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Sample records for won joonhong lim

  1. WIST: toolkit for rapid, customized LIMS development

    National Research Council Canada - National Science Library

    Huang, Y Wayne; Arkin, Adam P; Chandonia, John-Marc

    2011-01-01

    Workflow Information Storage Toolkit (WIST) is a set of application programming interfaces and web applications that allow for the rapid development of customized laboratory information management systems (LIMS...

  2. Galaxy LIMS for next-generation sequencing

    NARCIS (Netherlands)

    Scholtalbers, J.; Rossler, J.; Sorn, P.; Graaf, J. de; Boisguerin, V.; Castle, J.; Sahin, U.

    2013-01-01

    SUMMARY: We have developed a laboratory information management system (LIMS) for a next-generation sequencing (NGS) laboratory within the existing Galaxy platform. The system provides lab technicians standard and customizable sample information forms, barcoded submission forms, tracking of input

  3. Balassa-Samuelson Effect in Won/Dollar and Won/Yen Exchange Rates

    Directory of Open Access Journals (Sweden)

    Donghwan Oh

    2010-06-01

    Full Text Available This paper examines, using various models including a non-linear one, that the Balassa-Samuelson (BS effect can account for the persistence of deviations from PPP in the long-run movements of won/dollar and won/yen real exchange rates. In test for PPP hypothesis that incorporates the BS effect, using the generalized Johansen' cointegration method, it is found that a cointegration relationship exists between each of won/dollar and won/yen real exchange rate and the productivity variables of two countries. And in test for PPP hypothesis that incorporates other fundamentals such as cumulative current account balance, foreign exchange reserve, terms of trade as well as productivity differentials, using a behavioral equilibrium exchange rate approach, it is found that a cointegration relationship exists between each of won/dollar and won/yen real exchange rate and all of these fundamentals. However, the plus sign of the estimated coefficient of the productivity differentials variable, which means that domestic productivity improvement produces increase in each of won/dollar and won/yen real exchange rate is not coincident with the result that the BS effect expects theoretically. Finally, in test for PPP hypothesis that incorporates the BS effect, using a non-linear STAR model, it is found that the adjustment process in case of won/dollar real exchange rate from the long-run equilibrium level can be adequately explained by a non-linear LSTAR model. But, the evidence of diagnostic statistics, which shows the existence of autocorrelation of the residuals in most of lags, might suggest the inadequacy of LSTAR model specification.

  4. LIMS Version 6 Level 3 Dataset

    Science.gov (United States)

    Remsberg, Ellis E.; Lingenfelser, Gretchen

    2010-01-01

    This report describes the Limb Infrared Monitor of the Stratosphere (LIMS) Version 6 (V6) Level 3 data products and the assumptions used for their generation. A sequential estimation algorithm was used to obtain daily, zonal Fourier coefficients of the several parameters of the LIMS dataset for 216 days of 1978-79. The coefficients are available at up to 28 pressure levels and at every two degrees of latitude from 64 S to 84 N and at the synoptic time of 12 UT. Example plots were prepared and archived from the data at 10 hPa of January 1, 1979, to illustrate the overall coherence of the features obtained with the LIMS-retrieved parameters.

  5. Laboratory automation and LIMS in forensics

    DEFF Research Database (Denmark)

    Stangegaard, Michael; Hansen, Anders Johannes; Morling, Niels

    2013-01-01

    Implementation of laboratory automation and LIMS in a forensic laboratory enables the laboratory, to standardize sample processing. Automated liquid handlers can increase throughput and eliminate manual repetitive pipetting operations, known to result in occupational injuries to the technical staff....... Furthermore, implementation of automated liquid handlers reduces the risk of sample misplacement. A LIMS can efficiently control the sample flow through the laboratory and manage the results of the conducted tests for each sample. Integration of automated liquid handlers with a LIMS provides the laboratory...... with the tools required for setting up automated production lines of complex laboratory processes and monitoring the whole process and the results. Combined, this enables processing of a large number of samples. Selection of the best automated solution for an individual laboratory should be based on user...

  6. Improving the Plasticity of LIMS Implementation: LIMS Extension through Microsoft Excel

    Science.gov (United States)

    Culver, Mark

    2017-01-01

    A Laboratory Information Management System (LIMS) is a databasing software with many built-in tools ideal for handling and documenting most laboratory processes in an accurate and consistent manner, making it an indispensable tool for the modern laboratory. However, a lot of LIMS end users will find that in the performance of analyses that have unique considerations such as standard curves, multiple stages incubations, or logical considerations, a base LIMS distribution may not ideally suit their needs. These considerations bring about the need for extension languages, which can extend the functionality of a LIMS. While these languages do provide the implementation team the functionality required to accommodate these special laboratory analyses, they are usually too complex for the end user to modify to compensate for natural changes in laboratory operations. The LIMS utilized by our laboratory offers a unique and easy-to-use choice for an extension language, one that is already heavily relied upon not only in science but also in most academic and business pursuits: Microsoft Excel. The validity of Microsoft Excel as a pseudo programming language and its usability and versatility as a LIMS extension language will be discussed. The NELAC implications and overall drawbacks of this LIMS configuration will also be discussed.

  7. Comparing sea ice, hydrography and circulation between NEMO3.6 LIM3 and LIM2

    Science.gov (United States)

    Uotila, Petteri; Iovino, Doroteaciro; Vancoppenolle, Martin; Lensu, Mikko; Rousset, Clement

    2017-03-01

    A set of hindcast simulations with the new version 3.6 of the Nucleus for European Modelling of the Ocean (NEMO) ocean-ice model in the ORCA1 configuration and forced by the DRAKKAR Forcing Set version 5.2 (DFS5.2) atmospheric data was performed from 1958 to 2012. Simulations differed in their sea-ice component: the old standard version Louvain-la-Neuve Sea Ice Model (LIM2) and its successor LIM3. Main differences between these sea-ice models are the parameterisations of sub-grid-scale sea-ice thickness distribution, ice deformation, thermodynamic processes, and sea-ice salinity. Our main objective was to analyse the response of the ocean-ice system sensitivity to the change in sea-ice physics. Additional sensitivity simulations were carried out for the attribution of observed differences between the two main simulations.In the Arctic, NEMO-LIM3 compares better with observations by realistically reproducing the sea-ice extent decline during the last few decades due to its multi-category sea-ice thickness. In the Antarctic, NEMO-LIM3 more realistically simulates the seasonal evolution of sea-ice extent than NEMO-LIM2. In terms of oceanic properties, improvements are not as evident, although NEMO-LIM3 reproduces a more realistic hydrography in the Labrador Sea and in the Arctic Ocean, including a reduced cold temperature bias of the Arctic Intermediate Water at 250 m. In the extra-polar regions, the oceanographic conditions of the two NEMO-LIM versions remain relatively similar, although they slowly drift apart over decades. This drift is probably due to a stronger deep water formation around Antarctica in LIM3.

  8. LIM e pratiche di insegnamento: quali sfide per la valutazione?

    Directory of Open Access Journals (Sweden)

    Simonetta Leonardi

    2013-03-01

    Full Text Available Il contributo affronta il tema del rapporto tra le pratiche di uso della LIM e i metodi di valutazione. Partendo dalla presentazione di una specifica esperienza e sottolineando il legame con il tema della motivazione, si presentano modalità di uso della LIM che portano alla percezione di interventi efficaci da parte del docente. In tal senso un approccio di natura empirica può costituire il primo passo verso la valutazione dell’uso della LIM.

  9. La LIM in classe: un catalogo possibile

    Directory of Open Access Journals (Sweden)

    Teresa Magnaterra

    2013-03-01

    Full Text Available L’articolo propone un bilancio provvisorio dell’esperienza dell’autrice come tutor in corsi di formazione all’uso della LIM per docenti di scuola primaria e secondaria di I grado. La metodologia scelta è quella di costruire classificazioni sulla base di criteri e punti di vista differenti, che sono emersi durante i percorsi di formazione e sono stati discussi e condivisi con i docenti. Lo scopo è quello di individuare una serie di pratiche didattiche da attivare in classe in modo mirato e consapevole. L’impatto che la lavagna interattiva multimediale ha avuto fra gli insegnanti ha prodotto reazioni di entusiasmo e anche di rinuncia; ha coltivato però, fra gli stessi insegnanti, l’esigenza, e in alcuni casi la necessità, di rivedere non solo il rapporto con gli strumenti da adottare, ma anche con l’intera impostazione didattica. La sfida dunque è duplice: da una parte gli insegnanti cercano di imparare a usare la LIM, dall’altra essi, anche attraverso la lavagna interattiva, possono esplorare percorsi didattici che promuovano un apprendimento critico e creativo.

  10. Laboratory Information Management System (LIMS): A case study

    Science.gov (United States)

    Crandall, Karen S.; Auping, Judith V.; Megargle, Robert G.

    1987-01-01

    In the late 70's, a refurbishment of the analytical laboratories serving the Materials Division at NASA Lewis Research Center was undertaken. As part of the modernization efforts, a Laboratory Information Management System (LIMS) was to be included. Preliminary studies indicated a custom-designed system as the best choice in order to satisfy all of the requirements. A scaled down version of the original design has been in operation since 1984. The LIMS, a combination of computer hardware, provides the chemical characterization laboratory with an information data base, a report generator, a user interface, and networking capabilities. This paper is an account of the processes involved in designing and implementing that LIMS.

  11. LimsPortal and BonsaiLIMS: development of a lab information management system for translational medicine

    OpenAIRE

    Bath, Timothy G; Bozdag, Selcuk; Afzal, Vackar; Crowther, Daniel

    2011-01-01

    Abstract Background Laboratory Information Management Systems (LIMS) are an increasingly important part of modern laboratory infrastructure. As typically very sophisticated software products, LIMS often require considerable resources to select, deploy and maintain. Larger organisations may have access to specialist IT support to assist with requirements elicitation and software customisation, however smaller groups will often have limited IT support to perform the kind of iterative developmen...

  12. The LIM Homeodomain Transcription Factor LHX6

    Science.gov (United States)

    Zhang, Zichao; Gutierrez, Diana; Li, Xiao; Bidlack, Felicitas; Cao, Huojun; Wang, Jianbo; Andrade, Kelsey; Margolis, Henry C.; Amendt, Brad A.

    2013-01-01

    LHX6 is a LIM-homeobox transcription factor expressed during embryogenesis; however, the molecular mechanisms regulating LHX6 transcriptional activities are unknown. LHX6 and the PITX2 homeodomain transcription factor have overlapping expression patterns during tooth and craniofacial development, and in this report, we demonstrate new transcriptional mechanisms for these factors. PITX2 and LHX6 are co-expressed in the oral and dental epithelium and epithelial cell lines. Lhx6 expression is increased in Pitx2c transgenic mice and decreased in Pitx2 null mice. PITX2 activates endogenous Lhx6 expression and the Lhx6 promoter, whereas LHX6 represses its promoter activity. Chromatin immunoprecipitation experiments reveal endogenous PITX2 binding to the Lhx6 promoter. LHX6 directly interacts with PITX2 to inhibit PITX2 transcriptional activities and activation of multiple promoters. Bimolecular fluorescence complementation assays reveal an LHX6·PITX2 nuclear interaction in living cells. LHX6 has a dominant repressive effect on the PITX2 synergistic activation with LEF-1 and β-catenin co-factors. Thus, LHX6 acts as a transcriptional repressor and represses the expression of several genes involved in odontogenesis. We have identified specific defects in incisor, molar, mandible, bone, and root development and late stage enamel formation in Lhx6 null mice. Amelogenin and ameloblastin expression is reduced and/or delayed in the Lhx6 null mice, potentially resulting from defects in dentin deposition and ameloblast differentiation. Our results demonstrate that LHX6 regulates cell proliferation in the cervical loop and promotes cell differentiation in the anterior region of the incisor. We demonstrate new molecular mechanisms for LHX6 and an interaction with PITX2 for normal craniofacial and tooth development. PMID:23229549

  13. College Students Discount Money "Won" More than Money "Owed"

    Science.gov (United States)

    Weatherly, Jeffrey N.; Derenne, Adam; Terrell, Heather K.

    2010-01-01

    Evidence in the research literature indicates people may treat "won" money differently than they would their own money. The present study had a sample of 648 college students complete a delay-discounting task that involved the hypothetical monetary amounts of $1,000 or $100,000. Participants were asked repeatedly what amount they would…

  14. Why Bright College Students Won't Teach.

    Science.gov (United States)

    Berry, Barnett

    1986-01-01

    For the brightest students the most significant reasons why they won't teach relate to frustrating working conditions, bureaucratic requirements, the lack of professional control, and few opportunities for intellectual growth, as well as these students' intolerance for diversity in the workplace and their perception of teaching as a "boring…

  15. An amphioxus LIM-homeobox gene, AmphiLim1/5, expressed early in the invaginating organizer region and later in differentiating cells of the kidney and central nervous system

    OpenAIRE

    James A. Langeland, Linda Z. Holland, Roger A. Chastain, Nicholas D. Holland

    2006-01-01

    A LIM-homeobox gene, AmphiLim1/5, from the Florida amphioxus (Branchiostoma floridae) encodes a protein that phylogenetic analysis positions at the base of a clade comprising vertebrate Lim1 and Lim5. Amphioxus AmphiLim1/5 is expressed in domains that are a composite of those of vertebrate Lim1 and Lim5, which evidently underwent subfunctionalization after duplication of an ancestral protochordate Lim1/5. During amphioxus development, transcription is first detected in the ectoderm of the bla...

  16. LimsPortal and BonsaiLIMS: development of a lab information management system for translational medicine

    Directory of Open Access Journals (Sweden)

    Afzal Vackar

    2011-05-01

    Full Text Available Abstract Background Laboratory Information Management Systems (LIMS are an increasingly important part of modern laboratory infrastructure. As typically very sophisticated software products, LIMS often require considerable resources to select, deploy and maintain. Larger organisations may have access to specialist IT support to assist with requirements elicitation and software customisation, however smaller groups will often have limited IT support to perform the kind of iterative development that can resolve the difficulties that biologists often have when specifying requirements. Translational medicine aims to accelerate the process of treatment discovery by bringing together multiple disciplines to discover new approaches to treating disease, or novel applications of existing treatments. The diverse set of disciplines and complexity of processing procedures involved, especially with the use of high throughput technologies, bring difficulties in customizing a generic LIMS to provide a single system for managing sample related data within a translational medicine research setting, especially where limited IT support is available. Results We have designed and developed a LIMS, BonsaiLIMS, around a very simple data model that can be easily implemented using a variety of technologies, and can be easily extended as specific requirements dictate. A reference implementation using Oracle 11 g database and the Python framework, Django is presented. Conclusions By focusing on a minimal feature set and a modular design we have been able to deploy the BonsaiLIMS system very quickly. The benefits to our institute have been the avoidance of the prolonged implementation timescales, budget overruns, scope creep, off-specifications and user fatigue issues that typify many enterprise software implementations. The transition away from using local, uncontrolled records in spreadsheet and paper formats to a centrally held, secured and backed-up database brings the

  17. LimsPortal and BonsaiLIMS: development of a lab information management system for translational medicine.

    Science.gov (United States)

    Bath, Timothy G; Bozdag, Selcuk; Afzal, Vackar; Crowther, Daniel

    2011-05-13

    Laboratory Information Management Systems (LIMS) are an increasingly important part of modern laboratory infrastructure. As typically very sophisticated software products, LIMS often require considerable resources to select, deploy and maintain. Larger organisations may have access to specialist IT support to assist with requirements elicitation and software customisation, however smaller groups will often have limited IT support to perform the kind of iterative development that can resolve the difficulties that biologists often have when specifying requirements. Translational medicine aims to accelerate the process of treatment discovery by bringing together multiple disciplines to discover new approaches to treating disease, or novel applications of existing treatments. The diverse set of disciplines and complexity of processing procedures involved, especially with the use of high throughput technologies, bring difficulties in customizing a generic LIMS to provide a single system for managing sample related data within a translational medicine research setting, especially where limited IT support is available. We have designed and developed a LIMS, BonsaiLIMS, around a very simple data model that can be easily implemented using a variety of technologies, and can be easily extended as specific requirements dictate. A reference implementation using Oracle 11 g database and the Python framework, Django is presented. By focusing on a minimal feature set and a modular design we have been able to deploy the BonsaiLIMS system very quickly. The benefits to our institute have been the avoidance of the prolonged implementation timescales, budget overruns, scope creep, off-specifications and user fatigue issues that typify many enterprise software implementations. The transition away from using local, uncontrolled records in spreadsheet and paper formats to a centrally held, secured and backed-up database brings the immediate benefits of improved data visibility, audit and

  18. Expression analysis of LIM gene family in poplar, toward an updated phylogenetic classification

    Directory of Open Access Journals (Sweden)

    Arnaud Dominique

    2012-02-01

    Full Text Available Abstract Background Plant LIM domain proteins may act as transcriptional activators of lignin biosynthesis and/or as actin binding and bundling proteins. Plant LIM genes have evolved in phylogenetic subgroups differing in their expression profiles: in the whole plant or specifically in pollen. However, several poplar PtLIM genes belong to uncharacterized monophyletic subgroups and the expression patterns of the LIM gene family in a woody plant have not been studied. Findings In this work, the expression pattern of the twelve duplicated poplar PtLIM genes has been investigated by semi quantitative RT-PCR in different vegetative and reproductive tissues. As in other plant species, poplar PtLIM genes were widely expressed in the tree or in particular tissues. Especially, PtXLIM1a, PtXLIM1b and PtWLIM1b genes were preferentially expressed in the secondary xylem, suggesting a specific function in wood formation. Moreover, the expression of these genes and of the PtPLIM2a gene was increased in tension wood. Western-blot analysis confirmed the preferential expression of PtXLIM1a protein during xylem differentiation and tension wood formation. Genes classified within the pollen specific PLIM2 and PLIM2-like subgroups were all strongly expressed in pollen but also in cottony hairs. Interestingly, pairs of duplicated PtLIM genes exhibited different expression patterns indicating subfunctionalisations in specific tissues. Conclusions The strong expression of several LIM genes in cottony hairs and germinating pollen, as well as in xylem fibers suggests an involvement of plant LIM domain proteins in the control of cell expansion. Comparisons of expression profiles of poplar LIM genes with the published functions of closely related plant LIM genes suggest conserved functions in the areas of lignin biosynthesis, pollen tube growth and mechanical stress response. Based on these results, we propose a novel nomenclature of poplar LIM domain proteins.

  19. Sustainable Land Management in the Lim River Basin

    Science.gov (United States)

    Grujic, Gordana; Petkovic, Sava; Tatomir, Uros

    2017-04-01

    In the cross-border belt between Serbia and Montenegro are located more than one hundred torrential water flows that belong to the Lim River Basin. Under extreme climate events they turned into floods of destructive power and great energy causing enormous damage on the environment and socio-economic development in the wider region of the Western Balkans. In addition, anthropogenic factors influence the land instability, erosion of river beds and loss of topsoil. Consequently, this whole area is affected by pluvial and fluvial erosion of various types and intensity. Terrain on the slopes over 5% is affected by intensive degree of erosion, while strong to medium degree covers 70% of the area. Moreover, in the Lim River Basin were built several hydro-energetic systems and accumulations which may to a certain extent successfully regulate the water regime downstream and to reduce the negative impact on the processes of water erosion. However, siltation of accumulation reduces their useful volume and threatens the basic functions (water reservoirs), especially those ones for water supply, irrigation and energy production that have lost a significant part of the usable volume due to accumulated sediments. Facing the negative impacts of climate change and human activities on the process of land degradation in the Lim River basin imposes urgent need of adequate preventive and protective measures at the local and regional level, which can be effectively applied only through enhanced cross-border cooperation among affected communities in the region. The following set of activities were analyzed to improve the actual management of river catchment: Identifying priorities in the spatial planning, land use and water resources management while respecting the needs of local people and the communities in the cross border region; development of cooperation and partnership between the local population, owners and users of real estate (pastures, agricultural land, forests, fisheries

  20. 47 CFR 90.811 - Reduced down payment for licenses won by small businesses.

    Science.gov (United States)

    2010-10-01

    ... SPECIAL RADIO SERVICES PRIVATE LAND MOBILE RADIO SERVICES Competitive Bidding Procedures for 900 MHz Specialized Mobile Radio Service § 90.811 Reduced down payment for licenses won by small businesses. Each... 47 Telecommunication 5 2010-10-01 2010-10-01 false Reduced down payment for licenses won by small...

  1. MetaLIMS, a simple open-source laboratory information management system for small metagenomic labs.

    Science.gov (United States)

    Heinle, Cassie Elizabeth; Gaultier, Nicolas Paul Eugène; Miller, Dana; Purbojati, Rikky Wenang; Lauro, Federico M

    2017-06-01

    As the cost of sequencing continues to fall, smaller groups increasingly initiate and manage larger sequencing projects and take on the complexity of data storage for high volumes of samples. This has created a need for low-cost laboratory information management systems (LIMS) that contain flexible fields to accommodate the unique nature of individual labs. Many labs do not have a dedicated information technology position, so LIMS must also be easy to setup and maintain with minimal technical proficiency. MetaLIMS is a free and open-source web-based application available via GitHub. The focus of MetaLIMS is to store sample metadata prior to sequencing and analysis pipelines. Initially designed for environmental metagenomics labs, in addition to storing generic sample collection information and DNA/RNA processing information, the user can also add fields specific to the user's lab. MetaLIMS can also produce a basic sequencing submission form compatible with the proprietary Clarity LIMS system used by some sequencing facilities. To help ease the technical burden associated with web deployment, MetaLIMS options the use of commercial web hosting combined with MetaLIMS bash scripts for ease of setup. MetaLIMS overcomes key challenges common in LIMS by giving labs access to a low-cost and open-source tool that also has the flexibility to meet individual lab needs and an option for easy deployment. By making the web application open source and hosting it on GitHub, we hope to encourage the community to build upon MetaLIMS, making it more robust and tailored to the needs of more researchers.

  2. openBIS ELN-LIMS: an open-source database for academic laboratories.

    Science.gov (United States)

    Barillari, Caterina; Ottoz, Diana S M; Fuentes-Serna, Juan Mariano; Ramakrishnan, Chandrasekhar; Rinn, Bernd; Rudolf, Fabian

    2016-02-15

    The open-source platform openBIS (open Biology Information System) offers an Electronic Laboratory Notebook and a Laboratory Information Management System (ELN-LIMS) solution suitable for the academic life science laboratories. openBIS ELN-LIMS allows researchers to efficiently document their work, to describe materials and methods and to collect raw and analyzed data. The system comes with a user-friendly web interface where data can be added, edited, browsed and searched. The openBIS software, a user guide and a demo instance are available at https://openbis-eln-lims.ethz.ch. The demo instance contains some data from our laboratory as an example to demonstrate the possibilities of the ELN-LIMS (Ottoz et al., 2014). For rapid local testing, a VirtualBox image of the ELN-LIMS is also available. © The Author 2015. Published by Oxford University Press.

  3. Molecular Characterization of abLIM, a Novel Actin-binding and Double Zinc Finger Protein

    Science.gov (United States)

    Roof, Dorothy J.; Hayes, Annmarie; Adamian, Michael; Chishti, Athar H.; Li, Tiansen

    1997-01-01

    Molecules that couple the actin-based cytoskeleton to intracellular signaling pathways are central to the processes of cellular morphogenesis and differentiation. We have characterized a novel protein, the actin-binding LIM (abLIM) protein, which could mediate such interactions between actin filaments and cytoplasmic targets. abLIM protein consists of a COOH-terminal cytoskeletal domain that is fused to an NH2-terminal domain consisting of four double zinc finger motifs. The cytoskeletal domain is ∼50% identical to erythrocyte dematin, an actin-bundling protein of the red cell membrane skeleton, while the zinc finger domains conform to the LIM motif consensus sequence. In vitro expression studies demonstrate that abLIM protein can bind to F-actin through the dematin-like domain. Transcripts corresponding to three distinct isoforms have a widespread tissue distribution. However, a polypeptide corresponding to the full-length isoform is found exclusively in the retina and is enriched in biochemical extracts of retinal rod inner segments. abLIM protein also undergoes extensive phosphorylation in light-adapted retinas in vivo, and its developmental expression in the retina coincides with the elaboration of photoreceptor inner and outer segments. Based on the composite primary structure of abLIM protein, actin-binding capacity, potential regulation via phosphorylation, and isoform expression pattern, we speculate that abLIM may play a general role in bridging the actin-based cytoskeleton with an array of potential LIM protein-binding partners. The developmental time course of abLIM expression in the retina suggests that the retina-specific isoform may have a specialized role in the development or elaboration of photoreceptor inner and outer segments. PMID:9245787

  4. Early evolution of the LIM homeobox gene family

    Energy Technology Data Exchange (ETDEWEB)

    Srivastava, Mansi; Larroux, Claire; Lu, Daniel R; Mohanty, Kareshma; Chapman, Jarrod; Degnan, Bernard M; Rokhsar, Daniel S

    2010-01-01

    LIM homeobox (Lhx) transcription factors are unique to the animal lineage and have patterning roles during embryonic development in flies, nematodes and vertebrates, with a conserved role in specifying neuronal identity. Though genes of this family have been reported in a sponge and a cnidarian, the expression patterns and functions of the Lhx family during development in non-bilaterian phyla are not known. We identified Lhx genes in two cnidarians and a placozoan and report the expression of Lhx genes during embryonic development in Nematostella and the demosponge Amphimedon. Members of the six major LIM homeobox subfamilies are represented in the genomes of the starlet sea anemone, Nematostella vectensis, and the placozoan Trichoplax adhaerens. The hydrozoan cnidarian, Hydra magnipapillata, has retained four of the six Lhx subfamilies, but apparently lost two others. Only three subfamilies are represented in the haplosclerid demosponge Amphimedon queenslandica. A tandem cluster of three Lhx genes of different subfamilies and a gene containing two LIM domains in the genome of T. adhaerens (an animal without any neurons) indicates that Lhx subfamilies were generated by tandem duplication. This tandem cluster in Trichoplax is likely a remnant of the original chromosomal context in which Lhx subfamilies first appeared. Three of the six Trichoplax Lhx genes are expressed in animals in laboratory culture, as are all Lhx genes in Hydra. Expression patterns of Nematostella Lhx genes correlate with neural territories in larval and juvenile polyp stages. In the aneural demosponge, A. queenslandica, the three Lhx genes are expressed widely during development, including in cells that are associated with the larval photosensory ring. The Lhx family expanded and diversified early in animal evolution, with all six subfamilies already diverged prior to the cnidarian-placozoan-bilaterian last common ancestor. In Nematostella, Lhx gene expression is correlated with neural

  5. Early evolution of the LIM homeobox gene family

    Directory of Open Access Journals (Sweden)

    Degnan Bernard M

    2010-01-01

    Full Text Available Abstract Background LIM homeobox (Lhx transcription factors are unique to the animal lineage and have patterning roles during embryonic development in flies, nematodes and vertebrates, with a conserved role in specifying neuronal identity. Though genes of this family have been reported in a sponge and a cnidarian, the expression patterns and functions of the Lhx family during development in non-bilaterian phyla are not known. Results We identified Lhx genes in two cnidarians and a placozoan and report the expression of Lhx genes during embryonic development in Nematostella and the demosponge Amphimedon. Members of the six major LIM homeobox subfamilies are represented in the genomes of the starlet sea anemone, Nematostella vectensis, and the placozoan Trichoplax adhaerens. The hydrozoan cnidarian, Hydra magnipapillata, has retained four of the six Lhx subfamilies, but apparently lost two others. Only three subfamilies are represented in the haplosclerid demosponge Amphimedon queenslandica. A tandem cluster of three Lhx genes of different subfamilies and a gene containing two LIM domains in the genome of T. adhaerens (an animal without any neurons indicates that Lhx subfamilies were generated by tandem duplication. This tandem cluster in Trichoplax is likely a remnant of the original chromosomal context in which Lhx subfamilies first appeared. Three of the six Trichoplax Lhx genes are expressed in animals in laboratory culture, as are all Lhx genes in Hydra. Expression patterns of Nematostella Lhx genes correlate with neural territories in larval and juvenile polyp stages. In the aneural demosponge, A. queenslandica, the three Lhx genes are expressed widely during development, including in cells that are associated with the larval photosensory ring. Conclusions The Lhx family expanded and diversified early in animal evolution, with all six subfamilies already diverged prior to the cnidarian-placozoan-bilaterian last common ancestor. In

  6. con trastornos de personalidad limítrofe

    Directory of Open Access Journals (Sweden)

    Claudio Martínez Guzmán

    2005-01-01

    Full Text Available A partir de una experiencia de trabajo e investigación con pacientes en crisis dentro de servicios de urgencia psiquiátricos y de hospital general se proponen ideas acerca del abordaje de la patología de personalidad limítrofe en ese contexto. Se exploran algunas ideas sobre las particularidades del llamado parasuicidio del paciente límite y se describen elementos que deberían abordarse en una intervención de esta naturaleza y que constituyen variantes en la modalidad estándar de esta clase de terapia. Se discute acerca del tema de la dosis-efecto en la psicoterapia y se propone esta técnica como puerta de entrada en servicios masivos de atención psicológica

  7. The Many Sides of Happy Lim: aka Hom Ah Wing, Lin Jian Fu, Happy Lum, Lin Chien Fu, Hom Yen Chuck, Lam Kin Foo, Lum Kin Foo, Hom, Lim Goon Wing, Lim Gin Foo, Gin Foo Lin, Koon Wing Lim, Henry Chin, Lim Ying Chuck, Lim Ah Wing, et. al.

    Directory of Open Access Journals (Sweden)

    Gordon H. Chang

    2010-03-01

    Full Text Available

    Known to the FBI, INS, and IRS as Mr. Ah Wing Hom, he was also Lin Jian Fu, Jian Fu (Tough Guy, or just Fu to the readers of the many poems and short stories he published in Chinese over four decades in the twentieth century. And to still others, primarily English-readers of his writing, he was Happy Lim, an ironic, even tragically bizarre name, as his life was far from pleasant. On New Year's Day 1986, he died alone in a dingy San Francisco Chinatown bachelor hotel suffering from a bacterial infection and a chronic blood disorder that had required the amputation of all his toes the year before. He was seventy-eight years of age and had spent most of his life within blocks of where he died.

  8. The Many Sides of Happy Lim: aka Hom Ah Wing, Lin Jian Fu, Happy Lum, Lin Chien Fu, Hom Yen Chuck, Lam Kin Foo, Lum Kin Foo, Hom, Lim Goon Wing, Lim Gin Foo, Gin Foo Lin, Koon Wing Lim, Henry Chin, Lim Ying Chuck, Lim Ah Wing, et. al.

    Directory of Open Access Journals (Sweden)

    Gordon H. Chang

    2010-03-01

    Full Text Available Known to the FBI, INS, and IRS as Mr. Ah Wing Hom, he was also Lin Jian Fu, Jian Fu (Tough Guy, or just Fu to the readers of the many poems and short stories he published in Chinese over four decades in the twentieth century. And to still others, primarily English-readers of his writing, he was Happy Lim, an ironic, even tragically bizarre name, as his life was far from pleasant. On New Year's Day 1986, he died alone in a dingy San Francisco Chinatown bachelor hotel suffering from a bacterial infection and a chronic blood disorder that had required the amputation of all his toes the year before. He was seventy-eight years of age and had spent most of his life within blocks of where he died.

  9. The Role of Private Information in Short-term Fluctuations of Won/Dollar Exchange Rates

    Directory of Open Access Journals (Sweden)

    Haesik Park

    1999-12-01

    Full Text Available In this paper, we have examined the short-run movement of the won/dollar exchange rate using information obtained from the inter-bank market in Korea. First, we constructed the hourly measure of excess demand for dollar and used it as a proxy for the trading pattern of market participants. To construct this time series, we relied on the bid and ask won/dollar exchange rates collected on the two-minute interval. We then estimated the structural VAR model consisting of the actually observed won/dollar exchange rate and the proxied trading pattern of market participants to see if private information, as opposed to public information, is relevant for explaining the hourly movement of the won/dollar exchange rate. Private information is found to account for more 30% of hourly variations of the won/dollar exchange rate. Next, we constructed the trading pattern of market participants on a daily basis using the same data set employed to build the hourly measure. We then examined whether private information is useful for predicting the daily won/dollar exchange rate movement. We found that the forecast model using both private and public information reduces out-of-sample forecast errors of an alternative model relying only on public information by 20~25%. Also, the out-of-sample forecast of the model using both private and public information is found to be more accurate than the random walk model.

  10. Leaf LIMS: A Flexible Laboratory Information Management System with a Synthetic Biology Focus.

    Science.gov (United States)

    Craig, Thomas; Holland, Richard; D'Amore, Rosalinda; Johnson, James R; McCue, Hannah V; West, Anthony; Zulkower, Valentin; Tekotte, Hille; Cai, Yizhi; Swan, Daniel; Davey, Robert P; Hertz-Fowler, Christiane; Hall, Anthony; Caddick, Mark

    2017-12-15

    This paper presents Leaf LIMS, a flexible laboratory information management system (LIMS) designed to address the complexity of synthetic biology workflows. At the project's inception there was a lack of a LIMS designed specifically to address synthetic biology processes, with most systems focused on either next generation sequencing or biobanks and clinical sample handling. Leaf LIMS implements integrated project, item, and laboratory stock tracking, offering complete sample and construct genealogy, materials and lot tracking, and modular assay data capture. Hence, it enables highly configurable task-based workflows and supports data capture from project inception to completion. As such, in addition to it supporting synthetic biology it is ideal for many laboratory environments with multiple projects and users. The system is deployed as a web application through Docker and is provided under a permissive MIT license. It is freely available for download at https://leaflims.github.io .

  11. Competitividad de las agroindustrias del limón pertenecientes al clúster del limón mexicano en Colima, México

    OpenAIRE

    Magaña Sánchez, Pablo Adrián; Padilla Bernal, Luz Evelia; Vargas Hernández, José G.

    2010-01-01

    El presente trabajo se refiere al estudio del nivel de competitividad de las Agroindustrias del Limón pertenecientes al clúster del limón mexicano en Colima, México en base al modelo del IMD (International Institute for Management Development) como teoría de soporte. En este estudio se diseño y utilizó un instrumento de medición de acuerdo al modelo anteriormente mencionado adaptando las variables para el contexto de nuestro estudio. Es necesario mencionar que el modelo del IMD se utilizó par...

  12. LIM domains regulate protein kinase C activity: a novel molecular function.

    Science.gov (United States)

    Maturana, Andrés D; Nakagawa, Noritaka; Yoshimoto, Nobuo; Tatematsu, Kenji; Hoshijima, Masahiko; Tanizawa, Katsuyuki; Kuroda, Shun'ichi

    2011-05-01

    Enigma homolog protein 1 (ENH1) acts as a scaffold that selectively associates protein kinases and transcription factors with cytoskeletal elements. ENH1 comprises an N-terminal PDZ domain and three C-terminal LIM domains. Through the LIM domains ENH1 interacts with the N-terminal region of protein kinase C βI (PKCβI). Here, we show that when ENH1 is co-expressed, PKCβI is translocated from the cytoplasm to the plasma membrane in the absence of any other stimulation. Moreover expression of ENH1 markedly increases PKCβI activity in the absence of PKC activators. A similar activation of PKCβI was observed with co-expression of Cypher1 or Enigma, but not other LIM proteins. The region including the three LIM domains of ENH1 (residues 415-591) appears to be sufficient for this PKCβI activation. Finally, interaction with ENH1 also increases the activity of PKCα and PKCγ, whereas it reduces PKCζ activity. These findings provide strong evidence that ENH1 activates conventional PKCs by directly binding through its LIM domains. Thus, LIM domains have a novel molecular function: the regulation of PKC activities in a PKC isoform-specific manner. Copyright © 2011 Elsevier Inc. All rights reserved.

  13. The diversification of the LIM superclass at the base of the metazoa increased subcellular complexity and promoted multicellular specialization.

    Directory of Open Access Journals (Sweden)

    Bernard J Koch

    Full Text Available Throughout evolution, the LIM domain has been deployed in many different domain configurations, which has led to the formation of a large and distinct group of proteins. LIM proteins are involved in relaying stimuli received at the cell surface to the nucleus in order to regulate cell structure, motility, and division. Despite their fundamental roles in cellular processes and human disease, little is known about the evolution of the LIM superclass.We have identified and characterized all known LIM domain-containing proteins in six metazoans and three non-metazoans. In addition, we performed a phylogenetic analysis on all LIM domains and, in the process, have identified a number of novel non-LIM domains and motifs in each of these proteins. Based on these results, we have formalized a classification system for LIM proteins, provided reasonable timing for class and family origin events; and identified lineage-specific loss events. Our analysis is the first detailed description of the full set of LIM proteins from the non-bilaterian species examined in this study.Six of the 14 LIM classes originated in the stem lineage of the Metazoa. The expansion of the LIM superclass at the base of the Metazoa undoubtedly contributed to the increase in subcellular complexity required for the transition from a unicellular to multicellular lifestyle and, as such, was a critically important event in the history of animal multicellularity.

  14. An amphioxus LIM-homeobox gene, AmphiLim1/5, expressed early in the invaginating organizer region and later in differentiating cells of the kidney and central nervous system

    Science.gov (United States)

    Langeland, James A.; Holland, Linda Z.; Chastain, Roger A.; Holland, Nicholas D.

    2006-01-01

    A LIM-homeobox gene, AmphiLim1/5, from the Florida amphioxus (Branchiostoma floridae) encodes a protein that phylogenetic analysis positions at the base of a clade comprising vertebrate Lim1 and Lim5. Amphioxus AmphiLim1/5 is expressed in domains that are a composite of those of vertebrate Lim1 and Lim5, which evidently underwent subfunctionalization after duplication of an ancestral protochordate Lim1/5. During amphioxus development, transcription is first detected in the ectoderm of the blastula. Then, in the gastrula, a second expression domain appears in the mesendoderm just within the dorsal lip of the blastopore, a region known to have organizer properties in amphioxus. This mesendodermal expression corresponds to Lim1 expression in the Spemann organizer of vertebrates. At least one of the functions of vertebrate Lim1 in the organizer is to control the transcription of genes involved in cell and tissue movements during gastrulation, and a comparable early function seems likely for AmphiLim1/5 during gastrular invagination of amphioxus. Later embryos and larvae of amphioxus express AmphiLim1/5 in clusters of cells, probably motoneurons, in the anterior part of the central nervous system, in the hindgut, in Hatschek's right diverticulum (a rudiment of the rostral coelom), and in the wall of the first somite on the left side (a precursor of Hatschek's nephridium). In the early larva, expression continues in neural cells, in Hatschek's nephridium, in the wall of the rostral coelom, in the epidermis of the upper lip, and in mesoderm cells near the opening of the second gill slit. The developmental expression in Hatschek's nephridium is especially interesting because it helps support the homology between this amphioxus organ and the vertebrate pronephros. PMID:16763670

  15. An amphioxus LIM-homeobox gene, AmphiLim1/5, expressed early in the invaginating organizer region and later in differentiating cells of the kidney and central nervous system.

    Science.gov (United States)

    Langeland, James A; Holland, Linda Z; Chastain, Roger A; Holland, Nicholas D

    2006-01-01

    A LIM-homeobox gene, AmphiLim1/5, from the Florida amphioxus (Branchiostoma floridae) encodes a protein that phylogenetic analysis positions at the base of a clade comprising vertebrate Lim1 and Lim5. Amphioxus AmphiLim1/5 is expressed in domains that are a composite of those of vertebrate Lim1 and Lim5, which evidently underwent subfunctionalization after duplication of an ancestral protochordate Lim1/5. During amphioxus development, transcription is first detected in the ectoderm of the blastula. Then, in the gastrula, a second expression domain appears in the mesendoderm just within the dorsal lip of the blastopore, a region known to have organizer properties in amphioxus. This mesendodermal expression corresponds to Lim1 expression in the Spemann organizer of vertebrates. At least one of the functions of vertebrate Lim1 in the organizer is to control the transcription of genes involved in cell and tissue movements during gastrulation, and a comparable early function seems likely for AmphiLim1/5 during gastrular invagination of amphioxus. Later embryos and larvae of amphioxus express AmphiLim1/5 in clusters of cells, probably motoneurons, in the anterior part of the central nervous system, in the hindgut, in Hatschek's right diverticulum (a rudiment of the rostral coelom), and in the wall of the first somite on the left side (a precursor of Hatschek's nephridium). In the early larva, expression continues in neural cells, in Hatschek's nephridium, in the wall of the rostral coelom, in the epidermis of the upper lip, and in mesoderm cells near the opening of the second gill slit. The developmental expression in Hatschek's nephridium is especially interesting because it helps support the homology between this amphioxus organ and the vertebrate pronephros.

  16. Cyclic Testing of the 6-Strand Tang and Modified Lim-Tsai Flexor Tendon Repair Techniques.

    Science.gov (United States)

    Kang, Gavrielle Hui-Ying; Wong, Yoke-Rung; Lim, Rebecca Qian-Ru; Loke, Austin Mun-Kitt; Tay, Shian-Chao

    2017-09-26

    In this study, we compared the Tang repair technique with the 6-strand modified Lim-Tsai repair technique under cyclic testing conditions. Twenty fresh-frozen porcine flexor tendons were randomized into 2 groups for repair with either the modified Lim-Tsai or the Tang technique using Supramid 4-0 core sutures and Ethilon 6-0 epitendinous running suture. The repaired tendons were subjected to 2 stage cyclic loading. The survival rate and gap formation at the repair site were recorded. Tendons repaired by the Tang technique achieved an 80% survival rate. None of the modified Lim-Tsai repairs survived. The mean gap formed at the end of 1000 cycles was 1.09 mm in the Tang repairs compared with 4.15 mm in the modified Lim-Tsai repairs. The Tang repair is biomechanically stronger than the modified Lim-Tsai repair under cyclic loading. The Tang repair technique may exhibit a higher tolerance for active mobilization after surgery with less propensity for gap formation. Copyright © 2017 American Society for Surgery of the Hand. Published by Elsevier Inc. All rights reserved.

  17. Probabilistic Discounting of Hypothetical Monetary Gains: University Students Differ in How They Discount "Won" and "Owed" Money

    Science.gov (United States)

    Weatherly, Jeffrey N.; Derenne, Adam

    2013-01-01

    The present study tested whether participants would discount "won" money differently than they would "owed" money in a probability-discounting task. Participants discounted $1000 or $100,000 that they had won in a sweepstakes or that was owed to them using the multiple-choice (Experiment 1) or fill-in-the-blank (Experiment 2) method of collecting…

  18. On the quality of the Nimbus 7 LIMS Version 6 water vapor profiles and distributions

    Directory of Open Access Journals (Sweden)

    B. T. Marshall

    2009-12-01

    Full Text Available This report describes the quality of the Nimbus 7 Limb Infrared Monitor of the Stratosphere (LIMS water vapor (H2O profiles of 1978/79 that were processed with a Version 6 (V6 algorithm and archived in 2002. The V6 profiles incorporate a better knowledge of the instrument attitude for the LIMS measurements along its orbits, leading to improvements for its temperature profiles and for the registration of its water vapor radiances with pressure. As a result, the LIMS V6 zonal-mean distributions of H2O exhibit better hemispheric symmetry than was the case from the original Version 5 (V5 dataset that was archived in 1982. Estimates of the precision and accuracy of the V6 H2O profiles are developed and provided. Individual profiles have a precision of order 5% and an estimated accuracy of about 19% at 3 hPa, 14% at 10 hPa, and 26% at 50 hPa. Profile segments within about 2 km of the tropopause are often affected by emissions from clouds that appear in the finite field-of-view of the detector for the LIMS H2O channel. Zonally-averaged distributions of the LIMS V6 H2O are compared with those from the more recent Microwave Limb Sounder (MLS satellite experiment for November, February, and May of 2004/05. The patterns and values of their respective distributions are similar in many respects. Effects of a strengthened Brewer-Dobson circulation are indicated in the MLS distributions of the recent decade versus those of LIMS from 1978/79. A tropical tape recorder signal is present in the 7-month time series of LIMS V6 H2O with lowest values in February 1979, and the estimated, annually-averaged "entry-level" H2O is 3.5 to 3.8 ppmv. It is judged that this historic LIMS water vapor dataset is of good quality for studies of the near global-scale chemistry and transport for pressure levels from 3 hPa to about 70 to 100 hPa.

  19. Aspectos generales sobre la elaboración del licor de limón

    OpenAIRE

    Arlyn Reyes-Linares; Jorge Pino-Alea; Verónica Moreira-Ocanto

    2011-01-01

    Se presenta una revisión bibliográfica sobre el licor de limón (limoncello). Se abordan aspectos generales de esta temática, así como las materias primas que se emplean en su elaboración y los procesos de obtención. Se comentan los trabajos reportados relacionados con el licor de limón, los que muestran investigaciones sobre la composición, su caracterización para establecer la calidad del producto en el mercado y las posibles adulteraciones, así como el proceso de producción tradicional y un...

  20. Won-Buddhism and a Great Turning in Civilization: The Role of Religion

    Directory of Open Access Journals (Sweden)

    Paik Nak-chung

    2017-03-01

    Full Text Available Addressing the theme of a great turning in civilization, this essay focuses on the Korean religion Won-Buddhism with its founding motto, “With this Great Opening of matter, let there be a Great Opening of spirit.” Both its doctrine and practice arguably possess great potential. Unlike the traditional Buddhist view of enlightenment, Won-Buddhism’s “Great Opening of spirit” starts from a specific diagnosis of the current time as an age of “Great Opening of matter” and proposes a double project of at once adapting to and overcoming modernity. In this way, it carries on the tradition of Korea’s indigenous religious movements since the mid-nineteenth century, but by combining that strain with Buddhism as its core doctrine, it achieves a fuller global significance than its predecessors. The essay examines Roberto Unger’s The Religion of the Future for both parallels and divergences, sympathizing with Unger’s emphasis on a religious revolution, but finding his thought essentially confined within the limits of Western metaphysics. Martin Heidegger is brought in to elucidate this point, as is Karl Marx, for comparison and contrast with Won-Buddhism’s diagnosis of and response to modernity. In closing, the essay takes up two Won-Buddhist agendas that are also of global concern: gender equality and the “church and state” relation.

  1. The "Hollywoodization" of Education Reform in "Won't Back Down"

    Science.gov (United States)

    Goering, Christian Z.; Witte, Shelbie; Jennings Davis, Jennifer; Ward, Peggy; Flammang, Brandon; Gerhardson, Ashley

    2015-01-01

    What happens when forces attempting to privatize education create and produce a Hollywood film with an education reform plot line? This essay explores "Won't Back Down" through cultural studies and progressive education lenses in an effort to unveil misrepresentations of education and education reform. Drawing on scholarship in these…

  2. Knockdown of LIM15/DMC1 in the mushroom Coprinus cinereus by double-stranded RNA-mediated gene silencing.

    Science.gov (United States)

    Namekawa, Satoshi H; Iwabata, Kazuki; Sugawara, Hiroko; Hamada, Fumika N; Koshiyama, Akiyo; Chiku, Hiroyuki; Kamada, Takashi; Sakaguchi, Kengo

    2005-11-01

    The basidiomycete Coprinus cinereus has many advantages as a model organism for studying sexual development and meiosis, but it has been difficult to investigate using reverse-genetics methods, such as gene disruption by homologous recombination. Here, gene repression by dsRNA-mediated gene silencing was tried as an alternative method for reverse-genetics studies. It was shown that transformation of the LIM15/DMC1 dsRNA expression construct (LIM15dsRNA) resulted in genomic insertion of LIM15dsRNA and paucity of the LIM15/DMC1 transcript. First, LIM15dsRNA was transformed into the homothallic strain AmutBmut to generate a homozygote in which both nuclei had a copy of LIM15dsRNA. The LIM15/DMC1-repressed strain showed abnormal homologous chromosome synapsis during meiosis. Basidiospore production was reduced to 16 % by the induction of dsRNA. However, approximately 60 % of basidiospores were viable. Next, a heterozygote was generated in which one nucleus had a copy of LIM15dsRNA. The phenotype was similar to that of the homozygote. These results are not only the first demonstration of dsRNA-mediated gene silencing in a member of the homobasidiomycete fungi, to which 90 % of mushroom species belong, but also the first successful use of a reverse-genetics approach in C. cinereus research.

  3. LIM domains target actin regulators paxillin and zyxin to sites of stress fiber strain.

    Directory of Open Access Journals (Sweden)

    Mark A Smith

    Full Text Available Contractile actomyosin stress fibers are critical for maintaining the force balance between the interior of the cell and its environment. Consequently, the actin cytoskeleton undergoes dynamic mechanical loading. This results in spontaneous, stochastic, highly localized strain events, characterized by thinning and elongation within a discrete region of stress fiber. Previous work showed the LIM-domain adaptor protein, zyxin, is essential for repair and stabilization of these sites. Using live imaging, we show paxillin, another LIM-domain adaptor protein, is also recruited to stress fiber strain sites. Paxillin recruitment to stress fiber strain sites precedes zyxin recruitment. Zyxin and paxillin are each recruited independently of the other. In cells lacking paxillin, actin recovery is abrogated, resulting in slowed actin recovery and increased incidence of catastrophic stress fiber breaks. For both paxillin and zyxin, the LIM domains are necessary and sufficient for recruitment. This work provides further evidence of the critical role of LIM-domain proteins in responding to mechanical stress in the actin cytoskeleton.

  4. LIM Kinase Inhibitor Pyr1 Reduces the Growth and Metastatic Load of Breast Cancers

    NARCIS (Netherlands)

    Prunier, Chloé; Josserand, Véronique; Vollaire, Julien; Beerling, Evelyne; Petropoulos, Christos; Destaing, Olivier; Montemagno, Christopher; Hurbin, Amandine; Prudent, Renaud; de Koning, Leanne; Kapur, Reuben; Cohen, Pascale A; Albiges-Rizo, Corinne; Coll, Jean-Luc; van Rheenen, Jacco; Billaud, Marc; Lafanechère, Laurence

    2016-01-01

    LIM kinases (LIMK) are emerging targets for cancer therapy, and they function as network hubs to coordinate actin and microtubule dynamics. When LIMKs are inhibited, actin microfilaments are disorganized and microtubules are stabilized. Owing to their stabilizing effect on microtubules, LIMK

  5. LIM kinase inhibitor Pyr1 reduces the growth and metastatic load of breast cancers

    NARCIS (Netherlands)

    Prunier, Chloé; Josserand, Véronique; Vollaire, Julien; Beerling, Evelyne; Petropoulos, Christos; Destaing, Olivier; Montemagno, Christopher; Hurbin, Amandine; Prudent, Renaud; De Koning, Leanne; Kapur, Reuben; Cohen, Pascale A.; Albiges-Rizo, Corinne; Coll, Jean Luc; Van Rheenen, Jacco; Billaud, Marc; Lafanechère, Laurence

    2016-01-01

    LIM kinases (LIMK) are emerging targets for cancer therapy, and they function as network hubs to coordinate actin and microtubule dynamics. When LIMKs are inhibited, actin microfilaments are disorganized and microtubules are stabilized. Owing to their stabilizing effect on microtubules, LIMK

  6. A Couple of "Lim (h[right arrow]0)-Is-Missing" Problems

    Science.gov (United States)

    Lau, Ko Hin

    2007-01-01

    Since most students "hate" the concept of limit, in order to make them "happier," this article suggests a couple of naive "lim (h[right arrow]0)-is-missing" problems for them to try for fun. Indeed, differential functional equations that are related to difference quotients in calculus are studied in this paper. In particular, two interesting…

  7. MendeLIMS: a web-based laboratory information management system for clinical genome sequencing.

    Science.gov (United States)

    Grimes, Susan M; Ji, Hanlee P

    2014-08-27

    Large clinical genomics studies using next generation DNA sequencing require the ability to select and track samples from a large population of patients through many experimental steps. With the number of clinical genome sequencing studies increasing, it is critical to maintain adequate laboratory information management systems to manage the thousands of patient samples that are subject to this type of genetic analysis. To meet the needs of clinical population studies using genome sequencing, we developed a web-based laboratory information management system (LIMS) with a flexible configuration that is adaptable to continuously evolving experimental protocols of next generation DNA sequencing technologies. Our system is referred to as MendeLIMS, is easily implemented with open source tools and is also highly configurable and extensible. MendeLIMS has been invaluable in the management of our clinical genome sequencing studies. We maintain a publicly available demonstration version of the application for evaluation purposes at http://mendelims.stanford.edu. MendeLIMS is programmed in Ruby on Rails (RoR) and accesses data stored in SQL-compliant relational databases. Software is freely available for non-commercial use at http://dna-discovery.stanford.edu/software/mendelims/.

  8. Korean Literature in a Situation of Division : with an emphasis on Hwang Soon-Won's Novels

    OpenAIRE

    Pak, Jae-sup; 朴, 載變

    2004-01-01

    Korean war in 1950's has great influence on Korean literature. Hwang Soon-Won's novels portray the flow of history that contains Korean war and division (South and North Korea). Disintegration of personality, psychological frigidity, and pressure from poverty, pain of family separation caused by the war are well depicted in his works. But his literary accomplishment as the novelist, is showing how the traumatic experiences caused by the Korean War can be healed through humanity, with artistic...

  9. Saving Korean Won 1.07 billion by energy saving movement in 1999

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-08-01

    Hyosung is the biggest thread manufacturing company in Korea and the fourth in the World. It has integrated production system from nylon, polyester, and spandex thread to tirecord, textile fabrics, carpet and dyeing. Hyosung Kumi 1 factory, the biggest PET thread manufacturer in Korea producing 600 ton per day, is a highly energy consuming factory consuming 16.2 billion of energy and 8% of its sales. However, it saved Korean Won 1.07 billion in 1999 by implementing energy saving steadily.

  10. Organisation of the lamprey ( Lampetra fluviatilis) embryonic brain: Insights from LIM-homeodomain, Pax and hedgehog genes

    National Research Council Canada - National Science Library

    Osorio, Joana; Mazan, Sylvie; Rétaux, Sylvie

    2005-01-01

    To investigate the embryonic development of the central nervous system of the lamprey Lampetra fluviatilis, we have isolated and analysed the expression patterns of members of the LIM-homeodomain, Pax, Hedgehog and Nkx2.1 families...

  11. Insights into the molecular evolution of the PDZ/LIM family and identification of a novel conserved protein motif.

    Directory of Open Access Journals (Sweden)

    Aartjan J W Te Velthuis

    Full Text Available The PDZ and LIM domain-containing protein family is encoded by a diverse group of genes whose phylogeny has currently not been analyzed. In mammals, ten genes are found that encode both a PDZ- and one or several LIM-domains. These genes are: ALP, RIL, Elfin (CLP36, Mystique, Enigma (LMP-1, Enigma homologue (ENH, ZASP (Cypher, Oracle, LMO7 and the two LIM domain kinases (LIMK1 and LIMK2. As conventional alignment and phylogenetic procedures of full-length sequences fell short of elucidating the evolutionary history of these genes, we started to analyze the PDZ and LIM domain sequences themselves. Using information from most sequenced eukaryotic lineages, our phylogenetic analysis is based on full-length cDNA-, EST-derived- and genomic- PDZ and LIM domain sequences of over 25 species, ranging from yeast to humans. Plant and protozoan homologs were not found. Our phylogenetic analysis identifies a number of domain duplication and rearrangement events, and shows a single convergent event during evolution of the PDZ/LIM family. Further, we describe the separation of the ALP and Enigma subfamilies in lower vertebrates and identify a novel consensus motif, which we call 'ALP-like motif' (AM. This motif is highly-conserved between ALP subfamily proteins of diverse organisms. We used here a combinatorial approach to define the relation of the PDZ and LIM domain encoding genes and to reconstruct their phylogeny. This analysis allowed us to classify the PDZ/LIM family and to suggest a meaningful model for the molecular evolution of the diverse gene architectures found in this multi-domain family.

  12. ms_lims, a simple yet powerful open source laboratory information management system for MS-driven proteomics.

    Science.gov (United States)

    Helsens, Kenny; Colaert, Niklaas; Barsnes, Harald; Muth, Thilo; Flikka, Kristian; Staes, An; Timmerman, Evy; Wortelkamp, Steffi; Sickmann, Albert; Vandekerckhove, Joël; Gevaert, Kris; Martens, Lennart

    2010-03-01

    MS-based proteomics produces large amounts of mass spectra that require processing, identification and possibly quantification before interpretation can be undertaken. High-throughput studies require automation of these various steps, and management of the data in association with the results obtained. We here present ms_lims (http://genesis.UGent.be/ms_lims), a freely available, open-source system based on a central database to automate data management and processing in MS-driven proteomics analyses.

  13. MASTR-MS: a web-based collaborative laboratory information management system (LIMS) for metabolomics.

    Science.gov (United States)

    Hunter, Adam; Dayalan, Saravanan; De Souza, David; Power, Brad; Lorrimar, Rodney; Szabo, Tamas; Nguyen, Thu; O'Callaghan, Sean; Hack, Jeremy; Pyke, James; Nahid, Amsha; Barrero, Roberto; Roessner, Ute; Likic, Vladimir; Tull, Dedreia; Bacic, Antony; McConville, Malcolm; Bellgard, Matthew

    2017-01-01

    An increasing number of research laboratories and core analytical facilities around the world are developing high throughput metabolomic analytical and data processing pipelines that are capable of handling hundreds to thousands of individual samples per year, often over multiple projects, collaborations and sample types. At present, there are no Laboratory Information Management Systems (LIMS) that are specifically tailored for metabolomics laboratories that are capable of tracking samples and associated metadata from the beginning to the end of an experiment, including data processing and archiving, and which are also suitable for use in large institutional core facilities or multi-laboratory consortia as well as single laboratory environments. Here we present MASTR-MS, a downloadable and installable LIMS solution that can be deployed either within a single laboratory or used to link workflows across a multisite network. It comprises a Node Management System that can be used to link and manage projects across one or multiple collaborating laboratories; a User Management System which defines different user groups and privileges of users; a Quote Management System where client quotes are managed; a Project Management System in which metadata is stored and all aspects of project management, including experimental setup, sample tracking and instrument analysis, are defined, and a Data Management System that allows the automatic capture and storage of raw and processed data from the analytical instruments to the LIMS. MASTR-MS is a comprehensive LIMS solution specifically designed for metabolomics. It captures the entire lifecycle of a sample starting from project and experiment design to sample analysis, data capture and storage. It acts as an electronic notebook, facilitating project management within a single laboratory or a multi-node collaborative environment. This software is being developed in close consultation with members of the metabolomics research

  14. Oracle, a novel PDZ-LIM domain protein expressed in heart and skeletal muscle.

    Science.gov (United States)

    Passier, R; Richardson, J A; Olson, E N

    2000-04-01

    In order to identify novel genes enriched in adult heart, we performed a subtractive hybridization for genes expressed in mouse heart but not in skeletal muscle. We identified two alternative splicing variants of a novel PDZ-LIM domain protein, which we named Oracle. Both variants contain a PDZ domain at the amino-terminus and three LIM domains at the carboxy-terminus. Highest homology of Oracle was found with the human and rat enigma proteins in the PDZ domain (62 and 61%, respectively) and in the LIM domains (60 and 69%, respectively). By Northern hybridization analysis, we showed that expression is highest in adult mouse heart, low in skeletal muscle and undetectable in other adult mouse tissues. In situ hybridization in mouse embryos confirmed and extended these data by showing high expression of Oracle mRNA in atrial and ventricular myocardial cells from E8.5. From E9.5 low expression of Oracle mRNA was detectable in myotomes. These data suggest a role for Oracle in the early development and function of heart and skeletal muscle.

  15. Mutations in an atypical TIR-NB-LRR-LIM resistance protein confers autoimmunity

    Directory of Open Access Journals (Sweden)

    Dongling eBi

    2011-10-01

    Full Text Available In order to defend against infection, plants employ a complex immune system that relies partly on resistance (R proteins which initiate intricate signalling cascades upon pathogen detection. The resistance signalling network in plants is only partially characterized. A genetic screen conducted to identify novel defense regulators involved in this network resulted in the isolation of the snc6-1D mutant. Positional cloning revealed that this mutant contained a molecular lesion in the CHILLING SENSITIVE 3 (CHS3 gene, thus the allele was renamed chs3-2D. CHS3 encodes a TIR-NB-LRR R protein that contains a C-terminal zinc-binding LIM (Lin-11, Isl-1, Mec-3 domain. Although this protein has been previously implicated in cold stress and defense response, the role of the LIM domain in modulating protein activity is unclear. The chs3-2D allele contains a G to A point mutation causing a C1340 to Y1340 substitution close to the LIM domain. It encodes a dominant, gain-of-function mutation. The chs3-2D mutant is stunted and displays curled leaf morphology. Additionally, it constitutively expresses PATHOGENESIS-RELATED (PR genes, accumulates salicylic acid, and shows enhanced resistance to the virulent oomycete isolate Hyaloperonospora arabidopsidis (H.a. Noco2. Subcellular localization assays using GFP fusion constructs indicate that both CHS3 and chs3-2D localize to the nucleus. A third mutant allele, chs3-3D, was identified in an unrelated genetic screen in our lab. This allele contains a C to T point mutation resulting in an M1017 to V1017 substitution in the LRR-LIM linker region. Additionally, a chs3-2D suppressor screen identified two revertant alleles containing secondary mutations that abolish the mutant morphology. Analysis of the locations of these molecular lesions provides support for the hypothesis that the LIM domain represses CHS3 R-like protein activity. This repression may occur through either autoinhibition or binding of a negative defense

  16. Role of the New South Wales Department of Primary Industries' Laboratory Information Management System (LIMS) in the 2007 equine influenza emergency animal disease response.

    Science.gov (United States)

    Croft, M G; Fraser, G C; Gaul, W N

    2011-07-01

    A Laboratory Information Management System (LIMS) was used to manage the laboratory data and support planning and field activities as part of the response to the equine influenza outbreak in Australia in 2007. The database structure of the LIMS and the system configurations that were made to best handle the laboratory implications of the disease response are discussed. The operational aspects of the LIMS and the related procedures used at the laboratory to process the increased sample throughput are reviewed, as is the interaction of the LIMS with other corporate systems used in the management of the response. Outcomes from this tailored configuration and operation of the LIMS resulted in effective provision and control of the laboratory and laboratory information aspects of the response. The extent and immediate availability of the information provided from the LIMS was critical to some of the activities of key operatives involved in controlling the response. © 2011 The Authors. Australian Veterinary Journal © 2011 Australian Veterinary Association.

  17. adLIMS: a customized open source software that allows bridging clinical and basic molecular research studies.

    Science.gov (United States)

    Calabria, Andrea; Spinozzi, Giulio; Benedicenti, Fabrizio; Tenderini, Erika; Montini, Eugenio

    2015-01-01

    Many biological laboratories that deal with genomic samples are facing the problem of sample tracking, both for pure laboratory management and for efficiency. Our laboratory exploits PCR techniques and Next Generation Sequencing (NGS) methods to perform high-throughput integration site monitoring in different clinical trials and scientific projects. Because of the huge amount of samples that we process every year, which result in hundreds of millions of sequencing reads, we need to standardize data management and tracking systems, building up a scalable and flexible structure with web-based interfaces, which are usually called Laboratory Information Management System (LIMS). We started collecting end-users' requirements, composed of desired functionalities of the system and Graphical User Interfaces (GUI), and then we evaluated available tools that could address our requirements, spanning from pure LIMS to Content Management Systems (CMS) up to enterprise information systems. Our analysis identified ADempiere ERP, an open source Enterprise Resource Planning written in Java J2EE, as the best software that also natively implements some highly desirable technological advances, such as the high usability and modularity that grants high use-case flexibility and software scalability for custom solutions. We extended and customized ADempiere ERP to fulfil LIMS requirements and we developed adLIMS. It has been validated by our end-users verifying functionalities and GUIs through test cases for PCRs samples and pre-sequencing data and it is currently in use in our laboratories. adLIMS implements authorization and authentication policies, allowing multiple users management and roles definition that enables specific permissions, operations and data views to each user. For example, adLIMS allows creating sample sheets from stored data using available exporting operations. This simplicity and process standardization may avoid manual errors and information backtracking, features

  18. DNA polymerase mu interacts with a meiosis-specific RecA homolog Lim15 during meiosis in Coprinus cinereus.

    Science.gov (United States)

    Yanai, Takuro; Sakamoto, Aiko; Iwabata, Kazuki; Koshiyama, Akiyo; Sugawara, Hiroko; Nara, Takayuki; Takakusagi, Yoichi; Sakaguchi, Kengo

    2009-12-04

    Meiosis is a fundamental process in eukaryotes. Homologous chromosomes are paired and recombined during meiotic prophase I, which results in variation among the gametes. However, the mechanism of recombination between the maternal and paternal chromosome is unknown. In this study, we report on the identification of interaction between Coprinus cinereus DNA polymerase mu (CcPol mu) and CcLim15/Dmc1, a meiosis-specific RecA-like protein, during meiosis. Interaction between these two proteins was confirmed using a GST-pull down assay. A two-hybrid assay revealed that the N-terminus of CcPol mu, which includes the BRCT domain, is responsible for binding the C-terminus of CcLim15. Furthermore, co-immunoprecipitation experiments indicate that these two proteins also interact in the crude extract of the meiotic cell. A significant proportion of CcPol mu and CcLim15 is shown to co-localize in nuclei from the leptotene/zygotene stage to the early pachytene stage during meiotic prophase I. Moreover, CcLim15 enhances polymerase activity of CcPol mu early in the reaction. These results suggest that CcPol mu might be recruited by CcLim15 and elongate the D-loop structure during homologous recombination in meiosis.

  19. ROCK1 and LIM kinase modulate retrovirus particle release and cell-cell transmission events.

    Science.gov (United States)

    Wen, Xiaoyun; Ding, Lingmei; Wang, Jaang-Jiun; Qi, Mingli; Hammonds, Jason; Chu, Hin; Chen, Xuemin; Hunter, Eric; Spearman, Paul

    2014-06-01

    The assembly and release of retroviruses from the host cells require dynamic interactions between viral structural proteins and a variety of cellular factors. It has been long speculated that the actin cytoskeleton is involved in retrovirus production, and actin and actin-related proteins are enriched in HIV-1 virions. However, the specific role of actin in retrovirus assembly and release remains unknown. Here we identified LIM kinase 1 (LIMK1) as a cellular factor regulating HIV-1 and Mason-Pfizer monkey virus (M-PMV) particle release. Depletion of LIMK1 reduced not only particle output but also virus cell-cell transmission and was rescued by LIMK1 replenishment. Depletion of the upstream LIMK1 regulator ROCK1 inhibited particle release, as did a competitive peptide inhibitor of LIMK1 activity that prevented cofilin phosphorylation. Disruption of either ROCK1 or LIMK1 led to enhanced particle accumulation on the plasma membrane as revealed by total internal reflection fluorescence microscopy (TIRFM). Electron microscopy demonstrated a block to particle release, with clusters of fully mature particles on the surface of the cells. Our studies support a model in which ROCK1- and LIMK1-regulated phosphorylation of cofilin and subsequent local disruption of dynamic actin turnover play a role in retrovirus release from host cells and in cell-cell transmission events. Viruses often interact with the cellular cytoskeletal machinery in order to deliver their components to the site of assembly and budding. This study indicates that a key regulator of actin dynamics at the plasma membrane, LIM kinase, is important for the release of viral particles for HIV as well as for particle release by a distantly related retrovirus, Mason-Pfizer monkey virus. Moreover, disruption of LIM kinase greatly diminished the spread of HIV from cell to cell. These findings suggest that LIM kinase and its dynamic modulation of the actin cytoskeleton in the cell may be an important host factor for

  20. Evento principal y réplicas importantes del Terremoto de Limón

    OpenAIRE

    Montero, Walter; Pardo, Mario; Ponce, Lautaro; Rojas, Wilfredo; Fernández, Mario

    2011-01-01

    Combinando datos sismológicos obtenidos con estaciones locales, regionales y telesísmicas se definen las réplicas principales (magnitud Mc≥ 4,4) y el área de ruptura del Terremoto de Limón del 22 de abril de 1991 (Mw= 7,7). Este se encuentra es de 85 x 45 km2 y coincide con el encontrado con estaciones locales para temblores de magnitud ≥4,4. Datos de primeros impulsos obtenidos de diferentes distancias epicentrales, permiten definir el mecanismo focal del evento principal, el cual correspond...

  1. Análise da cadeia produtiva do capim limão: estudo de caso

    OpenAIRE

    E. C. GOMES; R.R.B NEGRELLE

    2015-01-01

    RESUMO:Apresentam-se 26 propostas e recomendações aos agentes econômicos da cadeia produtiva do capim-limão, considerando resultados de diferentes estudos sobre o cultivo e a comercialização desta espécie no Estado do Paraná, Brasil. As propostas e recomendações estão categorizadas de acordo aos distintos problemas identificados, com ênfase no cultivo e processamento, posto que estas atividades foram evidenciadas como as mais problemáticas e limitadoras da oferta de produto adequado ao comérc...

  2. Concentración de extracto pectínico de limón aplicando ultrafiltración

    OpenAIRE

    Damián Stechina; Miguel Pauletti; Claudia Lesa; Rodolfo Hugo Maffioly; Nicolas Bogdanoff; Oscar Iribarren

    2012-01-01

    La producción anual de limón en Argentina es aproximadamente de 900milt. El 75 % de la misma se deriva aindustrialización, básicamente destinado a la obtención de jugo pasteurizado concentrado. Como el 40-45 %de la fruta cítrica está formada por cáscara y semilla tenemos como residuo del limón 360milt anuales. Lacáscara del limón contiene alrededor del 30% (B.S.) de sustancias pépticas que tienen relevante valorcomercial por sus propiedades gelificantes y espesantes en una amplia variedad de ...

  3. Structural Basis for Noncanonical Substrate Recognition of Cofilin/ADF Proteins by LIM Kinases.

    Science.gov (United States)

    Hamill, Stephanie; Lou, Hua Jane; Turk, Benjamin E; Boggon, Titus J

    2016-05-05

    Cofilin/actin-depolymerizing factor (ADF) proteins are critical nodes that relay signals from protein kinase cascades to the actin cytoskeleton, in particular through site-specific phosphorylation at residue Ser3. This is important for regulation of the roles of cofilin in severing and stabilizing actin filaments. Consequently, cofilin/ADF Ser3 phosphorylation is tightly controlled as an almost exclusive substrate for LIM kinases. Here we determine the LIMK1:cofilin-1 co-crystal structure. We find an interface that is distinct from canonical kinase-substrate interactions. We validate this previously unobserved mechanism for high-fidelity kinase-substrate recognition by in vitro kinase assays, examination of cofilin phosphorylation in mammalian cells, and functional analysis in S. cerevisiae. The interface is conserved across all LIM kinases. Remarkably, we also observe both pre- and postphosphotransfer states in the same crystal lattice. This study therefore provides a molecular understanding of how kinase-substrate recognition acts as a gatekeeper to regulate actin cytoskeletal dynamics. Copyright © 2016 Elsevier Inc. All rights reserved.

  4. Structural basis for non-canonical substrate recognition of cofilin/ADF proteins by LIM kinases

    Science.gov (United States)

    Hamill, Stephanie; Lou, Hua Jane; Turk, Benjamin E.; Boggon, Titus J.

    2016-01-01

    SUMMARY Cofilin/actin-depolymerizing factor (ADF) proteins are critical nodes that relay signals from protein kinase cascades to the actin cytoskeleton, in particular through site-specific phosphorylation at residue Ser3. This is important for regulation of the roles of cofilin in severing and stabilizing actin filaments. Consequently, cofilin/ADF Ser3 phosphorylation is tightly controlled as an almost exclusive substrate for LIM kinases. Here we determine the LIMK1:cofilin-1 co-crystal structure. We find an interface that is distinct from canonical kinase-substrate interactions. We validate this previously unobserved mechanism for high fidelity kinase-substrate recognition by in vitro kinase assays, examination of cofilin phosphorylation in mammalian cells, and functional analysis in S. cerevisiae. The interface is conserved across all LIM kinases. Remarkably, we also observe both pre- and post-phosphotransfer states in the same crystal lattice. This study therefore provides a molecular understanding of how kinase-substrate recognition acts as a gatekeeper to regulate actin cytoskeletal dynamics. PMID:27153537

  5. The Hawaiian Algal Database: a laboratory LIMS and online resource for biodiversity data

    Directory of Open Access Journals (Sweden)

    Sauvage Thomas

    2009-09-01

    Full Text Available Abstract Background Organization and presentation of biodiversity data is greatly facilitated by databases that are specially designed to allow easy data entry and organized data display. Such databases also have the capacity to serve as Laboratory Information Management Systems (LIMS. The Hawaiian Algal Database was designed to showcase specimens collected from the Hawaiian Archipelago, enabling users around the world to compare their specimens with our photographs and DNA sequence data, and to provide lab personnel with an organizational tool for storing various biodiversity data types. Description We describe the Hawaiian Algal Database, a comprehensive and searchable database containing photographs and micrographs, geo-referenced collecting information, taxonomic checklists and standardized DNA sequence data. All data for individual samples are linked through unique accession numbers. Users can search online for sample information by accession number, numerous levels of taxonomy, or collection site. At the present time the database contains data representing over 2,000 samples of marine, freshwater and terrestrial algae from the Hawaiian Archipelago. These samples are primarily red algae, although other taxa are being added. Conclusion The Hawaiian Algal Database is a digital repository for Hawaiian algal samples and acts as a LIMS for the laboratory. Users can make use of the online search tool to view and download specimen photographs and micrographs, DNA sequences and relevant habitat data, including georeferenced collecting locations. It is publicly available at http://algae.manoa.hawaii.edu.

  6. The Hawaiian Algal Database: a laboratory LIMS and online resource for biodiversity data.

    Science.gov (United States)

    Wang, Norman; Sherwood, Alison R; Kurihara, Akira; Conklin, Kimberly Y; Sauvage, Thomas; Presting, Gernot G

    2009-09-04

    Organization and presentation of biodiversity data is greatly facilitated by databases that are specially designed to allow easy data entry and organized data display. Such databases also have the capacity to serve as Laboratory Information Management Systems (LIMS). The Hawaiian Algal Database was designed to showcase specimens collected from the Hawaiian Archipelago, enabling users around the world to compare their specimens with our photographs and DNA sequence data, and to provide lab personnel with an organizational tool for storing various biodiversity data types. We describe the Hawaiian Algal Database, a comprehensive and searchable database containing photographs and micrographs, geo-referenced collecting information, taxonomic checklists and standardized DNA sequence data. All data for individual samples are linked through unique accession numbers. Users can search online for sample information by accession number, numerous levels of taxonomy, or collection site. At the present time the database contains data representing over 2,000 samples of marine, freshwater and terrestrial algae from the Hawaiian Archipelago. These samples are primarily red algae, although other taxa are being added. The Hawaiian Algal Database is a digital repository for Hawaiian algal samples and acts as a LIMS for the laboratory. Users can make use of the online search tool to view and download specimen photographs and micrographs, DNA sequences and relevant habitat data, including georeferenced collecting locations. It is publicly available at http://algae.manoa.hawaii.edu.

  7. BiOSS LIM C: thin-strut cobalt-chromium version of the dedicated bifurcation stent.

    Science.gov (United States)

    Gil, Robert J; Bil, Jacek; Kaczynski, Mateusz; Milewski, Krzysztof P

    2017-04-01

    Coronary bifurcation lesions pose therapeutic challenges during percutaneous coronary interventions. Dedicated bifurcation stents are one of the treatment options available. Areas covered: This paper will analyze the results of the BiOSS (Bifurcation Optimization Stent System) Clinical Program with a special focus on the cobalt-chromium BiOSS LIM C stent which has recently been introduced into the market (CE 2016). The stent is characterized by a strut thickness of 70 µm and sirolimus concentration of 1.4 µg/mm2. Expert commentary: The first BiOSS stent was a bare metal one, but shortly after a paclitaxel-eluting version was introduced - BiOSS Expert stent (CE 2010). After acceptable results of BiOSS Expert stent were obtained in registries as well as in the randomized clinical trial POLBOS I, a way for improvement was to change paclitaxel into the - olimus drug. Sirolimus has been chosen and the BiOSS LIM stent was developed (CE 2012). BiOSS LIM is the dedicated bifurcation stent with stainless steel platform that releases sirolimus (1.4 µg/mm2) from the surface of a biodegradable coating comprised of a copolymer of lactic and glycolic acids. Nevertheless, the idea to reduce late lumen loss and as a result TLR rate by using thinner struts appeared. Therefore, presently first-in-man registry with BiOSS LIM C is ongoing.

  8. Structural Basis for Partial Redundancy in a Class of Transcription Factors, the LIM Homeodomain Proteins, in Neural Cell Type Specification*

    Science.gov (United States)

    Gadd, Morgan S.; Bhati, Mugdha; Jeffries, Cy M.; Langley, David B.; Trewhella, Jill; Guss, J. Mitchell; Matthews, Jacqueline M.

    2011-01-01

    Combinations of LIM homeodomain proteins form a transcriptional “LIM code” to direct the specification of neural cell types. Two paralogous pairs of LIM homeodomain proteins, LIM homeobox protein 3/4 (Lhx3/Lhx4) and Islet-1/2 (Isl1/Isl2), are expressed in developing ventral motor neurons. Lhx3 and Isl1 interact within a well characterized transcriptional complex that triggers motor neuron development, but it was not known whether Lhx4 and Isl2 could participate in equivalent complexes. We have identified an Lhx3-binding domain (LBD) in Isl2 based on sequence homology with the Isl1LBD and show that both Isl2LBD and Isl1LBD can bind each of Lhx3 and Lhx4. X-ray crystal- and small-angle x-ray scattering-derived solution structures of an Lhx4·Isl2 complex exhibit many similarities with that of Lhx3·Isl1; however, structural differences supported by mutagenic studies reveal differences in the mechanisms of binding. Differences in binding have implications for the mode of exchange of protein partners in transcriptional complexes and indicate a divergence in functions of Lhx3/4 and Isl1/2. The formation of weaker Lhx·Isl complexes would likely be masked by the availability of the other Lhx·Isl complexes in postmitotic motor neurons. PMID:22025611

  9. LIM homeobox protein 5 (Lhx5 is essential for mamillary body development

    Directory of Open Access Journals (Sweden)

    Amaya eMiquelajauregui

    2015-10-01

    Full Text Available The mamillary body (MM is a group of hypothalamic nuclei related to memory and spatial navigation that interconnects hippocampal, thalamic, and tegmental regions. Here we demonstrate that Lhx5, a LIM-HD domain transcription factor expressed early in the developing posterior hypothalamus, is required for the generation of the MM and its derived tracts. The MM markers Foxb1, Sim2 and Lhx1 are absent in Lhx5 knock-out mice from early embryonic stages, suggesting abnormal specification of this region. This was supported by the absence of Nkx2.1 and expansion of Shh in the prospective mamillary area. Interestingly, we also found an ectopic domain expressing Lhx2 and Lhx9 along the anterio-posterior hypothalamic axis. Our results suggest that Lhx5 controls early aspects of hypothalamic development by regulating gene expression and cellular specification in the prospective MM.

  10. A Lagrangian analysis of a sudden stratospheric warming - Comparison of a model simulation and LIMS observations

    Science.gov (United States)

    Pierce, R. B.; Remsberg, Ellis E.; Fairlie, T. D.; Blackshear, W. T.; Grose, William L.; Turner, Richard E.

    1992-01-01

    Lagrangian area diagnostics and trajectory techniques are used to investigate the radiative and dynamical characteristics of a spontaneous sudden warming which occurred during a 2-yr Langley Research Center model simulation. The ability of the Langley Research Center GCM to simulate the major features of the stratospheric circulation during such highly disturbed periods is illustrated by comparison of the simulated warming to the observed circulation during the LIMS observation period. The apparent sink of vortex area associated with Rossby wave-breaking accounts for the majority of the reduction of the size of the vortex and also acts to offset the radiatively driven increase in the area occupied by the 'surf zone'. Trajectory analysis of selected material lines substantiates the conclusions from the area diagnostics.

  11. Implementation of Close Loop Speed Control with VVVF Control and Slip Regulation on LIM

    Directory of Open Access Journals (Sweden)

    K. Aditya

    2014-04-01

    Full Text Available Open loop VVVF control has the disadvantage of low output torque when working at low frequency and poor speed precision at different load conditions.Various performance-improving schemes have been proposed for the basic VVVF control by compensating slips occurring in the low frequency range and slips caused by changing loads. Numerous papers have been published on the close loop speed control of rotary induction motor. In this paper a close loop speed control with VVVF control and slip regulation has been implemented for LIM based conveyor belt test Rig which compensates the disadvantages of traditional Volts/Hz control. SIMULINK results are presented to validate the effectiveness of proposed scheme.

  12. Relationships between Arctic sea ice drift and strength modelled by NEMO-LIM3.6

    Science.gov (United States)

    Docquier, David; Massonnet, François; Barthélemy, Antoine; Tandon, Neil F.; Lecomte, Olivier; Fichefet, Thierry

    2017-12-01

    Sea ice cover and thickness have substantially decreased in the Arctic Ocean since the beginning of the satellite era. As a result, sea ice strength has been reduced, allowing more deformation and fracturing and leading to increased sea ice drift speed. We use the version 3.6 of the global ocean-sea ice NEMO-LIM model (Nucleus for European Modelling of the Ocean coupled to the Louvain-la-Neuve sea Ice Model), satellite, buoy and submarine observations, as well as reanalysis data over the period from 1979 to 2013 to study these relationships. Overall, the model agrees well with observations in terms of sea ice extent, concentration and thickness. The seasonal cycle of sea ice drift speed is reasonably well reproduced by the model. NEMO-LIM3.6 is able to capture the relationships between the seasonal cycles of sea ice drift speed, concentration and thickness, with higher drift speed for both lower concentration and lower thickness, in agreement with observations. Model experiments are carried out to test the sensitivity of Arctic sea ice drift speed, thickness and concentration to changes in sea ice strength parameter P*. These show that higher values of P* generally lead to lower sea ice deformation and lower sea ice thickness, and that no single value of P* is the best option for reproducing the observed drift speed and thickness. The methodology proposed in this analysis provides a benchmark for a further model intercomparison related to the relationships between sea ice drift speed and strength, which is especially relevant in the context of the upcoming Coupled Model Intercomparison Project 6 (CMIP6).

  13. A new logo for the CERN Staff Association - Numerous prizes to be won

    CERN Multimedia

    2012-01-01

    The Staff Association needs a new logo, as CERN's new graphic charter does not allow the inclusion of the CERN logo.   A competition open to all is being organised by the Staff Association from 3 December 2012 to 30 January 2013 inclusive to choose this new logo. Numerous prizes are to be won such as an Ezee Suisse electric bike, vouchers and presents offered by our commercial partners such as Go Sport, Aquaparc, BCGE, L'Occitane, Sephora and the La Comédie de Genève theatre. All submissions will be on display in the Main Building from 4 to 15 February 2013. Six finalists will be selected: three by the jury, and three by CERN members of the personnel. Members of the CERN Staff Association will make the final choice of the winner amongst these finalists by electronic voting. The competition's rules are available here. For more information, please contact Sonia Casenove, tel. +41 22 767...

  14. [Fournier's gangrene, a battle won. Traditional cures versus a polyhexanide solution].

    Science.gov (United States)

    Rodríguez Cancio, M Concepción; Verdú Moresco, Aránzazu; Lorente Fernández, Gemma

    2008-11-01

    This article won the top place in the Third Prontosan Scientific Prize in 2008. Fournier's Gangrene is a rare process having an unknown origin which affects soft tissue in the genital and perirectal area. The authors describe the case of a 61 year old patient suffering from this disease, the recommended treatment by the Nurses' Consulting Office for Bed Sores, or Decubitus Ulcers, and Chronic Skin Ulcerations, and the patient's evolution. The medical team carried out a complete evaluation of this patient and his/her injury and took a sample to make a surface culture from. After this initial evaluation, the medical team's first recommendation was to apply treatment consisting of using polyhexanide combined with a calcic alginate dressing to control oozing; the objective of this treatment is to clean and decontaminate the wound and to provide the optimum conditions for a correct cicatrisation process in the least time possible. After 58 days undergoing treatment, the affected area did not show any sign nor symptom of infection and was practically finished with the cicatrisation process. The use of polyhexanide, in this case, proved to be the ideal therapeutic option to clean, decontaminate and maintain the conditions optimum for a correct cicatrisation of this wound.

  15. El limón (Citrus limon Burman f.L) ingrediente natural en la elaboración de confituras de frutas de alta calidad

    OpenAIRE

    Sánchez-Campillo Sánchez, Pedro

    2012-01-01

    El objetivo concreto de la presente tesis doctoral es la aplicación de productos derivados del limón, aprovechando y transformando el subproducto que se genera en la industrialización del limón, en la elaboración de confituras de melocotón. Dadas las propiedades excepcionales y composición del limón, este fruto o parte de él, puede sustituir, total o parcialmente a aditivos químicos (pectinas, ácidos, antioxidantes…) en la elaboración de confituras de frutas, con los siguientes logros: se ...

  16. Petroleum and Oil Fuel Lines running from Apra Harbor through the Antonio B. Won Pat International Airport to the Tanguisson Power Plant.

    Data.gov (United States)

    U.S. Environmental Protection Agency — This is a line feature dataset showing the track of petroleum and oil fuel lines that transport hazardous fluids from Apra Harbor through the Antonio B. Won Pat...

  17. Synthesis of Won-WX2 (n=2.7, 2.9; X=S, Se) Heterostructures for Highly Efficient Green Quantum Dot Light-Emitting Diodes

    KAUST Repository

    Han, Shikui

    2017-07-04

    Preparation of two-dimensional (2D) heterostructures is important not only fundamentally, but also technologically for applications in electronics and optoelectronics. Herein, we report a facile colloidal method for the synthesis of WOn -WX2 (n=2.7, 2.9; X=S, Se) heterostructures by sulfurization or selenization of WOn nanomaterials. The WOn -WX2 heterostructures are composed of WO2.9 nanoparticles (NPs) or WO2.7 nanowires (NWs) grown together with single- or few-layer WX2 nanosheets (NSs). As a proof-of-concept application, the WOn -WX2 heterostructures are used as the anode interfacial buffer layer for green quantum dot light-emitting diodes (QLEDs). The QLED prepared with WO2.9 NP-WSe2 NS heterostructures achieves external quantum efficiency (EQE) of 8.53 %. To our knowledge, this is the highest efficiency in the reported green QLEDs using inorganic materials as the hole injection layer.

  18. Estudo prospectivo da cadeia produtiva do capim-limão: estado do Paraná

    Directory of Open Access Journals (Sweden)

    Eliane Carneiro Gomes

    2004-12-01

    Full Text Available A aplicação de prospectiva para cadeias produtivas engloba várias etapas como a segmentação de cada elo, a análise do ambiente institucional e organizacional que envolve a cadeia, a identificação das necessidades e aspirações de cada segmento da cadeia e dos fatores críticos para a melhoria do desempenho. Desta forma, considerando a importância econômica da produção, industrialização e comercialização do capim-limão, Cymbopogon citratus (D.C. Stapf, e visando uma ação integrada do setor agrícola envolvido, este trabalho propõe o estudo prospectivo da cadeia produtiva desta espécie no estado do Paraná, identificando também fatores e condicionantes de qualidade em cada segmento desta cadeia. Para isto, o presente estudo apresenta o panorama da produção agroindustrial e da comunidade produtora agrícola paranaense de capim-limão; identifica e caracteriza os outros segmentos que integram a respectiva cadeia produtiva no Paraná e, por fim, identifica e analisa os principais gargalos, elos faltantes e pontos de estrangulamento. Evidenciaram-se como principais componentes da cadeia produtiva: a unidade produtiva, a agroindústria, a indústria (alimentícia, farmacêutica e química e o mercado consumidor interno (atacadista e varejista e externo. Com esse estudo prospectivo, espera-se contribuir para a implementação de medidas político-organizacionais, entre os agentes econômicos dos setores público e privado, que fazem parte da cadeia produtiva do capim-limão, possibilitando-lhes desenvolver estratégias que aumentem a competitividade e conduzam à expansão do mercado.The application of a prospective study to productive chains incorporates several stages like the segmentation of each link, the analysis of institutional and organizational environments to include the chain, the identification of necessities and aspirations of each chain segment and the critical factors for the improvement of performance. Thus

  19. Numerical Simulations of the 1991 Limón Tsunami, Costa Rica Caribbean Coast

    Science.gov (United States)

    Chacón-Barrantes, Silvia; Zamora, Natalia

    2017-08-01

    The second largest recorded tsunami along the Caribbean margin of Central America occurred 25 years ago. On April 22nd, 1991, an earthquake with magnitude Mw 7.6 ruptured along the thrust faults that form the North Panamá Deformed Belt (NPDB). The earthquake triggered a tsunami that affected the Caribbean coast of Costa Rica and Panamá within few minutes, generating two casualties. These are the only deaths caused by a tsunami in Costa Rica. Coseismic uplift up to 1.6 m and runup values larger than 2 m were measured along some coastal sites. Here, we consider three solutions for the seismic source as initial conditions to model the tsunami, each considering a single rupture plane. We performed numerical modeling of the tsunami propagation and runup using NEOWAVE numerical model (Yamazaki et al. in Int J Numer Methods Fluids 67:2081-2107, 2010, doi: 10.1002/fld.2485 ) on a system of nested grids from the entire Caribbean Sea to Limón city. The modeled surface deformation and tsunami runup agreed with the measured data along most of the coastal sites with one preferred model that fits the field data. The model results are useful to determine how the 1991 tsunami could have affected regions where tsunami records were not preserved and to simulate the effects of the coastal surface deformations as buffer to tsunami. We also performed tsunami modeling to simulate the consequences if a similar event with larger magnitude Mw 7.9 occurs offshore the southern Costa Rican Caribbean coast. Such event would generate maximum wave heights of more than 5 m showing that Limón and northwestern Panamá coastal areas are exposed to moderate-to-large tsunamis. These simulations considering historical events and maximum credible scenarios can be useful for hazard assessment and also as part of studies leading to tsunami evacuation maps and mitigation plans, even when that is not the scope of this paper.

  20. Uma visão psicobiológica da personalidade limítrofe Una visión psicobiológica de la personalidad limítrofe A psychobiological view of the borderline personality construct

    Directory of Open Access Journals (Sweden)

    Alan B. Eppel

    2005-12-01

    Full Text Available OBJETIVO: Revisar e reformular o conceito de distúrbio de personalidade limítrofe à luz dos avanços da neurociência e do desenvolvimento da infância. MÉTODO: A A base de dados Medline foi pesquisada utilizando-se as seguintes palavras-chave: personalidade limítrofe, regulação das emoções, neurobiologia, abuso sexual na infância, estabilizadores de humor. RESULTADOS: Existem predisposições genéticas a traços específicos de personalidade que parecem ser centrais aos conceitos de distúrbio de personalidade limítrofe. Esses traços combinados com relações de apego problemáticas e com abuso sexual na infância dão origem a vários efeitos conhecidos como distúrbio de personalidade limítrofe. CONCLUSÕES: O distúrbio de personalidade limítrofe é um distúrbio de regulação das emoções causado por fatores genéticos e interpessoais. IMPLICAÇÕES CLINICAS: As medidas preventivas deveriam ser direcionadas ao ambiente da primeira infância e à qualidade e disponibilidade de figuras de apego. O enfoque do tratamento deveria ser direcionado principalmente para a regulação das emoções, através de medicamentos, psicoterapia e treinamento de habilidades. Pesquisa básica a respeito da relação entre neuropeptídeos e serotonina poderiam levar a novas abordagens de intervenções psicofarmacológicas. LIMITAÇÕES: A pesquisa na área neurocientífica baseia-se principalmente em experimentos com animais e não podem ser totalmente extrapoladas para humanos. Há muito poucos ensaios clínicos randomizados controlados de antidepressivos e estabilizadores de humor em distúrbio de personalidade limítrofe. Devido à vastidão da literatura clínica e neurocientífica, essa revisão teve um enfoque selecionado.OBJETIVO: Revisar y reformular el concepto de disturbio de personalidad limítrofe a la luz de los avances de la neurociencia y del desarrollo de la niñez. MÉTODO: Se investigó la base de datos Medline, utiliz

  1. Disc-shaped LIM for levitation and traction force control powered by the source using the component synchronous with the motor speed

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    Morizane Toshimitsu

    2015-12-01

    Full Text Available It has been proposed that a novel maglev transport system uses both of the attractive force and thrust force of the Linear Induction Motor (LIM. In our proposal, these two forces will be controlled by two different frequency components. One of the frequency components is synchronous with the motor speed (fm. Another frequency component is drive frequency (fd. Our proposed system enables the independent and simultaneous control of the attractive and thrust force of LIM. Each value of the attractive and the thrust force generated by fm and fd must be identified in order to design that LIM control system. For these purpose, a disc-shaped LIM has been developed as an experimental equipment. The force profiles, especially around zero slip, have been analyzed under experimental conditions.

  2. LIMS/Nimbus-7 Level 2 Vertical Profiles of O3, NO2, H2O, HNO3, Geopotential Height, and Temperature V006

    Data.gov (United States)

    National Aeronautics and Space Administration — The Limb Infrared Monitor of the Stratosphere (LIMS) version 6 Level-2 data product consists of daily, geolocated, vertical profiles of temperature, geopotential...

  3. Why won't it Stick? Positive Psychology and Positive Education.

    Science.gov (United States)

    White, Mathew A

    Following the launch of the positive psychology movement teachers and educators emerged as early adopters of this fledgling science. This approach was called positive education. It describes scientifically validated programs from positive psychology, taught in schools, that have an impact on student well-being. The growing body of evidence about the reach of positive psychology has formed a convincing case to consider well-being an operational goal for educational systems. It is argued that this goal is pivotal and should be pursued in the same way in which we develop strategies to harness academic growth, school retention rates, and student engagement. National education policies can have widespread influence at the grassroots level on school improvement, good quality of classroom teaching and learning, student performance, creating confident and creative individuals and active and informed citizens, but not necessarily on the preventative skills for lifelong well-being. In this article I take stock on the positive education movement. Three approaches to positive education are identified and eight hurdles to the field are noted as reasons why positive education won't stick in policy. Then, I reflect on two case studies: a Well-being Summit and Round Table held at Wellington College and No. 10 Downing Street and Dr. Martin Seligman's role as Adelaide's Thinker in Residence as examples of grass-roots initiatives in well-being. Finally, six strategies are suggested for researchers and practitioners to grow the field. Last, I argued that until research centers focus on the development of common definitions of the key terms underpinning positive psychology, positive education and well-being the impact of the movement will be limited to a handful of institutions as models of best practice.

  4. The Cytotoxic Effect of Essential Oil of Syrian Citrus limon Peel on Human Colorectal Carcinoma Cell Line (Lim1863

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    Mohammad Eyad Chatty

    2012-01-01

    Full Text Available Background: Essential oils are the volatile fraction of aromatic and medicinal plants created after extraction by steam or water distillation. Species of the genus Citrus(Rutaceae have been widely used in traditional medicine as volatile oils and are currently the subject of numerous research. Citrus essential oil consists of different terpens that have antitumor activities. This study determines the cytotoxic effect of the essential oils of Citrus limon L. peels on a colorectal cancer cell line (LIM1863.Methods: We harvested four samples from four locations in Syria. Essential oils were prepared by hydrodistillation and analyzed by Gas chromatography-mass spectrometry (GC-MS.Various concentrations ofessential oils (0.5-48 μg/ml were added to cultured cells and incubated for 72 h. Cell viability was evaluated byMTT-basedcytotoxicity assay.Results: We noted 18 components that represented 98.81% of the total oil content. The major components were: limonene (61.8%-73.8%, γ-terpinene (9.4%-10.4%, β-pinene (3.7%-6.9%, O-cymene(1%-2.4%,and citral (0.8%-5.4%.The obtained IC50 value range of Citrus limon essential oils was 5.75-7.92 μg/ml against LIM1863.Conclusion: This study revealed that Syrian Citrus limon essential oil has a cytotoxic effect on the human colorectalcarcinoma cell line LIM1863 when studied in vitro.

  5. LIM-Homeodomain Transcription Factor Isl-1 Mediates Kisspeptin's Effect on Insulin Secretion in Mice

    Science.gov (United States)

    Chen, Juan; Fu, Rui; Cui, Yan; Pan, Jirong; Li, Yushan; Zhang, Xiaoxin; Evans, Sylvia M.; Cui, Sheng

    2014-01-01

    Kisspeptin and the G protein-coupled receptor 54 (GPR54) are highly abundant in the pancreas. In addition, circulating kisspeptin directly influences insulin secretion through GPR54. However, the mechanisms by which kisspeptin affects insulin release are unclear. The LIM-homeodomain transcription factor, Isl-1, is expressed in all pancreatic islet cells and is involved in regulating both islet development and insulin secretion. We therefore investigated potential interactions between kisspeptin and Isl-1. Our results demonstrate that Isl-1 and GPR54 are coexpressed in mouse pancreatic islet β-cells and NIT cells. Both in vitro and in vivo results demonstrate that kisspeptin-54 (KISS-54) inhibits Isl-1 expression and insulin secretion and both the in vivo and in vitro effects of KISS-54 on insulin gene expression and secretion are abolished when an Isl-1-inducible knockout model is used. Moreover, our results demonstrate that the direct action of KISS-54 on insulin secretion is mediated by Isl-1. Our results further show that KISS-54 influences Isl-1 expression and insulin secretion through the protein kinase C-ERK1/2 pathway. Conversely, insulin has a feedback loop via the Janus kinase-phosphatidylinositol 3-kinase pathway regulating kisspeptin expression and secretion. These findings are important in understanding mechanisms of insulin secretion and metabolism in diabetes. PMID:24956377

  6. K.S. Maniam, Jhumpa Lahiri, Shirley Lim: A Reflection of Culture and Identity

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    Hardev Kaur Jujar Singh

    2012-07-01

    Full Text Available “I do not want my house to be walled in on all sides and my windows to be stuffed. I want the culture of all lands to be blown about my house as freely as possible. But I refuse to be blown off my feet by any”—Mahatma Gandhi. With these sayings by Gandhiji, one will be able to understand why, even in a borderless world where the diffusion of races and culture happens all the time, and many would simply accept without restraint, the cultures and identity of their adopted land, there remain some writers who, despite being part of a new land, are still deeply influenced by their motherland and various aspects of life that are distinctive and peculiar to their motherland. The writers concerned in this paper are K.S Maniam, Shirley Lim and Jhumpa Lahiri. All these writers have nationalities not of their motherland, but somehow, their writings are usually immersed with the thoughts and culture of their motherland. In this study, we will examine the strong influences imbedded in these writers of the culture of their motherland despite being in their new land. We will also portray how some of the characters assimilate in their new land, whereas some still have a sense of belonging towards their motherland.

  7. LIM kinase regulation of cytoskeletal dynamics is required for salivary gland branching morphogenesis

    Science.gov (United States)

    Ray, Shayoni; Fanti, Joseph A.; Macedo, Diego P.; Larsen, Melinda

    2014-01-01

    Coordinated actin microfilament and microtubule dynamics is required for salivary gland development, although the mechanisms by which they contribute to branching morphogenesis are not defined. Because LIM kinase (LIMK) regulates both actin and microtubule organization, we investigated the role of LIMK signaling in mouse embryonic submandibular salivary glands using ex vivo organ cultures. Both LIMK 1 and 2 were necessary for branching morphogenesis and functioned to promote epithelial early- and late-stage cleft progression through regulation of both microfilaments and microtubules. LIMK-dependent regulation of these cytoskeletal systems was required to control focal adhesion protein–dependent fibronectin assembly and integrin β1 activation, involving the LIMK effectors cofilin and TPPP/p25, for assembly of the actin- and tubulin-based cytoskeletal systems, respectively. We demonstrate that LIMK regulates the early stages of cleft formation—cleft initiation, stabilization, and progression—via establishment of actin stability. Further, we reveal a novel role for the microtubule assembly factor p25 in regulating stabilization and elongation of late-stage progressing clefts. This study demonstrates the existence of multiple actin- and microtubule-dependent stabilization steps that are controlled by LIMK and are required in cleft progression during branching morphogenesis. PMID:24966172

  8. LIM kinase activity is required for microtubule organising centre positioning in mouse oocyte meiosis.

    Science.gov (United States)

    Li, Xin; Zhu, Yubo; Cao, Yan; Wang, Qian; Du, Juan; Tian, Jianhui; Liang, Yuanjing; Ma, Wei

    2017-04-01

    LIM kinase 1 (LIMK1) activity is essential for cell migration and cell cycle progression. Little is known about LIMK1 expression and function in mammalian oocytes. In the present study we assessed LIMK1 protein expression, subcellular distribution and function during mouse oocyte meiosis. Western blot analysis revealed high and stable expression of LIMK1 from the germinal vesicle (GV) to MII stage. In contrast, activated LIMK1 (i.e. LIMK1 phosphorylated at threonine 508 (pLIMK1Thr508)) was only detected after GV breakdown, with levels increasing gradually to peak at MI and MII. Immunofluorescence showed pLIMK1Thr508 was colocalised with the microtubule organising centre (MTOC) components pericentrin and γ-tubulin at the spindle poles. A direct interaction between γ-tubulin and pLIMK1Thr508 was confirmed by co-immunoprecipitation. LIMK inhibition with 1μM BMS3 damaged MTOC protein localisation to spindle poles, undermined the formation and positioning of functional MTOC and thus disrupted spindle formation and chromosome alignment. These effects were phenocopied by microinjection of LIMK1 antibody into mouse oocytes. In summary, the data demonstrate that LIMK activity is essential for MTOC organisation and distribution and so bipolar spindle formation and maintenance in mouse oocytes.

  9. Hoy hace: 13 años del Terremoto de Limón

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    Vallejos Vásquez, Sheily

    2005-08-01

    Full Text Available Se presenta una compilación de información referente al terremoto de Limón, ocurrido el día 22 de abril de 1991. Presenta algunos de los principales datos técnicos y de afectación. También explica los efectos producidos a nivel geológico y las acciones prioritarias que se realizaron. Por último, se expone la importancia que tuvo el sismo para la Comisión Nacional de Prevención de Riesgos y Atención de Emergencias y para la ejecución de iniciativas en la organización del país en el tema de los desastres It presents a compilation of the information in regards to the Limon earthquake, April 22, 1991. It presents some of the main technical and affectation data. It also explains the geological effects and the main actions taken. Lastly, it exposes the importance that the earthquake had for the National Commission of Risk Prevention and Emergency Response and for the execution of initiatives in the country organization in the topic of disasters

  10. The LIM-only protein FHL2 attenuates lung inflammation during bleomycin-induced fibrosis.

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    Abdulaleem Alnajar

    Full Text Available Fibrogenesis is usually initiated when regenerative processes have failed and/or chronic inflammation occurs. It is characterised by the activation of tissue fibroblasts and dysregulated synthesis of extracellular matrix proteins. FHL2 (four-and-a-half LIM domain protein 2 is a scaffolding protein that interacts with numerous cellular proteins, regulating signalling cascades and gene transcription. It is involved in tissue remodelling and tumour progression. Recent data suggest that FHL2 might support fibrogenesis by maintaining the transcriptional expression of alpha smooth muscle actin and the excessive synthesis and assembly of matrix proteins in activated fibroblasts. Here, we present evidence that FHL2 does not promote bleomycin-induced lung fibrosis, but rather suppresses this process by attenuating lung inflammation. Loss of FHL2 results in increased expression of the pro-inflammatory matrix protein tenascin C and downregulation of the macrophage activating C-type lectin receptor DC-SIGN. Consequently, FHL2 knockout mice developed a severe and long-lasting lung pathology following bleomycin administration due to enhanced expression of tenascin C and impaired activation of inflammation-resolving macrophages.

  11. Screensaver: an open source lab information management system (LIMS) for high throughput screening facilities.

    Science.gov (United States)

    Tolopko, Andrew N; Sullivan, John P; Erickson, Sean D; Wrobel, David; Chiang, Su L; Rudnicki, Katrina; Rudnicki, Stewart; Nale, Jennifer; Selfors, Laura M; Greenhouse, Dara; Muhlich, Jeremy L; Shamu, Caroline E

    2010-05-18

    Shared-usage high throughput screening (HTS) facilities are becoming more common in academe as large-scale small molecule and genome-scale RNAi screening strategies are adopted for basic research purposes. These shared facilities require a unique informatics infrastructure that must not only provide access to and analysis of screening data, but must also manage the administrative and technical challenges associated with conducting numerous, interleaved screening efforts run by multiple independent research groups. We have developed Screensaver, a free, open source, web-based lab information management system (LIMS), to address the informatics needs of our small molecule and RNAi screening facility. Screensaver supports the storage and comparison of screening data sets, as well as the management of information about screens, screeners, libraries, and laboratory work requests. To our knowledge, Screensaver is one of the first applications to support the storage and analysis of data from both genome-scale RNAi screening projects and small molecule screening projects. The informatics and administrative needs of an HTS facility may be best managed by a single, integrated, web-accessible application such as Screensaver. Screensaver has proven useful in meeting the requirements of the ICCB-Longwood/NSRB Screening Facility at Harvard Medical School, and has provided similar benefits to other HTS facilities.

  12. Screensaver: an open source lab information management system (LIMS for high throughput screening facilities

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    Nale Jennifer

    2010-05-01

    Full Text Available Abstract Background Shared-usage high throughput screening (HTS facilities are becoming more common in academe as large-scale small molecule and genome-scale RNAi screening strategies are adopted for basic research purposes. These shared facilities require a unique informatics infrastructure that must not only provide access to and analysis of screening data, but must also manage the administrative and technical challenges associated with conducting numerous, interleaved screening efforts run by multiple independent research groups. Results We have developed Screensaver, a free, open source, web-based lab information management system (LIMS, to address the informatics needs of our small molecule and RNAi screening facility. Screensaver supports the storage and comparison of screening data sets, as well as the management of information about screens, screeners, libraries, and laboratory work requests. To our knowledge, Screensaver is one of the first applications to support the storage and analysis of data from both genome-scale RNAi screening projects and small molecule screening projects. Conclusions The informatics and administrative needs of an HTS facility may be best managed by a single, integrated, web-accessible application such as Screensaver. Screensaver has proven useful in meeting the requirements of the ICCB-Longwood/NSRB Screening Facility at Harvard Medical School, and has provided similar benefits to other HTS facilities.

  13. A manual for a Laboratory Information Management System (LIMS) for light stable isotopes

    Science.gov (United States)

    Coplen, Tyler B.

    1998-01-01

    The reliability and accuracy of isotopic data can be improved by utilizing database software to (i) store information about samples, (ii) store the results of mass spectrometric isotope-ratio analyses of samples, (iii) calculate analytical results using standardized algorithms stored in a database, (iv) normalize stable isotopic data to international scales using isotopic reference materials, and (v) generate multi-sheet paper templates for convenient sample loading of automated mass-spectrometer sample preparation manifolds. Such a database program is presented herein. Major benefits of this system include (i) an increase in laboratory efficiency, (ii) reduction in the use of paper, (iii) reduction in workload due to the elimination or reduction of retyping of data by laboratory personnel, and (iv) decreased errors in data reported to sample submitters. Such a database provides a complete record of when and how often laboratory reference materials have been analyzed and provides a record of what correction factors have been used through time. It provides an audit trail for stable isotope laboratories. Since the original publication of the manual for LIMS for Light Stable Isotopes, the isotopes 3 H, 3 He, and 14 C, and the chlorofluorocarbons (CFCs), CFC-11, CFC-12, and CFC-113, have been added to this program.

  14. The adherens junction-associated LIM domain protein Smallish regulates epithelial morphogenesis.

    Science.gov (United States)

    Beati, Hamze; Peek, Irina; Hordowska, Paulina; Honemann-Capito, Mona; Glashauser, Jade; Renschler, Fabian A; Kakanj, Parisa; Ramrath, Andreas; Leptin, Maria; Luschnig, Stefan; Wiesner, Silke; Wodarz, Andreas

    2018-01-22

    In epithelia, cells adhere to each other in a dynamic fashion, allowing the cells to change their shape and move along each other during morphogenesis. The regulation of adhesion occurs at the belt-shaped adherens junction, the zonula adherens (ZA). Formation of the ZA depends on components of the Par-atypical PKC (Par-aPKC) complex of polarity regulators. We have identified the Lin11, Isl-1, Mec-3 (LIM) protein Smallish (Smash), the orthologue of vertebrate LMO7, as a binding partner of Bazooka/Par-3 (Baz), a core component of the Par-aPKC complex. Smash also binds to Canoe/Afadin and the tyrosine kinase Src42A and localizes to the ZA in a planar polarized fashion. Animals lacking Smash show loss of planar cell polarity (PCP) in the embryonic epidermis and reduced cell bond tension, leading to severe defects during embryonic morphogenesis of epithelial tissues and organs. Overexpression of Smash causes apical constriction of epithelial cells. We propose that Smash is a key regulator of morphogenesis coordinating PCP and actomyosin contractility at the ZA. © 2018 Beati et al.

  15. Expression of the Lhx genes apterous and lim1 in an errant polychaete: implications for bilaterian appendage evolution, neural development, and muscle diversification

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    Winchell Christopher J

    2013-02-01

    Full Text Available Abstract Background Arthropod and vertebrate appendages appear to have evolved via parallel co-option of a plesiomorphic gene regulatory network. Our previous work implies that annelids evolved unrelated appendage-forming mechanisms; we therefore found no support for homology of parapodia and arthropodia at the level of the whole appendage. We expand on that study here by asking whether expression of the LIM homeobox (Lhx genes apterous and lim1 in the annelid Neanthes arenaceodentata supports homology of the dorsal branches as well as the proximodistal axes of parapodia and arthropodia. In addition, we explore whether the neural expression of apterous and lim1 in Neanthes supports the putative ancestral function of the Lhx gene family in regulating the differentiation and maintenance of neuronal subtypes. Results Both genes exhibit continuous expression in specific portions of the developing central nervous system, from hatching to at least the 13-chaetiger stage. For example, nerve cord expression occurs in segmentally iterated patterns consisting of diffuse sets of many lim1-positive cells and comparatively fewer, clustered pairs of apterous-positive cells. Additionally, continuous apterous expression is observed in presumed neurosecretory ganglia of the posterior brain, while lim1 is continuously expressed in stomatogastric ganglia of the anterior brain. apterous is also expressed in the jaw sacs, dorsal parapodial muscles, and a presumed pair of cephalic sensory organs, whereas lim1 is expressed in multiple pharyngeal ganglia, the segmental peripheral nervous system, neuropodial chaetal sac muscles, and parapodial ligules. Conclusions The early and persistent nervous system expression of apterous and lim1 in Neanthes juveniles supports conservation of Lhx function in bilaterian neural differentiation and maintenance. Our results also suggest that diversification of parapodial muscle precursors involves a complementary LIM code similar to

  16. Shallow electrical resistivity imaging of the Limón fault, Chagres River Watershed, Panama Canal

    Science.gov (United States)

    Mojica, Alexis; Pérez, Tatiana; Toral, Jaime; Miranda, Roberto; Franceschi, Pastora; Calderón, Carlos; Vergara, Fidedigna

    2017-03-01

    The aim of this study was the use of electrical resistivity imaging to investigate the geometry of the southwest portion of one of the most important geologic fault zones of the Panama Canal Watershed: the Limón fault. This fault is characterized by its juxtaposition of pre-Tertiary andesitic basalt (Playa Venado Formation) against late Oligocene Tertiary sediments (Caimito Formation). In this zone, four 2D electrical resistivity tomography profiles were conducted perpendicular to the fault trace: T-1, T-2, T-3 and T-4. The T-1, T-3, and T-4 profiles were long profiles (235 m for the first two and 215 m for the last one), with a goal of determining the depth of the geologic boundary between the sedimentary and andesitic deposits. The T-2 profile was a short profile (23.5 m), with the objective of calibrating the results with data provided by the paleoseismic trenching previously developed in the area of interest. For these tests, two electrode arrays of types Wenner-Schlumberger and Dipole-Dipole, were used. For the inversion routine, two regularized least-squares methods were used: the smoothness-constrained method and robust inversion. The long electrical resistivity tomography profiles were able to identify a set of electrical anomalies associated with the andesitic basalt and the Tertiary sediments and with that, the contact geometry between these formations. In these profiles, fault angle measurements ranged from 60° to 80° with respect to the ground surface. In the T-2 profile, the electrical anomalies showed a good association with the results of the paleoseismic study. This allowed identification of the colluvium and alluvium covering the gravel and sand debris that mark the gradual transition to the soils of the Caimito Formation. Finally, a set of 2D synthetic models was developed for each of the T-1, T-3, and T-4 profiles with the objective of optimizing interpretation of the field results.

  17. Decomposition into Tradables and Nontradables and the Purchasing Power Parity (PPP Hypothesis of the Real Won-dollar Exchange Rate

    Directory of Open Access Journals (Sweden)

    Deockhyun Ryu

    2011-09-01

    Full Text Available The purpose of this paper is to test the purchasing power parity (PPP hypothesis using the won-dollar real exchange rate and analyze the effect of the decomposition into tradables and non-tradables on the change of the won-dollar real exchange rate. This paper decomposes the CPI-based real exchange rate into two parts according to Engel (1999; one is the relative price of traded goods between the countries, the other is a component that is a weighted difference of the relative price of nontraded-to traded-goods prices in each country. We construct this by comparing the component subsection weights in CPI. The empirical analysis of this paper consists of two parts as follows. First, we conducted a traditional time series analyses of the real exchange rate, tradable and non-tradable parts respectively, thereby testing the PPP hypothesis and other important hypotheses. Secondly, this paper conducted a Mean Squared Error (MSE analysis to evaluate the relative contribution of tradable and non-tradable parts to the change of real exchange rate. From the time series analysis, it is not guaranteed that the PPP hyThe purpose of this paper is to test the purchasing power parity (PPP hypothesis using the won-dollar real exchange rate and analyze the effect of the decomposition into tradables and non-tradables on the change of the won-dollar real exchange rate. This paper decomposes the CPI-based real exchange rate into two parts according to Engel (1999; one is the relative price of traded goods between the countries, the other is a component that is a weighted difference of the relative price of nontraded-to traded-goods prices in each country. We construct this by comparing the component subsection weights in CPI. The empirical analysis of this paper consists of two parts as follows. First, we conducted a traditional time series analyses of the real exchange rate, tradable and non-tradable parts respectively, thereby testing the PPP hypothesis and other

  18. Efeito do óleo de capim limão (Cymbopogon flexuosus Stapf no controle do carrapato dos bovinos

    Directory of Open Access Journals (Sweden)

    C.A. Agnolin

    2014-03-01

    Full Text Available Esta pesquisa foi conduzida com o objetivo de avaliar o efeito in vitro e in vivo do óleo essencial de capim limão (Cymbopogon flexuosus Stapf sobre o carrapato dos bovinos [Rhipicephalus (Boophilus microplus]. Na experimentação in vitro foi utilizado o grupo controle negativo e oito concentrações do óleo de capim-limão (0,5; 1; 2; 5; 10; 20; 50; 100%, em fêmeas ingurgitadas do carrapato. A eficácia de controle foi de 0; 20; 39; 99,5; 100; 100; 100; 100 e 100%, respectivamente. Para a experimentação in vivo foram constituídos três grupos (controle negativo, óleo de capim limão a 2,0% - nível estimado mediante análise de regressão, correspondendo a 95% de eficácia de controle do carrapato da pesquisa in vitro e amitraz a 0,025%, com dezoito vacas da raça Holandesa. Antes (média dos dias -3, -2, -1 e após a aplicação do produto (1, 2, 3, 5, 7, 10, 14 e 21 dias, foram contadas fêmeas ingurgitadas do carrapato. A eficácia de controle foi de 0; 54 e 74,5%, respectivamente, 21dias após o tratamento. Após a aplicação dos tratamentos (controle negativo x tratamento fitoterápico, foram avaliadas as variáveis fisiológicas: frequência cardíaca, respiratória, temperatura do globo ocular e temperatura da pele; os resultados foram similares entre os tratamentos.

  19. LimTox: a web tool for applied text mining of adverse event and toxicity associations of compounds, drugs and genes.

    Science.gov (United States)

    Cañada, Andres; Capella-Gutierrez, Salvador; Rabal, Obdulia; Oyarzabal, Julen; Valencia, Alfonso; Krallinger, Martin

    2017-07-03

    A considerable effort has been devoted to retrieve systematically information for genes and proteins as well as relationships between them. Despite the importance of chemical compounds and drugs as a central bio-entity in pharmacological and biological research, only a limited number of freely available chemical text-mining/search engine technologies are currently accessible. Here we present LimTox (Literature Mining for Toxicology), a web-based online biomedical search tool with special focus on adverse hepatobiliary reactions. It integrates a range of text mining, named entity recognition and information extraction components. LimTox relies on machine-learning, rule-based, pattern-based and term lookup strategies. This system processes scientific abstracts, a set of full text articles and medical agency assessment reports. Although the main focus of LimTox is on adverse liver events, it enables also basic searches for other organ level toxicity associations (nephrotoxicity, cardiotoxicity, thyrotoxicity and phospholipidosis). This tool supports specialized search queries for: chemical compounds/drugs, genes (with additional emphasis on key enzymes in drug metabolism, namely P450 cytochromes-CYPs) and biochemical liver markers. The LimTox website is free and open to all users and there is no login requirement. LimTox can be accessed at: http://limtox.bioinfo.cnio.es. © The Author(s) 2017. Published by Oxford University Press on behalf of Nucleic Acids Research.

  20. Acción Bactericida del Jugo de Limón Sobre el Staphylococcus Aureus Rosenbach

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    Obregón Botero. Rafael

    1946-04-01

    Full Text Available El objeto de este experimento fue el determinar la influencia que pudiera tener el jugo de limón común (citrus limonia Osbeck sobre el Staphylococcus; aureus Rosenbach. Esta bacteria se encuentra con frecuencia en la piel y el pelo del hombre y de los animales, también en el pus y con frecuencia asociados a muchas otras causantes de abcesos, forúnculos, nacidos, etc. Ocasionalmente pueden causar osteomielitis y endocarditis. En individuos tuberculosos las infecciones causadas por esta bacteria pueden ocasionar la muerte.

  1. Tectónica y estratigrafía de la Cuenca Limón Sur

    OpenAIRE

    Fernández, José Alberto; Bottazzi, Giovanni; Barboza, Guillermo; Astorga, Allan

    2011-01-01

    La Cuenca Limón Sur es una depresión sedimentaria elongada localizada en la región tras arco hacia la costa caribeña de Costa Rica. Esta cuenca ha sido sometida al efecto de varias fases tectónicas compresivas a través de su historia geológica. La primera fase compresiva está documentada por una serie de estructuras positivas con orientación Este Oeste, como resultado de esfuerzos dirigidos hacia el Norte que tuvieron durante el Eoceno Medio tardío. La segunda fase se cxpresa como una asociac...

  2. Concentración de extracto pectínico de limón aplicando ultrafiltración

    Directory of Open Access Journals (Sweden)

    Damián Stechina

    2012-01-01

    Full Text Available La producción anual de limón en Argentina es aproximadamente de 900milt. El 75 % de la misma se deriva aindustrialización, básicamente destinado a la obtención de jugo pasteurizado concentrado. Como el 40-45 %de la fruta cítrica está formada por cáscara y semilla tenemos como residuo del limón 360milt anuales. Lacáscara del limón contiene alrededor del 30% (B.S. de sustancias pépticas que tienen relevante valorcomercial por sus propiedades gelificantes y espesantes en una amplia variedad de productos alimenticios,farmacológicos y cosmetológicos. Los procesos de membranatienen múltiples aplicaciones en la elaboraciónde alimentos. En este trabajo se analiza la influencia de las variables operativas de ultrafiltración en el flujo depermeado instantáneo (FP y el requerimiento energético en la concentración de extracto pectínico obtenido decáscara de limón. Se trabajó con un módulo de laboratorio DDS, modelo LAB 20-772 provisto de membranasde material sintético cuyo poder de corte es 9 kDa, lo que da una resistencia intrínseca de membrana (Rm de3*1013m-1. Los resultados obtenidos ponen de manifiesto la caída de FPmotivado por la presencia de laresistencia debido a la polarización, la influencia de las variables operativas en el FPy brindan la informaciónnecesaria para estimar el requerimiento energético en funcióndel caudal de alimentación, a temperaturaconstante, el cual puede compararse con el incremento de concentración de pectina en la corriente del retenidorespecto a la concentración del extracto inicial.

  3. Lim homeobox genes in the Ctenophore Mnemiopsis leidyi: the evolution of neural cell type specification

    Directory of Open Access Journals (Sweden)

    Simmons David K

    2012-01-01

    Full Text Available Abstract Background Nervous systems are thought to be important to the evolutionary success and diversification of metazoans, yet little is known about the origin of simple nervous systems at the base of the animal tree. Recent data suggest that ctenophores, a group of macroscopic pelagic marine invertebrates, are the most ancient group of animals that possess a definitive nervous system consisting of a distributed nerve net and an apical statocyst. This study reports on details of the evolution of the neural cell type specifying transcription factor family of LIM homeobox containing genes (Lhx, which have highly conserved functions in neural specification in bilaterian animals. Results Using next generation sequencing, the first draft of the genome of the ctenophore Mnemiopsis leidyi has been generated. The Lhx genes in all animals are represented by seven subfamilies (Lhx1/5, Lhx3/4, Lmx, Islet, Lhx2/9, Lhx6/8, and LMO of which four were found to be represented in the ctenophore lineage (Lhx1/5, Lhx3/4, Lmx, and Islet. Interestingly, the ctenophore Lhx gene complement is more similar to the sponge complement (sponges do not possess neurons than to either the cnidarian-bilaterian or placozoan Lhx complements. Using whole mount in situ hybridization, the Lhx gene expression patterns were examined and found to be expressed around the blastopore and in cells that give rise to the apical organ and putative neural sensory cells. Conclusion This research gives us a first look at neural cell type specification in the ctenophore M. leidyi. Within M. leidyi, Lhx genes are expressed in overlapping domains within proposed neural cellular and sensory cell territories. These data suggest that Lhx genes likely played a conserved role in the patterning of sensory cells in the ancestor of sponges and ctenophores, and may provide a link to the expression of Lhx orthologs in sponge larval photoreceptive cells. Lhx genes were later co-opted into patterning more

  4. Voces pancaribeñas en América Central: Anacristina Rossi y Limón Reggae

    Directory of Open Access Journals (Sweden)

    Carol Pearson

    2013-08-01

    Full Text Available En Limón Reggae, la autora describe las experiencias de una protagonista que no tiene entrada en ningún grupo: nación, raza o grupo político. Son representaciones de las comunidades afrocaribeñas junto con la lucha revolucionaria en El Salvador y las experiencias de los niños de la calle. En After Exile, Amy Kaminsky plantea la presencia de imágenes corporales en la obra de muchos escritores latinoamericanos exiliados o expatriados. Rossi explora situaciones desesperadas centroamericanas y mundiales, junto a una lucha de resistencia. In Limón Reggae, the author describes the experiences of a protagonist who never finds acceptance or inclusion in any group, whether that of nation, ethnicity or politics. We find representations of Afro-Caribbean communities along with the revolutionary struggle in El Salvador and the experiences of present-day street children. In After Exile, Amy Kaminsky acknowledges the presence of images of the body in the work of many Latin American writers who have been exiled or have lived expatriate lives. Rossi explores desperate situations, both Central American and worldwide, together with a resistance struggle.

  5. The Province and Port of Limón: Metaphors for Afro-Costa Rican Black Identity

    Directory of Open Access Journals (Sweden)

    Carmen Hutchinson Miller Ph.D

    2013-06-01

    Full Text Available A significant number of Afro-Caribbean immigrant workers from the Anglo Spanish, and French Caribbean migrated to the Central American country called Costa Rica, to work on the construction of a railroad, 140 years ago (1872. Strained economic conditions in their homelands in the late 19th century was the push factor that forced them out of their homes in search for better opportunities that would improve their own and the lives of the families they left behind. Large numbers of these immigrants were forced to settle in the province and port of Limón. The unintentional settlement resulted in the biological reproduction of the present Afro-Costa Rican population, who are still not fully accepted within the society. This group of people maintains cultural aspects of the Caribbean immigrant culture, particularly that of Jamaica. This paper will demonstrate from the perspective of history some of the reasons why the province and port of Limón can be considered metaphors for Afro-Costa Rican Black Identity, using both primary sources and secondary information found in archival documents, newspaper clippings, interviews, and other publications.

  6. The Province and Port of Limón: Metaphors for Afro-Costa Rican Black Identity

    Directory of Open Access Journals (Sweden)

    Carmen Hutchinson Miller Ph.D

    2013-06-01

    Full Text Available  A significant number of Afro-Caribbean immigrant workers from the Anglo Spanish, and French Caribbean migrated to the Central American country called Costa Rica, to work on the construction of a railroad, 140 years ago (1872. Strained economic conditions in their homelands in the late 19th century was the push factor that forced them out of their homes in search for better opportunities that would improve their own and the lives of the families they left behind. Large numbers of these immigrants were forced to settle in the province and port of Limón. The unintentional settlement resulted in the biological reproduction of the present Afro-Costa Rican population, who are still not fully accepted within the society. This group of people maintains cultural aspects of the Caribbean immigrant culture, particularly that of Jamaica. This paper will demonstrate from the perspective of history some of the reasons why the province and port of Limón can be considered metaphors for Afro-Costa Rican Black Identity, using both primary sources and secondary information found in archival documents, newspaper clippings, interviews, and other publications. 

  7. Nuevo equipo de proceso de destilación fraccionada en continuo por arrastre con vapor de aceites esenciales del jugo de limón mexicano

    OpenAIRE

    Francisco J. Padilla M.; Orfil González R.; Rogelio Prado R.; Humberto Gutiérrez P.; Mirna Estarrón E.; Hugo A. Vega G.; José D. Padilla de la R.

    2007-01-01

    En este trabajo se presenta un nuevo equipo llamado Destilador-Fraccionador Horizontal, para realizar el procesos de destilación fraccionada en continuo por arrastre de vapor de aceites esenciales obtenidos a partir del jugo de limón mexicano (Citrus aurantifolia). La capacidad de fraccionación del nuevo equipo es analizada con soluciones modelo y soluciones reales de jugo de limón. Se emplean diseños experimentales y métodos estadísticos para investigar el desempeño del equipo y par...

  8. Controle de plantas invasoras em cultivo orgânico e convencional de capim-limão (Cymbopogon citratus (DC) Stapf.)

    OpenAIRE

    Lemos,G.C.S.; Santos, A D; S.P. Freitas; GRAVINA, G. de A.

    2013-01-01

    O cultivo orgânico é preconizado para o capim-limão (Cymbopogon citratus (DC) Stapf.) como planta medicinal promissora ao desenvolvimento de fármacos no Brasil. Objetivou-se avaliar técnicas de controle de plantas invasoras sobre componentes de produção de capim limão em cultivos orgânico e convencional. Dois experimentos foram instalados sob delineamento inteiramente casualizado, com quatro repetições, em esquema fatorial 2x2x3, considerando-se duas áreas (orgânico e convencional) e os trata...

  9. Cambios en los compuestos volátiles de un concentrado de sabor limón por la presencia de ácido cítrico

    OpenAIRE

    J. A. Pino; Sauri-Duch, E.; Cuevas-Glory, L.

    2008-01-01

    En el presente trabajo se estudiaron los cambios de los componentes volátiles de un concentrado de sabor limón para preparar bebidas de limón durante 6 meses de conservación a 40 ºC. Se identificaron 44 compuestos aislados mediante microextracción en fase sólida del espacio de cabeza en combinación con la cromatografía de gases- espectrometría de masas. El limoneno, γ-terpineno, acetato de citronelilo, acetato de nerilo y acetato de geranilo, disminuyeron su contenido ...

  10. Tratamiento biológico de residuos semisólidos y efluentes líquidos de la industria del procesado del limón

    OpenAIRE

    Machado López, Walter Daniel

    2017-01-01

    En la provincia de Tucumán (Argentina) se procesan alrededor de un millón de toneladas de limón, generando residuos y aguas residuales equivalentes a una población de 700.000 habitantes, siendo necesario el tratamiento de los mismos para reducir su impacto ambiental. Las aguas residuales presentan concentraciones elevadas de materia orgánica, bajos niveles de pH y elevado contenido en sólidos como consecuencia de la incorporación de restos de cáscara y pulpa de limón. Las tecnologías inicialm...

  11. A guide for the laboratory information management system (LIMS) for light stable isotopes--Versions 7 and 8

    Science.gov (United States)

    Coplen, Tyler B.

    2000-01-01

    The reliability and accuracy of isotopic data can be improved by utilizing database software to (i) store information about samples, (ii) store the results of mass spectrometric isotope-ratio analyses of samples, (iii) calculate analytical results using standardized algorithms stored in a database, (iv) normalize stable isotopic data to international scales using isotopic reference materials, and (v) generate multi-sheet paper templates for convenient sample loading of automated mass-spectrometer sample preparation manifolds. Such a database program, the Laboratory Information Management System (LIMS) for Light Stable Isotopes, is presented herein. Major benefits of this system include (i) a dramatic improvement in quality assurance, (ii) an increase in laboratory efficiency, (iii) a reduction in workload due to the elimination or reduction of retyping of data by laboratory personnel, and (iv) a decrease in errors in data reported to sample submitters. Such a database provides a complete record of when and how often laboratory reference materials have been analyzed and provides a record of what correction factors have been used through time. It provides an audit trail for laboratories. LIMS for Light Stable Isotopes is available for both Microsoft Office 97 Professional and Microsoft Office 2000 Professional as versions 7 and 8, respectively. Both source code (mdb file) and precompiled executable files (mde) are available. Numerous improvements have been made for continuous flow isotopic analysis in this version (specifically 7.13 for Microsoft Access 97 and 8.13 for Microsoft Access 2000). It is much easier to import isotopic results from Finnigan ISODAT worksheets, even worksheets on which corrections for amount of sample (linearity corrections) have been added. The capability to determine blank corrections using isotope mass balance from analyses of elemental analyzer samples has been added. It is now possible to calculate and apply drift corrections to isotopic

  12. [The early medical textbooks in Korea: medical textbooks published at Je Joong Won-Severance Hospital Medical School].

    Science.gov (United States)

    Park, H W

    1998-01-01

    Kwang Hye Won(Je Joong Won), the first western hospital in Korea, was founded in 1885. The first western Medical School in Korea was open in 1886 under the hospital management. Dr. O. R. Avison, who came to Korea in 1893, resumed the medical education there, which was interrupted for some time before his arrival in Korea. He inaugurated translating and publishing medical textbooks with the help of Kim Pil Soon who later became one of the first seven graduates in Severance Hospital Medical School. The first western medical textbook translated into Korean was Henry Gray's Anatomy. However, these twice-translated manuscripts were never to be published on account of being lost and burnt down. The existing early anatomy textbooks, the editions of 1906 and 1909, are not the translation of Gray's Anatomy, but that of Japanese anatomy textbook of Gonda. The remaining oldest medical textbook in Korean is Inorganic Materia Medica published in 1905. This book is unique among its kind that O. R. Avison is the only translator of the book and it contains the prefaces of O. R. Avison and Kim Pil Soon. The publication of medical textbook was animated by the participation of other medical students, such as Hong Suk Hoo and Hong Jong Eun. The list of medical textbooks published includes almost all the field of medicine. The medical textbooks in actual existence are as follows: Inorganic Materia Medica (1905), Inorganic Chemistry (1906), Anatomy I (1906), Physiology (1906), Diagnostics I (1906), Diagnostics II (1907), Obstetrics (1908), Organic Chemistry (1909), Anatomy (1909), and Surgery (1910).

  13. LIM-Only Protein 4 (LMO4 and LIM Domain Binding Protein 1 (LDB1 Promote Growth and Metastasis of Human Head and Neck Cancer (LMO4 and LDB1 in Head and Neck Cancer.

    Directory of Open Access Journals (Sweden)

    Elizabeth A Simonik

    Full Text Available Squamous cell carcinoma of the head and neck (HNSCC accounts for more than 300,000 deaths worldwide per year as a consequence of tumor cell invasion of adjacent structures or metastasis. LIM-only protein 4 (LMO4 and LIM-domain binding protein 1 (LDB1, two directly interacting transcriptional adaptors that have important roles in normal epithelial cell differentiation, have been associated with increased metastasis, decreased differentiation, and shortened survival in carcinoma of the breast. Here, we implicate two LDB1-binding proteins, single-stranded binding protein 2 (SSBP2 and 3 (SSBP3, in controlling LMO4 and LDB1 protein abundance in HNSCC and in regulating specific tumor cell functions in this disease. First, we found that the relative abundance of LMO4, LDB1, and the two SSBPs correlated very significantly in a panel of human HNSCC cell lines. Second, expression of these proteins in tumor primaries and lymph nodes involved by metastasis were concordant in 3 of 3 sets of tissue. Third, using a Matrigel invasion and organotypic reconstruct assay, CRISPR/Cas9-mediated deletion of LDB1 in the VU-SCC-1729 cell line, which is highly invasive of basement membrane and cellular monolayers, reduced tumor cell invasiveness and migration, as well as proliferation on tissue culture plastic. Finally, inactivation of the LDB1 gene in these cells decreased growth and vascularization of xenografted human tumor cells in vivo. These data show that LMO4, LDB1, and SSBP2 and/or SSBP3 regulate metastasis, proliferation, and angiogenesis in HNSCC and provide the first evidence that SSBPs control LMO4 and LDB1 protein abundance in a cancer context.

  14. Comparative study of sea ice dynamics simulations with a Maxwell elasto-brittle rheology and the elastic-viscous-plastic rheology in NEMO-LIM3

    Science.gov (United States)

    Raulier, Jonathan; Dansereau, Véronique; Fichefet, Thierry; Legat, Vincent; Weiss, Jérôme

    2017-04-01

    Sea ice is a highly dynamical environment characterized by a dense mesh of fractures or leads, constantly opening and closing over short time scales. This characteristic geomorphology is linked to the existence of linear kinematic features, which consist of quasi-linear patterns emerging from the observed strain rate field of sea ice. Standard rheologies used in most state-of-the-art sea ice models, like the well-known elastic-viscous-plastic rheology, are thought to misrepresent those linear kinematic features and the observed statistical distribution of deformation rates. Dedicated rheologies built to catch the processes known to be at the origin of the formation of leads are developed but still need evaluations on the global scale. One of them, based on a Maxwell elasto-brittle formulation, is being integrated in the NEMO-LIM3 global ocean-sea ice model (www.nemo-ocean.eu; www.elic.ucl.ac.be/lim). In the present study, we compare the results of the sea ice model LIM3 obtained with two different rheologies: the elastic-viscous-plastic rheology commonly used in LIM3 and a Maxwell elasto-brittle rheology. This comparison is focused on the statistical characteristics of the simulated deformation rate and on the ability of the model to reproduce the existence of leads within the ice pack. The impact of the lead representation on fluxes between ice, atmosphere and ocean is also assessed.

  15. Tratamento farmacológico do transtorno de personalidade limítrofe: revisão crítica da literatura e desenvolvimento de algoritmos

    National Research Council Canada - National Science Library

    Carvalho, André F; Stracke, Cristiane B; Souza, Fábio G. de Matos e

    2004-01-01

    INTRODUÇÃO: O transtorno de personalidade limítrofe (TPL) é uma síndrome psiquiátrica que causa significativa morbidade e mortalidade para pacientes internados e ambulatoriais tratados por profissionais de saúde mental...

  16. Immunohistochemical localization of four and a half LIM domains 2 in the odontoblasts of mature human teeth.

    Science.gov (United States)

    Wang, Xiaoying; Wang, Qiang; Wang, Li; Yang, Pishan

    2011-04-01

    Four and a half LIM domains 2 (FHL2) participates in cell differentiation and cancer development of various tissues, possessing dual functions either as an activator or as a repressor depending on the protein partners involved. Recent studies show that FHL2 plays an important role in osteoblast differentiation and bone formation. The present study was to investigate the expression and localization of FHL2 in human pulp-dentin complex by immunohistochemistry. Our results showed that in sound mature human teeth, FHL2 was expressed in odontoblasts and some endothelial cells of blood vessels. Moreover, in carious teeth FHL2 immunoreactivity was detected in odontoblasts, odontoblast-like cells and endothelial cells of blood vessels. FHL2 was mainly distributed in cytosol of the odontoblast cell bodies and partly located in nuclei of odontoblasts, but not in the odontoblast processes. Our data suggest a role of FHL2 in odontoblast differentiation and dentin formation both in normal and in carious teeth.

  17. Determinación de la Magnitud Local a partir de acelerogramas: Terremoto de Limón

    OpenAIRE

    Ramírez, Roberto; Laurent, Robert

    2011-01-01

    Este trabajo presenta el cálculo rápido de la magnitud Local del sísmo de Limón, a partir de acelerogramas del Programa de Medición de Sismos Fuertes del Laboratorio de Ingenieria Sísmica de la Universidad de Costa Rica. La Magnitud Local es una medida del tamaño de un terremoto, determinada para períodos cortos y a distancias relativamente pequeñas. Este parámetro es de interés para la ingeniería sismo-resistente y además se emplea en estudios de zonificación sísmica. La Magnitud Local del s...

  18. L’avenir des sabliers. Sur des poèmes de Sélim Baghli et de Farid Laroussi

    Directory of Open Access Journals (Sweden)

    Pierre Popovic

    2013-11-01

    Full Text Available Autant la poésie de Sélim Baghli peut être hachée, hésitante, inquiète d’elle-même, autant celle de Farid Laroussi frappe d’estoc, est assurée et ferme. Quand les vers de Baghli cooptent Verlaine, la prose de Laroussi affiche plus d’une accointance avec celle de Rimbaud. Cet article ne se propose pas de produire un brillant paradoxe à la manière des critiques littéraires vaporeux, mais d’essayer de comprendre comment des poèmes de Baghli et de Laroussi, en mettant à leur manière en scène un sujet qui résiste aux ravages du passé tout en étant dans le temps de l’après-coup, se trouvent plus ou moins travaillés par le thème de « l’Algérie malgré tout ». As much as Sélim Baghli’s poetry can be choppy, faltering, and self-conscious, Farid Laroussi’s is direct, self-assured and firm. Where Baghli’s verses co-opt Verlaine, Laroussi’s prose has a clear link to Rimbaud. This article does not attempt to illuminate an obvious paradox in the hazy style of literary critique, but instead it attempts to understand how the poems of Baghli and Laroussi portray, in their own way, a subject that resists the ravages of the past all the while existing in the post-coup era, finding themselves more or less shaped by the theme of “Algeria in spite of it all.”

  19. The terminal basal mitosis of chicken retinal Lim1 horizontal cells is not sensitive to cisplatin-induced cell cycle arrest.

    Science.gov (United States)

    Shirazi Fard, Shahrzad; Thyselius, Malin; All-Ericsson, Charlotta; Hallböök, Finn

    2014-01-01

    For proper development, cells need to coordinate proliferation and cell cycle-exit. This is mediated by a cascade of proteins making sure that each phase of the cell cycle is controlled before the initiation of the next. Retinal progenitor cells divide during the process of interkinetic nuclear migration, where they undergo S-phase on the basal side, followed by mitoses on the apical side of the neuroepithelium. The final cell cycle of chicken retinal horizontal cells (HCs) is an exception to this general cell cycle behavior. Lim1 expressing (+) horizontal progenitor cells (HPCs) have a heterogenic final cell cycle, with some cells undergoing a terminal mitosis on the basal side of the retina. The results in this study show that this terminal basal mitosis of Lim1+ HPCs is not dependent on Chk1/2 for its regulation compared to retinal cells undergoing interkinetic nuclear migration. Neither activating nor blocking Chk1 had an effect on the basal mitosis of Lim1+ HPCs. Furthermore, the Lim1+ HPCs were not sensitive to cisplatin-induced DNA damage and were able to continue into mitosis in the presence of γ-H2AX without activation of caspase-3. However, Nutlin3a-induced expression of p21 did reduce the mitoses, suggesting the presence of a functional p53/p21 response in HPCs. In contrast, the apical mitoses were blocked upon activation of either Chk1/2 or p21, indicating the importance of these proteins during the process of interkinetic nuclear migration. Inhibiting Cdk1 blocked M-phase transition both for apical and basal mitoses. This confirmed that the cyclin B1-Cdk1 complex was active and functional during the basal mitosis of Lim1+ HPCs. The regulation of the final cell cycle of Lim1+ HPCs is of particular interest since it has been shown that the HCs are able to sustain persistent DNA damage, remain in the cell cycle for an extended period of time and, consequently, survive for months.

  20. In vivo imaging of cell behaviors and F-actin reveals LIM-HD transcription factor regulation of peripheral versus central sensory axon development

    Directory of Open Access Journals (Sweden)

    Andersen Erica F

    2011-05-01

    Full Text Available Abstract Background Development of specific neuronal morphology requires precise control over cell motility processes, including axon formation, outgrowth and branching. Dynamic remodeling of the filamentous actin (F-actin cytoskeleton is critical for these processes; however, little is known about the mechanisms controlling motile axon behaviors and F-actin dynamics in vivo. Neuronal structure is specified in part by intrinsic transcription factor activity, yet the molecular and cellular steps between transcription and axon behavior are not well understood. Zebrafish Rohon-Beard (RB sensory neurons have a unique morphology, with central axons that extend in the spinal cord and a peripheral axon that innervates the skin. LIM homeodomain (LIM-HD transcription factor activity is required for formation of peripheral RB axons. To understand how neuronal morphogenesis is controlled in vivo and how LIM-HD transcription factor activity differentially regulates peripheral versus central axons, we used live imaging of axon behavior and F-actin distribution in vivo. Results We used an F-actin biosensor containing the actin-binding domain of utrophin to characterize actin rearrangements during specific developmental processes in vivo, including axon initiation, consolidation and branching. We found that peripheral axons initiate from a specific cellular compartment and that F-actin accumulation and protrusive activity precede peripheral axon initiation. Moreover, disruption of LIM-HD transcriptional activity has different effects on the motility of peripheral versus central axons; it inhibits peripheral axon initiation, growth and branching, while increasing the growth rate of central axons. Our imaging revealed that LIM-HD transcription factor activity is not required for F-actin based protrusive activity or F-actin accumulation during peripheral axon initiation, but can affect positioning of F-actin accumulation and axon formation. Conclusion Our ability

  1. LIMS/Nimbus-7 Level 3 Daily Vertical Profiles of O3, NO2, H2O, HNO3, Geopotential Height, and Temperature as 2deg Latitude Spaced Fourier Coefficients V006

    Data.gov (United States)

    National Aeronautics and Space Administration — The Limb Infrared Monitor of the Stratosphere (LIMS) version 6 Level-3 data product consists of daily, 2 degree zonal Fourier coefficients, of vertical profiles of...

  2. LIMS/Nimbus-7 Level 3 Daily 2 deg Latitude Zonal Fourier Coefficients of O3, NO2, H2O, HNO3, Geopotential Height, and Temperature V006 (LIMSN7L3) at GES DISC

    Data.gov (United States)

    National Aeronautics and Space Administration — The Limb Infrared Monitor of the Stratosphere (LIMS) version 6 Level-3 data product consists of daily, 2 degree zonal Fourier coefficients, of vertical profiles of...

  3. Evaluación de híbridos de papaya (carica papaya l. en pococí, limón, Costa Rica

    Directory of Open Access Journals (Sweden)

    Eric Mora

    2004-01-01

    Full Text Available Evaluación de híbridos de papaya (Carica papaya L. en Pococí, Limón, Costa Rica. Se estableció un experimento con nueve híbridos de papaya con el objetivo de determinar sus potenciales agronómicos y comerciales en una región de alta pluviosidad (cantón de Pococí, provincia de Limón. Las características evaluadas fueron tamaño de fruta, productividad total, brix de la pulpa y susceptibilidad a la antracnosis de la fruta causado por Colletotrichum gloesporioides. Se determinó que solo uno de los materiales mostró características similares al testigo comercial como fruta para consumo en fresco. Otro de los híbridos tuvo potencial para uso con fines agroindustriales.

  4. Automated washing of FTA Card punches and PCR setup for reference samples using a LIMS-controlled Sias Xantus automated liquid handler

    DEFF Research Database (Denmark)

    Stangegaard, Michael; Olsen, Addie Nina; Frøslev, Tobias G.

    2009-01-01

    We have implemented and validated automated methods for washing FTA Card punches containing buccal samples and subsequent PCR setup using a Sias Xantus automated liquid handler. The automated methods were controlled by worklists generated by our LabWare Laboratory Information Management System (L...... (LIMS). The protocols were validated according to EN/ISO 17025 for use with STR amplifications kits AmpFlSTR« Identifiler« and Y-filer« (Applied Biosystems)...

  5. Transcriptome and long noncoding RNA sequencing of three extracellular vesicle subtypes released from the human colon cancer LIM1863 cell line

    Science.gov (United States)

    Chen, Maoshan; Xu, Rong; Ji, Hong; Greening, David W.; Rai, Alin; Izumikawa, Keiichi; Ishikawa, Hideaki; Takahashi, Nobuhiro; Simpson, Richard J.

    2016-01-01

    Previously we reported that LIM1863 colorectal cancer (CRC) cells secrete three distinct extracellular vesicle subtypes – two subpopulations of exosomes (apical EpCAM-Exos and basolateral A33-Exos) and shed microvesicles (sMVs) – with distinct protein and miRNA signatures. Here, we extend our omics approach to understand the fundamental role of LIM1863-derived EVs by performing a comprehensive analysis of their mRNAs and long non-coding RNAs (lncRNAs) using RNA-Seq. We show that 2,389 mRNAs, 317 pseudogene transcripts, 1,028 lncRNAs and 206 short non-coding RNAs selectively distributed to (i.e., are enriched in) LIM1863 EVs, relative to the parent cell. An Ensembl/UniProtKB analysis revealed 1,937 mRNAs encode canonical proteins, 348 isoforms (including splice-variant proteins), and 119 ‘missing proteins’ (i.e., annotated in Ensembl but not UniProtKB). Further dissection of our protein/RNA data revealed that 6/151 observed RNA binding proteins have the potential to interact with ~75% of EV-enriched RNAs. Intriguingly, the co-existence of U1 and U2 ribonucleoproteins and their cognate snRNAs in LIM1863 EVs suggests a possible association of CRC EVs with recipient cell splicing events. Our data reveal several potential lncRNA CRC biomarkers and novel splicing/fusion genes that, collectively, will advance our understanding of EV biology in CRC and accelerate the development of EV-based diagnostics and therapeutics. PMID:27917920

  6. The US won the global currency war against Europe and Japan: Their retaliation likely helped elect Trump

    Directory of Open Access Journals (Sweden)

    Stephen P. Magee

    2017-11-01

    Full Text Available The United States financial community, lax regulations and the Fed started a global currency war in 2002. The inadvertent cheapening of the US dollar was a by-product of what became the US subprime lending crisis and the financial collapse in 2008. From 2002-2008, the Fed created so much liquidity that the dollar fell 33% relative to the yen and 40% relative to the euro. In response to the 2008 crash, the Fed had to ramp up US money creation again, generating $4 trillion in money creation by 2014. World interest rates fell and raw materials and commodity producers in emerging markets borrowed nearly $5 trillion. Overproduction and the slowdown of China caused a Third World oil and commodity market collapse around 2015. Beginning in 2014, other advanced countries retaliated and declared a global currency war of their own against United States. They created their money with a vengeance. Just as the US had done, this made the currencies of Europe, Japan and Britain 20 to 25% cheaper and their goods became more competitive relative to US goods. As a result, the US became the importer of last resort for cheap foreign goods from 2014 until the election in November of 2016. Only time will tell whether the US currency war that we won from 2002-2014 and the retaliation war we lost from 2014-2016 helped Trump get elected. The parallel is inescapable that the US also started the world tariff and trade war in 1930 with the passage of the Smoot Hawley tariff, which extended the length of the Great Depression. The US currency war pushed Japan even further into recession and weakened Europe. US quantitative easing became a beggar-thy-neighbor policy against our trading partners.

  7. Nuevo equipo de proceso de destilación fraccionada en continuo por arrastre con vapor de aceites esenciales del jugo de limón mexicano

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    Francisco J. Padilla M.

    2007-01-01

    Full Text Available En este trabajo se presenta un nuevo equipo llamado Destilador-Fraccionador Horizontal, para realizar el procesos de destilación fraccionada en continuo por arrastre de vapor de aceites esenciales obtenidos a partir del jugo de limón mexicano (Citrus aurantifolia. La capacidad de fraccionación del nuevo equipo es analizada con soluciones modelo y soluciones reales de jugo de limón. Se emplean diseños experimentales y métodos estadísticos para investigar el desempeño del equipo y para validar su capacidad de fraccionar. Mediante la determinación de la relación S/F (gramos de vapor necesario para extraer 1 g de aceite destilado en la fase vapor, se determina que el nuevo equipo requiere una menor cantidad de energía para lograr la separación de los aceites esenciales. Eficiencias de extracción de aceites esenciales superiores al 90% son alcanzadas empleando las soluciones reales de jugo de limón.

  8. Antibacterial activity of the marine sponge Ircinia Campana collected at Punta Uva Limón against Staphylococcus Aureus

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    Rafael Rojas Brenes

    2016-03-01

    Full Text Available The sponges are simple multicellularorganisms; they inhabit in marine environments from the polar seas to the tropical waterswhere they are more abundant. These species are exposed to large populations of microbes, reason that explains their complex morphological and cellular defense mechanism, which are used by these organisms to fight against pathogens. The purpose of this study was to evaluate the antibacterial activity of the marine sponge Ircinia campana, whichinhabits in the south of the Caribbean coast of Costa Rica against  Sthapylococcus aureus gram-positive bacteria. Sampleswere collected in Punta Uva in Limónduring July of 2007. The active compounds were obtainedby extraction with acetone (crude extract; and subsequently, chromatographic extracts were obtained using fractions 1:4 hexane: ethyl acetate. The antibacterial activities of the different fractions, including the  crude extract were tested.Our results suggest a zone of inhibition of 14.60 ±0.25 mm for the crude extract and18.70±0.25mm for the most active fraction separated by chromatography. The metabolite responsible for the antibacterial activity was isolated by High Performance Liquid Chromatography (HPLCand preliminarily characterized through ultraviolet (UV and infrared (IR spectroscopy.

  9. PEMAHAMAN HADITS TARBAWI BURHAN AL ISLAM AL ZARNUJI DALAM KITAB TA’LIM AL MUTA’ALLIM

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    Benny Afwadzi

    2017-01-01

    Full Text Available This paper explores the understanding of tarbawi (education hadith from one of the major influential clerics in the Islamic educational system, especially in pesantren. He is Burhan al Islam al Zarnuji with his landmark book Ta’lim al Muta’allim. The conclusion that can be drawn is that al Zarnuji has shades of sufistical view in understanding tarbawi hadith. This can be seen in his understanding of hadith on obligation to seek knowledge (thalab al ilmi faridhatun ‘ala kulli muslimin wa muslimatin, which is interpreted as ilm al hal, the science concerning the condition of the human religious or simplistically said as the religious sciences; and the hadith of intention of studying (innama al a’malu bi al niyyat with the intention for the sake of the hereafter and religion, not mundane. Such an understanding is not something taken for granted, but it can be reinterpreted and perfected in accordance with the spirit of the times of context.

  10. Comportamiento del cultivo del limón (citrus aurantifolia swingle en dos localidades de Santa Elena, Ecuador

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    Mercedes Santistevan

    2016-11-01

    Full Text Available Se realizó una investigación entre agosto y diciembre del 2015, con el objetivo de conocer el comportamiento del cultivo de limón (Citrus aurantifolia Swingle en dos localidades de la Provincia de Santa Elena, Ecuador. Se seleccionaron dos plantaciones de ocho años de edad, en Manglaralto y Colonche. En cada localidad se marcaron 50 plantas, en las que se hicieron las evaluaciones. El ensayo no tuvo un diseño experimental, pero el análisis estadístico se hizo como si fuera un Diseño Completamente al Azar (DCA, considerando cada localidad como un tratamiento y cada planta como una repetición. Se encontró que la mayor incidencia de plagas y enfermedades se presentó en Manglaralto. El mayor diámetro del fruto, correspondió a Colonche, con una diferencia estadísticamente significativa con respecto a Manglaralto. El mayor peso del fruto y el mayor rendimiento, correspondió a Colonche; pero las diferencias no fueron estadísticamente significativas con respecto a Manglaralto

  11. Hydroxyl radical recycling in isoprene oxidation driven by hydrogen bonding and hydrogen tunneling: the upgraded LIM1 mechanism.

    Science.gov (United States)

    Peeters, Jozef; Müller, Jean-François; Stavrakou, Trissevgeni; Nguyen, Vinh Son

    2014-09-25

    The Leuven isoprene mechanism, proposed earlier to aid in rationalizing the unexpectedly high hydroxyl radical (OH) concentrations in isoprene-rich, low-nitric-oxide (NO) regions ( Peeters ; et al. Phys. Chem. Chem. Phys . 2009 , 11 , 5935 ), is presented in an upgraded and extended version, LIM1. The kinetics of the crucial reactions in the proposed isoprene-peroxy radical interconversion and isomerization pathways are re-evaluated theoretically, on the basis of energy barriers computed at the much higher CCSD(T)/aug-cc-pVTZ//QCISD/6-311G(d,p) level of theory, and using multiconformer partition functions obtained at the M06-2X/6-311++G(3df,2p) level that, different from the B3LYP level used in our earlier work, accounts for the crucial London dispersion effects in the H-bonded systems involved. The steady-state fraction of the specific Z-δ-OH-peroxy radical isomers/conformers that can isomerize by a 1,6-H shift is shown to be largely governed by hydrogen-bond strengths, whereas their isomerization itself is found to occur quasi-exclusively by hydrogen atom tunneling. The isomer-specific Z-δ-OH-peroxy 1,6-H-shift rate coefficients are predicted to be of the order of 1 s(-1) at 298 K, but the experimentally accessible bulk rate coefficients, which have to be clearly distinguished from the former, are 2 orders of magnitude lower due to the very low Z-δ-OH-peroxy steady-state fractions that are only around or below 0.01 at low to moderate NO and depend on the peroxy lifetime. Two pathways subsequent to the peroxy radical 1,6-H shift are identified, the earlier predicted route yielding the photolabile hydroperoxy-methylbutenals (HPALDs), and a second, about equally important path, to dihydroperoxy-carbonyl peroxy radicals (di-HPCARP). Taking this into account, our predicted bulk peroxy isomerization rate coefficients are about a factor 1.8 higher than the available experimental results for HPALD production ( Crounse ; et al. Phys. Chem. Chem. Phys. 2011 , 13 , 13607

  12. Targeting nitrative stress for attenuating cisplatin-induced downregulation of cochlear LIM domain only 4 and ototoxicity

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    Samson Jamesdaniel

    2016-12-01

    Full Text Available Cisplatin-induced ototoxicity remains a primary dose-limiting adverse effect of this highly effective anticancer drug. The clinical utility of cisplatin could be enhanced if the signaling pathways that regulate the toxic side-effects are delineated. In previous studies, we reported cisplatin-induced nitration of cochlear proteins and provided the first evidence for nitration and downregulation of cochlear LIM domain only 4 (LMO4 in cisplatin ototoxicity. Here, we extend these findings to define the critical role of nitrative stress in cisplatin-induced downregulation of LMO4 and its consequent ototoxic effects in UBOC1 cell cultures derived from sensory epithelial cells of the inner ear and in CBA/J mice. Cisplatin treatment increased the levels of nitrotyrosine and active caspase 3 in UBOC1 cells, which was detected by immunocytochemical and flow cytometry analysis, respectively. The cisplatin-induced nitrative stress and apoptosis were attenuated by co-treatment with SRI110, a peroxynitrite decomposition catalyst (PNDC, which also attenuated the cisplatin-induced downregulation of LMO4 in a dose-dependent manner. Furthermore, transient overexpression of LMO4 in UBOC1 cells prevented cisplatin-induced cytotoxicity while repression of LMO4 exacerbated cisplatin-induced cell death, indicating a direct link between LMO4 protein levels and cisplatin ototoxicity. Finally, auditory brainstem responses (ABR recorded from CBA/J mice indicated that co-treatment with SRI110 mitigated cisplatin-induced hearing loss. Together, these results suggest that cisplatin-induced nitrative stress leads to a decrease in the levels of LMO4, downregulation of LMO4 is a critical determinant in cisplatin-induced ototoxicity, and targeting peroxynitrite could be a promising strategy for mitigating cisplatin-induced hearing loss.

  13. Dual role for LIM-HD gene Lhx2 in the formation of the lateral olfactory tract (LOT)

    Science.gov (United States)

    Saha, Bhaskar; Hari, Padmanabhan; Huilgol, Dhananjay; Tole, Shubha

    2007-01-01

    The development of the olfactory system in vertebrates is a multi-step process, in which several regulatory molecules are required at different stages. The development of the olfactory sensory epithelium and its projection to the olfactory bulb are both known to require LIM-HD transcription factor Lhx2. We examined whether Lhx2 plays a role in the development of the OB itself, and its projection to the olfactory cortex. Though there is no morphological OB protuberance in the Lhx2 mutant, mitral cells are normally specified and cluster in a displaced olfactory bulb-like structure (OBLS). The OBLS is not able to pioneer the LOT projection, in vivo or when provided control (host) telencephalic territory in an in vitro assay. Strikingly, the mutant OBLS is capable of projecting along the LOT, if provided with an existing normal LOT in the host explant. This is the first report of a role for a transcription factor expressed in the OB that selectively affects the axon guidance, but not the specification of mitral cells. Furthermore, the Lhx2 mutant lateral telencephalon does not support growth of a LOT projection from control OB explants. The defect correlates with the disruption of a cellular mechanism that is thought to be critical for LOT pathfinding: a specialized cell population, the “lot cells,” is mislocalized in the Lhx2 mutant. In addition, the expression of Sema6A is aberrantly upregulated. Together these findings reveal a dual role for Lhx2, in the OB as well as in the lateral telencephalon, for establishing the LOT projection. PMID:17329426

  14. Mitochondrial Translocation of High Mobility Group Box 1 Facilitates LIM Kinase 2-Mediated Programmed Necrotic Neuronal Death

    Science.gov (United States)

    Hyun, Hye-Won; Ko, Ah-Reum; Kang, Tae-Cheon

    2016-01-01

    High mobility group box 1 (HMGB1) acts a signaling molecule regulating a wide range of inflammatory responses in extracellular space. HMGB1 also stabilizes nucleosomal structure and facilitates gene transcription. Under pathophysiological conditions, nuclear HMGB1 is immediately transported to the cytoplasm through chromosome region maintenance 1 (CRM1). Recently, we have reported that up-regulation of LIM kinase 2 (LIMK2) expression induces HMGB1 export from neuronal nuclei during status epilepticus (SE)-induced programmed neuronal necrosis in the rat hippocampus. Thus, we investigated whether HMGB1 involves LIMK2-mediated programmed neuronal necrosis, but such role is not reported. In the present study, SE was induced by pilocarpine in rats that were intracerebroventricularly infused with saline, control siRNA, LIMK2 siRNA or leptomycin B (LMB, a CRM1 inhibitor) prior to SE induction. Thereafter, we performed Fluoro-Jade B staining, western blots and immunohistochemical studies. LIMK2 knockdown effectively attenuated SE-induced neuronal death and HMGB1 import into mitochondria accompanied by inhibiting nuclear HMGB1 release and abnormal mitochondrial elongation. LMB alleviated SE-induced neuronal death and nuclear HMGB1 release. However, LMB did not prevent mitochondrial elongation induced by SE, but inhibited the HMGB1 import into mitochondria. The efficacy of LMB was less effective to attenuate SE-induced neuronal death than that of LIMK2 siRNA. These findings indicate that nuclear HMGB1 release and the subsequent mitochondrial import may facilitate and deteriorate programmed necrotic neuronal deaths. The present data suggest that the nuclear HMGB1 release via CRM1 may be a potential therapeutic target for the programmed necrotic neuronal death induced by SE. PMID:27147971

  15. The LIM-only protein FHL2 mediates ras-induced transformation through cyclin D1 and p53 pathways.

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    Charlotte Labalette

    Full Text Available BACKGROUND: Four and a half LIM-only protein 2 (FHL2 has been implicated in multiple signaling pathways that regulate cell growth and tissue homeostasis. We reported previously that FHL2 regulates cyclin D1 expression and that immortalized FHL2-null mouse embryo fibroblasts (MEFs display reduced levels of cyclin D1 and low proliferative activity. METHODOLOGY/PRINCIPAL FINDINGS: Here we address the contribution of FHL2 in cell transformation by investigating the effects of oncogenic Ras in FHL2-null context. We show that H-RasV12 provokes cell cycle arrest accompanied by accumulation of p53 and p16(INK4a in immortalized FHL2(-/- MEFs. These features contrast sharply with Ras transforming activity in wild type cell lines. We further show that establishment of FHL2-null cell lines differs from conventional immortalization scheme by retaining functional p19(ARF/p53 checkpoint that is required for cell cycle arrest imposed by Ras. However, after serial passages of Ras-expressing FHL2(-/- cells, dramatic increase in the levels of D-type cyclins and Rb phosphorylation correlates with the onset of cell proliferation and transformation without disrupting the p19(ARF/p53 pathway. Interestingly, primary FHL2-null cells overexpressing cyclin D1 undergo a classical immortalization process leading to loss of the p19(ARF/p53 checkpoint and susceptibility to Ras transformation. CONCLUSIONS/SIGNIFICANCE: Our findings uncover a novel aspect of cellular responses to mitogenic stimulation and illustrate a critical role of FHL2 in the signalling network that implicates Ras, cyclin D1 and p53.

  16. LIM kinase1 modulates function of membrane type matrix metalloproteinase 1: implication in invasion of prostate cancer cells

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    Chakrabarti Ratna

    2011-01-01

    Full Text Available Abstract Background LIM kinase 1 (LIMK1 is an actin and microtubule cytoskeleton modulatory protein that is overexpressed in a number of cancerous tissues and cells and also promotes invasion and metastasis of prostate and breast cancer cells. Membrane type matrix metalloproteinase 1 (MT1-MMP is a critical modulator of extracellular matrix (ECM turnover through pericellular proteolysis and thus plays crucial roles in neoplastic cell invasion and metastasis. MT1-MMP and its substrates pro-MMP-2 and pro-MMP-9 are often overexpressed in a variety of cancers including prostate cancer and the expression levels correlate with the grade of malignancy in prostate cancer cells. The purpose of this study is to determine any functional relation between LIMK1 and MT1-MMP and its implication in cell invasion. Results Our results showed that treatment with the hydroxamate inhibitor of MT1-MMP, MMP-2 and MMP-9 ilomastat inhibited LIMK1-induced invasion of benign prostate epithelial cells. Over expression of LIMK1 resulted in increased collagenolytic activity of MMP-2, and secretion of pro-MMP2 and pro-MMP-9. Cells over expressing LIMK1 also exhibited increased expression of MT1-MMP, transcriptional activation and its localization to the plasma membrane. LIMK1 physically associates with MT1-MMP and is colocalized with it to the Golgi vesicles. We also noted increased expression of both MT1-MMP and LIMK1 in prostate tumor tissues. Conclusion Our results provide new information on regulation of MT1-MMP function by LIMK1 and showed for the first time, involvement of MMPs in LIMK1 induced cell invasion.

  17. Cloning, structural analysis, and chromosomal localization of the human CSRP2 gene encoding the LIM domain protein CRP2.

    Science.gov (United States)

    Weiskirchen, R; Erdel, M; Utermann, G; Bister, K

    1997-08-15

    The CSRP2 gene encoding the LIM domain protein CRP2 was originally identified in quail based on its strong transcriptional suppression in transformed avian fibroblasts. Here we have isolated a human CSRP2 cDNA clone encoding a 193-amino-acid human CRP2 (hCRP2) protein with 96.4% amino acid sequence identity to the avian homolog. The CSRP2 cDNA clone was used to isolate CSRP2-related clones from gamma EMBL3 and P1 libraries of human genomic DNA. The complete organization of the CSRP2 gene was determined by nucleic acid hybridization, transcriptional mapping, and nucleotide sequence analysis. The gene spans a total of approximately 22 kb and contains six exons. The coding region is confined to exons 2-6 and predicts a hCRP2 protein identical in its amino acid sequence to the protein deduced from the CSRP2 cDNA clone. By fluorescence in situ hybridization using both lambda EMBL3 and P1 library clones as hybridization probes and a new method for computerized signal localization, CSRP2 was mapped to chromosome subband 12q21.1, a region frequently affected by deletion or breakage events in various tumor types. The library screens also led to the isolation of a CSRP2-related pseudogene, CSRP2P, which carried several extensive deletions and nucleotide substitutions but no intervening sequences in comparison to the CSRP2 cDNA sequence. By physical linkage and fluorescence in situ hybridization, CSRP2P was mapped to chromosome subband 3q21.1.

  18. The structure of an LIM-only protein 4 (LMO4 and Deformed epidermal autoregulatory factor-1 (DEAF1 complex reveals a common mode of binding to LMO4.

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    Soumya Joseph

    Full Text Available LIM-domain only protein 4 (LMO4 is a widely expressed protein with important roles in embryonic development and breast cancer. It has been reported to bind many partners, including the transcription factor Deformed epidermal autoregulatory factor-1 (DEAF1, with which LMO4 shares many biological parallels. We used yeast two-hybrid assays to show that DEAF1 binds both LIM domains of LMO4 and that DEAF1 binds the same face on LMO4 as two other LMO4-binding partners, namely LIM domain binding protein 1 (LDB1 and C-terminal binding protein interacting protein (CtIP/RBBP8. Mutagenic screening analysed by the same method, indicates that the key residues in the interaction lie in LMO4LIM2 and the N-terminal half of the LMO4-binding domain in DEAF1. We generated a stable LMO4LIM2-DEAF1 complex and determined the solution structure of that complex. Although the LMO4-binding domain from DEAF1 is intrinsically disordered, it becomes structured on binding. The structure confirms that LDB1, CtIP and DEAF1 all bind to the same face on LMO4. LMO4 appears to form a hub in protein-protein interaction networks, linking numerous pathways within cells. Competitive binding for LMO4 therefore most likely provides a level of regulation between those different pathways.

  19. El Aceite esencial de limón producido en España. Contribución a su evaluación por Organismos Internacionales

    OpenAIRE

    Albaladejo Meroño, Querubina

    2000-01-01

    En este trabajo, además de las determinaciones habituales de características físico-químicas del aceite esencial de limón, se introducen las de color mediante el colorímetro digital, y de densidad, mediante densímetro electrónico. El estudio gascromatográfico, para determinar el orden de elución característico, se realiza en columnas capilares de sílice fundida: OV-101 apolar, CPWax-52-CB muy polar y HP-5 ligeramente polar. Comparando los resultados se logra la identificación de setenta y cua...

  20. Distribucion arborea de los gastropodos cerithidea montagnei (mollusca potamidae) y littorina Spp. (Mollusca, Littorinidae) en el manglar de Mata de Limón, Costa Rica

    OpenAIRE

    Suarez B, Édgar; Castaing R, Álvaro

    2016-01-01

    En el manglar de Mata de Limón, Puntarenas, Costa Rica, se estudió la distribución y preferencia por el susbtrato arbóreo de gastrópodos C. montagnei y Littorina spp. en cuatro especies de mangle, según la cantidad de moluscos observados en cada árbol y la cantidad de árboles con presencia o ausencia de ellos, en el período de setiembre de 1982 a junio de 1983. El orden de preferencia mostrado por ambos grupos de moluscos fue: 1) Rhizophora mangle, 2) Avicennia germinans, 3)Pelliciera rhizoph...

  1. Neotectonics and paleoseismology of the Limón and pedro miguel faults in Panamá: earthquake hazard to the Panamá canal

    Science.gov (United States)

    Rockwell, Thomas; Gath, Edon; Gonzalez, Tania; Madden, Chris; Verdugo, Danielle; Lippincott, Caitlin; Dawson, Tim; Owen, Lewis A.; Fuchs, Markus; Cadena, Ana; Williams, Pat; Weldon, Elise; Franceschi, Pastora

    2010-01-01

    We present new geologic, tectonic geomorphic, and geochronologic data on the slip rate, timing, and size of past surface ruptures for the right-lateral Lim??n and Pedro Miguel faults in central Panam??. These faults are part of a system of conjugate faults that accommodate the internal deformation of Panam?? resulting from the ongoing collision of Central and South America. There have been at least three surface ruptures on the Lim??n fault in the past 950-1400 years, with the most recent during the past 365 years. Displacement in this young event is at least 1.2 m (based on trenching) and may be 1.6-2 m (based on small channel offsets). Awell-preserved 4.2 m offset suggests that the penultimate event also sustained significant displacement. The Holocene slip rate has averaged about 6 mm=yr, based on a 30-m offset terrace riser incised into a 5-ka abandoned channel. The Pedro Miguel fault has sustained three surface ruptures in the past 1600 years, the most recent being the 2 May 1621 earthquake that partially destroyed Panam?? Viejo. At least 2.1 m of slip occurred in this event near the Canal, with geomorphic offsets suggesting 2.5-3 m. The historic Camino de Cruces is offset 2.8 m, indicating multimeter displacement over at least 20 km of fault length. Channel offsets of 100-400 m, together with a climate-induced incision model, suggest a Late Quaternary slip rate of about 5 mm=yr, which is consistent with the paleoseismic results. Comparison of the timing of surface ruptures between the Lim??n and Pedro Miguel faults suggests that large earthquakes may rupture both faults with 2-3 m of displacement for over 40 km, such as is likely in earthquakes in the M 7 range. Altogether, our observations indicate that the Lim??n and Pedro Miguel faults represent a significant seismic hazard to central Panam?? and, specifically, to the Canal and Panam?? City.

  2. Contexto y Caracterización de la Cadena de Suministro del Limón Persa (Citrus latifolia Tanaka) en Veracruz-México

    OpenAIRE

    Gregorio Fernández-Lambert; Alberto Antonio Aguilar-Lasserre; Gustavo Martínez-Castellanos; María Leocelia Guadalupe Ruvalcaba-Sánchez; Juan Gabriel Correa-Medina; José Luis Martínez-Flores

    2015-01-01

    Esta investigación se realiza en el Distrito Citrícola de Martínez de la Torre, Ver., con alcance a los municipios de Álamo Temapache, y Cuitláhuac en Veracruz, y reporta el contexto e integración de la cadena de suministro del limón persa. El estudio de sus eslabones permitió identificar las problemáticas de abastecimiento, operación y distribución en dicha cadena. A partir de entrevistas abiertas no estructuradas a especialistas, técnicos, productores y empresarios, así como la consult...

  3. Heterogenic final cell cycle by chicken retinal Lim1 horizontal progenitor cells leads to heteroploid cells with a remaining replicated genome.

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    Shahrzad Shirazi Fard

    Full Text Available Retinal progenitor cells undergo apical mitoses during the process of interkinetic nuclear migration and newly generated post-mitotic neurons migrate to their prospective retinal layer. Whereas this is valid for most types of retinal neurons, chicken horizontal cells are generated by delayed non-apical mitoses from dedicated progenitors. The regulation of such final cell cycle is not well understood and we have studied how Lim1 expressing horizontal progenitor cells (HPCs exit the cell cycle. We have used markers for S- and G2/M-phase in combination with markers for cell cycle regulators Rb1, cyclin B1, cdc25C and p27Kip1 to characterise the final cell cycle of HPCs. The results show that Lim1+ HPCs are heterogenic with regards to when and during what phase they leave the final cell cycle. Not all horizontal cells were generated by a non-apical (basal mitosis; instead, the HPCs exhibited three different behaviours during the final cell cycle. Thirty-five percent of the Lim1+ horizontal cells was estimated to be generated by non-apical mitoses. The other horizontal cells were either generated by an interkinetic nuclear migration with an apical mitosis or by a cell cycle with an S-phase that was not followed by any mitosis. Such cells remain with replicated DNA and may be regarded as somatic heteroploids. The observed heterogeneity of the final cell cycle was also seen in the expression of Rb1, cyclin B1, cdc25C and p27Kip1. Phosphorylated Rb1-Ser608 was restricted to the Lim1+ cells that entered S-phase while cyclin B1 and cdc25C were exclusively expressed in HPCs having a basal mitosis. Only HPCs that leave the cell cycle after an apical mitosis expressed p27Kip1. We speculate that the cell cycle heterogeneity with formation of heteroploid cells may present a cellular context that contributes to the suggested propensity of these cells to generate cancer when the retinoblastoma gene is mutated.

  4. Efecto de precursores y reguladores de crecimiento en la formación de brotes adventicios a partir de explantes de limón persa (Citrus latifolia).

    OpenAIRE

    Pérez Luna, Adriana Isabel

    2013-01-01

    En México, la citricultura se ha visto afectada por diferentes plagas y enfermedades, ocasionando grandes daños en la producción. Limón persa (Citrus latifolia Tan.) por ser un cítrico agrio está catalogado como una especie susceptible a una de las enfermedades más devastadoras como lo es el Huanglongbing (HLB). Una alternativa viable es el desarrollo de plantas transgénicas resistentes a enfermedades. Para ello se requiere un protocolo eficiente de brotación adventicia. En este estudio se c...

  5. Evaluación de factores en cosecha y de manejo postcosecha que inciden en la calidad de frutos de limón mexicano (Citrus aurantifolia Swingle)

    OpenAIRE

    Rodríguez Novoa, Froylán

    2012-01-01

    Durante el manejo postcosecha de de limón mexicano (Citrus aurantifolia Swingle) existen diversos problemas, que deterioran la calidad de la fruta reflejándose en el cambio de color, perdidas de peso (marchitamiento), incidencia o aparición de desordenes fisiológicos, daños mecánicos, además de las perdidas de la calidad organoléptica y nutricional por lo tanto no es muy factible su llegada a mercados de exportación (Escalante et al., 2003) El maltrato de la frut...

  6. Propuesta para la creación de un centro de compras de farmacias en la provincia de Limón

    OpenAIRE

    Lao Joa, Ana Isabel

    2009-01-01

    Tesis de maestría -- Universidad de Costa Rica. Posgrado en Administración y Dirección de Empresas. Maestría Profesional en Administración y Dirección de Empresas, 2009 El objetivo general del trabajo es proponer la creación de un centro de compras de farmacias en la provincia de Limón con la finalidad de obtener mejores descuentos en los medicamentos y poder competir contra las grandes cadenas. La organización investigada es una farmacia y se dedica a la venta de medicamentos. ...

  7. Effects of different agricultural systems on soil quality in Northern Limón province, Costa Rica

    Directory of Open Access Journals (Sweden)

    Emma Cornwell

    2014-09-01

    Full Text Available Conversion of native rainforest ecosystems in Limón Province of Costa Rica to banana and pineapple monoculture has led to reductions in biodiversity and soil quality. Agroforestry management of cacao (Theobroma cacao is an alternative system that may maintain the agricultural livelihood of the region while more closely mimicking native ecosystems. This study compared physical, biological and chemical soil quality indicators of a cacao plantation under organic agroforestry management with banana, pineapple, and pasture systems; a native forest nearby served as a control. For bulk density and earthworm analysis, 18 samples were collected between March and April 2012 from each ecosystem paired with 18 samples from the cacao. Cacao had a lower bulk density than banana and pineapple monocultures, but greater than the forest (p<0.05. Cacao also hosted a greater number and mass of earthworms than banana and pineapple (p<0.05, but similar to forest and pasture. For soil chemical characteristics, three composite samples were collected in March 2012 from each agroecosystem paired with three samples from the cacao plantation. Forest and pineapple ecosystems had the lowest pH, cation exchange capacity, and exchangeable nutrient cations, while cacao had the greatest (p<0.05. Total nutrient levels of P and N were slightly greater in banana, pineapple and pasture than in cacao; probably related to addition of chemical fertilizer and manure from cattle grazing. Forest and cacao also had greater %C, than other ecosystems, which is directly related to soil organic matter content (p<0.0001. Overall, cacao had more favorable physical, biological and chemical soil characteristics than banana and pineapple monocultures, while trends were less conclusive compared to the pastureland. While organic cacao was inferior to native forest in some soil characteristics such as bulk density and organic carbon, its soil quality did best mimic that of the native forest. This

  8. Armazenamento refrigerado de limões 'Siciliano' tratados com etileno Cold storage of 'Siciliano' lemon treated with ethylene

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    Angelo Pedro Jacomino

    2003-04-01

    Full Text Available O objetivo deste experimento foi avaliar o efeito do tratamento com etileno na conservação refrigerada de limão 'Siciliano'. As frutas foram tratadas com 0; 3; 6 e 12 µL.L-1 de etileno durante 2; 4 ou 6 dias a 20oC. Após os tratamentos, os frutos foram armazenados a 10oC e 90% UR durante 35 dias, e avaliados após 21; 28 e 35 dias. O desverdecimento das frutas ocorreu mais rapidamente à medida que a concentração de etileno e o tempo dos tratamentos foram aumentados. Entretanto, tratamento por 6 dias na concentração de 12µL.L-1 causou podridão nas frutas após 35 dias de armazenamento refrigerado. Não houve efeitos dos tratamentos sobre o teor de sólidos solúveis totais, acidez total titulável, perda de matéria fresca e porcentagem de suco. O tratamento mais recomendado é a aplicação de 6µL.L-1 de etileno durante 4 dias.The objective of this experiment was to evaluate the effect of ethylene treatments upon cold storage of 'Siciliano' lemons. Fruit were treated with 0, 3, 6 or 12µL.L-1 of ethylene during 2,4 or 6 days at 20oC. After treatments, fruit were cold stored at 10oC and 90% RH during 35 days, and evaluated after 21, 28 and 35 days of storage. The degreening was more fasten so far as the ethylene concentration and duration of treatment were increased. However, treatment for 6 days and ethylene concentration of 12µL.L-1 caused decay in fruits after 35 days of cold storage. There was no effect of treatments in the soluble solids content, acidity total titratable, weight loss and juice percentage. Ethylene at 6µL.L-1 during 4 days is the recommendation to degreening of this cultivar.

  9. Proyecto de exportación de aceite esencial de limón con destino a los países miembros del nafta: una alternativa para competir en el tlc

    OpenAIRE

    Borbor Bermeo, Jose; Cadena Piedrahita, Luisana; Mejia Coronel, Marco Tulio

    2009-01-01

    El objetivo del proyecto es determinar la viabilidad técnica y económica de la instalación de una planta para la extracción de aceite esencial de limón en nuestro país. El estudio consta de cinco capítulos: Situación Nacional del Limón, Mercado Mundial, Estudio Técnico, Estudio Financiero y el Análisis del Impacto Ambiental. En el primer capítulo se detalla un estudio sobre las particularidades que existen en el cultivo de limón, además se explica la importancia económica y geográfica que...

  10. Estudio logístico en la empresa COMERFRUTAS de Colombia S.A.S para la exportación de pulpa de limón al mercado holandés

    OpenAIRE

    Piedrahita Bravo, Carlos Hernán; Marín Ríos, Esteban

    2012-01-01

    El presente documento ofrece una guía logística y análisis financiero para las pequeñas y medianas empresas (PyMES) de Colombia que deseen exportar pulpa de limón al mercado Europeo. Para el desarrollo de este trabajo se ha tomado el caso de la micro empresa COMERFRUTAS de Colombia S.A.S. (productora de pulpa de limón) y se ha realizado un estudio de competitividad de puertos, agentes de carga tanto terrestre como marítimos para dar las bases necesarias de exportación a las PyMES colombianas ...

  11. Produção de mudas de capim-limão em diferentes recipientes e substratos Transplant production of lemon grass in different recipients and substrates

    Directory of Open Access Journals (Sweden)

    Arie F Blank

    2009-12-01

    Full Text Available Os efeitos de recipientes e misturas de substratos, diâmetros de perfilho e comprimentos de lâmina foliar mantida no perfilho foram avaliados para produção de mudas de capim-limão (Cymbopogon citratus (D.C. Stapf.. No primeiro ensaio testaram-se dois recipientes e nove misturas de substratos. Os substratos avaliados foram pó de coco, casca de arroz carbonizada e esterco bovino na proporção 1:1:2; pó de coco, casca de arroz carbonizada, solo e esterco bovino na proporção 1:1:1:3. O recipiente tubete de 110 cm³ foi melhor que a bandeja de poliestireno expandido com 72 células de 121,2 cm³ para a produção de mudas de capim-limão. Todos os substratos testados resultaram na produção de mudas de capim-limão de boa qualidade. No segundo ensaio, foram testados dois diâmetros de perfilho (>1,5 e The effect of recipients, substrate mixtures, diameters of tillers and of different leaf lengths kept on the tiller was evaluated for transplant production of lemon grass (Cymbopogon citratus (D.C. Stapf.. In the first assay, we tested two recipients and nine mixtures of substrates. The tublet recipient of 110 cm3 was better than the expanded polystyrene foam bed with 72 cells of 121.2 cm3 and all the tested substrates (coconut dust, carbonized rice hulls and bovine manure at rates of 1:1:2, and coconut dust, carbonized rice hulls, soil and bovine manure at rates of 1:1:1:3 resulted in good quality of lemon grass transplants. In the second assay, we tested two tiller diameters (>1.5 and <1.5 cm and the maintenance of four leaf lengths on tiller (0, 3, 6 and 9 cm. It was concluded that if tillers were thicker than 1.5 cm diameter, then 5.5 cm of leaf length should be kept and if the tiller diameter were inferior to 1.5 cm, then the total leaf area should be cut off in order to promote tilling.

  12. Potencial antioxidante de extratos de sementes de limão (Citrus limon Antioxidant potential of lemon seed extracts (Citrus limon

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    Débora Maria Moreno Luzia

    2010-06-01

    Full Text Available O presente trabalho teve como principais objetivos avaliar o comportamento do óleo de soja acrescido de extratos de sementes de limão (Citrus limon, em diferentes concentrações, por meio da estabilidade oxidativa e medir a atividade antioxidante através do método do radical livre DPPH e compostos fenólicos totais. A concentração de 2.400 mg.kg-1 para o extrato de sementes de limão, variedade galego, foi a que conferiu melhor estabilidade oxidativa ao óleo de soja. As atividades antioxidantes máximas e os valores da concentração de extrato natural suficientes para obter 50% do efeito máximo, estimado em 100% (EC50, determinados pelo DPPH para o extrato e ácido gálico foram 70,58%, 69,94 μg.mL-1 e 75,07%, 64,73 μg.mL-1, respectivamente. A concentração de compostos fenólicos totais, determinada pelo método de Folin-Ciocalteu foi de 76 mg.g-1. Foi possível concluir que o extrato de sementes de limão galego possui ação antioxidante natural, podendo ser aplicado em alimentos.The present study aimed at evaluating the behavior of the soybean oil with the addition of lemon seed extracts (Citrus limon, in different concentrations, through oxidative stability and also at measuring the antioxidant activity using the DPPH free radical method and total phenolic compounds. The concentration of 2,400 mg.kg-1 for the lemon seed extract, galego variety, was the one that provided the soybean oil with the best oxidative stability. The maximum antioxidant activities and the concentration values of the natural extract sufficient to obtain 50% of maximum effect, estimated at 100% (EC50, determined by DPPH for the extract and gallic acid were 70.58%, 69.94 μg.mL-1 and 75.07%, 64.73 μg.mL-1, respectively. The concentration of total phenolic compounds, determined by the Folin-Ciocalteu method, was of 76 mg.g-1. Thus, it can be said that the lemon seed extract, galego, presents natural antioxidant action demonstrating potential to be used in

  13. Deep sequencing of RNA from three different extracellular vesicle (EV subtypes released from the human LIM1863 colon cancer cell line uncovers distinct miRNA-enrichment signatures.

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    Hong Ji

    Full Text Available Secreted microRNAs (miRNAs enclosed within extracellular vesicles (EVs play a pivotal role in intercellular communication by regulating recipient cell gene expression and affecting target cell function. Here, we report the isolation of three distinct EV subtypes from the human colon carcinoma cell line LIM1863--shed microvesicles (sMVs and two exosome populations (immunoaffinity isolated A33-exosomes and EpCAM-exosomes. Deep sequencing of miRNA libraries prepared from parental LIM1863 cells/derived EV subtype RNA yielded 254 miRNA identifications, of which 63 are selectively enriched in the EVs--miR-19a/b-3p, miR-378a/c/d, and miR-577 and members of the let-7 and miR-8 families being the most prominent. Let-7a-3p*, let-7f-1-3p*, miR-451a, miR-574-5p*, miR-4454 and miR-7641 are common to all EV subtypes, and 6 miRNAs (miR-320a/b/c/d, miR-221-3p, and miR-200c-3p discern LIM1863 exosomes from sMVs; miR-98-5p was selectively represented only in sMVs. Notably, A33-Exos contained the largest number (32 of exclusively-enriched miRNAs; 14 of these miRNAs have not been reported in the context of CRC tissue/biofluid analyses and warrant further examination as potential diagnostic markers of CRC. Surprisingly, miRNA passenger strands (star miRNAs for miR-3613-3p*, -362-3p*, -625-3p*, -6842-3p* were the dominant strand in A33-Exos, the converse to that observed in parental cells. This finding suggests miRNA biogenesis may be interlinked with endosomal/exosomal processing.

  14. Primeira ocorrência de ferrugem em capim-limão causada por Puccinia cymbopogonis no Brasil First report of the lemongrass rust fungi caused by Puccinia cymbopogonis in Brazil

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    João Batista Vida

    2006-03-01

    Full Text Available È registrada a primeira ocorrência de ferrugem em capim-limão (Cymbopogon citratus (DC. Stapf, causada por Puccinia cymbopogonis Mass., no Brasil, Estado do Paraná.It is reported the first occurrence of the lemongrass (Cymbopogon citratus (DC. Stapf rust fungi caused by Puccinia cymbopogonis Mass. in Brazil, State of Paraná.

  15. ambiental de agricultores orgánicos y convencionales en el ejido La Ciénega, municipio de El Limón, Jalisco, México

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    Rodolfo González-Figueroa

    2007-01-01

    Full Text Available La agricultura moderna en México está causando contaminación y erosión; de ello deriva la creciente pobreza y marginación que se padece en diversas zonas rurales, donde la cultura y el sustento dependen de la agricultura. Entender y responder al fenómeno de la degradación ambiental implica comprender las ideas, valores y esperanzas de los campesinos y, a partir de ello, construir alternativas. En este artículo se presentan cuatro estudios de caso en el ejido de La Ciénega, municipio El Limón, en la región Costa Sur de Jalisco, México, buscando contextualizar estos casos en el debate sobre el desarrollo sustentable.

  16. Distribucion arborea de los gastropodos cerithidea montagnei (mollusca potamidae y littorina Spp. (Mollusca, Littorinidae en el manglar de Mata de Limón, Costa Rica

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    Édgar Suarez B

    2016-03-01

    Full Text Available En el manglar de Mata de Limón, Puntarenas, Costa Rica, se estudió la distribución y preferencia por el susbtrato arbóreo de gastrópodos C. montagnei y Littorina spp. en cuatro especies de mangle, según la cantidad de moluscos observados en cada árbol y la cantidad de árboles con presencia o ausencia de ellos, en el período de setiembre de 1982 a junio de 1983. El orden de preferencia mostrado por ambos grupos de moluscos fue: 1 Rhizophora mangle, 2 Avicennia germinans, 3Pelliciera rhizophorae y 4 Laguncularia racemosa. Se discuten las posibles razones de esta preferencia. Cerithidea montagnei presentó una mayor distribución horizontal, así como una mayor abundancia respecto de Littorina spp.

  17. Tratamento farmacológico do transtorno de personalidade limítrofe: revisão crítica da literatura e desenvolvimento de algoritmos Tratamiento farmacológico del trastorno de personalidad limítrofe: revisión crítica de la literatura y desarrollo de algoritmos Pharmacological treatment of borderline personality disorder: critical review of the literature and development of algorithms

    National Research Council Canada - National Science Library

    André F. Carvalho; Cristiane B. Stracke; Fábio G. de Matos e Souza

    2004-01-01

    INTRODUÇÃO: O transtorno de personalidade limítrofe (TPL) é uma síndrome psiquiátrica que causa significativa morbidade e mortalidade para pacientes internados e ambulatoriais tratados por profissionais de saúde mental...

  18. First-in-man study of dedicated bifurcation cobalt-chromium sirolimus-eluting stent BiOSS LIM C - 3-month results.

    Science.gov (United States)

    Gil, Robert J; Bil, Jacek; Kern, Adam; Pawłowski, Tomasz

    2017-12-01

    The optimal approach to coronary bifurcations treatment by PCI is still a subject of debate and the dedicated bifurcation stents are one of proposed solutions. The aim of this report was to assess effectiveness and safety profile of a new dedicated bifurcation stent - sirolimus-eluting BiOSS® LIM C (Balton, Poland) at the first 3 months of the 12-month Registry. This is the two-center registry, which enrolls patients with NSTE-ACS and stable angina. Provisional T-stenting is the obligatory strategy of the treatment. Angiographic control is planned at 12 months. The primary endpoint is the cumulative rate of cardiac death, myocardial infarction (MI) and target lesion revascularization (TLR) at 12 months. A total of 48 patients with lesions in coronary bifurcations were enrolled (mean age 67.9±8.9 years, 14.6% of female). There were 20.8% of patients with NSTE-ACS, 93.8% with hypertension, 35.4% with diabetes, 52.1% had previous MI, and 47.9% and 14.6% underwent prior PCI and CABG, respectively. The device success rate was 100%. The side branch was treated with an additional classical DES implantation in 18.8% of cases. The periprocedural MI (MI type 4a) was observed in two cases (4.2%). At 3 months there was one case (2.1%) of TLR. No death, MI or stent thrombosis were observed. Bifurcation treatment with a single dedicated bifurcation stent (BiOSS LIM C) is feasible and highly successful (100% implantation success rate). The short-term clinical results are very promising, also in distal left main stenosis. The 12-month observations are pending.

  19. A mutant CHS3 protein with TIR-NB-LRR-LIM domains modulates growth, cell death and freezing tolerance in a temperature-dependent manner in Arabidopsis.

    Science.gov (United States)

    Yang, Haibian; Shi, Yiting; Liu, Jingyan; Guo, Lin; Zhang, Xiaoyan; Yang, Shuhua

    2010-07-01

    Low temperature is one of environmental factors that restrict plant growth homeostasis and plant-pathogen interactions. Recent studies suggest a link between temperature responses and defense responses; however, the underlying molecular mechanisms remain unclear. In this study, the chilling sensitive 3 (chs3-1) mutant in Arabidopsis was characterized. chs3-1 plants showed arrested growth and chlorosis when grown at 16 degrees C or when shifted from 22 to 4 degrees C. chs3-1 plants also exhibited constitutively activated defense responses at 16 degrees C, which were alleviated at a higher temperature (22 degrees C). Map-based cloning of CHS3 revealed that it encodes an unconventional disease resistance (R) protein belonging to the TIR-NB-LRR class with a zinc-binding LIM domain (Lin-11, Isl-1 and Mec-3 domains) at the carboxyl terminus. The chs3-1 mutation in the conserved LIM-containing domain led to the constitutive activation of the TIR-NB-LRR domain. Consistently, the growth and defense phenotypes of chs3-1 plants were completely suppressed by eds1, sgt1b and rar1, partially by pad4 and nahG, but not by npr1 and ndr1. Intriguingly, chs3-1 plants grown at 16 degrees C showed enhanced tolerance to freezing temperatures. This tolerance was correlated with growth defect and cell death phenotypes caused by activated defense responses. Other mutants with activated defense responses, including cpr1, cpr5 and slh1 also displayed enhanced freezing tolerance. These findings revealed a role of an unconventional mutant R gene in plant growth, defense response and cold stress, suggesting a mutual interaction between cold signaling and defense responses.

  20. Parasitosis intestinal en monos capuchinos cariblancos Cebus capucinus (Primates: Cebidae de un área protegida en la provincia de Limón, noreste de Costa Rica

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    Misael Chinchilla

    2010-12-01

    Full Text Available La deforestación de bosques tropicales está amenazando la biodiversidad de las especies de primates y su estado de salud, dependiente de un lugar ecológicamente equilibrado. Con el fin de evaluar esta relación, se analizó la presencia de parásitos en los intestinos de esta especie. El estudio se realizó en la Estación Biológica La Suerte (EBLS, Limón, Costa Rica. El grupo de monos capuchinos cariblancos (Cebus capucinus fue observado entre marzo y diciembre de 2006. Se recolectaron 75 muestras de heces a las que se les identificó las plantas ingeridas, y se procesaron en el laboratorio para evaluar la prevalencia de parásitos. Moraceae fue la familia de plantas más reportada. Strongyloides spp. y acantocéfalos fueron los más comunes. La distribución positiva de las mismas fue similar independientemente del sexo y la edad. Microsporidios se reportaron mayoritariamente en heces asociadas con la familia Piperaceae. Fue encontrada una baja existencia de éstos parásitos en muestras asociadas con Myrtaceae en cuyo género Psidium, se han reportado compuestos activos antiparasitarios. La aparición de parásitos fue relativamente mayor en la EBLS, comparado con muestras de otras regiones más secas de Costa Rica. Por lo tanto, esa expresión parasitaria puede deberse al hecho de ser la EBLS una selva lluviosa, además de estar rodeada por zonas con actividades antrópicas. Se sugiere incrementar las investigaciones de parasitología de campo en primates neotropicales con el fin de entender plenamente las relaciones parásitos-hospederos, para en un largo plazo poder comprender los ecosistemas donde conviven, y en consecuencia, preservar la diversidad biológica.Intestinal parasites in white-faced capuchin monkeys Cebus capucinus Primates: Cebidae inhabiting a protected area in the Limón province of Northeastern Costa Rica. Deforestation of tropical forests is threatening monkey biodiversity and their health status, dependent of an

  1. Neogene-quaternary Ostracoda and paleoenvironments, of the Limón basin, Costa Rica, and Bocas del Toro basin, Panama

    Science.gov (United States)

    Borne, P.F.; Cronin, T. M.; Hazel, J.E.

    1999-01-01

    Tropical marine ostracodes from Neogene and Quaternary sediments of the Central American Caribbean region have been the subject of biostratigraphic, ecological, taxonomic, and evolutionary studies. As part of the Panama Paleontology Project (PPP), Neogene and Quaternary ostracodes are being studied from the Central American region. The overall goal of this research is to evaluate the impact of the emergence of the Central American Isthmus as a land barrier between the Caribbean/tropical Atlantic and the Pacific oceans on marine ostracode biodiversity and the oceanic environments in which extant ostracodes evolved. Due to the ecological specificity of many living tropical ostracode species, they are ideally suited for reconstructing paleoenvironments on the basis of their occurrence in fossil assemblages, which in turn can lead to a better understanding of the tropical climatic and tectonic history of Central America. The principal aims of this chapter are: (a) to document the composition of the ostracode assemblages from the Limón Basin of Costa Rica and the Bocas del Toro Basin of Panama, two areas yielding extensive ma rine ostracode assemblages; (b) to describe the environments of deposition within these basins; and (c) to document the stratigraphic distribution of potentially agediagnostic ostracode species in the Limón and Bocas del Toro basins in order to enhance their use in Central American biostratigraphy. A secondary, but none-the-less important goal is to assemble a database on the distribution of modem ostracode species in the Caribbean and adjacent areas as a basis for comparison with fossil assemblages. Although the ecological, biostratigraphic and paleoenvironmental conclusions presented here will improve as additional material is studied, these fossil and modem ostracode databases constitute the foundation for future evolutionary and geochernical studies of tropical Caribbean and eastern Pacific Ocean ostracodes. Moreover, we present here evidence

  2. Corrosión atmosférica en ambientes abrigados en Limón, Costa Rica, en el marco del proyecto TROPICORR

    Directory of Open Access Journals (Sweden)

    Juan Fernando Alvarez

    2008-04-01

    Full Text Available Se estudia la corrosión atmosférica en ambientes abrigados (INDOOR en Limón, Puerto en el Atlántico de Costa Rica, de diferentes materiales utilizados en la industria electro-electrónica (acero, cobre, estaño y zinc y se compara con valores de corrosión en las mismas condicionesen otras zonas. El estudio está en el marco del proyecto internacional denominado TROPICORR del CYTED, en el cual se participa, y que tiene como interés estudiar la corrosión de materiales metálicos utilizados en la industria electro-electrónica en ambientes tropicales. Las condicionesque afectan a la corrosión atmosférica son: la temperatura, la humedad, el tiempo de humectación (donde la temperatura es mayor a 0 ºC y 80% HR y contaminantes, especialmente cloruros y SO2. En el caso del presente estudio estos efectos son evidentes en Costa Rica, ubicada en la latitud 10º Norte, y por su ubicación geográfica, entre dos océanos y con una formación montañosa en el centro del país, en donde se encuentran varios volcanes.En Limón, se tienen temperaturas mayores a 0 ºC todo el año y humedades elevadas, así como contaminantes de cloruros por estar situado en la costa y además, en la estación del estudio SO2 por efectos particulares. La metodología de estudio corresponde al tipo 3-4 de la norma ETS y a la norma ISO 85653, y se presentan los resultados obtenidos en tres años deestudio. También se compara tanto para el acero como para el cobre el efecto de ser expuesta las muestras tanto a la intemperie como en condiciones abrigadas.

  3. Lesiones cerebrales en áreas limítrofes e infartos hemodinámicos. Evaluación con imágenes diagnósticas

    Directory of Open Access Journals (Sweden)

    Julio Mario Araque G.

    1999-04-01

    Full Text Available La clasificación de los infartos cerebrales, desde el punto de vista de las imágenes diagnósticas, se basa fundamentalmente en la localización, tamaño y forma en que se evidencia el daño parenquimatoso en los estudios de Resonancia Magnética (RM o de Tomografía Axial Computadorizada (TAC (1,2. Con los mencionados exámenes se pueden diferenciar infartos territoriales de infartos limítrofes, lo cual tiene implicaciones pronósticas y de tratamiento, pues las lesiones en áreas limítrofes implican un compromiso más severo de la hemodinámica global del paciente (3 y se asocian frecuentemente a lesiones significativas de vasos intra o extracraneanos o enfermedad sistémica.

  4. Determinación del coeficiente global de transferencia de calor en secaderos rotativos de cáscara de limón Determination of global heat transfer coefficient in lemon peel rotary dryers

    Directory of Open Access Journals (Sweden)

    Marcos A. Golato

    2005-12-01

    Full Text Available En la bibliografía consultada no se encontraron trabajos de secado de cáscara de limón en secaderos rotativos. Se realizaron ensayos de medición en secaderos rotativos de cáscara de limón en una instalación agroindustrial del noroeste argentino. Se desarrolló un modelo matemático semiempírico mediante la resolución de los balances de materia y energía. Se obtuvo una correlación estadística para la predicción de los coeficientes globales volumétricos de transferencia de calor aparentes para secaderos rotativos de cáscara de limón.No papers on lemon peel drying in rotary dryers were actually found in the sources consulted. Measurement tests were carried out in the assessment of rotary dryer systems used to dehydrate lemon peel in an agroindustrial plant of Northwestern Argentina. A semiempirical mathematic model was developed solving mass and energy balances. A statistical correlation for predicting global heat transfer coefficient in rotary dryer lemon peel dehydration was obtained.

  5. Modulation of light-driven arousal by LIM-homeodomain transcription factor Apterous in large PDF-positive lateral neurons of the Drosophila brain.

    Science.gov (United States)

    Shimada, Naoto; Inami, Show; Sato, Shoma; Kitamoto, Toshihiro; Sakai, Takaomi

    2016-11-17

    Apterous (Ap), the best studied LIM-homeodomain transcription factor in Drosophila, cooperates with the cofactor Chip (Chi) to regulate transcription of specific target genes. Although Ap regulates various developmental processes, its function in the adult brain remains unclear. Here, we report that Ap and Chi in the neurons expressing PDF, a neuropeptide, play important roles in proper sleep/wake regulation in adult flies. PDF-expressing neurons consist of two neuronal clusters: small ventral-lateral neurons (s-LNvs) acting as the circadian pacemaker and large ventral-lateral neurons (l-LNvs) regulating light-driven arousal. We identified that Ap localizes to the nuclei of s-LNvs and l-LNvs. In light-dark (LD) cycles, RNAi knockdown or the targeted expression of dominant-negative forms of Ap or Chi in PDF-expressing neurons or l-LNvs promoted arousal. In contrast, in constant darkness, knockdown of Ap in PDF-expressing neurons did not promote arousal, indicating that a reduced Ap function in PDF-expressing neurons promotes light-driven arousal. Furthermore, Ap expression in l-LNvs showed daily rhythms (peaking at midnight), which are generated by a direct light-dependent mechanism rather than by the endogenous clock. These results raise the possibility that the daily oscillation of Ap expression in l-LNvs may contribute to the buffering of light-driven arousal in wild-type flies.

  6. Chemical obtaining of LiMO2 and LiM2O4 (M=Co, Mn) oxides, for cathodic applications in Li-ion batteries

    Science.gov (United States)

    Y Neira-Guio, A.; Gómez Cuaspud, J. A.; López, E. Vera; Pineda Triana, Y.

    2017-12-01

    This paper describes the synthesis and characterization of two spinel and olivine-type multicomponent oxides based on LiMO2 and LiM2O4 systems (M=Co and Mn), which represent the current state of the art in the development of cathodes for Li-ion batteries. A simple combustion synthesis process was employed to obtain the nanometric oxides in powder form (crystal sizes around 5-8nm), with a number of improved surface characteristics. The characterization by X-Ray Diffraction (XRD), Scanning and Transmission Electron Microscopy (SEM, TEM) and X-Ray Fluorescence (XRF), allowed to evaluate the morphology and the stoichiometric compositions of solids, obtaining a concordant pure crystalline phase of LiCoO2 and LiMn2O4 oxides identified in a rhombohedral and cubic phase with punctual group R-3m (1 6 6) and Fm-3m (2 2 5) respectively. The electrical characterization of materials developed by impedance spectroscopy solid state, allowed to determine a p-type semiconducting behaviour with conductivity values of 6.2×10-3 and 2.7×10-7 S for LiCoO2 and LiMn2O4 systems, consistent with the state of the art for such materials.

  7. Nothing a hot bath won't cure: infection rates of amphibian chytrid fungus correlate negatively with water temperature under natural field settings.

    Directory of Open Access Journals (Sweden)

    Matthew J Forrest

    Full Text Available Dramatic declines and extinctions of amphibian populations throughout the world have been associated with chytridiomycosis, an infectious disease caused by the pathogenic chytrid fungus Batrachochytrium dendrobatidis (Bd. Previous studies indicated that Bd prevalence correlates with cooler temperatures in the field, and laboratory experiments have demonstrated that Bd ceases growth at temperatures above 28°C. Here we investigate how small-scale variations in water temperature correlate with Bd prevalence in the wild. We sampled 221 amphibians, including 201 lowland leopard frogs (Rana [Lithobates] yavapaiensis, from 12 sites in Arizona, USA, and tested them for Bd. Amphibians were encountered in microhabitats that exhibited a wide range of water temperatures (10-50°C, including several geothermal water sources. There was a strong inverse correlation between the water temperature in which lowland leopard frogs were captured and Bd prevalence, even after taking into account the influence of year, season, and host size. In locations where Bd was known to be present, the prevalence of Bd infections dropped from 75-100% in water 30°C. A strong inverse correlation between Bd infection status and water temperature was also observed within sites. Our findings suggest that microhabitats where water temperatures exceed 30°C provide lowland leopard frogs with significant protection from Bd, which could have important implications for disease dynamics, as well as management applications.There must be quite a few things a hot bath won't cure, but I don't know many of them--Sylvia Plath, "The Bell Jar" (1963.

  8. Nothing a hot bath won't cure: infection rates of amphibian chytrid fungus correlate negatively with water temperature under natural field settings.

    Science.gov (United States)

    Forrest, Matthew J; Schlaepfer, Martin A

    2011-01-01

    Dramatic declines and extinctions of amphibian populations throughout the world have been associated with chytridiomycosis, an infectious disease caused by the pathogenic chytrid fungus Batrachochytrium dendrobatidis (Bd). Previous studies indicated that Bd prevalence correlates with cooler temperatures in the field, and laboratory experiments have demonstrated that Bd ceases growth at temperatures above 28°C. Here we investigate how small-scale variations in water temperature correlate with Bd prevalence in the wild. We sampled 221 amphibians, including 201 lowland leopard frogs (Rana [Lithobates] yavapaiensis), from 12 sites in Arizona, USA, and tested them for Bd. Amphibians were encountered in microhabitats that exhibited a wide range of water temperatures (10-50°C), including several geothermal water sources. There was a strong inverse correlation between the water temperature in which lowland leopard frogs were captured and Bd prevalence, even after taking into account the influence of year, season, and host size. In locations where Bd was known to be present, the prevalence of Bd infections dropped from 75-100% in water 30°C. A strong inverse correlation between Bd infection status and water temperature was also observed within sites. Our findings suggest that microhabitats where water temperatures exceed 30°C provide lowland leopard frogs with significant protection from Bd, which could have important implications for disease dynamics, as well as management applications.There must be quite a few things a hot bath won't cure, but I don't know many of them--Sylvia Plath, "The Bell Jar" (1963).

  9. Capacidad de uso de las tierras en la microcuenca El Limón, complejo de cuencas Sabana Yegua, República Dominicana Land use capacity in the mini watershed El Limón, Sabana Yegua Watershed Complex, Dominican Republic

    Directory of Open Access Journals (Sweden)

    Maldané Cuello Espinoza

    2013-03-01

    Full Text Available Este estudio aborda el análisis biofísico de las tierras en la microcuenca El Limón, en el complejo de Cuencas Altas de Sabana Yegua en República Dominicana. El objetivo del ensayo fue determinar la capacidad de uso de las tierras considerando las limitaciones del suelo, el clima y la geomorfología que presenta. Se propone una serie de prácticas de manejo como opciones para reducir la erosión, mejorar el suelo y acondicionar los caminos, lo que permitiría mantener condiciones favorables para el manejo racional del sistema. De esa forma, con este objetivo se establecen y se integran por primera vez en una cuenca del país varios elementos limitantes para con su identificación proponer prácticas apropiadas que controlen el problema de degradación acelerada que experimenta el área bajo estudio. Para ello, se determinaron parámetros fundamentales, los cuales abarcan factores de erosión, suelo, drenaje y clima, en función de lo que establece la metodología MAG/FAO/UNED (1996, la cual se usa en Costa Rica para determinar la capacidad de uso de las tierras y ha sido adaptada al área objeto de este estudio. Esta metodología integra clases de tierras que van desde la I hasta la VIII según la frecuencia y grado de las limitantes que se identifican. Para su aplicación en la microcuenca El Limón, se han incluido otros parámetros físicos que no contemplan dicha metodología, tales como la densidad aparente del suelo y los parámetros climáticos de lluvia y temperatura, estos últimos con el fin de establecer la zona de vida del área. Se pudo determinar que las clases de tierras en la microcuenca El Limón van desde la III hasta la VIII, las cuales son aptas para protección, sistemas forestales y agroforestería. De igual manera, se estableció que las mayores limitantes que se presentan son las concernientes a la erosión y al drenaje del suelo. Para frenar y corregir los efectos de estas limitantes, las prácticas de manejo

  10. Densidades de plantio e doses de biofertilizante na produção de capim-limão Density and biofertilizer levels for lemon grass production

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    Arie F Blank

    2007-09-01

    Full Text Available O objetivo do trabalho foi avaliar o efeito de densidades de plantio e doses de biofertilizante comercial na produção de capim-limão (Cymbopogon citratus (D.C. Stapf. O experimento foi implantado em parcelas subdivididas com três repetições, colocando-se nas parcelas as densidades de plantio (33.333, 49.382, 55.555 e 111.111 plantas ha-1 e nas subparcelas as doses de biofertilizante (0; 20; 40 e 60 t ha-1. Foram realizadas nove colheitas em intervalos de 42 dias. Avaliou-se a sobrevivência, a altura de planta, o número de perfilhos por touceira, a massa seca por touceira e da parte aérea, o teor e o rendimento de óleo essencial. O teor de óleo essencial não foi influenciado pelas densidades de plantio e doses de biofertilizante. A densidade crescente resultou em regressões lineares crescentes para o rendimento de óleo essencial e a massa seca da parte aérea e em uma regressão linear decrescente para a massa seca por touceira. A dose de biofertilizante resultou em regressões lineares crescentes para o rendimento de óleo essencial e a massa seca por touceira e da parte aérea. A densidade de 111.111 plantas ha-1 (0,30 x 0,30 m e a dose de biofertilizante de 60 t ha-1 no primeiro ano de cultivo poderão ser recomendados para produção do capim-limão.The aim of this work was to evaluate the plant density and biofertilizer levels on lemon grass (Cymbopogom citratus (D.C. Stapf. The experiment was installed in split plot design with three replications, having plant density as plots (33,333; 49,382; 55,555 and 111,111 plants ha-1 and biofertilizer doses as sub plots (0; 20; 40; 60 t ha-1 year-1. Nine cuttings were realized using an interval of 42 days between cuttings. We evaluated survival, plant height, number of tillers per plant, dry weight per plant and of biomass yield, essential oil content and yield. The essential oil content was not influenced by the plant densities and biofertilizer doses. The crescent density resulted in

  11. [Intestinal parasites in white-faced capuchin monkeys Cebus capucinus (Primates: Cebidae) inhabiting a protected area in the Limón province of Northeastern Costa Rica].

    Science.gov (United States)

    Chinchilla, Misael; Urbani, Bernardo; Valerio, Idalia; Vanegas, Juan Carlos

    2010-12-01

    Deforestation of tropical forests is threatening monkey biodiversity and their health status, dependent of an ecologically undisturbed area. To asses this relationship, we analyzed parasite occurrence in their intestines. The study was conducted at the Estación Biológica La Suerte (EBLS), Limón, Costa Rica. The group of white-faced capuchin monkeys (Cebus capucinus) was observed between March and December of 2006. A total of 75 feces samples were obtained. Once a sample was collected, the eaten plant type was identified to family and species level, and feces were processed in the laboratory to determine parasite incidence. Results showed that Moraceae was the most represented family in the samples. Among parasites, Strongyloides spp. and Acanthocephala were the most common. Positive prevalence of parasites was found similar and independent of sex and age of capuchin individuals. Microsporids were mainly reported in feces associated with Piperaceae. A low presence of these parasites was found in samples associated with Myrtaceae, with possible anti-parasite active components. The occurrence of parasites was relatively high in EBLS, when compared to other regions in Costa Rica. The higher occurrence of parasites observed in capuchins at EBLS may be due to the fact that this rain forest is surrounded by areas affected by human activities. We suggest the promotion of research in neotropical primates parasitology, for a better comprehension of the parasite-host relationship, and in a long term, being able to understand the ecosystems where they coexist, and consequently, preserve the biodiversity of the whole region.

  12. The LIM homeodomain transcription factor LHX6: a transcriptional repressor that interacts with pituitary homeobox 2 (PITX2) to regulate odontogenesis.

    Science.gov (United States)

    Zhang, Zichao; Gutierrez, Diana; Li, Xiao; Bidlack, Felicitas; Cao, Huojun; Wang, Jianbo; Andrade, Kelsey; Margolis, Henry C; Amendt, Brad A

    2013-01-25

    LHX6 is a LIM-homeobox transcription factor expressed during embryogenesis; however, the molecular mechanisms regulating LHX6 transcriptional activities are unknown. LHX6 and the PITX2 homeodomain transcription factor have overlapping expression patterns during tooth and craniofacial development, and in this report, we demonstrate new transcriptional mechanisms for these factors. PITX2 and LHX6 are co-expressed in the oral and dental epithelium and epithelial cell lines. Lhx6 expression is increased in Pitx2c transgenic mice and decreased in Pitx2 null mice. PITX2 activates endogenous Lhx6 expression and the Lhx6 promoter, whereas LHX6 represses its promoter activity. Chromatin immunoprecipitation experiments reveal endogenous PITX2 binding to the Lhx6 promoter. LHX6 directly interacts with PITX2 to inhibit PITX2 transcriptional activities and activation of multiple promoters. Bimolecular fluorescence complementation assays reveal an LHX6·PITX2 nuclear interaction in living cells. LHX6 has a dominant repressive effect on the PITX2 synergistic activation with LEF-1 and β-catenin co-factors. Thus, LHX6 acts as a transcriptional repressor and represses the expression of several genes involved in odontogenesis. We have identified specific defects in incisor, molar, mandible, bone, and root development and late stage enamel formation in Lhx6 null mice. Amelogenin and ameloblastin expression is reduced and/or delayed in the Lhx6 null mice, potentially resulting from defects in dentin deposition and ameloblast differentiation. Our results demonstrate that LHX6 regulates cell proliferation in the cervical loop and promotes cell differentiation in the anterior region of the incisor. We demonstrate new molecular mechanisms for LHX6 and an interaction with PITX2 for normal craniofacial and tooth development.

  13. Nuclear localization of lymphocyte-specific protein tyrosine kinase (Lck) and its role in regulating LIM domain only 2 (Lmo2) gene

    Energy Technology Data Exchange (ETDEWEB)

    Venkitachalam, Srividya; Chueh, Fu-Yu [Department of Microbiology and Immunology, H. M. Bligh Cancer Research Laboratories, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL 60064 (United States); Yu, Chao-Lan, E-mail: chaolan.yu@rosalindfranklin.edu [Department of Microbiology and Immunology, H. M. Bligh Cancer Research Laboratories, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL 60064 (United States)

    2012-01-20

    Highlights: Black-Right-Pointing-Pointer Lmo2 expression is elevated in Lck-transformed cells. Black-Right-Pointing-Pointer Both endogenous and exogenous Lck localize in the nucleus. Black-Right-Pointing-Pointer Nuclear Lck is active in Lck-transformed cells. Black-Right-Pointing-Pointer Lck binds to the promoter region of Lmo2 gene in vivo. Black-Right-Pointing-Pointer In contrast to JAK2, Lck does not increase histone H3 phosphorylation on Tyr 41. -- Abstract: LIM domain only protein 2 (Lmo2) is a transcription factor that plays a critical role in the development of T-acute lymphoblastic leukemia (T-ALL). A previous report established a link between Lmo2 expression and the nuclear presence of oncogenic Janus kinase 2 (JAK2), a non-receptor protein tyrosine kinase. The oncogenic JAK2 kinase phosphorylates histone H3 on Tyr 41 that leads to the relief of Lmo2 promoter repression and subsequent gene expression. Similar to JAK2, constitutive activation of lymphocyte-specific protein tyrosine kinase (Lck) has been implicated in lymphoid malignancies. However, it is not known whether oncogenic Lck regulates Lmo2 expression through a similar mechanism. We show here that Lmo2 expression is significantly elevated in T cell leukemia LSTRA overexpressing active Lck kinase and in HEK 293 cells expressing oncogenic Y505FLck kinase. Nuclear localization of active Lck kinase was confirmed in both Lck-transformed cells by subcellular fractionation and immunofluorescence microscopy. More importantly, in contrast to oncogenic JAK2, oncogenic Lck kinase does not result in significant increase in histone H3 phosphorylation on Tyr 41. Instead, chromatin immunoprecipitation experiment shows that oncogenic Y505FLck kinase binds to the Lmo2 promoter in vivo. This result raises the possibility that oncogenic Lck may activate Lmo2 promoter through direct interaction.

  14. Avaliação genética de seleções e híbridos de limões cravo, volkameriano e rugoso como porta-enxertos para laranjeiras Valência na presença da morte súbita dos citros

    Directory of Open Access Journals (Sweden)

    Jorgino Pompeu Junior

    2013-03-01

    Full Text Available Este estudo teve como objetivo realizar a avaliação genética da produção de frutos, eficiência produtiva e altura de laranjeiras Valência (Citrus sinensis enxertadas em seleções e híbridos dos limões Cravo (C. limonia, Volkameriano (C. volkameriana e Rugoso (C. jambhiri, em área endêmica para morte súbita dos citros (MSC. Foram avaliados 36 genótipos desses porta-enxertos, representados por cinco plantas cada, avaliados em cinco safras, do terceiro ao sétimo ano após o plantio. Sete dos genótipos avaliados apresentaram plantas com sintomas de MSC até o sétimo ano: Rangpur Otaheite orange 12901 (859, Rangpur Red Lime D.33.30 (866, Limão-Cravo EEL (871, Rangpur Borneo red (874, Citrus kokhai (1649, Limão-Rugoso 58329 (1655 e Limão- Cravo x Swingle B (1695. Para os genótipos que não manifestaram sintomas da doença, foram estimados parâmetros genéticos e fenotípicos e realizada a predição de valores genéticos dos indivíduos, visando à seleção e ao melhoramento genético para as características citadas, empregando-se o método REML/BLUP (máxima verossimilhança restrita/melhor predição linear não viciada. A análise de produção de frutos de cinco safras mostrou acurácia seletiva de 84,59%, tornando-se desnecessária a avaliação de maior número de safras. A seleção dos sete melhores genótipos proporcionou ganhos genéticos de 11,5% na produção de frutos, enquanto a do melhor genótipo conferiu ganho genético de 16,3%. As maiores médias genéticas preditas (>70,0 kg.pl-1 para produção de frutos foram obtidas pelos genótipos Limão-Cravo- Ipanema (1522, Santa- Bárbara-Red- Lime (884, Limão- Cravo- Limeira (863, Limão- Cravo- Taquaritinga (869, Limão- Rugoso- do -Cabo (1643, Rangpur- Rose Lime (868 e Limão- Cravo- da- Califórnia (1467. Já a acurácia seletiva da eficiência produtiva, para quatro colheitas, foi 77,4%. Para este caráter, as maiores médias genéticas (>8,0 kg.m-3 foram dos

  15. La comunidad de Mata de Limón, Pacífico central de Costa Rica y la extracción de colonchos Callichirus seilacheri (Bott, 1955 (Decapoda: Axiidea: Callianassidae

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    Patricio Hernáez

    2015-07-01

    Full Text Available En el presente estudio, se realizaron visitas mensuales a la comunidad de Mata de Limón (diciembre 2011 a noviembre 2012 localizada en el Pacífico central de Costa Rica para evaluar una serie de aspectos pesqueros relativos a la extracción del camarón excavador Callichirus seilacheri. Esta especie llamada comúnmente coloncho por los recolectores locales es intensamente capturada y comercializada como carnada para la pesca deportiva en la costa del Pacífico de América Central. Los resultados indican que el esfuerzo pesquero varió entre 4 y 14 recolectores día-1 con un alto porcentaje de ellos procedentes de la misma comunidad (70-100%. Las capturas diarias variaron entre 76 y 1120 camarones dependiendo principalmente del esfuerzo pesquero realizado por recolectores locales (R² = 0,88. La densidad de colonchos fue de 1,2 ± 0,88 ind m-2 y su abundancia total en el Estero de Mata de Limón fue estimada en 49.607 ± 3.638 individuos. Las hembras ovígeras estuvieron presentes de mayo a noviembre, con un máximo en septiembre. Los resultados de este estudio indican que la población de colonchos puede estar en grave riesgo de sobre-explotación si las capturas diarias superan los 800 individuos. Por ello, se recomienda la implementación de una veda total durante el pico de reproducción de C. seilacheri de manera de que este recurso local sea protegido y conservado para su uso sostenible. Se sugiere además la implementación de un plan de manejo entre la comunidad de Mata de Limón y el Instituto Costarricense de Pesca y Acuicultura (INCOPESCA de manera de optimizar y legalizar la extracción de este recurso.

  16. Aplicación de modelos matemáticos al proceso de secado asistido por infrarrojos de descartes de limón (Citrus limon (L.) Burm. F. Cv. Genova)

    OpenAIRE

    Luis Puente-Díaz; Eric Echegaray-Pacheco; Eduardo Castro- Montero; Karina Di Scala

    2013-01-01

    Los desechos agroindustriales son uno de los principales problemas ambientales a nivel mundial. Debido a las altas exigencias de calidad, la comercialización de limones de exportación genera grandes cantidades de desechos. Los descartes de limón contienen fibra, pectina, potasio, calcio y vitamina C. Por lo tanto, es importante desarrollar alternativas de procesamiento de estos sub-productos para agregarles valor y aumentar su vida útil. El objetivo de la presente investigación fue la aplicac...

  17. Aplicación de modelos matemáticos al proceso de secado asistido por infrarrojos de descartes de limón (citrus limon (l.) burm. f. cv. genova)

    OpenAIRE

    PUENTE-DÍAZ, LUIS; ECHEGARAY- PACHECO, ERIC; CASTRO- MONTERO, EDUARDO; Di Scala,Karina

    2013-01-01

    Los desechos agroindustriales son uno de los principales problemas ambientales a nivel mundial. Debido a las altas exigencias de calidad, la comercialización de limones de exportación genera grandes cantidades de desechos. Los descartes de limón contienen fi bra, pectina, potasio, calcio y vitamina C. Por lo tanto, es importante desarrollar alternativas de procesamiento de estos sub-productos para agregarles valor y aumentar su vida útil. El objetivo de la presente investigación fue la aplica...

  18. Proceso de sensibilización y empoderamiento local frente al uso sostenible del suelo en la microcuenca El Limón, cuencas altas Sabana Yegua, República Dominicana

    OpenAIRE

    Maldané Cuello Espinosa

    2011-01-01

    Este artículo trata el desarrollo de un proceso de sensibilización y empoderamiento por parte de los productores y productoras agrícolas de la microcuenca El Limón, dentro del complejo de cuencas que alimentan a la presa Sabana Yegua, en República Dominicana. La metodología implementada en el proceso se basa en un enfoque participativo local, que a su vez está basado en el modelo de Acción Ambiental Positiva (AAP), el cual incluye los elementos de habilidades y procedimientos, conceptos, empo...

  19. “Competitividad de la Agroindustria de Exportación de Lima y Limón: Caso Comparado de Michoacán – Colima, en México y Murcia, en España”

    OpenAIRE

    Franco Estrada, Nallely Monserrat

    2012-01-01

    La competitividad permite identificar las claves del desarrollo económico de sectores específicos, incluso de los países. Los nuevos retos competitivos exigen tener sectores claves y en crecimiento para lograr posicionarse en el comercio internacional. La finalidad de la presente investigación es contribuir a la formulación de estrategias para mejorar la competitividad de las empresas exportadoras de la cadena agroalimentaria de lima y limón en México. Para ello se plantea como...

  20. Role of hepatitis B virus X protein in regulating LIM and SH3 protein 1 (LASP-1 expression to mediate proliferation and migration of hepatoma cells

    Directory of Open Access Journals (Sweden)

    Tang Renxian

    2012-08-01

    Full Text Available Abstract Background Hepatitis B virus X protein (HBx has been shown to be responsible for the development of hepatocellular carcinoma (HCC caused by Hepatitis B virus infection. However, its potential effect on the progression of hepatocellular carcinoma remains yet unclear. LIM and SH3 protein 1 (LASP-1, a focal adhesion protein, is expressed in an up-regulation manner in the HCC tissues. LASP-1 plays an important role in the regulation of proliferation and migration of HCC. In this study, we investigated the effect of LASP-1 involved in HBx-related tumor progression. Methods LASP-1 levels in the HBx stable transfected HepG2 and Huh-7 cells were detected by RT-PCR and western blot analysis. The cellular localization of LASP-1 was assessed by immunofluorescence analysis. The activity of phosphatidylinositol 3-kinase (PI3-K pathway was demonstrated by western blot assay. The HBx-expressing cells were transfected with specific small interference RNA (siRNA against LASP-1. The proliferation and migration ability of cells were evaluated by cell viability assay and plate clone formation assay. The migration ability of cells was detected by transwell assay and wound healing assay. Results RT-PCR and western blot analysis indicated the expression of LASP-1 was increased in the stable HBx-expressing cells compared with the control cells. Immunofluorescence study revealed that the distributions of LASP-1 in HepG2-HBX cells were mainly in pseudopods and the cytoplasm while they were mainly localized in the cytoplasm of HepG2-Mock cells. The cellular localizations of LASP-1 in Huh-7-HBX cells were in the perinuclear fractions while they were mainly localized in the cytoplasm of Huh-7-Mock cells. The upregulation of LASP-1 was inhibited after treatment with LY294002, PI3-K pathway inhibitor. Overexpression of LASP-1 in the stable HBx-expressing cells enhanced the proliferation and migration ability of hepatocellular cells. siRNA-mediated LASP-1 knowdown in

  1. Assessment of the sea-ice carbon pump: Insights from a three-dimensional ocean-sea-ice biogeochemical model (NEMO-LIM-PISCES

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    Sébastien Moreau

    2016-08-01

    Full Text Available Abstract The role of sea ice in the carbon cycle is minimally represented in current Earth System Models (ESMs. Among potentially important flaws, mentioned by several authors and generally overlooked during ESM design, is the link between sea-ice growth and melt and oceanic dissolved inorganic carbon (DIC and total alkalinity (TA. Here we investigate whether this link is indeed an important feature of the marine carbon cycle misrepresented in ESMs. We use an ocean general circulation model (NEMO-LIM-PISCES with sea-ice and marine carbon cycle components, forced by atmospheric reanalyses, adding a first-order representation of DIC and TA storage and release in/from sea ice. Our results suggest that DIC rejection during sea-ice growth releases several hundred Tg C yr−1 to the surface ocean, of which < 2% is exported to depth, leading to a notable but weak redistribution of DIC towards deep polar basins. Active carbon processes (mainly CaCO3 precipitation but also ice-atmosphere CO2 fluxes and net community production increasing the TA/DIC ratio in sea-ice modified ocean-atmosphere CO2 fluxes by a few Tg C yr−1 in the sea-ice zone, with specific hemispheric effects: DIC content of the Arctic basin decreased but DIC content of the Southern Ocean increased. For the global ocean, DIC content increased by 4 Tg C yr−1 or 2 Pg C after 500 years of model run. The simulated numbers are generally small compared to the present-day global ocean annual CO2 sink (2.6 ± 0.5 Pg C yr−1. However, sea-ice carbon processes seem important at regional scales as they act significantly on DIC redistribution within and outside polar basins. The efficiency of carbon export to depth depends on the representation of surface-subsurface exchanges and their relationship with sea ice, and could differ substantially if a higher resolution or different ocean model were used.

  2. Aplicación de modelos matemáticos al proceso de secado asistido por infrarrojos de descartes de limón (Citrus limon (L. Burm. F. Cv. Genova

    Directory of Open Access Journals (Sweden)

    Luis Puente-Díaz

    2013-01-01

    Full Text Available Los desechos agroindustriales son uno de los principales problemas ambientales a nivel mundial. Debido a las altas exigencias de calidad, la comercialización de limones de exportación genera grandes cantidades de desechos. Los descartes de limón contienen fibra, pectina, potasio, calcio y vitamina C. Por lo tanto, es importante desarrollar alternativas de procesamiento de estos sub-productos para agregarles valor y aumentar su vida útil. El objetivo de la presente investigación fue la aplicación del secado asistido por infrarrojos, como tecnología emergente, para estudiar el efecto de la temperatura de proceso sobre las cinéticas de secado de descartes de limón a 30, 40 y 50°C. Se utilizaron seis modelos matemáticos de capa fina encontrados en literatura para representar la cinética experimental. Basándose en análisis estadístico, el modelo Logarítmico presentó el mejor ajuste. Los valores de la difusividad efectiva del agua se estimaron en el rango de 9.45× 10-10 – 3.71× 10-9 m/s2. El valor de la energía de activación fue 55.90 kJ/mol.

  3. Morte súbita dos citros: suscetibilidade de seleções de limão-cravo e uso de interenxertos Citrus sudden death: susceptibility of rangpur lime selections and the use of interstocks

    Directory of Open Access Journals (Sweden)

    Jorgino Pompeu Junior

    2008-12-01

    Full Text Available A morte súbita dos citros é uma doença que afeta cultivares de laranjas e tangerinas enxertadas nos limões-Cravo e Volkameriano. Ela foi observada em plantas com dois a seis anos de idade que, após mostrarem sintomas gerais de declínio, entraram em colapso e morreram. A retirada da casca dos porta-enxertos suscetíveis revela o amarelecimento na região cambial, sendo esse o sintoma-diagnóstico da doença e que precede os sintomas da copa. As plantas enxertadas nas tangerinas Cleópatra e Sunki, no trifoliata e no citrumelo Swingle, não mostram sintomas da doença. A transmissão por borbulha e a evolução espacial sugerem que a morte súbita dos citros seja causada por patógeno transmitido por vetor alado. Com o objetivo de selecionar porta-enxertos tolerantes à doença, laranjeiras Valência enxertadas em 254 porta-enxertos foram plantadas em maio de 2003 e 2004 em solos onde foram erradicados pomares afetados pela morte súbita dos citros e próximos a pomares afetados pela doença. Em novembro de 2006, o sintoma-diagnóstico da doença estava presente em dez seleções de limão-Cravo: Santa Barbara red lime, Borneo red lime, Limão-Cravo Taquaritinga, Rangpur India C-26-1, Rangpur rose lemon, Rangpur Kusaie lime, Rangpur red lime D-33-40, Rangpur Egyptian lime, Rangpur lemon India e Japanshe citroen. A presença de interenxerto de trifoliata ou de tangerina Cleópatra, entre o limão-Cravo e a laranja Valência, não impediu a manifestação da doença.Citrus sudden death (CSD or morte súbita dos citros affects sweet orange cultivars and some mandarin trees grafted on Rangpur lime and Volkamer lemon rootstocks. The disease was observed in trees with ages ranging from two to six years; after showing general decline symptoms, the affected trees suddenly collapse and die. Trees on Cleopatra and Sunki mandarins, 'Swingle' citrumelo and trifoliate orange showed no symptoms of CSD. Cambial yellowing in the rootstock can be observed

  4. Changes in the structure and pigmentation of the eyes of honeybee (Apis mellifera L. queens with the "limão" mutation

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    José Chaud-Netto

    2000-03-01

    Full Text Available This study describes the ultrastructural differences between the compound eyes of ch li/ch li and Ch/ch li honeybee queens. Heterozygous "limão" bees had an almost normal ultrastructural organization of the ommatidia, but there were some alterations, including small vacuoles in the crystalline cones and a loss of pigment by primary pigmentary cells. In homozygous bees many ommatidia had very deformed crystalline cones and there were some bipartite rhabdoma. There was a reduction in the amount of pigment in the primary and secondary pigmentary cells and receptor cells (retinulae of mutant eyes. However, the eyes of both heterozygous and homozygous queens had the same type of pigment granules. Certain membrane-limited structures containing pigment granules and electron-dense material appeared to be of lysosomal nature. Since these structures occurred in the retinular cells of mutant eyes, they were considered to be multivesicular bodies responsible for the reduction in rhabdom volume in the presence of light, as a type of adaptation to brightness. The reduction of pigment in the pigmentary and retinular cells and the morphological changes seen in the rhabdom of the ommatidia may originate visual deficiencies, which could explain the behavioral modifications reported for Apis mellifera queens with mutant eye color.Este estudo descreve as diferenças ultra-estruturais entre os olhos compostos de rainhas de abelhas de genótipo ch li/ch li e Ch/ch li. Foram registradas diferenças na organização do omatídeo e na pigmentação geral dos dois tipos de olhos. As abelhas heterozigotas apresentaram organização ultra-estrutural dos omatídeos praticamente normal. Contudo, foram observadas algumas alterações nos cones cristalinos, particularmente a presença de pequenos vacúolos nas células dos cones e perda de pigmento pelas células pigmentares primárias. Nas abelhas homozigotas foram encontrados vários omatídeos com cones cristalinos muito

  5. LIMS for Lasers 2015 for achieving long-term accuracy and precision of δ2H, δ17O, and δ18O of waters using laser absorption spectrometry

    Science.gov (United States)

    Coplen, Tyler B.; Wassenaar, Leonard I

    2015-01-01

    RationaleAlthough laser absorption spectrometry (LAS) instrumentation is easy to use, its incorporation into laboratory operations is not easy, owing to extensive offline manipulation of comma-separated-values files for outlier detection, between-sample memory correction, nonlinearity (δ-variation with water amount) correction, drift correction, normalization to VSMOW-SLAP scales, and difficulty in performing long-term QA/QC audits.MethodsA Microsoft Access relational-database application, LIMS (Laboratory Information Management System) for Lasers 2015, was developed. It automates LAS data corrections and manages clients, projects, samples, instrument-sample lists, and triple-isotope (δ17O, δ18O, and δ2H values) instrumental data for liquid-water samples. It enables users to (1) graphically evaluate sample injections for variable water yields and high isotope-delta variance; (2) correct for between-sample carryover, instrumental drift, and δ nonlinearity; and (3) normalize final results to VSMOW-SLAP scales.ResultsCost-free LIMS for Lasers 2015 enables users to obtain improved δ17O, δ18O, and δ2H values with liquid-water LAS instruments, even those with under-performing syringes. For example, LAS δ2HVSMOW measurements of USGS50 Lake Kyoga (Uganda) water using an under-performing syringe having ±10 % variation in water concentration gave +31.7 ± 1.6 ‰ (2-σ standard deviation), compared with the reference value of +32.8 ± 0.4 ‰, after correction for variation in δ value with water concentration, between-sample memory, and normalization to the VSMOW-SLAP scale.ConclusionsLIMS for Lasers 2015 enables users to create systematic, well-founded instrument templates, import δ2H, δ17O, and δ18O results, evaluate performance with automatic graphical plots, correct for δ nonlinearity due to variable water concentration, correct for between-sample memory, adjust for drift, perform VSMOW-SLAP normalization, and perform long-term QA/QC audits

  6. Comparación del "Tabog" (Swinglea glutinosa Merr con el limón "rugoso" (Citrus jambhiri Swingle y la mandarina "Cleopatra" (C. reticulata Swingle como porta-injerto para la lima acida ''Tahiti" (C. aurantifolia Swingle

    Directory of Open Access Journals (Sweden)

    Restrepo C. Orlando

    1987-09-01

    Full Text Available At the C.N.I.-I.C.A. Palmira, fruit trees program the influence of "Tabog" Swinglea glutinosa was evaluated as rootstock for acid lime "Tahiti" Citrus aurantifolia, taking into account the following aspects: development and productivility of the trees quality and growth of fruits, demands of nutriments, and resistance or susceptibility to pest and disease; comparing its behavior with the commercial rootstocks rough, lemon C. jambhiri and mandarina, "Cleopatra" C. reticulata.En el C.N.l. Palmira del Instituto Colombiano Agropecuario (lCA, se evaluó la influencia del "Tabog" Swinglea glutinosa como porta-injerto para la lima "Tahiti " Citrus aurantifolia, teniendo en cuenta los siguientes aspectos: desarrollo y productividad del árbol, calidad y desarrollo de los frutos, exigencias de nutrimentos, resistencia o susceptibilidad a plagas y enfermedades; comparando su comportamiento con los porta-injertos comerciales limón "Rugoso" C. jambhiri y la mandarina "Cleopatra " C. reticulata.

  7. Estabilidade físico-química e sensorial do suco de limão Tahiti natural e adoçado, congelado Sensory and physicochemical stability of frozen Tahiti lime juice, natural and sweetened

    Directory of Open Access Journals (Sweden)

    Mayka R. PEDRÃO

    1999-05-01

    Full Text Available Suco de limão Tahiti adoçado com 60% de sacarose (p:p e puro foram congelados e armazenados por 60 dias. Análise de variância, comparação de médias e regressão foram usadas para avaliar o efeito da adição de sacarose e tempo de armazenamento nas propriedades físico-químicas e sensoriais dos dois tipos de sucos. Sessenta por cento de sacarose foi escolhido pois simples diluição produziu limonada com boa aceitabilidade. O suco natural foi adoçado e diluído na mesma proporção que o suco adoçado antes das análises. A concentração de sólidos solúveis, acidez titulável e ácido ascórbico, e pH do suco não foram afetados pelo tempo de armazenamento. Houve escurecimento do suco durante o armazenamento, não detectado na análise sensorial, mas determinado pelo método espectrofotométrico. Atributos sensoriais de sabor e odor de limão passado e percepção de doçura foram afetados por tempo de armazenamento.Tahiti lime juice sweetened with 60% sucrose (w:w and natural was frozen and stored for 60 days. Analysis of variance, comparison of means and regression analysis were used to evaluate the effect of sucrose addition and time of storage on physicochemical and sensory characteristics of the juices. Sixty percent sucrose was added because simple dilution of the sweetened juice produced limonade with high acceptability. The juice stored without sugar was sweetened and diluted in the same proportion of the sweetened one before analysis. Concentration of soluble solids, total acidity and ascorbic acid, and pH of the juice were not affected by storage time. Sensory analysis did not detect the darkening that occurred during storage, which could be determined by spectrophotametry. Sensory attributes of aroma and flavor of aged lime juice, as well as sweetness perception were affected by storage time.

  8. Human T-Cell Leukemia Virus Type I-Mediated Repression of PDZ-LIM Domain-Containing Protein 2 Involves DNA Methylation But Independent of the Viral Oncoprotein Tax

    Directory of Open Access Journals (Sweden)

    Pengrong Yan

    2009-10-01

    Full Text Available Human T-cell leukemia virus type I (HTLV-I is the etiological agent of adult T-cell leukemia (ATL. Our recent studies have shown that one important mechanism of HTLV-I-Mediated tumorigenesis is through PDZ-LIM domain-containing protein 2 (PDLIM2 repression, although the involved mechanism remains unknown. Here, we further report that HTLV-I-Mediated PDLIM2 repression was a pathophysiological event and the PDLIM2 repression involved DNA methylation. Whereas DNA methyltransferases 1 and 3b but not 3a were upregulated in HTLV-I-transformed T cells, the hypomethylating agent 5-aza-2′-deoxycytidine (5-aza-dC restored PDLIM2 expression and induced death of these malignant cells. Notably, the PDLIM2 repression was independent of the viral regulatory protein Tax because neither short-term induction nor long-term stable expression of Tax could downregulate PDLIM2 expression. These studies provide important insights into PDLIM2 regulation, HTLV-I leukemogenicity, long latency, and cancer health disparities. Given the efficient antitumor activity with no obvious toxicity of 5-aza-dC, these studies also suggest potential therapeutic strategies for ATL.

  9. Sea-ice evaluation of NEMO-Nordic 1.0: a NEMO-LIM3.6-based ocean-sea-ice model setup for the North Sea and Baltic Sea

    Science.gov (United States)

    Pemberton, Per; Löptien, Ulrike; Hordoir, Robinson; Höglund, Anders; Schimanke, Semjon; Axell, Lars; Haapala, Jari

    2017-08-01

    The Baltic Sea is a seasonally ice-covered marginal sea in northern Europe with intense wintertime ship traffic and a sensitive ecosystem. Understanding and modeling the evolution of the sea-ice pack is important for climate effect studies and forecasting purposes. Here we present and evaluate the sea-ice component of a new NEMO-LIM3.6-based ocean-sea-ice setup for the North Sea and Baltic Sea region (NEMO-Nordic). The setup includes a new depth-based fast-ice parametrization for the Baltic Sea. The evaluation focuses on long-term statistics, from a 45-year long hindcast, although short-term daily performance is also briefly evaluated. We show that NEMO-Nordic is well suited for simulating the mean sea-ice extent, concentration, and thickness as compared to the best available observational data set. The variability of the annual maximum Baltic Sea ice extent is well in line with the observations, but the 1961-2006 trend is underestimated. Capturing the correct ice thickness distribution is more challenging. Based on the simulated ice thickness distribution we estimate the undeformed and deformed ice thickness and concentration in the Baltic Sea, which compares reasonably well with observations.

  10. Sea-ice evaluation of NEMO-Nordic 1.0: a NEMO–LIM3.6-based ocean–sea-ice model setup for the North Sea and Baltic Sea

    Directory of Open Access Journals (Sweden)

    P. Pemberton

    2017-08-01

    Full Text Available The Baltic Sea is a seasonally ice-covered marginal sea in northern Europe with intense wintertime ship traffic and a sensitive ecosystem. Understanding and modeling the evolution of the sea-ice pack is important for climate effect studies and forecasting purposes. Here we present and evaluate the sea-ice component of a new NEMO–LIM3.6-based ocean–sea-ice setup for the North Sea and Baltic Sea region (NEMO-Nordic. The setup includes a new depth-based fast-ice parametrization for the Baltic Sea. The evaluation focuses on long-term statistics, from a 45-year long hindcast, although short-term daily performance is also briefly evaluated. We show that NEMO-Nordic is well suited for simulating the mean sea-ice extent, concentration, and thickness as compared to the best available observational data set. The variability of the annual maximum Baltic Sea ice extent is well in line with the observations, but the 1961–2006 trend is underestimated. Capturing the correct ice thickness distribution is more challenging. Based on the simulated ice thickness distribution we estimate the undeformed and deformed ice thickness and concentration in the Baltic Sea, which compares reasonably well with observations.

  11. Tratamento farmacológico do transtorno de personalidade limítrofe: revisão crítica da literatura e desenvolvimento de algoritmos Tratamiento farmacológico del trastorno de personalidad limítrofe: revisión crítica de la literatura y desarrollo de algoritmos Pharmacological treatment of borderline personality disorder: critical review of the literature and development of algorithms

    Directory of Open Access Journals (Sweden)

    André F. Carvalho

    2004-08-01

    Full Text Available INTRODUÇÃO: O transtorno de personalidade limítrofe (TPL é uma síndrome psiquiátrica que causa significativa morbidade e mortalidade para pacientes internados e ambulatoriais tratados por profissionais de saúde mental. Dada a sua alta prevalência na população de pacientes psiquiátricos, esforços são necessários para tratar esse grupo apropriadamente. OBJETIVO: O objetivo do presente artigo é revisar evidências atuais acerca da efetividade das diversas abordagens farmacológicas empregadas como parte do plano de tratamento produzido para indivíduos que enfrentam essa doença. MÉTODOS: Para esse propósito, os autores revisaram o banco de dados MEDLINE em busca de ensaios clínicos publicados entre 1986 e 2003. Borderline personality disorder e clinical trials foram usados com descritores. RESULTADOS: Numerosos trabalhos foram encontrados, mas poucos estudos controlados estavam disponíveis. Notável é o fato de que virtualmente todas as classes de psicofármacos foram testadas nesse grupo de pacientes, comumente com desfechos modestos ou variáveis. Devido a limitações metodológicas na vasta maioria dos ensaios clínicos envolvendo drogas específicas nesse grupo de pacientes, foi difícil estimar o benefício real dos vários agentes testados. A evidência mais forte existe para os inibidores seletivos de serotonina, antipsicóticos e divalproato. DISCUSSÃO: Claramente, mais ensaios clínicos bem delineados são necessários, mas os dados revisados sugerem que psicofármacos são efetivos para tratar sintomas-alvo nesses pacientes. Conclui-se que psicotrópicos são adjuntos úteis às abordagens psicoterapêuticas usualmente empregadas para tratar pacientes limítrofes.INTRODUCCÍON: El trastorno de personalidad limítrofe (TPL es un síndrome psiquiátrico que causa significativa morbididad y mortalidad a pacientes internados y ambulatoriales tratados por profesionales de salud mental. Vista su alta prevalencia en la

  12. What won't Turnstones eat?

    Science.gov (United States)

    Gill, Robert E.

    1986-01-01

    The Turnstone Arenaria interpres probably has one of the most varied diets of any wader species. Besides the 'normal' foods taken (see, e.g., Prater 1972, Nettleship 1973, Jones 1975), a considerable variety of 'unusual' foods and feeding behaviours has also been reported. Items taken include soap, gull excrement, dog food, potato peels, cheese, oatmeal, and the flesh of dead animals, including birds, a sheep Ovis, a wolf Lupus, a cat Felis, and a human corpse (Bell 1961; Campbell 1966; King 1961, 1964, 1982; King 1982; MacDonald & Parmelee 1962; Mercer 1966; Selway & Kendall 1965; Spencer 1966).

  13. NAFTA -- How the Day Was Won.

    Science.gov (United States)

    1994-04-01

    This paper explores the strategy employed by the Clinton Administration to get the North American Free Trade Agreement ( NAFTA ) signed into...law. It covers the period from the time the side agreements to NAFTA were signed in August 1993 until the House vote in November 1993. A...short history of NAFTA is presented followed by a discussion of the leadership of both the pro- NAFTA and anti- NAFTA factions. An analysis of

  14. Caracterización de la estructura de peces ornamentales durante dos períodos hidrológicos en el caño agua limón, departamento de Arauca, Colombia

    Directory of Open Access Journals (Sweden)

    Ruiz Moreno Andrés Ricardo

    2006-06-01

    Full Text Available Se realizó un inventarió de los peces ornamentales en el caño Agua Limón, en el municipio de Arauca, Arauca (Colombia, en los períodos comprendidos de febrero a mayo de 2005 y de septiembre a agosto de 2005. Como estrategia metodológica para el estudio se realizó un esfuerzo de captura de dos horas por jornada empleando como artes de pesca el trasmallo de fibra de nylon y el aro. Se registraron 4.753 individuos que
    corresponden a 74 especies pertenecientes a 21 familias donde las especies más abundantes fueron Ctenobrycon spilurus (22%, Astyanax sp. (18% y Gephyrocharax sp. (10%. Los órdenes con mayor representación específica fueron Characiformes y Siluruformes (reuniendo el 71% de las capturas. Las familias con mayor riqueza de especies fueron Characidae (24 spp. y Loricariidae (12 spp. seguidas por las familias Cichlidae (6 spp., Apteronotidae y Pimelodidae con cuatro especies, Auchenipteridae y Callichthydae con tres especies cada una. La mayor riqueza de especies se encontró en los meses de septiembre, agosto y marzo, se sugiere que estos resultados están relacionados con las variaciones del régimen hidrológico de esta región dando como consecuencia cambios de distribución en los cuerpos de agua que frecuentan las especies. El mes de mayo tiene la menor diversidad y al
    mayor abundancia de especies.

  15. Drosophila Model for the Analysis of Genesis of LIM-kinase 1-Dependent Williams-Beuren Syndrome Cognitive Phenotypes: INDELs, Transposable Elements of the Tc1/Mariner Superfamily and MicroRNAs

    Directory of Open Access Journals (Sweden)

    Elena V. Savvateeva-Popova

    2017-09-01

    Full Text Available Genomic disorders, the syndromes with multiple manifestations, may occur sporadically due to unequal recombination in chromosomal regions with specific architecture. Therefore, each patient may carry an individual structural variant of DNA sequence (SV with small insertions and deletions (INDELs sometimes less than 10 bp. The transposable elements of the Tc1/mariner superfamily are often associated with hotspots for homologous recombination involved in human genetic disorders, such as Williams Beuren Syndromes (WBS with LIM-kinase 1-dependent cognitive defects. The Drosophila melanogaster mutant agnts3 has unusual architecture of the agnostic locus harboring LIMK1: it is a hotspot of chromosome breaks, ectopic contacts, underreplication, and recombination. Here, we present the analysis of LIMK1-containing locus sequencing data in agnts3 and three D. melanogaster wild-type strains—Canton-S, Berlin, and Oregon-R. We found multiple strain-specific SVs, namely, single base changes and small INDEls. The specific feature of agnts3 is 28 bp A/T-rich insertion in intron 1 of LIMK1 and the insertion of mobile S-element from Tc1/mariner superfamily residing ~460 bp downstream LIMK1 3′UTR. Neither of SVs leads to amino acid substitutions in agnts3 LIMK1. However, they apparently affect the nucleosome distribution, non-canonical DNA structure formation and transcriptional factors binding. Interestingly, the overall expression of miRNAs including the biomarkers for human neurological diseases, is drastically reduced in agnts3 relative to the wild-type strains. Thus, LIMK1 DNA structure per se, as well as the pronounced changes in total miRNAs profile, probably lead to LIMK1 dysregulation and complex behavioral dysfunctions observed in agnts3 making this mutant a simple plausible Drosophila model for WBS.

  16. Preferencias en la anidación de tortugas carey (Eretmochelys imbricata y baulas (Dermochelys coriacea en el Refugio Nacional de Vida Silvestre Gandoca Manzanillo, Limón, Costa Rica

    Directory of Open Access Journals (Sweden)

    Lilliana Piedra-Castro

    2015-09-01

    Full Text Available El Caribe costarricense es importante como sitio de alimentación, copulación, anidación y desove de las tortugas marinas, por lo que el presente trabajo pretendió actualizar el patrón de anidación en las tortugas marinas Dermochelys coriacea y Eretmochelys imbricata en el sector Gandoca, del Refugio Nacional de Vida Silvestre Gandoca Manzanillo, Limón, Costa Rica, para proponer medidas de manejo. Se realizaron recorridos nocturnos entre las 8:00 p. m. y 4:00 a. m., la playa se dividió en cinco sectores, en estos se realizaron observaciones directas y de rastros, de las tortugas que elaboraron el nido, entre febrero y agosto del 2011 y 2012. Se registraron tres especies de tortugas marinas, Dermochelys coriacea, Eretmochelys imbricata y Chelonia mydas. La anidación de tortugas baula tuvo su punto máximo entre marzo y julio; por su parte, las carey, entre mayo y junio (2011, y junio hasta agosto en el 2012. Se observó preferencia en la posición de la playa utilizada para construir sus nidos; la baula utiliza principalmente la parte media, mientras que la carey utilizó mayormente la parte baja para anidar (t = 17.2525. Se observó que la baula utilizó frecuentemente el sector C; sin embargo, no se encontraron diferencias en el uso de los sectores. Se concluye que ambas especies tienen preferencias en la selección de la zona de playa en que anidan; la carey en la parte baja cerca de la línea de costa y la baula en la parte media. Además, las tortugas baula utilizan indistintamente los diferentes sectores de la playa estudiada.

  17. Investigación del mercado de vidrio y aluminio como materiales de construcción y remodelación en el Cantón Central de Limón, que permita a la empresa Inversiones Garita S.A. determinar la posible apertura de una nueva división de materias primas

    OpenAIRE

    Garita Alpízar, Pablo Alejandro

    2015-01-01

    Universidad de Costa Rica. Posgrado en Administración y Dirección de Empresas. Maestría Profesional en Administración y Dirección de Empresas, 2015 Esta Práctica Profesional se realizó en la empresa Inversiones Garita S.A., legalmente constituida hace casi 30 años, ubicada en Limón Centro, 275 m norte de Más x Menos, contiguo a la Bomba del Grupo Hayling, Avenida 6. La empresa Inversiones Garita se dirige a dos segmentos: el primero y principal son las personas físicas, asalari...

  18. Controle da ferrugem das folhas do capim-limão [Cymbopogon citratus (DC: Stapf] com produtos naturais Rust control in leaves of lemongrass [Cymbopogon citratus (DC: Stapf] by using natural products

    Directory of Open Access Journals (Sweden)

    E.R. Lorenzetti

    2012-01-01

    Full Text Available Cymbopogon citratus (DC. Stapf é uma planta medicinal pertencente a família Poaceae, perene, importante para a indústria farmacêutica e alimentícia devido ao óleo essencial que produz. Um problema limitante para a produção comercial é a ferrugem, doença cujo agente etiológico é o fungo Puccinia nakanishikii Dietel. O presente trabalho objetivou avaliar a ação de produtos naturais no controle da doença in vitro e in vivo. Para os testes in vitro, empregaram-se os seguintes produtos sobre a germinação de esporos do patógeno: óleos essenciais de eucalipto, palma-rosa, cravo-da-índia, menta, limão, citronela e mil-folhas; extrato pirolenhoso de eucalipto e mentol cristalizado, em diferentes concentrações. Para os testes de campo foram selecionados quatro produtos, o óleo de citronela e de eucalipto, o extrato pirolenhoso, e o mentol. In vitro, todos os agentes mostraram-se promissores no controle do patógeno. Quando em condições in vivo, sob alta severidade da doença no ato da avaliação, os produtos testados foram capazes de reduzir a severidade da doença em comparação com a testemunha. O controle da doença com os agentes naturais variou de 38% (extrato pirolenhoso a 61%(óleo essencial de eucalipto.Cymbopogon citratus (DC. Stapf is a medicinal plant that belongs to the Poaceae family; it is perennial and important for the pharmaceutical and food industry due to the essential oil it produces. A limiting problem for commercial production is rust, a disease that has as etiological agent the fungus Puccinia nakanishikii Dietel. The present study aimed to evaluate the action of natural products on the disease control, in vitro and in vivo. For the in vitro tests, the following products were employed on the germination of the pathogen spores: essential oils from eucalyptus, palmarosa, clove, peppermint, lemon, citronella and yarrow, pyroligneous extract from eucalyptus, and crystallized menthol, at different

  19. Multi-organ expression profiling uncovers a gene module in coronary artery disease involving transendothelial migration of leukocytes and LIM domain binding 2: The Stockholm Atherosclerosis Gene Expression (STAGE) study

    KAUST Repository

    Hägg, Sara

    2009-12-04

    Environmental exposures filtered through the genetic make-up of each individual alter the transcriptional repertoire in organs central to metabolic homeostasis, thereby affecting arterial lipid accumulation, inflammation, and the development of coronary artery disease (CAD). The primary aim of the Stockholm Atherosclerosis Gene Expression (STAGE) study was to determine whether there are functionally associated genes (rather than individual genes) important for CAD development. To this end, two-way clustering was used on 278 transcriptional profiles of liver, skeletal muscle, and visceral fat (n =66/tissue) and atherosclerotic and unaffected arterial wall (n =40/tissue) isolated from CAD patients during coronary artery bypass surgery. The first step, across all mRNA signals (n =15,042/12,621 RefSeqs/genes) in each tissue, resulted in a total of 60 tissue clusters (n= 3958 genes). In the second step (performed within tissue clusters), one atherosclerotic lesion (n =49/48) and one visceral fat (n =59) cluster segregated the patients into two groups that differed in the extent of coronary stenosis (P=0.008 and P=0.00015). The associations of these clusters with coronary atherosclerosis were validated by analyzing carotid atherosclerosis expression profiles. Remarkably, in one cluster (n =55/54) relating to carotid stenosis (P =0.04), 27 genes in the two clusters relating to coronary stenosis were confirmed (n= 16/17, P<10 -27and-30). Genes in the transendothelial migration of leukocytes (TEML) pathway were overrepresented in all three clusters, referred to as the atherosclerosis module (A-module). In a second validation step, using three independent cohorts, the Amodule was found to be genetically enriched with CAD risk by 1.8-fold (P<0.004). The transcription co-factor LIM domain binding 2 (LDB2) was identified as a potential high-hierarchy regulator of the A-module, a notion supported by subnetwork analysis, by cellular and lesion expression of LDB2, and by the

  20. Efeitos de fitorreguladores e nitrato de potássio na germinação de sementes do limão 'volkameriano' Effects of growth regulators and potassium nitrate on 'volkameriana' lemon seed germination

    Directory of Open Access Journals (Sweden)

    E.O. Ono

    1993-12-01

    Full Text Available Foram estudados os efeitos de substâncias reguladoras de crescimento, bem como do nitrato de potássio (KNO3, na germinação de sementes do limão 'volkameriano' (Citrus volkameriana Pasq.. O experimento foi realizado em germinador, contendo papel de filtro umedecido com água destilada e gerbox, como meio para a germinação das sementes. Estas foram retiradas de frutas maduras, lavadas, secas à sombra e armazenadas durante 101 dias em câmara fria. Logo após, foram tratadas com os fitorreguladores e o KNO3 por 24 horas, conforme os tratamentos: H2O; 50 mg/l de GA3; 250 mg/l de GA3; 50 mg/l de GA4 + GA7 + fenilmetilaminopurina; 100 mg/l de GA4 + GA7 + fenilmetilaminopurina; 20 mg/lde fenilmetilaminopurina; 40 mg/lde fenilmetilaminopurina e 0,2% de KNO3. As avaliações foram realizadas depois de 15 dias da semeadura, sendo o intervalo de 2 dias. Através da análise estatística dos resultados obtidos, foi possível concluir que no tratamento com 50 mg/lde GA4 + GA7 + fenilmetilaminopurina houve a maior porcentagem de germinação (89,00% de sementes, num menor tempo médio (22,29 dias.The purpose of this research was to study the effects of growth regulators and potassium nitrate on 'volkameriana' lemon seed germination. The medium for seed germination was filter paper with distilled water. The seeds were removed from ripe fruits, washed, dried and stored at 4-5°C. After this the seeds were treated with growth regulators and potassium nitrate during 24 hours. The treatments were H2O; 50 mg/lof GA3; 250 mg/lof GA3; 50 mg/lof GA4 + GA7 + phenylmethylaminepurine; 100 mg/l of GA4 + GA7 + phenylmethyla-minepurine; 20 mg/lof phenylmethylaminepurine; 40 mg/lof phenylmethylaminepurine and 0,2% of KNO3. The evaluations were performed every two days, starting 15 days after seeding. The moisture with GA4 + GA7 plus phenylmethylaminepurine at 50 mg/lproved to be the most beneficial in enhancing seed germination.

  1. Produção de mudas de limão cravo em substrato com biofertilizante bovino irrigado com águas salinas Production of rangpur lemon seedlings in substrate with bovine biofertilizer irrigated with saline water

    Directory of Open Access Journals (Sweden)

    Alex Matheus Rebequi

    2009-12-01

    Full Text Available Um experimento foi instalado no período de março a maio de 2008, em ambiente telado, para avaliar os efeitos da salinidade da água de irrigação e do biofertilizante bovino na formação de mudas de limão cravo. O substrato foi material dos primeiros 20 cm de um Argissolo Amarelo Distrófico não salino, com os tratamentos dispostos em esquema fatorial 5 x 2 com seis repetições, referente a cinco valores de condutividades elétrica da água de irrigação (0,5; 1,0; 2,0; 3,0 e 4,0 dS.m-1, obtidos pela diluição de uma água fortemente salina (14,3 dS.m-1 com água não salina (0,5 dS.m-1, em solo sem e com biofertilizante comum, diluído em água na proporção de 1:1 aplicado ao nível de 10% do volume do substrato, um dia antes da semeadura. Pelos resultados, se constatou superioridade dos dados obtidos nos tratamentos com o biofertilizante em relação aos dos tratamentos sem o respectivo insumo.One experiment was developed during the period from March to May of 2008 in a canvassed shelter to evaluate the effects of saline water and bovine biofertilizer on seedling formation of rangpur lemon. The substrate used was composed by soil at 20 cm depth of a non saline yellow distrofic Oxisoil, with treatments distributed in a factorial arrangement 5 x 2 with six repetitions, referring to water electrical conductivity (0.5, 1.0, 2.0, 3.0 e 4.0 dS.m-1 obtained by dilution of saline water (14.3 dS.m-1 with non saline water (0.5 dS.m-1 in soil with and without biofertilizer diluted in water 1:1 proportion applied in 10% of substrate volume, one day before sowing. According to results, it was observed a superiority of data from treatments with biofertilizer in relation to those without this product.

  2. Hospital Outpatient Prospective Payment System (OPPS) Lim...

    Data.gov (United States)

    U.S. Department of Health & Human Services — Hospital Outpatient Prospective Payment System (OPPS) Limited Data Set This file contains select claim level data and is derived from 2010 hospital outpatient PPS...

  3. OJ Lim Tung TRANSBOUNDARY MOVEMENTS OF GENETICALLY ...

    African Journals Online (AJOL)

    10332324

    Views differed on the need to regulate genetically modified (GM) crops (Schnier 2001 Fordham. Envtl LJ 385) and the ... LMOs can be considered as a sub-group of GMOs according to the Food and Agriculture. Organisation ..... See FAO-WHO 2002 www.who.int/foodsafety/codex/en/codex_eval_report_en.pdf. See Codex.

  4. Sugarcane Molasse and Whey as Additives in the Silage of Lemongrass (Cymbopogon citratus [DC.] Stapf Leaves Melaza de Caña de Azúcar y Suero de Leche como Aditivos en el Ensilaje de Hojas de Zacate de Limón (Cymbopogon citratus [DC.] Stapf

    Directory of Open Access Journals (Sweden)

    Lucía María Cristina Ventura-Canseco

    2012-03-01

    Full Text Available After extraction of essential oil from lemongrass (Cymbopogon citratus [DC.] Stapf leaves by steam distillation (heat treatment, large amounts of organic wastes are obtained. This by-product could easily be used as animal feed. The potential of sugarcane molasse and whey as additives to ensile lemongrass leaves was investigated. The vegetative material was obtained after essential oils were extracted from lemongrass leaves with steam distillation. Lemongrass leaves were chopped, mixed with sugarcane molasse and whey, placed in cylindrical plastic containers, hermetically closed. The experimental design for pH optimization was a response surface 3-level factorial design 3² with three replicates. Sugarcane molasse at 5, 10 and 15% (w/w and whey at 20, 25 and 30% (w/w were used. The pH of the silage decreased significantly in each treatment, but it was faster when sugarcane molasse was added. The lactic acid concentration was 2.8 g kg-1 DM in silage amended with 15% molasse plus 25% whey and was higher than in silage supplemented with commercial additive after 15 d. In conclusion, it was shown that lemongrass leaves obtained as by product after extracting essential oils can be effectively ensiled with whey and sugarcane molasse as additives inducing a faster production of lactic acid.Después de la extracción del aceite esencial de zacate limón (Cymbopogon citratus [DC.] Stapf por destilación con vapor (tratamiento térmico se obtiene un residuo. Este residuo podría ser utilizado para alimentación animal. El potencial de la melaza de caña y suero de leche como aditivos para ensilar hojas de zacate limón fue investigado. El material vegetal se obtuvo después que los aceites esenciales se extrajeron de las hojas de zacate limón usando destilación con vapor. Las hojas de zacate limón se picaron, mezclaron con melaza de caña y suero de leche y se colocaron en recipientes cilíndricos de plástico y se cerraron herméticamente. El dise

  5. Atividades antioxidante e fungitóxica do óleo essencial de capim-limão e do citral Antioxidant and fungitoxic activities of the lemongrass essential oil and citral

    Directory of Open Access Journals (Sweden)

    Luiz Gustavo de Lima Guimarães

    2011-06-01

    Full Text Available Tendo em vista a importância dos óleos essenciais, objetivou-se, com este trabalho, avaliar a atividade antioxidante e os efeitos fungitóxicos do óleo essencial de capim-limão e do seu constituinte majoritário citral sobre a inibição micelial dos fitopatógenos Fusarium oxysporum cubense, Colletotrichum gloeosporioides, Bipolaris sp. e Alternaria alternata. A atividade antioxidante foi realizada, empregando os métodos de redução do radical livre DPPH e o ensaio de oxidação do sistema b-caroteno/ácido linoléico. Para cada metodologia, utilizou-se o delineamento inteiramente casualizado em esquema fatorial de 4 x 5, sendo quatro compostos (óleo essencial, citral, timol e α-tocoferol e cinco concentrações (5; 10; 25; 50 e 100 µg L-1, com três repetições Os ensaios para verificação das atividades fungitóxicas foram realizados aplicando o teste de fumigação in vitro sobre a inibição micelial dos fungos fitopatogênicos estudados. Os tratamentos foram dispostos de forma inteiramente casualizada, com três repetições e em esquema fatorial com arranjo variável entre os fitopatógenos. O óleo essencial e o citral apresentaram pequena atividade antioxidante perante a metodologia que avalia a redução do radical estável DPPH, no entanto, perante a metodologia que emprega o sistema emulsificado β-caroteno/ácido linoléico estes compostos apresentaram atividades antioxidantes significativas. Nas atividades fungitóxicas, o óleo essencial e o citral apresentaram uma maior atividade sobre o fitopatógeno Alternaria alternata. Em relação aos valores de IC50 os menores valores apresentados pelo óleo essencial (75,83 µg mL-1 e pelo citral (58,24 µg mL-1 foram sobre o Bipolaris sp. O citral causou as maiores inibições miceliais, para todos os fitopatógenos.Given the importance of essential oils, this study evaluated the antioxidant activity and fungitoxic effects of lemongrass essential oil and its main constituent

  6. Retos y desafíos para el fortalecimiento y apoyo de las capacidades de gestión empresarial a través del trabajo comunal universitario (TCU) en las PYMES de Pococí, Limón, Costa Rica

    OpenAIRE

    Sandí Delgado, Juan Carlos; Brenes Granados, Cristian

    2011-01-01

    Este artículo se centra en la elaboración de un diagnóstico cuyo fin será determinar los retos y desafíos para el fortalecimiento y apoyo de las capacidades de gestión empresarial de las organizaciones públicas y PYMES, ubicadas en el Cantón de Pococí, Provincia de Limón, Costa Rica. La investigación llevada a cabo fue de tipo cuantitativa. Se efectuó una revisión bibliográfica y los datos primarios fueron recolectados a través de la aplicación de cuestionarios con preguntas...

  7. Retos y desafíos para el fortalecimiento y apoyo de las capacidades de gestión empresarial a través del Trabajo Comunal Universitario (TCU) en las PYMES de Pococí, Limón, Costa Rica

    OpenAIRE

    Brenes Granados, Cristian; Sandí Delgado, Juan Carlos

    2011-01-01

    Este artículo se centra en la elaboración de un diagnóstico cuyo fin será determinar los retos y desafíos para el fortalecimiento y apoyo de las capacidades de gestión empresarial de las organizaciones públicas y PYMES, ubicadas en el Cantón de Pococí, Provincia de Limón, Costa Rica. La investigación llevada a cabo fue de tipo cuantitativa. Se efectuó una revisión bibliográfica y los datos primarios fueron recolectados a través de la aplicación de cuestionarios con preguntas semi- c...

  8. Ocorrência do vírus "vein enation (woody gall" em limão verdadeiro (Citrus limon burm. cv siciliano em Santa Catarina Occurrence of the "vein enetion (woody gall" virus in lemon (Citrus limon Burm. cv siciliano in the Santa Catarina state

    Directory of Open Access Journals (Sweden)

    O.L. KOLLER

    1998-01-01

    Full Text Available Relata-se a ocorrência do vírus causador da doença "vein enation", também conhecida por "woody gall", em plantas de limão verdadeiro, em Santa Catarina, introduzido em pomar comercial através de mudas adquiridas em São Paulo. Limão `Volkameriano' enxertado com material contaminado desenvolveu os sintomas característicos de "woody gall", com grande intensidade no Alto Vale do Itajaí, e com menor intensidade no Litoral Norte de Santa Catarina. Constatou-se redução no desenvolvimento das plantas e na produção de frutos. Todo material sabidamente contaminado foi erradicado. Sugere-se às instituições oficiais de pesquisa a realização de testes de indexação para esta virose em seus bancos de germoplasma, uma vez que grande parte das variedades cítricas não desenvolve os sintomas da doença.The presence of the vein enation virus, also known as woody gall virus, in Citrus limon, in Santa Catarina State, is reported. The virus was introduced through contamined nursery plants acquired in the São Paulo State. `Volkamer' lemon budded with contamined buds has developed typical woody gall symptoms, more frequently in Alto Vale do Itajaí (High Itajaí River Valley, and less frequently in Santa Catarina's Northern Coast. A significant decrease in plant development and fruit yield was been observed. All known contaminated material was erradicated. It is suggested that official research institutions carry out indexing tests for this virosis at their germplasm banks, since part of the citrus varieties fail to develop symptoms of this disease.

  9. Inversão da sacarose utilizando ácido cítrico e suco de limão para preparo de dieta energética de Apis mellifera Linnaeus, 1758 Inversion of the sucrose using citric acid and lemon juice for preparing energetic diet of Apis mellifera Linnaeus, 1758

    Directory of Open Access Journals (Sweden)

    Deodoro Magno Brighenti

    2011-04-01

    Full Text Available Em época de escassez de néctar, pode-se fornecer ao enxame uma suplementação alimentar utilizando "açúcar invertido" que é obtido pela hidrólise da sacarose em meio ácido por aquecimento, formando uma mistura de glicose e frutose. O ácido normalmente utilizado em tal reação é o ácido cítrico, no entanto, diante da dificuldade de pequenos produtores apícolas em obterem tal produto comercialmente, uma alternativa seria substituí-lo pela utilização de suco de limões. Sendo assim, o objetivo deste trabalho foi quantificar a inversão da sacarose em dietas para operárias de Apis mellifera, empregando-se o ácido cítrico e sucos de limões. Prepararam-se 21 soluções aquosas de açúcar cristal na proporção de 100 g/100 mL, colocando-se em cada uma 1,0; 2,0; 3,0; 5,0; 10,0; 15,0 ou 20,0 mL de suco dos limões Galego [Citrus aurantifolia (C. Swingle], Tahiti [Citrus latifolia Tanaka] ou Cravo [Citrus limonia (L. Osbeck]. Além dessas, outras seis soluções aquosas de açúcar na mesma proporção foram preparadas adicionando-se 0,1; 0,16; 0,3; 0,5 e 0,7 g de ácido cítrico e uma para testemunha. Quantificou-se a inversão pelo método de Somogyi-Nelson. Para o limão Cravo foi encontrada a menor porcentagem de inversão. Em relação a adição de ácido cítrico, constatou-se que ao colocar 0,1 g, a inversão foi estimada em 12,2% enquanto que, com a adição de 0,16 g, a inversão seria de 18,8%. A quantidade máxima de ácido cítrico a ser adicionada foi estimada em 0,18 g adotando como critério o pH médio de 3,3 dos méis de abelhas africanizadas. Para os sucos dos limões Galego, Tahiti e Cravo, quando utilizados como substitutos do ácido cítrico, estimou-se a quantidade máxima a ser adicionada sendo igual a 2,1; 3,6 e 5,3 mL, respectivamente, para cada 100 g de açúcar em 100 mL de água, para o pH fixado em 3,3. Considerando-se a inversão e o pH, o suco do limão Tahiti forneceu melhores resultados.In times of

  10. Eficacia de tres estrobilurinas para el control de mancha rojiza (Guignardia mangiferae y mancha negra (Guignardia citricarpa en frutos de limón, en Tucumán, República Argentina Efficiency of three strobilurins to control reddish spot (Guignardia mangiferae and black spot (Guignardia citricarpa in lemon fruits in Tucumán, Argentina

    Directory of Open Access Journals (Sweden)

    Gabriela M. Fogliata

    2011-06-01

    Full Text Available La Argentina lidera la producción e industrialización mundial de limón. Tucumán produce el 87% del total nacional, destinando 65% para su industrialización y 35% para su comercialización como fruta fresca, principalmente en exportaciones. Para ello, se requieren frutos de calidad y libres de enfermedades, especialmente de aquellas causadas por patógenos considerados cuarentenarios en los mercados de destino. En Tucumán, están presentes la mancha negra de los cítricos, causada por Guignardia citricarpa (Phyllosticta citricarpa, patógeno cuarentenario para importantes mercados consumidores, y en mayor prevalencia, la mancha rojiza o moteado, causada por G. mangiferae (P. capitalensis, hongo no cuarentenario. Ambas enfermedades se controlan con fungicidas cúpricos, estrobilurinas, mancozeb y bencimidazoles. Se realizaron cinco ensayos para evaluar la eficacia de tres estrobilurinas, azoxistrobina, pyraclostrobin y trifloxistrobin, para controlar mancha rojiza (campañas 2004/2005, 2005/2006 y 2006/2007 y mancha negra (2007/2008 y 2008/2009 en frutos de limón en Tucumán. Se realizaron una y dos aplicaciones de estrobilurinas con oxicloruro de cobre, en un esquema de cuatro y cinco aplicaciones de cúpricos, cada treinta días desde caída de pétalos. Se utilizaron tratamientos con oxicloruro de cobre solo o en mezcla con mancozeb, como testigos químicos. Se evaluó la incidencia de las enfermedades en julio y se calculó la eficacia de los tratamientos. Los más eficaces para controlar mancha negra y mancha rojiza fueron los que incluyeron una o dos aplicaciones de estrobilurinas, sin diferencias entre sí, superando al cúprico e igualando o superando a la mezcla cúprico-mancozeb. Estos resultados demostraron la eficacia de las estrobilurinas para controlar mancha negra y mancha rojiza en frutos de limón.Argentina leads lemon world production and industrialization. The province of Tucumán generates 87% of national production

  11. Caracterização da composição química e do rendimento dos resíduos industriais do limão Tahiti (Citrus latifolia Tanaka Chemical composition and Tahiti lime industrial residues output characterization

    Directory of Open Access Journals (Sweden)

    Luciana Maria Vieira Lopes Mendonça

    2006-12-01

    Full Text Available A indústria de sucos utiliza apenas de 40% a 50% dos frutos, sendo o restante considerado resíduo industrial. Estes resíduos apresentam-se ricos em alguns componentes como pectina, vitamina C e fibras dietárias que o tornam matéria-prima para a indústria alimentícia, farmacêutica e de rações. Visando o aproveitamento dos resíduos industriais do limão Tahiti para tais fins, caracterizou-se a composição centesimal, os teores de fibras, de pectina e de vitamina C presentes nas frações flavedo, albedo e bagaço do fruto. A partir da avaliação dos dados pelo teste de Scott Knott 5% de probabilidade, observou-se que os teores de cinzas, pectina, proteína, vitamina C e fibra bruta foram diferentes no flavedo, albedo e bagaço. O resíduo industrial do limão Tahiti tem um grande potencial para uso em formulação de rações para animais, dada a sua composição química, assim como poderá ser usado para a extração de fibras, pectina, vitamina C e óleos.The juice industry makes use of only 40 to 50% of the fruit and its remainder is considered industrial residue. This residue is very rich in some of its compounds such as pectin, ascorbic acid and dietary fibers making it into raw material for the food industry, pharmaceutics and animal food. With the purpose of using the industrial residue of Tahiti lime for such purposes, the centesimal composition, fiber contents, pectin and vitamin C contained in flavedo fractions, albedo and fruit pulp were characterized. From the evaluation for the Scott Knott's test to 5% of probability, it was observed that the ash content, pectin, protein, vitamin C and rude fiber were different for flavedo, albedo and pulp. Tahiti lime industrial residue has a great potential for animal food formulation, considering its chemical composition, as well as the fact that it can be used for fiber extraction, pectin, vitamin C and oils.

  12. Drying of sicilian lemon residue: influence of process variables on the evaluation of the dietary fiber produced Secagem do resíduo de limão siciliano: influência das variáveis de processo na avaliação da fibra alimentar produzida

    Directory of Open Access Journals (Sweden)

    Vanessa Martins Silva

    2010-06-01

    Full Text Available In this study, the effect of the process variables of the air-drying of Sicilian lemon residues on some technological properties of the fibers produced was studied. The determination and modeling of desorption isotherms were used to establish the equilibrium moisture content at 60, 75, and 90 °C using the static method with 8 saturated salt solutions. The best fit was obtained with BET and GAB models. The drying process was conducted in a vertical tray dryer and delineated according to a central composite experimental design (2² using the following as factors: air velocity (0.5, 0.75 and 1 m/s and temperature (60, 75, and 90 °C, and it presented a good fit to the exponential model (R² > 99.9%. The experimental design responses evaluated were the technological properties of the fibers: water-holding, oil-holding, and swelling capacity. Since these properties were present in high levels, the lemon residues could be used to increase content of fibers in foods resulting in the addition of nutritional benefits for the consumers.Estudou-se o efeito das variáveis de processo da secagem do resíduo de limão siciliano sobre algumas propriedades tecnológicas das fibras produzidas. A determinação e modelagem das isotermas de dessorção foram utilizadas para determinar o conteúdo de umidade de equilíbrio a 60, 75 e 90 °C, através do método gravimétrico estático com 8 soluções salinas saturadas. O melhor ajuste dos dados experimentais foi encontrado com os modelos de BET e GAB. A secagem foi conduzida em um secador vertical de bandejas e delineada de acordo com um planejamento experimental (2², tendo como fatores: velocidade do ar (0,5, 0,75 e 1 m/s e temperatura (60, 75 e 90 °C, apresentando bons ajustes ao modelo exponencial (R² > 99.9%. As respostas do planejamento avaliadas foram relacionadas a algumas propriedades tecnológicas das fibras, como a capacidade de absorção em água e óleo e o volume de intumescimento. Uma vez que

  13. African Journal of Biotechnology - Vol 12, No 15 (2013)

    African Journals Online (AJOL)

    Sensitivity of tomato (Solanum lycopersicum) cultivars from Turkey to bacterial speck (Pseudomonas syringae pv. tomato) · EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT ... Chi-Won Lim, Yeon-Kye Kim, So-mi Yeun, Moon-Hee Lee, Ho-Sung Moon, Na-Young Yoon, Ho-Dong Yoon, Hee-Yeon Park, Doo-Seog Lee ...

  14. Efeito alelopático de sabugueiro e capim-limão na germinação de picão-preto e soja = Allelophatic effect of Sambucus australis Cham. and Schltdl. and Cymbopogon citratus (DC Stapf. in the germination of Bidens pilosa L. and soybeans

    Directory of Open Access Journals (Sweden)

    Andréa Maria Teixeira Fortes

    2009-04-01

    Full Text Available As plantas invasoras são constantes e diminuem a produtividade das culturas por competirem por espaço, nutrientes e água. Dessa forma, os agricultores adotam, em grande escala, produtos químicos eficientes no controle da lavoura e com alta toxicidade ao meioambiente. Existem, no entanto, formas alternativas para o controle de invasoras, por meio de aleloquímicos presentes em algumas plantas, dentre elas, as medicinais. Este trabalho tem como objetivo analisar as propriedades alelopáticas dos extratos das plantas medicinais Cymbopogon citratus (DC Stapf. e Sambucus australis Cham. and Schltdl. em inibir a germinação de Bidens pilosa L., sem interferir na germinação de Glycine max L. Merrill. Os extratos foram obtidos triturandose 200 g de folhas com 1 L de água destilada. As sementes foram mantidas em B.O.D. à temperatura de 25°C, com fotoperíodo de 12h de luz. Nas condições em que foram realizados os experimentos, constatou-se que o extrato de capim-limão inibiu a germinação de picão-preto sem que este inibisse a germinação da soja, enquanto o extrato de sabugueiro inibiu a germinação de picão-preto e a germinação da soja. Assim, indica-se a utilização do capim-limão, como um herbicida natural para o picão-preto.Agriculture has been suffering adaptations throughout time, from hard hand labor to the most advanced sowing and harvesting techniques. Invasive plants are a constant, diminishing productivity by competing for space, nutrients, and water. Therefore, farmers have adopted, on alarge scale, the use of efficient synthetic chemicals, which are highly toxic to the environment, in order to control plant production. However, there are other alternative means to control those competitors: using allelochemicals present in some plants, such as medicinal ones. The objective of this paper is to analyze allelophatic properties of the medicinal plants Cymbopogon citratus (DC Stapf. and Sambucus australis Cham. and Schltdl

  15. In vitro antimicrobial activity of essential oils from oregano, garlic, clove and lemon against pathogenic bacteria isolated from Anomalocardia brasilianaAtividade antimicrobiana in vitro dos óleos essenciais de orégano, alho, cravo e limão sobre bactérias patogênicas isoladas de vôngole

    Directory of Open Access Journals (Sweden)

    Tânia Fraga Barros

    2011-10-01

    Full Text Available Natural preservative substances are an efficient and economic alternative, because the aromatical plants and rich spices in essential oils characterized by a notable are gotten from antimicrobial activity, and for this reason, its derived products can be used to delay or to inhibit the growth of microorganisms. The objective of this study was to evaluate the antibacterial activity of essential oils of clove, limon, oregano (Origanum vulgare ssp. Hirtum and garlic several species of bacteria like Staphylococcus aureus and Escherichia coli isolated of vongole (Anomalocardia Brasiliana and bacteria standard ATCC (American Type Culture Collection: Escherichia coli, Staphylococcus aureus and Salmonella cholerasuis, through diffusion test and after it was determinate the Minimum Inhibitory Concentration (MIC. In this study it was observed that the garlic essential oil presented antibacterial activity front the S. aureus and the S. cholerasuis.; already the oils of clove and oregano (Origanum vulgare ssp. Hirtum had presented activity front to all the analyzed bacteria, however the oregano oil presented the bigger bacterial inhibition, 26.7mm e 29,3mm for E. coli e S. aureus respectively. The essential oil of lemon did not demonstrate antibacterial activity. In such a way the oregano and clove essential oils that they had presented antibacterial activity appeared to be the most preferable agent for future research.Antimicrobianos de origem natural são alternativas eficazes e econômicas, pois são obtidos a partir das plantas aromáticas e especiarias ricas em óleos essenciais caracterizados por uma notável atividade antimicrobiana, e por esta razão, seus produtos derivados podem ser usados para retardar ou inibir a multiplicação microbiana. O objetivo deste estudo foi avaliar a atividade antibacteriana dos óleos essenciais de cravo, limão, orégano e alho sobre as cepas de Staphylococcus aureus e Escherichia coli isolados do v

  16. Secagem e fragmentação da matéria seca no rendimento e composição do óleo essencial de capim-limão Yield and composition of essential oil of lemongrass in different drying and fragmentation conditions

    Directory of Open Access Journals (Sweden)

    Larissa C. do B. Costa

    2005-12-01

    Full Text Available Este estudo foi conduzido com objetivo de determinar o tipo de secagem e a fragmentação das folhas de capim-limão para otimizar o rendimento extrativo do óleo essencial. Foram estabelecidos 6 tratamentos com 2 tipos de secagem (estufa de ventilação forçada a 40ºC e sala com desumidificador e 3 tamanhos de fragmentos das folhas secas (pulverização em moinho, fragmentos com 1 e com 20 cm de comprimento, com 4 repetições. O óleo essencial foi extraído por hidrodestilação durante 2 horas. O maior rendimento de óleo essencial foi obtido com o material seco na sala com desumidificador, não havendo diferenças significativas para os tamanhos da folha. O componente mais abundante no óleo essencial foi o citral que também apresentou as maiores concentrações nas folhas secas em desumidificador.In this study the drying and fragmentation conditions of lemongrass leaves were determined, to increase the essential oil yield. Four replications of six treatments were studied with 2 drying methodologies (oven-drying at 40ºC and room temperature using moisture dryer and 3 fragmentation sizes (powder obtained in mill, 1 cm and 20 cm fragments. The essential oil was extracted in Clevenger's modified apparatus during 2 hours. The higher essential oil yield and citral content was obtained with the leaves dried under room temperature using moisture dryer, with no significant differences in the fragmentation sizes.

  17. I Won't Back down from Anyone!

    Science.gov (United States)

    Pfeifer, Douglas

    2013-01-01

    Routine life stressors can trigger anger and violence with children who have poor emotional regulation. This article describes "Response Ability Pathways" (RAP) strategies that equip youth in managing these daily challenges. The strategies require establishing steps to gain the young persons trust and providing alternative methods to…

  18. An 'Active' Workstation Won't Lower Your Job Performance

    Science.gov (United States)

    ... on the job. Alderman is vice chair of kinesiology and health at Rutgers University in New Brunswick, ... Alderman, Ph.D., associate professor and vice chair, kinesiology and health, Rutgers University, New Brunswick, N.J.; ...

  19. Babies Won't Wait: Early Intervention Challenges Illinois.

    Science.gov (United States)

    Voices for Illinois Children, Chicago.

    As a result of federal law Public Law 99-457, Illinois has the opportunity to provide early intervention for at-risk children up to 3 years of age. These children have developmental delays, such as cerebral palsy, or are cocaine or alcohol babies. The legislative history and current status of Public Law 99-457 as it relates to the planning of…

  20. Why Won't They Just Do It?

    Science.gov (United States)

    Gilbride, Dennis; Stensrud, Robert

    2008-01-01

    The gap (structural hole) between the manner in which rehabilitation agencies and business are structured, organized and managed has grown exponentially over the past 10-20 years. Three key changes have radically transformed American business: the globalization of financial capital and competition, the information technology revolution, and the…

  1. We won't repeat the mistakes of the past.

    Science.gov (United States)

    Amanor, A

    1991-09-01

    The Planned Parenthood Association of Ghana and the country's Ministry of Health have seized on an innovative new method for promoting immunization coverage -- a baby contest. The event seeks to promote the benefits of good health habits, a sound environment, and immunization on a child's development. The contest is designed to determine whether the mother has understood the educational lessons concerning family planning and family health given at the immunization centers and welfare clinics. The prize for winning the contest consists of 3 plastic basins, bars of bath soap, and a white shirt. In order to take part in the baby contest, a mother has to demonstrate the following: that she took 2 doses of tetanus vaccine during pregnancy; that she is able to administer first aid and oral rehydration therapy; that she has a certain level of knowledge concerning family planning methods, environmental sanitation, and personal hygiene; and that she is able to prepare Weanimix, a local weaning food for children. The 1st baby contest was held in December 1989 in the 9 communities that form the Integrated Family Planning, Nutrition and Parasite Control Project (IP) area. This 1st competition succeeded in getting 513 mothers to complete their immunization schedules prior to the event. Because the initial contests took place in remote villages, they received little media coverage, which affected attendance. But as more contests were held and more people became involved, the media picked up the story, further increasing participation. Organizers indicate that the number of people taking part in the contests, as well as the number of children being immunized, has increased steadily every month.

  2. Who Won the Debate in Women Education? Rousseau or Wollstonecraft?

    Science.gov (United States)

    Owusu-Gyamfi, Clifford

    2016-01-01

    Curriculum framework in the education of children became debatable during the enlightenment. Jean-Jacque Rousseau's treatise, "Emile," outlined an educational curriculum based on natural rights. Rousseau thought education should be based on espousing and exploring the natural abilities of a person. Therefore, since women have a natural…

  3. Attention, Predation, Counterintuition:Why Dracula Won't Die

    OpenAIRE

    Clasen, Mathias

    2012-01-01

    Bram Stoker’s seminal horror novel Dracula (1897) has been subjected to a vast number of different critical readings, many of which are deeply flawed, e.g. by proceeding from defunct psychological theories. Incorporating recent advances in evolutionary social science, I offer a biocultural reading of Dracula to account for the novel’s impact and resilience. Dracula connected squarely with late-Victorian anxieties, but the novel also appeals to trans-historical adaptive dispositions. I analyze...

  4. The King Won't Leave the Bathtub!

    Science.gov (United States)

    Bowie, Barbara Kay; Rosenthal, Bonnie L.

    1988-01-01

    Discusses the creative techniques used in eight recently published picture books deemed "age appropriate" for three- to seven-year-olds. Urges preschool teachers to familiarize themselves with available books, and suggests a technique for incorporating literature into the curriculum. Offers a bibliography of story, science, alphabet, and "must…

  5. Children Who Won't Go to School (Separation Anxiety)

    Science.gov (United States)

    ... professional help. Refusal to go to school often begins following a period at home in which the child has become closer to ... intensive treatment. Excessive fears and panic about leaving home/parents and going to school can be successfully ... you find Facts for Families © helpful and would like to make good mental health a reality, consider donating to the Campaign for ...

  6. Fearing Our Students Won't Help Them

    Science.gov (United States)

    Pavela, Gary

    2008-01-01

    This article argues that colleges should not dismiss troubled students first and ask questions later. There are better ways to prevent campus violence than trying to predict students' future behavior, including mental-health support and thoughtful, responsible risk assessment. While no panacea exists, there are helpful, proven strategies: (1)…

  7. Classroom Problems That Won't Go Away.

    Science.gov (United States)

    Warner, Laverne; Lynch, Sharon

    2003-01-01

    Discusses chronic behavior problems that occur in early childhood classrooms and the need to intervene at an early age to prevent continued conduct problems. Examines different kinds of challenging behaviors and motivations for them. Suggests intervention methods to prevent antisocial behavior and strategies for teaching children alternative…

  8. How Washington State doctors battled it and won.

    Science.gov (United States)

    Keith, D M

    1988-03-01

    Mandatory medical assignment bills have been presented to the legislatures of 16 states since 1985, when a bill passed in Massachusetts tied acceptance of assignment to medical licensure, In November 1987, an initiative appeared on the Washington State voter's ballot asking that it be considered a consumer protection violation for physicians to charge more than Medicare's "reasonable" fee. This was the first time that the issue was presented to the registered voters of any state. This article details the way in which the Washington State Medical Association combatted the initiative and turned around an electorate that was 68% in favor, in August, to a final ballot of 63.9% opposed.

  9. TEM Characterization of W-O-N Coatings

    NARCIS (Netherlands)

    Parreira, N.M.G.; Pei, Y.T.; Galvan, D.; Polcar, T.; Hosson, J.Th.M. De; Cavaleiro, A.

    Recently, a new class of coatings based on oxynitrides has drawn much attention in the research field as well as in industrial applications, as shown by either the large numbers of recent publications on TM O N systems (TM—transition metal) such as Ti-O-N, Zr-O-N and Ta-O-N, or the development of Si

  10. Why I Won’t Be a Prime Contractor

    Science.gov (United States)

    2015-02-01

    ticable . . . .” (FAR 13.104) No brand loyalty . If you do an excellent job, the best you can hope for is a good past performance review, which may help...return is predictable. Remember that the owners of some government contractor firms are largely widows and orphans and retired public employees ...are subject to the FCA, the “Lincoln Law,” which includes treble damages. Under the FCA, qui tam lawsuits can be initiated by whistleblowers who hope

  11. It Won't Win an Academy Award

    Science.gov (United States)

    Rathz, David V.

    1972-01-01

    The author and a colleague introduced a program where the students decided what they would learn for the year. The result was a film designed, researched, acted and produced by the students. The process of filming Of Mice and Men" rather than the product counted the most. (Author/AS)

  12. [A battle won: the elimination of poliomyelitis in Cuba].

    Science.gov (United States)

    Chaple, Enrique Beldarraín

    2015-01-01

    Poliomyelitis was introduced in Cuba in the late nineteenth century by American residents in Isla de Pinos. The first epidemics occurred in 1906 and 1909 and increased in intensity between 1930 and 1958. The scope of the paper is to reconstruct the history of the disease and its epidemics in Cuba prior to 1961, the first National Polio Vaccination Campaign (1962) and its results, as well as analyze the ongoing annual vaccination campaigns through to certified elimination of the disease (1994). The logical historical method was used and archival documents and statistics from the Ministry of Health on morbidity and mortality through 2000 were reviewed. Gross morbidity and mortality rates were calculated and interviews with key figures were conducted.

  13. Why fat taxes won't make us thin.

    Science.gov (United States)

    Cornelsen, Laura; Green, Rosemary; Dangour, Alan; Smith, Richard

    2015-03-01

    Increasing prevalence of overweight and obesity has led policy-makers to consider health-related taxes to limit the consumption of unhealthy foods and beverages. Such taxes are currently already in place in countries in Europe (e.g. Hungary, France and Finland) and in various states in the USA. Although these taxes are possibly efficient in reducing by a small amount the consumption of targeted products if the tax is fully transmitted to the consumer, there is too little available evidence on what will be consumed instead and whether these food substitutions undermine the hoped-for health benefits of the tax. We also know very little on how the food supply side will respond and what overall impact this will have. Without a proper appreciation of the potential indirect impacts we do not know the overall impact of taxes foods on unhealthy foods and beverages and further that there is a very real possibility that they may not be beneficial for health after all. © The Author 2014. Published by Oxford University Press on behalf of Faculty of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  14. Organisational learning won't be turned off

    DEFF Research Database (Denmark)

    Elkjær, Bente

    2012-01-01

    made with reference to ideas of education, i.e. intentional processes of the production of knowledge. In this paper, I argue that learning and organisational learning does not primarily appear as a result of intended processes but often as the opposite, i.e. as a struggle to maintain the old and create...... this history of organisational learning I introduce a pragmatist understanding of organisational learning (Elkjaer, 2003a, 2004; Elkjaer & Simpson, 2011). These different versions of organisational learning draw upon specific understandings of what is learning, and how to conceptualise enterprises...

  15. Barriers to Communication: Why Executives Won't Talk.

    Science.gov (United States)

    Fox, James F.

    The thesis of this paper is that successful leaders in business and the professions have shown reluctance to assume leadership in the world of ideas, a reluctance they should attempt to overcome. The paper first examines some barriers and constraints that interfere with the clear communication of business leaders' ideals and purposes, such as the…

  16. Information Literacy: The Battle We Won That We Lost?

    Science.gov (United States)

    Cowan, Susanna M.

    2014-01-01

    As we continue to revise our formal definitions of "information literacy" and to hone our delivery of information literacy across higher education, have we failed to see that information literacy as a programmatic aim, for all of its successes to date, is no longer relevant? The essay charts how the institutionalization of information…

  17. Signal Corps Retention: The Incentive Plan Won’t Help

    Science.gov (United States)

    2008-02-19

    require all signal officers to have certifications before graduation, such as Certified CISCO Network Administrator ( CCNA ), or equivalent. SOBC...Signal Officer Basic Course Curriculum”. 2007. 14 Dec. 2007 <https://www.us.army.mil/suite/doc/6517877&inline=true> 5. Course Catalog: CCNA Courses...12 Bibliography Course Catalog: CCNA Courses 1 through 4. 2007. 16 Dec. 2007 < www.cisco.com/web/learning/netacad /course_catalog

  18. Wisdom won from illness: the psychoanalytic grasp of human being.

    Science.gov (United States)

    Lear, Jonathan

    2014-08-01

    From its inception psychoanalysis claimed not merely to be an effective therapy for psychological suffering, but to shed light on the human condition. But what kind of insight does psychoanalysis offer? This paper locates psychoanalysis in the western philosophical tradition, arguing that psychoanalysis provides not only theoretical wisdom about the human, but practical wisdom of a peculiar kind. The human mind, through its self-conscious understanding can be immediately and directly efficacious in shaping its own structure. Copyright © 2014 Institute of Psychoanalysis.

  19. Influência do intervalo entre cortes sobre a produção de biomassa de duas espécies de capim limão Influence of the interval between cuts on biomass yield of two lemon grass species

    Directory of Open Access Journals (Sweden)

    André May

    2008-09-01

    Full Text Available Foi estudada a influência do intervalo entre cortes na produção de massa seca da parte aérea de duas espécies de capim limão. O experimento foi realizado no Instituto Agronômico, em Campinas-SP, 04 de junho/05 a 28 de agosto/06. O delineamento experimental utilizado foi em blocos ao acaso, com três repetições, com os tratamentos em esquema fatorial 2 x 4, sendo duas espécies (C. citratus e C. flexuosus e quatro intervalos entre cortes (40; 60; 80 e 100 dias. Para C. flexuosus, maiores intervalos entre cortes proporcionaram maior massa seca acumulada ao longo do ciclo de cultivo, partindo de 329,04 para 704,16 g planta-1 de massa seca acumulada da parte aérea, para intervalos entre cortes de 40 e 100 dias, respectivamente. A espécie C. citratus apresentou resposta linear decrescente da massa seca acumulada da parte aérea quanto maior o intervalo entre cortes utilizado, produzindo 238,68 g planta-1 utilizando intervalo entre cortes de 40 dias.The aim of this study was to analyze the influence of the interval between cuts on the dry mass yield of the aerial part of two lemon grass species. The experiment was conducted at Agronomical Institute (IAC, in Campinas - SP, from June 4th, 2005 through August 28th, 2006. The experiment was carried out in a completely randomized block design, with three replications, and the treatments in a 2 x 4 factorial design, corresponding two species (C. citratus and C. flexuosus and four intervals between cuts (40; 60; 80 and 100 days. For C. flexuosus, longer intervals between cuts generated more dry mass accumulated throughout the cultivation cycle, beginning on 329,04 to 704,16 g plant-1 of accumulated dry mass of the aerial part, for intervals between cuts of 40 and 100 days, respectively. The C. citratus species showed a decrease in its linear response for the accumulated dry mass of the aerial part the longer the interval between cuts was, yielding 238,68 g plant-1 for a 40 day interval between

  20. Determinação da qualidade microbiológica e físico-química de chás de Cymbopogon citratus (D.C Stapf (capim-limão = Evaluation of the microbiological and physical-chemical qualities of lemongrass tea

    Directory of Open Access Journals (Sweden)

    Eliane Carneiro Gomes

    2008-01-01

    Full Text Available Em função do grande volume de produção e comercialização do capim-limão, estima-se que uma contaminação microbiológica deste produto possa representar importante risco para a saúde pública. Esta pesquisa visou avaliar marcas de chá de capimlimão, em relação às qualidades microbiológica e físico-química, tendo como base alegislação brasileira do Ministério da Saúde. Nenhuma das amostras apresentou Salmonella sp., porém em 50% delas, houve presença de coliformes a 35ºC. Em três amostras, evidenciaram-se coliformes a 45ºC, com presença de Escherichia coli em uma destas. 81,25%das amostras apresentaram bolores e leveduras, porém sem relação direta com os teores de umidade observados. Dentre os fungos presentes, identificou-se Aspergillus niger, no entanto sem produção de aflatoxinas. Todos infusos analisados negativaram a contaminação evidenciada nos testes com o produto seco. Os resultados indicaram possíveis falhas nos procedimentos pós-colheita e de comercialização. A implementação do Sistema APPCC (HACCP poderia substancialmente minimizar esta contaminação.Considering the great volume of lemongrass production andcommercialization, it is estimated that a potential microbiological contamination of this product could represent an important hazard to public health. This study was performed to evaluate different brands of lemongrass tea, regarding their microbiological and physicalchemical quality, based on the legislation of the Brazilian Health Ministry. No traces of Salmonella sp. were found, but in 50% of samples, the presence of coliforms was detected at 35ºC. Three samples presented coliforms at 45ºC, with Escherichia coli found in one of them. 81.25% of samples presented molds and yeasts. Among the fungi present, Aspergillus niger was identified, but aflatoxins were absent. None of the infusions analyzed presented the contamination evidenced in the dry product. The results obtained may be

  1. MAKNA GURU DALAM KONSEP TA’LIM, TARBIYYAH DAN TAZKIYYAH

    Directory of Open Access Journals (Sweden)

    Wawan Setiawan

    2016-02-01

    Full Text Available This paper intends to analyze concepts associated to the duties and functions of a teacher such as, tarbiyyah, and tazkiyyah in al-Quran based on philosophical and pedagogical. There are a number of new challenges to interpret these concepts in order contextual with the demands and needs of the times. The results showed that the study groups is not just imparting knowledge and skills, but also emphasize the empowering sense. Empowering mind will enable students to develop skills in solving everyday problems. Empowering mind can deliver students aware of God's wisdom. Orientation tarbiyyah intends to develop the potential of physical, psychological, and affective concerns such as moods, feelings, self-image, motivation, mental toughness as a characteristic ribbiyyûn. Tazkiyyah aims to develop heart as a place of faith, and avoiding polytheism. The activity was done by planting a religious duty to practice the habit of the practice of worship with the appreciation will be God's wisdom.

  2. Determinação da qualidade microbiológica e físico-química de chás de Cymbopogon citratus (D.C Stapf (capim-limão - DOI: 10.4025/actascihealthsci.v30i1.4396 Evaluation of the microbiological and physical-chemical qualities of lemongrass tea - DOI: 10.4025/actascihealthsci.v30i1.4396

    Directory of Open Access Journals (Sweden)

    Raquel Rejane Bonato Negrelle

    2008-07-01

    Full Text Available Em função do grande volume de produção e comercialização do capim-limão, estima-se que uma contaminação microbiológica deste produto possa representar importante risco para a saúde pública. Esta pesquisa visou avaliar marcas de chá de capim-limão, em relação às qualidades microbiológica e físico-química, tendo como base a legislação brasileira do Ministério da Saúde. Nenhuma das amostras apresentou Salmonella sp, porém em 50% delas, houve presença de coliformes a 35ºC. Em três amostras, evidenciaram-se coliformes a 45ºC, com presença de Escherichia coli em uma destas. 81,25% das amostras apresentaram bolores e leveduras, porém sem relação direta com os teores de umidade observados. Dentre os fungos presentes, identificou-se Aspergillus niger, no entanto sem produção de aflatoxinas. Todos infusos analisados negativaram a contaminação evidenciada nos testes com o produto seco. Os resultados indicaram possíveis falhas nos procedimentos pós-colheita e de comercialização. A implementação do Sistema APPCC (HACCP poderia substancialmente minimizar esta contaminação.Considering the great volume of lemongrass production and commercialization, it is estimated that a potential microbiological contamination of this product could represent an important hazard to public health. This study was performed to evaluate different brands of lemongrass tea, regarding their microbiological and physical-chemical quality, based on the legislation of the Brazilian Health Ministry. No traces of Salmonella sp were found, but in 50% of samples, the presence of coliforms was detected at 35ºC. Three samples presented coliforms at 45ºC, with Escherichia coli found in one of them. 81.25% of samples presented molds and yeasts. Among the fungi present, Aspergillus niger was identified, but aflatoxins were absent. None of the infusions analyzed presented the contamination evidenced in the dry product. The results obtained may be

  3. Page 1 Lemma 4.2. Let s.lim, ... An = A and S.lim Quantum ...

    Indian Academy of Sciences (India)

    topology. Given a dynamical semigroup t we define the predual semigroup a = {a, t > 0} on 37 as tr(x0,00)) = tr{pt,(x)) (20) wherever t > 0, pe?, xe3(3%). Note that the family a is uniquely determined if (20) holds for p:= |f > < g|, f, ge.9% o. It is also evident that a is a strongly continuous one parameter semigroup in the Banach ...

  4. "Como se tivesse ganho na loteria": o significado da reabilitação vocal na visão de um paciente laringectomizado "Como si hubiese ganado la lotería": el significado de la rehabilitación de la voz, bajo la visión de un paciente laringectomizado "As if i had won in the lottery": the meaning of voice rehabilitation in the view of a laryngectomized patient

    Directory of Open Access Journals (Sweden)

    Patrícia Gonçalvez Custódio Flávio

    1997-07-01

    Full Text Available Esse trabalho consistiu no estudo de caso de um paciente laringectomizado, com o objetivo de "descrever o significado da reabilitação vocal por um paciente laringectomizado". A análise dos dados foi realizada pela identificação de categorias de significado. O significado que emergiu foi "Como se tivesse ganho na loteria". Com essa frase o paciente desvelou a complexidade do processo, fornecendo-nos a apreensão dessa etapa da sua reabilitação.Esta investigación consiste en un estudio de caso de un paciente con traqueostomía cuyo objetivo fue "describir el significado del retorno de la capacidad de emisión de la voz". El análisis de los datos fue realizado por la identificación de categorías. El significado emergente que se verificó fue: "como si hubiera ganado la lotería". A través de esa frase, manifestada por el paciente, pudimos comprender la complejidad del proceso.This is a case study of a laryngectomized patient with the objective of "describing the meaning of voice rehabilitation". Data analysis was based on the search for categories of meaning. The central theme that emerged from the present study was "As if I had won in the lottery". With these words the patient revealed the complexity of this process.

  5. Qualidade de produtos a base de plantas medicinais comercializados no Brasil: castanha-da-índia (Aesculus hippocastanum L., capim-limão (Cymbopogon citratus (DC. Stapf e centela (Centella asiatica (L. Urban Quality of products made from medicinal plants commercialized in Brazil: horsechestnut (Aesculus hippocastanum L., lemongrass (Cymbopogon citratus (DC. Stapf, and gotu kola (Centella asiatica (L. Urban

    Directory of Open Access Journals (Sweden)

    Joabe Gomes de Melo

    2007-03-01

    Full Text Available Com o objetivo de avaliar a qualidade de produtos a base de plantas medicinais, analisou-se dez amostras de castanha-da-índia, onze de capim-limão e seis de centela, comercializadas em farmácias da cidade do Recife, provenientes de indústrias de várias partes do país. Analisamos as informações técnico-científicas nos rótulos e/ou bulas de acordo com as exigências e obrigatoriedades da legislação brasileira (RDC n. 140 de 29/05/2003 e na RDC n. 102 de 30/11/2000, e embasamento da literatura científica. Também avaliou-se as características organolépticas, a autenticidade e a pureza dos produtos. Constatou-se ausência das informações obrigatórias em 92,59% das amostras. Dentre os termos vedados, foi comum a sugestão da inexistência de efeitos colaterais ou adversos. Quanto as indicações terapêuticas não se observou padronização técnica dos termos nem comprovação científica para algumas das atividades atribuídas pelos fabricantes. Todas as amostras foram consideradas autênticas com base nos testes fitoquímicos e farmacobotânicos. Na análise da pureza 59,26% das amostras foram reprovadas, devido principalmente ao elevado teor de umidade e cinzas totais. Constata-se que além dos produtos comercializados carecerem de informações e qualidade adequadas, há necessidade urgente de uma fiscalização efetiva por parte dos órgãos competentes.Aiming to evaluate the quality of products made from medicinal plants, there were analyzed ten samples of horsechestnut, eleven samples of lemongrass, and six samples of gotu kola commercialized in pharmacies from the city of Recife (Pernambuco, Brazil, coming from industries of several parts of the country. We analyzed the technical-scientific information on the labels and/or directions according to the requirements and obligations of Brazilian law (laws "RDC 140 of 29/05/2003" and "RDC 102 of 30/11/2000" and to scientific literature embasement. The products' organoleptic

  6. Plant growth and phosphorus uptake in mycorrhizal rangpur lime seedlings under different levels of phosphorus Crescimento e absorção de fósforo por plântulas de limão 'Cravo' micorrizadas sob diferentes níveis de fósforo

    Directory of Open Access Journals (Sweden)

    Marco Antonio Nogueira

    2006-01-01

    Full Text Available The objective of this work was to evaluate the response of rangpur lime (Citrus limonia to arbuscular mycorrhiza (Glomus intraradices, under P levels ranging from low to excessive. Plants were grown in three levels of soluble P (25, 200 and 1,000 mg kg-1, either inoculated with Glomus intraradices or left noninoculated, evaluated at 30, 60, 90, 120 and 150 days after transplanting (DAT. Total dry weight, shoot P concentration and specific P uptake by roots increased in mycorrhizal plants with the doses of 25 and 200 mg kg-1 P at 90 DAT. With 1,000 mg kg-1 P, mycorrhizal plants had a transient growth depression at 90 and 120 DAT, and nonmycorrhizal effects on P uptake at any harvesting period. Root colonization and total external mycelium correlated positively with shoot P concentration and total dry weight at the two lowest P levels. Although the highest P level decreased root colonization, it did not affect total external mycelium to the same extent. As a result, a P availability imbalance affected negatively the mycorrhizal symbiosis and, consequently, the plant growth.O objetivo deste trabalho foi avaliar a resposta do limão 'Cravo' (Citrus limonia à micorriza arbuscular (Glomus intraradices, com variações de níveis de P de baixo a excessivo. As plantas foram cultivadas em três níveis de P solúvel (25, 200 e 1.000 mg kg-1, com inoculação de Glomus intraradices ou sem inoculação, e avaliadas aos 30, 60, 90, 120 e 150 dias depois do transplantio (DAT. A biomassa seca total, a concentração de P na parte aérea, e a absorção específica de P pelas raízes aumentaram nas plantas micorrizadas nas doses de 25 e 200 mg kg-1 de P aos 90 DAT. Na dose de 1.000 mg kg-1 de P, houve depressão transiente de crescimento nas plantas micorrizadas, aos 90 e 120 DAT, e não houve efeito micorrízico sobre a absorção de P em qualquer época de colheita. A colonização radicular e o micélio externo total correlacionaram-se positivamente com a

  7. "A campaign won as a public issue will stay won": using cartoons and comics to fight national health care reform, 1940s and beyond.

    Science.gov (United States)

    Knoblauch, Heidi Katherine

    2014-02-01

    On March 23, 2010, President Barack Obama signed the Patient Protection and Affordable Care Act (ACA) into law. As it went through Congress, the legislation faced forceful resistance. Individuals and organizations opposing the ACA circulated propaganda that varied from photographs of fresh graves or coffins with the caption "Result of ObamaCare" to portrayals of President Obama as the Joker from the Batman movies, captioned with the single word "socialism." The arguments embedded in these images have striking parallels to cartoons circulated by physicians to their patients in earlier fights against national health care. Examining cartoons used in the formative health care reform debates of the 1940s provides a means for tracing the lineage of emotional arguments employed against health care reform.

  8. TA'LIM AL-LUGHAH 'ABR AL-TSAQAFAT WA TATHBIQUHU FI TA'LIM AL-LUGHAH AL-'ARABIYAH FI INDONESIA

    Directory of Open Access Journals (Sweden)

    Nasaruddin Nasaruddin

    2015-12-01

    Full Text Available This article examines the close relationship that exists between language and culture which  reflected in that language is a pot of culture and culture is a frame of language usage. It follows from this relationship that language learning is the linguistic and cultural process, or what so-called teaching language across cultures. This cultural teaching of language is based on three theories first of which is “Contrastive Analysis”, “Learning The Language Is A Cultural Learning”, and “Cultural Awareness In Foreign Language Teaching And Learning”. Based on these three theories this article tries to put down a cultural pattern for the teaching of Arabic for Indonesian learners which has cultural goals and content.  It aims at overcoming linguistic and cultural problems suffered by the Indonesians when learning the Arabic, especially their difficulty in understanding Arabic elements that are different from what in their language, and their difficulty  in using Arabic in certain situations properly.DOI: 10.15408/a.v2i2.2141

  9. From fission to fusion: A perspective on the research that won the ...

    Indian Academy of Sciences (India)

    The Nobel Prize in Physiology or Medicine 2013 was awarded to Drs Randy Schekman, James E Rothman and Thomas C Südhof for their 'discoveries of machinery regulating vesicle traffic, a major transport system in our cells'. Dr Randy Schekman and his colleagues discovered a number of genes required for vesicle ...

  10. How physics confronts reality Einstein was correct, but Bohr won the game

    CERN Document Server

    Newton, Roger G

    2009-01-01

    This book recalls, for nonscientific readers, the history of quantum mechanics, the main points of its interpretation, and Einstein's objections to it, together with the responses engendered by his arguments. Most popular discussions on the strange aspects of quantum mechanics ignore the fundamental fact that Einstein was correct in his insistence that the theory does not directly describe reality. While that fact does not remove the theory's counterintuitive features, it casts them in a different light.Context is provided by following the history of two central aspects of physics: the elucida

  11. If you don't ask (about memory), they probably won't tell

    DEFF Research Database (Denmark)

    Waldorff, Frans Boch; Rishoj, Susanne; Waldemar, Gunhild

    2008-01-01

    for impaired memory was a lower quality-of-life score: scores on the EuroQoL-5D-VAS of 0 to 49 and 50-74 points both correlated with memory complaints (odds ratios=4.8 and 4.1, respectively). CONCLUSIONS: Memory impairment is a common complaint among elderly patients in general practice, but many patients...

  12. Apocalypse deferred a new accelerator at Brookhaven won't destroy the world after all

    CERN Multimedia

    Alpert, M

    1999-01-01

    A group of physicists have reported that it is effectively impossible to form 'Strangelets' in an ion collider since they can only be produced under conditions of extremely high pressure and low temperature. As a result of this report, officials aim to begin the first collisions at RHIC at the end of this year (1 page).

  13. Why they won't save us: Political dispositions in the conflicts of superheroes

    Directory of Open Access Journals (Sweden)

    Woody Evans

    2014-09-01

    Full Text Available Comic book superheroes tend to be conservative and their opponents progressive. Here I explore the reasons for heroic conservatism, review recent disruptions to the trend, and consider what superhuman politics can tell us about our own transhuman and science fictional conditions.

  14. It Won't Be Easy, but You Must Learn the Arcane New Rules of Arbitrage.

    Science.gov (United States)

    Anderson, David; Brennan, William

    1988-01-01

    With passage of the Tax Reform Act of 1986, school systems became liable to the federal government for any profits earned on tax-exempt bonds. Understanding the requirements is essential for any board facing significant capital financing. Outlines requirements, exceptions to the rule, penalties, costs, and debt planning. (MLF)

  15. That I won't translate! Experiences of a family medical interpreter in a multicultural environment.

    Science.gov (United States)

    Seidelman, Rhona D; Bachner, Yaacov G

    2010-01-01

    Family members used as patients' interpreters are a common occurrence in the medical environments of multicultural societies. It is recognized that the use of the family-member interpreter may have some benefits. However, studies show that this option also has substantial disadvantages and therefore suggest that the use of professional medical interpreters is the preferable option for effective quality care. The purpose of the current study is to present the narrative of a family-member interpreter in Israel, a diverse immigrant society. While numerous studies have been done on the challenges in the doctor-interpreter-patient medical encounter, these studies tend to focus on the experiences of the physicians or the patients, and the perspective of the interpreter is often sidelined. After discussing the various interpreting options, we suggest that the perspective of the family-member interpreter strengthens assertions that professional interpretation is the best option for multilingual medical environments. 2010 Mount Sinai School of Medicine.

  16. Why won't they listen: Negotiating the technological and social context for science teaching

    Science.gov (United States)

    Liuzzo, Anna M.

    The purpose of this study was to gather information to identify the obstacles and the impact an implementation of technology had in a middle school science classroom. This study explored a teaching environment where the teacher planned on using a variety of technology tools including laptops, probeware, hardware and software to promote scientific study. This study took place in two phases consisting of three consecutive years. In phase one the teacher reported great success. In phase two a shift in the school implementation created a significant impact on the learning taking place. This study identified the obstacles faced by a teacher providing an environment that combined her pedagogy with technology implementation. This teacher's pedagogy included research-based practices such a authentic problem-based learning, scientific inquiry, conceptual understanding of problem solving, connections to real-life situations and the use of metacognition in her practice. This study looked to determined if this implementation had an effect on student engagement and achievement; how the nature of technical and professional development impacted the implementation; and the barriers that were faced in creating a student-centered, technology rich approach to science. This qualitative study was conducted meeting the criteria of a case study of one teacher. The participant teacher's accounts of events through interviews were the primary source of data. In addition, multiple sources of information were also gathered. These included the teacher's reflective journal, student interviews, student focus groups, student artifacts, classroom observations, field notes, e-mail correspondences and students' test scores. This study proposes to contribute to the growing research evidence of implementation in the classroom and to identify specific obstacles that hinder success. The current state of education is calling for reform.

  17. Structural Breaks and Long Memory Property in Korean Won Exchange Rates: Adaptive FIGARCH Model

    Directory of Open Access Journals (Sweden)

    Young Wook Han

    2011-06-01

    Full Text Available This paper explores the issue of structural breaks and long memory property in the conditional variance process of the Korean exchange rates. To analyze the above in detail, this paper examines the dynamics of the structural breaks and the long memory in the conditional variance process of the Korean exchange returns by using the daily KRW-USD and KRW-JPY exchange rates for the period from 2000 through 2007. In particular, this paper employs the Adaptive FIGARCH model of Baillie and Morana (2009 which account for the structural breaks and the long memory property together. This paper also finds that the new Adaptive FIGARCH model outperforms the usual FIGARCH model of Baillie et al. (1996 when the structural breaks are present and that the long memory property in the conditional variance process of the Korean exchange returns is significantly reduced after the structural breaks are accounted for. Thus, these results suggest that the upward biased long memory property observed in the conditional variance process of the Korean exchange returns could partially have been imparted as a result of neglecting the structural breaks.

  18. Children Who Won't Go to School (Separation Anxiety). Facts for Families. Number 7

    Science.gov (United States)

    American Academy of Child & Adolescent Psychiatry (NJ1), 2011

    2011-01-01

    Going to school is usually an exciting and enjoyable event for young children. However, for some it can cause intense fear or panic. Parents should be concerned if their child regularly complains about feeling sick or often asks to stay home from school with minor physical complaints. Not wanting to go to school may occur at any time, but is most…

  19. Requirements change: Fears dictate the must haves, desires the won't haves

    NARCIS (Netherlands)

    Hoorn, J.F.; Konijn, E.A.; Vliet, H.; van der Veer, G.

    2007-01-01

    We attempt to contribute to a general theory of requirements change from a goal-oriented and viewpoints-driven angle. To practitioners, this knowledge is relevant to anticipate changes in certain types of requirements, which may shorten the project's timeline, reduce costs, and increase product

  20. Requirements change: Fears dictate the must have: desires the won't have.

    NARCIS (Netherlands)

    Hoorn, J.F.; Konijn, E.A.; Van Vliet, H.; Van der Veer, G.

    2006-01-01

    We attempt to contribute to a general theory of requirements change from a goal-oriented and viewpoints-driven angle. To practitioners, this knowledge is relevant to anticipate changes in certain types of requirements, which may shorten the project's timeline, reduce costs, and increase product

  1. Requirements change: Fear dictates the must haves, desires the won't haves

    NARCIS (Netherlands)

    Hoorn, J.F.; Konijn, E.A.; van Vliet, H.; van der Veer, G.C.

    2007-01-01

    We attempt to contribute to a general theory of requirements change from a goal-oriented and viewpoints-driven angle. To practitioners, this knowledge is relevant to anticipate changes in certain types of requirements, which may shorten the project's timeline, reduce costs, and increase product

  2. Talk Alone Won't Close the 30-Million Word Gap

    Science.gov (United States)

    Wasik, Barbara A.; Hindman, Annemarie H.

    2015-01-01

    Interventions that affect children's vocabulary development focus on the quality of language as well as quantity. Children need opportunities to talk, use vocabulary words, and respond to adults' questions. Adults need to create opportunities to talk, provide quality feedback on children's language, and use a lot of new vocabulary repeatedly in…

  3. Stopping the Brain Drain of Skilled Veteran Teachers: Retaining and Valuing Their Hard-Won Experience

    Science.gov (United States)

    Fibkins, William L.

    2011-01-01

    Veteran educators are being encouraged to take early retirement in order to create jobs for less-experienced, lower-paid novices. Veteran educators are not alone: early retirement promotions have become the norm for aging workers in America. Consequently, there is a brain-drain of skilled workers at the national, state, and local levels. The early…

  4. AP Interview : Estonian leader denies seeking Russia's breakup, says Moscow won't accept past

    Index Scriptorium Estoniae

    2008-01-01

    President Toomas Hendrik Ilvese esinemisest soome-ugri rahvaste maailmakongressil Hantõ-Mansiiskis. Eesti president lükkab ümber Vene riigiduuma väliskomisjoni esimehe Konstantin Kossatshovi süüdistuse, et tema kõnest võis välja lugeda toetusavalduse soome-ugri rahvaste iseseisvusele. Vabariigi President töövisiidil Venemaal 27.-30.06.2008

  5. The Forgotten Airman - Major General Oliver P. Echols and How He Won WWII

    Science.gov (United States)

    2012-06-01

    aircraft are in combat with the enemy in the Aleutians, New Caledonia, New Guinea, Australia, China, India, Egypt, England, and Iceland . In every...Paget’s disease , a chronic ailment that weakens bones. After his condition did not improve during his hospital stay, on 23 December 1946, an Army...Department of the Air Force, Washington, DC, 17 Nov 1960 , 168.7252-12 Oliver P. Echols Death 15 May 1954, Volume XI, IRIS No. 01082422, in Echols

  6. You Won't Get Me: Therapist Responses to Patient Impression Management Tactics.

    Science.gov (United States)

    Frühauf, Sarah; Figlioli, Patrick; Caspar, Franz

    2017-03-01

    In psychotherapy, therapist and patient influence each other constantly. We aimed to investigate how therapists respond to patient impression management and influence tactics. For 60 videotaped intake interviews, judges rated therapist responses to patient tactics as neutral, desired, or undesired from the patient perspective. Judges rated the therapist responses in 57% as neutral, in 40% as desired, and in 2% as undesired by the patients. The proportions of response outcomes varied across tactics. Therapist responses were unrelated to therapist and patient sex. Therapist experience was related to their responses to the tactic Supplication. Overall, some patient tactics seem to be more challenging for therapists than others. Awareness of such response tendencies can help therapists prepare their reactions to certain patient impression management and influence tactics. Implications for training and research are presented.

  7. What Is Mathematics and Why Won't It Go Away?

    Science.gov (United States)

    Colley, Susan Jane

    2011-01-01

    In this article, the author reports on a seminar for first-year college students that weaves mathematical proof and problem-solving together with discussions of cultural, philosophical, and aesthetic issues surrounding mathematics. The author's goal is for students to learn some mathematics, and--just as important--to think about the nature of…

  8. Why Evil won't go Away

    DEFF Research Database (Denmark)

    Runehov, Anne Leona Cesarine

    2008-01-01

    experiences per se, religious interpretations, religiosity, theology and religious and non-religious ideologies. It will be seen that religion is a very complex issue. It will also become clear that evil related to religions does not differ from evil related to non-religious ideologies. Dawkins' statement......The aim of the present article is to critically analyse Richard Dawkins' and Sam Harris' view on the relationship between religion and evil and to argue that the problem of evil is far more complex than they want us to believe. I will argue that attention needs to be paid to different types of evil......, namely, (1) natural evil; (2) pure accidental moral evil; (3) belief-based accidental moral evil; (4) active but non-responsible moral evil and (5) active and responsible moral evil. Furthermore, I will argue that it is important to take into account the relation between religion, worldviews, religious...

  9. Youth Work and Ethics: Why the "Professional Turn" Won't Do

    Science.gov (United States)

    Davies, Richard

    2016-01-01

    Youth work is deemed to require a distinctive commitment to ethical behaviour from the adults involved. This is expressed in the requirements for the initial education of workers, in the subject benchmarks and national expectations for youth workers. A significant influence in this debate is Howard Sercombe. Sercombe seeks a substantive framework…

  10. On-the-job training won't cut it any more, experts say.

    Science.gov (United States)

    2013-07-01

    Today's case managers need far more than on-the-job training to understand the complexities of the job and all of the tasks they must do on a daily basis. The length and content of the training must be geared to individual case managers and take into account their knowledge, skill set and experience. New case managers should be able to pass competencies and should meet with the case manager director and the person doing the training at the end of the week to discuss how the training is going. Hospital case managers must develop their own case management training programs that are based on hospital procedures and policies, specific job descriptions, and goals of the department, some experts say. In many cases, rather than hiring an experienced case manager who may not fit well into your department, it's better to hire someone with the characteristics you are looking for and teach him or her case management.

  11. Who decides who has won the bet? Total and Anthropogenic Warming Indices

    Science.gov (United States)

    Haustein, K.; Allen, M. R.; Otto, F. E. L.; Schmidt, A.; Frame, D. J.; Forster, P.; Matthews, D.

    2016-12-01

    An extension of the idea of betting markets as a means of revealing opinions about future climate are climate policies indexed to geophysical indicators: for example, to ensure net zero global carbon dioxide emissions by the time anthropogenic warming reaches 1.5 degrees above pre-industrial, given about 1 degree of warming already, emissions must fall, on average, by 20% of their current value for every tenth of a degree of anthropogenic warming from now on. In principle, policies conditioned on some measure of attributable warming are robust to uncertainty in the global climate response: the risk of a higher or lower response than expected is borne by those affected by climate change mitigation policy rather than those affected by climate change impacts, as is the case with emission targets for specific years based on "current understanding" of the response. To implement any indexed policy, or to agree payout terms for any bet on future climate, requires consensus on the definition of the index: how is it calculated, and who is responsible for releasing it? The global mean surface temperature of the current decade relative to pre-industrial may vary by 0.1 degree or more depending on precisely what is measured, what is defined as pre-industrial, and the treatment of regions with sparse data coverage in earlier years. Indices defined using different conventions, however, are all expected to evolve very similarly over the coming decades, so agreeing on a conservative, traceable index such as HadCRUT is more important than debating the "true" global temperature. A more important question is whether indexed policies and betting markets should focus on total warming, including natural and anthropogenic drivers and internal variability, or an Anthropogenic Warming Index (AWI) representing an unbiased estimate of warming attributable to human influence to date. We propose a simple AWI based solely on observed temperatures and global natural and anthropogenic forcing estimates. It is much less volatile than total observed warming, which might discourage participation in betting markets, but would be a substantial advantage for indexed policies. It is also much more relevant to the UNFCCC goal of limiting anthropogenic warming to "well below" 2 degrees. The 2016 value for the AWI will be announced at AGU.

  12. The Libyan Model and Strategy: Why it Won't Work in Syria

    Directory of Open Access Journals (Sweden)

    Lance Kildron

    2012-01-01

    Full Text Available Operation Unified Protector (Libya, 2011 is the latest example of how a limited-means military intervention in a humanitarian crisis can stop the murder of innocent civilians. Proponents of intervention in the name of "responsibility to protect" (R2P have stated that the air campaign strategy used in Libya could be the model for future U.S. military engagement overseas. This begs the question of when the United States should insert itself militarily into a humanitarian crisis. For instance, Syria is a potential candidate for military intervention. The following article takes the reasons for military intervention in Libya, as explained by President Obama in his address to the nation in March 2011, and creates criteria for future humanitarian military intervention. By defining and applying these criteria to a humanitarian crisis such as Syria, it is revealed that the Libya campaign model does not fit Syria now, nor does the model provide a panacea for all future humanitarian crises. While the tenets of the Libya strategy could apply to other humanitarian crises, proponents for military intervention must meet the criteria laid out in this article, or the United States may find itself committed to a futile air campaign unable to achieve the nation's strategic objectives.

  13. Simplified Data Envelopment Analysis: What Country Won the Olympics, and How about our CO2 Emissions?

    Directory of Open Access Journals (Sweden)

    Alexander Vaninsky

    2013-07-01

    Full Text Available This paper introduces a simplified version of Data Envelopment Analysis - a conventional approach to evaluating the performance and ranking of competitive objects characterized by two groups of factors acting in opposite directions: inputs and outputs. Examples of DEA applications discussed in this paper include the London 2012 Olympic Games and the dynamics of the United States’ environmental performance. In the first example, we find a team winner and rank the teams; in the second, we analyze the dynamics of CO2 emissions adjusted to the gross domestic product, population, and energy consumption. Adding a virtual Perfect Object – one having the greatest outputs and smallest inputs - we greatly simplify the DEA computational procedure by eliminating the Linear Programming algorithm. Simplicity of computations makes the suggested approach attractive for educational purposes, in particular, for use in Quantitative Reasoning courses.

  14. Which Improvised Tourniquet Windlasses Work Well and Which Ones Won't?

    Science.gov (United States)

    Kragh, John F; Wallum, Timothy E; Aden, James K; Dubick, Michael A; Baer, David G

    2015-09-01

    Improvised tourniquets in first aid are recommended when no scientifically designed tourniquet is available. Windlasses for mechanical advantage can be a stick or pencil and can be used singly or multiply in tightening a tourniquet band, but currently there is an absence of empiric knowledge of how well such windlasses work. The purpose of the present study was to determine the performance of improvised tourniquets in their use by the type and number of windlasses to improve tourniquet practice. A simulated Leg Tourniquet Trainer was used as a manikin thigh to test the effectiveness of improvised tourniquets of a band-and-windlass design. Two users made 20 tests each with 3 types of windlasses. Tests started with 1 representative of a given type (eg, 1 pencil), then continued with increasing numbers of each windlass type until the user reached 100% effectiveness as determined by cessation of simulated blood flow. Windlass types included chopsticks, pencils, and craft sticks. Effectiveness percentages in stopping bleeding were associated inversely with breakage percentages. Pulse stoppage percentages were associated inversely with breakage. The windlass turn numbers, time to stop bleeding, the number of windlasses, and the under-tourniquet pressure were associated inversely with breakage. The windlass type was associated with breakage; at 2 windlasses, only chopsticks were without breakage. Of those windlass types that broke, 20.7% were chopsticks, 26.1% were pencils, and 53.2% were craft sticks. A pair of chopsticks as an improvised tourniquet windlass worked better than pencils or craft sticks. Published by Elsevier Inc.

  15. Diversity in academic medicine no. 2 history of battles lost and won.

    Science.gov (United States)

    Strelnick, A Hal; Lee-Rey, Elizabeth; Nivet, Marc; Soto-Greene, Maria L

    2008-12-01

    Spurred by its rapidly changing demographics, the United States is striving to reduce and eliminate racial and ethnic health disparities. To do so, it must overcome the legacy of individual, institutional, and structural racism and resolve conflicts in related political and social ideologies. This has moved the struggle over diversity in the health professions outside the laboratories and ivy-covered walls of academic medicine into the halls of Congress and chambers of the US Supreme Court. Although equal employment opportunity and affirmative action programs began as legal remedies for distinct histories of legally sanctioned racial and gender discrimination, they also became effective means for increasing the representation of underrepresented minorities in higher education and the health professions. Beginning in the 1970s and continuing today, legal challenges to measures for realizing equal opportunity and leveling the playing field have reached the US Supreme Court and state-wide ballot initiatives. These historical challenges and successes are the subject of this article. Although the history is not exhaustive, it aims to provide an important context for the struggles of advocates to improve the representation of underrepresented minorities in medicine and reduce racial and ethnic health disparities.

  16. Can Compute, Won't Compute: Women's Participation in the Culture of Computing.

    Science.gov (United States)

    Wilson, Fiona

    2003-01-01

    Surveys of 130 psychology students and 52 computer science students (20 of the latter were interviewed) indicated that more males read computer magazines and were confident in computer use. Many did not perceive an equity problem. Men seemed to feel the equity situation is improving. Some felt that women do not enjoy computing as much as men and…

  17. Malaysia family-planning centers strive to maintain gains won in 15-year period.

    Science.gov (United States)

    Roemer, R

    1968-09-12

    Family planning in Malaysia is discussed. Family planning began in Malaysia about 15 years ago through the efforts of voluntary family Planning Associations in the various Malay states. In 1966 the Malaysian Parliament passed the National Family Planning Act setting up the National FAmily Planning Board to formulate policies and methods for the promotion and spread of family planning knowledge and practice on the grounds of health of mothers and children and welfare of the family. In 1967, the board set a target of 40,000 new acceptors of family planning and 90% of the target was reached. This represents 3% of the child-bearing married women aged 15-49. The target for 1968 of 65,000 new acceptors is being achieved. A survey of acceptors is to be carried out from December 1968 to April 1969 to ascertain how many women who accepted family planning continue to practice it. Malaysia's crude birth rate declined from 46.2 in 1957 to 37.3 in 1966 before the government program was instituted. Abortion attempts have been frequent. The main method of contraception used is oral contraceptives. According to a 1957 survey, 31% of the married women in the metropolitan areas and 2% of rural women were using contraception. Presently, in Malaysia there is a need to: 1) train personnel to provide services, 2) inform and motivate families to accept family planning, 3) continue a broad educational program, 4) reform Malaysia's antiquated abortion law, and 5) integrate family planning services more fully into the general health services of the country.

  18. Middle management terminations: things HR probably won't tell you.

    Science.gov (United States)

    Snuttjer, Denise

    2002-01-01

    Being a manager or director, you may have received training for how to prepare your subordinates for layoffs or terminations. But, would you be prepared if the employee being terminated were you? Termination practice rules for a manager are very different from the rules required for a staff employee. There are many things you can do ahead of time to help you respond to being terminated: Keep copies of important information at home. If you are terminated, you may be asked to go home without going back to your office for an extended time. If you are given time to consider options, you will do that from your home. Keep a copy of an updated resume on file. If you do not have internet, email or fax capabilities at your home, get them. Many companies offer ongoing education as a benefit option. Take advantage of it. Ongoing education will keep as many doors open as possible as you look for another job. Keep copies of summary plan descriptions of your benefits, especially your retirement plan. To be prepared for change, you should know the "street value" of the benefits that you require. Make sure you have an attorney you can trust. Find out how many years of experience in employment law he or she has. Also, make sure your current attorney would not have a conflict of interest in handling your case against your company. There are no set laws for severance benefits, but your company may have a policy based on the years of service and the level of management. Upon receipt of a severance agreement, you should have it reviewed by your attorney. You will be given a time frame within which to sign or to respond to the proposal. The company will offer the least amount they feel you will accept, and it is appropriate to negotiate the severance agreement. Termination is not the time to make amends for hard feelings that may have been created in the workplace. The advice, "Always be a little nicer than you have to be," will bear fruit when you are looking for a new job. Your reputation will precede you. Remember that your job does not define who you are. You are defined by the endless decisions you have made, actions you have taken, the relationships you have built and the values you have portrayed. Your job description may change, but you will not. If you have done your job in a way that you can be proud of, then you have been successful. Change can be difficult, but change is always easier if you are prepared. Job changes are not always within your control, but preparing to accept the change is something that managers can control.

  19. Have All Won and Must All Have Prizes? Revisiting Luborsky et al.'s Verdict.

    Science.gov (United States)

    Beutler, Larry E.

    1991-01-01

    Sees need for research examining differences among psychotherapy treatments to use model to narrow search for variables mediating between treatment type and outcome. Asserts that tests of treatment selection models that cut across narrow theoretical differences among psychotherapies and that operationalize definitions of patient types hold promise…

  20. Intractable Headache - The Pain in Your Head that Just Won't Quit

    Science.gov (United States)

    ... when working with patients to find treatment plans. Gender, Hormones and Migraine Much of the conversation about ... walks to maximize quality time. When you’re lying in a dark room with throbbing head pain, ...

  1. Free won't : neurobiological bases of the development of intentional inhibition

    NARCIS (Netherlands)

    Schel, Margot Antoinette

    2015-01-01

    Self-control abilities are crucial for successful functioning in daily life. At the core of self-control lies the ability to intentionally inhibit one’s actions. Intentional inhibition differs from externally driven inhibition in that it is driven by an internal thought process rather than an

  2. Can Reparations for Apartheid Profi ts be Won in US Courts? | Bond ...

    African Journals Online (AJOL)

    extends the logic of international antiracism solidarity campaigning, dating back to the sanctions era. Plaintiffs' use of the Alien Tort Claims Act extends a precedent set by Holocaust victims' descendants. The US justice system's conservatism is stretched, due to plaintiff appeals in 2008 reaching even the Supreme Court.

  3. "Why won't my patients do what's good for them?" Motivational interviewing and treatment adherence.

    Science.gov (United States)

    Zuckoff, Allan

    2012-01-01

    Limited adherence to healthy habits in adults at risk of lifestyle diseases, some of whom become candidates for bariatric surgery, has been paralleled by high rates of nonadherence to postbariatric surgery behavioral recommendations. This is a specific case of the more general problem of nonadherence to medical treatment of chronic conditions. An adequate understanding of the problem of nonadherence requires an understanding of the motivational factors that influence whether persons implement healthy behavior. Motivational interviewing is an empirically supported counseling style for strengthening a person's own motivation and commitment to change. It offers a model for understanding and intervening with nonadherence to behavioral recommendations that emphasizes the role of clinician communication in both increasing and inadvertently decreasing patient motivation. A conceptual account of patient motivation for healthy change, highlighting the centrality of resolution of patient ambivalence through targeted conversation, is illustrated by thought exercises for the reader and supplemented by references to empirical data. Recommendations for changes in clinical practice to improve patient adherence to behavioral recommendations are also offered. Copyright © 2012 American Society for Metabolic and Bariatric Surgery. Published by Elsevier Inc. All rights reserved.

  4. Why the war on drugs in sport will never be won.

    Science.gov (United States)

    Smith, Aaron C T; Stewart, Bob

    2015-11-10

    Recent exposes of drug use in sports suggest that doping might be more problematic than doping-control test results reveal. A zero-tolerance (ZT) model, which aims to eliminate the use, has dominated the thinking of sport's policy makers over the last 15 years. In light of the limitations associated with ZT-based policy, we propose an alternative policy, one based on controlled use and harm reduction principles. We argue that substance control policies underpinned by harm reduction (HR) principles of social utility and public value will deliver superior social outcomes. First, a harm reduction approach better accommodates the competitive realities of sports and the impact of elite sports' emphasis on performance at all costs. Second, HR prioritises athlete welfare over sport and brand reputation. Finally, while appreciating the regulatory and risk management responsibilities of sports' governing bodies, the HR model offers greater space to the athlete's right to privacy, and right to personal autonomy.

  5. Why Won't You Do What I Want? The Informative Failures of Children and Models

    Science.gov (United States)

    Chatham, Christopher H.; Yerys, Benjamin E.; Munakata, Yuko

    2012-01-01

    Computational models are powerful tools--too powerful, according to some. We argue that the idea that models can "do anything" is wrong, and we describe how their failures have been informative. We present new work showing surprising diversity in the effects of feedback on children's task-switching, such that some children perseverate despite this…

  6. La inocuidad alimentaria en el mercado Mexicano de Limón Persa (Citrus latifolia tanaka)

    OpenAIRE

    Herbert Ruiz, Marlene

    2012-01-01

    La globalización comercial exige que los mercados mundiales de productos agroalimentarios observen prácticas de inocuidad en sus productos: libres de contaminantes químicos, biológicos y físicos. En ese contexto, México modificó el 26 de julio de 2007 la Ley Federal de Sanidad Vegetal (LFSV), la cual ahora tiene como objetivo la aplicación, verificación y certificación de los sistemas de reducción de riesgos de contaminación en la producción y empaque de vegetales. El obje...

  7. miR-9a prevents apoptosis during wing development by repressing Drosophila LIM-only

    National Research Council Canada - National Science Library

    Bejarano, Fernando; Smibert, Peter; Lai, Eric C

    2010-01-01

    .... Here, we establish that the latter phenotype is largely due to ectopic apoptosis in the dorsal wing primordium, and we could rescue wing development in the absence of this microRNA by dorsal-specific...

  8. LIM domain only-2 (LMO2 induces T-cell leukemia by two distinct pathways.

    Directory of Open Access Journals (Sweden)

    Stephen Smith

    Full Text Available The LMO2 oncogene is deregulated in the majority of human T-cell leukemia cases and in most gene therapy-induced T-cell leukemias. We made transgenic mice with enforced expression of Lmo2 in T-cells by the CD2 promoter/enhancer. These transgenic mice developed highly penetrant T-ALL by two distinct patterns of gene expression: one in which there was concordant activation of Lyl1, Hhex, and Mycn or alternatively, with Notch1 target gene activation. Most strikingly, this gene expression clustering was conserved in human Early T-cell Precursor ALL (ETP-ALL, where LMO2, HHEX, LYL1, and MYCN were most highly expressed. We discovered that HHEX is a direct transcriptional target of LMO2 consistent with its concordant gene expression. Furthermore, conditional inactivation of Hhex in CD2-Lmo2 transgenic mice markedly attenuated T-ALL development, demonstrating that Hhex is a crucial mediator of Lmo2's oncogenic function. The CD2-Lmo2 transgenic mice offer mechanistic insight into concordant oncogene expression and provide a model for the highly treatment-resistant ETP-ALL subtype.

  9. Problems in the study of the medieval heritage in the Lim valley

    Directory of Open Access Journals (Sweden)

    Popović Marko

    2005-01-01

    Full Text Available Discussing the results of archaeological investigation at two important medieval sites - remains of the monastery of St George at Mažići near Priboj and of the church at Drenova near Prijepolje - the author puts forward his critical observations that make significant revisions to the conclusions suggested by excavators. The remains of a monastery at Mažići have long ago been identified with the monastery of St George in the župa (district of Dabar known from early 13th-century records. In the 1310s a monastery of St George is referred to in association with the toponym of Orahovica. After a long gap, the monastery is referred to again several times in the 1600s until its final destruction in 1743, as St George’s at Orahovica or simply Mažić(i. The report following systematic archaeological excavations suggests the unacceptable and unfounded conclusion, with dating and interpretation that the monastery church was built in the 13th century, received additions in the 14th, and was renovated in the 16th-17th centuries when there was a hospital attached to it. Careful analysis of the structural remains and the site’s stratigraphy clearly shows that the monastery was built on the site of a medieval cemetery of a 14th-15th-century date, which means that the church and its buildings cannot be older than the 16th century. The author also argues against the assumed presence of a monastic hospital, the assumption being based upon metal artifacts misinterpreted as "medical instruments" (parchment edge trimmer, compasses, fork!!!. The author’s inference is that the ruins at Mažići are not the remains of the monastery of St George, which should be searched for elsewhere, but possibly the legacy of a 14th-century monastic establishment which was moved there from an as yet unknown location most likely about the middle of the 16th century. The site at Drenova, with remains of a church destroyed by land slide, has been known since the late 19th century when a stone block was found there bearing the opening part of an inscription: "+ Te Criste auctore pontifex...", long believed to date from the 9th-10th century. Following the excavations, but based on this dating the church remains were interpreted as pre- Romanesque, and the interpretation entailed some major historical conclusions. From a more recent and careful analysis, the inscription has been correctly dated to the 6th century. With this dating as his starting-point, the author examines the fieldwork results and suggests that the block is an early-Byzantine spolium probably from the late-antique site of Kolovrat near Prijepolje, reused in the medieval period as a tombstone in the churchyard, where such examples are not lonely. It follows that the inscribed block is not directly relatable to the church remains and that it cannot be used as dating evidence. On the other hand, the church remains show features of the Romanesque-Gothic style of architecture typical of the Pomorje, the Serbian Adriatic coast. According to close analogies found for some elements of its stone decoration, the date of the church could not precede the middle of the 13th century. The question remains open as to who had the church built and what its original function was, that is whether a monastic community center round it. Its founder may be sought for among members of the ruling Nemanjić house, but a church dignitary cannot be ruled out. Anumber of complex issues raised by this site are yet to be resolved, but the study should be relieved of earlier misconceptions. Fresh information about this ruined medieval church should be provided by revision excavations in the future.

  10. [Ichthyoplankton from the pier area in Limón, Costa Rica].

    Science.gov (United States)

    Dominici-Arosemena, A; Brugnoli-Olivera, E; Solano-Ulate, S; Molina-Ureña, H; Ramírez Coghi, A R

    2000-01-01

    Four sampling stations were set 200-500 m off Limon Port, Costa Rica, at an average depth of 20 m. From October 1996 to May 1997 horizontal subsuperficial trawls were done for 12 minutes at a speed of about 2 Km/h, with a 1,000 microns plancton net. A total of 28 samples were processed and 104 physical-chemistry parameter measurements were taken. Average salinity was 30.1 +/- 3.7 and dissolved oxygen 6.9 +/- 0.6 mg l-1 reflecting good aeration throughout the sampling period. This suggests good mixture and a highly dynamic hydrography. Temperature showed no drastic variations (28.0 +/- 1.7 degrees C), possibly because of the constant mixing with shallow water. The highest larval counts were for November and early January and include families common to reefs and estuaries (Balistidae, Lutjanidae) and to coastal areas (Centropomidae, Gerreidae, Haemulidae, Carangidae, Engraulidae, Hemiramphidae, and representative Pleuronectiformes) existing in a common area.

  11. TSALATS MARAHIL LI TATHWIR TA'LIM AL-LUGHAH AL-ARABIYYAH FI INDONESIA

    Directory of Open Access Journals (Sweden)

    Muhajir Muhajir

    2017-04-01

    Full Text Available The spread of Islam in Indonesia is closely related to the activity of Arabic language learning. As a code of linguistic expressions in learning Islam, the first aim in learning Arabic language in Indonesia is to fulfill people’s need in praying. In the second phase, Arabic language learning developed at many Islamic Boarding Schools. There was awareness that Arabic language was not only a tool in understanding a text, but also a tool for communication. It makes many people, especially those who studied abroad in the Middle East, motivated to innovate in the education development such as finding new concept and new teaching method especially in Arabic language teaching. In the third phase, Arabic language learning is nowadays used in a formal education and it is still in the process of completion of its curriculum, learning objective, learning material, teaching method, and its teaching media used in the teaching and learning process.

  12. Avifauna del Caribe sur asociada a ecosistemas alterados en Limón, Costa Rica

    OpenAIRE

    Villegas Arguedas, Juan Carlos; Villalobos Céspedes, Jorge

    2014-01-01

    La costa caribeña de Costa Rica, una de las zonas con mayor riqueza de especies de aves en el país, es la ruta migratoria más importante en América Central. Muestreamos la costa con conteos visuales (abril-octubre 2012) y observamos 1 639 individuos de 123 especies de aves en 14 sitios de muestreo de Moín a Cahuita. Las especies más comunes fueron Psarocolius montezuma (montezuma oropéndola), Ramphocelus passerinii (tangara de Passerini) y Oryzoborus funereus (semillero pico grueso). La mayor...

  13. Curva de dinámica nutricional del cultivo del limón en Chile

    OpenAIRE

    Les Aguerrea, Helena

    2014-01-01

    Este trabajo fin de carrera tiene como principal objetivo la obtención de estándares foliares para cada uno de los nutrientes esenciales del limonero (Citrus limon (L.)) durante todo su ciclo de cultivo y válidos para todas las variedades cultivadas en la actualidad en Chile. Se ha considerado relevante el estudio de la dinámica nutricional de este frutal, dado el impacto que tiene la fertilización sobre la calidad y productividad del cultivo, y sobre la contaminación de...

  14. The Role of a LIM Only Factor, LMO-4, in Breast Cancer

    National Research Council Canada - National Science Library

    Andersen, Bogi

    2002-01-01

    .... We have now shown that expression of LMO-4 is associated with undifferentiated cellular stage of breast epithelial cells, such as that found during lobuloalveolar development in pregnancy and in breast cancer...

  15. The Role of a LIM Only Factor, LMO-4 in Breast Cancer

    National Research Council Canada - National Science Library

    Anderson, Bogi

    2003-01-01

    .... We have now shown that expression of LMO-4 is associated with undifferentiated cellular stage of breast epithelial cells, such as that found during lobuloalveolar development in pregnancy and in breast cancer...

  16. Functional Analysis of LIM Domain Proteins and Co-Factors in Breast Cancer

    National Research Council Canada - National Science Library

    Wang, Ning

    2002-01-01

    .... We have now shown that expression of LMO-4 is associated with undifferentiated cellular stage of breast epithelial cells, such as that found during lobuloalveolar development in pregnancy and in breast cancer...

  17. The Role of a LIM Only Factor, LMO-4, in Breast Cancer

    National Research Council Canada - National Science Library

    Anderson, Bogi

    2004-01-01

    .... We have now shown that expression of LMO4 is associated with undifferentiated cellular stage of breast epithelial cells, such as that found during lobuloalveolar development in pregnancy and in breast cancer...

  18. Complete genome sequence of Cellulophaga lytica type strain (LIM-21T)

    Energy Technology Data Exchange (ETDEWEB)

    Pati, Amrita [U.S. Department of Energy, Joint Genome Institute; Abt, Birte [DSMZ - German Collection of Microorganisms and Cell Cultures GmbH, Braunschweig, Germany; Teshima, Hazuki [Los Alamos National Laboratory (LANL); Nolan, Matt [Joint Genome Institute, Walnut Creek, California; Lapidus, Alla L. [Joint Genome Institute, Walnut Creek, California; Lucas, Susan [Joint Genome Institute, Walnut Creek, California; Hammon, Nancy [Joint Genome Institute, Walnut Creek, California; Deshpande, Shweta [Joint Genome Institute, Walnut Creek, California; Cheng, Jan-Fang [Joint Genome Institute, Walnut Creek, California; Tapia, Roxanne [Los Alamos National Laboratory (LANL); Han, Cliff [Los Alamos National Laboratory (LANL); Goodwin, Lynne A. [Los Alamos National Laboratory (LANL); Pitluck, Sam [Joint Genome Institute, Walnut Creek, California; Liolios, Konstantinos [Joint Genome Institute, Walnut Creek, California; Pagani, Ioanna [Joint Genome Institute, Walnut Creek, California; Mavromatis, K [U.S. Department of Energy, Joint Genome Institute; Ovchinnikova, Galina [U.S. Department of Energy, Joint Genome Institute; Chen, Amy [Joint Genome Institute, Walnut Creek, California; Palaniappan, Krishna [Joint Genome Institute, Walnut Creek, California; Land, Miriam L [ORNL; Hauser, Loren John [ORNL; Jeffries, Cynthia [Oak Ridge National Laboratory (ORNL); Detter, J. Chris [Joint Genome Institute, Walnut Creek, California; Brambilla, Evelyne-Marie [DSMZ - German Collection of Microorganisms and Cell Cultures GmbH, Braunschweig, Germany; Kannan, K. Palani [DSMZ - German Collection of Microorganisms and Cell Cultures GmbH, Braunschweig, Germany; Rohde, Manfred [HZI - Helmholtz Centre for Infection Research, Braunschweig, Germany; Spring, Stefan [DSMZ - German Collection of Microorganisms and Cell Cultures GmbH, Braunschweig, Germany; Goker, Markus [DSMZ - German Collection of Microorganisms and Cell Cultures GmbH, Braunschweig, Germany; Woyke, Tanja [Joint Genome Institute, Walnut Creek, California; Bristow, James [Joint Genome Institute, Walnut Creek, California; Eisen, Jonathan [Joint Genome Institute, Walnut Creek, California; Markowitz, Victor [Joint Genome Institute, Walnut Creek, California; Hugenholtz, Philip [U.S. Department of Energy, Joint Genome Institute; Kyrpides, Nikos C [Joint Genome Institute, Walnut Creek, California; Klenk, Hans-Peter [DSMZ - German Collection of Microorganisms and Cell Cultures GmbH, Braunschweig, Germany; Ivanova, N [U.S. Department of Energy, Joint Genome Institute

    2011-01-01

    Cellulophaga lytica (Lewin 1969) Johansen et al. 1999 is the type species of the genus Cellulophaga, which belongs to the family Flavobacteriaceae within the phylum 'Bacteroidetes' and was isolated from marine beach mud in Limon, Costa Rica. The species is of biotechnological interest because its members produce a wide range of extracellular enzymes capable of degrading proteins and polysaccharides. After the genome sequence of Cellulophaga algicola this is the second completed genome sequence of a member of the genus Cellulophaga. The 3,765,936 bp long genome with its 3,303 protein-coding and 55 RNA genes consists of one circular chromosome and is a part of the Genomic Encyclopedia of Bacteria and Archaea project.

  19. Põhjamaade kunsti korraliku välimääraja leiab Kumust / Siram

    Index Scriptorium Estoniae

    Siram, pseud., 1968-

    2009-01-01

    Näitus "I Love Malmö" Kumu Kunstimuuseumis 17. jaanuarini 2010, kuraatorid Eha Komissarov ja Maria-Kristiina Soomre. Eksponeeritakse valikut Malmö kunstimuuseumi kogudest. Andy Warholilt on näitusel neli Mao Zedongi siiditrükis portreed. Joseph Beuys'i loomingust eksponeeritakse "Haisuskulptuuri". Nimetatud eksponeeritud töid ja nende autoreid

  20. Clave para la Identificación de Ocho Variedades de Limón.

    Directory of Open Access Journals (Sweden)

    Ríos C. Danilo

    1960-12-01

    Full Text Available El autor propone una guía para la descripción de frutos cítricos teniendo en cuenta los caracteres externos e internos del fruto, principalmente. Se describieron con su auxilio las variedades de Limones: Variegado, Meyer, Nativo, Mexicano, Rugoso, Génova, Perrine y Bonnie Brae; éstos dos últimos mediante consultas bibliográficas. Las descripciones permitieron la elaboración de una clave dicotómica y paralela para la identificación de las variedades que existen en la colección de la Granja Agrícola Experimental de Palmira. Las mismas descripciones mostraron la gran similitud que representan las variedades de Limones Nativo y Mexicano, sugiriendo la posibilidad de ser genéticamente idénticas./Abstract A method for describing citric fruits is proposed, based on their external and internal caractheristics. Using this method a description is given of the following varieties of lemon: Variegado, Meyer, Nativo, Mexicano, Génova, Perrine and Bonnie Brae. The last two were described from references. The description in this way permited the elaboration of dicotomic key for the identification of the varieties now planted at the Palmira’s Agricultural Experiment Station. In doing this a great similarity was found between the varieties Mexicano and Nativo suggesting the possibility of the two being genetically identical.

  1. Ictioplancton en la zona portuaria de Limón, Costa Rica

    Directory of Open Access Journals (Sweden)

    Arturo Dominici-Arosemena

    2000-06-01

    Full Text Available Four sampling stations were set 200-500m off Limon Port, Costa Rica, at an average depth of 20 m. From October 1996 to May 1997 horizontal subsuperficial trawls were done for 12 minutes at a speed of 1.853 Km/h, with a 1 000 µm net were surveyed with. A total of 28 samples were processed and 104 physical-chemistry parameter measurements were taken. Average salinity was 30.1 + 3.7 and dissolved oxygen 6.9 + 0.6 mg l-1 reflecting good aeration throughout the sampling period. This suggests good mixture and a highly dynamic hydrography. Temperature showed no drastic variations (28.0 + 1.7 °C, possibly because of the constant mixing with shallow water. The highest larval counts were for November and early January and include families from reefs and estuaries (Balistidae, Lutjanidae and from coastal areas (Centropomidae, Gerreidae, Haemulidae, Carangidae, Engraulidae, Hemirramphidae, and representative Pleuronectiformes existing in a common area.

  2. Eesti maarahva välimääraja / Andres Kaera

    Index Scriptorium Estoniae

    Kaera, Andres

    2007-01-01

    Näitus "Eesti maarahvas baltisaksa kunstis" Eesti Rahva Muuseumis. A. von Uexkülli (autorsus küsimärgi all), Friedrich Sigismund Sterni, Ernst Hermann Schlichtingi, Theodor Gehlhaari ja August Georg Wilhelm Pezoldi töödest

  3. "Let's See if It Won't Go Away by Itself." LGBT Microaggressions among Teachers in South Africa

    Science.gov (United States)

    Francis, Dennis A.; Reygan, Finn

    2016-01-01

    We explored types and qualities of microaggressions or subtle forms of discrimination towards lesbian, gay, bisexual and transgender (LGBT) people among teachers in South Africa. For data collection, we used in-depth interviews. Twenty-five Life Orientation teachers, nine men and 16 women, from both rural and urban schools throughout the Free…

  4. A field guide to real-time culture change: just "rolling out" a training program won't cut it.

    Science.gov (United States)

    Kusy, Mitchell; Holloway, Elizabeth L

    2014-01-01

    Presented as a representative case of how to handle the disruptive behaviors of professionals in healthcare, this article describes the strategies of a systems approach with a five-phase model for culture change. The "large-scale, real-time" culture change process, based on our own evidence-based research on toxic behaviors and the research of others, has been demonstrated to be more effective than one-on-one feedback to change these behaviors. The real-time approach has been applied to other organizational situations--strategy formulation, change management, or service improvement--with more sustainable effects than simply training alone. This article will help your organization with four outcomes: understanding the rationale for a five-phase model for cultural change, describing the advantages of a real-time versus nonreal-time approach to change, identifying the how-to's for application within a systems approach, and articulating a clear evaluation process to sustain successful organizational culture change.

  5. 'I won't be able to go home being pregnant': sex work and pregnancy in Dhaka, Bangladesh.

    Science.gov (United States)

    Katz, Karen R; McDowell, Misti; Johnson, Laura; Aziz, Sultana

    2016-07-01

    Sex workers report high rates of unintended pregnancy that are inconsistent with widespread reports of condom use. Greater understanding of the implications of an unintended pregnancy and barriers to contraceptive use is needed to better meet the broader sexual and reproductive health needs of this population. We conducted in-depth interviews with 20 women sex workers in Dhaka, Bangladesh. Findings reveal that most women are trying to conform to societal norms and protect their reputations. They fear pregnancy would reveal that they are having unsanctioned sex and that they are sex workers. This could lead to ostracism from families and society, resulting in homelessness and abandonment by partners. Pregnancy may affect a sex worker's ability to work and leave her unable to meet financial obligations. All study participants were using condoms but most acknowledged they could not use them consistently. They had all tried other contraceptive methods, notably injectables and the pill, but some noted experience of side-effects, difficulties in adherence and the desire to use other methods. Understanding the context of sex workers' lives is an important step in informing stakeholders about the range of services needed to improve their sexual and reproductive health.

  6. From fission to fusion: a perspective on the research that won the Nobel Prize in Physiology or Medicine, 2013.

    Science.gov (United States)

    Ray, Krishanu

    2014-03-01

    Secretion is widespread in all eukaryotic cells: all of us experience this in the course of daily life--saliva, mucus, sweat, tears, bile juice, adrenalin, etc.--the list is extremely long. How does a cell manage to repeatedly spit out some stuff without losing the rest? The answer is: through regulated vesicle trafficking within the cell. The Nobel Prize in Physiology or Medicine 2013 was awarded to Drs Randy Schekman, James E Rothman and Thomas C Südhof for their 'discoveries of machinery regulating vesicle traffic, a major transport system in our cells'. Dr Randy Schekman and his colleagues discovered a number of genes required for vesicle trafficking from the endoplasmic reticulum (ER) and Golgi; the James E Rothman group unravelled the protein machinery that allows vesicles to bud off from the membrane and fuse to their targets; and Dr Thomas C Südhof along with his colleagues revealed how calcium ions could instruct vesicles to fuse and discharge their contents with precision. These enabled the biotechnology industry to produce a variety of pharmaceutical and industrial products like insulin and hepatitis B vaccines, in a cost-efficient manner, using yeast and tissue cultured cells.

  7. Women, peace and security: The agenda is not women and it won't achieve peace or security

    National Research Council Canada - National Science Library

    Fryer, Denna

    2016-01-01

    This article argues that positive discrimination measures, as a by-product of the requirement for the ADF to fulfil its obligations to the 'Australian National Action Plan on Women, Peace and Security...

  8. Perceptual bias in pain: a switch looks closer when it will relieve pain than when it won't.

    Science.gov (United States)

    Tabor, Abby; Catley, Mark J; Gandevia, Simon; Thacker, Michael A; Lorimer Moseley, G

    2013-10-01

    Pain is fundamental to survival, as are our perceptions of the environment. It is often assumed that we see our world as a read-out of the sensory information that we receive; yet despite the same physical makeup of our surroundings, individuals perceive differently. What if we "see" our world differently when we experience pain? Until now, the causal effect of experimental pain on the perception of an external stimulus has not been investigated. Eighteen (11 female) healthy volunteers participated in this randomised repeated-measures experiment, in which participants estimated the distance to a switch placed on the table in front of them. We varied whether or not the switch would instantly stop a stimulus, set to the participant's pain threshold, being delivered to their hand, and whether or not they were required to reach for the switch. The critical result was a strong interaction between reaching and pain [F(1,181)=4.8, P=0.03], such that when participants experienced pain and were required to reach for a switch that would turn off the experimental stimulus, they judged the distance to that switch to be closer, as compared to the other 3 conditions (mean of the true distance 92.6%, 95% confidence interval 89.7%-95.6%). The judged distance was smaller than estimates in the other 3 conditions (mean±SD difference >5.7%±2.1%, t(181) >3.5, P<0.01 for all 3 comparisons). We conclude that the perception of distance to an object is modulated by the behavioural relevance of the object to ongoing pain. Copyright © 2013 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.

  9. "Most Won't Do It!" Examining Homework as a Structure for Learning in a Diverse Middle School

    Science.gov (United States)

    Bennett, Cory A.

    2017-01-01

    Much attention is placed on helping students develop as complex and creative thinkers, yet many classrooms continue to use learning structures without examining their effectiveness. This is often the case with homework. Research findings on the effectiveness of homework are mixed, and few studies have examined students' and educators' perspectives…

  10. The hard-won benefits of familiarity in visual search: naturally familiar brand logos are found faster.

    Science.gov (United States)

    Qin, Xiaoyan Angela; Koutstaal, Wilma; Engel, Stephen A

    2014-05-01

    Familiar items are found faster than unfamiliar ones in visual search tasks. This effect has important implications for cognitive theory, because it may reveal how mental representations of commonly encountered items are changed by experience to optimize performance. It remains unknown, however, whether everyday items with moderate levels of exposure would show benefits in visual search, and if so, what kind of experience would be required to produce them. Here, we tested whether familiar product logos were searched for faster than unfamiliar ones, and also familiarized subjects with previously unfamiliar logos. Subjects searched for preexperimentally familiar and unfamiliar logos, half of which were familiarized in the laboratory, amongst other, unfamiliar distractor logos. In three experiments, we used an N-back-like familiarization task, and in four others we used a task that asked detailed questions about the perceptual aspects of the logos. The number of familiarization exposures ranged from 30 to 84 per logo across experiments, with two experiments involving across-day familiarization. Preexperimentally familiar target logos were searched for faster than were unfamiliar, nonfamiliarized logos, by 8 % on average. This difference was reliable in all seven experiments. However, familiarization had little or no effect on search speeds; its average effect was to improve search times by 0.7 %, and its effect was significant in only one of the seven experiments. If priming, mere exposure, episodic memory, or relatively modest familiarity were responsible for familiarity's effects on search, then performance should have improved following familiarization. Our results suggest that the search-related advantage of familiar logos does not develop easily or rapidly.

  11. You won't know if you're improving unless you measure: recommendations for evaluating Hospice-Veteran Partnerships.

    Science.gov (United States)

    Jones, Diane; Edes, Thomas; Shreve, Scott; Casarett, David J

    2006-11-01

    Growing evidence indicates that there are abundant opportunities to improve the care that patients receive near the end of life. Hospice care has been associated with improvements in these and other outcomes, but hospice is underused by most patient populations. Therefore, the Department of Veterans Affairs (VA) has made hospice access a priority in its plan to improve end-of-life care for all veterans. In addition to committing funding for hospice care, the VA has also established a national network of Hospice-Veteran Partnerships (HVPs) whose goal is to improve access to hospice for veterans. This article describes the results of a nationwide consensus project to develop measures of the success of HVPs and recommends key measures that should be used to track improvements and to identify opportunities for highly successful collaborative strategies.

  12. Can't Count or Won't Count? Embedding Quantitative Methods in Substantive Sociology Curricula: A Quasi-Experiment.

    Science.gov (United States)

    Williams, Malcolm; Sloan, Luke; Cheung, Sin Yi; Sutton, Carole; Stevens, Sebastian; Runham, Libby

    2016-06-01

    This paper reports on a quasi-experiment in which quantitative methods (QM) are embedded within a substantive sociology module. Through measuring student attitudes before and after the intervention alongside control group comparisons, we illustrate the impact that embedding has on the student experience. Our findings are complex and even contradictory. Whilst the experimental group were less likely to be distrustful of statistics and appreciate how QM inform social research, they were also less confident about their statistical abilities, suggesting that through 'doing' quantitative sociology the experimental group are exposed to the intricacies of method and their optimism about their own abilities is challenged. We conclude that embedding QM in a single substantive module is not a 'magic bullet' and that a wider programme of content and assessment diversification across the curriculum is preferential.

  13. I Want to but I Won't: Pluralistic Ignorance Inhibits Intentions to Take Paternity Leave in Japan.

    Science.gov (United States)

    Miyajima, Takeru; Yamaguchi, Hiroyuki

    2017-01-01

    The number of male employees who take paternity leave in Japan has been low in past decades. However, the majority of male employees actually wish to take paternity leave if they were to have a child. Previous studies have demonstrated that the organizational climate in workplaces is the major determinant of male employees' use of family-friendly policies, because males are often stigmatized and fear receiving negative evaluation from others. While such normative pressure might be derived from prevailing social practices relevant to people's expectation of social roles (e.g., "Men make houses, women make homes"), these social practices are often perpetuated even after the majority of group members have ceased to support them. The perpetuation of this unpopular norm could be caused by the social psychological phenomenon of pluralistic ignorance. While researches have explored people's beliefs about gender roles from various perspectives, profound understanding of these beliefs regarding gender role norms, and the accuracy of others' beliefs remains to be attained. The current research examined the association between pluralistic ignorance and the perpetually low rates of taking paternity leave in Japan. Specifically, Study 1 (n = 299) examined Japanese male employees' (ages ranging from the 20 s to the 40 s) attitudes toward paternity leave and to estimate attitudes of other men of the same age, as well as behavioral intentions (i.e., desire and willingness) to take paternity leave if they had a child in the future. The results demonstrated that male employees overestimated other men's negative attitudes toward paternity leave. Moreover, those who had positive attitudes toward taking leave and attributed negative attitudes to others were less willing to take paternity leave than were those who had positive attitudes and believed others shared those attitudes, although there was no significant difference between their desires to take paternity leave. Study 2 (n = 425) replicated these results and further indicated that they could not be explained by the participants' needs to be socially desirable. Together, our findings suggest that pluralistic ignorance occurs in the context of taking paternity leave in Japanese men, and this leads to the low use of available paternity leave.

  14. I Want to but I Won't: Pluralistic Ignorance Inhibits Intentions to Take Paternity Leave in Japan

    Directory of Open Access Journals (Sweden)

    Takeru Miyajima

    2017-09-01

    Full Text Available The number of male employees who take paternity leave in Japan has been low in past decades. However, the majority of male employees actually wish to take paternity leave if they were to have a child. Previous studies have demonstrated that the organizational climate in workplaces is the major determinant of male employees' use of family-friendly policies, because males are often stigmatized and fear receiving negative evaluation from others. While such normative pressure might be derived from prevailing social practices relevant to people's expectation of social roles (e.g., “Men make houses, women make homes”, these social practices are often perpetuated even after the majority of group members have ceased to support them. The perpetuation of this unpopular norm could be caused by the social psychological phenomenon of pluralistic ignorance. While researches have explored people's beliefs about gender roles from various perspectives, profound understanding of these beliefs regarding gender role norms, and the accuracy of others' beliefs remains to be attained. The current research examined the association between pluralistic ignorance and the perpetually low rates of taking paternity leave in Japan. Specifically, Study 1 (n = 299 examined Japanese male employees' (ages ranging from the 20 s to the 40 s attitudes toward paternity leave and to estimate attitudes of other men of the same age, as well as behavioral intentions (i.e., desire and willingness to take paternity leave if they had a child in the future. The results demonstrated that male employees overestimated other men's negative attitudes toward paternity leave. Moreover, those who had positive attitudes toward taking leave and attributed negative attitudes to others were less willing to take paternity leave than were those who had positive attitudes and believed others shared those attitudes, although there was no significant difference between their desires to take paternity leave. Study 2 (n = 425 replicated these results and further indicated that they could not be explained by the participants' needs to be socially desirable. Together, our findings suggest that pluralistic ignorance occurs in the context of taking paternity leave in Japanese men, and this leads to the low use of available paternity leave.

  15. I Can, But I Won’t: An Exploratory Study on People and New Information Technologies in the Military

    Science.gov (United States)

    2011-03-01

    environment for running public services ( Glick , 2009). European nations are also implementing IT solutions around cloud computing services in... Thomas , and Reinsch (2004) followed communication scholars in predicting that the perceived attributes of a new technology will significantly affect...situations that would affect the relative importance of the perceived attributes of the technology (Turner, Thomas , and Reinsch, 2004). Successful

  16. Sound Bites Won't Prepare the Next Generation: Early Childhood Teacher Education Policy Public-Private Divide in Massachusetts

    Science.gov (United States)

    Abbate-Vaughn, Jorgelina; Paugh, Patricia C.; Douglass, Anne

    2011-01-01

    The political emphasis on early education speaks of growing expectations for equal access and the need to ensure quality--by way of standard accountability measures--on behalf of all young children. A central element in the improvement of early education focuses on teacher quality. In this article we examine and discuss the challenges related to…

  17. "Why won't they just vaccinate?" Horse owner risk perception and uptake of the Hendra virus vaccine.

    Science.gov (United States)

    Manyweathers, J; Field, H; Longnecker, N; Agho, K; Smith, C; Taylor, M

    2017-04-13

    Hendra virus is a paramyxovirus that causes periodic serious disease and fatalities in horses and humans in Australia first identified in 1994. Pteropid bats (commonly known as flying-foxes) are the natural host of the virus, and the putative route of infection in horses is by ingestion or inhalation of material contaminated by flying-fox urine or other bodily fluids. Humans become infected after close contact with infected horses. Horse owners in Australia are encouraged to vaccinate their horses against Hendra virus to reduce the risk of Hendra virus infection, and to prevent potential transmission to humans. After the vaccine was released in 2012, uptake by horse owners was slow, with some estimated 11-17% of horses in Australia vaccinated. This study was commissioned to examine barriers to vaccine uptake and potential drivers to future adoption of vaccination by horse owners. This study examined qualitative comments from respondents to an on-line survey, reporting reasons for not vaccinating their horses. The study also investigated scenarios in which respondents felt they might consider vaccinating their horses. Self-reported barriers to uptake of the Hendra virus vaccine by horse owners (N = 150) included concerns about vaccine safety, cost, and effectiveness. Reduction in vaccination costs and perception of immediacy of Hendra virus risk were reported as being likely to change future behaviour. However, the data also indicated that horse owners generally would not reconsider vaccinating their horses if advised by their veterinarian. While changes to vaccine costs and the availability data supporting vaccine safety and efficacy may encourage more horse owners to vaccinate, this study highlights the importance of protecting the relationship between veterinarians and horse owners within the risk management strategies around Hendra virus. Interactions and trust between veterinarians and animal owners has important implications for management of and communication around Hendra virus and other zoonotic disease outbreaks.

  18. What You Don't Know Won't Hurt Me: Impression Management Functions of Communication Channels in Relationships.

    Science.gov (United States)

    O'Sullivan, Patrick B.

    2000-01-01

    Addresses the implications of interpersonal communication technology use for personal relationships. Tests elements of an impression management model, which specifies the processes and outcomes of strategic uses of channel and message for self-presentational goals. Supports a functional perspective that views mediated communication channels as a…

  19. Line Manager Involvement in Work-Life Balance and Career Development: Can't Manage, Won't Manage?

    Science.gov (United States)

    Dick, Penny; Hyde, Rosie

    2006-01-01

    Line manager involvement in HRM is an increasing trend across Europe. With the numbers of employees taking advantage of work-life balance policies also on the increase, line manager responsibility for this specific policy area is likely to become more marked. In this paper, we argue that line managers have a critical role to play in the career…

  20. Why National Standards Won't Fix American Education: Misalignment of Power and Incentives. Backgrounder. No. 2413

    Science.gov (United States)

    Burke, Lindsey M.; Marshall, Jennifer A.

    2010-01-01

    American education needs to be fixed, but national standards and testing are not the way to do it. The problems that need fixing are too deeply ingrained in the power and incentive structure of the public education system, and the renewed focus on national standards threatens to distract from the fundamental issues. Besides, federal control over…

  1. Going "Back to Basics" in Mathematics Won't Prove Who's "Right," but Who's "Left" (Brain Duality and Mathematics Learning).

    Science.gov (United States)

    Elliott, Portia C.

    1980-01-01

    The aims of the article are: (1) to outline the general tenets of the "back to basics" movements; (2) to indicate how these tenets go counter to emerging research on hemispheric specialization; and (3) to suggest methods which are brain-compatible and likely to produce competent creative problem solvers. (Author/TG)

  2. "Drinking won't get you thinking": a content analysis of adolescent-created print alcohol counter-advertisements.

    Science.gov (United States)

    Banerjee, Smita C; Greene, Kathryn; Hecht, Michael L; Magsamen-Conrad, Kate; Elek, Elvira

    2013-01-01

    Involvement in creating antialcohol advertisements generates enthusiasm among adolescents; however, little is known about the messages adolescents develop for these activities. In this article, we present a content analysis of 72 print alcohol counteradvertisements created by high school (age 14-17 years old) and college (18-25 years old) students. The posters were content analyzed for poster message content, persuasion strategies, and production components, and we compared high school and college student posters. All of the posters used a slogan to highlight the main point/message of the ad and counterarguments/consequences to support the slogans. The most frequently depicted consequences were negative consequences of alcohol use, followed by negative-positive consequence comparison. Persuasion strategies were sparingly used in advertisements and included having fun/one of the gang, humor/unexpected, glamour/sex appeal, and endorsement. Finally, posters displayed a number of production techniques including depicting people, clear setting, multiple colors, different font sizes, and object placement. College and high school student-constructed posters were similar on many features (e.g., posters displayed similar frequency of utilization of slogans, negative consequences, and positive-negative consequence comparisons), but were different on the use of positive consequences of not using alcohol and before-after comparisons. Implications for teaching media literacy and involving adolescents and youth in developing alcohol prevention messages are discussed.

  3. There's More to Groove than Bass in Electronic Dance Music: Why Some People Won't Dance to Techno.

    Directory of Open Access Journals (Sweden)

    Brian C Wesolowski

    Full Text Available The purpose of this study was to explore the relationship between audio descriptors for groove-based electronic dance music (EDM and raters' perceived cognitive, affective, and psychomotor responses. From 198 musical excerpts (length: 15 sec. representing 11 subgenres of EDM, 19 low-level audio feature descriptors were extracted. A principal component analysis of the feature vectors indicated that the musical excerpts could effectively be classified using five complex measures, describing the rhythmical properties of: (a the high-frequency band, (b the mid-frequency band, and (c the low-frequency band, as well as overall fluctuations in (d dynamics, and (e timbres. Using these five complex audio measures, four meaningful clusters of the EDM excerpts emerged with distinct musical attributes comprising music with: (a isochronous bass and static timbres, (b isochronous bass with fluctuating dynamics and rhythmical variations in the mid-frequency range, (c non-isochronous bass and fluctuating timbres, and (d non-isochronous bass with rhythmical variations in the high frequencies. Raters (N = 99 were each asked to respond to four musical excerpts using a four point Likert-Type scale consisting of items representing cognitive (n = 9, affective (n = 9, and psychomotor (n = 3 domains. Musical excerpts falling under the cluster of "non-isochronous bass with rhythmical variations in the high frequencies" demonstrated the overall highest composite scores as evaluated by the raters. Musical samples falling under the cluster of "isochronous bass with static timbres" demonstrated the overall lowest composite scores as evaluated by the raters. Moreover, music preference was shown to significantly affect the systematic patterning of raters' responses for those with a musical preference for "contemporary" music, "sophisticated" music, and "intense" music.

  4. There's More to Groove than Bass in Electronic Dance Music: Why Some People Won't Dance to Techno.

    Science.gov (United States)

    Wesolowski, Brian C; Hofmann, Alex

    2016-01-01

    The purpose of this study was to explore the relationship between audio descriptors for groove-based electronic dance music (EDM) and raters' perceived cognitive, affective, and psychomotor responses. From 198 musical excerpts (length: 15 sec.) representing 11 subgenres of EDM, 19 low-level audio feature descriptors were extracted. A principal component analysis of the feature vectors indicated that the musical excerpts could effectively be classified using five complex measures, describing the rhythmical properties of: (a) the high-frequency band, (b) the mid-frequency band, and (c) the low-frequency band, as well as overall fluctuations in (d) dynamics, and (e) timbres. Using these five complex audio measures, four meaningful clusters of the EDM excerpts emerged with distinct musical attributes comprising music with: (a) isochronous bass and static timbres, (b) isochronous bass with fluctuating dynamics and rhythmical variations in the mid-frequency range, (c) non-isochronous bass and fluctuating timbres, and (d) non-isochronous bass with rhythmical variations in the high frequencies. Raters (N = 99) were each asked to respond to four musical excerpts using a four point Likert-Type scale consisting of items representing cognitive (n = 9), affective (n = 9), and psychomotor (n = 3) domains. Musical excerpts falling under the cluster of "non-isochronous bass with rhythmical variations in the high frequencies" demonstrated the overall highest composite scores as evaluated by the raters. Musical samples falling under the cluster of "isochronous bass with static timbres" demonstrated the overall lowest composite scores as evaluated by the raters. Moreover, music preference was shown to significantly affect the systematic patterning of raters' responses for those with a musical preference for "contemporary" music, "sophisticated" music, and "intense" music.

  5. The European Universities, Citizenship and Its Limits: What Won't Solve the Problems of Our Time

    Science.gov (United States)

    Lock, Grahame; Martins, Herminio

    2009-01-01

    This article attempts to weave together in an original manner a number of themes regarding citizenship and higher education in Europe. Thus, the authors look critically at the notion of citizenship itself; its role in Aristotle and in Hegel's state-versus-civil-society contrast; its relation to the world of work or labour; its connection with the…

  6. Hate Won, but Love Will Have the Final Word: Critical Pedagogy, Liberation Theology, and the Moral Imperative of Resistance

    Science.gov (United States)

    Kirylo, James D

    2017-01-01

    In the context of the recent presidential election in the United States, this article examines the place of critical pedagogy and liberation theology and its positionality in impacting the moral imperative of resisting a climate of hate and intolerance. Particularly drawing from the work of Peter McLaren, Gustavo Gutiérrez, Paulo Freire and…

  7. How to get patients seen when they need it (or how we fought the matrix and won).

    Science.gov (United States)

    Mattingly, Heidi

    2012-01-01

    Before the recession, growth was easy. The environment was fairly predictable, and returns on investment came quickly. With little difficulty, a private practice could increase the total services it provided, resulting in increased patient encounters and increased profit. But the growth of Maryland's largest and oldest orthopaedic practice came with a price: a jumbled, imposing document known as "the matrix" that governed a troubled appointment process. OrthoMaryland knew the matrix had to go but lacked an incentive to do the work needed to replace it. Then came the recession, which made borrowing money for a private specialty practice like OrthoMaryland as difficult as borrowing money for a home loan. At the same time, the Patient Protection and Affordable Care Act is transforming the way private practices will be reimbursed for services. The changes to the fee-for-service model plus the increased emphasis on patient satisfaction meant the practice would need to both increase the number of patients seen and make them more satisfied at the same time. And that meant the matrix had to go.

  8. They Won't Accept the What of Science If They Don't Get the Why and How

    Science.gov (United States)

    Holt, Rush

    2016-03-01

    Denial of evidence by policy makers on controversial issues, substituting ideology for research-based findings, and suspicion of scientists of bias or even conspiracy are all enormously distasteful and sometimes bewildering to scientists. Whatever the subject-climate change, nuclear power, or GMO's- scientists should understand that the problems originate, not with demagogic or misguided politicians, but rather with millions of Americans who do not appreciate the essence of science and have a poor understanding of the basic nature and procedures of science. The public appreciation of science shows signs of further erosion, suggesting that the problems may get even worse in the future. Scientists do little to help the problem by insistently trying to teach the specifics of the controversial subjects, however clearly and logically, when the public does not even understand how science works.

  9. Simulation Suggests that medical group mergers won't undermine the potential utility of health information exchanges.

    Science.gov (United States)

    Rudin, Robert S; Schneider, Eric C; Volk, Lynn A; Szolovits, Peter; Salzberg, Claudia A; Simon, Steven R; Bates, David W

    2012-03-01

    Federal and state agencies are investing substantial resources in the creation of community health information exchanges, which are consortia that enable independent health care organizations to exchange clinical data. However, under pressure to form accountable care organizations, medical groups may merge and support private health information exchanges. Such activity could reduce the potential utility of community exchanges-that is, the exchanges' capacity to share patient data across hospitals and physician practices that are independent. Simulations of care transitions based on data from ten Massachusetts communities suggest that there would have to be many such mergers to undermine the potential utility of health information exchanges. At the same time, because hospitals and the largest medical groups account for only 10-20 percent of care transitions in a community, information exchanges will still need to recruit a large proportion of the medical groups in a given community for the exchanges to maintain their usefulness in fostering information exchange across independent providers.

  10. Optical and Electromagnetic Properties of LaCoO3:Li+;M2+ (M = Ca, Sr, Ba)

    Science.gov (United States)

    Fesich, I. V.; Trachevsky, V. V.; Dziazko, A. G.; Nedilko, S. A.; Melnik, A. K.

    2014-09-01

    Lanthanum cobaltates modified by alkaline-earth-metal (0.10 mol%) and lithium (0.05 mol%) ions were synthesized. The samples had an orthorhombic distorted perovskite-like structure according to x-ray diffraction phase analysis. Addition of Li+ and M2+ (M = Ca, Sr, Ba) to the LaCoO3 matrix was shown to increase the unit-cell parameters, the optical band width (Eg), and the average Co oxidation state (Con+). Pure and doped LaCoO3 were characterized by the presence of paramagnetic centers as isolated structural and surface Co2+ ions and adsorption complexes [Co3 + ⋯ O{2/-}]· on the surface of the oxide matrix at a concentration that increased in the order Ba > Sr > Ca. The cobaltates were found to possess Mott hopping conduction in the temperature range 77-298 K.

  11. In-Sik Shin, Mee-Young Lee, Hye-Sun Lim, Chang-Seob Seo, Hye ...

    African Journals Online (AJOL)

    AJTCAM

    Rats in the positive control group were given omeprazole orally (50 mg/kg ... indicate that LJT protects gastric mucosa against ethanol-induced acute ..... constituent, thymoquinone against acute alcohol-induced gastric mucosal injury in rats.

  12. Miniature LIMS system designed for sensitive in situ measurements of organic deposits in materials on solar system objects

    Science.gov (United States)

    Riedo, Andreas; Moreno-García, Pavel; Grimaudo, Valentine; Brigitte Neuland, Maike; Tulej, Marek; Broekmann, Peter; Wurz, Peter

    2014-05-01

    In situ investigation of chemical composition is of considerable interest for application in planetary missions. The possibility of bio-relevant organic chemistry on the surfaces of comets and primitive asteroids is one of the most intriguing problems of the current astrobiology. Rock-water interface existed in early small solar body history, in addition to extensive mineralogical modifications of the surface could have initiated also a rich organic and bio-organic chemistry [1]. Current space instrumentation designed for molecular detection use thermal evaporation source combined with gas chromatography (GC) and mass spectrometry [2]. Hence, it is capable of collecting data of the volatile fraction of the investigated sample. Laser desorption mass spectrometry (LD-MS) is another method for molecule detection capable of vaporisation and ionisation of molecules present on a solid substrate surface, e.g. a rock. A miniature laser ablation ionisation reflectron-type time-of-flight mass analyser (LMS) developed by our group for in situ measurements of the elemental, isotopic composition can be used also for sensitive analyses of chemical compounds present on solid surfaces with high spatial resolution [3-6]. Comparing to laser ablation laser desorption analyses are conducted at laser irradiance reduced by approximately 103-104 times. In laser ablation mode, the LMS system offers high dynamic range of at least eight orders of magnitude and allows for the detection in the ppb range for metallic- and non-metallic elements. Instrument mass resolution m/Δm is about 800 at the 56Fe mass peak when the instrument is used in ablation mode. The mass resolution is increased to m/Δm >1000 when desorption studies are conducted (at ~600 m/q). We will demonstrate the instrument performance conducting molecular desorption studies of different species, e.g. organic, biotic and abiotic. Laser ablation/ionisation studies are conducted in parallel to complement the laser desorption analyses. References 1)S. Pizzarello, Y. Huang, M.R. Alexandre, 'Molecular asymmetry in extraterrestrial chemistry: insights from a pristine meteorite', PNAS, 2008, 105, pp. 3700 - 3704. 2)L. A. Leshin et al., Volatile, isotope, and organic analysis of Martian fines with the Mars Curiosity rover, Science, 2013, 341, 1238937, pp. 1 - 9. 3)A. Riedo, M. Neuland, S. Meyer, M. Tulej, and P. Wurz, 'Coupling of LMS with a fs-laser ablation ion source: elemental and isotope composition measurements', J. Anal. At. Spectrom., 2013, 28, pp. 1256 - 1269. 4)A. Riedo, S. Meyer, B. Heredia, M.B. Neuland, A. Bieler, M. Tulej, I. Leya, M. Iakovleva, K. Mezger, and P. Wurz, 'Highly accurate isotope composition measurements by a miniature laser ablation mass spectrometer designed for in situ investigations on planetary surfaces', Planet. Space Sci., 2013, 87, pp. 1 - 13. 5)A. Riedo, P. Wahlström, J.A. Scheer, P. Wurz, and M. Tulej, 'Effect of long duration UV irradiation on diamondlike carbon surfaces in the presence of a hydrocarbon gaseous atmosphere', J. Appl. Phys., 2010, 108, 114915, pp.1 - 8. 6)M. Tulej, M. Iakovleva, I. Leya, and P. Wurz, 'A miniature mass analyser for in-situ elemental analysis of planetary material - performance studies', Anal. Bioanal. Chem., 2011, 399, pp. 2185 - 2200.

  13. The C terminus of the synovial sarcoma-associated SSX proteins interacts with the LIM homeobox protein LHX4.

    NARCIS (Netherlands)

    Bruijn, D.R.H. de; Dijk, A.H.A.; Willemse, M.P.; Geurts van Kessel, A.H.M.

    2008-01-01

    As a result of the synovial sarcoma-associated t(X;18) translocation, the SS18 gene on chromosome 18 is fused to either one of the three closely related SSX genes on the X chromosome. The SS18 protein is thought to act as a transcriptional co-activator, whereas the SSX proteins are thought to act as

  14. Argonaute Utilization for miRNA Silencing Is Determined by Phosphorylation-Dependent Recruitment of LIM-Domain-Containing Proteins

    Directory of Open Access Journals (Sweden)

    Katherine S. Bridge

    2017-07-01

    Full Text Available As core components of the microRNA-induced silencing complex (miRISC, Argonaute (AGO proteins interact with TNRC6 proteins, recruiting other effectors of translational repression/mRNA destabilization. Here, we show that LIMD1 coordinates the assembly of an AGO-TNRC6 containing miRISC complex by binding both proteins simultaneously at distinct interfaces. Phosphorylation of AGO2 at Ser 387 by Akt3 induces LIMD1 binding, which in turn enables AGO2 to interact with TNRC6A and downstream effector DDX6. Conservation of this serine in AGO1 and 4 indicates this mechanism may be a fundamental requirement for AGO function and miRISC assembly. Upon CRISPR-Cas9-mediated knockout of LIMD1, AGO2 miRNA-silencing function is lost and miRNA silencing becomes dependent on a complex formed by AGO3 and the LIMD1 family member WTIP. The switch to AGO3 utilization occurs due to the presence of a glutamic acid residue (E390 on the interaction interface, which allows AGO3 to bind to LIMD1, AJUBA, and WTIP irrespective of Akt signaling.

  15. 1 r urT log ),( r t lim ),( ) ( , urT urrT r r

    African Journals Online (AJOL)

    Preferred Customer

    E. iϕ)dϕ, (0 ≤ θ ≤ π, r > 0) where the supermum is taken over all sets E ⊆ [-π, π] with m(E) = 2θ (m = Lebesgue measure on the real line). Baernstein (1974) proved that u* is subharmonic in the upper half plane, π+ and continuous in the closure of π+ except possibly at the origin. Further, u* also satisfy (see also Hyman,.

  16. PDZ motifs in PTP-BL and RIL bind to internal protein segments in the LIM domain protein RIL

    NARCIS (Netherlands)

    Cuppen, E.; Gerrits, H.; Pepers, B.; Wieringa, B.; Hendriks, W.

    1998-01-01

    The specificity of protein-protein interactions in cellular signaling cascades is dependent on the sequence and intramolecular location of distinct amino acid motifs. We used the two-hybrid interaction trap to identify proteins that can associate with the PDZ motif-rich segment in the protein

  17. El arlequín de limón: una joya en extinción

    Directory of Open Access Journals (Sweden)

    Paula Peña

    2013-09-01

    Full Text Available Estos malignos y pestilentes animales…son detestables por su cuerpo frío, su palidez, esqueleto cartilaginoso, piel desagradable, aspecto feroz, ojos calculadores, olor irritante, voz chillona, moradas miserables y terrible veneno”. Así describió el naturalista sueco Carl Von Linneo en 1758 a los anfibios (Linneo, citado por Wells, 2007: 1. En la actualidad la reputación de sapos y ranas ha mejorado considerablemente, pero todavía existen aquellos que tienen una idea equivocada de estos animales. Lo que estas personas no saben es que las ranas y sapos son elementos de extrema importancia en los ecosistemas naturales, la medicina y la industria turística.

  18. PARPs database: A LIMS systems for protein-protein interaction data mining or laboratory information management system

    Directory of Open Access Journals (Sweden)

    Picard-Cloutier Aude

    2007-12-01

    Full Text Available Abstract Background In the "post-genome" era, mass spectrometry (MS has become an important method for the analysis of proteins and the rapid advancement of this technique, in combination with other proteomics methods, results in an increasing amount of proteome data. This data must be archived and analysed using specialized bioinformatics tools. Description We herein describe "PARPs database," a data analysis and management pipeline for liquid chromatography tandem mass spectrometry (LC-MS/MS proteomics. PARPs database is a web-based tool whose features include experiment annotation, protein database searching, protein sequence management, as well as data-mining of the peptides and proteins identified. Conclusion Using this pipeline, we have successfully identified several interactions of biological significance between PARP-1 and other proteins, namely RFC-1, 2, 3, 4 and 5.

  19. Daño del ADN en trabajadoras bananeras expuestas a plaguicidas en Limón, Costa Rica

    Directory of Open Access Journals (Sweden)

    Vanessa Ramírez

    2002-06-01

    Full Text Available El uso de plaguicidas en los países en desarrollo es extenso en cantidad y en tiempo. Un gran porcentaje de lo que se aplica queda en el entorno y en los organismos que ahí habitan, lo que acarrea problemas de contaminación ambiental y deterioro de la salud de las personas que están en contacto con ellos. Los efectos se pueden manifestar a corto o a largo plazo y los síntomas varían desde un dolor de cabeza hasta el desarrollo de cáncer. La mayoría de los estudios en esta área se han orientado hacia los efectos agudos o crónicos y recientemente se inicia el estudio del efecto genotóxico de los plaguicidas. En e1 presente trabajo se evaluó el efecto genotóxico de los plaguicidas utilizados en las empacadoras de banano, usando como marcador biológico la electroforesis de células únicas (conocido como ensayo cometa en linfocitos aislados de sangre periférica. La población en estudio correspondió a 30 trabajadoras expuestas a plaguicidas, procedentes de 15 fincas bananeras y 28 mujeres sin antecedentes de exposición ocupacional a plaguicidas, de la misma área geográfica. Las trabajadoras que tenían entre cinco y quince años de trabajo presentaron mayor daño en la hebra sencilla del ADN (R² =0.12. Se desconoce si este efecto se debe a los plaguicidas que se utilizan actualmente o a plaguicidas empleados en el pasado. Tampoco fue posible correlacionar las dosis y las frecuencias de exposición a los plaguicidas con el daño al ADN, debido a que no existe un registro histórico sobre los productos empleados en el cultivo de banano, no se sabe por cuánto tiempo y las épocas en que fueron utilizados. Se recomienda el ensayo cometa para monitoreo genético en poblaciones expuestas a plaguicidasPesticide use in Costa Rica is very high and all year round. A high percentage of what is sprayed remains in the environment and in the living organisms around. This situation brings contamination and health problems to people in contact with them. The onset of adverse effects may be in the short or the long term, and symptoms vary widely, from headaches to cancer. Much research in this area has been devoted to acute or chronic effects, and not until recently to the genotoxic effect of pesticides. This study evaluated the genotoxic effect of pesticides used in banana packing activities, using the comet assay (single cell electrophoresis as the biological marker in lymphocytes. This was a case-control double blind study of 30 exposed women from 15 banana farms and 28 women not occupationally exposed to pesticides from the same geographic area. Results show damage to single stranded DNA after working from 5 to 15 years (R 2 =0.12. In Costa Rica we do not have an historical record of the kind of pesticides used in banana farms, the period of time and for how long were they used. This prevented further analysis concerning dose, frequency of exposure and use of new or old kind of pesticides in the farms in relation to DNA damage. The comet assay is of value in the genetic monitoring of pesticide exposed populations

  20. The Province and Port of Limón: Metaphors for Afro-Costa Rican Black Identity

    OpenAIRE

    Carmen Hutchinson Miller Ph.D

    2013-01-01

     A significant number of Afro-Caribbean immigrant workers from the Anglo Spanish, and French Caribbean migrated to the Central American country called Costa Rica, to work on the construction of a railroad, 140 years ago (1872). Strained economic conditions in their homelands in the late 19th century was the push factor that forced them out of their homes in search for better opportunities that would improve their own and the lives of the families they left behind. Large numbers of these immig...

  1. ?I won?t out myself just to do a survey?: Sexual and gender minority adolescents? perspectives on the risks and benefits of sex research

    OpenAIRE

    Macapagal, Kathryn; Coventry, Ryan; Arbeit, Miriam R.; Fisher, Celia B.; Mustanski, Brian

    2016-01-01

    Sexual and gender minority (SGM) adolescents under age 18 are underrepresented in sexual health research. Exclusion of SGM minors from these studies has resulted in a lack of knowledge about the risks and benefits youth experience from sexual health research participation. Institutional Review Boards? (IRB) overprotective stances toward research risks and requirements for guardian consent for SGM research are significant barriers to participation, though few have investigated SGM youth?s pers...

  2. Calvin Won't Sit Down! The Daily Behavior Report Card: A Practical Technique to Change Student Behavior and Increase School-Home Communication

    Science.gov (United States)

    Mires, Carolyn B.; Lee, David L.

    2017-01-01

    Calvin is a student who will not stay in his seat. He calls out constantly. Calvin does not complete his class work, and his homework is rarely returned. Do you have a student like Calvin? Does he fail to turn in homework, or act disrespectfully toward teachers and peers? Easy to implement, the Daily Behavior Report Card is an empirically based…

  3. 'The child that tiire doesn't give you, God won't give you either.' The role of Rotheca myricoides in Somali fertility practices.

    Science.gov (United States)

    Mire, Sada

    2016-12-01

    The paper introduces the Baanashada Dumarka, a Somali fertility therapy carried out by a spirit medium, known locally as 'Alaqad. Baanashada is aimed at women whose fertility issues are believed to be caused by spirits. The study also explores a component of the Baanashada, namely, the use of tiire (Rotheca myricoides), or the butterfly bush. Although Rotheca myricoides is known to possess a number of medicinal components as confirmed by studies of modern science, so far, there exist no studies on its potential (or lack of) fertility effects. Hence, the alleged fertility benefits of the butterfly bush need examining. In 2008 a British Somali woman died of herbs placed in her cervix by a traditional healer in Somaliland. This piece of information indicated not only the role of herbal medicine in fertility practices, but also the popularity of traditional reproductive medicine beyond border, class or educational background. Yet, current research into Somali women's health focuses mainly on Female Genital Mutilation (FGM), examined often without the context of wider cultural practices. This paper, however, suggests that rituals, beliefs and material culture play a paramount role in women's practices. For example, as explored elsewhere, the wagar, a wooden and sacred object made of the African olive, is critical for fertility practices. The current paper illuminates further the significance of reproduction practices in Somali society and the potential continuity of traditions associated with the perpetuation of kinship. It concludes that fertility rituals are part of a wider context of interaction with sacred landscapes, objects and archaeological sites, often associated with past legends in the Horn of Africa.

  4. Can't play, won't play: longitudinal changes in perceived barriers to participation in sports clubs across the child–adolescent transition

    Science.gov (United States)

    Basterfield, Laura; Gardner, Lauren; Reilly, Jessica K; Pearce, Mark S; Parkinson, Kathryn N; Adamson, Ashley J; Reilly, John J; Vella, Stewart A

    2016-01-01

    Background Participation in sports is associated with numerous physical and psychosocial health benefits, however, participation declines with age, and knowledge of perceived barriers to participation in children is lacking. This longitudinal study of children and adolescents aimed to use the ecological model of physical activity to assess changes in barriers to participation in sports clubs to identify age-specific and weight-specific targets for intervention. Methods Longitudinal study—Perceived barriers to sports participation were collected from a birth cohort, the Gateshead Millennium Study (n>500) at ages 9 and 12 years. The open-ended question ‘Do you find it hard to take part in sports clubs for any reason?’ was completed with free text and analysed using content analysis, and the social–ecological model of physical activity. Results Barriers from across the social-ecological model were reported. Barriers at 9 years were predominantly of a physical environmental nature, and required high parental involvement (for transport, money, permission), or were associated with a lack of suitable clubs. At 12 years, perceived barriers were predominantly classed as intrapersonal (‘they're boring’) or social environmental (‘my friends don't go’). Perceived barriers were not associated with weight status. Conclusions Perceived barriers to sports participation change rapidly in childhood and adolescence. Future interventions aiming to increase sports participation in children and adolescents should target specific age groups, should consider the rapid changes which occur in adolescence, and aim to address prominent barriers from across the socioecological model. Perceived barriers may be unrelated to current weight status, allowing for more inclusive solutions. PMID:27900159

  5. Can't play, won't play: longitudinal changes in perceived barriers to participation in sports clubs across the child?adolescent transition

    OpenAIRE

    Basterfield, Laura; Gardner, Lauren; Reilly, Jessica K; Mark S Pearce; Parkinson, Kathryn N.; Adamson, Ashley J.; Reilly, John J; Vella, Stewart A

    2016-01-01

    Background Participation in sports is associated with numerous physical and psychosocial health benefits, however, participation declines with age, and knowledge of perceived barriers to participation in children is lacking. This longitudinal study of children and adolescents aimed to use the ecological model of physical activity to assess changes in barriers to participation in sports clubs to identify age-specific and weight-specific targets for intervention. Methods Longitudinal study?Perc...

  6. Can't play, won't play: longitudinal changes in perceived barriers to participation in sports clubs across the child-adolescent transition.

    Science.gov (United States)

    Basterfield, Laura; Gardner, Lauren; Reilly, Jessica K; Pearce, Mark S; Parkinson, Kathryn N; Adamson, Ashley J; Reilly, John J; Vella, Stewart A

    2016-01-01

    Participation in sports is associated with numerous physical and psychosocial health benefits, however, participation declines with age, and knowledge of perceived barriers to participation in children is lacking. This longitudinal study of children and adolescents aimed to use the ecological model of physical activity to assess changes in barriers to participation in sports clubs to identify age-specific and weight-specific targets for intervention. Longitudinal study-Perceived barriers to sports participation were collected from a birth cohort, the Gateshead Millennium Study (n>500) at ages 9 and 12 years. The open-ended question 'Do you find it hard to take part in sports clubs for any reason?' was completed with free text and analysed using content analysis, and the social-ecological model of physical activity. Barriers from across the social-ecological model were reported. Barriers at 9 years were predominantly of a physical environmental nature, and required high parental involvement (for transport, money, permission), or were associated with a lack of suitable clubs. At 12 years, perceived barriers were predominantly classed as intrapersonal ('they're boring') or social environmental ('my friends don't go'). Perceived barriers were not associated with weight status. Perceived barriers to sports participation change rapidly in childhood and adolescence. Future interventions aiming to increase sports participation in children and adolescents should target specific age groups, should consider the rapid changes which occur in adolescence, and aim to address prominent barriers from across the socioecological model. Perceived barriers may be unrelated to current weight status, allowing for more inclusive solutions.

  7. The Next Big Thing We Won't Be Able to Live Without? Fulbright's Half-Life Theory Gives Us Some Ideas

    Science.gov (United States)

    Fulbright, Ron

    2015-01-01

    My great-grandparents lived one-half of their lives without electricity. My grandparents lived one-half of their lives without a telephone. My parents lived one-half of their lives without a television. My sister has lived one-half of her life without a computer and I have lived one-half of my life without Google. Today, we could not imagine life…

  8. Commentary on community-led total sanitation and human rights: should the right to community-wide health be won at the cost of individual rights?

    Science.gov (United States)

    Bartram, Jamie; Charles, Katrina; Evans, Barbara; O'Hanlon, Lucinda; Pedley, Steve

    2012-12-01

    The Millennium Development Goals (MDGs) set out to halve the proportion of the population without access to basic sanitation between 1990 and 2015. The slow pace of progress has lead to a search for innovative responses, including social motivation approaches. One example of this type of approach is 'Community-led Total Sanitation' (CLTS). CLTS represents a major shift for sanitation projects and programmes in recognising the value of stopping open-defecation across the whole community, even when the individual toilets built are not necessarily wholly hygienic. However, recent publications on CLTS document a number of examples of practices which fail to meet basic ethical criteria and infringe human rights. There is a general theme in the CLTS literature encouraging the use of 'shame' or 'social stigma' as a tool for promoting behaviours. There are reported cases where monetary benefits to which individuals are otherwise entitled or the means to practice a livelihood are withheld to create pressures to conform. At the very extreme end of the scale, the investigation and punishment of violence has reportedly been denied if the crime occurred while defecating in the open, violating rights to a remedy and related access to justice. While social mobilisation in general, and CLTS in particular, have drastically and positively changed the way we think about sanitation, they neither need nor benefit from an association with any infringements of human rights.

  9. Why Won't You Drop, Damn YouZ? An Examination of the Targeting Process in Operation Enduring Freedom and its Implications

    National Research Council Canada - National Science Library

    Kindley, David

    2004-01-01

    ...?. This paper will examine the decision making process for rapid targeting in OEF from the strike fighter pilot through the watch officer in the Combined Air Operations Center at Prince Sultan Air Base...

  10. 'They won't change it back in their heads that we're trash': the intersection of sex work-related stigma and evolving policing strategies.

    Science.gov (United States)

    Krüsi, Andrea; Kerr, Thomas; Taylor, Christina; Rhodes, Tim; Shannon, Kate

    2016-09-01

    In Vancouver, Canada, there has been a continuous shift in the policing of sex work away from arresting sex workers, which led to the implementation of a policing strategy that explicitly prioritised the safety of sex workers and continued to target sex workers' clients. We conducted semi-structured interviews with 26 cisgender and five transgender women street-based sex workers about their working conditions. Data were analysed thematically and by drawing on concepts of structural stigma and vulnerability. Our results indicated that despite police rhetoric of prioritising the safety of sex workers, participants were denied their citizenship rights for police protection by virtue of their 'risky' occupation and were thus responsiblised for sex work related violence. Our findings further suggest that sex workers' interactions with neighbourhood residents were predominantly shaped by a discourse of sex workers as a 'risky' presence in the urban landscape and police took swift action in removing sex workers in the case of complaints. This study highlights that intersecting regimes of stigmatisation and criminalisation continued to undermine sex workers citizenship rights to police protection and legal recourse and perpetuated labour conditions that render sex workers at increased risk for violence and poor health. © 2016 Foundation for the Sociology of Health & Illness.

  11. “A Campaign Won as a Public Issue Will Stay Won”: Using Cartoons and Comics to Fight National Health Care Reform, 1940s and Beyond

    Science.gov (United States)

    Knoblauch, Heidi Katherine

    2014-01-01

    On March 23, 2010, President Barack Obama signed the Patient Protection and Affordable Care Act (ACA) into law. As it went through Congress, the legislation faced forceful resistance. Individuals and organizations opposing the ACA circulated propaganda that varied from photographs of fresh graves or coffins with the caption “Result of ObamaCare” to portrayals of President Obama as the Joker from the Batman movies, captioned with the single word “socialism.” The arguments embedded in these images have striking parallels to cartoons circulated by physicians to their patients in earlier fights against national health care. Examining cartoons used in the formative health care reform debates of the 1940s provides a means for tracing the lineage of emotional arguments employed against health care reform. PMID:24328659

  12. Can't do it, won't do it! Developing a theoretically framed intervention to encourage better decontamination practice in Scottish dental practices

    Directory of Open Access Journals (Sweden)

    Bonetti Debbie

    2009-06-01

    Full Text Available Abstract Background Guidance on the cleaning of dental instruments in primary care has recently been published. The aims of this study are to determine if the publication of the guidance document was enough to influence decontamination best practice and to design an implementation intervention strategy, should it be required. Methods A postal questionnaire assessing current decontamination practice and beliefs was sent to a random sample of 200 general dental practitioners. Results Fifty-seven percent (N = 113 of general dental practitioners responded. The survey showed large variation in what dentists self-reported doing, perceived as necessary or practical to do, were willing to do, felt able to do, as well as what they planned to change. Only 15% self-reported compliance with the five key guideline-recommended individual-level decontamination behaviours; only 2% reported compliance with all 11 key practice-level behaviours. The results also showed that our participants were almost equally split between dentists who were completely unmotivated to implement best decontamination practice or else highly motivated. The results suggested there was scope for further enhancing the implementation of decontamination guidance, and that an intervention with the greatest likelihood of success would require a tailored format, specifically targeting components of the theory of planned behaviour (attitude, perceived behavioural control, intention and implementation intention theory (action planning. Conclusion Considerable resources are devoted to encouraging clinicians to implement evidence-based practice using interventions with erratic success records, or no known applicability to a specific clinical behaviour, selected mainly by means of researchers' intuition or optimism. The methodology used to develop this implementation intervention is not limited to decontamination or to a single segment of primary care. It is also in accordance with the preliminary stages of the framework for evaluating complex interventions suggested by the medical research council. The next phases of this work are to test the intervention feasibility and evaluate its effectiveness in a randomised control trial.

  13. "I Won't Out Myself Just to Do a Survey": Sexual and Gender Minority Adolescents' Perspectives on the Risks and Benefits of Sex Research.

    Science.gov (United States)

    Macapagal, Kathryn; Coventry, Ryan; Arbeit, Miriam R; Fisher, Celia B; Mustanski, Brian

    2017-07-01

    Sexual and gender minority (SGM) adolescents under age 18 are underrepresented in sexual health research. Exclusion of SGM minors from these studies has resulted in a lack of knowledge about the risks and benefits youth experience from sexual health research participation. Institutional Review Boards' (IRB) overprotective stances toward research risks and requirements for guardian consent for SGM research are significant barriers to participation, though few have investigated SGM youth's perspectives on these topics. This study aimed to empirically inform decisions about guardian consent for sexuality survey studies involving SGM youth. A total of 74 SGM youth aged 14-17 completed an online survey of sexual behavior and SGM identity, and a new measure that compared the discomfort of sexual health survey completion to everyday events and exemplars of minimal risk research (e.g., behavioral observation). Youth described survey benefits and drawbacks and perspectives on guardian permission during an online focus group. Participants felt about the same as or more comfortable completing the survey compared to other research procedures, and indicated that direct and indirect participation benefits outweighed concerns about privacy and emotional discomfort. Most would not have participated if guardian permission was required, citing negative parental attitudes about adolescent sexuality and SGM issues and not being "out" about their SGM identity. Findings suggest that sexual health survey studies meet minimal risk criteria, are appropriate for SGM youth, and that recruitment would not be possible without waivers of guardian consent. Decreasing barriers to research participation would dramatically improve our understanding of sexual health among SGM youth.

  14. How the west was won: Charles Muskavitch, James Roth, and the arrival of ‘scientific’ art conservation in the western United States

    Directory of Open Access Journals (Sweden)

    Seth Adam Hindin

    2014-12-01

    Full Text Available This article examines the careers of the first two art conservators in North America active outside the north-eastern United States: Charles Muskavitch (1904–2001 and James Roth (1910–1990. Both men trained at the Fogg Art Museum at Harvard University during the 1930s as part of the initial cohort of modern, ‘scientific’ conservators, and remained professionally active into the 1970s. Muskavitch worked initially in Dallas, Texas, and then, from 1939 onward, in Sacramento, California; Roth spent his entire career in Kansas City, Missouri. It is argued that despite their pioneering contributions, they became peripheral to dominant narratives of conservation history because their modest social backgrounds and geographic distance from major institutions led them to be excluded from the powerful networks that developed among their Ivy League-educated contemporaries in the northeast, which continue to shape U.S. conservation up to the present.

  15. 'It's The Sun Wot Won It': Evidence of media influence on political attitudes and voting from a UK quasi-natural experiment.

    Science.gov (United States)

    Reeves, Aaron; McKee, Martin; Stuckler, David

    2016-03-01

    Do print media significantly impact political attitudes and party identification? To examine this question, we draw on a rare quasi-natural experiment that occurred when The Sun, a right-leaning UK tabloid, shifted its support to the Labour party in 1997 and back to the Conservative party in 2010. We compared changes in party identification and political attitudes among Sun readers with non-readers and other newspaper readerships. We find that The Sun's endorsements were associated with a significant increase in readers' support for Labour in 1997, approximately 525,000 votes, and its switch back was associated with about 550,000 extra votes for the Conservatives in 2010. Although we observed changes in readers' party preference, there was no effect on underlying political preferences. The magnitude of these changes, about 2% of the popular vote, would have been unable to alter the outcome of the 1997 General Election, but may have affected the 2010 Election. Copyright © 2015. Published by Elsevier Inc.

  16. We Made Your Bed, Why Won't You Lie in It? Food Availability and Disease May Affect Reproductive Output of Reintroduced Frogs.

    Directory of Open Access Journals (Sweden)

    Kaya Klop-Toker

    Full Text Available Mitigation to offset the impacts of land development is becoming increasingly common, with reintroductions and created habitat programs used as key actions. However, numerous reviews cite high rates of poor success from these programs, and a need for improved monitoring and scientific testing to evaluate outcomes and improve management actions. We conducted extensive monitoring of a released population of endangered green and golden bell frogs, Litoria aurea, within a created habitat, as well as complementary surveys of a surrounding wild population. We then compared differences between the created habitat and natural ponds where extant frogs either bred or didn't breed in order to determine factors that contributed to the breeding failure within the created habitat. We evaluated differences of L. aurea abundance, abundance of other fauna, vegetation, water quality, habitat structure, invasive fish, and disease between the three pond types (created habitat, breeding ponds, non-breeding ponds. We discovered that vegetation and invertebrate diversity were low within the created habitat, potentially reducing energy and nutritional resources required for breeding. Also, a greater proportion of frogs in the created habitat were carrying the chytrid fungal pathogen, Batrachochytrium dendrobatidis, compared to the wild populations. In addition to causing the potentially fatal disease, chytridiomycosis, this pathogen has been shown to reduce reproductive functioning in male L. aurea, and subsequently may have reduced reproductive activities in the created habitat. Conspecific attraction, pond hydrology, and aquatic vegetation may also have had some influence on breeding behaviours, whilst the presence of the invasive mosquitofish, Gambusia holbrooki, and heterospecific tadpoles were unlikely to have deterred L. aurea from breeding within the created habitat. Through the use of scientific testing and monitoring, this study is able to make recommendations for future amphibian breed and release programs, and suggests planting a diversity of plant species to attract invertebrates, creating some permanent ponds, connecting habitat with existing populations, trialling artificial mating calls, and following recommendations to reduce the prevalence of disease within the population.

  17. Won't get fooled again: why VW's emissions deception is illegal in Europe and how to improve the EU's auto regulatory system

    National Research Council Canada - National Science Library

    Tarsa, Kevin

    2017-01-01

    ... automakers to change their cars' performance settings before emissions tests. This Note argues that this regulation, though considered a loophole by some, is not an escape hatch for European car manufacturers. Thus, it argues that Volkswagen's use of defeat-device software violates EU law. With an eye toward preventing similar scandals in the future, it als...

  18. Distributed Leadership: A Good Theory but What if Leaders Won't, Don't Know How, or Can't Lead?

    Science.gov (United States)

    McKenzie, Kathryn Bell; Locke, Leslie Ann

    2014-01-01

    This article presents the results from an empirical qualitative study of the challenges faced by teacher leaders in their attempts to work directly with their colleagues to change instructional strategies and improve student success. Additionally, it offers a challenge to the utility of a naïvely espoused theory of distributed leadership, which…

  19. What girls won't do for love: human immunodeficiency virus/sexually transmitted infections risk among young African-American women driven by a relationship imperative.

    Science.gov (United States)

    Raiford, Jerris L; Seth, Puja; DiClemente, Ralph J

    2013-05-01

    Rates of Human immunodeficiency virus (HIV) and other sexually transmitted infections (STIs) continue to increase among African-American youth. Adolescents who have a stronger identity in relation to others (relational identity) rather than to themselves (self-identity) may view intimate relationships as imperative to a positive self-concept, which may lead to risky sexual behavior and abuse. Therefore, the present study assessed the associations among a relationship imperative and HIV/STI-related risk factors and behaviors. Participants were 715 African-American adolescent females, aged 15 to 21 years. They completed measures that assessed how important a relationship was to them and HIV-related risk factors and behaviors. Participants also provided vaginal swab specimens for STI testing. Multivariate logistic regression analyses, controlling for covariates, were conducted. Females who endorsed a relationship imperative (29%), compared to those who did not, were more likely to report: unprotected sex, less power in their relationships, perceived inability to refuse sex, anal sex, sex while their partner was high on alcohol/drugs, and partner abuse. Furthermore, participants with less power, recent partner abuse, and a perceived ability to refuse sex were more likely to test STI positive. These results indicate that if African-American adolescent females believe a relationship is imperative, they are more likely to engage in riskier sexual behaviors. Additionally, less perceived power and partner abuse increases their risk for STIs. HIV/STI prevention programs should target males and females and address healthy relationships, sense of self-worth, self-esteem and the gender power imbalance that may persist in the community along with HIV/STI risk. Published by Elsevier Inc.

  20. "The greatest victory which the chemist has won in the fight (…) against Nature": Nitrogenous fertilizers in Great Britain and the British Empire, 1910s-1950s.

    Science.gov (United States)

    Page, Arnaud

    2016-12-01

    This paper analyses the rise of synthetic nitrogen in Great Britain and its empire, from the First World War to the aftermath of the Second World War. Rather than focus solely on technological innovations and consumption statistics, it seeks to explain how nitrogen was a central element in the expansion of a form of agricultural governance, which needed simplified, stable, and seemingly universal input/output formulae. In the first half of the twentieth century, nitrogen was thus gradually constructed as a global indicator of development, as it was particularly adapted to scientific and political regimes increasingly relying upon abstraction and quantification. Yet, the history of nitrogenous fertilizers in the interwar years also shows that this cannot be reduced to a simple story of triumphant modernity, as their development and globalization was imperfect, unstable, accompanied by resistance and the resilience or emergence of other models. Rather than assuming an all-powerful "state" project, the paper thus seeks to recover the multiplicity of actors, and attempts to account for the rise of nitrogenous fertilizers; not just as the progressive application of a technological breakthrough, but as a difficult process embedded in technological, financial, and military constraints, corporate strategies, political imperatives, and the changing institutional framework of agricultural research.

  1. Secrets of the Super Net Searchers: The Reflections, Revelations, and Hard-Won Wisdom of 35 of the World's Top Internet Researchers.

    Science.gov (United States)

    Basch, Reva

    This book presents the collected wisdom of 35 leading Internet hunters and gatherers. Through interviews, these experts offer insights, anecdotes, tips, techniques, and case histories which will raise the "searching IQ" of any serious Internet user. The Super Net Searchers explain how they find valuable information on the Internet,…

  2. "I Won't Trust You if I Think You're Trying to Deceive Me": Relations between Selective Trust, Theory of Mind, and Imitation in Early Childhood

    Science.gov (United States)

    DiYanni, Cara; Nini, Deniela; Rheel, Whitney; Livelli, Alicia

    2012-01-01

    This study explores connections between 3-, 4-, and 5-year-olds' performance in theory-of-mind tasks, their performance on an assessment of selective trust, and their decisions to (not) imitate the questionable tool choices of an adult model. The prediction was that all the tasks would be related, with improvements in theory of mind and selective…

  3. Where do we go from here Now that some utilities have won the incentive regulation war, many executives are wondering how they can manage the peace

    Energy Technology Data Exchange (ETDEWEB)

    Christensen, L.R.; Meitzen, M.E.; Schoech, P.E.

    1993-06-15

    Productivity is a measure of how efficiently a company uses its resources. The productivity budgeting model (PBM) is one tool that can aid management in the transition from cost-plus, rate-of-return regulation to the market-oriented, cost-control environment of incentive regulation. Most, if not all, utilities use some type of budgeting/forecasting process that provides the blueprint for future company activity. The PBM reveals the growth in total factor productivity (TFP) implied by a budget and, thus, provides a forecast of the company's future efficiency. The PBM can be used to guide resource usage, because it analyzes investment, labor force, and operating decisions from an economic efficiency perspective. In general, the model makes the budgeting process more relevant to the kind of decisions utility management must make for long-term success under incentive regulation. Furthermore, under many incentive regulation. Furthermore, under many incentive regulation plans (such as the FCC's price-cap plan), a company must meet or beat the productivity offset to increase its profitability. With PBM, the company can determine whether its proposed budget is on track and devise a plan to meet any offset. The PBM can also be used to track productivity using financial data from the period in question.

  4. Why I Force My Students to Memorize Poetry: Despite the Fact that It Won't Be on the Standardized Test

    Science.gov (United States)

    Waddell, Andy

    2011-01-01

    So often teachers see education as a series of units leading to an examination, which will in turn prepare students for the SATs or APs they need to pass to enter university where, if they pass other examinations, they will graduate and earn large incomes. Teachers hold those future earnings before their students like a carrot while beating them…

  5. "No one's at home and they won't pick up the phone": using the Internet and text messaging to enhance partner services in North Carolina.

    Science.gov (United States)

    Hightow-Weidman, Lisa; Beagle, Steve; Pike, Emily; Kuruc, Joann; Leone, Peter; Mobley, Victoria; Foust, Evelyn; Gay, Cynthia

    2014-02-01

    The Internet and mobile devices are increasingly used by men who have sex with men to find potential partners. Lack of partner information, besides e-mail addresses or user profiles, limits the ability to adequately perform partner notification by traditional means and test those at high risk. To streamline North Carolina Internet Partner Notification (IPN) services, University of North Carolina at Chapel Hill collaborated with the North Carolina Division of Public Health beginning in July 2011 to formalize state IPN and text messaging for partner notification (txtPN) policies and centralize notification practices by designating a single IPN/txtPN field coordinator within the University of North Carolina at Chapel Hill. We compared the number of IPN and txtPN contacts initiated and their outcomes in July 1, 2011, to June 30, 2012, and compared with outcomes in January 1, 2010, to December 31, 2010, the year before the collaboration. Overall, 362 IPN contacts were initiated compared with 133 initiated in 2010. More than half (59.1%) were black; mean age was 28.8 years. Almost all were men who have sex with men (83.7%). Approximately two-thirds (n = 230; 63.5%) of contacts were successfully notified using centralized IPN. Seven new cases of HIV infection, 11 new cases of syphilis, and 19 known previous HIV-positive persons were identified. Text messaging for partner notification was used for 29 contacts who did not initially respond to traditional notification or IPN; 14 (48%) responded to txtPN in a median time of 57.5 minutes (interquartile range, 9-2708). Centralization of IPN services augmented partner detection of new HIV and syphilis diagnoses. Text messaging for partner notification represents a potentially effective method for augmenting traditional partner services. In addition, IPN and txtPN allow identification of HIV-infected persons in need of linkage to care.

  6. Why won't they sit with me? An exploratory investigation of stereotyped cues, social exclusion, and the P3b.

    Science.gov (United States)

    Kiat, John E; Straley, Elizabeth; Cheadle, Jacob E

    2017-10-01

    The importance of understanding how we anticipate and prepare for being socially excluded is underscored by the numerous adverse mental and physical consequences of social rejection. In this study, we adapted a social exclusion paradigm, the Lunchroom task, to investigate the use of social context cues in the formation of social outcome expectations as indexed by the P3b, an ERP component associated with attention orientation and context updating. In this task, Black and White participants were presented with either neutral or stereotyped cues prior to being exposed to simulated inclusion versus exclusion outcome scenarios. Black participants showed evidence of (1) a significantly reduced P3b response to exclusions preceded by stereotyped cues relative to neutral cue-related exclusions and (2) a marginally significant increase in the P3b response to inclusions relative to exclusions when both were preceded by stereotyped cues. Both of these findings suggest a key role for the use of social cues in the formation of outcome expectations. In line with our hypothesis that the random intermixing of inclusion and exclusion outcomes would prevent formation of outcome expectations when coupled with the absence of self-relevant cues, no overall P3b modulations were observed among a comparison group of White participants.

  7. When Multiplication Facts Won't Stick: Could a Language/Story Approach Work? A Research Study Examining the Effectiveness of the "Memorize in Minutes" Curriculum

    Science.gov (United States)

    Mahler, Joni D.

    2011-01-01

    This study examined whether a story/language based method of teaching the multiplication facts would be helpful to students who previously had difficulty with the memorization of those facts. Using the curriculum "Memorize in Minutes" by Alan Walker (Walker, 2000), the researcher taught six fourth-grade students the multiplication facts (3s…

  8. I won't let you down... or will I? Core self-evaluations, other-orientation, anticipated guilt and gratitude, and job performance.

    Science.gov (United States)

    Grant, Adam M; Wrzesniewski, Amy

    2010-01-01

    Although core self-evaluations have been linked to higher job performance, research has shown variability in the strength of this relationship. We propose that high core self-evaluations are more likely to increase job performance for other-oriented employees, who tend to anticipate feelings of guilt and gratitude. We tested these hypotheses across 3 field studies using different operationalizations of both performance and other-orientation (prosocial motivation, agreeableness, and duty). In Study 1, prosocial motivation strengthened the association between core self-evaluations and the performance of professional university fundraisers. In Study 2, agreeableness strengthened the association between core self-evaluations and supervisor ratings of initiative among public service employees. In Study 3, duty strengthened the association between core self-evaluations and the objective productivity of call center employees, and this moderating relationship was mediated by feelings of anticipated guilt and gratitude. We discuss implications for theory and research on personality and job performance. Copyright 2009 APA, all rights reserved.

  9. "I Won't Talk about This Here in America": Sociocultural Context of Korean English Language Learners' Emotion Speech in English

    Science.gov (United States)

    Kim, Sujin; Dorner, Lisa M.

    2013-01-01

    This article examines the relationship between language and emotion, especially drawing attention to the experiences and perspectives of second language (SL) learners. Informed by the sociocultural perspective on the construction of emotion and its representation, this study highlights the intertwined relationship among emotions, cultural…

  10. When the Cat Is Near, the Mice Won't Play: The Effect of External Examiners in Italian Schools. CEP Discussion Paper No. 1191

    Science.gov (United States)

    Bertoni, Marco; Brunello, Giorgio; Rocco, Lorenzo

    2013-01-01

    We use a natural experiment to show that the presence of an external examiner has both a direct and an indirect negative effect on the performance of monitored classes in standardized educational tests. The direct effect is the difference in the test performance between classes of the same school with and without external examiners. The indirect…

  11. What if You Build It and They Still Won't Come? Addressing Student Awareness of Resources and Services with Promotional Videos

    Science.gov (United States)

    Dalal, Heather A.; Lackie, Robert J.

    2014-01-01

    After a needs assessment exposed that even daily library users were unaware of the best resources, tools, and services, the Rider University Libraries switched gears from a focus on the creation of long step-by-step tutorials, to the creation of short promotional videos for all users, with attention on the needs of distance learners. This project…

  12. "If you don't believe it, it won't help you": use of bush medicine in treating cancer among Aboriginal people in Western Australia

    Directory of Open Access Journals (Sweden)

    Bessarab Dawn

    2010-06-01

    Full Text Available Abstract Background Little is known about the use of bush medicine and traditional healing among Aboriginal Australians for their treatment of cancer and the meanings attached to it. A qualitative study that explored Aboriginal Australians' perspectives and experiences of cancer and cancer services in Western Australia provided an opportunity to analyse the contemporary meanings attached and use of bush medicine by Aboriginal people with cancer in Western Australia Methods Data collection occurred in Perth, both rural and remote areas and included individual in-depth interviews, observations and field notes. Of the thirty-seven interviews with Aboriginal cancer patients, family members of people who died from cancer and some Aboriginal health care providers, 11 participants whose responses included substantial mention on the issue of bush medicine and traditional healing were selected for the analysis for this paper. Results The study findings have shown that as part of their healing some Aboriginal Australians use traditional medicine for treating their cancer. Such healing processes and medicines were preferred by some because it helped reconnect them with their heritage, land, culture and the spirits of their ancestors, bringing peace of mind during their illness. Spiritual beliefs and holistic health approaches and practices play an important role in the treatment choices for some patients. Conclusions Service providers need to acknowledge and understand the existence of Aboriginal knowledge (epistemology and accept that traditional healing can be an important addition to an Aboriginal person's healing complementing Western medical treatment regimes. Allowing and supporting traditional approaches to treatment reflects a commitment by modern medical services to adopting an Aboriginal-friendly approach that is not only culturally appropriate but assists with the cultural security of the service.

  13. Key opinion leaders and the corruption of medical knowledge: what the Sunshine Act will and won't cast light on.

    Science.gov (United States)

    Sismondo, Sergio

    2013-01-01

    The pharmaceutical industry, in its marketing efforts, often turns to "key opinion leaders" or "KOLs" to disseminate scientific information. Drawing on the author's fieldwork, this article documents and examines the use of KOLs in pharmaceutical companies' marketing efforts. Partly due to the use of KOLs, a small number of companies with well-defined and narrow interests have inordinate influence over how medical knowledge is produced, circulated, and consumed. The issue here, as in many other cases of institutional corruption, is that a few actors have accumulated the power to shape the information on which many others base their decisions. Efforts to address this corruption should focus on correcting large imbalances in the current political economy of medical knowledge. A sequestration of pharmaceutical research and development on one hand from pharmaceutical marketing on the other, though difficult to achieve, would address this and many other problems. © 2013 American Society of Law, Medicine & Ethics, Inc.

  14. "Won't Somebody 'Think' of the Children?" Emotions, Child Poverty, and Post-Humanitarian Possibilities for Social Justice Education

    Science.gov (United States)

    Jackson, Liz

    2014-01-01

    Under models of moral and global citizenship education, compassion and caring are emphasized as a counterpoint to pervasive, heartless, neo-liberal globalization. According to such views, these and related emotions such as empathy, sympathy, and pity, can cause people to act righteously to aid others who are disadvantaged through no fault of their…

  15. Hyperosmotic stress induces Rho/Rho kinase/LIM kinase-mediated cofilin phosphorylation in tubular cells: key role in the osmotically triggered F-actin response

    DEFF Research Database (Denmark)

    Thirone, Ana C P; Speight, Pam; Zulys, Matthew

    2009-01-01

    ) dominant negative (DN) Rho and DN-ROCK, but not DN-Rac and DN-PAK inhibited cofilin phosphorylation; b) constitutively active (CA) Rho and CA-ROCK but not CA-Rac and CA-PAK induced cofilin phosphorylation; c) hyperosmolarity induced LIMK-2 phosphorylation, and d) inhibition of ROCK by Y-27632 suppressed...

  16. Óleo essencial de limão no ensino da cromatografia em camada delgada Lime essential oil in the teaching of thin layer chromatography

    Directory of Open Access Journals (Sweden)

    Rosaly S. Silva

    2009-01-01

    Full Text Available This paper describes a simple experiment employing the essential oil of limes which can be applied in undergraduate organic chemistry laboratory classes for the teaching of thin layer chromatography (TLC. The experiment consists in submit lime peel oil to TLC separation employing hexane and dichloromethane as the eluents and five different systems for visualization of the chromatogram. In one experiment it is possible to teach the different variables of the TLC technique. This experiment may also be performed following vapor distillation and liquid-liquid extraction technique in experimental classes.

  17. Tatwir al-ta'lim al-zira'i fi al-jumhuriyah al-'arabiyah al-muttahidah (Development of Agricultural Education in the UAR).

    Science.gov (United States)

    Ministry of Education, Cairo (United Arab Republic).

    This document is an English-language abstract (approximately 1,500 words) of a publication concerned with the recent developments in agricultural education resulting from the application of socialist principles in the UAR. The preface discusses the present conditions of vocational education and the essential role it can play in the development of…

  18. Mammalia, Chiroptera, Emballonuridae, Peropteryx leucoptera Peters, 1867 and Peropteryx pallidoptera Lim, Engstrom, Reid, Simmons, Voss and Fleck, 2010: Distributional range extensions in Ecuador

    Directory of Open Access Journals (Sweden)

    McDonough, M. M.

    2010-01-01

    Full Text Available We reevaluate vouchered records of Peropteryx leucoptera in Ecuador with regard to the morphologicallysimilar and newly described species, P. pallidoptera. The western-most distributional occurrence of P. pallidoptera isdocumented. Additionally, we describe a new record of P. leucoptera collected at Palma Roja, Cuyabeno Faunistic Reserve inSucumbíos Province, Ecuador that represents the first record for this species in Sucumbíos Province and the northern-mostdistributional occurrence for Ecuador.

  19. Normas Dris para Porta-Enxertos Limão Cravo e Citrumelo Swingle / Dris Norms for Rangpur Lime and Swingle Citrumelo Rootstock

    Directory of Open Access Journals (Sweden)

    Cláudia Fabiana Alves Rezende

    2017-04-01

    Full Text Available Objective of obtaining a foliar analysis database to establish the DRIS and assess the nutritional status of two rootstocks (Rangpur Lime and Swingle Citrumelo. Collections were made of 180 samples of leaves for each rootstock. The database was analyzed by the method of critical levels or concentration ranges and by DRIS methodology. The Concentration ranges diagnosed, to the Lemon rootstock Harpsichord, the nutrients limiting deficiency were more Mg and Zn and excess P and Fe. For the Swingle Citrumelo, by limiting disabilities K, S, Mn, Cu and Zn and excess Fe and Zn is the nutrient most often of deficiency and excess Fe between rootstocks. The DRIS method diagnosed the S as the most limiting and deficiency as the most limiting for excess. The method offers greater sensitivity to diagnose nutritional problems.

  20. Jovens e experimentações da violência no brasil: estética da destruição, sociabilidades limítrofes

    Directory of Open Access Journals (Sweden)

    Rosamaria Luiza de Melo Rocha

    2000-10-01

    Full Text Available El artículo aborda algunos fenómenos de violencia en ciudades brasileñas, desde un punto de vista comunicacional; la autora logra identificar intersecciones entre ellos, particularmente frente a aspectos de visibilidad, construcción de identidad y sociabilidad que involucran a jóvenes urbanos.Buscando sintetizar reflexiones acerca de ciertas ocurrencias de la violencia –acto social y simbólico- en tal contexto, centra su preocupación en la experimentación de una “cultura do risco” – desafiante, personalista y a veces letal.Propone, además, que la violencia se manifiesta y puede ser percibida bajo un proceso dinámico y dialógico fundado en originales ordenaciones sociales y visuales. Postula, finalmente, que la violencia hoy constituye un poderoso lenguaje, una pedagogía percibida e “incorporada” por diversos sectores juveniles.Este por demás inquietante componente de la comunicación urbana, termina poniendo en evidencia lugares de construcción identitaria a veces tensionados y explosivos, a veces estetizados, poéticos, demarcados por la creciente simbiosis media/sociedad, por la vivencia de los media en cuanto nuevo espacio público y de las ciudades en cuanto peculiares escenarios y focos preferenciales de la visibilidadmediatizada.The article approaches the phenomena of violence in Brazilian cities from a communicational perspective; the author is able to identify intersections between these phenomena, particularly what they have to do with aspects of visibility and construction of identity and sociability as these concepts relate to urban youth.Looking to summarize reflections about certain occurences of violence — a social and symbolic act –- in that context, the author focuses her concern on the experimentation of a “culture of risk,” which is challenging, personalist, and sometimes lethal.In addition, she proposes that violence manifests itself and can be perceived in a dynamic and dialogic process founded on original social and visual orderings. Finally, she postulates that violence today constitutes a powerful language, a pedagogy perceived and “incorporated” by diverse sectors of youth.This very perturbing component of urban communication shows places of construction of identity that are sometimes tense and explosive, sometimes aesthetized, poetic, delimited by the growing media-society symbiosis, by personal experience with the media as a new public space and the cities as peculiar scenarios and preferential focuses of mass media visibility.

  1. Täna on ülim aeg Eestile öelda, et ta on armastamist väärt / Arnold Rüütel

    Index Scriptorium Estoniae

    Rüütel, Arnold

    2001-01-01

    Ilmunud ka Estonija (2001/Oct/10) lk. 2 (lüh.) ; ERL Teataja (2001/Oct) nr.10, lk. 2 ; Raamatus "President". -Tallinn, 2003, lk. 24-29, pealkiri: Eesti iseseisvuse tagatised on riigi ja rahvuslikus eneseväärikuses. President Arnold Rüütli kõne Riigikogus ametisse astumise tseremoonial

  2. Reduced corporal fibrosis to protect erectile function by inhibiting the Rho-kinase/LIM-kinase/cofilin pathway in the aged transgenic rat harboring human tissue kallikrein 1

    Directory of Open Access Journals (Sweden)

    Kai Cui

    2017-01-01

    Full Text Available Our previous studies have demonstrated that erectile function was preserved in aged transgenic rats (TGR harboring the human tissue kallikrein 1 (hKLK1, while the molecular level of hKLK1 on corporal fibrosis to inhibit age-related erectile dysfunction (ED is poorly understood. Male wild-type Sprague-Dawley rats (WTR and TGR harboring the hKLK1 gene were fed to 4- or 18-month-old and divided into three groups: young WTR (yWTR as the control, aged WTR (aWTR, and aged TGR (aTGR. Erectile function of all rats was assessed by cavernous nerve electrostimulation method. Masson′s trichrome staining was used to evaluate corporal fibrosis in the corpus cavernosum. We found that the erectile function of rats in the aWTR group was significantly lower than that of other two groups. Masson′s trichrome staining revealed that compared with those of the yWTR and aTGR groups, the ratio of smooth muscle cell (SMC/collagen (C was significantly lower in the aWTR group. Immunohistochemistry and Western blotting analysis were performed, and results demonstrated that expression of α-SMA was lower, while expressions of transforming growth factor-β 1 (TGF-β1, RhoA, ROCK1, p-MYPT1, p-LIMK2, and p-cofilin were higher in the aWTR group compared with those in other two groups. However, LIMK2 and cofilin expressions did not differ among three groups. Taken together, these results indicated that the RhoA/ROCK1/LIMK/cofilin pathway may be involved in the corporal fibrosis caused by advanced age, and hKLK1 may reduce this corporal fibrosis by inhibiting the activation of this pathway to ameliorate age-related ED.

  3. ‘AMALIYYAH TA’LIM HIFDH AL-MUFRADAT BI WASITHAH AL-UGHNIYAH LI TARJAMAH KUTUB AT-TURATS

    Directory of Open Access Journals (Sweden)

    Miftahul Ula

    2017-04-01

    Full Text Available The basic concept of Arabic language learning is learning kinds of noun. Therefore, it is necessary for Arabic language learners to know the name of things needed in communication. One of the causes of failure and success in language learning is the use of media. There are so many teaching media used in language learning, including songs. In this case, the teacher chooses the most favorite song of the students, and then changes its lyrics with difficult words of the classic book. This media is used because it is supposed to be able to create fun and enjoyable situation and give the students ease in memorizing new vocabularies, especially in understanding the meaning of the classic books. On the other hand, the weakness of this media is that the teacher, especially those who have lack of singing abilities, found any difficulties in preparing the vocabulary of the classic book and put them into the song lyrics.

  4. AL-'ALAQAH BAINA TAQSIM AL-SHAF AL-DIRASIY WA INJAZ AL-TALAMIDZ FI TA'LIM AL-LUGHAH AL-'ARABIYAH

    Directory of Open Access Journals (Sweden)

    Muhammad Ridha

    2016-12-01

    Full Text Available This research was aimed to identify the relation between classroom classification based on the cognitive level and students’ achievement in learning Arabic language. The method used in this research was quantitative using the samples all the 8th grade of MTsN 2 Jagakarsa, 50 students academic year 2012/2013. The research found that there was no relationship between classifying students based on their cognitive level and their achievement in Arabic language with the value (-0,130. This value is between (0,00 – 0,20 meaning that there is no correlation between those two variables. It means that the alternative hypothesis (Ha was rejected and the null hypothesis (Ho was accepted or there was no relationship between the variables. DOI: 10.24865/ajas.v1i2.14

  5. Inclusión de la Población Indígena Bribri y Cabécar en la Sede Limón

    OpenAIRE

    Alpízar Pereira, Leyla; Artiaga Artiaga, Flor

    2011-01-01

    El presente artículo tiene como objetivo hacer una revisión en torno a la situación de la población indígena de Talamanca en la actualidad y proponer estrategias que faciliten su inclusión en el sistema de educación superior de la Universidad de Costa Rica. Lo anterior, por medio de acciones de promoción y acompañamiento en cada una de las fases del proceso de admisión, ingreso y permanencia dentro de la universidad. Esta propuesta se considera de importancia partiendo del prin...

  6. El manejo institucional y percepción de la población en el Terremoto de Limón

    OpenAIRE

    Bermúdez, Marlen

    2011-01-01

    La cuenca caribeña de Costa Rica fue sacudida por un gran terremoto (Ms= 7,5) el 22 de abril de 1991. Las autoridades de protección civil se vieron envueltas en el manejo de un desastre natural mayor, sin poseer un adecuado plan maestro para el manejo de una emergencia de esta envergadura. Tampoco se contaba con un planeamiento ni un sistema de información apropiados. Esta falta de políticas de manejo de emergencias generó duplicidad, desorden, fricción y confusión entre el Gobierno Central, ...

  7. Estudio del comportamiento de hormonas vegetales y nutrientes durante el crecimiento y maduraci??n del lim??n (Citrus limonum Risso, cv. Verna)

    OpenAIRE

    Valero Garrido, Daniel

    1993-01-01

    Se ha estudiado el efecto de tratamientos ex??genos con ga3 y kinetina sobre el comportamiento de aba (t-aba y aba) y ga3 tanto en frutos como en hojas de limonero verna a lo largo de su ciclo vegetativo. Ambos tratamientos han llevado a una menor abscisi??n de frutos, uno de los principales problemas de este cultivo, debido al mayor contenido de ga3 durante el periodo de fijaci??n, a la tendencia descendente de los dos is??meros del aba y a la mayor acumulaci??n de prote??nas totales y nutri...

  8. Effect of Geophila macropoda (Rubiaceae) as “weed cover” on hydric erosion in banana plantations, Guápiles , Limón , Costa Rica.

    OpenAIRE

    Murillo, Jimmy; Méndez-Estrada +, Víctor Hugo; Brenes Prendas, Steven

    2016-01-01

    The establishment of banana companies in Costa Rica brought employment and infrastructure improvements, but also social problems, destruction of forests, soil erosion and pollution of rivers and streams. Erosion in banana plantations may be diminished with plant cover. Here we analyze the effect of the plant Geophila macropoda on erosion caused by water in Guápiles, Costa Rica. We chose three soil classes I, II and III with and without G. macropoda. Between June and August 2012 periodic measu...

  9. ANALISIS PENGARUH PENDAPATAN TERHADAP JUMLAH INFAQ PESERTA PENGAJIAN ROHANI Studi Kasus Majelis Ta’lim di Masjid Al-Aman, Sidoarum, Godean, Sleman

    Directory of Open Access Journals (Sweden)

    Zein Muttaqin

    2015-12-01

    Full Text Available Nowadays, there are growing religious study community that urges people to deepen religious teachings. This community appears as learning, warning and preparation  forum  to  face  trial  in  the  after  life.  It  is  assumed  that  by  following religious  community,  people  will  improved  their  understanding  about  religious teachings that will affected their life behavior. The purpose of this research is to analyze  the  effect  of  intensity  to  attend  religious  community,  income  and comprehension  toward  the  infaq  of  attendee  of  religious  community  and  to explain the infaq behavior of attendant of religious community. This  field  research  is  a  quantitative  research.  There  are  50  samples  that used in this research which consists by ladies. In this research, the writer is using primary  data  that  procured  by  questionnaire  distributions.  The  data  analysis technique  that  used  in  this  research  are  descriptive  data  analysis  and  multiple regression  analysis.  As  for  the  hypothesis  that  suggested  in  this  research  is  that intensity to attend religious community, income and comprehension are affecting the infaq of attendee of religious community. The  result  of  this  research  shows  that  intensity  to  attend  religious community (not affecting, income (affecting and comprehension (not affecting toward the infaq of attendee of religious community. Most of behavior that shown in this research is unconsciously by attendee as manifestation form God words in the  Quran  and  Sunnah.  Intensity,  income  and  comprehension  variables  are affecting  only  38,9  percent,  whereas  61,1  percent  is  affected  by  other  variables outside this research.

  10. Reduced corporal fibrosis to protect erectile function by inhibiting the Rho-kinase/LIM-kinase/cofilin pathway in the aged transgenic rat harboring human tissue kallikrein 1

    Science.gov (United States)

    Cui, Kai; Luan, Yang; Wang, Tao; Zhuan, Li; Rao, Ke; Wang, Shao-Gang; Ye, Zhang-Qun; Liu, Ji-Hong; Wang, Dao-Wen

    2017-01-01

    Our previous studies have demonstrated that erectile function was preserved in aged transgenic rats (TGR) harboring the human tissue kallikrein 1 (hKLK1), while the molecular level of hKLK1 on corporal fibrosis to inhibit age-related erectile dysfunction (ED) is poorly understood. Male wild-type Sprague-Dawley rats (WTR) and TGR harboring the hKLK1 gene were fed to 4- or 18-month-old and divided into three groups: young WTR (yWTR) as the control, aged WTR (aWTR), and aged TGR (aTGR). Erectile function of all rats was assessed by cavernous nerve electrostimulation method. Masson's trichrome staining was used to evaluate corporal fibrosis in the corpus cavernosum. We found that the erectile function of rats in the aWTR group was significantly lower than that of other two groups. Masson's trichrome staining revealed that compared with those of the yWTR and aTGR groups, the ratio of smooth muscle cell (SMC)/collagen (C) was significantly lower in the aWTR group. Immunohistochemistry and Western blotting analysis were performed, and results demonstrated that expression of α-SMA was lower, while expressions of transforming growth factor-β 1 (TGF-β1), RhoA, ROCK1, p-MYPT1, p-LIMK2, and p-cofilin were higher in the aWTR group compared with those in other two groups. However, LIMK2 and cofilin expressions did not differ among three groups. Taken together, these results indicated that the RhoA/ROCK1/LIMK/cofilin pathway may be involved in the corporal fibrosis caused by advanced age, and hKLK1 may reduce this corporal fibrosis by inhibiting the activation of this pathway to ameliorate age-related ED. PMID:27678468

  11. Lim Mineralization Protein 3 Induces the Osteogenic Differentiation of Human Amniotic Fluid Stromal Cells through Kruppel-Like Factor-4 Downregulation and Further Bone-Specific Gene Expression

    Directory of Open Access Journals (Sweden)

    Marta Barba

    2012-01-01

    Full Text Available Multipotent mesenchymal stem cells with extensive self-renewal properties can be easily isolated and rapidly expanded in culture from small volumes of amniotic fluid. These cells, namely, amniotic fluid-stromal cells (AFSCs, can be regarded as an attractive source for tissue engineering purposes, being phenotypically and genetically stable, plus overcoming all the safety and ethical issues related to the use of embryonic/fetal cells. LMP3 is a novel osteoinductive molecule acting upstream to the main osteogenic pathways. This study is aimed at delineating the basic molecular events underlying LMP3-induced osteogenesis, using AFSCs as a cellular model to focus on the molecular features underlying the multipotency/differentiation switch. For this purpose, AFSCs were isolated and characterized in vitro and transfected with a defective adenoviral vector expressing the human LMP3. LMP3 induced the successful osteogenic differentiation of AFSC by inducing the expression of osteogenic markers and osteospecific transcription factors. Moreover, LMP3 induced an early repression of the kruppel-like factor-4, implicated in MSC stemness maintenance. KLF4 repression was released upon LMP3 silencing, indicating that this event could be reasonably considered among the basic molecular events that govern the proliferation/differentiation switch during LMP3-induced osteogenic differentiation of AFSC.

  12. ‘They won't change it back in their heads that we're trash’: the intersection of sex work‐related stigma and evolving policing strategies

    National Research Council Canada - National Science Library

    Krüsi, Andrea; Kerr, Thomas; Taylor, Christina; Rhodes, Tim; Shannon, Kate

    2016-01-01

    In Vancouver, Canada, there has been a continuous shift in the policing of sex work away from arresting sex workers, which led to the implementation of a policing strategy that explicitly prioritised...

  13. The Family Smoking Prevention and Tobacco Control Act and the First Amendment: why a substantial interest in protecting public health won't save some new restrictions on tobacco advertising.

    Science.gov (United States)

    Stoll, Elaine

    2010-01-01

    Congress passed the Family Smoking Prevention and Tobacco Control Act in 2009 with the aim of reducing tobacco-related illnesses and deaths by curbing tobacco's appeal to and use by children and adolescents. Legislators considered provisions of the FSPTCA restricting tobacco advertising and labeling key to realizing the law's intended health benefits. But a lawsuit now before the U.S. Court of Appeals for the Sixth Circuit challenges the tobacco marketing restrictions as impermissible restraints on tobacco companies' commercial speech rights under the First Amendment. This article analyzes the constitutionality of each FSPTCA tobacco advertising and labeling restriction in light of U.S. Supreme Court decisions defining the extent of First Amendment protection for commercial speech, prior efforts to restrict tobacco marketing, and the outcomes of legal challenges to some of the prior marketing restrictions. Several of the FSPTCA tobacco advertising and labeling restrictions were drafted with insufficient accommodations for tobacco companies' First Amendment right to convey and consumers' First Amendment right to receive truthful information about lawful tobacco products and are therefore unconstitutional as currently written.

  14. 'One sip won't do any harm . . .': temptation among women with inflammatory bowel disease/irritable bowel syndrome to engage in negative dietary behaviours, despite the consequences to their health.

    Science.gov (United States)

    Schneider, Margaret A; Jamieson, Anne; Fletcher, Paula C

    2009-04-01

    The purpose of this research was to explore the dietary lived experiences of university-aged women suffering from inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS). This paper will address the decision-making process used by these women when contemplating the consumption of dietary temptations, despite the associated negative consequences. This phenomenological study was guided by heuristic inquiry. A purposive sample of eight women, between the ages of 18 and 23 years, who were living with IBD or IBS were recruited via postings and word-of-mouth. The findings indicate that these women occasionally felt compelled to give into dietary temptations, despite the consequences to their health. The decision-making process they used when considering these negative health behaviours involved three personally controlled parameters. These three parameters included: assessing the cost-benefit relationship before engaging in these behaviours; having a physical and/or psychological reliance on medications to treat resulting symptoms; and through controlling the timing and surroundings in which they indulged in these negative dietary behaviours. The practical implications for health-care professionals treating patients with IBD or IBS are discussed.

  15. 1:0 for Spain. After the soccer World Championship, Spain won an important solar contest in South Africa; 1:0 fuer Spanien. Nach der Fussball-WM hat Spanien in Suedafrika nun einen wichtigen Solarwettbewerb gewonnen

    Energy Technology Data Exchange (ETDEWEB)

    Rosell, Alejandro Diego; Mattke, Sascha

    2012-03-15

    Spanish manufacturers acquired more orders for construction of industrial-scale PV systems in South Africa than their competitors from other countries. German manufacturers managed to get contracts as partners in several projects.

  16. We'll Be Honest, This Won't Be the Best Article You'll Ever Read: The Use of Dispreferred Markers in Word-of-Mouth Communication

    OpenAIRE

    Ryan Hamilton; Kathleen D. Vohs; Ann L. McGill

    2014-01-01

    Consumers value word-of-mouth communications in large part because customer reviews are more likely to include negative information about a product or service than are communications originating from the marketer. Despite the fact that negative information is frequently valued by those receiving it, baldly declaring negative information may come with social costs to both communicator and receiver. For this reason, communicators sometimes soften pronouncements of bad news by couching them in d...

  17. When whole-genome alignments just won't work: kSNP v2 software for alignment-free SNP discovery and phylogenetics of hundreds of microbial genomes.

    Directory of Open Access Journals (Sweden)

    Shea N Gardner

    Full Text Available Effective use of rapid and inexpensive whole genome sequencing for microbes requires fast, memory efficient bioinformatics tools for sequence comparison. The kSNP v2 software finds single nucleotide polymorphisms (SNPs in whole genome data. kSNP v2 has numerous improvements over kSNP v1 including SNP gene annotation; better scaling for draft genomes available as assembled contigs or raw, unassembled reads; a tool to identify the optimal value of k; distribution of packages of executables for Linux and Mac OS X for ease of installation and user-friendly use; and a detailed User Guide. SNP discovery is based on k-mer analysis, and requires no multiple sequence alignment or the selection of a single reference genome. Most target sets with hundreds of genomes complete in minutes to hours. SNP phylogenies are built by maximum likelihood, parsimony, and distance, based on all SNPs, only core SNPs, or SNPs present in some intermediate user-specified fraction of targets. The SNP-based trees that result are consistent with known taxonomy. kSNP v2 can handle many gigabases of sequence in a single run, and if one or more annotated genomes are included in the target set, SNPs are annotated with protein coding and other information (UTRs, etc. from Genbank file(s. We demonstrate application of kSNP v2 on sets of viral and bacterial genomes, and discuss in detail analysis of a set of 68 finished E. coli and Shigella genomes and a set of the same genomes to which have been added 47 assemblies and four "raw read" genomes of H104:H4 strains from the recent European E. coli outbreak that resulted in both bloody diarrhea and hemolytic uremic syndrome (HUS, and caused at least 50 deaths.

  18. When whole-genome alignments just won't work: kSNP v2 software for alignment-free SNP discovery and phylogenetics of hundreds of microbial genomes.

    Science.gov (United States)

    Gardner, Shea N; Hall, Barry G

    2013-01-01

    Effective use of rapid and inexpensive whole genome sequencing for microbes requires fast, memory efficient bioinformatics tools for sequence comparison. The kSNP v2 software finds single nucleotide polymorphisms (SNPs) in whole genome data. kSNP v2 has numerous improvements over kSNP v1 including SNP gene annotation; better scaling for draft genomes available as assembled contigs or raw, unassembled reads; a tool to identify the optimal value of k; distribution of packages of executables for Linux and Mac OS X for ease of installation and user-friendly use; and a detailed User Guide. SNP discovery is based on k-mer analysis, and requires no multiple sequence alignment or the selection of a single reference genome. Most target sets with hundreds of genomes complete in minutes to hours. SNP phylogenies are built by maximum likelihood, parsimony, and distance, based on all SNPs, only core SNPs, or SNPs present in some intermediate user-specified fraction of targets. The SNP-based trees that result are consistent with known taxonomy. kSNP v2 can handle many gigabases of sequence in a single run, and if one or more annotated genomes are included in the target set, SNPs are annotated with protein coding and other information (UTRs, etc.) from Genbank file(s). We demonstrate application of kSNP v2 on sets of viral and bacterial genomes, and discuss in detail analysis of a set of 68 finished E. coli and Shigella genomes and a set of the same genomes to which have been added 47 assemblies and four "raw read" genomes of H104:H4 strains from the recent European E. coli outbreak that resulted in both bloody diarrhea and hemolytic uremic syndrome (HUS), and caused at least 50 deaths.

  19. "You've Got to Teach People that Racism Is Wrong and Then They Won't Be Racist": Curricular Representations and Young People&'s Understandings of "Race" and Racism

    Science.gov (United States)

    Bryan, Audrey

    2012-01-01

    This paper critically examines the discursive (mis) representation of "race" and racism in the formal curriculum. Combining qualitative data derived from interviews with 35 young people who were enrolled in a Dublin-based, ethnically diverse secondary school, with a critical discursive analysis of 20 textbooks, the paper explores…

  20. Experimental Analysis of Linear Induction Motor under Variable Voltage Variable Frequency (VVVF Power Supply

    Directory of Open Access Journals (Sweden)

    Prasenjit D. Wakode

    2016-07-01

    Full Text Available This paper presents the complete analysis of Linear Induction Motor (LIM under VVVF. The complete variation of LIM air gap flux under ‘blocked Linor’ condition and starting force is analyzed and presented when LIM is given VVVF supply. The analysis of this data is important in further understanding of the equivalent circuit parameters of LIM and to study the magnetic circuit of LIM. The variation of these parameters is important to know the LIM response at different frequencies. The simulation and application of different control strategies such as vector control thus becomes quite easy to apply and understand motor’s response under such strategy of control.

  1. Afección de suelos agrícolas por metales pesados en áreas limítrofes a explotaciones mineras del Sureste de España

    Directory of Open Access Journals (Sweden)

    F. Belmonte Serrato

    2010-01-01

    Full Text Available Se analiza la contaminación por metales en suelos agrícolas en el entorno de la Sierra minera de Cartagena-La Unión. El muestreo se realizó cogiendo 20 muestras de suelo en uso agrícola mediante una distribución aleatoria en un área de unos 100 km2 en torno a la Sierra Minera. Los resultados han detectado concentraciones importantes, que alcanzan y superan los niveles máximos permitidos por diversas normativas internacionales de hasta 11 de los elementos denominados «metales pesados». Aluminio y Hierro destaca sobre los demás con concentraciones medias porcentuales de 13% y 10% respectivamente. Pero hay que destacar la contaminación excesiva de plomo (Pb y Zinc (Zn que duplica e incluso triplica el máximo establecido por las leyes más permisivas, superando con mucho los niveles máximos a partir de los cuales se requiere una intervención obligatoria en todas las legislaciones consultadas.

  2. Aportaciones corológicas para la cuenca del río Omecillo (Alava-Burgos y los territorios limítrofes alaveses de Valderejo y Sobrón, casi exclusivamente

    Directory of Open Access Journals (Sweden)

    BARREDO PEREZ, J.J.

    2001-01-01

    Full Text Available Se portan datos corológicos sobre noventa plantas, en Alava y Burgos, de las que ochenta y siete corresponden a la cuenca del Omecillo, Valderejo y Sobrón, siendo cincuenta y seis de ellas nuevas para esta comarca

  3. Aportaciones corológicas para la cuenca del río Omecillo (Alava-Burgos) y los territorios limítrofes alaveses de Valderejo y Sobrón, casi exclusivamente

    OpenAIRE

    BARREDO PEREZ, J.J.

    2001-01-01

    Se portan datos corológicos sobre noventa plantas, en Alava y Burgos, de las que ochenta y siete corresponden a la cuenca del Omecillo, Valderejo y Sobrón, siendo cincuenta y seis de ellas nuevas para esta comarca

  4. Percepciones sobre la degradación ambiental de agricultores orgánicos y convencionales en el ejido La Ciénega, municipio de El Limón, Jalisco, México

    OpenAIRE

    Rodolfo González-Figueroa; Peter R. W. Gerritsen; Therese K. Malischke

    2007-01-01

    La agricultura moderna en México está causando contaminación y erosión; de ello deriva la creciente pobreza y marginación que se padece en diversas zonas rurales, donde la cultura y el sustento dependen de la agricultura. Entender y responder al fenómeno de la degradación ambiental implica comprender las ideas, valores y esperanzas de los campesinos y, a partir de ello, construir alternativas. En este artículo se presentan cuatro estudios de caso en el...

  5. Drosophila Model for the Analysis of Genesis of LIM-kinase 1-Dependent Williams-Beuren Syndrome Cognitive Phenotypes: INDELs, Transposable Elements of the Tc1/Mariner Superfamily and MicroRNAs

    Czech Academy of Sciences Publication Activity Database

    Savvateeva-Popova, E.V.; Zhuravlev, A.V.; Brázda, Václav; Zakharov, G.A.; Kaminskaya, A.N.; Medvedeva, A.V.; Nikitina, E.; Tokmatcheva, E.V.; Dolgaya, J.F.; Kulikova, D.A.; Zatsepina, O.; Funikov, S.Y.; Ryazansky, S.S.; Evgen'ev, Michail B.

    2017-01-01

    Roč. 8 (2017), č. článku 123. ISSN 1664-8021 Institutional support: RVO:68081707 Keywords : b dna conformations * swiss-model * copy number * polytene chromosomes Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 3.789, year: 2016

  6. Pobreza estructural y migración limítrofe: aportes para pensar su articulación espacial en la Aglomeración Gran Buenos Aires

    Directory of Open Access Journals (Sweden)

    Mariana Marcos

    2010-12-01

    Full Text Available Las formas que adquiere la distribución espacial de los grupos en ámbitos urbanos constituyen una preocupación de larga data en las ciencias sociales. En esta línea, el nivel socioeconómico y la condición migratoria son variables frecuentemente utilizadas por los estudios interesados en entender cómo y porqué se produce una localización diferencial de los grupos sociales al interior del espacio urbano. El presente trabajo se propone analizar la distribución espacial de la población residente en la Aglomeración Gran Buenos Aires, explorando la articulación entre la diferenciación por nivel socioeconómico y condición migratoria. Se realiza un análisis estadístico-cartográfico por fracciones censales en base a datos del Censo de Población, Hogares y Viviendas 2001, buscando indagar en qué medida se intersectan la dimensión socioeconómica y la migratoria en los procesos de distribución y diferenciación espacial a nivel intraurbano.

  7. Determinación de propiedades físicas y parámetros de transporte a colas auríferas de mina El Limón

    Directory of Open Access Journals (Sweden)

    J. Ramírez

    2006-01-01

    Full Text Available Los parámetros de transporte de colas mineras y otras propiedades físicas, tales como permeabilidad intrínseca, distribución de tamaño de partículas, porosidad y densidad fueron determinados experimentalmente. Se realizaron experimentos de infiltración en columnas de laboratorio con el fin de determinar; la conductividad hidráulica, las propiedades capilares y estudiar el comportamiento hidrodinámico de las colas auríferas. También se hizo uso de un modelo matemático para simular la infiltración isotérmica unidimensional y ajustar los perfiles experimentales, con el propósito de determinar los parámetros de transporte que describen el proceso de infiltración. Aunque los experimentos se realizaron con diferentes grados de compactación, se obtuvieron parámetros con una coherencia razonable para describir la conductividad hidráulica y las propiedades capilares de las colas por este método. Estos parámetros fueron usados en un modelo simple para simular el lavado con agua del cianuro contenido en las colas auríferas.

  8. Desarrollo de Huerta Biointensiva en San Alberto de Siquirres, Limón, CR. Guía Básica de Campo para su implementación.

    OpenAIRE

    Chacón-Serrano, Katia; Solís-Rodríguez, Eugenio

    2011-01-01

    Proyecto de Graduación (Maestría en Gestión de Recursos Naturales y Tecnologías de Producción) Instituto Tecnológico de Costa Rica. Área Académica Agroforestal, 2011. La seguridad alimentaria de la humanidad cada vez se encuentra más amenazada por distintos factores, entre los principales se encuentra el aumento de la población, el mal manejo de los sistemas agrícolas y la degradación del ambiente (contaminación, pérdida de suelos y biodiversidad) (Núñez Solís 2010, Méndez Estrada & Monge ...

  9. Polyembryony and identification of Volkamerian lemon zygotic and nucellar seedlings using RAPD Poliembrionia e identificação de seedlings zigóticos e nucelares de limão volkameriano com RAPD

    Directory of Open Access Journals (Sweden)

    María Andrade-Rodríguez

    2004-06-01

    Full Text Available The objectives of this work were to evaluate the frequency of polyembryony, and to identify zygotic and nucellar seedlings of Citrus volkameriana using RAPD. Twenty-five polyembryonic and eight monoembryonic seeds were cultivated in vitrofor six months. DNA from seedlings was extracted and used in combination with five RAPD primers to identify zygotic or nucellar origin of the seedlings. Environmental conditions of the year affected significantly (POs objetivos deste trabalho foram avaliar a freqüência da poliembrionia e indentificar os seedlings zigóticos e nucelares de Citrus volkameriana usando RAPD. Cultivaram-se in vitro 25 sementes poliembriônicas e 8 monoembriônicas, por seis meses. Extraiu-se o DNA dos seedlings e usou-se em combinação com cinco primers RAPD para identificar a origem zigótica e nucelar das plântulas. Os resultados mostraram que as condições ambientais do ano afetaram significativamente (P<0,05 as características morfológicas dos frutos e o número de embriões por semente. Os índices de sementes poliembriônicas variaram nos três anos de avaliação (30,9%, 44,8% e 54,4%. As características morfológicas não se correlacionaram com a poliembrionia. A cultura in vitro possibilita que todos os embriões de cada semente cresçam, favorecendo os seedlings identificados como zigóticos. Nas sementes poliembriônicas e monoembriônicas, 25,9% e 87,5% dos seedlings, respectivamente, originaram-se sexualmente. Nem todos os seedlings zigóticos foram produzidos por embriões localizados no micrófilo das sementes poliembriônicas.

  10. Aberrant brain-stem morphometry associated with sleep disturbance in drug-naïve subjects with Alzheimer's disease

    Directory of Open Access Journals (Sweden)

    Lee JH

    2016-08-01

    Full Text Available Ji Han Lee,1 Won Sang Jung,2 Woo Hee Choi,3 Hyun Kook Lim4 1Washington University in St Louis, St Louis, MO, USA; 2Department of Radiology, 3Department of Nuclear Medicine, 4Department of Psychiatry, Saint Vincent Hospital, College of Medicine, The Catholic University of Korea, Suwon, South Korea Objective: Among patients with Alzheimer’s disease (AD, sleep disturbances are common and serious noncognitive symptoms. Previous studies of AD patients have identified deformations in the brain stem, which may play an important role in the regulation of sleep. The aim of this study was to further investigate the relationship between sleep disturbances and alterations in brain stem morphology in AD.Materials and methods: In 44 patients with AD and 40 healthy elderly controls, sleep disturbances were measured using the Neuropsychiatry Inventory sleep subscale. We employed magnetic resonance imaging-based automated segmentation tools to examine the relationship between sleep disturbances and changes in brain stem morphology.Results: Analyses of the data from AD subjects revealed significant correlations between the Neuropsychiatry Inventory sleep-subscale scores and structural alterations in the left posterior lateral region of the brain stem, as well as normalized brain stem volumes. In addition, significant group differences in posterior brain stem morphology were observed between the AD group and the control group.Conclusion: This study is the first to analyze an association between sleep disturbances and brain stem morphology in AD. In line with previous findings, this study lends support to the possibility that brain stem structural abnormalities might be important neurobiological mechanisms underlying sleep disturbances associated with AD. Further longitudinal research is needed to confirm these findings. Keywords: Alzheimer’s disease, sleep, brain stem, MRI, shape analysis

  11. Football business models: Why did Germany win the World Cup?

    DEFF Research Database (Denmark)

    Cortsen, Kenneth

    2016-01-01

    This article looks into the managerial aspects related to why and how Germany won the 2014 FIFA World Cup.......This article looks into the managerial aspects related to why and how Germany won the 2014 FIFA World Cup....

  12. Football business models: Why did Germany win the World Cup?

    DEFF Research Database (Denmark)

    Cortsen, Kenneth

    2014-01-01

    This article looks into the managerial aspects related to why and how Germany won the 2014 FIFA World Cup.......This article looks into the managerial aspects related to why and how Germany won the 2014 FIFA World Cup....

  13. Baobab Laboratory Information Management System: Development of an Open-Source Laboratory Information Management System for Biobanking.

    Science.gov (United States)

    Bendou, Hocine; Sizani, Lunga; Reid, Tim; Swanepoel, Carmen; Ademuyiwa, Toluwaleke; Merino-Martinez, Roxana; Meuller, Heimo; Abayomi, Akin; Christoffels, Alan

    2017-04-01

    A laboratory information management system (LIMS) is central to the informatics infrastructure that underlies biobanking activities. To date, a wide range of commercial and open-source LIMSs are available and the decision to opt for one LIMS over another is often influenced by the needs of the biobank clients and researchers, as well as available financial resources. The Baobab LIMS was developed by customizing the Bika LIMS software ( www.bikalims.org ) to meet the requirements of biobanking best practices. The need to implement biobank standard operation procedures as well as stimulate the use of standards for biobank data representation motivated the implementation of Baobab LIMS, an open-source LIMS for Biobanking. Baobab LIMS comprises modules for biospecimen kit assembly, shipping of biospecimen kits, storage management, analysis requests, reporting, and invoicing. The Baobab LIMS is based on the Plone web-content management framework. All the system requirements for Plone are applicable to Baobab LIMS, including the need for a server with at least 8 GB RAM and 120 GB hard disk space. Baobab LIMS is a server-client-based system, whereby the end user is able to access the system securely through the internet on a standard web browser, thereby eliminating the need for standalone installations on all machines.

  14. Dicty_cDB: Contig-U10675-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available 88 4e-17 JG0164( JG0164 )LIM protein, FHL4 - mouse 93 5e-17 AF053486_1( AF053486...NR12) RecName: Full=PDZ and LIM domain protein 7; AltName: Fu... 122 5e-26 (Q91XD2) RecName: Full=LIM and senescent cell anti...W4) RecName: Full=LIM and senescent cell antigen-like-conta... 119 5e-27 FN357330...id:none) Homo sapiens cDNA FLJ56117 complet... 120 7e-26 (Q7Z4I7) RecName: Full=LIM and senescent cell antig...2KJ33) RecName: Full=LIM and senescent cell antigen-like-conta... 119 1e-25 AK304760_1( AK304760 |pid:none)

  15. Low-index-metamaterial for gain enhancement of planar terahertz antenna

    Directory of Open Access Journals (Sweden)

    Qing-Le Zhang

    2014-03-01

    Full Text Available We theoretically present a high gain planar antenna at terahertz (THz frequencies by combing a conventional log-periodic antenna (LPA with a low-index-metamaterial (LIM, |n| < 1. The LIM is realized by properly designing a fishnet metamaterial using full-wave finite-element simulation. Owing to the impedance matching, the LIM can be placed seamlessly on the substrate of the LPA without noticeable reflection. The effectiveness of using LIM for antenna gain enhancement is confirmed by comparing the antenna performance with and without LIM, where significantly improved half-power beam-width (3-dB beam-width and more than 4 dB gain enhancement are seen within a certain frequency range. The presented LIM-enhanced planar THz antenna is compact, flat, low profile, and high gain, which has extensive applications in THz systems, including communications, radar, and spectroscopy.

  16. Model Driven Laboratory Information Management Systems

    Science.gov (United States)

    Li, Hao; Gennari, John H.; Brinkley, James F.

    2006-01-01

    Scientists in small research labs need more robust tools than spreadsheets to manage their data. However, no suitable laboratory information management systems (LIMS) are readily available; they are either too costly or too complex. We have therefore developed Seedpod, a model driven LIMS that allows users to create an integrated model of a LIMS without programming. Seedpod then automatically produces a relational database from the model, and dynamically generates a web-based graphical user interface. Our goal is to make LIMS easier to use by decreasing development time and cost, thereby allowing researchers to focus on producing and collecting data. PMID:17238388

  17. "They're thinking, well it's not as bad, I probably won't get addicted to that. But it's still got the nicotine in it, so…": Maturity, control and socialising: Negotiating identities in relation to smoking and vaping. A qualitative study of young adults in Scotland.

    Science.gov (United States)

    Lucherini, Mark; Rooke, Catriona; Amos, Amanda

    2017-11-04

    To explore the understandings of and engagement with e-cigarettes, of young adults from disadvantaged backgrounds, and how these may be impacting upon existing smoking identities. Twenty-two small group and 11 individual qualitative interviews conducted in Central Scotland with 72 16-24 year olds between September 2015 and April 2016. Participants were mostly smokers and ex-smokers from socio-economically disadvantaged backgrounds. While most participants had tried e-cigarettes, they generally held ambivalent views about e-cigarettes and vaping. Two overarching themes were identified which helped understand this. Firstly, e-cigarettes were understood by the participants in relation to their existing smoking identities. Vaping was viewed as less controllable and more addictive than smoking, which did not fit with their self-identity as controlled smokers. Secondly, they felt that vaping could not replace the social and cultural importance that smoking had in their lives. This study suggests that while young adults from disadvantaged areas are trying e-cigarettes for various reasons, vaping is rarely sustained. Through their own experiences of vaping and their observations of others vaping, the participants perceive the behaviour as endangering an existing acceptable and controlled smoking identity. Additionally, e-cigarettes were considered to be a jarring presence in existing social situations were smoking was valued. This study therefore provides insights into how young adults may be rationalising their continued smoking in the face of potentially less harmful alternatives. As new and novel nicotine delivery devices, and due to their similarity to smoking, e-cigarettes have the potential to help smokers in their quit attempts. However, the findings from this study raise questions about whether e-cigarettes are regarded as having this potential by young adult smokers from disadvantaged socio-economic environments where smoking is more commonplace and acceptable.

  18. Quem ganhou as eleições?: a validação dos resultados antes da criação da justiça eleitoral Who won the election?: the validation of the results before the creation of the electoral court

    Directory of Open Access Journals (Sweden)

    Paolo Ricci

    2013-03-01

    Full Text Available O presente artigo revisita a Primeira República brasileira (1894-1930 para elucidar a dinâmica político-partidária do contencioso eleitoral numa fase anterior à consagração da magistratura enquanto órgão proclamador da verdade das urnas, prerrogativa instituída somente com o Código de 1932. Recorremos à crítica dos protestos eleitorais e de suas refutações, quando existentes, apresentados por adversários políticos frente aos resultados dos escrutínios para a Câmara Federal - fontes ainda inéditas, disponíveis nos Diários e Anais da própria Casa legislativa. Os dados levantados mostram que, ao contrário da visão disseminada pela literatura, a degola das oposições não era usual, mas restrita a anos críticos, quando o situacionismo local não conseguia coordenar as disputas regionais pelo poder. Na maioria dos casos, o parlamento, que arbitrava sobre o reconhecimento dos seus diplomados, tendia a ratificar as escolhas adotadas ao nível subnacional. Desta forma, o caso brasileiro alerta para o fato de não se poder ler a adoção de tribunais independentes como mera resposta à solução do contencioso político que ocorria no parlamento, bem limitado. Tal achado nos permite pensar, antes, o advento da Justiça Eleitoral dentro de um projeto de reforma política mais ampla, incluindo a defesa de mecanismos democráticos para as eleições e que antecedem a validação dos votos.This article revisits the process of certification of election results by the National Congress during the Brazilian First Republic (1894-1930 before the Electoral Code of 1932 was created. We analyzed data on electoral protests and counter-protests submitted by political opponents to challenge electoral results of the Chamber of Deputies - unpublished sources available in Diaries and Annals of Deputies itself. Contrary to the widespread view in the literature we show that the practice kown as 'degola' ('beheading' whereby electoral results were altered by Congress, was not usual, but restricted to critical years, during moment of political uncertainty at state level. In most cases the Chamber of Deputies ratified the decision taken at the subnational level. Thus, the Brazilian case alert us to the fact that the adoption of independent courts is not just a mere response of how to solve electoral disputes that occurred in the parliament during the certification process. This finding allows us to think about the introduction of Electoral Justice as part of a broader project of political reform, including resolution mechanisms for the administration of elections.

  19. Sleep and cognitive problems in patients with attention-deficit hyperactivity disorder

    Directory of Open Access Journals (Sweden)

    Lee HK

    2014-09-01

    Full Text Available Hae Kook Lee, Jong-Hyun Jeong, Na-Young Kim, Min-hyeon Park, Tae-Won Kim, Ho-Jun Seo, Hyun-Kook Lim, Seung-Chul Hong, Jin-Hee Han Department of Psychiatry, College of Medicine, The Catholic University of Korea, Seoul, Korea Objectives: Attention-deficit hyperactivity disorder (ADHD is characterized by inattentive and impulsive behavior. Many ADHD patients reportedly have cognitive dysfunction and sleep problems, including longer sleep latency, lower sleep efficiency, and shorter total sleep time. The purpose of this study was to examine neurocognitive functions and nocturnal sleep parameters in patients with ADHD, using a cognitive function test and actigraphy.Methods: Subjects included 37 male patients with ADHD and 32 controls (7–12 years of age. For each participant, we determined intelligence quotient (IQ and administered the Matching Familiar Figures Test (MFFT and 72-hour actigraphy. The relationships between sleep parameters and cognitive functions were assessed.Results: ADHD patients significantly differed from controls in several cognitive functions and sleep variables. In the MFFT, response error rate (P<0.001 and error counts (P=0.003 were significantly increased in ADHD patients compared with control children. MFFT response latency was significantly shorter in ADHD patients than in controls (P<0.001. In addition, sleep latency (P=0.01, wake after sleep onset (WASO (P<0.001, and fragmentation index (P<0.001 were evaluated by actigraphy and found to be significantly increased in patients with ADHD compared with controls. However, no significant differences in total sleep time or sleep efficiency were observed. WASO and response error rates were positively correlated in patients with ADHD (rho =0.52, P=0.012. Furthermore, fragmentation index sleep variables were significantly positively correlated with response error (rho =0.44, P=0.008 and response latency rates (rho =0.4, P=0.018 in the MFFT. Reaction error rate was significantly

  20. Exposure–outcome analysis in depressed patients treated with paroxetine using population pharmacokinetics

    Directory of Open Access Journals (Sweden)

    Kim JR

    2015-09-01

    Full Text Available Jung-Ryul Kim,1 Hye In Woo,2 Mi-Ryung Chun,3 Shinn-Won Lim,4 Hae Deun Kim,5 Han Sung Na,5 Myeon Woo Chung,5 Woojae Myung,6 Soo-Youn Lee,1,3 Doh Kwan Kim6 1Department of Clinical Pharmacology and Therapeutics, Samsung Medical Center, Seoul, 2Department of Laboratory Medicine, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, 3Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, 4Samsung Advanced Institute for Health Sciences and Technology (SAIHST, Sungkyunkwan University, Seoul, 5Clinical Research Division, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety, Osong, Chungcheongbuk-do, 6Department of Psychiatry, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea Purpose: This study investigated population pharmacokinetics of paroxetine, and then performed an integrated analysis of exposure and clinical outcome using population pharmacokinetic parameter estimates in depressed patients treated with paroxetine. Patients and methods: A total of 271 therapeutic drug monitoring (TDM data were retrospectively collected from 127 psychiatric outpatients. A population nonlinear mixed-effects modeling approach was used to describe serum concentrations of paroxetine. For 83 patients with major depressive disorder, the treatment response rate and the incidence of adverse drug reaction (ADR were characterized by logistic regression using daily dose or area under the concentration–time curve (AUC estimated from the final model as a potential exposure predictor. Results: One compartment model was developed. The apparent clearance of paroxetine was affected by age as well as daily dose administered at steady-state. Overall treatment response rate was 72%, and the incidence of ADR was 30%. The logistic regression showed that exposure

  1. Latvijas reprezentācija sociālā portāla Facebook lapā "If you like Latvia, Latvia likes you" no 2014. gada janvāra līdz 2017. gada aprīlim

    OpenAIRE

    Ruskule, Laura

    2017-01-01

    Bakalaura darba „Latvijas reprezentācija sociālā portāla Facebook lapā „If you like Latvia Latvia likes you” no 2014. gada janvāra līdz 2017. gada aprīlim” mērķis ir sistematizēt un analizēt iegūtos datus par Latviju Facebook lapā „If you like Latvia Latvia likes you”. Bakalaura darba teorētiskajā daļā apskatīts „reprezentācijas” jēdziens. Skaidroti jēdzieni zīmols un valsts reprezentācija. Izveidota nodaļa par sociālajiem tīkliem. Skaidroti arī virtuālo identitāšu veidi un cēloņi. Pētījum...

  2. Influência da luz e da temperatura sobre a oxidação do óleo essencial de capim-limão (Cymbopogon citratus (D.C. Stapf Influence of light and temperature on the oxidation of the essential oil of lemongrass (Cymbopogon Citratus (D.C. Stapf

    Directory of Open Access Journals (Sweden)

    Luiz Gustavo de L. Guimarães

    2008-01-01

    Full Text Available The identification of the chemical compounds of the essential oil was performed with a gas chromatograph coupled to a mass spectrometer. The oil was left in the presence and absence of light and submitted to different temperatures to evaluate its stability. The yields of the major compounds were evaluated every fifteen days. Citral and myrcene, the major compounds of the essential oil, were degraded over time in both the presence and absence of light, but temperature only influenced the degradation of myrcene.

  3. Efecto de tres abonos orgánicos: lombricomposta, bocashi y tierra de corral en un cultivo intercalado de jitomate (Solanum lycopersicon) y pepino (Cucumis sativus) bajo invernadero en el ejido El Limón, Tepalcingo, Morelos, México

    OpenAIRE

    Hernández Tapia, Alejandro; Ramírez-Rivero,Libia Aidé; Corlay-Chee, Langen; Cruz Rodríguez, Juan Antonio

    2015-01-01

    Se evaluó una intercalación de jitomate y pepino bajo condiciones de invernadero, con un diseño de bloques completos al azar, con nueve tratamientos de abono en cuatro repeticiones (Bocashi, lombricomposta y tierra de corral con tres niveles de dosificación 0.5, 1.0 y 1.5 kg/m2).Se evaluó rendimiento y,en el caso del jitomate número de frutos dañados. Se empleó un análisis de varianza (ANOVA) y pruebas de comparación de medias (Tukey α=.05). En el caso del pepino, con el tratamiento lombri...

  4. Tokat’ın 17. Yüzyıl Âlim Şairlerinden İshak Bin Hasan Tokatî ve Nazmu’l-Ulum Adlı Mesnevîsi Poetry in Rhymed Couplets of Tokatlı İshâk Efendi Nazmu'l-Ulûm

    Directory of Open Access Journals (Sweden)

    Bayram ÖZFIRAT

    2013-03-01

    Full Text Available As manuscript works, which constitute some indispensabletreasure with respect to history of our literature, come back into light,our knowledge on religious literary genres, as well as other, no doubtincreases. Such works added to literature thanks to efforts byresearchers give us the opportunity of close acquaintance with religiousworks that are considered as the most significant and the most prolificproducts of Divan Poetry, and of more accurate interpretationsregarding the genre of such works. Apart from works such as aqâid, fiqhand catechism (ilm-i hal in verse, siyer (life of Muhammad in verse,exegeses (tafsir and hadithes in verse that are generally written inpoetic structure for these disciplines, there are also some poetic piecesabout a subdivision or important question of abovementioned Islamicsciences. Faraiz, Hegira of Muhammad, miraj-name, rules of hajj,miracles of Prophet, all in verse, can be mentioned among suchexamples. In the wake of our researches, we found out that thesecatechisms in verse constitute a notable part of our religious literature.Tokatlı İshâk Efendi was an important poet and writer who lived in 17th century. Biographic sources dores not mention him alot. The poetryin rhymed couplets, Nazmu’l-Ulûm, which we are working on shows ushow important poet he is. At his Nazmu’l-Ulûm İshâk Efendi givesinformation about different sciences and wants them to learn. Becauseof these properties Nazmu’l-Ulûm is a written verse advice. Nazmu’l-Ulûm have got strong rhymes. That is possible to say poetry in rhymedcouplets have fascinating expressions rather than bare tellings. Somany telling arts and describtions were given place in that book. Tokatlı İshâk Efendi on yedinci yüzyılda yaşamış önemli bir şâir ve yazardır. Biyografik kaynaklar kendisinden fazla bahsetmez. Ama eserlerinden yola çıktığımızda Tokatlı İshâk Efendi’nin yetenekli bir şâir olduğunu rahatlıkla söyleyebiliriz. İncelediğimiz Nazmu’l-Ulûm adlı mesnevîsinde şâir, çeşitli ilimler hakkında bilgi verdikten sonra bunların öğrenilmesi gerektiğini vurgulamıştır. Mesnevî, arûz vezninin “Mefāīlün Mefāīlün Faūlün” kalıbıyla yazılmış olup 1098/1687 yılında Tokat’ta telif edilmiştir. Mesnevî toplam 422 beyittir. Araştırmalarımız neticesinde yirmi iki nüshasını tespit ettiğimiz mesnevîde çeşitli ilimler hakkında bilgi verildikten sonra bunların öğrenilmesi gereği vurgulanmaktadır. Nazmu’l-Ulûm bu yönüyle manzûm bir nasihatnâme olup öğrenilmesinin öğütlendiği ilimlerin bazıları şunlardır: 1. İlm-i tecvîd, 2. İlm-i Kelâm, 3. İlm-i Fıkıh, 4. İlm-i Tasavvuf ve Ahlâk, 5. İlm-i Hadîs, 6. İlm-i Tefsîr, 7. İlm-i Tıp, 8. İlm-i Lugat, 9. İlm-i Nahv ve Sarf, 10. İlm-i Mantık, 11. İlm-i Edeb, 12. İlm-i Usûl-i Fıkıh, 13. İlm-i Meânî, 14. İlm-i Hisâb, 15. İlm-i Hendese, 17. İlm-i Kîmyâ, 18. İlm-i Arûz, 19. İlm-i Eş’âr. Nazmu’l-Ulûm kafiye yönünden oldukça sağlamdır. Hatta eserin kafiye bakımından kusursuz bir yapıya sahip olduğunu söylemek de mümkündür. Mesnevîyi oluşturan kelimler dikkate alındığında Arapça ve Farsça kelimelerin çokluğu dikkat çekmektedir. Ama eserin bu özelliği onun akıcılığından bir şey kaybettirmemiştir. Mesnevîde her türlü kafiyeye rastlanmakla birlikte; en çok zengin ve tam kafiyelere yer verilmiş, az sayıda yarım kafiye kullanılmıştır. Mesnevîde, bolca söz sanatlarına ve tasvirlere yer verilmiştir. Gereksiz ifadelerden kaçınılmaya çalışılmıştır. İshâk Efendi arûz veznine ve dile hâkim bir şâirdir. Nazmu’l-Ulûm’da şâirin vezin kusuruna düşmeden dili rahatlıkla kullanması dikkat çekicidir. Bu özellik İshâk Efendi’nin şâirlik gücüne, çok sayıda şiir yazmasına ve yaşadığı dönem olan on yedinci yüzyıla değin Türkçe anlatımdaki gelişmeye de bağlıdır.

  5. NCBI nr-aa BLAST: CBRC-PHAM-01-1520 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-PHAM-01-1520 ref|XP_001508080.1| PREDICTED: similar to amino acid feature: LIM...1, bp 331 .. 483; amino acid feature: LIM2, bp 517 .. 669; amino acid feature: homeodomain, bp 820 .. 999 [Ornithorhynchus anatinus] XP_001508080.1 7e-13 30% ...

  6. NCBI nr-aa BLAST: CBRC-LAFR-01-0893 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-LAFR-01-0893 ref|XP_001508080.1| PREDICTED: similar to amino acid feature: LIM...1, bp 331 .. 483; amino acid feature: LIM2, bp 517 .. 669; amino acid feature: homeodomain, bp 820 .. 999 [Ornithorhynchus anatinus] XP_001508080.1 1.2 29% ...

  7. NCBI nr-aa BLAST: CBRC-LAFR-01-0229 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-LAFR-01-0229 ref|XP_001508080.1| PREDICTED: similar to amino acid feature: LIM...1, bp 331 .. 483; amino acid feature: LIM2, bp 517 .. 669; amino acid feature: homeodomain, bp 820 .. 999 [Ornithorhynchus anatinus] XP_001508080.1 2.4 29% ...

  8. NCBI nr-aa BLAST: CBRC-OLAT-26-0094 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-OLAT-26-0094 ref|XP_001508080.1| PREDICTED: similar to amino acid feature: LIM...1, bp 331 .. 483; amino acid feature: LIM2, bp 517 .. 669; amino acid feature: homeodomain, bp 820 .. 999 [Ornithorhynchus anatinus] XP_001508080.1 3e-04 28% ...

  9. NCBI nr-aa BLAST: CBRC-LAFR-01-0404 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-LAFR-01-0404 ref|XP_001508080.1| PREDICTED: similar to amino acid feature: LIM...1, bp 331 .. 483; amino acid feature: LIM2, bp 517 .. 669; amino acid feature: homeodomain, bp 820 .. 999 [Ornithorhynchus anatinus] XP_001508080.1 1.4 27% ...

  10. NCBI nr-aa BLAST: CBRC-LAFR-01-0486 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-LAFR-01-0486 ref|XP_001508080.1| PREDICTED: similar to amino acid feature: LIM...1, bp 331 .. 483; amino acid feature: LIM2, bp 517 .. 669; amino acid feature: homeodomain, bp 820 .. 999 [Ornithorhynchus anatinus] XP_001508080.1 0.78 29% ...

  11. NCBI nr-aa BLAST: CBRC-LAFR-01-1572 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-LAFR-01-1572 ref|XP_001508080.1| PREDICTED: similar to amino acid feature: LIM...1, bp 331 .. 483; amino acid feature: LIM2, bp 517 .. 669; amino acid feature: homeodomain, bp 820 .. 999 [Ornithorhynchus anatinus] XP_001508080.1 1.2 34% ...

  12. NCBI nr-aa BLAST: CBRC-LAFR-01-0179 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-LAFR-01-0179 ref|XP_001508080.1| PREDICTED: similar to amino acid feature: LIM...1, bp 331 .. 483; amino acid feature: LIM2, bp 517 .. 669; amino acid feature: homeodomain, bp 820 .. 999 [Ornithorhynchus anatinus] XP_001508080.1 0.41 31% ...

  13. NCBI nr-aa BLAST: CBRC-OCUN-01-1479 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-OCUN-01-1479 ref|XP_001508080.1| PREDICTED: similar to amino acid feature: LIM...1, bp 331 .. 483; amino acid feature: LIM2, bp 517 .. 669; amino acid feature: homeodomain, bp 820 .. 999 [Ornithorhynchus anatinus] XP_001508080.1 1e-17 30% ...

  14. NCBI nr-aa BLAST: CBRC-HSAP-01-0174 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-HSAP-01-0174 ref|XP_001508080.1| PREDICTED: similar to amino acid feature: LIM...1, bp 331 .. 483; amino acid feature: LIM2, bp 517 .. 669; amino acid feature: homeodomain, bp 820 .. 999 [Ornithorhynchus anatinus] XP_001508080.1 1e-05 30% ...

  15. NCBI nr-aa BLAST: CBRC-TTRU-01-1157 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-TTRU-01-1157 ref|XP_001508080.1| PREDICTED: similar to amino acid feature: LIM...1, bp 331 .. 483; amino acid feature: LIM2, bp 517 .. 669; amino acid feature: homeodomain, bp 820 .. 999 [Ornithorhynchus anatinus] XP_001508080.1 6e-10 34% ...

  16. NCBI nr-aa BLAST: CBRC-LAFR-01-2065 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-LAFR-01-2065 ref|XP_001508080.1| PREDICTED: similar to amino acid feature: LIM...1, bp 331 .. 483; amino acid feature: LIM2, bp 517 .. 669; amino acid feature: homeodomain, bp 820 .. 999 [Ornithorhynchus anatinus] XP_001508080.1 1.3 31% ...

  17. NCBI nr-aa BLAST: CBRC-LAFR-01-0290 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-LAFR-01-0290 ref|XP_001508080.1| PREDICTED: similar to amino acid feature: LIM...1, bp 331 .. 483; amino acid feature: LIM2, bp 517 .. 669; amino acid feature: homeodomain, bp 820 .. 999 [Ornithorhynchus anatinus] XP_001508080.1 4.6 29% ...

  18. NCBI nr-aa BLAST: CBRC-LAFR-01-0041 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-LAFR-01-0041 ref|XP_001508080.1| PREDICTED: similar to amino acid feature: LIM...1, bp 331 .. 483; amino acid feature: LIM2, bp 517 .. 669; amino acid feature: homeodomain, bp 820 .. 999 [Ornithorhynchus anatinus] XP_001508080.1 0.39 31% ...

  19. NCBI nr-aa BLAST: CBRC-HSAP-17-0026 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-HSAP-17-0026 ref|XP_001508080.1| PREDICTED: similar to amino acid feature: LIM...1, bp 331 .. 483; amino acid feature: LIM2, bp 517 .. 669; amino acid feature: homeodomain, bp 820 .. 999 [Ornithorhynchus anatinus] XP_001508080.1 6e-08 27% ...

  20. NCBI nr-aa BLAST: CBRC-LAFR-01-0849 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-LAFR-01-0849 ref|XP_001508080.1| PREDICTED: similar to amino acid feature: LIM...1, bp 331 .. 483; amino acid feature: LIM2, bp 517 .. 669; amino acid feature: homeodomain, bp 820 .. 999 [Ornithorhynchus anatinus] XP_001508080.1 0.018 29% ...

  1. NCBI nr-aa BLAST: CBRC-LAFR-01-1340 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-LAFR-01-1340 ref|XP_001508080.1| PREDICTED: similar to amino acid feature: LIM...1, bp 331 .. 483; amino acid feature: LIM2, bp 517 .. 669; amino acid feature: homeodomain, bp 820 .. 999 [Ornithorhynchus anatinus] XP_001508080.1 0.43 29% ...

  2. NCBI nr-aa BLAST: CBRC-LAFR-01-0497 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-LAFR-01-0497 ref|XP_001508080.1| PREDICTED: similar to amino acid feature: LIM...1, bp 331 .. 483; amino acid feature: LIM2, bp 517 .. 669; amino acid feature: homeodomain, bp 820 .. 999 [Ornithorhynchus anatinus] XP_001508080.1 0.088 32% ...

  3. NCBI nr-aa BLAST: CBRC-LAFR-01-0158 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-LAFR-01-0158 ref|XP_001508080.1| PREDICTED: similar to amino acid feature: LIM...1, bp 331 .. 483; amino acid feature: LIM2, bp 517 .. 669; amino acid feature: homeodomain, bp 820 .. 999 [Ornithorhynchus anatinus] XP_001508080.1 2.0 28% ...

  4. NCBI nr-aa BLAST: CBRC-PHAM-01-1587 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-PHAM-01-1587 ref|XP_001508080.1| PREDICTED: similar to amino acid feature: LIM...1, bp 331 .. 483; amino acid feature: LIM2, bp 517 .. 669; amino acid feature: homeodomain, bp 820 .. 999 [Ornithorhynchus anatinus] XP_001508080.1 2e-09 28% ...

  5. Type of respiratory symptom

    African Journals Online (AJOL)

    acer

    Lim et al., 2012; Rehfuess et al., 2009; Smith, 2000). Although outdoor air pollution is an important and growing concern in sub-. Saharan Africa, it has been estimated that household air pollution (HAP) is actually a more significant environmental health threat. (Lim et al., 2012). World-wide, exposure to high levels of HAP is ...

  6. Discriminant Validity of the WISC-IV Culture-Language Interpretive Matrix

    Science.gov (United States)

    Styck, Kara M.; Watkins, Marley W.

    2014-01-01

    The Culture-Language Interpretive Matrix (C-LIM) was developed to help practitioners determine the validity of test scores obtained from students who are culturally and linguistically different from the normative group of a test. The present study used an idiographic approach to investigate the diagnostic utility of the C-LIM for the Wechsler…

  7. Sadhana | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Sadhana. Lim Jing Yi. Articles written in Sadhana. Volume 35 Issue 1 February 2010 pp 87-95. Preparation and characterization of plasticized high molecular weight PVC-based polymer electrolytes · S Ramesh Geok Bee Teh Rong-Fuh Louh Yong Kong Hou Pung Yen Sin Lim Jing Yi · More Details ...

  8. Structure Characterization and Lead Detoxification Effect of Carboxymethylated Melanin Derived from Lachnum Sp.

    Science.gov (United States)

    Zong, Shuai; Li, Lan; Li, Jinglei; Shaikh, Farnaz; Yang, Liu; Ye, Ming

    2017-06-01

    In the present study, an intracellular melanin, named LIM205, was separated from Lachnum YM205 mycelia and was purified on a Sephadex G-15 column. The molecular weight of LIM205 was determined as 522 Da, and its molecular formula was speculated as C 28 H 14 N 2 O 7 S. The possible chemical structure of LIM205 was determined according to the results of Fourier transform infrared (FT-IR), 1 H NMR, 13 C NMR, and pyrolysis/GC-MS analysis. With the aim to increase its water solubility, its carboxymethylated derivative, named CLIM205, was formed by the substitution of hydrogen atoms in LIM205 with one, two, and three carboxymethylate groups. FT-IR, UV, and ESI-MS analysis demonstrated that the carboxymethylate groups were conjugated onto LIM205. The lead detoxification activities of LIM205 and CLIM205 had also been investigated. In vivo test showed that both LIM205 and CLIM205 reduced the tissue lead concentration, enhanced lead excretion, and reversed lead-induced alterations in superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and malondialdehyde (MDA) concentrations in mice, with CLIM205 showed better efficacy. The study indicates that LIM205 and CLIM205 have significant lead detoxification effect which will contribute to solve related problems.

  9. Seasonal and decadal forecasts of Atlantic Sea surface temperatures using a linear inverse model

    Science.gov (United States)

    Huddart, Benjamin; Subramanian, Aneesh; Zanna, Laure; Palmer, Tim

    2017-09-01

    Predictability of Atlantic Ocean sea surface temperatures (SST) on seasonal and decadal timescales is investigated using a suite of statistical linear inverse models (LIM). Observed monthly SST anomalies in the Atlantic sector (between 22°S and 66°N) are used to construct the LIMs for seasonal and decadal prediction. The forecast skills of the LIMs are then compared to that from two current operational forecast systems. Results indicate that the LIM has good forecast skill for time periods of 3-4 months on the seasonal timescale with enhanced predictability in the spring season. On decadal timescales, the impact of inter-annual and intra-annual variability on the predictability is also investigated. The results show that the suite of LIMs have forecast skill for about 3-4 years over most of the domain when we use only the decadal variability for the construction of the LIM. Including higher frequency variability helps improve the forecast skill and maintains the correlation of LIM predictions with the observed SST anomalies for longer periods. These results indicate the importance of temporal scale interactions in improving predictability on decadal timescales. Hence, LIMs can not only be used as benchmarks for estimates of statistical skill but also to isolate contributions to the forecast skills from different timescales, spatial scales or even model components.

  10. The Business of Politics Commerce, and Culture in East Asia

    DEFF Research Database (Denmark)

    Ooi, Can-Seng

    2016-01-01

    Review of: "Cultural Policies in East Asia: Dynamics Between the State, Arts and Creative Industries". Edited by Hye-Kyung Lee and Lorraine Lim. Basingstoke: Palgrave, Macmillan, 2014. 229 pp.......Review of: "Cultural Policies in East Asia: Dynamics Between the State, Arts and Creative Industries". Edited by Hye-Kyung Lee and Lorraine Lim. Basingstoke: Palgrave, Macmillan, 2014. 229 pp....

  11. Untitled

    Indian Academy of Sciences (India)

    dependent method. Let a be a 2-cluster decomposition and E°, u"(x") be a negative eigenvalue and the associated eigenfunction of H*. Let Wi and W: be the wave operators defined by. W; =s– lim ethe-tº, (7.1) t – H. Co. W; = s— lim ethe-"-J, (7.2).

  12. A Positive Approach to Change: The Role of Appreciative Inquiry in Library and Information Organisations

    Science.gov (United States)

    Kelly, Tricia

    2010-01-01

    Library and information management (LIM) organisations are on an almost continual path of change driven by changes in technology, service models, staffing structures, and financial allocations. The way in which LIM organisations approach change varies, as does the success rate of change management procedures undertaken. One particular approach to…

  13. Resonance – Journal of Science Education | Indian Academy of ...

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education. Sálim Ali. Articles written in Resonance – Journal of Science Education. Volume 2 Issue 1 January 1997 pp 81-94 Reflections. An Ornithological Pilgrimage to Lake Manasarowar and Mount Kailas · Sálim Ali · More Details Fulltext PDF ...

  14. The National Interests of Singapore: A Background Study for United States Policy

    Science.gov (United States)

    1993-12-01

    number of leftists, including thle PAP’s Lim Chin Siong,. This unfortunate line painted Lim Yew Hock with the British lackey brush aiid doomed his...enemies, ruthless.v and completelv. It i,- an instrument of controlled fury. Soldiersr must have -, teet In their ,ouls... must learn to kill and not

  15. Portraits of life: Patterns of events over the lifespan

    NARCIS (Netherlands)

    Schroots, J.J.F.; Assink, M.H.J.

    2005-01-01

    This explorative content-analytic study completes earlier studies on the lifespan distributions of number and affect of past and future life-events, collected by means of the Life-line Interview Method (LIM), for three age groups of men and women (young, middle and late adulthood). LIM events were

  16. Satellite observation and mapping of wintertime ozone variability in the lower stratosphere

    Science.gov (United States)

    Geller, Marvin A.; Chi, Yuechen; Rood, Richard B.; Douglass, Anne R.; Kaye, Jack A.; Allen, Dale J.

    1992-01-01

    Comparison is made between 30 mbar ozone fields that are generated by a transport chemistry model utilizing the winds from the Goddard Space Flight Center stratospheric data assimilation system (STRATAN), observations from the LIMS instrument on Nimbus-7, and the ozone fields that result from 'flying a mathematical simulation of LIMS observations through the transport chemistry model ozone fields. The modeled ozone fields were found to resemble the LIMS observations, but the model fields show much more temporal and spatial structure than do the LIMS observations. The 'satellite mapped' model results resemble the LIMS observations much more closely. These results are very consistent with the earlier discussions of satellite space-time sampling by Salby.

  17. Are we near the predictability limit of tropical Indo-Pacific sea surface temperatures?

    Science.gov (United States)

    Newman, Matthew; Sardeshmukh, Prashant D.

    2017-08-01

    The predictability of seasonal anomalies worldwide rests largely on the predictability of tropical sea surface temperature (SST) anomalies. Tropical forecast skill is also a key metric of climate models. We find, however, that despite extensive model development, the tropical SST forecast skill of the operational North American Multi-Model Ensemble (NMME) of eight coupled atmosphere-ocean models remains close both regionally and temporally to that of a vastly simpler linear inverse model (LIM) derived from observed covariances of SST, sea surface height, and wind fields. The LIM clearly captures the essence of the predictable SST dynamics. The NMME and LIM skills also closely track and are only slightly lower than the potential skill estimated using the LIM's forecast signal-to-noise ratios. This suggests that the scope for further skill improvement is small in most regions, except in the western equatorial Pacific where the NMME skill is currently much lower than the LIM skill.

  18. Kenya | Page 63 | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Five years after retooling its first recycled computers and finding them a good home, Computers for Schools Kenya (CFSK) has won a coveted Africa-wide prize for its work. CFSK won the 2007 African ICT Achievers Award in the category of top civil society organization helping to bridge the digital divide on the continent.

  19. Sanctuary … and Other Notes from the "NEJHE" Beat …

    Science.gov (United States)

    Harney, John O.

    2016-01-01

    How will higher education fare under a President Donald Trump? According to this author, the campaign's misogyny shouldn't sit well with a student body that is now majority female, its disavowal of climate changes won't impress research universities, and the xenophobia won't help economies and cultures bolstered by foreign enrollment. The number…

  20. Kenya | Page 63 | IDRC - International Development Research Centre

    International Development Research Centre (IDRC) Digital Library (Canada)

    Five years after retooling its first recycled computers and finding them a good home, Computers for Schools Kenya (CFSK) has won a coveted Africa-wide prize for its work. CFSK won the 2007 African ICT Achievers Award in the category of top civil society organization helping to bridge the digital divide on the continent.

  1. More than a golden hello.

    Science.gov (United States)

    Janstarkers

    2017-08-02

    Golden hellos for nurses are okay, but won't improve retention of staff. As soon as new recruits learn how short-staffed wards are and how few trained nurses are on shifts, they won't stay long anyway.

  2. Enhanced UXO Discrimination Using Frequency Domain Electromagnetic Induction

    Science.gov (United States)

    2010-05-01

    Geophex Ltd. I.J. Won, Alex Oren, Frank Funak, and Bill San Filipo were responsible for the development of the EMI sensor technology on which the GEMTADS...Induction,” ESTCP MM-0033 Final Report, submitted May, 2007. H. Nelson, D. Steinhurst, B. Barrow, T. Bell, N. Khadr, W. San Filipo , I. Won. 9. “Moving

  3. Publications | Page 273 | IDRC - International Development ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Five years after retooling its first recycled computers and finding them a good home, Computers for Schools Kenya (CFSK) has won a coveted Africa-wide prize for its work. CFSK won the 2007 African ICT Achievers Award in the category of... Partnering for accountability. It sounds simple. Setting accountability principles for ...

  4. Tanzania | Page 34 | IDRC - International Development Research ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Five years after retooling its first recycled computers and finding them a good home, Computers for Schools Kenya (CFSK) has won a coveted Africa-wide prize for its work. CFSK won the 2007 African ICT Achievers Award in the category of top civil society organization helping to bridge the digital divide on the continent.

  5. The Future of Urban Ecology

    DEFF Research Database (Denmark)

    Elle, Morten

    1998-01-01

    This article is discusing the basic conditions for a positive development of urban ecology in Denmark. A number of battles has to be won.......This article is discusing the basic conditions for a positive development of urban ecology in Denmark. A number of battles has to be won....

  6. Korean Waste Management Law, Presidential Decree Number 13480, and Prime Minister Order Number 397

    Science.gov (United States)

    1994-06-01

    stock or property: more than 300,000,000 won of captal stock in case of a corporation, more thart 600.000.000 won of estimated properties in case of...theWtrust- disp F meth•bed ir•-cy• W 1):t- eco ntheti aub t f sto raget Leather 40, Waste Paint & Lacquer 50, Other Waste Synthetic High Polymers 601

  7. Physiological characteristics of an aging Olympic athlete

    DEFF Research Database (Denmark)

    Nybo, Lars; Schmidt, Jakob Friis; Fritzdorf, Stephen

    2014-01-01

    To investigate the physiological basis of continued world-class performance of a world-class rower who won medals (3 gold and 2 bronze) at five consecutive Olympic Games.......To investigate the physiological basis of continued world-class performance of a world-class rower who won medals (3 gold and 2 bronze) at five consecutive Olympic Games....

  8. Mathematical Model and Computational Analysis of Selected Transient States of Cylindrical Linear Induction Motor Fed via Frequency Converter

    Directory of Open Access Journals (Sweden)

    Andrzej Rusek

    2008-01-01

    Full Text Available The mathematical model of cylindrical linear induction motor (C-LIM fed via frequency converter is presented in the paper. The model was developed in order to analyze numerically the transient states. Problems concerning dynamics of ac-machines especially linear induction motor are presented in [1 – 7]. Development of C-LIM mathematical model is based on circuit method and analogy to rotary induction motor. The analogy between both: (a stator and rotor windings of rotary induction motor and (b winding of primary part of C-LIM (inductor and closed current circuits in external secondary part of C-LIM (race is taken into consideration. The equations of C-LIM mathematical model are presented as matrix together with equations expressing each vector separately. A computational analysis of selected transient states of C-LIM fed via frequency converter is presented in the paper. Two typical examples of C-LIM operation are considered for the analysis: (a starting the motor at various static loads and various synchronous velocities and (b reverse of the motor at the same operation conditions. Results of simulation are presented as transient responses including transient electromagnetic force, transient linear velocity and transient phase current.

  9. Implementation and user satisfaction with forensic laboratory information systems in death investigation offices.

    Science.gov (United States)

    Levy, Bruce P

    2013-03-01

    The use of laboratory information management systems (LIMSs) in forensic pathology and death investigation systems has lagged behind the greater pathology community. Yet the logistical needs of a modern medical examiner or coroner office could be well served by a robust forensic LIMS, and the data stored in a forensic LIMS could be effectively mined for the protection of the public's health and safety.In spring 2007, the National Association of Medical Examiners conducted a survey of its members to determine the use of and satisfaction with forensic LIMS. This survey was repeated in the fall of 2011. The responses to the 2 surveys were compared to note any trends or changes to LIMS use by medical examiners and coroners.Although the use of LIMS has increased in the 4 1/2 years between surveys, 18% of death investigation systems still do not have a forensic LIMS. The percentage of offices with home-developed systems has increased, whereas the user's satisfaction with these systems has decreased. This may be due to limited budgets to either purchase or develop systems. The integration of images into these systems has increased, but not nearly to the level that should be present in an image-dependent field. Users of these systems are cognizant of the features that a forensic LIMS should have to ensure the smooth operation of a death investigation office.

  10. Page 1 r Almost periodic functions 3 evaluation functional at seS ...

    Indian Academy of Sciences (India)

    (b) h has an extension hec(S) and for all nets (t.) c T with t, -s for some seS the following double limits exist and are equal: lim lim h,(t.) = limlim h,(t.). rt 3. o: n. (c) For all nets (t,) c T with t. — s for some seS one has e, – e, quasiuniformly on {h, neN}. (d) For all sequences (t.) c Tsuch that lim, , , h,(t) = L., exists for ne N one has e ...

  11. Cómo desarrollar las inteligencias múltiples en el aula para mejorar el aprendizaje en las niñas del séptimo año de Educación Básica de la Escuela Albino del Curto de la parroquia General Plaza, cantón Limón Indanza, durante el año lectivo 2007-2008

    OpenAIRE

    Pucha Tambo, Carmita Cecilia

    2007-01-01

    La palabra "inteligencia" tiene su origen en la unión de dos vocablos latinos: Inter=entre, y eligere=escoger. En su sentido más amplio, significa la capacidad cerebral por la cual conseguimos penetrar en la comprensión de las cosas eligiendo el mejor camino. La formación de ideas, el juicio y el razonamiento son frecuentemente señalados como actos esenciales de la inteligencia, como "facultad de comprender". Analizando de modo sucinto las raíces biológicas de la inteligencia, se descubre ...

  12. Disease: H00656 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available McGrath MJ Four and a half LIM protein 1 gene mutations cause four distinct human myopathies: a comprehen...sive review of the clinical, histological and pathological features. Neuromuscul Di

  13. Notch-dependent epithelial fold determines boundary formation between developmental fields in the Drosophila antenna.

    Science.gov (United States)

    Ku, Hui-Yu; Sun, Y Henry

    2017-07-01

    Compartment boundary formation plays an important role in development by separating adjacent developmental fields. Drosophila imaginal discs have proven valuable for studying the mechanisms of boundary formation. We studied the boundary separating the proximal A1 segment and the distal segments, defined respectively by Lim1 and Dll expression in the eye-antenna disc. Sharp segregation of the Lim1 and Dll expression domains precedes activation of Notch at the Dll/Lim1 interface. By repressing bantam miRNA and elevating the actin regulator Enable, Notch signaling then induces actomyosin-dependent apical constriction and epithelial fold. Disruption of Notch signaling or the actomyosin network reduces apical constriction and epithelial fold, so that Dll and Lim1 cells become intermingled. Our results demonstrate a new mechanism of boundary formation by actomyosin-dependent tissue folding, which provides a physical barrier to prevent mixing of cells from adjacent developmental fields.

  14. Paxillin enables attachment-independent tyrosine phosphorylation of focal adhesion kinase and transformation by RAS

    National Research Council Canada - National Science Library

    Wade, Ramon; Brimer, Nicole; Lyons, Charles; Vande Pol, Scott

    2011-01-01

    ... expression of paxillin and was not supported by HIC5. The support of attachment-independent FAK tyrosine phosphorylation required the paxillin LIM domains and suggested that paxillin might facilitate oncogenic transformation...

  15. Disease: H00745 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available genetically undefined, suggesting genetic heterogeneity. HyperPP is characterized by attacks of flaccid lim...b paralysis or, rarely, weakness of the eye and throat muscles. Triggers for these attacks

  16. Untitled

    Indian Academy of Sciences (India)

    154. Hayes M. H. Lim JS, Oppenheim AV 1980a Signal reconstruction from phase or magnitude. IEEE Trans. Acoust. ... Merchant GA, Parks T W 1983 Reconstruction of signals from phase: Efficient algorithm, segmentations, and generalizations.

  17. Region 7 Laboratory Information Management System

    Data.gov (United States)

    U.S. Environmental Protection Agency — This is metadata documentation for the Region 7 Laboratory Information Management System (R7LIMS) which maintains records for the Regional Laboratory. Any Laboratory...

  18. Difusioontensoruuringud / Emily Singer

    Index Scriptorium Estoniae

    Singer, Emily

    2006-01-01

    Minnesota ülikooli meditsiiniteaduskonnas töötav neuroloog ja psühhiaater Kelvin Lim kasutab uudset peaaju skaneerimise meetodit skisofreenia uurimiseks. Artikkel üldpealkirja all: 10 tulevikutehnoloogiat

  19. Modeling Food Web Interactions in Benthic Deep-Sea Ecosystems: A Practical Guide

    National Research Council Canada - National Science Library

    KARLINE SOETAERT; DICK VAN OEVELEN

    2009-01-01

    .... Here, we show how to use so-called linear inverse models (LIMs) to reconstruct material and energy flows through food webs in which the number of measurements is a fraction of the total number of flows...

  20. Notch-dependent epithelial fold determines boundary formation between developmental fields in the Drosophila antenna.

    Directory of Open Access Journals (Sweden)

    Hui-Yu Ku

    2017-07-01

    Full Text Available Compartment boundary formation plays an important role in development by separating adjacent developmental fields. Drosophila imaginal discs have proven valuable for studying the mechanisms of boundary formation. We studied the boundary separating the proximal A1 segment and the distal segments, defined respectively by Lim1 and Dll expression in the eye-antenna disc. Sharp segregation of the Lim1 and Dll expression domains precedes activation of Notch at the Dll/Lim1 interface. By repressing bantam miRNA and elevating the actin regulator Enable, Notch signaling then induces actomyosin-dependent apical constriction and epithelial fold. Disruption of Notch signaling or the actomyosin network reduces apical constriction and epithelial fold, so that Dll and Lim1 cells become intermingled. Our results demonstrate a new mechanism of boundary formation by actomyosin-dependent tissue folding, which provides a physical barrier to prevent mixing of cells from adjacent developmental fields.

  1. Notch-dependent epithelial fold determines boundary formation between developmental fields in the Drosophila antenna

    Science.gov (United States)

    2017-01-01

    Compartment boundary formation plays an important role in development by separating adjacent developmental fields. Drosophila imaginal discs have proven valuable for studying the mechanisms of boundary formation. We studied the boundary separating the proximal A1 segment and the distal segments, defined respectively by Lim1 and Dll expression in the eye-antenna disc. Sharp segregation of the Lim1 and Dll expression domains precedes activation of Notch at the Dll/Lim1 interface. By repressing bantam miRNA and elevating the actin regulator Enable, Notch signaling then induces actomyosin-dependent apical constriction and epithelial fold. Disruption of Notch signaling or the actomyosin network reduces apical constriction and epithelial fold, so that Dll and Lim1 cells become intermingled. Our results demonstrate a new mechanism of boundary formation by actomyosin-dependent tissue folding, which provides a physical barrier to prevent mixing of cells from adjacent developmental fields. PMID:28708823

  2. PROPORSI BANGSA, UMUR, BOBOT BADAN AWAL DAN SKOR KONDISI TUBUH SAPI BAKALAN PADA USAHA PENGGEMUKAN

    Directory of Open Access Journals (Sweden)

    Frandz Rumbiak Pawere

    2013-03-01

    Full Text Available Penelitian ini bertujuan untuk mengetahui proporsi bangsa, umur, skor kondisi tubuh sapi bakalan yang digemukkan pada usaha penggemukan. Penelitian dilaksanakan di CV. Restu Bumi, Kabupaten Bantul selama 1 tahun yakni dari bulan Mei 2011 sampai bulan Mei 2012. Materi yang digunakan adalah 500 ekor sapi meliputi bangsa sapi Limmousin Peranakan Ongole (LimPO, Peranakan Ongole (PO dan Simmental Peranakan Ongole (SimPO. Parameter yang diamati adalah bangsa, umur, body condition score (BCS. Metode analisis yang digunakan adalah analisis deskriptif. Hasil penelitian menunjukkan bahwa proporsi bangsa sapi yang digemukkan-SimPO (56%, LimPO (19% dan PO (25%, umur sapi yang paling banyak digemukkan adalah poel 1 dan poel 2 masing-masing 36% dan 25%. Bobot badan awal sapi 300 kg didominasi oleh bangsa sapi silangan (SimPO dan LimPO. Nilai body condition score (BCS awal penggemukan 2-3. (Kata kunci: Bangsa, LimPO, PO, SimPO, Penggemukan

  3. Kolm eestikeelset sotsioloogiaõpikut / Henn Käärik

    Index Scriptorium Estoniae

    Käärik, Henn

    2002-01-01

    Rets. rmt. : Sotsioloogia / Beth B. Hess, Elizabeth W. Markson, Peter J. Stein. Tallinn : Külim, 2000. Aimre, Ivar. Sotsioloogia. Tallinn : Sisekaitseakadeemia, 2001. Graf, Eha-Mai ; Paul, Maarja. Üldsotsioloogia. Tallinn : Pirgu Arenduskeskus, 1997

  4. Anti-obesity effect of phenylcoumarins from two Calophyllum spp in ...

    African Journals Online (AJOL)

    Anti-obesity effect of phenylcoumarins from two Calophyllum spp in 3T3-L1 adipocytes. Siroshini Thiagarajan, Fui-Lu Yong, Hemaroopini Subramaniam, Vivien Yi- Mian Jong Jong, Chan-Kiang Lim, Yee-How Say ...

  5. Terapia conductual dialéctica

    National Research Council Canada - National Science Library

    Gempeler, Juanita

    2008-01-01

    ... dialéctica (TCD), desarrollada a finales de los años noventa por la psiquiatra Marsha Linehan, como respuesta a las dificultades en el tratamiento del trastorno de personalidad limítrofe (TPL). Se destaca...

  6. Eesti Linnade Liidu, Eesti Omavalitsusliitude Ühenduse, Eesti Korteriühistute Liidu ja Eesti Gaasiliidu pöördumine = Obrashtshenije k Sojuzu Gorodov Estonii, Obedineniju Samoupravlenii Estonii, Sojuzu Kvartirnõhh Tovarishtshestv Estonii i Sojuzu

    Index Scriptorium Estoniae

    2003-01-01

    Pöördumises tehakse valitsusele ettepanek kavandada kodugaasiseadmete väljavahetamise projekt koos finantseerimise kavaga. Pöördumisele on alla kirjutanud Jaanus Tamkivi, Toomas Välimäe, Marit Otsing ja Allan Sepp

  7. Models of Prime-Like Sequences Generated by Least Element Sieve Operations Like the Sieve of Eratosthenes

    OpenAIRE

    Baum, Leonard E.

    2017-01-01

    We suggest other models of sieve generated sequences like the Sieve of Eratosthenes to explain randomness properties of the prime numbers, like the twin prime conjecture, the lim sup conjecture, the Riemann conjecture, and the prime number theorem.

  8. Compact and Thermosensitive Nature-inspired Micropump

    Science.gov (United States)

    Kim, Hyejeong; Kim, Kiwoong; Lee, Sang Joon

    2016-10-01

    Liquid transportation without employing a bulky power source, often observed in nature, has been an essential prerequisite for smart applications of microfluidic devices. In this report, a leaf-inspired micropump (LIM) which is composed of thermo-responsive stomata-inspired membrane (SIM) and mesophyll-inspired agarose cryogel (MAC) is proposed. The LIM provides a durable flow rate of 30 μl/h · cm2 for more than 30 h at room temperature without external mechanical power source. By adapting a thermo-responsive polymer, the LIM can smartly adjust the delivery rate of a therapeutic liquid in response to temperature changes. In addition, as the LIM is compact, portable, and easily integrated into any liquid, it might be utilized as an essential component in advanced hand-held drug delivery devices.

  9. Hodgkin Lymphoma (For Kids)

    Science.gov (United States)

    ... Skating Living With Stepparents Be a Green Kid Hodgkin Lymphoma KidsHealth > For Kids > Hodgkin Lymphoma Print A A ... of the cool things he's missed. What Is Hodgkin Lymphoma? Lymphoma (say: lim-FOH-mah) is cancer of ...

  10. Development of a Web-Enabled Informatics Platform for Manipulation of Gene Expression Data

    National Research Council Canada - National Science Library

    Peel, Sheila A; Kopydlowski, Karen; Carel, Roland

    2004-01-01

    .... The Array Repository Data Analysis System (ARDAS 1.0) at Walter Reed Army Institute of Research is a web-enabled bioinformatic platform consisting of a Laboratory Information Management System (LIMS...

  11. A benchmarking study on information management systems for ...

    African Journals Online (AJOL)

    2003-01-01

    Jan 1, 2003 ... laboratories for safety and environmental issues, manpower administration, manpower training and development, and quality management. None of the laboratories have integrated these elements of management with the LIMS. The Integrated and Sustainable Laboratory. Management System (ISLMS).

  12. Positive solutions for a nonlinear periodic boundary-value problem with a parameter

    Directory of Open Access Journals (Sweden)

    Jingliang Qiu

    2012-08-01

    Full Text Available Using topological degree theory with a partially ordered structure of space, sufficient conditions for the existence and multiplicity of positive solutions for a second-order nonlinear periodic boundary-value problem are established. Inspired by ideas in Guo and Lakshmikantham [6], we study the dependence of positive periodic solutions as a parameter approaches infinity, $$ lim_{lambdao +infty}|x_{lambda}|=+infty,quadhbox{or}quad lim_{lambdao+infty}|x_{lambda}|=0. $$

  13. Evaluation of the Navys Sea/Shore Flow Policy

    Science.gov (United States)

    2016-06-01

    pregnancy , LimDu, etc.) rates by length of service (LOS). 3 Friction is caused by inefficiency in the...personnel management system due to four key factors: sailors not distributable due to limited duty (LimDu) or pregnancy ; distribution inefficiencies...shore and sea tour length determinations by the implementation of the exhaustive search in order to reduce the search space . This restriction

  14. Asymmetric k-Center with Minimum Coverage

    DEFF Research Database (Denmark)

    Gørtz, Inge Li

    2008-01-01

    In this paper we give approximation algorithms and inapproximability results for various asymmetric k-center with minimum coverage problems. In the k-center with minimum coverage problem, each center is required to serve a minimum number of clients. These problems have been studied by Lim et al. [A....... Lim, B. Rodrigues, F. Wang, Z. Xu, k-center problems with minimum coverage, Theoret. Comput. Sci. 332 (1–3) (2005) 1–17] in the symmetric setting....

  15. Region 7 Laboratory Information Management System

    Science.gov (United States)

    This is metadata documentation for the Region 7 Laboratory Information Management System (R7LIMS) which maintains records for the Regional Laboratory. Any Laboratory analytical work performed is stored in this system which replaces LIMS-Lite, and before that LAST. The EPA and its contractors may use this database. The Office of Policy & Management (PLMG) Division at EPA Region 7 is the primary managing entity; contractors can access this database but it is not accessible to the public.

  16. Rank one perturbations in a Pontryagin space with one negative square

    NARCIS (Netherlands)

    Derkach, [No Value; Hassi, Seppo; de Snoo, H

    2002-01-01

    Let N-1 denote the class of generalized Nevanfinna functions with one negative square and let N-1,N-0 be the subclass of functions Q(z) is an element of N, with the additional properties lim(y-->infinity) Q(i y)/y=0 and lim sup(y-->infinity) y\\Im Q(i y)\\ <&INFIN;. These classes form an analytic

  17. Effects of day-time exposure to different light intensities on light-induced melatonin suppression at night

    OpenAIRE

    Kozaki, Tomoaki; Kubokawa, Ayaka; Taketomi, Ryunosuke; Hatae, Keisuke

    2015-01-01

    Background Bright nocturnal light has been known to suppress melatonin secretion. However, bright light exposure during the day-time might reduce light-induced melatonin suppression (LIMS) at night. The effective proportion of day-time light to night-time light is unclear; however, only a few studies on accurately controlling both day- and night-time conditions have been conducted. This study aims to evaluate the effect of different day-time light intensities on LIMS. Methods Twelve male subj...

  18. Simulation of transient viscoelastic flow with second order time integration

    DEFF Research Database (Denmark)

    Rasmussen, Henrik Koblitz; Hassager, Ole

    1995-01-01

    The Lagrangian Integral Method (LIM) for the simulation of time-dependent flow of viscoelastic fluids is extended to second order accuracy in the time integration. The method is tested on the established sphere in a cylinder benchmark problem.......The Lagrangian Integral Method (LIM) for the simulation of time-dependent flow of viscoelastic fluids is extended to second order accuracy in the time integration. The method is tested on the established sphere in a cylinder benchmark problem....

  19. Splicing transitions of the anchoring protein ENH during striated muscle development.

    Science.gov (United States)

    Ito, Jumpei; Hashimoto, Taiki; Nakamura, Sho; Aita, Yusuke; Yamazaki, Tomoko; Schlegel, Werner; Takimoto, Koichi; Maturana, Andrés D

    2012-05-04

    The ENH (PDLIM5) protein acts as a scaffold to tether various functional proteins at subcellular sites via PDZ and three LIM domains. Splicing of the ENH primary transcript generates various products with different repertories of protein interaction modules. Three LIM-containing ENH predominates in neonatal cardiac tissue, whereas LIM-less ENHs are abundant in adult hearts, as well as skeletal muscles. Here we examine the timing of splicing transitions of ENH gene products during postnatal heart development and C2C12 myoblast differentiation. Real-time PCR analysis shows that LIM-containing ENH1 mRNA is gradually decreased during postnatal heart development, whereas transcripts with the short exon 5 appear in the late postnatal period and continues to increase until at least one month after birth. The splicing transition from LIM-containing ENH1 to LIM-less ENHs is also observed during the early period of C2C12 differentiation. This transition correlates with the emergence of ENH transcripts with the short exon 5, as well as the expression of myogenin mRNA. In contrast, the shift from the short exon 5 to the exon 7 occurs in the late differentiation period. The timing of this late event corresponds to the appearance of mRNA for the skeletal myosin heavy chain MYH4. Thus, coordinated and stepwise splicing transitions result in the production of specific ENH transcripts in mature striated muscles. Copyright © 2012 Elsevier Inc. All rights reserved.

  20. Development of an open source laboratory information management system for 2-D gel electrophoresis-based proteomics workflow

    Directory of Open Access Journals (Sweden)

    Toda Tosifusa

    2006-10-01

    Full Text Available Abstract Background In the post-genome era, most research scientists working in the field of proteomics are confronted with difficulties in management of large volumes of data, which they are required to keep in formats suitable for subsequent data mining. Therefore, a well-developed open source laboratory information management system (LIMS should be available for their proteomics research studies. Results We developed an open source LIMS appropriately customized for 2-D gel electrophoresis-based proteomics workflow. The main features of its design are compactness, flexibility and connectivity to public databases. It supports the handling of data imported from mass spectrometry software and 2-D gel image analysis software. The LIMS is equipped with the same input interface for 2-D gel information as a clickable map on public 2DPAGE databases. The LIMS allows researchers to follow their own experimental procedures by reviewing the illustrations of 2-D gel maps and well layouts on the digestion plates and MS sample plates. Conclusion Our new open source LIMS is now available as a basic model for proteome informatics, and is accessible for further improvement. We hope that many research scientists working in the field of proteomics will evaluate our LIMS and suggest ways in which it can be improved.