curve is around 1V under +/-5V programming and erasing bias.

Actively-stabilized photomultiplier tube base for vacuum operation

International Nuclear Information System (INIS)

Bryan, M.A; Morris, C.L.; Idzorek, G.C.

1992-01-01

An actively stabilized photomultiplier tube (PMT) base design for an Amperex XP-2262B PMT is described. Positive-negative-positive transistors are used as low-impedance current sources to maintain constant voltages on the last three dynodes. This technique results in a highly stable, low-power tube base ideal for use with low-duty-factor beams, such as those found at the Clinton P. Anderson Meson Physics Facility. Furthermore, because of the low power usage of this large design, these bases can be sealed in a heat-conductive, electrically insulating material and used in a vacuum

Grab Windows training opportunities; check CERN Windows roadmap!

CERN Multimedia

IT Department

2011-01-01

CERN Operating Systems and Information Services group (IT-OIS) actively monitors market trends to check how new software products correspond to CERN needs. In the Windows world, Windows 7 has been a big hit, with over 1500 Windows 7 PCs within less than a year since its support was introduced at CERN. No wonder: Windows XP is nearly 10 years old and is steadily approaching the end of its life-cycle. At CERN, support for Windows XP will stop at the end of December 2012. Compared to Vista, Windows 7 has the same basic hardware requirements, but offers higher performance, so the decision to upgrade is rather straightforward. CERN support for Vista will end in June 2011. In the world of Microsoft Office, version 2007 offers better integration with the central services than the older version 2003. Progressive upgrade from 2003 to 2007 is planned to finish in September 2011, but users are encouraged to pro-actively upgrade at their convenience. Please note that Office 2007 brings an important change in the area of ...

23 Ekim 2011 Tabanlı-Van Depreminin Sismik Jeomorfolojisi ve Doğu Anadolu’daki Aktif Tektonik Yapılarla Olan İlişkisi

OpenAIRE

Özkaymak, Çağlar; Sözbilir, Hasan; Bozkurt, Erdin; Dirik, Kadir; Topal, Tamer; Alan, Hüseyin; Çağlan, Dündar

2011-01-01

Bu çalışma, 23 Ekim 2011 tarihindemeydana gelen Tabanlı-Van (M = 7.2) depreminin bölgenin aktif tektoniğiiçerisindeki konumunu açıklamayı amaçlamaktadır. Bu bağlamda Tabanlı-Van depremindensonra arazi çalışmaları yapılmış, depremle ilişkili deformasyon yapılarıincelenmiş ve arazi gözlemlerinden elde edilen veriler ile Van ili veçevresiyle ilgili olarak daha önce yapılmış aktif tektonik çalışmalarıkarşılaştırılarak değerlendirmeye gidilmiştir. Depremsırasında veya hemen sonrasında yeryüzünde/y...

17-AAG suppresses growth and invasion of lung adenocarcinoma cells via regulation of the LATS1/YAP pathway

Science.gov (United States)

Ye, Xiang-Yun; Luo, Qing-Quan; Xu, Yun-Hua; Tang, Nai-Wang; Niu, Xiao-Min; Li, Zi-Ming; Shen, Sheng-Ping; Lu, Shun; Chen, Zhi-Wei

2015-01-01

The large tumour suppressor 1 (LATS1) signalling network has been proved to be an essential regulator within the cell, participating in multiple cellular phenotypes. However, it is unclear concerning the clinical significance of LATS1 and the regulatory mechanisms of 17-Allylamino-17- demethoxygeldanamycin (17-AAG) in lung adenocarcinoma (LAC). The aim of the present study was to investigate the correlation of LATS1 and yes-associated protein (YAP) expression with clinicopathological characteristics in LAC patients, and the effects of 17-AAG on biological behaviours of LAC cells. Subcutaneous LAC tumour models were further established to observe the tumour growth in nude mice. The results showed that the positive expression of LATS1 was significantly lowered (26.7% versus 68.0%, P AAG inhibited proliferation and invasion, and induced cell apoptosis and cycle arrest in LAC cells together with increased expression of E-cadherin and p-LATS1, and decreased expression of YAP and connective tissue growth factor. Tumour volumes and weight were much smaller in 17-AAG-treated groups than those in untreated group (P AAG suppresses growth and invasion of LAC cells via regulation of the LATS1/YAP pathway in vitro and in vivo, suggesting that we may provide a promising therapeutic strategy for the treatment of human LAC. PMID:25712415

Novel scintillators and silicon photomultipliers for nuclear physics and applications

International Nuclear Information System (INIS)

Jenkins, David

2015-01-01

Until comparatively recently, scintillator detectors were seen as an old-fashioned tool of nuclear physics with more attention being given to areas such as gamma-ray tracking using high-purity germanium detectors. Next-generation scintillator detectors, such as lanthanum bromide, which were developed for the demands of space science and gamma- ray telescopes, are found to have strong applicability to low energy nuclear physics. Their excellent timing resolution makes them very suitable for fast timing measurements and their much improved energy resolution compared to conventional scintillators promises to open up new avenues in nuclear physics research which were presently hard to access. Such 'medium-resolution' spectroscopy has broad interest across several areas of contemporary interest such as the study of nuclear giant resonances. In addition to the connections to space science, it is striking that the demands of contemporary medical imaging have strong overlap with those of experimental nuclear physics. An example is the interest in PET-MRI combined imaging which requires putting scintillator detectors in a high magnetic field environment. This has led to strong advances in the area of silicon photomultipliers, a solid-state replacement for photomultiplier tubes, which are insensitive to magnetic fields. Broad application to nuclear physics of this technology may be foreseen. (paper)

Roles of the Yap1 transcription factor and antioxidants in Saccharomyces cerevisiae's tolerance to furfural and 5-hydroxymethylfurfural, which function as thiol-reactive electrophiles generating oxidative stress.

Science.gov (United States)

Kim, Daehee; Hahn, Ji-Sook

2013-08-01

Development of the tolerance of Saccharomyces cerevisiae strains to furfural and 5-hydroxymethylfurfural (HMF) is an important issue for cellulosic ethanol production. Although furfural and HMF are known to induce oxidative stress, the underlying mechanisms are largely unknown. In this study, we show that both furfural and HMF act as thiol-reactive electrophiles, thus directly activating the Yap1 transcription factor via the H2O2-independent pathway, depleting cellular glutathione (GSH) levels, and accumulating reactive oxygen species in Saccharomyces cerevisiae. However, furfural showed higher reactivity than did HMF toward GSH in vitro and in vivo. In line with such toxic mechanisms, overexpression of YAP1(C620F), a constitutively active mutant of YAP1, and Yap1 target genes encoding catalases (CTA1 and CTT1) increased tolerance to furfural and HMF. However, increasing GSH levels by overexpression of genes for GSH biosynthesis (GSH1 and GLR1) or by the exogenous addition of GSH to the culture medium enhanced tolerance to furfural but not to HMF.

First characterization of the SPADnet sensor: a digital silicon photomultiplier for PET applications

Science.gov (United States)

Gros-Daillon, E.; Maingault, L.; André, L.; Reboud, V.; Verger, L.; Charbon, E.; Bruschini, C.; Veerappan, C.; Stoppa, D.; Massari, N.; Perenzoni, M.; Braga, L. H. C.; Gasparini, L.; Henderson, R. K.; Walker, R.; East, S.; Grant, L.; Jatekos, B.; Lorincz, E.; Ujhelyi, F.; Erdei, G.; Major, P.; Papp, Z.; Nemeth, G.

2013-12-01

Silicon Photomultipliers have the ability to replace photomultiplier tubes when used as light sensors in scintillation gamma-ray detectors. Their timing properties, compactness, and magnetic field compatibility make them interesting for use in Time-of-Flight Magnetic Resonance Imaging compatible Positron Emission Tomography. In this paper, we present a new fully digital Single Photon Avalanche Diode (SPAD) based detector fabricated in CMOS image sensor technology. It contains 16x8 pixels with a pitch of 610x571.2 μm2. The Dark Count Rate and the Photon Detection Probability of each SPAD has been measured and the homogeneity of these parameters in the entire 92000 SPAD array is shown. The sensor has been optically coupled to a single LYSO needle and a LYSO array. The scintillator crystal was irradiated with several gamma sources and the resulting images and energy spectra are presented.

TRitium Activity Measurements with a PhotomultipliEr in Liquids–The TRAMPEL experiment

International Nuclear Information System (INIS)

Priester, Florian; Klein, Manuel

2016-01-01

Highlights: • We have set up a new test device for measuring of tritiated water samples. • The device is very compact and easy and reliable in operation. • Easy integration in flow-through systems is possible. • The device has been operated at Tritium Laboratory Karlsruhe for several months. • The lower detection limit has been improved with regard to predecessors experiments. - Abstract: A common technique for the determination of the activity of tritiated water (HTO) is liquid scintillation counting (LSC). This implies sample taking, sample preparation and radioactive waste processing afterwards. When handling highly tritiated water special care has to be taken because of possible harmfulness of the sample. Furthermore, LSC devices are mostly large, heavy and expensive. The TRAMPEL experiment aims at measuring the activity of tritiated water in-line without sample taking. The device is intended to be easy to use and operate, quite inexpensive and compact. The measurement principle is based on electrons from β-decay which induce light in commercially available scintillation fibres. The light is detected by a small photomultiplier tube (PMT). A proof-of-principle was set up for static measurements using standard stainless steel parts. The complete device has a volume of less than 0.5 l.

TRitium Activity Measurements with a PhotomultipliEr in Liquids–The TRAMPEL experiment

Energy Technology Data Exchange (ETDEWEB)

Priester, Florian, E-mail: florian.priester@kit.edu; Klein, Manuel

2016-11-01

Highlights: • We have set up a new test device for measuring of tritiated water samples. • The device is very compact and easy and reliable in operation. • Easy integration in flow-through systems is possible. • The device has been operated at Tritium Laboratory Karlsruhe for several months. • The lower detection limit has been improved with regard to predecessors experiments. - Abstract: A common technique for the determination of the activity of tritiated water (HTO) is liquid scintillation counting (LSC). This implies sample taking, sample preparation and radioactive waste processing afterwards. When handling highly tritiated water special care has to be taken because of possible harmfulness of the sample. Furthermore, LSC devices are mostly large, heavy and expensive. The TRAMPEL experiment aims at measuring the activity of tritiated water in-line without sample taking. The device is intended to be easy to use and operate, quite inexpensive and compact. The measurement principle is based on electrons from β-decay which induce light in commercially available scintillation fibres. The light is detected by a small photomultiplier tube (PMT). A proof-of-principle was set up for static measurements using standard stainless steel parts. The complete device has a volume of less than 0.5 l.

LHCb: Characterisation and magnetic field properties of Multianode Photomultiplier tubes for the use in LHCb Upgrade RICH detectors

CERN Multimedia

Eisenhardt, S; Morris, A; Needham, M; Neill, J

2013-01-01

A key feature of the LHCb upgrade, scheduled for 2019, is to remove the first level trigger and its data reduction from 40MHz to 1MHz, which is implemented in the on-detector readout electronics. The consequence for the LHCb Ring Imaging Cherenkov (RICH) detectors is that the Hybrid Photon Detectors need to be replaced as the readout chip is embedded in the tubes. Baseline for replacement are Multianode Photomultiplier tubes (MaPMT) and new readout electronics. Here we report about characterisation studies of the model Hamamatsu R11265 in the effort to qualify them for use in the LHCb RICH upgrade. Comparisons to the known model R7600 are also made. Two types of readout electronics are used. Most measurements to characterise the properties of the MaPMTs are taken with a VME based reference readout, using a x100 linear amplification and the CAEN V792 12-bit charge integrating digitiser. This allows to derive the signal properties from fits to the single photon spectra. In addition a prototype readout using the...

Comparative study of new 130mm diameter fast photomultipliers for neutron detectors

International Nuclear Information System (INIS)

Moszynski, M.; Costa, G.J.; Guillaume, G.; Heusch, B.; Huck, A.; Mouatassim, S.

1991-01-01

The present paper is a summary of the test measurements carried out using new 130 mm diameter fast photomultiplier tubes manufactured by Philips (France), EMI (England) and Hamamatsu (Japan), along with a comparison to the results obtained with the well known XP 2041 Philips model. These tubes will be used in large size neutron detectors

Window Stories

DEFF Research Database (Denmark)

Hauge, Bettina

This research project has investigated 17 households in Germany (cities and rural areas). The main aim was to learn about the significance of the window to these people: What they think of their windows, how, when and why they use them in their everyday life, if they have a favorite window and wh...

Windows 10 simplified

CERN Document Server

McFedries, Paul

2015-01-01

Learn Windows 10 quickly and painlessly with this beginner's guide Windows 10 Simplified is your absolute beginner's guide to the ins and outs of Windows. Fully updated to cover Windows 10, this highly visual guide covers all the new features in addition to the basics, giving you a one-stop resource for complete Windows 10 mastery. Every page features step-by-step screen shots and plain-English instructions that walk you through everything you need to know, no matter how new you are to Windows. You'll master the basics as you learn how to navigate the user interface, work with files, create

Windows and doors

Energy Technology Data Exchange (ETDEWEB)

1988-01-01

A complete manual is presented on windows and doors for the housing contractor. In order to understand the role of windows and doors in a house's energy performance, an introduction explains the house as a system of components that can have effects on each other. Further chapters explain in detail the parts of a window, window types and RSI values; window servicing and repair; window replacement; parts of a door, door types and RSI values; door service and repair, including weatherstripping; door replacement; and how to ensure quality, service, and customer satisfaction. A glossary of terms is included. 61 figs., 3 tabs.

Cherenkov luminescence measurements with digital silicon photomultipliers: a feasibility study

Energy Technology Data Exchange (ETDEWEB)

Ciarrocchi, Esther; Belcari, Nicola; Guerra, Alberto Del [Department of Physics, University of Pisa, Pisa (Italy); INFN, section of Pisa, Pisa (Italy); Cherry, Simon R. [Department of Biomedical Engineering, University of California, Davis, CA (United States); Lehnert, Adrienne; Hunter, William C. J.; McDougald, Wendy; Miyaoka, Robert S.; Kinahan, Paul E. [Department of Radiology, University of Washington, Seattle, WA (United States)

2015-11-16

A feasibility study was done to assess the capability of digital silicon photomultipliers to measure the Cherenkov luminescence emitted by a β source. Cherenkov luminescence imaging (CLI) is possible with a charge coupled device (CCD) based technology, but a stand-alone technique for quantitative activity measurements based on Cherenkov luminescence has not yet been developed. Silicon photomultipliers (SiPMs) are photon counting devices with a fast impulse response and can potentially be used to quantify β-emitting radiotracer distributions by CLI. In this study, a Philips digital photon counting (PDPC) silicon photomultiplier detector was evaluated for measuring Cherenkov luminescence. The PDPC detector is a matrix of avalanche photodiodes, which were read one at a time in a dark count map (DCM) measurement mode (much like a CCD). This reduces the device active area but allows the information from a single avalanche photodiode to be preserved, which is not possible with analog SiPMs. An algorithm to reject the noisiest photodiodes and to correct the measured count rate for the dark current was developed. The results show that, in DCM mode and at (10–13) °C, the PDPC has a dynamic response to different levels of Cherenkov luminescence emitted by a β source and transmitted through an opaque medium. This suggests the potential for this approach to provide quantitative activity measurements. Interestingly, the potential use of the PDPC in DCM mode for direct imaging of Cherenkov luminescence, as a opposed to a scalar measurement device, was also apparent. We showed that a PDPC tile in DCM mode is able to detect and image a β source through its Cherenkov radiation emission. The detector’s dynamic response to different levels of radiation suggests its potential quantitative capabilities, and the DCM mode allows imaging with a better spatial resolution than the conventional event-triggered mode. Finally, the same acquisition procedure and data processing could

Cherenkov luminescence measurements with digital silicon photomultipliers: a feasibility study

International Nuclear Information System (INIS)

Ciarrocchi, Esther; Belcari, Nicola; Guerra, Alberto Del; Cherry, Simon R.; Lehnert, Adrienne; Hunter, William C. J.; McDougald, Wendy; Miyaoka, Robert S.; Kinahan, Paul E.

2015-01-01

A feasibility study was done to assess the capability of digital silicon photomultipliers to measure the Cherenkov luminescence emitted by a β source. Cherenkov luminescence imaging (CLI) is possible with a charge coupled device (CCD) based technology, but a stand-alone technique for quantitative activity measurements based on Cherenkov luminescence has not yet been developed. Silicon photomultipliers (SiPMs) are photon counting devices with a fast impulse response and can potentially be used to quantify β-emitting radiotracer distributions by CLI. In this study, a Philips digital photon counting (PDPC) silicon photomultiplier detector was evaluated for measuring Cherenkov luminescence. The PDPC detector is a matrix of avalanche photodiodes, which were read one at a time in a dark count map (DCM) measurement mode (much like a CCD). This reduces the device active area but allows the information from a single avalanche photodiode to be preserved, which is not possible with analog SiPMs. An algorithm to reject the noisiest photodiodes and to correct the measured count rate for the dark current was developed. The results show that, in DCM mode and at (10–13) °C, the PDPC has a dynamic response to different levels of Cherenkov luminescence emitted by a β source and transmitted through an opaque medium. This suggests the potential for this approach to provide quantitative activity measurements. Interestingly, the potential use of the PDPC in DCM mode for direct imaging of Cherenkov luminescence, as a opposed to a scalar measurement device, was also apparent. We showed that a PDPC tile in DCM mode is able to detect and image a β source through its Cherenkov radiation emission. The detector’s dynamic response to different levels of radiation suggests its potential quantitative capabilities, and the DCM mode allows imaging with a better spatial resolution than the conventional event-triggered mode. Finally, the same acquisition procedure and data processing could

Short and long range gain monitoring of photomultipliers by means of a light pulser and an optical fibers bunch

International Nuclear Information System (INIS)

Besson, P.

1989-01-01

The gain monitoring of 8 XP3462 photomultipliers has been studied during a period of 3 months with a spark gap as a light pulser, an optical fibres bunch and 3 reference detectors. One of the reference PM is monitored thanks to a cristal of NaI irradiated by an 241 Am radioactive source, whereas the photodiode and its associated electronic is monitored thanks to a 57 Co source directly coupled to the junction. Two experimental methods have been tested. First the short term method consists in estimating several means of charge distributions and supposes the stability of different optical parameters like quantum efficiency or photoelectrons collection efficiency. The long term method consists in estimating several variances of charge distributions and supposes the validity, at first order, of photomultipliers' equations. In spite of unpropitious experimental conditions (tension switch off, no climatisation..), our results indicate that the short term method provides a precision of about 0.5% for the relative gain value but only during a short period which has been of 20 days. The long term method provides a precision of about 1.5% but is remained available during the 3 months of our experiment. This study has been developed for the new Neutrino oscillation program taking place near the Bugey nuclear plant and using 600 photomultipliers. The conclusions mentioned above are nevertheless valid for any particle detectors using photomultipliers [fr

Fast readout of scintillating fibres using position-sensitive photomultipliers

International Nuclear Information System (INIS)

Agoritsas, V.; Akchurin, N.; Bergdolt, A.M.; Bing, O.; Bravar, A.; Ditta, J.; Dufournaud, J.; Dyachenko, V.A.; Giacomich, R.; Gorin, A.M.; Kuroda, K.; Magaudda, D.; Newsom, C.; Okada, K.; Onel, Y.; Penzo, A.; Rakhmatov, V.Ye.; Rykalin, V.I.; Salvato, G.; Savin, A.A.; Schiavon, P.; Sillou, D.; Solovyov, Yu.A.; Takeutchi, F.; Tareb-Reyes, M.; Vasilchenko, V.G.; Yoshida, T.; Zaychenko, A.A.

1994-01-01

Major progress has recently been achieved in the fast readout of scintillating fibres using position-sensitive photomultipliers (PSPMs). Experimental results obtained with commercially available PSPMs already show a space resolution better than 200 μm, a time resolution of about 1.5 ns with a detection efficiency higher than 90%, and the possibility of separating double hits with a minimum distance of ∼3 mm. An upgrade of PSPMs based on new dynode structures is also in progress. Results obtained with one new PSPM prototype in a magnetic field are also presented. (orig.)

Photomultiplier pulse Read Out system for the preshower detector of the LHCb experiment

CERN Document Server

Ajaltouni, Ziad J; Cornat, R; Deschamps, O; Lecoq, J; Monteil, S; Perret, P

2003-01-01

The second generation experiment for CP violation studies in B decays, LHCb, is a 20-m-long single-arm spectrometer to be installed on the future Large Hadron Collider at CERN. For its precision measurement purpose, it combines precise vertex location and particle identification, in addition to a performance trigger system able to cope with high flux. The first level of trigger is mainly based on the fast response of the calorimetric subsystem. Of major importance is the 6000 channels preshower detector that aims to validate the electromagnetic nature of calorimetric showers. It consists of two- radiation-length lead sheet in front of a scintillator plane. Scintillator signals are extracted from plastic cells using wavelength-shifting fibres coupled to multi-anode photomultiplier tubes. The preshower Read Out system has to cope with fluctuating photomultiplier pulses caused by small amounts of photoelectrons, in addition to strong constraints imposed by the 40 MHz LHC bunch- crossing frequency. A special Read...

Full-scale testing of infilled steel frames with precast concrete panels provided with a window opening

NARCIS (Netherlands)

Teeuwen, P.A; Kleinman, C.S.; Snijder, H.H.; Hofmeyer, H.

2008-01-01

As an alternative to conventional structures for tall buildings, a hybrid lateral load resisting building system has been designed, enabling the assembly of tall buildings directly from truck. It consists of steel frames with discretely connected precast concrete infill panels provided with a window

An Educational Kit Based On a Modular Silicon Photomultiplier System

International Nuclear Information System (INIS)

Caccia, Massimo; Chmill, Valery; Ebolese, Amedeo; Martemyanov, Alexander; Risigo, Fabio; Santoro, Romualdo; Locatelli, Marco; Pieracci, Maura; Tintori, Carlo

2013-06-01

Silicon Photo-Multipliers (SiPM) are state of the art light detectors with unprecedented single photon sensitivity and photon number resolving capability, representing a breakthrough in several fundamental and applied Science domains. An educational experiment based on a SiPM set-up is proposed in this article, guiding the student towards a comprehensive knowledge of this sensor technology while experiencing the quantum nature of light and exploring the statistical properties of the light pulses emitted by a LED. (authors)

The impact of economic growth on environmental efficiency of the electricity sector: A hybrid window DEA methodology for the USA.

Science.gov (United States)

Halkos, George E; Polemis, Michael L

2018-04-01

This paper estimates the efficiency of the power generation sector in the USA by using Window Data Envelopment Analysis (W-DEA). We integrate radial and non-radial efficiency measurements in DEA using the hybrid measure while we extend the proposed model by considering good and undesirable outputs as separable and non separable. Then in the second stage, we perform parametric and non-parametric econometric techniques in order to model the relationship between the calculated environmental efficiencies and economic growth in attaining sustainability. Our empirical findings indicate a stable N-shape relationship between environmental efficiency and regional economic growth in the case of global and total pollutants but an inverted N-shape in the case of local pollutants. This implies that attention is required when considering local and global pollutants and the extracted environmental efficiency scores. A clear message to policy makers and government officials is that climate change which calls for economic, environmental and social concern should be analyzed according to its dispersion and regional dimension. Copyright © 2018 Elsevier Ltd. All rights reserved.

MS Windows domēna darbstacijas migrācijas iespējas no MS Windows XP uz MS Windows 7.

OpenAIRE

Zariņš, Valdis

2009-01-01

Kvalifikācijas darbā tiek aprakstītas MS Windows domēna darbstacijas migrācijas iespējas no MS Windows XP uz MS Windows 7, kā servera operētājsistēmas izmantojot tādus Microsoft produktus, kā Microsoft Windows Server 2003 un Microsoft Windows Server 2008. Kvalifikācijas darba teorētiskaja daļā tiek apskatīti Microsoft Windows 7 priekšrocības un uzlabojumus gan no darbstacijas lietotāja , gan no darbstacijas administratora puses. Ir aprakstītas Microsoft Windows Server 2008 jauninājumu ie...

Modeling crosstalk in silicon photomultipliers

International Nuclear Information System (INIS)

Gallego, L; Rosado, J; Blanco, F; Arqueros, F

2013-01-01

Optical crosstalk seriously limits the photon-counting resolution of silicon photomultipliers. In this work, realistic analytical models to describe the crosstalk effects on the response of these photodetectors are presented and compared with experimental data. The proposed models are based on the hypothesis that each pixel of the array has a finite number of available neighboring pixels to excite via crosstalk. Dead-time effects and geometrical aspects of the propagation of crosstalk between neighbors are taken into account in the models for different neighborhood configurations. Simple expressions to account for crosstalk effects on the pulse-height spectrum as well as to evaluate the excess noise factor due to crosstalk are also given. Dedicated measurements were carried out under both dark-count conditions and pulsed illumination. Moreover, the influence of afterpulsing on the measured pulse-height spectrum was studied, and a measurement of the recovery time of pixels was reported. High-resolution pulse-height spectra were obtained by means of a detailed waveform analysis, and the results have been used to validate our crosstalk models.

Characterization of the 10-stages R5900 Hamamatsu photomultipliers for the hadronic ATLAS calorimeter

International Nuclear Information System (INIS)

Montarou, G.; Bouhemaid, N.; Grenier, Ph.; Crouau, M.; Muanza, G.S.; Poirot, S.; Vazeille, F.; Gil Botella, I.; Hoz, S.G. de la

1997-01-01

The measurements carried out, at Clermont on the R5900 Hamamatsu photomultipliers for the ATLAS hadronic calorimeter are summarised. The TILECAL specifications are given. Amplification measurements, dark current measurements, linearity, magnetic sensitivity and the voltage divider optimisation are presented. (K.A.)

17-AAG suppresses growth and invasion of lung adenocarcinoma cells via regulation of the LATS1/YAP pathway.

Science.gov (United States)

Ye, Xiang-Yun; Luo, Qing-Quan; Xu, Yun-Hua; Tang, Nai-Wang; Niu, Xiao-Min; Li, Zi-Ming; Shen, Sheng-Ping; Lu, Shun; Chen, Zhi-Wei

2015-03-01

The large tumour suppressor 1 (LATS1) signalling network has been proved to be an essential regulator within the cell, participating in multiple cellular phenotypes. However, it is unclear concerning the clinical significance of LATS1 and the regulatory mechanisms of 17-Allylamino-17- demethoxygeldanamycin (17-AAG) in lung adenocarcinoma (LAC). The aim of the present study was to investigate the correlation of LATS1 and yes-associated protein (YAP) expression with clinicopathological characteristics in LAC patients, and the effects of 17-AAG on biological behaviours of LAC cells. Subcutaneous LAC tumour models were further established to observe the tumour growth in nude mice. The results showed that the positive expression of LATS1 was significantly lowered (26.7% versus 68.0%, P AAG inhibited proliferation and invasion, and induced cell apoptosis and cycle arrest in LAC cells together with increased expression of E-cadherin and p-LATS1, and decreased expression of YAP and connective tissue growth factor. Tumour volumes and weight were much smaller in 17-AAG-treated groups than those in untreated group (P AAG suppresses growth and invasion of LAC cells via regulation of the LATS1/YAP pathway in vitro and in vivo, suggesting that we may provide a promising therapeutic strategy for the treatment of human LAC. © 2015 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.

A Dual-Responsive Nanocomposite toward Climate-Adaptable Solar Modulation for Energy-Saving Smart Windows.

Science.gov (United States)

Lee, Heng Yeong; Cai, Yufeng; Bi, Shuguang; Liang, Yen Nan; Song, Yujie; Hu, Xiao Matthew

2017-02-22

In this work, a novel fully autonomous photothermotropic material made by hybridization of the poly(N-isopropylacrylamide) (PNIPAM) hydrogel and antimony-tin oxide (ATO) is presented. In this photothermotropic system, the near-infrared (NIR)-absorbing ATO acts as nanoheater to induce the optical switching of the hydrogel. Such a new passive smart window is characterized by excellent NIR shielding, a photothermally activated switching mechanism, enhanced response speed, and solar modulation ability. Systems with 0, 5, 10, and 15 atom % Sb-doped ATO in PNIPAM were investigated, and it was found that a PNIPAM/ATO nanocomposite is able to be photothermally activated. The 10 atom % Sb-doped PNIPAM/ATO exhibits the best response speed and solar modulation ability. Different film thicknesses and ATO contents will affect the response rate and solar modulation ability. Structural stability tests at 15 cycles under continuous exposure to solar irradiation at 1 sun intensity demonstrated the performance stability of such a photothermotropic system. We conclude that such a novel photothermotropic hybrid can be used as a new generation of autonomous passive smart windows for climate-adaptable solar modulation.

Resources | Efficient Windows Collaborative

Science.gov (United States)

Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

Links | Efficient Windows Collaborative

Science.gov (United States)

Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

Efficient Windows Collaborative | Home

Science.gov (United States)

Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

FAQ | Efficient Windows Collaborative

Science.gov (United States)

Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

Glossary | Efficient Windows Collaborative

Science.gov (United States)

Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

Türkiye’de süs bitkileri sektörünün üretim ve yapısal sorunları ve öneriler

OpenAIRE

ONAY, Hatice Aslı

2008-01-01

ÖZET:

Bu tez çalışması Türkiye’de süs bitkileri sektörünün üretim ve yapısal sorunlarını analiz ederek bunlara yapıcı ve sürdürülebilir çözümler üretmek amacıyla yapılmıştır. Bunun için öncelikle sektörün ülkemizdeki mevcut durumu ortaya konulmaya çalışılmıştır. Mevcut durumu ortaya koymak için ise sektörün üretim, ithalat ve ihracat verilerinden yararlanılmıştır. Birçok kurum ve kuruluşlardan edinilen bu veriler ışığında sekt...

Windows® Internals

CERN Document Server

Russinovich, Mark E; Ionescu, Alex

2009-01-01

See how the core components of the Windows operating system work behind the scenes-guided by a team of internationally renowned internals experts. Fully updated for Windows Server 2008 and Windows Vista, this classic guide delivers key architectural insights on system design, debugging, performance, and support-along with hands-on experiments to experience Windows internal behavior firsthand.Delve inside Windows architecture and internals:Understand how the core system and management mechanisms work-from the object manager to services to the registryExplore internal system data structures usin

Silicon Photo-Multiplier Radiation Hardness Tests with a White Neutron Beam

International Nuclear Information System (INIS)

Montanari, A.; Tosi, N.; Pietropaolo, A.; Andreotti, M.; Baldini, W.; Calabrese, R.; Cibinetto, G.; Luppi, E.; Cotta Ramusino, A.; Malaguti, R.; Santoro, V.; Tellarini, G.; Tomassetti, L.; De Donato, C.; Reali, E.

2013-06-01

We report radiation hardness tests performed, with a white neutron beam, at the Geel Electron Linear Accelerator in Belgium on silicon Photo-Multipliers. These are semiconductor photon detectors made of a square matrix of Geiger-Mode Avalanche photo-diodes on a silicon substrate. Several samples from different manufacturers have been irradiated integrating up to about 6.2 x 10 9 1-MeV-equivalent neutrons per cm 2 . (authors)

Digital position sensitive discrimination for 2-dimensional scintillation detectors

International Nuclear Information System (INIS)

Engels, R.; Reinartz, R.; Reinhart, P.

1996-01-01

The energy sensitivity of a two-dimensional scintillation gamma detector based on position sensitive photomultipliers has been minimized by a digital differential discrimination unit. Since the photomultiplier gain is position-dependent by 50%, a discrimination unit has been developed where digital upper and lower discrimination levels are set due to the position-dependent photomultiplier gain obtained from calibration measurements. Depending on the spatial resolution there can be up to 65.536 position-sensitive discriminator levels defining energy windows. By this method, narrow discriminator windows can be used for reducing the low and high energy quanta without effecting the sensitivity of the detector. The new discrimination method, its performance and test measurements with gamma rays will be described. Furthermore experimental results are presented

GEM-based gaseous photomultipliers for UV and visible photon imaging

International Nuclear Information System (INIS)

Moermann, D.; Balcerzyk, M.; Breskin, A.; Chechik, R.; Singh, B.K.; Buzulutskov, A.

2003-01-01

We present the current status of our research on GEM-based gaseous photomultipliers. Detectors combining multi-GEM electron multipliers with semi-transparent and reflective photocathodes are discussed. We present recent progress in extending the sensitivity of these detectors into the visible range. We demonstrate the long-term stability of an argon-sealed bi-alkali photo-diode and provide preliminary results of a gas-sealed Kapton-GEM detector with a bi-alkali photocathode. The problem of ion-induced secondary electron emission is addressed

Silicon photomultiplier's gain stabilization by bias correction for compensation of the temperature fluctuations

International Nuclear Information System (INIS)

Dorosz, P.; Baszczyk, M.; Glab, S.; Kucewicz, W.; Mik, L.; Sapor, M.

2013-01-01

Gain of the silicon photomultiplier is strongly dependent on the value of bias voltage and temperature. This paper proposes a method for gain stabilization just by compensation of temperature fluctuations by bias correction. It has been confirmed that this approach gives good results and the gain can be kept very stable

Study of a photomultiplier for the measurement of low light flows by photon counting

International Nuclear Information System (INIS)

Haye, Kleber

1964-01-01

After a recall of the history of the discovery and use of the photoemission effect, a presentation of the main characteristics of photomultipliers, a discussion of performance and weaknesses of electron multiplier-based cells, this research thesis addresses the study of low light flows. The author tried to determine whether it was possible, at ambient temperature, to reduce the influence of the thermoelectric effect. In order to do so, he made a detailed study of the amplitude spectrum of pulses of photoelectric origin. In order to analyse the influence of temperature of photomultiplier characteristics, he studied, with respect to temperature, the variation of the counting rate corresponding to darkness, the variation of pulse amplitude spectrum, and relative variations of the quantum efficiency for various wavelengths. In parallel with the study by counting, a study has been performed by using the well known mean current measurement [fr

Radiation Effects of n-type, Low Resistivity, Spiral Silicon Drift Detector Hybrid Systems

International Nuclear Information System (INIS)

Chen, W.; De Geronimo, G.; Carini, G.A.; Gaskin, J.A.; Keister, J.W.; Li, S.; Li, Z.; Ramsey, B.D.; Siddons, D.P.; Smith, G.C.; Verbitskaya, E.

2011-01-01

We have developed a new thin-window, n-type, low-resistivity, spiral silicon drift detector (SDD) array - to be used as an extraterrestrial X-ray spectrometer (in varying environments) for NASA. To achieve low-energy response, a thin SDD entrance window was produced using a previously developed method. These thin-window devices were also produced on lower resistivity, thinner, n-type, silicon material, effectively ensuring their radiation hardness in anticipation of operation in potentially harsh radiation environments (such as found around the Jupiter system). Using the Indiana University Cyclotron Facility beam line RERS1, we irradiated a set of suitable diodes up to 5 Mrad and the latest iteration of our ASICs up to 12 Mrad. Then we irradiated two hybrid detectors consisting of newly, such-produced in-house (BNL) SDD chips bonded with ASICs with doses of 0.25 Mrad and 1 Mrad. Also we irradiated another hybrid detector consisting of previously produced (by KETEK) on n-type, high-resistivity SDD chip bonded with BNL's ASICs with a dose of 1 Mrad. The measurement results of radiated diodes (up to 5 Mrad), ASICs (up to 12 Mrad) and hybrid detectors (up to 1 Mrad) are presented here.

Development of high performance readout ASICs for silicon photomultipliers (SiPMs)

International Nuclear Information System (INIS)

Shen, Wei

2012-01-01

Silicon Photomultipliers (SiPMs) are novel kind of solid state photon detectors with extremely high photon detection resolution. They are composed of hundreds or thousands of avalanche photon diode pixels connected in parallel. These avalanche photon diodes are operated in Geiger Mode. SiPMs have the same magnitude of multiplication gain compared to the conventional photomultipliers (PMTs). Moreover, they have a lot of advantages such as compactness, relatively low bias voltage and magnetic field immunity etc. Special readout electronics are required to preserve the high performance of the detector. KLauS and STiC are two CMOS ASIC chips designed in particular for SiPMs. KLauS is used for SiPM charge readout applications. Since SiPMs have a much larger detector capacitance compared to other solid state photon detectors such as PIN diodes and APDs, a few special techniques are used inside the chip to make sure a descent signal to noise ratio for pixel charge signal can be obtained. STiC is a chip dedicated to SiPM time-of-flight applications. High bandwidth and low jitter design schemes are mandatory for such applications where time jitter less than tens of picoseconds is required. Design schemes and error analysis as well as measurement results are presented in the thesis.

A method to stabilise the performance of negatively fed KM3NeT photomultipliers

NARCIS (Netherlands)

Adrián-Martínez, S.; Ageron, M.; Aiello, S.; Albert, A.; Ameli, F.; Anassontzis, E.G.; Andre, M.; Androulakis, G.; Anghinolfi, M.; Anton, G.; Ardid, M.; Avgitas, T.; Barbarino, G.; Barbarito, E.; Baret, B.; Barrios-Martí, J.; Belias, A.; Berbee, E.; Berg, A. van den; Bertin, V.; Beurthey, S.; Beveren, V. van; Beverini, N.; Biagi, S.; Biagioni, A.; Billault, M.; Bondì, M.; Bormuth, R.; Bouhadef, B.; Bourlis, G.; Bourret, S.; Boutonnet, C.; Bouwhuis, M.; Bozza, C.; Bruijn, R.; Brunner, J.; Buis, E.J.; Buompane, R.; Busto, J.; Cacopardo, G.; Caillat, L.; Calamai, M.; Calvo, D.; Capone, A.; Caramete, L.; Cecchini, S.; Celli, S.; Champion, C.; Cherubini, S.; Chiarella, V.; Chiarelli, L.; Chiarusi, T.; Circella, M.; Classen, L.; Cobas, D.; Cocimano, R.; Coelho, J.A.B.; Coleiro, A.; Colonges, S.; Coniglione, R.; Cordelli, M.; Cosquer, A.; Coyle, P.; Creusot, A.; Cuttone, G.; D'Amato, C.; D'Amico, A.; D'Onofrio, A.; De Bonis, G.; De Sio, C.; Di Capua, F.; Di Palma, I.; Distefano, C.; Donzaud, C.; Dornic, D.; Dorosti-Hasankiadeh, Q.; Drakopoulou, E.; Drouhin, D.; Durocher, M.; Eberl, T.; Eichie, S.; Van Eijk, D.; El Bojaddaini, I.; Elsaesser, D.; Enzenhöfer, A.; Favaro, M.; Fermani, P.; Ferrara, G.; Frascadore, G.; Furini, M.; Fusco, L.A.; Gal, T.; Galatà, S.; Garufi, F.; Gay, P.; Gebyehu, M.; Giacomini, F.; Gialanella, L.; Giordano, V.; Gizani, N.; Gracia, R.; Graf, K.; Grégoire, T.; Grella, G.; Grmek, A.; Guerzoni, M.; Habel, R.; Hallmann, S.; Haren, H. van; Harissopulos, S.; Heid, T.; Heijboer, A.; Heine, E.; Henry, S.; Hernández-Rey, J.J.; Hevinga, M.; Hofestädt, J.; Hugon, C.M.F.; Illuminati, G.; James, C.W.; Jansweijer, P.; Jongen, M.; Jong, M. de; Kadler, M.; Kalekin, O.; Kappes, A.; Katz, U.F.; Keller, P.; Kieft, G.; Kießling, D.; Koffeman, E.N.; Kooijman, P.; Kouchner, A.; Kreter, M.; Kulikovskiy, V.; Lahmann, R.; Lamare, P.; Leisos, A.; Leonora, E.; Clark, M.L.; Liolios, A.; Alvarez, C.D.L.; Lo Presti, D.; Löhner, H.; Lonardo, A.; Lotze, M.; Loucatos, S.; Maccioni, E.; Mannheim, K.; Manzali, M.; Margiotta, A.; Margotti, A.; Marinelli, A.; Mariš, O.; Markou, C.; Martínez-Mora, J.A.; Martini, A.; Marzaioli, F.; Mele, R.; Melis, K.W.; Michael, T.; Migliozzi, P.; Migneco, E.; Mijakowski, P.; Miraglia, A.; Mollo, C.M.; Mongelli, M.; Morganti, M.; Moussa, A.; Musico, P.; Musumeci, M.; Nicolau, C.A.; Olcina, I.; Olivetto, C.; Orlando, A.; Orzelli, A.; Pancaldi, G.; Paolucci, A.; Papaikonomou, A.; Papaleo, R.; Pǎvǎlaš, G.E.; Peek, H.; Pellegrini, G.; Pellegrino, C.; Perrina, C.; Pfutzner, M.; Piattelli, P.; Pikounis, K.; Poma, G.E.; Popa, V.; Pradier, T.; Pratolongo, F.; Pühlhofer, G.; Pulvirenti, S.; Quinn, L.; Racca, C.; Raffaelli, F.; Randazzo, N.; Real, D.; Resvanis, L.; Reubelt, J.; Riccobene, G.; Rossi, C.; Rovelli, A.; Saldaña, M.; Salvadori, I.; Samtleben, D.F.E.; Sánchez García, A.; Sánchez Losa, A.; Sanguineti, M.; Santangelo, A.; Santonocito, D.; Sapienza, P.; Schimmel, F.; Schmelling, J.; Schnabel, J.; Sciacca, V.; Sedita, M.; Seitz, T.; Sgura, I.; Simeone, F.; Sipala, V.; Spisso, B.; Spurio, M.; Stavropoulos, G.; Steijger, J.; Stellacci, S.M.; Stransky, D.; Taiuti, M.; Tayalati, Y.; Terrasi, F.; Tézier, D.; Theraube, S.; Timmer, P.; Tönnis, C.; Trasatti, L.; Travaglini, R.; Trovato, A.; Tsirigotis, A.; Tzamarias, S.; Tzamariudaki, E.; Vallage, B.; Van Elewyck, V.; Vermeulen, J.; Versari, F.; Vicini, P.; Viola, S.; Vivolo, D.; Volkert, M.; Wiggers, L.; Wilms, J.; Wolf, E. de; Zachariadou, K.; Zani, S.; Zornoza, J.D.; Zúñiga, J.

2016-01-01

The KM3NeT research infrastructure, currently under construction in the Mediterranean Sea, will host neutrino telescopes for the identification of neutrino sources in the Universe and for studies of the neutrino mass hierarchy. These telescopes will house hundreds of thousands of photomultiplier

Modeling the low-light response of photomultiplier tubes

Science.gov (United States)

Maxwell, Patrick; Niculescu, Ioana

2017-09-01

A number of crucial experiments exploring the intricate tomography of protons and neutrons will be carried out in Hall A at Jefferson Lab using the SuperBigBite Spectrometer (SBS), a large acceptance magnetic spectrometer sporting 0.5% momentum and 0.5 mr angular resolution. As part of the standard SBS detector package the Gas Ring Imaging Cherenkov (GRINCH) detector will help identify particles produced in the experiments. To determine which photomultiplier (PMT) tubes would be used in GRINCH, more than 900 29 mm 9125B PMTs were tested. Two models, were used to fit test data. For the parameters relevant to this study, results from both models were found to be equivalent, and will be discussed here.

Windows 2012 Server network security securing your Windows network systems and infrastructure

CERN Document Server

Rountree, Derrick

2013-01-01

Windows 2012 Server Network Security provides the most in-depth guide to deploying and maintaining a secure Windows network. The book drills down into all the new features of Windows 2012 and provides practical, hands-on methods for securing your Windows systems networks, including: Secure remote access Network vulnerabilities and mitigations DHCP installations configuration MAC filtering DNS server security WINS installation configuration Securing wired and wireless connections Windows personal firewall

Windows 8.1 bible

CERN Document Server

Boyce, Jim; Tidrow, Rob

2014-01-01

Windows 8.1 coverage that goes above and beyond all competitors? Serving as an evolutionary update to Windows 8, Windows 8.1 provides critical changes to parts of Windows 8, such as greater customization of the interface and boot operations, return of a 'start button' that reveals apps, greater integration between the two interfaces, and updates to apps. Weighing in at nearly 1000 pages, Windows 8.1 Bible provides deeper Windows insight than any other book on the market. It's valuable for both professionals needing a guide to the nooks and crannies of Windows and regular users wanting a wide

Impact of fusion-fission hybrids on world nuclear future

International Nuclear Information System (INIS)

Abdel-Khalick, S.; Jansen, P.; Kessler, G.; Klumpp, P.

1980-08-01

An investigation has been conducted to examine the impact of fusion-fission hybrids on world nuclear future. The primary objectives of this investigation have been: (1) to determine whether hybrids can allow us to meet the projected nuclear component of the world energy demand within current estimates of uranium resources without fast breeders, and (2) to identify the preferred hybrid concept from a resource standpoint. The results indicate that hybrids have the potential to lower the world uranium demand to values well below the resource base. However, the time window for hybrid introduction is quite near and narrow (2000-2020). If historical market penetration rates are assumed, the demand will not be met within the resource base unless hybrids are coupled to the breeders. The results also indicate that from a resource standpoint hybrids which breed their own tritium and have a low blanket energy multiplication are preferable. (orig.) [de

Operation and first results of the NEXT-DEMO prototype using a silicon photomultiplier tracking array

International Nuclear Information System (INIS)

Álvarez, V; Cárcel, S; Cervera, A; Díaz, J; Ferrario, P; Gil, A; Borges, F I G; Conde, C A N; Dias, T H V T; Fernandes, L M P; Freitas, E D C; Castel, J; Cebrián, S; Dafni, T; Egorov, M; Gehman, V M; Goldschmidt, A; Esteve, R; Evtoukhovitch, P; Ferreira, A L

2013-01-01

NEXT-DEMO is a high-pressure xenon gas TPC which acts as a technological test-bed and demonstrator for the NEXT-100 neutrinoless double beta decay experiment. In its current configuration the apparatus fully implements the NEXT-100 design concept. This is an asymmetric TPC, with an energy plane made of photomultipliers and a tracking plane made of silicon photomultipliers (SiPM) coated with TPB. The detector in this new configuration has been used to reconstruct the characteristic signature of electrons in dense gas, demonstrating the ability to identify the MIP and ''blob'' regions. Moreover, the SiPM tracking plane allows for the definition of a large fiducial region in which an excellent energy resolution of 1.82% FWHM at 511 keV has been measured (a value which extrapolates to 0.83% at the xenon Q ββ )

Lowering the radioactivity of the photomultiplier tubes for the XENON1T dark matter experiment

Energy Technology Data Exchange (ETDEWEB)

Aprile, E.; Contreras, H.; Goetzke, L.W.; Fernandez, A.J.M.; Messina, M.; Plante, G.; Rizzo, A. [Columbia University, Physics Department, New York, NY (United States); Agostini, F. [INFN-Laboratori Nazionali del Gran Sasso (Italy); Gran Sasso Science Institute, L' Aquila (Italy); Bologna Univ., Department of Physics and Astrophysics, Bologna (Italy); INFN, Bologna (Italy); Alfonsi, M. [Nikhef and the University of Amsterdam, Amsterdam (Netherlands); Johannes Gutenberg-Universitaet Mainz, Institut fuer Physik and Exzellenzcluster PRISMA, Mainz (Germany); Arazi, L.; Budnik, R.; Duchovni, E.; Gross, E.; Itay, R.; Landsman, H.; Lellouch, D.; Levinson, L.; Priel, N.; Vitells, O. [Weizmann Institute of Science, Department of Particle Physics and Astrophysics, Rehovot (Israel); Arisaka, K.; Lyashenko, A.; Meng, Y.; Pantic, E.; Teymourian, A.; Wang, H. [University of California, Physics and Astronomy Department, Los Angeles, CA (United States); Arneodo, F.; Di Giovanni, A. [New York University Abu Dhabi, Abu Dhabi (United Arab Emirates); Auger, M.; Barrow, P.; Baudis, L.; Behrens, A.; Galloway, M.; Kessler, G.; Kish, A.; Mayani, D.; Pakarha, P.; Piastra, F. [University of Zurich, Physik-Institut, Zurich (Switzerland); Balan, C.; Cardoso, J.M.R.; Lopes, J.A.M.; Santos, J.M.F. dos [University of Coimbra, Department of Physics, Coimbra (Portugal); Bauermeister, B.; Fattori, S.; Geis, C.; Grignon, C.; Oberlack, U.; Schindler, S. [Johannes Gutenberg-Universitaet Mainz, Institut fuer Physik and Exzellenzcluster PRISMA, Mainz (Germany); Beltrame, P. [Weizmann Institute of Science, Department of Particle Physics and Astrophysics, Rehovot (Israel); University of Edinburgh, Edinburgh (United Kingdom); Brown, A.; Lang, R.F.; Macmullin, S.; Pienaar, J.; Reichard, S.; Reuter, C. [Purdue University, Department of Physics and Astronomy, West Lafayette, IN (United States); Brown, E.; Levy, C. [Rensselaer Polytechnic Institute, Department of Physics, Applied Physics and Astronomy, Troy, NY (United States); Wilhelms-Universitaet Muenster, Institut fuer Kernphysik, Muenster (Germany); Bruenner, S.; Hampel, W.; Kaether, F.; Lindemann, S.; Lindner, M.; Undagoitia, T.M.; Rauch, L.; Schreiner, J.; Simgen, H.; Weber, M. [Max-Planck-Institut fuer Kernphysik, Heidelberg (Germany); Bruno, G. [INFN-Laboratori Nazionali del Gran Sasso and Gran Sasso Science Institute, L' Aquila (Italy); Wilhelms-Universitaet Muenster, Institut fuer Kernphysik, Muenster (Germany); Buetikofer, L.; Coderre, D.; Schumann, M. [University of Bern, Albert Einstein Center for Fundamental Physics, Bern (Switzerland); Colijn, A.P.; Decowski, M.P.; Tiseni, A.; Tunnell, C. [Nikhef and the University of Amsterdam, Amsterdam (Netherlands); Cussonneau, J.P.; Le Calloch, M.; Masbou, J.; Lavina, L.S.; Thers, D. [Universite de Nantes, Subatech, Ecole des Mines de Nantes, CNRS/In2p3, Nantes (France); Ferella, A.D.; Fulgione, W.; Laubenstein, M. [INFN-Laboratori Nazionali del Gran Sasso and Gran Sasso Science Institute, L' Aquila (Italy); Fieguth, A.; Murra, M.; Rosendahl, S.; Weinheimer, C. [Wilhelms-Universitaet Muenster, Institut fuer Kernphysik, Muenster (Germany); Garbini, M.; Massoli, F.V.; Sartorelli, G.; Selvi, M. [Bologna Univ., Department of Physics and Astrophysics, Bologna (Italy); INFN, Bologna (Italy); Miguez, B.; Molinario, A.; Trinchero, G. [INFN-Torino and Osservatorio Astrofisico di Torino, Turin (Italy); Naganoma, J.; Shagin, P.; Wall, R. [Rice University, Department of Physics and Astronomy, Houston, TX (United States); Orrigo, S.E.A. [University of Coimbra, Department of Physics, Coimbra (Portugal); IFIC, CSIC-Universidad de Valencia, Valencia (Spain); Persiani, R. [Universite de Nantes, Subatech, Ecole des Mines de Nantes, CNRS/In2p3, Nantes (FR); Bologna Univ., Department of Physics and Astrophysics, Bologna (IT); INFN, Bologna (IT); Collaboration: XENON Collaboration

2015-11-15

The low-background, VUV-sensitive 3-inch diameter photomultiplier tube R11410 has been developed by Hamamatsu for dark matter direct detection experiments using liquid xenon as the target material. We present the results from the joint effort between the XENON collaboration and the Hamamatsu company to produce a highly radio-pure photosensor (version R11410-21) for the XENON1T dark matter experiment. After introducing the photosensor and its components, we show the methods and results of the radioactive contamination measurements of the individual materials employed in the photomultiplier production. We then discuss the adopted strategies to reduce the radioactivity of the various PMT versions. Finally, we detail the results from screening 286 tubes with ultra-low background germanium detectors, as well as their implications for the expected electronic and nuclear recoil background of the XENON1T experiment. (orig.)

Detection of cosmic ray tracks using scintillating fibers and position sensitive multi-anode photomultipliers

International Nuclear Information System (INIS)

Atac, M.; Streets, J.; Wilcer, N.

1998-02-01

This experiment demonstrates detection of cosmic ray tracks by using Scintillating fiber planes and multi-anode photomultipliers (MA-PMTs). In a laboratory like this, cosmic rays provide a natural source of high-energy charged particles which can be detected with high efficiency and with nanosecond time resolution

CLARO: an ASIC for high rate single photon counting with multi-anode photomultipliers

Science.gov (United States)

Baszczyk, M.; Carniti, P.; Cassina, L.; Cotta Ramusino, A.; Dorosz, P.; Fiorini, M.; Gotti, C.; Kucewicz, W.; Malaguti, R.; Pessina, G.

2017-08-01

The CLARO is a radiation-hard 8-channel ASIC designed for single photon counting with multi-anode photomultiplier tubes. Each channel outputs a digital pulse when the input signal from the photomultiplier crosses a configurable threshold. The fast return to baseline, typically within 25 ns, and below 50 ns in all conditions, allows to count up to 107 hits/s on each channel, with a power consumption of about 1 mW per channel. The ASIC presented here is a much improved version of the first 4-channel prototype. The threshold can be precisely set in a wide range, between 30 ke- (5 fC) and 16 Me- (2.6 pC). The noise of the amplifier with a 10 pF input capacitance is 3.5 ke- (0.6 fC) RMS. All settings are stored in a 128-bit configuration and status register, protected against soft errors with triple modular redundancy. The paper describes the design of the ASIC at transistor-level, and demonstrates its performance on the test bench.

YAP and the Hippo pathway in pediatric cancer.

Science.gov (United States)

Ahmed, Atif A; Mohamed, Abdalla D; Gener, Melissa; Li, Weijie; Taboada, Eugenio

2017-01-01

The Hippo pathway is an important signaling pathway that controls cell proliferation and apoptosis. It is evolutionarily conserved in mammals and is stimulated by cell-cell contact, inhibiting cell proliferation in response to increased cell density. During early embryonic development, the Hippo signaling pathway regulates organ development and size, and its functions result in the coordinated balance between proliferation, apoptosis, and differentiation. Its principal effectors, YAP and TAZ, regulate signaling by the embryonic stem cells and determine cell fate and histogenesis. Dysfunction of this pathway contributes to cancer development in adults and children. Emerging studies have shed light on the upregulation of Hippo pathway members in several pediatric cancers and may offer prognostic information on rhabdomyosarcoma, osteosarcoma, Wilms tumor, neuroblastoma, medulloblastoma, and other brain gliomas. We review the results of such published studies and highlight the potential clinical application of this pathway in pediatric oncologic and pathologic studies. These studies support targeting this pathway as a novel treatment strategy.

Development of an application specific scintimammography detector based on a crystal scintillator array and a PSPMT

CERN Document Server

Majewski, S; Goode, A; Kross, B J; Steinbach, D; Weisenberger, A; Williams, M; Wojci, R

1998-01-01

We report the results of studies conducted with small field of view scintimammography camera based on a position-sensitive photomultiplier tube (5'' Hamamatsu R3292) and several pixelized crystal scintillator arrays made of YAP, CsI(Na) and NaI(Tl) scintillators. Laboratory tests and pre-clinical phantom studies were conducted to compare and optimize the performances of the prototypes with special emphasis on spatial resolution (approx 2-3mm) and sufficient energy resolution for scatter rejection.

Flexible transparent aerogels as window retrofitting films and optical elements with tunable birefringence

Energy Technology Data Exchange (ETDEWEB)

Liu, Qingkun; Frazier, Allister W.; Zhao, Xinpeng; De La Cruz, Joshua A.; Hess, Andrew J.; Yang, Ronggui; Smalyukh, Ivan I.

2018-06-01

Experimental realization of optically transparent, mechanically robust and flexible aerogels has been a longstanding challenge, which limits their practical applications in energy-saving devices, such as thermally insulating films for enhancing energy efficiency of windows. The poor transparency precluded even hypothetical consideration of the possibility of birefringent aerogels. We develop birefringent and optically isotropic aerogels that combine properties of thermal super-insulation, mechanical robustness and flexibility, and transparency to visible-spectrum light. This unusual combination of physical properties is achieved by combining liquid crystalline self-organization of cellulose nanofibers with polysiloxane cross-linking and control of the nanoscale porosity to form hybrid organic-inorganic mesostructured aerogels. Potential applications of these inexpensive materials range from single pane window retrofitting to smart fabrics.

LYSO crystal calorimeter readout with silicon photomultipliers

Energy Technology Data Exchange (ETDEWEB)

Berra, A., E-mail: alessandro.berra@gmail.com [Università degli Studi dell' Insubria (Italy); INFN sezione di Milano Bicocca (Italy); Bonvicini, V. [INFN sezione di Trieste (Italy); Cecchi, C.; Germani, S. [INFN sezione di Perugia (Italy); Guffanti, D. [Università degli Studi dell' Insubria (Italy); Lietti, D. [Università degli Studi dell' Insubria (Italy); INFN sezione di Milano Bicocca (Italy); Lubrano, P.; Manoni, E. [INFN sezione di Perugia (Italy); Prest, M. [Università degli Studi dell' Insubria (Italy); INFN sezione di Milano Bicocca (Italy); Rossi, A. [INFN sezione di Perugia (Italy); Vallazza, E. [INFN sezione di Trieste (Italy)

2014-11-01

Large area Silicon PhotoMultipliers (SiPMs) are the new frontier of the development of readout systems for scintillating detectors. A SiPM consists of a matrix of parallel-connected silicon micropixels operating in limited Geiger–Muller avalanche mode, and thus working as independent photon counters with a very high gain (∼10{sup 6}). This contribution presents the performance in terms of linearity and energy resolution of an electromagnetic homogeneous calorimeter composed of 9∼18X{sub 0} LYSO crystals. The crystals were readout by 36 4×4 mm{sup 2} SiPMs (4 for each crystal) produced by FBK-irst. This calorimeter was tested at the Beam Test Facility at the INFN laboratories in Frascati with a single- and multi-particle electron beam in the 100–500 MeV energy range.

Ultrafast readout of scintillating fibers using upgraded position-sensitive photomultipliers

International Nuclear Information System (INIS)

Onel, Y.

1994-01-01

Experimental results obtained with commercially available position-sensitive photomultipliers (PSPM) coupled with 0.5 mm diameter scintillating fiber arrays show some promising performances such as space resolution better than 200 μm and time resolution ∼ 1.5 ns with a detection efficiency higher than 90%. Major progress has also been recently achieved with an upgrade of a PSPM based on new grid dynode structures. Two-track spatial resolution has been studied using the upgraded PSPM. Initial studies demonstrate that two tracks separated by a minimum distance of 3 mm are resolved

Impact of fusion-fission hybrids on world nuclear future

International Nuclear Information System (INIS)

Abdel-Khalik, S.I.; Jansen, P.; Kessler, G.; Klumpp, P.

1981-01-01

An investigation has been conducted to examine the impact of fusion-fission hybrids on world nuclear future. The primary objectives of this investigation have been: (1) to determine whether hybrids can allow us to meet the projected nuclear component of the world energy demand within current estimates of uranium resources with or without fast breeders, and (2) to identify the preferred hybrid concept from a resource standpoint. The results indicate that hybrids have the potential to lower the world uranium demand to values well below the resource base. However, the time window for hybrid introduction is quite near and narrow (2000-2020). If historical market penetration rates are assumed, the demand will not be met within the resource base unless hybrids are coupled to the breeders. The results also indicate that from a resource standpoint hybrids which breed their own tritium and have a low blanket energy multiplication are preferable. (orig.) [de

Impact of fusion-fission hybrids on world nuclear future

International Nuclear Information System (INIS)

Abdel-Khalik, S.I.

1980-01-01

An investigation has been conducted to examine the impact of fusion-fission hybrids on world nuclear future. The primary objectives of this investigation have been (1) to determine whether hybrids can allow us to meet the projected nuclear component of the world energy demand within current estimates of uranium resources with or without fast breeders, and (2) to identify the preferred hybrid concept from a resource standpoint. The results indicate that hybrids have the potential to lower the world uranium demand to values well below the resource base. However, the time window for hybrid introduction is quite near and narrow (2000-2020). If historical market penetration rates are assumed, the demand will not be met within the resource base unless hybrides are coupled to the breeders. The results also indicate that from a resource standpaint hybrids which breed their own tritium and have a low blanket energy multiplication are preferable. (orig.) [de

A study of timing properties of Silicon Photomultipliers

Science.gov (United States)

Avella, Paola; De Santo, Antonella; Lohstroh, Annika; Sajjad, Muhammad T.; Sellin, Paul J.

2012-12-01

Silicon Photomultipliers (SiPMs) are solid-state pixelated photodetectors. Lately these sensors have been investigated for Time of Flight Positron Emission Tomography (ToF-PET) applications, where very good coincidence time resolution of the order of hundreds of picoseconds imply spatial resolution of the order of cm in the image reconstruction. The very fast rise time typical of the avalanche discharge improves the time resolution, but can be limited by the readout electronics and the technology used to construct the device. In this work the parameters of the equivalent circuit of the device that directly affect the pulse shape, namely the quenching resistance and capacitance and the diode and parasitic capacitances, were calculated. The mean rise time obtained with different preamplifiers was also measured.

Efficient Windows Collaborative

Energy Technology Data Exchange (ETDEWEB)

Nils Petermann

2010-02-28

The project goals covered both the residential and commercial windows markets and involved a range of audiences such as window manufacturers, builders, homeowners, design professionals, utilities, and public agencies. Essential goals included: (1) Creation of 'Master Toolkits' of information that integrate diverse tools, rating systems, and incentive programs, customized for key audiences such as window manufacturers, design professionals, and utility programs. (2) Delivery of education and outreach programs to multiple audiences through conference presentations, publication of articles for builders and other industry professionals, and targeted dissemination of efficient window curricula to professionals and students. (3) Design and implementation of mechanisms to encourage and track sales of more efficient products through the existing Window Products Database as an incentive for manufacturers to improve products and participate in programs such as NFRC and ENERGY STAR. (4) Development of utility incentive programs to promote more efficient residential and commercial windows. Partnership with regional and local entities on the development of programs and customized information to move the market toward the highest performing products. An overarching project goal was to ensure that different audiences adopt and use the developed information, design and promotion tools and thus increase the market penetration of energy efficient fenestration products. In particular, a crucial success criterion was to move gas and electric utilities to increase the promotion of energy efficient windows through demand side management programs as an important step toward increasing the market share of energy efficient windows.

Effect of the method of photomultiplier gain control on electron time-of-flight in FEhU-30

International Nuclear Information System (INIS)

Gladyshev, D.A.; Li, B.N.

1979-01-01

The effect of a method of control of the multiplication factor of a photomultiplier on the electron flight time has been investigated. Presented are the results of measuring the dependence of the electron flight time for the following methods of stabilizing the photomultiplier multiplication: adjustment of multiplication by changing the supply voltage; control of multiplication with the help of a resistor which shunts two neighbouring interdynode gaps, and the control of the multiplication factor by changing a magnetic field caused due to changes in the current flowing through a special solenoid. It has been found that in these methods changes in the flight time constituted 260 and 140 ns. Magnetic-field control does not affect the flight time with an accuracy of up to 20 ps

Ionic-Liquid-Tethered Nanoparticles: Hybrid Electrolytes

KAUST Repository

Moganty, Surya S.

2010-10-22

A new class of solventless electrolytes was created by tethering ionic liquids to hard inorganic ZrO2 nanostructures (see picture; NIM=nanoscale ionic material). These hybrid fluids exhibit exceptional redox stability windows, excellent thermal stability, good lithium transference numbers, long-term interfacial stability in the presence of a lithium anode and, when doped with lithium salt, reasonable ionic conductivities.

Objective-function Hybridization in Adjoint Seismic Tomography

Science.gov (United States)

Yuan, Y. O.; Bozdag, E.; Simons, F.; Gao, F.

2016-12-01

In the realm of seismic tomography, we are at the threshold of a new era of huge seismic datasets. However, how to assimilate as much information as possible from every seismogram is still a challenge. Cross-correlation measurements are generally tailored to some window selection algorithms, such as FLEXWIN (Maggie et al. 2008), to balance amplitude differences between seismic phases. However, these measurements naturally favor maximum picks in selected windows. It is also difficult to select all usable portions of seismograms in an optimum way that lots of information is generally lost, particularly the scattered waves. Instantaneous phase type of misfits extract information from every wiggle without cutting seismograms into small pieces, however, dealing with cycle skips at short periods can be challenging. For this purpose, we introduce a flexible hybrid approach for adjoint seismic tomography, to combine various objective functions. We initially focus on phase measurements and propose using instantaneous phase to take into account relatively small-magnitude scattered waves at long periods while using cross-correlation measurements on FLEXWIN windows to select distinct body-wave arrivals without complicating measurements due to non-linearities at short periods. To better deal with cycle skips and reliably measure instantaneous phases we design a new misfit function that incorporates instantaneous phase information implicitly instead of measuring it explicitly, through using normalized analytic signals. We present in our synthetic experiments how instantaneous phase, cross-correlation and their hybridization affect tomographic results. The combination of two different phase measurements in a hybrid approach constitutes progress towards using "anything and everything" in a data set, addressing data quality and measurement challenges simultaneously. We further extend hybridisation of misfit functions for amplitude measurements such as cross-correlation amplitude

Test of a position-sensitive photomultiplier for fast scintillating fiber detector read-out

International Nuclear Information System (INIS)

Baehr, J.; Hoffmann, B.; Luedecke, H.; Nahnhauer, R.; Pohl, M.; Roloff, H.E.

1993-01-01

A position-sensitive photomultiplier with 256 anode pixels has been used to read out scintillating fibers excited by light emitting diodes, electrons from a β-source and a 5 GeV electron beam. Measurements have been done within a magnetic field up to 0.6 T. Tracking and electromagnetic shower detection capabilities of a simple fiber detector have been studied. (orig.)

Windows 10 for dummies

CERN Document Server

Rathbone, Andy

2015-01-01

The fast and easy way to get up and running with Windows 10 Windows 10 For Dummies covers the latest version of Windows and gets you up and running with the changes and new features you'll find in this updated operating system. Packed with time-saving tips to help you get the most out of the software, this helpful Windows 10 guide shows you how to manage Windows tasks like navigating the interface with a mouse or touchscreen, connecting to the web, and troubleshooting problems and making quick fixes. Assuming no prior knowledge of the software, Windows 10 For Dummies addresses the updates to

Transcriptomic profiling of chemical exposure reveals roles of Yap1 in protecting yeast cells from oxidative and other types of stresses.

Science.gov (United States)

Zhang, Chao; Li, Zhouquan; Zhang, Xiaohua; Yuan, Li; Dai, Heping; Xiao, Wei

2016-01-01

Transcriptomic profiles are generated by comparing wild-type and the yeast yap1 mutant to various chemicals in an attempt to establish a correlation between this gene mutation and chemical exposure. Test chemicals include ClonNAT as a non-genotoxic agent, methyl methanesulphonate (MMS) as an alkylating agent, tert-butyl hydroperoxide (t-BHP) as an oxidative agent and the mixture of t-BHP and MMS to reflect complex natural exposure. Differentially expressed genes (DEGs) were identified and specific DEGs were obtained by excluding overlapping DEGs with the control group. In the MMS exposure group, deoxyribonucleotide biosynthetic processes were upregulated, while oxidation-reduction processes were downregulated. In the t-BHP exposure group, metabolic processes were upregulated while peroxisome and ion transport pathways were downregulated. In the mixture exposure group, the proteasome pathway was upregulated, while the aerobic respiration was downregulated. Homologue analysis of DEGs related to human diseases showed that many of DEGs were linked to cancer, ageing and neuronal degeneration. These observations confirm that the yap1 mutant is more sensitive to chemicals than wild-type cells and that the susceptible individuals carrying the YAP1-like gene defect may enhance risk to chemical exposure. Hence, this study offers a novel approach to environmental risk assessment, based on the genetic backgrounds of susceptible individuals. Copyright © 2015 John Wiley & Sons, Ltd.

Provide Views | Efficient Windows Collaborative

Science.gov (United States)

Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

Reduced Fading | Efficient Windows Collaborative

Science.gov (United States)

Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

EWC Members | Efficient Windows Collaborative

Science.gov (United States)

Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

Visible Transmittance | Efficient Windows Collaborative

Science.gov (United States)

Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

Gas Fills | Efficient Windows Collaborative

Science.gov (United States)

Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

EWC Membership | Efficient Windows Collaborative

Science.gov (United States)

Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

Reducing Condensation | Efficient Windows Collaborative

Science.gov (United States)

Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

Improved Comfort | Efficient Windows Collaborative

Science.gov (United States)

Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

Financing & Incentives | Efficient Windows Collaborative

Science.gov (United States)

Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

Tools & Resources | Efficient Windows Collaborative

Science.gov (United States)

Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

Books & Publications | Efficient Windows Collaborative

Science.gov (United States)

Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

Design Considerations | Efficient Windows Collaborative

Science.gov (United States)

Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

Windows forensic analysis toolkit advanced analysis techniques for Windows 7

CERN Document Server

Carvey, Harlan

2012-01-01

Now in its third edition, Harlan Carvey has updated "Windows Forensic Analysis Toolkit" to cover Windows 7 systems. The primary focus of this edition is on analyzing Windows 7 systems and on processes using free and open-source tools. The book covers live response, file analysis, malware detection, timeline, and much more. The author presents real-life experiences from the trenches, making the material realistic and showing the why behind the how. New to this edition, the companion and toolkit materials are now hosted online. This material consists of electronic printable checklists, cheat sheets, free custom tools, and walk-through demos. This edition complements "Windows Forensic Analysis Toolkit, 2nd Edition", (ISBN: 9781597494229), which focuses primarily on XP. It includes complete coverage and examples on Windows 7 systems. It contains Lessons from the Field, Case Studies, and War Stories. It features companion online material, including electronic printable checklists, cheat sheets, free custom tools, ...

Advanced energy efficient windows

DEFF Research Database (Denmark)

Thomsen, Kirsten Engelund

2007-01-01

Windows should be paid special attention as they contribute a significant part of the total heat-loss coefficient of the building. Contrary to other parts of the thermal envelope the windows are not only heat loosers, but may gain heat in the day-time. Therefore there are possibilities for large...... energy savings. In terms of energy, windows occupy a special position compared with other thermal envelope structures due to their many functions: 1) windows let daylight into the building and provide occupants with visual contact with their surroundings 2) windows protect against the outdoor climate 3......) windows transmit solar energy that may contribute to a reduction of energy consumption, but which may also lead to unpleasant overheating. In the following paragraphs the current use of windows is reviewed with an emphasis on energy, while special products like solar protection glazing and security...

SensL B-Series and C-Series silicon photomultipliers for time-of-flight positron emission tomography

Energy Technology Data Exchange (ETDEWEB)

O' Neill, K., E-mail: koneill@sensl.com; Jackson, C., E-mail: cjackson@sensl.com

2015-07-01

Silicon photomultipliers from SensL are designed for high performance, uniformity and low cost. They demonstrate peak photon detection efficiency of 41% at 420 nm, which is matched to the output spectrum of cerium doped lutetium orthosilicate. Coincidence resolving time of less than 220 ps is demonstrated. New process improvements have lead to the development of C-Series SiPM which reduces the dark noise by over an order of magnitude. In this paper we will show characterization test results which include photon detection efficiency, dark count rate, crosstalk probability, afterpulse probability and coincidence resolving time comparing B-Series to the newest pre-production C-Series. Additionally we will discuss the effect of silicon photomultiplier microcell size on coincidence resolving time allowing the optimal microcell size choice to be made for time of flight positron emission tomography systems.

Positioning of aquatic animals based on time-of-arrival and random walk models using YAPS (Yet Another Positioning Solver)

DEFF Research Database (Denmark)

Baktoft, Henrik; Gjelland, Karl Øystein; Økland, Finn

2017-01-01

Aquatic positional telemetry offers vast opportunities to study in vivo behaviour of wild animals, but there is room for improvement in the data quality provided by current procedures for estimating positions. Here we present a novel positioning method called YAPS (Yet Another Positioning Solver...

Windows 8 secrets

CERN Document Server

Thurrott, Paul

2012-01-01

Tips, tricks, treats, and secrets revealed on Windows 8 Microsoft is introducing a major new release of its Windows operating system, Windows 8, and what better way to learn all its ins and outs than from two internationally recognized Windows experts and Microsoft insiders, authors Paul Thurrott and Rafael Rivera? They cut through the hype to get at useful information you'll not find anywhere else, including what role this new OS plays in a mobile and tablet world. Regardless of your level of knowledge, you'll discover little-known facts about how things work, what's new and different, and h

Programming Windows Azure

CERN Document Server

Krishnan, Sriram

2010-01-01

Learn the nuts and bolts of cloud computing with Windows Azure, Microsoft's new Internet services platform. Written by a key member of the product development team, this book shows you how to build, deploy, host, and manage applications using Windows Azure's programming model and essential storage services. Chapters in Programming Windows Azure are organized to reflect the platform's buffet of services. The book's first half focuses on how to write and host application code on Windows Azure, while the second half explains all of the options you have for storing and accessing data on the plat

Beginning Windows 8

CERN Document Server

Halsey, Mike

2012-01-01

Windows 8 has been described by Microsoft as its 'boldest' Windows release ever. Beginning Windows 8 takes you through the new features and helps you get more out of the familiar to reveal the possibilities for this amazing new operating system. You will learn, with non-technical language used throughout, how to get up and running in the new Windows interface, minimize downtime, maximize productivity, and harness the features you never knew existed to take control of your computer and enjoy the peace of mind and excitement that comes with it. From tips and tweaks to easy-to-follow guides and d

Windows 8 tweaks

CERN Document Server

Sinchak, Steve

2013-01-01

Acres of Windows 8 tweaks from a Microsoft MVP and creator of Tweaks.com! From a Microsoft MVP, who is also the savvy creator of Tweaks.com, comes this ultimate collection of Windows 8 workarounds. Steve Sinchak takes you way beyond default system settings, deep under the hood of Windows 8, down to the hidden gems that let you customize your Windows 8 system like you wouldn't believe. From helping you customize the appearance to setting up home networking, sharing media, and squeezing every ounce of performance out of the OS, this book delivers. Get ready to rock and roll with Wind

The STiC ASIC. High precision timing with silicon photomultipliers

International Nuclear Information System (INIS)

Harion, Tobias

2015-01-01

In recent years, Silicon Photomultipliers are being increasingly used for Time of Flight measurements in particle detectors. To utilize the high intrinsic time resolution of these sensors in detector systems, the development of specialized, highly integrated readout electronics is required. In this thesis, a mixed-signal application specific integrated circuit, named STiC, has been developed, characterized and integrated in a detector system. STiC has been specifically designed for high precision timing measurements with SiPMs, and is in particular dedicated to the EndoTOFPET-US project, which aims to achieve a coincidence time resolution of 200 ps FWHM and an energy resolution of less than 20% in an endoscopic positron emission tomography system. The chip integrates 64 high precision readout channels for SiPMs together with a digital core logic to process, store and transfer the recorded events to a data acquisition system. The performance of the chip has been validated in coincidence measurements using detector modules consisting of 3.1 x 3.1 x 15 mm 3 LYSO crystals coupled to Silicon Photomultipliers from Hamamatsu. The measurements show an energy resolution of 15% FWHM for the detection of 511 keV photons. A coincidence time resolution of 213 ps FWHM has been measured, which is among the best resolution values achieved to date with this detector topology. STiC has been integrated in the EndoTOFPET-US detector system and has been chosen as the baseline design for the readout of SiPM sensors in the Mu3e experiment.

Radiation Damage Studies of Silicon Photomultipliers

CERN Document Server

Bohn, P; Hazen, E.; Heering, A.; Rohlf, J.; Freeman, J.; Los, Sergey V.; Cascio, E.; Kuleshov, S.; Musienko, Y.; Piemonte, C.

2008-01-01

We report on the measurement of the radiation hardness of silicon photomultipliers (SiPMs) manufactured by Fondazione Bruno Kessler in Italy (1 mm$^2$ and 6.2 mm$^2$), Center of Perspective Technology and Apparatus in Russia (1 mm$^2$ and 4.4 mm$^2$), and Hamamatsu Corporation in Japan (1 mm$^2$). The SiPMs were irradiated using a beam of 212 MeV protons at Massachusetts General Hospital, receiving fluences of up to $3 \\times 10^{10}$ protons per cm$^2$ with the SiPMs at operating voltage. Leakage currents were read continuously during the irradiation. The delivery of the protons was paused periodically to record scope traces in response to calibrated light pulses to monitor the gains, photon detection efficiencies, and dark counts of the SiPMs. The leakage current and dark noise are found to increase with fluence. Te leakage current is found to be proportional to the mean square deviation of the noise distribution, indicating the dark counts are due to increased random individual pixel activation, while SiPM...

Lowering the radioactivity of the photomultiplier tubes for the XENON1T dark matter experiment

NARCIS (Netherlands)

Aprile, E.; et al., [Unknown; Alfonsi, M.; Colijn, A.P.; Decowski, M.P.; Tiseni, A.; Tunnell, C.

2015-01-01

The low-background, VUV-sensitive 3-inch diameter photomultiplier tube R11410 has been developed by Hamamatsu for dark matter direct detection experiments using liquid xenon as the target material. We present the results from the joint effort between the XENON collaboration and the Hamamatsu company

Blocking of photomultiplier tubes; Blocage de tubes photomultiplicateurs

Energy Technology Data Exchange (ETDEWEB)

Andrivet, J [Commissariat a l' Energie Atomique, Limeil-Brevannes (France). Centre d' Etudes

1968-07-01

Development of a very simple apparatus having a single transistor. The gain is reduced by a factor of 1.5 to 3 x 10{sup 2} for the photomultipliers XP 1002, and of 10{sup 3} to 10{sup 4} for the photomultipliers 56-AVP and TVP. Blocking can be achieved in 40 ns if necessary (using a TRS-350 transistor), and the time required to return to the initial gain can be no longer than 40 ns with a TRS-200, for the blocking of several micro-seconds for example. 1000 {mu}s and above can be obtained with switching times which are longer but which can be less than 150 ns if needs be. An outside insulated supply can be avoided if the recurrence is low. A standard pulse generator is used for triggering. There is no other electronic equipment, and the device can be fitted easily into the space of the voltage divider. (author) [French] Etude et realisation d'un montage tres simple utilisant un seul transistor. Le gain est reduit d'un facteur 1.5 a 3.10{sup 2} sur des photomultiplicateurs XP 1002, et 10{sup 3} a 10{sup 4} sur les photomultiplicateurs 56 AVP et TVP. Le blocage peut etre atteint en 40 ns si necessaire (avec un transistor TRS-350), et le temps de retour au gain initial peut ne pas depasser 40 ns avec un TRS-200, pour des blocages de plusieurs micro-secondes, par exemple. On peut obtenir plus de 1000 {mu}s avec des temps de commutation plus importants, mais qui peuvent si besoin est ne pas etre superieurs a 150 ns. L'alimentation exterieure isolee peut etre evitee si la recurrence est faible. Pour le declenchement on utilise un generateur d'impulsions standard. Il n'y a aucune autre electronique, et le montage s'integre aisement dans l'encombrement du pont d'alimentation. (auteur)

Test on 2,000 photomultipliers for the CDF endplug calorimeter upgrade

International Nuclear Information System (INIS)

Fiori, I.

1997-01-01

A systematic test of various characteristics, such as gain, dark current, maximum peak current, stability and relative quantum efficiency, has been made to evaluate about 2,000 photomultiplier tubes for the upgraded CDF Endplug calorimeters. The phototubes are Hamamatsu R4125,19mm diameter with green-extended photocathode. In this report we discuss the distribution of the major characteristics measured and the failure mode. Comparisons between independent measurements made on some of the characteristics are used to evaluate the quality of the measurement itself

Effect of interelectrode potentials in the photomultiplier on formation of afterpulses

International Nuclear Information System (INIS)

Morozov, V.A.; Morozova, N.V.

2001-01-01

The effect of the interelectrode potential difference in the XP2020 photomultiplier on the intensity of formation of afterpulses caused by ion feedback is studied. It is shown that the photocathode - first dynode gap plays a decisive role in this process while the dynode system is of minor importance at pulse currents below a few tens of milliampers. It is also shown that the anomalous ratio between the afterpulse amplitudes and basic pulse amplitudes can be governed by the process of single ion detection. (author)

Kırgız Atasözlerinin Cümle Yapısı Üzerinde Bazı Gözlemler Some Observations On The Sentence Structures of The Kirghiz Proverbs

Directory of Open Access Journals (Sweden)

Mevlüt GÜLTEKİN

2013-03-01

�alışmamızda, çoğunu, Kırgızistan’da yayımlanmış Bir Miñ Kırgız Eliniñ Makal-Lakaptarı (BM adlı eserle Türkiye’de çıkmış Kırgız Atasözleri (KA adlı iki çalışmadan aldığımız, 97 Kırgız atasözünü cümle yapıları bakımından gözden geçireceğiz. Kalıplaşmış ifade biçimlerinden biri olan Kırgız atasözlerini, cümle yapıları itibarıyla, 1. Basit, 2. Birleşik, a. sıralı, b. girişik, c. şart, ç. iç içe birleşik ve 3. Karmaşık cümle yapısındaki atasözleri olarak tasnif etmek suretiyle inceleyeceğiz. Basit cümle yapısındaki atasözleri (1-101, anlamca bildirme ve emir cümlesi yapısındakiler olmak üzere ikiye ayrılarak gözden geçireceğiz. Sıralı cümle yapısındaki atasözlerini (11-25 ise, dizilişlerine göre, kurallı ve devrik yapıda olanlar olarak inceleyeceğiz. Şartlı birleşik cümle yapısındaki atasözlerini (26-44 de, zarf tümleci, özne, nesne, yer tamlayıcısı vb. işlevli olanlar biçiminde gözden geçireceğiz. İç içe birleşik cümle yapısındaki atasözlerini (45-55 ise, nesne işlevi gören ve degen sıfat-fiilinin önünde gelip vasıflayıcı olarak kullanılanlar diye ikiye ayırarak ele alacağız. Girişik cümle yapısındaki atasözlerini (58-78 ise, A. isim-fiillerle, B. sıfat-fiillerle, C. zarf-fiillerle kurulan girişik birleşik cümle yapısına sahip atasözleri olarak inceleyecek ve bu fiil gruplarının katıldığı birleşik cümlelerdeki işlevlerine de işaret edeceğiz. İçerdiği temel cümlelerden en az birisi girişik cümlecik veya şart cümleciği yapısındaki iki ya da daha fazla sıralı cümleden veya şartlı birleşik cümleden meydana gelen karmaşık cümle yapısındaki atasözlerini (79-97 ise, makalenin sonunda gözden geçireceğiz.

Simulation of Silicon Photomultiplier Signals

Science.gov (United States)

Seifert, Stefan; van Dam, Herman T.; Huizenga, Jan; Vinke, Ruud; Dendooven, Peter; Lohner, Herbert; Schaart, Dennis R.

2009-12-01

In a silicon photomultiplier (SiPM), also referred to as multi-pixel photon counter (MPPC), many Geiger-mode avalanche photodiodes (GM-APDs) are connected in parallel so as to combine the photon counting capabilities of each of these so-called microcells into a proportional light sensor. The discharge of a single microcell is relatively well understood and electronic models exist to simulate this process. In this paper we introduce an extended model that is able to simulate the simultaneous discharge of multiple cells. This model is used to predict the SiPM signal in response to fast light pulses as a function of the number of fired cells, taking into account the influence of the input impedance of the SiPM preamplifier. The model predicts that the electronic signal is not proportional to the number of fired cells if the preamplifier input impedance is not zero. This effect becomes more important for SiPMs with lower parasitic capacitance (which otherwise is a favorable property). The model is validated by comparing its predictions to experimental data obtained with two different SiPMs (Hamamatsu S10362-11-25u and Hamamatsu S10362-33-25c) illuminated with ps laser pulses. The experimental results are in good agreement with the model predictions.

Thomson scattering measuring device using high sensitivity photomultipliers: 16% up to 860nm

International Nuclear Information System (INIS)

Hesse, M.

1976-03-01

Photomultipliers with high quantum efficiency were used to observe the entire rubis laser light spectrum scattered by a plasma. The optical and electronic acquisition device used to study this spectrum is described. The spectra obtained revealed a dissymmetry larger than that expected from relativistic theory. These results could not be interpreted. The diagnostic sensitivity allows the measurement of low electron densities (2.10 12 ecm -3 ) [fr

Window selection for dual photopeak window scatter correction in Tc-99m imaging

International Nuclear Information System (INIS)

Vries, D.J. de; King, M.A.

1994-01-01

The width and placement of the windows for the dual photopeak window (DPW) scatter subtraction method for Tc-99m imaging is investigated in order to obtain a method that is stable on a multihead detector system for single photon emission computed tomography (SPECT) and is capable of providing a good scatter estimate for extended objects. For various window pairs, stability and noise were examined with experiments using a SPECT system, while Monte Carlo simulations were used to predict the accuracy of scatter estimates for a variety of objects and to guide the development of regression relations for various window pairs. The DPW method that resulted from this study was implemented with a symmetric 20% photopeak window composed of a 15% asymmetric photopeak window and a 5% lower window abutted at 7 keV below the peak. A power function regression was used to relate the scatter-to-total ratio to the lower window-to-total ratio at each pixel, from which an estimated scatter image was calculated. DPW demonstrated good stability, achieved by abutting the two windows away from the peak. Performance was assessed and compared with Compton window subtraction (CWS). For simulated extended objects, DPW generally produced a less biased scatter estimate than the commonly used CWS method with k = 0.5. In acquisitions of a clinical SPECT phantom, contrast recovery was comparable for both DPW and CWS; however, DPW showed greater visual contrast in clinical SPECT bone studies

Fast light pulse measurements and temporal fluctuations in photomultipliers

International Nuclear Information System (INIS)

Miehe, J.A.; Sipp, B.

1975-01-01

This paper reviews the results on time fluctuations in high gain first dynode photomultipliers used in single photon timing experiments; the theoretical analysis of the measurement of the shape of light pulses is recalled and the previously obtained results concerning time dispersion in the photocathode, first dynode space are discussed. In addition, the influence of the variations of the electron transit time in the multiplier on the time resolution curves of the detector is examined: the curves obtained by leading-edge triggering of the anodic pulse show a strong dependence on the threshold level of the discriminator. A single-photoelectron timing resolution of 270ps is measured using a low leading edge discrimination [fr

Continuous wave and AO Q-switch operation Tm,Ho:YAP laser pumped by a laser diode of 798 nm

International Nuclear Information System (INIS)

Li, L J; Yao, B Q; Song, C W; Wang, Y Z; Wang, Z G

2009-01-01

Continuous wave (CW) and acousto-optical (AO) Q-switch operation of Tm (5 at.%), Ho (0.3 at.%):YAP laser at 2.13 μm wavelength were reported in this paper. The Tm,Ho:YAP crystal was cooled by liquid nitrogen and double-end-pumped by a 14.2 W fiber-coupled laser diode at 798 nm. Different resonator lengths and output couplers for the pump power were tried. A maximum conversion efficiency of 31.3% and a maximum slope efficiency of 35.2% were acquired with CW output power of 4.45 W. Average power of 4.21 W was obtained at pulse repetition frequency (PRF) of 15 kHz, corresponding to an optical-to-optical conversion efficiency of 29.6% and a slope efficiency of 32.4%. The energy per pulse of 2.3 mJ in 64 ns was achieved at 1.5 kHz with the peak power of 35.8 kW

Vehicle routing problem with time windows using natural inspired algorithms

Science.gov (United States)

Pratiwi, A. B.; Pratama, A.; Sa’diyah, I.; Suprajitno, H.

2018-03-01

Process of distribution of goods needs a strategy to make the total cost spent for operational activities minimized. But there are several constrains have to be satisfied which are the capacity of the vehicles and the service time of the customers. This Vehicle Routing Problem with Time Windows (VRPTW) gives complex constrains problem. This paper proposes natural inspired algorithms for dealing with constrains of VRPTW which involves Bat Algorithm and Cat Swarm Optimization. Bat Algorithm is being hybrid with Simulated Annealing, the worst solution of Bat Algorithm is replaced by the solution from Simulated Annealing. Algorithm which is based on behavior of cats, Cat Swarm Optimization, is improved using Crow Search Algorithm to make simplier and faster convergence. From the computational result, these algorithms give good performances in finding the minimized total distance. Higher number of population causes better computational performance. The improved Cat Swarm Optimization with Crow Search gives better performance than the hybridization of Bat Algorithm and Simulated Annealing in dealing with big data.

Tarihsel süreç içinde peyzaj tasarım ve uygulama çalışmalarında yapı malzemelerinin kullanımının irdelenmesi

OpenAIRE

Shakouri, Nasim

2010-01-01

Peyzaj, sayısız materyallerden oluşan görsel bir bütünlük olarak tanımlanmaktadır. Bu materyaller zaman içindeki değişimlerle, peyzaj tipi ve karakterini belirlemektedir. Peyzaj mimarlığında kullanılan materyaller, canlı ve cansız materyaller olarak ayrıca tanımlanmaktadır. Cansız materyaller kavramı içinde, peyzaj mimarlığında kullanılan yapısal öğelerin oluşturmasında önemli rol oynayan yapı malzemeleri de yer almaktadır. Peyzaj mimarlığında kullanılan yapısal malzemelerin özellikl...

Silicon photomultiplier's gain stabilization by bias correction for compensation of the temperature fluctuations

Energy Technology Data Exchange (ETDEWEB)

Dorosz, P., E-mail: pdorosz@agh.edu.pl [AGH University of Science and Technology, Faculty of Electrical Engineering, Automatics, Computer Science and Electronics, Department of Electronics, 30-059 Krakow (Poland); Baszczyk, M.; Glab, S. [AGH University of Science and Technology, Faculty of Electrical Engineering, Automatics, Computer Science and Electronics, Department of Electronics, 30-059 Krakow (Poland); Kucewicz, W., E-mail: kucewicz@agh.edu.pl [AGH University of Science and Technology, Faculty of Electrical Engineering, Automatics, Computer Science and Electronics, Department of Electronics, 30-059 Krakow (Poland); Mik, L.; Sapor, M. [AGH University of Science and Technology, Faculty of Electrical Engineering, Automatics, Computer Science and Electronics, Department of Electronics, 30-059 Krakow (Poland)

2013-08-01

Gain of the silicon photomultiplier is strongly dependent on the value of bias voltage and temperature. This paper proposes a method for gain stabilization just by compensation of temperature fluctuations by bias correction. It has been confirmed that this approach gives good results and the gain can be kept very stable.

Development of 2D-ACAR apparatus using position-sensitive photomultiplier tubes

Energy Technology Data Exchange (ETDEWEB)

Nagai, Yasuyoshi; Saito, Haruo; Iwata, Tetsuya; Nagashima, Yasuyuki; Hyodo, Toshio [Tokyo Univ. (Japan). Coll. of Arts and Sciences; Uchida, Hiroshi; Omura, Tomohide

1997-03-01

A new two-dimensional angular correlation of annihilation radiation apparatus is described. Position-sensitive photomultiplier tubes coupled with two-dimensional arrays of small BGO scintillator blocks make simple and compact position-sensitive {gamma}-ray detectors. With a sample-detector distance of 5m, an angular resolution of 1.1 mrad FWHM and a coincidence count rate of {approx}2.4 c.p.s. per mCi are obtained. Its performance is demonstrated by the result of a test measurement for KI crystal in which non-localized positronium exists at low temperatures. (author)

Windows for Intel Macs

CERN Document Server

Ogasawara, Todd

2008-01-01

Even the most devoted Mac OS X user may need to use Windows XP, or may just be curious about XP and its applications. This Short Cut is a concise guide for OS X users who need to quickly get comfortable and become productive with Windows XP basics on their Macs. It covers: Security Networking ApplicationsMac users can easily install and use Windows thanks to Boot Camp and Parallels Desktop for Mac. Boot Camp lets an Intel-based Mac install and boot Windows XP on its own hard drive partition. Parallels Desktop for Mac uses virtualization technology to run Windows XP (or other operating systems

Süryaniler’in Tarihi ve Sosyolojik Yapısı

OpenAIRE

Ürek, Melki

2014-01-01

Bu makalede, Süryanilerin tarihi süreçleri ve sosyolojik yapıları ele alın-mıştır. Süryaniler yüzyıllar boyunca oldukça kaotik bir cooğrafyada yaşa-mışlarddır. Bu nedenle, dini, politik ve ideolojik açıdan pek çok farklı pa-radigmanın etkisi altında kalmışlardır. Bu olumsuz etki Süryanileri tarihi ve teolojik açıdan hatalı tanımlamalar ve yanlış isimlendirmeler gibi so-runlarla yüz yüze bırakmıştır. Ancak son zamanlarda üretilen akademik ve objektif çalışmalarla, Süryani liderlerin kendilerin...

Studies on a silicon-photomultiplier-based camera for Imaging Atmospheric Cherenkov Telescopes

Science.gov (United States)

Arcaro, C.; Corti, D.; De Angelis, A.; Doro, M.; Manea, C.; Mariotti, M.; Rando, R.; Reichardt, I.; Tescaro, D.

2017-12-01

Imaging Atmospheric Cherenkov Telescopes (IACTs) represent a class of instruments which are dedicated to the ground-based observation of cosmic VHE gamma ray emission based on the detection of the Cherenkov radiation produced in the interaction of gamma rays with the Earth atmosphere. One of the key elements of such instruments is a pixelized focal-plane camera consisting of photodetectors. To date, photomultiplier tubes (PMTs) have been the common choice given their high photon detection efficiency (PDE) and fast time response. Recently, silicon photomultipliers (SiPMs) are emerging as an alternative. This rapidly evolving technology has strong potential to become superior to that based on PMTs in terms of PDE, which would further improve the sensitivity of IACTs, and see a price reduction per square millimeter of detector area. We are working to develop a SiPM-based module for the focal-plane cameras of the MAGIC telescopes to probe this technology for IACTs with large focal plane cameras of an area of few square meters. We will describe the solutions we are exploring in order to balance a competitive performance with a minimal impact on the overall MAGIC camera design using ray tracing simulations. We further present a comparative study of the overall light throughput based on Monte Carlo simulations and considering the properties of the major hardware elements of an IACT.

Van Otlu Peynirinin Yapılışı ve Mikrobiyolojik, Fiziksel ve Kimyasal Nitelikleri

Directory of Open Access Journals (Sweden)

Ahmet Kurt

2015-02-01

Full Text Available Bu araştırmada 10 adet taze Van Otlu peyniri örneklerine; mikrobiyolojik, fiziksel ve kimyasal analizler uygulanmıştır. Peynir teknolojisinde, sağlık, teknik ve ekonomik yönden önemli olan toplam koliform, süt asidi, lipolitik ve proteolitik mikroorganizmalarla maya ve küflerin sayısal değerleri yanında rutubet, yağ, yağsız kurumadde, kurumaddede yağ, protein, suda eriyen protein, kül, tuz, saf kül, kurumaddede tuz ve % asitlik oranları, peynir örneklerinde ayrı ayrı saptanmıştır. Elde edilen sonuçlara göre peynir yapımı çok dağınık ve ilkel karakter arz etmektedir. Peynirlerin yapımındaki farklı uygulamalar, teknik bilgi ve yöntem noksanlığı yüzünden, gerek mikrobiyolojik analiz ve gerekse fiziksel ve kimyasal analiz sonuçları örnekten örneğe önemli fraklılıklar göstermiştir. Peynir örneklerinde saptanan Koliform organizma sayıları, hem sağlık yönünden hem de peynirlerin olgunlaşmalarında sorunlara neden olabilecek düzeydedir.

Windows XP ends its life at CERN – register for Windows 7 training!

CERN Multimedia

Michał Kwiatek (IT-OIS)

2012-01-01

Windows XP has been around for over 10 years and it is now time to move on. At CERN, general support for Windows XP will end in December 2012, and before this date users are requested to schedule a migration to the next version of Windows – Windows 7.   Windows 7 is already well established at CERN – it is used by a large majority of users. In fact, there was a considerable user demand even before its official release in October 2009 and its adoption has been smooth. Users praise Windows 7 for its improved stability and a clear advantage on laptops is a much more efficient implementation of offline files. The migration to Windows 7 involves a reinstallation of the operating system. Files stored in user home folders on DFS will be immediately available after the reinstallation. Applications will be upgraded to more recent versions and in certain cases, an application may even be replaced by another application providing the same functionality. Microsoft Office suite is a good ...

Thermal bridges of modern windows

DEFF Research Database (Denmark)

Hansen, Ernst Jan de Place; Møller, Eva B.; Nielsen, Anker

2013-01-01

if the window has an U-factor of 1 W/(m2·K) or lower. This paper describes the development of modern, energy efficient Danish windows with reduced thermal bridges. It focuses on materials, geometry, and sealing of window panes based on a literature review. Examples of modern windows are presented. Experience...... been an important driver for the development of new window solutions in Denmark, increasing the inner-surface temperature at the sealing of window panes. However, it will not stop complaints fromconsumers, as this temperature is calculated under standardized conditions. Increasing requirements...

Performance of 8- and 12-dynode stage multianode photo-multipliers

Energy Technology Data Exchange (ETDEWEB)

Bibby, J.H. [University of Oxford, Oxford (United Kingdom); Buckley, A. [Cavendish Laboratory, University of Cambridge, Cambridge (United Kingdom); Chamonal, R.J.U. [University of Edinburgh, Edinburgh (United Kingdom)]. E-mail: chamonal@ph.ed.ac.uk; Easo, S. [CCLRC, Rutherford Aplleton Laboratory, Chilton, Didcot, Oxfordshire (United Kingdom); Eisenhardt, S. [University of Edinburgh, Edinburgh (United Kingdom); Gibson, V. [Cavendish Laboratory, University of Cambridge, Cambridge (United Kingdom); Harnew, N. [University of Oxford, Oxford (United Kingdom); Muheim, F. [University of Edinburgh, Edinburgh (United Kingdom); Howard, A. [Imperial College, London (United Kingdom); Lawrence, J. [University of Edinburgh, Edinburgh (United Kingdom); Pickford, A. [University of Glasgow, Glasgow (United Kingdom); Plackett, R. [Imperial College, London (United Kingdom); Price, D.R. [Imperial College, London (United Kingdom); Rademacker, J. [University of Oxford, Oxford (United Kingdom); Smale, N. [University of Oxford, Oxford (United Kingdom); Soler, F.J.P. [University of Glasgow, Glasgow (United Kingdom); CCLRC, Rutherford Aplleton Laboratory, Chilton, Didcot, Oxfordshire (United Kingdom); Somerville, L. [University of Oxford, Oxford (United Kingdom); Storey, J. [Cavendish Laboratory, University of Cambridge, Cambridge (United Kingdom); Websdale, D. [Imperial College, London (United Kingdom); Wotton, S. [Cavendish Laboratory, University of Cambridge, Cambridge (United Kingdom)

2006-11-01

We report on studies of 64-channel Multianode Photo-Multiplier Tubes (MaPMTs) as photo-detectors for Ring Imaging CHerenkov (RICH) counters. The newly available 8-dynode stage MaPMT was tested in particle beams at CERN. The MaPMT signals were read out directly with the Beetle1.2 chip which was designed for the LHCb environment and operates at 40MHz. The photon yield and signal losses were determined for a cluster of 3x3 close-packed MaPMTs. The performance of the 8-dynode stage MaPMT was compared to that of the 12-dynode stage MaPMT which has a larger intrinsic gain.

A study on light collection of small scintillating crystals

CERN Document Server

Vittori, F; Malatesta, T; Puertolas, D

2000-01-01

Measurements are described concerning the light collection efficiency of YAP:Ce and CsI(Tl) crystals pillars with thicknesses ranging between 3 and 28 mm and cross-sections of 0.6 x 0.6 and 1 x 1 mm sup 2. These measurements have shown that the light collection is strongly dependent on the length of the pillar rather than on its cross-sectional area. A Monte Carlo code has been developed in order to evaluate the light collection efficiency as a function of the pillar geometry and surface treatment. Particular attention has been paid to the light transition through the crystal-photocathode window interface. The possibility to improve light detection by using a new photon detector provided with a YAP photocathode window has been verified.

Method and device for demounting in a radiation detector a photomultiplier tube

International Nuclear Information System (INIS)

Persyk, D.E.; Stoub, E.W.

1986-01-01

A device is described for demounting in a radiation detector a photomultiplier tube which is bonded with its scintillation crystal assembly by means of an elastic light transparent adhesive, comprising: (a) a music wire of about 0.01 to 0.03 inch diameter which forms a noose between its wire ends, the noose being provided for being placed aroung the bond; and (b) twisting means connected with both wire ends for twisting them such that the noose becomes smaller thereby sharing the bond

Tokamak physics experiment: Diagnostic windows study

International Nuclear Information System (INIS)

Merrigan, M.; Wurden, G.A.

1995-11-01

We detail the study of diagnostic windows and window thermal stress remediation in the long-pulse, high-power Tokamak Physics Experiment (TPX) operation. The operating environment of the TPX diagnostic windows is reviewed, thermal loads on the windows estimated, and cooling requirements for the windows considered. Applicable window-cooling technology from other fields is reviewed and its application to the TPX windows considered. Methods for TPX window thermal conditioning are recommended, with some discussion of potential implementation problems provided. Recommendations for further research and development work to ensure performance of windows in the TPX system are presented

Mastering Windows 7 Deployment

CERN Document Server

Finn, Aidan; van Surksum, Kenneth

2011-01-01

Get professional-level instruction on Windows 7 deployment tools Enterprise-level operating system deployment is challenging and requires knowledge of specific tools. It is expected that Windows 7 will be extensively deployed in businesses worldwide. This comprehensive Sybex guide provides thorough coverage of the Microsoft deployment tools that were specifically created for Windows 7, preparing system administrators, MIS professionals, and corporate programmers to tackle the task effectively.Companies worldwide are expected to deploy Windows 7 as their enterprise operating system; system admi

Evaluation of the performance of the YAP-(S)PET scanner and its application in neuroscience

International Nuclear Information System (INIS)

Belcari, Nicola; Guerra, Alberto Del; Bartoli, Antonietta; Bianchi, Daniele; Lazzarotti, Marco; Sensi, Luca; Menichetti, Luca; Lecchi, Michela; Erba, Paola A.; Mariani, Giuliano; Corsini, Giovanni U.; Sgado, Paola

2007-01-01

This paper presents the performance evaluation of the small animal scanner YAP-(S)PET, both in PET and SPECT modalities following preliminary NEMA standards for small animal PET. Data are taken with a new version of the scanner that is installed at the IFC-CNR in Pisa (Italy) within the framework of the Center of Excellence AmbiSEN of the University of Pisa. This paper also reports some preliminary SPECT applications in neuroscience using 123 I-FP-CIT (DaTSCAN)

Handbook on Windows and Energy

DEFF Research Database (Denmark)

Thomsen, Kirsten Engelund; Schultz, Jørgen Munthe; Svendsen, Sv Aa Højgaard

The handbook on windows and energy is a general description of windows with the main focus put on the energy performance. Common window products are described by commonly used nomenclature, description of frame and sash conctructions and description of commonly used glazing types.The energy...... transmission through windows is described in detail including radiation, convection and conduction as well as solar transmittance of window glazing. The most used terms related to characterization of window energy performance are defined and calculation methods according to international standards...... flow and detailed calculation of light and solar transmittance is given.Different measurement techniques for characterization of window heat loss coefficient and total solar energy transmittance is described and references to interantional standards are given.Finally, the handbook includes...

Characterization studies of Silicon Photomultipliers and crystals matrices for a novel time of flight PET detector

CERN Document Server

Auffray, Etiennette; Cortinovis, Daniele; Doroud, Katayoun; Garutti, Erika; Lecoq, Paul; Liu, Zheng; Martinez, Rosana; Paganoni, Marco; Pizzichemi, Marco; Silenzi, Alessandro; Xu, Chen; Zvolský, Milan

2015-01-01

This paper describes the characterization of crystal matrices and silicon photomultiplier arrays for a novel Positron Emission Tomography (PET) detector, namely the external plate of the EndoTOFPET-US system. The EndoTOFPET-US collaboration aims to integrate Time-Of-Flight PET with ultrasound endoscopy in a novel multimodal device, capable to support the development of new biomarkers for prostate and pancreatic tumors. The detector consists in two parts: a PET head mounted on an ultrasound probe and an external PET plate. The challenging goal of 1 mm spatial resolution for the PET image requires a detector with small crystal size, and therefore high channel density: 4096 LYSO crystals individually readout by Silicon Photomultipliers (SiPM) make up the external plate. The quality and properties of these components must be assessed before the assembly. The dark count rate, gain, breakdown voltage and correlated noise of the SiPMs are measured, while the LYSO crystals are evaluated in terms of light yield and en...

Analysis of inconsistent source sampling in monte carlo weight-window variance reduction methods

Directory of Open Access Journals (Sweden)

David P. Griesheimer

2017-09-01

Full Text Available The application of Monte Carlo (MC to large-scale fixed-source problems has recently become possible with new hybrid methods that automate generation of parameters for variance reduction techniques. Two common variance reduction techniques, weight windows and source biasing, have been automated and popularized by the consistent adjoint-driven importance sampling (CADIS method. This method uses the adjoint solution from an inexpensive deterministic calculation to define a consistent set of weight windows and source particles for a subsequent MC calculation. One of the motivations for source consistency is to avoid the splitting or rouletting of particles at birth, which requires computational resources. However, it is not always possible or desirable to implement such consistency, which results in inconsistent source biasing. This paper develops an original framework that mathematically expresses the coupling of the weight window and source biasing techniques, allowing the authors to explore the impact of inconsistent source sampling on the variance of MC results. A numerical experiment supports this new framework and suggests that certain classes of problems may be relatively insensitive to inconsistent source sampling schemes with moderate levels of splitting and rouletting.

Kalman Filtered Bio Heat Transfer Model Based Self-adaptive Hybrid Magnetic Resonance Thermometry.

Science.gov (United States)

Zhang, Yuxin; Chen, Shuo; Deng, Kexin; Chen, Bingyao; Wei, Xing; Yang, Jiafei; Wang, Shi; Ying, Kui

2017-01-01

To develop a self-adaptive and fast thermometry method by combining the original hybrid magnetic resonance thermometry method and the bio heat transfer equation (BHTE) model. The proposed Kalman filtered Bio Heat Transfer Model Based Self-adaptive Hybrid Magnetic Resonance Thermometry, abbreviated as KalBHT hybrid method, introduced the BHTE model to synthesize a window on the regularization term of the hybrid algorithm, which leads to a self-adaptive regularization both spatially and temporally with change of temperature. Further, to decrease the sensitivity to accuracy of the BHTE model, Kalman filter is utilized to update the window at each iteration time. To investigate the effect of the proposed model, computer heating simulation, phantom microwave heating experiment and dynamic in-vivo model validation of liver and thoracic tumor were conducted in this study. The heating simulation indicates that the KalBHT hybrid algorithm achieves more accurate results without adjusting λ to a proper value in comparison to the hybrid algorithm. The results of the phantom heating experiment illustrate that the proposed model is able to follow temperature changes in the presence of motion and the temperature estimated also shows less noise in the background and surrounding the hot spot. The dynamic in-vivo model validation with heating simulation demonstrates that the proposed model has a higher convergence rate, more robustness to susceptibility problem surrounding the hot spot and more accuracy of temperature estimation. In the healthy liver experiment with heating simulation, the RMSE of the hot spot of the proposed model is reduced to about 50% compared to the RMSE of the original hybrid model and the convergence time becomes only about one fifth of the hybrid model. The proposed model is able to improve the accuracy of the original hybrid algorithm and accelerate the convergence rate of MR temperature estimation.

Lower HVAC Costs | Efficient Windows Collaborative

Science.gov (United States)

Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

Increased Light & View | Efficient Windows Collaborative

Science.gov (United States)

Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

Condensation Resistance (CR) | Efficient Windows Collaborative

Science.gov (United States)

Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

Fact Sheets & Publications | Efficient Windows Collaborative

Science.gov (United States)

Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

State Fact Sheets | Efficient Windows Collaborative

Science.gov (United States)

Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

State Code Guides | Efficient Windows Collaborative

Science.gov (United States)

Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

Low Conductance Spacers | Efficient Windows Collaborative

Science.gov (United States)

Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

Energy & Cost Savings | Efficient Windows Collaborative

Science.gov (United States)

Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

Provide Natural Light | Efficient Windows Collaborative

Science.gov (United States)

Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

Provide Fresh Air | Efficient Windows Collaborative

Science.gov (United States)

Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

Air Leakage (AL) | Efficient Windows Collaborative

Science.gov (United States)

Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

Windows 95 Beslutningsguide

DEFF Research Database (Denmark)

Sørensen, Jens Otto

1996-01-01

Mange virksomheder der bruger pc'er står netop nu over for valget: Skal vi fortsætte med DOS/Windows 3.x som operativsystem, eller skal vi skifte til efterfølgeren Windows 95? Skal vi/kan vi skifte successivt, eller skal det være en "alt eller intet beslutning". Hvornår er det rigtige tidspunkt...... at skifte? Denne artikel vil forsøge at give en baggrundsviden om Windows 95, der kan hjælpe virksomhederne igennem denne beslutningsfase....

Gabor windows supported on [-1,1] and compactly supported dual windows

DEFF Research Database (Denmark)

Christensen, Ole; Kim, H. O.; Rae Young, Kim

2010-01-01

window. More precisely, we show that if b window supported on [-N, N]. Under the additional assumption that g is continuous and only has a finite number of zeros on inverted left perpendicular-1, 1inverted right perpendicular, we...... characterize the frame property of {E(mb)T(n)g}(m,n is an element of Z). As a consequence we obtain easily verifiable criteria for a function g to generate a Gabor frame with a dual window having compact support of prescribed size....

Designing for Windows 8 fundamentals of great design in Windows Store apps

CERN Document Server

Schooley, Brent

2013-01-01

Designing for Windows 8 is a fast-paced, 150-page primer on the key design concepts you need to create successful Windows 8 apps. This book will help you design a user interface that is both delightful and effective, feels 'right' to your users, and encapsulates a great Windows 8 experience. In this book, you will: Meet the building blocks of solid Windows 8 UI design in a well-designed sample app. Learn how to incorporate key design elements into your apps, such as the app bar, charms and subtle animations from the animation library. Find out how to deliver the core experience that your users

Multiple Charging Station Location-Routing Problem with Time Window of Electric Vehicle

Directory of Open Access Journals (Sweden)

Wang Li-ying

2015-11-01

Full Text Available This paper presents the electric vehicle (EV multiple charging station location-routing problem with time window to optimize the routing plan of capacitated EVs and the strategy of charging stations. In particular, the strategy of charging stations includes both infrastructure-type selection and station location decisions. The problem accounts for two critical constraints in logistic practice: the vehicle loading capacity and the customer time windows. A hybrid heuristic that incorporates an adaptive variable neighborhood search (AVNS with the tabu search algorithm for intensification was developed to address the problem. The specialized neighborhood structures and the selection methods of charging station used in the shaking step of AVNS were proposed. In contrast to the commercial solver CPLEX, experimental results on small-scale test instances demonstrate that the algorithm can find nearly optimal solutions on small-scale instances. The results on large-scale instances also show the effectiveness of the algorithm.

Türkiye Türkçesinde -ma Ekinin Yapım Eki Olarak İşlevleri / Functions of the Derivative Suffix -ma in Turkey Turkish

Directory of Open Access Journals (Sweden)

Nesrin Bayraktar Erten

2017-12-01

Full Text Available Abstract Functions of the suffix -ma suffix can be classified under three groups in Turkey Turkish. This suffix produces adjectives that are related with root meanings like dönme dolap, sallama çay, gömme dolap, and adjectives like bodoslama atla, silme doldur etc. Besides these functions, it produces permanent nouns like gözleme, sarma, dolma, dondurma, kuzukapama, sürme, etc. This study investigates the suffix -ma as a derivational form and its functions have been classified. The study also evaluates the frequency with which it is used to coin permanent nouns and adjectives.   Öz -ma ekinin Türkiye Türkçesinde işlevlerini başlıca üç grupta toplamak mümkündür. -ma eki ile bir yandan dönme dolap, sallama çay, gömme dolap gibi örneklerde eklendiği eylem tabanıyla ilişkili sıfatlar ve bodoslama atla, silme doldur gibi zarflar yapılırken, öte yandan da gözleme, sarma, dolma, dondurma, kuzukapama, sürme örneklerinde görüldüğü gibi kalıcı adlar yapılmıştır. Kalıcı adlar içinde yemek adları, oldukça önemli bir yer tutmaktadır. Bu çalışmada -ma eki, bir yapım eki olarak değerlendirilecek ve örnekler çerçevesinde tasnif edilerek kalıcı ad ve sıfat yapımında kullanıldığı yerlerdeki sıklık ele alınacaktır.

Emerging role of Hippo signalling in pancreatic biology: YAP re-expression and plausible link to islet cell apoptosis and replication.

Science.gov (United States)

Sharma, Anjana; Yerra, Veera Ganesh; Kumar, Ashutosh

2017-02-01

Diabetes mellitus is an ailment that develops when the functional capacity of the pancreas does not meet the metabolic requirements of the whole body, either due to insulin insufficiency or resistance to insulin action. Current therapies that control glycaemia are limited by their unwanted effects or their inability to prevent the development of long-term complications. Regeneration and replacement of beta cell therapies are shaping the goals of future management of diabetes. The Hippo pathway, first discovered in Drosophila melanogaster, plays a vital role in controlling the organ size. Nuclear recruitment of YAP/TAZ (Yes-associated protein/transcriptional co-activator with PDZ-binding motif), a mammalian analogue of Yorkie protein found in Drosophila, activates cell proliferation and inhibits apoptosis. YAP was found to regulate early pancreatic development followed by downregulation during Ngn3-specific endocrine lineage maturation corresponding to their mitotic quiescence. Recent evidences have shown that optimum modulation of upstream kinases in the Hippo signalling pathway may lead to apoptosis inhibition and renewal of progenitor as well as stem cells in case of tissue or cell injury. This article reviews the evidences linking the role of various components of the Hippo pathway to pancreatic regeneration. In particular, the focus is on the beneficial role of induced YAP expression and its nuclear distribution on apoptosis and replication of adult pancreatic β islets. This approach may be of immense significance towards our fight against diabetes; thus, more insightful research is warranted in the area of Hippo signalling pathway and its involvement in pancreatic regeneration. Copyright © 2016 Elsevier B.V. and Société Française de Biochimie et Biologie Moléculaire (SFBBM). All rights reserved.

Study of silicon photomultipliers fast amplifier and thermoregulation

International Nuclear Information System (INIS)

D'antone, I.; Fabbri, L.; Foschi, E.; Guandalini, C.; Laurenti, G.; Lax, I.; Levi, G.; Quadrani, L.; Sbarra, Ca.; Sbarra, Cr.; Villa, M.; Zoccoli, A.; Zuffa, M.

2011-01-01

The silicon photomultipliers (SiPM) are adopted in various physical applications, from medical physics to astrophysics, for their advantages in terms of cost and weight with respect to traditional photo detectors. Their low bias voltage supply (about 30 V), hardiness and resistance to magnetic field are ideal characteristics for space application. In the frame of INFN-Irst collaboration, some of them have been developed and produced at FBK (Trento-Italy), and have been characterized in the INFN laboratories of Bologna (DaSiPM2 collaboration). The SiPM can be used in conjunction with fibres and counters in high energy physics experiments. To exploit the SiPM time resolution, a fast amplifier has been studied. The SiPM gain depends critically on temperature and a thermal stabilization is also necessary. The use of a thermoelectric cooler module based on a Peltier cell has been investigated, and the results are shown.

TRNSYS HYBRID wind diesel PV simulator

Energy Technology Data Exchange (ETDEWEB)

Quinlan, P.J.A.; Mitchell, J.W.; Klein, S.A.; Beckman, W.A.; Blair, N.J. [Univ. of Wisconsin, Madison, WI (United States)

1996-12-31

The Solar Energy Laboratory (SEL) has developed a wind diesel PV hybrid systems simulator, UW-HYBRID 1.0, an application of the TRNSYS 14.2 time-series simulation environment. An AC/DC bus links up to five diesels and wind turbine models, along with PV modules, a battery bank, and an AC/DC converter. Multiple units can be selected. PV system simulations include solar angle and peak power tracking options. Weather data are Typical Meteorological Year data, parametrically generated synthesized data, or external data files. PV performance simulations rely on long-standing SEL-developed algorithms. Loads data are read as scalable time series. Diesel simulations include estimated fuel-use and waste heat output, and are dispatched using a least-cost of fuel strategy. Wind system simulations include varying air density, wind shear and wake effects. Time step duration is user-selectable. UW-HYBRID 1.0 runs in Windows{reg_sign}, with TRNSED providing a customizable user interface. 12 refs., 6 figs.

Study of capillary tracking detectors with position-sensitive photomultiplier readout

International Nuclear Information System (INIS)

Cardini, A.; Cavasinni, V.; Di Girolamo, B.; Dolinsky, S.I.; Flaminio, V.; Golovkin, S.V.; Gorin, A.M.; Medvedkov, A.M.; Pyshev, A.I.; Tyukov, V.E.; Vasilchenko, V.G.; Zymin, K.V.

1995-01-01

Measurements have been carried out on light yield and attenuation length in glass capillaries filled with new liquid scintillators (LS) and compared with analogous measurements made on 0.5 mm diameter plastic fibres Kuraray SCSF-38 and 3HF. It is found that, at a distance of 1 m, the light output in the capillary filled with green LS based on 1-methylnaphthalene doped with a new dye 3M15 is greater by a factor of 2 to 3 than for plastic fibres. A tracking detector consisting of a capillary bundle read out by a 100 channel position-sensitive microchannel plate photomultiplier (2MCP-100) has been built and tested in the laboratory using a cosmic ray trigger. A comparison has been made between the performance of such a detector and that of a similar one, read out by a 96 channel Philips XP1724/A photomultiplier. It was found that a bundle made of 20μm diameter capillaries with a tapered end giving a magnification of 2.56, filled with the new IPN+3M15 liquid scintillator, read out by the 2MCP-100, provides a space resolution of σ=170μm, a two-track resolution of the same value and a hit density of n=1.9/mm for tracks crossing the detector at a distance of 20 cm from the photocathode. If the same detector is read out by the Philips XP1724/A, the space resolution becomes 200μm, the two-track resolution 600μm and the hit density n=1.7/mm. The worse performance in the latter case is caused by the larger crosstalk compared with that of the 2MCP-100 PSPM. The results indicate that a LS-filled capillary detector is a very promising device for fast fibre tracking. (orig.)

The development of a high-resolution scintillating fiber tracker with silicon photomultiplier readout

International Nuclear Information System (INIS)

Roper Yearwood, Gregorio

2013-01-01

In this work I present the design and test results for a novel, modular tracking detector from scintillating fibers which are read out by silicon photomultiplier (SiPM) arrays. The detector modules consist of 0.25 mm thin scintillating fibers which are closely packed in five-layer ribbons. Two ribbons are fixed to both sides of a carbon-fiber composite structure. Custom made SiPM arrays with a photo-detection efficiency of about 50% read out the fibers. Several 860 mm long and 32 mm wide tracker modules were tested in a secondary 12 GeV/c beam at the PS facilities, CERN in November of 2009. During this test a spatial resolution better than 0.05 mm at an average light yield of about 20 photons for a minimum ionizing particle was determined. This work details the characterization of scintillating fibers and silicon photomultipliers of different make and model. It gives an overview of the production of scintillating fiber modules. The behavior of detector modules during the test-beam is analyzed in detail and different options for the front-end electronics are compared. Furthermore, the implementation of the proposed tracking detector from scintillating fibers within the scope of the PERDaix experiment is discussed. The PERDaix detector is a permanent magnet spectrometer with a weight of 40 kg. It consists of 8 tracking detector layers from scintillating fibers, a time-of-flight detector from plastic scintillator bars with silicon photomultiplier readout and a transition radiation detector from an irregular fleece radiator and Xe/CO 2 filled proportional counting tubes. The PERDaix detector was launched with a helium balloon within the scope of the ''Balloon-Experiments for University Students'' (BEXUS) program from Kiruna, Sweden in November 2010. For a few hours PERDaix reached an altitude of 33 km and measured cosmic rays. In May 2011, the PERDaix detector was characterized during a test-beam at the PS-facilities at CERN. This work introduces methods for event

The KFA TierPET: Performance characteristics and measurements

International Nuclear Information System (INIS)

Weber, S.; Herzog, H.; Mueller-Gaertner, H.W.

1996-01-01

We will present first results of the KFA Tier-PET, a positron emission tomograph with flexible geometry dedicated to in vivo studies of small animals. The flexible geometry allows us to change between measurements with high spatial resolution and measurements with increased sensitivity at the cost of resolution. The detectors consist of yttrium aluminum perovskit scintillator arrays which are glued together from 20 x 20 optically isolated crystals, coupled to position sensitive photomultiplier tubes. The fundamental design features concerning crystal dimensions and detector arrangement have been simulated. Based on this data, the definite dimensional outline of the crystals was determined. The YAP:Ce matrix in combination with a position sensitive photomultiplier leads to a detector block with a high spatial resolution. In first measurements a system sensitivity of 1.8 kcps/μCi/ml has been evaluated for a detector-to-detector distance of 16 cm

Windows with improved energy performances

DEFF Research Database (Denmark)

Laustsen, Jacob Birck; Svendsen, Svend

2003-01-01

Heat loss through windows represents a considerable part of the total heat loss from houses. However, apart from providing daylight access and view, windows offer a unique potential for solar gain to be exploited during the heating season. Until now valuation of the energy performance of windows...... has primary focused on the heat loss coefficient, U-value. However, as the U-value, especially for the glazing part, has improved considerably during the last years, the total solar energy transmittance, g-value, has become equally important to the total energy performance of windows. Improved energy...... resulted in a window with a positive net energy gain (in short the Net Gain Window), which means that it contributes to the space heating of the building. All improvements are based on existing technology and manufacturing methods. The results from this work show that the energy performances of windows can...

Beginning Windows 8.1

CERN Document Server

Halsey, Mike

2013-01-01

Windows 8 has been described by Microsoft as its 'boldest' Windows release ever and the 8.1 update enhances the paradigm further. Beginning Windows 8.1 takes you through the new features and helps you get more out of the familiar to reveal the fullest possibilities for this amazing new operating system. You will learn, with non-technical language used throughout, how to get up and running in the new Windows interface, minimize downtime, maximize productivity, and harness the features you never knew existed to take control of your computer and enjoy the peace of mind and excitement that comes w

Tailoring double Fano profiles with plasmon-assisted quantum interference in hybrid exciton-plasmon system

International Nuclear Information System (INIS)

Zhao, Dongxing; Wu, Jiarui; Gu, Ying; Gong, Qihuang

2014-01-01

We propose tailoring of the double Fano profiles via plasmon-assisted quantum interference in a hybrid exciton-plasmon system. Tailoring is performed by the interference between two exciton channels interacting with a common localized surface plasmon. Using an applied field of low intensity, the absorption spectrum of the hybrid system reveals a double Fano lineshape with four peaks. For relatively large field intensity, a broad flat window in the absorption spectrum appears which results from the destructive interference between excitons. Because of strong constructive interference, this window vanishes as intensity is further increased. We have designed a nanometer bandpass optical filter for visible light based on tailoring of the optical spectrum. This study provides a platform for quantum interference that may have potential applications in ultracompact tunable quantum devices.

Visual merchandising window display

Directory of Open Access Journals (Sweden)

Opris (Cas. Stanila M.

2013-12-01

Full Text Available Window display plays a major part in the selling strategies; it does not only include the simple display of goods, nowadays it is a form of art, also having the purpose of sustaining the brand image. This article wants to reveal the tools that are essential in creating a fabulous window display. Being a window designer is not an easy job, you have to always think ahead trends, to have a sense of colour, to know how to use light to attract customers in the store after only one glance at the window. The big store window displays are theatre scenes: with expensive backgrounds, special effects and high fashion mannequins. The final role of the displays is to convince customers to enter the store and trigger the purchasing act which is the final goal of the retail activity.

Automated installation for several photomultiplier photocathode activation by means of one vacuum facility

International Nuclear Information System (INIS)

Beschastnov, P.M.; Peryshkin, A.I.; Pyata, E.Eh.; Usov, Yu.V.

1989-01-01

An automated installation for simultaneous activation of up to four photocathodes of several photomultipliers by means of one vacuum station with the common furnace is described. Production technology of producing multialkaline photocathode makes up the basis for creating automated technology. The installation is produced on the base of the R110B industrial station and the Electronica-60 microcomputer. Software written in FORTRAN providing for control over all process stages is developed. 6 refs.; 2 figs

Large-aperture hybrid photo-detector

International Nuclear Information System (INIS)

Kawai, Y.; Nakayama, H.; Kusaka, A.; Kakuno, H.; Abe, T.; Iwasaki, M.; Aihara, H.; Tanaka, M.; Shiozawa, M.; Kyushima, H.; Suyama, M.

2007-01-01

We have developed the first complete large-aperture (13-inch diameter) hybrid photo-detector (HPD). The withstanding voltage problem has been overcome and we were able to attain an HPD operating voltage of +20 kV. Adoption of our newly developed backside illumination avalanche diode (AD) was also critical in successfully countering the additional problem of an increase in AD leakage after the activation process. We observed single photon signal timing jitter of under 450 ps in FWHM, electron transit time of ∼12 ns, and clear pulse height separation up to several photoelectron peaks, all greatly superior to the performance of any conventional large-aperture photomultiplier tubes (PMTs). In addition, our HPD has a much simpler structure than conventional large-aperture PMTs, which simplifies mass production and lowers manufacturing cost. We believe that these attributes position our HPD as the most suitable photo-detector for the next generation mega-ton class water-Cherenkov detector, which is expected to be more than 20x larger than the Super-Kamiokande (SK) detector

A Hybrid Genetic Algorithm for the Multiple Crossdocks Problem

Directory of Open Access Journals (Sweden)

Zhaowei Miao

2012-01-01

Full Text Available We study a multiple crossdocks problem with supplier and customer time windows, where any violation of time windows will incur a penalty cost and the flows through the crossdock are constrained by fixed transportation schedules and crossdock capacities. We prove this problem to be NP-hard in the strong sense and therefore focus on developing efficient heuristics. Based on the problem structure, we propose a hybrid genetic algorithm (HGA integrating greedy technique and variable neighborhood search method to solve the problem. Extensive experiments under different scenarios were conducted, and results show that HGA outperforms CPLEX solver, providing solutions in realistic timescales.

Windows 7 is supported at CERN

CERN Multimedia

IT Department

2010-01-01

The new version of the Windows operating system - Windows 7 - is now officially supported at CERN. Windows 7 32-bit is now the default operating system for the new computers at CERN. What’s new in Windows 7 Users of Windows XP will find many new features and options. Users of Windows Vista will feel very familiar with one major difference: higher performance and better responsiveness of the operating system. Other enhancements include: refined Aero desktop that makes it easier to navigate between your different application windows; new snapping windows that allows user to resize a window simply by dragging it to the edge of the screen and “pin” that allows grouping and arranging often accessed applications on the taskbar. Windows 7 introduces the new concept of libraries – containers for user files that have links to different local or network folders. By default, users can see four libraries: Documents, Music, Pictures and Videos. These libraries point to the cor...

The upgrade of the CMS hadron calorimeter with silicon photomultipliers

CERN Document Server

Strobbe, N

2017-01-01

The upgrade of the hadron calorimeter of the CMS experiment at the CERN Large Hadron Collider is currently underway. The endcap sections will be upgraded in the winter of 2016–2017 and the barrel sections during the second LHC long shutdown in 2019. The existing photosensors will be replaced with about 16 000 new silicon photomultipliers (SiPMs), resulting in the first large installation of SiPMs in a radiation environment. All associated front-end electronics will also be upgraded. This paper discusses the motivation for the upgrade and provides a description 17 of the new system, including the SiPMs with associated control electronics and the front-end readout cards.

Maddenin tanecikli yapısının mikro ve makro boyutta anlaşılmasının sağlanması [Aiding comprehension of the particulate of matter at the micro and macro levels

Directory of Open Access Journals (Sweden)

Seda OKUMUŞ

2014-04-01

Full Text Available Bu araştırmada deneyler ve makro gösterim ile maddenin tanecikli yapısının anlaşılması sağlanmaya çalışılmıştır. Araştırmada tek denekli deneysel yöntem kullanılmıştır. Araştırmanın örneklemini Fen Bilgisi Öğretmenliği birinci sınıfında öğrenim gören 48 öğrenci oluşturmaktadır. Araştırmada veri toplama aracı olarak Maddenin Tanecikli Yapısı Testleri (MTYT kullanılmıştır. Testler açık uçlu sorulardan oluşmaktadır. Uygulama sürecinde araştırmanın amacını gerçekleştirmek üzere iki deney yapılmıştır. Deneylerden önce MTYT uygulanmış ve öğrencilerin deneyle ilgili ön bilgileri alınmıştır. Ardından deneyler yapılmış ve deneylerden sonra MTYT tekrar uygulanmış ve öğrencilerin tanecikli yapıyla ilgili anlamaları belirlenmiştir. Ayrıca birinci deney için deneyin ardından öğrencilerin tanecikli yapıyı anlamaları amacıyla makro boyutta gösterim yapılmış ve bu gösterimden sonra tekrar MTYT uygulanmıştır. Araştırmadan elde edilen bulgular, öğrencilerin ilk durumda kavramsal yanlış anlamalarının uygulama sonunda azaldığını göstermektedir. Ancak bazı noktalarda öğrencilerin sahip oldukları yanlış anlamaları devam ettirdikleri görülmüştür.

GA microwave window development

International Nuclear Information System (INIS)

Moeller, C.P.; Kasugai, A.; Sakamoto, K.; Takahashi, K.

1994-10-01

The GA prototype distributed window was tested in a 32 mm diam. waveguide system at a power density suitable for a MW gyrotron, using the JAERI/Toshiba 110 GHz long pulse internal converter gyrotron in the JAERI test stand. The presence of the untilted distributed window had no adverse effect on the gyrotron operation. A pulse length of 10 times the calculated thermal equilibrium time (1/e time) of 30 msec was reached, and the window passed at least 750 pulses greater than 30 msec and 343 pulses greater than 60 msec. Beyond 100 msec, the window calorimetry reached steady state, allowing the window dissipation to be measured in a single pulse. The measured loss of 4.0% agrees both with the estimated loss, on which the stress calculations are based, and with the attenuation measured at low power in the HE 11 mode. After the end of the tests, the window was examined; no evidence of arcing air coating was found in the part of the window directly illuminated by the microwaves, although there was discoloration in a recess containing an optical diagnostic which outgassed, causing a local discharge to occur in that recess. Finally, there was no failure of the metal-sapphire joints during a total operating time of 50 seconds consisting of pulses longer than 30 msec

Music@Microsoft.Windows: Composing Ambience

Science.gov (United States)

Rickert, Thomas

2010-01-01

It is well known, of course, that all Windows versions except for 3.1 have a brief (four to six second) piece of music indicating that Windows is booted and ready for use. While the music may indicate Windows has booted, it bears no immediately discernable relation to the various uses we might actually put Windows to--working, gaming,…

Windows 8 simplified

CERN Document Server

McFedries, Paul

2012-01-01

The easiest way for visual learners to get started with Windows 8 The popular Simplified series makes visual learning easier than ever, and with more than 360,000 copies sold, previous Windows editions are among the bestselling Visual books. This guide goes straight to the point with easy-to-follow, two-page tutorials for each task. With full-color screen shots and step-by-step directions, it gets beginners up and running on the newest version of Windows right away. Learn to work with the new interface and improved Internet Explorer, manage files, share your computer, and much more. Perfect fo

Rails on Windows

CERN Document Server

Hibbs, Curt

2007-01-01

It's no secret that the entire Ruby onRails core team uses OS X as their preferreddevelopment environment. Becauseof this, it is very easy to findauthoritative information on the webabout using Rails on OS X. But the truthis that Windows developers using Railsprobably outnumber those using otherplatforms. A Windows development environmentcan be just as productive asany other platform. This is a guide to developing with Rubyon Rails under Windows. It won't teachyou how to write Ruby on Rails web applications,but it will show you what toolsto use and how to set them up to createa complete Rail

Silicon photo-multiplier radiation hardness tests with a beam controlled neutron source

International Nuclear Information System (INIS)

Angelone, M.; Pillon, M.; Faccini, R.; Pinci, D.; Baldini, W.; Calabrese, R.; Cibinetto, G.; Cotta Ramusino, A.; Malaguti, R.; Pozzati, M.

2010-01-01

Radiation hardness tests were performed at the Frascati Neutron Generator on silicon Photo-Multipliers that were made of semiconductor photon detectors built from a square matrix of avalanche photo-diodes on a silicon substrate. Several samples from different manufacturers have been irradiated, integrating up to 7x10 10 1-MeV-equivalent neutrons per cm 2 . Detector performance was recorded during the neutron irradiation, and a gradual deterioration of their properties began after an integrated fluence of the order of 10 8 1-MeV-equivalent neutrons per cm 2 was reached.

Partially slotted crystals for a high-resolution γ-camera based on a position sensitive photomultiplier

International Nuclear Information System (INIS)

Giokaris, N.; Loudos, G.; Maintas, D.; Karabarbounis, A.; Lembesi, M.; Spanoudaki, V.; Stiliaris, E.; Boukis, S.; Gektin, A.; Pedash, V.; Gayshan, V.

2005-01-01

Partially slotted crystals have been designed and constructed and have been used to evaluate the performance with respect to the spatial resolution of a γ-camera based on a position-sensitive photomultiplier. It is shown that the resolution obtained with such a crystal is only slightly worse than the one obtained with a fully pixelized one whose cost, however, is much higher

Yapılandırılmış Okuma Yönteminin Okuma Hızı, Doğru Okuma ve Sesli Okuma Prozodisi Üzerindeki Etkisi

Directory of Open Access Journals (Sweden)

Hasan Keskin

2014-10-01

Full Text Available Bu çalışma ile yapılandırılmış okuma yönteminin, ilköğretim dördüncü sınıf öğrencilerinin, okuma hızı, doğru okuma ve prozodik okuma becerileri üzerindeki etkisinin araştırılması amaçlanmıştır. Araştırma için 2010-2011 öğretim yılı bahar döneminde Afyonkarahisar merkeze bağlı dört ilköğretim okulundan veri toplanmıştır. Bu okullar arasından basit tesadüfi yöntemle belirlenen bir okuldaki akıcı okuma becerisini yeterince kazanamamış dokuz öğrenci ile oluşturulan grupta 24 ders saati “yapılandırılmış okuma yöntemi” uygulanmıştır. Elde edilen bulgulara göre yapılandırılmış okuma yöntemi öğrencilerin okuma hızı, doğru okuma ve sesli okuma prozodisi becerileri üzerinde etkili olmuştur. Sonuç olarak, yapılandırılmış okuma yönteminin, akıcı okuma becerileri yönünden endişe düzeyinde olan öğrencilerin, bu becerilerini geliştirmede etkili olduğunu söylemek mümkündür.

Windows Home Server users guide

CERN Document Server

Edney, Andrew

2008-01-01

Windows Home Server brings the idea of centralized storage, backup and computer management out of the enterprise and into the home. Windows Home Server is built for people with multiple computers at home and helps to synchronize them, keep them updated, stream media between them, and back them up centrally. Built on a similar foundation as the Microsoft server operating products, it's essentially Small Business Server for the home.This book details how to install, configure, and use Windows Home Server and explains how to connect to and manage different clients such as Windows XP, Windows Vist

Teach yourself visually Windows 10

CERN Document Server

McFedries, Paul

2015-01-01

Learn Windows 10 visually with step-by-step instructions Teach Yourself VISUALLY Windows 10 is the visual learner's guide to the latest Windows upgrade. Completely updated to cover all the latest features, this book walks you step-by-step through over 150 essential Windows tasks. Using full color screen shots and clear instruction, you'll learn your way around the interface, set up user accounts, play media files, download photos from your camera, go online, set up email, and much more. You'll even learn how to customize Windows 10 to suit the way you work best, troubleshoot and repair common

Windows registry forensics advanced digital forensic analysis of the Windows registry

CERN Document Server

Carvey, Harlan

2011-01-01

Harlan Carvey brings readers an advanced book on Windows Registry - the most difficult part of Windows to analyze in forensics! Windows Registry Forensics provides the background of the Registry to help develop an understanding of the binary structure of Registry hive files. Approaches to live response and analysis are included, and tools and techniques for postmortem analysis are discussed at length. Tools and techniques will be presented that take the analyst beyond the current use of viewers and into real analysis of data contained in the Registry. This book also has a DVD containing tools, instructions and videos.

Hybrid Reality Lab Capabilities - Video 2

Science.gov (United States)

Delgado, Francisco J.; Noyes, Matthew

2016-01-01

Our Hybrid Reality and Advanced Operations Lab is developing incredibly realistic and immersive systems that could be used to provide training, support engineering analysis, and augment data collection for various human performance metrics at NASA. To get a better understanding of what Hybrid Reality is, let's go through the two most commonly known types of immersive realities: Virtual Reality, and Augmented Reality. Virtual Reality creates immersive scenes that are completely made up of digital information. This technology has been used to train astronauts at NASA, used during teleoperation of remote assets (arms, rovers, robots, etc.) and other activities. One challenge with Virtual Reality is that if you are using it for real time-applications (like landing an airplane) then the information used to create the virtual scenes can be old (i.e. visualized long after physical objects moved in the scene) and not accurate enough to land the airplane safely. This is where Augmented Reality comes in. Augmented Reality takes real-time environment information (from a camera, or see through window, and places digitally created information into the scene so that it matches with the video/glass information). Augmented Reality enhances real environment information collected with a live sensor or viewport (e.g. camera, window, etc.) with the information-rich visualization provided by Virtual Reality. Hybrid Reality takes Augmented Reality even further, by creating a higher level of immersion where interactivity can take place. Hybrid Reality takes Virtual Reality objects and a trackable, physical representation of those objects, places them in the same coordinate system, and allows people to interact with both objects' representations (virtual and physical) simultaneously. After a short period of adjustment, the individuals begin to interact with all the objects in the scene as if they were real-life objects. The ability to physically touch and interact with digitally created

Silicon photomultipliers in AMIGA muon counters

Energy Technology Data Exchange (ETDEWEB)

Botti, Ana Martina [Institut fuer Kernphysik, Karlsruher Institut fuer Technologie (Germany); Instituto de Tecnologias en Deteccion y Astroparticulas (ITeDA) (Argentina); Collaboration: Pierre-Auger-Collaboration

2016-07-01

The project AMIGA (Auger Muons and Infill for the Ground Array) aims to extend the energy range at the Pierre Auger Observatory to observe cosmic rays of lower energies (down to ∝10{sup 17} eV) and to study the transition from extragalactic to galactic cosmic rays. AMIGA is compounded by an infill of surface detectors (employing Cherenkov radiation detection in water) and muon counters. The AMIGA muon counters consist of an array of buried modules composed of 64 scintillator bars, a multi-pixel Photo Multiplier Tube (PMT) and the corresponding electronic of acquisition which works along with the surface detector. Currently, ITeDA is evaluating the feasibility of replacing PMTs with silicon photomultipliers (SiPM) without performing any substantial modification in the digital readout nor in the mechanical design. I present calibration results of a prototype module associated to the surface detector Toune of the Pierre Auger Observatory using a SiPM Hamamatsu S1257-100C plugged to the standard AMIGA front-end electronics. In addition, a study concerning gain stability and temperature variation has also been performed and is reported. I finally discuss a comparison between traces measured by both photodetectors (PMT and SiPM) for modules associated to the surface detector Toune.

Study of the radiation damage of silicon photomultipliers

Energy Technology Data Exchange (ETDEWEB)

Nitschke, Michael; Chmill, Valery; Garutti, Erika; Klanner, Robert; Schwandt, Joern [Institute for Experimental Physics, Hamburg University, Luruper Chaussee 149, D-22761 Hamburg (Germany)

2016-07-01

Radiation damage significantly changes the performance of silicon photomultipliers (SiPM). In this work, we first have characterized KETEK SiPMs with a pixel size of 15 x 15 μm{sup 2} using I-V (current-voltage), C/G-V/f (capacitance/impedance-voltage/frequency) and Q-V (charge-voltage) measurements with and without illumination with blue light of 470 nm from an LED. The SiPM parameters determined are DCR (dark count rate), relative PDE (photon detection efficiency), G (Gain), XT (cross-talk), Geiger breakdown characteristics, C{sub pix} (pixel capacitance) and R{sub q} (quenching resistance). Following this first characterization, the SiPMs were irradiated using reactor neutrons with fluences of 10{sup 9}, 10{sup 10}, 10{sup 11}, 5 . 10{sup 11}, and 10{sup 12} n/cm{sup 2}. Afterwards, the same measurements were repeated, and the dependence of the SiPM parameters on neutron fluence was determined. The results are used to optimize the radiation tolerance of SiPMs.

Silicon Photomultiplier Performance in High ELectric Field

Science.gov (United States)

Montoya, J.; Morad, J.

2016-12-01

Roughly 27% of the universe is thought to be composed of dark matter. The Large Underground Xenon (LUX) relies on the emission of light from xenon atoms after a collision with a dark matter particle. After a particle interaction in the detector, two things can happen: the xenon will emit light and charge. The charge (electrons), in the liquid xenon needs to be pulled into the gas section so that it can interact with gas and emit light. This allows LUX to convert a single electron into many photons. This is done by applying a high voltage across the liquid and gas regions, effectively ripping electrons out of the liquid xenon and into the gas. The current device used to detect photons is the photomultiplier tube (PMT). These devices are large and costly. In recent years, a new technology that is capable of detecting single photons has emerged, the silicon photomultiplier (SiPM). These devices are cheaper and smaller than PMTs. Their performance in a high electric fields, such as those found in LUX, are unknown. It is possible that a large electric field could introduce noise on the SiPM signal, drowning the single photon detection capability. My hypothesis is that SiPMs will not observe a significant increase is noise at an electric field of roughly 10kV/cm (an electric field within the range used in detectors like LUX). I plan to test this hypothesis by first rotating the SiPMs with no applied electric field between two metal plates roughly 2 cm apart, providing a control data set. Then using the same angles test the dark counts with the constant electric field applied. Possibly the most important aspect of LUX, is the photon detector because it's what detects the signals. Dark matter is detected in the experiment by looking at the ratio of photons to electrons emitted for a given interaction in the detector. Interactions with a low electron to photon ratio are more like to be dark matter events than those with a high electron to photon ratio. The ability to

Window observers for linear systems

Directory of Open Access Journals (Sweden)

Utkin Vadim

2000-01-01

Full Text Available Given a linear system x ˙ = A x + B u with output y = C x and a window function ω ( t , i.e., ∀ t , ω ( t ∈ {0,1 }, and assuming that the window function is Lebesgue measurable, we refer to the following observer, x ˆ = A x + B u + ω ( t L C ( x − x ˆ as a window observer. The stability issue is treated in this paper. It is proven that for linear time-invariant systems, the window observer can be stabilized by an appropriate design under a very mild condition on the window functions, albeit for linear time-varying system, some regularity of the window functions is required to achieve observer designs with the asymptotic stability. The corresponding design methods are developed. An example is included to illustrate the possible applications

Window Selection Tool | Efficient Windows Collaborative

Science.gov (United States)

Louisville LA Lake Charles LA New Orleans LA Shreveport MA Boston MD Baltimore ME Portland MI Detroit MI Window Selection Tool will take you through a series of design conditions pertaining to your design and

Color Wheel Windows

Science.gov (United States)

Leonard, Stephanie

2012-01-01

In this article, the author describes a painting and drawing lesson which was inspired by the beautiful circular windows found in cathedrals and churches (also known as "rose windows"). This two-week lesson would reinforce both the concept of symmetry and students' understanding of the color wheel. (Contains 1 online resource.)

Silicon photomultiplier arrays for the LHCb scintillating fibre tracker

CERN Multimedia

Girard, Olivier Goran; Kuonen, Axel Kevin; Stramaglia, Maria Elena

2017-01-01

For the LHCb detector upgrade in 2019, a large scale scintillating fibre tracker read out with silicon photomultipliers is under construction. The harsh radiation environment (neutron and ionising radiation), the 40MHz read-out rate of the trigger less system and the large detector surface of 320m2 impose many challenges. We present the results from lab tests with 1MeV electrons and from the SPS test facility at CERN for the mulitchannel SiPM array that combines peak photo-detection efficiency of 48% and extremely low correlated noise. The measurements were performed with detectors irradiated with neutrons up to a fluence of 12*1011 neq/cm2 and single photon detection was maintained. First results of the characterization of the pre-series of 500 detectors delivered by Hamamatsu and irradiation studies on a large sample will be included.

Characterization of silicon photomultipliers and validation of the electrical model

Science.gov (United States)

Peng, Peng; Qiang, Yi; Ross, Steve; Burr, Kent

2018-04-01

This paper introduces a systematic way to measure most features of the silicon photomultipliers (SiPM). We implement an efficient two-laser procedure to measure the recovery time. Avalanche probability was found to play an important role in explaining the right behavior of the SiPM recovery process. Also, we demonstrate how equivalent circuit parameters measured by optical tests can be used in SPICE modeling to predict details of the time constants relevant to the pulse shape. The SiPM properties measured include breakdown voltage, gain, diode capacitor, quench resistor, quench capacitor, dark count rate, photodetection efficiency, cross-talk and after-pulsing probability, and recovery time. We apply these techniques on the SiPMs from two companies: Hamamatsu and SensL.

Ultrafast Readout of Scintillating Fibres Using Upgraded Position-Sensitive Photomultipliers

CERN Multimedia

2002-01-01

% RD-17 \\\\ \\\\To design a high rate topological trigger device for the future DIRAC Experiment at CERN an extensive work is in progress on a scintillating-fibre detector using a position-sensitive photomultiplier. Several detector prototypes with different lengths ($<$~50~cm) of sensitive area have been tested at T7S~PS beam. \\\\ \\\\With 0.5~mm diameter fibres a spatial resolution of $\\sim$125~$\\mu$m was obtained with a detection efficiency higher than 95\\%. The time resolution is $\\sim$600~ps, and the track position is properly digitized in real time (about 10~ns) by multi-channel peak sensing circuit. Based on experimental data simulations were also performed a comparison of different types of front-end electronics for multi-channel readout.

Topological trigger device using scintillating fibers and position-sensitive photomultipliers

Energy Technology Data Exchange (ETDEWEB)

Kuroda, Keiichi; Dufournaud, J; Sillou, D [Laboratoire d' Annecy-le-Vieux de Physique des Particules (LAPP), 74 (France); Agoritsas, V [European Organization for Nuclear Research, Geneva (Switzerland); Bystricky, G; Lehar, F; Lesquen, A de [CEN-Saclay, 91 - Gif-sur-Yvette (France); Giacomich, R; Pauletta, G; Penzo, A; Salvato, G; Schiavon, P; Villari, A [INFN, Messina (Italy) INFN, Trieste (Italy) INFN, Udine (Italy); Gorin, A M; Meschanin, A P; Nurushev, S B; Rakhmatov, V E; Rykalin, V L; Solovyanov, V L; Vasiliev, A N; Vasil' chencko, V G [Institute for High Energy Physics, Serpukhov (USSR); Oshima, N; Yamada, R [Fermi National Accelerator Lab., Batavia, IL (USA); Takeutchi, F [Kyoto-Sanyo Univ., Kyoto (Japan); Yoshida, T [Osaka City Univ. (Japan); Akchurin, N; Onel, Y; Newsom, C

1991-07-01

An approach to a high quality of the Level-1 Trigger is investigated on the basis of a topological trigger device. It will be realized by using scintillating fibers and position-sensitive photomultipliers, both considered as potential candidates of new detector-components thanks to their excellent time characteristics and high radiation resistances. The device is characterized in particular by its simple concept and reliable operation supported by the mature technologies emploied. The major interests of such a scheme under LHC environments reside in its capability of selcting high pperpendicular to tracks in real time, its optional immunity against low pperpendicular to tracks and loopers, as well as its effective links to other associated devices in the complex of a vertex detector. (orig.).

Topological trigger device using scintillating fibres and position-sensitive photomultipliers

CERN Document Server

Agoritsas, V; Dufournaud, J; Giacomich, R; Gorin, A M; Kuroda, K; Meshchanin, A P; Newsom, C R; Nurushev, S B; Önel, Y M; Oshima, N; Pauletta, G; Penzo, Aldo L; Rakhmatov, V E; Rykalin, V I; Salvato, G; Schiavon, R P; Sillou, D; Solovyanov, V L; Takeutchi, F; Vasilev, V; Vasilchenko, V G; Villari, A C C; Yamada, R; Toshida, T; CERN. Geneva. Detector Research and Development Committee

1990-01-01

An approach to a high-quality level-1 trigger is proposed on the basis of a topological device that will be realized by using scintillating fibres and position-sensitive photomultipliers, both of which are considered as potential candidates for new detector components, thanks to their excellent time characteristics and high radiation resistance. The device is characterized, in particular, by its simple concept and reliable functioning, which are a result of the mature technologies employed. In the LHC environment, the major interests of such a scheme reside in its capability to select high ptransv. tracks in real time, in its optional immunity against low ptransv. tracks and loopers, as well as in its effective links to other associated devices within the complex of a vertex detector.

Adaptive Liquid Crystal Windows

Energy Technology Data Exchange (ETDEWEB)

Taheri, Bahman; Bodnar, Volodymyr

2011-12-31

Energy consumption by private and commercial sectors in the U.S. has steadily grown over the last decade. The uncertainty in future availability of imported oil, on which the energy consumption relies strongly, resulted in a dramatic increase in the cost of energy. About 20% of this consumption are used to heat and cool houses and commercial buildings. To reduce dependence on the foreign oil and cut down emission of greenhouse gases, it is necessary to eliminate losses and reduce total energy consumption by buildings. To achieve this goal it is necessary to redefine the role of the conventional windows. At a minimum, windows should stop being a source for energy loss. Ideally, windows should become a source of energy, providing net gain to reduce energy used to heat and cool homes. It is possible to have a net energy gain from a window if its light transmission can be dynamically altered, ideally electronically without the need of operator assistance, providing optimal control of the solar gain that varies with season and climate in the U.S. In addition, the window must not require power from the building for operation. Resolution of this problem is a societal challenge and of national interest and will have a broad global impact. For this purpose, the year-round, allclimate window solution to provide an electronically variable solar heat gain coefficient (SHGC) with a wide dynamic range is needed. AlphaMicron, Inc. (AMI) developed and manufactured 1ft × 1ft prototype panels for the world’s first auto-adjusting Adaptive Liquid Crystal Windows (ALCWs) that can operate from sunlight without the need for external power source and demonstrate an electronically adjustable SHGC. This novel windows are based on AlphaMicron’s patented e-Tint® technology, a guesthost liquid crystal system implemented on flexible, optically clear plastic films. This technology is suitable both for OEM and aftermarket (retro-fitting) lamination to new and existing windows. Low level of

National Fenestration Rating Council (NFRC) | Efficient Windows

Science.gov (United States)

Collaborative Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring

U-Factor (U-value) | Efficient Windows Collaborative

Science.gov (United States)

Foundry Foundry New Construction Windows Window Selection Tool Selection Process Design Guidance Installation Replacement Windows Window Selection Tool Assessing Options Selection Process Design Guidance Installation Understanding Windows Benefits Design Considerations Measuring Performance Performance Standards

Morin impedes Yap nuclear translocation and fosters apoptosis through suppression of Wnt/β-catenin and NF-κB signaling in Mst1 overexpressed HepG2 cells

Energy Technology Data Exchange (ETDEWEB)

Perumal, NaveenKumar [Department of Biochemistry, University of Madras, Guindy Campus, Chennai 600025, Tamil Nadu (India); Perumal, MadanKumar [Department of Biochemistry, University of Madras, Guindy Campus, Chennai 600025, Tamil Nadu (India); Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 (United States); Kannan, Anbarasu [Department of Cellular and Molecular Biology, The University of Texas Health Science Center, Tyler, Texas (United States); Subramani, Kumar [Centre for Biotechnology, Anna University, Chennai 600025, Tamil Nadu (India); Halagowder, Devaraj [Department of Zoology, University of Madras, Guindy Campus, Chennai 600025, Tamil Nadu (India); Sivasithamparam, NiranjaliDevaraj, E-mail: profniranjali@gmail.com [Department of Biochemistry, University of Madras, Guindy Campus, Chennai 600025, Tamil Nadu (India)

2017-06-15

Recent clinical and experimental evidences strongly acclaim Yes-associated protein (Yap), a key oncogenic driver in liver carcinogenesis, as a therapeutic target. Of the known multiple schemes to inhibit Yap activity, activation of Mammalian Sterile 20-like Kinase 1 (Mst1), an upstream regulator of Yap, appears to be a promising one. In this study, we hypothesize that morin, a bioflavonoid, mediates its anti-cancer effect through the activation of Mst1/hippo signaling in liver cancer cells. To test this hypothesis, both full length Mst1 (F-Mst1) and kinase active N-terminal Mst1 (N-Mst1)-overexpressed HepG2 cells were used. Exposure of F-Mst1 overexpressed HepG2 cells to morin activated Mst1 by caspase-3 cleavage and thereby inhibited Yap nuclear translocation and fostered apoptosis. Morin suppressed NF-κB p65 and Wnt/β-catenin signaling through Mst1 activation via cleavage and phosphorylation, leading to cell death. Annexin-V/PI staining further confirmed the induction of apoptosis in morin treated F-Mst1 overexpressed cells. The present study shows that morin targets cell survival molecules such as NF-κB p65 and β-catenin through activation of hippo signaling. Therefore, morin could be considered as a potential anti-cancer agent against liver cancer. - Highlights: • Morin induced cytotoxicity in cultured HepG2 cells. • Morin activated hippo pathway via Mst1 activation in transfected HepG2 cells. • Morin suppressed Wnt/β-catenin signaling and induced G0/G1 cell cycle arrest. • Morin inhibited NF-κB signaling through Mst1 activation in transfected HepG2 cells. • Morin potentiates apoptosis through Mst1-JNK-caspase mediated mechanism in HepG2 cells.

Morin impedes Yap nuclear translocation and fosters apoptosis through suppression of Wnt/β-catenin and NF-κB signaling in Mst1 overexpressed HepG2 cells

International Nuclear Information System (INIS)

Perumal, NaveenKumar; Perumal, MadanKumar; Kannan, Anbarasu; Subramani, Kumar; Halagowder, Devaraj; Sivasithamparam, NiranjaliDevaraj

2017-01-01

Recent clinical and experimental evidences strongly acclaim Yes-associated protein (Yap), a key oncogenic driver in liver carcinogenesis, as a therapeutic target. Of the known multiple schemes to inhibit Yap activity, activation of Mammalian Sterile 20-like Kinase 1 (Mst1), an upstream regulator of Yap, appears to be a promising one. In this study, we hypothesize that morin, a bioflavonoid, mediates its anti-cancer effect through the activation of Mst1/hippo signaling in liver cancer cells. To test this hypothesis, both full length Mst1 (F-Mst1) and kinase active N-terminal Mst1 (N-Mst1)-overexpressed HepG2 cells were used. Exposure of F-Mst1 overexpressed HepG2 cells to morin activated Mst1 by caspase-3 cleavage and thereby inhibited Yap nuclear translocation and fostered apoptosis. Morin suppressed NF-κB p65 and Wnt/β-catenin signaling through Mst1 activation via cleavage and phosphorylation, leading to cell death. Annexin-V/PI staining further confirmed the induction of apoptosis in morin treated F-Mst1 overexpressed cells. The present study shows that morin targets cell survival molecules such as NF-κB p65 and β-catenin through activation of hippo signaling. Therefore, morin could be considered as a potential anti-cancer agent against liver cancer. - Highlights: • Morin induced cytotoxicity in cultured HepG2 cells. • Morin activated hippo pathway via Mst1 activation in transfected HepG2 cells. • Morin suppressed Wnt/β-catenin signaling and induced G0/G1 cell cycle arrest. • Morin inhibited NF-κB signaling through Mst1 activation in transfected HepG2 cells. • Morin potentiates apoptosis through Mst1-JNK-caspase mediated mechanism in HepG2 cells.

Hybrid MnO2/carbon nanotube-VN/carbon nanotube supercapacitors

Science.gov (United States)

Su, Y.; Zhitomirsky, I.

2014-12-01

Composite materials, containing fibrous VN nanoparticles and multiwalled carbon nanotubes (MWCNT) are prepared by a chemical method for application in electrochemical supercapacitors. We demonstrate for the first time that VN-MWCNT electrodes exhibit good capacitive behavior in 0.5 M Na2SO4 electrolyte in a negative voltage window of 0.9 V. Quartz crystal microbalance studies provide an insight into the mechanism of charge storage. Composite VN-MWCNT materials show significant improvement in capacitance, compared to individual VN and MWCNT materials. Testing results indicate that VN-MWCNT electrodes exhibit high specific capacitance at high mass loadings in the range of 10-30 mg cm-2, good capacitance retention at scan rates in the range of 2-200 mV s-1 and good cycling stability. The highest specific capacitance of 160 F g-1 is achieved at a scan rate of 2 mV s-1. The new findings open a new and promising strategy in the fabrication of hybrid devices based on VN. The proof-of-principle is demonstrated by the fabrication of hybrid supercapacitor devices based on VN-MWCNT negative electrodes and MnO2 -MWCNT positive electrodes with voltage window of 1.8 V in aqueous 0.5 M Na2SO4 electrolyte. The hybrid VN-MWCNT/MnO2-MWCNT supercapacitor cells show promising capacitive and power-energy characteristics.

Role of YAP/TAZ in cell-matrix adhesion-mediated signalling and mechanotransduction

International Nuclear Information System (INIS)

Dupont, Sirio

2016-01-01

Signalling from the extracellular matrix (ECM) is a fundamental cellular input that sustains proliferation, opposes cell death and regulates differentiation. Through integrins, cells perceive both the chemical composition and physical properties of the ECM. In particular, cell behaviour is profoundly influenced by the mechanical elasticity or stiffness of the ECM, which regulates the ability of cells to develop forces through their contractile actomyosin cytoskeleton and to mature focal adhesions. This mechanosensing ability affects fundamental cellular functions, such that alterations of ECM stiffness is nowadays considered not a simple consequence of pathology, but a causative input driving aberrant cell behaviours. We here discuss recent advances on how mechanical signals intersect nuclear transcription and in particular the activity of YAP/TAZ transcriptional coactivators, known downstream transducers of the Hippo pathway and important effectors of ECM mechanical cues.

Role of YAP/TAZ in cell-matrix adhesion-mediated signalling and mechanotransduction

Energy Technology Data Exchange (ETDEWEB)

Dupont, Sirio, E-mail: sirio.dupont@unipd.it

2016-04-10

Signalling from the extracellular matrix (ECM) is a fundamental cellular input that sustains proliferation, opposes cell death and regulates differentiation. Through integrins, cells perceive both the chemical composition and physical properties of the ECM. In particular, cell behaviour is profoundly influenced by the mechanical elasticity or stiffness of the ECM, which regulates the ability of cells to develop forces through their contractile actomyosin cytoskeleton and to mature focal adhesions. This mechanosensing ability affects fundamental cellular functions, such that alterations of ECM stiffness is nowadays considered not a simple consequence of pathology, but a causative input driving aberrant cell behaviours. We here discuss recent advances on how mechanical signals intersect nuclear transcription and in particular the activity of YAP/TAZ transcriptional coactivators, known downstream transducers of the Hippo pathway and important effectors of ECM mechanical cues.

Right-to-left-shunt detected by c-TCD using the orbital window in comparison with temporal bone windows.

Science.gov (United States)

Kobayashi, Kazuto; Kimura, Kazumi; Iguchi, Yasuyuki; Sakai, Kenichirou; Aoki, Junya; Iwanaga, Takeshi; Shibazaki, Kensaku

2012-01-01

There have been some reports on right-to-left shunt as a cause of cryptogenic stroke. Although contrast transcranial Doppler (c-TCD) can detect RLS, an insufficient temporal window has occasionally restricted its applicability. Thus, we compared the rates of detecting RLS among temporal windows for the middle cerebral arteries (MCAs) and the orbital window for the internal carotid artery (ICA) on c-TCD. We used c-TCD to detect RLS in patients with suspected ischemic stroke. We enrolled patients who had both sufficient bilateral temporal windows for MCAs and a right orbital window for ICA and performed c-TCD using all three windows simultaneously. We enrolled 106 consecutive patients and identified microembolic signals (MES) in 30 (28%) of them. Among these 30 patients, 15 had MES from all 3 windows. When these 30 patients were defined as being positive for RLS, the rates of detection were 67%, 73%, and 80% from the right temporal, left temporal, and right orbital windows, respectively (P= .795). The right orbital window as well as the temporal window for c-TCD could detect RLS. Insonation from the orbital window should be useful for patients who lack temporal windows. Copyright © 2010 by the American Society of Neuroimaging.

Functional study of the Hap4-like genes suggests that the key regulators of carbon metabolism HAP4 and oxidative stress response YAP1 in yeast diverged from a common ancestor.

Directory of Open Access Journals (Sweden)

Nataliya Petryk

Full Text Available The transcriptional regulator HAP4, induced by respiratory substrates, is involved in the balance between fermentation and respiration in S. cerevisiae. We identified putative orthologues of the Hap4 protein in all ascomycetes, based only on a conserved sixteen amino acid-long motif. In addition to this motif, some of these proteins contain a DNA-binding motif of the bZIP type, while being nonetheless globally highly divergent. The genome of the yeast Hansenula polymorpha contains two HAP4-like genes encoding the protein HpHap4-A which, like ScHap4, is devoid of a bZIP motif, and HpHap4-B which contains it. This species has been chosen for a detailed examination of their respective properties. Based mostly on global gene expression studies performed in the S. cerevisiae HAP4 disruption mutant (ScΔhap4, we show here that HpHap4-A is functionally equivalent to ScHap4, whereas HpHap4-B is not. Moreover HpHAP4-B is able to complement the H2O2 hypersensitivity of the ScYap1 deletant, YAP1 being, in S. cerevisiae, the main regulator of oxidative stress. Finally, a transcriptomic analysis performed in the ScΔyap1 strain overexpressing HpHAP4-B shows that HpHap4-B acts both on oxidative stress response and carbohydrate metabolism in a manner different from both ScYap1 and ScHap4. Deletion of these two genes in their natural host, H. polymorpha, confirms that HpHAP4-A participates in the control of the fermentation/respiration balance, while HpHAP4-B is involved in oxidative stress since its deletion leads to hypersensitivity to H2O2. These data, placed in an evolutionary context, raise new questions concerning the evolution of the HAP4 transcriptional regulation function and suggest that Yap1 and Hap4 have diverged from a unique regulatory protein in the fungal ancestor.

Windows PowerShell 20 Bible

CERN Document Server

Lee, Thomas; Schill, Mark E; Tanasovski, Tome

2011-01-01

Here's the complete guide to Windows PowerShell 2.0 for administrators and developers Windows PowerShell is Microsoft's next-generation scripting and automation language. This comprehensive volume provides the background that IT administrators and developers need in order to start using PowerShell automation in exciting new ways. It explains what PowerShell is, how to use the language, and specific ways to apply PowerShell in various technologies. Windows PowerShell is Microsoft's standard automation tool and something that every Windows administrator will eventually have to understand; this b

Mastering Microsoft Windows Server 2008 R2

CERN Document Server

Minasi, Mark; Finn, Aidan

2010-01-01

The one book you absolutely need to get up and running with Windows Server 2008 R2. One of the world's leading Windows authorities and top-selling author Mark Minasi explores every nook and cranny of the latest version of Microsoft's flagship network operating system, Windows Server 2008 R2, giving you the most in-depth coverage in any book on the market.: Focuses on Windows Windows Server 2008 R2, the newest version of Microsoft's Windows' server line of operating system, and the ideal server for new Windows 7 clients; Author Mark Minasi is one of the world's leading Windows authorities and h

Schematic Window Methodology Project

Data.gov (United States)

National Aeronautics and Space Administration — The aim of this IRAD is to produce a generic launch window analyzer (SWM) that allows for large-scale rapid analysis of a launch window and orbit design trade space....

Windows 7 resource kit

CERN Document Server

Northrup, Tony; Honeycutt, Jerry; Wilson, Ed

2009-01-01

In-depth and comprehensive, this RESOURCE KIT delivers the information you need to administer your Windows 7 system. You get authoritative technical guidance from those who know the technology best-Microsoft Most Valuable Professionals (MVPs) and the Windows 7 product team-along with essential scripts and resources. In addition, "Direct from the Source" sidebars offer deep insights and troubleshooting tips from the Windows 7 team. Get expert guidance on how to: Use Microsoft Deployment Toolkit best practices and tools. Plan user-state migration and test application compatibility.

The Efficient Windows Collaborative

Energy Technology Data Exchange (ETDEWEB)

Petermann, Nils

2006-03-31

The Efficient Windows Collaborative (EWC) is a coalition of manufacturers, component suppliers, government agencies, research institutions, and others who partner to expand the market for energy efficient window products. Funded through a cooperative agreement with the U.S. Department of Energy, the EWC provides education, communication and outreach in order to transform the residential window market to 70% energy efficient products by 2005. Implementation of the EWC is managed by the Alliance to Save Energy, with support from the University of Minnesota and Lawrence Berkeley National Laboratory.

Charge reconstruction in large-area photomultipliers

Science.gov (United States)

Grassi, M.; Montuschi, M.; Baldoncini, M.; Mantovani, F.; Ricci, B.; Andronico, G.; Antonelli, V.; Bellato, M.; Bernieri, E.; Brigatti, A.; Brugnera, R.; Budano, A.; Buscemi, M.; Bussino, S.; Caruso, R.; Chiesa, D.; Corti, D.; Dal Corso, F.; Ding, X. F.; Dusini, S.; Fabbri, A.; Fiorentini, G.; Ford, R.; Formozov, A.; Galet, G.; Garfagnini, A.; Giammarchi, M.; Giaz, A.; Insolia, A.; Isocrate, R.; Lippi, I.; Longhitano, F.; Lo Presti, D.; Lombardi, P.; Marini, F.; Mari, S. M.; Martellini, C.; Meroni, E.; Mezzetto, M.; Miramonti, L.; Monforte, S.; Nastasi, M.; Ortica, F.; Paoloni, A.; Parmeggiano, S.; Pedretti, D.; Pelliccia, N.; Pompilio, R.; Previtali, E.; Ranucci, G.; Re, A. C.; Romani, A.; Saggese, P.; Salamanna, G.; Sawy, F. H.; Settanta, G.; Sisti, M.; Sirignano, C.; Spinetti, M.; Stanco, L.; Strati, V.; Verde, G.; Votano, L.

2018-02-01

Large-area PhotoMultiplier Tubes (PMT) allow to efficiently instrument Liquid Scintillator (LS) neutrino detectors, where large target masses are pivotal to compensate for neutrinos' extremely elusive nature. Depending on the detector light yield, several scintillation photons stemming from the same neutrino interaction are likely to hit a single PMT in a few tens/hundreds of nanoseconds, resulting in several photoelectrons (PEs) to pile-up at the PMT anode. In such scenario, the signal generated by each PE is entangled to the others, and an accurate PMT charge reconstruction becomes challenging. This manuscript describes an experimental method able to address the PMT charge reconstruction in the case of large PE pile-up, providing an unbiased charge estimator at the permille level up to 15 detected PEs. The method is based on a signal filtering technique (Wiener filter) which suppresses the noise due to both PMT and readout electronics, and on a Fourier-based deconvolution able to minimize the influence of signal distortions—such as an overshoot. The analysis of simulated PMT waveforms shows that the slope of a linear regression modeling the relation between reconstructed and true charge values improves from 0.769 ± 0.001 (without deconvolution) to 0.989 ± 0.001 (with deconvolution), where unitary slope implies perfect reconstruction. A C++ implementation of the charge reconstruction algorithm is available online at [1].

Composition of 12-18th century window glass in Belgium: Non-figurative windows in secular buildings and stained-glass windows in religious buildings

International Nuclear Information System (INIS)

Schalm, Olivier; Janssens, Koen; Wouters, Hilde; Caluwe, Danielle

2007-01-01

A set of ca. 500 window glass fragments originating from different historical sites in Belgium and covering the period 12 th -18 th century was analyzed by means of electron probe microanalysis. Most samples are archaeological finds deriving from non-figurative windows in secular buildings. However, the analyzed set also contains glass sampled from still existing non-figurative windows in secular buildings and stained-glass windows in religious buildings. A sudden compositional change at the end of the 14 th century can be noticed among the series of glass compositions that were obtained. These changes could be related to the use of different glassmaker recipes and to the introduction of new raw materials for glass making

Composition of 12-18 th century window glass in Belgium: Non-figurative windows in secular buildings and stained-glass windows in religious buildings

Science.gov (United States)

Schalm, Olivier; Janssens, Koen; Wouters, Hilde; Caluwé, Danielle

2007-07-01

A set of ca. 500 window glass fragments originating from different historical sites in Belgium and covering the period 12 th-18 th century was analyzed by means of electron probe microanalysis. Most samples are archaeological finds deriving from non-figurative windows in secular buildings. However, the analyzed set also contains glass sampled from still existing non-figurative windows in secular buildings and stained-glass windows in religious buildings. A sudden compositional change at the end of the 14 th century can be noticed among the series of glass compositions that were obtained. These changes could be related to the use of different glassmaker recipes and to the introduction of new raw materials for glass making.

In-depth study of single photon time resolution for the Philips digital silicon photomultiplier

International Nuclear Information System (INIS)

Liu, Z.; Pizzichemi, M.; Ghezzi, A.; Paganoni, M.; Gundacker, S.; Auffray, E.; Lecoq, P.

2016-01-01

The digital silicon photomultiplier (SiPM) has been commercialised by Philips as an innovative technology compared to analog silicon photomultiplier devices. The Philips digital SiPM, has a pair of time to digital converters (TDCs) connected to 12800 single photon avalanche diodes (SPADs). Detailed measurements were performed to understand the low photon time response of the Philips digital SiPM. The single photon time resolution (SPTR) of every single SPAD in a pixel consisting of 3200 SPADs was measured and an average value of 85 ps full width at half maximum (FWHM) was observed. Each SPAD sends the signal to the TDC with different signal propagation time, resulting in a so called trigger network skew. This distribution of the trigger network skew for a pixel (3200 SPADs) has been measured and a variation of 50 ps FWHM was extracted. The SPTR of the whole pixel is the combination of SPAD jitter, trigger network skew, and the SPAD non-uniformity. The SPTR of a complete pixel was 103 ps FWHM at 3.3 V above breakdown voltage. Further, the effect of the crosstalk at a low photon level has been studied, with the two photon time resolution degrading if the events are a combination of detected (true) photons and crosstalk events. Finally, the time response to multiple photons was investigated.

Analysis of transit time spread on FBK silicon photomultipliers

International Nuclear Information System (INIS)

Acerbi, F.; Gola, A.; Ferri, A.; Zorzi, N.; Paternoster, G.; Piemonte, C.

2015-01-01

In this paper we studied one of the aspects potentially limiting the single-photon time-resolution (SPTR) of the silicon photomultiplier (SiPM): the transit time spread (TTS). We illuminated the SiPM in different positions with a fast-pulsed laser collimated to a circular spot of 0.2 mm-diameter and acquired bi-dimensional maps of the avalanche-signal arrival time of RGB and RGB-HD SiPMs, produced at FBK. We studied the effect of both the number of bonding wires connecting the device to the package and the layout of the top-metal connection (on the device). We found that the TTS does not simply depend on the trace length between the cell and the bonding pad and it could vary in the range between tens of picoseconds (with 3 bonding connections) to more than one hundred of picoseconds (with one connection)

The performance of silicon photomultipliers in Cherenkov TOF PET

International Nuclear Information System (INIS)

Dolenec, Rok; Korpar, Samo; Krizan, Peter; Pestotink, Rok

2015-01-01

In time-of-flight positron emission tomography (TOF PET) one of the main factors limiting the time resolution is the time evolution of the scintillation process. This can be avoided by using exclusively the Cherenkov light produced in a suitable material. Sub 100 ps FWHM timing has already been experimentally demonstrated but with a drawback of relatively low detection efficiency due to the photodetectors used. In this work silicon photomultipliers (SiPMs) are considered as a photodetector in Cherenkov TOF PET. The detection efficiency can be significantly improved by using SiPMs, however, at room temperature the SiPM dark counts introduce a significant source of fake coincidences. SiPM samples from different producers were tested in a simple back-to-back setup in combination with lead fluoride Cherenkov radiators. Results for coincidence timing, detection efficiency and effects of dark counts at different temperatures and SiPM overvoltages are presented.

Measurement of amplitude fluctuations in a rapid response photomultiplier

International Nuclear Information System (INIS)

Raimbault, P.

1961-01-01

In order to measure amplitude fluctuations in a rapid response photomultiplier, two independent random variables are introduced which determine the shape of the anode pulse. The energy of each pulse, which depends directly on the gain and the variance, is the first variable; amplitude fluctuations, functions of the first variable, depend as well on the pulse width which in turn constitutes the second variable. The results obtained on the variations of the maximum impulse, using a steep-edged pulse broadening circuit, and those obtained on the statistical variations of the gain, are compared to show that the variance relative to the maximum amplitude of the signal is greater than that of the gain. Within the limits of these fluctuations are shown the contribution of the secondary emission coefficient of the first dynode, and that of the mean secondary emission coefficient of the multiplier. (author) [fr

The electrical and thermal transport properties of hybrid zigzag graphene-BN nanoribbons

Science.gov (United States)

Gao, Song; Lu, Wei; Zheng, Guo-Hui; Jia, Yalei; Ke, San-Huang

2017-06-01

The electron and phonon transport in hybrid graphene-BN zigzag nanoribbons are investigated by the nonequilibrium Green’s function method combined with density functional theory calculations. A 100% spin-polarized electron transport in a large energy window around the Fermi level is found and this behavior is independent of the ribbon width as long as there contain 3 zigzag carbon chains. The phonon transport calculations show that the ratio of C-chain number to BN-chain number will modify the thermal conductance of the hybrid nanoribbon in a complicated manner.

The electrical and thermal transport properties of hybrid zigzag graphene-BN nanoribbons

International Nuclear Information System (INIS)

Gao, Song; Lu, Wei; Zheng, Guo-Hui; Jia, Yalei; Ke, San-Huang

2017-01-01

The electron and phonon transport in hybrid graphene-BN zigzag nanoribbons are investigated by the nonequilibrium Green’s function method combined with density functional theory calculations. A 100% spin-polarized electron transport in a large energy window around the Fermi level is found and this behavior is independent of the ribbon width as long as there contain 3 zigzag carbon chains. The phonon transport calculations show that the ratio of C-chain number to BN-chain number will modify the thermal conductance of the hybrid nanoribbon in a complicated manner. (paper)

High performance sapphire windows

Science.gov (United States)

Bates, Stephen C.; Liou, Larry

1993-02-01

High-quality, wide-aperture optical access is usually required for the advanced laser diagnostics that can now make a wide variety of non-intrusive measurements of combustion processes. Specially processed and mounted sapphire windows are proposed to provide this optical access to extreme environment. Through surface treatments and proper thermal stress design, single crystal sapphire can be a mechanically equivalent replacement for high strength steel. A prototype sapphire window and mounting system have been developed in a successful NASA SBIR Phase 1 project. A large and reliable increase in sapphire design strength (as much as 10x) has been achieved, and the initial specifications necessary for these gains have been defined. Failure testing of small windows has conclusively demonstrated the increased sapphire strength, indicating that a nearly flawless surface polish is the primary cause of strengthening, while an unusual mounting arrangement also significantly contributes to a larger effective strength. Phase 2 work will complete specification and demonstration of these windows, and will fabricate a set for use at NASA. The enhanced capabilities of these high performance sapphire windows will lead to many diagnostic capabilities not previously possible, as well as new applications for sapphire.

Front-end circuit for position sensitive silicon and vacuum tube photomultipliers with gain control and depth of interaction measurement

International Nuclear Information System (INIS)

Herrero, Vicente; Colom, Ricardo; Gadea, Rafael; Lerche, Christoph W.; Cerda, Joaquin; Sebastia, Angel; Benlloch, Jose M.

2007-01-01

Silicon Photomultipliers, though still under development for mass production, may be an alternative to traditional Vacuum Photomultipliers Tubes (VPMT). As a consequence, electronic front-ends initially designed for VPMT will need to be modified. In this simulation, an improved architecture is presented which is able to obtain impact position and depth of interaction of a gamma ray within a continuous scintillation crystal, using either kind of PM. A current sensitive preamplifier stage with individual gain adjustment interfaces the multi-anode PM outputs with a current division resistor network. The preamplifier stage allows to improve front-end processing delay and temporal resolution behavior as well as to increase impact position calculation resolution. Depth of interaction (DOI) is calculated from the width of the scintillation light distribution, which is related to the sum of voltages in resistor network input nodes. This operation is done by means of a high-speed current mode scheme

A digital silicon photomultiplier with multiple time-to-digital converters

Energy Technology Data Exchange (ETDEWEB)

Garutti, Erika [University Hamburg (Germany); Silenzi, Alessandro [DESY, Hamburg (Germany); Xu, Chen [DESY, Hamburg (Germany); University Hamburg (Germany)

2013-07-01

A silicon photomultiplier (SiPM) with pixel level signal digitization and column-wise connected time-to-digital converters (TDCs) has been developed for an endoscopic Positron Emission Tomography (PET) detector. A digital SiPM has pixels consist of a single photon avalanche diode (SPAD) and circuit elements to optimize overall dark counts and temporal response. Compared with conventional analog SiPM, digital SiPM's direct signal route from SPAD to TDC improves single photon time resolution. In addition, using multiple TDCs can perform the statistical estimation of the time-of-arrival in multiple photon detection case such as readout of scintillation crystals. Characterization measurements of the prototype digital SiPM and a Monte-Carlo simulation to predict the timing performance of the PET detector are shown.

Web-based hybrid mobile apps: state of the practice and research opportunities

NARCIS (Netherlands)

Malavolta, Ivano

2016-01-01

This paper describes the contents of a tutorial on web-based hybrid mobile apps. Nowadays millions of mobile apps are downloaded and used all over the world. Mobile apps are distributed via different app stores like Google Play Store, the Apple App Store, the Windows Phone Store. One of the most

Analytical models of probability distribution and excess noise factor of solid state photomultiplier signals with crosstalk

International Nuclear Information System (INIS)

Vinogradov, S.

2012-01-01

Silicon Photomultipliers (SiPM), also called Solid State Photomultipliers (SSPM), are based on Geiger mode avalanche breakdown that is limited by a strong negative feedback. An SSPM can detect and resolve single photons due to the high gain and ultra-low excess noise of avalanche multiplication in this mode. Crosstalk and afterpulsing processes associated with the high gain introduce specific excess noise and deteriorate the photon number resolution of the SSPM. The probabilistic features of these processes are widely studied because of its significance for the SSPM design, characterization, optimization and application, but the process modeling is mostly based on Monte Carlo simulations and numerical methods. In this study, crosstalk is considered to be a branching Poisson process, and analytical models of probability distribution and excess noise factor (ENF) of SSPM signals based on the Borel distribution as an advance on the geometric distribution models are presented and discussed. The models are found to be in a good agreement with the experimental probability distributions for dark counts and a few photon spectrums in a wide range of fired pixels number as well as with observed super-linear behavior of crosstalk ENF.

Time resolution of Burle 85001 micro-channel plate photo-multipliers in comparison with Hamamatsu R2083

Energy Technology Data Exchange (ETDEWEB)

V. Baturin; V. Burkert; W. Kim; S. Majewsky; D. Nekrasov; K. Park; V. Popov; E. S. Smith; D. Son; S. S. Stepanyan; C. Zorn

2005-06-01

The CLAS detector will require improvements in its particle identification system to take advantage of the higher energies provided by the Jefferson Laboratory accelerator upgrade to 12 GeV. To this end, we have studied the timing characteristics of the micro-channel plate photo-multiplier 85001 from Burle, which can be operated in a high magnetic field environment. For reference and comparison, measurements were also made using the standard PMT R2083 from Hamamatsu using two timing methods. The cosmic ray method, which utilizes three identical scintillating counters 2cm x 3cm x 50cm with PMs at the ends, yields 59.1(0.7)ps. The location method of particles from radiative source with known coordinates has been used to compare timing resolutions of R2083 and Burle-85001. This ''coordinate method'' requires only one counter instrumented with two PMs and it yields 59.5(0.7)ps. For the micro-channel plate photomultiplier from Burle with an external amplification of 10 to the signals, the co ordinate method yields 130(4)ps. This method also makes it possible to estimate the number of primary photo-electrons.

Windows 7 The Missing Manual

CERN Document Server

Pogue, David

2010-01-01

In early reviews, geeks raved about Windows 7. But if you're an ordinary mortal, learning what this new system is all about will be challenging. Fear not: David Pogue's Windows 7: The Missing Manual comes to the rescue. Like its predecessors, this book illuminates its subject with reader-friendly insight, plenty of wit, and hardnosed objectivity for beginners as well as veteran PC users. Windows 7 fixes many of Vista's most painful shortcomings. It's speedier, has fewer intrusive and nagging screens, and is more compatible with peripherals. Plus, Windows 7 introduces a slew of new features,

Microsoft Windows Operating System Essentials

CERN Document Server

Carpenter, Tom

2012-01-01

A full-color guide to key Windows 7 administration concepts and topics Windows 7 is the leading desktop software, yet it can be a difficult concept to grasp, especially for those new to the field of IT. Microsoft Windows Operating System Essentials is an ideal resource for anyone new to computer administration and looking for a career in computers. Delving into areas such as fundamental Windows 7 administration concepts and various desktop OS topics, this full-color book addresses the skills necessary for individuals looking to break into a career in IT. Each chapter begins with a list of topi

Improved Windows for Cold Climates

DEFF Research Database (Denmark)

Laustsen, Jacob Birck; Svendsen, Svend

2005-01-01

considerably by reducing the frame width, which results in a larger transparent area causing a larger solar gain but still main-taining a low thermal transmittance. Using three layers of glass with large gaps, using very slim frame profiles, and omitting the edge constructions that normally causes thermal...... windows with improved energy performance. Traditionally evaluation of the energy performance of windows has focused on the thermal transmittance, but as windows differ from the rest of the building envelope by allowing solar energy to enter the building, the total solar energy transmittance is equally...... important. In the heating season in cold climates the solar gain through windows can be utilized for space heating which results in a corresponding reduction in the energy production that is often based on fossil fuels. A suitable quantity for evaluating the energy performance of windows in a simple...

Nanoporous hybrid electrolytes

KAUST Repository

Schaefer, Jennifer L.

2011-01-01

Oligomer-suspended SiO2-polyethylene glycol nanoparticles are studied as porous media electrolytes. At SiO2 volume fractions, , bracketing a critical value y ≈ 0.29, the suspensions jam and their mechanical modulus increase by more than seven orders. For >y, the mean pore diameter is close to the anion size, yet the ionic conductivity remains surprisingly high and can be understood, at all , using a simple effective medium model proposed by Maxwell. SiO 2-polyethylene glycol hybrid electrolytes are also reported to manifest attractive electrochemical stability windows (0.3-6.3 V) and to reach a steady-state interfacial impedance when in contact with metallic lithium. © 2010 The Royal Society of Chemistry.

Dark noise rates in irradiated silicon photomultiplier arrays

Energy Technology Data Exchange (ETDEWEB)

Bachmann, Sebastian; Comerma, Albert; Gerick, David; Han, Xiaoxue; Hansmann-Menzemer, Stephanie; Kecke, Matthieu; Leverington, Blake; Mazorra de Cos, Jose; Mitzel, Dominik; Neuner, Max; Uwer, Ulrich [Physikalisches Institut, Universitaet Heidelberg (Germany); Collaboration: LHCb-Collaboration

2016-07-01

The planned downstream tracking system - the Scintillating Fibre Tracker - for the LHCb upgrade uses silicon photomultiplier (SiPM) arrays of 128 channels to read out mats made of 250 μm diameter scintillating fibres. In the LHCb environment the neutron flux degrades the silicon detectors to the edge of an acceptable performance in terms of DCR. Studies have shown that the dark count rate (DCR) of the SiPMs increases linearly with the neutron flux. Towards the end of the designed lifetime of the experiment the DCR per SiPM channel operated at T = -40 C is expected to reach a few MHz after partial annealing. To reduce the impact of the DCR - while at the same time provide efficient hit reconstruction - a clustering algorithm is developed to separate signal from noise. A brief introduction into the custom designed read-out ASIC and the cluster algorithm are presented along with the studies of the dark count cluster rate dependency on the neutron flux, the DCR per channel and the effects of the applied signal thresholds for the clustering algorithm.

Solid-State Photomultiplier with Integrated Front End Electronics

Science.gov (United States)

Christian, James; Stapels, Christopher; Johnson, Erik; Mukhopadhyay, Sharmistha; Jie Chen, Xiao; Miskimen, Rory

2009-10-01

The instrumentation cost of physics experiments has been reduced per channel, by the use of solid-state detectors, but these cost-effective techniques have not been translated to scintillation-based detectors. When considering photodetectors, the cost per channel is determined by the use of high-voltage, analog-to-digital converters, BNC cables, and any other ancillary devices. The overhead associated with device operation limits the number of channels for the detector system, while potentially limiting the scope of physics that can be explored. The PRIMEX experiment at JLab, which is being designed to measure the radiative widths of the η and η' pseudo-scalar mesons for a more comprehensive understanding of QCD at low energies, is an example where CMOS solid-state photomultipliers (SSPMs) can be implemented. The ubiquitous nature of CMOS allows for on-chip signal processing to provide front-end electronics within the detector package. We present the results of the device development for the PRIMEX calorimeter, discussing the characteristics of SSPMs, the potential cost savings, and experimental results of on-chip signal processing.

Characterization of Silicon Photomultiplier Detectors using Cosmic Radiation

Science.gov (United States)

Zavala, Favian; Castro, Juan; Niduaza, Rexavalmar; Wedel, Zachary; Fan, Sewan; Ritt, Stefan; Fatuzzo, Laura

2014-03-01

The silicon photomultiplier light detector has gained a lot of attention lately in fields such as particle physics, astrophysics, and medical physics. Its popularity stems from its lower cost, compact size, insensitivity to magnetic fields, and its excellent ability to distinguish a quantized number of photons. They are normally operated at room temperature and biased above their breakdown voltages. As such, they may also exhibit properties that may hinder their optimal operation which include a thermally induced high dark count rate, after pulse effects, and cross talk from photons in nearby pixels. At this poster session, we describe our data analysis and our endeavor to characterize the multipixel photon counter (MPPC) detectors from Hamamatsu under different bias voltages and temperature conditions. Particularly, we describe our setup which uses cosmic rays to induce scintillation light delivered to the detector by wavelength shifting optical fibers and the use of a fast 1 GHz waveform sampler, the domino ring sampler (DRS4) digitizer board. Department of Education grant number P031S90007.

Rigid thin windows for vacuum applications

Science.gov (United States)

Meyer, Glenn Allyn; Ciarlo, Dino R.; Myers, Booth Richard; Chen, Hao-Lin; Wakalopulos, George

1999-01-01

A thin window that stands off atmospheric pressure is fabricated using photolithographic and wet chemical etching techniques and comprises at least two layers: an etch stop layer and a protective barrier layer. The window structure also comprises a series of support ribs running the width of the window. The windows are typically made of boron-doped silicon and silicon nitride and are useful in instruments such as electron beam guns and x-ray detectors. In an electron beam gun, the window does not impede the electrons and has demonstrated outstanding gun performance and survivability during the gun tube manufacturing process.

Improvements in or relating to radiation detection arrangements

International Nuclear Information System (INIS)

Davis, G.P.

1977-01-01

A radiation detection arrangement is described that that comprises a number of scintillator devices, and a single multi-channel photomultiplier tube. Light from the scintillator devices is incident on the photocathode through an entrance window in the tube and multiplier entrance separating means are provided whereby light from each of the devices is made to be incident upon the channel entrances of photomultiplier tube. Various geometrical forms for the scintillator devices are described. This arrangement avoids the use of large number of small photomultiplier tubes, which is expensive and gives rise to difficulties in stacking the tubes in closely spaced side-by-side relationship. (U.K.)

Two-dimensional neutron scintillation detector with optimal gamma discrimination

International Nuclear Information System (INIS)

Kanyo, M.; Reinartz, R.; Schelten, J.; Mueller, K.D.

1993-01-01

The gamma sensitivity of a two-dimensional scintillation neutron detector based on position sensitive photomultipliers (Hamamatsu R2387 PM) has been minimized by a digital differential discrimination unit. Since the photomultiplier gain is position-dependent by ±25% a discrimination unit was developed where digital upper and lower discrimination levels are set due to the position-dependent photomultiplier gain obtained from calibration measurements. By this method narrow discriminator windows can be used to reduce the gamma background drastically without effecting the neutron sensitivity of the detector. The new discrimination method and its performance tested by neutron measurements will be described. Experimental results concerning spatial resolution and γ-sensitivity are presented

Performance evaluation of a sub-millimeter spatial resolution PET detector module using a digital silicon photomultiplier coupled LGSO array

Energy Technology Data Exchange (ETDEWEB)

Leem, Hyun Tae [Molecular Imaging Research & Education (MiRe) Laboratory, Department of Electronic Engineering, Sogang University, Seoul (Korea, Republic of); Choi, Yong, E-mail: ychoi@sogang.ac.kr [Molecular Imaging Research & Education (MiRe) Laboratory, Department of Electronic Engineering, Sogang University, Seoul (Korea, Republic of); Kim, Kyu Bom; Lee, Sangwon [Molecular Imaging Research & Education (MiRe) Laboratory, Department of Electronic Engineering, Sogang University, Seoul (Korea, Republic of); Yamamoto, Seiichi [Department of Medical Technology, Nagoya University Graduate School of Medicine, Nagoya (Japan); Yeom, Jung-Yeol, E-mail: jungyeol@korea.ac.kr [School of Biomedical Engineering, Korea University, Seoul (Korea, Republic of)

2017-02-21

In positron emission tomography (PET) for breast, brain and small animal imaging, the spatial resolution of a PET detector is crucial to obtain high quality PET images. In this study, a PET detector for sub-millimeter spatial resolution imaging purpose was assembled using 4×4 pixels of a digital silicon photomultiplier (dSiPM, DPC-3200-22-44, Philips) coupled with a 15×15 LGSO array with BaSO{sub 4} reflector, and a 1 mm thick acrylic light guide for light distribution between the dSiPM pixels. The active area of each dSiPM pixel was 3.2×3.9 mm{sup 2} and the size of each LGSO scintillator element was 0.7×0.7×6 mm{sup 3}. In this paper, we experimentally demonstrated the performance of the PET detector by measuring the energy resolution, 2D flood map, peak to valley (P/V) ratio, and coincidence resolving time (CRT). All measurements were performed at a temperature of 10±1 ℃. The average energy resolution was 15.6% (without correcting for saturation effects) at 511 keV and the best CRT was 242±5 ps. The 2D flood map obtained with an energy window of 400–600 keV demonstrated clear identification of all pixels, and the average P/V ratio of the X- and Y-directions were 7.31 and 7.81, respectively. This study demonstrated that the PET detector could be suitable for application in high resolution PET while achieving good timing resolution.

A new VME-based high voltage power supply for large photomultiplier systems

International Nuclear Information System (INIS)

Neumaier, S.; Hubbeling, T.; Kolb, B.W.; Purschke, M.L.; Ippolitov, M.; Blume, C.; Bohne, E.M.; Bucher, D.; Claussen, A.; Peitzmann, T.; Schepers, G.; Schlagheck, H.

1995-01-01

We describe a new high voltage power supply, developed for the leadglass calorimeter of the WA98 experiment at CERN. The high voltage is produced for each of the 10,080 photomultiplier tubes of the detector individually, by the same number of active bases with on-board Greinacher voltage multipliers. The full VME-based HV controller system, which addresses each base via bus cables once per second, is miniaturized and fits into a single VME crate. The main advantages of this approach are the low heat dissipation, the considerably reduced amount of cabling and cost, as well as the high stability and low noise of the system. (orig.)

Windows 8.1 for dummies

CERN Document Server

Rathbone, Andy

2013-01-01

The bestselling book on Windows, now updated for the new 8.1 features Microsoft has fine-tuned Windows 8 with some important new features, and veteran author Andy Rathbone explains every one in this all-new edition of a long-time bestseller. Whether you're using Windows for the first time, upgrading from an older version, or just moving from Windows 8 to 8.1, here's what you need to know. Learn about the dual interfaces, the new Start button, how to customize the interface and boot operations, and how to work with programs and files, use the web and social media, manage music and photos, and

Windows 7 the definitive guide

CERN Document Server

Stanek, William R

2010-01-01

This book provides everything you need to manage and maintain Windows 7. You'll learn all of the features and enhancements in complete detail, along with specifics for configuring the operating system to put you in full control. Bestselling author and Windows expert William Stanek doesn't just show you the steps you need to follow, he also tells you how features work, why they work, and how you can customize them to meet your needs. Learn how to squeeze every bit of power out of Windows 7 to take full advantage of its features and programs. Set up, customize, and tune Windows 7-Optimize its

Live histograms in moving windows

International Nuclear Information System (INIS)

Zhil'tsov, V.E.

1989-01-01

Application of computer graphics for specific hardware testing is discussed. The hardware is position sensitive detector (multiwire proportional chamber) which is used in high energy physics experiments, and real-out electronics for it. Testing program is described (XPERT), which utilises multi-window user interface. Data are represented as histograms in windows. The windows on the screen may be moved, reordered, their sizes may be changed. Histograms may be put to any window, and hardcopy may be made. Some program internals are discussed. The computer environment is quite simple: MS-DOS IBM PC/XT, 256 KB RAM, CGA, 5.25'' FD, Epson MX. 4 refs.; 7 figs

Measurement of the time resolution of small SiPM-based scintillation counters

Science.gov (United States)

Kravchenko, E. A.; Porosev, V. V.; Savinov, G. A.

2017-12-01

In this research, we evaluated the timing resolution of SiPM-based scintillation detector on a 1-GeV electron beam "extracted" from VEPP-4M. We tested small scintillation crystals of pure CsI, YAP, LYSO, and LFS-3 with HAMAMATSU S10362-33-025C and S13360-3050CS. The CsI scintillator together with HAMAMATSU S13360-3050CS demonstrated the best results. Nevertheless, the achieved time resolution of ~80 ps (RMS) relates mainly to the photodetector itself. It makes the silicon photomultiplier an attractive candidate to replace other devices in applications where sub-nanosecond accuracy is required.

Yapı Açısından Cümle Sorunu In Terms of Sentence Structure Problem

Directory of Open Access Journals (Sweden)

H. İbrahim DELİCE

2012-09-01

kullanılan sözcük veya sözcük öbeği dizisi' olması ve bir duygu, düşünce, hüküm vb. ifade etmesi' özellikleri esas alınarak tanımlanmaktadır. Cümlenin 'yargı' esaslı bu tanımı, cümle için doğru bir bakış açısını yansıtmamaktadır; çünkü, bir sözcük veya sözcük öbeği de cümle içinde yerine göre bir yargı ifade edebilir. Bir dizgeye cümle dememizi sağlayan en temel kavram 'yüklem'dir. Dolayısıyla, “Cümle, bir yüklem ile ona bağlı en az bir tamamlayıcıdan oluşan ve bir oluş, kılış ile durum bildiren söz dizim biçiminin adıdır.” şeklinde tanımlandığında 'yapı bakımından cümle' konusunda bizi doğruya götürebilecek başka bir açıdan bakmamız mümkün olabilecektir. Yüklem etrafında tamamlayıcı cümle öğelerinin eklenmesiyle oluşturulan cümle, eğer başka bir yüklemin yapısal öğesi olmuyorsa iki yüklemli dizgeyi bir cümle saymak doğru olmaz; zira, her iki dizgenin de öğe çözümlemesi ayrı ayrı yapılır. Bir kılış, oluş veya durum bir yüklem etrafında ifade edildikten sonra başka bir cümleyle birbirini takip eden zaman çizgisi doğrultusunda sıralama bağlaçları veya noktalama işaretleriyle sıralanarak ya da bir cümle başka bir cümleyle bağlama edatları vasıtasıyla ilişkilendirilerek yan yana dizilebilir. Anlamca birbirinin tamamlayıcısı olmasına rağmen yapısal açıdan bakıldığında ayrı birer cümle olan bu dizgeleri bir birleşik cümle saymak doğru değildir. Sonuç olarak bir yüklem etrafında oluşturulan dizge için 'yapmak' dolayısıyla 'yapı'; iki yüklem etrafında ayrı ayrı yapılmış dizgeleri bir amaç veya anlam doğrultusunda kurgulamak için 'kullanmak' dolayısıyla 'kullanım' sözcüklerinin benimsenmesi ile cümle tanımına aykırı cümle tasniflerinin ortaya çıkması önlenmiş; var olan cümle tasniflerindeki çelişki giderilmiş olacaktır.

Stochastic background of gravitational waves from hybrid preheating.

Science.gov (United States)

García-Bellido, Juan; Figueroa, Daniel G

2007-02-09

The process of reheating the Universe after hybrid inflation is extremely violent. It proceeds through the nucleation and subsequent collision of large concentrations of energy density in bubblelike structures, which generate a significant fraction of energy in the form of gravitational waves. We study the power spectrum of the stochastic background of gravitational waves produced at reheating after hybrid inflation. We find that the amplitude could be significant for high-scale models, although the typical frequencies are well beyond what could be reached by planned gravitational wave observatories. On the other hand, low-scale models could still produce a detectable stochastic background at frequencies accessible to those detectors. The discovery of such a background would open a new window into the very early Universe.

Working with Windows 7 at CERN (EN)

CERN Multimedia

CERN. Geneva

2010-01-01

Overview of new concepts and user interface changes in Windows 7 as compared with older versions of Windows: XP or Vista. Availability of Windows 7 at CERN and its integration with CERN Windows infrastructure will be discussed.

The LUCID-2 Detector

CERN Document Server

Soluk, Richard; The ATLAS collaboration

2017-01-01

The LUCID-2 detector is the main online and offline luminosity provider of the ATLAS experiment. It provides over 100 different luminosity measurements from different algorithms for each of the 2808 LHC bunches. LUCID was entirely redesigned in preparation for LHC Run 2: both the detector and the electronics were upgraded in order to cope with the challenging conditions expected at the LHC center of mass energy of 13 TeV with only 25 ns bunch-spacing. While LUCID-1 used gas as a Cherenkov medium, the LUCID-2 detector is in a new unique way using the quartz windows of small photomultipliers as the Cherenkov medium. The main challenge for a luminometer is to keep the efficiency constant during years of data-taking. LUCID-2 is using an innovative calibration system based on radioactive 207 Bi sources deposited on the quartz window of the readout photomultipliers. This makes it possible to accurately monitor and control the gain of the photomultipliers so that the detector efficiency can be kept stable at a perce...

LUCID-2: The ATLAS Luminometer

CERN Document Server

Cabras, Grazia; The ATLAS collaboration

2017-01-01

The LUCID-2 detector is the main online and offline luminosity provider of the ATLAS experiment. It provides over 100 different luminosity measurements from different algorithms for each of the 2808 LHC bunches. LUCID was entirely redesigned in preparation for LHC Run 2: both the detector and the electronics were upgraded in order to cope with the challenging conditions expected at the LHC center of mass energy of 13 TeV with only 25 ns bunch-spacing. While LUCID-1 used gas as a Cherenkov medium, the LUCID-2 detector is in a new unique way using the quartz windows of small photomultipliers as the Cherenkov medium. The main challenge for a luminometer is to keep the efficiency constant during years of data-taking. LUCID-2 is using an innovative calibration system based on radioactive 207 Bi sources deposited on the quartz window of the readout photomultipliers. This makes it possible to accurately monitor and control the gain of the photomultipliers so that the detector efficiency can be kept stable at a perce...